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<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBB0</accession>
    <name>A0A131MBB0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GlycosylPhosphatidylinositol Anchor Attachment 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">gpaa-1</name>
        <name evidence="5" type="synonym">hpo-3</name>
        <name evidence="3" type="ORF">CELE_F33D11.9</name>
        <name evidence="5" type="ORF">F33D11.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CZR14439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309526.1">
        <property type="nucleotide sequence ID" value="NM_001322680.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBB0"/>
    <dbReference type="GeneID" id="172256"/>
    <dbReference type="AGR" id="WB:WBGene00018006"/>
    <dbReference type="CTD" id="172256"/>
    <dbReference type="WormBase" id="F33D11.9f">
        <property type="protein sequence ID" value="CE09899"/>
        <property type="gene ID" value="WBGene00018006"/>
        <property type="gene designation" value="gpaa-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018006">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBB0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CZR14439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F33D11.9f"/>
        </source>
    </evidence>
    <sequence length="229" mass="25951" checksum="AEB21EA3BC05484D" modified="2016-05-11" version="1">MYIIPLTILVSPLVISAYFEWTKIQEFQFPVVHLAFHVLGFFYYIATTYVFQTIGTTFVLQWMQWPFVGIDGCDGQFTPSWSLINSFLIFFMIPLGPYVFLKTRSIFRSSVLAILNPISVLAFVAINIPGMFGQLFPTISQDSWLAAAQSIALTAIREDVEFKVNHFFLLCCFGYPIWNMLFACSMRYGPEPQGSLGIFGNGSDDDDGDDDDGPQKTNRGHSTKKNKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBB1</accession>
    <name>A0A131MBB1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Histone acetyltransferase</fullName>
            <ecNumber evidence="2 6">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">mys-2</name>
        <name evidence="9" type="ORF">CELE_K03D10.3</name>
        <name evidence="11" type="ORF">K03D10.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 6"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CZR14446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309533.1">
        <property type="nucleotide sequence ID" value="NM_001322692.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBB1"/>
    <dbReference type="SMR" id="A0A131MBB1"/>
    <dbReference type="GeneID" id="173281"/>
    <dbReference type="AGR" id="WB:WBGene00010537"/>
    <dbReference type="CTD" id="173281"/>
    <dbReference type="WormBase" id="K03D10.3c">
        <property type="protein sequence ID" value="CE51290"/>
        <property type="gene ID" value="WBGene00010537"/>
        <property type="gene designation" value="mys-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010537">
        <property type="expression patterns" value="Expressed in embryo and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBB1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000932">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF82">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CZR14446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="K03D10.3c"/>
        </source>
    </evidence>
    <sequence length="163" mass="19088" checksum="9A42903E41FD4669" modified="2016-05-11" version="1">MPEKPLSDLGKVSYRSYWWWRLMKLFHIHQGHTVTATFLSNESGIAVDDIVSTLITMRMCRQYKEPEFIPGEWYVRIHRKIVDHCVMCGYGKPPRLLLDRTKVRWAPAQTRPEFERQQQRTAAAMTSRRASKSQNVTPLVTPLATPPIEQKPVFQKTPTPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBB2</accession>
    <name>A0A131MBB2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Very long-chain fatty acid transport protein</fullName>
            <ecNumber evidence="14">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">acs-22</name>
        <name evidence="25" type="ORF">CELE_D1009.1</name>
        <name evidence="27" type="ORF">D1009.1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CZR14609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380195.1">
        <property type="nucleotide sequence ID" value="NM_001392815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBB2"/>
    <dbReference type="SMR" id="A0A131MBB2"/>
    <dbReference type="GeneID" id="181138"/>
    <dbReference type="AGR" id="WB:WBGene00017012"/>
    <dbReference type="CTD" id="181138"/>
    <dbReference type="WormBase" id="D1009.1c">
        <property type="protein sequence ID" value="CE51329"/>
        <property type="gene ID" value="WBGene00017012"/>
        <property type="gene designation" value="acs-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017012">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBB2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
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    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="5 25" id="KW-0436">Ligase</keyword>
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    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="28" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="23">
        <location>
            <begin position="85"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="24">
        <location>
            <begin position="524"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CZR14609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="D1009.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="28">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBB2"/>
        </source>
    </evidence>
    <sequence length="652" mass="73099" checksum="1E4DCE1E0E9A0444" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBB4</accession>
    <name>A0A131MBB4_CAEEL</name>
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        <submittedName>
            <fullName evidence="8">Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein</fullName>
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        <name evidence="8 10" type="primary">coh-1</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rad21 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CZR14630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CE51389"/>
        <property type="gene ID" value="WBGene00000591"/>
        <property type="gene designation" value="coh-1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
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        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="7">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CZR14630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="K08A8.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBB4"/>
        </source>
    </evidence>
    <sequence length="164" mass="18969" checksum="E0F7D3713C7BE01B" modified="2016-05-11" version="1">MDMHVQDDSSYVDDFDEVPPLDFDQLDMMDMPQSMDDINMVDDDVPQRNPLSPFAPMVEDEEMSPSEKRKKRDEEKEEPETDEDNRWSKRTHALLQNIATKLENQNGQVELDEMLKKGTSRKVAAAKFYSLLCLKKNQCIDIEQKEPYGDIMIKAGPNININTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBC0</accession>
    <name>A0A131MBC0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sideroflexin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">sfxn-5</name>
        <name evidence="12" type="ORF">C41C4.10</name>
        <name evidence="10" type="ORF">CELE_C41C4.10</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309542.1">
        <property type="nucleotide sequence ID" value="NM_001322747.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBC0"/>
    <dbReference type="GeneID" id="174303"/>
    <dbReference type="AGR" id="WB:WBGene00044049"/>
    <dbReference type="CTD" id="174303"/>
    <dbReference type="WormBase" id="C41C4.10b">
        <property type="protein sequence ID" value="CE51493"/>
        <property type="gene ID" value="WBGene00044049"/>
        <property type="gene designation" value="sfxn-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044049">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBC0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="203"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CZR14457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C41C4.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBC0"/>
        </source>
    </evidence>
    <sequence length="233" mass="25844" checksum="3121F5E0F9B65496" modified="2016-05-11" version="1">MSGFVPFGWITVTGMLLPNPSWPTLLFWQWMNQSHNACVNYANRNATQPQPLSKYIGAYGAAVTAACSISGGLTYFIKKASSLPPTTRIIIQRFVPLPATSLASSLNVICMRWNELETGIQVYEKDTGKVVGVSKVAAKQAVTDTTMVRAFLPVPLLLMPPCIMPYLERFKWVTKTQVRHIFVNAIVCTLSFAVSLPVALALFPQESAISREQLEPELQQKTKNSLLYYNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBG0</accession>
    <name>A0A131MBG0_CAEEL</name>
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        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">brf-1</name>
        <name evidence="14" type="ORF">CELE_F45E12.2</name>
        <name evidence="16" type="ORF">F45E12.2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
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    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001309558.1">
        <property type="nucleotide sequence ID" value="NM_001322740.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBG0"/>
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    <dbReference type="AGR" id="WB:WBGene00000271"/>
    <dbReference type="CTD" id="174199"/>
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        <property type="protein sequence ID" value="CE51360"/>
        <property type="gene ID" value="WBGene00000271"/>
        <property type="gene designation" value="brf-1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Single helix bin"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
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        <location>
            <begin position="452"/>
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        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
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        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CZR14474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="F45E12.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBG0"/>
        </source>
    </evidence>
    <sequence length="741" mass="82056" checksum="67DE4B6AD4913BFE" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBG4</accession>
    <name>A0A131MBG4_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Elongator complex protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_W09B6.4</name>
        <name evidence="2 4" type="ORF">W09B6.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="W09B6.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBG4"/>
        </source>
    </evidence>
    <sequence length="256" mass="28701" checksum="0E8CF9BFF49EBD37" modified="2016-05-11" version="1">MSTFYDAPKSSVAVFQFPDTDPLEALKILRSALQTDKKSIICHSAFATWYKEFHVEWNEDFVEFSDESYKNVEKIDREVVIFADFDVFSMIFGISKTLNLIKTLKTKKRIFIVTSLDFPATPHLEHLTNSTFKVKKSANPEIFECQTTVFDKKGNLTIMDQIITMPPSGTKPTFKTVKKVENSAENSISAGISGISLGSESGKAAMDLPFFVSRQEDGVALRDAATKKIRVGGQIVYEPDQEDDLDDSDPDDDLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBH1</accession>
    <name>A0A131MBH1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
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    <gene>
        <name evidence="8 10" type="primary">best-10</name>
        <name evidence="10" type="ORF">C49A1.2</name>
        <name evidence="8" type="ORF">CELE_C49A1.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CZR14430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309517.1">
        <property type="nucleotide sequence ID" value="NM_001322694.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBH1"/>
    <dbReference type="GeneID" id="183586"/>
    <dbReference type="AGR" id="WB:WBGene00008185"/>
    <dbReference type="CTD" id="183586"/>
    <dbReference type="WormBase" id="C49A1.2b">
        <property type="protein sequence ID" value="CE51268"/>
        <property type="gene ID" value="WBGene00008185"/>
        <property type="gene designation" value="best-10"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008185">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBH1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF58">
        <property type="entry name" value="BESTROPHIN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CZR14430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="C49A1.2b"/>
        </source>
    </evidence>
    <sequence length="130" mass="14790" checksum="638B830BCC13A6CA" modified="2016-05-11" version="1">MKVAEILLNPMGEDDDDFELNYVIDKNFYIGMTIVDSKDIELTENDEIPDKIGEDCLPFYRKDCEEDAIKNRALVGSTKNTMPNQGVMDKVEENSIQVVDDNWRDYNENHSDTSSILEGSQEDFADDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBH5</accession>
    <name>A0A131MBH5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">trpp-11</name>
        <name evidence="4" type="ORF">B0412.3</name>
        <name evidence="2" type="ORF">CELE_B0412.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CZR14503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_497264.2">
        <property type="nucleotide sequence ID" value="NM_064863.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBH5"/>
    <dbReference type="SMR" id="A0A131MBH5"/>
    <dbReference type="GeneID" id="175236"/>
    <dbReference type="AGR" id="WB:WBGene00015173"/>
    <dbReference type="CTD" id="175236"/>
    <dbReference type="WormBase" id="B0412.3b">
        <property type="protein sequence ID" value="CE51342"/>
        <property type="gene ID" value="WBGene00015173"/>
        <property type="gene designation" value="trpp-11"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015173">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBH5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="1">
        <location>
            <begin position="2"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="B0412.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBH5"/>
        </source>
    </evidence>
    <sequence length="819" mass="90297" checksum="CEC53384B6FF4A63" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBH6</accession>
    <name>A0A131MBH6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">wht-3</name>
        <name evidence="11" type="ORF">C16C10.12</name>
        <name evidence="9" type="ORF">CELE_C16C10.12</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CZR14510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309590.1">
        <property type="nucleotide sequence ID" value="NM_001322781.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBH6"/>
    <dbReference type="SMR" id="A0A131MBH6"/>
    <dbReference type="GeneID" id="175528"/>
    <dbReference type="AGR" id="WB:WBGene00007631"/>
    <dbReference type="CTD" id="175528"/>
    <dbReference type="WormBase" id="C16C10.12c">
        <property type="protein sequence ID" value="CE51548"/>
        <property type="gene ID" value="WBGene00007631"/>
        <property type="gene designation" value="wht-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007631">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBH6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF31">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE WHT-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="2"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CZR14510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C16C10.12c"/>
        </source>
    </evidence>
    <sequence length="542" mass="61359" checksum="1D88E56D4594FE84" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBI1</accession>
    <name>A0A131MBI1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING finger protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rnf-5</name>
        <name evidence="5" type="ORF">C16C10.7</name>
        <name evidence="3" type="ORF">CELE_C16C10.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CZR14513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309593.1">
        <property type="nucleotide sequence ID" value="NM_001322784.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBI1"/>
    <dbReference type="GeneID" id="175532"/>
    <dbReference type="AGR" id="WB:WBGene00004381"/>
    <dbReference type="CTD" id="175532"/>
    <dbReference type="WormBase" id="C16C10.7c">
        <property type="protein sequence ID" value="CE51483"/>
        <property type="gene ID" value="WBGene00004381"/>
        <property type="gene designation" value="rnf-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004381">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBI1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CZR14513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C16C10.7c"/>
        </source>
    </evidence>
    <sequence length="117" mass="12266" checksum="0A406BE244C3F033" modified="2016-05-11" version="1">MMGGGGPNVHFSFGIGTVNGLFPLMFMLPFIQGIFPLSFVASFFGNGNQGAAAAGGGNGGGNDGNDGTHAHTHGHTHGPRGHGESAAPGSRMAQEEEYLSNIFKYIGFFMLFWLLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBI3</accession>
    <name>A0A131MBI3_CAEEL</name>
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        <submittedName>
            <fullName evidence="5">Ku_PK_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">cku-80</name>
        <name evidence="5" type="ORF">CELE_R07E5.8</name>
        <name evidence="7" type="ORF">R07E5.8</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CZR14520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309599.1">
        <property type="nucleotide sequence ID" value="NM_001322520.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBI3"/>
    <dbReference type="GeneID" id="175578"/>
    <dbReference type="AGR" id="WB:WBGene00000520"/>
    <dbReference type="CTD" id="175578"/>
    <dbReference type="WormBase" id="R07E5.8b">
        <property type="protein sequence ID" value="CE51551"/>
        <property type="gene ID" value="WBGene00000520"/>
        <property type="gene designation" value="cku-80"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000520">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBI3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000008">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.240:FF:000005">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ku C-terminal" evidence="4">
        <location>
            <begin position="257"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CZR14520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="R07E5.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBI3"/>
        </source>
    </evidence>
    <sequence length="332" mass="38174" checksum="5F2FAECDC50E6F62" modified="2016-05-11" version="1">MLSLRVAAICRYTFHAKSHVQLIALLPHQDEETGVFYLRSVKLPFSDDMRTLKFPKFSFDEEDEDLNKPTVAQLSAVDDLIDCMQLQEDEISSLVEGGMSDPKLQMQCHFLKSLVLHPNDTFENHSNRTNQILDQIMAPKRRVEAEHPEIFQKLGREFNLQPIQKTKRERVTVEPEDLQTMISEWTEKKQNMTQPDEVDDGASQKKKKKPNAKKLTRKEEVQMDIMEDGGASRVCSKILEMISNTCKFQPNGAVTEFFTLLVNELNVIRSVFVENSKCDEFNELLKKLKDEEDFEPFAEVLSEEKSCNPIDSSEVSMSEVSVANAAEFWEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBI5</accession>
    <name>A0A131MBI5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GlycosylPhosphatidylinositol Anchor Attachment 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">gpaa-1</name>
        <name evidence="5" type="synonym">hpo-3</name>
        <name evidence="3" type="ORF">CELE_F33D11.9</name>
        <name evidence="5" type="ORF">F33D11.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CZR14440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309527.1">
        <property type="nucleotide sequence ID" value="NM_001322682.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBI5"/>
    <dbReference type="SMR" id="A0A131MBI5"/>
    <dbReference type="GeneID" id="172256"/>
    <dbReference type="AGR" id="WB:WBGene00018006"/>
    <dbReference type="CTD" id="172256"/>
    <dbReference type="WormBase" id="F33D11.9g">
        <property type="protein sequence ID" value="CE51400"/>
        <property type="gene ID" value="WBGene00018006"/>
        <property type="gene designation" value="gpaa-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018006">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBI5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CZR14440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F33D11.9g"/>
        </source>
    </evidence>
    <sequence length="220" mass="24495" checksum="C72458B3680EBC2F" modified="2016-05-11" version="1">MQWPFVGIDGCDGQFTPSWSLINSFLIFFMIPLGPYVFLKEPVRCVPSMRIVCLLETSLVLYGICLTNFGLAILCTAFVVPIVFLMTYESSDRTRSIFRSSVLAILNPISVLAFVAINIPGMFGQLFPTISQDSWLAAAQSIALTAIREDVEFKVNHFFLLCCFGYPIWNMLFACSMRYGPEPQGSLGIFGNGSDDDDGDDDDGPQKTNRGHSTKKNKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBJ3</accession>
    <name>A0A131MBJ3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle collagen 99</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">col-99</name>
        <name evidence="4" type="ORF">CELE_F29C4.8</name>
        <name evidence="6" type="ORF">F29C4.8</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CZR14530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309609.1">
        <property type="nucleotide sequence ID" value="NM_001322770.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBJ3"/>
    <dbReference type="SMR" id="A0A131MBJ3"/>
    <dbReference type="GeneID" id="185112"/>
    <dbReference type="AGR" id="WB:WBGene00000674"/>
    <dbReference type="CTD" id="185112"/>
    <dbReference type="WormBase" id="F29C4.8n">
        <property type="protein sequence ID" value="CE51428"/>
        <property type="gene ID" value="WBGene00000674"/>
        <property type="gene designation" value="col-99"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8964326at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000674">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBJ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VVC12363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5E4M2I1"/>
    <dbReference type="SMR" id="A0A5E4M2I1"/>
    <dbReference type="PaxDb" id="6239-K09E9.3"/>
    <dbReference type="AGR" id="WB:WBGene00010726"/>
    <dbReference type="WormBase" id="K09E9.3a">
        <property type="protein sequence ID" value="CE53675"/>
        <property type="gene ID" value="WBGene00010726"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5820204at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A5E4M2I1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VVC12363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K09E9.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A5E4M2I1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51235" checksum="2F6065F865C075AF" modified="2019-11-13" version="1">MKPAPNAGPSSSSGSNAPSSTEKKIIMVATEQRLYELACKARAKGMFVRIPPSHKRARAVAEEMAKFMAYERYTVVKPLADLTDVHQAIKDLSFVKTEKLNQRPGYSHIMTVLKEEFQNYSALAHQRGLDERGEIYQLLAHYPKLGLILQRITQRRPLRYGGVIDEKHACTHIKKTSIQVASFLNNKTRERVVNPVGIRCEVCEKEVEAAANEKLDVMHQRLEEEMNDFTVDASLQPHSFEKTFKMSKVNIDGIESQDYVKPIDTLRKIWNMDLAGIDNREMLFKKRIQQQKLTAMFNIYNDKEIGEELDGVVKEIETLANDIQEKDAETVTQLQVLKESFGGAWEKARKCLGTKSALSSDDRNIRRLQEKLEEAEKENAKLRSLLEKEKAKNRSDDGKHSSKYLKKDKGRDKDEEDERRERKHKVKDRDEASSSSSSHSFSAKRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4Q9E2</accession>
    <name>A0A8S4Q9E2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">ssp-28</name>
        <name evidence="3" type="ORF">CELE_R74.10</name>
        <name evidence="5" type="ORF">R74.10</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAH2175441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001391132.1">
        <property type="nucleotide sequence ID" value="NM_001404276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4Q9E2"/>
    <dbReference type="SMR" id="A0A8S4Q9E2"/>
    <dbReference type="GeneID" id="13189130"/>
    <dbReference type="AGR" id="WB:WBGene00206525"/>
    <dbReference type="CTD" id="13189130"/>
    <dbReference type="WormBase" id="R74.10b">
        <property type="protein sequence ID" value="CE54398"/>
        <property type="gene ID" value="WBGene00206525"/>
        <property type="gene designation" value="ssp-28"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5842335at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saposin B-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH2175441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="R74.10b"/>
        </source>
    </evidence>
    <sequence length="71" mass="8068" checksum="6D15A5D26EAEB3E7" modified="2022-10-12" version="1">MLCTVVSESLEREMTPTATVNSMFKKCDKMGLMEPVCVQFVSENVKEMFQRVRQGIPSTSVCQALRFCDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4Q9J2</accession>
    <name>A0A8S4Q9J2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">wht-7</name>
        <name evidence="11" type="ORF">CELE_Y42G9A.6</name>
        <name evidence="13" type="ORF">Y42G9A.6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAH2176190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001391161.1">
        <property type="nucleotide sequence ID" value="NM_001404161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4Q9J2"/>
    <dbReference type="SMR" id="A0A8S4Q9J2"/>
    <dbReference type="GeneID" id="175864"/>
    <dbReference type="AGR" id="WB:WBGene00021535"/>
    <dbReference type="CTD" id="175864"/>
    <dbReference type="WormBase" id="Y42G9A.6d">
        <property type="protein sequence ID" value="CE54425"/>
        <property type="gene ID" value="WBGene00021535"/>
        <property type="gene designation" value="wht-7"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004155">
        <property type="entry name" value="WHiTe (Drosophila) related ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="54"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH2176190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="Y42G9A.6d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4Q9J2"/>
        </source>
    </evidence>
    <sequence length="653" mass="73738" checksum="3DA1420A86B7D584" modified="2022-10-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4Q9K5</accession>
    <name>A0A8S4Q9K5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Suppressor of PAr-Two defect</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">spat-2</name>
        <name evidence="2" type="ORF">CELE_Y48A6B.13</name>
        <name evidence="4" type="ORF">Y48A6B.13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAH2176282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001391171.1">
        <property type="nucleotide sequence ID" value="NM_001404167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4Q9K5"/>
    <dbReference type="GeneID" id="3564779"/>
    <dbReference type="AGR" id="WB:WBGene00012973"/>
    <dbReference type="CTD" id="3564779"/>
    <dbReference type="WormBase" id="Y48A6B.13o">
        <property type="protein sequence ID" value="CE54422"/>
        <property type="gene ID" value="WBGene00012973"/>
        <property type="gene designation" value="spat-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5845256at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH2176282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y48A6B.13o"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4Q9K5"/>
        </source>
    </evidence>
    <sequence length="944" mass="103897" checksum="852BE903A6527691" modified="2022-10-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-01-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>D1MN82</accession>
    <name>D1MN82_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_D2023.1</name>
        <name evidence="7 9" type="ORF">D2023.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode receptor-like protein sre family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBI63212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D1MN82"/>
    <dbReference type="SMR" id="D1MN82"/>
    <dbReference type="AGR" id="WB:WBGene00014300"/>
    <dbReference type="WormBase" id="D2023.1g">
        <property type="protein sequence ID" value="CE44295"/>
        <property type="gene ID" value="WBGene00014300"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154803_0_0_1"/>
    <dbReference type="OrthoDB" id="5811630at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014300">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D1MN82">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004151">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sre"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03125">
        <property type="entry name" value="Sre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBI63212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="D2023.1g"/>
        </source>
    </evidence>
    <sequence length="137" mass="15900" checksum="9DB45FE24BB048CB" modified="2010-01-19" version="1">MEAVRENIRTSRLLIQIFFIFAFFVGTSTFFLLKFSASLTDPSQKWTTIKNGFMYDILICIGTTCTTTVFLQFLIPDDTLKKWRLKFHLSCQQRSVTPEGKRLRFRSIHGIDVEVGNGTAEEEARVYFTQLSQAWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-07-13" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D5SH01</accession>
    <name>D5SH01_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homolog of Odr-2 (Two)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">hot-2</name>
        <name evidence="2" type="ORF">CELE_Y39B6A.48</name>
        <name evidence="4" type="ORF">Y39B6A.48</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBL87062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256848.1">
        <property type="nucleotide sequence ID" value="NM_001269919.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D5SH01"/>
    <dbReference type="GeneID" id="180261"/>
    <dbReference type="AGR" id="WB:WBGene00001987"/>
    <dbReference type="CTD" id="180261"/>
    <dbReference type="WormBase" id="Y39B6A.48b">
        <property type="protein sequence ID" value="CE45024"/>
        <property type="gene ID" value="WBGene00001987"/>
        <property type="gene designation" value="hot-2"/>
    </dbReference>
    <dbReference type="OMA" id="PRRFECF"/>
    <dbReference type="OrthoDB" id="5917524at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001987">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D5SH01">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722:SF4">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003075955" evidence="1">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL87062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y39B6A.48b"/>
        </source>
    </evidence>
    <sequence length="199" mass="22471" checksum="3FFAE4A60967F0CF" modified="2010-07-13" version="1">MIIRLILILMTSSMTFSAINPATKLSNFDESFGRSSGAGAPIPRQVECYSCMSLSYQTSWKYLQTTYIYPKVFTDRCRDPNSERGMPTVMCGSVCVSLMEPDVEAGVFIGFKHIRGCLDRVLRHGFNQSALRTHRFHQNNHCRTLSRSALFNPARQTDPPALGDVQLCSCYGDRCNSTIMTSSSIFIVFLLVFLHRLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6S3</accession>
    <name>E1B6S3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine-rich motor neuron 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">crim-1</name>
        <name evidence="7" type="synonym">crm-1</name>
        <name evidence="7" type="ORF">B0024.14</name>
        <name evidence="5" type="ORF">CELE_B0024.14</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6S3"/>
    <dbReference type="SMR" id="E1B6S3"/>
    <dbReference type="KEGG" id="cel:CELE_B0024.14"/>
    <dbReference type="AGR" id="WB:WBGene00007103"/>
    <dbReference type="CTD" id="179439"/>
    <dbReference type="WormBase" id="B0024.14f">
        <property type="protein sequence ID" value="CE45311"/>
        <property type="gene ID" value="WBGene00007103"/>
        <property type="gene designation" value="crim-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306585_0_0_1"/>
    <dbReference type="OrthoDB" id="5976811at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007103">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6S3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052624">
        <property type="entry name" value="CRIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46439">
        <property type="entry name" value="CYSTEINE-RICH MOTOR NEURON 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46439:SF1">
        <property type="entry name" value="CYSTEINE-RICH MOTOR NEURON 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23334">
        <property type="entry name" value="VWC2L_2nd"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51252">
        <property type="entry name" value="ANTISTASIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
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</entry>
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        </source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA98246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C29A12.4e"/>
        </source>
    </evidence>
    <sequence length="137" mass="14768" checksum="5259386DED23E9AC" modified="2010-11-02" version="1">MGDTITTTMQAATVTDFPRTPLIMCSSLAVIIAIAAVVFFVFKCRQNPPNSEHYTMAMKSQSGYTAIAPELSPPMNHDRSNDSCTQPLLAKPHINGNGYEPLKGAVIANGNGATATMMRNGNGNGVAKKKDFKEWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6S9</accession>
    <name>E1B6S9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_D1054.18</name>
        <name evidence="1 3" type="ORF">D1054.18</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256258.1">
        <property type="nucleotide sequence ID" value="NM_001269329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6S9"/>
    <dbReference type="GeneID" id="7040149"/>
    <dbReference type="AGR" id="WB:WBGene00077783"/>
    <dbReference type="CTD" id="7040149"/>
    <dbReference type="WormBase" id="D1054.18b">
        <property type="protein sequence ID" value="CE42804"/>
        <property type="gene ID" value="WBGene00077783"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2887876_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00077783">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6S9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBW48352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="D1054.18b"/>
        </source>
    </evidence>
    <sequence length="58" mass="6929" checksum="F034C031A09CA63E" modified="2010-11-02" version="1">MHAAVITSYFTKPMIVDEEEKMEEKIQEPKKRVAIDQDKLVDENSMECFLEFLIEFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6T1</accession>
    <name>E1B6T1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">glb-24</name>
        <name evidence="6" type="ORF">CELE_R90.5</name>
        <name evidence="8" type="ORF">R90.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001269534.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6T1"/>
    <dbReference type="SMR" id="E1B6T1"/>
    <dbReference type="GeneID" id="179767"/>
    <dbReference type="AGR" id="WB:WBGene00011287"/>
    <dbReference type="CTD" id="179767"/>
    <dbReference type="WormBase" id="R90.5b">
        <property type="protein sequence ID" value="CE45382"/>
        <property type="gene ID" value="WBGene00011287"/>
        <property type="gene designation" value="glb-24"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_928236_0_0_1"/>
    <dbReference type="OrthoDB" id="5780832at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011287">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6T1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF16">
        <property type="entry name" value="GLOBIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="120"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBW48432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="R90.5b"/>
        </source>
    </evidence>
    <sequence length="300" mass="33685" checksum="39459F9527A022D7" modified="2010-11-02" version="1">MDHTMMPVISITRTRRCSVSSPLRFTRTFSEDSLDSLEKNGRKELRRQRIMENGGSVEKEKNSLNPLAHTTCPHLGQMGRSRTECPEAESLRLPLTSKRSAGDLSCPPSPTRRNLNEVIGLSPYQQKLLVQCWPNIYTTGASGPFANSLYSTLSSRNAKAKELLAKADGVAVFSKSDFDCSVMHCRVTVEILDTVIKNLDNDHARITQYLTEIGKQHRHLKAEGLSSAVWDDLGDTIMDCARRRCEAVRKHKELRRAWLAIIAYIMDNLKQGQSMTRSSSTYDLSYDSSKVPCTKKNSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6T2</accession>
    <name>E1B6T2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">glb-24</name>
        <name evidence="6" type="ORF">CELE_R90.5</name>
        <name evidence="8" type="ORF">R90.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256464.1">
        <property type="nucleotide sequence ID" value="NM_001269535.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6T2"/>
    <dbReference type="SMR" id="E1B6T2"/>
    <dbReference type="GeneID" id="179767"/>
    <dbReference type="AGR" id="WB:WBGene00011287"/>
    <dbReference type="CTD" id="179767"/>
    <dbReference type="WormBase" id="R90.5c">
        <property type="protein sequence ID" value="CE45305"/>
        <property type="gene ID" value="WBGene00011287"/>
        <property type="gene designation" value="glb-24"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_928236_0_0_1"/>
    <dbReference type="OrthoDB" id="5780832at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011287">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6T2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF16">
        <property type="entry name" value="GLOBIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="70"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBW48433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="R90.5c"/>
        </source>
    </evidence>
    <sequence length="250" mass="27764" checksum="3D734BE0602940CB" modified="2010-11-02" version="1">MENGGSVEKEKNSLNPLAHTTCPHLGQMGRSRTECPEAESLRLPLTSKRSAGDLSCPPSPTRRNLNEVIGLSPYQQKLLVQCWPNIYTTGASGPFANSLYSTLSSRNAKAKELLAKADGVAVFSKSDFDCSVMHCRVTVEILDTVIKNLDNDHARITQYLTEIGKQHRHLKAEGLSSAVWDDLGDTIMDCARRRCEAVRKHKELRRAWLAIIAYIMDNLKQGQSMTRSSSTYDLSYDSSKVPCTKKNSSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY84-2</accession>
    <name>CMTA1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Calmodulin-binding transcription activator homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">camt-1</name>
        <name evidence="3" type="ORF">T05C1.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
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        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF 142-GLY-LYS-143; 175-ARG-ARG-176; 189-VAL--LEU-192 AND 631-ARG--ALA-1185</scope>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>Neuronal calmodulin levels are controlled by CAMTA transcription factors.</title>
            <authorList>
                <person name="Vuong-Brender T.T."/>
                <person name="Flynn S."/>
                <person name="Vallis Y."/>
                <person name="de Bono M."/>
            </authorList>
            <dbReference type="PubMed" id="34499028"/>
            <dbReference type="DOI" id="10.7554/elife.68238"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF 142-GLY-LYS-143; 175-ARG-ARG-176; 189-VAL--LEU-192 AND 631-ARG--ALA-1185</scope>
    </reference>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Bristol N2</strain>
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    <reference evidence="1" key="2">
        <citation type="journal article" date="2007" name="Biochem. Biophys. Res. Commun." volume="358" first="545" last="552">
            <title>Differential expression pattern of UBX family genes in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Yamauchi S."/>
                <person name="Sasagawa Y."/>
                <person name="Ogura T."/>
                <person name="Yamanaka K."/>
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            <dbReference type="PubMed" id="17498661"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2007.04.163"/>
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        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2010" name="Genes Cells" volume="15" first="1201" last="1215">
            <title>Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis.</title>
            <authorList>
                <person name="Sasagawa Y."/>
                <person name="Yamanaka K."/>
                <person name="Saito-Sasagawa Y."/>
                <person name="Ogura T."/>
            </authorList>
            <dbReference type="PubMed" id="20977550"/>
            <dbReference type="DOI" id="10.1111/j.1365-2443.2010.01454.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN A COMPLEX WITH CDC-48.1; UFD-1 AND NPL-4.1</scope>
        <scope>INTERACTION WITH CDC-48.1 AND CDC-48.2</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10612" last="10612">
            <title>Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.</title>
            <authorList>
                <person name="Franz A."/>
                <person name="Pirson P.A."/>
                <person name="Pilger D."/>
                <person name="Halder S."/>
                <person name="Achuthankutty D."/>
                <person name="Kashkar H."/>
                <person name="Ramadan K."/>
                <person name="Hoppe T."/>
            </authorList>
            <dbReference type="PubMed" id="26842564"/>
            <dbReference type="DOI" id="10.1038/ncomms10612"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN A COMPLEX WITH CDC-48 AND CDT-1</scope>
        <scope>INTERACTION WITH CDC-48 AND CDT-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 582-PHE--LYS-584</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2017" name="Nat. Cell Biol." volume="19" first="468" last="479">
            <title>CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.</title>
            <authorList>
                <person name="Sonneville R."/>
                <person name="Moreno S.P."/>
                <person name="Knebel A."/>
                <person name="Johnson C."/>
                <person name="Hastie C.J."/>
                <person name="Gartner A."/>
                <person name="Gambus A."/>
                <person name="Labib K."/>
            </authorList>
            <dbReference type="PubMed" id="28368371"/>
            <dbReference type="DOI" id="10.1038/ncb3500"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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            <strain evidence="2">Bristol N2</strain>
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    <reference evidence="1" key="2">
        <citation type="journal article" date="2007" name="Biochem. Biophys. Res. Commun." volume="358" first="545" last="552">
            <title>Differential expression pattern of UBX family genes in Caenorhabditis elegans.</title>
            <authorList>
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                <person name="Sasagawa Y."/>
                <person name="Ogura T."/>
                <person name="Yamanaka K."/>
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            <dbReference type="PubMed" id="17498661"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2007.04.163"/>
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        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
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    <reference evidence="1" key="3">
        <citation type="journal article" date="2010" name="Genes Cells" volume="15" first="1201" last="1215">
            <title>Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis.</title>
            <authorList>
                <person name="Sasagawa Y."/>
                <person name="Yamanaka K."/>
                <person name="Saito-Sasagawa Y."/>
                <person name="Ogura T."/>
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            <dbReference type="PubMed" id="20977550"/>
            <dbReference type="DOI" id="10.1111/j.1365-2443.2010.01454.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN A COMPLEX WITH CDC-48.1; UFD-1 AND NPL-4.1</scope>
        <scope>INTERACTION WITH CDC-48.1 AND CDC-48.2</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10612" last="10612">
            <title>Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.</title>
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                <person name="Franz A."/>
                <person name="Pirson P.A."/>
                <person name="Pilger D."/>
                <person name="Halder S."/>
                <person name="Achuthankutty D."/>
                <person name="Kashkar H."/>
                <person name="Ramadan K."/>
                <person name="Hoppe T."/>
            </authorList>
            <dbReference type="PubMed" id="26842564"/>
            <dbReference type="DOI" id="10.1038/ncomms10612"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN A COMPLEX WITH CDC-48 AND CDT-1</scope>
        <scope>INTERACTION WITH CDC-48 AND CDT-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 582-PHE--LYS-584</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2017" name="Nat. Cell Biol." volume="19" first="468" last="479">
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                <person name="Moreno S.P."/>
                <person name="Knebel A."/>
                <person name="Johnson C."/>
                <person name="Hastie C.J."/>
                <person name="Gartner A."/>
                <person name="Gambus A."/>
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            <dbReference type="PubMed" id="28368371"/>
            <dbReference type="DOI" id="10.1038/ncb3500"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F48A11.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F48A11.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F48A11.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F48A11.5d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F48A11.5e"/>
        </source>
    </evidence>
    <sequence length="514" mass="58427" checksum="73A46DD2217F6D16" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-05-23" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>H2L056-4</accession>
    <name>UBXN3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of UBX domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ubxn-3</name>
        <name evidence="3" type="ORF">F48A11.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2007" name="Biochem. Biophys. Res. Commun." volume="358" first="545" last="552">
            <title>Differential expression pattern of UBX family genes in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Yamauchi S."/>
                <person name="Sasagawa Y."/>
                <person name="Ogura T."/>
                <person name="Yamanaka K."/>
            </authorList>
            <dbReference type="PubMed" id="17498661"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2007.04.163"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2010" name="Genes Cells" volume="15" first="1201" last="1215">
            <title>Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis.</title>
            <authorList>
                <person name="Sasagawa Y."/>
                <person name="Yamanaka K."/>
                <person name="Saito-Sasagawa Y."/>
                <person name="Ogura T."/>
            </authorList>
            <dbReference type="PubMed" id="20977550"/>
            <dbReference type="DOI" id="10.1111/j.1365-2443.2010.01454.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN A COMPLEX WITH CDC-48.1; UFD-1 AND NPL-4.1</scope>
        <scope>INTERACTION WITH CDC-48.1 AND CDC-48.2</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10612" last="10612">
            <title>Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.</title>
            <authorList>
                <person name="Franz A."/>
                <person name="Pirson P.A."/>
                <person name="Pilger D."/>
                <person name="Halder S."/>
                <person name="Achuthankutty D."/>
                <person name="Kashkar H."/>
                <person name="Ramadan K."/>
                <person name="Hoppe T."/>
            </authorList>
            <dbReference type="PubMed" id="26842564"/>
            <dbReference type="DOI" id="10.1038/ncomms10612"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN A COMPLEX WITH CDC-48 AND CDT-1</scope>
        <scope>INTERACTION WITH CDC-48 AND CDT-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 582-PHE--LYS-584</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2017" name="Nat. Cell Biol." volume="19" first="468" last="479">
            <title>CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.</title>
            <authorList>
                <person name="Sonneville R."/>
                <person name="Moreno S.P."/>
                <person name="Knebel A."/>
                <person name="Johnson C."/>
                <person name="Hastie C.J."/>
                <person name="Gartner A."/>
                <person name="Gambus A."/>
                <person name="Labib K."/>
            </authorList>
            <dbReference type="PubMed" id="28368371"/>
            <dbReference type="DOI" id="10.1038/ncb3500"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2L056-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_059594"/>
        </isoform>
        <isoform>
            <id>H2L056-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2L056-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_059593"/>
        </isoform>
        <isoform>
            <id>H2L056-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_059592"/>
        </isoform>
        <isoform>
            <id>H2L056-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_059593 VSP_059594"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001300548.1">
        <property type="nucleotide sequence ID" value="NM_001313619.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F48A11.5d">
        <property type="protein sequence ID" value="CE50868"/>
        <property type="gene ID" value="WBGene00018586"/>
        <property type="gene designation" value="ubxn-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F48A11.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F48A11.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F48A11.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F48A11.5d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F48A11.5e"/>
        </source>
    </evidence>
    <sequence length="234" mass="27601" checksum="DB5C80D3F0741C07" modified="2012-03-21" version="1">MLFLEYLQAANMGDVRTIIQRLAMSKIESFPLMAIVVKERNSYRLVDYCRGTDTSDQVMEKLLSGVSEYSDIRMNEQSERREREEREAIRNQQEAEYKASLAADKARMEAKQQEIEEQRLEEERKLREEEEECVRRQTVASTVPEEPPASAPLAEIINVKFRLPEGGQDMRRFRRLESIQTLINYLSSKGYSPDKFKYFNSDFPKKEITRHFDLSHNFADTKWPAREQIFVEEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-05-23" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>H2L056-5</accession>
    <name>UBXN3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform e of UBX domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ubxn-3</name>
        <name evidence="3" type="ORF">F48A11.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2007" name="Biochem. Biophys. Res. Commun." volume="358" first="545" last="552">
            <title>Differential expression pattern of UBX family genes in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Yamauchi S."/>
                <person name="Sasagawa Y."/>
                <person name="Ogura T."/>
                <person name="Yamanaka K."/>
            </authorList>
            <dbReference type="PubMed" id="17498661"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2007.04.163"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2010" name="Genes Cells" volume="15" first="1201" last="1215">
            <title>Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis.</title>
            <authorList>
                <person name="Sasagawa Y."/>
                <person name="Yamanaka K."/>
                <person name="Saito-Sasagawa Y."/>
                <person name="Ogura T."/>
            </authorList>
            <dbReference type="PubMed" id="20977550"/>
            <dbReference type="DOI" id="10.1111/j.1365-2443.2010.01454.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN A COMPLEX WITH CDC-48.1; UFD-1 AND NPL-4.1</scope>
        <scope>INTERACTION WITH CDC-48.1 AND CDC-48.2</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10612" last="10612">
            <title>Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.</title>
            <authorList>
                <person name="Franz A."/>
                <person name="Pirson P.A."/>
                <person name="Pilger D."/>
                <person name="Halder S."/>
                <person name="Achuthankutty D."/>
                <person name="Kashkar H."/>
                <person name="Ramadan K."/>
                <person name="Hoppe T."/>
            </authorList>
            <dbReference type="PubMed" id="26842564"/>
            <dbReference type="DOI" id="10.1038/ncomms10612"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN A COMPLEX WITH CDC-48 AND CDT-1</scope>
        <scope>INTERACTION WITH CDC-48 AND CDT-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 582-PHE--LYS-584</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2017" name="Nat. Cell Biol." volume="19" first="468" last="479">
            <title>CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.</title>
            <authorList>
                <person name="Sonneville R."/>
                <person name="Moreno S.P."/>
                <person name="Knebel A."/>
                <person name="Johnson C."/>
                <person name="Hastie C.J."/>
                <person name="Gartner A."/>
                <person name="Gambus A."/>
                <person name="Labib K."/>
            </authorList>
            <dbReference type="PubMed" id="28368371"/>
            <dbReference type="DOI" id="10.1038/ncb3500"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2L056-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_059592"/>
        </isoform>
        <isoform>
            <id>H2L056-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_059593 VSP_059594"/>
        </isoform>
        <isoform>
            <id>H2L056-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_059594"/>
        </isoform>
        <isoform>
            <id>H2L056-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_059593"/>
        </isoform>
        <isoform>
            <id>H2L056-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001300549.1">
        <property type="nucleotide sequence ID" value="NM_001313620.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F48A11.5e">
        <property type="protein sequence ID" value="CE50740"/>
        <property type="gene ID" value="WBGene00018586"/>
        <property type="gene designation" value="ubxn-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F48A11.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F48A11.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F48A11.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F48A11.5d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F48A11.5e"/>
        </source>
    </evidence>
    <sequence length="519" mass="59080" checksum="7C82BFAC5DB5A662" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1997-07-01" modified="2025-10-08" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>O01263</accession>
    <name>O01263_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">hsp-12.1</name>
        <name evidence="4" type="ORF">CELE_T22A3.2</name>
        <name evidence="6" type="ORF">T22A3.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB03380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T25091">
        <property type="entry name" value="T25091"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001076613.1">
        <property type="nucleotide sequence ID" value="NM_001083144.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O01263"/>
    <dbReference type="SMR" id="O01263"/>
    <dbReference type="PeptideAtlas" id="O01263"/>
    <dbReference type="GeneID" id="188710"/>
    <dbReference type="KEGG" id="cel:CELE_T22A3.2"/>
    <dbReference type="UCSC" id="T22A3.2b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011906"/>
    <dbReference type="CTD" id="188710"/>
    <dbReference type="WormBase" id="T22A3.2a">
        <property type="protein sequence ID" value="CE13914"/>
        <property type="gene ID" value="WBGene00011906"/>
        <property type="gene designation" value="hsp-12.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095001_6_0_1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011906">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O01263">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000036">
        <property type="entry name" value="Heat Shock Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF6">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 12.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB03380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="T22A3.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="O01263"/>
        </source>
    </evidence>
    <sequence length="109" mass="12174" checksum="9A1A1DA923306156" modified="1997-07-01" version="1">MHTIPITTDSAASWDWPLQHNDGVVKVTNTSEKFEVGLDAGFFGPNDIDVKVNGIEIIIHLRHDNRPTEYGIVNREVHRTYKLPEDVDPSTVRSHLNSSGVLTITANKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-01-19" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>O01658-2</accession>
    <name>NO66_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66</fullName>
            <ecNumber>1.14.11.-</ecNumber>
            <ecNumber>1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Histone lysine demethylase NO66</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Jumanjic domain protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">jmjc-1</name>
        <name type="ORF">T28F2.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="EMBO J." volume="29" first="727" last="739">
            <title>SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network.</title>
            <authorList>
                <person name="Kirienko N.V."/>
                <person name="Fay D.S."/>
            </authorList>
            <dbReference type="PubMed" id="20057358"/>
            <dbReference type="DOI" id="10.1038/emboj.2009.387"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O01658-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O01658-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_053840 VSP_053839"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="1.14.11.-"/>
    <dbReference type="EC" id="1.14.11.27"/>
    <dbReference type="RefSeq" id="NP_001021645.1">
        <property type="nucleotide sequence ID" value="NM_001026474.4"/>
    </dbReference>
    <dbReference type="WormBase" id="T28F2.4b">
        <property type="protein sequence ID" value="CE37050"/>
        <property type="gene ID" value="WBGene00020902"/>
        <property type="gene designation" value="jmjc-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="125" mass="13980" checksum="329360140C196041" modified="2001-10-01" version="2">MGKKKNSNKSAAAAPAVKHNDRWSSIELGEAKSAAVSHYKEPSKEPKFVHPAKLEKVKRIHDGLNIDRVLSHGPVPKQNGGTKRKHVEVTTQKLENKKPKVEVKKEDEKSKNKKMKNQNKRTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-07-01" modified="2026-01-28" version="182" xmlns="https://uniprot.org/uniprot">
    <accession>O02592</accession>
    <name>O02592_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">ptl-1</name>
        <name evidence="9" type="ORF">CELE_F42G9.9</name>
        <name evidence="11" type="ORF">F42G9.9</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="1996-08" db="EMBL/GenBank/DDBJ databases">
            <title>PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Goedert M."/>
                <person name="Baur C.P."/>
                <person name="Ahringer J."/>
                <person name="Jakes R."/>
                <person name="Hasegawa M."/>
                <person name="Spillantini M.G."/>
                <person name="Smith M.J."/>
                <person name="Hill F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="U67966">
        <property type="protein sequence ID" value="AAB97090.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022576.1">
        <property type="nucleotide sequence ID" value="NM_001027405.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O02592"/>
    <dbReference type="DIP" id="DIP-26628N"/>
    <dbReference type="GeneID" id="175230"/>
    <dbReference type="KEGG" id="cel:CELE_F42G9.9"/>
    <dbReference type="UCSC" id="F42G9.9c.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004212"/>
    <dbReference type="CTD" id="175230"/>
    <dbReference type="WormBase" id="F42G9.9a">
        <property type="protein sequence ID" value="CE24967"/>
        <property type="gene ID" value="WBGene00004212"/>
        <property type="gene designation" value="ptl-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9378527at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004212">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O02592">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF18">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAB97090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD61892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F42G9.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="O02592"/>
        </source>
    </evidence>
    <sequence length="453" mass="49416" checksum="1E779297477B3B1E" modified="1997-07-01" version="1">MSTPQSEPGSEPGSPGENENSMETQYSQGSFPEVAVEPEPEPEPEPEPEPEPEPEPEPEPEPKPKPEVEPVPQPEPEPEYQPEPEPEPEVEPEPEPEPVPEPEPEPEPEPEPVVEKEEEVVVESPPREQEPEKSGKSKPSSPIPDAPTMEDIAPRELESLNFSETSGTSDQQADRIMQNNENERVEEKKQMSPTPSQPQHKTPQRSGIRPPTAILRQPKPIPASLPRPATATPSSQRAISTPRQTASTAPSPRPISKMSRERSDVQKSTSTRSIDNVGRMTPKVNAKFVNVKSKVGSVTNHKAGGGNVEIFSEKRLYNAQSKVGSLKNATHVAGGGNVQIENRKLDFSAASPKVGSKTNYQPAKSDVKIVSEKLTWQAKSKVGSMDNAAHKPAGGNVQILSQKLNWKAESKVGSKDNMNHRPGGGNVQIFDEKIRYVSTDSSRNHSTLDISSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1999-07-15" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>O16264-2</accession>
    <name>PEBPH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Phosphatidylethanolamine-binding protein homolog F40A3.3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">F40A3.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O16264-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_015556"/>
        </isoform>
        <isoform>
            <id>O16264-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379787.1">
        <property type="nucleotide sequence ID" value="NM_001392552.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F40A3.3b">
        <property type="protein sequence ID" value="CE38516"/>
        <property type="gene ID" value="WBGene00018218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="185" mass="20322" checksum="2B13EC2DF11D9BE1" modified="1998-01-01" version="1">MAAEAFTKHEVIPDVLASNPPSKVVSVKFNSGVEANLGNVLTPTQVKDTPEVKWDAEPGALYTLIKTDPDAPSRKEPTYREWHHWLVVNIPGNDIAKGDTLSEYIGAGPPPKTGLHRYVYLIYKQSGRIEDAEHGRLTNTSGDKRGGWKAADFVAKHKLGAPVFGNLFQAEYDDYVPILNKQLGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2026-01-28" version="194" xmlns="https://uniprot.org/uniprot">
    <accession>P29691-2</accession>
    <name>EF2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Elongation factor 2</fullName>
            <shortName>EF-2</shortName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">eef-2</name>
        <name type="ORF">F25H5.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="DNA Cell Biol." volume="10" first="603" last="611">
            <title>Molecular cloning and characterization of the Caenorhabditis elegans elongation factor 2 gene (eft-2).</title>
            <authorList>
                <person name="Ofulue E.N."/>
                <person name="Candido E.P.M."/>
            </authorList>
            <dbReference type="PubMed" id="1930695"/>
            <dbReference type="DOI" id="10.1089/dna.1991.10.603"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Genes Dev." volume="22" first="1025" last="1036">
            <title>Semaphorin controls epidermal morphogenesis by stimulating mRNA translation via eIF2alpha in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Nukazuka A."/>
                <person name="Fujisawa H."/>
                <person name="Inada T."/>
                <person name="Oda Y."/>
                <person name="Takagi S."/>
            </authorList>
            <dbReference type="PubMed" id="18413715"/>
            <dbReference type="DOI" id="10.1101/gad.1644008"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006023" last="E1006023">
            <title>The Caenorhabditis elegans protein FIC-1 is an AMPylase that covalently modifies heat-shock 70 family proteins, translation elongation factors and histones.</title>
            <authorList>
                <person name="Truttmann M.C."/>
                <person name="Cruz V.E."/>
                <person name="Guo X."/>
                <person name="Engert C."/>
                <person name="Schwartz T.U."/>
                <person name="Ploegh H.L."/>
            </authorList>
            <dbReference type="PubMed" id="27138431"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006023"/>
        </citation>
        <scope>AMPYLATION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P29691-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P29691-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_044101"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001367294.1">
        <property type="nucleotide sequence ID" value="NM_001380979.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F25H5.4b">
        <property type="protein sequence ID" value="CE46149"/>
        <property type="gene ID" value="WBGene00001167"/>
        <property type="gene designation" value="eef-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32324"/>
        </source>
    </evidence>
    <sequence length="840" mass="93407" checksum="17D93EA5D98D7B2E" modified="2007-01-23" version="4"> </sequence>
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<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>P34352-2</accession>
    <name>YK86_CAEEL</name>
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        <recommendedName>
            <fullName>Isoform b of Uncharacterized protein C30A5.10</fullName>
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    <gene>
        <name type="ORF">C30A5.10</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34352-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34352-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_041807 VSP_041808"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_498794.3">
        <property type="nucleotide sequence ID" value="NM_066393.7"/>
    </dbReference>
    <dbReference type="WormBase" id="C30A5.10b">
        <property type="protein sequence ID" value="CE46155"/>
        <property type="gene ID" value="WBGene00016242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="466" mass="51747" checksum="06AF24797FC6390A" modified="2011-12-14" version="4" precursor="true">MIRLVFLFLLVVLSVELLDFRSNNYRQIINNALPTIDPQMISQAQAAINPYTDIFVNPPNSFVDFPMANIASSGAFWQQPQSTVSQVAWNPPVSTNPSSSPAASTISFQSYQNPSTFPSTTTASTTTSTTTMPPTYQTTTKSVKKNTETLWTTSKSPMKLSKNPKPSKLNQKSSKSSATSFDSAQLSVLSHRLLNDVLIIPSSRRLYILAIIPIHQSSGQQNFECGEIDVNAIVRMAAFLEAQKTINESNLLKEIGVDIGAIIVDSCSTDLRSVADLYELLSGTNIQKSDLIAIIRDDSTFMPNTEQIIRQLNLPVVNTFFTTRSAVQTSGTLPSMFLPIQSIISALRHYQSTCVNIIFDEKYSESVSEFQQVALTEGICVEVAIHVKNASSTVSEMVVRRLLLSEARIVVALLSEDTWIQMTKALRSEMVIAGRFVFISMQDQRWTTSRKFIESWPTFEQHLISV</sequence>
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<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>P34508-2</accession>
    <name>CRN6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Cell death-related nuclease 6</fullName>
            <ecNumber>3.1.-.-</ecNumber>
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    <gene>
        <name type="primary">crn-6</name>
        <name type="ORF">K04H4.6</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Gene" volume="252" first="155" last="162">
            <title>Deoxyribonuclease II: structure and chromosomal localization of the murine gene, and comparison with the genomic structure of the human and three C. elegans homologs.</title>
            <authorList>
                <person name="Krieser R.J."/>
                <person name="Eastman A."/>
            </authorList>
            <dbReference type="PubMed" id="10903447"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(00)00209-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 18-369 (ISOFORM A)</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Mol. Cell" volume="11" first="987" last="996">
            <title>Functional genomic analysis of apoptotic DNA degradation in C. elegans.</title>
            <authorList>
                <person name="Parrish J.Z."/>
                <person name="Xue D."/>
            </authorList>
            <dbReference type="PubMed" id="12718884"/>
            <dbReference type="DOI" id="10.1016/S1097-2765(03)00095-9"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34508-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34508-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_001304"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="RefSeq" id="NP_001370104.1">
        <property type="nucleotide sequence ID" value="NM_001382961.2"/>
    </dbReference>
    <dbReference type="WormBase" id="K04H4.6a">
        <property type="protein sequence ID" value="CE25043"/>
        <property type="gene ID" value="WBGene00000799"/>
        <property type="gene designation" value="crn-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="373" mass="42866" checksum="3A3CE6BCCE140C18" modified="2002-12-06" version="3" precursor="true">MIRQIILIVSLIGISNAAYQCKDNNGSNVDWFVFYKLPHLWNHPDNVPISNGTGFLYFDVNNKNWKLMPQGMDVENNAVYYTLQQYYNSNMNTTFSYMYNDEWPDSTIWSNSSGHAKGVTVFDQYTGFWMIHSIPKFPSKDMFRFPSNAHYYGQMGICISYNTVSLATIAQQLFYYNTFTYQFNLPQSFANQFPVLSQLKNKEYNKSPPLTSTKVLKSLGGQHFRHFAKTGEWGKDLYSDFVGPTLKSSIKVETWNHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAIDYSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPCTKATAEKVDALANNRYF</sequence>
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<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="209" xmlns="https://uniprot.org/uniprot">
    <accession>P34722-2</accession>
    <name>KPC1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Protein kinase C-like 1</fullName>
            <shortName>PKC</shortName>
            <ecNumber>2.7.11.13</ecNumber>
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        <alternativeName>
            <fullName>Tetradecanoyl phorbol acetate-resistant protein 1</fullName>
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    </protein>
    <gene>
        <name type="primary">tpa-1</name>
        <name type="ORF">B0545.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1989" name="Science" volume="243" first="1713" last="1716">
            <title>Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tabuse Y."/>
                <person name="Nishiwaki K."/>
                <person name="Miwa J."/>
            </authorList>
            <dbReference type="PubMed" id="2538925"/>
            <dbReference type="DOI" id="10.1126/science.2538925"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 148-704</scope>
    </reference>
    <reference key="2">
        <citation type="submission" date="1993-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Miwa J."/>
            </authorList>
        </citation>
        <scope>SEQUENCE REVISION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1995" name="J. Mol. Biol." volume="251" first="477" last="485">
            <title>The tpa-1 gene of Caenorhabditis elegans encodes two proteins similar to Ca(2+)-independent protein kinase Cs: evidence by complete genomic and complementary DNA sequences of the tpa-1 gene.</title>
            <authorList>
                <person name="Sano T."/>
                <person name="Tabuse Y."/>
                <person name="Nishiwaki K."/>
                <person name="Miwa J."/>
            </authorList>
            <dbReference type="PubMed" id="7658466"/>
            <dbReference type="DOI" id="10.1006/jmbi.1995.0449"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Nat. Neurosci." volume="10" first="1300" last="1307">
            <title>Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Van Buskirk C."/>
                <person name="Sternberg P.W."/>
            </authorList>
            <dbReference type="PubMed" id="17891142"/>
            <dbReference type="DOI" id="10.1038/nn1981"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Cell Host Microbe" volume="5" first="341" last="352">
            <title>Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade.</title>
            <authorList>
                <person name="Ziegler K."/>
                <person name="Kurz C.L."/>
                <person name="Cypowyj S."/>
                <person name="Couillault C."/>
                <person name="Pophillat M."/>
                <person name="Pujol N."/>
                <person name="Ewbank J.J."/>
            </authorList>
            <dbReference type="PubMed" id="19380113"/>
            <dbReference type="DOI" id="10.1016/j.chom.2009.03.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-544</scope>
    </reference>
    <reference key="7">
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            <title>Endocannabinoid-Goalpha signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqalpha-PKC-JNK signalling.</title>
            <authorList>
                <person name="Pastuhov S.I."/>
                <person name="Fujiki K."/>
                <person name="Nix P."/>
                <person name="Kanao S."/>
                <person name="Bastiani M."/>
                <person name="Matsumoto K."/>
                <person name="Hisamoto N."/>
            </authorList>
            <dbReference type="PubMed" id="23072806"/>
            <dbReference type="DOI" id="10.1038/ncomms2136"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF LYS-404</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E33887" last="E33887">
            <title>The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression.</title>
            <authorList>
                <person name="Labed S.A."/>
                <person name="Omi S."/>
                <person name="Gut M."/>
                <person name="Ewbank J.J."/>
                <person name="Pujol N."/>
            </authorList>
            <dbReference type="PubMed" id="22470487"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0033887"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-384</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34722-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34722-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_004744"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.13"/>
    <dbReference type="RefSeq" id="NP_001359809.1">
        <property type="nucleotide sequence ID" value="NM_001372684.2"/>
    </dbReference>
    <dbReference type="WormBase" id="B0545.1b">
        <property type="protein sequence ID" value="CE17354"/>
        <property type="gene ID" value="WBGene00006599"/>
        <property type="gene designation" value="tpa-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="567" mass="64919" checksum="DDB9114F649E590E" modified="1997-11-01" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="194" xmlns="https://uniprot.org/uniprot">
    <accession>P54936-2</accession>
    <name>LIN2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform Lin-2b of Protein lin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Abnormal cell lineage protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">lin-2</name>
        <name type="ORF">F17E5.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Development" volume="122" first="97" last="111">
            <title>The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins.</title>
            <authorList>
                <person name="Hoskins R."/>
                <person name="Hajnal A.F."/>
                <person name="Harp S.A."/>
                <person name="Kim S.K."/>
            </authorList>
            <dbReference type="PubMed" id="8565857"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LIN-2A AND LIN-2B)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P54936-2</id>
            <name>Lin-2b</name>
            <sequence type="described" ref="VSP_003154 VSP_003155"/>
        </isoform>
        <isoform>
            <id>P54936-1</id>
            <name>Lin-2a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024588.1">
        <property type="nucleotide sequence ID" value="NM_001029417.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F17E5.1b">
        <property type="protein sequence ID" value="CE27132"/>
        <property type="gene ID" value="WBGene00002991"/>
        <property type="gene designation" value="lin-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="620" mass="69497" checksum="A349E346372A5B5C" modified="1996-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q09320-2</accession>
    <name>YQZ2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Putative metallophosphoesterase F40B5.2</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">F40B5.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09320-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_010626"/>
        </isoform>
        <isoform>
            <id>Q09320-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="455" mass="50449" checksum="91258206742B3981" modified="2004-06-07" version="2">MSSRCKRCLNSFSEMNLKLKIAIIVIGFIHVSIAIARKSTDGVAHHRLVRLHTILITSTAMLSASYYIWKRVNFAITTLLPSPNPVGNRRLRLICFQDIAQALMMLFLFLSHIAMFFYYIFLGPEPNVIAITSLSFIAAYAHILIFLLIADVLFYSTKLIHSKVAPNSVHTYLKENRCYHILLALILGFIFMFAGLYTTHTDPIVRSASIPMKRFQSNSGNVSIALLSDVHIGPSVGRTRIAKIVELTNALKPDIIAIAGDLADGLVRDFHGAAEPLCNLKAPGGVYFATGNHEYMHGNVTEWFWFLENCNITVLHNLNKHITVNGQKLCVAGADDLYALRSNVPGHGMDLRKALGTCNSDSTNILLAHQPNAAKIVLSDSELSKKVNLILSGHTHGGQMYPFVPIVHLANAFVRGQYYDKSTDTYVYVSAGVNYFGPPIKMFGSCEIIFITMTQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2026-01-28" version="154" xmlns="https://uniprot.org/uniprot">
    <accession>Q09969-2</accession>
    <name>BNIP3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of NIP3 homolog</fullName>
            <shortName>CeBNIP3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Daf-16/FOXO controlled germline tumor affecting-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dct-1</name>
        <name evidence="1" type="ORF">C14F5.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Oncogene" volume="17" first="2525" last="2530">
            <title>Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog.</title>
            <authorList>
                <person name="Yasuda M."/>
                <person name="D'Sa-Eipper C."/>
                <person name="Gong X.L."/>
                <person name="Chinnadurai G."/>
            </authorList>
            <dbReference type="PubMed" id="9824163"/>
            <dbReference type="DOI" id="10.1038/sj.onc.1202467"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 12-221 (ISOFORM A)</scope>
        <scope>INTERACTION WITH CED-3 AND CED-9</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Oncogene" volume="19" first="5453" last="5463">
            <title>The C. elegans orthologue ceBNIP3 interacts with CED-9 and CED-3 but kills through a BH3- and caspase-independent mechanism.</title>
            <authorList>
                <person name="Cizeau J."/>
                <person name="Ray R."/>
                <person name="Chen G."/>
                <person name="Gietz R.D."/>
                <person name="Greenberg A.H."/>
            </authorList>
            <dbReference type="PubMed" id="11114722"/>
            <dbReference type="DOI" id="10.1038/sj.onc.1203929"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>HOMODIMER</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH CED-3 AND CED-9</scope>
        <scope>UBIQUITINATION</scope>
        <scope>PROTEASOMAL DEGRADATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Nat. Genet." volume="38" first="251" last="257">
            <title>Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.</title>
            <authorList>
                <person name="Oh S.W."/>
                <person name="Mukhopadhyay A."/>
                <person name="Dixit B.L."/>
                <person name="Raha T."/>
                <person name="Green M.R."/>
                <person name="Tissenbaum H.A."/>
            </authorList>
            <dbReference type="PubMed" id="16380712"/>
            <dbReference type="DOI" id="10.1038/ng1723"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Nat. Genet." volume="39" first="1403" last="1409">
            <title>DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Pinkston-Gosse J."/>
                <person name="Kenyon C."/>
            </authorList>
            <dbReference type="PubMed" id="17934462"/>
            <dbReference type="DOI" id="10.1038/ng.2007.1"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="Nature" volume="521" first="525" last="528">
            <title>Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans.</title>
            <authorList>
                <person name="Palikaras K."/>
                <person name="Lionaki E."/>
                <person name="Tavernarakis N."/>
            </authorList>
            <dbReference type="PubMed" id="25896323"/>
            <dbReference type="DOI" id="10.1038/nature14300"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>UBIQUITINATION AT LYS-26</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09969-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09969-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_037301"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_509340.2">
        <property type="nucleotide sequence ID" value="NM_076939.5"/>
    </dbReference>
    <dbReference type="WormBase" id="C14F5.1b">
        <property type="protein sequence ID" value="CE47263"/>
        <property type="gene ID" value="WBGene00015776"/>
        <property type="gene designation" value="dct-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="C14F5.1a"/>
        </source>
    </evidence>
    <sequence length="218" mass="24568" checksum="2671996898EB4FCA" modified="2012-10-03" version="2">MSSFLEFAKPKMLDIKRKINFASGEKTDESVQPQQQTEQSSAQQTTPSAKAVSNPFITPLTESTPESWVELAPSRTSLCSSVDINMVIIDEKDKDSRLSPVSIAQSPHVEFESLEQVKYKLVREMLPPGKNTDWIWDWSSRPENTPPKTVRMVQYGSNLTTPPNSPEPELYQYLPCESDSLFNVRVVFGFLVTNIFSFVVGAAVGFAVCRKLIKHHRQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="180" xmlns="https://uniprot.org/uniprot">
    <accession>Q17353-2</accession>
    <name>PAR3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Partitioning defective protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Abnormal embryonic partitioning of cytoplasm protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">par-3</name>
        <name type="ORF">F54E7.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1995" name="Cell" volume="83" first="743" last="752">
            <title>Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos.</title>
            <authorList>
                <person name="Etemad-Moghadam B."/>
                <person name="Guo S."/>
                <person name="Kemphues K.J."/>
            </authorList>
            <dbReference type="PubMed" id="8521491"/>
            <dbReference type="DOI" id="10.1016/0092-8674(95)90187-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain evidence="1">Bristol N2</strain>
            <tissue evidence="1">Embryo</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="1996" name="Development" volume="122" first="3133" last="3140">
            <title>par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.</title>
            <authorList>
                <person name="Watts J.L."/>
                <person name="Etemad-Moghadam B."/>
                <person name="Guo S."/>
                <person name="Boyd L."/>
                <person name="Draper B.W."/>
                <person name="Mello C.C."/>
                <person name="Priess J.R."/>
                <person name="Kemphues K.J."/>
            </authorList>
            <dbReference type="PubMed" id="8898226"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PAR-6</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="1998" name="Development" volume="125" first="3607" last="3614">
            <title>Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tabuse Y."/>
                <person name="Izumi Y."/>
                <person name="Piano F."/>
                <person name="Kemphues K.J."/>
                <person name="Miwa J."/>
                <person name="Ohno S."/>
            </authorList>
            <dbReference type="PubMed" id="9716526"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PKC-3</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="1999" name="Development" volume="126" first="127" last="135">
            <title>PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos.</title>
            <authorList>
                <person name="Hung T.-J."/>
                <person name="Kemphues K.J."/>
            </authorList>
            <dbReference type="PubMed" id="9834192"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PAR-6 AND PKC-3</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="journal article" date="2003" name="Development" volume="130" first="5339" last="5350">
            <title>C. elegans PAR-3 and PAR-6 are required for apicobasal asymmetries associated with cell adhesion and gastrulation.</title>
            <authorList>
                <person name="Nance J."/>
                <person name="Munro E.M."/>
                <person name="Priess J.R."/>
            </authorList>
            <dbReference type="PubMed" id="13129846"/>
            <dbReference type="DOI" id="10.1242/dev.00735"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2003" name="Development" volume="130" first="5717" last="5730">
            <title>LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.</title>
            <authorList>
                <person name="Tsou M.-F.B."/>
                <person name="Hayashi A."/>
                <person name="Rose L.S."/>
            </authorList>
            <dbReference type="PubMed" id="14534135"/>
            <dbReference type="DOI" id="10.1242/dev.00790"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2004" name="Development" volume="131" first="2865" last="2874">
            <title>PAR-3 is required for epithelial cell polarity in the distal spermatheca of C. elegans.</title>
            <authorList>
                <person name="Aono S."/>
                <person name="Legouis R."/>
                <person name="Hoose W.A."/>
                <person name="Kemphues K.J."/>
            </authorList>
            <dbReference type="PubMed" id="15151982"/>
            <dbReference type="DOI" id="10.1242/dev.01146"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2008" name="Dev. Cell" volume="15" first="198" last="208">
            <title>A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning.</title>
            <authorList>
                <person name="Panbianco C."/>
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</entry>
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    </dbReference>
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            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAJ43437.1"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="C05C10.5c"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q2XN10</accession>
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        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
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        <name evidence="12" type="ORF">C07A9.3</name>
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            <strain evidence="10 11">Bristol N2</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="861"/>
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            <end position="409"/>
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        <location>
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            <end position="569"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <end position="288"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="613"/>
        </location>
        <ligand>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="C07A9.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="Q2XN10"/>
        </source>
    </evidence>
    <sequence length="893" mass="102009" checksum="8E3F7FBA01A5379D" modified="2005-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2026-01-28" version="165" xmlns="https://uniprot.org/uniprot">
    <accession>Q6ABN8</accession>
    <name>Q6ABN8_CAEEL</name>
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        <recommendedName>
            <fullName evidence="1 10">Mitogen-activated protein kinase</fullName>
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        <name evidence="15" type="ORF">C04G6.1</name>
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    </gene>
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            <taxon>Metazoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
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    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
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            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
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    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 10"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD63051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021913.1">
        <property type="nucleotide sequence ID" value="NM_001026742.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6ABN8"/>
    <dbReference type="SMR" id="Q6ABN8"/>
    <dbReference type="GeneID" id="173880"/>
    <dbReference type="KEGG" id="cel:CELE_C04G6.1"/>
    <dbReference type="UCSC" id="C04G6.1c.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003402"/>
    <dbReference type="CTD" id="173880"/>
    <dbReference type="WormBase" id="C04G6.1c">
        <property type="protein sequence ID" value="CE36972"/>
        <property type="gene ID" value="WBGene00003402"/>
        <property type="gene designation" value="mpk-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_149_0_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003402">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6ABN8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000553">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="491"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="506"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD63051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="C04G6.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="Q6ABN8"/>
        </source>
    </evidence>
    <sequence length="570" mass="65125" checksum="2C8FF7C548559FDD" modified="2004-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-08-16" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6BET1</accession>
    <name>Q6BET1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphotransferase</fullName>
            <ecNumber evidence="14">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">hxk-1</name>
        <name evidence="17" type="ORF">CELE_F14B4.2</name>
        <name evidence="19" type="ORF">F14B4.2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-mannose + ATP = D-mannose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11028"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:11029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="14"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAH04733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370182.1">
        <property type="nucleotide sequence ID" value="NM_001383604.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6BET1"/>
    <dbReference type="SMR" id="Q6BET1"/>
    <dbReference type="GeneID" id="172751"/>
    <dbReference type="UCSC" id="F14B4.2b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008780"/>
    <dbReference type="CTD" id="172751"/>
    <dbReference type="WormBase" id="F14B4.2b">
        <property type="protein sequence ID" value="CE36925"/>
        <property type="gene ID" value="WBGene00008780"/>
        <property type="gene designation" value="hxk-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_3_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008780">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6BET1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24019">
        <property type="entry name" value="ASKHA_NBD_HK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000095">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="15">
        <location>
            <begin position="34"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="16">
        <location>
            <begin position="234"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAH04733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="F14B4.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="Q6BET1"/>
        </source>
    </evidence>
    <sequence length="495" mass="54234" checksum="5110D0935E94FD6C" modified="2004-08-16" version="1">MAATGKCSKVRPRFEMLKSMSIQNSIDVSNNQMIQEACQRLVLSDQQLRRIMQSMEKSMEQGLATSTKKVAVKMLPTYVDSVPNGTESGDFLALDLGGTNFRVLHIKLQGKETKMTGKIFRVPESIMRGTGEALFDHIAGCMAKFMGENDLKDAQKLPLGFTFSFPCEQEGLTKGKLVTWTKGFKASGVEGVDVVTLLHEACHRRKDIDIDVVALLNDTVGTLMACAFQENSCQIGVIVGTGTNACYMERLDRIPKLAGYVDEHGVTPEEMIINTEWGAFGDDGALDFLRTEWDEVVDRESINPGQHLYEKMISGMYMGECARVVLEDLAKQGLLFGGNSDAISVPHCFPTKFVSEIDSDLLEDDDRTFQKTYQILEDIGVEMITANDCANVAYVCSLISTRAAHLTAAGIAMLLNRMNKKHVTVGVDGSVYRFHPTYPTLLDAKIGELIVGDIEYKLMLSEDGSGRGAALVAAVATRLKEEKLAASLSSSSSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-08-16" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6BET9</accession>
    <name>Q6BET9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_T25B9.3</name>
        <name evidence="1 3" type="ORF">T25B9.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAH04719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023403.1">
        <property type="nucleotide sequence ID" value="NM_001028232.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6BET9"/>
    <dbReference type="GeneID" id="188881"/>
    <dbReference type="UCSC" id="T25B9.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012009"/>
    <dbReference type="CTD" id="188881"/>
    <dbReference type="WormBase" id="T25B9.3b">
        <property type="protein sequence ID" value="CE36718"/>
        <property type="gene ID" value="WBGene00012009"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1066485_0_0_1"/>
    <dbReference type="OrthoDB" id="5832220at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012009">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6BET9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH04719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T25B9.3b"/>
        </source>
    </evidence>
    <sequence length="154" mass="17457" checksum="66F77E85409EC141" modified="2004-08-16" version="1">MTKQEMVVKTKKTPRDDPKKIEQMVAFIDDLFVTKDNIYIGVGSVFKEIKKISTVIVPELRCSKGVLSPVSQQVIQHASFHFDLSKLPKEDRKCSTICVFPYLRILTENAVTETFRAKEWCGSADEARHLLTSQVPHINVSSILLILSSLTVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2025-10-08" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TZ47</accession>
    <name>Q9TZ47_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">cbn-1</name>
        <name evidence="10" type="ORF">CELE_K01A2.11</name>
        <name evidence="12" type="ORF">K01A2.11</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T33651">
        <property type="entry name" value="T33651"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_493712.1">
        <property type="nucleotide sequence ID" value="NM_061311.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9TZ47"/>
    <dbReference type="SMR" id="Q9TZ47"/>
    <dbReference type="GeneID" id="173423"/>
    <dbReference type="UCSC" id="K01A2.11d">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019285"/>
    <dbReference type="CTD" id="173423"/>
    <dbReference type="WormBase" id="K01A2.11b">
        <property type="protein sequence ID" value="CE19521"/>
        <property type="gene ID" value="WBGene00019285"/>
        <property type="gene designation" value="cbn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019285">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9TZ47">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF98">
        <property type="entry name" value="45 KDA CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004334025" evidence="8">
        <location>
            <begin position="19"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD61963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="K01A2.11b"/>
        </source>
    </evidence>
    <sequence length="482" mass="54044" checksum="A46B1244BCD626DC" modified="2000-05-01" version="1">MRITVLILSTLLVTILNGLPIVPVVEDSISPEEVPEPSPEIEENTVPPPRVISPRVDVSVDVNEDGVLDIDEIRYAAFVHHGLSASVVEDLFKQVDTNRDNVLDAREFDAIRMLVLEKAENAALRYLQNVDTDRDGLLSLQEAQIYLLREYGIGYHDVARLWKLVPADLSDRMNSTLFSKLRRRVRGMTIRLARQIMKNADLNGDGHISVDEAQAIAFEQEGIGAGDVASMVGSVDENMDGELNAPEFADFERIIRARAIENSKKAMRVVDADNSGTLTLDEAKRVAFEHYGFDEATLAPFFGQADENEDGQLDNVEFAGFRSVIRARSVRDAMDKMKRIDTNGDGLVSNAEATDSTKKEDDMDSEETLALFNIADQNKSGKLDKVELADFNRLVRLSSIKFATDHFKEFDLDGNDAVTFDEIALLIEQKYGIPRSMIKTFFDRIDVDGSGDLMPAEIVDFRHLIRNHVSQQRQEKVYFLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TZ55</accession>
    <name>Q9TZ55_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MiRP K channel accessory Subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mps-2</name>
        <name evidence="2" type="ORF">CELE_K01A2.8</name>
        <name evidence="4" type="ORF">K01A2.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T33643">
        <property type="entry name" value="T33643"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379579.1">
        <property type="nucleotide sequence ID" value="NM_001392991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9TZ55"/>
    <dbReference type="GeneID" id="173419"/>
    <dbReference type="UCSC" id="K01A2.8d">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019282"/>
    <dbReference type="CTD" id="173419"/>
    <dbReference type="WormBase" id="K01A2.8a">
        <property type="protein sequence ID" value="CE19516"/>
        <property type="gene ID" value="WBGene00019282"/>
        <property type="gene designation" value="mps-2"/>
    </dbReference>
    <dbReference type="OMA" id="LYSAWAT"/>
    <dbReference type="OrthoDB" id="5815851at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019282">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9TZ55">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050920">
        <property type="term" value="P:regulation of chemotaxis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD61957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K01A2.8a"/>
        </source>
    </evidence>
    <sequence length="159" mass="18496" checksum="3E60E9AB5231DCC0" modified="2000-05-01" version="1">MPDRRLAIVSFHSLFIYSSFDKMSETKKNVLLSLHSLSSLIHVAMFYFLLVQWSKADNPVLTHFQIFCLVIIGIGFLIILILIFSIFKSEMKSDSHARRFFHIWPLVHIALSTAYQLFTQIVISHWKTYQIPILYSSYATTVSVCIHLVLHSMAVFWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2026-01-28" version="186" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TZ65</accession>
    <name>Q9TZ65_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CELE_F56F11.4</name>
        <name evidence="12 14" type="ORF">F56F11.4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD72012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9TZ65"/>
    <dbReference type="SMR" id="Q9TZ65"/>
    <dbReference type="UCSC" id="F56F11.4b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018991"/>
    <dbReference type="WormBase" id="F56F11.4a">
        <property type="protein sequence ID" value="CE28467"/>
        <property type="gene ID" value="WBGene00018991"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_1_1"/>
    <dbReference type="OrthoDB" id="1154031at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018991">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9TZ65">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="26S protease regulatory subunit 8"/>
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    </dbReference>
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        <property type="entry name" value="26S protease regulatory subunit 8"/>
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        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="187"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD72012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F56F11.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q9TZ65"/>
        </source>
    </evidence>
    <sequence length="411" mass="45690" checksum="2F3F7566E17926C3" modified="2001-10-01" version="2">MGPAPVFPNSRKPATLDANSDEQTLRPYFKTKVEQAEQTVAEKSINVRRLMAQQKELNGKVRLLKEEISHLHEQGSHVGEVCKAMDKKKVLVKNHPDGKYIVDVAASVDISTLAAGTRVALRADNYAIHEVLPSKVDPLVSLMMVEKVPDSTYEMVGGLDTQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGSRGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPAPDEKARAQILKIHSRKMNLMRGIRMDKIAEQIPGASGAEVKSVCTEAGMFALRERRIHVTQEDFEMAVGKVMQKDSEKNMSIKKLWK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-01-31" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q9U3D6-2</accession>
    <name>ADR1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform d of A-to-I RNA editing regulator adr-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adr-1</name>
        <name evidence="5" type="ORF">H15N14.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2002" name="EMBO J." volume="21" first="6025" last="6035">
            <title>RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tonkin L.A."/>
                <person name="Saccomanno L."/>
                <person name="Morse D.P."/>
                <person name="Brodigan T."/>
                <person name="Krause M."/>
                <person name="Bass B.L."/>
            </authorList>
            <dbReference type="PubMed" id="12426375"/>
            <dbReference type="DOI" id="10.1093/emboj/cdf607"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS C; D; E; F AND G)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2002" name="Mol. Cell" volume="10" first="809" last="817">
            <title>The role of RNA editing by ADARs in RNAi.</title>
            <authorList>
                <person name="Knight S.W."/>
                <person name="Bass B.L."/>
            </authorList>
            <dbReference type="PubMed" id="12419225"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ROLE IN TRANSGENE SILENCING</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2003" name="Science" volume="302" first="1725" last="1725">
            <title>Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants.</title>
            <authorList>
                <person name="Tonkin L.A."/>
                <person name="Bass B.L."/>
            </authorList>
            <dbReference type="PubMed" id="14657490"/>
            <dbReference type="DOI" id="10.1126/science.1091340"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2008" name="RNA" volume="14" first="2050" last="2060">
            <title>C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes.</title>
            <authorList>
                <person name="Hundley H.A."/>
                <person name="Krauchuk A.A."/>
                <person name="Bass B.L."/>
            </authorList>
            <dbReference type="PubMed" id="18719245"/>
            <dbReference type="DOI" id="10.1261/rna.1165008"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2009" name="PLoS ONE" volume="4" first="E8210" last="E8210">
            <title>RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.</title>
            <authorList>
                <person name="Sebastiani P."/>
                <person name="Montano M."/>
                <person name="Puca A."/>
                <person name="Solovieff N."/>
                <person name="Kojima T."/>
                <person name="Wang M.C."/>
                <person name="Melista E."/>
                <person name="Meltzer M."/>
                <person name="Fischer S.E."/>
                <person name="Andersen S."/>
                <person name="Hartley S.H."/>
                <person name="Sedgewick A."/>
                <person name="Arai Y."/>
                <person name="Bergman A."/>
                <person name="Barzilai N."/>
                <person name="Terry D.F."/>
                <person name="Riva A."/>
                <person name="Anselmi C.V."/>
                <person name="Malovini A."/>
                <person name="Kitamoto A."/>
                <person name="Sawabe M."/>
                <person name="Arai T."/>
                <person name="Gondo Y."/>
                <person name="Steinberg M.H."/>
                <person name="Hirose N."/>
                <person name="Atzmon G."/>
                <person name="Ruvkun G."/>
                <person name="Baldwin C.T."/>
                <person name="Perls T.T."/>
            </authorList>
            <dbReference type="PubMed" id="20011587"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0008210"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="7">
        <citation type="journal article" date="2014" name="Cell Rep." volume="6" first="599" last="607">
            <title>The dsRBP and inactive editor ADR-1 utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome.</title>
            <authorList>
                <person name="Washburn M.C."/>
                <person name="Kakaradov B."/>
                <person name="Sundararaman B."/>
                <person name="Wheeler E."/>
                <person name="Hoon S."/>
                <person name="Yeo G.W."/>
                <person name="Hundley H.A."/>
            </authorList>
            <dbReference type="PubMed" id="24508457"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2014.01.011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ADR-2</scope>
        <scope>MUTAGENESIS OF 223-LYS--LYS-227 AND 584-LYS--LYS-588</scope>
    </reference>
    <reference evidence="2" key="8">
        <citation type="journal article" date="2015" name="Genome Res." volume="25" first="66" last="75">
            <title>Profiling the RNA editomes of wild-type C. elegans and ADAR mutants.</title>
            <authorList>
                <person name="Zhao H.Q."/>
                <person name="Zhang P."/>
                <person name="Gao H."/>
                <person name="He X."/>
                <person name="Dou Y."/>
                <person name="Huang A.Y."/>
                <person name="Liu X.M."/>
                <person name="Ye A.Y."/>
                <person name="Dong M.Q."/>
                <person name="Wei L."/>
            </authorList>
            <dbReference type="PubMed" id="25373143"/>
            <dbReference type="DOI" id="10.1101/gr.176107.114"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="9">
        <citation type="journal article" date="2016" name="RNA" volume="22" first="722" last="728">
            <title>Trans and cis factors affecting A-to-I RNA editing efficiency of a noncoding editing target in C. elegans.</title>
            <authorList>
                <person name="Washburn M.C."/>
                <person name="Hundley H.A."/>
            </authorList>
            <dbReference type="PubMed" id="26917557"/>
            <dbReference type="DOI" id="10.1261/rna.055079.115"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="10">
        <citation type="journal article" date="2017" name="Elife" volume="6" first="0" last="0">
            <title>The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis.</title>
            <authorList>
                <person name="Deffit S.N."/>
                <person name="Yee B.A."/>
                <person name="Manning A.C."/>
                <person name="Rajendren S."/>
                <person name="Vadlamani P."/>
                <person name="Wheeler E.C."/>
                <person name="Domissy A."/>
                <person name="Washburn M.C."/>
                <person name="Yeo G.W."/>
                <person name="Hundley H.A."/>
            </authorList>
            <dbReference type="PubMed" id="28925356"/>
            <dbReference type="DOI" id="10.7554/eLife.28625"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9U3D6-4</id>
            <name evidence="1">f</name>
            <sequence type="described" ref="VSP_059301 VSP_059302"/>
        </isoform>
        <isoform>
            <id>Q9U3D6-2</id>
            <name evidence="1">d</name>
            <sequence type="described" ref="VSP_059305 VSP_059300 VSP_059307 VSP_059306"/>
        </isoform>
        <isoform>
            <id>Q9U3D6-5</id>
            <name evidence="1">g</name>
            <sequence type="described" ref="VSP_059303 VSP_059304"/>
        </isoform>
        <isoform>
            <id>Q9U3D6-1</id>
            <name evidence="1">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9U3D6-3</id>
            <name evidence="1">e</name>
            <sequence type="described" ref="VSP_059300 VSP_059306 VSP_059305"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_492154.2">
        <property type="nucleotide sequence ID" value="NM_059753.5"/>
    </dbReference>
    <dbReference type="WormBase" id="H15N14.1d">
        <property type="protein sequence ID" value="CE33125"/>
        <property type="gene ID" value="WBGene00000079"/>
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            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="H15N14.1c"/>
        </source>
    </evidence>
    <sequence length="100" mass="11464" checksum="DAEAF9328D2DE7E1" modified="2003-03-01" version="2">MDQNPNYNFGYGQAYGSGTDHTSDSTNNYNWASQWSQPESAASLATHTFPQYVSQQQQQQQQQAQQQAQNTYAAMNPISTFMQQQQRAQTFPQKVYLFLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-01-31" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q9U3D6-5</accession>
    <name>ADR1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform g of A-to-I RNA editing regulator adr-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adr-1</name>
        <name evidence="5" type="ORF">H15N14.1</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2002" name="EMBO J." volume="21" first="6025" last="6035">
            <title>RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tonkin L.A."/>
                <person name="Saccomanno L."/>
                <person name="Morse D.P."/>
                <person name="Brodigan T."/>
                <person name="Krause M."/>
                <person name="Bass B.L."/>
            </authorList>
            <dbReference type="PubMed" id="12426375"/>
            <dbReference type="DOI" id="10.1093/emboj/cdf607"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS C; D; E; F AND G)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2002" name="Mol. Cell" volume="10" first="809" last="817">
            <title>The role of RNA editing by ADARs in RNAi.</title>
            <authorList>
                <person name="Knight S.W."/>
                <person name="Bass B.L."/>
            </authorList>
            <dbReference type="PubMed" id="12419225"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ROLE IN TRANSGENE SILENCING</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2003" name="Science" volume="302" first="1725" last="1725">
            <title>Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants.</title>
            <authorList>
                <person name="Tonkin L.A."/>
                <person name="Bass B.L."/>
            </authorList>
            <dbReference type="PubMed" id="14657490"/>
            <dbReference type="DOI" id="10.1126/science.1091340"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2008" name="RNA" volume="14" first="2050" last="2060">
            <title>C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes.</title>
            <authorList>
                <person name="Hundley H.A."/>
                <person name="Krauchuk A.A."/>
                <person name="Bass B.L."/>
            </authorList>
            <dbReference type="PubMed" id="18719245"/>
            <dbReference type="DOI" id="10.1261/rna.1165008"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2009" name="PLoS ONE" volume="4" first="E8210" last="E8210">
            <title>RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.</title>
            <authorList>
                <person name="Sebastiani P."/>
                <person name="Montano M."/>
                <person name="Puca A."/>
                <person name="Solovieff N."/>
                <person name="Kojima T."/>
                <person name="Wang M.C."/>
                <person name="Melista E."/>
                <person name="Meltzer M."/>
                <person name="Fischer S.E."/>
                <person name="Andersen S."/>
                <person name="Hartley S.H."/>
                <person name="Sedgewick A."/>
                <person name="Arai Y."/>
                <person name="Bergman A."/>
                <person name="Barzilai N."/>
                <person name="Terry D.F."/>
                <person name="Riva A."/>
                <person name="Anselmi C.V."/>
                <person name="Malovini A."/>
                <person name="Kitamoto A."/>
                <person name="Sawabe M."/>
                <person name="Arai T."/>
                <person name="Gondo Y."/>
                <person name="Steinberg M.H."/>
                <person name="Hirose N."/>
                <person name="Atzmon G."/>
                <person name="Ruvkun G."/>
                <person name="Baldwin C.T."/>
                <person name="Perls T.T."/>
            </authorList>
            <dbReference type="PubMed" id="20011587"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0008210"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="7">
        <citation type="journal article" date="2014" name="Cell Rep." volume="6" first="599" last="607">
            <title>The dsRBP and inactive editor ADR-1 utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome.</title>
            <authorList>
                <person name="Washburn M.C."/>
                <person name="Kakaradov B."/>
                <person name="Sundararaman B."/>
                <person name="Wheeler E."/>
                <person name="Hoon S."/>
                <person name="Yeo G.W."/>
                <person name="Hundley H.A."/>
            </authorList>
            <dbReference type="PubMed" id="24508457"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2014.01.011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ADR-2</scope>
        <scope>MUTAGENESIS OF 223-LYS--LYS-227 AND 584-LYS--LYS-588</scope>
    </reference>
    <reference evidence="2" key="8">
        <citation type="journal article" date="2015" name="Genome Res." volume="25" first="66" last="75">
            <title>Profiling the RNA editomes of wild-type C. elegans and ADAR mutants.</title>
            <authorList>
                <person name="Zhao H.Q."/>
                <person name="Zhang P."/>
                <person name="Gao H."/>
                <person name="He X."/>
                <person name="Dou Y."/>
                <person name="Huang A.Y."/>
                <person name="Liu X.M."/>
                <person name="Ye A.Y."/>
                <person name="Dong M.Q."/>
                <person name="Wei L."/>
            </authorList>
            <dbReference type="PubMed" id="25373143"/>
            <dbReference type="DOI" id="10.1101/gr.176107.114"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="9">
        <citation type="journal article" date="2016" name="RNA" volume="22" first="722" last="728">
            <title>Trans and cis factors affecting A-to-I RNA editing efficiency of a noncoding editing target in C. elegans.</title>
            <authorList>
                <person name="Washburn M.C."/>
                <person name="Hundley H.A."/>
            </authorList>
            <dbReference type="PubMed" id="26917557"/>
            <dbReference type="DOI" id="10.1261/rna.055079.115"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="10">
        <citation type="journal article" date="2017" name="Elife" volume="6" first="0" last="0">
            <title>The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis.</title>
            <authorList>
                <person name="Deffit S.N."/>
                <person name="Yee B.A."/>
                <person name="Manning A.C."/>
                <person name="Rajendren S."/>
                <person name="Vadlamani P."/>
                <person name="Wheeler E.C."/>
                <person name="Domissy A."/>
                <person name="Washburn M.C."/>
                <person name="Yeo G.W."/>
                <person name="Hundley H.A."/>
            </authorList>
            <dbReference type="PubMed" id="28925356"/>
            <dbReference type="DOI" id="10.7554/eLife.28625"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9U3D6-3</id>
            <name evidence="1">e</name>
            <sequence type="described" ref="VSP_059305 VSP_059306 VSP_059300"/>
        </isoform>
        <isoform>
            <id>Q9U3D6-2</id>
            <name evidence="1">d</name>
            <sequence type="described" ref="VSP_059300 VSP_059306 VSP_059305 VSP_059307"/>
        </isoform>
        <isoform>
            <id>Q9U3D6-1</id>
            <name evidence="1">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9U3D6-4</id>
            <name evidence="1">f</name>
            <sequence type="described" ref="VSP_059302 VSP_059301"/>
        </isoform>
        <isoform>
            <id>Q9U3D6-5</id>
            <name evidence="1">g</name>
            <sequence type="described" ref="VSP_059303 VSP_059304"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_871803.1">
        <property type="nucleotide sequence ID" value="NM_182003.5"/>
    </dbReference>
    <dbReference type="WormBase" id="H15N14.1g">
        <property type="protein sequence ID" value="CE33128"/>
        <property type="gene ID" value="WBGene00000079"/>
        <property type="gene designation" value="adr-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="12426375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAN61049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="H15N14.1c"/>
        </source>
    </evidence>
    <sequence length="115" mass="12944" checksum="AA1AABBC7CDA5712" modified="2003-03-01" version="2">MDQNPNYNFGYGQAYGSGTDHTSDSTNNYNWASQWSQPESAASLATHTFPQYVSQQQQQQQQQAQQQAQNTYAAMNPISTFMQQQQRAQTFPQKKYGQQGGAPKPSAIRNNNFAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q9U539-2</accession>
    <name>OCT1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Organic cation transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>CeOCT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">oct-1</name>
        <name type="ORF">F52F12.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1999" name="Biochim. Biophys. Acta" volume="1418" first="239" last="244">
            <title>Identity of the F52F12.1 gene product in Caenorhabditis elegans as an organic cation transporter.</title>
            <authorList>
                <person name="Wu X."/>
                <person name="Fei Y.-J."/>
                <person name="Huang W."/>
                <person name="Chancy C."/>
                <person name="Leibach F.H."/>
                <person name="Ganapathy V."/>
            </authorList>
            <dbReference type="PubMed" id="10209228"/>
            <dbReference type="DOI" id="10.1016/S0005-2736(99)00020-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-87 AND ASN-98</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9U539-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9U539-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_011122"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021482.1">
        <property type="nucleotide sequence ID" value="NM_001026311.7"/>
    </dbReference>
    <dbReference type="WormBase" id="F52F12.1b">
        <property type="protein sequence ID" value="CE29329"/>
        <property type="gene ID" value="WBGene00003842"/>
        <property type="gene designation" value="oct-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="568" mass="63505" checksum="C0A3E73851F44056" modified="2008-01-15" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XTY7</accession>
    <name>Q9XTY7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Gamma-glutamyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_T03D8.6</name>
        <name evidence="10 12" type="ORF">T03D8.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamyltransferase family.</text>
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    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB07404.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T24378">
        <property type="entry name" value="T24378"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508017.2">
        <property type="nucleotide sequence ID" value="NM_075616.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XTY7"/>
    <dbReference type="SMR" id="Q9XTY7"/>
    <dbReference type="MEROPS" id="T03.009"/>
    <dbReference type="GeneID" id="180364"/>
    <dbReference type="UCSC" id="T03D8.6.1">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00011393"/>
    <dbReference type="CTD" id="180364"/>
    <dbReference type="WormBase" id="T03D8.6a">
        <property type="protein sequence ID" value="CE37271"/>
        <property type="gene ID" value="WBGene00011393"/>
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    <dbReference type="HOGENOM" id="CLU_014813_4_1_1"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="PhylomeDB" id="Q9XTY7"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
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    <dbReference type="Bgee" id="WBGene00011393">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XTY7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
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    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000005">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000006">
        <property type="entry name" value="Protein CBG05566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055262">
        <property type="entry name" value="GGT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF17">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004336904" evidence="9">
        <location>
            <begin position="20"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="404"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="456"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB07404.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="T03D8.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XTY7"/>
        </source>
    </evidence>
    <sequence length="578" mass="63809" checksum="70976AD34B5D3B9E" modified="2004-10-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>S6F533</accession>
    <name>S6F533_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Folliculin DENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">flcn-1</name>
        <name evidence="2" type="ORF">CELE_F22D3.2</name>
        <name evidence="4" type="ORF">F22D3.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDG24101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368185.1">
        <property type="nucleotide sequence ID" value="NM_001381470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6F533"/>
    <dbReference type="SMR" id="S6F533"/>
    <dbReference type="GeneID" id="174134"/>
    <dbReference type="AGR" id="WB:WBGene00017699"/>
    <dbReference type="CTD" id="174134"/>
    <dbReference type="WormBase" id="F22D3.2i">
        <property type="protein sequence ID" value="CE48462"/>
        <property type="gene ID" value="WBGene00017699"/>
        <property type="gene designation" value="flcn-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_934586_0_0_1"/>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017699">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6F533">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12430:FF:000002">
        <property type="entry name" value="FoLliCuliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1730">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044886">
        <property type="entry name" value="FLCN_DENN_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032035">
        <property type="entry name" value="Folliculin_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16692">
        <property type="entry name" value="Folliculin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Folliculin DENN" evidence="1">
        <location>
            <begin position="52"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDG24101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F22D3.2i"/>
        </source>
    </evidence>
    <sequence length="263" mass="29658" checksum="67A83355FF4CA5E8" modified="2013-10-16" version="1">MMRVHEKNESALATEPDDFEGCENETIKGKVSMAQLANLKIIATQLNTCSEPGDLDLLIRHIVTGGQVVVESREKEYCRQFLLAISNLLPIGCIKLATYKEQYLPEYSSRFNLIGGPHNMDIPLEVSDVMVFRVSPRDVSIVDIEQMSLVNCVIEVRRRPENDGSNGPLPRIVNRYRDLLLDSDVTDTILETALRTTREGWMLKAKICYQMTKQLSHPQVFEHITGCGVEDQQVVSYWTAGLSNAYKLHVLTSIQQSQTSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>S6F542</accession>
    <name>S6F542_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PITH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C03H12.1</name>
        <name evidence="1" type="ORF">CELE_C03H12.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDG24106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294785.1">
        <property type="nucleotide sequence ID" value="NM_001307856.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6F542"/>
    <dbReference type="GeneID" id="181659"/>
    <dbReference type="KEGG" id="cel:CELE_C03H12.1"/>
    <dbReference type="AGR" id="WB:WBGene00007284"/>
    <dbReference type="CTD" id="181659"/>
    <dbReference type="WormBase" id="C03H12.1c">
        <property type="protein sequence ID" value="CE15375"/>
        <property type="gene ID" value="WBGene00007284"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379095_0_0_1"/>
    <dbReference type="OrthoDB" id="6380619at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007284">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6F542">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDG24106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C03H12.1c"/>
        </source>
    </evidence>
    <sequence length="265" mass="30398" checksum="0433A289FB4D2175" modified="2013-10-16" version="1">MVVAINSKQEITRYIKSNITRESINCLIRQHHNSADNSFVTESTEIITTKTETPKDIHADAVGESSFVKFVDSTAELLLSRKINVILFMGGIWHSASSSAIAPFHLVANHFKESKNLIDFSIVDVSETKLPYNLNFDQLPKILITSADRSNTYMFLIKVVLFQNSSEASNAKTFVLLSIGLSWTYPEEFMINHTNIARFVLTRPGKIFGRLRWMDSCQGTCRKRAQREMRDDRLQLKRRLGRNVANSVRQRVLLGYYDRMLRMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>S6F574</accession>
    <name>S6F574_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein COX11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">cox-11</name>
        <name evidence="10" type="ORF">CELE_JC8.5</name>
        <name evidence="12" type="ORF">JC8.5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with CNNM4/ACDP4. Interacts with RANBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDG24132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293852.1">
        <property type="nucleotide sequence ID" value="NM_001306923.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6F574"/>
    <dbReference type="SMR" id="S6F574"/>
    <dbReference type="GeneID" id="186814"/>
    <dbReference type="KEGG" id="cel:CELE_JC8.5"/>
    <dbReference type="AGR" id="WB:WBGene00010437"/>
    <dbReference type="CTD" id="186814"/>
    <dbReference type="WormBase" id="JC8.5b">
        <property type="protein sequence ID" value="CE17988"/>
        <property type="gene ID" value="WBGene00010437"/>
        <property type="gene designation" value="cox-11"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045000_1_3_1"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010437">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6F574">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004548222" description="Cytochrome c oxidase assembly protein COX11, mitochondrial" evidence="9">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDG24132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="JC8.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="S6F574"/>
        </source>
    </evidence>
    <sequence length="195" mass="22160" checksum="4D856ACAD7B86B43" modified="2013-10-16" version="1">MSLVIVAIGCTFAAIPAYRIFCEQTSFGGLTQVAKDFDKIANMKKCEDRLIRVQFNSDVPSSMRWEFKPQQHEIYVHPGETALAFYTARNPTDKPIIGISSYNLTPFQAAYYFNKIQCFCFEEQILNPGEQVDLPVFFYIDPDYVNDPALEYLDSILLSYTFFEAKSGLKLPDPFDPKNRPSIAPSPDKVPEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>S6F588</accession>
    <name>S6F588_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">daf-15</name>
        <name evidence="7" type="ORF">C10C5.6</name>
        <name evidence="5" type="ORF">CELE_C10C5.6</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDG24142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293857.1">
        <property type="nucleotide sequence ID" value="NM_001306928.3"/>
    </dbReference>
    <dbReference type="SMR" id="S6F588"/>
    <dbReference type="GeneID" id="177770"/>
    <dbReference type="KEGG" id="cel:CELE_C10C5.6"/>
    <dbReference type="AGR" id="WB:WBGene00000911"/>
    <dbReference type="CTD" id="177770"/>
    <dbReference type="WormBase" id="C10C5.6d">
        <property type="protein sequence ID" value="CE48436"/>
        <property type="gene ID" value="WBGene00000911"/>
        <property type="gene designation" value="daf-15"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000911">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6F588">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="4">
        <location>
            <begin position="67"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1300"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1185"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1300"/>
            <end position="1326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDG24142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C10C5.6d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="S6F588"/>
        </source>
    </evidence>
    <sequence length="1779" mass="202555" checksum="E44DEFEADCCE0588" modified="2013-10-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>S6F595</accession>
    <name>S6F595_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Calcitonin receptor-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">pdfr-1</name>
        <name evidence="17" type="ORF">C13B9.4</name>
        <name evidence="15" type="ORF">CELE_C13B9.4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDG24147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360187.1">
        <property type="nucleotide sequence ID" value="NM_001372610.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6F595"/>
    <dbReference type="SMR" id="S6F595"/>
    <dbReference type="GeneID" id="175942"/>
    <dbReference type="AGR" id="WB:WBGene00015735"/>
    <dbReference type="CTD" id="175942"/>
    <dbReference type="WormBase" id="C13B9.4d">
        <property type="protein sequence ID" value="CE48499"/>
        <property type="gene ID" value="WBGene00015735"/>
        <property type="gene designation" value="pdfr-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5967113at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015735">
        <property type="expression patterns" value="Expressed in larva and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6F595">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15261">
        <property type="entry name" value="7tmB1_PDFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000029">
        <property type="entry name" value="PDF receptor isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF17">
        <property type="entry name" value="PDF RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="51"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="157"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="462"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDG24147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C13B9.4d"/>
        </source>
    </evidence>
    <sequence length="531" mass="60458" checksum="C5F36A2630382F44" modified="2013-10-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCA1</accession>
    <name>U4PCA1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA_int_endo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">tsen-34</name>
        <name evidence="1" type="ORF">CELE_K08D10.12</name>
        <name evidence="3" type="ORF">K08D10.12</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294566.1">
        <property type="nucleotide sequence ID" value="NM_001307637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCA1"/>
    <dbReference type="SMR" id="U4PCA1"/>
    <dbReference type="GeneID" id="259566"/>
    <dbReference type="KEGG" id="cel:CELE_K08D10.12"/>
    <dbReference type="AGR" id="WB:WBGene00019535"/>
    <dbReference type="CTD" id="259566"/>
    <dbReference type="WormBase" id="K08D10.12b">
        <property type="protein sequence ID" value="CE48992"/>
        <property type="gene ID" value="WBGene00019535"/>
        <property type="gene designation" value="tsen-34"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1361532_0_0_1"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019535">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCA1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="K08D10.12b"/>
        </source>
    </evidence>
    <sequence length="36" mass="4300" checksum="2EE1BF063CAB0CA5" modified="2013-12-11" version="1">MRCCNQVKKTLLLATTSSESTQPHYTQCTWFRPEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCA7</accession>
    <name>U4PCA7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gtf-2h1</name>
        <name evidence="1" type="synonym">gtf-2H1</name>
        <name evidence="1" type="ORF">CELE_R02D3.3</name>
        <name evidence="3" type="ORF">R02D3.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368352.1">
        <property type="nucleotide sequence ID" value="NM_001379998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCA7"/>
    <dbReference type="SMR" id="U4PCA7"/>
    <dbReference type="PeptideAtlas" id="U4PCA7"/>
    <dbReference type="GeneID" id="176838"/>
    <dbReference type="AGR" id="WB:WBGene00019821"/>
    <dbReference type="WormBase" id="R02D3.3b">
        <property type="protein sequence ID" value="CE48626"/>
        <property type="gene ID" value="WBGene00019821"/>
        <property type="gene designation" value="gtf-2H1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037467_0_0_1"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019821">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCA7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="R02D3.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="U4PCA7"/>
        </source>
    </evidence>
    <sequence length="141" mass="16642" checksum="D10769453F9B62F3" modified="2013-12-11" version="1">MTRYKALVTDYFQNSSVEDILHRNEMLLDQQEMETWEMEEAMETDNNEVPPPENWCQSAGDLAKVRDVHSAVREICRQFWKSFPPIDKASEEKLNRMAGTLSKYRDDIRNSDISKENLTHCIQMIDLAVDKFEAYEMKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCA8</accession>
    <name>U4PCA8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc transporter ZIP8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">zipt-15</name>
        <name evidence="7" type="ORF">CELE_Y55F3BL.2</name>
        <name evidence="9" type="ORF">Y55F3BL.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294570.1">
        <property type="nucleotide sequence ID" value="NM_001307641.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCA8"/>
    <dbReference type="PeptideAtlas" id="U4PCA8"/>
    <dbReference type="GeneID" id="190312"/>
    <dbReference type="KEGG" id="cel:CELE_Y55F3BL.2"/>
    <dbReference type="AGR" id="WB:WBGene00021936"/>
    <dbReference type="CTD" id="190312"/>
    <dbReference type="WormBase" id="Y55F3BL.2b">
        <property type="protein sequence ID" value="CE48725"/>
        <property type="gene ID" value="WBGene00021936"/>
        <property type="gene designation" value="zipt-15"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_13_4_1"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021936">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCA8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDH93373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y55F3BL.2b"/>
        </source>
    </evidence>
    <sequence length="296" mass="32427" checksum="3C17BFEDA24F7248" modified="2013-12-11" version="1">MDEVDENGVPTHSYLHMAHISILGVYAFFFCDKLIKIILEIRKKNQHIHHRRLSIENPGMTTERSDSTFVTDAGDREEELLRSVLKKGVMSKADIDETEMMTLEDKSGKSMGDQAHGICVHDHSIEFRAGDSAIAAVAWMIVFGDGLHNFIDGISIGAAFAESLHSGLSISLAVLCEEFPHELGDVAILVASGMTLKQALIYNLLSAITCYVGFFIGVGIGELGPDTSKYAFGLAGGMFLYISLACMMPEMKKAMEEALNVSLRHGIYVLFLQSVGLFSGLTLMYIMARYGESISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCB2</accession>
    <name>U4PCB2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y66H1A.8</name>
        <name evidence="1 3" type="ORF">Y66H1A.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294575.1">
        <property type="nucleotide sequence ID" value="NM_001307646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCB2"/>
    <dbReference type="GeneID" id="24105187"/>
    <dbReference type="KEGG" id="cel:CELE_Y66H1A.8"/>
    <dbReference type="AGR" id="WB:WBGene00235263"/>
    <dbReference type="CTD" id="24105187"/>
    <dbReference type="WormBase" id="Y66H1A.8a">
        <property type="protein sequence ID" value="CE48816"/>
        <property type="gene ID" value="WBGene00235263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00235263">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCB2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y66H1A.8a"/>
        </source>
    </evidence>
    <sequence length="19" mass="2186" checksum="656650C01C3140B6" modified="2013-12-11" version="1">MNAVILKIGFSFQGFIERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCB8</accession>
    <name>U4PCB8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cng-2</name>
        <name evidence="3" type="ORF">CELE_Y76B12C.1</name>
        <name evidence="5" type="ORF">Y76B12C.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294580.1">
        <property type="nucleotide sequence ID" value="NM_001307651.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCB8"/>
    <dbReference type="SMR" id="U4PCB8"/>
    <dbReference type="GeneID" id="190732"/>
    <dbReference type="KEGG" id="cel:CELE_Y76B12C.1"/>
    <dbReference type="AGR" id="WB:WBGene00022295"/>
    <dbReference type="CTD" id="190732"/>
    <dbReference type="WormBase" id="Y76B12C.1b">
        <property type="protein sequence ID" value="CE49080"/>
        <property type="gene ID" value="WBGene00022295"/>
        <property type="gene designation" value="cng-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005746_9_0_1"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022295">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCB8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF10">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0407">Ion channel</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y76B12C.1b"/>
        </source>
    </evidence>
    <sequence length="212" mass="24449" checksum="85054A544CBFFB37" modified="2013-12-11" version="1">MLVKQQVYSPNDYLCRKNEKAKEMFIVKKGLLAVIDDDTGVELDSLKEGHTFGELSIVQVKGNILGDRRSVSLRSVGYSDVYVLHQDDVTRLLQEYPEERVRLMENARRMLHSRGLLETNELGEMCETDDGLDDEAMLEFLSVDEQLNRLENIIDSIDTDLANMITSFSYNSVAYKKRVTALENIFNSNKKRIRGDLYNGILKTDYDDRMMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCC4</accession>
    <name>U4PCC4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cleavage and polyadenylation specificity factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cleavage and polyadenylation specificity factor 160 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">cpsf-1</name>
        <name evidence="14" type="ORF">CELE_Y76B12C.7</name>
        <name evidence="16" type="ORF">Y76B12C.7</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">CPSF is a heterotetramer composed of four distinct subunits 160 (cpsf-1), 100 (cpsf-2), 70 (cpsf-3), and 30 kDa (cpsf-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CPSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368311.1">
        <property type="nucleotide sequence ID" value="NM_001380077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCC4"/>
    <dbReference type="SMR" id="U4PCC4"/>
    <dbReference type="PeptideAtlas" id="U4PCC4"/>
    <dbReference type="GeneID" id="177003"/>
    <dbReference type="AGR" id="WB:WBGene00022301"/>
    <dbReference type="CTD" id="177003"/>
    <dbReference type="WormBase" id="Y76B12C.7b">
        <property type="protein sequence ID" value="CE48903"/>
        <property type="gene ID" value="WBGene00022301"/>
        <property type="gene designation" value="cpsf-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002414_0_0_1"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022301">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCC4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002090">
        <property type="entry name" value="Probable cleavage and polyadenylation specificity factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003219">
        <property type="entry name" value="Probable cleavage and polyadenylation specificity factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="9"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="309"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="889"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDH93388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="Y76B12C.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="U4PCC4"/>
        </source>
    </evidence>
    <sequence length="1263" mass="140753" checksum="146D6A77689A79C4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCC9</accession>
    <name>U4PCC9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="ORF">C44B12.6</name>
        <name evidence="6" type="ORF">CELE_C44B12.6</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294590.1">
        <property type="nucleotide sequence ID" value="NM_001307661.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCC9"/>
    <dbReference type="SMR" id="U4PCC9"/>
    <dbReference type="GeneID" id="183438"/>
    <dbReference type="KEGG" id="cel:CELE_C44B12.6"/>
    <dbReference type="AGR" id="WB:WBGene00016639"/>
    <dbReference type="CTD" id="183438"/>
    <dbReference type="WormBase" id="C44B12.6b">
        <property type="protein sequence ID" value="CE49027"/>
        <property type="gene ID" value="WBGene00016639"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152132_0_0_1"/>
    <dbReference type="OrthoDB" id="5802485at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016639">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCC9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH93393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="C44B12.6b"/>
        </source>
    </evidence>
    <sequence length="123" mass="13745" checksum="1A36084B62049A40" modified="2013-12-11" version="1">MLTPKSRDCSEPSIDKSSEVLPDQPLSERSICPYHHILNYDEKRIPAAISEVECSCPHVKVHGGIIHCEPMMYNMRVMLFDDSCDKYVERVQKVALACVPVFSNHISSGTHSHSLPTPPSTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLE5</accession>
    <name>V6CLE5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calnexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">cnx-1</name>
        <name evidence="10" type="ORF">CELE_ZK632.6</name>
        <name evidence="12" type="ORF">ZK632.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDK13427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293601.1">
        <property type="nucleotide sequence ID" value="NM_001306672.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLE5"/>
    <dbReference type="SMR" id="V6CLE5"/>
    <dbReference type="PeptideAtlas" id="V6CLE5"/>
    <dbReference type="GeneID" id="176390"/>
    <dbReference type="AGR" id="WB:WBGene00000567"/>
    <dbReference type="CTD" id="176390"/>
    <dbReference type="WormBase" id="ZK632.6b">
        <property type="protein sequence ID" value="CE49246"/>
        <property type="gene ID" value="WBGene00000567"/>
        <property type="gene designation" value="cnx-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018224_2_1_1"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000567">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLE5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDK13427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="ZK632.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLE5"/>
        </source>
    </evidence>
    <sequence length="440" mass="49142" checksum="2F1AF455482BBF90" modified="2014-02-19" version="1">MFGPDKCGATGKVHLIFRYKNPINGTISEYHANQPTTIGSTYWDDHNTHLFTLVVKPTGEYSVSVDGKSLYYGNMMSDVTPALTPPKQIFDETDLKPVDWDERENIEDESAVKPDDWDENEPQSVVDEAATKPYDWNEEENELIADPEAKKPQDWDEDMDGSWEAPLIDNPACKGLSGCGTWKAPTIKNPKYKGKWIRPKISNPAFKGKWTARLIDNPNYFEPKPFAGLAPITAVGIEMWTMSENILFDNILITSSEEDSSDVAKQTFYVKQKEEYRLAAATGNGNGFFQQIIDATNEKPWLWAVYILCVLLPLVAIGVFCFGKQSKPTPNFAKKSDAYSADDDRVPNLVDDDEEEIIGDEEDDVNQPGPSGSQSNPEPQDEEENAEQQSANSSQSSAAEEEDDEHVVPENEPVKPTEEFAKKSPKNTGGAKRRTARRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLE7</accession>
    <name>V6CLE7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC-type antigen peptide transporter</fullName>
            <ecNumber evidence="11">7.4.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">haf-4</name>
        <name evidence="17" type="ORF">CELE_W04C9.1</name>
        <name evidence="19" type="ORF">W04C9.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65972"/>
            <dbReference type="Rhea" id="RHEA-COMP:16941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:166823"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.4.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:65973"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.14" evidence="11"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293184.1">
        <property type="nucleotide sequence ID" value="NM_001306255.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLE7"/>
    <dbReference type="SMR" id="V6CLE7"/>
    <dbReference type="GeneID" id="171639"/>
    <dbReference type="AGR" id="WB:WBGene00001814"/>
    <dbReference type="CTD" id="171639"/>
    <dbReference type="WormBase" id="W04C9.1b">
        <property type="protein sequence ID" value="CE49215"/>
        <property type="gene ID" value="WBGene00001814"/>
        <property type="gene designation" value="haf-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001814">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLE7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015433">
        <property type="term" value="F:ABC-type peptide antigen transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18572">
        <property type="entry name" value="ABC_6TM_TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000216">
        <property type="entry name" value="HAlF transporter (PGP related)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000140">
        <property type="entry name" value="Lipid A export ATP-binding/permease protein MsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013305">
        <property type="entry name" value="ABC_Tap-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00958">
        <property type="entry name" value="3a01208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF19">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002773">
        <property type="entry name" value="ABC_prm/ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="256"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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        <location>
            <begin position="432"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00034522"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
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        <source>
            <dbReference type="EMBL" id="CDK13374.1"/>
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        <source>
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        <source>
            <dbReference type="WormBase" id="W04C9.1b"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="V6CLE7"/>
        </source>
    </evidence>
    <sequence length="721" mass="80700" checksum="32B772F4662BE584" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLE8</accession>
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        <submittedName>
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        <name evidence="2" type="ORF">CELE_F58F9.9</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13390.1"/>
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    <dbReference type="WormBase" id="F58F9.9b">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074198_0_0_1"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDK13390.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="F58F9.9b"/>
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    <sequence length="269" mass="29891" checksum="547B3F02E1EE0E23" modified="2014-02-19" version="1">MINFCHITFFLLIAGAQALPTCSYDVCAKGGMWTEWATTKPCPTNCGSCAKILYTRKCLSTNIPNCACVGDTTRYIPCNTKTCVYPAQRTCCIPYVPMIINGTSQCGPFPKDTGRSSEAPCCPKDGFWSDWSAYKPNSNNTAYVRSRKCLSGPSGCPCVNPTTTMETRTDCPCRKLVEVGEQVKKTIRYFPMNVVYTDKSCTAYQDLKAFNEVIRYVRPDGTIGEERMSDCVSGGDQRATVFCDTTTLYYRLDINNDEIIGFSQLNILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLE9</accession>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
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        <text evidence="4">Involved in signal transduction through the Wnt pathway.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
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    <dbReference type="AlphaFoldDB" id="V6CLE9"/>
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        <property type="protein sequence ID" value="CE49438"/>
        <property type="gene ID" value="WBGene00015330"/>
        <property type="gene designation" value="pygo-1"/>
    </dbReference>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052475">
        <property type="entry name" value="Wnt_Signal_Transd_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194:SF16">
        <property type="entry name" value="PROTEIN PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194">
        <property type="entry name" value="PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
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        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDK13432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="C02B10.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLE9"/>
        </source>
    </evidence>
    <sequence length="594" mass="62896" checksum="A01D98A61C82A2CC" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLF5</accession>
    <name>V6CLF5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">fkh-7</name>
        <name evidence="13" type="ORF">CELE_F26D12.1</name>
        <name evidence="15" type="ORF">F26D12.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293723.1">
        <property type="nucleotide sequence ID" value="NM_001306794.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLF5"/>
    <dbReference type="SMR" id="V6CLF5"/>
    <dbReference type="GeneID" id="177340"/>
    <dbReference type="AGR" id="WB:WBGene00001439"/>
    <dbReference type="CTD" id="177340"/>
    <dbReference type="WormBase" id="F26D12.1n">
        <property type="protein sequence ID" value="CE49452"/>
        <property type="gene ID" value="WBGene00001439"/>
        <property type="gene designation" value="fkh-7"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830876at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001439">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLF5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20065">
        <property type="entry name" value="FH_FOXP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047412">
        <property type="entry name" value="FH_FOXP1_P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="80"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="80"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDK13400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F26D12.1n"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLF5"/>
        </source>
    </evidence>
    <sequence length="281" mass="31328" checksum="9D2ECEE0A463A0D1" modified="2014-02-19" version="1">MPSFLNHQLSTSSQPSSQQASGSSGPLLQRAASSASTETSPNPDSKSFVPRRSRISDKTVQPIATDIAKNRDFYRTNDVRPPYTYASLIRQAIMESSDCQLTLNEIYTWFTETFAYFRRNAATWKNAVRHNLSLHKCFQRVEQNVKGAVWTVDDSEFYRRRPNRASATRSQPQTPLPDDISQQKLFDTSALSSFLEMQNFDPASLTGDQFQLNGNLDSVLSLLANADVNNPLQMLSAAAAAGNHSGGILEGQLLNNVKEEMMDVSEPHNGHLLREITQNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLF7</accession>
    <name>V6CLF7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">pdr-1</name>
        <name evidence="14" type="ORF">CELE_K08E3.7</name>
        <name evidence="16" type="ORF">K08E3.7</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDK13444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293603.1">
        <property type="nucleotide sequence ID" value="NM_001306674.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLF7"/>
    <dbReference type="SMR" id="V6CLF7"/>
    <dbReference type="GeneID" id="176816"/>
    <dbReference type="KEGG" id="cel:CELE_K08E3.7"/>
    <dbReference type="AGR" id="WB:WBGene00003967"/>
    <dbReference type="CTD" id="176816"/>
    <dbReference type="WormBase" id="K08E3.7c">
        <property type="protein sequence ID" value="CE49203"/>
        <property type="gene ID" value="WBGene00003967"/>
        <property type="gene designation" value="pdr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053601_0_0_1"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003967">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLF7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003977">
        <property type="entry name" value="Parkin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041565">
        <property type="entry name" value="Parkin_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041170">
        <property type="entry name" value="Znf-RING_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17976">
        <property type="entry name" value="zf-RING_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17978">
        <property type="entry name" value="zf-RING_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01475">
        <property type="entry name" value="PARKIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="125"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDK13444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="K08E3.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLF7"/>
        </source>
    </evidence>
    <sequence length="324" mass="37130" checksum="5C7F92595CFF29B3" modified="2014-02-19" version="1">MRDLSLTPATQIMLLRPKFNSHNENGATTAKITTDSSILGSFYVWCKNCDDVKRGKLRVYCQKCSSTSVLVKSEPQNWSDVLKSKRIPAVCEECCTPGLFAEFKFKCLACNDPAAALTHVRGNWQMTECCVCDGKEKVIFDLGCNHITCQFCFRDYLLSQLERFGFVNQPPHGFTIFCPYPGCNRVVQDVHHFHIMGQTSYSEYQRKATERLIAVDDKGVTCPNVSCGQSFFWEPYDDDGRSQCPDCFFSFCRKCFERNCVCQSEDDLTRTTIDATTRRCPKCHVATERNGGCAHIHCTSCGMDWCFKCKTEWKEECQWDHWFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLF9</accession>
    <name>V6CLF9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">him-19</name>
        <name evidence="1" type="ORF">CELE_Y95B8A.11</name>
        <name evidence="3" type="ORF">Y95B8A.11</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293192.1">
        <property type="nucleotide sequence ID" value="NM_001306263.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLF9"/>
    <dbReference type="GeneID" id="190809"/>
    <dbReference type="AGR" id="WB:WBGene00022390"/>
    <dbReference type="CTD" id="190809"/>
    <dbReference type="WormBase" id="Y95B8A.11c">
        <property type="protein sequence ID" value="CE49423"/>
        <property type="gene ID" value="WBGene00022390"/>
        <property type="gene designation" value="him-19"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736151_0_0_1"/>
    <dbReference type="OrthoDB" id="5812938at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022390">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLF9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y95B8A.11c"/>
        </source>
    </evidence>
    <sequence length="107" mass="12547" checksum="3032036EFF413C6D" modified="2014-02-19" version="1">MMDEVFAEKHPRLFPNATNFGFHRSPISLCLKALKEWSRDRIADTRKTLCFYQPERDFRKFLFEASKLFEVVDDDNELEGEVQIKGQSGGCPLITVFNKDRVYKARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLG4</accession>
    <name>V6CLG4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thyroglobulin type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F58F9.6</name>
        <name evidence="1 3" type="ORF">F58F9.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLG4"/>
    <dbReference type="AGR" id="WB:WBGene00019059"/>
    <dbReference type="WormBase" id="F58F9.6b">
        <property type="protein sequence ID" value="CE49398"/>
        <property type="gene ID" value="WBGene00019059"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074198_0_0_1"/>
    <dbReference type="OrthoDB" id="5821553at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019059">
        <property type="expression patterns" value="Expressed in adult organism"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLG4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31936">
        <property type="entry name" value="PROTEIN CBG18744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31936:SF7">
        <property type="entry name" value="SHK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F58F9.6b"/>
        </source>
    </evidence>
    <sequence length="188" mass="20968" checksum="492790736F875332" modified="2014-02-19" version="1">MQCGPLPEEDTDTSKPCCPKGGLWSSWSGYIRNYASNGWERTRSCLSGTAGCQCTGSTVETSNKCPCRAMIDVSDKVKRNLKTFPLSVDYDGNSCTARQNLEYFNNVPTQIVPCNAWKNYLYTAAIRYVTPNDKIVEQRVANCLALGQKQVSLFCDLNSGYWRLVSNNDEVVGFNLINLILSWGSYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLG7</accession>
    <name>V6CLG7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_W03F8.6</name>
        <name evidence="1 3" type="ORF">W03F8.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293717.1">
        <property type="nucleotide sequence ID" value="NM_001306788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="189159"/>
    <dbReference type="AGR" id="WB:WBGene00020995"/>
    <dbReference type="CTD" id="189159"/>
    <dbReference type="WormBase" id="W03F8.6d">
        <property type="protein sequence ID" value="CE49329"/>
        <property type="gene ID" value="WBGene00020995"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800660at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020995">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLG7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="W03F8.6d"/>
        </source>
    </evidence>
    <sequence length="9" mass="923" checksum="946E687455A5B44E" modified="2014-02-19" version="1">MCNSSNGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLG8</accession>
    <name>V6CLG8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin homolog Hsp-60, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hsp-60</name>
        <name evidence="7" type="ORF">CELE_Y22D7AL.5</name>
        <name evidence="9" type="ORF">Y22D7AL.5</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDK13411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293599.1">
        <property type="nucleotide sequence ID" value="NM_001306670.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLG8"/>
    <dbReference type="SMR" id="V6CLG8"/>
    <dbReference type="PeptideAtlas" id="V6CLG8"/>
    <dbReference type="GeneID" id="175316"/>
    <dbReference type="AGR" id="WB:WBGene00002025"/>
    <dbReference type="CTD" id="175316"/>
    <dbReference type="WormBase" id="Y22D7AL.5c">
        <property type="protein sequence ID" value="CE49133"/>
        <property type="gene ID" value="WBGene00002025"/>
        <property type="gene designation" value="hsp-60"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_1"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002025">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLG8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000026">
        <property type="entry name" value="Chaperonin 60 subunit alpha 2 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDK13411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y22D7AL.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLG8"/>
        </source>
    </evidence>
    <sequence length="262" mass="27333" checksum="4B9A0EC6BD36C381" modified="2014-02-19" version="1">MGIATGATIFGDDSNLIKIEDITANDLGEVDEVTITKDDTLLLRGRGDQTEIEKRIEHITDEIEQSTSDYEKEKLNERLAKLSKGVAVLKIGGGSEVEVGEKKDRVTDALCATRAAVEEGIVPGGGVALLRSLTALKNYKAANEDQQIGVNIVKKALTQPIATIVKNAGLEPSSIIDEVTGNSNTSYGYDALNGKFVDMFEAGIIDPTKVVRTALQDASGVASLLATTECVVTEIPKEEAVGGPAGGMGGMGGMGGMGGMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLH2</accession>
    <name>V6CLH2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">fkh-7</name>
        <name evidence="13" type="ORF">CELE_F26D12.1</name>
        <name evidence="15" type="ORF">F26D12.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368377.1">
        <property type="nucleotide sequence ID" value="NM_001380234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLH2"/>
    <dbReference type="SMR" id="V6CLH2"/>
    <dbReference type="GeneID" id="177340"/>
    <dbReference type="AGR" id="WB:WBGene00001439"/>
    <dbReference type="CTD" id="177340"/>
    <dbReference type="WormBase" id="F26D12.1i">
        <property type="protein sequence ID" value="CE49434"/>
        <property type="gene ID" value="WBGene00001439"/>
        <property type="gene designation" value="fkh-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020943_0_0_1"/>
    <dbReference type="OrthoDB" id="5830876at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001439">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLH2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20065">
        <property type="entry name" value="FH_FOXP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047412">
        <property type="entry name" value="FH_FOXP1_P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="80"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="80"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDK13399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F26D12.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLH2"/>
        </source>
    </evidence>
    <sequence length="276" mass="30575" checksum="2E2DCF9D484EF5BE" modified="2014-02-19" version="1">MPSFLNHQLSTSSQPSSQQASGSSGPLLQRAASSASTETSPNPDSKSFVPRRSRISDKTVQPIATDIAKNRDFYRTNDVRPPYTYASLIRQAIMESSDCQLTLNEIYTWFTETFAYFRRNAATWKNAVRHNLSLHKCFQRVEQNVKGAVWTVDDSEFYRRRPNRASATRSQPQTPLPDDNFDPASLTGDQFQLNGNLDSVLSLLANADVNNPLQMLSAAAAAGNHSGGILEGQLLNNVKEEMMDVSEPHNGHLLRVARHIQKASKRPASANPSNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLH3</accession>
    <name>V6CLH3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y65B4BL.7</name>
        <name evidence="2 4" type="ORF">Y65B4BL.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293197.1">
        <property type="nucleotide sequence ID" value="NM_001306268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLH3"/>
    <dbReference type="GeneID" id="3564829"/>
    <dbReference type="KEGG" id="cel:CELE_Y65B4BL.7"/>
    <dbReference type="AGR" id="WB:WBGene00022039"/>
    <dbReference type="CTD" id="3564829"/>
    <dbReference type="WormBase" id="Y65B4BL.7b">
        <property type="protein sequence ID" value="CE49286"/>
        <property type="gene ID" value="WBGene00022039"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097294_0_0_1"/>
    <dbReference type="OrthoDB" id="5820995at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022039">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLH3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y65B4BL.7b"/>
        </source>
    </evidence>
    <sequence length="172" mass="19841" checksum="5E82C6FFC8B2F4CC" modified="2014-02-19" version="1">MIYQSIRDIPRQYRSIICDAFGFSDCLDSLEMQIPIVEYCDLCLRVSMEFMFPVGVLIVFSITQILITVSPGMASRIRNPIPSLASFIYMSFFFKCITNLLTSIAMLPYLGCTDQPSFWGEYLAAGLLGLFWMYSLLNMGVFTRITYHNFIRARENYERQVVRNGMVVELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLH6</accession>
    <name>V6CLH6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_R13H7.2</name>
        <name evidence="8 10" type="ORF">R13H7.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLH6"/>
    <dbReference type="SMR" id="V6CLH6"/>
    <dbReference type="AGR" id="WB:WBGene00020069"/>
    <dbReference type="WormBase" id="R13H7.2e">
        <property type="protein sequence ID" value="CE49409"/>
        <property type="gene ID" value="WBGene00020069"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_24_3_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020069">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLH6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895">
        <property type="entry name" value="PROTEIN CBG20548-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDK13404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="R13H7.2e"/>
        </source>
    </evidence>
    <sequence length="407" mass="47453" checksum="3519346063EFCB1B" modified="2014-02-19" version="1">MINTTMQSEEYLNADVSKWVEKFRREHGGDDSALLTLVPPGLYVTLNKYVFPFQFCFGVIGNVLNLCVLLSRNMRNEANILLSAMAICDIILLVTMLPNSLGVWYPMYMSDWFRKFIFNSNTWTIFLANFCSCITSWLILAVSVERYMGIRSPIHFRYHWRTARVFYLIFSIILGSFLLTFFHTFEYKYGYAMIRNGTKLYGSPVNVDKLVDVPTWVKTMIKTFKILQVVVGVVLPTIGIFIFNMLIVLMLRKSEYFNFRSAETKDENSNRKYSDLEIRQKRDIKVTFTVLAIICCYFVTHIPSVIPFVIELFNYHPDWVKVYAIPISGSWLITGKVANFVLFCMSSVYFRRRLRDLIRGRFDMCGAKKKFSGVSSAQSIKSQAYRLTRFRDRDDIQRQSSCLTQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLH7</accession>
    <name>V6CLH7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">try-3</name>
        <name evidence="6" type="ORF">C43G2.5</name>
        <name evidence="4" type="ORF">CELE_C43G2.5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293737.1">
        <property type="nucleotide sequence ID" value="NM_001306808.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLH7"/>
    <dbReference type="SMR" id="V6CLH7"/>
    <dbReference type="MEROPS" id="S01.B70"/>
    <dbReference type="PeptideAtlas" id="V6CLH7"/>
    <dbReference type="GeneID" id="183420"/>
    <dbReference type="KEGG" id="cel:CELE_C43G2.5"/>
    <dbReference type="AGR" id="WB:WBGene00006621"/>
    <dbReference type="CTD" id="183420"/>
    <dbReference type="WormBase" id="C43G2.5b">
        <property type="protein sequence ID" value="CE49204"/>
        <property type="gene ID" value="WBGene00006621"/>
        <property type="gene designation" value="try-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_13_1_1"/>
    <dbReference type="OrthoDB" id="5844829at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006621">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLH7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF153">
        <property type="entry name" value="SERINE PROTEASE HEPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDK13421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C43G2.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLH7"/>
        </source>
    </evidence>
    <sequence length="263" mass="28654" checksum="12B9D75DFB5B581E" modified="2014-02-19" version="1">MAKLVSYGDNGQGILCGATVIDDFWLVTAAHCALQLQTRSFVYVREPKNNRERSFSVKEAYIHSGYNNQTADNDIALLRISSDLSKLGIKPVCLVHDDSKLLKQYKNGVVIGYGLTLGEDSSGEPKLINSQTLQSTSVPIISDDDCVKTWRFLSLLSVKITGYQICAGAYLHGTAPGDSGGPLLIHKSNGEYVQIGITSYGADGLDGVIDQGKFPGVYTRISKYVPWIQGVIGKTSMRSSVTSSSPIYFNFLPIFSIILTVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLH9</accession>
    <name>V6CLH9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ERCC4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">eme-1</name>
        <name evidence="2" type="ORF">CELE_F56A6.4</name>
        <name evidence="4" type="ORF">F56A6.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293210.1">
        <property type="nucleotide sequence ID" value="NM_001306281.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLH9"/>
    <dbReference type="SMR" id="V6CLH9"/>
    <dbReference type="GeneID" id="171652"/>
    <dbReference type="AGR" id="WB:WBGene00018923"/>
    <dbReference type="CTD" id="171652"/>
    <dbReference type="WormBase" id="F56A6.4c">
        <property type="protein sequence ID" value="CE49126"/>
        <property type="gene ID" value="WBGene00018923"/>
        <property type="gene designation" value="eme-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018923">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLH9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F56A6.4c"/>
        </source>
    </evidence>
    <sequence length="393" mass="44493" checksum="7D2A05D2225CD058" modified="2014-02-19" version="1">MLNLDEMIRQNQTSSYSLCSSSQENTDINVVARPEKRKLTDDEKETQKELRENAKRAREAEKERKTLEKDKKKSEMARRREEKEKDKETRKIEREISAATNSKCELYTFCHVGKTVIDTWHGLEAELSVLYVERKIDNQLKIDTSLGTRIEWRRKCVELREDDSGRSERFEYSSTQNLFAVVVPAETLKDVISSNTLSDFIIEQKSGFQNGGRCTMLIVSFGRAEIAKKKKLHNLSLQIYEQHRAQIVQIETIAELALFTAQYLRSLARQEKKKLDAGSDGGGGGGAGGAGGHKLQYQGDKGIVIGSRSEIVTDWWSKMLTTIDRLSDAQRRAILELIPDPIAAIDKYSKMDYSLAIQEIGELVAENGRRVGPSMAHRILTMLTDETGNSVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLI4</accession>
    <name>V6CLI4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">ptr-11</name>
        <name evidence="9" type="ORF">CELE_F56C11.2</name>
        <name evidence="11" type="ORF">F56C11.2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293213.1">
        <property type="nucleotide sequence ID" value="NM_001306284.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLI4"/>
    <dbReference type="SMR" id="V6CLI4"/>
    <dbReference type="GeneID" id="171609"/>
    <dbReference type="KEGG" id="cel:CELE_F56C11.2"/>
    <dbReference type="AGR" id="WB:WBGene00004225"/>
    <dbReference type="CTD" id="171609"/>
    <dbReference type="WormBase" id="F56C11.2b">
        <property type="protein sequence ID" value="CE49167"/>
        <property type="gene ID" value="WBGene00004225"/>
        <property type="gene designation" value="ptr-11"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002359_2_1_1"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004225">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLI4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000035">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000065">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF108">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="89"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDK13469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F56C11.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLI4"/>
        </source>
    </evidence>
    <sequence length="669" mass="73889" checksum="76F1EE343AD440AD" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLI7</accession>
    <name>V6CLI7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">inx-7</name>
        <name evidence="12" type="synonym">inx</name>
        <name evidence="14" type="ORF">CELE_K02B2.4</name>
        <name evidence="16" type="ORF">K02B2.4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293767.1">
        <property type="nucleotide sequence ID" value="NM_001306838.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLI7"/>
    <dbReference type="GeneID" id="177364"/>
    <dbReference type="AGR" id="WB:WBGene00002129"/>
    <dbReference type="CTD" id="177364"/>
    <dbReference type="WormBase" id="K02B2.4b">
        <property type="protein sequence ID" value="CE49194"/>
        <property type="gene ID" value="WBGene00002129"/>
        <property type="gene designation" value="inx-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035763_0_2_1"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002129">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLI7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF9">
        <property type="entry name" value="INNEXIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="190"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDK13474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="K02B2.4b"/>
        </source>
    </evidence>
    <sequence length="315" mass="36248" checksum="5A1772053C5D9AB6" modified="2014-02-19" version="1">MLPHDRQQNFGFDMWKTIFYGSTNGNETWRENGVFPRVTLCDFETRDMGNVQMHTVQCVLLLNLFTEKIFVFLWAWYILLTAFTVGNLFSWLFAVFNETYNEHFILNHLEMCETPFDKDDLKNREHVTRFITLYLGTDGLFLLQLIAQHADVVFTTELIAALFKTYIEIEAQRATLKQMNAVLPLLRPNDESQVESGKNTAPSTSHNVRRRGTEQLEKNVKSRQGSLSTQLRPFNSFEEPDQPTKKFDDSSSEDENSKKGSKKPSPTKKKASSKNSPQSSSNSRRPSLAHTASPAFTHHHEPDSKIPKTAEKKHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLJ0</accession>
    <name>V6CLJ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransf_21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C43G2.3</name>
        <name evidence="1" type="ORF">CELE_C43G2.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368384.1">
        <property type="nucleotide sequence ID" value="NM_001380282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLJ0"/>
    <dbReference type="GeneID" id="183418"/>
    <dbReference type="KEGG" id="cel:CELE_C43G2.3"/>
    <dbReference type="AGR" id="WB:WBGene00016612"/>
    <dbReference type="CTD" id="183418"/>
    <dbReference type="WormBase" id="C43G2.3b">
        <property type="protein sequence ID" value="CE49135"/>
        <property type="gene ID" value="WBGene00016612"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091819_0_0_1"/>
    <dbReference type="OrthoDB" id="5870198at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016612">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLJ0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C43G2.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLJ0"/>
        </source>
    </evidence>
    <sequence length="108" mass="12440" checksum="5F7F4F68C38B2F87" modified="2014-02-19" version="1">MISVRAIKQMLSGQVDYRYKADTMQMGRFISLDNLKDQKFDPSQHIAIEKIIVNGLSKNINQDFQTCFKSWPKELIADHGIYVSEPLGGQLTQWARMYFEPDQLGEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLJ1</accession>
    <name>V6CLJ1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calmodulin-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">kcnl-2</name>
        <name evidence="11" type="ORF">CELE_F08A10.1</name>
        <name evidence="13" type="ORF">F08A10.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293205.1">
        <property type="nucleotide sequence ID" value="NM_001306276.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLJ1"/>
    <dbReference type="SMR" id="V6CLJ1"/>
    <dbReference type="GeneID" id="172602"/>
    <dbReference type="AGR" id="WB:WBGene00008570"/>
    <dbReference type="CTD" id="172602"/>
    <dbReference type="WormBase" id="F08A10.1k">
        <property type="protein sequence ID" value="CE49268"/>
        <property type="gene ID" value="WBGene00008570"/>
        <property type="gene designation" value="kcnl-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008570">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLJ1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000174">
        <property type="entry name" value="KCNN (Potassium K ChaNNel, calcium activated)-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000183">
        <property type="entry name" value="KCNN (Potassium K ChaNNel, calcium activated)-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004178">
        <property type="entry name" value="CaM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036122">
        <property type="entry name" value="CaM-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02888">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01053">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81327">
        <property type="entry name" value="Small-conductance potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin-binding" evidence="10">
        <location>
            <begin position="563"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDK13436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F08A10.1k"/>
        </source>
    </evidence>
    <sequence length="714" mass="79535" checksum="1E1066BE79C9BD6B" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLJ4</accession>
    <name>V6CLJ4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ztf-3</name>
        <name evidence="13" type="ORF">C53D5.4</name>
        <name evidence="11" type="ORF">CELE_C53D5.4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368397.1">
        <property type="nucleotide sequence ID" value="NM_001381421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLJ4"/>
    <dbReference type="GeneID" id="171617"/>
    <dbReference type="AGR" id="WB:WBGene00016905"/>
    <dbReference type="CTD" id="171617"/>
    <dbReference type="WormBase" id="C53D5.4d">
        <property type="protein sequence ID" value="CE49144"/>
        <property type="gene ID" value="WBGene00016905"/>
        <property type="gene designation" value="ztf-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855904at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016905">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLJ4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDK13479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C53D5.4d"/>
        </source>
    </evidence>
    <sequence length="323" mass="36885" checksum="F556BC1CCE2B07DE" modified="2014-02-19" version="1">MKATGFIQEFTRRLLERSSKNIIKIPDNLSNVNQLTCLVKQFLREQQDLAVKVEKVQENQKNLSDFVKEKLTNCNCHVQLDVRNLLAKEMKLQDLRQDDGLDFSIKLPSTSSTDFTVSLNQVVDADAQQRFDLELLKMFGAGNIPHFQPPPDLYQHHHIPHTSQQVAQENLAMLANVPKLDDNNAYFDTFSPEKSGKRAKKRAAPSSAHEAQPNNGPYKCRDCEKTFRQKHGLNQHLLTHETNGAFECDGCGKRYSRQESVYRHQRSTAECSKYLPLALINGTVARNPVATWDTPTAEILQKHRILFEHTMHKIPESNHCGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLJ6</accession>
    <name>V6CLJ6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pdr-1</name>
        <name evidence="2" type="ORF">CELE_K08E3.7</name>
        <name evidence="4" type="ORF">K08E3.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDK13443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360308.1">
        <property type="nucleotide sequence ID" value="NM_001372678.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLJ6"/>
    <dbReference type="SMR" id="V6CLJ6"/>
    <dbReference type="GeneID" id="176816"/>
    <dbReference type="AGR" id="WB:WBGene00003967"/>
    <dbReference type="CTD" id="176816"/>
    <dbReference type="WormBase" id="K08E3.7b">
        <property type="protein sequence ID" value="CE49347"/>
        <property type="gene ID" value="WBGene00003967"/>
        <property type="gene designation" value="pdr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1143444_0_0_1"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003967">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLJ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21382">
        <property type="entry name" value="RING0_parkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000560">
        <property type="entry name" value="E3 ubiquitin-protein ligase parkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003977">
        <property type="entry name" value="Parkin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041565">
        <property type="entry name" value="Parkin_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17976">
        <property type="entry name" value="zf-RING_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01475">
        <property type="entry name" value="PARKIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K08E3.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLJ6"/>
        </source>
    </evidence>
    <sequence length="243" mass="27471" checksum="208CBDBD4798ED84" modified="2014-02-19" version="1">MSDEISILIQDRKTGQRRNLTLNINITGNIEDLTKDVEKLTEIPSDELEVVFCGKKLSKSTIMRDLSLTPATQIMLLRPKFNSHNENGATTAKITTDSSILGSFYVWCKNCDDVKRGKLRVYCQKCSSTSVLVKSEPQNWSDVLKSKRIPAVCEECCTPGLFAEFKFKCLACNDPAAALTHVRGNWQMTECCVCDGKEKVIFDLGCNHITCQFCFREWYKMCTISTLWVRRRTANTNGKPPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLJ8</accession>
    <name>V6CLJ8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_ZK993.2</name>
        <name evidence="2 4" type="ORF">ZK993.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293201.1">
        <property type="nucleotide sequence ID" value="NM_001306272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLJ8"/>
    <dbReference type="SMR" id="V6CLJ8"/>
    <dbReference type="GeneID" id="191481"/>
    <dbReference type="AGR" id="WB:WBGene00022838"/>
    <dbReference type="CTD" id="191481"/>
    <dbReference type="WormBase" id="ZK993.2b">
        <property type="protein sequence ID" value="CE49302"/>
        <property type="gene ID" value="WBGene00022838"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043864_0_0_1"/>
    <dbReference type="OrthoDB" id="5877120at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022838">
        <property type="expression patterns" value="Expressed in multicellular organism and 1 other cell type or tissue"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZK993.2b"/>
        </source>
    </evidence>
    <sequence length="425" mass="49796" checksum="8C2E453A15D026A4" modified="2014-02-19" version="1">MENLSEILESDDLQGESKPLSCMTKGCGSDLKPRFCVTCALSSGIAEYHPSSGSLRLNHCISEIIIMDKANNFLICADCICNGDHSDHEILKNHEMGDMEAELQFLCSAARGFLMESHMDRGAIDCEILKDQVIKFRKYAVAMQMFLKTENWKRVEDEVMMNDLSVKFNAKIPEIMNAKKKALEMVKSIFTRNRKLRQRHLMYDQLEIQKYLDFTELKKSENSNEKAKAMLQKTIDQFQKCKEIYSKFCVIPLDPADALEIDREIEDKMRKLEDEQKKKTPMEVEEDSKFFKFRALQKEIERVHIQHKTCEKEWLTRRREVFHLISSRYKTISQLEQQLGNVIYTPTANAIWAYEITMKSLQNDKRLIKLFESISELLQARLMASKYFPDVPGKSYEDEIFKRLLVEDYDDQIGISWLQKILFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLJ9</accession>
    <name>V6CLJ9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">nsun-2</name>
        <name evidence="4" type="ORF">CELE_Y48G8AL.5</name>
        <name evidence="6" type="ORF">Y48G8AL.5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293223.1">
        <property type="nucleotide sequence ID" value="NM_001306294.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLJ9"/>
    <dbReference type="PeptideAtlas" id="V6CLJ9"/>
    <dbReference type="GeneID" id="171697"/>
    <dbReference type="AGR" id="WB:WBGene00021686"/>
    <dbReference type="CTD" id="171697"/>
    <dbReference type="WormBase" id="Y48G8AL.5c">
        <property type="protein sequence ID" value="CE49201"/>
        <property type="gene ID" value="WBGene00021686"/>
        <property type="gene designation" value="nsun-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_4_3_1"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021686">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLJ9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDK13484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y48G8AL.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLJ9"/>
        </source>
    </evidence>
    <sequence length="286" mass="32957" checksum="D67A5BB6E2C36D5E" modified="2014-02-19" version="1">MRITPHAQDTGGFFVALIEKVSETSFDPSAANGPAWKKKKMFKDEPFTFLKLDDERWNDIRNHYGVDESFLYQNLFSRRLESNDANSRQLFYANDAVKNFVKENMSKVSIQNAGMKMFSRTEGKVENTRFRLSQEGIRYLFKFMQKQKVKIGTEDMLFMLKSDENLVPLEKLECKGDVRKQQNGTVVVYCDDDEPVCTWVGYHTIAPYISKEERLHLLRMMGVDCAEIELLMKSKRKEKAAQDREAAWARKEEAAKAAEPSSSSTDAPESAETLEIPEENVQEMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>W6RRQ3</accession>
    <name>W6RRQ3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">adpr-1</name>
        <name evidence="3" type="ORF">CELE_Y73E7A.9</name>
        <name evidence="5" type="ORF">Y73E7A.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293410.1">
        <property type="nucleotide sequence ID" value="NM_001306481.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RRQ3"/>
    <dbReference type="SMR" id="W6RRQ3"/>
    <dbReference type="GeneID" id="3565128"/>
    <dbReference type="AGR" id="WB:WBGene00044440"/>
    <dbReference type="CTD" id="3565128"/>
    <dbReference type="WormBase" id="Y73E7A.9d">
        <property type="protein sequence ID" value="CE49532"/>
        <property type="gene ID" value="WBGene00044440"/>
        <property type="gene designation" value="adpr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012381_3_1_1"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044440">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RRQ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM63466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y73E7A.9d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="W6RRQ3"/>
        </source>
    </evidence>
    <sequence length="183" mass="21116" checksum="BA11C60CBEC43889" modified="2014-04-16" version="1">MEHIGLARKCVQKFKEWYPNDTAIEKMEEDVEALTPNDRPELVAPEGVVDYQERYGGSTNHQTDIKEANFFGSRDQYIIAGSDCGHMYIWNRDTSKIQGIFEADDHILNICQPHPDQFMIATAGIDDDILLWQPILERPDAFLSRRVEDPYEFMEKRADGMGGRIHLHMLRDLARDNSQCVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6RRQ8</accession>
    <name>W6RRQ8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C06A6.2</name>
        <name evidence="2" type="ORF">CELE_C06A6.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368436.1">
        <property type="nucleotide sequence ID" value="NM_001380344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RRQ8"/>
    <dbReference type="SMR" id="W6RRQ8"/>
    <dbReference type="PeptideAtlas" id="W6RRQ8"/>
    <dbReference type="GeneID" id="177573"/>
    <dbReference type="AGR" id="WB:WBGene00015507"/>
    <dbReference type="CTD" id="177573"/>
    <dbReference type="WormBase" id="C06A6.2f">
        <property type="protein sequence ID" value="CE03939"/>
        <property type="gene ID" value="WBGene00015507"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_414031_0_0_1"/>
    <dbReference type="OrthoDB" id="5854136at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015507">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RRQ8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM63471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C06A6.2f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="W6RRQ8"/>
        </source>
    </evidence>
    <sequence length="281" mass="30739" checksum="58B847C3D11EFC2B" modified="2014-04-16" version="1">MAASSPSTAFIGMPTTINGNKSIQTVLDNLIAARSKKEDHAASTTSVLQAPNYSELKQMLEKNNILKVDNENGPPLKRVKQEIESPPGSSRMIVYNDTRKTTNAPISTWVPPREDLTAKVKDETVQSVPQRKAQATAVIKSGFPLEKHLKKQAVPSMIPVTSSSIPQRNGILGLNSMILPPSAIQQALLKKMDVPTTTPSMSSTSSSQAQSSMNGVINGNNTEVEDKWTLLGRMIAMMAREIETRDPMSACELTRDLQQVIFQYNMKTLRPKENNSSSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6RRR1</accession>
    <name>W6RRR1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F45E4.5</name>
        <name evidence="1 3" type="ORF">F45E4.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294147.1">
        <property type="nucleotide sequence ID" value="NM_001307218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RRR1"/>
    <dbReference type="GeneID" id="185796"/>
    <dbReference type="AGR" id="WB:WBGene00018470"/>
    <dbReference type="CTD" id="185796"/>
    <dbReference type="WormBase" id="F45E4.5d">
        <property type="protein sequence ID" value="CE24982"/>
        <property type="gene ID" value="WBGene00018470"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5844444at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018470">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RRR1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM63476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F45E4.5d"/>
        </source>
    </evidence>
    <sequence length="107" mass="11422" checksum="9CB5D66B515E2EE6" modified="2014-04-16" version="1">MIIQCQKEGGMAELKSITGDAPYDGVGNAPAPIPQPMGFWGRPRYSPPGHGFDGPYGGPMMGGGGPFPYSPYNRFTSMSSSPYGVHGTTTSNNFSFLGLLRDLIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBC1</accession>
    <name>A0A131MBC1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Activator of G protein Signalling</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">ags-3</name>
        <name evidence="10" type="ORF">CELE_F32A6.4</name>
        <name evidence="12" type="ORF">F32A6.4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CZR14619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370955.1">
        <property type="nucleotide sequence ID" value="NM_001383577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBC1"/>
    <dbReference type="SMR" id="A0A131MBC1"/>
    <dbReference type="GeneID" id="180801"/>
    <dbReference type="AGR" id="WB:WBGene00000092"/>
    <dbReference type="CTD" id="180801"/>
    <dbReference type="WormBase" id="F32A6.4f">
        <property type="protein sequence ID" value="CE51366"/>
        <property type="gene ID" value="WBGene00000092"/>
        <property type="gene designation" value="ags-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000092">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBC1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF1">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CZR14619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F32A6.4f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBC1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18048" checksum="FF6AEF326CF676A8" modified="2016-05-11" version="1">MLAKLQSKRMNDQRVDASVLSSNLDFRVRQVDTEPDNSSTDGSEVLIDLLLNAQGRRMDDQRAPFLPGLNPNGQIILRRLNTDPGNEELDEHLVEWLMRVQGERLDEQRSELPPIKPEGQEEVDKKKEEDVTAIVMRMQAGRLEDQRAHLPNIPTSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBC3</accession>
    <name>A0A131MBC3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DPPIV_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tag-10</name>
        <name evidence="5" type="ORF">C31C9.1</name>
        <name evidence="3" type="ORF">CELE_C31C9.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309536.1">
        <property type="nucleotide sequence ID" value="NM_001322757.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBC3"/>
    <dbReference type="GeneID" id="175011"/>
    <dbReference type="AGR" id="WB:WBGene00006404"/>
    <dbReference type="CTD" id="175011"/>
    <dbReference type="WormBase" id="C31C9.1d">
        <property type="protein sequence ID" value="CE51488"/>
        <property type="gene ID" value="WBGene00006404"/>
        <property type="gene designation" value="tag-10"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006404">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBC3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842:SF1">
        <property type="entry name" value="PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842">
        <property type="entry name" value="PROTEIN TOLB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007283702" evidence="2">
        <location>
            <begin position="24"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CZR14450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C31C9.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBC3"/>
        </source>
    </evidence>
    <sequence length="439" mass="49890" checksum="A6C46304E61ED098" modified="2016-05-11" version="1">MLQLIRMLQRLFVLILVVASVLSSEDRDFRIRTNRVWEEEAPEKQFSGRWQDLETNPYDNVVHFDGETHLANVKQLTFGGMNAEGYFSFDNSKLTLQATGYGTDCDQIYELDLNIDPRLQTLRRISTGLGATTCSYFYKEADNNHRLYAGNWWNVKVDNTTDVSKTCPPKQCANPQTDELKHLCNTSYTWDIFADYDIFKVDRYGNFVQRLTDSPGYDAEGVVSPDGTKIAFTSIRSGDLELYIMDIDGKNLIQITNELGYDGGSFFTPDGKRLIFRASRPKNETEIAKYKKLLSYNLVEPIAMELFIVDIDGQNLRKITNLGEANWAPYMLNDNKRIIFSSNYDTAANGFGAFSLYMVNDDGTGLQQITFGQNQFNSFAMQSYDGKKLVWGSSRNGTMYELNLFIADWIDYPSNTTVAPAAPTVTTTTPGKWWWSRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBD2</accession>
    <name>A0A131MBD2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">frpr-4</name>
        <name evidence="10" type="ORF">C54A12.2</name>
        <name evidence="8" type="ORF">CELE_C54A12.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309545.1">
        <property type="nucleotide sequence ID" value="NM_001322728.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBD2"/>
    <dbReference type="SMR" id="A0A131MBD2"/>
    <dbReference type="GeneID" id="183763"/>
    <dbReference type="KEGG" id="cel:CELE_C54A12.2"/>
    <dbReference type="AGR" id="WB:WBGene00016909"/>
    <dbReference type="CTD" id="183763"/>
    <dbReference type="WormBase" id="C54A12.2c">
        <property type="protein sequence ID" value="CE51431"/>
        <property type="gene ID" value="WBGene00016909"/>
        <property type="gene designation" value="frpr-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016909">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBD2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053352">
        <property type="entry name" value="FMRFamide_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47323">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47323:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="25"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CZR14460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="C54A12.2c"/>
        </source>
    </evidence>
    <sequence length="343" mass="40723" checksum="746CFC5D305E256E" modified="2016-05-11" version="1">MMDSMDFHRIMAFVYLPTILIGLLGNLLSLYAYSRKNRKSMVGFLLYSLSVSDIFLLVFALPLFSIMYLPIWTDEQRSFVVAYTAKYVYPLCMMAKTCSLYIMVLITIERWIAVCRPLEVQIWCRYTTSSYSIAAIITFAVVLNFARFFEFEIEYIDGLAFFRRDLLDSEKHWWYFMFYFIIISIIFDYLVPFVIMFVANMLIISELRRTKKERSLMTIQQQKEQNTTVMLLVITIFFGFCHFFSMALKLAESFVGKFLTIQNIYLEMLGEIFNYLIIIHTASTFFIYYMFSEKFRQIIKGIWNKKRKINRHGSSTKIMYHTEATIIHKPASLKTRYSRISSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBD4</accession>
    <name>A0A131MBD4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GlycosylPhosphatidylinositol Anchor Attachment 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">gpaa-1</name>
        <name evidence="4" type="synonym">hpo-3</name>
        <name evidence="2" type="ORF">CELE_F33D11.9</name>
        <name evidence="4" type="ORF">F33D11.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CZR14443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309530.1">
        <property type="nucleotide sequence ID" value="NM_001322684.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBD4"/>
    <dbReference type="GeneID" id="172256"/>
    <dbReference type="AGR" id="WB:WBGene00018006"/>
    <dbReference type="CTD" id="172256"/>
    <dbReference type="WormBase" id="F33D11.9j">
        <property type="protein sequence ID" value="CE51504"/>
        <property type="gene ID" value="WBGene00018006"/>
        <property type="gene designation" value="gpaa-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018006">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBD4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F33D11.9j"/>
        </source>
    </evidence>
    <sequence length="99" mass="11068" checksum="C1FA99397340C607" modified="2016-05-11" version="1">MFGQLFPTISQDSWLAAAQSIALTAIREDVEFKVNHFFLLCCFGYPIWNMLFACSMRYGPEPQGSLGIFGNGSDDDDGDDDDGPQKTNRGHSTKKNKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBE1</accession>
    <name>A0A131MBE1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">lin-42</name>
        <name evidence="4" type="ORF">CELE_F47F6.1</name>
        <name evidence="6" type="ORF">F47F6.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309561.1">
        <property type="nucleotide sequence ID" value="NM_001322707.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBE1"/>
    <dbReference type="SMR" id="A0A131MBE1"/>
    <dbReference type="GeneID" id="173503"/>
    <dbReference type="AGR" id="WB:WBGene00018572"/>
    <dbReference type="CTD" id="173503"/>
    <dbReference type="WormBase" id="F47F6.1f">
        <property type="protein sequence ID" value="CE51542"/>
        <property type="gene ID" value="WBGene00018572"/>
        <property type="gene designation" value="lin-42"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7788983at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018572">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBE1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000130">
        <property type="entry name" value="Period protein homolog lin-42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050760">
        <property type="entry name" value="Period_circadian_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269:SF16">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="212"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CZR14477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F47F6.1f"/>
        </source>
    </evidence>
    <sequence length="510" mass="56448" checksum="93E24AF5AEE034D8" modified="2016-05-11" version="1">MGIRSPKHTTVEYYKIAPKLRVIERILVKQVTVDTRGNVLHIIEYFELEGERGTISQMEPAGHSSATHNIVVPNANPTQPQPLAPAMREEGATLSPPNTWSSSSVEFLDDADDNRLLFTCTFTLPHGTVLSSATYADGFHEQYLTIGDNFLARLEPKGQSFILSAAAASVKQRIFARVTMPDGALRACELLCEFETDRAKITVLALRSAFSLQASHVSSNFHVFTFITKHSSTCALTHIDYASIPYLGLLPTDLIGKSLLAFVYSPDVHVVRQAHIDLHNSRGKIVKSIADLRLVAHNGSILRCQTEWSAYVNPWTRKMELVVARHRICSLPIGDSDVISSPPPGIQSNTLPPVMAKTFEDELRTIMNKVSSAISSVTFLSSGDGASHRLSSSSVLLVLTLHFYLCASLRRDTRLARRIRRRESGQQRHLSEQKVHMLALRSMAPCQEKECKNDALAGGAVSGTTDELIPRRTFLEFAWNGECNFIGGPVLYGSRRDMVQVLQKPTKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBF0</accession>
    <name>A0A131MBF0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_K02C4.3</name>
        <name evidence="5 7" type="ORF">K02C4.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309571.1">
        <property type="nucleotide sequence ID" value="NM_001322742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBF0"/>
    <dbReference type="GeneID" id="174300"/>
    <dbReference type="AGR" id="WB:WBGene00010502"/>
    <dbReference type="CTD" id="174300"/>
    <dbReference type="WormBase" id="K02C4.3d">
        <property type="protein sequence ID" value="CE51399"/>
        <property type="gene ID" value="WBGene00010502"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010502">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBF0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02665">
        <property type="entry name" value="Peptidase_C19I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF940">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE K02C4.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="168"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="634"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CZR14487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="K02C4.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBF0"/>
        </source>
    </evidence>
    <sequence length="1258" mass="142698" checksum="5224A484949BC72F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBF2</accession>
    <name>A0A131MBF2_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">Rap-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">CELE_F53A10.2</name>
        <name evidence="7 9" type="ORF">F53A10.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309564.1">
        <property type="nucleotide sequence ID" value="NM_001322701.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A131MBF2"/>
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    <dbReference type="CTD" id="173502"/>
    <dbReference type="WormBase" id="F53A10.2d">
        <property type="protein sequence ID" value="CE51450"/>
        <property type="gene ID" value="WBGene00018734"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018734">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBF2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000002">
        <property type="entry name" value="Signal-induced proliferation-associated 1-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF32">
        <property type="entry name" value="RAP GTPASE ACTIVATING PROTEIN 1, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21022">
        <property type="entry name" value="Rap-GAP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="6">
        <location>
            <begin position="222"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="601"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CZR14480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F53A10.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBF2"/>
        </source>
    </evidence>
    <sequence length="681" mass="76621" checksum="9A8AE25F91A374DA" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBF3</accession>
    <name>A0A131MBF3_CAEEL</name>
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        <submittedName>
            <fullName evidence="11">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">nep-8</name>
        <name evidence="11" type="ORF">CELE_F18A12.4</name>
        <name evidence="13" type="ORF">F18A12.4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309549.1">
        <property type="nucleotide sequence ID" value="NM_001322722.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBF3"/>
    <dbReference type="SMR" id="A0A131MBF3"/>
    <dbReference type="GeneID" id="184631"/>
    <dbReference type="AGR" id="WB:WBGene00017553"/>
    <dbReference type="CTD" id="184631"/>
    <dbReference type="WormBase" id="F18A12.4b">
        <property type="protein sequence ID" value="CE51354"/>
        <property type="gene ID" value="WBGene00017553"/>
        <property type="gene designation" value="nep-8"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873741at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017553">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBF3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF7">
        <property type="entry name" value="NEPRILYSIN METALLOPEPTIDASE FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="78"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="449"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CZR14464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F18A12.4b"/>
        </source>
    </evidence>
    <sequence length="647" mass="73991" checksum="2E3946965ABB519C" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H9C2</accession>
    <name>A0A168H9C2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OPA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_H43I07.1</name>
        <name evidence="5 7" type="ORF">H43I07.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="H43I07.1c"/>
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    </evidence>
    <sequence length="214" mass="24200" checksum="F4B0FB2E4932C442" modified="2016-07-06" version="1">MGLPMIQVFMIAARQVSKPIADAVLRYGKDHPVFRNKLLLPIGRGLVRFTSRLRMKRLGLGEPISQAPISESAALEQASDFVQQLVLFSYSVGVFAGYYFYTKMTTPESLKIEDYEEFKQQQERAIKELRLQVESLEQRLAAQQKRNFFSQLGFSKENGDESPPKPSQQAPPPEKPSEEKKPATESLKQRFQRISSLPIDAAASLILDGTYDDD</sequence>
</entry>
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    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
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            <end position="133"/>
        </location>
    </feature>
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        <location>
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            <end position="121"/>
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    <feature type="domain" description="C2" evidence="9">
        <location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <source>
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            <dbReference type="WormBase" id="T10A3.1f"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5E4M2N5</accession>
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        <submittedName>
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        </lineage>
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    <reference evidence="2 3" key="1">
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
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        </source>
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    </dbReference>
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</entry>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="6">
        <location>
            <begin position="511"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH2176178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y42G9A.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4Q9F9"/>
        </source>
    </evidence>
    <sequence length="623" mass="66984" checksum="AC4D2D3E9DFFA1AF" modified="2022-10-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-01-19" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>D1MN62</accession>
    <name>D1MN62_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F54C8.7</name>
        <name evidence="3 5" type="ORF">F54C8.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CBI63223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254995.1">
        <property type="nucleotide sequence ID" value="NM_001268066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D1MN62"/>
    <dbReference type="SMR" id="D1MN62"/>
    <dbReference type="PeptideAtlas" id="D1MN62"/>
    <dbReference type="GeneID" id="176326"/>
    <dbReference type="AGR" id="WB:WBGene00010040"/>
    <dbReference type="CTD" id="176326"/>
    <dbReference type="WormBase" id="F54C8.7c">
        <property type="protein sequence ID" value="CE44293"/>
        <property type="gene ID" value="WBGene00010040"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9994780at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010040">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D1MN62">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07660">
        <property type="entry name" value="BAR_Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000085">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF5">
        <property type="entry name" value="ARFAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="2">
        <location>
            <begin position="41"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBI63223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F54C8.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D1MN62"/>
        </source>
    </evidence>
    <sequence length="257" mass="28990" checksum="802E5D435220E323" modified="2010-01-19" version="1">MMHIDTAQVAAKVESFKKWTIGTFKNSKQQLLEHMGKIDKTVDPEFEAQCEVLKDIHRRYGLVVAAAKNFSHVLTQMAEAEKKLSESFYQLSMKEEQIKAQCTMTSETMRGVGEQAASLDACLRYFISSMETVYNQTITDTLHTIYNTESARIEYDVDRNDISAATNPPQGQLTKNLPVGATEKCEEKKAKYEKLKNDAKIKMRLLEENRISVVAAQLEKLQSALAAYYSGNAKLLEASVRELSFLQSPQPSFIPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-01-19" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>D1MN65</accession>
    <name>D1MN65_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rgs-1</name>
        <name evidence="4" type="ORF">C05B5.7</name>
        <name evidence="2" type="ORF">CELE_C05B5.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CBI63208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255056.1">
        <property type="nucleotide sequence ID" value="NM_001268127.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D1MN65"/>
    <dbReference type="SMR" id="D1MN65"/>
    <dbReference type="PeptideAtlas" id="D1MN65"/>
    <dbReference type="GeneID" id="176415"/>
    <dbReference type="KEGG" id="cel:CELE_C05B5.7"/>
    <dbReference type="AGR" id="WB:WBGene00004344"/>
    <dbReference type="CTD" id="176415"/>
    <dbReference type="WormBase" id="C05B5.7b">
        <property type="protein sequence ID" value="CE44351"/>
        <property type="gene ID" value="WBGene00004344"/>
        <property type="gene designation" value="rgs-1"/>
    </dbReference>
    <dbReference type="OMA" id="GYMGCWC"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="PhylomeDB" id="D1MN65"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004344">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D1MN65">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF264">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING RGS-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="41"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBI63208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C05B5.7b"/>
        </source>
    </evidence>
    <sequence length="247" mass="28340" checksum="5FA3F31A680EA36E" modified="2010-01-19" version="1">MGYMGCWCSNLGRKYSGTVSPQRSVQPEALSYEMVYSWQQSFDTLMSFKSGQKCFAEFLKSEYSDENILFWQACEELKREKNSEKMEEKARIIYEDFISILSPKEVSLDSKVREIVNTNMSRPTQNTFEDAQHQIYQLMARDSYPRFLTSIFYRETLASFGITEMDIGGDEEKEREQRAERARLNVPATAAEGSSKDISMISTAVIAVQYFMQKFIQIARTSSSNSFNSTCDKLTLISDAAYCICQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-01-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>D1MN68</accession>
    <name>D1MN68_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">gpb-1</name>
        <name evidence="4" type="ORF">CELE_F13D12.7</name>
        <name evidence="6" type="ORF">F13D12.7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CBI63214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379508.1">
        <property type="nucleotide sequence ID" value="NM_001393204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D1MN68"/>
    <dbReference type="SMR" id="D1MN68"/>
    <dbReference type="PeptideAtlas" id="D1MN68"/>
    <dbReference type="GeneID" id="174803"/>
    <dbReference type="AGR" id="WB:WBGene00001679"/>
    <dbReference type="CTD" id="174803"/>
    <dbReference type="WormBase" id="F13D12.7b">
        <property type="protein sequence ID" value="CE44352"/>
        <property type="gene ID" value="WBGene00001679"/>
        <property type="gene designation" value="gpb-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D1MN68">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040013">
        <property type="term" value="P:negative regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046662">
        <property type="term" value="P:regulation of egg-laying behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001924">
        <property type="entry name" value="guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBI63214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F13D12.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="D1MN68"/>
        </source>
    </evidence>
    <sequence length="153" mass="16732" checksum="2D28CB0BFFB4A085" modified="2010-01-19" version="1">MSLSLSPDFRTFISGACDASAKLWDIRDGMCKQTFPGHESDINAVAFFPSGNAFATGSDDATCRLFDIRADQELAMYSHDNIICGITSVAFSKSGRLLFAGYDDFNCNVWDSMRQERAGVLAGHDNRVSCLGVTEDGMAVCTGSWDSFLKIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-01-19" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>D1MN85</accession>
    <name>D1MN85_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">eIF-4F 25 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">mRNA cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">ife-1</name>
        <name evidence="10" type="ORF">CELE_F53A2.6</name>
        <name evidence="12" type="ORF">F53A2.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CBI63220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255196.1">
        <property type="nucleotide sequence ID" value="NM_001268267.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D1MN85"/>
    <dbReference type="SMR" id="D1MN85"/>
    <dbReference type="PeptideAtlas" id="D1MN85"/>
    <dbReference type="GeneID" id="176755"/>
    <dbReference type="AGR" id="WB:WBGene00002059"/>
    <dbReference type="CTD" id="176755"/>
    <dbReference type="WormBase" id="F53A2.6a">
        <property type="protein sequence ID" value="CE16098"/>
        <property type="gene ID" value="WBGene00002059"/>
        <property type="gene designation" value="ife-1"/>
    </dbReference>
    <dbReference type="OMA" id="CTKEKRI"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="PhylomeDB" id="D1MN85"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002059">
        <property type="expression patterns" value="Expressed in reproductive system and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D1MN85">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000341">
        <property type="term" value="F:RNA trimethylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001556">
        <property type="term" value="P:oocyte maturation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000017">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBI63220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F53A2.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="D1MN85"/>
        </source>
    </evidence>
    <sequence length="231" mass="26394" checksum="E6F9E1F236CF5A83" modified="2010-01-19" version="1">MSDSEIAFEKLKISGEKEGMTETEQTTAPIYPLKRNWTWWYLNDERNKSWEDRLKKVYTFNTVSEFWALYDAIRPPSGLNALCDYNVFRDDIQPMWEVPENSNGGRWLIVIDKGKTPEMVDAIWLEILMALVGEQFGKDMESICGLVCNVRGKGSKISVWTKDCNDDETNMRIGVVLKEKLMAASKDHSKPLFDVIRYEDHESCQKKTSSVVKAKLSLHSSDAPVAEKSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-01-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>D1MN86</accession>
    <name>D1MN86_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAM65 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y37A1A.4</name>
        <name evidence="4 6" type="ORF">Y37A1A.4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBI63209.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D1MN86"/>
    <dbReference type="SMR" id="D1MN86"/>
    <dbReference type="AGR" id="WB:WBGene00045063"/>
    <dbReference type="WormBase" id="Y37A1A.4c">
        <property type="protein sequence ID" value="CE49900"/>
        <property type="gene ID" value="WBGene00045063"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9999654at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00045063">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D1MN86">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031780">
        <property type="entry name" value="FAM65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026136">
        <property type="entry name" value="RIPOR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15829:SF13">
        <property type="entry name" value="FAM65 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15829">
        <property type="entry name" value="PROTEIN KINASE PKN/PRK1, EFFECTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15903">
        <property type="entry name" value="PL48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM65 N-terminal" evidence="3">
        <location>
            <begin position="96"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBI63209.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y37A1A.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="D1MN86"/>
        </source>
    </evidence>
    <sequence length="968" mass="108686" checksum="087401958D29F550" modified="2014-09-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6T5</accession>
    <name>E1B6T5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reelin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F23B12.4</name>
        <name evidence="3 5" type="ORF">F23B12.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="E1B6T5"/>
    <dbReference type="PeptideAtlas" id="E1B6T5"/>
    <dbReference type="AGR" id="WB:WBGene00009081"/>
    <dbReference type="WormBase" id="F23B12.4c">
        <property type="protein sequence ID" value="CE45303"/>
        <property type="gene ID" value="WBGene00009081"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1483243_0_0_1"/>
    <dbReference type="OrthoDB" id="6418377at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009081">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6T5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF42">
        <property type="entry name" value="DEFENSE PROTEIN L(2)34FC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003143747" evidence="1">
        <location>
            <begin position="18"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="2">
        <location>
            <begin position="9"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBW48363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F23B12.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="E1B6T5"/>
        </source>
    </evidence>
    <sequence length="214" mass="24939" checksum="E481BF19BEFC9E94" modified="2010-11-02" version="1">MLESLLFLVALVPVVVAWPDGAPCVHAAFESMNPLEAVEHQGGLQLSTPPYEIAVDQKCYWRNQPIGLTLQGHNESIWFKGFVIQPFKWNNDQLGERFGQLVRLDDNGSWQQQCFRYQVSATHSHDEKKKHIKMWWKVDDEVDTVQFVATVVKHQTQFWVKSVRSRPLPPCRLNRDGFPNYQAPVPQIPPQVKQFKMETFKVFDSIVRRRPFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6T8</accession>
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        <submittedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
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        <name evidence="1 3" type="primary">try-10</name>
        <name evidence="1" type="ORF">CELE_F15B9.5</name>
        <name evidence="3" type="ORF">F15B9.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256476.1">
        <property type="nucleotide sequence ID" value="NM_001269547.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6T8"/>
    <dbReference type="SMR" id="E1B6T8"/>
    <dbReference type="GeneID" id="179787"/>
    <dbReference type="AGR" id="WB:WBGene00008849"/>
    <dbReference type="CTD" id="179787"/>
    <dbReference type="WormBase" id="F15B9.5b">
        <property type="protein sequence ID" value="CE45371"/>
        <property type="gene ID" value="WBGene00008849"/>
        <property type="gene designation" value="try-10"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143711_0_0_1"/>
    <dbReference type="OrthoDB" id="5790020at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008849">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6T8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBW48360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F15B9.5b"/>
        </source>
    </evidence>
    <sequence length="115" mass="12950" checksum="F3A8011FA6A06591" modified="2010-11-02" version="1">MMVNLSVRRIGKRKYLIAKAVTGSSRACMGDSGSPVYCFVNGKRILVGTVAHIGSFSKMSEQDPSNHISFCRDFEYTFVSDWRESSERVVEILQKYGELYQLNEGQNMCFGSGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6T9</accession>
    <name>E1B6T9_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">try-10</name>
        <name evidence="1" type="ORF">CELE_F15B9.5</name>
        <name evidence="3" type="ORF">F15B9.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
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    </dbReference>
    <dbReference type="RefSeq" id="NP_001256477.1">
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    </dbReference>
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    <dbReference type="SMR" id="E1B6T9"/>
    <dbReference type="GeneID" id="179787"/>
    <dbReference type="AGR" id="WB:WBGene00008849"/>
    <dbReference type="CTD" id="179787"/>
    <dbReference type="WormBase" id="F15B9.5c">
        <property type="protein sequence ID" value="CE45341"/>
        <property type="gene ID" value="WBGene00008849"/>
        <property type="gene designation" value="try-10"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143711_0_0_1"/>
    <dbReference type="OrthoDB" id="5790020at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008849">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6T9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBW48361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F15B9.5c"/>
        </source>
    </evidence>
    <sequence length="57" mass="6748" checksum="CC029AA766434E7F" modified="2010-11-02" version="1">MSEQDPSNHISFCRDFEYTFVSDWRESSERVVEILQKYGELYQLNEGQNMCFGSGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6U0</accession>
    <name>E1B6U0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3149 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C51E3.10</name>
        <name evidence="1" type="ORF">CELE_C51E3.10</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367262.1">
        <property type="nucleotide sequence ID" value="NM_001380738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6U0"/>
    <dbReference type="GeneID" id="3564871"/>
    <dbReference type="AGR" id="WB:WBGene00008255"/>
    <dbReference type="CTD" id="3564871"/>
    <dbReference type="WormBase" id="C51E3.10b">
        <property type="protein sequence ID" value="CE45312"/>
        <property type="gene ID" value="WBGene00008255"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2906186_0_0_1"/>
    <dbReference type="OrthoDB" id="10404907at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6U0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBW48348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C51E3.10b"/>
        </source>
    </evidence>
    <sequence length="19" mass="2254" checksum="E33DD29B6201AB12" modified="2010-11-02" version="1">MDSENNNTVLRTTEDRKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6U1</accession>
    <name>E1B6U1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MUTator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">mut-15</name>
        <name evidence="1" type="ORF">CELE_T01C3.8</name>
        <name evidence="3" type="ORF">T01C3.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256639.1">
        <property type="nucleotide sequence ID" value="NM_001269710.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6U1"/>
    <dbReference type="SMR" id="E1B6U1"/>
    <dbReference type="PeptideAtlas" id="E1B6U1"/>
    <dbReference type="GeneID" id="180000"/>
    <dbReference type="AGR" id="WB:WBGene00011323"/>
    <dbReference type="CTD" id="180000"/>
    <dbReference type="WormBase" id="T01C3.8b">
        <property type="protein sequence ID" value="CE45314"/>
        <property type="gene ID" value="WBGene00011323"/>
        <property type="gene designation" value="mut-15"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_503656_0_0_1"/>
    <dbReference type="OrthoDB" id="5871268at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011323">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6U1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBW48434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T01C3.8b"/>
        </source>
    </evidence>
    <sequence length="472" mass="54758" checksum="1760BF317B2A014C" modified="2010-11-02" version="1">MKFSISGRRGYSPWRTLQDALYCSLGRFHNGEHLFCIHSGPNHEFYYGQPILHSIDRFRSHRKPFPRCIIITTDGKRSKSVMRGLLNKRRSSNSTRPNTHITNLDTTELSNEFMTSNRSRVFIGSFKKIKEYIDKLKNEMEQLDDFISVLRFVIINNAEKLKGNSEFADSLGRLAQTFESSLTRFIFAYHFSSSVASLTETLEFCKGKMERPVLIEADNPRVRDVFSNIECKLVRPISEIASLLPTQESTLENNNISPAIVSQYLTESTQKLKILTMLIKKERDARAADNGRSGRRDKPRRERILVITRTTETCIRVMMYLRLKMQTLAVNLRYNIHKITTCDSEEDVEKRNFEFRTGNLDVLVIDWRSIRAVHRGAVDTIVMFDSPHPLYFQTIMETELQNLASIIGVKLKLYMIIDQNKDFRLVREYLKFLECNKTRAPTWFRDLYQKYLADRQSRTTAAVATATSAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6U2</accession>
    <name>E1B6U2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">enpp-1</name>
        <name evidence="7" type="ORF">C27A7.1</name>
        <name evidence="5" type="ORF">CELE_C27A7.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256405.1">
        <property type="nucleotide sequence ID" value="NM_001269476.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6U2"/>
    <dbReference type="SMR" id="E1B6U2"/>
    <dbReference type="GeneID" id="179663"/>
    <dbReference type="AGR" id="WB:WBGene00007753"/>
    <dbReference type="CTD" id="179663"/>
    <dbReference type="WormBase" id="C27A7.1d">
        <property type="protein sequence ID" value="CE45302"/>
        <property type="gene ID" value="WBGene00007753"/>
        <property type="gene designation" value="enpp-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007753">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6U2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF121">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBW48338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C27A7.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="E1B6U2"/>
        </source>
    </evidence>
    <sequence length="815" mass="91536" checksum="34CC7C68C39874EF" modified="2010-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6U6</accession>
    <name>E1B6U6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FERM domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">frm-10</name>
        <name evidence="4" type="ORF">CELE_F25H9.5</name>
        <name evidence="6" type="ORF">F25H9.5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256508.1">
        <property type="nucleotide sequence ID" value="NM_001269579.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6U6"/>
    <dbReference type="SMR" id="E1B6U6"/>
    <dbReference type="PeptideAtlas" id="E1B6U6"/>
    <dbReference type="GeneID" id="179828"/>
    <dbReference type="AGR" id="WB:WBGene00001496"/>
    <dbReference type="CTD" id="179828"/>
    <dbReference type="WormBase" id="F25H9.5b">
        <property type="protein sequence ID" value="CE45332"/>
        <property type="gene ID" value="WBGene00001496"/>
        <property type="gene designation" value="frm-10"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514132_0_0_1"/>
    <dbReference type="OrthoDB" id="2142533at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001496">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6U6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051594">
        <property type="entry name" value="KRIT1/FRMD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13283:SF10">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13283">
        <property type="entry name" value="KREV INTERACTION TRAPPED 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBW48364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F25H9.5b"/>
        </source>
    </evidence>
    <sequence length="297" mass="33416" checksum="2D598CD51BB29CF5" modified="2010-11-02" version="1">MLLLGRLHLLSLENTIRVAAFLFCLQFGNFDETRHDVAFIRNHIDEILPERTCDSIVATTIFGKAINKKTVQEERLLSEWKNISKIGDKSKKEHDLLMELTQNSSCYGAAWFSAHIEVKRSRASLRNFGHGFAEIEVNVGINDRFLTIVESNSGTLLVHPLEELTWQLEGLQPDQMPYLIVNLSFEEEIKNGNSTTIDISNETTQFLMITGNQTFLIDALLKTMTGRRLDRSSSDSSSSSDSSTSSTKHSRIIESKLDFKNCTAGCNRKLCFAKFKDGKCTEVAGSFKAFYSHGQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6U7</accession>
    <name>E1B6U7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_F25H9.7</name>
        <name evidence="7 9" type="ORF">F25H9.7</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256510.1">
        <property type="nucleotide sequence ID" value="NM_001269581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6U7"/>
    <dbReference type="PeptideAtlas" id="E1B6U7"/>
    <dbReference type="GeneID" id="179830"/>
    <dbReference type="AGR" id="WB:WBGene00009139"/>
    <dbReference type="CTD" id="179830"/>
    <dbReference type="WormBase" id="F25H9.7b">
        <property type="protein sequence ID" value="CE45335"/>
        <property type="gene ID" value="WBGene00009139"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102310_2_0_1"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009139">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6U7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBW48365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F25H9.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="E1B6U7"/>
        </source>
    </evidence>
    <sequence length="100" mass="11655" checksum="308F8444A339C7E8" modified="2010-11-02" version="1">MGDTYVKDEFKRHKTAKPEFVKPFITEWTNYCVMLSKQLSSAGIRKGNIGKDLDSDKMEQLSNEHIQQLVELRVEADKHMGRDDFLQNLQNVTESREKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6U9</accession>
    <name>E1B6U9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM GPCR serpentine receptor class x (Srx) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">srx-125</name>
        <name evidence="3" type="ORF">CELE_F32H5.6</name>
        <name evidence="5" type="ORF">F32H5.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256502.1">
        <property type="nucleotide sequence ID" value="NM_001269573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6U9"/>
    <dbReference type="GeneID" id="185218"/>
    <dbReference type="AGR" id="WB:WBGene00006016"/>
    <dbReference type="CTD" id="185218"/>
    <dbReference type="WormBase" id="F32H5.6c">
        <property type="protein sequence ID" value="CE45378"/>
        <property type="gene ID" value="WBGene00006016"/>
        <property type="gene designation" value="srx-125"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070417_0_0_1"/>
    <dbReference type="OrthoDB" id="5837543at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006016">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46611:SF3">
        <property type="entry name" value="7TM GPCR SERPENTINE RECEPTOR CLASS X (SRX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46611">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBW48421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F32H5.6c"/>
        </source>
    </evidence>
    <sequence length="75" mass="8790" checksum="5DBC158F2AC5C33A" modified="2010-11-02" version="1">MINCTILFKLNSAIWYQFIFLSVSFLSIHALDGSVMLYFHTEIHPQWCRRLLKPKSRTGTIFVNRSKISSFHPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6V0</accession>
    <name>E1B6V0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ifbp-1</name>
        <name evidence="8" type="synonym">tag-260</name>
        <name evidence="6" type="ORF">CELE_M04G12.1</name>
        <name evidence="8" type="ORF">M04G12.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IRF2BP family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256503.1">
        <property type="nucleotide sequence ID" value="NM_001269574.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6V0"/>
    <dbReference type="SMR" id="E1B6V0"/>
    <dbReference type="PeptideAtlas" id="E1B6V0"/>
    <dbReference type="GeneID" id="179817"/>
    <dbReference type="KEGG" id="cel:CELE_M04G12.1"/>
    <dbReference type="AGR" id="WB:WBGene00010867"/>
    <dbReference type="CTD" id="179817"/>
    <dbReference type="WormBase" id="M04G12.1d">
        <property type="protein sequence ID" value="CE45375"/>
        <property type="gene ID" value="WBGene00010867"/>
        <property type="gene designation" value="ifbp-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1134430_0_0_1"/>
    <dbReference type="OrthoDB" id="10065080at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010867">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6V0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd16511">
        <property type="entry name" value="vRING-HC_IRF2BP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1580:FF:000001">
        <property type="entry name" value="interferon regulatory factor 2-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1580">
        <property type="entry name" value="Interferon regulatory factor 2-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044882">
        <property type="entry name" value="I2BP1/2_C3HC4-RING_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057414">
        <property type="entry name" value="Zf-C3HC4_IRF-2BP1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF19">
        <property type="entry name" value="PROTEIN INTERACTING WITH TTK69 AND SIN3A, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25454">
        <property type="entry name" value="zf-C3HC4_IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like C3HC4 zinc finger" evidence="5">
        <location>
            <begin position="111"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBW48423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="M04G12.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="E1B6V0"/>
        </source>
    </evidence>
    <sequence length="245" mass="26509" checksum="85245923D5F02EDB" modified="2010-11-02" version="1">MNNLEQVLTHQRLLQMTQANPRAVDDLIQQSLRSLGPNSHLLAPFMMSMLPSTTYSNPRKRESDEEQKPEIYGKVQRGDAQTTTASPTSTHSPDHPGVKDRRGIAPIERVLRCTLCNERLEDTHFVQCPTVSIHKFCFPCSRSSIKDQCKSSDMYCPSGDKCPLVGSAMPWAFMQGEIAQILGDEYDEFKRTREAHGLAPPMGANAATLAAAAAAAAQNGANQTSPASTTTSAASSTSAATSPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6V1</accession>
    <name>E1B6V1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">gut-2</name>
        <name evidence="9" type="ORF">CELE_T10G3.6</name>
        <name evidence="11" type="ORF">T10G3.6</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256512.1">
        <property type="nucleotide sequence ID" value="NM_001269583.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6V1"/>
    <dbReference type="SMR" id="E1B6V1"/>
    <dbReference type="PeptideAtlas" id="E1B6V1"/>
    <dbReference type="GeneID" id="179833"/>
    <dbReference type="AGR" id="WB:WBGene00001808"/>
    <dbReference type="CTD" id="179833"/>
    <dbReference type="WormBase" id="T10G3.6b">
        <property type="protein sequence ID" value="CE45330"/>
        <property type="gene ID" value="WBGene00001808"/>
        <property type="gene designation" value="gut-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130474_3_0_1"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001808">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6V1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBW48439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="T10G3.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="E1B6V1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6838" checksum="2391A97DB7CD14E4" modified="2010-11-02" version="1">MKLTDITVSDPERFPHMVSVKNCFIRGSVVRYVQLPSDQVDTQLLADSCRKELLDSKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6V2</accession>
    <name>E1B6V2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">High Incidence of Males (Increased X chromosome loss)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">him-5</name>
        <name evidence="2" type="ORF">CELE_D1086.4</name>
        <name evidence="4" type="ORF">D1086.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256556.1">
        <property type="nucleotide sequence ID" value="NM_001269627.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6V2"/>
    <dbReference type="GeneID" id="183932"/>
    <dbReference type="AGR" id="WB:WBGene00001864"/>
    <dbReference type="CTD" id="183932"/>
    <dbReference type="WormBase" id="D1086.4b">
        <property type="protein sequence ID" value="CE45310"/>
        <property type="gene ID" value="WBGene00001864"/>
        <property type="gene designation" value="him-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1103631_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001864">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6V2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBW48354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="D1086.4b"/>
        </source>
    </evidence>
    <sequence length="47" mass="5574" checksum="AE8C0C475D1C73F8" modified="2010-11-02" version="1">MCGRPPTKHRDTEQSQEITGSKKQKIFPTPHEKPAWWSFRIPKKRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6V3</accession>
    <name>E1B6V3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T20D4.11-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_D1086.8</name>
        <name evidence="2 4" type="ORF">D1086.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256558.1">
        <property type="nucleotide sequence ID" value="NM_001269629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6V3"/>
    <dbReference type="SMR" id="E1B6V3"/>
    <dbReference type="PeptideAtlas" id="E1B6V3"/>
    <dbReference type="GeneID" id="179908"/>
    <dbReference type="AGR" id="WB:WBGene00008395"/>
    <dbReference type="CTD" id="179908"/>
    <dbReference type="WormBase" id="D1086.8b">
        <property type="protein sequence ID" value="CE45349"/>
        <property type="gene ID" value="WBGene00008395"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1462597_0_0_1"/>
    <dbReference type="OrthoDB" id="5771518at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008395">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6V3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002542">
        <property type="entry name" value="T20D4.11-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01579">
        <property type="entry name" value="DUF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T20D4.11-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBW48355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="D1086.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="E1B6V3"/>
        </source>
    </evidence>
    <sequence length="79" mass="9369" checksum="BEB308183EF1C4E5" modified="2010-11-02" version="1">MLYLTGGFYACSQKLKNRKDNSLCVENFFDNAEVSKDTQCTNWSDNRACLKWTIRDACGRSYWKQYKPYWHLKHSLMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6V6</accession>
    <name>E1B6V6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TransThyretin-Related family domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ttr-12</name>
        <name evidence="5" type="ORF">CELE_F46B3.4</name>
        <name evidence="7" type="ORF">F46B3.4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256934.1">
        <property type="nucleotide sequence ID" value="NM_001270005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6V6"/>
    <dbReference type="GeneID" id="180348"/>
    <dbReference type="AGR" id="WB:WBGene00009759"/>
    <dbReference type="CTD" id="180348"/>
    <dbReference type="WormBase" id="F46B3.4b">
        <property type="protein sequence ID" value="CE45306"/>
        <property type="gene ID" value="WBGene00009759"/>
        <property type="gene designation" value="ttr-12"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121109_2_0_1"/>
    <dbReference type="OrthoDB" id="5827889at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009759">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6V6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF43">
        <property type="entry name" value="TRANSTHYRETIN-RELATED FAMILY DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBW48392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F46B3.4b"/>
        </source>
    </evidence>
    <sequence length="131" mass="15391" checksum="89D7C1E4231D2D45" modified="2010-11-02" version="1">MCRGRPYVGEMVQIWEPKIFDEMWSDQKTGVDGRFEMATNGNDVTLVDIPLLNFGFKPYLWINNFCGTEVMNGERCTKNLVKIPIPEWYVNPCRPDVHIFDIGVFEMDTVKGEDYNWFEKFLGYGKHCRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6V7</accession>
    <name>E1B6V7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T02G6.5</name>
        <name evidence="2 4" type="ORF">T02G6.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CBW48435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001251731.1">
        <property type="nucleotide sequence ID" value="NM_001264802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6V7"/>
    <dbReference type="GeneID" id="173060"/>
    <dbReference type="KEGG" id="cel:CELE_T02G6.5"/>
    <dbReference type="AGR" id="WB:WBGene00011388"/>
    <dbReference type="CTD" id="173060"/>
    <dbReference type="WormBase" id="T02G6.5b">
        <property type="protein sequence ID" value="CE45300"/>
        <property type="gene ID" value="WBGene00011388"/>
    </dbReference>
    <dbReference type="OMA" id="CHIEEDF"/>
    <dbReference type="OrthoDB" id="5778587at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011388">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6V7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012885">
        <property type="entry name" value="F-box_Sdz-33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21503:SF8">
        <property type="entry name" value="F-BOX ASSOCIATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21503">
        <property type="entry name" value="F-BOX-CONTAINING HYPOTHETICAL PROTEIN C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07735">
        <property type="entry name" value="FBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="108"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBW48435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T02G6.5b"/>
        </source>
    </evidence>
    <sequence length="449" mass="52972" checksum="6735CE04BC4062DA" modified="2010-11-02" version="1">MSSFRTAINFFSSSLTGYKGFKKLCKYILFSIFYTAFSNTFRQTMDVENLTMFMFIRLAMTYTPSLGVVSEEWDNNSILDEYLYILFRTLCHLQHKLWVKIFRLYKKPFNLHNLPYPAYRKIVLQMDICDMLQLSRTSSNTCLKTKKVNRKIYKLMISDPKLHDNNLITEDPLRQVYVIESKADLDFIYSSIKRVYGKNEGMFSSANFNYWIRTFCEHQKEQEKFRSIPYANSEELHHLLNFINQSVIVDELDLLIHHNSLFGDYKSILSHQMLDNCHDVEIFGPDFSLRNDEVNILLDRINLSGKLSIECMFSSSFNKEILFNIPQLEIWNALSFTLQDVMNMNCEVIILQHHILKSLDINRLIHYWLAGKMPNLRRIRVNANPDAKMLRGIVNYAWHPRRRPQVFRDGLEQLDCENGMDIVRSDGRIATLLDHNSFVDFLVWPHSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6V9</accession>
    <name>E1B6V9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T02G6.5</name>
        <name evidence="2 4" type="ORF">T02G6.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CBW48437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001251734.1">
        <property type="nucleotide sequence ID" value="NM_001264805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6V9"/>
    <dbReference type="GeneID" id="173060"/>
    <dbReference type="AGR" id="WB:WBGene00011388"/>
    <dbReference type="CTD" id="173060"/>
    <dbReference type="WormBase" id="T02G6.5d">
        <property type="protein sequence ID" value="CE45318"/>
        <property type="gene ID" value="WBGene00011388"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049370_1_0_1"/>
    <dbReference type="OrthoDB" id="5778587at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011388">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6V9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012885">
        <property type="entry name" value="F-box_Sdz-33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21503:SF8">
        <property type="entry name" value="F-BOX ASSOCIATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21503">
        <property type="entry name" value="F-BOX-CONTAINING HYPOTHETICAL PROTEIN C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07735">
        <property type="entry name" value="FBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sdz-33 F-box" evidence="1">
        <location>
            <begin position="192"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBW48437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T02G6.5d"/>
        </source>
    </evidence>
    <sequence length="324" mass="37973" checksum="7BFD3F4EF157049C" modified="2010-11-02" version="1">MDICDMLQLSRTSSNTCLKTKKVNRKIYKLMISDPKLHDNNLITEDPLRQVYVIESKADLDFIYSSIKRVYGKNEGMFSSANFNYWIRTFCEHQKEQEKFRSIPYANSEELHHLLNFINQSVIVDELDLLIHHNSLFGDYKSILSHQMLDNCHDVEIFGPDFSLRNDEVNILLDRINLSGKLSIECMFSSSFNKEILFNIPQLEIWNALSFTLQDVMNMNCEVIILQHHILKSLDINRLIHYWLAGKMPNLRRIRVNANPDAKMLRGIVNYAWHPRRRPQVFRDGLEQLDCENGMDIVRSDGRIATLLDHNSFVDFLVWPHSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6W0</accession>
    <name>E1B6W0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RSD-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rsd-2</name>
        <name evidence="4" type="ORF">CELE_F52G2.2</name>
        <name evidence="6" type="ORF">F52G2.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBW48393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255749.1">
        <property type="nucleotide sequence ID" value="NM_001268820.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6W0"/>
    <dbReference type="PeptideAtlas" id="E1B6W0"/>
    <dbReference type="GeneID" id="178322"/>
    <dbReference type="AGR" id="WB:WBGene00004681"/>
    <dbReference type="CTD" id="178322"/>
    <dbReference type="WormBase" id="F52G2.2d">
        <property type="protein sequence ID" value="CE45379"/>
        <property type="gene ID" value="WBGene00004681"/>
        <property type="gene designation" value="rsd-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006438_0_0_1"/>
    <dbReference type="OrthoDB" id="5879648at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004681">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6W0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040930">
        <property type="entry name" value="AF-9_AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011508">
        <property type="entry name" value="RSD-2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17793">
        <property type="entry name" value="AHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07547">
        <property type="entry name" value="RSD-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSD-2 N-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="AF-9 ANC1 homology" evidence="3">
        <location>
            <begin position="513"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBW48393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F52G2.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="E1B6W0"/>
        </source>
    </evidence>
    <sequence length="871" mass="98062" checksum="584903B87D371EC1" modified="2010-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLL6</accession>
    <name>H2FLL6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_T10C6.6</name>
        <name evidence="10 12" type="ORF">T10C6.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCF23428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLL6"/>
    <dbReference type="SMR" id="H2FLL6"/>
    <dbReference type="PeptideAtlas" id="H2FLL6"/>
    <dbReference type="AGR" id="WB:WBGene00011688"/>
    <dbReference type="WormBase" id="T10C6.6c">
        <property type="protein sequence ID" value="CE46848"/>
        <property type="gene ID" value="WBGene00011688"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_31_6_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011688">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLL6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17342">
        <property type="entry name" value="MFS_SLC37A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000132">
        <property type="entry name" value="sugar phosphate exchanger 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="8"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF23428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="T10C6.6c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="H2FLL6"/>
        </source>
    </evidence>
    <sequence length="452" mass="49042" checksum="1B5720C8AE88AB55" modified="2012-03-21" version="1">MSSRKVMVFVVTFVSYGLYHASRKALSGVKSSIKADWLSNSSGHAPLFTNEADAKHFLGSLDAIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVLPLGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANSSEPHHNFHGEPISLFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPALAGNTQAMSTVSGLLDGTGSAGSAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAILKRCIIDLKSLRKLRSGEESPLLNDEAGDHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLL8</accession>
    <name>H2FLL8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_T10C6.6</name>
        <name evidence="10 12" type="ORF">T10C6.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCF23430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLL8"/>
    <dbReference type="SMR" id="H2FLL8"/>
    <dbReference type="AGR" id="WB:WBGene00011688"/>
    <dbReference type="WormBase" id="T10C6.6d">
        <property type="protein sequence ID" value="CE46894"/>
        <property type="gene ID" value="WBGene00011688"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011688">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLL8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000132">
        <property type="entry name" value="sugar phosphate exchanger 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF23430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="T10C6.6d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="H2FLL8"/>
        </source>
    </evidence>
    <sequence length="396" mass="43119" checksum="56E88D8C3D18BFCC" modified="2012-03-21" version="1">MAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVLPLGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSSSSEPHHNFHGEPISLFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPALAGNTQAMSTVSGLLDGTGSAGSAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAILKRCIIDLKSLRKLRSGEESPLLNDEAGDHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLL9</accession>
    <name>H2FLL9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_T10C6.6</name>
        <name evidence="10 12" type="ORF">T10C6.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCF23431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLL9"/>
    <dbReference type="SMR" id="H2FLL9"/>
    <dbReference type="AGR" id="WB:WBGene00011688"/>
    <dbReference type="WormBase" id="T10C6.6e">
        <property type="protein sequence ID" value="CE46950"/>
        <property type="gene ID" value="WBGene00011688"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011688">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLL9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17342">
        <property type="entry name" value="MFS_SLC37A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000132">
        <property type="entry name" value="sugar phosphate exchanger 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="8"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF23431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="T10C6.6e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="H2FLL9"/>
        </source>
    </evidence>
    <sequence length="461" mass="50180" checksum="36F88A985AB8D476" modified="2012-03-21" version="1">MSSRKVMVFVVTFVSYGLYHASRKALSGVKSSIKADWLSNSSGHAPLFTNEADAKHFLGSLDAIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVLPLGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSSSSEPHHNFHGEPISLFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPALAGNTQAMSTVSGLLDGTGSAGSAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAILKRCIIDLKSLRKLRSGEESPLLNDEAGDHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLM1</accession>
    <name>H2FLM1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD repeat and FYVE domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">wdfy-3</name>
        <name evidence="14" type="ORF">C26H9A.2</name>
        <name evidence="12" type="ORF">CELE_C26H9A.2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCF23439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255659.1">
        <property type="nucleotide sequence ID" value="NM_001268730.3"/>
    </dbReference>
    <dbReference type="SMR" id="H2FLM1"/>
    <dbReference type="GeneID" id="178220"/>
    <dbReference type="AGR" id="WB:WBGene00007752"/>
    <dbReference type="CTD" id="178220"/>
    <dbReference type="WormBase" id="C26H9A.2d">
        <property type="protein sequence ID" value="CE46974"/>
        <property type="gene ID" value="WBGene00007752"/>
        <property type="gene designation" value="wdfy-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007752">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLM1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15719">
        <property type="entry name" value="FYVE_WDFY3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="11">
        <location>
            <begin position="2418"/>
            <end position="2545"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="10">
        <location>
            <begin position="2576"/>
            <end position="2869"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="3006"/>
            <end position="3047"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="3288"/>
            <end position="3348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2338"/>
            <end position="2411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3174"/>
            <end position="3212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2378"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2393"/>
            <end position="2407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3180"/>
            <end position="3212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF23439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="C26H9A.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="H2FLM1"/>
        </source>
    </evidence>
    <sequence length="3356" mass="374716" checksum="1E9AC1848F5B1592" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLM2</accession>
    <name>H2FLM2_CAEEL</name>
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        <submittedName>
            <fullName evidence="12">WD repeat and FYVE domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">wdfy-3</name>
        <name evidence="14" type="ORF">C26H9A.2</name>
        <name evidence="12" type="ORF">CELE_C26H9A.2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCF23440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255657.1">
        <property type="nucleotide sequence ID" value="NM_001268728.4"/>
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    <dbReference type="SMR" id="H2FLM2"/>
    <dbReference type="GeneID" id="178220"/>
    <dbReference type="AGR" id="WB:WBGene00007752"/>
    <dbReference type="CTD" id="178220"/>
    <dbReference type="WormBase" id="C26H9A.2b">
        <property type="protein sequence ID" value="CE46844"/>
        <property type="gene ID" value="WBGene00007752"/>
        <property type="gene designation" value="wdfy-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007752">
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
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    </dbReference>
    <dbReference type="CDD" id="cd15719">
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    </dbReference>
    <dbReference type="CDD" id="cd01201">
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    </dbReference>
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        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
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        <property type="entry name" value="Alfy-like_Arm-like"/>
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    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
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    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
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    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
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    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF23295">
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    <dbReference type="Pfam" id="PF01363">
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    <dbReference type="Pfam" id="PF14844">
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    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="11">
        <location>
            <begin position="2418"/>
            <end position="2545"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="10">
        <location>
            <begin position="2576"/>
            <end position="2869"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="3006"/>
            <end position="3047"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="3288"/>
            <end position="3348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2338"/>
            <end position="2411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3174"/>
            <end position="3212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2378"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2393"/>
            <end position="2407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3180"/>
            <end position="3212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF23440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="C26H9A.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="H2FLM2"/>
        </source>
    </evidence>
    <sequence length="3356" mass="374790" checksum="DBBA004C1B62CA93" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>K7STE9</accession>
    <name>K7STE9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calmodulin-binding domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">KCNL-2 variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">kcnl-2</name>
        <name evidence="12" type="ORF">CELE_F08A10.1</name>
        <name evidence="11 14" type="ORF">F08A10.1</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <title>KCNL-2, a Small Conductance Calcium-Activated K+ Channel, Plays a Role in the Regulation of the Rate of Egg-Laying in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chotoo C.K."/>
                <person name="Devor D.C."/>
                <person name="Luke C.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="JX455834">
        <property type="protein sequence ID" value="AFW03558.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293203.1">
        <property type="nucleotide sequence ID" value="NM_001306274.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K7STE9"/>
    <dbReference type="SMR" id="K7STE9"/>
    <dbReference type="GeneID" id="172602"/>
    <dbReference type="AGR" id="WB:WBGene00008570"/>
    <dbReference type="CTD" id="172602"/>
    <dbReference type="WormBase" id="F08A10.1i">
        <property type="protein sequence ID" value="CE49236"/>
        <property type="gene ID" value="WBGene00008570"/>
        <property type="gene designation" value="kcnl-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008570">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="K7STE9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000174">
        <property type="entry name" value="KCNN (Potassium K ChaNNel, calcium activated)-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000183">
        <property type="entry name" value="KCNN (Potassium K ChaNNel, calcium activated)-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004178">
        <property type="entry name" value="CaM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036122">
        <property type="entry name" value="CaM-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02888">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01053">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81327">
        <property type="entry name" value="Small-conductance potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin-binding" evidence="10">
        <location>
            <begin position="501"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFW03558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDK13434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F08A10.1i"/>
        </source>
    </evidence>
    <sequence length="652" mass="72832" checksum="19D1882BB898321F" modified="2013-02-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-22" modified="2026-01-28" version="163" xmlns="https://uniprot.org/uniprot">
    <accession>O17582-2</accession>
    <name>SPR4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Suppressor of presenilin protein 4</fullName>
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    </protein>
    <gene>
        <name type="primary">spr-4</name>
        <name type="ORF">C09H6.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Development" volume="130" first="2117" last="2128">
            <title>Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lakowski B."/>
                <person name="Eimer S."/>
                <person name="Goebel C."/>
                <person name="Boettcher A."/>
                <person name="Wagler B."/>
                <person name="Baumeister R."/>
            </authorList>
            <dbReference type="PubMed" id="12668626"/>
            <dbReference type="DOI" id="10.1242/dev.00429"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="Nature" volume="507" first="448" last="454">
            <title>REST and stress resistance in ageing and Alzheimer's disease.</title>
            <authorList>
                <person name="Lu T."/>
                <person name="Aron L."/>
                <person name="Zullo J."/>
                <person name="Pan Y."/>
                <person name="Kim H."/>
                <person name="Chen Y."/>
                <person name="Yang T.H."/>
                <person name="Kim H.M."/>
                <person name="Drake D."/>
                <person name="Liu X.S."/>
                <person name="Bennett D.A."/>
                <person name="Colaiacovo M.P."/>
                <person name="Yankner B.A."/>
            </authorList>
            <dbReference type="PubMed" id="24670762"/>
            <dbReference type="DOI" id="10.1038/nature13163"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INDUCTION BY OXIDATIVE STRESS</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 683-TRP--VAL-1311</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O17582-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O17582-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_008060"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001020994.1">
        <property type="nucleotide sequence ID" value="NM_001025823.6"/>
    </dbReference>
    <dbReference type="WormBase" id="C09H6.1b">
        <property type="protein sequence ID" value="CE15609"/>
        <property type="gene ID" value="WBGene00005009"/>
        <property type="gene designation" value="spr-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="1309" mass="149913" checksum="1730EA4BA8895554" modified="2002-06-01" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="160" xmlns="https://uniprot.org/uniprot">
    <accession>P54816-2</accession>
    <name>TBP7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Tat-binding homolog 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Lin-48 expression abnormal protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">lex-1</name>
        <name type="ORF">F11A10.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="278" first="507" last="518">
            <title>The bromodomain protein LEX-1 acts with TAM-1 to modulate gene expression in C. elegans.</title>
            <authorList>
                <person name="Tseng R.-J."/>
                <person name="Armstrong K.R."/>
                <person name="Wang X."/>
                <person name="Chamberlin H.M."/>
            </authorList>
            <dbReference type="PubMed" id="17618463"/>
            <dbReference type="DOI" id="10.1007/s00438-007-0265-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ALA-548 AND GLY-1001</scope>
        <source>
            <strain>CM3</strain>
            <tissue>Embryo</tissue>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P54816-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_032726"/>
        </isoform>
        <isoform>
            <id>P54816-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P54816-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_032725"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001122768.1">
        <property type="nucleotide sequence ID" value="NM_001129296.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F11A10.1b">
        <property type="protein sequence ID" value="CE41384"/>
        <property type="gene ID" value="WBGene00008682"/>
        <property type="gene designation" value="lex-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="1289" mass="146235" checksum="86481F6F49C05C0F" modified="2007-07-10" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="160" xmlns="https://uniprot.org/uniprot">
    <accession>P54816-3</accession>
    <name>TBP7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Tat-binding homolog 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Lin-48 expression abnormal protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">lex-1</name>
        <name type="ORF">F11A10.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Mol. Genet. Genomics" volume="278" first="507" last="518">
            <title>The bromodomain protein LEX-1 acts with TAM-1 to modulate gene expression in C. elegans.</title>
            <authorList>
                <person name="Tseng R.-J."/>
                <person name="Armstrong K.R."/>
                <person name="Wang X."/>
                <person name="Chamberlin H.M."/>
            </authorList>
            <dbReference type="PubMed" id="17618463"/>
            <dbReference type="DOI" id="10.1007/s00438-007-0265-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ALA-548 AND GLY-1001</scope>
        <source>
            <strain>CM3</strain>
            <tissue>Embryo</tissue>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P54816-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_032726"/>
        </isoform>
        <isoform>
            <id>P54816-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_032725"/>
        </isoform>
        <isoform>
            <id>P54816-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="1242" mass="140520" checksum="9E53832C2B330A7F" modified="2007-07-10" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="169" xmlns="https://uniprot.org/uniprot">
    <accession>P90794-2</accession>
    <name>DCA11_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of DDB1- and CUL4-associated factor 11 homolog</fullName>
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        <alternativeName>
            <fullName>WD repeat-containing protein 23</fullName>
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    <gene>
        <name evidence="1" type="primary">wdr-23</name>
        <name evidence="1" type="ORF">D2030.9</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="PLoS Genet." volume="3" first="E56" last="E56">
            <title>Lifespan regulation by evolutionarily conserved genes essential for viability.</title>
            <authorList>
                <person name="Curran S.P."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="17411345"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.0030056"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="NeuroToxicology" volume="38" first="51" last="60">
            <title>The Nrf2/SKN-1-dependent glutathione S-transferase pi homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism.</title>
            <authorList>
                <person name="Settivari R."/>
                <person name="VanDuyn N."/>
                <person name="LeVora J."/>
                <person name="Nass R."/>
            </authorList>
            <dbReference type="PubMed" id="23721876"/>
            <dbReference type="DOI" id="10.1016/j.neuro.2013.05.014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2019" name="J. Biol. Chem." volume="294" first="9536" last="9554">
            <title>Tyrosine aminotransferase is involved in the oxidative stress response by metabolizing meta-tyrosine in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ipson B.R."/>
                <person name="Green R.A."/>
                <person name="Wilson J.T."/>
                <person name="Watson J.N."/>
                <person name="Faull K.F."/>
                <person name="Fisher A.L."/>
            </authorList>
            <dbReference type="PubMed" id="31043480"/>
            <dbReference type="DOI" id="10.1074/jbc.ra118.004426"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P90794-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_036073 VSP_036072"/>
        </isoform>
        <isoform>
            <id>P90794-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_492125.1">
        <property type="nucleotide sequence ID" value="NM_059724.4"/>
    </dbReference>
    <dbReference type="WormBase" id="D2030.9b">
        <property type="protein sequence ID" value="CE23620"/>
        <property type="gene ID" value="WBGene00008419"/>
        <property type="gene designation" value="wdr-23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="D2030.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="D2030.9b"/>
        </source>
    </evidence>
    <sequence length="530" mass="60311" checksum="797833C17382D84C" modified="1997-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="180" xmlns="https://uniprot.org/uniprot">
    <accession>Q17353-3</accession>
    <name>PAR3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Partitioning defective protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Abnormal embryonic partitioning of cytoplasm protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">par-3</name>
        <name type="ORF">F54E7.3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1995" name="Cell" volume="83" first="743" last="752">
            <title>Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos.</title>
            <authorList>
                <person name="Etemad-Moghadam B."/>
                <person name="Guo S."/>
                <person name="Kemphues K.J."/>
            </authorList>
            <dbReference type="PubMed" id="8521491"/>
            <dbReference type="DOI" id="10.1016/0092-8674(95)90187-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain evidence="1">Bristol N2</strain>
            <tissue evidence="1">Embryo</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="1996" name="Development" volume="122" first="3133" last="3140">
            <title>par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.</title>
            <authorList>
                <person name="Watts J.L."/>
                <person name="Etemad-Moghadam B."/>
                <person name="Guo S."/>
                <person name="Boyd L."/>
                <person name="Draper B.W."/>
                <person name="Mello C.C."/>
                <person name="Priess J.R."/>
                <person name="Kemphues K.J."/>
            </authorList>
            <dbReference type="PubMed" id="8898226"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PAR-6</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="1998" name="Development" volume="125" first="3607" last="3614">
            <title>Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tabuse Y."/>
                <person name="Izumi Y."/>
                <person name="Piano F."/>
                <person name="Kemphues K.J."/>
                <person name="Miwa J."/>
                <person name="Ohno S."/>
            </authorList>
            <dbReference type="PubMed" id="9716526"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PKC-3</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="1999" name="Development" volume="126" first="127" last="135">
            <title>PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos.</title>
            <authorList>
                <person name="Hung T.-J."/>
                <person name="Kemphues K.J."/>
            </authorList>
            <dbReference type="PubMed" id="9834192"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PAR-6 AND PKC-3</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="journal article" date="2003" name="Development" volume="130" first="5339" last="5350">
            <title>C. elegans PAR-3 and PAR-6 are required for apicobasal asymmetries associated with cell adhesion and gastrulation.</title>
            <authorList>
                <person name="Nance J."/>
                <person name="Munro E.M."/>
                <person name="Priess J.R."/>
            </authorList>
            <dbReference type="PubMed" id="13129846"/>
            <dbReference type="DOI" id="10.1242/dev.00735"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2003" name="Development" volume="130" first="5717" last="5730">
            <title>LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.</title>
            <authorList>
                <person name="Tsou M.-F.B."/>
                <person name="Hayashi A."/>
                <person name="Rose L.S."/>
            </authorList>
            <dbReference type="PubMed" id="14534135"/>
            <dbReference type="DOI" id="10.1242/dev.00790"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2004" name="Development" volume="131" first="2865" last="2874">
            <title>PAR-3 is required for epithelial cell polarity in the distal spermatheca of C. elegans.</title>
            <authorList>
                <person name="Aono S."/>
                <person name="Legouis R."/>
                <person name="Hoose W.A."/>
                <person name="Kemphues K.J."/>
            </authorList>
            <dbReference type="PubMed" id="15151982"/>
            <dbReference type="DOI" id="10.1242/dev.01146"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2008" name="Dev. Cell" volume="15" first="198" last="208">
            <title>A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning.</title>
            <authorList>
                <person name="Panbianco C."/>
                <person name="Weinkove D."/>
                <person name="Zanin E."/>
                <person name="Jones D."/>
                <person name="Divecha N."/>
                <person name="Gotta M."/>
                <person name="Ahringer J."/>
            </authorList>
            <dbReference type="PubMed" id="18694560"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2008.06.002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-1812329">
            <id>Q17353-3</id>
        </interactant>
        <interactant intactId="EBI-2413872">
            <id>H2L055</id>
            <label>CELE_F53A10.2</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1812329">
            <id>Q17353-3</id>
        </interactant>
        <interactant intactId="EBI-320525">
            <id>Q22387</id>
            <label>CELE_T11B7.1</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1812329">
            <id>Q17353-3</id>
        </interactant>
        <interactant intactId="EBI-328492">
            <id>O16502</id>
            <label>abu-7</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q17353-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_034689 VSP_051597"/>
        </isoform>
        <isoform>
            <id>Q17353-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_051597"/>
        </isoform>
        <isoform>
            <id>Q17353-1</id>
            <name evidence="1">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379568.1">
        <property type="nucleotide sequence ID" value="NM_001392104.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F54E7.3c">
        <property type="protein sequence ID" value="CE39941"/>
        <property type="gene ID" value="WBGene00003918"/>
        <property type="gene designation" value="par-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="8521491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="8898226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="9834192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="AAB18670.1"/>
        </source>
    </evidence>
    <sequence length="1340" mass="145588" checksum="390E4FBB0E9236E0" modified="1996-11-01" version="1"> </sequence>
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<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q19238-2</accession>
    <name>YS3J_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Putative tyrosine-protein kinase F09A5.2</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">F09A5.2</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19238-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q19238-2</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_060802"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001359563.1">
        <property type="nucleotide sequence ID" value="NM_001373547.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F09A5.2a">
        <property type="protein sequence ID" value="CE53176"/>
        <property type="gene ID" value="WBGene00008599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F09A5.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F09A5.2b"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q2EEP3</accession>
    <name>Q2EEP3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-mRNA cleavage complex subunit Clp1 C-terminal domain-containing protein</fullName>
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    <gene>
        <name evidence="7 9" type="primary">clpf-1</name>
        <name evidence="7" type="ORF">CELE_F59A2.4</name>
        <name evidence="9" type="ORF">F59A2.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
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    <comment type="subcellular location">
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        <property type="protein sequence ID" value="CAJ76938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001047394.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2EEP3"/>
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    <dbReference type="PeptideAtlas" id="Q2EEP3"/>
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        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010304"/>
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    <dbReference type="WormBase" id="F59A2.4b">
        <property type="protein sequence ID" value="CE39740"/>
        <property type="gene ID" value="WBGene00010304"/>
        <property type="gene designation" value="clpf-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018195_1_0_1"/>
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        <property type="component" value="Chromosome III"/>
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.330:FF:000002">
        <property type="entry name" value="Protein CLP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
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        <property type="entry name" value="Clp1_C"/>
    </dbReference>
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        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
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        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
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    </dbReference>
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        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
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    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 C-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ76938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F59A2.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q2EEP3"/>
        </source>
    </evidence>
    <sequence length="85" mass="9755" checksum="09AA963DCD3ACE25" modified="2006-03-21" version="1">MEVENHETKLVIMEPSADIKHHLFAFSRSTKADENVLKSPVFGFCLVTEVDLEKRTMSILCPQRTIPSKVLVFSDITHLDDQIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-08-16" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6BEU8</accession>
    <name>Q6BEU8_CAEEL</name>
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        <submittedName>
            <fullName evidence="6">Acetyl-coenzyme A transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_T26C5.3</name>
        <name evidence="6 8" type="ORF">T26C5.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAH04735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022370.1">
        <property type="nucleotide sequence ID" value="NM_001027199.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6BEU8"/>
    <dbReference type="SMR" id="Q6BEU8"/>
    <dbReference type="GeneID" id="259455"/>
    <dbReference type="KEGG" id="cel:CELE_T26C5.3"/>
    <dbReference type="UCSC" id="T26C5.3c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012033"/>
    <dbReference type="CTD" id="259455"/>
    <dbReference type="WormBase" id="T26C5.3c">
        <property type="protein sequence ID" value="CE36955"/>
        <property type="gene ID" value="WBGene00012033"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012033">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6BEU8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000814">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH04735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="T26C5.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q6BEU8"/>
        </source>
    </evidence>
    <sequence length="574" mass="64139" checksum="AF4261A7FB28CFE1" modified="2004-08-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-08-16" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6BEV6</accession>
    <name>Q6BEV6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleolar protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F49E2.5</name>
        <name evidence="2 4" type="ORF">F49E2.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAH04746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6BEV6"/>
    <dbReference type="SMR" id="Q6BEV6"/>
    <dbReference type="PeptideAtlas" id="Q6BEV6"/>
    <dbReference type="UCSC" id="F49E2.5j.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009888"/>
    <dbReference type="WormBase" id="F49E2.5h">
        <property type="protein sequence ID" value="CE36488"/>
        <property type="gene ID" value="WBGene00009888"/>
    </dbReference>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009888">
        <property type="expression patterns" value="Expressed in larva and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6BEV6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006836">
        <property type="entry name" value="DUF612"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31765">
        <property type="entry name" value="PROTEIN CBG12783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31765:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04747">
        <property type="entry name" value="DUF612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH04746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F49E2.5h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q6BEV6"/>
        </source>
    </evidence>
    <sequence length="845" mass="93284" checksum="77E633921AF8DA17" modified="2004-08-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-08-16" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6BEV8</accession>
    <name>Q6BEV8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
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                <person name="Fuke S."/>
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            <dbReference type="DOI" id="10.1371/journal.pone.0115985"/>
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            <authorList>
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            <authorList>
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                <person name="Zhang L."/>
                <person name="Liu Y."/>
                <person name="Topalidou I."/>
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                <person name="Ailion M."/>
                <person name="Zhao Z."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2004" name="Nat. Neurosci." volume="7" first="1096" last="1103">
            <title>Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans.</title>
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            <title>Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to invertebrates from Caenorhabditis elegans.</title>
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                <person name="Fuke S."/>
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                <person name="Sasagawa N."/>
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        <citation type="journal article" date="2009" name="EMBO J." volume="28" first="2437" last="2448">
            <title>Dopamine counteracts octopamine signalling in a neural circuit mediating food response in C. elegans.</title>
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                <person name="Topalidou I."/>
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            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_052257 VSP_052258"/>
        </isoform>
        <isoform>
            <id>Q6RYS9-1</id>
            <name evidence="4">b</name>
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        <isoform>
            <id>Q6RYS9-4</id>
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            <name evidence="1">DOP-3nf</name>
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        </isoform>
        <isoform>
            <id>Q6RYS9-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_052258"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001368078.1">
        <property type="nucleotide sequence ID" value="NM_001381012.1"/>
    </dbReference>
    <dbReference type="WormBase" id="T14E8.3c">
        <property type="protein sequence ID" value="CE39180"/>
        <property type="gene ID" value="WBGene00020506"/>
        <property type="gene designation" value="dop-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="16001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T14E8.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T14E8.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T14E8.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T14E8.3d"/>
        </source>
    </evidence>
    <sequence length="590" mass="66550" checksum="78861D438343F38D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q6RYS9-4</accession>
    <name>DOPR3_CAEEL</name>
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        <recommendedName>
            <fullName evidence="4">Isoform d of Dopamine receptor 3</fullName>
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        <alternativeName>
            <fullName evidence="2">Dopamine D2-like receptor dop-3</fullName>
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    <gene>
        <name evidence="4" type="primary">dop-3</name>
        <name evidence="4" type="ORF">T14E8.3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nat. Neurosci." volume="7" first="1096" last="1103">
            <title>Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chase D.L."/>
                <person name="Pepper J.S."/>
                <person name="Koelle M.R."/>
            </authorList>
            <dbReference type="PubMed" id="15378064"/>
            <dbReference type="DOI" id="10.1038/nn1316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2005" name="J. Neurochem." volume="94" first="1146" last="1157">
            <title>Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to invertebrates from Caenorhabditis elegans.</title>
            <authorList>
                <person name="Sugiura M."/>
                <person name="Fuke S."/>
                <person name="Suo S."/>
                <person name="Sasagawa N."/>
                <person name="Van Tol H.H.M."/>
                <person name="Ishiura S."/>
            </authorList>
            <dbReference type="PubMed" id="16001968"/>
            <dbReference type="DOI" id="10.1111/j.1471-4159.2005.03268.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS C AND D)</scope>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ASP-102 AND SER-184</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="EMBO J." volume="28" first="2437" last="2448">
            <title>Dopamine counteracts octopamine signalling in a neural circuit mediating food response in C. elegans.</title>
            <authorList>
                <person name="Suo S."/>
                <person name="Culotti J.G."/>
                <person name="Van Tol H.H."/>
            </authorList>
            <dbReference type="PubMed" id="19609300"/>
            <dbReference type="DOI" id="10.1038/emboj.2009.194"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003015" last="E1003015">
            <title>C. elegans dopaminergic D2-like receptors delimit recurrent cholinergic-mediated motor programs during a goal-oriented behavior.</title>
            <authorList>
                <person name="Correa P."/>
                <person name="LeBoeuf B."/>
                <person name="Garcia L.R."/>
            </authorList>
            <dbReference type="PubMed" id="23166505"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E115985" last="E115985">
            <title>Dopamine receptors antagonistically regulate behavioral choice between conflicting alternatives in C. elegans.</title>
            <authorList>
                <person name="Wang D."/>
                <person name="Yu Y."/>
                <person name="Li Y."/>
                <person name="Wang Y."/>
                <person name="Wang D."/>
            </authorList>
            <dbReference type="PubMed" id="25536037"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0115985"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="7">
        <citation type="journal article" date="2017" name="PLoS Genet." volume="13" first="E1007032" last="E1007032">
            <title>Dopamine negatively modulates the NCA ion channels in C. elegans.</title>
            <authorList>
                <person name="Topalidou I."/>
                <person name="Cooper K."/>
                <person name="Pereira L."/>
                <person name="Ailion M."/>
            </authorList>
            <dbReference type="PubMed" id="28968387"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1007032"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="8">
        <citation type="journal article" date="2021" name="IScience" volume="24" first="102247" last="102247">
            <title>Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans.</title>
            <authorList>
                <person name="Xu Y."/>
                <person name="Zhang L."/>
                <person name="Liu Y."/>
                <person name="Topalidou I."/>
                <person name="Hassinan C."/>
                <person name="Ailion M."/>
                <person name="Zhao Z."/>
                <person name="Wang T."/>
                <person name="Chen Z."/>
                <person name="Bai J."/>
            </authorList>
            <dbReference type="PubMed" id="33796839"/>
            <dbReference type="DOI" id="10.1016/j.isci.2021.102247"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="9">
        <citation type="journal article" date="2022" name="Neurosci. Res." volume="178" first="87" last="92">
            <title>A role for dopamine in C. elegans avoidance behavior induced by mitochondrial stress.</title>
            <authorList>
                <person name="Chou S.H."/>
                <person name="Chen Y.J."/>
                <person name="Liao C.P."/>
                <person name="Pan C.L."/>
            </authorList>
            <dbReference type="PubMed" id="35074444"/>
            <dbReference type="DOI" id="10.1016/j.neures.2022.01.005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q6RYS9-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q6RYS9-4</id>
            <name evidence="6">d</name>
            <name evidence="1">DOP-3nf</name>
            <sequence type="described" ref="VSP_052260 VSP_052257 VSP_052259"/>
        </isoform>
        <isoform>
            <id>Q6RYS9-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_052258"/>
        </isoform>
        <isoform>
            <id>Q6RYS9-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_052258 VSP_052257"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001033561.1">
        <property type="nucleotide sequence ID" value="NM_001038472.6"/>
    </dbReference>
    <dbReference type="WormBase" id="T14E8.3d">
        <property type="protein sequence ID" value="CE39181"/>
        <property type="gene ID" value="WBGene00020506"/>
        <property type="gene designation" value="dop-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="16001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T14E8.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T14E8.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T14E8.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T14E8.3d"/>
        </source>
    </evidence>
    <sequence length="245" mass="27446" checksum="EF5F487AC8446088" modified="2004-07-05" version="1">MVVLWRVAAGVFLPLVPTMAVFGNVLVIMSVFRERSLQTVTNMLIVSLAVSDFMVAIGVMSFGVYYEWNDFKWGLGSFFCHVYQALDVACSTASILNLLAISLDRYIAIGHPISYAQYGARGGRAMISITIVWGVSVAVALPLLLGVNPMEENDLQECELANPYFNMISSIFSFFIPCIAMIILYTIIFRRLRQRERARSLRQAQRSENDKISSALLGGAQIARQMGKHFKNRTDQILLEISFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>Q86G95</accession>
    <name>Q86G95_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">drap-1</name>
        <name evidence="5" type="ORF">CELE_F40F9.7</name>
        <name evidence="7" type="ORF">F40F9.7</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAD82914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379388.1">
        <property type="nucleotide sequence ID" value="NM_001392584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86G95"/>
    <dbReference type="SMR" id="Q86G95"/>
    <dbReference type="GeneID" id="179365"/>
    <dbReference type="UCSC" id="F40F9.7b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009584"/>
    <dbReference type="CTD" id="179365"/>
    <dbReference type="WormBase" id="F40F9.7b">
        <property type="protein sequence ID" value="CE33580"/>
        <property type="gene ID" value="WBGene00009584"/>
        <property type="gene designation" value="drap-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_855893_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009584">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86G95">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
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    </dbReference>
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        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR10252">
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    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="305"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD82914.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F40F9.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q86G95"/>
        </source>
    </evidence>
    <sequence length="305" mass="33462" checksum="1791D4DEF2935646" modified="2003-06-01" version="1">MSTLASTSSAGASSSTGSSNQQQQQAAAVIRRRRFSTAKIQPTRIKKVMQSDEDIGRMVQSVPVSIGRAMEHFAEKFLQAAAEATQFTSSKTLNPQHMKQAVLNTPHFSFLESVFKDVALPQQASELNTARTGMTLRGQQMLQEQQNSDFASAILANAQMQMMQMDQQALKQEDGTISPYLVDPQSPAAPLPLYLQGIPSNYPVVQELTATVPLSPSTPTTQLVNGMLGMLKYSKKDSEGQRLTGLKRASTDGDGEDRPKRGRPKKLKPEKCIDDDLYEEASRNIAKEDKDRELMPPPALPIGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-02-01" modified="2026-01-28" version="187" xmlns="https://uniprot.org/uniprot">
    <accession>Q93849</accession>
    <name>Q93849_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">IRK_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">irk-3</name>
        <name evidence="15" type="ORF">CELE_K04G11.5</name>
        <name evidence="17" type="ORF">K04G11.5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAB01762.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T23319">
        <property type="entry name" value="T23319"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379171.1">
        <property type="nucleotide sequence ID" value="NM_001392886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q93849"/>
    <dbReference type="SMR" id="Q93849"/>
    <dbReference type="PaxDb" id="6239-K04G11.5"/>
    <dbReference type="GeneID" id="191696"/>
    <dbReference type="AGR" id="WB:WBGene00002151"/>
    <dbReference type="CTD" id="191696"/>
    <dbReference type="WormBase" id="K04G11.5a">
        <property type="protein sequence ID" value="CE35580"/>
        <property type="gene ID" value="WBGene00002151"/>
        <property type="gene designation" value="irk-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022738_3_0_1"/>
    <dbReference type="OMA" id="VRLYMAC"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="PhylomeDB" id="Q93849"/>
    <dbReference type="PRO" id="PR:Q93849"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002151">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q93849">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007614">
        <property type="term" value="P:short-term memory"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000247">
        <property type="entry name" value="Inward Rectifying K (Potassium) channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000007">
        <property type="entry name" value="Inward Rectifying K (Potassium) channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF61">
        <property type="entry name" value="IRK_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="13">
        <location>
            <begin position="40"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="14">
        <location>
            <begin position="186"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAB01762.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="K04G11.5a"/>
        </source>
    </evidence>
    <sequence length="374" mass="43332" checksum="DA1EC0284001122A" modified="2004-07-05" version="3">MSLAEELERLSGENGAKKELNGWRLSSSAPELGVQRARLVSKDGKTLLNNIQIPERFRQAYKWRYCRNWFHLIIECNWRTICILFLLGFIVSWTIFAVIYYVISRLKTVKKDESCIANVDTLISAFLFSMESQHTIGYGLRYMTDLCPPAYLTLCVQCVVGVFLQTILAGIVIAKILRPKKRRQEMRFSRMAVIGPLDEHDKRPTLMIRLADIQEKLFLAESHVRLYMACSKINSRGDRELIGVKDMNVGYDSGWDRVLLLWPIIVRHVINEDSPLYGMSRENIVKADFELIMTVEGIVEATGMTFQARTSFLPDEILWGYKFKPMVLMNEKLSKYEVHYSFFDQTERVCDFDAQTIETEETEDEHHHNASGFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-28" modified="2026-01-28" version="181" xmlns="https://uniprot.org/uniprot">
    <accession>Q9BMN8-2</accession>
    <name>LAR_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Tyrosine-protein phosphatase Lar-like</fullName>
            <ecNumber>3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Protein-tyrosine phosphate 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ptp-3</name>
        <name type="ORF">C09D8.1/C09D8.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2002" name="Development" volume="129" first="2141" last="2153">
            <title>The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis.</title>
            <authorList>
                <person name="Harrington R.J."/>
                <person name="Gutch M.J."/>
                <person name="Hengartner M.O."/>
                <person name="Tonks N.K."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="11959824"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-574 AND ASN-1212</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9BMN8-1</id>
            <name evidence="1">a</name>
            <name>ptp-3a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9BMN8-2</id>
            <name evidence="1">b</name>
            <name>ptp-3b</name>
            <sequence type="described" ref="VSP_007008 VSP_007007"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="11959824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1487" mass="167959" checksum="2FBE21B52B16F7D7" modified="2001-06-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TYL8</accession>
    <name>Q9TYL8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">srg-21</name>
        <name evidence="7" type="ORF">CELE_Y25C1A.9</name>
        <name evidence="9" type="ORF">Y25C1A.9</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T33908">
        <property type="entry name" value="T33908"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_494442.2">
        <property type="nucleotide sequence ID" value="NM_062041.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9TYL8"/>
    <dbReference type="PaxDb" id="6239-Y25C1A.9"/>
    <dbReference type="GeneID" id="189538"/>
    <dbReference type="UCSC" id="Y25C1A.9">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00005178"/>
    <dbReference type="CTD" id="189538"/>
    <dbReference type="WormBase" id="Y25C1A.9a">
        <property type="protein sequence ID" value="CE33211"/>
        <property type="gene ID" value="WBGene00005178"/>
        <property type="gene designation" value="srg-21"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TGR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061253_1_0_1"/>
    <dbReference type="OrthoDB" id="5808804at2759"/>
    <dbReference type="PhylomeDB" id="Q9TYL8"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627:SF3">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00698">
        <property type="entry name" value="TMPROTEINSRG"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD61988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y25C1A.9a"/>
        </source>
    </evidence>
    <sequence length="317" mass="36674" checksum="C03CB1C43F731A01" modified="2003-06-01" version="2">MSFTLPANFSYSDPLPFTCNEDPSVKLSILYYLIQASYLVLSAILNVLILNTIFKSKNKEHYRNNSFYILYTTEAVVNIYTSCVAVFFSRLFSDVTPLCPLVAPYFFTPSIITKAYYTINHYMLAFKTLSQIAVSFNRMTCVILPVRHVHLWKRILWPMVIAQFVLPLGVIWNILLSRVYINPNGAGFSVNYKDAIPWANISFLHLFHCIPCVVLVTIFFIVTIYGLTILEYRIKNVERYLTIFTLIMGIQTALFAFTQIYFAFFTAYLPGIRSFMLFSAFHIFDLLHVYSPIALIIMHRQLRNDIFGLKQENGNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XTU2</accession>
    <name>Q9XTU2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y49E10.21</name>
        <name evidence="2 4" type="ORF">Y49E10.21</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAB11555.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T27045">
        <property type="entry name" value="T27045"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255173.1">
        <property type="nucleotide sequence ID" value="NM_001268244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XTU2"/>
    <dbReference type="SMR" id="Q9XTU2"/>
    <dbReference type="PeptideAtlas" id="Q9XTU2"/>
    <dbReference type="GeneID" id="190069"/>
    <dbReference type="KEGG" id="cel:CELE_Y49E10.21"/>
    <dbReference type="UCSC" id="Y49E10.21">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013040"/>
    <dbReference type="CTD" id="190069"/>
    <dbReference type="WormBase" id="Y49E10.21b">
        <property type="protein sequence ID" value="CE28707"/>
        <property type="gene ID" value="WBGene00013040"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_714198_0_0_1"/>
    <dbReference type="OrthoDB" id="5855233at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013040">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XTU2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB11555.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y49E10.21b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XTU2"/>
        </source>
    </evidence>
    <sequence length="387" mass="44884" checksum="D925A6C6C304A961" modified="2001-12-01" version="2">MQALQERLEKLENATGSEVWEVLKASEPELRQDLSSLQKLKADKESAAREALTALKTKKNELKNLKNDVESLKNEYKTYIEMVENGLKQSGLDIKQVVQVFERVLEESLSEKRLAILSTIDSAHISDIKSIKTPVKSILKLLEDPNKLQLRILVQSELREFSNSAIEIFRRSLWDLFQNQGIPMKNLGEMPNSEDFLQKIGELFQFSTDLDKLIAGNWGKSIENLISAAFGQLSNYCIDIIENERGEADFEWILKSSHDWAKNLSQILQKTVEKSNLESELKQEFEEKFNEKFVDFIKLITRKFLEKNIKEPTIFSNVAQMLKKFKISSEFNLSGDRDLQEPFYEPKFMSRWILVYYIVAKISEYPVLTQLFAPLKITVVSKKIFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XTW6</accession>
    <name>Q9XTW6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_H12D21.9</name>
        <name evidence="3 5" type="ORF">H12D21.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB07432.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_506676.2">
        <property type="nucleotide sequence ID" value="NM_074275.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XTW6"/>
    <dbReference type="SMR" id="Q9XTW6"/>
    <dbReference type="PaxDb" id="6239-H12D21.9"/>
    <dbReference type="GeneID" id="186731"/>
    <dbReference type="UCSC" id="H12D21.9">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010385"/>
    <dbReference type="CTD" id="186731"/>
    <dbReference type="WormBase" id="H12D21.9a">
        <property type="protein sequence ID" value="CE42940"/>
        <property type="gene ID" value="WBGene00010385"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S12U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083714_0_0_1"/>
    <dbReference type="OMA" id="VYYRDTY"/>
    <dbReference type="OrthoDB" id="5917100at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010385">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XTW6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB07432.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="H12D21.9a"/>
        </source>
    </evidence>
    <sequence length="290" mass="32362" checksum="334E8F3B07F63F07" modified="2008-09-23" version="2">MPNFPPNVYYRDTYGFDDRPSESDNDSITTKSTVTVRTTYNINPGGGNGGMAINPTYQHIHNRNMNTGGDPSKMVNYSHVSNSFHVEQLVTSKILTPNPRTILICVLIAAASAIQLLIFSMIAVFYDGPFPWSLILCILMLCNCLVVFIFIRCQPTRGWLISSLIAAALSFIECTALFFWTALLISQEEKYLESVGIHDNRIVTSTRIAMYMCQMLFGPIHLIACGLIIWKLRTQLSPSDEVVNGYFLSEPELGHQKILVPIELRQIRDQSDDETSNASIGVQTGGSRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XTW9</accession>
    <name>Q9XTW9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="1">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mpst-3</name>
        <name evidence="6" type="ORF">CELE_H12D21.7</name>
        <name evidence="8" type="ORF">H12D21.7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="1"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB07429.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T23075">
        <property type="entry name" value="T23075"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256632.1">
        <property type="nucleotide sequence ID" value="NM_001269703.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XTW9"/>
    <dbReference type="SMR" id="Q9XTW9"/>
    <dbReference type="PeptideAtlas" id="Q9XTW9"/>
    <dbReference type="GeneID" id="3565829"/>
    <dbReference type="UCSC" id="H12D21.7.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010383"/>
    <dbReference type="CTD" id="3565829"/>
    <dbReference type="WormBase" id="H12D21.7a">
        <property type="protein sequence ID" value="CE36178"/>
        <property type="gene ID" value="WBGene00010383"/>
        <property type="gene designation" value="mpst-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076711_0_0_1"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="PhylomeDB" id="Q9XTW9"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010383">
        <property type="expression patterns" value="Expressed in material anatomical entity and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XTW9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000058">
        <property type="entry name" value="MercaptoPyruvate SulfurTransferase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000066">
        <property type="entry name" value="MercaptoPyruvate SulfurTransferase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="15"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="185"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB07429.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="H12D21.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XTW9"/>
        </source>
    </evidence>
    <sequence length="306" mass="33416" checksum="704F73F3250CB21A" modified="2004-07-05" version="2">MSTNPIVTPQWLMQNVNKVRLIDATYAPTATRDYKEFKTKCYGNFDLLTKNNTVAAYTGEHIPGAAHFGLDSAYFPSQYIKFDLYPPEHFEKYLRLLGINNDEQVVIYSRGPAAGMMFASRAYWTLKAYGLTNLSLLNGGLDAWKAAGGPTDNSVVTPKLGNVNVKSLDNTILAKFEEIPFNEFAENKVDYLDARTTPQFTGEEPLNKTFPDTKATGSHVTGAISFPMAKVIGPDGFISQQDVDAQIANLGLKSGNQVYVACNTGIQASVIFVALERSGIKAKLYNGSMTELASRAPELVNATGNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-03-15" modified="2026-01-28" version="181" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXH8-2</accession>
    <name>CNT1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Arf-GAP with ANK repeat and PH domain-containing protein cnt-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">CED-3 protease suppressor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Centaurin 1</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">Truncated cnt-1</fullName>
                <shortName evidence="1">tCNT-1</shortName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="primary">cnt-1</name>
        <name evidence="1" type="synonym">cps-2</name>
        <name evidence="5" type="ORF">Y17G7B.15</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="1999-02" db="EMBL/GenBank/DDBJ databases">
            <title>Investigating the functions of the centaurin proteins in phosphoinositide signalling in C. elegans.</title>
            <authorList>
                <person name="Harrington L.S."/>
                <person name="Baylis H.A."/>
                <person name="Jackson T.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="E2306" last="E2315">
            <title>RAB-10-GTPase-mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate.</title>
            <authorList>
                <person name="Shi A."/>
                <person name="Liu O."/>
                <person name="Koenig S."/>
                <person name="Banerjee R."/>
                <person name="Chen C.C."/>
                <person name="Eimer S."/>
                <person name="Grant B.D."/>
            </authorList>
            <dbReference type="PubMed" id="22869721"/>
            <dbReference type="DOI" id="10.1073/pnas.1205278109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH RAB-10; RAB-8 AND RAB-35</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2014" name="Nat. Struct. Mol. Biol." volume="21" first="1082" last="1090">
            <title>Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway.</title>
            <authorList>
                <person name="Nakagawa A."/>
                <person name="Sullivan K.D."/>
                <person name="Xue D."/>
            </authorList>
            <dbReference type="PubMed" id="25383666"/>
            <dbReference type="DOI" id="10.1038/nsmb.2915"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>PROTEOLYTIC CLEAVAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF LYS-284; ASP-382; ASP-508 AND ASP-609</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9XXH8-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_058803"/>
        </isoform>
        <isoform>
            <id>Q9XXH8-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022413.1">
        <property type="nucleotide sequence ID" value="NM_001027242.4"/>
    </dbReference>
    <dbReference type="WormBase" id="Y17G7B.15b">
        <property type="protein sequence ID" value="CE25223"/>
        <property type="gene ID" value="WBGene00000565"/>
        <property type="gene designation" value="cnt-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="25383666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="CAA10735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y17G7B.15a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y17G7B.15b"/>
        </source>
    </evidence>
    <sequence length="742" mass="81591" checksum="B08C7E5EF44C174F" modified="2001-10-01" version="2" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>S6F562</accession>
    <name>S6F562_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">pqn-21</name>
        <name evidence="5" type="ORF">C37A2.5</name>
        <name evidence="3" type="ORF">CELE_C37A2.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDG24122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293280.1">
        <property type="nucleotide sequence ID" value="NM_001306351.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6F562"/>
    <dbReference type="SMR" id="S6F562"/>
    <dbReference type="GeneID" id="172398"/>
    <dbReference type="AGR" id="WB:WBGene00004111"/>
    <dbReference type="CTD" id="172398"/>
    <dbReference type="WormBase" id="C37A2.5c">
        <property type="protein sequence ID" value="CE48461"/>
        <property type="gene ID" value="WBGene00004111"/>
        <property type="gene designation" value="pqn-21"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356117_0_0_1"/>
    <dbReference type="OrthoDB" id="5877875at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004111">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6F562">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDG24122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C37A2.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="S6F562"/>
        </source>
    </evidence>
    <sequence length="649" mass="70473" checksum="B2A1E1650CA5CDE0" modified="2013-10-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>S6F568</accession>
    <name>S6F568_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">hum-4</name>
        <name evidence="18" type="ORF">CELE_F46C3.3</name>
        <name evidence="20" type="ORF">F46C3.3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDG24127.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360186.1">
        <property type="nucleotide sequence ID" value="NM_001373506.3"/>
    </dbReference>
    <dbReference type="SMR" id="S6F568"/>
    <dbReference type="PeptideAtlas" id="S6F568"/>
    <dbReference type="GeneID" id="181335"/>
    <dbReference type="AGR" id="WB:WBGene00002037"/>
    <dbReference type="CTD" id="181335"/>
    <dbReference type="WormBase" id="F46C3.3f">
        <property type="protein sequence ID" value="CE53251"/>
        <property type="gene ID" value="WBGene00002037"/>
        <property type="gene designation" value="hum-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_14_0_1"/>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002037">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6F568">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14874">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heavy chain, Unconventional Myosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000011">
        <property type="entry name" value="Myosin 10A, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
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    </dbReference>
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        <property type="entry name" value="MYO15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
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    </dbReference>
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        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26570">
        <property type="entry name" value="MYO15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
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</entry>
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    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y67D8A.2k"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="U4PCE2"/>
        </source>
    </evidence>
    <sequence length="254" mass="28248" checksum="5A0E27CBB54D9FA1" modified="2013-12-11" version="1">MPVNFYDRVWTILERSTHGIIIADQFLPQQPTLSDMTRFELTFSYKIEAMLSRISHPEYRQLLVELLSIIATILERNPEIAFTHSRIDCDSLIKKGFALFAAEEGIKDLNDLTPFYQLEGQALSTSTATFLTKAVVEFILAGRHFSQVINIFGEGTPEEKTLPSQHHRGKMPKIAYTGRASSEKKKRHVGGSSSSSQHHHHHQQQQTPLLRLATPLTPEPSSGTVTPRAITPSPLSSSLNTSGGGGQDESCRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCE7</accession>
    <name>U4PCE7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1902 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y69A2AR.1</name>
        <name evidence="1 3" type="ORF">Y69A2AR.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294604.1">
        <property type="nucleotide sequence ID" value="NM_001307675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCE7"/>
    <dbReference type="PeptideAtlas" id="U4PCE7"/>
    <dbReference type="GeneID" id="177051"/>
    <dbReference type="AGR" id="WB:WBGene00022074"/>
    <dbReference type="CTD" id="177051"/>
    <dbReference type="WormBase" id="Y69A2AR.1h">
        <property type="protein sequence ID" value="CE48891"/>
        <property type="gene ID" value="WBGene00022074"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044520_0_0_1"/>
    <dbReference type="OrthoDB" id="5780950at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022074">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCE7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y69A2AR.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="U4PCE7"/>
        </source>
    </evidence>
    <sequence length="142" mass="16556" checksum="A3B84CEAFFF3A5E4" modified="2013-12-11" version="1">MRGAYATGERVYVCVRNDLRRAFKYSLAMPATAFKMSIGNEQLLLFTKSVPVFHCFFRTNVDEQGVVQLITEWQKGERNIEEIQLHLDRVIEPNFVDHLNADHADPKRVKVRRVVNGRKTTLYIERDRLGSRHLALRTLDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCF3</accession>
    <name>U4PCF3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CELE_Y69A2AR.16</name>
        <name evidence="9 11" type="ORF">Y69A2AR.16</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCF3"/>
    <dbReference type="SMR" id="U4PCF3"/>
    <dbReference type="PeptideAtlas" id="U4PCF3"/>
    <dbReference type="AGR" id="WB:WBGene00022087"/>
    <dbReference type="WormBase" id="Y69A2AR.16d">
        <property type="protein sequence ID" value="CE48544"/>
        <property type="gene ID" value="WBGene00022087"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009881_0_0_1"/>
    <dbReference type="OrthoDB" id="5548448at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022087">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCF3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDH93413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y69A2AR.16d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="U4PCF3"/>
        </source>
    </evidence>
    <sequence length="194" mass="22185" checksum="4E36F0350A7B11E9" modified="2013-12-11" version="1">MLLTIMNDRVLQMPEVALKFFRLILYLVEFSPESLAEMSDQLMSSLCQCIRLGMTGQFGMEITSTSLESLTEVVLHFGSPANKGRCTQNLAFLFKEMLPTVFETCLSNTCENSIYAESCSALYALIAFERSFFDEYVNELFSKKSNQQARQVLEAAFTELMEVNPEPGNRRGRVQFRSRMEQFLNKIQGLLSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCF9</accession>
    <name>U4PCF9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y69A2AR.32</name>
        <name evidence="2 4" type="ORF">Y69A2AR.32</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCF9"/>
    <dbReference type="AGR" id="WB:WBGene00022101"/>
    <dbReference type="WormBase" id="Y69A2AR.32c">
        <property type="protein sequence ID" value="CE48965"/>
        <property type="gene ID" value="WBGene00022101"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_720095_0_0_1"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022101">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCF9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y69A2AR.32c"/>
        </source>
    </evidence>
    <sequence length="48" mass="5492" checksum="C68A1EE576263898" modified="2013-12-11" version="1">MMKVTQYGAGDTSSRKNLPYPPPLMSTPMPPPGYSMCYMMPPYYPPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCH6</accession>
    <name>U4PCH6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WAPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">wapl-1</name>
        <name evidence="2" type="ORF">CELE_R08C7.10</name>
        <name evidence="4" type="ORF">R08C7.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368334.1">
        <property type="nucleotide sequence ID" value="NM_001380189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCH6"/>
    <dbReference type="SMR" id="U4PCH6"/>
    <dbReference type="PeptideAtlas" id="U4PCH6"/>
    <dbReference type="GeneID" id="177211"/>
    <dbReference type="AGR" id="WB:WBGene00019953"/>
    <dbReference type="CTD" id="177211"/>
    <dbReference type="WormBase" id="R08C7.10e">
        <property type="protein sequence ID" value="CE49074"/>
        <property type="gene ID" value="WBGene00019953"/>
        <property type="gene designation" value="wapl-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371419_0_0_1"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019953">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCH6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R08C7.10e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PCH6"/>
        </source>
    </evidence>
    <sequence length="102" mass="11817" checksum="DB2D68C0057A042A" modified="2013-12-11" version="1">MDRMDQVDVVHALQQVMNKASAHMEGSVIASYHALLVGFVLQQNEDHLDEVRKHLPGKNFQNMISQLKRLYDFTKATMAKRVESNSGFRAIERVIEYLERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCH9</accession>
    <name>U4PCH9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">unc-77</name>
        <name evidence="27" type="ORF">C11D2.6</name>
        <name evidence="25" type="ORF">CELE_C11D2.6</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294631.1">
        <property type="nucleotide sequence ID" value="NM_001307702.3"/>
    </dbReference>
    <dbReference type="SMR" id="U4PCH9"/>
    <dbReference type="GeneID" id="177379"/>
    <dbReference type="AGR" id="WB:WBGene00006809"/>
    <dbReference type="CTD" id="177379"/>
    <dbReference type="WormBase" id="C11D2.6e">
        <property type="protein sequence ID" value="CE48791"/>
        <property type="gene ID" value="WBGene00006809"/>
        <property type="gene designation" value="unc-77"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006809">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCH9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000089">
        <property type="entry name" value="Four domain-type voltage-gated ion channel alpha-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000080">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000060">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000061">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000066">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000030">
        <property type="entry name" value="sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000032">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000034">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF2">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="890"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="935"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="970"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1032"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1146"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1227"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1259"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1299"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1333"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1371"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1456"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="81"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="429"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="896"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="1225"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1659"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1668"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="1684"/>
            <end position="1694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDH93441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="C11D2.6e"/>
        </source>
    </evidence>
    <sequence length="1798" mass="207976" checksum="AEBAA41B2A2C0A24" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCI9</accession>
    <name>U4PCI9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LIn-26 Related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">lir-1</name>
        <name evidence="1" type="ORF">CELE_F18A1.3</name>
        <name evidence="3" type="ORF">F18A1.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380148.1">
        <property type="nucleotide sequence ID" value="NM_001393123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCI9"/>
    <dbReference type="SMR" id="U4PCI9"/>
    <dbReference type="GeneID" id="174240"/>
    <dbReference type="AGR" id="WB:WBGene00003044"/>
    <dbReference type="CTD" id="174240"/>
    <dbReference type="WormBase" id="F18A1.3f">
        <property type="protein sequence ID" value="CE48550"/>
        <property type="gene ID" value="WBGene00003044"/>
        <property type="gene designation" value="lir-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5775637at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003044">
        <property type="expression patterns" value="Expressed in embryo and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCI9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F18A1.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="U4PCI9"/>
        </source>
    </evidence>
    <sequence length="236" mass="27006" checksum="AD8748B9F70C2D6D" modified="2013-12-11" version="1">MLLQLNDEERQRLMKMISTPGPQTLSMERIQMAPGQGQHILQQHQIPSTSSYTNNSFIYIKSDPQYKDEPQQQSNQFDATVNSVAHGQAGLSTLEMFACNGSPNGGDVLRRKTPSRKAEDSIKATCKVCGHDVMYSPQRTWNLMRHVWIMHQSSKPNQCSICGYSHIKPYVRKHIESQHKHDSNATIIDLKSPELEAEWSQLLDQCFGVTYRKWKHHKEDTQHTGGLLFDDDELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLA3</accession>
    <name>V6CLA3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">skn-1</name>
        <name evidence="8" type="ORF">CELE_T19E7.2</name>
        <name evidence="10" type="ORF">T19E7.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368358.1">
        <property type="nucleotide sequence ID" value="NM_001380238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLA3"/>
    <dbReference type="SMR" id="V6CLA3"/>
    <dbReference type="GeneID" id="177343"/>
    <dbReference type="AGR" id="WB:WBGene00004804"/>
    <dbReference type="CTD" id="177343"/>
    <dbReference type="WormBase" id="T19E7.2d">
        <property type="protein sequence ID" value="CE49174"/>
        <property type="gene ID" value="WBGene00004804"/>
        <property type="gene designation" value="skn-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_511149_0_0_1"/>
    <dbReference type="OrthoDB" id="7458135at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004804">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLA3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF55">
        <property type="entry name" value="SEGMENTATION PROTEIN CAP'N'COLLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDK13323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="T19E7.2d"/>
        </source>
    </evidence>
    <sequence length="223" mass="24886" checksum="800B61A49643E014" modified="2014-02-19" version="1">MQNDSLQAVVSNGQIDYDHSYQSTGQTPLSPLIIGSSGRQQQTQTSPGSVTVTATATQSLFDPYHSQRHSFSDCTTDSSSTCSRLSSESPRYTSESSTGTHESRFYGKLAPSSGSRYQRSSSPRSSQSSIKIARVVPLASGQRKRGRQSKDEQLASDNELPVSAFQISEMSLSELQQVLKNESLSEYQRQLIRKIRRRGKNKVAARTCRQRRTDRHDKMSHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLA6</accession>
    <name>V6CLA6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y95B8A.6</name>
        <name evidence="3 5" type="ORF">Y95B8A.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLA6"/>
    <dbReference type="SMR" id="V6CLA6"/>
    <dbReference type="AGR" id="WB:WBGene00022386"/>
    <dbReference type="WormBase" id="Y95B8A.6d">
        <property type="protein sequence ID" value="CE49476"/>
        <property type="gene ID" value="WBGene00022386"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1385288_0_0_1"/>
    <dbReference type="OrthoDB" id="5977230at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022386">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLA6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004744493" evidence="2">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y95B8A.6d"/>
        </source>
    </evidence>
    <sequence length="197" mass="23256" checksum="0E555AE297A9BED2" modified="2014-02-19" version="1">MHMFHHVLLLLLLRVLPCFTQFQVLYRENQDHIWNSSQPVRFWELVEYRPTTTPPPTTTTEYIPPPTTTPTTTTTTKDPCESSHPLDLTRRLRDTAGYNRIYMASDFSSARNEFPDLRGLAHKASTDYHCGKRCQRSSQLIRKIIKTGQPAEAERAWWDEEEWEEGERRRKRAIEWKDTDDRLLMRNTGTSRHILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLA7</accession>
    <name>V6CLA7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">hecd-1</name>
        <name evidence="16" type="ORF">C34D4.14</name>
        <name evidence="14" type="ORF">CELE_C34D4.14</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="10"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368365.1">
        <property type="nucleotide sequence ID" value="NM_001380312.2"/>
    </dbReference>
    <dbReference type="SMR" id="V6CLA7"/>
    <dbReference type="PeptideAtlas" id="V6CLA7"/>
    <dbReference type="GeneID" id="177486"/>
    <dbReference type="AGR" id="WB:WBGene00016405"/>
    <dbReference type="CTD" id="177486"/>
    <dbReference type="WormBase" id="C34D4.14f">
        <property type="protein sequence ID" value="CE49319"/>
        <property type="gene ID" value="WBGene00016405"/>
        <property type="gene designation" value="hecd-1"/>
    </dbReference>
    <dbReference type="OMA" id="INHTLTM"/>
    <dbReference type="OrthoDB" id="412600at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016405">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLA7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031581">
        <property type="term" value="P:hemidesmosome assembly"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000320">
        <property type="entry name" value="E3 ubiquitin-protein ligase hecd-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000033">
        <property type="entry name" value="E3 ubiquitin-protein ligase hecd-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000051">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000033">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000007">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="13">
        <location>
            <begin position="1440"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="12">
        <location>
            <begin position="2242"/>
            <end position="2650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="433"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="645"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1378"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1540"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1577"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1654"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1813"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1385"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1545"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1577"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1612"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1655"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1669"/>
            <end position="1698"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1738"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1758"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1814"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="2619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDK13344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="C34D4.14f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLA7"/>
        </source>
    </evidence>
    <sequence length="2650" mass="292451" checksum="8A4699D1F6EA59B0" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLA8</accession>
    <name>V6CLA8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Endoplasmic reticulum oxidoreductin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">ero-1</name>
        <name evidence="17" type="ORF">CELE_Y105E8B.8</name>
        <name evidence="19" type="ORF">Y105E8B.8</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293161.1">
        <property type="nucleotide sequence ID" value="NM_001306232.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLA8"/>
    <dbReference type="SMR" id="V6CLA8"/>
    <dbReference type="PeptideAtlas" id="V6CLA8"/>
    <dbReference type="GeneID" id="173325"/>
    <dbReference type="KEGG" id="cel:CELE_Y105E8B.8"/>
    <dbReference type="AGR" id="WB:WBGene00001334"/>
    <dbReference type="CTD" id="173325"/>
    <dbReference type="WormBase" id="Y105E8B.8e">
        <property type="protein sequence ID" value="CE23207"/>
        <property type="gene ID" value="WBGene00001334"/>
        <property type="gene designation" value="ero-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023061_2_2_1"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001334">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLA8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDK13328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="Y105E8B.8e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLA8"/>
        </source>
    </evidence>
    <sequence length="250" mass="28846" checksum="DB38A36A39700968" modified="2014-02-19" version="1">MCLEKRVFYRLISGLHSAITISIAAYNYKPPPPSLGQFGSQMGTWFRNTEMFAGRFGTKWSWEGPQRLRNVYFIYLLELRALLKAAPYLQNELFYTGNDVEDAETRKAVEDLLEEIRAYPNHFDESEMFTGVESHARALREEFRSHFVNISRIMDCVECDKCRLWGKVQTHGMGTALKILFSDLPHSHYKQDSSKFQLTRNEVVALLQSFGRYSSSILEVDNFREDMYPGESVMNTAADGPPRKSNKIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLB0</accession>
    <name>V6CLB0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C42D4.13</name>
        <name evidence="1" type="ORF">CELE_C42D4.13</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293709.1">
        <property type="nucleotide sequence ID" value="NM_001306780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLB0"/>
    <dbReference type="GeneID" id="183405"/>
    <dbReference type="KEGG" id="cel:CELE_C42D4.13"/>
    <dbReference type="AGR" id="WB:WBGene00016598"/>
    <dbReference type="CTD" id="183405"/>
    <dbReference type="WormBase" id="C42D4.13b">
        <property type="protein sequence ID" value="CE49129"/>
        <property type="gene ID" value="WBGene00016598"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127280_0_0_1"/>
    <dbReference type="OrthoDB" id="5799752at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016598">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLB0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C42D4.13b"/>
        </source>
    </evidence>
    <sequence length="128" mass="14365" checksum="522DF1393E5812AB" modified="2014-02-19" version="1">MNFIGATTEPRRTIPKQADGTDCPMPPECGCLCGRSGRKKRETGEFWKNTEEPESEIRCTSGKLRRVVEKAISKATKEGIQFDLGVNSLTNYVLFCQAEKFKNLQFSTDSTKFCQVSRGPVNCLIIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLB1</accession>
    <name>V6CLB1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">zen-4</name>
        <name evidence="8" type="ORF">CELE_M03D4.1</name>
        <name evidence="10" type="ORF">M03D4.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360295.1">
        <property type="nucleotide sequence ID" value="NM_001372838.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLB1"/>
    <dbReference type="SMR" id="V6CLB1"/>
    <dbReference type="GeneID" id="177374"/>
    <dbReference type="AGR" id="WB:WBGene00006974"/>
    <dbReference type="CTD" id="177374"/>
    <dbReference type="WormBase" id="M03D4.1e">
        <property type="protein sequence ID" value="CE49163"/>
        <property type="gene ID" value="WBGene00006974"/>
        <property type="gene designation" value="zen-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2403182at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006974">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLB1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4330">
        <property type="entry name" value="Kinesin-like protein Kif23, Arf6-interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032384">
        <property type="entry name" value="Kif23_Arf-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038105">
        <property type="entry name" value="Kif23_Arf-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF600">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16540">
        <property type="entry name" value="MKLP1_Arf_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="27"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDK13349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="M03D4.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLB1"/>
        </source>
    </evidence>
    <sequence length="774" mass="87674" checksum="BE5CA7F53D5A902B" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLB2</accession>
    <name>V6CLB2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myotubularin phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mtm-10</name>
        <name evidence="2" type="ORF">CELE_Y48G1C.10</name>
        <name evidence="4" type="ORF">Y48G1C.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293166.1">
        <property type="nucleotide sequence ID" value="NM_001306237.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLB2"/>
    <dbReference type="PeptideAtlas" id="V6CLB2"/>
    <dbReference type="GeneID" id="353378"/>
    <dbReference type="AGR" id="WB:WBGene00021683"/>
    <dbReference type="CTD" id="353378"/>
    <dbReference type="WormBase" id="Y48G1C.10c">
        <property type="protein sequence ID" value="CE49384"/>
        <property type="gene ID" value="WBGene00021683"/>
        <property type="gene designation" value="mtm-10"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371422_0_0_1"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021683">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLB2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y48G1C.10c"/>
        </source>
    </evidence>
    <sequence length="97" mass="11021" checksum="AB4A0C06CEF5B325" modified="2014-02-19" version="1">MRPKEQIVGYSKYAFDDSLSPRPHSRTVETPILKNSPSPSYTPFHPTPVHRSNTVRADNRPIPPPRPQGLGTLTPSRPEIRAHRDDIESPTIRVTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLB4</accession>
    <name>V6CLB4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mtrf-1l</name>
        <name evidence="2" type="synonym">mtrf-1L</name>
        <name evidence="2" type="ORF">CELE_W03F8.3</name>
        <name evidence="4" type="ORF">W03F8.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368375.1">
        <property type="nucleotide sequence ID" value="NM_001380217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLB4"/>
    <dbReference type="SMR" id="V6CLB4"/>
    <dbReference type="PeptideAtlas" id="V6CLB4"/>
    <dbReference type="GeneID" id="177294"/>
    <dbReference type="AGR" id="WB:WBGene00020993"/>
    <dbReference type="WormBase" id="W03F8.3b">
        <property type="protein sequence ID" value="CE49339"/>
        <property type="gene ID" value="WBGene00020993"/>
        <property type="gene designation" value="mtrf-1L"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_3_1"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020993">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLB4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="W03F8.3b"/>
        </source>
    </evidence>
    <sequence length="87" mass="10178" checksum="88206F0AC93AEB2C" modified="2014-02-19" version="1">MQKQVDAMLEKIVSKRKLQVGSKARAEKIRTYNFQHDRVTDHRIQMSITGVAEFLSAGETLQTMIERLQEQHLEDRLDHIIENCIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLB5</accession>
    <name>V6CLB5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">kola-3</name>
        <name evidence="3" type="ORF">C01B10.6</name>
        <name evidence="1" type="ORF">CELE_C01B10.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368370.1">
        <property type="nucleotide sequence ID" value="NM_001380285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLB5"/>
    <dbReference type="SMR" id="V6CLB5"/>
    <dbReference type="GeneID" id="177432"/>
    <dbReference type="AGR" id="WB:WBGene00015280"/>
    <dbReference type="CTD" id="177432"/>
    <dbReference type="WormBase" id="C01B10.6d">
        <property type="protein sequence ID" value="CE49285"/>
        <property type="gene ID" value="WBGene00015280"/>
        <property type="gene designation" value="kola-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3261023_0_0_1"/>
    <dbReference type="OrthoDB" id="5868648at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015280">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLB5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C01B10.6d"/>
        </source>
    </evidence>
    <sequence length="42" mass="4995" checksum="33D217D3A2660589" modified="2014-02-19" version="1">MQQIRPNHQQTQVLYQHLQLLKMPVKNDSINTYNSQNALINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLB6</accession>
    <name>V6CLB6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">cyn-12</name>
        <name evidence="3" type="ORF">C34D4.12</name>
        <name evidence="1" type="ORF">CELE_C34D4.12</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368362.1">
        <property type="nucleotide sequence ID" value="NM_001380307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLB6"/>
    <dbReference type="SMR" id="V6CLB6"/>
    <dbReference type="PeptideAtlas" id="V6CLB6"/>
    <dbReference type="GeneID" id="191627"/>
    <dbReference type="KEGG" id="cel:CELE_C34D4.12"/>
    <dbReference type="AGR" id="WB:WBGene00000888"/>
    <dbReference type="CTD" id="191627"/>
    <dbReference type="WormBase" id="C34D4.12b">
        <property type="protein sequence ID" value="CE49222"/>
        <property type="gene ID" value="WBGene00000888"/>
        <property type="gene designation" value="cyn-12"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3360206_0_0_1"/>
    <dbReference type="OrthoDB" id="5916692at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000888">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLB6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C34D4.12b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLB6"/>
        </source>
    </evidence>
    <sequence length="36" mass="4085" checksum="8E5BA66210EE27CE" modified="2014-02-19" version="1">MKVIANMGRVDTDNHDRPKIEIRILKAYPSESSVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLC0</accession>
    <name>V6CLC0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">hecd-1</name>
        <name evidence="16" type="ORF">C34D4.14</name>
        <name evidence="14" type="ORF">CELE_C34D4.14</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="10"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368364.1">
        <property type="nucleotide sequence ID" value="NM_001380311.1"/>
    </dbReference>
    <dbReference type="SMR" id="V6CLC0"/>
    <dbReference type="PeptideAtlas" id="V6CLC0"/>
    <dbReference type="GeneID" id="177486"/>
    <dbReference type="AGR" id="WB:WBGene00016405"/>
    <dbReference type="CTD" id="177486"/>
    <dbReference type="WormBase" id="C34D4.14e">
        <property type="protein sequence ID" value="CE49371"/>
        <property type="gene ID" value="WBGene00016405"/>
        <property type="gene designation" value="hecd-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412600at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016405">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLC0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000320">
        <property type="entry name" value="E3 ubiquitin-protein ligase hecd-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000033">
        <property type="entry name" value="E3 ubiquitin-protein ligase hecd-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000051">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000033">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000007">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="13">
        <location>
            <begin position="1436"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="12">
        <location>
            <begin position="2238"/>
            <end position="2646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <dbReference type="ARBA" id="ARBA00006331"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDK13343.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="C34D4.14e"/>
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    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLC0"/>
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    </evidence>
    <sequence length="2646" mass="292009" checksum="2C69B9DA1DB92276" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLC1</accession>
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        <submittedName>
            <fullName evidence="13">Fork-head domain-containing protein</fullName>
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        <name evidence="13 15" type="primary">fkh-7</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">Bristol N2</strain>
        </source>
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    </evidence>
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</entry>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="cel:CELE_Y18H1A.8"/>
    <dbReference type="AGR" id="WB:WBGene00021212"/>
    <dbReference type="CTD" id="171667"/>
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        <property type="gene ID" value="WBGene00021212"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141211_0_0_1"/>
    <dbReference type="OrthoDB" id="10532029at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021212">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLC4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y18H1A.8b"/>
        </source>
    </evidence>
    <sequence length="64" mass="7320" checksum="D114348075CF4D67" modified="2014-02-19" version="1">MIIVHDCTDNGKYKLLTVDLGSYYIKDGQYDETRNIDLNNAGEWTNEVIGTKAMVMSKIFIFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLC6</accession>
    <name>V6CLC6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 18">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="12">IMP dehydrogenase</shortName>
            <shortName evidence="12">IMPD</shortName>
            <shortName evidence="12">IMPDH</shortName>
            <ecNumber evidence="12 18">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CELE_T22D1.3</name>
        <name evidence="20 22" type="ORF">T22D1.3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12 18">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 18">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 17">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="12 18"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293729.1">
        <property type="nucleotide sequence ID" value="NM_001306800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLC6"/>
    <dbReference type="SMR" id="V6CLC6"/>
    <dbReference type="PeptideAtlas" id="V6CLC6"/>
    <dbReference type="GeneID" id="177457"/>
    <dbReference type="AGR" id="WB:WBGene00020682"/>
    <dbReference type="CTD" id="177457"/>
    <dbReference type="WormBase" id="T22D1.3c">
        <property type="protein sequence ID" value="CE49453"/>
        <property type="gene ID" value="WBGene00020682"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020682">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLC6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000086">
        <property type="entry name" value="IMP dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 16" id="KW-0129">CBS domain</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12 18" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 12 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 14" id="KW-0520">NAD</keyword>
    <keyword evidence="7 12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 12 15" id="KW-0630">Potassium</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5 12 18" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="19">
        <location>
            <begin position="178"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="12 13">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12 13">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <begin position="280"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12 15">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12 15">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12 15">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="370"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="393"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="418"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDK13407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="T22D1.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLC6"/>
        </source>
    </evidence>
    <sequence length="522" mass="56873" checksum="E40AF78D7A65F5E6" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLC8</accession>
    <name>V6CLC8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">kola-3</name>
        <name evidence="6" type="ORF">C01B10.6</name>
        <name evidence="4" type="ORF">CELE_C01B10.6</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368369.1">
        <property type="nucleotide sequence ID" value="NM_001380284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLC8"/>
    <dbReference type="SMR" id="V6CLC8"/>
    <dbReference type="GeneID" id="177432"/>
    <dbReference type="KEGG" id="cel:CELE_C01B10.6"/>
    <dbReference type="AGR" id="WB:WBGene00015280"/>
    <dbReference type="CTD" id="177432"/>
    <dbReference type="WormBase" id="C01B10.6c">
        <property type="protein sequence ID" value="CE49389"/>
        <property type="gene ID" value="WBGene00015280"/>
        <property type="gene designation" value="kola-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039102_0_0_1"/>
    <dbReference type="OrthoDB" id="5868648at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015280">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLC8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="230"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDK13354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C01B10.6c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLC8"/>
        </source>
    </evidence>
    <sequence length="423" mass="44002" checksum="6D839C34BAEDFA92" modified="2014-02-19" version="1">MKFSTFPVSNDVSVLDAKLILQQAVQLDQQINELNTFLINAQADTNPNNSPLFAQLTAFSNNITSQNATLQGYITKLNALTATQASINTRLDSATNTFVCFSQSSCVTDVPTTPEPTSPGSTPAVTECTNTTLTATLDTPQTHPQPSTQNAAQCVVSVKAYTSTNNVNITISASFTGNDAFVKLVETRTQESVTINGTVSNYTFSGFQQVDVYYYSGPRSTVQFNFDYVEVNNCKLNCTGDNGKCIVSQSGQQYCECKKCEFSGTNCETTLPDPCQSKQKRACGQNALSPYGVCYKNICSDQCFSCACSPGAKSPPDQSCPKPSPTDPTPVPPVAPTPPSVCPTTVAPTTTPALLTSTIAPTADVTSATNAAGSTGATGSSATGSTVTSDVASSSATGGSSTNATDTTQSSTDASTVSTSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLD0</accession>
    <name>V6CLD0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">col-47</name>
        <name evidence="4" type="ORF">CELE_Y18H1A.12</name>
        <name evidence="6" type="ORF">Y18H1A.12</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293182.1">
        <property type="nucleotide sequence ID" value="NM_001306253.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLD0"/>
    <dbReference type="GeneID" id="4363004"/>
    <dbReference type="AGR" id="WB:WBGene00000624"/>
    <dbReference type="CTD" id="4363004"/>
    <dbReference type="WormBase" id="Y18H1A.12b">
        <property type="protein sequence ID" value="CE49234"/>
        <property type="gene ID" value="WBGene00000624"/>
        <property type="gene designation" value="col-47"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001074_4_3_1"/>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000624">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLD0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF263">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDK13370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y18H1A.12b"/>
        </source>
    </evidence>
    <sequence length="172" mass="16798" checksum="51AA4F8935A5805E" modified="2014-02-19" version="1">MDGEAGHSNMDVFMSPTGCIRCPAGPPGSPGDHGSPGEPGYPGPSGPPGEPGYATIGLIGPPGLAGQDGLDGAPGEPGVGGMDAVKIVSVDGKIGRRGEAGNKGSKGSRGGVGKAGGPGVAGEMGEKGARGEDGKPGESGKPGAPGIPGKDGTYCRCPDRNRYDIYPYKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLD4</accession>
    <name>V6CLD4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rap-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">hgap-1</name>
        <name evidence="4" type="ORF">CELE_Y18H1A.3</name>
        <name evidence="6" type="ORF">Y18H1A.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293171.1">
        <property type="nucleotide sequence ID" value="NM_001306242.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLD4"/>
    <dbReference type="SMR" id="V6CLD4"/>
    <dbReference type="GeneID" id="171663"/>
    <dbReference type="AGR" id="WB:WBGene00021209"/>
    <dbReference type="CTD" id="171663"/>
    <dbReference type="WormBase" id="Y18H1A.3d">
        <property type="protein sequence ID" value="CE49407"/>
        <property type="gene ID" value="WBGene00021209"/>
        <property type="gene designation" value="hgap-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006276_0_0_1"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021209">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLD4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF11">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="742"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDK13359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y18H1A.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLD4"/>
        </source>
    </evidence>
    <sequence length="967" mass="107404" checksum="B806153FC6008990" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLD5</accession>
    <name>V6CLD5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adiponectin receptor protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">paqr-1</name>
        <name evidence="11" type="ORF">C43G2.1</name>
        <name evidence="9" type="ORF">CELE_C43G2.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368383.1">
        <property type="nucleotide sequence ID" value="NM_001380279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLD5"/>
    <dbReference type="SMR" id="V6CLD5"/>
    <dbReference type="GeneID" id="177416"/>
    <dbReference type="AGR" id="WB:WBGene00016610"/>
    <dbReference type="CTD" id="177416"/>
    <dbReference type="WormBase" id="C43G2.1b">
        <property type="protein sequence ID" value="CE49134"/>
        <property type="gene ID" value="WBGene00016610"/>
        <property type="gene designation" value="paqr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023075_1_0_1"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016610">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLD5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF127">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDK13417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C43G2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLD5"/>
        </source>
    </evidence>
    <sequence length="335" mass="38909" checksum="4A71D96AAAC6BD53" modified="2014-02-19" version="1">MPKHTILRYRRKKGGQWREINLQGTPDKRKDDEDELEVDVKEDRSEQTGIVTKTYEARWKVLKYEHLPEWLQDNEFLRHGHRPPLPSFSECFKSIWSLHTETGNIWTHLIGCVAFFFLACWFLTRPDNHIQFQEKVVFSFFFAGAVLCLGLSFAFHTLSCHSVNVVKIFCKLDYMGISLLIIGSFIPWIYYGFYCRREPKITYIAMVSVLGIGAIVVSLWDKFSESRFRPIRAAVFVGMGCSGVIPTIHYIITDGVHSLFADNSFHWLLLMAFLYLLGAGLYATRTPERFFPGKCDIWFQSHQLFHTCVVIAAFVHYYGISEMAFARLNEQCPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLD8</accession>
    <name>V6CLD8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">rec-1</name>
        <name evidence="1" type="ORF">CELE_Y18H1A.7</name>
        <name evidence="3" type="ORF">Y18H1A.7</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293176.1">
        <property type="nucleotide sequence ID" value="NM_001306247.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLD8"/>
    <dbReference type="GeneID" id="171664"/>
    <dbReference type="KEGG" id="cel:CELE_Y18H1A.7"/>
    <dbReference type="AGR" id="WB:WBGene00004332"/>
    <dbReference type="CTD" id="171664"/>
    <dbReference type="WormBase" id="Y18H1A.7b">
        <property type="protein sequence ID" value="CE49243"/>
        <property type="gene ID" value="WBGene00004332"/>
        <property type="gene designation" value="rec-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_750579_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004332">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLD8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y18H1A.7b"/>
        </source>
    </evidence>
    <sequence length="47" mass="5469" checksum="E09EFA13AB350395" modified="2014-02-19" version="1">MQLARFKALRLSKPSKNHRSSRQCAAISEKKSKIMMNSWAEDSIFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLF2</accession>
    <name>V6CLF2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Guanine nucleotide-binding protein alpha-16 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gpa-16</name>
        <name evidence="10" type="ORF">CELE_Y95B8A.5</name>
        <name evidence="12" type="ORF">Y95B8A.5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293187.1">
        <property type="nucleotide sequence ID" value="NM_001306258.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLF2"/>
    <dbReference type="SMR" id="V6CLF2"/>
    <dbReference type="GeneID" id="171675"/>
    <dbReference type="AGR" id="WB:WBGene00001678"/>
    <dbReference type="CTD" id="171675"/>
    <dbReference type="WormBase" id="Y95B8A.5c">
        <property type="protein sequence ID" value="CE49147"/>
        <property type="gene ID" value="WBGene00001678"/>
        <property type="gene designation" value="gpa-16"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLF2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF227">
        <property type="entry name" value="G PROTEIN ALPHA I SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="27"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDK13379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y95B8A.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLF2"/>
        </source>
    </evidence>
    <sequence length="115" mass="13571" checksum="05CB9326BC15548B" modified="2014-02-19" version="1">MRESLKLFDSICNNKWFVETSIILFLNKKDLFEEKIVRSPLTHCFPEYTGANNYEEASAYIQQQFEDMNKRTTGEKNQEIYTQFTCATDTNNIRFVFDAVTDIIIRDNLRTCGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLF3</accession>
    <name>V6CLF3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G Protein, Alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">gpa-18</name>
        <name evidence="6" type="ORF">CELE_W03F8.9</name>
        <name evidence="8" type="ORF">W03F8.9</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293718.1">
        <property type="nucleotide sequence ID" value="NM_001306789.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLF3"/>
    <dbReference type="SMR" id="V6CLF3"/>
    <dbReference type="PaxDb" id="6239-W03F8.9"/>
    <dbReference type="GeneID" id="189161"/>
    <dbReference type="KEGG" id="cel:CELE_W03F8.9"/>
    <dbReference type="AGR" id="WB:WBGene00020997"/>
    <dbReference type="CTD" id="189161"/>
    <dbReference type="WormBase" id="W03F8.9a">
        <property type="protein sequence ID" value="CE49465"/>
        <property type="gene ID" value="WBGene00020997"/>
        <property type="gene designation" value="gpa-18"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_776662_0_0_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020997">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLF3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF116">
        <property type="entry name" value="G PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="241"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDK13395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="W03F8.9a"/>
        </source>
    </evidence>
    <sequence length="318" mass="37278" checksum="DDFB2B09F5D9F4D9" modified="2014-02-19" version="1">MGSAGSVDRGPIRTLVLGCMGAGKTSFIRQMVKNHTKSICLRRELYLYCVQLNLLNIYRELKNVIEALEIPISEDQKQRFTQLDEYRHREVFPPKIIEAMKELFESGLYELCRLRQRILPLPQNYHFLFQRGDDFMNPEYVPSELEIMMSYSQTCGLNRENVTCQGYKFELLEMPGHHLWRAKWADYFDDPNLVVFVIDLSELCDPAFYNKGYLENKTVTVFESLVNNPVLAKVYWLLLFNKADTFNDHSAGFDFRKLANHLDTADSARSFYRSQFTTKISKTRCFPHIVSLVNESQSVMMEMFKKIGKMHRERPNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6RRP9</accession>
    <name>W6RRP9_CAEEL</name>
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        <submittedName>
            <fullName evidence="10">Solute carrier family 35 member F2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_Y73E7A.3</name>
        <name evidence="10 12" type="ORF">Y73E7A.3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative solute transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293405.1">
        <property type="nucleotide sequence ID" value="NM_001306476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RRP9"/>
    <dbReference type="SMR" id="W6RRP9"/>
    <dbReference type="GeneID" id="190665"/>
    <dbReference type="AGR" id="WB:WBGene00022270"/>
    <dbReference type="CTD" id="190665"/>
    <dbReference type="WormBase" id="Y73E7A.3c">
        <property type="protein sequence ID" value="CE49591"/>
        <property type="gene ID" value="WBGene00022270"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039639_4_1_1"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022270">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RRP9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM63461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y73E7A.3c"/>
        </source>
    </evidence>
    <sequence length="381" mass="42051" checksum="54AA7359339D3C27" modified="2014-04-16" version="1">MPTKDYSEIRRTFKALILGQILSLCLCGTGVSSQLLVNQNVNAPAAQAFSNYFLLCFVYCISLACKNDENGLVVVLRKRGWRYLILAIIDVEANYMIVKAYQYTNLTSVQLLDCATIPTVLFLSWLFLSVRYLASHILGVTICIIGIACVIWADALGDKGALDGGSNKVLGDILCLAAAVMYAICNVAEEFLVKQHSRTEYLGMLGLFGCIVSGVQTAVFEQEALSKIVWDGTIVSYFALFAFSMFIFYSLVTVVLQKTSALMFNLSTLTADFYSLLFGIFMFKDTFHYLYFVSFIVCIIGSVIYSMKETQVRDADEPRRVCPCLFVCCCCCGCCFEEGDSTEGSIDVSPSPNERMQMGLNPRGSMSPCPVHGGSQQLSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6RS00</accession>
    <name>W6RS00_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin-5AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">daf-42</name>
        <name evidence="3" type="ORF">CELE_Y40C5A.3</name>
        <name evidence="5" type="ORF">Y40C5A.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294191.1">
        <property type="nucleotide sequence ID" value="NM_001307262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="177507"/>
    <dbReference type="AGR" id="WB:WBGene00021496"/>
    <dbReference type="CTD" id="177507"/>
    <dbReference type="WormBase" id="Y40C5A.3q">
        <property type="protein sequence ID" value="CE49522"/>
        <property type="gene ID" value="WBGene00021496"/>
        <property type="gene designation" value="daf-42"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868414at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021496">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RS00">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881192" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM63552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y40C5A.3q"/>
        </source>
    </evidence>
    <sequence length="1412" mass="149921" checksum="35A4D9974BAE535C" modified="2014-04-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>W6RS03</accession>
    <name>W6RS03_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">herc-1</name>
        <name evidence="7" type="ORF">CELE_Y48G8AL.1</name>
        <name evidence="9" type="ORF">Y48G8AL.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001427161.1">
        <property type="nucleotide sequence ID" value="NM_001440228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RS03"/>
    <dbReference type="SMR" id="W6RS03"/>
    <dbReference type="PeptideAtlas" id="W6RS03"/>
    <dbReference type="GeneID" id="171700"/>
    <dbReference type="AGR" id="WB:WBGene00021685"/>
    <dbReference type="CTD" id="171700"/>
    <dbReference type="WormBase" id="Y48G8AL.1c">
        <property type="protein sequence ID" value="CE49524"/>
        <property type="gene ID" value="WBGene00021685"/>
        <property type="gene designation" value="herc-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_5_3_1"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021685">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RS03">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="312"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM63557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y48G8AL.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="W6RS03"/>
        </source>
    </evidence>
    <sequence length="643" mass="74595" checksum="2B7E7E124ECCABB0" modified="2014-04-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>W6RS06</accession>
    <name>W6RS06_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">pitr-1</name>
        <name evidence="12" type="ORF">C48A7.2</name>
        <name evidence="10" type="ORF">CELE_C48A7.2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368450.1">
        <property type="nucleotide sequence ID" value="NM_001380321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RS06"/>
    <dbReference type="SMR" id="W6RS06"/>
    <dbReference type="GeneID" id="177512"/>
    <dbReference type="AGR" id="WB:WBGene00016739"/>
    <dbReference type="CTD" id="177512"/>
    <dbReference type="WormBase" id="C48A7.2b">
        <property type="protein sequence ID" value="CE49582"/>
        <property type="gene ID" value="WBGene00016739"/>
        <property type="gene designation" value="pitr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_3_1_1"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016739">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RS06">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM63562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C48A7.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="W6RS06"/>
        </source>
    </evidence>
    <sequence length="462" mass="50505" checksum="323F29E44568AF11" modified="2014-04-16" version="1">MRKGVIDFSEFGKHENGTVLMSENDLGHTIMLGQIAILTGCGVWMLLATAFKLPVSTTHSIVGATIGFALVAQGSRVIVWEKIYRIFFSWIISPLLSGIVSVFIYLSLDHLVLRREQPLHSGIRVLPALYFICFAFNVFAIVYKGPSFLYFDRLSLTQCLIISGVFGLAVALIFAFFLAPYLKDHILSKELLEITGKQRHSHHGHNEKSSSKRKEFEMEEGNGKYLESDNNGQPLLDQPTIVVSTCPSNGESTSSFAKNTIRPSSSLASFFRSCKPEDPQASRLFSLLQVMTACFGGFAHGGNDVSNAIAPLVSLYLIANDGMKSADMETPWYLLLYGSFGMCLGLWVLGHRVIYTVGENLTKITPASGFAVEFGAAVTVLIASKLGLPISSTQCKVGSVVAVGLVQSRHQVHWGVFRNISLSWIVTLPVAGLLSGGTMMILHLFSFGTDATPKDSILQLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6RS16</accession>
    <name>W6RS16_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">rml-5</name>
        <name evidence="1" type="ORF">CELE_Y71G12B.6</name>
        <name evidence="3" type="ORF">Y71G12B.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293437.1">
        <property type="nucleotide sequence ID" value="NM_001306508.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RS16"/>
    <dbReference type="SMR" id="W6RS16"/>
    <dbReference type="PeptideAtlas" id="W6RS16"/>
    <dbReference type="GeneID" id="171744"/>
    <dbReference type="KEGG" id="cel:CELE_Y71G12B.6"/>
    <dbReference type="AGR" id="WB:WBGene00022146"/>
    <dbReference type="CTD" id="171744"/>
    <dbReference type="WormBase" id="Y71G12B.6b">
        <property type="protein sequence ID" value="CE49584"/>
        <property type="gene ID" value="WBGene00022146"/>
        <property type="gene designation" value="rml-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_641303_0_0_1"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022146">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RS16">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM63577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y71G12B.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="W6RS16"/>
        </source>
    </evidence>
    <sequence length="80" mass="8905" checksum="4168E155AABEAB75" modified="2014-04-16" version="1">MATNLYFPWLLASIAEKFSLHFTHFGNTSMSQESSALAVKGYTGKMLEYFEKTLIIGQKIDKNVLESIKACKTGGLNNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6RS18</accession>
    <name>W6RS18_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase FkbM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y71G12B.18</name>
        <name evidence="2 4" type="ORF">Y71G12B.18</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293442.1">
        <property type="nucleotide sequence ID" value="NM_001306513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RS18"/>
    <dbReference type="GeneID" id="171729"/>
    <dbReference type="KEGG" id="cel:CELE_Y71G12B.18"/>
    <dbReference type="AGR" id="WB:WBGene00022156"/>
    <dbReference type="CTD" id="171729"/>
    <dbReference type="WormBase" id="Y71G12B.18b">
        <property type="protein sequence ID" value="CE49605"/>
        <property type="gene ID" value="WBGene00022156"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054633_2_0_1"/>
    <dbReference type="OrthoDB" id="5775722at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022156">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RS18">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989:SF9">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989">
        <property type="entry name" value="UNCHARACTERIZED DUF13 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="15"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM63582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y71G12B.18b"/>
        </source>
    </evidence>
    <sequence length="256" mass="29710" checksum="5B9D3C47363F2113" modified="2014-04-16" version="1">MTHKVFNETDHKLFWAKFQIWTDECDRNAEIEQLNLVPLRNSDEIKFGLLPVESDLLGSSSNLVTLGIGKDIDAELLYKQKMNDIGRNLTFYGADPITDVNADLYSRIGKYFPFAVGGDAGYSTASVYVNGTYKNQDVVHVDLIYFFDRILKIKTYDNIWLDAEGAEYPLFDIFQSTGRLDRKGIKFCQMSLEVHSPSEPQQIQFMELIKQIVREERYGMHNNRNVGHMRMYLFNFGDSYCVKKFLMRNLYELVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BTQ8</accession>
    <name>A0A078BTQ8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">lgc-19</name>
        <name evidence="2" type="ORF">CELE_Y105C5B.16</name>
        <name evidence="4" type="ORF">Y105C5B.16</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294122.1">
        <property type="nucleotide sequence ID" value="NM_001307193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTQ8"/>
    <dbReference type="GeneID" id="190895"/>
    <dbReference type="KEGG" id="cel:CELE_Y105C5B.16"/>
    <dbReference type="AGR" id="WB:WBGene00013655"/>
    <dbReference type="CTD" id="190895"/>
    <dbReference type="WormBase" id="Y105C5B.16b">
        <property type="protein sequence ID" value="CE50087"/>
        <property type="gene ID" value="WBGene00013655"/>
        <property type="gene designation" value="lgc-19"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5866477at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013655">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTQ8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y105C5B.16b"/>
        </source>
    </evidence>
    <sequence length="102" mass="11489" checksum="3902BD37569D18E5" modified="2014-10-29" version="1">MTMTFILGVMADKIPRTGNIPLLGIYIIINLVIMLIAIAIVTAITELRKWASPKLRKKKTALRAQLESFLGRPLEYTSAIILELMTCANFLVMVGFWFEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BTR2</accession>
    <name>A0A078BTR2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CELE_Y105C5B.25</name>
        <name evidence="9 11" type="ORF">Y105C5B.25</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294127.1">
        <property type="nucleotide sequence ID" value="NM_001307198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTR2"/>
    <dbReference type="GeneID" id="190901"/>
    <dbReference type="KEGG" id="cel:CELE_Y105C5B.25"/>
    <dbReference type="AGR" id="WB:WBGene00013662"/>
    <dbReference type="CTD" id="190901"/>
    <dbReference type="WormBase" id="Y105C5B.25b">
        <property type="protein sequence ID" value="CE50004"/>
        <property type="gene ID" value="WBGene00013662"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841543at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013662">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTR2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF84">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDX47508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y105C5B.25b"/>
        </source>
    </evidence>
    <sequence length="387" mass="45096" checksum="966C616F5E701E3C" modified="2014-10-29" version="1">MHFHTQFIFFLLVVFALASYFIFVEEIDNSDVTILNSTYQCHIQPWNFVNTQSTDTSYLNRFSKWLWIKFYLPVENLHNNTEISILAAYVYPDHISITLITQHSIKKQLYCRYYDCKRNEIRGSAWLGTVFPESVIQCPRRIGAEFVSVSENLEKESDITPVGLTFRVFEEPIHELSVCVAPMYGNEPSWLPIIDFVEHNKLEGASYFYFYVGEIRDYDQKILDDYVRTGDIELVKLQDKYHRVFIAWHLLQIQDCHLRSAYHSKWTAFIDLDERLSTNGPGTMIDVLRSIQDSSVGEVQLQSTTIVKDQDYPDKYENIEQLEQELIFKKYNETVKKTMSGTKPIIKSEKIGLMSIHQASAKYFGVKTLLLNITVASVRLRQLTAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MAY5</accession>
    <name>A0A131MAY5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lin-42</name>
        <name evidence="5" type="ORF">CELE_F47F6.1</name>
        <name evidence="7" type="ORF">F47F6.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309559.1">
        <property type="nucleotide sequence ID" value="NM_001322704.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MAY5"/>
    <dbReference type="SMR" id="A0A131MAY5"/>
    <dbReference type="GeneID" id="173503"/>
    <dbReference type="AGR" id="WB:WBGene00018572"/>
    <dbReference type="CTD" id="173503"/>
    <dbReference type="WormBase" id="F47F6.1d">
        <property type="protein sequence ID" value="CE51377"/>
        <property type="gene ID" value="WBGene00018572"/>
        <property type="gene designation" value="lin-42"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7788983at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018572">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MAY5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050760">
        <property type="entry name" value="Period_circadian_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269:SF16">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="212"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
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            <end position="507"/>
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        <location>
            <begin position="612"/>
            <end position="654"/>
        </location>
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        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
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            <begin position="544"/>
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    </feature>
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            <begin position="618"/>
            <end position="634"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00091"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CZR14475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PeptideAtlas" id="A0A131MAY5"/>
        </source>
    </evidence>
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</entry>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome IV"/>
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    <dbReference type="Bgee" id="WBGene00000674">
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF423">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="170"/>
            <end position="427"/>
        </location>
    </feature>
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        <location>
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            <end position="626"/>
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        <location>
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        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
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        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="328"/>
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        <location>
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        <location>
            <begin position="408"/>
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        <location>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBA1</accession>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">Bristol N2</strain>
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        <subcellularLocation>
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        <property type="gene ID" value="WBGene00000092"/>
        <property type="gene designation" value="ags-3"/>
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        <property type="component" value="Chromosome X"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
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            <end position="72"/>
        </location>
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            <end position="101"/>
        </location>
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            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CZR14620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F32A6.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
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</entry>
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    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="172256"/>
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    <dbReference type="CTD" id="172256"/>
    <dbReference type="WormBase" id="F33D11.9c">
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        <property type="gene ID" value="WBGene00018006"/>
        <property type="gene designation" value="gpaa-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018006">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBA2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04114">
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    </dbReference>
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    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="59"/>
        </location>
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        <location>
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            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="612"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CZR14436.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBA2"/>
        </source>
    </evidence>
    <sequence length="623" mass="70297" checksum="395D51A75ADF4254" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBA3</accession>
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        <submittedName>
            <fullName evidence="2">Seven TM Receptor</fullName>
        </submittedName>
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        <name evidence="2 4" type="primary">str-10</name>
        <name evidence="2" type="ORF">CELE_R03G8.5</name>
        <name evidence="4" type="ORF">R03G8.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
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    </dbReference>
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    </dbReference>
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    <dbReference type="CTD" id="187547"/>
    <dbReference type="WormBase" id="R03G8.5b">
        <property type="protein sequence ID" value="CE51348"/>
        <property type="gene ID" value="WBGene00006078"/>
        <property type="gene designation" value="str-10"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5819992at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46000:SF7">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46000">
        <property type="entry name" value="SEVEN TM RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R03G8.5b"/>
        </source>
    </evidence>
    <sequence length="344" mass="39886" checksum="05E712D64C515022" modified="2016-05-11" version="1">MSTDYLEWISISYIIVLVGFAATLIFGLLLIILNIFCVRGVFITYRILMITFTCSGILFSTFEVVFNPNMFSYNSGTIYFTLSKPFGFGKDVLTVSLVVYTGLYSATTCLIAIQFIYRYWAVFDETKLRLFHGWHISIWIIYVLYFGMQWAIGAYNFVKTDQVAKDFFREEIMLRFNASIDDLPALSLVAFDPSNGSIRWWNVMTIVNMSFIMSIQYGIIIYCGWSMYSKMEEKIKNYSIVLQKHHNQLFKTLVLQIIAPTVFLLTPLSFIIYLPFFNIKCSLPTGVLLSLFTLYPTADSVVVIYVVTEYRQKLKHCFITTLKNIRCWKNNQINVQGTTQTRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBW3</accession>
    <name>A0A131MBW3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7 9" type="primary">dmsr-14</name>
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    </gene>
    <organism evidence="7 8">
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="AlphaFoldDB" id="A0A131MBW3"/>
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    <dbReference type="AGR" id="WB:WBGene00020523"/>
    <dbReference type="CTD" id="188521"/>
    <dbReference type="WormBase" id="T15B7.11b">
        <property type="protein sequence ID" value="CE51508"/>
        <property type="gene ID" value="WBGene00020523"/>
        <property type="gene designation" value="dmsr-14"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5836747at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBW3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47419">
        <property type="entry name" value="DROMYOSUPPRESSIN RECEPTOR RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47419:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
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    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CZR14574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="T15B7.11b"/>
        </source>
    </evidence>
    <sequence length="291" mass="33197" checksum="FE77CAE9C94EF983" modified="2016-05-11" version="1">MLSHKEMRHSGINVIMMFIAVSDFGCAVTGLMQLFIRNYSDQYMLFITAYLQLFVDYLAVVFHASSLFLAAGMALCRVMALNFSNRLKDKWQSPRYALRVTCAVYITVLTVSTLIVPVNEVKKTDDGEVYIDTSDFSLAYGCLLMKIVLVFVGICFKLIPCTLMLILSILLLQKMDEGKRSSVPINRNHKKDQLDRSSQLIQTILIVFLITEVPQGVFSIIGGIEVIDYLNYYQNLTIFMNVLSFFNTTTSFIIYSSLSAKFRRIFAQTFLPKNLLNMYMVTVAHFSKINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBW5</accession>
    <name>A0A131MBW5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">ags-3</name>
        <name evidence="10" type="ORF">CELE_F32A6.4</name>
        <name evidence="12" type="ORF">F32A6.4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CZR14618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309690.1">
        <property type="nucleotide sequence ID" value="NM_001322619.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBW5"/>
    <dbReference type="GeneID" id="180801"/>
    <dbReference type="AGR" id="WB:WBGene00000092"/>
    <dbReference type="CTD" id="180801"/>
    <dbReference type="WormBase" id="F32A6.4e">
        <property type="protein sequence ID" value="CE51275"/>
        <property type="gene ID" value="WBGene00000092"/>
        <property type="gene designation" value="ags-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000092">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBW5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF1">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CZR14618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F32A6.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBW5"/>
        </source>
    </evidence>
    <sequence length="313" mass="35943" checksum="17D488C637082197" modified="2016-05-11" version="1">MAYSLANALYIGKEVQKAITYFQRHLKIARSLEDISGQLRSYYSLALSFNNLCERRKALYFLVLAKRSSLQVNDTSALTDIDNLLNEILEAGQEDVLVDDIELIIDESADPAPADIEHRELRLTYFQKRNIHDKPVNTPEDPLAEDRYEKEEFFDMLAKLQSKRMNDQRVDASVLSSNLDFRVRQVDTEPDNSSTDGSEVLIDLLLNAQGRRMDDQRAPFLPGLNPNGQIILRRLNTDPGNEELDEHLVEWLMRVQGERLDEQRSELPPIKPEGQEEVDKKKEEDVTAIVMRMQAGRLEDQRAHLPNIPTSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBX3</accession>
    <name>A0A131MBX3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class BC (Class B-like)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srbc-67</name>
        <name evidence="2" type="ORF">CELE_T24A6.10</name>
        <name evidence="4" type="ORF">T24A6.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309659.1">
        <property type="nucleotide sequence ID" value="NM_001322533.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBX3"/>
    <dbReference type="SMR" id="A0A131MBX3"/>
    <dbReference type="GeneID" id="188827"/>
    <dbReference type="KEGG" id="cel:CELE_T24A6.10"/>
    <dbReference type="AGR" id="WB:WBGene00020749"/>
    <dbReference type="CTD" id="188827"/>
    <dbReference type="WormBase" id="T24A6.10d">
        <property type="protein sequence ID" value="CE51390"/>
        <property type="gene ID" value="WBGene00020749"/>
        <property type="gene designation" value="srbc-67"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBX3">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019420">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srbc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46418:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46418">
        <property type="entry name" value="SRBC-64-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10316">
        <property type="entry name" value="7TM_GPCR_Srbc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T24A6.10d"/>
        </source>
    </evidence>
    <sequence length="253" mass="29089" checksum="AD35E25CC478193E" modified="2016-05-11" version="1">MTAFLIPSILTTIVICQINIFLNSSLLFTIFCLKGITSKSDMSLVYSRFAADIGYSCSIIVFKLYVLAGMISKTFILKNIIFFVIRATVILGIIRTSLLFIISLDRIIALFSSQFYNPNRRKLPLSVIFLIISSSIAFDHFIMFGYCENVIDTPIDCDSARCCYNACYAHFWISREQVMFCCIVMMTVLLSLKLVVCTYFTHNQHARILSRAVRYSTTLPFYDDFFLNKKKPTKNCIVFLSMTIEEQNEFFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBX4</accession>
    <name>A0A131MBX4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">catp-5</name>
        <name evidence="17" type="ORF">CELE_K07E3.7</name>
        <name evidence="19" type="ORF">K07E3.7</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CZR14628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309699.1">
        <property type="nucleotide sequence ID" value="NM_001322625.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBX4"/>
    <dbReference type="SMR" id="A0A131MBX4"/>
    <dbReference type="GeneID" id="181067"/>
    <dbReference type="KEGG" id="cel:CELE_K07E3.7"/>
    <dbReference type="AGR" id="WB:WBGene00019493"/>
    <dbReference type="CTD" id="181067"/>
    <dbReference type="WormBase" id="K07E3.7c">
        <property type="protein sequence ID" value="CE51255"/>
        <property type="gene ID" value="WBGene00019493"/>
        <property type="gene designation" value="catp-5"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="C54A12.2a"/>
        </source>
    </evidence>
    <sequence length="328" mass="38982" checksum="3D995C7B4081A40D" modified="2016-05-11" version="1">MMDSMDFHRIMAFVYLPTILIGLLGNLLSLYAYSRKNRKSMVGFLLYSLSVSDIFLLVFALPLFSIMYLPIWTDEQRSFVVAYTAKYVYPLCMMAKTCSLYIMVLITIERWIAVCRPLEVQIWCRYTTSSYSIAAIITFAVVLNFARFFEFEIEYIDGLAFFRRDLLDSEKHWWYFMFYFIIISIIFDYLVPFVIMFVANMLIISELRRTKKERSLMTIQQQKEQNTTVMLLVITIFFGFCHFFSMALKLAESFVGKFLTIQNIYLEMLGEIFNYLIIIHTASTFFIYYMFSEKFRQIIKGIWKPDQYRHGSLPDGTLNITDRYQKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9MH54</accession>
    <name>A0A8D9MH54_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">gid-1</name>
        <name evidence="1" type="ORF">CELE_Y54E5A.7</name>
        <name evidence="3" type="ORF">Y54E5A.7</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAG8860233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001382716.1">
        <property type="nucleotide sequence ID" value="NM_001395800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9MH54"/>
    <dbReference type="GeneID" id="173332"/>
    <dbReference type="AGR" id="WB:WBGene00013202"/>
    <dbReference type="CTD" id="173332"/>
    <dbReference type="WormBase" id="Y54E5A.7e">
        <property type="protein sequence ID" value="CE54382"/>
        <property type="gene ID" value="WBGene00013202"/>
        <property type="gene designation" value="gid-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5809049at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG8860233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y54E5A.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8D9MH54"/>
        </source>
    </evidence>
    <sequence length="198" mass="22954" checksum="5FF9284FDF19D5FA" modified="2022-01-19" version="1">MLHIDGVSMPTKMFVELEKSGQYRKLNYILKMGREIMKVAGEMRGNIAPEARKVVEIATSMVSSPERPAKHPLSFALRRFIANSVVDMICYYVHHKREGKSTKRPRGTSTGEIPGSSSLRMFSELRNLFTGWKGLHIDYSTNDKKMAGIHFVRKMILEEPNFNEKEIIYTDEPMELAHERPDPPPREIIRQQRNEFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9MH60</accession>
    <name>A0A8D9MH60_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_H10E21.1</name>
        <name evidence="3 5" type="ORF">H10E21.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAG8860248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9MH60"/>
    <dbReference type="SMR" id="A0A8D9MH60"/>
    <dbReference type="AGR" id="WB:WBGene00019182"/>
    <dbReference type="WormBase" id="H10E21.1c">
        <property type="protein sequence ID" value="CE54391"/>
        <property type="gene ID" value="WBGene00019182"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5834869at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG8860248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="H10E21.1c"/>
        </source>
    </evidence>
    <sequence length="161" mass="19265" checksum="540420CCAF721FFE" modified="2022-01-19" version="1">MRRSKKSVSKLLSNQERMAQYYSRESSSEHSSLEKLQPDEIKNRRITGPSKGRRSNSGSDHSSDWKVLNLAFQEMAHYPLLMQLNEQLMEISRQLNSVETTNALQLKVIMHLLNRVSKRRTTWTQSICRFFRNFQFFFFAFSWPFIARLLYISYLKMMRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9MH66</accession>
    <name>A0A8D9MH66_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-Gid-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">gid-2</name>
        <name evidence="8" type="ORF">CELE_T07D1.2</name>
        <name evidence="10" type="ORF">T07D1.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAG8860263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001382746.1">
        <property type="nucleotide sequence ID" value="NM_001395784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9MH66"/>
    <dbReference type="SMR" id="A0A8D9MH66"/>
    <dbReference type="GeneID" id="180548"/>
    <dbReference type="AGR" id="WB:WBGene00020301"/>
    <dbReference type="CTD" id="180548"/>
    <dbReference type="WormBase" id="T07D1.2c">
        <property type="protein sequence ID" value="CE54357"/>
        <property type="gene ID" value="WBGene00020301"/>
        <property type="gene designation" value="gid-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-Gid-type" evidence="7">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="6">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG8860263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="T07D1.2c"/>
        </source>
    </evidence>
    <sequence length="165" mass="19298" checksum="BCE015F15EA5B589" modified="2022-01-19" version="1">MIDIRYKYLFDFTNREILTLKMASFFIPYEAPLKNLMRFGMHAMIQLGDLFPVGFAPAAIDDNELPIEIGFHATHSSFTCPILKEQCDAENPPMRLICGHVISKDAINRLTTSIRQQRNSSRLSKFKCPYCPREQLLENTRQVDFLKWCESDYTDEEVQLFQFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4Q9R2</accession>
    <name>A0A8S4Q9R2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">igcm-3</name>
        <name evidence="9" type="ORF">CELE_T02C5.3</name>
        <name evidence="11" type="ORF">T02C5.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAH2193561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001391195.1">
        <property type="nucleotide sequence ID" value="NM_001404197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4Q9R2"/>
    <dbReference type="GeneID" id="180569"/>
    <dbReference type="AGR" id="WB:WBGene00020160"/>
    <dbReference type="CTD" id="180569"/>
    <dbReference type="WormBase" id="T02C5.3d">
        <property type="protein sequence ID" value="CE54470"/>
        <property type="gene ID" value="WBGene00020160"/>
        <property type="gene designation" value="igcm-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6107927at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277:SF108">
        <property type="entry name" value="FASCICLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
        <property type="entry name" value="NECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="97"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="220"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH2193561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="T02C5.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4Q9R2"/>
        </source>
    </evidence>
    <sequence length="542" mass="59697" checksum="6CC9026336A97D5B" modified="2022-10-12" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-10-25" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8WHP8-2</accession>
    <name>PLIN1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform a of Perilipin-1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Lipid droplet-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">plin-1</name>
        <name evidence="1 7" type="synonym">mdt-28</name>
        <name evidence="7" type="ORF">W01A8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="Biochim. Biophys. Acta" volume="1851" first="1337" last="1345">
            <title>Lipidomic and proteomic analysis of Caenorhabditis elegans lipid droplets and identification of ACS-4 as a lipid droplet-associated protein.</title>
            <authorList>
                <person name="Vrablik T.L."/>
                <person name="Petyuk V.A."/>
                <person name="Larson E.M."/>
                <person name="Smith R.D."/>
                <person name="Watts J.L."/>
            </authorList>
            <dbReference type="PubMed" id="26121959"/>
            <dbReference type="DOI" id="10.1016/j.bbalip.2015.06.004"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2015" name="Biochim. Biophys. Acta" volume="1853" first="2481" last="2491">
            <title>Identification of lipid droplet structure-like/resident proteins in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Na H."/>
                <person name="Zhang P."/>
                <person name="Chen Y."/>
                <person name="Zhu X."/>
                <person name="Liu Y."/>
                <person name="Liu Y."/>
                <person name="Xie K."/>
                <person name="Xu N."/>
                <person name="Yang F."/>
                <person name="Yu Y."/>
                <person name="Cichello S."/>
                <person name="Mak H.Y."/>
                <person name="Wang M.C."/>
                <person name="Zhang H."/>
                <person name="Liu P."/>
            </authorList>
            <dbReference type="PubMed" id="26025681"/>
            <dbReference type="DOI" id="10.1016/j.bbamcr.2015.05.020"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2015" name="PeerJ" volume="3" first="E1213" last="E1213">
            <title>Perilipin-related protein regulates lipid metabolism in C. elegans.</title>
            <authorList>
                <person name="Chughtai A.A."/>
                <person name="Kassak F."/>
                <person name="Kostrouchova M."/>
                <person name="Novotny J.P."/>
                <person name="Krause M.W."/>
                <person name="Saudek V."/>
                <person name="Kostrouch Z."/>
                <person name="Kostrouchova M."/>
            </authorList>
            <dbReference type="PubMed" id="26357594"/>
            <dbReference type="DOI" id="10.7717/peerj.1213"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A8WHP8-1</id>
            <name evidence="7">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A8WHP8-3</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_059202 VSP_059204 VSP_059203"/>
        </isoform>
        <isoform>
            <id>A8WHP8-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_059202"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021646.1">
        <property type="nucleotide sequence ID" value="NM_001026475.4"/>
    </dbReference>
    <dbReference type="WormBase" id="W01A8.1a">
        <property type="protein sequence ID" value="CE18303"/>
        <property type="gene ID" value="WBGene00007024"/>
        <property type="gene designation" value="plin-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="26025681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="26357594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="W01A8.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="W01A8.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="W01A8.1c"/>
        </source>
    </evidence>
    <sequence length="415" mass="46135" checksum="0D28EF51E006ED73" modified="2008-01-15" version="1">MTDVEQPVSVEDQQAQAQSYYDQVLGNAYVQTAINAYTKTKEFHPLLNSTLNSAEEKVSTVGNYAAQKAYDGYNSYYVKPKNTAYEAVSYGTERAKTAVESGKQAAIVGGTFGIGAAVVLTQFSLALSAGGAALVLEQVDSAKKLGSSAISTIKEAELAVEHRIFSALHQAQRIAMVPVEKITENTNSLLDILDGAVQKGLNIEVPPSVNLTIGQRVKNLASLIVQGVSNKAHDHVIDPINERARNYLEQLSQSFVLLDIVREKKTWVIEKSNELSTSVFDFKKTLEEEAQKYKVAPEEMLMKHIQSTSEQLSTQLQSLREKGQNVFGDGTKIDSTIDYLENLKKNFTDAEDVYKVRDEVLNEGRQRIAELSTWTTSLLIISAEWQFEPEDLLIEELYFDAPPPVRTRNLYRNRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-10-25" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8WHP8-3</accession>
    <name>PLIN1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform b of Perilipin-1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Lipid droplet-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">plin-1</name>
        <name evidence="1 7" type="synonym">mdt-28</name>
        <name evidence="7" type="ORF">W01A8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="Biochim. Biophys. Acta" volume="1851" first="1337" last="1345">
            <title>Lipidomic and proteomic analysis of Caenorhabditis elegans lipid droplets and identification of ACS-4 as a lipid droplet-associated protein.</title>
            <authorList>
                <person name="Vrablik T.L."/>
                <person name="Petyuk V.A."/>
                <person name="Larson E.M."/>
                <person name="Smith R.D."/>
                <person name="Watts J.L."/>
            </authorList>
            <dbReference type="PubMed" id="26121959"/>
            <dbReference type="DOI" id="10.1016/j.bbalip.2015.06.004"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2015" name="Biochim. Biophys. Acta" volume="1853" first="2481" last="2491">
            <title>Identification of lipid droplet structure-like/resident proteins in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Na H."/>
                <person name="Zhang P."/>
                <person name="Chen Y."/>
                <person name="Zhu X."/>
                <person name="Liu Y."/>
                <person name="Liu Y."/>
                <person name="Xie K."/>
                <person name="Xu N."/>
                <person name="Yang F."/>
                <person name="Yu Y."/>
                <person name="Cichello S."/>
                <person name="Mak H.Y."/>
                <person name="Wang M.C."/>
                <person name="Zhang H."/>
                <person name="Liu P."/>
            </authorList>
            <dbReference type="PubMed" id="26025681"/>
            <dbReference type="DOI" id="10.1016/j.bbamcr.2015.05.020"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2015" name="PeerJ" volume="3" first="E1213" last="E1213">
            <title>Perilipin-related protein regulates lipid metabolism in C. elegans.</title>
            <authorList>
                <person name="Chughtai A.A."/>
                <person name="Kassak F."/>
                <person name="Kostrouchova M."/>
                <person name="Novotny J.P."/>
                <person name="Krause M.W."/>
                <person name="Saudek V."/>
                <person name="Kostrouch Z."/>
                <person name="Kostrouchova M."/>
            </authorList>
            <dbReference type="PubMed" id="26357594"/>
            <dbReference type="DOI" id="10.7717/peerj.1213"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A8WHP8-3</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_059202 VSP_059203 VSP_059204"/>
        </isoform>
        <isoform>
            <id>A8WHP8-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_059202"/>
        </isoform>
        <isoform>
            <id>A8WHP8-1</id>
            <name evidence="7">c</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021647.1">
        <property type="nucleotide sequence ID" value="NM_001026476.5"/>
    </dbReference>
    <dbReference type="WormBase" id="W01A8.1b">
        <property type="protein sequence ID" value="CE06531"/>
        <property type="gene ID" value="WBGene00007024"/>
        <property type="gene designation" value="plin-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="26025681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="26357594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="W01A8.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="W01A8.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="W01A8.1c"/>
        </source>
    </evidence>
    <sequence length="385" mass="42532" checksum="9CCE1E2B17A7247B" modified="2008-01-15" version="1">MTDVEQPVSVEDQQAQAQSYYDQVLGNAYVQTAINAYTKTKEFHPLLNSTLNSAEEKVSTVGNYAAQKAYDGYNSYYVKPKNTAYEAVSYGTERAKTAVESGKQAAIVGGTFGIGAAVVLTQFSLALSAGGAALVLEQVDSAKKLGSSAISTIKEAELAVEHRIFSALHQAQRIAMVPVEKITENTNSLLDILDGAVQKGLNIEVPPSVNLTIGQRVKNLASLIVQGVSNKAHDHVIDPINERARNYLEQLSQSFVLLDIVREKKTWVIEKSNELSTSVFDFKKTLEEEAQKYKVAPEEMLMKHIQSTSEQLSTQLQSLREKGQNVFGDGTKIDSTIDYLENLKKNFTDAEDVYKVRDEVLNEGRQRIAELSTWTTSLLVRQQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-25" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>B6EU61</accession>
    <name>B6EU61_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">glb-3</name>
        <name evidence="8" type="ORF">C06H2.5</name>
        <name evidence="6" type="ORF">CELE_C06H2.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAR81336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367199.1">
        <property type="nucleotide sequence ID" value="NM_001380758.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B6EU61"/>
    <dbReference type="SMR" id="B6EU61"/>
    <dbReference type="PeptideAtlas" id="B6EU61"/>
    <dbReference type="GeneID" id="182348"/>
    <dbReference type="AGR" id="WB:WBGene00007389"/>
    <dbReference type="CTD" id="182348"/>
    <dbReference type="WormBase" id="C06H2.5a">
        <property type="protein sequence ID" value="CE43048"/>
        <property type="gene ID" value="WBGene00007389"/>
        <property type="gene designation" value="glb-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092561_0_0_1"/>
    <dbReference type="OrthoDB" id="5850868at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007389">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B6EU61">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF21">
        <property type="entry name" value="GLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="33"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAR81336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="C06H2.5a"/>
        </source>
    </evidence>
    <sequence length="210" mass="23547" checksum="7BD8FB7FF6E817D6" modified="2008-11-25" version="1">MGNNVPSRRMSRATVHLENSNGADNMSFVDAIHLSPHQVQLLTSTWPRIKTQSSLFTQVFKVLMQRSPVCREMFQKMSIVGGFSSNSVCDLNSHTKLLCELLDSLMTDLHQPAKIVLAKCQDVGAAHVNMNEKCCGVVFDQLGEAFTELITKVECVRSKREAVKSWMCVISYMADSIKSGYMEEWAKKRRSNNHHQPQQYQAAGGSCPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLH2</accession>
    <name>H2FLH2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26 28" type="primary">unc-22</name>
        <name evidence="26" type="ORF">CELE_ZK617.1</name>
        <name evidence="28" type="ORF">ZK617.1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">A band</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCF23388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255601.1">
        <property type="nucleotide sequence ID" value="NM_001268672.3"/>
    </dbReference>
    <dbReference type="SMR" id="H2FLH2"/>
    <dbReference type="PeptideAtlas" id="H2FLH2"/>
    <dbReference type="GeneID" id="178135"/>
    <dbReference type="AGR" id="WB:WBGene00006759"/>
    <dbReference type="CTD" id="178135"/>
    <dbReference type="WormBase" id="ZK617.1f">
        <property type="protein sequence ID" value="CE46948"/>
        <property type="gene ID" value="WBGene00006759"/>
        <property type="gene designation" value="unc-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006759">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLH2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd05748">
        <property type="entry name" value="Ig_Titin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20949">
        <property type="entry name" value="IgI_Twitchin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14114">
        <property type="entry name" value="STKc_Twitchin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000321">
        <property type="entry name" value="Bent, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000440">
        <property type="entry name" value="Bent, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001845">
        <property type="entry name" value="Bent, isoform H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000460">
        <property type="entry name" value="Bent, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000504">
        <property type="entry name" value="Bent, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000147">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002083">
        <property type="entry name" value="Protein CBR-UNC-22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000160">
        <property type="entry name" value="Titin a"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000003">
        <property type="entry name" value="Titin isoform E"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000127">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001003">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002226">
        <property type="entry name" value="Twitchin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002229">
        <property type="entry name" value="Twitchin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002276">
        <property type="entry name" value="Twitchin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002441">
        <property type="entry name" value="Twitchin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000249">
        <property type="entry name" value="twitchin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000056">
        <property type="entry name" value="twitchin isoform X4"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000831">
        <property type="entry name" value="Uncharacterized protein, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000567">
        <property type="entry name" value="Uncharacterized protein, isoform G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000051">
        <property type="entry name" value="Uncharacterized protein, isoform J"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="61"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF151">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="16" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="111"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="377"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="749"/>
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    <sequence length="6927" mass="763470" checksum="9671874AC5929A05" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLH3</accession>
    <name>H2FLH3_CAEEL</name>
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        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
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        <name evidence="26 28" type="primary">unc-22</name>
        <name evidence="26" type="ORF">CELE_ZK617.1</name>
        <name evidence="28" type="ORF">ZK617.1</name>
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    <organism evidence="26 27">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Bristol N2</strain>
        </source>
    </reference>
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        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
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            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
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            <dbReference type="ChEBI" id="CHEBI:30013"/>
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            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">A band</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF23389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001268673.3"/>
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        <property type="protein sequence ID" value="CE46868"/>
        <property type="gene ID" value="WBGene00006759"/>
        <property type="gene designation" value="unc-22"/>
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        <property type="component" value="Chromosome IV"/>
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        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
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        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:enzyme binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of locomotion"/>
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            <begin position="1052"/>
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</entry>
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</entry>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="195"/>
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</entry>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="Octopmn_rcpt"/>
    </dbReference>
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        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24248:SF174">
        <property type="entry name" value="TYRAMINE_OCTOPAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="OCTOPAMINER"/>
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        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="7 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="74"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF23384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="C02D4.2g"/>
        </source>
    </evidence>
    <sequence length="420" mass="47012" checksum="F54B9E7DAE50A90F" modified="2012-03-21" version="1">MFRNYTDSVQEMVLRAIDSIRDSVINASSAVSTTTLPPLDIPMTSMKPPSIIPTVELVLGTITYLVIIAMTVVGNTLVVVAVFSYRPLKKVQNYFLVSLAASDLAVAIFVMPLHVVTFLAGGKWLLGVTVCQFFTTADILLCTSSILNLCAIALDRYWAIHNPINYAQKRTTKFVCIVIVIVWILSMLISVPPIIGWNNWQENMMEDSCGLSTEKAFVVFSAAGSFFLPLLVMVVVYVKIFISARQRIRTNRGRSALMRIQNAEGDDDYRKMSIKRASVESARTSSRVGEKTPLVIADGQTTVTTLAAHSNPNPTAVLRKREKISVAKEKRAAKTIAVIIFVFSFCWLPFFVAYVIRPFCETCKLHAKVEQAFTWLGYINSSLNPFLYGILNLEFRRAFKKILCPKAVLEQRRRRMSAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLI7</accession>
    <name>H2FLI7_CAEEL</name>
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        <submittedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rig-5</name>
        <name evidence="13" type="ORF">C36F7.4</name>
        <name evidence="11" type="ORF">CELE_C36F7.4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCF23367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001251132.1">
        <property type="nucleotide sequence ID" value="NM_001264203.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLI7"/>
    <dbReference type="SMR" id="H2FLI7"/>
    <dbReference type="GeneID" id="172791"/>
    <dbReference type="AGR" id="WB:WBGene00004372"/>
    <dbReference type="CTD" id="172791"/>
    <dbReference type="WormBase" id="C36F7.4f">
        <property type="protein sequence ID" value="CE47023"/>
        <property type="gene ID" value="WBGene00004372"/>
        <property type="gene designation" value="rig-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004372">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLI7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
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        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
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        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="33"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="139"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="236"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="338"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF23367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C36F7.4f"/>
        </source>
    </evidence>
    <sequence length="431" mass="47944" checksum="03922C81B0E3C670" modified="2012-03-21" version="1">MLVDGTPPTSSSILVLPTILCHLFDACSRGAPPTIQQPSMSSAVALLGQDVDFTCIVNDLGSHMVAFVKADSPPRLLSFDEKVFRRRNKYELKPRIGDLHNEWVLTIKNVQESDRGNYSCQINTEPITLSTGELDVKVPPVVSRSTPAAVEVREGNNVSLTCKADGNPTPTVIWRRQDRQIIRYNGATGFGASVFHGPVLHLTKVSRKHMSEYLCVASNGIPPDESWTVKLLVTFPPLVQAQSETVQASVGSMARMVCTTEAWPRPEMGWEKDGEPVYESNNVAMTHTVSGQYHSVHILEIRNVQSSHFGVYRCVAKNDNGIHHSQVTLNQISHNHFTNSNLIPEGSGMPRGYSEDDEADEEEDNLENQKNDSEEEDSQSPPQLEFYSQARRHESRNAPTTRSELRAIQVDSASFPSLLLITIIYFVYHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLI8</accession>
    <name>H2FLI8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">rig-5</name>
        <name evidence="12" type="ORF">C36F7.4</name>
        <name evidence="10" type="ORF">CELE_C36F7.4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCF23368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001251129.1">
        <property type="nucleotide sequence ID" value="NM_001264200.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLI8"/>
    <dbReference type="SMR" id="H2FLI8"/>
    <dbReference type="GeneID" id="172791"/>
    <dbReference type="AGR" id="WB:WBGene00004372"/>
    <dbReference type="CTD" id="172791"/>
    <dbReference type="WormBase" id="C36F7.4g">
        <property type="protein sequence ID" value="CE47060"/>
        <property type="gene ID" value="WBGene00004372"/>
        <property type="gene designation" value="rig-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027228_4_2_1"/>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004372">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLI8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="84"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="190"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="287"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF23368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C36F7.4g"/>
        </source>
    </evidence>
    <sequence length="424" mass="47348" checksum="93B52E257CEBB08E" modified="2012-03-21" version="1">MCVSSSFSFFSSTLFPYFSRLHLCLLFGKWTARDSALSGAPTFRGRGRFVILFHIPLQEKMYLFALLCGVLLVFKQACSRGAPPTIQQPSMSSAVALLGQDVDFTCIVNDLGSHMVAFVKADSPPRLLSFDEKVFRRRNKYELKPRIGDLHNEWVLTIKNVQESDRGNYSCQINTEPITLSTGELDVKVPPVVSRSTPAAVEVREGNNVSLTCKADGNPTPTVIWRRQDRQIIRYNGATGFGASVFHGPVLHLTKVSRKHMSEYLCVASNGIPPDESWTVKLLVTFPPLVQAQSETVQASVGSMARMVCTTEAWPRPEMGWEKDGEPVYESNNVAMTHTVSGQYHSVHILEIRNVQSSHFGVYRCVAKNDNGIHHSQVTLNQISHNHFTNSNLIPEELRAIQVDSASFPSLLLITIIYFVYHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLI9</accession>
    <name>H2FLI9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_F11F1.1</name>
        <name evidence="7 9" type="ORF">F11F1.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCF23417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255200.1">
        <property type="nucleotide sequence ID" value="NM_001268271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLI9"/>
    <dbReference type="SMR" id="H2FLI9"/>
    <dbReference type="GeneID" id="3565569"/>
    <dbReference type="AGR" id="WB:WBGene00008714"/>
    <dbReference type="CTD" id="3565569"/>
    <dbReference type="WormBase" id="F11F1.1b">
        <property type="protein sequence ID" value="CE47058"/>
        <property type="gene ID" value="WBGene00008714"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_1_1"/>
    <dbReference type="OrthoDB" id="5788289at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008714">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLI9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd24028">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000046">
        <property type="entry name" value="Chaperone protein HscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003677">
        <property type="entry name" value="ANIS5_cation-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02520">
        <property type="entry name" value="ANIS5_cation-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SXP/RAL-2 family protein Ani s 5-like cation-binding" evidence="6">
        <location>
            <begin position="443"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF23417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F11F1.1b"/>
        </source>
    </evidence>
    <sequence length="567" mass="62466" checksum="470E687F303EB323" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLJ3</accession>
    <name>H2FLJ3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_K07A12.8</name>
        <name evidence="2 4" type="ORF">K07A12.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCF23394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001250849.1">
        <property type="nucleotide sequence ID" value="NM_001263920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLJ3"/>
    <dbReference type="SMR" id="H2FLJ3"/>
    <dbReference type="GeneID" id="7040151"/>
    <dbReference type="KEGG" id="cel:CELE_K07A12.8"/>
    <dbReference type="AGR" id="WB:WBGene00086557"/>
    <dbReference type="CTD" id="7040151"/>
    <dbReference type="WormBase" id="K07A12.8c">
        <property type="protein sequence ID" value="CE46900"/>
        <property type="gene ID" value="WBGene00086557"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5869420at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00086557">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLJ3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF23394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K07A12.8c"/>
        </source>
    </evidence>
    <sequence length="65" mass="7298" checksum="9C735AA68D177838" modified="2012-03-21" version="1">MFNSRRVVTDNECSKLQYREEVVGVTLTKLELTLVLTMYIAAVVILVVLFELLKPSISAHLMGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLJ6</accession>
    <name>H2FLJ6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DDT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">nurf-1</name>
        <name evidence="8" type="ORF">CELE_F26H11.2</name>
        <name evidence="10" type="ORF">F26H11.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCF23403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254428.1">
        <property type="nucleotide sequence ID" value="NM_001267499.2"/>
    </dbReference>
    <dbReference type="GeneID" id="175098"/>
    <dbReference type="AGR" id="WB:WBGene00009180"/>
    <dbReference type="CTD" id="175098"/>
    <dbReference type="WormBase" id="F26H11.2k">
        <property type="protein sequence ID" value="CE46986"/>
        <property type="gene ID" value="WBGene00009180"/>
        <property type="gene designation" value="nurf-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009180">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLJ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038028">
        <property type="entry name" value="BPTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    </evidence>
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</entry>
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    <accession>H2FLK9</accession>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF23424.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="K08H10.1j"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="H2FLK9"/>
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</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="179" xmlns="https://uniprot.org/uniprot">
    <accession>O18056</accession>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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        <source>
            <strain evidence="13 14">Bristol N2</strain>
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        <reaction evidence="7">
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        <location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="9">
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAA90406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="T07D4.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="O18056"/>
        </source>
    </evidence>
    <sequence length="638" mass="69968" checksum="186AA9583E19ACBE" modified="1998-08-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="169" xmlns="https://uniprot.org/uniprot">
    <accession>O18058</accession>
    <name>O18058_CAEEL</name>
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        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5 7" type="primary">cal-4</name>
        <name evidence="5" type="ORF">CELE_T07G12.1</name>
        <name evidence="7" type="ORF">T07G12.1</name>
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    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAB05271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T24672">
        <property type="entry name" value="T24672"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255491.1">
        <property type="nucleotide sequence ID" value="NM_001268562.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O18058"/>
    <dbReference type="SMR" id="O18058"/>
    <dbReference type="GeneID" id="177945"/>
    <dbReference type="KEGG" id="cel:CELE_T07G12.1"/>
    <dbReference type="UCSC" id="T07G12.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000288"/>
    <dbReference type="CTD" id="177945"/>
    <dbReference type="WormBase" id="T07G12.1c">
        <property type="protein sequence ID" value="CE13387"/>
        <property type="gene ID" value="WBGene00000288"/>
        <property type="gene designation" value="cal-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_2_3_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="O18058"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000288">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O18058">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000238">
        <property type="entry name" value="CALmodulin related genes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000337">
        <property type="entry name" value="CALmodulin related genes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB05271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="T07G12.1c"/>
        </source>
    </evidence>
    <sequence length="182" mass="20816" checksum="4255F9A47E5EC85E" modified="1998-01-01" version="1">MYRQGTNQSVCSDADEFTPEELQEFAQAFKLFDKDGNNTMNIKELGEAMRMLGLNPTEEELLNMVNEYDVDGNGKIDFGEFCKMMKEMNKETDQELIRLAFKVFDKDGNGYITAQEFKHFMTTMGERFSEEEVDEIIREVDKDGDEQIDLDEFVNMVAPIVSDGTKTDPFLEPTASTNPPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>O18064</accession>
    <name>O18064_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="3 5" type="primary">zim-1</name>
        <name evidence="3" type="ORF">CELE_T07G12.6</name>
        <name evidence="5" type="ORF">T07G12.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAB05277.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T24678">
        <property type="entry name" value="T24678"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_501948.2">
        <property type="nucleotide sequence ID" value="NM_069547.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O18064"/>
    <dbReference type="SMR" id="O18064"/>
    <dbReference type="IntAct" id="O18064">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="3565259"/>
    <dbReference type="UCSC" id="T07G12.6">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011597"/>
    <dbReference type="CTD" id="3565259"/>
    <dbReference type="WormBase" id="T07G12.6a">
        <property type="protein sequence ID" value="CE38977"/>
        <property type="gene ID" value="WBGene00011597"/>
        <property type="gene designation" value="zim-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007005_0_0_1"/>
    <dbReference type="OrthoDB" id="5865697at2759"/>
    <dbReference type="PhylomeDB" id="O18064"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011597">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O18064">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053360">
        <property type="entry name" value="Zinc_finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36945:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36945">
        <property type="entry name" value="HIGH INCIDENCE OF MALES (INCREASED X CHROMOSOME LOSS)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB05277.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T07G12.6a"/>
        </source>
    </evidence>
    <sequence length="600" mass="67714" checksum="8D817914F338DECE" modified="2005-09-13" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>O45670</accession>
    <name>O45670_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clc-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">clc-6</name>
        <name evidence="3" type="ORF">CELE_K10D6.2</name>
        <name evidence="5" type="ORF">K10D6.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA98514.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_505843.2">
        <property type="nucleotide sequence ID" value="NM_073442.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O45670"/>
    <dbReference type="PeptideAtlas" id="O45670"/>
    <dbReference type="GeneID" id="179548"/>
    <dbReference type="UCSC" id="K10D6.2b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010742"/>
    <dbReference type="CTD" id="179548"/>
    <dbReference type="WormBase" id="K10D6.2a">
        <property type="protein sequence ID" value="CE06176"/>
        <property type="gene ID" value="WBGene00010742"/>
        <property type="gene designation" value="clc-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065659_1_0_1"/>
    <dbReference type="OrthoDB" id="5823275at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010742">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O45670">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000039">
        <property type="entry name" value="Neuronal SYmmetry"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574:SF1">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004158359" evidence="2">
        <location>
            <begin position="28"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA98514.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K10D6.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="O45670"/>
        </source>
    </evidence>
    <sequence length="269" mass="30383" checksum="B92B4C7D96A22025" modified="2011-11-16" version="3">MGSTVTQKLLLALSIVLILVGICLTSAGCFSPAWQVVDIREFRAEHQHGLWWDCIRAEKHVVSVGDFYDETPLHCMYKFDNSAELVIQNTLNNIDEDGAAGESEHHRFWAWHKAILFFIITSEFLAFISICSGVCAPCVPSTAFAFSISLFIAMLCSLLADGIFFLAANRVDNRFVQGMVGTYEQRIGYAFYLHLMGTLCWIGAFVCTLLTTYKFVTGDEEDGRNELPYRREEPLLHDKFVSSQQAGYRPNPQVPYRTTSITQYRETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>O45692</accession>
    <name>O45692_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_M01E5.3</name>
        <name evidence="3 5" type="ORF">M01E5.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0561 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB07641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T23649">
        <property type="entry name" value="T23649"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_493335.1">
        <property type="nucleotide sequence ID" value="NM_060934.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O45692"/>
    <dbReference type="IntAct" id="O45692">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="173193"/>
    <dbReference type="UCSC" id="M01E5.3c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010806"/>
    <dbReference type="CTD" id="173193"/>
    <dbReference type="WormBase" id="M01E5.3a">
        <property type="protein sequence ID" value="CE16272"/>
        <property type="gene ID" value="WBGene00010806"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_488561_0_0_1"/>
    <dbReference type="OrthoDB" id="5861529at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010806">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O45692">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018888">
        <property type="entry name" value="UPF0561"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34256">
        <property type="entry name" value="UPF0561 PROTEIN C2ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34256:SF1">
        <property type="entry name" value="UPF0561 PROTEIN C2ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB07641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="M01E5.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="O45692"/>
        </source>
    </evidence>
    <sequence length="558" mass="61018" checksum="D7C9E4F1D76EA805" modified="1998-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2026-01-28" version="185" xmlns="https://uniprot.org/uniprot">
    <accession>P17221-2</accession>
    <name>FEM1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Sex-determining protein fem-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Feminization of XX and XO animals protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">fem-1</name>
        <name type="synonym">isx-1</name>
        <name type="ORF">F35D6.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Cell" volume="60" first="981" last="990">
            <title>The product of fem-1, a nematode sex-determining gene, contains a motif found in cell cycle control proteins and receptors for cell-cell interactions.</title>
            <authorList>
                <person name="Spence A.M."/>
                <person name="Coulson A."/>
                <person name="Hodgkin J."/>
            </authorList>
            <dbReference type="PubMed" id="2317869"/>
            <dbReference type="DOI" id="10.1016/0092-8674(90)90346-G"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="J. Biol. Chem." volume="275" first="17925" last="17928">
            <title>The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells.</title>
            <authorList>
                <person name="Chan S.L."/>
                <person name="Yee K.S."/>
                <person name="Tan K.M."/>
                <person name="Yu V.C."/>
            </authorList>
            <dbReference type="PubMed" id="10764728"/>
            <dbReference type="DOI" id="10.1074/jbc.C000146200"/>
        </citation>
        <scope>INTERACTION WITH CED-4</scope>
        <scope>PROTEOLYTIC CLEAVAGE</scope>
        <scope>MUTAGENESIS OF ASP-320 AND ASP-344</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="12549" last="12554">
            <title>The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome.</title>
            <authorList>
                <person name="Jaeger S."/>
                <person name="Schwartz H.T."/>
                <person name="Horvitz H.R."/>
                <person name="Conradt B."/>
            </authorList>
            <dbReference type="PubMed" id="15306688"/>
            <dbReference type="DOI" id="10.1073/pnas.0405087101"/>
        </citation>
        <scope>INTERACTION WITH SEL-10</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Dev. Cell" volume="13" first="127" last="139">
            <title>A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination.</title>
            <authorList>
                <person name="Starostina N.G."/>
                <person name="Lim J.M."/>
                <person name="Schvarzstein M."/>
                <person name="Wells L."/>
                <person name="Spence A.M."/>
                <person name="Kipreos E.T."/>
            </authorList>
            <dbReference type="PubMed" id="17609115"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2007.05.008"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN THE CBC(FEM-1) COMPLEX</scope>
        <scope>INTERACTION WITH TRA-1; CUL-2; ELC-1; FEM-2 AND FEM-3</scope>
        <scope>MUTAGENESIS OF 541-LEU--ASP-548</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="J. Biol. Chem." volume="288" first="22058" last="22066">
            <title>Structural insight into Caenorhabditis elegans sex-determining protein FEM-2.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Zhao H."/>
                <person name="Wang J."/>
                <person name="Ge J."/>
                <person name="Li Y."/>
                <person name="Gu J."/>
                <person name="Li P."/>
                <person name="Feng Y."/>
                <person name="Yang M."/>
            </authorList>
            <dbReference type="PubMed" id="23760267"/>
            <dbReference type="DOI" id="10.1074/jbc.M113.464339"/>
        </citation>
        <scope>IDENTIFICATION IN A COMPLEX WITH FEM-2 AND FEM-3</scope>
        <scope>INTERACTION WITH FEM-2</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2017" name="Cell Cycle" volume="16" first="556" last="564">
            <title>FEM1 proteins are ancient regulators of SLBP degradation.</title>
            <authorList>
                <person name="Dankert J.F."/>
                <person name="Pagan J.K."/>
                <person name="Starostina N.G."/>
                <person name="Kipreos E.T."/>
                <person name="Pagano M."/>
            </authorList>
            <dbReference type="PubMed" id="28118078"/>
            <dbReference type="DOI" id="10.1080/15384101.2017.1284715"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2023" name="Hum. Mol. Genet." volume="32" first="1152" last="1161">
            <title>A novel de novo FEM1C variant is linked to neurodevelopmental disorder with absent speech, pyramidal signs, and limb ataxia.</title>
            <authorList>
                <person name="Dubey A.A."/>
                <person name="Krygier M."/>
                <person name="Szulc N.A."/>
                <person name="Rutkowska K."/>
                <person name="Kosinska J."/>
                <person name="Pollak A."/>
                <person name="Rydzanicz M."/>
                <person name="Kmiec T."/>
                <person name="Mazurkiewicz-Beldzinska M."/>
                <person name="Pokrzywa W."/>
                <person name="Ploski R."/>
            </authorList>
            <dbReference type="PubMed" id="36336956"/>
            <dbReference type="DOI" id="10.1093/hmg/ddac276"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ASP-133</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P17221-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_015676 VSP_015677"/>
        </isoform>
        <isoform>
            <id>P17221-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379561.1">
        <property type="nucleotide sequence ID" value="NM_001392312.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F35D6.1b">
        <property type="protein sequence ID" value="CE28299"/>
        <property type="gene ID" value="WBGene00001411"/>
        <property type="gene designation" value="fem-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="104" mass="11906" checksum="4C413AE3FC2DEB97" modified="1990-08-01" version="1">MTPNGHHFRTVIYNAAAVGNLQRIKVFTINSRNDRQWIIDCFNSDQDGRYPLVIAARNGHANVVEYLLEIGADPSVRGVVEFDNENILFRRNTSFVGCLRCWTH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>P34530-2</accession>
    <name>YM91_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Uncharacterized protein M01A8.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">M01A8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34530-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34530-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_043961"/>
        </isoform>
        <isoform>
            <id>P34530-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_043960 VSP_043959"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001254983.1">
        <property type="nucleotide sequence ID" value="NM_001268054.4"/>
    </dbReference>
    <dbReference type="WormBase" id="M01A8.1b">
        <property type="protein sequence ID" value="CE00275"/>
        <property type="gene ID" value="WBGene00010795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="203" mass="22235" checksum="B8DFB445B69D01A4" modified="2012-06-13" version="2">MCFFLLCFLDSFRNRDTTQSDTDVIYPRDDPRASRSHQNFGFMDPPPRYEQIFKRGGGTPSVITTREAPSVTRSTGDGSLPPSYEQAALNARRESRPQLPQGTLREVPLTAIDMEHPAMSTPSSTVLDMESEITNITNHAQACVHRYDASHANEVTRTAVAVTTESPAPAQSTSNALPELEAPEGGPPGYDTISLHNETVSTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>P34530-3</accession>
    <name>YM91_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Uncharacterized protein M01A8.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">M01A8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34530-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_043959 VSP_043960"/>
        </isoform>
        <isoform>
            <id>P34530-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_043961"/>
        </isoform>
        <isoform>
            <id>P34530-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001254984.1">
        <property type="nucleotide sequence ID" value="NM_001268055.3"/>
    </dbReference>
    <dbReference type="WormBase" id="M01A8.1c">
        <property type="protein sequence ID" value="CE45908"/>
        <property type="gene ID" value="WBGene00010795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="161" mass="17232" checksum="4044DF1F02BAF5A3" modified="2012-06-13" version="2">MDPPPRYEQIFKRGGGTPSVITTREAPSVTRSTGDGSLPPSYEQAALNARRESRPQLPQGTLREVPLTAIDMEHPAMSTPSSTVLDMESEITNITNHAQACVHRYDASHANEVTRTAVAVTTESPAPAQSTSNALPELEAPEGGPPGYDTISLHNETVSTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="154" xmlns="https://uniprot.org/uniprot">
    <accession>P34664-2</accession>
    <name>KCMF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of E3 ubiquitin-protein ligase kcmf-1</fullName>
            <shortName evidence="2">KCMF1 homolog</shortName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Potassium channel modulatory factor kcmf-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">kcmf-1</name>
        <name evidence="3" type="ORF">ZK652.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34664-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34664-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_017900"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9P0J7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK652.6a"/>
        </source>
    </evidence>
    <sequence length="229" mass="25367" checksum="6C93A9B860D8A118" modified="2002-06-06" version="2">MKSTAKVKEDIDDKMPVWTQRPLKRLANAAQVTTTSDSEGDPGWLPLSFETTPIRSTGCGGYWSDKRFLRPRKMQREQSVASSNAEIMEKAEIALALIRASCLHEPVFTDPTKPDIALKEALQHLRLGEKPAKMMEYQAAEELVNMPERDPITTGEMEVEIPDFTARGYGQIVDGNIPLGVVPEADEAITNSEDEEIVGGETSGDDEDEQEDDENDSQDSSVPEEINID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>P35800-2</accession>
    <name>DPY10_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Cuticle collagen dpy-10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Protein dumpy-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">dpy-10</name>
        <name type="ORF">T14B4.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Mol. Biol. Cell" volume="4" first="803" last="817">
            <title>Molecular and genetic analyses of the Caenorhabditis elegans dpy-2 and dpy-10 collagen genes: a variety of molecular alterations affect organismal morphology.</title>
            <authorList>
                <person name="Levy A.D."/>
                <person name="Yang J."/>
                <person name="Kramer J.M."/>
            </authorList>
            <dbReference type="PubMed" id="8241567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>MUTAGENESIS OF ARG-108; GLY-153; GLY-168 AND GLY-237</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P35800-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_019859 VSP_007377"/>
        </isoform>
        <isoform>
            <id>P35800-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="335" mass="33923" checksum="DC48CD437D2A6FC8" modified="2006-07-25" version="2" precursor="true">MIYRCVTGLQIGFSLFSFIIVCVALPIMYNHVQNTITYVDREMAYCERSNDEAALELQYGKMRMTGNRTARGAYGSGASHGFRPTAYGDEITGAPLETECPGCCIPGPPGPRGSSGTPGKPGLPGNAGKPGMPGTTPNQTCPLNQVREPPPCRPCPKGPPGIKGWPGFPGDVGPPGPPGLKGIDGEDGAPGETGPTGPPGYRGGPGAPGDKGPTPEGDLKEGPPGDEGPPGPIGAPGMPGLPGRNGLTGGQGERGWPGVSGESGEPGYPGPEGPMGGQGPPGEPGVCVCQNVDSILLINPGPQPRIRADDYNSDDGYGGSRGGGDRAGYQGYGRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-02-11" modified="2026-01-28" version="167" xmlns="https://uniprot.org/uniprot">
    <accession>P91406-2</accession>
    <name>GCP2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Glutamate carboxypeptidase 2 homolog</fullName>
            <ecNumber evidence="1">3.4.17.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate carboxypeptidase II homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gcp-2.1</name>
        <name evidence="2" type="ORF">R57.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-175 AND ASN-337</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P91406-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_009603 VSP_009602"/>
        </isoform>
        <isoform>
            <id>P91406-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.17.21" evidence="1"/>
    <dbReference type="RefSeq" id="NP_872248.2">
        <property type="nucleotide sequence ID" value="NM_182448.5"/>
    </dbReference>
    <dbReference type="WormBase" id="R57.1b">
        <property type="protein sequence ID" value="CE37270"/>
        <property type="gene ID" value="WBGene00020082"/>
        <property type="gene designation" value="gcp-2.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q04609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="R57.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="R57.1b"/>
        </source>
    </evidence>
    <sequence length="576" mass="63970" checksum="BFB5C9ED066732E8" modified="2004-12-21" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2026-01-28" version="154" xmlns="https://uniprot.org/uniprot">
    <accession>Q09991-2</accession>
    <name>CTS41_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Serine carboxypeptidase ctsa-4.1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Carboxypeptidase C</fullName>
            <ecNumber evidence="1">3.4.16.5</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ctsa-4.1</name>
        <name evidence="3" type="synonym">ctsa-1</name>
        <name evidence="3" type="synonym">drd-7</name>
        <name evidence="3" type="ORF">K10B2.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09991-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09991-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060208"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.16.5" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001379755.1">
        <property type="nucleotide sequence ID" value="NM_001393099.1"/>
    </dbReference>
    <dbReference type="WormBase" id="K10B2.2b">
        <property type="protein sequence ID" value="CE33418"/>
        <property type="gene ID" value="WBGene00019605"/>
        <property type="gene designation" value="ctsa-4.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="K10B2.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="K10B2.2b"/>
        </source>
    </evidence>
    <sequence length="203" mass="22814" checksum="FC192FC058984086" modified="1996-02-01" version="1" precursor="true">MYNLYDVCYYNPTTNLKKAFIERQMRIAVGLPARKHNAATTVPLCAQTNNTHVYLNRADVRKSLHIPSSLPAWEECSDQVGKNYVVTHFNVIPEFQTMIAAGIKILVYNGDVDTACNSIMNQQFLTSLNLTVLGEQEKVNEAWHYSGQTGTAVAGFQTKFAGNVDFLTVRGSGHFVPEDKPKESQQMIFNFINNKDYSTPIQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2026-01-28" version="188" xmlns="https://uniprot.org/uniprot">
    <accession>Q17771-2</accession>
    <name>NHR35_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Nuclear hormone receptor family member nhr-35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nhr-35</name>
        <name type="ORF">C07A12.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="J. Mol. Evol." volume="60" first="577" last="586">
            <title>Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes.</title>
            <authorList>
                <person name="Robinson-Rechavi M."/>
                <person name="Maina C.V."/>
                <person name="Gissendanner C.R."/>
                <person name="Laudet V."/>
                <person name="Sluder A."/>
            </authorList>
            <dbReference type="PubMed" id="15983867"/>
            <dbReference type="DOI" id="10.1007/s00239-004-0175-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 35-542 (ISOFORM A)</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q17771-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020160"/>
        </isoform>
        <isoform>
            <id>Q17771-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379629.1">
        <property type="nucleotide sequence ID" value="NM_001392764.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C07A12.3b">
        <property type="protein sequence ID" value="CE38483"/>
        <property type="gene ID" value="WBGene00003628"/>
        <property type="gene designation" value="nhr-35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="486" mass="54676" checksum="09C19A84B67260E9" modified="2004-03-15" version="3">MLGTYNGDSKAETDGKDNSICHICSDVATGRHYGAIACNGCKGFFRRTVRRNYEYHCRFESKCEIDKHNRAVCRYCRFMKCISSGMRDDQVQSERDVIGKREKKDNMKTYCQDPTPRTSPELTMSPVEDEYDQLLESLLKSEMTIQSLRDTVITQTGNVEYTTKSKNRLSHTDRTATLNDVLKSMHSQLLLVIEWAKTLPEFKQLSGADQAVLLKNFAGQHVTLCVAYRSVGANDALKLLNDLYIPRASKTTPHLKEYVDGFYLRDCEKVMDQLVEPMRFLKLDNKEFVALKACVLFNPVAPGLSNHAVNLVLNARRKIFAAFEKYVRVNKPLETTRVGDLTFFILTPLSVLSKSISEDIMFTKVSGVARIDVLMEELILAETDYGEDRQDQTPCSIMNDTPSGSQDMCSPCPEDLLRTSTSSNSPTNSSLTAGLLLKTDDAMMSGIGTQYTTPQPHTPQFADSSHLNLPYAPFTSSYNQYPNTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q18564</accession>
    <name>Q18564_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">gnrr-4</name>
        <name evidence="13" type="ORF">C41G11.4</name>
        <name evidence="11" type="ORF">CELE_C41G11.4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29514">
        <property type="entry name" value="T29514"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741798.1">
        <property type="nucleotide sequence ID" value="NM_171692.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18564"/>
    <dbReference type="GeneID" id="180841"/>
    <dbReference type="UCSC" id="C41G11.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016570"/>
    <dbReference type="CTD" id="180841"/>
    <dbReference type="WormBase" id="C41G11.4a">
        <property type="protein sequence ID" value="CE29716"/>
        <property type="gene ID" value="WBGene00016570"/>
        <property type="gene designation" value="gnrr-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023757_0_0_1"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016570">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232:SF53">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="35"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD67136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C41G11.4a"/>
        </source>
    </evidence>
    <sequence length="493" mass="56681" checksum="02A915F96066DE2E" modified="2001-12-01" version="2">MSEATQQETQRVELSFSYTLELWMYGIAFCVGLPAFIFTVVRLARSRSSRQHLVLAARLFSYKISLSVADCIVLFIYAPTQFAWIHSYWWFGGDIGCRLFKFISTFGFHLTANMQVLVAADRLLITAKMNRVTRNIKKRQYNTRLSLAAAWILALICAGPQLILFRQKTTPQGYPQCISIWTEHRVDFYDRLELLEQYAYMQHELANKSPIYFFENGTLRYAKEDFPSEPGFTLEELHTNNRNWLYLERLYNVLHLATICVIPYAMELICYTLILYILKGASKGRFVSLSDIVKDIFCCCKRARQHESPIESNVTQESDNLMARVPSKTKRLQNIAPEGKSCDMERRRAASVDVPMRIKNSSSLTVCIDENGSATAATRPEVTPQEQEPETRTQAFKRRVWNFLLDLFHNGSEARRQSAPASARSNTLWVVTVDTARRNARWKAFIMLSLNLVFWAPYCILAITSSVIISQYLTNFQFVNALVTFNAVSNIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="166" xmlns="https://uniprot.org/uniprot">
    <accession>Q18585</accession>
    <name>Q18585_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">dhhc-9</name>
        <name evidence="11" type="ORF">C43H6.7</name>
        <name evidence="9" type="ORF">CELE_C43H6.7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508435.2">
        <property type="nucleotide sequence ID" value="NM_076034.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18585"/>
    <dbReference type="SMR" id="Q18585"/>
    <dbReference type="DIP" id="DIP-24538N"/>
    <dbReference type="PaxDb" id="6239-C43H6.7"/>
    <dbReference type="PeptideAtlas" id="Q18585"/>
    <dbReference type="GeneID" id="183426"/>
    <dbReference type="UCSC" id="C43H6.7">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016620"/>
    <dbReference type="CTD" id="183426"/>
    <dbReference type="WormBase" id="C43H6.7a">
        <property type="protein sequence ID" value="CE41775"/>
        <property type="gene ID" value="WBGene00016620"/>
        <property type="gene designation" value="dhhc-9"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054274_2_0_1"/>
    <dbReference type="OMA" id="VENWRCF"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="PhylomeDB" id="Q18585"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016620">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18585">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="105"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD67187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C43H6.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="Q18585"/>
        </source>
    </evidence>
    <sequence length="311" mass="35723" checksum="C213F92860F5F413" modified="2008-01-15" version="2">MCHDKMNHFCDFIDRKIDDGTFIPMVKAANSSMRQIGKFLVFFVYFISTFLAFTSFFIIIPYEQLYKPAWLLLLLGTCGLYFLFNIQYHYYKARTIPPVANPGEEGDSFCSKCNYWKSDNAHHCSVCEKCVLGMDHHCIWINQCVGLHNHRHFFLFIANLTLAAATIIIAGYQSFSDHLFLESSQTTYCTTILEHAPLQDIICDYDGFARTSVVFCYLLSGILLVMVGGLTSWNIYLISIGCTYIDYLKLTGSKKNTSARKRLNKGFKANWRNFLGLRRNRTFFKCVIMPTALPPVKYEDISPKSDAYDIV</sequence>
</entry>
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    <accession>Q18591</accession>
    <name>Q18591_CAEEL</name>
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        <submittedName>
            <fullName evidence="20">GLutamate Receptor family (AMPA)</fullName>
        </submittedName>
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        <name evidence="22" type="ORF">C43H6.9</name>
        <name evidence="20" type="ORF">CELE_C43H6.9</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359931.1">
        <property type="nucleotide sequence ID" value="NM_001373243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18591"/>
    <dbReference type="SMR" id="Q18591"/>
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    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001618"/>
    <dbReference type="CTD" id="180547"/>
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        <property type="protein sequence ID" value="CE41776"/>
        <property type="gene ID" value="WBGene00001618"/>
        <property type="gene designation" value="glr-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007257_7_1_1"/>
    <dbReference type="OMA" id="TYTIYEV"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="PhylomeDB" id="Q18591"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001618">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18591">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13717">
        <property type="entry name" value="PBP2_iGluR_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLutamate Receptor family (AMPA)"/>
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    </dbReference>
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        <property type="entry name" value="Glutamate receptor ionotropic, kainate"/>
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    </dbReference>
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        <property type="entry name" value="Ionotropic receptor 25a"/>
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    </dbReference>
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        <property type="entry name" value="Glu/Gly-bd"/>
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        <property type="entry name" value="Iono_Glu_rcpt_met"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <end position="381"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="576"/>
            <end position="601"/>
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        <location>
            <begin position="159"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="19">
        <location>
            <begin position="169"/>
            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="630"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="14">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="14">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="503"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCD67188.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="C43H6.9a"/>
        </source>
    </evidence>
    <sequence length="671" mass="76798" checksum="108A7609D1F86519" modified="2008-01-15" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2026-01-28" version="167" xmlns="https://uniprot.org/uniprot">
    <accession>Q18801-2</accession>
    <name>GMD1_CAEEL</name>
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        <recommendedName>
            <fullName>Isoform a of GDP-mannose 4,6 dehydratase 1</fullName>
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            <fullName>Bacillus thuringiensis toxin-resistant protein 1</fullName>
            <shortName>Bt toxin-resistant protein 1</shortName>
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        <alternativeName>
            <fullName>GDP-D-mannose dehydratase</fullName>
            <shortName>GMD</shortName>
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    </protein>
    <gene>
        <name type="primary">bre-1</name>
        <name type="synonym">gmd-1</name>
        <name type="ORF">C53B4.7</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Genetics" volume="155" first="1693" last="1699">
            <title>Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Marroquin L.D."/>
                <person name="Elyassnia D."/>
                <person name="Griffitts J.S."/>
                <person name="Feitelson J.S."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="10924467"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="FEBS J." volume="273" first="2244" last="2256">
            <title>Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.</title>
            <authorList>
                <person name="Rhomberg S."/>
                <person name="Fuchsluger C."/>
                <person name="Rendic D."/>
                <person name="Paschinger K."/>
                <person name="Jantsch V."/>
                <person name="Kosma P."/>
                <person name="Wilson I.B.H."/>
            </authorList>
            <dbReference type="PubMed" id="16650000"/>
            <dbReference type="DOI" id="10.1111/j.1742-4658.2006.05239.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="J. Biol. Chem." volume="282" first="3302" last="3311">
            <title>Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose.</title>
            <authorList>
                <person name="Barrows B.D."/>
                <person name="Haslam S.M."/>
                <person name="Bischof L.J."/>
                <person name="Morris H.R."/>
                <person name="Dell A."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="17135259"/>
            <dbReference type="DOI" id="10.1074/jbc.M606621200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-232</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="J. Invertebr. Pathol." volume="95" first="198" last="200">
            <title>Resistance is non-futile: resistance to Cry5B in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Barrows B.D."/>
                <person name="Griffitts J.S."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="17482642"/>
            <dbReference type="DOI" id="10.1016/j.jip.2007.04.002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="PLoS Pathog." volume="6" first="E1000717" last="E1000717">
            <title>Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.</title>
            <authorList>
                <person name="Butschi A."/>
                <person name="Titz A."/>
                <person name="Waelti M.A."/>
                <person name="Olieric V."/>
                <person name="Paschinger K."/>
                <person name="Noebauer K."/>
                <person name="Guo X."/>
                <person name="Seeberger P.H."/>
                <person name="Wilson I.B."/>
                <person name="Aebi M."/>
                <person name="Hengartner M.O."/>
                <person name="Kuenzler M."/>
            </authorList>
            <dbReference type="PubMed" id="20062796"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000717"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-232</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q18801-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_032086"/>
        </isoform>
        <isoform>
            <id>Q18801-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_032085"/>
        </isoform>
        <isoform>
            <id>Q18801-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q18801-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_032084"/>
        </isoform>
        <isoform>
            <id>Q18801-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_013810"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="4.2.1.47"/>
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        <property type="protein sequence ID" value="CE27116"/>
        <property type="gene ID" value="WBGene00000266"/>
        <property type="gene designation" value="bre-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <accession>Q18801-3</accession>
    <name>GMD1_CAEEL</name>
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            <fullName>Isoform c of GDP-mannose 4,6 dehydratase 1</fullName>
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            <fullName>Bacillus thuringiensis toxin-resistant protein 1</fullName>
            <shortName>Bt toxin-resistant protein 1</shortName>
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        <alternativeName>
            <fullName>GDP-D-mannose dehydratase</fullName>
            <shortName>GMD</shortName>
        </alternativeName>
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    <gene>
        <name type="primary">bre-1</name>
        <name type="synonym">gmd-1</name>
        <name type="ORF">C53B4.7</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Genetics" volume="155" first="1693" last="1699">
            <title>Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Marroquin L.D."/>
                <person name="Elyassnia D."/>
                <person name="Griffitts J.S."/>
                <person name="Feitelson J.S."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="10924467"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="FEBS J." volume="273" first="2244" last="2256">
            <title>Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.</title>
            <authorList>
                <person name="Rhomberg S."/>
                <person name="Fuchsluger C."/>
                <person name="Rendic D."/>
                <person name="Paschinger K."/>
                <person name="Jantsch V."/>
                <person name="Kosma P."/>
                <person name="Wilson I.B.H."/>
            </authorList>
            <dbReference type="PubMed" id="16650000"/>
            <dbReference type="DOI" id="10.1111/j.1742-4658.2006.05239.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="J. Biol. Chem." volume="282" first="3302" last="3311">
            <title>Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose.</title>
            <authorList>
                <person name="Barrows B.D."/>
                <person name="Haslam S.M."/>
                <person name="Bischof L.J."/>
                <person name="Morris H.R."/>
                <person name="Dell A."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="17135259"/>
            <dbReference type="DOI" id="10.1074/jbc.M606621200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-232</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="J. Invertebr. Pathol." volume="95" first="198" last="200">
            <title>Resistance is non-futile: resistance to Cry5B in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Barrows B.D."/>
                <person name="Griffitts J.S."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="17482642"/>
            <dbReference type="DOI" id="10.1016/j.jip.2007.04.002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="PLoS Pathog." volume="6" first="E1000717" last="E1000717">
            <title>Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.</title>
            <authorList>
                <person name="Butschi A."/>
                <person name="Titz A."/>
                <person name="Waelti M.A."/>
                <person name="Olieric V."/>
                <person name="Paschinger K."/>
                <person name="Noebauer K."/>
                <person name="Guo X."/>
                <person name="Seeberger P.H."/>
                <person name="Wilson I.B."/>
                <person name="Aebi M."/>
                <person name="Hengartner M.O."/>
                <person name="Kuenzler M."/>
            </authorList>
            <dbReference type="PubMed" id="20062796"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000717"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-232</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q18801-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_013810"/>
        </isoform>
        <isoform>
            <id>Q18801-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_032085"/>
        </isoform>
        <isoform>
            <id>Q18801-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_032084"/>
        </isoform>
        <isoform>
            <id>Q18801-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_032086"/>
        </isoform>
        <isoform>
            <id>Q18801-1</id>
            <name>b</name>
            <sequence type="displayed"/>
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    <dbReference type="EC" id="4.2.1.47"/>
    <dbReference type="RefSeq" id="NP_001076668.1">
        <property type="nucleotide sequence ID" value="NM_001083199.4"/>
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    <dbReference type="WormBase" id="C53B4.7c">
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        <property type="gene designation" value="bre-1"/>
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        <property type="component" value="Chromosome IV"/>
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    <accession>Q18801-4</accession>
    <name>GMD1_CAEEL</name>
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            <fullName>Isoform d of GDP-mannose 4,6 dehydratase 1</fullName>
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        <alternativeName>
            <fullName>GDP-D-mannose dehydratase</fullName>
            <shortName>GMD</shortName>
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    <gene>
        <name type="primary">bre-1</name>
        <name type="synonym">gmd-1</name>
        <name type="ORF">C53B4.7</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Genetics" volume="155" first="1693" last="1699">
            <title>Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Marroquin L.D."/>
                <person name="Elyassnia D."/>
                <person name="Griffitts J.S."/>
                <person name="Feitelson J.S."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="10924467"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="FEBS J." volume="273" first="2244" last="2256">
            <title>Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.</title>
            <authorList>
                <person name="Rhomberg S."/>
                <person name="Fuchsluger C."/>
                <person name="Rendic D."/>
                <person name="Paschinger K."/>
                <person name="Jantsch V."/>
                <person name="Kosma P."/>
                <person name="Wilson I.B.H."/>
            </authorList>
            <dbReference type="PubMed" id="16650000"/>
            <dbReference type="DOI" id="10.1111/j.1742-4658.2006.05239.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="J. Biol. Chem." volume="282" first="3302" last="3311">
            <title>Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose.</title>
            <authorList>
                <person name="Barrows B.D."/>
                <person name="Haslam S.M."/>
                <person name="Bischof L.J."/>
                <person name="Morris H.R."/>
                <person name="Dell A."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="17135259"/>
            <dbReference type="DOI" id="10.1074/jbc.M606621200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-232</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="J. Invertebr. Pathol." volume="95" first="198" last="200">
            <title>Resistance is non-futile: resistance to Cry5B in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Barrows B.D."/>
                <person name="Griffitts J.S."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="17482642"/>
            <dbReference type="DOI" id="10.1016/j.jip.2007.04.002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="PLoS Pathog." volume="6" first="E1000717" last="E1000717">
            <title>Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.</title>
            <authorList>
                <person name="Butschi A."/>
                <person name="Titz A."/>
                <person name="Waelti M.A."/>
                <person name="Olieric V."/>
                <person name="Paschinger K."/>
                <person name="Noebauer K."/>
                <person name="Guo X."/>
                <person name="Seeberger P.H."/>
                <person name="Wilson I.B."/>
                <person name="Aebi M."/>
                <person name="Hengartner M.O."/>
                <person name="Kuenzler M."/>
            </authorList>
            <dbReference type="PubMed" id="20062796"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000717"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-232</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q18801-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q18801-4</id>
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            <sequence type="described" ref="VSP_032086"/>
        </isoform>
        <isoform>
            <id>Q18801-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_032085"/>
        </isoform>
        <isoform>
            <id>Q18801-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_013810"/>
        </isoform>
        <isoform>
            <id>Q18801-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_032084"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="4.2.1.47"/>
    <dbReference type="RefSeq" id="NP_001076669.1">
        <property type="nucleotide sequence ID" value="NM_001083200.4"/>
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    <dbReference type="WormBase" id="C53B4.7d">
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        <property type="gene ID" value="WBGene00000266"/>
        <property type="gene designation" value="bre-1"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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<entry dataset="Swiss-Prot" created="2000-12-01" modified="2026-01-28" version="167" xmlns="https://uniprot.org/uniprot">
    <accession>Q18801-5</accession>
    <name>GMD1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform e of GDP-mannose 4,6 dehydratase 1</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName>Bacillus thuringiensis toxin-resistant protein 1</fullName>
            <shortName>Bt toxin-resistant protein 1</shortName>
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        <alternativeName>
            <fullName>GDP-D-mannose dehydratase</fullName>
            <shortName>GMD</shortName>
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    </protein>
    <gene>
        <name type="primary">bre-1</name>
        <name type="synonym">gmd-1</name>
        <name type="ORF">C53B4.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Genetics" volume="155" first="1693" last="1699">
            <title>Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Marroquin L.D."/>
                <person name="Elyassnia D."/>
                <person name="Griffitts J.S."/>
                <person name="Feitelson J.S."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="10924467"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="FEBS J." volume="273" first="2244" last="2256">
            <title>Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.</title>
            <authorList>
                <person name="Rhomberg S."/>
                <person name="Fuchsluger C."/>
                <person name="Rendic D."/>
                <person name="Paschinger K."/>
                <person name="Jantsch V."/>
                <person name="Kosma P."/>
                <person name="Wilson I.B.H."/>
            </authorList>
            <dbReference type="PubMed" id="16650000"/>
            <dbReference type="DOI" id="10.1111/j.1742-4658.2006.05239.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="J. Biol. Chem." volume="282" first="3302" last="3311">
            <title>Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose.</title>
            <authorList>
                <person name="Barrows B.D."/>
                <person name="Haslam S.M."/>
                <person name="Bischof L.J."/>
                <person name="Morris H.R."/>
                <person name="Dell A."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="17135259"/>
            <dbReference type="DOI" id="10.1074/jbc.M606621200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-232</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="J. Invertebr. Pathol." volume="95" first="198" last="200">
            <title>Resistance is non-futile: resistance to Cry5B in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Barrows B.D."/>
                <person name="Griffitts J.S."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="17482642"/>
            <dbReference type="DOI" id="10.1016/j.jip.2007.04.002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="PLoS Pathog." volume="6" first="E1000717" last="E1000717">
            <title>Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.</title>
            <authorList>
                <person name="Butschi A."/>
                <person name="Titz A."/>
                <person name="Waelti M.A."/>
                <person name="Olieric V."/>
                <person name="Paschinger K."/>
                <person name="Noebauer K."/>
                <person name="Guo X."/>
                <person name="Seeberger P.H."/>
                <person name="Wilson I.B."/>
                <person name="Aebi M."/>
                <person name="Hengartner M.O."/>
                <person name="Kuenzler M."/>
            </authorList>
            <dbReference type="PubMed" id="20062796"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000717"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-232</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q18801-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_013810"/>
        </isoform>
        <isoform>
            <id>Q18801-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q18801-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_032086"/>
        </isoform>
        <isoform>
            <id>Q18801-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_032084"/>
        </isoform>
        <isoform>
            <id>Q18801-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_032085"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="4.2.1.47"/>
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        <property type="nucleotide sequence ID" value="NM_001083201.4"/>
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        <property type="protein sequence ID" value="CE40448"/>
        <property type="gene ID" value="WBGene00000266"/>
        <property type="gene designation" value="bre-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <proteinExistence type="evidence at transcript level"/>
    <sequence length="394" mass="44063" checksum="DA5674C9420E58FD" modified="2005-05-24" version="3">MNSHDSKIFCQTCSNGNNQGLEACIGMSHEVSTTPAAELAAFRARKVALITGISGQDGSYLAELLLSKGYKVHGIIRRSSSFNTARIEHLYSNPITHHGDSSFSLHYGDMTDSSCLIKLISTIEPTEVYHLAAQSHVKVSFDLPEYTAEVDAVGTLRLLDAIHACRLTEKVRFYQASTSELYGKVQEIPQSEKTPFYPRSPYAVAKMYGYWIVVNYREAYNMFACNGILFNHESPRRGETFVTRKITRSVAKISLGQQESIELGNLSALRDWGHAREYVEAMWRILQHDSPDDFVIATGKQFSVREFCNLAFAEIGEVLQWEGEGVEEVGKNKDGVIRVKVSPKYYRPTEVETLLGNAEKAKKTLGWEAKVTVPELVKEMVASDIILMKSNPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="169" xmlns="https://uniprot.org/uniprot">
    <accession>Q19902</accession>
    <name>Q19902_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ztf-26</name>
        <name evidence="7" type="ORF">CELE_F55H12.6</name>
        <name evidence="9" type="ORF">F55H12.6</name>
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    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB00096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21545">
        <property type="entry name" value="T21545"/>
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    <dbReference type="RefSeq" id="NP_001021503.1">
        <property type="nucleotide sequence ID" value="NM_001026332.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19902"/>
    <dbReference type="DIP" id="DIP-26986N"/>
    <dbReference type="IntAct" id="Q19902">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="172699"/>
    <dbReference type="UCSC" id="F55H12.6c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010137"/>
    <dbReference type="CTD" id="172699"/>
    <dbReference type="WormBase" id="F55H12.6b">
        <property type="protein sequence ID" value="CE05764"/>
        <property type="gene ID" value="WBGene00010137"/>
        <property type="gene designation" value="ztf-26"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052720_0_0_1"/>
    <dbReference type="OMA" id="IRHLRCK"/>
    <dbReference type="OrthoDB" id="5798336at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010137">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q19902">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS00028">
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="252"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB00096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F55H12.6b"/>
        </source>
    </evidence>
    <sequence length="286" mass="32202" checksum="72226AFE5B539B6E" modified="1996-11-01" version="1">MSHINLYSLPTDHKNMIRCRYCEKIYKIDNGSSGFIRHLRCKHPNVLYQMGAISNGKEYNLITKQETLSIDTNNEINLRDDDDFMMMKEFSSNQILVNFLSQLDLPTNDVNRVLGKRHRISPTPTINSSVTPNEEHEPDLKMFNSGDTLQNFLIDIDNHIRQKNQESQEAIGTGEESTSASALDMPSSQKESREPSPNSSMLDETNGGTETGDSSPTPFNPARPFGCVICPCSFPRVKDLTIHVTSVHRTRFRCNTCLAEFVQPQHLEHHYSISHAGTSTGTVVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-05-16" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q1RS87</accession>
    <name>Q1RS87_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </submittedName>
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    <gene>
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        <name evidence="4" type="ORF">CELE_F28B3.4</name>
        <name evidence="6" type="ORF">F28B3.4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD69831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491483.4">
        <property type="nucleotide sequence ID" value="NM_059082.7"/>
    </dbReference>
    <dbReference type="SMR" id="Q1RS87"/>
    <dbReference type="PaxDb" id="6239-F28B3.1.2"/>
    <dbReference type="PeptideAtlas" id="Q1RS87"/>
    <dbReference type="GeneID" id="3565539"/>
    <dbReference type="UCSC" id="F28B3.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017885"/>
    <dbReference type="CTD" id="3565539"/>
    <dbReference type="WormBase" id="F28B3.4d">
        <property type="protein sequence ID" value="CE41896"/>
        <property type="gene ID" value="WBGene00017885"/>
        <property type="gene designation" value="dip-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="PhylomeDB" id="Q1RS87"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017885">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1RS87">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="711"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="1196"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD69831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F28B3.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q1RS87"/>
        </source>
    </evidence>
    <sequence length="1307" mass="141443" checksum="7080D47FA9A887E2" modified="2008-02-05" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="188" xmlns="https://uniprot.org/uniprot">
    <accession>Q20888</accession>
    <name>Q20888_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">klp-4</name>
        <name evidence="13" type="ORF">CELE_F56E3.3</name>
        <name evidence="15" type="ORF">F56E3.3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD64593.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379674.1">
        <property type="nucleotide sequence ID" value="NM_001392742.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q20888"/>
    <dbReference type="DIP" id="DIP-25512N"/>
    <dbReference type="PeptideAtlas" id="Q20888"/>
    <dbReference type="GeneID" id="180608"/>
    <dbReference type="UCSC" id="F56E3.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00002217"/>
    <dbReference type="CTD" id="180608"/>
    <dbReference type="WormBase" id="F56E3.3a">
        <property type="protein sequence ID" value="CE53151"/>
        <property type="gene ID" value="WBGene00002217"/>
        <property type="gene designation" value="klp-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002217">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q20888">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22706">
        <property type="entry name" value="FHA_KIF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000075">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000139">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="9"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1343"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1504"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="362"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1356"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1515"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD64593.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F56E3.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="Q20888"/>
        </source>
    </evidence>
    <sequence length="1561" mass="175283" checksum="D5702D4EC70CD103" modified="2019-07-31" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q21175-2</accession>
    <name>CPG8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Chondroitin proteoglycan 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cpg-8</name>
        <name type="ORF">K03B4.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="J. Cell Biol." volume="173" first="985" last="994">
            <title>Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2.</title>
            <authorList>
                <person name="Olson S.K."/>
                <person name="Bishop J.R."/>
                <person name="Yates J.R."/>
                <person name="Oegema K."/>
                <person name="Esko J.D."/>
            </authorList>
            <dbReference type="PubMed" id="16785326"/>
            <dbReference type="DOI" id="10.1083/jcb.200603003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>GLYCOSYLATION AT SER-61; SER-63; SER-84; SER-88 AND SER-109</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21175-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q21175-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_052686"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_872155.1">
        <property type="nucleotide sequence ID" value="NM_182355.5"/>
    </dbReference>
    <dbReference type="WormBase" id="K03B4.7b">
        <property type="protein sequence ID" value="CE33133"/>
        <property type="gene ID" value="WBGene00019357"/>
        <property type="gene designation" value="cpg-8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16785326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="K03B4.7a"/>
        </source>
    </evidence>
    <sequence length="99" mass="11281" checksum="AEEFCCCB4E8527A5" modified="2001-10-01" version="2" precursor="true">MRPFILLALLVSVTVAFNIFRDEVVPEEQLLAVRRTTRDASDSSSDSDEKDDAKTTVTVSFGLSGSQAWPIFQFFSFALKTKKKSKFFRRSGYELRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q2XN01</accession>
    <name>Q2XN01_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F17H10.2</name>
        <name evidence="2 4" type="ORF">F17H10.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAJ43435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041246.1">
        <property type="nucleotide sequence ID" value="NM_001047781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2XN01"/>
    <dbReference type="SMR" id="Q2XN01"/>
    <dbReference type="PeptideAtlas" id="Q2XN01"/>
    <dbReference type="GeneID" id="184623"/>
    <dbReference type="KEGG" id="cel:CELE_F17H10.2"/>
    <dbReference type="UCSC" id="F17H10.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008926"/>
    <dbReference type="CTD" id="184623"/>
    <dbReference type="WormBase" id="F17H10.2b">
        <property type="protein sequence ID" value="CE39242"/>
        <property type="gene ID" value="WBGene00008926"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1316461_0_0_1"/>
    <dbReference type="OrthoDB" id="5819326at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008926">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2XN01">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056709">
        <property type="entry name" value="DUF7807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851:SF5">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851">
        <property type="entry name" value="PROTEIN CBG05235-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25093">
        <property type="entry name" value="DUF7807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ43435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F17H10.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q2XN01"/>
        </source>
    </evidence>
    <sequence length="209" mass="23119" checksum="0293B884B4D2E51C" modified="2005-12-20" version="1">MDIAKTFDHEPFRHTDPKYKCLCNKMHVKQGCKCILAFLVIVVIIAALLLILNWNIGTWTTLIIHAILLLGVIACAGALFLAMKTEKENLLLPVAGIAVLGAIVSIVFLVFTIWSLIEPSGVTGQLVNNFVVSQNASMTDDQGLEENREDIQTVSAISVVLSLAGLAASLWVAFVVYKYYMYLKDMKFARVPKNQVHIEITDLKKGINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q2XN02</accession>
    <name>Q2XN02_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">copg-1</name>
        <name evidence="17" type="ORF">CELE_T14G10.5</name>
        <name evidence="19" type="ORF">T14G10.5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ43445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040989.1">
        <property type="nucleotide sequence ID" value="NM_001047524.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2XN02"/>
    <dbReference type="SMR" id="Q2XN02"/>
    <dbReference type="GeneID" id="177891"/>
    <dbReference type="UCSC" id="T14G10.5b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011775"/>
    <dbReference type="CTD" id="177891"/>
    <dbReference type="WormBase" id="T14G10.5b">
        <property type="protein sequence ID" value="CE39281"/>
        <property type="gene ID" value="WBGene00011775"/>
        <property type="gene designation" value="copg-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="PhylomeDB" id="Q2XN02"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011775">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2XN02">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000038">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000011">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="15">
        <location>
            <begin position="619"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="16">
        <location>
            <begin position="767"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAJ43445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="T14G10.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="Q2XN02"/>
        </source>
    </evidence>
    <sequence length="883" mass="97619" checksum="A5866944A64B027D" modified="2005-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q2XN03</accession>
    <name>Q2XN03_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_T05A1.5</name>
        <name evidence="7 9" type="ORF">T05A1.5</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ43449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040985.1">
        <property type="nucleotide sequence ID" value="NM_001047520.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2XN03"/>
    <dbReference type="SMR" id="Q2XN03"/>
    <dbReference type="GeneID" id="188077"/>
    <dbReference type="KEGG" id="cel:CELE_T05A1.5"/>
    <dbReference type="UCSC" id="T05A1.5b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011456"/>
    <dbReference type="CTD" id="188077"/>
    <dbReference type="WormBase" id="T05A1.5b">
        <property type="protein sequence ID" value="CE39276"/>
        <property type="gene ID" value="WBGene00011456"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839988_0_0_1"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011456">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2XN03">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="73"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ43449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="T05A1.5b"/>
        </source>
    </evidence>
    <sequence length="343" mass="38456" checksum="682EBB7821EF48D2" modified="2005-12-20" version="1">MNLDLPRCEKGSSGKLSDEELLARTIEKALKTKKLAQSPNMTSSIKVETSIKVEDLLDQIGIWHPYPLFITFSMAFLWLLSVMPTMSPSYMAPSSPCTLDNCSFVTVQNEFNITKTLIDPGEMTSSIFFLGNGILGQIYAVAADRIGRRPVLIASLFISGLSGIGAAYAPTFEIMLIGRFFQGSCFTALTMINWVMCCESISFSGHGYASVLFGLCWVIGYCSVSPLAMYFSTWRYVQLATSVPCVLFGILMMFTLPESFSFLVAKRKRDDLVKWIEMASRVGNEEIDYDADQIVDMSSREEDNESLLQTLKLVLQSKLMVTNTAVETFLWKFFDKIFTILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q2XN04</accession>
    <name>Q2XN04_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">col-181</name>
        <name evidence="7" type="ORF">CELE_W03G11.1</name>
        <name evidence="9" type="ORF">W03G11.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAJ43444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041296.1">
        <property type="nucleotide sequence ID" value="NM_001047831.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2XN04"/>
    <dbReference type="SMR" id="Q2XN04"/>
    <dbReference type="GeneID" id="181378"/>
    <dbReference type="UCSC" id="W03G11.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000754"/>
    <dbReference type="CTD" id="181378"/>
    <dbReference type="WormBase" id="W03G11.1b">
        <property type="protein sequence ID" value="CE03781"/>
        <property type="gene ID" value="WBGene00000754"/>
        <property type="gene designation" value="col-181"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001074_4_2_1"/>
    <dbReference type="OrthoDB" id="5868420at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000754">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2XN04">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF239">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ43444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="W03G11.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q2XN04"/>
        </source>
    </evidence>
    <sequence length="279" mass="27199" checksum="5273740A0549B93A" modified="2005-12-20" version="1">MDKKFETEKVKRFAFFGIAVSTVSTLTAIVAVPMLCLYLQSVSSSLQDEVNFCRVRATSLEGELAKLNVVRAPRKARAAEGTCCSCGVGSAGPPGPPGFDGSAGKDGSNGRPGNPGEDADGDDYKPDASQFCFDCPEAPAGPPGRPGPDGENGGAGEPGRDGLAGRPGARGSPGPRGPSGNPGADGPAGQLGPQGGSNVAPSPAGEPGAPGAQGPKGPPGAAGRPGRDGQPGAPGDQGENGPDGAPGKSGSDGQPGAPGKEGSRGGCDHCPPPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q2XN08</accession>
    <name>Q2XN08_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein aurora borealis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_ZK673.11</name>
        <name evidence="2 4" type="ORF">ZK673.11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAJ43439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2XN08"/>
    <dbReference type="UCSC" id="ZK673.11a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00014065"/>
    <dbReference type="WormBase" id="ZK673.11b">
        <property type="protein sequence ID" value="CE39309"/>
        <property type="gene ID" value="WBGene00014065"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5825563at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014065">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2XN08">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ43439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZK673.11b"/>
        </source>
    </evidence>
    <sequence length="338" mass="37211" checksum="E3384634124E8F76" modified="2005-12-20" version="1">MFCCTRAQRKKAAEKISGSLRKHDSGPMFARLEEFDVLTPLQTTPAVSIASGNYKNYGSSSPSTSSGSDSRIQLLPPILSSSSSDSPPPPRRPNHGKTLIVPLNASRYRSPMTMNLVGTPDSRLTSFECGTTKSCATIPEDDEDEMNELLSIDRTSLSVYEQPSGRYGYSAYNLCLPQPTPEFQLPAPTYSPPSLPSESPASKPTKIDIPEAILNDRDDILDREDDHNEDQVSIYEFSRVSDPNSEHSSSNSISDSFYLNNFDVISSAANSQIFEASICGESDVASKFQLHRIEEESENGDEQSCAGAHDPLINSMTHSPSQFFPRSISQQFDMMRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q2Z1N7</accession>
    <name>Q2Z1N7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_Y25C1A.7</name>
        <name evidence="8 10" type="ORF">Y25C1A.7</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2Z1N7"/>
    <dbReference type="UCSC" id="Y25C1A.7c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021294"/>
    <dbReference type="WormBase" id="Y25C1A.7a">
        <property type="protein sequence ID" value="CE38563"/>
        <property type="gene ID" value="WBGene00021294"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059606_0_1_1"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021294">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2Z1N7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="100"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD61983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y25C1A.7a"/>
        </source>
    </evidence>
    <sequence length="277" mass="30777" checksum="291C02F6E707E8B1" modified="2005-12-20" version="1">MDLNFQNFDNVNSTNEQSGAFGGNIGDRNILVGGSVGATSSAAPSGGVFDDSQSTTSTRKGNFFSFEYYQQFFDVETDQVIKRLLNSVIPTHRNYIQDFLQPIPDLWGPFWVSVTLVFAIGIFGNLAQFIENDGAKGTYGSDFRMVTSASTLIFLYVVIVPLLLYGLLWNRRSELLHPYVDLVCLYGYSLAIFIPVSVLWIVDIGWFRWALIFASVGLSGTVLARAIWPAVQNDNNKMIAFGTVISVVVLHFLLAFTFKVYFFDSMHIVVVASPSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q2Z1N9</accession>
    <name>Q2Z1N9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prion-like-(Q/N-rich)-domain-bearing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">pqn-72</name>
        <name evidence="3" type="ORF">CELE_W01B11.5</name>
        <name evidence="5" type="ORF">W01B11.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122527.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2Z1N9"/>
    <dbReference type="PaxDb" id="6239-W01B11.5b"/>
    <dbReference type="GeneID" id="189086"/>
    <dbReference type="KEGG" id="cel:CELE_W01B11.5"/>
    <dbReference type="AGR" id="WB:WBGene00004154"/>
    <dbReference type="CTD" id="189086"/>
    <dbReference type="WormBase" id="W01B11.5b">
        <property type="protein sequence ID" value="CE42027"/>
        <property type="gene ID" value="WBGene00004154"/>
        <property type="gene designation" value="pqn-72"/>
    </dbReference>
    <dbReference type="OMA" id="IRPGHRH"/>
    <dbReference type="OrthoDB" id="5872502at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2Z1N9">
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    <keyword evidence="3" id="KW-0034">Amyloid</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
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            <end position="559"/>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="378"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="117"/>
        </location>
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        <location>
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        <location>
            <begin position="303"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="W01B11.5b"/>
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    <sequence length="559" mass="61524" checksum="45760EEE88E6BC63" modified="2012-01-25" version="2"> </sequence>
</entry>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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            <begin position="267"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF07735"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCD72043.1"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T05H4.15c"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="2" key="1">
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            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="MBio" volume="11" first="0" last="0">
            <title>Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is Modulated by mir-243.</title>
            <authorList>
                <person name="Gabaldon C."/>
                <person name="Leguee M."/>
                <person name="Palominos M.F."/>
                <person name="Verdugo L."/>
                <person name="Gutzwiller F."/>
                <person name="Calixto A."/>
            </authorList>
            <dbReference type="PubMed" id="32963007"/>
            <dbReference type="DOI" id="10.1128/mbio.01950-20"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION BY PATHOGEN</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q4JFH9-1</id>
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            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q4JFH9-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_061113"/>
        </isoform>
        <isoform>
            <id>Q4JFH9-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061111"/>
        </isoform>
        <isoform>
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            <sequence type="described" ref="VSP_061112"/>
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    </comment>
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    </dbReference>
    <dbReference type="WormBase" id="C27D6.4a">
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        <property type="gene ID" value="WBGene00016162"/>
        <property type="gene designation" value="crh-2"/>
    </dbReference>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
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    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C27D6.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C27D6.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C27D6.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C27D6.4d"/>
        </source>
    </evidence>
    <sequence length="224" mass="25519" checksum="30E9CD120410C6F3" modified="2013-10-16" version="3">MATRCTANVFIKDEIKEEQLEDHGIEMDLSALLNSRAGTNSHDSSPDEEEHDMTIHSEMFLAAASADGLDGSEGSQEVMDVDDLLLRGMGLAAAQQQLKARNKMHEMAIRQHLITDQNITANGDLVLSAEERRTLVQEGYSIPQKYPLTKSEEESLKIVRRKIKNKLSAQESRRKRKEYIDALEGRLHCFSEENKSLKKQVHQLEASNRDLQQKLHQYESKEKM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q4JFH9-3</accession>
    <name>CRH2_CAEEL</name>
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        <recommendedName>
            <fullName evidence="1">Isoform b of CREB homolog crh-2</fullName>
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        <name evidence="5" type="primary">crh-2</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="MBio" volume="11" first="0" last="0">
            <title>Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is Modulated by mir-243.</title>
            <authorList>
                <person name="Gabaldon C."/>
                <person name="Leguee M."/>
                <person name="Palominos M.F."/>
                <person name="Verdugo L."/>
                <person name="Gutzwiller F."/>
                <person name="Calixto A."/>
            </authorList>
            <dbReference type="PubMed" id="32963007"/>
            <dbReference type="DOI" id="10.1128/mbio.01950-20"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION BY PATHOGEN</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q4JFH9-1</id>
            <name evidence="5">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q4JFH9-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_061113"/>
        </isoform>
        <isoform>
            <id>Q4JFH9-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_061112"/>
        </isoform>
        <isoform>
            <id>Q4JFH9-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061111"/>
        </isoform>
    </comment>
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    </dbReference>
    <dbReference type="WormBase" id="C27D6.4b">
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        <property type="gene ID" value="WBGene00016162"/>
        <property type="gene designation" value="crh-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C27D6.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C27D6.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C27D6.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C27D6.4d"/>
        </source>
    </evidence>
    <sequence length="329" mass="37140" checksum="94576795F5D17132" modified="2013-10-16" version="3">MDDDWATSGVLEKDVFISSVHDEKDTLDILKLFDNDIDGFSDDNFRIKMEPNDETSDYHGSSSGSPSSSLSSPNEFKDEPLGLDVHFGNSLFNAPFSPSATSSHSPSSYGMMHGSHSMASHQLHQQQLSPLPSVAHFSHSHHLQHHVVQHPSQASLQMNMNQIFSGPSHQYASSSVPHTFLFKDSTIYEGMGGMGLAAAQQQLKARNKMHEMAIRQHLITDQNITANGDLVLSAEERRTLVQEGYSIPQKYPLTKSEEESLKIVRRKIKNKLSAQESRRKRKEYIDALEGRLHCFSEENKSLKKQVHQLEASNRDLQQKLHQYESKEKM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q4JFH9-4</accession>
    <name>CRH2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of CREB homolog crh-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">crh-2</name>
        <name evidence="5" type="ORF">C27D6.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2020" name="MBio" volume="11" first="0" last="0">
            <title>Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is Modulated by mir-243.</title>
            <authorList>
                <person name="Gabaldon C."/>
                <person name="Leguee M."/>
                <person name="Palominos M.F."/>
                <person name="Verdugo L."/>
                <person name="Gutzwiller F."/>
                <person name="Calixto A."/>
            </authorList>
            <dbReference type="PubMed" id="32963007"/>
            <dbReference type="DOI" id="10.1128/mbio.01950-20"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION BY PATHOGEN</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q4JFH9-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_061112"/>
        </isoform>
        <isoform>
            <id>Q4JFH9-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_061113"/>
        </isoform>
        <isoform>
            <id>Q4JFH9-1</id>
            <name evidence="5">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q4JFH9-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061111"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001293486.1">
        <property type="nucleotide sequence ID" value="NM_001306557.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C27D6.4d">
        <property type="protein sequence ID" value="CE48416"/>
        <property type="gene ID" value="WBGene00016162"/>
        <property type="gene designation" value="crh-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C27D6.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C27D6.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C27D6.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C27D6.4d"/>
        </source>
    </evidence>
    <sequence length="219" mass="25175" checksum="6546A777A37F0123" modified="2013-10-16" version="3">MMHGSHSMASHQLHQQQLSPLPSVAHFSHSHHLQHHVVQHPSQASLQMNMNQIFSGPSHQYASSSVPHTFLFKDSTIYEGMGGMGLAAAQQQLKARNKMHEMAIRQHLITDQNITANGDLVLSAEERRTLVQEGYSIPQKYPLTKSEEESLKIVRRKIKNKLSAQESRRKRKEYIDALEGRLHCFSEENKSLKKQVHQLEASNRDLQQKLHQYESKEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2025-10-08" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>Q6ABG8</accession>
    <name>Q6ABG8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase CBL</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">sli-1</name>
        <name evidence="10" type="ORF">CELE_M02A10.3</name>
        <name evidence="12" type="ORF">M02A10.3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD62723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024798.1">
        <property type="nucleotide sequence ID" value="NM_001029627.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6ABG8"/>
    <dbReference type="SMR" id="Q6ABG8"/>
    <dbReference type="GeneID" id="180419"/>
    <dbReference type="UCSC" id="M02A10.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004829"/>
    <dbReference type="CTD" id="180419"/>
    <dbReference type="WormBase" id="M02A10.3c">
        <property type="protein sequence ID" value="CE37131"/>
        <property type="gene ID" value="WBGene00004829"/>
        <property type="gene designation" value="sli-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013535_2_0_1"/>
    <dbReference type="OrthoDB" id="7237699at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004829">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6ABG8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040027">
        <property type="term" value="P:negative regulation of vulval development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09920">
        <property type="entry name" value="SH2_Cbl-b_TKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000367">
        <property type="entry name" value="Cbl proto-oncogene C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.20:FF:000007">
        <property type="entry name" value="Cbl proto-oncogene C, E3 ubiquitin protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000594">
        <property type="entry name" value="Suppressor of LIneage defect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024162">
        <property type="entry name" value="Adaptor_Cbl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014741">
        <property type="entry name" value="Adaptor_Cbl_EF_hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003153">
        <property type="entry name" value="Adaptor_Cbl_N_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014742">
        <property type="entry name" value="Adaptor_Cbl_SH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024159">
        <property type="entry name" value="Cbl_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007">
        <property type="entry name" value="CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007:SF11">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02262">
        <property type="entry name" value="Cbl_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02761">
        <property type="entry name" value="Cbl_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02762">
        <property type="entry name" value="Cbl_N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47668">
        <property type="entry name" value="N-terminal domain of cbl (N-cbl)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51506">
        <property type="entry name" value="CBL_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cbl-PTB" evidence="9">
        <location>
            <begin position="41"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD62723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="M02A10.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="Q6ABG8"/>
        </source>
    </evidence>
    <sequence length="523" mass="59805" checksum="FA09AD8FEBBB7493" modified="2004-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>Q86G92</accession>
    <name>Q86G92_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CELE_T04A8.7</name>
        <name evidence="9 11" type="ORF">T04A8.7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAD82917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_871631.1">
        <property type="nucleotide sequence ID" value="NM_181902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86G92"/>
    <dbReference type="SMR" id="Q86G92"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q86G92"/>
    <dbReference type="GeneID" id="3565201"/>
    <dbReference type="UCSC" id="T04A8.7a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011409"/>
    <dbReference type="CTD" id="3565201"/>
    <dbReference type="WormBase" id="T04A8.7b">
        <property type="protein sequence ID" value="CE33539"/>
        <property type="gene ID" value="WBGene00011409"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011131_2_2_1"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011409">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86G92">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="1,4-alpha-glucan-branching enzyme"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
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    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="8">
        <location>
            <begin position="120"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD82917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="T04A8.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="Q86G92"/>
        </source>
    </evidence>
    <sequence length="606" mass="69919" checksum="C8AED793D66D9C47" modified="2003-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q86G94</accession>
    <name>Q86G94_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">asd-1</name>
        <name evidence="6" type="ORF">CELE_R74.5</name>
        <name evidence="8" type="ORF">R74.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAD82915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379389.1">
        <property type="nucleotide sequence ID" value="NM_001393315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86G94"/>
    <dbReference type="SMR" id="Q86G94"/>
    <dbReference type="PeptideAtlas" id="Q86G94"/>
    <dbReference type="GeneID" id="175542"/>
    <dbReference type="UCSC" id="R74.5b.5">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011279"/>
    <dbReference type="CTD" id="175542"/>
    <dbReference type="WormBase" id="R74.5b">
        <property type="protein sequence ID" value="CE33537"/>
        <property type="gene ID" value="WBGene00011279"/>
        <property type="gene designation" value="asd-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046753_0_0_1"/>
    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011279">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86G94">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047131">
        <property type="entry name" value="RBFOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597">
        <property type="entry name" value="ATAXIN 2-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597:SF49">
        <property type="entry name" value="RNA-BINDING PROTEIN ASD-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD82915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="R74.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q86G94"/>
        </source>
    </evidence>
    <sequence length="286" mass="31119" checksum="FA4776997B092EA0" modified="2003-06-01" version="1">MFEKVGPVVDVEIIFNERGSKGFGFVTMQNPDDADRARAEFNGTTIEGRRVEVNLATQRVHNKKAKPLMSVGVDAMSAQNALISQQQQIQRAALLQQQLLAQQFLVPRHQQLMMPPTSAAAISQLQALQYQQALLAAQQQQQQMQNPQFLLSLQQQQQAQAQAPPTSMAQLIQHQQQFAMDPMAQAQAQAAQAQMVTLIAFEQQRMQLQAAAAAAQGRGVPQPGRIPTSTATTGSSQNQVAAGSIGEQYLQQSMQGAVPANFHHHSQALHPAAAAAAALQRRFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2025-10-08" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q86GT6</accession>
    <name>Q86GT6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">ser-7</name>
        <name evidence="15" type="ORF">C09B7.1</name>
        <name evidence="13" type="ORF">CELE_C09B7.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD83458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024373.1">
        <property type="nucleotide sequence ID" value="NM_001029202.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86GT6"/>
    <dbReference type="SMR" id="Q86GT6"/>
    <dbReference type="GeneID" id="180565"/>
    <dbReference type="KEGG" id="cel:CELE_C09B7.1"/>
    <dbReference type="UCSC" id="C09B7.1c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004780"/>
    <dbReference type="CTD" id="180565"/>
    <dbReference type="WormBase" id="C09B7.1c">
        <property type="protein sequence ID" value="CE17391"/>
        <property type="gene ID" value="WBGene00004780"/>
        <property type="gene designation" value="ser-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_11_1_1"/>
    <dbReference type="OrthoDB" id="5951059at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004780">
        <property type="expression patterns" value="Expressed in anatomical system and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86GT6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="69"/>
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            <authorList>
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                <person name="Moorman C."/>
                <person name="Lacefield C.O."/>
                <person name="Lehrer J."/>
                <person name="Bartsch D."/>
                <person name="Plasterk R.H."/>
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                <person name="Llamosas E."/>
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                <person name="Liao B.M."/>
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                <person name="Morton E.A."/>
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                <person name="Kim J.H."/>
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                <person name="Gao A.W."/>
                <person name="Sadler M.C."/>
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                <person name="Moorman C."/>
                <person name="Lacefield C.O."/>
                <person name="Lehrer J."/>
                <person name="Bartsch D."/>
                <person name="Plasterk R.H."/>
                <person name="Kandel E.R."/>
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                <person name="Llamosas E."/>
                <person name="Thaivalappil P."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19582" last="19582">
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                <person name="Wood M."/>
                <person name="Llamosas E."/>
                <person name="Thaivalappil P."/>
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                <person name="Liao B.M."/>
                <person name="Chew Y.L."/>
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                <person name="Morton E.A."/>
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                <person name="Kim J.H."/>
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                <person name="Milburn L."/>
                <person name="Ratnappan R."/>
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                <person name="Roy S."/>
                <person name="Gao A.W."/>
                <person name="Sadler M.C."/>
                <person name="von Alvensleben G.V.G."/>
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                <person name="Lazaro-Pena M.I."/>
                <person name="Cornwell A.B."/>
                <person name="Diaz-Balzac C.A."/>
                <person name="Das R."/>
                <person name="Ward Z.C."/>
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        <isoform>
            <id>Q8MQ70-1</id>
            <name evidence="6">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q8MQ70-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_057641"/>
        </isoform>
        <isoform>
            <id>Q8MQ70-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_057642"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_741763.1">
        <property type="nucleotide sequence ID" value="NM_171664.7"/>
    </dbReference>
    <dbReference type="WormBase" id="F20B6.8c">
        <property type="protein sequence ID" value="CE30962"/>
        <property type="gene ID" value="WBGene00001994"/>
        <property type="gene designation" value="hpk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q86Z02"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="23904186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F20B6.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F20B6.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F20B6.8c"/>
        </source>
    </evidence>
    <sequence length="740" mass="81987" checksum="5A21935994F2BF84" modified="2002-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N5R3</accession>
    <name>Q9N5R3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F56A4.3</name>
        <name evidence="2 4" type="ORF">F56A4.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD62313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_503673.2">
        <property type="nucleotide sequence ID" value="NM_071272.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N5R3"/>
    <dbReference type="SMR" id="Q9N5R3"/>
    <dbReference type="STRING" id="6239.F56A4.3.1"/>
    <dbReference type="PaxDb" id="6239-F56A4.3"/>
    <dbReference type="PeptideAtlas" id="Q9N5R3"/>
    <dbReference type="GeneID" id="186346"/>
    <dbReference type="UCSC" id="F56A4.3">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018911"/>
    <dbReference type="CTD" id="186346"/>
    <dbReference type="WormBase" id="F56A4.3a">
        <property type="protein sequence ID" value="CE30150"/>
        <property type="gene ID" value="WBGene00018911"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2239026_0_0_1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="PhylomeDB" id="Q9N5R3"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018911">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N5R3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000168">
        <property type="entry name" value="Glutathione S-transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF120">
        <property type="entry name" value="GST N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD62313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F56A4.3a"/>
        </source>
    </evidence>
    <sequence length="105" mass="12260" checksum="5700B009694A52C9" modified="2002-03-01" version="2">MAVPQLYYFTIRGFGEYIRLLFLDNGIKFEDIRFDYEGNEWQEFKKGMLLGQLPCLKVDGQEIVQTGAIMRHLGRVHGYWSLWSGNKNGRMPDRSSAVLQNLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N5S9</accession>
    <name>Q9N5S9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">acl-4</name>
        <name evidence="17" type="ORF">CELE_F49H12.6</name>
        <name evidence="19" type="ORF">F49H12.6</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD71582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508380.2">
        <property type="nucleotide sequence ID" value="NM_075979.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N5S9"/>
    <dbReference type="GeneID" id="180519"/>
    <dbReference type="UCSC" id="F49H12.6b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018657"/>
    <dbReference type="CTD" id="180519"/>
    <dbReference type="WormBase" id="F49H12.6b">
        <property type="protein sequence ID" value="CE30138"/>
        <property type="gene ID" value="WBGene00018657"/>
        <property type="gene designation" value="acl-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031080_2_0_1"/>
    <dbReference type="OrthoDB" id="10051137at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018657">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N5S9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="16">
        <location>
            <begin position="121"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="339"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCD71582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="F49H12.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N5S9"/>
        </source>
    </evidence>
    <sequence length="410" mass="46572" checksum="176486BE77DC0A9A" modified="2002-03-01" version="2">MEAIIEDEVTSRFEAEQLVSWNMLTRTSIKFYQFVNWKLSALWILGFMFRYCVMLPLRFTVFCIGLVFLISSTALIGLVPIGNWKKALNHKCMLICYRILSRSLTAVVYFHDEHYKAQAQGICVANHTSPIDALILSIDNVYALIGQKHEGLLGIVQRALSRASSHIWFERSEAKDRLVVAQKLKEHCTNPDKLPILIFPEGTCINNTSVMMFKKGSFEIGTTIYPIAMKYDSRFGDAFWNSSEQSWCGYIMRMMTSWAIICNVWYLPPMTRRDGEDAVDFANRVKKEIANKGGLVDLEWDGGLKRAKVPPKMVAKQQERYANRLSRYTSVSEVVKDEDVDVTSDSSSDLVDKPVSGYNSLEDLPEDVFIDEEEDETIDAHDENENDDPAGESNILPNKPLSDTVSLVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TYJ4</accession>
    <name>Q9TYJ4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosolic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y49F6C.7</name>
        <name evidence="2 4" type="ORF">Y49F6C.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD69502.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T33932">
        <property type="entry name" value="T33932"/>
    </dbReference>
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    <dbReference type="UCSC" id="Y49F6C.7">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00021729"/>
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        <property type="protein sequence ID" value="CE53822"/>
        <property type="gene ID" value="WBGene00021729"/>
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    <dbReference type="HOGENOM" id="CLU_1596016_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
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        <property type="expression patterns" value="Expressed in embryo and 1 other cell type or tissue"/>
    </dbReference>
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            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
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        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD69502.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y49F6C.7a"/>
        </source>
    </evidence>
    <sequence length="66" mass="7721" checksum="EC5F0C5B411224D1" modified="2020-04-22" version="3">MPPREEHQNLEENYQPARTPSFSATSWSPRFRCSWISTAKRSERGNESRQDCCETCGRWIIGSESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TYM8</accession>
    <name>Q9TYM8_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">CELE_Y37E11B.10</name>
        <name evidence="2 4" type="ORF">Y37E11B.10</name>
    </gene>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCD61347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T33898"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001307202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9TYM8"/>
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    <dbReference type="KEGG" id="cel:CELE_Y37E11B.10"/>
    <dbReference type="UCSC" id="Y37E11B.10a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021381"/>
    <dbReference type="CTD" id="24105065"/>
    <dbReference type="WormBase" id="Y37E11B.10a">
        <property type="protein sequence ID" value="CE28114"/>
        <property type="gene ID" value="WBGene00021381"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533448_0_0_1"/>
    <dbReference type="OrthoDB" id="5843289at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021381">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9TYM8">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="349"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
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            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD61347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y37E11B.10a"/>
        </source>
    </evidence>
    <sequence length="511" mass="53075" checksum="6CACEA0DD4009673" modified="2002-06-01" version="2">MSKSSKSQSQSKASSSDGAVCPPTACSTSLLTAEQLTDPPQIPTALSNSVNTAIGGTPSDFESNSGLSDTSAGSGRANSAVSETTTAMSATSPEIIMNDLRKGSLFGRQKGSLATTDGGPQSVTIITFSNNTNMSTASQPTSLDDKSQKSQKTGSMKTGIPMRSPGSSMAGKGAMSRKKSPKKQMDALKKEQVPAAPDFSKKSKKSKKSKKSKKARVARKPRMPKSSVDSTSSSDESGKSAKSAKSTKMAKKLVCPAPPMNADFSKKSTKSGKSAKIAKKVAAPVAPAVDGDFSKKSKKSVAKKSEAPPAFGQSGVVKKGDKQKQNDSVYFPGVNNPSTAKFGKSASCKPGQASTYNFPGAGKCARRMDEVAPPTPKLNAGDASHCVYNVAQLPPAQRRMPPPIATGAPKSLFGTRKAKTAPNPVPAPHVMSNTVAPTAPNASTRNKIVVFGTTPDGKSTIQMTIDMKVVAGEMLKGSDQPVDLVPKKVVVAGQEITVDSKSKNEKNEMPL</sequence>
</entry>
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        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">CELE_Y37E11B.1</name>
        <name evidence="3 5" type="ORF">Y37E11B.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD61338.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T33891">
        <property type="entry name" value="T33891"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9TYN5"/>
    <dbReference type="SMR" id="Q9TYN5"/>
    <dbReference type="IntAct" id="Q9TYN5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="UCSC" id="Y37E11B.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021374"/>
    <dbReference type="WormBase" id="Y37E11B.1a">
        <property type="protein sequence ID" value="CE48926"/>
        <property type="gene ID" value="WBGene00021374"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_2_1_1"/>
    <dbReference type="OrthoDB" id="5785100at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021374">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9TYN5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD61338.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y37E11B.1a"/>
        </source>
    </evidence>
    <sequence length="66" mass="7755" checksum="B8537E21F94441B8" modified="2013-12-11" version="3">MCYASFDLSDPFKIHLRKHDNLKPFGCSYCFKQFSSRSVCRRHVQLMHENQKRAGDGDNDDDDDID</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XTT2</accession>
    <name>Q9XTT2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CARD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cccp-1</name>
        <name evidence="3" type="ORF">CELE_Y49E10.23</name>
        <name evidence="5" type="ORF">Y49E10.23</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAB11567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T27055">
        <property type="entry name" value="T27055"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_499628.1">
        <property type="nucleotide sequence ID" value="NM_067227.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XTT2"/>
    <dbReference type="SMR" id="Q9XTT2"/>
    <dbReference type="DIP" id="DIP-27339N"/>
    <dbReference type="GeneID" id="176674"/>
    <dbReference type="KEGG" id="cel:CELE_Y49E10.23"/>
    <dbReference type="UCSC" id="Y49E10.23b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013042"/>
    <dbReference type="CTD" id="176674"/>
    <dbReference type="WormBase" id="Y49E10.23a">
        <property type="protein sequence ID" value="CE22238"/>
        <property type="gene ID" value="WBGene00013042"/>
        <property type="gene designation" value="cccp-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378668_0_0_1"/>
    <dbReference type="OrthoDB" id="5583482at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013042">
        <property type="expression patterns" value="Expressed in material anatomical entity and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XTT2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038830">
        <property type="entry name" value="CCDC186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911">
        <property type="entry name" value="CTCL TUMOR ANTIGEN HD-CL-01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="2">
        <location>
            <begin position="674"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB11567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y49E10.23a"/>
        </source>
    </evidence>
    <sequence length="734" mass="84686" checksum="BC684D9EB00D3A74" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XV11</accession>
    <name>Q9XV11_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F48F5.6</name>
        <name evidence="1 3" type="ORF">F48F5.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB04410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T22381"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256920.1">
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    </dbReference>
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    <dbReference type="UCSC" id="F48F5.3">
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    <dbReference type="WormBase" id="F48F5.6d">
        <property type="protein sequence ID" value="CE18709"/>
        <property type="gene ID" value="WBGene00009848"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2851796_0_0_1"/>
    <dbReference type="OrthoDB" id="5855105at2759"/>
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    </dbReference>
    <dbReference type="Bgee" id="WBGene00009848">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XV11">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB04410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F48F5.6d"/>
        </source>
    </evidence>
    <sequence length="65" mass="7640" checksum="E91F6BB79779D704" modified="1999-11-01" version="1">MTEEETDKKFEALQQMLKLGQYADEFDFDKTEIEAEIKGEPENVSIIDTGKETNCFKQHKNRQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XV15</accession>
    <name>Q9XV15_CAEEL</name>
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        <submittedName>
            <fullName evidence="6">Transthyretin-like family protein</fullName>
        </submittedName>
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        <name evidence="6 8" type="primary">ttr-11</name>
        <name evidence="6" type="ORF">CELE_F46B3.3</name>
        <name evidence="8" type="ORF">F46B3.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="WormBase" id="F46B3.3a">
        <property type="protein sequence ID" value="CE43938"/>
        <property type="gene ID" value="WBGene00009758"/>
        <property type="gene designation" value="ttr-11"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2388215_0_0_1"/>
    <dbReference type="OrthoDB" id="5771181at2759"/>
    <dbReference type="PhylomeDB" id="Q9XV15"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009758">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XV15">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF31">
        <property type="entry name" value="TRANSTHYRETIN-RELATED FAMILY DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004337745" evidence="5">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB04404.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F46B3.3a"/>
        </source>
    </evidence>
    <sequence length="106" mass="12149" checksum="3FF9ADF3DC8C7B3B" modified="2009-09-01" version="3">MNATIFLVVLLINYAAASTGSVHIRGRLLCNGRPYAREKIQIWEKNFALADTMLIHAVTDNDGYFDLQGSITETMMSPLLYAYFVNYCKPSFNWLRVKCDLRPPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>S6DQ91</accession>
    <name>S6DQ91_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">eat-4</name>
        <name evidence="8" type="ORF">CELE_ZK512.6</name>
        <name evidence="10" type="ORF">ZK512.6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCW46023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293625.1">
        <property type="nucleotide sequence ID" value="NM_001306696.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6DQ91"/>
    <dbReference type="SMR" id="S6DQ91"/>
    <dbReference type="GeneID" id="176291"/>
    <dbReference type="AGR" id="WB:WBGene00001135"/>
    <dbReference type="CTD" id="176291"/>
    <dbReference type="WormBase" id="ZK512.6b">
        <property type="protein sequence ID" value="CE48482"/>
        <property type="gene ID" value="WBGene00001135"/>
        <property type="gene designation" value="eat-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_0_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001135">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6DQ91">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17382">
        <property type="entry name" value="MFS_SLC17A6_7_8_VGluT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001492">
        <property type="entry name" value="Protein CBG06794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000264">
        <property type="entry name" value="vesicular glutamate transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF456">
        <property type="entry name" value="VESICULAR GLUTAMATE TRANSPORTER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCW46023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="ZK512.6b"/>
        </source>
    </evidence>
    <sequence length="555" mass="60706" checksum="FA2652BFA4F597A5" modified="2013-10-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>S6F5A3</accession>
    <name>S6F5A3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">magu-4</name>
        <name evidence="4" type="ORF">CELE_F44D12.1</name>
        <name evidence="6" type="ORF">F44D12.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDG24152.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368189.1">
        <property type="nucleotide sequence ID" value="NM_001380427.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6F5A3"/>
    <dbReference type="SMR" id="S6F5A3"/>
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    </dbReference>
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        <property type="protein sequence ID" value="CE52466"/>
        <property type="gene ID" value="WBGene00009678"/>
        <property type="gene designation" value="magu-4"/>
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        <property type="component" value="Chromosome IV"/>
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        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="MAGUK_Signaling_Regulators"/>
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    </dbReference>
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        <property type="entry name" value="DISKS LARGE HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46360:SF1">
        <property type="entry name" value="DISKS LARGE HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="232"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="311"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="2">
        <location>
            <begin position="914"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDG24152.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F44D12.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="S6F5A3"/>
        </source>
    </evidence>
    <sequence length="1082" mass="121827" checksum="365233DF2A175911" modified="2018-03-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCJ3</accession>
    <name>U4PCJ3_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">LIn-26 Related</fullName>
        </submittedName>
    </protein>
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        <name evidence="2 4" type="primary">lir-1</name>
        <name evidence="2" type="ORF">CELE_F18A1.3</name>
        <name evidence="4" type="ORF">F18A1.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368340.1">
        <property type="nucleotide sequence ID" value="NM_001381503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCJ3"/>
    <dbReference type="SMR" id="U4PCJ3"/>
    <dbReference type="GeneID" id="174240"/>
    <dbReference type="AGR" id="WB:WBGene00003044"/>
    <dbReference type="CTD" id="174240"/>
    <dbReference type="WormBase" id="F18A1.3k">
        <property type="protein sequence ID" value="CE48601"/>
        <property type="gene ID" value="WBGene00003044"/>
        <property type="gene designation" value="lir-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5775637at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003044">
        <property type="expression patterns" value="Expressed in embryo and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCJ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F18A1.3k"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PCJ3"/>
        </source>
    </evidence>
    <sequence length="142" mass="16348" checksum="9481EB72C1173D67" modified="2013-12-11" version="1">MFACNGSPNGGDVLRRKTPSRKAEDSIKATCKVCGHDVMYSPQRTWNLMRHVWIMHQSSKPNQCSICGYSHIKPYVRKHIESQHKHDSNATIIDLKSPELEAEWSQLLDQCFGVTYRKWKHHKEDTQHTGGLLFDDDELRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCJ9</accession>
    <name>U4PCJ9_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class Z</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srz-20</name>
        <name evidence="2" type="ORF">CELE_F56D6.5</name>
        <name evidence="4" type="ORF">F56D6.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294636.1">
        <property type="nucleotide sequence ID" value="NM_001307707.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCJ9"/>
    <dbReference type="GeneID" id="186389"/>
    <dbReference type="AGR" id="WB:WBGene00018973"/>
    <dbReference type="CTD" id="186389"/>
    <dbReference type="WormBase" id="F56D6.5b">
        <property type="protein sequence ID" value="CE49006"/>
        <property type="gene ID" value="WBGene00018973"/>
        <property type="gene designation" value="srz-20"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056063_2_1_1"/>
    <dbReference type="OrthoDB" id="5875403at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018817">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31720">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS Z-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31720:SF3">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS Z-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10325">
        <property type="entry name" value="7TM_GPCR_Srz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F56D6.5b"/>
        </source>
    </evidence>
    <sequence length="222" mass="26071" checksum="7729EE2DBB8C9554" modified="2013-12-11" version="1">MIFVVLSGIFVLIGTSETFNMLLFLLAITRAVIYFWPSNEKKIKTILIHIHKRVHYLYFAFITKTVIFFFVAMYMEWTDTNIWYILPAFVSIQVLLHVLIFVSAILHIPIMISIRKLSYLASAQQNNPQRYILWQIISVLMFKLIALPYIIFGIFDIDYVLEIIPFDCFLLPIIVQISYLGCNRRNVETLLTSFHLKKFIQVLFDRQTAVNPLSTTDQSTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCN0</accession>
    <name>U4PCN0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein asunder</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell cycle regulator Mat89Bb</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Set apart in position or space protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">ints-13</name>
        <name evidence="14" type="ORF">CELE_R02D3.4</name>
        <name evidence="16" type="ORF">R02D3.4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13, IntS14 and IntS15. The core complex associates with protein phosphatase 2A subunits mts/PP2A and Pp2A-29B, to form the Integrator-PP2A (INTAC) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Integrator subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368353.1">
        <property type="nucleotide sequence ID" value="NM_001379999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PCN0"/>
    <dbReference type="SMR" id="U4PCN0"/>
    <dbReference type="PeptideAtlas" id="U4PCN0"/>
    <dbReference type="GeneID" id="176839"/>
    <dbReference type="KEGG" id="cel:CELE_R02D3.4"/>
    <dbReference type="AGR" id="WB:WBGene00019822"/>
    <dbReference type="CTD" id="176839"/>
    <dbReference type="WormBase" id="R02D3.4b">
        <property type="protein sequence ID" value="CE48559"/>
        <property type="gene ID" value="WBGene00019822"/>
        <property type="gene designation" value="ints-13"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018072_0_0_1"/>
    <dbReference type="OrthoDB" id="5844105at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019822">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PCN0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019355">
        <property type="entry name" value="Cell_cycle_regulator_Mat89Bb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-95-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10221">
        <property type="entry name" value="Mat89Bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="482"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDH93496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="R02D3.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="U4PCN0"/>
        </source>
    </evidence>
    <sequence length="520" mass="59617" checksum="6669B3F1E8BFE229" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLY1</accession>
    <name>V6CLY1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">unc-77</name>
        <name evidence="27" type="ORF">C11D2.6</name>
        <name evidence="25" type="ORF">CELE_C11D2.6</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293821.1">
        <property type="nucleotide sequence ID" value="NM_001306892.3"/>
    </dbReference>
    <dbReference type="SMR" id="V6CLY1"/>
    <dbReference type="GeneID" id="177379"/>
    <dbReference type="AGR" id="WB:WBGene00006809"/>
    <dbReference type="CTD" id="177379"/>
    <dbReference type="WormBase" id="C11D2.6j">
        <property type="protein sequence ID" value="CE49219"/>
        <property type="gene ID" value="WBGene00006809"/>
        <property type="gene designation" value="unc-77"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006809">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLY1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000089">
        <property type="entry name" value="Four domain-type voltage-gated ion channel alpha-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000080">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000060">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000061">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000066">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000030">
        <property type="entry name" value="sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000032">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000034">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF2">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="878"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="923"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="958"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1020"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1134"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1215"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1247"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1287"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1321"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1359"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1444"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="69"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="417"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="884"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="1213"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1647"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1656"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="1672"/>
            <end position="1682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDK13573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="C11D2.6j"/>
        </source>
    </evidence>
    <sequence length="1786" mass="206438" checksum="5598FE0BDBA12D28" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLY6</accession>
    <name>V6CLY6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">unc-77</name>
        <name evidence="27" type="ORF">C11D2.6</name>
        <name evidence="25" type="ORF">CELE_C11D2.6</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001306897.3"/>
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    </dbReference>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
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        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
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    <keyword evidence="6" id="KW-0677">Repeat</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="435"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="559"/>
            <end position="582"/>
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    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="628"/>
            <end position="652"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="896"/>
            <end position="921"/>
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        <location>
            <begin position="941"/>
            <end position="964"/>
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    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="976"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1038"/>
            <end position="1060"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="1152"/>
            <end position="1178"/>
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    <feature type="transmembrane region" description="Helical" evidence="23">
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00061650"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDK13578.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="C11D2.6o"/>
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    <sequence length="1833" mass="211603" checksum="ED0BADAF4C7B1BCF" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLY7</accession>
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        <alternativeName>
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        </alternativeName>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF2">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="912"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="957"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="992"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1054"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1168"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1281"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1321"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1355"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1393"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1478"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="69"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="417"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="918"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="1247"/>
            <end position="1515"/>
        </location>
    </feature>
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        <location>
            <begin position="813"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1681"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1690"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="1706"/>
            <end position="1716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDK13572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="C11D2.6i"/>
        </source>
    </evidence>
    <sequence length="1849" mass="213518" checksum="D197B551116DD0C4" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLY9</accession>
    <name>V6CLY9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y73B6A.1</name>
        <name evidence="2 4" type="ORF">Y73B6A.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLY9"/>
    <dbReference type="SMR" id="V6CLY9"/>
    <dbReference type="AGR" id="WB:WBGene00022228"/>
    <dbReference type="WormBase" id="Y73B6A.1b">
        <property type="protein sequence ID" value="CE49385"/>
        <property type="gene ID" value="WBGene00022228"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_664373_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022228">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLY9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y73B6A.1b"/>
        </source>
    </evidence>
    <sequence length="225" mass="24940" checksum="08C0E4B78B57496F" modified="2014-02-19" version="1">MKVLHVPGEISADTAKDEITVMKKVGSAVFRKKNPSFLEFLGAYLVEGHSKTDPKLQFKNKNGHPLPEKAQFVAIFMELVEGGRSIGDFPFKTDNERKSFVCQLVVGLMTAQKELGFSHGDLSVDNTIVTKTKLRTVAYILEGKAVKLKTSGVLLKIIDYGKSECSSDNKASTSFEDSDYTKLRNHAMDVFKVPGLKALADAVNNYDEEHASWYPNSELFNGLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLZ1</accession>
    <name>V6CLZ1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">unc-77</name>
        <name evidence="27" type="ORF">C11D2.6</name>
        <name evidence="25" type="ORF">CELE_C11D2.6</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293825.1">
        <property type="nucleotide sequence ID" value="NM_001306896.3"/>
    </dbReference>
    <dbReference type="SMR" id="V6CLZ1"/>
    <dbReference type="GeneID" id="177379"/>
    <dbReference type="AGR" id="WB:WBGene00006809"/>
    <dbReference type="CTD" id="177379"/>
    <dbReference type="WormBase" id="C11D2.6n">
        <property type="protein sequence ID" value="CE49262"/>
        <property type="gene ID" value="WBGene00006809"/>
        <property type="gene designation" value="unc-77"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006809">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLZ1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000089">
        <property type="entry name" value="Four domain-type voltage-gated ion channel alpha-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000080">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000060">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000061">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000066">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000030">
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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        <property type="entry name" value="NALCN"/>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
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        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
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    <proteinExistence type="inferred from homology"/>
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            <end position="255"/>
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            <begin position="345"/>
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    <feature type="transmembrane region" description="Helical" evidence="23">
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        <location>
            <begin position="1038"/>
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            <begin position="1152"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00061650"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDK13577.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="C11D2.6n"/>
        </source>
    </evidence>
    <sequence length="1804" mass="208359" checksum="E5FE7AC3E5157377" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLZ2</accession>
    <name>V6CLZ2_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">CELE_Y34D9A.3</name>
        <name evidence="1 3" type="ORF">Y34D9A.3</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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        <property type="gene ID" value="WBGene00021329"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CDK13584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y34D9A.3c"/>
        </source>
    </evidence>
    <sequence length="371" mass="43051" checksum="5117DC6CA0755E2C" modified="2014-02-19" version="1">MKLLGAEKPKIHSYFKENRTKTKLLMNSELELAVEYLRDFSDYELNWFLQQRADEDFQFLLETAKNLQAPVNSDGFWRNSLEKFDENSIIFIENQLKIMATRIDRKGLALRIQQISQKMMQKSGKIEEKTAIFIKFPQILLEIADFSILPPNSSNLLFSTLILGFSAFYDGNEAQFNDLFRQFLSKTIPNSTCTSPMEIIEEICEKIRIKSNFRHLPDISFLKPNPDTIITQISEIFDTKIAKNDERIVEICSILLEKLAPQLQAFGDRGKTPFCQIVNIIVDKYVKNSVEPVNFQLFREVCERAVDGFAMMTEQWNFLFLSAKILTILNLTRREAGLFAVLMRKINKNEILLTKLRGKKEFVQLEGSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>X5MD71</accession>
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        <submittedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </submittedName>
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        <name evidence="10" type="ORF">CELE_Y51F10.4</name>
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    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CDO50123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PeptideAtlas" id="X5MD71"/>
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        <property type="protein sequence ID" value="CE49740"/>
        <property type="gene ID" value="WBGene00021765"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009020_3_0_1"/>
    <dbReference type="OrthoDB" id="513400at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021765">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="X5MD71">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF646">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="25"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDO50123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y51F10.4c"/>
        </source>
    </evidence>
    <sequence length="388" mass="42443" checksum="1B74B0A0EC2F0ABA" modified="2014-06-11" version="1">MMLESLPTIYDGEWSIHVVWWRPQGFLTCLPIVCMAMCCQTQLFPVLSCIKDATTDRVDYVVSNSINICAAMYAAVGVFGYVAFYSHELHGDVLVQFPPTIVTQSLKLAFLLSIAVSIPLMMFPARTALFCLILRDKESITHTVDLEKFTFHILTAVILLFNTILAILTPNVEFILGLTGAFIGSLVATILPSTIYIANQSASDKINRATRKVNEAAAATSSTAKMCLIIGLFILIASTCAILMGEKKTSVVEKPKAKDDSGEIRHEELKSLESLEEKVLDANLNISAKLDDISELAAKGNDTEAVKMLVEMKEQQKIQQELIVRQEQIVAQLNKKSEILANATAEGEAASEAAKIPEKLAPPENVETMEKEGKAAAESEKKAVNTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>X5MD76</accession>
    <name>X5MD76_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">spe-48</name>
        <name evidence="3" type="ORF">CELE_Y51F10.10</name>
        <name evidence="5" type="ORF">Y51F10.10</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDO50128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293400.1">
        <property type="nucleotide sequence ID" value="NM_001306471.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="X5MD76"/>
    <dbReference type="SMR" id="X5MD76"/>
    <dbReference type="GeneID" id="245997"/>
    <dbReference type="AGR" id="WB:WBGene00021771"/>
    <dbReference type="CTD" id="245997"/>
    <dbReference type="WormBase" id="Y51F10.10d">
        <property type="protein sequence ID" value="CE49639"/>
        <property type="gene ID" value="WBGene00021771"/>
        <property type="gene designation" value="spe-48"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5824432at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021771">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="X5MD76">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038870">
        <property type="entry name" value="UBAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960:SF5">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="273"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO50128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y51F10.10d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="X5MD76"/>
        </source>
    </evidence>
    <sequence length="322" mass="36365" checksum="0374A1EAB2226B08" modified="2014-06-11" version="1">MDISRKFYPTRNINVDFIQIPDLRFTKFEYSFEAETRAREQFDKQNEPIVLDSTSTKTTTTASPPGGNKNSGEVRTSESRQSVSGYDDVLSQNVLVPCPVNSNPSMTSSSTKPSVSNTSAMVHSLHEFESTNNVFDDIQILALDDRKALQEVLMLTNGSNTQLPQSTSSLSINHIQQQKQHEPINNNNNTEMKPKKLEKAEKTAKNSDQQQHEELRKRLLTKGYRADIVEKALRCLPKSRLVHIEYYMKACRTVEKTGKSSIDETLPFLIQCNLSDKMVILSYSEVCSNLLKMGFPRPQIFEAVAVEKGDQNRALSRLLPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BTI5</accession>
    <name>A0A078BTI5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y71F9B.2</name>
        <name evidence="2 4" type="ORF">Y71F9B.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293366.1">
        <property type="nucleotide sequence ID" value="NM_001306437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTI5"/>
    <dbReference type="SMR" id="A0A078BTI5"/>
    <dbReference type="GeneID" id="171836"/>
    <dbReference type="AGR" id="WB:WBGene00022126"/>
    <dbReference type="CTD" id="171836"/>
    <dbReference type="WormBase" id="Y71F9B.2b">
        <property type="protein sequence ID" value="CE50102"/>
        <property type="gene ID" value="WBGene00022126"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022126">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTI5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y71F9B.2b"/>
        </source>
    </evidence>
    <sequence length="42" mass="4867" checksum="735081CDAEA70285" modified="2014-10-29" version="1">MMWLRPLKPQSAESSDQSPCLKPRRTPSRPESPVQSSTVWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BTI7</accession>
    <name>A0A078BTI7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y71F9B.6</name>
        <name evidence="1 3" type="ORF">Y71F9B.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293371.1">
        <property type="nucleotide sequence ID" value="NM_001306442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTI7"/>
    <dbReference type="GeneID" id="260184"/>
    <dbReference type="AGR" id="WB:WBGene00022128"/>
    <dbReference type="CTD" id="260184"/>
    <dbReference type="WormBase" id="Y71F9B.6e">
        <property type="protein sequence ID" value="CE50107"/>
        <property type="gene ID" value="WBGene00022128"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5353095at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022128">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTI7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012388">
        <property type="entry name" value="CABLES1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896">
        <property type="entry name" value="CDK5 AND ABL1 ENZYME SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896:SF0">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDX47420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y71F9B.6e"/>
        </source>
    </evidence>
    <sequence length="60" mass="7156" checksum="868C4A7B77B75BF5" modified="2014-10-29" version="1">MNDYKKSTIKSYIEQAEDQLREPKSDLLAYELPICSVLQFRLQPTIDEIQPHVDRLQFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BTJ0</accession>
    <name>A0A078BTJ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mediator of RNA polymerase II transcription subunit 1.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">sop-3</name>
        <name evidence="2" type="ORF">CELE_Y71F9B.10</name>
        <name evidence="4" type="ORF">Y71F9B.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293376.1">
        <property type="nucleotide sequence ID" value="NM_001306447.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTJ0"/>
    <dbReference type="PeptideAtlas" id="A0A078BTJ0"/>
    <dbReference type="GeneID" id="171840"/>
    <dbReference type="AGR" id="WB:WBGene00004946"/>
    <dbReference type="CTD" id="171840"/>
    <dbReference type="WormBase" id="Y71F9B.10f">
        <property type="protein sequence ID" value="CE50001"/>
        <property type="gene ID" value="WBGene00004946"/>
        <property type="gene designation" value="sop-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5861512at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004946">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTJ0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y71F9B.10f"/>
        </source>
    </evidence>
    <sequence length="140" mass="15038" checksum="C54A3832AE8FD466" modified="2014-10-29" version="1">MYRDRSGGGGGSMRGGFPPASHYHGGTSGVNKQVASYAQGLPPGMGPPVVKPHGNNYQASQWVRPPTHRDSSHSYHGMPSLGPPQLQREPPAPPPPQMIPLPKDPPVLREHPREHRAHRGGADDDGPDSPEEGTLRIDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BTJ7</accession>
    <name>A0A078BTJ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">ccb-2</name>
        <name evidence="3" type="ORF">CELE_W10C8.1</name>
        <name evidence="5" type="ORF">W10C8.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293381.1">
        <property type="nucleotide sequence ID" value="NM_001306452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTJ7"/>
    <dbReference type="SMR" id="A0A078BTJ7"/>
    <dbReference type="GeneID" id="189330"/>
    <dbReference type="AGR" id="WB:WBGene00021125"/>
    <dbReference type="CTD" id="189330"/>
    <dbReference type="WormBase" id="W10C8.1b">
        <property type="protein sequence ID" value="CE50011"/>
        <property type="gene ID" value="WBGene00021125"/>
        <property type="gene designation" value="ccb-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5962384at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021125">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTJ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11863">
        <property type="entry name" value="SH3_CACNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="2">
        <location>
            <begin position="99"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W10C8.1b"/>
        </source>
    </evidence>
    <sequence length="383" mass="44717" checksum="E8F16BC94AED2E3A" modified="2014-10-29" version="1">MSMGALIGSRLWKQGCTYIHTRLIYLCRRIPRGYIFREKMHSVARENLQAYLHSYKLSSNEPGIKLMHNSQRDDQHRKDVEHFAALRALQHSKRKHVAFAVQAMRDYDGSLDEKSPLKDHTISFNTNDFIHIHTKFNSDWWIGRIVRSHSEFGFVPTARRLANYMVSDEDPPVKHNTSDHQDRSIWEPKCPYKVVPSSRPIVLLGPTLQHSRLTQLLHLALREEILKHFGKNMKYVKSDIGSGQQSGDRKGARWLRGLRDYDRGQDENQEVELIMRMTSKLHLLLVDSPHIHTPDDVQHLPLSPIFFLIRVSDNKILAKLLRNTGTTRMAAEIEVANVLKTMNDDRFEMVIEENGLREATRRIISYLEKYIHALHYHHKDDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BTK0</accession>
    <name>A0A078BTK0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">npr-4</name>
        <name evidence="14" type="ORF">C16D6.2</name>
        <name evidence="12" type="ORF">CELE_C16D6.2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294802.1">
        <property type="nucleotide sequence ID" value="NM_001307873.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTK0"/>
    <dbReference type="SMR" id="A0A078BTK0"/>
    <dbReference type="GeneID" id="182684"/>
    <dbReference type="KEGG" id="cel:CELE_C16D6.2"/>
    <dbReference type="AGR" id="WB:WBGene00007635"/>
    <dbReference type="CTD" id="182684"/>
    <dbReference type="WormBase" id="C16D6.2d">
        <property type="protein sequence ID" value="CE50035"/>
        <property type="gene ID" value="WBGene00007635"/>
        <property type="gene designation" value="npr-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007635">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTK0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000447">
        <property type="entry name" value="NeuroPeptide Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDX47440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="C16D6.2d"/>
        </source>
    </evidence>
    <sequence length="376" mass="42705" checksum="4835155ABAEF3641" modified="2014-10-29" version="1">MNGSDCLNLNSELWLYREDLSSRWYIMLVFAFLYLIIIAAGIIGNSCVILAITRNKSLQTVPNLFILSLSCSDIVVCCTSATITPITAFKKEWIFGEALCRIAPFIAGISLCFSTFTLTAISIDRYILIRFPMRKPITHYQAVGVIAIICAFAATITSPIMFKQKLGEFENFCGQYCTENWGANESQRKIYGAALMFLQLVIPLTIIIISYTAISLKIGQSMILKGAKKQKTDNWEMELSDQQRIAVKRRQRTNRMLIGMVVAFACSWIWSVTFNILRDYEYLPELIKTQEYIFGIATHCIAMTSTVWNPLLYAVLNLQLRAAFIDLMPHWLRRHLNLEGDNSSPLLNHPTMTITNKPSKQHTLIPAMDNHTCQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BTK3</accession>
    <name>A0A078BTK3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TSC22 domain family protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C30G4.4</name>
        <name evidence="3" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294807.1">
        <property type="nucleotide sequence ID" value="NM_001307878.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTK3"/>
    <dbReference type="SMR" id="A0A078BTK3"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4g">
        <property type="protein sequence ID" value="CE50025"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTK3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C30G4.4g"/>
        </source>
    </evidence>
    <sequence length="348" mass="38393" checksum="475144AF37C3D611" modified="2014-10-29" version="1">MAALFNESLRKVNEQQPPTIIEEDETPKRANRPPDLQGFSILDEKWRSSCSDDSDDSLPVGSYISTAEKPLRFCKSVDFRPLRREAPNLTGDSCSTLPSTPVHKKNPPLPTMSSGGSRFKQSESPINMLITHREMKCDMKSEPSLKVVPVETRDPYFSPNGKHAIAKPTAAIKKEEIVNRSSRSLSDIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKSVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BTK6</accession>
    <name>A0A078BTK6_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">TSC22 domain family protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C30G4.4</name>
        <name evidence="3" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294812.1">
        <property type="nucleotide sequence ID" value="NM_001307883.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTK6"/>
    <dbReference type="SMR" id="A0A078BTK6"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4l">
        <property type="protein sequence ID" value="CE50049"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTK6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C30G4.4l"/>
        </source>
    </evidence>
    <sequence length="220" mass="23990" checksum="FD5EC95CBACB4824" modified="2014-10-29" version="1">MSSGGSRFKVVPVETRDPYFSPNGKHAIAKPTAAIKKEEIVNRSSRSLSDIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKRAPLVRAKTVVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BTK9</accession>
    <name>A0A078BTK9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TSC22 domain family protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C30G4.4</name>
        <name evidence="2" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294817.1">
        <property type="nucleotide sequence ID" value="NM_001307888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTK9"/>
    <dbReference type="SMR" id="A0A078BTK9"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4q">
        <property type="protein sequence ID" value="CE50022"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTK9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C30G4.4q"/>
        </source>
    </evidence>
    <sequence length="98" mass="11144" checksum="8DE839F17277158B" modified="2014-10-29" version="1">MVAEANQSRRTKRAPLVRAKTVVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BTL3</accession>
    <name>A0A078BTL3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y105C5A.9</name>
        <name evidence="2 4" type="ORF">Y105C5A.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294098.1">
        <property type="nucleotide sequence ID" value="NM_001307169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTL3"/>
    <dbReference type="GeneID" id="190874"/>
    <dbReference type="KEGG" id="cel:CELE_Y105C5A.9"/>
    <dbReference type="AGR" id="WB:WBGene00013634"/>
    <dbReference type="CTD" id="190874"/>
    <dbReference type="WormBase" id="Y105C5A.9b">
        <property type="protein sequence ID" value="CE50062"/>
        <property type="gene ID" value="WBGene00013634"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10052254at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013634">
        <property type="expression patterns" value="Expressed in anatomical system and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTL3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y105C5A.9b"/>
        </source>
    </evidence>
    <sequence length="57" mass="6151" checksum="2F775ACD8743ECDC" modified="2014-10-29" version="1">MHILMPKMPKSKPGTVGNDMAGALAGRHDDEPPISSNYQGRPGNADPNYAYQPRADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BTL4</accession>
    <name>A0A078BTL4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine Rich Secreted Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y41E3.8</name>
        <name evidence="3 5" type="ORF">Y41E3.8</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001307173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTL4"/>
    <dbReference type="GeneID" id="178417"/>
    <dbReference type="KEGG" id="cel:CELE_Y41E3.8"/>
    <dbReference type="AGR" id="WB:WBGene00012766"/>
    <dbReference type="CTD" id="178417"/>
    <dbReference type="WormBase" id="Y41E3.8b">
        <property type="protein sequence ID" value="CE50028"/>
        <property type="gene ID" value="WBGene00012766"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167295at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012766">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTL4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024491">
        <property type="entry name" value="Se_SelK/SelG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10961">
        <property type="entry name" value="SelK_SelG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001730445" evidence="2">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y41E3.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BTL4"/>
        </source>
    </evidence>
    <sequence length="90" mass="8762" checksum="044CF21227289837" modified="2014-10-29" version="1">MIVGFFTFIMLFFRSLLGFTSPTNRNSNSQDYRNIVRGGGVNGAGGGGNAYRRNGGGGGGGGRNIGGLPTSSGVAPPPMGGGCCGGGGCG</sequence>
</entry>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="AGR" id="WB:WBGene00013530"/>
    <dbReference type="CTD" id="178432"/>
    <dbReference type="WormBase" id="Y73F8A.25d">
        <property type="protein sequence ID" value="CE50088"/>
        <property type="gene ID" value="WBGene00013530"/>
        <property type="gene designation" value="ntl-11"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013530">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0030014">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="559"/>
            <end position="609"/>
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    </feature>
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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            <begin position="571"/>
            <end position="597"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDX47473.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="Y73F8A.25d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BTL9"/>
        </source>
    </evidence>
    <sequence length="616" mass="69271" checksum="0C2F8DEC5D9D2D54" modified="2014-10-29" version="1"> </sequence>
</entry>
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    <name>A0A078BTM3_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Envelope glycoprotein UL132</fullName>
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        <name evidence="3 5" type="ORF">Y65A5A.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BTM3"/>
    <dbReference type="AGR" id="WB:WBGene00013419"/>
    <dbReference type="WormBase" id="Y65A5A.2c">
        <property type="protein sequence ID" value="CE50043"/>
        <property type="gene ID" value="WBGene00013419"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877695at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BTM3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y65A5A.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BTM3"/>
        </source>
    </evidence>
    <sequence length="187" mass="21184" checksum="DD1A3CD7AE6D590C" modified="2014-10-29" version="1">MFMDYDDDEISGNSTISADFRPREASKSGEKAENPYFLASTTVLPAVNHDGYVLPTDIDDIKNVEIPVETNQNSTMPTPLTHWSRWMQTASRFVDEYPNFSVLVISVLFAMLLFLICLVIAECVKSRRHHHRSVPRHHIPKSVTADLYNTSNCSHFYTKPTILLNQQEVTMQLITSDITVDCSSETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBS1</accession>
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        <submittedName>
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        <name evidence="4" type="ORF">T20C4.1</name>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="2 3" key="1">
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001309652.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBS1"/>
    <dbReference type="GeneID" id="191934"/>
    <dbReference type="AGR" id="WB:WBGene00005597"/>
    <dbReference type="CTD" id="191934"/>
    <dbReference type="WormBase" id="T20C4.1c">
        <property type="protein sequence ID" value="CE51292"/>
        <property type="gene ID" value="WBGene00005597"/>
        <property type="gene designation" value="srj-9"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5790586at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005597">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBS1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019423">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srj"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45907">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45907:SF15">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS J"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10319">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T20C4.1c"/>
        </source>
    </evidence>
    <sequence length="159" mass="18102" checksum="A8F126B98D349A52" modified="2016-05-11" version="1">MSNRCGFISLSYALLIIHFVYRYMALFHADKLPIFFQPLGIIISIIFLLMHAASWSVICQQCLAGNEEVREIISIDFLENFGANSKSLPMLAAIYYLAGNISAHSILLLRNVSLHYFGIQDNEENHVNAIDKQAQQKQHPSTKTTVSDINYPDVYPNHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBS2</accession>
    <name>A0A131MBS2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">aqp-3</name>
        <name evidence="10" type="ORF">CELE_Y69E1A.7</name>
        <name evidence="12" type="ORF">Y69E1A.7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CZR14534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309613.1">
        <property type="nucleotide sequence ID" value="NM_001322776.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBS2"/>
    <dbReference type="SMR" id="A0A131MBS2"/>
    <dbReference type="GeneID" id="190553"/>
    <dbReference type="AGR" id="WB:WBGene00000171"/>
    <dbReference type="CTD" id="190553"/>
    <dbReference type="WormBase" id="Y69E1A.7c">
        <property type="protein sequence ID" value="CE51447"/>
        <property type="gene ID" value="WBGene00000171"/>
        <property type="gene designation" value="aqp-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000171">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBS2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF27">
        <property type="entry name" value="AQUAPORIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CZR14534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y69E1A.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBS2"/>
        </source>
    </evidence>
    <sequence length="374" mass="41215" checksum="914A729B9BEB2482" modified="2016-05-11" version="1">MIFQGSPPFAVDRKSVDNSVVAVTDTPFEFAPSQKSSQHTNRPPPFVKPEEEMMYINHVERLKPKFAIGNELIRAFLAELFCTGFLVFGGECVNAQYVLSQGKNNEWIGISVGWGLVLMLAVLMGSKISGAHLNPAVSFFQLTQGKINLIRFLVYAVAQNIGAFLGAFGVFCVYYDAINVFEGGNRTVTGPTATASIFATYPGPFLGTFNAIVDQIAGTLVLCLGVAAITDRRNGIPAFLQPAWIGALLAFLGMSLALNAGYAINPARDFAPRLFNLCAGYGWEVFSYRNYKWFWIPIICPMIGGVLGAWLYEFFIGFHIQDEDAVSLDSESDKQLKTMIDNMVDIENQLPEYTDKKQLSDIASIHQNPSLRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBS5</accession>
    <name>A0A131MBS5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nephrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">syg-2</name>
        <name evidence="13" type="ORF">C26G2.1</name>
        <name evidence="11" type="ORF">CELE_C26G2.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CZR14604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309678.1">
        <property type="nucleotide sequence ID" value="NM_001322665.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBS5"/>
    <dbReference type="SMR" id="A0A131MBS5"/>
    <dbReference type="GeneID" id="181561"/>
    <dbReference type="AGR" id="WB:WBGene00007750"/>
    <dbReference type="CTD" id="181561"/>
    <dbReference type="WormBase" id="C26G2.1f">
        <property type="protein sequence ID" value="CE51320"/>
        <property type="gene ID" value="WBGene00007750"/>
        <property type="gene designation" value="syg-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007750">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBS5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:004602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:004604">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001273">
        <property type="entry name" value="Hibris, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="742"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="129"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="239"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="440"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="530"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="634"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CZR14604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C26G2.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBS5"/>
        </source>
    </evidence>
    <sequence length="928" mass="103234" checksum="E187ED6826570C91" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBT3</accession>
    <name>A0A131MBT3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">ugt-64</name>
        <name evidence="15" type="ORF">C07G3.9</name>
        <name evidence="13" type="ORF">CELE_C07G3.9</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309621.1">
        <property type="nucleotide sequence ID" value="NM_001322526.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBT3"/>
    <dbReference type="SMR" id="A0A131MBT3"/>
    <dbReference type="GeneID" id="178774"/>
    <dbReference type="KEGG" id="cel:CELE_C07G3.9"/>
    <dbReference type="AGR" id="WB:WBGene00015577"/>
    <dbReference type="CTD" id="178774"/>
    <dbReference type="WormBase" id="C07G3.9b">
        <property type="protein sequence ID" value="CE51421"/>
        <property type="gene ID" value="WBGene00015577"/>
        <property type="gene designation" value="ugt-64"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015577">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBT3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000118">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF62">
        <property type="entry name" value="GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CZR14544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="C07G3.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBT3"/>
        </source>
    </evidence>
    <sequence length="461" mass="53529" checksum="EDE90DAC50042B32" modified="2016-05-11" version="1">MHRLQKNDHTTALEMATYKPDIDFGMEERFINMSGFENNFISKDFFKIAFEDEFTFVHQAVPFIFGSISCDRILKHQKNRYLEIANENWDLFLSDSLFSPCGYAMAEITGKPHVMMHSSDVESAHGSFKGFSRNYAIMVPNFLPYSMSNFTIEKYWHRVVSTVDWFGSAFITGAVAGFAQKWALRSIIPFPFFSFYDYNRRSSFSFTDMPDPLYPVGARTNDYFSFGTYCTAQKKVLDEDWEQFVSDPKSKGTILVAFGTIIDWRFAPEEKFEIFLNTLNRLTEYRVIWSMKGDRPKGLGEHVKISSWVPQQQILNHKKTVLFLSHGGLKSVKEAVCSATPSLFMPMFAEQMRNAWLAKSKGFARILNKFHLSEQYLENHIREVVEHKSYQIQAEQFLSTFTDQPMPALDEAAFKFERLFKYNGKMPKFFYPKTIDLSYLTALNLDIWVIVPLVLGYIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBT4</accession>
    <name>A0A131MBT4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">phf-31</name>
        <name evidence="6" type="ORF">CELE_F13E6.3</name>
        <name evidence="8" type="ORF">F13E6.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CZR14614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368595.1">
        <property type="nucleotide sequence ID" value="NM_001381090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBT4"/>
    <dbReference type="GeneID" id="184417"/>
    <dbReference type="AGR" id="WB:WBGene00008747"/>
    <dbReference type="CTD" id="184417"/>
    <dbReference type="WormBase" id="F13E6.3b">
        <property type="protein sequence ID" value="CE51397"/>
        <property type="gene ID" value="WBGene00008747"/>
        <property type="gene designation" value="phf-31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008747">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBT4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="112"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CZR14614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F13E6.3b"/>
        </source>
    </evidence>
    <sequence length="159" mass="17724" checksum="74808ABEF98EA815" modified="2016-05-11" version="1">MHLIERASKVYKWTETADSIIVDDQFGTYISERISSWRKILAESREVVLSYPEDSDSDSPGPSSVDARKVPKSEAKKRGRENKKLVHNDSSENKEPSESPTADPTMKKPLWPCAVCNASAKFGSCKCKGCDQWSHLTCVGIKMKDFTEGWKCGACCAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBT5</accession>
    <name>A0A131MBT5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_T24A6.1</name>
        <name evidence="1 3" type="ORF">T24A6.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309662.1">
        <property type="nucleotide sequence ID" value="NM_001322535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBT5"/>
    <dbReference type="GeneID" id="188821"/>
    <dbReference type="AGR" id="WB:WBGene00020744"/>
    <dbReference type="CTD" id="188821"/>
    <dbReference type="WormBase" id="T24A6.1b">
        <property type="protein sequence ID" value="CE51538"/>
        <property type="gene ID" value="WBGene00020744"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020744">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBT5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CZR14587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T24A6.1b"/>
        </source>
    </evidence>
    <sequence length="26" mass="3028" checksum="F7BFACB5A63FA2FF" modified="2016-05-11" version="1">MRNDVKLLELSPIDAHFLRYRPSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBU4</accession>
    <name>A0A131MBU4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gag-pol polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F52D1.2</name>
        <name evidence="2 4" type="ORF">F52D1.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CZR14624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309696.1">
        <property type="nucleotide sequence ID" value="NM_001322609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBU4"/>
    <dbReference type="GeneID" id="186101"/>
    <dbReference type="AGR" id="WB:WBGene00018683"/>
    <dbReference type="CTD" id="186101"/>
    <dbReference type="WormBase" id="F52D1.2d">
        <property type="protein sequence ID" value="CE51506"/>
        <property type="gene ID" value="WBGene00018683"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10414678at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018683">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBU4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F52D1.2d"/>
        </source>
    </evidence>
    <sequence length="110" mass="12380" checksum="AB3406A32D0902BE" modified="2016-05-11" version="1">MNPAMDLIHEDLARASLLTDFNTKIDEFEHGFVNLGYVEKMNNTTKSKNLSGDFQRPRLSRQNAVVQERDSNSAMEKIKTKSCDTETSPVAKSPSSNMSSAKEERIIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBV3</accession>
    <name>A0A131MBV3_CAEEL</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="8 10" type="primary">coh-1</name>
        <name evidence="8" type="ORF">CELE_K08A8.3</name>
        <name evidence="10" type="ORF">K08A8.3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CZR14631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309701.1">
        <property type="nucleotide sequence ID" value="NM_001322623.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBV3"/>
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    <dbReference type="GeneID" id="181003"/>
    <dbReference type="AGR" id="WB:WBGene00000591"/>
    <dbReference type="CTD" id="181003"/>
    <dbReference type="WormBase" id="K08A8.3c">
        <property type="protein sequence ID" value="CE51307"/>
        <property type="gene ID" value="WBGene00000591"/>
        <property type="gene designation" value="coh-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000591">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBV3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000001">
        <property type="entry name" value="double-strand-break repair protein rad21 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="7">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CZR14631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="K08A8.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBV3"/>
        </source>
    </evidence>
    <sequence length="137" mass="15799" checksum="0941B05730606C30" modified="2016-05-11" version="1">MMDMPQSMDDINMVDDDVPQRNPLSPFAPMVEDEEMSPSEKRKKRDEEKEEPETDEDNRWSKRTHALLQNIATKLENQNGQVELDEMLKKGTSRKVAAAKFYSLLCLKKNQCIDIEQKEPYGDIMIKAGPNININTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBY2</accession>
    <name>A0A131MBY2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srt-39</name>
        <name evidence="2" type="ORF">CELE_W04D2.2</name>
        <name evidence="4" type="ORF">W04D2.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309669.1">
        <property type="nucleotide sequence ID" value="NM_001322589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBY2"/>
    <dbReference type="SMR" id="A0A131MBY2"/>
    <dbReference type="GeneID" id="189186"/>
    <dbReference type="AGR" id="WB:WBGene00012242"/>
    <dbReference type="CTD" id="189186"/>
    <dbReference type="WormBase" id="W04D2.2c">
        <property type="protein sequence ID" value="CE51388"/>
        <property type="gene ID" value="WBGene00012242"/>
        <property type="gene designation" value="srt-39"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873245at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012242">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBY2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="W04D2.2c"/>
        </source>
    </evidence>
    <sequence length="291" mass="33409" checksum="E467BAF5216302BB" modified="2016-05-11" version="1">MIDILYLPILSIIFEKDNFKMSCFKIMYLLGIIDFMITYVNSILTGWLAMKGAVYCTHPNIIYISGMVVCALWCSSCMTALLLVANRLLGMTKPSLAVKLFEGRKTYIALTFPILYFIYFLFTAPLVFNSKYLAWFYTPMIFDDGATEYFNHSHTINNFLIVTLTCVVYTPFRWVIGSNLKNVKNANASQLQNTKTQVFLQSTLICAANQVCAVIYVVMNVTEVPNWLIMFAHFTWEFIHGAPVFIYLALNRMIRERFLEKMHWMKGGALRETTSMMPIKKSVSTPVVIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBZ2</accession>
    <name>A0A131MBZ2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nephrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">syg-2</name>
        <name evidence="13" type="ORF">C26G2.1</name>
        <name evidence="11" type="ORF">CELE_C26G2.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CZR14605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380194.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBZ2"/>
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    <dbReference type="AGR" id="WB:WBGene00007750"/>
    <dbReference type="CTD" id="181561"/>
    <dbReference type="WormBase" id="C26G2.1g">
        <property type="protein sequence ID" value="CE51499"/>
        <property type="gene ID" value="WBGene00007750"/>
        <property type="gene designation" value="syg-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007750">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBZ2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:004604">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001273">
        <property type="entry name" value="Hibris, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
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            <begin position="29"/>
            <end position="124"/>
        </location>
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        <location>
            <begin position="129"/>
            <end position="221"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="9">
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            <end position="330"/>
        </location>
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            <end position="511"/>
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            <end position="711"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CZR14605.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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            <dbReference type="PeptideAtlas" id="A0A131MBZ2"/>
        </source>
    </evidence>
    <sequence length="915" mass="101626" checksum="0BF1006E039DDD19" modified="2016-05-11" version="1"> </sequence>
</entry>
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    <accession>A0A131MC59</accession>
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        </submittedName>
    </protein>
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        <name evidence="5" type="synonym">hpo-3</name>
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        <name evidence="5" type="ORF">F33D11.9</name>
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    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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        <property type="gene designation" value="gpaa-1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
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        <location>
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            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="660"/>
        </location>
    </feature>
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        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
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        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CZR14437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F33D11.9d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MC59"/>
        </source>
    </evidence>
    <sequence length="660" mass="74233" checksum="A01C6148953D86AC" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MC76</accession>
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        <recommendedName>
            <fullName evidence="2 6">Histone acetyltransferase</fullName>
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    <gene>
        <name evidence="9 11" type="primary">mys-2</name>
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    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 6"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CZR14447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317769.1">
        <property type="nucleotide sequence ID" value="NM_001330942.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MC76"/>
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    <dbReference type="GeneID" id="173281"/>
    <dbReference type="AGR" id="WB:WBGene00010537"/>
    <dbReference type="CTD" id="173281"/>
    <dbReference type="WormBase" id="K03D10.3d">
        <property type="protein sequence ID" value="CE51372"/>
        <property type="gene ID" value="WBGene00010537"/>
        <property type="gene designation" value="mys-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010537">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MC76">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF82">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="179"/>
        </location>
    </feature>
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        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
            <position position="3"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CZR14447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="K03D10.3d"/>
        </source>
    </evidence>
    <sequence length="179" mass="20660" checksum="B35E9116F133CB6B" modified="2016-05-11" version="1">MPEKPLSDLGKVSYRSYWWWRLMKLFHIHQGHTVTATFLSNESGIAVDDIVSTLITMRMCRQYKEPEFIPGEWYVRIHRKIVDHCVMCGYGKPPRLLLDRTKVRWAPAQTRPEFERQQQRTAAAMTSRRASKSQNVTPLVTPLATPPIEQKPEDTYTPSPLTDHHVATDAPDHISLPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4Q965</accession>
    <name>A0A8S4Q965_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">taf-1</name>
        <name evidence="11" type="ORF">CELE_W04A8.7</name>
        <name evidence="13" type="ORF">W04A8.7</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAH2122121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001391087.1">
        <property type="nucleotide sequence ID" value="NM_001404219.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="173257"/>
    <dbReference type="AGR" id="WB:WBGene00006382"/>
    <dbReference type="CTD" id="173257"/>
    <dbReference type="WormBase" id="W04A8.7b">
        <property type="protein sequence ID" value="CE54397"/>
        <property type="gene ID" value="WBGene00006382"/>
        <property type="gene designation" value="taf-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
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    <dbReference type="GO" id="GO:0017025">
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        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
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        <property type="entry name" value="Bromodomain_CS"/>
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        <property type="entry name" value="TAF1"/>
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        <property type="entry name" value="TAF1_HAT_dom"/>
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    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="TAF1_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
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        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
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    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1423"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1545"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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    <feature type="region of interest" description="Disordered" evidence="9">
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1664"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1712"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
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        <location>
            <begin position="1010"/>
            <end position="1024"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <end position="1091"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1184"/>
            <end position="1203"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1317"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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        <location>
            <begin position="1664"/>
            <end position="1692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH2122121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="W04A8.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4Q965"/>
        </source>
    </evidence>
    <sequence length="1742" mass="198325" checksum="C05D84CD53FE197A" modified="2022-10-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4Q999</accession>
    <name>A0A8S4Q999_CAEEL</name>
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        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
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        <name evidence="12 14" type="primary">lin-29</name>
        <name evidence="12" type="ORF">CELE_W03C9.4</name>
        <name evidence="14" type="ORF">W03C9.4</name>
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    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAH2168437.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="NP_001407498.1">
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        <property type="protein sequence ID" value="CE54396"/>
        <property type="gene ID" value="WBGene00003015"/>
        <property type="gene designation" value="lin-29"/>
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    <dbReference type="OrthoDB" id="6077919at2759"/>
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        <property type="component" value="Chromosome II"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="ZnF_C2H2"/>
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    <dbReference type="SUPFAM" id="SSF57667">
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="147"/>
            <end position="174"/>
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            <begin position="415"/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="16"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="53"/>
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        <location>
            <begin position="415"/>
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        <location>
            <begin position="438"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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            <dbReference type="EMBL" id="CAH2168437.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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        <source>
            <dbReference type="WormBase" id="W03C9.4d"/>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4Q999"/>
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    <sequence length="451" mass="49340" checksum="7EAE7A88364C48DE" modified="2022-10-12" version="1">MDQTVLDSAFNSPVDSGIAGTTTGSGSTTHFGVGTNLRSSSRSTDGTDSTDGANSDNVTGSTGSTPAHHSITNLNMALSQHSIDSATAASSTNPFPHFNQADLLNFHQNSLLPHHMFSQFGRYPQFEQKPDVGVLQQQMQMREAKPYKCTQCVKAFANSSYLSQHMRIHLGIKPFGPCNYCGKKFTQLSHLQQHIRTHTGEKPYKCKFTGCDKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFTDEQSLLDHIPKHKESKHLKIHICPFCGKSYTQQTYLQKHMTKHADRSKASNFGNDVVPADPFDPSLLSWNPMQGMGDNAHDSSSFNINQFAANTMIGSQSTNYNPAFQNSAFSQLFNIRNNRYLSEYPTSTKNGERAPGFNMITPLENIQRYNGSSSSATAVVTATGSAVVSSTPSSTSSSSAGSSSSQGGVFNPQSLINNMKNHSY</sequence>
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    <accession>B1Q257-2</accession>
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        <recommendedName>
            <fullName evidence="2">Isoform a of Receptor-type guanylate cyclase gcy-10</fullName>
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            <fullName evidence="6">Odorant response abnormal protein 1</fullName>
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        <name evidence="6" type="primary">odr-1</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
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            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1993" name="Cell" volume="74" first="515" last="527">
            <title>Odorant-selective genes and neurons mediate olfaction in C. elegans.</title>
            <authorList>
                <person name="Bargmann C.I."/>
                <person name="Hartwieg E."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="8348618"/>
            <dbReference type="DOI" id="10.1016/0092-8674(93)80053-H"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-647</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="1997" name="Proc. Natl. Acad. Sci. U.S.A." volume="94" first="3384" last="3387">
            <title>Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors.</title>
            <authorList>
                <person name="Yu S."/>
                <person name="Avery L."/>
                <person name="Baude E."/>
                <person name="Garbers D.L."/>
            </authorList>
            <dbReference type="PubMed" id="9096403"/>
            <dbReference type="DOI" id="10.1073/pnas.94.7.3384"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="1999" name="Cell" volume="99" first="387" last="398">
            <title>Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans.</title>
            <authorList>
                <person name="Troemel E.R."/>
                <person name="Sagasti A."/>
                <person name="Bargmann C.I."/>
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            <dbReference type="PubMed" id="10571181"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(00)81525-1"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2000" name="Neuron" volume="25" first="575" last="586">
            <title>Olfaction and odor discrimination are mediated by the C. elegans guanylyl cyclase ODR-1.</title>
            <authorList>
                <person name="L'Etoile N.D."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="10774726"/>
            <dbReference type="DOI" id="10.1016/S0896-6273(00)81061-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF GLU-904</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2010" name="Nat. Neurosci." volume="13" first="715" last="722">
            <title>C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog.</title>
            <authorList>
                <person name="Liu J."/>
                <person name="Ward A."/>
                <person name="Gao J."/>
                <person name="Dong Y."/>
                <person name="Nishio N."/>
                <person name="Inada H."/>
                <person name="Kang L."/>
                <person name="Yu Y."/>
                <person name="Ma D."/>
                <person name="Xu T."/>
                <person name="Mori I."/>
                <person name="Xie Z."/>
                <person name="Xu X.Z."/>
            </authorList>
            <dbReference type="PubMed" id="20436480"/>
            <dbReference type="DOI" id="10.1038/nn.2540"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003619" last="E1003619">
            <title>The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity.</title>
            <authorList>
                <person name="Krzyzanowski M.C."/>
                <person name="Brueggemann C."/>
                <person name="Ezak M.J."/>
                <person name="Wood J.F."/>
                <person name="Michaels K.L."/>
                <person name="Jackson C.A."/>
                <person name="Juang B.T."/>
                <person name="Collins K.D."/>
                <person name="Yu M.C."/>
                <person name="L'etoile N.D."/>
                <person name="Ferkey D.M."/>
            </authorList>
            <dbReference type="PubMed" id="23874221"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003619"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2014" name="J. Neurosci." volume="34" first="9389" last="9403">
            <title>Dissecting the signaling mechanisms underlying recognition and preference of food odors.</title>
            <authorList>
                <person name="Harris G."/>
                <person name="Shen Y."/>
                <person name="Ha H."/>
                <person name="Donato A."/>
                <person name="Wallis S."/>
                <person name="Zhang X."/>
                <person name="Zhang Y."/>
            </authorList>
            <dbReference type="PubMed" id="25009271"/>
            <dbReference type="DOI" id="10.1523/JNEUROSCI.0012-14.2014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="0" last="0">
            <title>The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition.</title>
            <authorList>
                <person name="DiTirro D."/>
                <person name="Philbrook A."/>
                <person name="Rubino K."/>
                <person name="Sengupta P."/>
            </authorList>
            <dbReference type="PubMed" id="31259686"/>
            <dbReference type="DOI" id="10.7554/elife.48789"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>B1Q257-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_057702 VSP_057703 VSP_057704"/>
        </isoform>
        <isoform>
            <id>B1Q257-1</id>
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        <property type="protein sequence ID" value="CE27430"/>
        <property type="gene ID" value="WBGene00003848"/>
        <property type="gene designation" value="odr-1"/>
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        <property type="component" value="Chromosome X"/>
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    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q19187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAF68380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="R01E6.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="R01E6.1b"/>
        </source>
    </evidence>
    <sequence length="1014" mass="115480" checksum="231697100AA6CDE4" modified="2009-09-22" version="2" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-01-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>D1MN51</accession>
    <name>D1MN51_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">unc-82</name>
        <name evidence="11" type="ORF">B0496.3</name>
        <name evidence="9" type="ORF">CELE_B0496.3</name>
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    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD62059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_501186.5">
        <property type="nucleotide sequence ID" value="NM_068785.5"/>
    </dbReference>
    <dbReference type="SMR" id="D1MN51"/>
    <dbReference type="PeptideAtlas" id="D1MN51"/>
    <dbReference type="GeneID" id="177514"/>
    <dbReference type="AGR" id="WB:WBGene00006814"/>
    <dbReference type="CTD" id="177514"/>
    <dbReference type="WormBase" id="B0496.3b">
        <property type="protein sequence ID" value="CE44280"/>
        <property type="gene ID" value="WBGene00006814"/>
        <property type="gene designation" value="unc-82"/>
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    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006814">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D1MN51">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
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    <dbReference type="GO" id="GO:0071688">
        <property type="term" value="P:striated muscle myosin thick filament assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061203">
        <property type="term" value="P:striated muscle paramyosin thick filament assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
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    <dbReference type="CDD" id="cd14073">
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    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.510.10:FF:000389">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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    <dbReference type="PANTHER" id="PTHR24346">
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    <dbReference type="PANTHER" id="PTHR24346:SF93">
        <property type="entry name" value="NUAK FAMILY SNF1-LIKE KINASE 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00069">
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    <dbReference type="PROSITE" id="PS50011">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="58"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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</entry>
<entry dataset="Swiss-Prot" created="2017-07-05" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="27978" last="27987">
            <title>Molecular cloning and functional expression of a Caenorhabditis elegans aminopeptidase structurally related to mammalian leukotriene A4 hydrolases.</title>
            <authorList>
                <person name="Abdel Baset H."/>
                <person name="Ford-Hutchinson A.W."/>
                <person name="O'Neill G.P."/>
            </authorList>
            <dbReference type="PubMed" id="9774412"/>
            <dbReference type="DOI" id="10.1074/jbc.273.43.27978"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EFT4-1</id>
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        </isoform>
        <isoform>
            <id>G5EFT4-2</id>
            <name evidence="7">b</name>
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        </isoform>
        <isoform>
            <id>G5EFT4-3</id>
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    <dbReference type="EC" id="3.4.11.6" evidence="3"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="AAC70927.1"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="8">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="27978" last="27987">
            <title>Molecular cloning and functional expression of a Caenorhabditis elegans aminopeptidase structurally related to mammalian leukotriene A4 hydrolases.</title>
            <authorList>
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                <person name="Ford-Hutchinson A.W."/>
                <person name="O'Neill G.P."/>
            </authorList>
            <dbReference type="PubMed" id="9774412"/>
            <dbReference type="DOI" id="10.1074/jbc.273.43.27978"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EFT4-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_058995"/>
        </isoform>
        <isoform>
            <id>G5EFT4-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EFT4-2</id>
            <name evidence="7">b</name>
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    <dbReference type="WormBase" id="C42C1.11c">
        <property type="protein sequence ID" value="CE33565"/>
        <property type="gene ID" value="WBGene00016589"/>
        <property type="gene designation" value="ltah-1.1"/>
    </dbReference>
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        <property type="component" value="Chromosome IV"/>
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        <source>
            <dbReference type="PubMed" id="9774412"/>
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    </evidence>
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    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="9774412"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAC70927.1"/>
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    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C42C1.11a"/>
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        </source>
    </evidence>
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            <dbReference type="WormBase" id="C42C1.11c"/>
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    <accession>H2KYH3-2</accession>
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            <fullName evidence="2">RING domain-containing protein spat-3</fullName>
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    <gene>
        <name evidence="5" type="primary">spat-3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Development" volume="136" first="943" last="953">
            <title>MIG-32 and SPAT-3A are PRC1 homologs that control neuronal migration in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Karakuzu O."/>
                <person name="Wang D.P."/>
                <person name="Cameron S."/>
            </authorList>
            <dbReference type="PubMed" id="19211678"/>
            <dbReference type="DOI" id="10.1242/dev.029363"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KYH3-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2KYH3-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_061241"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001024905.1">
        <property type="nucleotide sequence ID" value="NM_001029734.5"/>
    </dbReference>
    <dbReference type="WormBase" id="T13H2.5b">
        <property type="protein sequence ID" value="CE31236"/>
        <property type="gene ID" value="WBGene00020496"/>
        <property type="gene designation" value="spat-3"/>
    </dbReference>
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        <property type="component" value="Chromosome X"/>
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    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q99496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="19211678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T13H2.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T13H2.5b"/>
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    </evidence>
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    <accession>H2KYS3-2</accession>
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        <recommendedName>
            <fullName>Isoform b of 3-ketosteroid oxygenase</fullName>
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        <alternativeName>
            <fullName>Cytochrome P450 daf-9</fullName>
            <shortName evidence="3 4 5">DAF-9</shortName>
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    <gene>
        <name type="primary">daf-9</name>
        <name type="ORF">T13C5.1</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    <reference key="1">
        <citation type="journal article" date="1988" name="Dev. Biol." volume="126" first="270" last="293">
            <title>Mutants of Caenorhabditis elegans that form dauer-like larvae.</title>
            <authorList>
                <person name="Albert P.S."/>
                <person name="Riddle D.L."/>
            </authorList>
            <dbReference type="PubMed" id="3350212"/>
            <dbReference type="DOI" id="10.1016/0012-1606(88)90138-8"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Development" volume="129" first="221" last="231">
            <title>DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity.</title>
            <authorList>
                <person name="Jia K."/>
                <person name="Albert P.S."/>
                <person name="Riddle D.L."/>
            </authorList>
            <dbReference type="PubMed" id="11782415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Development" volume="130" first="3237" last="3248">
            <title>SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans.</title>
            <authorList>
                <person name="Ohkura K."/>
                <person name="Suzuki N."/>
                <person name="Ishihara T."/>
                <person name="Katsura I."/>
            </authorList>
            <dbReference type="PubMed" id="12783794"/>
            <dbReference type="DOI" id="10.1242/dev.00540"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Cell" volume="124" first="1209" last="1223">
            <title>Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.</title>
            <authorList>
                <person name="Motola D.L."/>
                <person name="Cummins C.L."/>
                <person name="Rottiers V."/>
                <person name="Sharma K.K."/>
                <person name="Li T."/>
                <person name="Li Y."/>
                <person name="Suino-Powell K."/>
                <person name="Xu H.E."/>
                <person name="Auchus R.J."/>
                <person name="Antebi A."/>
                <person name="Mangelsdorf D.J."/>
            </authorList>
            <dbReference type="PubMed" id="16529801"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.01.037"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Dev. Biol." volume="318" first="153" last="161">
            <title>Insulin-like signaling negatively regulates muscle arm extension through DAF-12 in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dixon S.J."/>
                <person name="Alexander M."/>
                <person name="Chan K.K."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="18436204"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2008.03.019"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="PLoS Biol." volume="10" first="E1001305" last="E1001305">
            <title>A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.</title>
            <authorList>
                <person name="Wollam J."/>
                <person name="Magner D.B."/>
                <person name="Magomedova L."/>
                <person name="Rass E."/>
                <person name="Shen Y."/>
                <person name="Rottiers V."/>
                <person name="Habermann B."/>
                <person name="Cummins C.L."/>
                <person name="Antebi A."/>
            </authorList>
            <dbReference type="PubMed" id="22505847"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.1001305"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2014" name="Genes Nutr." volume="9" first="414" last="414">
            <title>The zinc matrix metalloproteinase ZMP-2 increases survival of Caenorhabditis elegans through interference with lipoprotein absorption.</title>
            <authorList>
                <person name="Fischer M."/>
                <person name="Fitzenberger E."/>
                <person name="Kull R."/>
                <person name="Boll M."/>
                <person name="Wenzel U."/>
            </authorList>
            <dbReference type="PubMed" id="24957743"/>
            <dbReference type="DOI" id="10.1007/s12263-014-0414-6"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KYS3-1</id>
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        <isoform>
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            <sequence type="described" ref="VSP_045859"/>
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    <dbReference type="EC" id="1.14.14.-" evidence="1 2"/>
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    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="16529801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="22505847"/>
        </source>
    </evidence>
    <sequence length="557" mass="64771" checksum="2A84701C8AE6E75F" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-10-16" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>H2L008-2</accession>
    <name>ZTF16_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform a of Zinc finger protein ztf-16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">ztf-16</name>
        <name evidence="5" type="ORF">R08E3.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Dev. Biol." volume="339" first="51" last="64">
            <title>hunchback and Ikaros-like zinc finger genes control reproductive system development in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Large E.E."/>
                <person name="Mathies L.D."/>
            </authorList>
            <dbReference type="PubMed" id="20026024"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2009.12.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2012" name="Genetics" volume="190" first="1405" last="1415">
            <title>Sensory organ remodeling in Caenorhabditis elegans requires the zinc-finger protein ZTF-16.</title>
            <authorList>
                <person name="Procko C."/>
                <person name="Lu Y."/>
                <person name="Shaham S."/>
            </authorList>
            <dbReference type="PubMed" id="22298710"/>
            <dbReference type="DOI" id="10.1534/genetics.111.137786"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF 131-GLN--ALA-480 AND 236-ARG--ALA-480</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2L008-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_060359 VSP_060358"/>
        </isoform>
        <isoform>
            <id>H2L008-1</id>
            <name evidence="5">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024850.1">
        <property type="nucleotide sequence ID" value="NM_001029679.5"/>
    </dbReference>
    <dbReference type="WormBase" id="R08E3.4a">
        <property type="protein sequence ID" value="CE37662"/>
        <property type="gene ID" value="WBGene00019960"/>
        <property type="gene designation" value="ztf-16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="20026024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="R08E3.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="R08E3.4b"/>
        </source>
    </evidence>
    <sequence length="447" mass="50447" checksum="B52995E6EBA13DA1" modified="2012-03-21" version="1">MDELNACTECGFTTTVFSEFQGHIEKHENEHSRSSSGEMSNSQTIEWGDGIQSSTPSPRSTPPSDPTPSPDSDEHLEHHISITEITNTLIKKEPGTKGQKTVHVCPHCNFTTCMSQHMKSHLEAHERHQGQMYQCDICKMQFSQKANMHRHRMRHSGVKPYECRFCKKRFFRKDQMQEHSMTHIKTGFGFDCPVSQCNMQFSQHNALRAHLEETHTISSTNPASCKRCNLMFANSRRLLLHFQTRHDDSESSPKKENTPKRKKLSNGNALPMDPANMSITEQLQRMVKSEFSPPNTDTSDNSTSSEFDKIPPSFPMANPDILLMCLNQMNQFNGFGENIPRPMLNIPNIPLPALHNIPAVAAIVKQDQVQLWSEQTSSSVSVSAPSPSEQSHSPPANESSLSLTEKEKSPTPEKEDEENVVCVIANNNLLLKMSPFCLPFFEVQLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="168" xmlns="https://uniprot.org/uniprot">
    <accession>O18147</accession>
    <name>O18147_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">kel-3</name>
        <name evidence="4" type="ORF">CELE_T27E9.4</name>
        <name evidence="6" type="ORF">T27E9.4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAB04878.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T25373">
        <property type="entry name" value="T25373"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_499785.2">
        <property type="nucleotide sequence ID" value="NM_067384.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O18147"/>
    <dbReference type="SMR" id="O18147"/>
    <dbReference type="PeptideAtlas" id="O18147"/>
    <dbReference type="GeneID" id="176775"/>
    <dbReference type="UCSC" id="T27E9.4a.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00002185"/>
    <dbReference type="CTD" id="176775"/>
    <dbReference type="WormBase" id="T27E9.4a">
        <property type="protein sequence ID" value="CE29824"/>
        <property type="gene ID" value="WBGene00002185"/>
        <property type="gene designation" value="kel-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20684at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002185">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O18147">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="CDD" id="cd18247">
        <property type="entry name" value="BTB_POZ_KLHL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030603">
        <property type="entry name" value="KLHL18_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="51"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB04878.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="T27E9.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="O18147"/>
        </source>
    </evidence>
    <sequence length="589" mass="66596" checksum="90C47567E464538D" modified="2002-03-01" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-04-22" modified="2026-01-28" version="165" xmlns="https://uniprot.org/uniprot">
    <accession>O61866-2</accession>
    <name>LIPL5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Lipase lipl-5</fullName>
            <ecNumber evidence="3 4">3.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipase-like 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipl-5</name>
        <name evidence="6" type="ORF">ZK6.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2019" name="Biochim. Biophys. Acta" volume="1865" first="158539" last="158539">
            <title>Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Macedo F."/>
                <person name="Martins G.L."/>
                <person name="Luevano-Martinez L.A."/>
                <person name="Viana G.M."/>
                <person name="Riske K.A."/>
                <person name="Inague A."/>
                <person name="Yoshinaga M.Y."/>
                <person name="Aguilaniu H."/>
                <person name="Miyamoto S."/>
                <person name="Glezer I."/>
                <person name="da Cunha F.M."/>
            </authorList>
            <dbReference type="PubMed" id="31676440"/>
            <dbReference type="DOI" id="10.1016/j.bbalip.2019.158539"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2019" name="Cell Rep." volume="28" first="1041" last="1049.E4">
            <title>Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Buis A."/>
                <person name="Bellemin S."/>
                <person name="Goudeau J."/>
                <person name="Monnier L."/>
                <person name="Loiseau N."/>
                <person name="Guillou H."/>
                <person name="Aguilaniu H."/>
            </authorList>
            <dbReference type="PubMed" id="31340142"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2019.06.064"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O61866-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O61866-2</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_060546"/>
        </isoform>
        <isoform>
            <id>O61866-3</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_060545"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3 4"/>
    <dbReference type="RefSeq" id="NP_001368575.1">
        <property type="nucleotide sequence ID" value="NM_001380590.1"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK6.7c">
        <property type="protein sequence ID" value="CE50798"/>
        <property type="gene ID" value="WBGene00022642"/>
        <property type="gene designation" value="lipl-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="31340142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="31676440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZK6.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="ZK6.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="ZK6.7d"/>
        </source>
    </evidence>
    <sequence length="377" mass="42745" checksum="24D89958C94BCCC0" modified="1998-08-01" version="1" precursor="true">MTTPQIIERWGYPAMIYTVATDDGYILEMHRIPFGKTNVTWPNGKRPVVFMQHGLLCASSDWVVNLPDQSAGFLFADAGFDVWLGNMRGNTYSMKHKDLKPSHSAFWDWSWDEMATYDLNAMINHVLEVTGQDSVYYMGHSQGTLTMFSHLSKDDGSFAKKIKKFFALAPIGSVKHIKGFLSFFANYFSLEFDGWFDIFGAGEFLPNNWAMKLAAKDICGGLKVEADLCDNVLFLIAGPESDQWNQTRVPVYATHDPAGTSTQNIVHWMQMVHHGGVPAYDWGTKTNKKKYGQANPPEYDFTAIKGTKIYLYWSDADWLADTPDVPDYLLTRLNPAIVAQNNHLPDYNHLDFTWGLRAPDDIYRPAIKLCTDDYLGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-04-22" modified="2026-01-28" version="165" xmlns="https://uniprot.org/uniprot">
    <accession>O61866-3</accession>
    <name>LIPL5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of Lipase lipl-5</fullName>
            <ecNumber evidence="3 4">3.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipase-like 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipl-5</name>
        <name evidence="6" type="ORF">ZK6.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2019" name="Biochim. Biophys. Acta" volume="1865" first="158539" last="158539">
            <title>Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Macedo F."/>
                <person name="Martins G.L."/>
                <person name="Luevano-Martinez L.A."/>
                <person name="Viana G.M."/>
                <person name="Riske K.A."/>
                <person name="Inague A."/>
                <person name="Yoshinaga M.Y."/>
                <person name="Aguilaniu H."/>
                <person name="Miyamoto S."/>
                <person name="Glezer I."/>
                <person name="da Cunha F.M."/>
            </authorList>
            <dbReference type="PubMed" id="31676440"/>
            <dbReference type="DOI" id="10.1016/j.bbalip.2019.158539"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2019" name="Cell Rep." volume="28" first="1041" last="1049.E4">
            <title>Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Buis A."/>
                <person name="Bellemin S."/>
                <person name="Goudeau J."/>
                <person name="Monnier L."/>
                <person name="Loiseau N."/>
                <person name="Guillou H."/>
                <person name="Aguilaniu H."/>
            </authorList>
            <dbReference type="PubMed" id="31340142"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2019.06.064"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O61866-2</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_060546"/>
        </isoform>
        <isoform>
            <id>O61866-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O61866-3</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_060545"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3 4"/>
    <dbReference type="RefSeq" id="NP_001360404.1">
        <property type="nucleotide sequence ID" value="NM_001372991.2"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK6.7d">
        <property type="protein sequence ID" value="CE50743"/>
        <property type="gene ID" value="WBGene00022642"/>
        <property type="gene designation" value="lipl-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="31340142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="31676440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZK6.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="ZK6.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="ZK6.7d"/>
        </source>
    </evidence>
    <sequence length="327" mass="36951" checksum="53478C67E04D1DBF" modified="1998-08-01" version="1" precursor="true">MQHGLLCASSDWVVNLPDQSAGFLFADAGFDVWLGNMRGNTYSMKHKDLKPSHSAFWDWSWDEMATYDLNAMINHVLEVTGQDSVYYMGHSQGTLTMFSHLSKDDGSFAKKIKKFFALAPIGSVKHIKGFLSFFANYFSLEFDGWFDIFGAGEFLPNNWAMKLAAKDICGGLKVEADLCDNVLFLIAGPESDQWNQTRVPVYATHDPAGTSTQNIVHWMQMVHHGGVPAYDWGTKTNKKKYGQANPPEYDFTAIKGTKIYLYWSDADWLADTPDVPDYLLTRLNPAIVAQNNHLPDYNHLDFTWGLRAPDDIYRPAIKLCTDDYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2025-10-08" version="177" xmlns="https://uniprot.org/uniprot">
    <accession>O62276</accession>
    <name>O62276_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_F58G1.2</name>
        <name evidence="7 9" type="ORF">F58G1.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAB04525.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T22934">
        <property type="entry name" value="T22934"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254359.1">
        <property type="nucleotide sequence ID" value="NM_001267430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O62276"/>
    <dbReference type="SMR" id="O62276"/>
    <dbReference type="GeneID" id="174931"/>
    <dbReference type="UCSC" id="F58G1.2.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010264"/>
    <dbReference type="CTD" id="174931"/>
    <dbReference type="WormBase" id="F58G1.2a">
        <property type="protein sequence ID" value="CE35561"/>
        <property type="gene ID" value="WBGene00010264"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030063_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="PhylomeDB" id="O62276"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010264">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O62276">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB04525.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F58G1.2a"/>
        </source>
    </evidence>
    <sequence length="445" mass="51916" checksum="16EA584F858C1175" modified="2004-07-05" version="2">MKKETVAEANDSGRNDVCCPRKKLTGVGELLASLRNPPKIHKERIILGGDGRPIKKLRENRAALNFIDPSAELDKCIVRQKQQDFCAPDLNMVPASSLSIDEIRNAVRKSMFRCKVCKNRFGEMSLLERHLRDSHPKAYIAFLENQREMADYMGELERERNRIEELVSGGFIPPESEIEATSNNLEVDSIPLPGENSQGHIPRLNRYGGLMYPMDALRKKFPYLKKRSPQCPFCDKRFRNDISFNNHLTKKHPECAEFVQCLHCFKCLPSAADLPTHDCDLTYLCLDCRPIRNMCNGYRLFRHRTKFHRGYHSGFRCPDCNQKFLTPRKLRKHRKMAHVFSRTFQCHFCEEFFISDTAVTIHERVHTGILKFECTVCDFRASRYLQMEEHTKEHHGYMCSVCQLKCQHWNDIKDHMLAEHSCYVTEEASQVYIESPQIWLMYKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q18614</accession>
    <name>Q18614_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C44C10.9</name>
        <name evidence="3" type="ORF">CELE_C44C10.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAA93643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T19930">
        <property type="entry name" value="T19930"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_509961.1">
        <property type="nucleotide sequence ID" value="NM_077560.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18614"/>
    <dbReference type="SMR" id="Q18614"/>
    <dbReference type="PeptideAtlas" id="Q18614"/>
    <dbReference type="GeneID" id="3565088"/>
    <dbReference type="UCSC" id="C44C10.9a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008089"/>
    <dbReference type="CTD" id="3565088"/>
    <dbReference type="WormBase" id="C44C10.9a">
        <property type="protein sequence ID" value="CE18553"/>
        <property type="gene ID" value="WBGene00008089"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872847at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008089">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18614">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA93643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C44C10.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q18614"/>
        </source>
    </evidence>
    <sequence length="214" mass="24507" checksum="D43707F1A0619F96" modified="1998-11-01" version="2">MEIALQGDSKGILYEGYTKAFKQCIFEEGDVEGKNERYEFRCDYDLECCGRTCCIPQATTIPFWLMLILIALAIFLIALLLACLAYYLAKYLKSRPKKEKFIPSPMQETTLMMPKPVQITQRNEDEISRASVAQHVEPAPLSPQRAHNAFYRPFVADDVDDRDMPAPLRGSISYHSVNELTNSQFGTIKTIEKPKDRSSERMYKRPGFDNVPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q18632</accession>
    <name>Q18632_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C44H9.7</name>
        <name evidence="2" type="ORF">CELE_C44H9.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA99785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T19947">
        <property type="entry name" value="T19947"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023707.1">
        <property type="nucleotide sequence ID" value="NM_001028536.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18632"/>
    <dbReference type="GeneID" id="179762"/>
    <dbReference type="KEGG" id="cel:CELE_C44H9.7"/>
    <dbReference type="UCSC" id="C44H9.7b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008102"/>
    <dbReference type="CTD" id="179762"/>
    <dbReference type="WormBase" id="C44H9.7a">
        <property type="protein sequence ID" value="CE05423"/>
        <property type="gene ID" value="WBGene00008102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008102">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18632">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004186874" evidence="1">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA99785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C44H9.7a"/>
        </source>
    </evidence>
    <sequence length="269" mass="30532" checksum="2B444DA09AD64F3B" modified="1996-11-01" version="1">MYLTSLALLQVLGLPQNFTFYPLNNPFSIEYQSWQCQNLPSIYTQKYLKTKCPGLIGDLNVCCAVLNECLEQETENATCLTKYSTCTTAVFSLSHPSDLVACIRFPSDVLNNFANITVQPIPQIPKLRFITNNSSGSHELLEHCPNRSRTITTCLNNFQDEVTNMKKANPNSEKSQAFASVFGVAKLRARLEMFLRSENGKKCGNGIQDFLNNLEKSVSYKNKVAKMQDESLWKCGSNLLDNYASQVILGTKCYWLKGCYQQWIWINRK</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q19961</accession>
    <name>Q19961_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_F32D8.7</name>
        <name evidence="4 6" type="ORF">F32D8.7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA98452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21651">
        <property type="entry name" value="T21651"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_505779.1">
        <property type="nucleotide sequence ID" value="NM_073378.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19961"/>
    <dbReference type="SMR" id="Q19961"/>
    <dbReference type="GeneID" id="179511"/>
    <dbReference type="UCSC" id="F32D8.7b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009331"/>
    <dbReference type="CTD" id="179511"/>
    <dbReference type="WormBase" id="F32D8.7a">
        <property type="protein sequence ID" value="CE05786"/>
        <property type="gene ID" value="WBGene00009331"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_728130_0_0_1"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009331">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q19961">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="163"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA98452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F32D8.7a"/>
        </source>
    </evidence>
    <sequence length="378" mass="39263" checksum="F0BF35EC7BE25EE2" modified="1996-11-01" version="1">MVLRLCRFLMPSSSAGRCAKLFLLLLSVNSILIGLVASQLPDELDPFLEKLFDTSECEDFVTSSDYTNIATSKCDPHTCDFPRQICARPAAKFQDSSANICRTIPLECLTAANGGVAPGPSIRPPAPSPFIPQPSLPNIISSMLPAPSGGATPSPSTDPLAICKMGVPNGRFCGFRPMFTYNRETLQCDEFWFPGCRTAETNANLFEDYQQCQKIADLCKPTPAPTLAPFRPRPTTRRLPPPTTPPPPPPPPAPSPFVDAFKSFGGNNQAGQGALGALGMFTGSGLGPTGQGPLGNFSPNPNAGAAPNPGPAAGAGGPDGQDLGLFGLIQQGIMGAQAAGQGKGGKEAASKAAGQILQQFTGFDLGGIGNNFGGLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q19966</accession>
    <name>Q19966_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 70 homolog, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F32D8.5</name>
        <name evidence="3 5" type="ORF">F32D8.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM70 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA98457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21655">
        <property type="entry name" value="T21655"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_505777.1">
        <property type="nucleotide sequence ID" value="NM_073376.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19966"/>
    <dbReference type="PeptideAtlas" id="Q19966"/>
    <dbReference type="GeneID" id="179509"/>
    <dbReference type="UCSC" id="F32D8.5b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009330"/>
    <dbReference type="CTD" id="179509"/>
    <dbReference type="WormBase" id="F32D8.5a">
        <property type="protein sequence ID" value="CE05784"/>
        <property type="gene ID" value="WBGene00009330"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106429_0_0_1"/>
    <dbReference type="OrthoDB" id="156886at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009330">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q19966">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA98457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F32D8.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q19966"/>
        </source>
    </evidence>
    <sequence length="225" mass="24924" checksum="A6F27063471EF773" modified="1996-11-01" version="1">MSSLYALLRPIRISSSNFQKCVRSLGTTSKCNVEVLPLSKIDKDDLGHSILIHKGTLPPGSQKTPHDVVAMGVKGAKILSLSSSLAGVVMVPVLSSYLWEAAAERPSMMMFAIVANTFLVLLSFTPLLLHFLAKRFPIDIFYNNDKKVFTTVHYNFLMQKQALRFSASEVVDAAVAPEMKKVWIPLATAFVGKRPLLISLDRNAYLDKLAFDDLTKNVHIPPNHD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q20106-2</accession>
    <name>HRG4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Heme transporter hrg-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Heme-responsive gene 4 protein</fullName>
            <shortName>CeHRG-4</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hrg-4</name>
        <name evidence="2" type="ORF">F36H1.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Nature" volume="453" first="1127" last="1131">
            <title>Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.</title>
            <authorList>
                <person name="Rajagopal A."/>
                <person name="Rao A.U."/>
                <person name="Amigo J."/>
                <person name="Tian M."/>
                <person name="Upadhyay S.K."/>
                <person name="Hall C."/>
                <person name="Uhm S."/>
                <person name="Mathew M.K."/>
                <person name="Fleming M.D."/>
                <person name="Paw B.H."/>
                <person name="Krause M."/>
                <person name="Hamza I."/>
            </authorList>
            <dbReference type="PubMed" id="18418376"/>
            <dbReference type="DOI" id="10.1038/nature06934"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>HEME-BINDING</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2017" name="Nat. Cell Biol." volume="19" first="799" last="807">
            <title>Inter-organ signalling by HRG-7 promotes systemic haem homeostasis.</title>
            <authorList>
                <person name="Sinclair J."/>
                <person name="Pinter K."/>
                <person name="Samuel T."/>
                <person name="Beardsley S."/>
                <person name="Yuan X."/>
                <person name="Zhang J."/>
                <person name="Meng K."/>
                <person name="Yun S."/>
                <person name="Krause M."/>
                <person name="Hamza I."/>
            </authorList>
            <dbReference type="PubMed" id="28581477"/>
            <dbReference type="DOI" id="10.1038/ncb3539"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q20106-2</id>
            <name evidence="1">b</name>
            <sequence type="described" ref="VSP_058209"/>
        </isoform>
        <isoform>
            <id>Q20106-3</id>
            <name evidence="2">c</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001129857.1">
        <property type="nucleotide sequence ID" value="NM_001136385.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F36H1.5b">
        <property type="protein sequence ID" value="CE42667"/>
        <property type="gene ID" value="WBGene00009493"/>
        <property type="gene designation" value="hrg-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="F36H1.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F36H1.5c"/>
        </source>
    </evidence>
    <sequence length="169" mass="18979" checksum="36FC2EC56A6E5BD6" modified="2016-04-13" version="2">MTAENRGFCQLICHINVRIGWTIFGIVFGISAILTYAIKFHNWSATATTAIATLFACETLYLYWALKKNTIVNWKSSTFQLMIWPNVFIGLLGLLGCLVCYIIAGITHQGAGSIQAMYGENLWFTGSWSLVITKWTWQNAFFARKYLNKIGTASEDGDIDDDDVEVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q20913</accession>
    <name>Q20913_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">yif-1</name>
        <name evidence="11" type="ORF">CELE_F57A8.2</name>
        <name evidence="13" type="ORF">F57A8.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
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    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAA94831.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T22819"/>
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    </dbReference>
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    <dbReference type="KEGG" id="cel:CELE_F57A8.2"/>
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        <property type="organism name" value="c. elegans"/>
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        <property type="gene ID" value="WBGene00010178"/>
        <property type="gene designation" value="yif-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337750at2759"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="Yif1_fam"/>
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    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
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    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAA94831.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F57A8.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q20913"/>
        </source>
    </evidence>
    <sequence length="349" mass="39061" checksum="6CEFBA5ACB599FAC" modified="2002-10-01" version="2">MSNEWGNDWNTDSWNTGYSQPQQPSAPPAAPAAAPQDQSYGGGYYSQQSSNQGFDGYGQQSPTQNQYGGYGQQQQQQQSYGQNNGFGGFQPQQLMSDPMLNAAKQFGGQFAEQQKEKLTKYLGTFNLKYYFAVDNAYVGKKLGILFFPFFHKDWSLKFAGSADPAPAREDVNAPDLYIPLMSFLTYILVSGFVLGTQGRFSPEILGILTSNALIWVILENIVIFISKYILNISQSLSVWHSLAYSTYKFAHMIVCLLLFMVGDKTFYYGALAYSSLALVIFLLRSVSHFMFDSSGSYGSEEGRKRKLILVAFVVITQPLIMWWLTSTQIQSTAPRMVVGHEWLETNING</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>Q20928</accession>
    <name>Q20928_CAEEL</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="3 5" type="ORF">F57B7.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T22834"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256323.1">
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    </dbReference>
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    <dbReference type="GeneID" id="186438"/>
    <dbReference type="KEGG" id="cel:CELE_F57B7.2"/>
    <dbReference type="UCSC" id="F57B7.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010192"/>
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    <dbReference type="WormBase" id="F57B7.2a">
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        <property type="gene ID" value="WBGene00010192"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063761_0_0_1"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="PhylomeDB" id="Q20928"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010192">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q20928">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
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    <dbReference type="InterPro" id="IPR001283">
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    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
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    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="112"/>
            <end position="248"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA98491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F57B7.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q20928"/>
        </source>
    </evidence>
    <sequence length="289" mass="32806" checksum="FF9734BEDECE2282" modified="1996-11-01" version="1">MKRFFSRKKLRKSKSDFTGEKTDPERHEHENGAAGGVPLPTEPVPIPQSKSTNIVNNVSNSYGDDYEAVCSSIGEESRKNFDAQLDKHMMQTITDVKYMIKHSKYTALSEVNFQRSCLDAHNECRQRYGNENLCWSTELAEMAHAWAVKLADRGRVLYPELPGIGENLILKEANEQSHLPTGQEVIQEWEKEAQFFDFDKPRWNPKCQRFSQVVWKDTTELGAARYWNTANNCVAVVCFYRPAGNSNAPGEFASNVPSRDCSMSPIRNLGTQLKRHVTISTPERAVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="170" xmlns="https://uniprot.org/uniprot">
    <accession>Q20947</accession>
    <name>Q20947_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6 8" type="primary">bet-2</name>
        <name evidence="6" type="ORF">CELE_F57C7.1</name>
        <name evidence="8" type="ORF">F57C7.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAA93473.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T22845">
        <property type="entry name" value="T22845"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_509770.2">
        <property type="nucleotide sequence ID" value="NM_077369.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q20947"/>
    <dbReference type="SMR" id="Q20947"/>
    <dbReference type="STRING" id="6239.F57C7.1a.1"/>
    <dbReference type="PaxDb" id="6239-F57C7.1a.2"/>
    <dbReference type="PeptideAtlas" id="Q20947"/>
    <dbReference type="GeneID" id="181257"/>
    <dbReference type="UCSC" id="F57C7.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010199"/>
    <dbReference type="CTD" id="181257"/>
    <dbReference type="WormBase" id="F57C7.1a">
        <property type="protein sequence ID" value="CE31548"/>
        <property type="gene ID" value="WBGene00010199"/>
        <property type="gene designation" value="bet-2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ALKHKHS"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010199">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q20947">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd05497">
        <property type="entry name" value="Bromo_Brdt_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043508">
        <property type="entry name" value="Bromo_Brdt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF243">
        <property type="entry name" value="BROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RTN1-4"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="7">
        <location>
            <begin position="57"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
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            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
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            <dbReference type="EMBL" id="CAB01522.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="W06A7.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q23187"/>
        </source>
    </evidence>
    <sequence length="252" mass="27567" checksum="3AFCDF51434BCA3A" modified="2008-11-04" version="4">MSKLGAVGRGLYALIAFIVNIVLRVGLNVALVVGVAVSAHEAYKLTKSSGVLRKKEVLDVIYWRDAKKSAIVLSLALLVLFVLAKYPLLTVVTYSLLLALGAAAGFRVFKKVEAQIKKTDSEHPFSEILAQDLTLPQEKVHAQADVFVEHATCIANKLKKLVFVESPLESIKFGLVLWSLTYIASWFSGFTLAILGLLGVFSVPKVYESNQEAIDPHLATISGHLKNVQNIIDEKLPFLRSAPVAAEEKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q23188</accession>
    <name>Q23188_CAEEL</name>
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        </recommendedName>
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        <name evidence="10" type="ORF">W06A7.3</name>
    </gene>
    <organism evidence="8 9">
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        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="NP_506658.1">
        <property type="nucleotide sequence ID" value="NM_074257.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q23188"/>
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        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q23188"/>
    <dbReference type="GeneID" id="179981"/>
    <dbReference type="UCSC" id="W06A7.3b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004336"/>
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    <dbReference type="WormBase" id="W06A7.3b">
        <property type="protein sequence ID" value="CE14668"/>
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        <property type="gene designation" value="ret-1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q23188">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2480:FF:000002">
        <property type="entry name" value="Reticulon-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
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    <dbReference type="InterPro" id="IPR046964">
        <property type="entry name" value="RTN1-4"/>
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        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="56"/>
        </location>
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            <end position="171"/>
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            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB01523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="W06A7.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q23188"/>
        </source>
    </evidence>
    <sequence length="222" mass="24726" checksum="F8F16B157C45851E" modified="1996-11-01" version="1">MAQTRFVNKKYSKQPTWVPATDFPGKILDVIYWRDAKKSAIVLSLALLVLFVLAKYPLLTVVTYSLLLALGAAAGFRVFKKVEAQIKKTDSEHPFSEILAQDLTLPQEKVHAQADVFVEHATCIANKLKKLVFVESPLESIKFGLVLWSLTYIASWFSGFTLAILGLLGVFSVPKVYESNQEAIDPHLATISGHLKNVQNIIDEKLPFLRSAPVAAEEKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="154" xmlns="https://uniprot.org/uniprot">
    <accession>Q23193</accession>
    <name>Q23193_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HintN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hog-1</name>
        <name evidence="3" type="ORF">CELE_W06B11.4</name>
        <name evidence="5" type="ORF">W06B11.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T26220">
        <property type="entry name" value="T26220"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257029.1">
        <property type="nucleotide sequence ID" value="NM_001270100.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q23193"/>
    <dbReference type="SMR" id="Q23193"/>
    <dbReference type="MEROPS" id="C46.A08"/>
    <dbReference type="GeneID" id="180851"/>
    <dbReference type="UCSC" id="W06B11.4">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001984"/>
    <dbReference type="CTD" id="180851"/>
    <dbReference type="WormBase" id="W06B11.4a">
        <property type="protein sequence ID" value="CE35048"/>
        <property type="gene ID" value="WBGene00001984"/>
        <property type="gene designation" value="hog-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098767_0_0_1"/>
    <dbReference type="OrthoDB" id="5212at2759"/>
    <dbReference type="PhylomeDB" id="Q23193"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001984">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q23193">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001767">
        <property type="entry name" value="Hedgehog_Hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF7">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01079">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hint" evidence="2">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Hint" evidence="1">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD69463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W06B11.4a"/>
        </source>
    </evidence>
    <sequence length="195" mass="22360" checksum="2B11C72D4E7CEBC2" modified="2003-10-01" version="2">MTTPSGKKRMDQVGIGDLVLTGNLTATYYTPIITWMHREPENRYNFYTIMTEYGKMLAVSAKHLIYRNLCDENYAEYVKYLPKGRNVVYAEELKVGDCLVLLYKGKFRQQRVMRISITERKGIYAPITKNGRIIVNDIVASVFSGIKHTRLQSDYYSTIAYAQSWLWIFGETVFHKATIPIGSALASDVLRLVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q2XMY1</accession>
    <name>Q2XMY1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y41E3.7</name>
        <name evidence="4 6" type="ORF">Y41E3.7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ43917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041026.1">
        <property type="nucleotide sequence ID" value="NM_001047561.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2XMY1"/>
    <dbReference type="SMR" id="Q2XMY1"/>
    <dbReference type="PeptideAtlas" id="Q2XMY1"/>
    <dbReference type="GeneID" id="178416"/>
    <dbReference type="KEGG" id="cel:CELE_Y41E3.7"/>
    <dbReference type="UCSC" id="Y41E3.7a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012765"/>
    <dbReference type="CTD" id="178416"/>
    <dbReference type="WormBase" id="Y41E3.7b">
        <property type="protein sequence ID" value="CE39435"/>
        <property type="gene ID" value="WBGene00012765"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839451at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012765">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2XMY1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.680:FF:000006">
        <property type="entry name" value="Acyl-CoA binding domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.680:FF:000011">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052269">
        <property type="entry name" value="Golgi-PI4KB_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973:SF12">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13897">
        <property type="entry name" value="GOLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="231"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ43917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y41E3.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q2XMY1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45046" checksum="68B0C4F77C28407A" modified="2005-12-20" version="1">MADENHVRLSEVQLIQSEFGHSLEECYKLAVQYYKKEHVGKQEPVGYEDRIKLLSLSKQVQHGEISDEFDNAGWLDITGNDVKKDAELKEFAPQVTEQSAQPPSLQQVDQRLFEDQRKQIQEALNAQTFHQFSAYAQEQFPGQPEQQTTLIRQLQEQHYQQYMSQVYAQQSTTPNGAEMNPEESHQHQIRRDDDSDVSDDEAGEDLPSNPAISPASLWNRQDINEFKANIKKDGHEGIIKVGHGETVTVRVPTHENGSCLFWEFATDHYDIGFGVYFEWTVADSNQVSVHVSESDDEEDYDEALEAEQAEAGGGGGGAAGQGGPGDVEAGAMQTRRVDPNKPRQDEIIPVYRRDCHEEVYAGSHRYPGRGIYLLKFDNSYSLWRSKTLYYRVYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q2XMY3</accession>
    <name>Q2XMY3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trichohyalin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_W08G11.3</name>
        <name evidence="3 5" type="ORF">W08G11.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAJ43914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041180.1">
        <property type="nucleotide sequence ID" value="NM_001047715.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2XMY3"/>
    <dbReference type="SMR" id="Q2XMY3"/>
    <dbReference type="IntAct" id="Q2XMY3">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="6239.W08G11.3b.1"/>
    <dbReference type="PaxDb" id="6239-W08G11.3b"/>
    <dbReference type="GeneID" id="189304"/>
    <dbReference type="UCSC" id="W08G11.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012347"/>
    <dbReference type="CTD" id="189304"/>
    <dbReference type="WormBase" id="W08G11.3b">
        <property type="protein sequence ID" value="CE39424"/>
        <property type="gene ID" value="WBGene00012347"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502T1QZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RKNNDEW"/>
    <dbReference type="OrthoDB" id="5877542at2759"/>
    <dbReference type="PhylomeDB" id="Q2XMY3"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012347">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2XMY3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ43914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W08G11.3b"/>
        </source>
    </evidence>
    <sequence length="511" mass="58282" checksum="1DA9E2929B71F2BD" modified="2005-12-20" version="1">MDSGRRSRSGSRDRDSRRRHKKVHRHKRRSRTRSRSRSYERNGTAGIHINPAFGLPPGTVQPQPMGYSASQLLQTNNMLEAEIHRLKAALNAAQGGQQIEAQRCQMLQQELRNAQIQRDQANKRCNEIMSERRMMNDSKVEMANRINGLEVANRMLRDDVTQARNATEAKEEEIRAITYQSEIVRQQINALNERNAALKTKCETVVAQNRQQHEEMEARQKFVQGAQLNVKKAEADLQLANAEIQRLLRELDSSQQLENSSITDKRNIEEELIRKEDEIRLANYKSATLLKAANDKIEKLELRLKQEKPAVHNEMTVETIYIAIETIKTTYEKQLSRMEEEIEHLKAEKLKQEQQQIMMEEEEDAVVQNLEELPAYLKTPMRPDPTKMEGLKKTIQVKIRLDEEPERPARPASGPPVDSPVTWHQRKPFERLPAMVVPLFGTTEAPSTGPGPSISSEDLITSSTIESTSDEISIAACNQFSEEDLLLAEPTDMISPSQLLDLDEQTLLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q2XMY4</accession>
    <name>Q2XMY4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trichohyalin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_W08G11.3</name>
        <name evidence="3 5" type="ORF">W08G11.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAJ43913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041179.1">
        <property type="nucleotide sequence ID" value="NM_001047714.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2XMY4"/>
    <dbReference type="SMR" id="Q2XMY4"/>
    <dbReference type="IntAct" id="Q2XMY4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="189304"/>
    <dbReference type="KEGG" id="cel:CELE_W08G11.3"/>
    <dbReference type="UCSC" id="W08G11.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012347"/>
    <dbReference type="CTD" id="189304"/>
    <dbReference type="WormBase" id="W08G11.3a">
        <property type="protein sequence ID" value="CE39423"/>
        <property type="gene ID" value="WBGene00012347"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534468_0_0_1"/>
    <dbReference type="OrthoDB" id="5877542at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012347">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2XMY4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ43913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W08G11.3a"/>
        </source>
    </evidence>
    <sequence length="510" mass="58183" checksum="3073610008AECD43" modified="2005-12-20" version="1">MDSGRRSRSGSRDRDSRRRHKKHRHKRRSRTRSRSRSYERNGTAGIHINPAFGLPPGTVQPQPMGYSASQLLQTNNMLEAEIHRLKAALNAAQGGQQIEAQRCQMLQQELRNAQIQRDQANKRCNEIMSERRMMNDSKVEMANRINGLEVANRMLRDDVTQARNATEAKEEEIRAITYQSEIVRQQINALNERNAALKTKCETVVAQNRQQHEEMEARQKFVQGAQLNVKKAEADLQLANAEIQRLLRELDSSQQLENSSITDKRNIEEELIRKEDEIRLANYKSATLLKAANDKIEKLELRLKQEKPAVHNEMTVETIYIAIETIKTTYEKQLSRMEEEIEHLKAEKLKQEQQQIMMEEEEDAVVQNLEELPAYLKTPMRPDPTKMEGLKKTIQVKIRLDEEPERPARPASGPPVDSPVTWHQRKPFERLPAMVVPLFGTTEAPSTGPGPSISSEDLITSSTIESTSDEISIAACNQFSEEDLLLAEPTDMISPSQLLDLDEQTLLGGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ZEP9-2</accession>
    <name>NFYA2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Nuclear transcription factor Y subunit nfya-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">CAAT box DNA-binding protein subunit nfya-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nfya-2</name>
        <name evidence="3" type="ORF">Y53H1A.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2005" name="J. Mol. Histol." volume="36" first="139" last="145">
            <title>Expression of the CCAAT-binding factor NF-Y in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Franchini A."/>
                <person name="Imbriano C."/>
                <person name="Peruzzi E."/>
                <person name="Mantovani R."/>
                <person name="Ottaviani E."/>
            </authorList>
            <dbReference type="PubMed" id="15704008"/>
            <dbReference type="DOI" id="10.1007/s10735-004-6017-6"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2007" name="Dev. Biol." volume="308" first="583" last="592">
            <title>Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5.</title>
            <authorList>
                <person name="Deng H."/>
                <person name="Sun Y."/>
                <person name="Zhang Y."/>
                <person name="Luo X."/>
                <person name="Hou W."/>
                <person name="Yan L."/>
                <person name="Chen Y."/>
                <person name="Tian E."/>
                <person name="Han J."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="17574230"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.05.021"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN NF-Y COMPLEX</scope>
        <scope>INTERACTION WITH NFYB-1 AND NFYC-2</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2013" name="Dev. Biol." volume="382" first="38" last="47">
            <title>The NF-Y complex negatively regulates Caenorhabditis elegans tbx-2 expression.</title>
            <authorList>
                <person name="Milton A.C."/>
                <person name="Packard A.V."/>
                <person name="Clary L."/>
                <person name="Okkema P.G."/>
            </authorList>
            <dbReference type="PubMed" id="23933492"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2013.08.001"/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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    </evidence>
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    <accession>Q5ZEP9-3</accession>
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        <recommendedName>
            <fullName evidence="1">Isoform c of Nuclear transcription factor Y subunit nfya-2</fullName>
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            <fullName evidence="1">CAAT box DNA-binding protein subunit nfya-2</fullName>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2005" name="J. Mol. Histol." volume="36" first="139" last="145">
            <title>Expression of the CCAAT-binding factor NF-Y in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Franchini A."/>
                <person name="Imbriano C."/>
                <person name="Peruzzi E."/>
                <person name="Mantovani R."/>
                <person name="Ottaviani E."/>
            </authorList>
            <dbReference type="PubMed" id="15704008"/>
            <dbReference type="DOI" id="10.1007/s10735-004-6017-6"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2007" name="Dev. Biol." volume="308" first="583" last="592">
            <title>Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5.</title>
            <authorList>
                <person name="Deng H."/>
                <person name="Sun Y."/>
                <person name="Zhang Y."/>
                <person name="Luo X."/>
                <person name="Hou W."/>
                <person name="Yan L."/>
                <person name="Chen Y."/>
                <person name="Tian E."/>
                <person name="Han J."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="17574230"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.05.021"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN NF-Y COMPLEX</scope>
        <scope>INTERACTION WITH NFYB-1 AND NFYC-2</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2013" name="Dev. Biol." volume="382" first="38" last="47">
            <title>The NF-Y complex negatively regulates Caenorhabditis elegans tbx-2 expression.</title>
            <authorList>
                <person name="Milton A.C."/>
                <person name="Packard A.V."/>
                <person name="Clary L."/>
                <person name="Okkema P.G."/>
            </authorList>
            <dbReference type="PubMed" id="23933492"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2013.08.001"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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            <id>Q5ZEP9-2</id>
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            <sequence type="described" ref="VSP_060605"/>
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            <id>Q5ZEP9-3</id>
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            <sequence type="described" ref="VSP_060604"/>
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            <id>Q5ZEP9-1</id>
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    </dbReference>
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            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y53H1A.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y53H1A.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y53H1A.5c"/>
        </source>
    </evidence>
    <sequence length="132" mass="15148" checksum="1B6C6220ECC062F7" modified="2007-07-10" version="2">MVNPRQYKRIIKRREMRQKMEDSGRLPLERQKYMHESRRQHALKRRRTGGRFDANAEAAAASSEPSISSAAPSPPKAPRAPTTYAMIRPATSHPPVNIPKAPAMTYRPVQEEKKSIERISKAQMFTIPKRQQ</sequence>
</entry>
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    <accession>Q6A2D2</accession>
    <name>Q6A2D2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">hpo-34</name>
        <name evidence="2" type="ORF">CELE_F29G6.3</name>
        <name evidence="4" type="ORF">F29G6.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAH10796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024614.1">
        <property type="nucleotide sequence ID" value="NM_001029443.6"/>
    </dbReference>
    <dbReference type="IntAct" id="Q6A2D2">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q6A2D2"/>
    <dbReference type="GeneID" id="181340"/>
    <dbReference type="KEGG" id="cel:CELE_F29G6.3"/>
    <dbReference type="UCSC" id="F29G6.3c.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009259"/>
    <dbReference type="CTD" id="181340"/>
    <dbReference type="WormBase" id="F29G6.3c">
        <property type="protein sequence ID" value="CE36484"/>
        <property type="gene ID" value="WBGene00009259"/>
        <property type="gene designation" value="hpo-34"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_266701_0_0_1"/>
    <dbReference type="OrthoDB" id="5823380at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009259">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6A2D2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH10796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F29G6.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q6A2D2"/>
        </source>
    </evidence>
    <sequence length="1453" mass="164860" checksum="2AE5896F72DF6CA8" modified="2004-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q86GU1</accession>
    <name>Q86GU1_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
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    <gene>
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        <name evidence="6" type="ORF">C09B8.6</name>
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    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
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    <dbReference type="AlphaFoldDB" id="Q86GU1"/>
    <dbReference type="SMR" id="Q86GU1"/>
    <dbReference type="PeptideAtlas" id="Q86GU1"/>
    <dbReference type="GeneID" id="180872"/>
    <dbReference type="UCSC" id="C09B8.6c.3">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00002023"/>
    <dbReference type="CTD" id="180872"/>
    <dbReference type="WormBase" id="C09B8.6b">
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        <property type="gene ID" value="WBGene00002023"/>
        <property type="gene designation" value="hsp-25"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091813_1_0_1"/>
    <dbReference type="OrthoDB" id="10060792at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002023">
        <property type="expression patterns" value="Expressed in larva and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86GU1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BMA-HSP-25, isoform c"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="106"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD63802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C09B8.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q86GU1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23491" checksum="3A9AD9488EE2556F" modified="2003-06-01" version="1">MSERRIDVNRSNYSVIDNEFGNMRDRFEQEMRRVEEEMKRLRSEFEGYRPNGGPPAAISNQPYNAYSNTSSHHETSNRTGGFGSPLPPPSFHGPSDLMAHRPTYDPYLDNLKSPLIKDESDGKTLRLRFDVANYKPEEVTVKTIDNRLLVHAKHEEKTPQRTVFREYNQEFLLPRGTNPEQISSTLSTDGVLTVEAPLPQLAIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q86GU3</accession>
    <name>Q86GU3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alanine transaminase</fullName>
            <ecNumber evidence="8">2.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="ORF">C32F10.8</name>
        <name evidence="11" type="ORF">CELE_C32F10.8</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-alanine + 2-oxoglutarate = pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:19453"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="8"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD61913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370337.1">
        <property type="nucleotide sequence ID" value="NM_001383155.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86GU3"/>
    <dbReference type="SMR" id="Q86GU3"/>
    <dbReference type="PeptideAtlas" id="Q86GU3"/>
    <dbReference type="GeneID" id="172252"/>
    <dbReference type="UCSC" id="C32F10.8b.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016333"/>
    <dbReference type="CTD" id="172252"/>
    <dbReference type="WormBase" id="C32F10.8b">
        <property type="protein sequence ID" value="CE33563"/>
        <property type="gene ID" value="WBGene00016333"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014254_0_0_1"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016333">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86GU3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="126"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD61913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C32F10.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q86GU3"/>
        </source>
    </evidence>
    <sequence length="350" mass="38677" checksum="6F315698A942233C" modified="2003-06-01" version="1">MRTVQAISGLVTSRFFGTSTRIMASGKTLNTSNINPNVIKMEYAVRGPIVIRAVELEKELATGAQKPFPNVIKANIGDAHAMGQKPITFIRQLLACIVNPEIMKTDKSIPSDVIEHANAFLGSCGGKSAGAYSQSTGVEIVRKHVAEYIKRRDGGIPCNSEDVCLSGGASESIRNVLKLFINHNNAKKVGVMIPIPQYPLYSATIEEFGLGQVGYYLSESSNWSMDEAELERSFNDHCKEYDIRVLCIINPGNPTGQALSRENIETIIKFAQKKNLFLMADEVYQDNVYAQGSQFHSFKKVLVEMGEPYNKMELASFHSVSKGYMGECGMRGGYVEFLNLDPEVTRTSRH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I136-2</accession>
    <name>GALT4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Polypeptide N-acetylgalactosaminyltransferase 4</fullName>
            <shortName>pp-GaNTase 4</shortName>
            <ecNumber>2.4.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Protein-UDP acetylgalactosaminyltransferase 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">gly-4</name>
        <name type="ORF">Y116F11B.12</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="8268" last="8277">
            <title>cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hagen F.K."/>
                <person name="Nehrke K."/>
            </authorList>
            <dbReference type="PubMed" id="9525933"/>
            <dbReference type="DOI" id="10.1074/jbc.273.14.8268"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>ENZYME ACTIVITY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q8I136-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q8I136-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_011236 VSP_011237"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.4.1.41"/>
    <dbReference type="RefSeq" id="NP_001379271.1">
        <property type="nucleotide sequence ID" value="NM_001392704.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y116F11B.12b">
        <property type="protein sequence ID" value="CE32074"/>
        <property type="gene ID" value="WBGene00001629"/>
        <property type="gene designation" value="gly-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="453" mass="51879" checksum="572763F5D4D25B53" modified="2004-08-16" version="2">MLPRMLKMKTVGTVLAVIWLFGLAFIYVQSTSSSLRPPGRHPPPLPQLDPLIPQNPPQNDEIRPKKSAPPIPTINLAEDTTIHERTEKDVTWKTFDVEKFLNKGKWHQGEDKYKANSFNQEASDALNPTRKIPDSREPQCRDVDYSKVGMQPTTVIITYHNEARSSLLRTVFSVFNQSPEELLLEIVLVDDNSQDVEIGKELAQIQRITVLRNNQREGLIRSRVKGAQVARAPVLTFLDSHIECNQKWLEPLLARIAENPKAVVAPIIDVINVDNFNYVGASADLRGGFDWTLVFRWEFMNEQLRKERHAHPTAPIRSPTMAGGLFAISKEWFNELGTYDLDMEVWGGENLEMSFRVWQCGGSLEIMPCSRVGHVFRKKHPYTFPGGSGNVFQKNTRRAAEVWMDEYKAIYLKNVPSARFVNFGDITDRLAIRDRLQCKSFKWYLENVYPQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TZC8</accession>
    <name>Q9TZC8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytosolic purine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ntfc-1</name>
        <name evidence="8" type="ORF">CELE_Y71H10B.1</name>
        <name evidence="10" type="ORF">Y71H10B.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T33570">
        <property type="entry name" value="T33570"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379633.1">
        <property type="nucleotide sequence ID" value="NM_001392738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9TZC8"/>
    <dbReference type="SMR" id="Q9TZC8"/>
    <dbReference type="PeptideAtlas" id="Q9TZC8"/>
    <dbReference type="GeneID" id="180573"/>
    <dbReference type="UCSC" id="Y71H10B.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022201"/>
    <dbReference type="CTD" id="180573"/>
    <dbReference type="WormBase" id="Y71H10B.1a">
        <property type="protein sequence ID" value="CE29140"/>
        <property type="gene ID" value="WBGene00022201"/>
        <property type="gene designation" value="ntfc-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017845_3_1_1"/>
    <dbReference type="OrthoDB" id="10252832at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022201">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9TZC8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07522">
        <property type="entry name" value="HAD_cN-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000255">
        <property type="entry name" value="Protein CBG02038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF15">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD63463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y71H10B.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q9TZC8"/>
        </source>
    </evidence>
    <sequence length="556" mass="64281" checksum="38DA8BF1CF5852EB" modified="2001-10-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TZD3</accession>
    <name>Q9TZD3_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_R160.5</name>
        <name evidence="2 4" type="ORF">R160.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD68423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T33565">
        <property type="entry name" value="T33565"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257010.1">
        <property type="nucleotide sequence ID" value="NM_001270081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9TZD3"/>
    <dbReference type="SMR" id="Q9TZD3"/>
    <dbReference type="GeneID" id="187914"/>
    <dbReference type="UCSC" id="R160.5">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020122"/>
    <dbReference type="CTD" id="187914"/>
    <dbReference type="WormBase" id="R160.5a">
        <property type="protein sequence ID" value="CE19555"/>
        <property type="gene ID" value="WBGene00020122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020122">
        <property type="expression patterns" value="Expressed in multicellular organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9TZD3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD68423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R160.5a"/>
        </source>
    </evidence>
    <sequence length="102" mass="11426" checksum="AFD366C3932EB26C" modified="2000-05-01" version="1">MLPFFKNPAIQFAFVVILVCALAVCICMLIERADGFFCPLPPEELRRIVNTIPPRTPIAAPVNRCQVVIKIDPTESDVDMTSENETPILGYESDEFDQTINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TZH0</accession>
    <name>Q9TZH0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nhx-6</name>
        <name evidence="13" type="ORF">CELE_F58E1.6</name>
        <name evidence="15" type="ORF">F58E1.6</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD71271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T33528">
        <property type="entry name" value="T33528"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022214.1">
        <property type="nucleotide sequence ID" value="NM_001027043.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9TZH0"/>
    <dbReference type="SMR" id="Q9TZH0"/>
    <dbReference type="GeneID" id="186511"/>
    <dbReference type="KEGG" id="cel:CELE_F58E1.6"/>
    <dbReference type="UCSC" id="F58E1.6a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003734"/>
    <dbReference type="CTD" id="186511"/>
    <dbReference type="WormBase" id="F58E1.6a">
        <property type="protein sequence ID" value="CE33115"/>
        <property type="gene ID" value="WBGene00003734"/>
        <property type="gene designation" value="nhx-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_4_3_1"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003734">
        <property type="expression patterns" value="Expressed in adult organism"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9TZH0">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF92">
        <property type="entry name" value="NA(+)_H(+) EXCHANGER PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004334042" description="Sodium/hydrogen exchanger" evidence="11">
        <location>
            <begin position="24"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="59"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD71271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F58E1.6a"/>
        </source>
    </evidence>
    <sequence length="538" mass="60595" checksum="82106F43F53C8390" modified="2003-03-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2025-10-08" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TZH1</accession>
    <name>Q9TZH1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M14 carboxypeptidase A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CELE_T06A4.1</name>
        <name evidence="9 11" type="ORF">T06A4.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD73365.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T33527">
        <property type="entry name" value="T33527"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9TZH1"/>
    <dbReference type="SMR" id="Q9TZH1"/>
    <dbReference type="MEROPS" id="M14.A22"/>
    <dbReference type="UCSC" id="T06A4.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020281"/>
    <dbReference type="WormBase" id="T06A4.1a">
        <property type="protein sequence ID" value="CE52652"/>
        <property type="gene ID" value="WBGene00020281"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019326_2_1_1"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020281">
        <property type="expression patterns" value="Expressed in anatomical system and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9TZH1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000208">
        <property type="entry name" value="Protein CBG05161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF133">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="8">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="301"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD73365.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="T06A4.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="Q9TZH1"/>
        </source>
    </evidence>
    <sequence length="426" mass="47697" checksum="59D72B4B1A92D0EB" modified="2018-09-12" version="4">MWIDAGIHAREWIAPATAMYIAHELLLGYENDATVAKLMDHIDFYILPVMNPDGYEYSREKNRMWRKNRSPAKCARQTFSTVCCSGVDLNRNFDWFWASTGSSSDPCHDTYHGSAAFSEPESQAVRDFLEQNTPEAFISLHSYSQMWLIPYGHRKQSYPQDYHTGLRPLALRATKALYELYGTKYQVGTGADLMYEASGGSHDWAKGQLKVPYAYLIELRPKNTMMGHGFLLPEREIVPTGLETFESIKVVADELVAQFVEPVIRAKLTTTTKPAIPPYRRGYSIIDTTTMEPVDEITQKPTEAPTTEEPTTTTTEEPTTTTTTEEPTEAPTEPSPTTVEATEASTTPEASTSSETSTTENSEPNQKTSTPVAPEASTVEEETITPIKCVDYGDYCRLWGVLQLCYRDQVSKLCPKTCDSRCSFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XUN8</accession>
    <name>Q9XUN8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_T20B3.1</name>
        <name evidence="6 8" type="ORF">T20B3.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB04738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T25018">
        <property type="entry name" value="T25018"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_507245.1">
        <property type="nucleotide sequence ID" value="NM_074844.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XUN8"/>
    <dbReference type="SMR" id="Q9XUN8"/>
    <dbReference type="STRING" id="6239.T20B3.1.1"/>
    <dbReference type="PaxDb" id="6239-T20B3.1"/>
    <dbReference type="PeptideAtlas" id="Q9XUN8"/>
    <dbReference type="GeneID" id="180126"/>
    <dbReference type="UCSC" id="T20B3.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011850"/>
    <dbReference type="CTD" id="180126"/>
    <dbReference type="WormBase" id="T20B3.1a">
        <property type="protein sequence ID" value="CE20086"/>
        <property type="gene ID" value="WBGene00011850"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_5_0_1"/>
    <dbReference type="OMA" id="NQLMADC"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="PhylomeDB" id="Q9XUN8"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011850">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XUN8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000069">
        <property type="entry name" value="Protein CBG23894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF67">
        <property type="entry name" value="PEROXISOMAL CARNITINE O-OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB04738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="T20B3.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XUN8"/>
        </source>
    </evidence>
    <sequence length="608" mass="69256" checksum="07B6A6117FA46D7D" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-10-14" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XWZ2-2</accession>
    <name>ACD11_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform b of Acyl-CoA dehydrogenase family member 11</fullName>
            <ecNumber evidence="1">1.3.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acdh-11</name>
        <name evidence="3" type="ORF">Y45F3A.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2015" name="Cell" volume="161" first="1152" last="1163">
            <title>Acyl-CoA dehydrogenase drives heat adaptation by sequestering fatty acids.</title>
            <authorList>
                <person name="Ma D.K."/>
                <person name="Li Z."/>
                <person name="Lu A.Y."/>
                <person name="Sun F."/>
                <person name="Chen S."/>
                <person name="Rothe M."/>
                <person name="Menzel R."/>
                <person name="Sun F."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="25981666"/>
            <dbReference type="DOI" id="10.1016/j.cell.2015.04.026"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 19-611 IN COMPLEX WITH ACYL-COENZYME A</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-91; SER-156; GLY-158; GLY-214; GLY-443 AND ARG-455</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9XWZ2-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_057934"/>
        </isoform>
        <isoform>
            <id>Q9XWZ2-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001379451.1">
        <property type="nucleotide sequence ID" value="NM_001392194.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y45F3A.3b">
        <property type="protein sequence ID" value="CE39116"/>
        <property type="gene ID" value="WBGene00012860"/>
        <property type="gene designation" value="acdh-11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y45F3A.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y45F3A.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="5">
        <source>
            <dbReference type="PDB" id="4Y9J"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="6">
        <source>
            <dbReference type="PDB" id="4Y9L"/>
        </source>
    </evidence>
    <sequence length="608" mass="67257" checksum="E25DD7B8352D5457" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLQ2</accession>
    <name>V6CLQ2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">hsp-16.2</name>
        <name evidence="6" type="ORF">CELE_Y46H3A.3</name>
        <name evidence="8" type="ORF">Y46H3A.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDK13498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294665.1">
        <property type="nucleotide sequence ID" value="NM_001307736.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLQ2"/>
    <dbReference type="SMR" id="V6CLQ2"/>
    <dbReference type="PeptideAtlas" id="V6CLQ2"/>
    <dbReference type="GeneID" id="178659"/>
    <dbReference type="KEGG" id="cel:CELE_Y46H3A.3"/>
    <dbReference type="AGR" id="WB:WBGene00002016"/>
    <dbReference type="CTD" id="178659"/>
    <dbReference type="WormBase" id="Y46H3A.3b">
        <property type="protein sequence ID" value="CE49428"/>
        <property type="gene ID" value="WBGene00002016"/>
        <property type="gene designation" value="hsp-16.2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095001_7_0_1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002016">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLQ2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein Hsp-16.2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
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        <property type="entry name" value="Alpha-crystallin/HSP_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF1">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-16.1_HSP-16.11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036514">
        <property type="entry name" value="Sm_HSP_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDK13498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y46H3A.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLQ2"/>
        </source>
    </evidence>
    <sequence length="127" mass="14073" checksum="09E497175E4CC6EF" modified="2014-02-19" version="1">MRDMALMERQFAPVCRISPSESSEIVNNDQKFAINLNVSQFKPEDLKINLDGRTLSIQGEQELKTDHGYSKKSFSRVILLPEDVDVGAVASNLSEDGKLSIEAPKKEAVQGRSIPIQQAIVEEKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLQ3</accession>
    <name>V6CLQ3_CAEEL</name>
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        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">znf-236</name>
        <name evidence="9" type="ORF">CELE_Y48G8AL.10</name>
        <name evidence="11" type="ORF">Y48G8AL.10</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13487.1"/>
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    </dbReference>
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    <dbReference type="AlphaFoldDB" id="V6CLQ3"/>
    <dbReference type="GeneID" id="3565634"/>
    <dbReference type="AGR" id="WB:WBGene00021689"/>
    <dbReference type="CTD" id="3565634"/>
    <dbReference type="WormBase" id="Y48G8AL.10b">
        <property type="protein sequence ID" value="CE49378"/>
        <property type="gene ID" value="WBGene00021689"/>
        <property type="gene designation" value="znf-236"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021689">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLQ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003272">
        <property type="entry name" value="gastrula zinc finger protein XlCGF67.1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002539">
        <property type="entry name" value="GD10244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF216">
        <property type="entry name" value="ZINC FINGER PROTEIN 420-LIKE"/>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="841"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDK13487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y48G8AL.10b"/>
        </source>
    </evidence>
    <sequence length="882" mass="101467" checksum="7314BEA400E0CC74" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLQ8</accession>
    <name>V6CLQ8_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Zasp-like motif domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">pqn-22</name>
        <name evidence="5" type="ORF">C46G7.4</name>
        <name evidence="3" type="ORF">CELE_C46G7.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293804.1">
        <property type="nucleotide sequence ID" value="NM_001306875.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLQ8"/>
    <dbReference type="PeptideAtlas" id="V6CLQ8"/>
    <dbReference type="GeneID" id="177369"/>
    <dbReference type="AGR" id="WB:WBGene00004112"/>
    <dbReference type="CTD" id="177369"/>
    <dbReference type="WormBase" id="C46G7.4o">
        <property type="protein sequence ID" value="CE49193"/>
        <property type="gene ID" value="WBGene00004112"/>
        <property type="gene designation" value="pqn-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919374at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004112">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLQ8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zasp-like motif" evidence="2">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="912"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C46G7.4o"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLQ8"/>
        </source>
    </evidence>
    <sequence length="1146" mass="129087" checksum="A25A2987CA4916C3" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLS0</accession>
    <name>V6CLS0_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">rnp-8</name>
        <name evidence="1" type="ORF">CELE_R119.7</name>
        <name evidence="3" type="ORF">R119.7</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380158.1">
        <property type="nucleotide sequence ID" value="NM_001393194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLS0"/>
    <dbReference type="PeptideAtlas" id="V6CLS0"/>
    <dbReference type="GeneID" id="171627"/>
    <dbReference type="KEGG" id="cel:CELE_R119.7"/>
    <dbReference type="AGR" id="WB:WBGene00020091"/>
    <dbReference type="CTD" id="171627"/>
    <dbReference type="WormBase" id="R119.7b">
        <property type="protein sequence ID" value="CE49206"/>
        <property type="gene ID" value="WBGene00020091"/>
        <property type="gene designation" value="rnp-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_419924_0_0_1"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020091">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLS0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="R119.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLS0"/>
        </source>
    </evidence>
    <sequence length="184" mass="20047" checksum="2F2164F308BE1733" modified="2014-02-19" version="1">MIVSTGNLRINPTNIDHHDEPAPWSPLKRLRAESGSLSTAQVASPEFSPIKPKTMEFHETEDDVFETGPPPTYLSEGNENAEKKCVEQPKINYDDINNSRLPSNSHSAAPNSEKKHFVFPEYPMCRHSSVPSIAHLVGDLSDFCPHATADEKMLLDEASSIIENTTPAVSTAPAAAPGATMLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLS1</accession>
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        <submittedName>
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        <name evidence="2 4" type="primary">blos-2</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13507.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="NP_001368404.1">
        <property type="nucleotide sequence ID" value="NM_001380271.1"/>
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    <dbReference type="AlphaFoldDB" id="V6CLS1"/>
    <dbReference type="SMR" id="V6CLS1"/>
    <dbReference type="PeptideAtlas" id="V6CLS1"/>
    <dbReference type="GeneID" id="177395"/>
    <dbReference type="AGR" id="WB:WBGene00022251"/>
    <dbReference type="CTD" id="177395"/>
    <dbReference type="WormBase" id="Y73B6BL.30b">
        <property type="protein sequence ID" value="CE49291"/>
        <property type="gene ID" value="WBGene00022251"/>
        <property type="gene designation" value="blos-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110820_2_0_1"/>
    <dbReference type="OrthoDB" id="244061at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022251">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLS1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y73B6BL.30b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLS1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8780" checksum="BD29ECB806AF8F24" modified="2014-02-19" version="1">MNNTTAQRYVDMKVVAEKVAGKLDNLNQKYENLRPYLSQIDAMDESTRRLEEATAVLENYVTQLESKLTNIQQQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLS2</accession>
    <name>V6CLS2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">fkh-7</name>
        <name evidence="13" type="ORF">CELE_F26D12.1</name>
        <name evidence="15" type="ORF">F26D12.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293813.1">
        <property type="nucleotide sequence ID" value="NM_001306884.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLS2"/>
    <dbReference type="SMR" id="V6CLS2"/>
    <dbReference type="GeneID" id="177340"/>
    <dbReference type="AGR" id="WB:WBGene00001439"/>
    <dbReference type="CTD" id="177340"/>
    <dbReference type="WormBase" id="F26D12.1j">
        <property type="protein sequence ID" value="CE49149"/>
        <property type="gene ID" value="WBGene00001439"/>
        <property type="gene designation" value="fkh-7"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830876at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001439">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLS2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20065">
        <property type="entry name" value="FH_FOXP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047412">
        <property type="entry name" value="FH_FOXP1_P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032354">
        <property type="entry name" value="FOXP-CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16159">
        <property type="entry name" value="FOXP-CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="563"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="563"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="489"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
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        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDK13559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F26D12.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLS2"/>
        </source>
    </evidence>
    <sequence length="764" mass="83574" checksum="838FB20AA4BABE5E" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLS4</accession>
    <name>V6CLS4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc Finger and Homeobox</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">zfh-2</name>
        <name evidence="15" type="ORF">CELE_ZC123.3</name>
        <name evidence="17" type="ORF">ZC123.3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368416.1">
        <property type="nucleotide sequence ID" value="NM_001380629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLS4"/>
    <dbReference type="SMR" id="V6CLS4"/>
    <dbReference type="PeptideAtlas" id="V6CLS4"/>
    <dbReference type="GeneID" id="171670"/>
    <dbReference type="AGR" id="WB:WBGene00022518"/>
    <dbReference type="CTD" id="171670"/>
    <dbReference type="WormBase" id="ZC123.3e">
        <property type="protein sequence ID" value="CE49442"/>
        <property type="gene ID" value="WBGene00022518"/>
        <property type="gene designation" value="zfh-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003443_1_0_1"/>
    <dbReference type="OrthoDB" id="6417226at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022518">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLS4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000527">
        <property type="entry name" value="Zinc Finger and Homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000080">
        <property type="entry name" value="Zinc finger homeobox protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000064">
        <property type="entry name" value="Zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051968">
        <property type="entry name" value="ZnFinger_Homeobox_TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="261"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="437"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="518"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="744"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="817"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="263"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="439"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="746"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="354"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDK13523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="ZC123.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLS4"/>
        </source>
    </evidence>
    <sequence length="1023" mass="113947" checksum="76B1BD677D3FD6C8" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLS7</accession>
    <name>V6CLS7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UNC-44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">unc-44</name>
        <name evidence="13" type="ORF">B0350.2</name>
        <name evidence="11" type="ORF">CELE_B0350.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368408.1">
        <property type="nucleotide sequence ID" value="NM_001380253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLS7"/>
    <dbReference type="SMR" id="V6CLS7"/>
    <dbReference type="PeptideAtlas" id="V6CLS7"/>
    <dbReference type="GeneID" id="177366"/>
    <dbReference type="AGR" id="WB:WBGene00006780"/>
    <dbReference type="CTD" id="177366"/>
    <dbReference type="WormBase" id="B0350.2i">
        <property type="protein sequence ID" value="CE49185"/>
        <property type="gene ID" value="WBGene00006780"/>
        <property type="gene designation" value="unc-44"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006780">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLS7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08317">
        <property type="entry name" value="Death_ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000001">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000002">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040745">
        <property type="entry name" value="Ankyrin_UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17809">
        <property type="entry name" value="UPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    <sequence length="1034" mass="114788" checksum="D9D6BB2E985114E6" modified="2014-02-19" version="1"> </sequence>
</entry>
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    <accession>V6CLT1</accession>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="C31H1.8d"/>
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    </evidence>
    <sequence length="429" mass="48833" checksum="D42BCD8E9B8B2D7F" modified="2014-02-19" version="1">MRRLSSGDLNVIRRMTEEIDFDLKNIIYDGNEITGETDADNGNDRACFKPGPDYPIDQQMLFLKQCIKKIDTRPPNMYYLTNGWSVDNFEALFKYMIRSGEDCSRDTLLRVEFRDCVVSLKSLYDFIEEYATFKGVKMHSDYVYAIVHSRNEKLERRLRGAIDSFMEIESKIRQARISYVSSFTINSPHTPNVSIIVKFCCLKPCNSDAKTKMRQISVQVDHVTGRSRMSLPDVRQHEGLVCECLGDFSLIRHRPTSVPVTKILDEHPPLIVDEEVRLKSSYQFNPVTGEPIPDDEQQQEQTEIEASIEDPLEINDFVEMFPLILVLLEKAGIQELEDGDAPEKSVSKYPKKRSIVDGASSETCEDTQSVGSSESSEPRSPEFTEYSESEDTAADSETSDSESSSEDEKENMKSSIKELELIKDAPEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLT5</accession>
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        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="WBGene00022518"/>
        <property type="gene designation" value="zfh-2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7 12 13" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="858"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="931"/>
            <end position="955"/>
        </location>
    </feature>
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        <location>
            <begin position="377"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="553"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="860"/>
            <end position="919"/>
        </location>
    </feature>
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            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="468"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDK13522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="ZC123.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLT5"/>
        </source>
    </evidence>
    <sequence length="1137" mass="127058" checksum="1CDD566051DEC723" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLT6</accession>
    <name>V6CLT6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">unc-77</name>
        <name evidence="27" type="ORF">C11D2.6</name>
        <name evidence="25" type="ORF">CELE_C11D2.6</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293822.1">
        <property type="nucleotide sequence ID" value="NM_001306893.3"/>
    </dbReference>
    <dbReference type="SMR" id="V6CLT6"/>
    <dbReference type="GeneID" id="177379"/>
    <dbReference type="AGR" id="WB:WBGene00006809"/>
    <dbReference type="CTD" id="177379"/>
    <dbReference type="WormBase" id="C11D2.6k">
        <property type="protein sequence ID" value="CE49459"/>
        <property type="gene ID" value="WBGene00006809"/>
        <property type="gene designation" value="unc-77"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006809">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLT6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000089">
        <property type="entry name" value="Four domain-type voltage-gated ion channel alpha-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000080">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000060">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000061">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000066">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000030">
        <property type="entry name" value="sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000032">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000034">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF2">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="878"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="923"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="958"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1020"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1134"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1215"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1247"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1287"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1321"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1359"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1444"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="69"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="417"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="884"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="1213"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1647"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1656"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="1672"/>
            <end position="1682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDK13574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="C11D2.6k"/>
        </source>
    </evidence>
    <sequence length="1815" mass="209683" checksum="B77EB96107FB9C4C" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLT8</accession>
    <name>V6CLT8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pqn-22</name>
        <name evidence="4" type="ORF">C46G7.4</name>
        <name evidence="2" type="ORF">CELE_C46G7.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368418.1">
        <property type="nucleotide sequence ID" value="NM_001380257.1"/>
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</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLU1</accession>
    <name>V6CLU1_CAEEL</name>
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        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
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        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
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        <name evidence="25 27" type="primary">unc-77</name>
        <name evidence="27" type="ORF">C11D2.6</name>
        <name evidence="25" type="ORF">CELE_C11D2.6</name>
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    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
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        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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    </comment>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="6" id="KW-0677">Repeat</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="C11D2.6p"/>
        </source>
    </evidence>
    <sequence length="1838" mass="212194" checksum="779E1FB43537C43F" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLU3</accession>
    <name>V6CLU3_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Zasp-like motif domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3 5" type="primary">pqn-22</name>
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        <name evidence="3" type="ORF">CELE_C46G7.4</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293798.1">
        <property type="nucleotide sequence ID" value="NM_001306869.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLU3"/>
    <dbReference type="PeptideAtlas" id="V6CLU3"/>
    <dbReference type="GeneID" id="177369"/>
    <dbReference type="AGR" id="WB:WBGene00004112"/>
    <dbReference type="CTD" id="177369"/>
    <dbReference type="WormBase" id="C46G7.4i">
        <property type="protein sequence ID" value="CE49324"/>
        <property type="gene ID" value="WBGene00004112"/>
        <property type="gene designation" value="pqn-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919374at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004112">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLU3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="3"/>
            <end position="28"/>
        </location>
    </feature>
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            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="670"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        <source>
            <dbReference type="SMART" id="SM00735"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDK13538.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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            <dbReference type="WormBase" id="C46G7.4i"/>
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    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLU3"/>
        </source>
    </evidence>
    <sequence length="992" mass="111746" checksum="478AF1312875623D" modified="2014-02-19" version="1"> </sequence>
</entry>
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    <accession>V6CLU7</accession>
    <name>V6CLU7_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y34D9A.3</name>
        <name evidence="1 3" type="ORF">Y34D9A.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293255.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLU7"/>
    <dbReference type="PeptideAtlas" id="V6CLU7"/>
    <dbReference type="GeneID" id="171684"/>
    <dbReference type="AGR" id="WB:WBGene00021329"/>
    <dbReference type="CTD" id="171684"/>
    <dbReference type="WormBase" id="Y34D9A.3d">
        <property type="protein sequence ID" value="CE49431"/>
        <property type="gene ID" value="WBGene00021329"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019952_0_0_1"/>
    <dbReference type="OrthoDB" id="5817237at2759"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021329">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLU7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052452">
        <property type="entry name" value="Ankyrin-MYND_dom_contain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24150">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24150:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y34D9A.3d"/>
        </source>
    </evidence>
    <sequence length="175" mass="20274" checksum="1F37E6A850B7EF41" modified="2014-02-19" version="1">MEIIEEICEKIRIKSNFRHLPDISFLKPNPDTIITQISEIFDTKIAKNDERIVEICSILLEKLAPQLQAFGDRGKTPFCQIVNIIVDKYVKNSVEPVNFQLFREVCERAVDGFAMMTEQWNFLFLSAKILTILNLTRREAGLFAVLMRKINKNEILLTKLRGKKEFVQLEGSLEL</sequence>
</entry>
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    <accession>V6CLU8</accession>
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        <submittedName>
            <fullName evidence="3">Zasp-like motif domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">pqn-22</name>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001293803.1">
        <property type="nucleotide sequence ID" value="NM_001306874.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLU8"/>
    <dbReference type="PeptideAtlas" id="V6CLU8"/>
    <dbReference type="GeneID" id="177369"/>
    <dbReference type="AGR" id="WB:WBGene00004112"/>
    <dbReference type="CTD" id="177369"/>
    <dbReference type="WormBase" id="C46G7.4n">
        <property type="protein sequence ID" value="CE49278"/>
        <property type="gene ID" value="WBGene00004112"/>
        <property type="gene designation" value="pqn-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919374at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004112">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLU8">
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    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zasp-like motif" evidence="2">
        <location>
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            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDK13543.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1010" mass="113313" checksum="FC5629C5A4FFE9EC" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLV0</accession>
    <name>V6CLV0_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Zasp-like motif domain-containing protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="377"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="377"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDK13558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F26D12.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLW4"/>
        </source>
    </evidence>
    <sequence length="573" mass="62269" checksum="D3EE368B8FCA88DE" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLW5</accession>
    <name>V6CLW5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Sodium/potassium-transporting ATPase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">nkb-3</name>
        <name evidence="19" type="ORF">CELE_F55F3.3</name>
        <name evidence="21" type="ORF">F55F3.3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="17">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDK13601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294779.1">
        <property type="nucleotide sequence ID" value="NM_001307850.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLW5"/>
    <dbReference type="SMR" id="V6CLW5"/>
    <dbReference type="PeptideAtlas" id="V6CLW5"/>
    <dbReference type="GeneID" id="181494"/>
    <dbReference type="AGR" id="WB:WBGene00010117"/>
    <dbReference type="CTD" id="181494"/>
    <dbReference type="WormBase" id="F55F3.3b">
        <property type="protein sequence ID" value="CE49141"/>
        <property type="gene ID" value="WBGene00010117"/>
        <property type="gene designation" value="nkb-3"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010117">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLW5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Probable sodium/potassium-transporting ATPase subunit beta-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00390">
        <property type="entry name" value="ATPASE_NA_K_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDK13601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WormBase" id="F55F3.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLW5"/>
        </source>
    </evidence>
    <sequence length="303" mass="34234" checksum="DD01FE988C5580A6" modified="2014-02-19" version="1">MNGEAKAEPETFAQFLYNKDKGTVLGRTGTSWCQITVFYIIFYIFLSAFFIGCLSIFLRTLDPKVPRFYGKGTIIGVNPGVGYQPWLKENPDSTLIKFNLQDSKSWEPYVKQLDNYLSKYKNTNETRDCGASDNNDALETDTDTFPCRFDLGLFEKANCGAKDQYGYKSGKPCVAVSLNRLIGWRPVNYDDGSVPEEIKGRYKPGSITINCEGATSFDKEHLGKVKYIPETGIDGRYYPYVFVPSYQQPIAMVKFDTIPRNKLVIVECRAYASNIEHDISTRLGMVYFELFVEDKKPVAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLW7</accession>
    <name>V6CLW7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dystrophin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">dys-1</name>
        <name evidence="17" type="ORF">CELE_F15D3.1</name>
        <name evidence="19" type="ORF">F15D3.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293241.1">
        <property type="nucleotide sequence ID" value="NM_001306312.3"/>
    </dbReference>
    <dbReference type="SMR" id="V6CLW7"/>
    <dbReference type="PeptideAtlas" id="V6CLW7"/>
    <dbReference type="GeneID" id="173038"/>
    <dbReference type="AGR" id="WB:WBGene00001131"/>
    <dbReference type="CTD" id="173038"/>
    <dbReference type="WormBase" id="F15D3.1e">
        <property type="protein sequence ID" value="CE49456"/>
        <property type="gene ID" value="WBGene00001131"/>
        <property type="gene designation" value="dys-1"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001131">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:cytoskeleton"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:sarcolemma"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:modulation of chemical synaptic transmission"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:muscle cell cellular homeostasis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="EFh_DMD_like"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF-hand_dom_typ1"/>
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        <property type="entry name" value="EF-hand_dom_typ2"/>
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    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
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        <property type="entry name" value="Spectrin/alpha-actinin"/>
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    <dbReference type="InterPro" id="IPR056503">
        <property type="entry name" value="Spectrin_Dys-1"/>
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    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
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    <dbReference type="InterPro" id="IPR001202">
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="Znf_ZZ"/>
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        <property type="entry name" value="Znf_ZZ_sf"/>
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        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WW" evidence="15">
        <location>
            <begin position="950"/>
            <end position="984"/>
        </location>
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        <location>
            <begin position="1204"/>
            <end position="1260"/>
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        <location>
            <begin position="290"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1384"/>
            <end position="1425"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1471"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
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    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="503"/>
            <end position="533"/>
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        <location>
            <begin position="787"/>
            <end position="851"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="294"/>
            <end position="314"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1471"/>
            <end position="1482"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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            <dbReference type="ARBA" id="ARBA00004278"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50020"/>
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        <source>
            <dbReference type="PROSITE" id="PS50135"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDK13552.1"/>
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    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="F15D3.1e"/>
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    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLW7"/>
        </source>
    </evidence>
    <sequence length="1577" mass="178663" checksum="95D871624C4FC953" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLX0</accession>
    <name>V6CLX0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_Y65B4A.2</name>
        <name evidence="5 7" type="ORF">Y65B4A.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293245.1">
        <property type="nucleotide sequence ID" value="NM_001306316.1"/>
    </dbReference>
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    <dbReference type="PaxDb" id="6239-Y65B4A.2.2"/>
    <dbReference type="GeneID" id="171655"/>
    <dbReference type="KEGG" id="cel:CELE_Y65B4A.2"/>
    <dbReference type="AGR" id="WB:WBGene00022026"/>
    <dbReference type="CTD" id="171655"/>
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        <property type="protein sequence ID" value="CE49131"/>
        <property type="gene ID" value="WBGene00022026"/>
    </dbReference>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022026">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="152"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDK13563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y65B4A.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLX0"/>
        </source>
    </evidence>
    <sequence length="435" mass="49929" checksum="1BD312C0102D534C" modified="2014-02-19" version="1">MRRRVALDNDEHDEMYPTDKEQTRTTFETRSRRKRLAQVAATIASVILLLLAVLGLVYGSFYLYRRYVTDANDKRDNDEYLRKLVRQVNDSPETTWKAKFNKFGVKNRSYGFKYTRNQTAVEEYVEQIRKFFESDAMKRHLDELENFNSSDVPKNFDARQKWPNCPSISNVPNQGGCGSCFAVAAAGVASDRACIHSNGTFKSLLSEEDIIGCCSVCGNCYGGDPLKALTYWVNQGLVTGGRDGCRPYSFDLSCGVPCSPATFFEAEEKRTCMKRCQNIYYQQKYEEDKHFATFAYSMYPRSMTVSPDGKERVKVPTIIGHFNDKKTEKLNVTEYRDIIKKEILLYGPTTMAFPVPEEFLHYSSGVFRPYPTDGFDDRIVYWHVVRLIGWGESDDGTHYWLAVNSFGNHWGDNGLFKINTDDMEKYGLEYETAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLX2</accession>
    <name>V6CLX2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">fkh-7</name>
        <name evidence="13" type="ORF">CELE_F26D12.1</name>
        <name evidence="15" type="ORF">F26D12.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293811.1">
        <property type="nucleotide sequence ID" value="NM_001306882.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLX2"/>
    <dbReference type="SMR" id="V6CLX2"/>
    <dbReference type="GeneID" id="177340"/>
    <dbReference type="AGR" id="WB:WBGene00001439"/>
    <dbReference type="CTD" id="177340"/>
    <dbReference type="WormBase" id="F26D12.1g">
        <property type="protein sequence ID" value="CE49226"/>
        <property type="gene ID" value="WBGene00001439"/>
        <property type="gene designation" value="fkh-7"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830876at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001439">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLX2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20065">
        <property type="entry name" value="FH_FOXP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047412">
        <property type="entry name" value="FH_FOXP1_P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032354">
        <property type="entry name" value="FOXP-CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16159">
        <property type="entry name" value="FOXP-CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="563"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="563"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="489"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="644"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDK13557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F26D12.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLX2"/>
        </source>
    </evidence>
    <sequence length="759" mass="82821" checksum="1733408B49D53F14" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLX5</accession>
    <name>V6CLX5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipocln_cytosolic_FA-bd_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">lpr-1</name>
        <name evidence="2" type="ORF">CELE_Y65B4BR.2</name>
        <name evidence="4" type="ORF">Y65B4BR.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293266.1">
        <property type="nucleotide sequence ID" value="NM_001306337.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLX5"/>
    <dbReference type="SMR" id="V6CLX5"/>
    <dbReference type="GeneID" id="171648"/>
    <dbReference type="KEGG" id="cel:CELE_Y65B4BR.2"/>
    <dbReference type="AGR" id="WB:WBGene00002393"/>
    <dbReference type="CTD" id="171648"/>
    <dbReference type="WormBase" id="Y65B4BR.2b">
        <property type="protein sequence ID" value="CE49349"/>
        <property type="gene ID" value="WBGene00002393"/>
        <property type="gene designation" value="lpr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104321_0_0_1"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002393">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLX5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000019">
        <property type="entry name" value="LiPocalin-Related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056868">
        <property type="entry name" value="Lipocalin_dom_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437:SF2">
        <property type="entry name" value="LIPOCLN_CYTOSOLIC_FA-BD_DOM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24976">
        <property type="entry name" value="Lipocalin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin" evidence="1">
        <location>
            <begin position="42"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.2b"/>
        </source>
    </evidence>
    <sequence length="218" mass="25030" checksum="10C484B5DF460FA2" modified="2014-02-19" version="1">MRLFENYAASCRPKSKKDFNVDQLANLLQSLQMDEVATKAYNSLFFSMADMQIEKFMGKWYTVVDSKEVHKEDCSIFYFDMVLQTPYTATFTSKQYGVINNDVVTNEGYGSMVGPEPGAVLITTGSERDQCPFFPVRIGGLSDEGEYQYMILSTPLKYPTMVLTRDLTLFETKWKREVYDFVEKNGFMSPMAALNTRLHFTDVDVCRKVNKLYENGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLX6</accession>
    <name>V6CLX6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y65B4A.9</name>
        <name evidence="3 5" type="ORF">Y65B4A.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13568.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLX6"/>
    <dbReference type="SMR" id="V6CLX6"/>
    <dbReference type="PeptideAtlas" id="V6CLX6"/>
    <dbReference type="AGR" id="WB:WBGene00022032"/>
    <dbReference type="WormBase" id="Y65B4A.9b">
        <property type="protein sequence ID" value="CE54236"/>
        <property type="gene ID" value="WBGene00022032"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1476436_0_0_1"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022032">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLX6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13568.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y65B4A.9b"/>
        </source>
    </evidence>
    <sequence length="369" mass="42138" checksum="5ECAABB323B8E2DC" modified="2021-06-02" version="2">MTSVGPGQPQKELIRAQNGTYEVTKPLATGTFGSIYKLLRQMSVVLASIHHPSPFFTNIEERGTVPNRFLFIVMPLYGENLYELMMNTNKDRKFSMATGLHLAEQTLAAIRDLHRNGFIHRDIKPSHFCIGREIDGQHHQVYLLDFGLCKRPRFVKKNDEAEEQMRKNAIHYRGVVKYASVHAHQGKNLGYKDDMESWWYMVLEFFLGALPWALLNKESEQDVLHLKRRITAPMVASVWRTTPETTAGFFDLLTIIREPKDVAEFVEYDRIADGIQKLFEKSKSNTQEPPDWDCMTDYKGPGYQQVLMIAPPEVGLKPEMDFGKSDPGAGGESGEQPKKEDVDKKKKKKKKSKKKGKSNNKTTSAEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLX8</accession>
    <name>V6CLX8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">fkh-7</name>
        <name evidence="13" type="ORF">CELE_F26D12.1</name>
        <name evidence="15" type="ORF">F26D12.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293816.1">
        <property type="nucleotide sequence ID" value="NM_001306887.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLX8"/>
    <dbReference type="SMR" id="V6CLX8"/>
    <dbReference type="GeneID" id="177340"/>
    <dbReference type="AGR" id="WB:WBGene00001439"/>
    <dbReference type="CTD" id="177340"/>
    <dbReference type="WormBase" id="F26D12.1m">
        <property type="protein sequence ID" value="CE49364"/>
        <property type="gene ID" value="WBGene00001439"/>
        <property type="gene designation" value="fkh-7"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830876at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001439">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLX8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20065">
        <property type="entry name" value="FH_FOXP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047412">
        <property type="entry name" value="FH_FOXP1_P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032354">
        <property type="entry name" value="FOXP-CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16159">
        <property type="entry name" value="FOXP-CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="377"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="377"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDK13562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F26D12.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLX8"/>
        </source>
    </evidence>
    <sequence length="559" mass="60866" checksum="D94D5132E6FA9B5B" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLZ6</accession>
    <name>V6CLZ6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y34D9A.3</name>
        <name evidence="1 3" type="ORF">Y34D9A.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLZ6"/>
    <dbReference type="AGR" id="WB:WBGene00021329"/>
    <dbReference type="WormBase" id="Y34D9A.3b">
        <property type="protein sequence ID" value="CE49232"/>
        <property type="gene ID" value="WBGene00021329"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019952_0_0_1"/>
    <dbReference type="OrthoDB" id="5817237at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021329">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLZ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052452">
        <property type="entry name" value="Ankyrin-MYND_dom_contain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24150">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24150:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y34D9A.3b"/>
        </source>
    </evidence>
    <sequence length="710" mass="82110" checksum="6EA8418FAA21CF7A" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLZ7</accession>
    <name>V6CLZ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y34D9A.7</name>
        <name evidence="1 3" type="ORF">Y34D9A.7</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293259.1">
        <property type="nucleotide sequence ID" value="NM_001306330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLZ7"/>
    <dbReference type="SMR" id="V6CLZ7"/>
    <dbReference type="GeneID" id="189588"/>
    <dbReference type="AGR" id="WB:WBGene00021332"/>
    <dbReference type="CTD" id="189588"/>
    <dbReference type="WormBase" id="Y34D9A.7c">
        <property type="protein sequence ID" value="CE49270"/>
        <property type="gene ID" value="WBGene00021332"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054833_0_0_1"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021332">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLZ7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y34D9A.7c"/>
        </source>
    </evidence>
    <sequence length="77" mass="8581" checksum="FD3E83C1444C55A3" modified="2014-02-19" version="1">MGESISEFIGTPIFSRRDVTGTWIEDTVPSLEAFSVGIVPFEAKEEEKPRGIFKKIMSTLKGITGRNSGDDEMKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>W6EKY2</accession>
    <name>W6EKY2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">14-3-3 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">14-3-3 zeta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftt-2</name>
        <name evidence="6" type="ORF">CELE_F52D10.3</name>
        <name evidence="8" type="ORF">F52D10.3</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Convergent Origin and Evolution of Mutually Exclusive Splicing at 14-3-3 zeta Locus in Nematoda and Arthropod.</title>
            <authorList>
                <person name="Zhan L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KF893312">
        <property type="protein sequence ID" value="AHJ11148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="SKC30523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001337315.1">
        <property type="nucleotide sequence ID" value="NM_001350351.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6EKY2"/>
    <dbReference type="SMR" id="W6EKY2"/>
    <dbReference type="PeptideAtlas" id="W6EKY2"/>
    <dbReference type="GeneID" id="181348"/>
    <dbReference type="AGR" id="WB:WBGene00001502"/>
    <dbReference type="CTD" id="181348"/>
    <dbReference type="WormBase" id="F52D10.3c">
        <property type="protein sequence ID" value="CE51934"/>
        <property type="gene ID" value="WBGene00001502"/>
        <property type="gene designation" value="ftt-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058290_1_0_1"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001502">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 21 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6EKY2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AHJ11148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SKC30523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F52D10.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="W6EKY2"/>
        </source>
    </evidence>
    <sequence length="248" mass="27732" checksum="2C5E23393DAF7965" modified="2014-04-16" version="1">MSDGKEELVNRAKLAEQAERYDDMAASMKKVTELGAELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEGSEKKQQMAKEYREKVEKELRDICQDVLNLLDKFLIPKAGAAESKVFYLKMKGDYYRYLAEVASGDDRNSVANIGQTAYAEALEIANKDLSPTNCVRLGLALNYSVFFYEVAASPDRACQLSKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDAATDDTDANETEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBJ8</accession>
    <name>A0A131MBJ8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="3">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">daf-4</name>
        <name evidence="22" type="ORF">C05D2.1</name>
        <name evidence="20" type="ORF">CELE_C05D2.1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18673"/>
            <dbReference type="Rhea" id="RHEA-COMP:11022"/>
            <dbReference type="Rhea" id="RHEA-COMP:11023"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="3"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CZR14507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317770.1">
        <property type="nucleotide sequence ID" value="NM_001330884.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBJ8"/>
    <dbReference type="SMR" id="A0A131MBJ8"/>
    <dbReference type="GeneID" id="175781"/>
    <dbReference type="AGR" id="WB:WBGene00000900"/>
    <dbReference type="CTD" id="175781"/>
    <dbReference type="WormBase" id="C05D2.1b">
        <property type="protein sequence ID" value="CE51404"/>
        <property type="gene ID" value="WBGene00000900"/>
        <property type="gene designation" value="daf-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="547665at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000900">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBJ8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000487">
        <property type="entry name" value="Anti-Muellerian hormone type-2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000958">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF100">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="87"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="386"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CZR14507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="C05D2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBJ8"/>
        </source>
    </evidence>
    <sequence length="525" mass="60294" checksum="20ACC0145DD3F4D7" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBK4</accession>
    <name>A0A131MBK4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle collagen 99</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">col-99</name>
        <name evidence="4" type="ORF">CELE_F29C4.8</name>
        <name evidence="6" type="ORF">F29C4.8</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001322764.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBK4"/>
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    <dbReference type="GeneID" id="185112"/>
    <dbReference type="AGR" id="WB:WBGene00000674"/>
    <dbReference type="CTD" id="185112"/>
    <dbReference type="WormBase" id="F29C4.8q">
        <property type="protein sequence ID" value="CE51319"/>
        <property type="gene ID" value="WBGene00000674"/>
        <property type="gene designation" value="col-99"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8964326at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000674">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBK4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF423">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
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        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CZR14533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F29C4.8q"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBK4"/>
        </source>
    </evidence>
    <sequence length="684" mass="69013" checksum="7DE15EAD10CB9A5F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309620.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBL4"/>
    <dbReference type="GeneID" id="192037"/>
    <dbReference type="KEGG" id="cel:CELE_C07G3.3"/>
    <dbReference type="AGR" id="WB:WBGene00006258"/>
    <dbReference type="CTD" id="192037"/>
    <dbReference type="WormBase" id="C07G3.3b">
        <property type="protein sequence ID" value="CE51335"/>
        <property type="gene ID" value="WBGene00006258"/>
        <property type="gene designation" value="str-227"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5784785at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF254">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C07G3.3b"/>
        </source>
    </evidence>
    <sequence length="246" mass="27766" checksum="FA2985C9C9EDC07F" modified="2016-05-11" version="1">MAVFAVHFVYRWLVVTEHPLLETFNGWKIWIWFSVPMWYGLTWICTGYILSAPNEHTSRFIKDNVKEIFDLEFDEYVYLGPFLYEKTDNGTIDVHIVPFIGLGIISGTIVSSIIIVLVFGILCYQKINKLVATTAASAKLIKLQRQLFYALVIQTLVPFILMHIPAAIMFAFVFLDIDLGVYSAVVSMTIAIYPAVDPIPTLVIVENYRKTIIRYLKLDCVKRSSVAVATSTTEARSAKASDPVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBL5</accession>
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        <submittedName>
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        <name evidence="2 4" type="primary">sdz-18</name>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="CTD" id="185773"/>
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        <property type="protein sequence ID" value="CE51433"/>
        <property type="gene ID" value="WBGene00018442"/>
        <property type="gene designation" value="sdz-18"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437903at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018442">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBL5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052664">
        <property type="entry name" value="BTB-MATH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F45C12.11b"/>
        </source>
    </evidence>
    <sequence length="238" mass="27481" checksum="1D794956DC0EEC60" modified="2016-05-11" version="1">MRIKRDNGFMSFGLYCPMTGKTTNWSIVADIRVELMPLTGMWKSVECECKIAKSPSLISEVLRSTIMPWGRMMTNYVVDDALMIEVFVTIKSMTGFERPYNLRSFDESMEEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSAINDLTVEGILHIADMYDTPMVVRKCEEFLIKGTKLPAKKKLQMAFRYKMENFMRNYYAELGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBL6</accession>
    <name>A0A131MBL6_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">Cuticle collagen 99</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">col-99</name>
        <name evidence="4" type="ORF">CELE_F29C4.8</name>
        <name evidence="6" type="ORF">F29C4.8</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
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            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
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    <dbReference type="CTD" id="185112"/>
    <dbReference type="WormBase" id="F29C4.8k">
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        <property type="gene ID" value="WBGene00000674"/>
        <property type="gene designation" value="col-99"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8964326at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000674">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBL6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF423">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Collagen"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="170"/>
            <end position="451"/>
        </location>
    </feature>
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        <location>
            <begin position="482"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="723"/>
        </location>
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        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
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        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CZR14527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="F29C4.8k"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBL6"/>
        </source>
    </evidence>
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</entry>
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        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBM3"/>
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    <dbReference type="GeneID" id="173502"/>
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    <dbReference type="CTD" id="173502"/>
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        <property type="gene ID" value="WBGene00018734"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018734">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBM3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
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    </dbReference>
    <dbReference type="GO" id="GO:0051056">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000002">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF32">
        <property type="entry name" value="RAP GTPASE ACTIVATING PROTEIN 1, ISOFORM H"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="149"/>
            <end position="365"/>
        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="528"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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            <end position="456"/>
        </location>
    </feature>
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            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CZR14481.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0007829" key="10">
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            <dbReference type="PeptideAtlas" id="A0A131MBM3"/>
        </source>
    </evidence>
    <sequence length="608" mass="68099" checksum="4937AF1CD56AA4EF" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBM4</accession>
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        <submittedName>
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    <organism evidence="12 13">
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309629.1">
        <property type="nucleotide sequence ID" value="NM_001322549.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBM4"/>
    <dbReference type="SMR" id="A0A131MBM4"/>
    <dbReference type="GeneID" id="183919"/>
    <dbReference type="AGR" id="WB:WBGene00017034"/>
    <dbReference type="CTD" id="183919"/>
    <dbReference type="WormBase" id="D1065.1c">
        <property type="protein sequence ID" value="CE51256"/>
        <property type="gene ID" value="WBGene00017034"/>
        <property type="gene designation" value="otpl-2"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017034">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBM4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF40">
        <property type="entry name" value="OTOPETRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CZR14553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="D1065.1c"/>
        </source>
    </evidence>
    <sequence length="103" mass="11649" checksum="6718E61A4F03AC0F" modified="2016-05-11" version="1">MRSSPLSNKQPGKQVITFLLICNINLFIYHTFETTESSFGFPAKVSEVYTVMLTIASPIVVFYRFHSSACLAEIWKNTYLRNGHDANVGPADSNEKLMMIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBM6</accession>
    <name>A0A131MBM6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">che-7</name>
        <name evidence="12" type="synonym">inx</name>
        <name evidence="14" type="ORF">CELE_F26D11.10</name>
        <name evidence="16" type="ORF">F26D11.10</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
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        <source>
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        </source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00023303"/>
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        <source>
            <dbReference type="RuleBase" id="RU010713"/>
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    <sequence length="560" mass="65206" checksum="779175E55EB9BBBB" modified="2016-05-11" version="1"> </sequence>
</entry>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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        </location>
    </feature>
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            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CZR14504.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MBP2"/>
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    </evidence>
    <sequence length="283" mass="30813" checksum="DBB24AF92D4755DF" modified="2016-05-11" version="1">MFSAQLVGDYVLQLELSYKISEDGILVTKSTMLEVGVTAKEPFTVTSTVMNMNGIPMTSILNNCDHILNASIQSAASIVISSVEFLMADVVTLCDTINGGSGKNLNDKVHSEEVICYSAVIRVLVKEDESETPLGRMSVEWRRAVPNSCPVRSVAPLCRIPVLACPISISSHIKTNPAIVRQPIEICFELKSHSKEAVEISTNFDLNDVFMFSGERKVTMTVLPGATRRVTVVVMALSAGRLNFPKISLKSPQISDQTLQQSLRTLPAAIFVLPKAKDLAPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBQ1</accession>
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        <submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBQ1"/>
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    </dbReference>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CZR14514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C16C10.7d"/>
        </source>
    </evidence>
    <sequence length="100" mass="10358" checksum="BFD3C5E736BD3DF6" modified="2016-05-11" version="1">MMGGGGPNVHFSFGIGIFPLSFVASFFGNGNQGAAAAGGGNGGGNDGNDGTHAHTHGHTHGPRGHGESAAPGSRMAQEEEYLSNIFKYIGFFMLFWLLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBQ3</accession>
    <name>A0A131MBQ3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">che-7</name>
        <name evidence="12" type="synonym">inx</name>
        <name evidence="14" type="ORF">CELE_F26D11.10</name>
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    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
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        <property type="protein sequence ID" value="CZR14557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBQ3"/>
    <dbReference type="SMR" id="A0A131MBQ3"/>
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    <dbReference type="AGR" id="WB:WBGene00000488"/>
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        <property type="protein sequence ID" value="CE51310"/>
        <property type="gene ID" value="WBGene00000488"/>
        <property type="gene designation" value="che-7"/>
    </dbReference>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
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        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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            <dbReference type="ARBA" id="ARBA00022949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="T26H2.2b"/>
        </source>
    </evidence>
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</entry>
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            <begin position="48"/>
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        </location>
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        </source>
    </evidence>
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        </source>
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    <sequence length="95" mass="10783" checksum="D3381C4618FE71E8" modified="2016-05-11" version="1">MQPIEPMLYESTGLLEYDYQTRSYMGSSQGTRSMTYANVPYPEPPQPSYHSNWNSLQRQSNNNTSPQHHLSTFINPNMGVRAGPINYAQLDGDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DQ22</accession>
    <name>A0A3B1DQ22_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">spin-4</name>
        <name evidence="8" type="ORF">CELE_Y111B2A.19</name>
        <name evidence="10" type="ORF">Y111B2A.19</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="VAX62856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368702.1">
        <property type="nucleotide sequence ID" value="NM_001379966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1DQ22"/>
    <dbReference type="SMR" id="A0A3B1DQ22"/>
    <dbReference type="GeneID" id="190952"/>
    <dbReference type="KEGG" id="cel:CELE_Y111B2A.19"/>
    <dbReference type="AGR" id="WB:WBGene00013739"/>
    <dbReference type="CTD" id="190952"/>
    <dbReference type="WormBase" id="Y111B2A.19b">
        <property type="protein sequence ID" value="CE52767"/>
        <property type="gene ID" value="WBGene00013739"/>
        <property type="gene designation" value="spin-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013739">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1DQ22">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VAX62856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y111B2A.19b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A3B1DQ22"/>
        </source>
    </evidence>
    <sequence length="360" mass="39409" checksum="1E06FC47148E1B4A" modified="2018-12-05" version="1">MMFYFAIPVGSGLGFISGSSISQATDSWQWGVRFSPIIGIACLGLMLWLLDEPVRGACDGARQNGDEADLIGDIKYLMSIKTFYLASAASIASFFSIGTMSWWTPQYVGFSYAVIHNVPKVPETELTQINLIFGIITCMAGLLGVATGSILSRAWRDGSSIFRNHATEKADVYICALSMFVALPFLFFAIFIAEYSTNGCLILIYFAIMSMCLNWSVNVDVLMYVVVANRRATALAVQTMVAHLFGDAASPYIIGVLSDMLRGDDASAVGHFFALQKALYVPTFMLVVAGAFYLAATFFVEDDRKEALYQMDAPDNWHHDDPSEDLDDLLSHENPETVEGVEEHPADMIVPLAHSDGDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P6NP92</accession>
    <name>A0A3P6NP92_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">AcetylCholine Receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">acr-21</name>
        <name evidence="19" type="ORF">CELE_F27B3.2</name>
        <name evidence="21" type="ORF">F27B3.2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="VDJ63121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355513.1">
        <property type="nucleotide sequence ID" value="NM_001368431.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P6NP92"/>
    <dbReference type="SMR" id="A0A3P6NP92"/>
    <dbReference type="PaxDb" id="6239-F27B3.2"/>
    <dbReference type="GeneID" id="185004"/>
    <dbReference type="AGR" id="WB:WBGene00000060"/>
    <dbReference type="CTD" id="185004"/>
    <dbReference type="WormBase" id="F27B3.2b">
        <property type="protein sequence ID" value="CE52901"/>
        <property type="gene ID" value="WBGene00000060"/>
        <property type="gene designation" value="acr-21"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3P6NP92">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000030">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 15" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022267630" evidence="15">
        <location>
            <begin position="20"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="33"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="245"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="448"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDJ63121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WormBase" id="F27B3.2b"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="2">Isoform b of Serine/threonine-protein phosphatase 6 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 6" type="primary">saps-1</name>
        <name evidence="6" type="ORF">C47G2.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Development" volume="137" first="237" last="247">
            <title>Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos.</title>
            <authorList>
                <person name="Afshar K."/>
                <person name="Werner M.E."/>
                <person name="Tse Y.C."/>
                <person name="Glotzer M."/>
                <person name="Goenczy P."/>
            </authorList>
            <dbReference type="PubMed" id="20040490"/>
            <dbReference type="DOI" id="10.1242/dev.042754"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN A COMPLEX WITH PPH-6</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2016" name="Development" volume="143" first="2689" last="2689">
            <authorList>
                <person name="Afshar K."/>
                <person name="Werner M.E."/>
                <person name="Tse Y.C."/>
                <person name="Glotzer M."/>
                <person name="Goenczy P."/>
            </authorList>
            <dbReference type="PubMed" id="27436042"/>
            <dbReference type="DOI" id="10.1242/dev.141515"/>
        </citation>
        <scope>ERRATUM OF PUBMED:20040490</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2016" name="J. Cell Sci." volume="129" first="3015" last="3025">
            <title>Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells.</title>
            <authorList>
                <person name="Kotak S."/>
                <person name="Afshar K."/>
                <person name="Busso C."/>
                <person name="Goenczy P."/>
            </authorList>
            <dbReference type="PubMed" id="27335426"/>
            <dbReference type="DOI" id="10.1242/jcs.184416"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH AIR-1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>B2D6K9-3</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_060067 VSP_060068"/>
        </isoform>
        <isoform>
            <id>B2D6K9-1</id>
            <name evidence="6">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>B2D6K9-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_060067"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001122596.1">
        <property type="nucleotide sequence ID" value="NM_001129124.5"/>
    </dbReference>
    <dbReference type="WormBase" id="C47G2.5b">
        <property type="protein sequence ID" value="CE41110"/>
        <property type="gene ID" value="WBGene00008166"/>
        <property type="gene designation" value="saps-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="20040490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C47G2.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C47G2.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C47G2.5c"/>
        </source>
    </evidence>
    <sequence length="717" mass="80477" checksum="7982D937AD7CE797" modified="2008-05-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-10-14" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B5D5N5</accession>
    <name>B5D5N5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Myotubularin phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y71H2AM.6</name>
        <name evidence="1 3" type="ORF">Y71H2AM.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129843.1">
        <property type="nucleotide sequence ID" value="NM_001136371.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5D5N5"/>
    <dbReference type="PeptideAtlas" id="B5D5N5"/>
    <dbReference type="GeneID" id="175394"/>
    <dbReference type="KEGG" id="cel:CELE_Y71H2AM.6"/>
    <dbReference type="AGR" id="WB:WBGene00022171"/>
    <dbReference type="CTD" id="175394"/>
    <dbReference type="WormBase" id="Y71H2AM.6b">
        <property type="protein sequence ID" value="CE43039"/>
        <property type="gene ID" value="WBGene00022171"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2361620_0_0_1"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022171">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5D5N5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD73882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y71H2AM.6b"/>
        </source>
    </evidence>
    <sequence length="96" mass="10992" checksum="947CA600DA91EFF3" modified="2008-10-14" version="1">MSSDDEIESFLKKQQNIPIVFITNSERRNSSAAGKEHCPLYRQFFDGNSWSSECRIFPASRLRGDLHAPRGVPEAVLQAFSEYFQFAEARWGECCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-10-14" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>B5D5N6</accession>
    <name>B5D5N6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_Y51F10.4</name>
        <name evidence="10 12" type="ORF">Y51F10.4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD73476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001032989.1">
        <property type="nucleotide sequence ID" value="NM_001037900.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5D5N6"/>
    <dbReference type="PeptideAtlas" id="B5D5N6"/>
    <dbReference type="GeneID" id="245996"/>
    <dbReference type="AGR" id="WB:WBGene00021765"/>
    <dbReference type="CTD" id="245996"/>
    <dbReference type="WormBase" id="Y51F10.4b">
        <property type="protein sequence ID" value="CE39054"/>
        <property type="gene ID" value="WBGene00021765"/>
    </dbReference>
    <dbReference type="OrthoDB" id="513400at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021765">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5D5N6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF646">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="50"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD73476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y51F10.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="B5D5N6"/>
        </source>
    </evidence>
    <sequence length="425" mass="46330" checksum="B859FA2652CBA60D" modified="2008-10-14" version="1">MKKREKDDEERLLYRKHYTSGTGSSAVLIEDHDSSDSEDTTVSILDPSFTPWPHVFNLANCIIGVSVLAMPYVFQQCGILLAAIMIALCAVLTKLTCHFLAHAAFNTRTTSYESLAMATLGPSGRRFVELCLLVYLVSSIVAFIVVIGDIGPHLVAEFLELEAPTQRLRILVMKESITHTVDLEKFTFHILTAVILLFNTILAILTPNVEFILGLTGAFIGSLVATILPSTIYIANQSASDKINRATRKVNEAAAATSSTAKMCLIIGLFILIASTCAILMGEKKTSVVEKPKAKDDSGEIRHEELKSLESLEEKVLDANLNISAKLDDISELAAKGNDTEAVKMLVEMKEQQKIQQELIVRQEQIVAQLNKKSEILANATAEGEAASEAAKIPEKLAPPENVETMEKEGKAAAESEKKAVNTET</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C0HKD7</accession>
    <accession>P46579</accession>
    <accession>Q5TYM1</accession>
    <accession>Q7Z259</accession>
    <name>PEX10_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisome biogenesis factor 10</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">prx-10</name>
        <name evidence="10" type="ORF">C34E10.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Proc. Natl. Acad. Sci. U.S.A." volume="107" first="4640" last="4645">
            <title>Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhang S.O."/>
                <person name="Box A.C."/>
                <person name="Xu N."/>
                <person name="Le Men J."/>
                <person name="Yu J."/>
                <person name="Guo F."/>
                <person name="Trimble R."/>
                <person name="Mak H.Y."/>
            </authorList>
            <dbReference type="PubMed" id="20176933"/>
            <dbReference type="DOI" id="10.1073/pnas.0912308107"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 9">E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5/prx-5 receptor from peroxisomes to the cytosol, thereby promoting PEX5/prx-5 recycling (Probable) (PubMed:20176933). The retrotranslocation channel is composed of PEX2/prx-2, PEX10/prx-10 and PEX12/prx-12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5/prx-5 through the peroxisomal membrane (By similarity). PEX10/prx-10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity). When PEX5/prx-5 recycling is compromised, PEX10/prx-10 catalyzes polyubiquitination of PEX5/prx-5 during its passage through the retrotranslocation channel, leading to its degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">The E3 ubiquitin-protein ligase activity is stimulated by PEX12/prx-12.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the PEX2-PEX10-PEX12 retrotranslocation channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The three subunits of the retrotranslocation channel (PEX2/prx-2, PEX10/prx-10 and PEX12/prx-12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5/prx-5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Complex locus in which transcription results in the production of one large primary transcript that gives rise to two functionally distinct proteins, wars-2 and prx-10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD66656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021200.2">
        <property type="nucleotide sequence ID" value="NM_001026029.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C0HKD7"/>
    <dbReference type="SMR" id="C0HKD7"/>
    <dbReference type="EnsemblMetazoa" id="C34E10.4a.1">
        <property type="protein sequence ID" value="C34E10.4a.1"/>
        <property type="gene ID" value="WBGene00006946"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="C34E10.4a.2">
        <property type="protein sequence ID" value="C34E10.4a.2"/>
        <property type="gene ID" value="WBGene00006946"/>
    </dbReference>
    <dbReference type="GeneID" id="175719"/>
    <dbReference type="KEGG" id="cel:CELE_C34E10.4"/>
    <dbReference type="AGR" id="WB:WBGene00006946"/>
    <dbReference type="CTD" id="175719"/>
    <dbReference type="WormBase" id="C34E10.4a">
        <property type="protein sequence ID" value="CE44834"/>
        <property type="gene ID" value="WBGene00006946"/>
        <property type="gene designation" value="prx-10"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006946">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C0HKD7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0576">Peroxisome</keyword>
    <keyword id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000441752" description="Peroxisome biogenesis factor 10" evidence="8">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="topological domain" description="Peroxisomal matrix" evidence="1">
        <location>
            <begin position="1"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=TM1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=TM2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="topological domain" description="Peroxisomal matrix" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=TM3" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=TM4" evidence="2">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="topological domain" description="Peroxisomal matrix" evidence="1">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=TM5" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="219"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-type" evidence="6">
        <location>
            <begin position="255"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="G2Q0E2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="G2Q1C9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="O60683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q05568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5"/>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="20176933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="C34E10.4a"/>
        </source>
    </evidence>
    <sequence length="314" mass="36002" checksum="2C8D62CA3591EA85" modified="2017-10-25" version="1">MNTYVAEIGEIVRSQRRDEEYIEDITERLSRVSKELLGQRTWIRWFPYLKSIASTLYYTSTVVLGNQTLGEEYVHLFESNGLERTVPSIPSRISFVLLHSAFPLISNYLIQKAESTLTHPSTESFLGIPIRKNQKARQSFLDVFFWLRTKLFPQLQRAHIALFYITGAYYSIARRFTGIRFLSASAHSDIPALKVYRFLGYITLIQLAVSIGISLYSFLEQEKFNNKLKKEKKENNGGSDRNLDENSLFHPTFQCSICLENKNPSALFCGHLFCWTCIQEHAVAATSSASTSSARCPQCRLEFQPRDVTPLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-01-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>D1MN44</accession>
    <name>D1MN44_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SID1 transmembrane family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="ORF">C08A9.3</name>
        <name evidence="9" type="ORF">CELE_C08A9.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SID1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257283.1">
        <property type="nucleotide sequence ID" value="NM_001270354.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D1MN44"/>
    <dbReference type="SMR" id="D1MN44"/>
    <dbReference type="GeneID" id="182383"/>
    <dbReference type="KEGG" id="cel:CELE_C08A9.3"/>
    <dbReference type="AGR" id="WB:WBGene00015583"/>
    <dbReference type="CTD" id="182383"/>
    <dbReference type="WormBase" id="C08A9.3a">
        <property type="protein sequence ID" value="CE44330"/>
        <property type="gene ID" value="WBGene00015583"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023265_0_0_1"/>
    <dbReference type="OrthoDB" id="5870790at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D1MN44">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025958">
        <property type="entry name" value="SID1_TM_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185:SF18">
        <property type="entry name" value="SID1 TRANSMEMBRANE FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185">
        <property type="entry name" value="SID1 TRANSMEMBRANE FAMILY MEMEBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13965">
        <property type="entry name" value="SID-1_RNA_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD63619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C08A9.3a"/>
        </source>
    </evidence>
    <sequence length="694" mass="79536" checksum="FD22CDA09FD02B11" modified="2010-01-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2026-01-28" version="168" xmlns="https://uniprot.org/uniprot">
    <accession>P30645-3</accession>
    <name>PDE2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Probable 3',5'-cyclic phosphodiesterase pde-2</fullName>
            <ecNumber>3.1.4.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pde-2</name>
        <name evidence="1" type="ORF">R08D7.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
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                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="Genetics" volume="201" first="1497" last="1510">
            <title>The importance of cGMP signaling in sensory cilia for body size regulation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Fujiwara M."/>
                <person name="Hino T."/>
                <person name="Miyamoto R."/>
                <person name="Inada H."/>
                <person name="Mori I."/>
                <person name="Koga M."/>
                <person name="Miyahara K."/>
                <person name="Ohshima Y."/>
                <person name="Ishihara T."/>
            </authorList>
            <dbReference type="PubMed" id="26434723"/>
            <dbReference type="DOI" id="10.1534/genetics.115.177543"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P30645-3</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_014355"/>
        </isoform>
        <isoform>
            <id>P30645-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.4.17"/>
    <dbReference type="RefSeq" id="NP_001022706.2">
        <property type="nucleotide sequence ID" value="NM_001027535.7"/>
    </dbReference>
    <dbReference type="WormBase" id="R08D7.6b">
        <property type="protein sequence ID" value="CE44922"/>
        <property type="gene ID" value="WBGene00011146"/>
        <property type="gene designation" value="pde-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="R08D7.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="R08D7.6b"/>
        </source>
    </evidence>
    <sequence length="828" mass="94017" checksum="6C8B0F649C7E09D5" modified="2011-07-27" version="4"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-07-01" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>Q01630-2</accession>
    <name>UNC33_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Protein unc-33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inactive dihydropyrimidinase unc-33</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Uncoordinated protein 33</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">unc-33</name>
        <name evidence="8" type="ORF">Y37E11C.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Genetics" volume="132" first="675" last="689">
            <title>Analysis of the Caenorhabditis elegans axonal guidance and outgrowth gene unc-33.</title>
            <authorList>
                <person name="Li W."/>
                <person name="Herman R.K."/>
                <person name="Shaw J.E."/>
            </authorList>
            <dbReference type="PubMed" id="1468626"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
            <tissue>Embryo</tissue>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Dev. Biol." volume="226" first="137" last="151">
            <title>Mechanisms controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites.</title>
            <authorList>
                <person name="Branda C.S."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="10993679"/>
            <dbReference type="DOI" id="10.1006/dbio.2000.9853"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Development" volume="128" first="1951" last="1969">
            <title>A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans.</title>
            <authorList>
                <person name="Altun-Gultekin Z."/>
                <person name="Andachi Y."/>
                <person name="Tsalik E.L."/>
                <person name="Pilgrim D."/>
                <person name="Kohara Y."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="11493519"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF ASP-389</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="J. Neurochem." volume="95" first="1629" last="1641">
            <title>Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tsuboi D."/>
                <person name="Hikita T."/>
                <person name="Qadota H."/>
                <person name="Amano M."/>
                <person name="Kaibuchi K."/>
            </authorList>
            <dbReference type="PubMed" id="16236031"/>
            <dbReference type="DOI" id="10.1111/j.1471-4159.2005.03490.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>INTERACTION WITH UNC-14 AND KLC-2</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY (ISOFORM A)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ASP-389</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="Nat. Neurosci." volume="15" first="48" last="56">
            <title>UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting.</title>
            <authorList>
                <person name="Maniar T.A."/>
                <person name="Kaplan M."/>
                <person name="Wang G.J."/>
                <person name="Shen K."/>
                <person name="Wei L."/>
                <person name="Shaw J.E."/>
                <person name="Koushika S.P."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="22101643"/>
            <dbReference type="DOI" id="10.1038/nn.2970"/>
        </citation>
        <scope>FUNCTION (ISOFORM A)</scope>
        <scope>SUBCELLULAR LOCATION (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY (ISOFORM A)</scope>
        <scope>MUTAGENESIS OF 255-GLU--TRP-854; ASP-389 AND GLU-663</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2014" name="Development" volume="141" first="4395" last="4405">
            <title>The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP.</title>
            <authorList>
                <person name="Norris A.D."/>
                <person name="Sundararajan L."/>
                <person name="Morgan D.E."/>
                <person name="Roberts Z.J."/>
                <person name="Lundquist E.A."/>
            </authorList>
            <dbReference type="PubMed" id="25371370"/>
            <dbReference type="DOI" id="10.1242/dev.110437"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ASP-389</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="5325" last="5325">
            <title>Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling.</title>
            <authorList>
                <person name="Nakamura F."/>
                <person name="Kumeta K."/>
                <person name="Hida T."/>
                <person name="Isono T."/>
                <person name="Nakayama Y."/>
                <person name="Kuramata-Matsuoka E."/>
                <person name="Yamashita N."/>
                <person name="Uchida Y."/>
                <person name="Ogura K."/>
                <person name="Gengyo-Ando K."/>
                <person name="Mitani S."/>
                <person name="Ogino T."/>
                <person name="Goshima Y."/>
            </authorList>
            <dbReference type="PubMed" id="25358863"/>
            <dbReference type="DOI" id="10.1038/ncomms6325"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH FLN-1</scope>
        <scope>MUTAGENESIS OF ASP-389</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1005948" last="E1005948">
            <title>Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.</title>
            <authorList>
                <person name="Meng L."/>
                <person name="Chen C.H."/>
                <person name="Yan D."/>
            </authorList>
            <dbReference type="PubMed" id="27015090"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005948"/>
        </citation>
        <scope>FUNCTION (ISOFORMS A; B AND C)</scope>
        <scope>INTERACTION WITH VAB-8</scope>
        <scope>MUTAGENESIS OF GLU-168; GLY-328 AND ASP-389</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2018" name="Genetics" volume="210" first="235" last="255">
            <title>Control of Growth Cone Polarity, Microtubule Accumulation, and Protrusion by UNC-6/Netrin and Its Receptors in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gujar M.R."/>
                <person name="Sundararajan L."/>
                <person name="Stricker A."/>
                <person name="Lundquist E.A."/>
            </authorList>
            <dbReference type="PubMed" id="30045855"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301234"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ASP-389</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2018" name="J. Cell Sci." volume="131" first="0" last="0">
            <title>Local microtubule organization promotes cargo transport in C. elegans dendrites.</title>
            <authorList>
                <person name="Harterink M."/>
                <person name="Edwards S.L."/>
                <person name="de Haan B."/>
                <person name="Yau K.W."/>
                <person name="van den Heuvel S."/>
                <person name="Kapitein L.C."/>
                <person name="Miller K.G."/>
                <person name="Hoogenraad C.C."/>
            </authorList>
            <dbReference type="PubMed" id="30254025"/>
            <dbReference type="DOI" id="10.1242/jcs.223107"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">In PLM neuron, regulates innexin unc-9 gap junction turnover by suppressing unc-9 transport out of gap junctions.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q01630-1</id>
            <name evidence="8">a</name>
            <name evidence="6">L</name>
            <name evidence="5">I</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q01630-2</id>
            <name evidence="9">b</name>
            <name evidence="6">M</name>
            <name evidence="5">II</name>
            <sequence type="described" ref="VSP_001310"/>
        </isoform>
        <isoform>
            <id>Q01630-3</id>
            <name evidence="7">c</name>
            <name evidence="6">S</name>
            <name evidence="5">III</name>
            <sequence type="described" ref="VSP_001311"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001368216.1">
        <property type="nucleotide sequence ID" value="NM_001380147.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y37E11C.1b">
        <property type="protein sequence ID" value="CE31638"/>
        <property type="gene ID" value="WBGene00006769"/>
        <property type="gene designation" value="unc-33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <feature type="mutagenesis site" description="In e204; uncoordinated. In AIY, ASI, D-type neurons, impairs axonal guidance and outgrowth and in some cases causes ectopic axonal branching. In VD neurons, increases growth cone filopodial protrusion associated with a loss of F-actin polarity and an accumulation of plus-end microtubule in the growth cone. Causes mislocalization of several axonal and dendrite proteins. In the PLM neuron axon, increases the number of unc-9 puncta close to the two original gap junctions and the length of the first gap junction. Causes unc-33 mislocalization to the perikaryon. Reduces its expression, homodimerization and heterodimerization; in isoform b. Prevents homodimerization and heterodimerization; in isoform c." evidence="1 2 3">
        <original>D</original>
        <variation>N</variation>
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="11493519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16236031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="22101643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="27015090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="1468626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="16236031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y37E11C.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="Y37E11C.1b"/>
        </source>
    </evidence>
    <sequence length="679" mass="72128" checksum="6AA501F222B1F812" modified="1993-07-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-07-01" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>Q01630-3</accession>
    <name>UNC33_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Protein unc-33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inactive dihydropyrimidinase unc-33</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Uncoordinated protein 33</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">unc-33</name>
        <name evidence="8" type="ORF">Y37E11C.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Genetics" volume="132" first="675" last="689">
            <title>Analysis of the Caenorhabditis elegans axonal guidance and outgrowth gene unc-33.</title>
            <authorList>
                <person name="Li W."/>
                <person name="Herman R.K."/>
                <person name="Shaw J.E."/>
            </authorList>
            <dbReference type="PubMed" id="1468626"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
            <tissue>Embryo</tissue>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Dev. Biol." volume="226" first="137" last="151">
            <title>Mechanisms controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites.</title>
            <authorList>
                <person name="Branda C.S."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="10993679"/>
            <dbReference type="DOI" id="10.1006/dbio.2000.9853"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Development" volume="128" first="1951" last="1969">
            <title>A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans.</title>
            <authorList>
                <person name="Altun-Gultekin Z."/>
                <person name="Andachi Y."/>
                <person name="Tsalik E.L."/>
                <person name="Pilgrim D."/>
                <person name="Kohara Y."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="11493519"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF ASP-389</scope>
    </reference>
    <reference key="5">
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            <title>Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tsuboi D."/>
                <person name="Hikita T."/>
                <person name="Qadota H."/>
                <person name="Amano M."/>
                <person name="Kaibuchi K."/>
            </authorList>
            <dbReference type="PubMed" id="16236031"/>
            <dbReference type="DOI" id="10.1111/j.1471-4159.2005.03490.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>INTERACTION WITH UNC-14 AND KLC-2</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY (ISOFORM A)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ASP-389</scope>
    </reference>
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        <citation type="journal article" date="2011" name="Nat. Neurosci." volume="15" first="48" last="56">
            <title>UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting.</title>
            <authorList>
                <person name="Maniar T.A."/>
                <person name="Kaplan M."/>
                <person name="Wang G.J."/>
                <person name="Shen K."/>
                <person name="Wei L."/>
                <person name="Shaw J.E."/>
                <person name="Koushika S.P."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="22101643"/>
            <dbReference type="DOI" id="10.1038/nn.2970"/>
        </citation>
        <scope>FUNCTION (ISOFORM A)</scope>
        <scope>SUBCELLULAR LOCATION (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY (ISOFORM A)</scope>
        <scope>MUTAGENESIS OF 255-GLU--TRP-854; ASP-389 AND GLU-663</scope>
    </reference>
    <reference key="7">
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            <title>The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP.</title>
            <authorList>
                <person name="Norris A.D."/>
                <person name="Sundararajan L."/>
                <person name="Morgan D.E."/>
                <person name="Roberts Z.J."/>
                <person name="Lundquist E.A."/>
            </authorList>
            <dbReference type="PubMed" id="25371370"/>
            <dbReference type="DOI" id="10.1242/dev.110437"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ASP-389</scope>
    </reference>
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            <title>Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling.</title>
            <authorList>
                <person name="Nakamura F."/>
                <person name="Kumeta K."/>
                <person name="Hida T."/>
                <person name="Isono T."/>
                <person name="Nakayama Y."/>
                <person name="Kuramata-Matsuoka E."/>
                <person name="Yamashita N."/>
                <person name="Uchida Y."/>
                <person name="Ogura K."/>
                <person name="Gengyo-Ando K."/>
                <person name="Mitani S."/>
                <person name="Ogino T."/>
                <person name="Goshima Y."/>
            </authorList>
            <dbReference type="PubMed" id="25358863"/>
            <dbReference type="DOI" id="10.1038/ncomms6325"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH FLN-1</scope>
        <scope>MUTAGENESIS OF ASP-389</scope>
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            <title>Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.</title>
            <authorList>
                <person name="Meng L."/>
                <person name="Chen C.H."/>
                <person name="Yan D."/>
            </authorList>
            <dbReference type="PubMed" id="27015090"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005948"/>
        </citation>
        <scope>FUNCTION (ISOFORMS A; B AND C)</scope>
        <scope>INTERACTION WITH VAB-8</scope>
        <scope>MUTAGENESIS OF GLU-168; GLY-328 AND ASP-389</scope>
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    <reference key="10">
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            <title>Control of Growth Cone Polarity, Microtubule Accumulation, and Protrusion by UNC-6/Netrin and Its Receptors in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gujar M.R."/>
                <person name="Sundararajan L."/>
                <person name="Stricker A."/>
                <person name="Lundquist E.A."/>
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            <dbReference type="PubMed" id="30045855"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301234"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ASP-389</scope>
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            <title>Local microtubule organization promotes cargo transport in C. elegans dendrites.</title>
            <authorList>
                <person name="Harterink M."/>
                <person name="Edwards S.L."/>
                <person name="de Haan B."/>
                <person name="Yau K.W."/>
                <person name="van den Heuvel S."/>
                <person name="Kapitein L.C."/>
                <person name="Miller K.G."/>
                <person name="Hoogenraad C.C."/>
            </authorList>
            <dbReference type="PubMed" id="30254025"/>
            <dbReference type="DOI" id="10.1242/jcs.223107"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
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        <text evidence="4">In PLM neuron, regulates innexin unc-9 gap junction turnover by suppressing unc-9 transport out of gap junctions.</text>
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            <fullName>Intermediate filament protein B2</fullName>
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    <reference key="1">
        <citation type="journal article" date="1994" name="EMBO J." volume="13" first="2625" last="2638">
            <title>Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dodemont H."/>
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                <person name="Ledger T.N."/>
                <person name="Weber K."/>
            </authorList>
            <dbReference type="PubMed" id="8013462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND C)</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Proc. Natl. Acad. Sci. U.S.A." volume="98" first="7863" last="7868">
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                <person name="Weber K."/>
            </authorList>
            <dbReference type="PubMed" id="11427699"/>
            <dbReference type="DOI" id="10.1073/pnas.121169998"/>
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        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
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            <title>The apical disposition of the Caenorhabditis elegans intestinal terminal web is maintained by LET-413.</title>
            <authorList>
                <person name="Bossinger O."/>
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            </authorList>
            <dbReference type="PubMed" id="15063180"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2004.01.003"/>
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        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19286-2</id>
            <name>c</name>
            <name>b2-L</name>
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        <isoform>
            <id>Q19286-1</id>
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    <protein>
        <recommendedName>
            <fullName>Isoform a of Vacuolar protein sorting-associated protein 41 homolog</fullName>
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        <name evidence="1" type="primary">vps-41</name>
        <name evidence="1" type="ORF">F32A6.3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
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            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    <reference key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
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            <title>Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.</title>
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        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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        <scope>FUNCTION</scope>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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            <title>Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans.</title>
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                <person name="Solinger J.A."/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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            <dbReference type="DOI" id="10.1083/jcb.201506081"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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                <person name="Liu K."/>
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            <dbReference type="DOI" id="10.1083/jcb.20150608103012016c"/>
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        <scope>ERRATUM OF PUBMED:26783301</scope>
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    <comment type="alternative products">
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    <dbReference type="RefSeq" id="NP_001370495.1">
        <property type="nucleotide sequence ID" value="NM_001383575.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F32A6.3a">
        <property type="protein sequence ID" value="CE37009"/>
        <property type="gene ID" value="WBGene00017974"/>
        <property type="gene designation" value="vps-41"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="F32A6.3c"/>
        </source>
    </evidence>
    <sequence length="759" mass="86688" checksum="F23891404DD6E9E8" modified="2007-08-21" version="4"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q19954-3</accession>
    <name>VPS41_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Vacuolar protein sorting-associated protein 41 homolog</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="primary">vps-41</name>
        <name evidence="1" type="ORF">F32A6.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Cancer Cell" volume="7" first="325" last="336">
            <title>Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.</title>
            <authorList>
                <person name="Lackner M.R."/>
                <person name="Kindt R.M."/>
                <person name="Carroll P.M."/>
                <person name="Brown K."/>
                <person name="Cancilla M.R."/>
                <person name="Chen C."/>
                <person name="de Silva H."/>
                <person name="Franke Y."/>
                <person name="Guan B."/>
                <person name="Heuer T."/>
                <person name="Hung T."/>
                <person name="Keegan K."/>
                <person name="Lee J.M."/>
                <person name="Manne V."/>
                <person name="O'Brien C."/>
                <person name="Parry D."/>
                <person name="Perez-Villar J.J."/>
                <person name="Reddy R.K."/>
                <person name="Xiao H."/>
                <person name="Zhan H."/>
                <person name="Cockett M."/>
                <person name="Plowman G."/>
                <person name="Fitzgerald K."/>
                <person name="Costa M."/>
                <person name="Ross-Macdonald P."/>
            </authorList>
            <dbReference type="PubMed" id="15837622"/>
            <dbReference type="DOI" id="10.1016/j.ccr.2005.03.024"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Nat. Cell Biol." volume="8" first="793" last="802">
            <title>The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing.</title>
            <authorList>
                <person name="Saleh M.-C."/>
                <person name="van Rij R.P."/>
                <person name="Hekele A."/>
                <person name="Gillis A."/>
                <person name="Foley E."/>
                <person name="O'Farrell P.H."/>
                <person name="Andino R."/>
            </authorList>
            <dbReference type="PubMed" id="16862146"/>
            <dbReference type="DOI" id="10.1038/ncb1439"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2014" name="Dev. Cell" volume="28" first="43" last="55">
            <title>The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39.</title>
            <authorList>
                <person name="Manil-Segalen M."/>
                <person name="Lefebvre C."/>
                <person name="Jenzer C."/>
                <person name="Trichet M."/>
                <person name="Boulogne C."/>
                <person name="Satiat-Jeunemaitre B."/>
                <person name="Legouis R."/>
            </authorList>
            <dbReference type="PubMed" id="24374177"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2013.11.022"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="Mol. Biol. Cell" volume="25" first="1073" last="1096">
            <title>Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1.</title>
            <authorList>
                <person name="Delahaye J.L."/>
                <person name="Foster O.K."/>
                <person name="Vine A."/>
                <person name="Saxton D.S."/>
                <person name="Curtin T.P."/>
                <person name="Somhegyi H."/>
                <person name="Salesky R."/>
                <person name="Hermann G.J."/>
            </authorList>
            <dbReference type="PubMed" id="24501423"/>
            <dbReference type="DOI" id="10.1091/mbc.E13-09-0521"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2014" name="Mol. Biol. Cell" volume="25" first="3909" last="3925">
            <title>Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Solinger J.A."/>
                <person name="Spang A."/>
            </authorList>
            <dbReference type="PubMed" id="25273556"/>
            <dbReference type="DOI" id="10.1091/mbc.E13-12-0710"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2016" name="J. Cell Biol." volume="212" first="181" last="198">
            <title>Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.</title>
            <authorList>
                <person name="Liu K."/>
                <person name="Jian Y."/>
                <person name="Sun X."/>
                <person name="Yang C."/>
                <person name="Gao Z."/>
                <person name="Zhang Z."/>
                <person name="Liu X."/>
                <person name="Li Y."/>
                <person name="Xu J."/>
                <person name="Jing Y."/>
                <person name="Mitani S."/>
                <person name="He S."/>
                <person name="Yang C."/>
            </authorList>
            <dbReference type="PubMed" id="26783301"/>
            <dbReference type="DOI" id="10.1083/jcb.201506081"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2016" name="J. Cell Biol." volume="212" first="739" last="739">
            <title>Correction: Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.</title>
            <authorList>
                <person name="Liu K."/>
                <person name="Jian Y."/>
                <person name="Sun X."/>
                <person name="Yang C."/>
                <person name="Gao Z."/>
                <person name="Zhang Z."/>
                <person name="Liu X."/>
                <person name="Li Y."/>
                <person name="Xu J."/>
                <person name="Jing Y."/>
                <person name="Mitani S."/>
                <person name="He S."/>
                <person name="Yang C."/>
            </authorList>
            <dbReference type="PubMed" id="26975852"/>
            <dbReference type="DOI" id="10.1083/jcb.20150608103012016c"/>
        </citation>
        <scope>ERRATUM OF PUBMED:26783301</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19954-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_027446 VSP_027447 VSP_027445"/>
        </isoform>
        <isoform>
            <id>Q19954-1</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q19954-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_027445"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001370496.1">
        <property type="nucleotide sequence ID" value="NM_001383576.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F32A6.3b">
        <property type="protein sequence ID" value="CE40762"/>
        <property type="gene ID" value="WBGene00017974"/>
        <property type="gene designation" value="vps-41"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="F32A6.3c"/>
        </source>
    </evidence>
    <sequence length="681" mass="78222" checksum="43CBD58C87B845AF" modified="2007-08-21" version="4"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-05-16" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q1T6W7</accession>
    <name>Q1T6W7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">smg-6</name>
        <name evidence="8" type="ORF">CELE_Y54F10AL.2</name>
        <name evidence="10" type="ORF">Y54F10AL.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD68646.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367726.1">
        <property type="nucleotide sequence ID" value="NM_001381779.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1T6W7"/>
    <dbReference type="SMR" id="Q1T6W7"/>
    <dbReference type="PeptideAtlas" id="Q1T6W7"/>
    <dbReference type="GeneID" id="175367"/>
    <dbReference type="KEGG" id="cel:CELE_Y54F10AL.2"/>
    <dbReference type="UCSC" id="Y54F10AL.2c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004884"/>
    <dbReference type="CTD" id="175367"/>
    <dbReference type="WormBase" id="Y54F10AL.2c">
        <property type="protein sequence ID" value="CE54156"/>
        <property type="gene ID" value="WBGene00004884"/>
        <property type="gene designation" value="smg-6"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004884">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1T6W7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030538">
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
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    <dbReference type="GO" id="GO:0035194">
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
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    <dbReference type="CDD" id="cd09885">
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        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
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    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
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    <dbReference type="InterPro" id="IPR045153">
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    <dbReference type="InterPro" id="IPR029060">
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    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF38">
        <property type="entry name" value="PIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00670">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1043"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="487"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1023"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="53"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="87"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="328"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="472"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD68646.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y54F10AL.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q1T6W7"/>
        </source>
    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>Q20646-2</accession>
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    <reference evidence="2 4" key="1">
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                <consortium name="The C. elegans sequencing consortium"/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference evidence="2 3" key="2">
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            <dbReference type="PubMed" id="11696333"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
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            <dbReference type="PubMed" id="11557844"/>
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        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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            <dbReference type="PubMed" id="12445383"/>
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        <scope>FUNCTION</scope>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH APE-1</scope>
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            <dbReference type="PubMed" id="15273685"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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            <dbReference type="PubMed" id="15242600"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS)</scope>
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        <scope>DNA-BINDING</scope>
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        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
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        <scope>FUNCTION</scope>
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        <scope>FUNCTION</scope>
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        <scope>FUNCTION</scope>
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            <title>AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans.</title>
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                <person name="Quevedo C."/>
                <person name="Kaplan D.R."/>
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            <dbReference type="PubMed" id="17276923"/>
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        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2007" name="EMBO J." volume="26" first="3463" last="3473">
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                <person name="Ou H.D."/>
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        <scope>STRUCTURE BY NMR OF 514-644</scope>
        <scope>DIMERIZATION</scope>
        <scope>MUTAGENESIS OF LYS-544; ARG-551 AND GLU-552</scope>
        <scope>ZINC-BINDING SITES</scope>
    </reference>
    <reference evidence="2" key="15">
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            <dbReference type="PubMed" id="17895432"/>
            <dbReference type="DOI" id="10.1093/gerona/62.9.951"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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                <person name="Greiss S."/>
                <person name="Schumacher B."/>
                <person name="Grandien K."/>
                <person name="Rothblatt J."/>
                <person name="Gartner A."/>
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            <dbReference type="DOI" id="10.1186/1471-2164-9-334"/>
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        <scope>FUNCTION</scope>
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                <person name="Masse I."/>
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            <dbReference type="DOI" id="10.1371/journal.pone.0003354"/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PRMT-5 AND CBP-1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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        <scope>DEVELOPMENTAL STAGE</scope>
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        <scope>DISRUPTION PHENOTYPE</scope>
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        <scope>FUNCTION</scope>
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    </evidence>
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            <dbReference type="WormBase" id="R07E3.3b"/>
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    <sequence length="379" mass="43104" checksum="1B85FFB5DEF9827B" modified="2008-06-10" version="3" precursor="true">MNFILAVFAIILLQAVRGEIDNAIVGDPSVECGDDFFEVKFDTRTTFHGLAFVQNHLDNPDCRSFASKTDSAKNSSLRLTFDQCAIEKRHSTSPRGLFLSTNVVVAFNPEFLTKNDRVFKVQCFYMEMERRIQKVIQISMPPPTMHSKQLNMPVCKYEVLDGSPTGPPVYFATVGQMVYHKWTCDTEHENTFCMLVHSCFVDDGNGQRVQLLNDKGCALDKYLLTNLEYPTDLMAGREAHVYKYADRDNMYFDCQISITVKEPGLDYCDVPSCPDPPRRRRSNTLPAPDDNITAIAAHIEYEDSEIISDYIIPNDDIISLNWLQRNFDMRISELCMTAIGTTLLVFLNAFLFIISLVSIVHVCCFRTSPKLEKTKSTML</sequence>
</entry>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
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    <reference key="2">
        <citation type="journal article" date="2017" name="Dev. Cell" volume="43" first="212" last="226">
            <title>Convergent Transcriptional Programs Regulate cAMP Levels in C. elegans GABAergic Motor Neurons.</title>
            <authorList>
                <person name="Yu B."/>
                <person name="Wang X."/>
                <person name="Wei S."/>
                <person name="Fu T."/>
                <person name="Dzakah E.E."/>
                <person name="Waqas A."/>
                <person name="Walthall W.W."/>
                <person name="Shan G."/>
            </authorList>
            <dbReference type="PubMed" id="29033363"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2017.09.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
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            <id>Q22000-4</id>
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        <isoform>
            <id>Q22000-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_014348 VSP_014349"/>
        </isoform>
        <isoform>
            <id>Q22000-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_014353 VSP_014354"/>
        </isoform>
        <isoform>
            <id>Q22000-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_014345 VSP_014352"/>
        </isoform>
        <isoform>
            <id>Q22000-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_014347 VSP_014350"/>
        </isoform>
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            <id>Q22000-1</id>
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        <property type="protein sequence ID" value="CE02038"/>
        <property type="gene ID" value="WBGene00020114"/>
        <property type="gene designation" value="pde-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
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            <dbReference type="UniProtKB" id="P27815"/>
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    <evidence type="ECO:0000305" key="2"/>
    <sequence length="549" mass="62904" checksum="DF2EE6F03925DE87" modified="2005-07-05" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q22000-3</accession>
    <name>PDE4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Probable 3',5'-cyclic-AMP phosphodiesterase pde-4</fullName>
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    <gene>
        <name type="primary">pde-4</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Peloderinae</taxon>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
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    <reference key="2">
        <citation type="journal article" date="2017" name="Dev. Cell" volume="43" first="212" last="226">
            <title>Convergent Transcriptional Programs Regulate cAMP Levels in C. elegans GABAergic Motor Neurons.</title>
            <authorList>
                <person name="Yu B."/>
                <person name="Wang X."/>
                <person name="Wei S."/>
                <person name="Fu T."/>
                <person name="Dzakah E.E."/>
                <person name="Waqas A."/>
                <person name="Walthall W.W."/>
                <person name="Shan G."/>
            </authorList>
            <dbReference type="PubMed" id="29033363"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2017.09.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
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            <id>Q22000-1</id>
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        <isoform>
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            <name>b</name>
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        </isoform>
        <isoform>
            <id>Q22000-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_014353 VSP_014354"/>
        </isoform>
        <isoform>
            <id>Q22000-4</id>
            <name>c</name>
            <sequence type="described" ref="VSP_014346 VSP_014351"/>
        </isoform>
        <isoform>
            <id>Q22000-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_014348 VSP_014349"/>
        </isoform>
        <isoform>
            <id>Q22000-2</id>
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        </isoform>
    </comment>
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    </dbReference>
    <dbReference type="WormBase" id="R153.1e">
        <property type="protein sequence ID" value="CE33439"/>
        <property type="gene ID" value="WBGene00020114"/>
        <property type="gene designation" value="pde-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
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        <source>
            <dbReference type="UniProtKB" id="P27815"/>
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    <evidence type="ECO:0000305" key="2"/>
    <sequence length="612" mass="69498" checksum="5E75F83B7D539255" modified="2005-07-05" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q22000-4</accession>
    <name>PDE4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform c of Probable 3',5'-cyclic-AMP phosphodiesterase pde-4</fullName>
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    <gene>
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        <name type="ORF">R153.1</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="Dev. Cell" volume="43" first="212" last="226">
            <title>Convergent Transcriptional Programs Regulate cAMP Levels in C. elegans GABAergic Motor Neurons.</title>
            <authorList>
                <person name="Yu B."/>
                <person name="Wang X."/>
                <person name="Wei S."/>
                <person name="Fu T."/>
                <person name="Dzakah E.E."/>
                <person name="Waqas A."/>
                <person name="Walthall W.W."/>
                <person name="Shan G."/>
            </authorList>
            <dbReference type="PubMed" id="29033363"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2017.09.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
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            <id>Q22000-5</id>
            <name>e</name>
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            <id>Q22000-4</id>
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            <sequence type="described" ref="VSP_014346 VSP_014351"/>
        </isoform>
        <isoform>
            <id>Q22000-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_014350 VSP_014347"/>
        </isoform>
        <isoform>
            <id>Q22000-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_014352 VSP_014345"/>
        </isoform>
        <isoform>
            <id>Q22000-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_014354 VSP_014353"/>
        </isoform>
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            <id>Q22000-1</id>
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        <property type="gene ID" value="WBGene00020114"/>
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    <dbReference type="Proteomes" id="UP000001940">
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    <evidence type="ECO:0000305" key="2"/>
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</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q22000-5</accession>
    <name>PDE4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform e of Probable 3',5'-cyclic-AMP phosphodiesterase pde-4</fullName>
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        <name type="ORF">R153.1</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
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    <reference key="2">
        <citation type="journal article" date="2017" name="Dev. Cell" volume="43" first="212" last="226">
            <title>Convergent Transcriptional Programs Regulate cAMP Levels in C. elegans GABAergic Motor Neurons.</title>
            <authorList>
                <person name="Yu B."/>
                <person name="Wang X."/>
                <person name="Wei S."/>
                <person name="Fu T."/>
                <person name="Dzakah E.E."/>
                <person name="Waqas A."/>
                <person name="Walthall W.W."/>
                <person name="Shan G."/>
            </authorList>
            <dbReference type="PubMed" id="29033363"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2017.09.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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        <isoform>
            <id>Q22000-4</id>
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        </isoform>
        <isoform>
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        </isoform>
        <isoform>
            <id>Q22000-6</id>
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            <sequence type="described" ref="VSP_014354 VSP_014353"/>
        </isoform>
        <isoform>
            <id>Q22000-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_014352 VSP_014345"/>
        </isoform>
        <isoform>
            <id>Q22000-3</id>
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            <sequence type="described" ref="VSP_014347 VSP_014350"/>
        </isoform>
    </comment>
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    <evidence type="ECO:0000305" key="2"/>
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</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q22000-6</accession>
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            <fullName evidence="2">Isoform f of Probable 3',5'-cyclic-AMP phosphodiesterase pde-4</fullName>
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    <gene>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="Dev. Cell" volume="43" first="212" last="226">
            <title>Convergent Transcriptional Programs Regulate cAMP Levels in C. elegans GABAergic Motor Neurons.</title>
            <authorList>
                <person name="Yu B."/>
                <person name="Wang X."/>
                <person name="Wei S."/>
                <person name="Fu T."/>
                <person name="Dzakah E.E."/>
                <person name="Waqas A."/>
                <person name="Walthall W.W."/>
                <person name="Shan G."/>
            </authorList>
            <dbReference type="PubMed" id="29033363"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2017.09.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q22000-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_014352 VSP_014345"/>
        </isoform>
        <isoform>
            <id>Q22000-1</id>
            <name>d</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q22000-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_014350 VSP_014347"/>
        </isoform>
        <isoform>
            <id>Q22000-4</id>
            <name>c</name>
            <sequence type="described" ref="VSP_014351 VSP_014346"/>
        </isoform>
        <isoform>
            <id>Q22000-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_014349 VSP_014348"/>
        </isoform>
        <isoform>
            <id>Q22000-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_014354 VSP_014353"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.4.53" evidence="1"/>
    <dbReference type="RefSeq" id="NP_871947.1">
        <property type="nucleotide sequence ID" value="NM_182147.5"/>
    </dbReference>
    <dbReference type="WormBase" id="R153.1f">
        <property type="protein sequence ID" value="CE33440"/>
        <property type="gene ID" value="WBGene00020114"/>
        <property type="gene designation" value="pde-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P27815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="158" mass="16407" checksum="119F39EF1F6BEC58" modified="2005-07-05" version="2">MPRRRGSSSSSSAAGGSGGGGGFGFSSLRRELHLHNFFRTSSPSASSTSRTPPAALPPRTSAVTIPGSNHKLTSSASSYHPPRELTVSTFSAGSATAADGLGGAHLTPSLSSSVHARRESFLYRASDDLREASSLRPVSRASSIASNEHGYVILYIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q23117</accession>
    <name>Q23117_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Globin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">glb-27</name>
        <name evidence="6" type="ORF">CELE_W01C9.5</name>
        <name evidence="8" type="ORF">W01C9.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAA90269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T26052">
        <property type="entry name" value="T26052"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_495806.1">
        <property type="nucleotide sequence ID" value="NM_063405.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q23117"/>
    <dbReference type="SMR" id="Q23117"/>
    <dbReference type="GeneID" id="189091"/>
    <dbReference type="UCSC" id="W01C9.5">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012178"/>
    <dbReference type="CTD" id="189091"/>
    <dbReference type="WormBase" id="W01C9.5a">
        <property type="protein sequence ID" value="CE02371"/>
        <property type="gene ID" value="WBGene00012178"/>
        <property type="gene designation" value="glb-27"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1373312_0_0_1"/>
    <dbReference type="OrthoDB" id="5859312at2759"/>
    <dbReference type="PhylomeDB" id="Q23117"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012178">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q23117">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF17">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="81"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA90269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="W01C9.5a"/>
        </source>
    </evidence>
    <sequence length="224" mass="25671" checksum="CF0001E8BE6AC340" modified="1996-11-01" version="1">MSGRDRSGSISLSPRNVIPVCSQLTPSQVSVVRRSWRHINTKGLIIVLTRCFSRLESNCPIVSQCFQSATYSLSTNPNGVRTVADHAKYLLQLLDKIIEGDVDSEFLREIGANHVCLKHESGFSTQEWDRFQEIMVEVILKQDGVKQSKETSRAWRLLICSFIELIRDGFDAQVRQFRRKHSFNAHVQYFENIEKRVGVCPSRKISLNVDPRTPPNGVRKYSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q23138</accession>
    <name>Q23138_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">dlgr-1</name>
        <name evidence="3" type="ORF">CELE_W03A5.6</name>
        <name evidence="5" type="ORF">W03A5.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F88456">
        <property type="entry name" value="F88456"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_498156.1">
        <property type="nucleotide sequence ID" value="NM_065755.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q23138"/>
    <dbReference type="SMR" id="Q23138"/>
    <dbReference type="PeptideAtlas" id="Q23138"/>
    <dbReference type="GeneID" id="189142"/>
    <dbReference type="UCSC" id="W03A5.4.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020970"/>
    <dbReference type="CTD" id="189142"/>
    <dbReference type="WormBase" id="W03A5.6c">
        <property type="protein sequence ID" value="CE01422"/>
        <property type="gene ID" value="WBGene00020970"/>
        <property type="gene designation" value="dlgr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_900898_0_0_1"/>
    <dbReference type="OMA" id="IEPHKFI"/>
    <dbReference type="OrthoDB" id="10036956at2759"/>
    <dbReference type="PhylomeDB" id="Q23138"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020970">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q23138">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF31">
        <property type="entry name" value="LD44824P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD73956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W03A5.6c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q23138"/>
        </source>
    </evidence>
    <sequence length="309" mass="34560" checksum="7EDE2C24DA912137" modified="1996-11-01" version="1">MGNHASIPQPIRDLISKFNQLDLCSAHKNEKEGIENIEPHKFIINQQPAFDEIDLKKDSNGNDDEKKDLKISIDAESDSGISGSSPASSKKNIDISKEEPKQDEEEEVTTTSTPSNGHEFQLLHDKVKAQLQTKMNAASTDLEHADDYPEKCSDSLRAAHGNAHLLVRKKFSKFNELIGKNLNPIADDPMPVTVQDLEGFWVTIDMELKGILKEFTKVEQYRAANWDPSAVKEEEEIDSTTNRPPIAPKTRPVTAKKKAPIVSEETRKKLAEQKALAEQRRAEMRAQILQNRKAAKNQEDPAIGASEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q2XMZ4</accession>
    <name>Q2XMZ4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lron-3</name>
        <name evidence="7" type="ORF">C02C6.3</name>
        <name evidence="5" type="ORF">CELE_C02C6.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAJ43438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359701.1">
        <property type="nucleotide sequence ID" value="NM_001373599.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2XMZ4"/>
    <dbReference type="SMR" id="Q2XMZ4"/>
    <dbReference type="PeptideAtlas" id="Q2XMZ4"/>
    <dbReference type="GeneID" id="181643"/>
    <dbReference type="UCSC" id="C02C6.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007261"/>
    <dbReference type="CTD" id="181643"/>
    <dbReference type="WormBase" id="C02C6.3b">
        <property type="protein sequence ID" value="CE39214"/>
        <property type="gene ID" value="WBGene00007261"/>
        <property type="gene designation" value="lron-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_750757_0_0_1"/>
    <dbReference type="OrthoDB" id="1574204at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007261">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2XMZ4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052286">
        <property type="entry name" value="Wnt_signaling_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24364">
        <property type="entry name" value="LP06937P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24364:SF18">
        <property type="entry name" value="LP06937P"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2XMZ9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22397">
        <property type="entry name" value="KH-I_FUBP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22398">
        <property type="entry name" value="KH-I_FUBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015096">
        <property type="entry name" value="FUBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09005">
        <property type="entry name" value="FUBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="90"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="184"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="275"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ43440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C12D8.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q2XMZ9"/>
        </source>
    </evidence>
    <sequence length="548" mass="58155" checksum="9AE053596539023A" modified="2005-12-20" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q65ZG6-2</accession>
    <name>KLF3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Kruppel-like factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">klf-3</name>
        <name evidence="4" type="ORF">F54H5.4</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2009" name="Exp. Cell Res." volume="315" first="2568" last="2580">
            <title>Mutation in Caenorhabditis elegans Krueppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition.</title>
            <authorList>
                <person name="Zhang J."/>
                <person name="Yang C."/>
                <person name="Brey C."/>
                <person name="Rodriguez M."/>
                <person name="Oksov Y."/>
                <person name="Gaugler R."/>
                <person name="Dickstein E."/>
                <person name="Huang C.H."/>
                <person name="Hashmi S."/>
            </authorList>
            <dbReference type="PubMed" id="19427851"/>
            <dbReference type="DOI" id="10.1016/j.yexcr.2009.04.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="J. Mol. Biol." volume="425" first="2641" last="2655">
            <title>Regulation of lipoprotein assembly, secretion and fatty acid beta-oxidation by Krueppel-like transcription factor, klf-3.</title>
            <authorList>
                <person name="Zhang J."/>
                <person name="Hashmi S."/>
                <person name="Cheema F."/>
                <person name="Al-Nasser N."/>
                <person name="Bakheet R."/>
                <person name="Parhar R.S."/>
                <person name="Al-Mohanna F."/>
                <person name="Gaugler R."/>
                <person name="Hussain M.M."/>
                <person name="Hashmi S."/>
            </authorList>
            <dbReference type="PubMed" id="23639358"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2013.04.020"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2017" name="Nutr. Metab." volume="14" first="22" last="22">
            <title>Defective lipid metabolism associated with mutation in klf-2 and klf-3: important roles of essential dietary salts in fat storage.</title>
            <authorList>
                <person name="Ling J."/>
                <person name="Brey C."/>
                <person name="Schilling M."/>
                <person name="Lateef F."/>
                <person name="Lopez-Dee Z.P."/>
                <person name="Fernandes K."/>
                <person name="Thiruchelvam K."/>
                <person name="Wang Y."/>
                <person name="Chandel K."/>
                <person name="Rau K."/>
                <person name="Parhar R."/>
                <person name="Al-Mohanna F."/>
                <person name="Gaugler R."/>
                <person name="Hashmi S."/>
            </authorList>
            <dbReference type="PubMed" id="28261316"/>
            <dbReference type="DOI" id="10.1186/s12986-017-0172-8"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q65ZG6-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061014"/>
        </isoform>
        <isoform>
            <id>Q65ZG6-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022204.1">
        <property type="nucleotide sequence ID" value="NM_001027033.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F54H5.4a">
        <property type="protein sequence ID" value="CE01967"/>
        <property type="gene ID" value="WBGene00003480"/>
        <property type="gene designation" value="klf-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F54H5.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F54H5.4b"/>
        </source>
    </evidence>
    <sequence length="309" mass="35131" checksum="AF466D1E81A640A7" modified="2004-10-11" version="1">MTSPNIFQDWADVYEFIERDSSRKNVPAIEAIERRLAFSPLITPNPGAKQFAPIHVPGREPPRMLLPPTPHFQAPFSPHPPPVQQVPSYSPPHAPPSYETYPEVYYPPHIICNPYDVPTTSDRNPPYYTEVTTVSAVTLHSMTPPTHKIETPPSSPENSFGPLASQLPAIKMEIPMHPLPHNGELDSTRSSPSSTTSSERSPLQRKSRIESNKRNPTDKKFVVHACTYPGCFKKYSKSSHLKAHERTHSGEKPFVCKWQNCSWKFARSDELTRHMRKHTGDKPFRCSLCDRNFARSDHLSLHMKRHSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-11" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q688A5</accession>
    <name>Q688A5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_E02H9.3</name>
        <name evidence="2 4" type="ORF">E02H9.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD68633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021234.1">
        <property type="nucleotide sequence ID" value="NM_001026063.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q688A5"/>
    <dbReference type="GeneID" id="175366"/>
    <dbReference type="KEGG" id="cel:CELE_E02H9.3"/>
    <dbReference type="UCSC" id="E02H9.3a.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017101"/>
    <dbReference type="CTD" id="175366"/>
    <dbReference type="WormBase" id="E02H9.3a">
        <property type="protein sequence ID" value="CE37218"/>
        <property type="gene ID" value="WBGene00017101"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_584272_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017101">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q688A5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004987">
        <property type="entry name" value="DUF272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21516">
        <property type="entry name" value="AAA_LID_7 DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21516:SF8">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03312">
        <property type="entry name" value="DUF272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD68633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="E02H9.3a"/>
        </source>
    </evidence>
    <sequence length="468" mass="52908" checksum="6E258EB196192266" modified="2004-10-11" version="1">MRAVRERITQRELNYDYLVPRADTQKRAEQEAADKRAATITVDSTMRAVRERITPRELNYDYLVPRADTQKHAEQEAADKRAATITVDSTMRAVRERITQRELNYDYLVPRADTQKHAEQEAADKRAATITVDSTMRAVRERITQRELVRKVENDTPKKSALIFDIRLNISREMIPEKIVHFEAVEIAPQAPNERFANPAQKVGSGFSTTAKKPEPIVGTGFSLASRTESPKPNSTVVGKRFQRPQTPKQNTKVVGSGFPSPQKQVTPANNNKVAGSGFPKPPKKEEKIVGTGFQPPKKDKNSEKQGQIVGEGFTTSQTKEEKQRAVVTRIDEKRPGLYYLWNLDSKTEGLFKTTKYVLALGHHFEGTFQKQEDGRCVCKEYIRQITELLHGGINDKEKLFLTVKITKFTPAGVNQKFSTGTAKYIGELLEGRTDETKLTAGCIGKTVKIERRRVGEKDYVWMVTKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-02-01" modified="2026-01-28" version="163" xmlns="https://uniprot.org/uniprot">
    <accession>Q93877</accession>
    <name>Q93877_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_K09E9.1</name>
        <name evidence="8 10" type="ORF">K09E9.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAB01888.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T23545">
        <property type="entry name" value="T23545"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q93877"/>
    <dbReference type="SMR" id="Q93877"/>
    <dbReference type="PaxDb" id="6239-K09E9.1.3"/>
    <dbReference type="UCSC" id="K09E9.1.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010724"/>
    <dbReference type="WormBase" id="K09E9.1a">
        <property type="protein sequence ID" value="CE31561"/>
        <property type="gene ID" value="WBGene00010724"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537742_0_0_1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="PhylomeDB" id="Q93877"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010724">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q93877">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB01888.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="K09E9.1a"/>
        </source>
    </evidence>
    <sequence length="508" mass="57124" checksum="95B88403F4535B9D" modified="2002-10-01" version="3">MKEEESIRLDVSSVSSDKVATEQRDDKGPLKLTEPRKRMREDFGYYEIRLLVLTQLGYIPVAAAMLMTAFMEPSPEWCDTVRETEQSWKLNPNNEFYSLSVERGFACQKNSNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFFCGGYMVTNFVILTEAFELPKSRLLVVSLNGWSVSMAVTALAASYTLNWYAYHTIFAIVGACIAIISLATCSESCRWLSANGLQNDAKKIALQITLLNNNRDIEEDDISILSWHEILGFSAPTHTDEKKTWKTLFKSTRFLKPTAVMCYSFMASSIVSFGFYFSIDVLPGNRYYNMTIMGILKFILGFTPFFLNRFLTKRAIAISSVGLCCLAALMILPIQYYDIQCMRWVIIMLSLMIAAGIDPTWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIVYLRTFGFFIPNAIFAVLLFIQLVVIVIFLPDDSDKDANEMNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-02-01" modified="2025-10-08" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q93892</accession>
    <name>Q93892_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_M02B1.3</name>
        <name evidence="8 10" type="ORF">M02B1.3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAB03202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T23674">
        <property type="entry name" value="T23674"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_502445.1">
        <property type="nucleotide sequence ID" value="NM_070044.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q93892"/>
    <dbReference type="PaxDb" id="6239-M02B1.3"/>
    <dbReference type="PeptideAtlas" id="Q93892"/>
    <dbReference type="GeneID" id="178236"/>
    <dbReference type="UCSC" id="M02B1.3.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010828"/>
    <dbReference type="CTD" id="178236"/>
    <dbReference type="WormBase" id="M02B1.3a">
        <property type="protein sequence ID" value="CE12316"/>
        <property type="gene ID" value="WBGene00010828"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056440_1_0_1"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="PhylomeDB" id="Q93892"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010828">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q93892">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF21">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="84"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB03202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="M02B1.3a"/>
        </source>
    </evidence>
    <sequence length="320" mass="36598" checksum="499924DD2FC0D41F" modified="1997-02-01" version="1">MAEALSRWQEGLNRIEAAPFHFFTLDNNSDVGVPSAVGAELEMPDYWGFVNSIFLPTVVFYTLLWFAVYACVQYNCWLSWQEGIKRKRLLNLTTSLIHSTISGLYLFAFFCYNTKLMFAAPLHYYTYLDSQIITLSIGYFFYDGIDLVMNDKLSISTGVLLFHHVASIYVLSTAVLSKKFLLYAYWAMLMEVSSIFLHTRSILHISKLSTTSMIGFSKVVSYLNLITFIVFRGFVQFFLFGWAWVNYDHIHFIFKCIAFGGGFCFAVINVSLLLRILHSDGFLLSSVVSQDRLDALLEDNEYSNSSESVAKSEKKELLDV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>Q94225-2</accession>
    <name>SULP3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Sulfate permease family protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sulp-3</name>
        <name type="ORF">F41D9.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Am. J. Physiol." volume="289" first="C341" last="C351">
            <title>The abts and sulp families of anion transporters from Caenorhabditis elegans.</title>
            <authorList>
                <person name="Sherman T."/>
                <person name="Chernova M.N."/>
                <person name="Clark J.S."/>
                <person name="Jiang L."/>
                <person name="Alper S.L."/>
                <person name="Nehrke K."/>
            </authorList>
            <dbReference type="PubMed" id="15814591"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00071.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94225-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q94225-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_019780"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="762" mass="85509" checksum="CA563FE521A66EA4" modified="2006-07-11" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q95Q17-2</accession>
    <name>MED7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>CeMED7</fullName>
            <shortName>MED-7</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Lethal protein 49</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Mediator complex subunit 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">let-49</name>
        <name type="synonym">mdt-7</name>
        <name type="synonym">med-7</name>
        <name type="ORF">Y54E5B.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1999" name="Proc. Natl. Acad. Sci. U.S.A." volume="96" first="14990" last="14995">
            <title>Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation.</title>
            <authorList>
                <person name="Kwon J.Y."/>
                <person name="Park J.M."/>
                <person name="Gim B.S."/>
                <person name="Han S.J."/>
                <person name="Lee J."/>
                <person name="Kim Y.-J."/>
            </authorList>
            <dbReference type="PubMed" id="10611325"/>
            <dbReference type="DOI" id="10.1073/pnas.96.26.14990"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MDT-10; MDT-21 AND RNA POLYMERASE II</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="FEBS Lett." volume="508" first="305" last="308">
            <title>The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kwon J.Y."/>
                <person name="Kim-Ha J."/>
                <person name="Lee B.J."/>
                <person name="Lee J."/>
            </authorList>
            <dbReference type="PubMed" id="11728440"/>
            <dbReference type="DOI" id="10.1016/S0014-5793(01)03072-1"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95Q17-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95Q17-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_028004"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_493585.1">
        <property type="nucleotide sequence ID" value="NM_061184.6"/>
    </dbReference>
    <dbReference type="WormBase" id="Y54E5B.3a">
        <property type="protein sequence ID" value="CE19227"/>
        <property type="gene ID" value="WBGene00002324"/>
        <property type="gene designation" value="let-49"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="253" mass="29090" checksum="78B3998585929E13" modified="2001-12-01" version="1">MLPGFGAQTVSPFPNPPEYASAYTSDRINNDSGSAPPPPHPLTEFKVYGEEYRLEDDVIAPLKNAGVAELYKNKNNWKTEMKKLNRSAIVAFFDLVEILIRAPDHPMREEKMVDLHTIFINMHHLINEFRPVQARDSVRILQERQIEELSDICKDFKKYLRDGREVVDDQFQMIRGKLPAPPQPSELTRVKLQDGVLHMLQETEASDDVEMKEEEGSEYSKKKARLELLSREDGPPSVVHLLARQFHDISLKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-12-11" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>Q95XN2-2</accession>
    <name>MPPA_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Inactive zinc metalloprotease mppa-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">mppa-1</name>
        <name evidence="3" type="ORF">Y71G12B.24</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2006" name="J. Biochem." volume="139" first="967" last="979">
            <title>Identification and reverse genetic analysis of mitochondrial processing peptidase and the core protein of the cytochrome bc1 complex of Caenorhabditis elegans, a model parasitic nematode.</title>
            <authorList>
                <person name="Nomura H."/>
                <person name="Athauda S.B.P."/>
                <person name="Wada H."/>
                <person name="Maruyama Y."/>
                <person name="Takahashi K."/>
                <person name="Inoue H."/>
            </authorList>
            <dbReference type="PubMed" id="16788047"/>
            <dbReference type="DOI" id="10.1093/jb/mvj114"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>LACK OF PROTEASE ACTIVITY</scope>
        <scope>IDENTIFICATION IN COMPLEX WITH MPPB-1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95XN2-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95XN2-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_060435"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001380168.1">
        <property type="nucleotide sequence ID" value="NM_001392974.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y71G12B.24b">
        <property type="protein sequence ID" value="CE49612"/>
        <property type="gene ID" value="WBGene00022159"/>
        <property type="gene designation" value="mppa-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="16788047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="CCD67978.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y71G12B.24a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y71G12B.24b"/>
        </source>
    </evidence>
    <sequence length="162" mass="18686" checksum="D69213DA0368B4E0" modified="2013-04-03" version="2" precursor="true">MYARMYTELMNRHHWIYSAIAHNHSYSDSGVFTVTASSPPENINDALILLVHQILQLQQGVEPTELARARTQLRSHLMMNLEVRPVLFEDMVRQVLGHGDRKQPEEYAEKIEKVTNSDIIRVTERLLASKPSLVGYGDIKKLKDLRSLDQAVAKRDLKYLFN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q95XZ5-2</accession>
    <name>NIPBL_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Nipped-B-like protein scc-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Prion-like-(Q/N-rich) domain-bearing protein 85</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>SCC2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">scc-2</name>
        <name evidence="3" type="synonym">pqn-85</name>
        <name evidence="3" type="ORF">Y43H11AL.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nat. Genet." volume="36" first="636" last="641">
            <title>NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome.</title>
            <authorList>
                <person name="Tonkin E.T."/>
                <person name="Wang T.-J."/>
                <person name="Lisgo S."/>
                <person name="Bamshad M.J."/>
                <person name="Strachan T."/>
            </authorList>
            <dbReference type="PubMed" id="15146185"/>
            <dbReference type="DOI" id="10.1038/ng1363"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="PLoS Biol." volume="4" first="E242" last="E242">
            <title>Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.</title>
            <authorList>
                <person name="Seitan V.C."/>
                <person name="Banks P."/>
                <person name="Laval S."/>
                <person name="Majid N.A."/>
                <person name="Dorsett D."/>
                <person name="Rana A."/>
                <person name="Smith J."/>
                <person name="Bateman A."/>
                <person name="Krpic S."/>
                <person name="Hostert A."/>
                <person name="Rollins R.A."/>
                <person name="Erdjument-Bromage H."/>
                <person name="Tempst P."/>
                <person name="Benard C.Y."/>
                <person name="Hekimi S."/>
                <person name="Newbury S.F."/>
                <person name="Strachan T."/>
            </authorList>
            <dbReference type="PubMed" id="16802858"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.0040242"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Curr. Biol." volume="21" first="1421" last="1430">
            <title>Loading of meiotic cohesin by SCC-2 is required for early processing of DSBs and for the DNA damage checkpoint.</title>
            <authorList>
                <person name="Lightfoot J."/>
                <person name="Testori S."/>
                <person name="Barroso C."/>
                <person name="Martinez-Perez E."/>
            </authorList>
            <dbReference type="PubMed" id="21856158"/>
            <dbReference type="DOI" id="10.1016/j.cub.2011.07.007"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF HIS-112</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95XZ5-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95XZ5-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_061056"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001300604.1">
        <property type="nucleotide sequence ID" value="NM_001313675.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y43H11AL.3b">
        <property type="protein sequence ID" value="CE50846"/>
        <property type="gene ID" value="WBGene00004166"/>
        <property type="gene designation" value="scc-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="21856158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y43H11AL.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y43H11AL.3b"/>
        </source>
    </evidence>
    <sequence length="415" mass="48010" checksum="A500C440931121DE" modified="2021-06-02" version="3">MFLQCEEQKLAASHDKWDENKEAQNLKEMELSGSGLGSSVIQKYWKAVLESYVDADIQLRRAAVQVVWLTLNQGLVTPGASIPTLIAMTTDPVDVIRNRIDILLKEIDSKYSGMVQSKAMQGVRLSYKLHLKLRMLQQEKFVRGFRFCDFHLNTLPNALPEKTHDGMAVLSGLYQSLRTNRQQRRSFLQSMVKLFSEEFSHDKPQLMEYIFIADNLAMFPYQMIDEPLYVMRQIDQNIAQTGQSLLVQYKLQLRMQESEDEDIVFLDENMMSRLSQLGQIETFHQLFLDSQVPSLLLYVRTFLMQLYGFNETKVAEYQPSEAAKVYEKAVTRRNIHMFKPITALEALNFPFEWGSFQHTAFLAEKICSFRKMLLSLDQVEEVEVSNTITAANDDYDEEEDGGEDSRGPIMEQMEH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>Q9BL19-2</accession>
    <name>RL17_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rpl-17</name>
        <name type="ORF">Y48G8AL.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9BL19-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_032019"/>
        </isoform>
        <isoform>
            <id>Q9BL19-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="159" mass="18419" checksum="EB6852B9D8A6BFD8" modified="2001-06-01" version="1">MTKVHYSRAPENSTKSCKARGSDLRVHFKNTHEAAMALRGMPLRRAQAFLNHVKEHKEIVPFRRFLDLLKNAESNAEYKGLDVDHLVIEHINVQRAAKLRRRTYRAHGRINPYMSSPCHIEVILAEKEDVVSKPTDDAAPKVKKESKRKQRRQLARGEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-08-10" modified="2026-01-28" version="170" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N3Q4-2</accession>
    <name>ATM_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Serine/threonine-protein kinase ATM</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">atm-1</name>
        <name type="ORF">Y48G1BL.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2006" name="Curr. Biol." volume="16" first="1344" last="1350">
            <title>Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi.</title>
            <authorList>
                <person name="van Haaften G."/>
                <person name="Romeijn R."/>
                <person name="Pothof J."/>
                <person name="Koole W."/>
                <person name="Mullenders L.H."/>
                <person name="Pastink A."/>
                <person name="Plasterk R.H."/>
                <person name="Tijsterman M."/>
            </authorList>
            <dbReference type="PubMed" id="16824923"/>
            <dbReference type="DOI" id="10.1016/j.cub.2006.05.047"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2007" name="Cell Death Differ." volume="14" first="1129" last="1138">
            <title>The nucleotide excision repair pathway is required for UV-C-induced apoptosis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Stergiou L."/>
                <person name="Doukoumetzidis K."/>
                <person name="Sendoel A."/>
                <person name="Hengartner M.O."/>
            </authorList>
            <dbReference type="PubMed" id="17347667"/>
            <dbReference type="DOI" id="10.1038/sj.cdd.4402115"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Mol. Genet. Genomics" volume="287" first="325" last="335">
            <title>The atm-1 gene is required for genome stability in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Jones M.R."/>
                <person name="Huang J.C."/>
                <person name="Chua S.Y."/>
                <person name="Baillie D.L."/>
                <person name="Rose A.M."/>
            </authorList>
            <dbReference type="PubMed" id="22350747"/>
            <dbReference type="DOI" id="10.1007/s00438-012-0681-0"/>
        </citation>
        <scope>REVISION OF GENE MODEL</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9N3Q4-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9N3Q4-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_055333"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="RefSeq" id="NP_001293215.1">
        <property type="nucleotide sequence ID" value="NM_001306286.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y48G1BL.2b">
        <property type="protein sequence ID" value="CE49311"/>
        <property type="gene ID" value="WBGene00000227"/>
        <property type="gene designation" value="atm-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q13315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1701" mass="196422" checksum="E90CE71BD649A678" modified="2014-07-09" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2025-10-08" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TYW4</accession>
    <name>Q9TYW4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">fln-1</name>
        <name evidence="7" type="ORF">CELE_Y66H1B.2</name>
        <name evidence="9" type="ORF">Y66H1B.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD69678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T33759">
        <property type="entry name" value="T33759"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023551.2">
        <property type="nucleotide sequence ID" value="NM_001028380.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9TYW4"/>
    <dbReference type="SMR" id="Q9TYW4"/>
    <dbReference type="PeptideAtlas" id="Q9TYW4"/>
    <dbReference type="GeneID" id="176855"/>
    <dbReference type="UCSC" id="Y66H1B.3.1">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00022048"/>
    <dbReference type="CTD" id="176855"/>
    <dbReference type="WormBase" id="Y66H1B.2b">
        <property type="protein sequence ID" value="CE20347"/>
        <property type="gene ID" value="WBGene00022048"/>
        <property type="gene designation" value="fln-1"/>
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    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="PhylomeDB" id="Q9TYW4"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <dbReference type="Bgee" id="WBGene00022048">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9TYW4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
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    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
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    <dbReference type="GO" id="GO:0061038">
        <property type="term" value="P:uterus morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
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    <dbReference type="CDD" id="cd21311">
        <property type="entry name" value="CH_dFLNA-like_rpt1"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd21230">
        <property type="entry name" value="CH_FLN_rpt2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.418.10:FF:000006">
        <property type="entry name" value="Filamin-B isoform A"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.418.10:FF:000008">
        <property type="entry name" value="Filamin-B isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000001">
        <property type="entry name" value="Filamin-C isoform b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="CH_dom"/>
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    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
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    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
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    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
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    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="5"/>
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    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="150"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="252"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="367"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="541"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="636"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="733"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="827"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="954"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="916"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1058"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1063"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD69678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y66H1B.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q9TYW4"/>
        </source>
    </evidence>
    <sequence length="1084" mass="118625" checksum="29833A026AFC7078" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2025-10-08" version="165" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TYY8</accession>
    <name>Q9TYY8_CAEEL</name>
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        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">usp-4</name>
        <name evidence="11" type="ORF">CELE_H34C03.2</name>
        <name evidence="13" type="ORF">H34C03.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCD65007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T33734">
        <property type="entry name" value="T33734"/>
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    <dbReference type="RefSeq" id="NP_501035.1">
        <property type="nucleotide sequence ID" value="NM_068634.8"/>
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    <dbReference type="MEROPS" id="C19.A33"/>
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    <dbReference type="UCSC" id="H34C03.2">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="CTD" id="177437"/>
    <dbReference type="WormBase" id="H34C03.2a">
        <property type="protein sequence ID" value="CE19500"/>
        <property type="gene ID" value="WBGene00019259"/>
        <property type="gene designation" value="usp-4"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001060_8_2_1"/>
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    <dbReference type="PhylomeDB" id="Q9TYY8"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019259">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9TYY8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DUSP-like_sf"/>
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    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="Pept_C19_DUSP"/>
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        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
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    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="275"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="851"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="873"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD65007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="H34C03.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q9TYY8"/>
        </source>
    </evidence>
    <sequence length="900" mass="102646" checksum="42A0A55A2E40D6E9" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="188" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XTY1-2</accession>
    <name>GCY22_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Receptor-type guanylate cyclase gcy-22</fullName>
            <ecNumber evidence="1">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gcy-22</name>
        <name evidence="4" type="ORF">T03D8.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2005" name="Proc. Natl. Acad. Sci. U.S.A." volume="102" first="12449" last="12454">
            <title>MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision.</title>
            <authorList>
                <person name="Johnston R.J. Jr."/>
                <person name="Chang S."/>
                <person name="Etchberger J.F."/>
                <person name="Ortiz C.O."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="16099833"/>
            <dbReference type="DOI" id="10.1073/pnas.0505530102"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2009" name="Curr. Biol." volume="19" first="996" last="1004">
            <title>Lateralized gustatory behavior of C. elegans is controlled by specific receptor-type guanylyl cyclases.</title>
            <authorList>
                <person name="Ortiz C.O."/>
                <person name="Faumont S."/>
                <person name="Takayama J."/>
                <person name="Ahmed H.K."/>
                <person name="Goldsmith A.D."/>
                <person name="Pocock R."/>
                <person name="McCormick K.E."/>
                <person name="Kunimoto H."/>
                <person name="Iino Y."/>
                <person name="Lockery S."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="19523832"/>
            <dbReference type="DOI" id="10.1016/j.cub.2009.05.043"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2010" name="Genetics" volume="186" first="1309" last="1319">
            <title>Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Adachi T."/>
                <person name="Kunitomo H."/>
                <person name="Tomioka M."/>
                <person name="Ohno H."/>
                <person name="Okochi Y."/>
                <person name="Mori I."/>
                <person name="Iino Y."/>
            </authorList>
            <dbReference type="PubMed" id="20837997"/>
            <dbReference type="DOI" id="10.1534/genetics.110.119768"/>
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        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-596; MET-710 AND GLU-912</scope>
    </reference>
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            <id>Q9XTY1-2</id>
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    <evidence type="ECO:0000312" key="3">
        <source>
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    <evidence type="ECO:0000312" key="4">
        <source>
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        <source>
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    </evidence>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2005" name="Proc. Natl. Acad. Sci. U.S.A." volume="102" first="12449" last="12454">
            <title>MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision.</title>
            <authorList>
                <person name="Johnston R.J. Jr."/>
                <person name="Chang S."/>
                <person name="Etchberger J.F."/>
                <person name="Ortiz C.O."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="16099833"/>
            <dbReference type="DOI" id="10.1073/pnas.0505530102"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2009" name="Curr. Biol." volume="19" first="996" last="1004">
            <title>Lateralized gustatory behavior of C. elegans is controlled by specific receptor-type guanylyl cyclases.</title>
            <authorList>
                <person name="Ortiz C.O."/>
                <person name="Faumont S."/>
                <person name="Takayama J."/>
                <person name="Ahmed H.K."/>
                <person name="Goldsmith A.D."/>
                <person name="Pocock R."/>
                <person name="McCormick K.E."/>
                <person name="Kunimoto H."/>
                <person name="Iino Y."/>
                <person name="Lockery S."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="19523832"/>
            <dbReference type="DOI" id="10.1016/j.cub.2009.05.043"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2010" name="Genetics" volume="186" first="1309" last="1319">
            <title>Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Adachi T."/>
                <person name="Kunitomo H."/>
                <person name="Tomioka M."/>
                <person name="Ohno H."/>
                <person name="Okochi Y."/>
                <person name="Mori I."/>
                <person name="Iino Y."/>
            </authorList>
            <dbReference type="PubMed" id="20837997"/>
            <dbReference type="DOI" id="10.1534/genetics.110.119768"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-596; MET-710 AND GLU-912</scope>
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        <source>
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        <source>
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    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T03D8.5a"/>
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        <source>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
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    <dbReference type="EMBL" id="BX284603">
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        <property type="entry name" value="T26310"/>
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    <dbReference type="HOGENOM" id="CLU_010423_0_0_1"/>
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        <property type="component" value="Chromosome III"/>
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    <dbReference type="Bgee" id="WBGene00012356">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XUJ4">
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        <property type="entry name" value="AMP-bd_C_sf"/>
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            <begin position="533"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13360"/>
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        <source>
            <dbReference type="EMBL" id="CAB04944.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W09D6.1a"/>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2001" name="J. Mol. Biol." volume="314" first="1017" last="1028">
            <title>DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs.</title>
            <authorList>
                <person name="Yu H."/>
                <person name="Larsen P.L."/>
            </authorList>
            <dbReference type="PubMed" id="11743719"/>
            <dbReference type="DOI" id="10.1006/jmbi.2000.5210"/>
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        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2010" name="PLoS ONE" volume="5" first="E10161" last="E10161">
            <title>A monoclonal antibody toolkit for C. elegans.</title>
            <authorList>
                <person name="Hadwiger G."/>
                <person name="Dour S."/>
                <person name="Arur S."/>
                <person name="Fox P."/>
                <person name="Nonet M.L."/>
            </authorList>
            <dbReference type="PubMed" id="20405020"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0010161"/>
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        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E40290" last="E40290">
            <title>Nucleologenesis in the Caenorhabditis elegans embryo.</title>
            <authorList>
                <person name="Korcekova D."/>
                <person name="Gombitova A."/>
                <person name="Raska I."/>
                <person name="Cmarko D."/>
                <person name="Lanctot C."/>
            </authorList>
            <dbReference type="PubMed" id="22768349"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0040290"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2014" name="Cell Death Dis." volume="5" first="E1158" last="E1158">
            <title>Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans.</title>
            <authorList>
                <person name="Lee C.C."/>
                <person name="Tsai Y.T."/>
                <person name="Kao C.W."/>
                <person name="Lee L.W."/>
                <person name="Lai H.J."/>
                <person name="Ma T.H."/>
                <person name="Chang Y.S."/>
                <person name="Yeh N.H."/>
                <person name="Lo S.J."/>
            </authorList>
            <dbReference type="PubMed" id="24722283"/>
            <dbReference type="DOI" id="10.1038/cddis.2014.114"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH RNA POLYMERASE I</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="3" key="6">
        <citation type="journal article" date="2016" name="Nucleus" volume="7" first="112" last="120">
            <title>Genetic control of nucleolar size: An evolutionary perspective.</title>
            <authorList>
                <person name="Ma T.H."/>
                <person name="Lee L.W."/>
                <person name="Lee C.C."/>
                <person name="Yi Y.H."/>
                <person name="Chan S.P."/>
                <person name="Tan B.C."/>
                <person name="Lo S.J."/>
            </authorList>
            <dbReference type="PubMed" id="27003693"/>
            <dbReference type="DOI" id="10.1080/19491034.2016.1166322"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9XVS4-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9XVS4-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_059730"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021005.1">
        <property type="nucleotide sequence ID" value="NM_001025834.6"/>
    </dbReference>
    <dbReference type="WormBase" id="C25A1.10b">
        <property type="protein sequence ID" value="CE38279"/>
        <property type="gene ID" value="WBGene00000931"/>
        <property type="gene designation" value="dao-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q14978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="11743719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C25A1.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C25A1.10b"/>
        </source>
    </evidence>
    <sequence length="696" mass="73396" checksum="223CA1AA5EB87540" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>S6FWP2</accession>
    <name>S6FWP2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">zip-1</name>
        <name evidence="2" type="ORF">CELE_Y75B8A.35</name>
        <name evidence="4" type="ORF">Y75B8A.35</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDG24105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293607.1">
        <property type="nucleotide sequence ID" value="NM_001306678.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6FWP2"/>
    <dbReference type="SMR" id="S6FWP2"/>
    <dbReference type="GeneID" id="176656"/>
    <dbReference type="KEGG" id="cel:CELE_Y75B8A.35"/>
    <dbReference type="AGR" id="WB:WBGene00006986"/>
    <dbReference type="CTD" id="176656"/>
    <dbReference type="WormBase" id="Y75B8A.35c">
        <property type="protein sequence ID" value="CE48493"/>
        <property type="gene ID" value="WBGene00006986"/>
        <property type="gene designation" value="zip-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590854_0_0_1"/>
    <dbReference type="OrthoDB" id="5874429at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006986">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6FWP2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDG24105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y75B8A.35c"/>
        </source>
    </evidence>
    <sequence length="167" mass="19151" checksum="B29BB198976E53F6" modified="2013-10-16" version="1">MLREKVQEAKRQNEMQENGLLAAYETNIFAVQGNNFPYGSLELFYDQLQGSKAEAVEQVQYDNNGEVVQLEEAFNKTEQDYGQYTSVKKIAGLPQNTFASKKSRAKTAFEIADHQLNLKKEEVELREANAIKVVLNQITRELNRYMDGAKLAEQQAFDENFQQFEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>S6FWP9</accession>
    <name>S6FWP9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine 3-monooxygenase</fullName>
            <ecNumber evidence="5">1.14.16.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Tyrosine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">cat-2</name>
        <name evidence="20" type="ORF">B0432.5</name>
        <name evidence="18" type="ORF">CELE_B0432.5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.2" evidence="5"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDG24121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370901.1">
        <property type="nucleotide sequence ID" value="NM_001383774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6FWP9"/>
    <dbReference type="SMR" id="S6FWP9"/>
    <dbReference type="GeneID" id="173411"/>
    <dbReference type="AGR" id="WB:WBGene00000296"/>
    <dbReference type="CTD" id="173411"/>
    <dbReference type="WormBase" id="B0432.5b">
        <property type="protein sequence ID" value="CE37742"/>
        <property type="gene ID" value="WBGene00000296"/>
        <property type="gene designation" value="cat-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023198_0_1_1"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="PhylomeDB" id="S6FWP9"/>
    <dbReference type="UniPathway" id="UPA00747">
        <property type="reaction ID" value="UER00733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000296">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6FWP9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004511">
        <property type="term" value="F:tyrosine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042416">
        <property type="term" value="P:dopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03345">
        <property type="entry name" value="eu_TyrOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000004">
        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041903">
        <property type="entry name" value="Eu_TyrOH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF15">
        <property type="entry name" value="TYROSINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0127">Catecholamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 15" id="KW-0408">Iron</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="17">
        <location>
            <begin position="103"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDG24121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="B0432.5b"/>
        </source>
    </evidence>
    <sequence length="454" mass="51313" checksum="1AC61E1D39DBB283" modified="2013-10-16" version="1">MRCQKILQQLNDEGIEVIFTANDVTPIEFSIILTSTDPTLSNFVSDILQNMSSAKVQICHVETRGNEASHDVLLACKATKNQLIHSAELLTQNHVALTKFSIFAKKLSDEKNQSQIWFPRHISELDQCSKCITKYEPTTDPRHPGHGDVAYIARRKFLNDQALEFKFGDEIGYVDYTEEEHATWKAVYEKLGDLHLSHTCAVYRQNLKILQEEKVLTADRIPQIRDVNKFLQKKTGFELRPCSGLLSARDFLASLAFRVFQTTTYLRHHKSPHHSPEPDLIHELLGHVPMFSDPLLAQMSQDIGLMSLGASDEHIEKLSTVYWFIVEFGLCKEDGKLKAIGAGLLSAYGELMHACSDAPEHKDFDPAVTAVQKYEDDDYQPLYFVADSIHDALAKLRKYASSMDRPFSVVYDPFTKSIEAIESSADLEKAFSRLSNDLSAITHAADRMKISITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>S6FWQ9</accession>
    <name>S6FWQ9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y43E12A.3</name>
        <name evidence="2 4" type="ORF">Y43E12A.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDG24151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293860.1">
        <property type="nucleotide sequence ID" value="NM_001306931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6FWQ9"/>
    <dbReference type="GeneID" id="177995"/>
    <dbReference type="AGR" id="WB:WBGene00012795"/>
    <dbReference type="CTD" id="177995"/>
    <dbReference type="WormBase" id="Y43E12A.3c">
        <property type="protein sequence ID" value="CE48422"/>
        <property type="gene ID" value="WBGene00012795"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_886320_0_0_1"/>
    <dbReference type="OrthoDB" id="5779840at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012795">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6FWQ9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="137"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDG24151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y43E12A.3c"/>
        </source>
    </evidence>
    <sequence length="301" mass="34714" checksum="1ADEEED4602470C1" modified="2013-10-16" version="1">MVEAPGTFVEVNDTRVIIGKGLSLDSIKFPDFHMFDTNWKMKLHAEWSEELGTDVVSIKLRHRRRNVDDIWSMDATVKIHFEQDWLKGEIPNCGTVVGKLNSSEIHLCVHIFMQINQSKGIQLRNYIDFARPIPIFSDTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDERSLELCNISAPDFRRILNIIYPPHLPPKQWIKESDLVEQFEHIQRILRIGKSLQISIVLEVADKWLVKYGRHKLGDTLHLAQAFGLRELMGSKLAKMRSLEEIKKCQDQIQVLSCKTKALILDRILSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLK2</accession>
    <name>V6CLK2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">znf-236</name>
        <name evidence="9" type="ORF">CELE_Y48G8AL.10</name>
        <name evidence="11" type="ORF">Y48G8AL.10</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293228.1">
        <property type="nucleotide sequence ID" value="NM_001306299.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLK2"/>
    <dbReference type="GeneID" id="3565634"/>
    <dbReference type="AGR" id="WB:WBGene00021689"/>
    <dbReference type="CTD" id="3565634"/>
    <dbReference type="WormBase" id="Y48G8AL.10d">
        <property type="protein sequence ID" value="CE49168"/>
        <property type="gene ID" value="WBGene00021689"/>
        <property type="gene designation" value="znf-236"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007369_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021689">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLK2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003272">
        <property type="entry name" value="gastrula zinc finger protein XlCGF67.1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002539">
        <property type="entry name" value="GD10244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDK13489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y48G8AL.10d"/>
        </source>
    </evidence>
    <sequence length="570" mass="64412" checksum="2788B6C3007C0ED9" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLK7</accession>
    <name>V6CLK7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y4C6B.3</name>
        <name evidence="4 6" type="ORF">Y4C6B.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLK7"/>
    <dbReference type="SMR" id="V6CLK7"/>
    <dbReference type="AGR" id="WB:WBGene00021157"/>
    <dbReference type="WormBase" id="Y4C6B.3b">
        <property type="protein sequence ID" value="CE49391"/>
        <property type="gene ID" value="WBGene00021157"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_3_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021157">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLK7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDK13494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y4C6B.3b"/>
        </source>
    </evidence>
    <sequence length="405" mass="45167" checksum="21D7AD22456C79E7" modified="2014-02-19" version="1">MYDYTPTEKKHILWAVSFGTIVGIFPINMLYVQCGARLAFFSAGLLSAMTTAFTPWAASQSMWFLVALRFLQGVAYSADFAAIGIIISKWAPLDETAVFIATLTSFTAISSIITNGVSGVICESHLGWRWSFYLHAAACLIVFLTWGLVYKNDPSLHKSVSAKELGKIQKNKSDAHMKDSMQIPYRKIFTSPVVITVWLCAFTELSTLILIATYAPIYFRNVLKFDIKMIGFYLGLILAIHLPFRFVCALLSDKTRCISEMSKIHIFNTLSVGFVGISFIAFGQIPHEHNLSAVICLGVLECFTSFSSGGFYKCGTLHARQFSSIVISAIQFTKCIALFSGPALVAFFVTDESNQTQWSHVFMTLAGFTFFANILSYIYFTDQPAEWTEEKNPVKYSKNGDIIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLM0</accession>
    <name>V6CLM0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">sfrp-1</name>
        <name evidence="1" type="ORF">CELE_Y73B6BL.21</name>
        <name evidence="3" type="ORF">Y73B6BL.21</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368402.1">
        <property type="nucleotide sequence ID" value="NM_001380275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLM0"/>
    <dbReference type="SMR" id="V6CLM0"/>
    <dbReference type="GeneID" id="177401"/>
    <dbReference type="AGR" id="WB:WBGene00022242"/>
    <dbReference type="CTD" id="177401"/>
    <dbReference type="WormBase" id="Y73B6BL.21c">
        <property type="protein sequence ID" value="CE49273"/>
        <property type="gene ID" value="WBGene00022242"/>
        <property type="gene designation" value="sfrp-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054647_2_0_1"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022242">
        <property type="expression patterns" value="Expressed in embryo and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLM0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y73B6BL.21c"/>
        </source>
    </evidence>
    <sequence length="67" mass="8225" checksum="1CCF2B653EEF4741" modified="2014-02-19" version="1">MASRQPDGKYLANLVLPWQKEKNFKRAIHQFQRLNCQSLGREIRESASRRPHYYEMRRHNTGRYQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLM1</accession>
    <name>V6CLM1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F41H10.3</name>
        <name evidence="2 4" type="ORF">F41H10.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLM1"/>
    <dbReference type="SMR" id="V6CLM1"/>
    <dbReference type="PeptideAtlas" id="V6CLM1"/>
    <dbReference type="AGR" id="WB:WBGene00018316"/>
    <dbReference type="WormBase" id="F41H10.3d">
        <property type="protein sequence ID" value="CE49190"/>
        <property type="gene ID" value="WBGene00018316"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874112at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018316">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLM1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F41H10.3d"/>
        </source>
    </evidence>
    <sequence length="778" mass="86334" checksum="11DD107E1E4D12C5" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLM3</accession>
    <name>V6CLM3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crossover junction endonuclease MUS81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">eme-1</name>
        <name evidence="1" type="ORF">CELE_F56A6.4</name>
        <name evidence="3" type="ORF">F56A6.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293209.1">
        <property type="nucleotide sequence ID" value="NM_001306280.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLM3"/>
    <dbReference type="SMR" id="V6CLM3"/>
    <dbReference type="GeneID" id="171652"/>
    <dbReference type="KEGG" id="cel:CELE_F56A6.4"/>
    <dbReference type="AGR" id="WB:WBGene00018923"/>
    <dbReference type="CTD" id="171652"/>
    <dbReference type="WormBase" id="F56A6.4b">
        <property type="protein sequence ID" value="CE28462"/>
        <property type="gene ID" value="WBGene00018923"/>
        <property type="gene designation" value="eme-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1511955_0_0_1"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018923">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLM3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F56A6.4b"/>
        </source>
    </evidence>
    <sequence length="178" mass="19476" checksum="81246F88310BE583" modified="2014-02-19" version="1">MLIVSFGRAEIAKKKKLHNLSLQIYEQHRAQIVQIETIAELALFTAQYLRSLARQEKKKLDAGSDGGGGGGAGGAGGHKLQYQGDKGIVIGSRSEIVTDWWSKMLTTIDRLSDAQRRAILELIPDPIAAIDKYSKMDYSLAIQEIGELVAENGRRVGPSMAHRILTMLTDETGNSVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLM5</accession>
    <name>V6CLM5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Neuropeptide-Like Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">nlp-71</name>
        <name evidence="1" type="ORF">CELE_Y73B6BL.35</name>
        <name evidence="3" type="ORF">Y73B6BL.35</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368406.1">
        <property type="nucleotide sequence ID" value="NM_001380276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLM5"/>
    <dbReference type="GeneID" id="177402"/>
    <dbReference type="KEGG" id="cel:CELE_Y73B6BL.35"/>
    <dbReference type="AGR" id="WB:WBGene00022254"/>
    <dbReference type="CTD" id="177402"/>
    <dbReference type="WormBase" id="Y73B6BL.35b">
        <property type="protein sequence ID" value="CE49200"/>
        <property type="gene ID" value="WBGene00022254"/>
        <property type="gene designation" value="nlp-71"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2485415_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022254">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLM5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y73B6BL.35b"/>
        </source>
    </evidence>
    <sequence length="40" mass="5055" checksum="8E42F240D6615669" modified="2014-02-19" version="1">MLRPNRYWKRAHNIDTRALNQFKNCYFSPIQCVLMERRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLM8</accession>
    <name>V6CLM8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP_EFTU_D2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nabp-1</name>
        <name evidence="4" type="ORF">C06G3.8</name>
        <name evidence="2" type="ORF">CELE_C06G3.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368394.1">
        <property type="nucleotide sequence ID" value="NM_001380301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLM8"/>
    <dbReference type="SMR" id="V6CLM8"/>
    <dbReference type="PeptideAtlas" id="V6CLM8"/>
    <dbReference type="GeneID" id="177470"/>
    <dbReference type="KEGG" id="cel:CELE_C06G3.8"/>
    <dbReference type="AGR" id="WB:WBGene00015554"/>
    <dbReference type="CTD" id="177470"/>
    <dbReference type="WormBase" id="C06G3.8b">
        <property type="protein sequence ID" value="CE49416"/>
        <property type="gene ID" value="WBGene00015554"/>
        <property type="gene designation" value="nabp-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102724_3_1_1"/>
    <dbReference type="OrthoDB" id="295715at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015554">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLM8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:001000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C06G3.8b"/>
        </source>
    </evidence>
    <sequence length="84" mass="9372" checksum="EE2211CED153C7A2" modified="2014-02-19" version="1">MNPEFNETFKPGDILKFRGAYTSIYQGGLTLSVGKSGECKKVGEFMMVFSETPDISMMPLPAGVMDRRNERMQSPAGRYSRPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLN0</accession>
    <name>V6CLN0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LIN-24 (Twenty-four) Like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">lntl-1</name>
        <name evidence="3" type="ORF">C31H1.6</name>
        <name evidence="1" type="ORF">CELE_C31H1.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368410.1">
        <property type="nucleotide sequence ID" value="NM_001380242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLN0"/>
    <dbReference type="SMR" id="V6CLN0"/>
    <dbReference type="PeptideAtlas" id="V6CLN0"/>
    <dbReference type="GeneID" id="183098"/>
    <dbReference type="AGR" id="WB:WBGene00016289"/>
    <dbReference type="CTD" id="183098"/>
    <dbReference type="WormBase" id="C31H1.6c">
        <property type="protein sequence ID" value="CE49172"/>
        <property type="gene ID" value="WBGene00016289"/>
        <property type="gene designation" value="lntl-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064578_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016289">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLN0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39369">
        <property type="entry name" value="LIN-24 (TWENTY-FOUR) LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39369:SF6">
        <property type="entry name" value="LIN-24 (TWENTY-FOUR) LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C31H1.6c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLN0"/>
        </source>
    </evidence>
    <sequence length="129" mass="14569" checksum="37CD135CDB99E991" modified="2014-02-19" version="1">MLNHIGENTSEEELTWGVDSCVKVPPGAETVAELVIIEDIVTRDFRIENRLSGKVLVTITNLKENNSLVTIIEGNICDIIRGMPDYTAKGFRFDGPAAIYETRGQCIFRFGIEQKVRINEFSLNSSRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLN2</accession>
    <name>V6CLN2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-disulfide reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">trxr-1</name>
        <name evidence="18" type="ORF">C06G3.7</name>
        <name evidence="16" type="ORF">CELE_C06G3.7</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293761.1">
        <property type="nucleotide sequence ID" value="NM_001306832.3"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="V6CLN2"/>
    <dbReference type="GeneID" id="177466"/>
    <dbReference type="AGR" id="WB:WBGene00015553"/>
    <dbReference type="CTD" id="177466"/>
    <dbReference type="WormBase" id="C06G3.7b">
        <property type="protein sequence ID" value="CE54573"/>
        <property type="gene ID" value="WBGene00015553"/>
        <property type="gene designation" value="trxr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_4_1"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015553">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLN2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000190">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000004">
        <property type="entry name" value="Thioredoxin reductase 1, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006338">
        <property type="entry name" value="Thioredoxin/glutathione_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01438">
        <property type="entry name" value="TGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF8">
        <property type="entry name" value="THIOREDOXIN-DISULFIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0711">Selenium</keyword>
    <keyword evidence="7 16" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="15">
        <location>
            <begin position="140"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="14">
        <location>
            <begin position="503"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="16">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDK13467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="C06G3.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLN2"/>
        </source>
    </evidence>
    <sequence length="634" mass="70590" checksum="5ED57A18EC6D983C" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLN3</accession>
    <name>V6CLN3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Host attachment protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_H32C10.1</name>
        <name evidence="1 3" type="ORF">H32C10.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLN3"/>
    <dbReference type="SMR" id="V6CLN3"/>
    <dbReference type="AGR" id="WB:WBGene00019255"/>
    <dbReference type="WormBase" id="H32C10.1c">
        <property type="protein sequence ID" value="CE04688"/>
        <property type="gene ID" value="WBGene00019255"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030880_0_1_1"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019255">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLN3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="H32C10.1c"/>
        </source>
    </evidence>
    <sequence length="127" mass="14644" checksum="0D2B45B512D64A94" modified="2014-02-19" version="1">MKLEDVKYVYVIGDNPMSDVLGARLFDRYLRHGGVGRFDHLDLEAFDVNDGEKPRVRTRNVVERCISILVETGVHQDHVHINGMVKPISALIDNLSKGEQLKLQLPDFVEYDLHAAIRTILRRECYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLN7</accession>
    <name>V6CLN7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ztf-3</name>
        <name evidence="13" type="ORF">C53D5.4</name>
        <name evidence="11" type="ORF">CELE_C53D5.4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368396.1">
        <property type="nucleotide sequence ID" value="NM_001381400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLN7"/>
    <dbReference type="SMR" id="V6CLN7"/>
    <dbReference type="PeptideAtlas" id="V6CLN7"/>
    <dbReference type="GeneID" id="171617"/>
    <dbReference type="AGR" id="WB:WBGene00016905"/>
    <dbReference type="CTD" id="171617"/>
    <dbReference type="WormBase" id="C53D5.4c">
        <property type="protein sequence ID" value="CE49249"/>
        <property type="gene ID" value="WBGene00016905"/>
        <property type="gene designation" value="ztf-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_967190_0_0_1"/>
    <dbReference type="OrthoDB" id="5855904at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016905">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLN7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDK13478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C53D5.4c"/>
        </source>
    </evidence>
    <sequence length="288" mass="32927" checksum="B56E60EB2097D251" modified="2014-02-19" version="1">MKATGFIQEFTRRLLERSSKNIIKIPDNLSNVNQLTCLVKQFLREQQDLAVKVEKVQENQKNLSDFVKEKLTNCNCHVQLDVRNLLAKEMKLQDLRQDDGLDFSIKLPSTSSTDFTVSLNQVVDADAQQRFDLELLKMFGAGNIPHFQPPPDLYQHHHIPHTSQQVAQENLAMLANVPKLDDNNAYFDTFSPEKSGKRAKKRAAPSSAHEAQPNNGPYKCRDCEKTFRQKHGLNQHLLTHETNGAFECDGCGKRYSRQESVYRHQRSTPCTKYQNLTTVEHDDTGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLP1</accession>
    <name>V6CLP1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger homeobox protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">zfh-2</name>
        <name evidence="11" type="ORF">CELE_ZC123.3</name>
        <name evidence="13" type="ORF">ZC123.3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368417.1">
        <property type="nucleotide sequence ID" value="NM_001380630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLP1"/>
    <dbReference type="SMR" id="V6CLP1"/>
    <dbReference type="PeptideAtlas" id="V6CLP1"/>
    <dbReference type="GeneID" id="171670"/>
    <dbReference type="AGR" id="WB:WBGene00022518"/>
    <dbReference type="CTD" id="171670"/>
    <dbReference type="WormBase" id="ZC123.3f">
        <property type="protein sequence ID" value="CE49410"/>
        <property type="gene ID" value="WBGene00022518"/>
        <property type="gene designation" value="zfh-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003443_1_0_1"/>
    <dbReference type="OrthoDB" id="6417226at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022518">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLP1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000527">
        <property type="entry name" value="Zinc Finger and Homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000080">
        <property type="entry name" value="Zinc finger homeobox protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051968">
        <property type="entry name" value="ZnFinger_Homeobox_TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="449"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="144"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="451"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDK13524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="ZC123.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLP1"/>
        </source>
    </evidence>
    <sequence length="728" mass="81785" checksum="54B695F26EF58CAB" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLP2</accession>
    <name>V6CLP2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (cytosine(34)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.203</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nsun-2</name>
        <name evidence="13" type="ORF">CELE_Y48G8AL.5</name>
        <name evidence="15" type="ORF">Y48G8AL.5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.203" evidence="2"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293222.1">
        <property type="nucleotide sequence ID" value="NM_001306293.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLP2"/>
    <dbReference type="PeptideAtlas" id="V6CLP2"/>
    <dbReference type="GeneID" id="171697"/>
    <dbReference type="KEGG" id="cel:CELE_Y48G8AL.5"/>
    <dbReference type="AGR" id="WB:WBGene00021686"/>
    <dbReference type="CTD" id="171697"/>
    <dbReference type="WormBase" id="Y48G8AL.5b">
        <property type="protein sequence ID" value="CE49447"/>
        <property type="gene ID" value="WBGene00021686"/>
        <property type="gene designation" value="nsun-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_4_3_1"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021686">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLP2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="439"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDK13483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="Y48G8AL.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLP2"/>
        </source>
    </evidence>
    <sequence length="484" mass="55337" checksum="1EF0D1182F66A3D2" modified="2014-02-19" version="1">MVIANDVDMKRCYMLIHHTLKRFRTAACAVTCEDAARFPHISDSDGGLIQFDRVLADVICSGDGTLRKNPEIWKKWTPQDGLGLHRMQIAIARKGAQQLKVGGRMVYSTCSMNPIEDEAVVAQLLRDSKGSLKLVDTSSLLPELKRETGVVQWKVFDRDMKLYKSLEDISEEKMKKVIVSSLFPPTEQEAKEMNLHFTMRITPHAQDTGGFFVALIEKVSETSFDPSAANGPAWKKKKMFKDEPFTFLKLDDERWNDIRNHYGVDESFLYQNLFSRRLESNDANSRQLFYANDAVKNFVKENMSKVSIQNAGMKMFSRTEGKVENTRFRLSQEGIRYLFKFMQKQKVKIGTEDMLFMLKSDENLVPLEKLECKGDVRKQQNGTVVVYCDDDEPVCTWVGYHTIAPYISKEERLHLLRMMGVDCAEIELLMKSKRKEKAAQDREAAWARKEEAAKAAEPSSSSTDAPESAETLEIPEENVQEMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLP3</accession>
    <name>V6CLP3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ztf-3</name>
        <name evidence="13" type="ORF">C53D5.4</name>
        <name evidence="11" type="ORF">CELE_C53D5.4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360315.1">
        <property type="nucleotide sequence ID" value="NM_001373713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLP3"/>
    <dbReference type="SMR" id="V6CLP3"/>
    <dbReference type="GeneID" id="171617"/>
    <dbReference type="AGR" id="WB:WBGene00016905"/>
    <dbReference type="CTD" id="171617"/>
    <dbReference type="WormBase" id="C53D5.4b">
        <property type="protein sequence ID" value="CE28215"/>
        <property type="gene ID" value="WBGene00016905"/>
        <property type="gene designation" value="ztf-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855904at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016905">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLP3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDK13477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C53D5.4b"/>
        </source>
    </evidence>
    <sequence length="301" mass="34471" checksum="E9A740483043F168" modified="2014-02-19" version="1">MGEFIGNEEFQNFMKATGFIQEFTRRLLERSSKNIIKIPDNLSNVNQLTCLVKQFLREQQDLAVKVEKVQENQKNLSDFVKEKLTNCNCHVQLDVRNLLAKEMKLQDLRQDDGLDFSIKLPSTSSTDFTVSLNQVVDADAQQRFDLELLKMFGAGNIPHFQPPPDLYQHHHIPHTSQQVAQENLAMLANVPKLDDNNAYFDTFSPEKSGKRAKKRAAPSSAHEAQPNNGPYKCRDCEKTFRQKHGLNQHLLTHETNGAFECDGCGKRYSRQESVYRHQRSTPCTKYQNLTTVEHDDTGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLP6</accession>
    <name>V6CLP6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">znf-236</name>
        <name evidence="8" type="ORF">CELE_Y48G8AL.10</name>
        <name evidence="10" type="ORF">Y48G8AL.10</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293227.1">
        <property type="nucleotide sequence ID" value="NM_001306298.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLP6"/>
    <dbReference type="GeneID" id="3565634"/>
    <dbReference type="AGR" id="WB:WBGene00021689"/>
    <dbReference type="CTD" id="3565634"/>
    <dbReference type="WormBase" id="Y48G8AL.10c">
        <property type="protein sequence ID" value="CE49297"/>
        <property type="gene ID" value="WBGene00021689"/>
        <property type="gene designation" value="znf-236"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007369_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021689">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLP6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003272">
        <property type="entry name" value="gastrula zinc finger protein XlCGF67.1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002539">
        <property type="entry name" value="GD10244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDK13488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y48G8AL.10c"/>
        </source>
    </evidence>
    <sequence length="870" mass="99983" checksum="B0BD4DF2B1AE2402" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLP8</accession>
    <name>V6CLP8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pqn-22</name>
        <name evidence="4" type="ORF">C46G7.4</name>
        <name evidence="2" type="ORF">CELE_C46G7.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368419.1">
        <property type="nucleotide sequence ID" value="NM_001380256.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLP8"/>
    <dbReference type="PeptideAtlas" id="V6CLP8"/>
    <dbReference type="GeneID" id="177369"/>
    <dbReference type="AGR" id="WB:WBGene00004112"/>
    <dbReference type="CTD" id="177369"/>
    <dbReference type="WormBase" id="C46G7.4e">
        <property type="protein sequence ID" value="CE49474"/>
        <property type="gene ID" value="WBGene00004112"/>
        <property type="gene designation" value="pqn-22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004112">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLP8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C46G7.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLP8"/>
        </source>
    </evidence>
    <sequence length="527" mass="58591" checksum="2FD173C9AB25441F" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLP9</accession>
    <name>V6CLP9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="ORF">C53D5.5</name>
        <name evidence="8" type="ORF">CELE_C53D5.5</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001364826.1">
        <property type="nucleotide sequence ID" value="NM_001377821.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLP9"/>
    <dbReference type="SMR" id="V6CLP9"/>
    <dbReference type="IntAct" id="V6CLP9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="MEROPS" id="T03.A05"/>
    <dbReference type="GeneID" id="171619"/>
    <dbReference type="KEGG" id="cel:CELE_C53D5.5"/>
    <dbReference type="AGR" id="WB:WBGene00016906"/>
    <dbReference type="CTD" id="171619"/>
    <dbReference type="WormBase" id="C53D5.5b">
        <property type="protein sequence ID" value="CE49221"/>
        <property type="gene ID" value="WBGene00016906"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_4_2_1"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016906">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLP9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000005">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000006">
        <property type="entry name" value="Protein CBG05566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF69">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="424"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="476"/>
            <end position="477"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDK13482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="C53D5.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLP9"/>
        </source>
    </evidence>
    <sequence length="596" mass="65290" checksum="76191993BDD52E49" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLQ4</accession>
    <name>V6CLQ4_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Zasp-like motif domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">pqn-22</name>
        <name evidence="5" type="ORF">C46G7.4</name>
        <name evidence="3" type="ORF">CELE_C46G7.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293799.1">
        <property type="nucleotide sequence ID" value="NM_001306870.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLQ4"/>
    <dbReference type="PeptideAtlas" id="V6CLQ4"/>
    <dbReference type="GeneID" id="177369"/>
    <dbReference type="AGR" id="WB:WBGene00004112"/>
    <dbReference type="CTD" id="177369"/>
    <dbReference type="WormBase" id="C46G7.4j">
        <property type="protein sequence ID" value="CE49258"/>
        <property type="gene ID" value="WBGene00004112"/>
        <property type="gene designation" value="pqn-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919374at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004112">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLQ4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zasp-like motif" evidence="2">
        <location>
            <begin position="3"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C46G7.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLQ4"/>
        </source>
    </evidence>
    <sequence length="971" mass="109386" checksum="0BBEBBED869F9586" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLQ6</accession>
    <name>V6CLQ6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">sfrp-1</name>
        <name evidence="3" type="ORF">CELE_Y73B6BL.21</name>
        <name evidence="5" type="ORF">Y73B6BL.21</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13503.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293776.2">
        <property type="nucleotide sequence ID" value="NM_001306847.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLQ6"/>
    <dbReference type="PeptideAtlas" id="V6CLQ6"/>
    <dbReference type="GeneID" id="177401"/>
    <dbReference type="KEGG" id="cel:CELE_Y73B6BL.21"/>
    <dbReference type="AGR" id="WB:WBGene00022242"/>
    <dbReference type="CTD" id="177401"/>
    <dbReference type="WormBase" id="Y73B6BL.21b">
        <property type="protein sequence ID" value="CE50517"/>
        <property type="gene ID" value="WBGene00022242"/>
        <property type="gene designation" value="sfrp-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1416336_0_0_1"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022242">
        <property type="expression patterns" value="Expressed in embryo and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLQ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.120:FF:000027">
        <property type="entry name" value="Secreted Frizzled-Related Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTR" evidence="2">
        <location>
            <begin position="40"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13503.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y73B6BL.21b"/>
        </source>
    </evidence>
    <sequence length="189" mass="21852" checksum="1F8DBE8C6484A660" modified="2015-11-11" version="2">MANYGFPWPEMLSCEKFEDDDMCIKPMQPAKPPAGSSTTCTACSQVATYENLVDQFCRSHLVLKAKVIRDSPTHIRVRNGRSLKKGERRRGVSDVEIRLSSESDGSCPCNIPVKNQNEKLLVMASRQPDGKYLANLVLPWQKEKNFKRAIHQFQRLNCQSLGREIRESASRRPHYYEMRRHNTGRYQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLQ7</accession>
    <name>V6CLQ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">haf-6</name>
        <name evidence="1" type="ORF">CELE_Y48G8AL.11</name>
        <name evidence="3" type="ORF">Y48G8AL.11</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293231.1">
        <property type="nucleotide sequence ID" value="NM_001306302.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLQ7"/>
    <dbReference type="SMR" id="V6CLQ7"/>
    <dbReference type="PeptideAtlas" id="V6CLQ7"/>
    <dbReference type="GeneID" id="171694"/>
    <dbReference type="AGR" id="WB:WBGene00001816"/>
    <dbReference type="CTD" id="171694"/>
    <dbReference type="WormBase" id="Y48G8AL.11c">
        <property type="protein sequence ID" value="CE49154"/>
        <property type="gene ID" value="WBGene00001816"/>
        <property type="gene designation" value="haf-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_61_13_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001816">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLQ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Type_1_exporter"/>
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        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13492.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y48G8AL.11c"/>
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    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLQ7"/>
        </source>
    </evidence>
    <sequence length="67" mass="7565" checksum="3D25C38664196750" modified="2014-02-19" version="1">MVQEALNNVMKGRTVLIIAHRLSTIRSAQMIYVIKDKKALESGTHEQLMAKKGSLYRKLVEAHNVDS</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CE49418"/>
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        <property type="gene designation" value="hrpf-2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
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            <end position="134"/>
        </location>
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            <end position="23"/>
        </location>
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        <location>
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            <begin position="301"/>
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            <begin position="1"/>
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        <location>
            <begin position="49"/>
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        <location>
            <begin position="194"/>
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        <location>
            <begin position="318"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDK13508.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y73B6BL.33b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLR1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37456" checksum="F16D08454421C419" modified="2014-02-19" version="1">MSVDSGYDHGRRGGGGRYGDSSYDRGYDDYNRGSYGGRRDYGYNGGHDQGGRSDYGRGGDDPLRVYMRGLPYDADDHAIAAFFSPLRCHSVKIGINETGRPSGDAIAEFDNYNDLQVALSRNNQRMGRRYVELFDNRGAPGPMRRLLWKETSGTNASAAPAPDPILNGGRRGGGPPQRDSGYRAGPQAMPPSYRESRDPYGPREPRGYDIEPKYEPRGIPPRSAPIRAPPAAHGRAPDTWGSYGAASTGPSYDQSSAAGGYAASWDAYYASQAQSAYSAEPASTYPTAAHSAYGSGESYSYGASAGGAYDRQREPRDSQPTWAQQQQPSHHSAYGGWGAGAGDHRSGY</sequence>
</entry>
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        <submittedName>
            <fullName evidence="3">Zasp-like motif domain-containing protein</fullName>
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    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293809.1">
        <property type="nucleotide sequence ID" value="NM_001306880.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLR2"/>
    <dbReference type="PeptideAtlas" id="V6CLR2"/>
    <dbReference type="GeneID" id="177369"/>
    <dbReference type="AGR" id="WB:WBGene00004112"/>
    <dbReference type="CTD" id="177369"/>
    <dbReference type="WormBase" id="C46G7.4t">
        <property type="protein sequence ID" value="CE49359"/>
        <property type="gene ID" value="WBGene00004112"/>
        <property type="gene designation" value="pqn-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919374at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004112">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLR2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
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    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zasp-like motif" evidence="2">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="987"/>
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        <location>
            <begin position="174"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
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        <location>
            <begin position="503"/>
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        </location>
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        </location>
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        <location>
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    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="900"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C46G7.4t"/>
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    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLR2"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115672" checksum="0BE7E43ADB2338C1" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLR3</accession>
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        <submittedName>
            <fullName evidence="3">Homolog of Odr-2 (Two)</fullName>
        </submittedName>
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    <gene>
        <name evidence="3 5" type="primary">hot-9</name>
        <name evidence="5" type="ORF">C09B9.8</name>
        <name evidence="3" type="ORF">CELE_C09B9.8</name>
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    <organism evidence="3 4">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001293772.1">
        <property type="nucleotide sequence ID" value="NM_001306843.3"/>
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    <dbReference type="GeneID" id="3896791"/>
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    <dbReference type="CTD" id="3896791"/>
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        <property type="gene ID" value="WBGene00044484"/>
        <property type="gene designation" value="hot-9"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <dbReference type="Bgee" id="WBGene00044484">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline"/>
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        <property type="entry name" value="Ly-6-related"/>
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        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004744509" evidence="2">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C09B9.8b"/>
        </source>
    </evidence>
    <sequence length="190" mass="20940" checksum="8749F2DC1377438D" modified="2014-02-19" version="1">MLRMISFLLLFYLHPPIIQAYSSSSSSTADNQRCYSCMSKYYGALWRFAGYTRIYQEPGLFTDSCRDPQARGSDVPSTICKEKTNCVTMVEDLKIGTGAKGYIRGCWGSVFLFGFNRTGTVGALAEHSFCHTFNLTQLVSGGRPEESSINVCSCRGPLCNGSTINTSSTRTTILPILLATLIVIFMSLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLR6</accession>
    <name>V6CLR6_CAEEL</name>
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        <submittedName>
            <fullName evidence="11">UNC-44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">unc-44</name>
        <name evidence="13" type="ORF">B0350.2</name>
        <name evidence="11" type="ORF">CELE_B0350.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001380254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLR6"/>
    <dbReference type="SMR" id="V6CLR6"/>
    <dbReference type="PeptideAtlas" id="V6CLR6"/>
    <dbReference type="GeneID" id="177366"/>
    <dbReference type="AGR" id="WB:WBGene00006780"/>
    <dbReference type="CTD" id="177366"/>
    <dbReference type="WormBase" id="B0350.2j">
        <property type="protein sequence ID" value="CE49406"/>
        <property type="gene ID" value="WBGene00006780"/>
        <property type="gene designation" value="unc-44"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006780">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLR6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_UPA"/>
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    </dbReference>
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        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
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    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ZU5" evidence="10">
        <location>
            <begin position="175"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="10">
        <location>
            <begin position="334"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="9">
        <location>
            <begin position="670"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="814"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="897"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
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        <location>
            <begin position="903"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="950"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDK13513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="B0350.2j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="V6CLR6"/>
        </source>
    </evidence>
    <sequence length="982" mass="109491" checksum="1E364399B1944A93" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLR8</accession>
    <name>V6CLR8_CAEEL</name>
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        <submittedName>
            <fullName evidence="17">Dystrophin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">dys-1</name>
        <name evidence="17" type="ORF">CELE_F15D3.1</name>
        <name evidence="19" type="ORF">F15D3.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293243.1">
        <property type="nucleotide sequence ID" value="NM_001306314.3"/>
    </dbReference>
    <dbReference type="SMR" id="V6CLR8"/>
    <dbReference type="PeptideAtlas" id="V6CLR8"/>
    <dbReference type="GeneID" id="173038"/>
    <dbReference type="AGR" id="WB:WBGene00001131"/>
    <dbReference type="CTD" id="173038"/>
    <dbReference type="WormBase" id="F15D3.1i">
        <property type="protein sequence ID" value="CE49403"/>
        <property type="gene ID" value="WBGene00001131"/>
        <property type="gene designation" value="dys-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10057795at2759"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLR8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="EFh_DMD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056503">
        <property type="entry name" value="Spectrin_Dys-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="118" mass="13226" checksum="D4D191963329091E" modified="2014-02-19" version="1">MKALRHIQLTSRKAPSLLKKELSEPSTTHLIEKFMGRKVNGSRMSLNKKPSLPEVRGSPPSEKNNNNNSDFKGSNETIVLSSYFYTVESTSSPEDYTAVFGSRPKVARTPDTQSRSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>V6CM05</accession>
    <name>V6CM05_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">otub-2</name>
        <name evidence="13" type="ORF">CELE_Y50C1A.1</name>
        <name evidence="15" type="ORF">Y50C1A.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C64 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293262.1">
        <property type="nucleotide sequence ID" value="NM_001306333.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CM05"/>
    <dbReference type="SMR" id="V6CM05"/>
    <dbReference type="MEROPS" id="C64.A01"/>
    <dbReference type="GeneID" id="171633"/>
    <dbReference type="KEGG" id="cel:CELE_Y50C1A.1"/>
    <dbReference type="AGR" id="WB:WBGene00021733"/>
    <dbReference type="CTD" id="171633"/>
    <dbReference type="WormBase" id="Y50C1A.1b">
        <property type="protein sequence ID" value="CE49387"/>
        <property type="gene ID" value="WBGene00021733"/>
        <property type="gene designation" value="otub-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013263_1_0_1"/>
    <dbReference type="OrthoDB" id="10064699at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021733">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CM05">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF27">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="12">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="243"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDK13594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="Y50C1A.1b"/>
        </source>
    </evidence>
    <sequence length="499" mass="56275" checksum="270C1F75E1F4E3EA" modified="2014-02-19" version="1">MWGVHDRQLSLRETLYELLTNGARKEAIRRRWKWVENHMNQSNGLALTLSENEWELEWDVVLGLSSPLPRKQEDNGSNSTDQIYESLEAIHVFALAHVLKRPVVVVSDTILRNAKGEELSPVAFGGIYLPLECPPSQCHRSPLVLCYDSAHFSPLVLMRTETNNKQIIPIIDVNRNLLPVHFAVDPGESFDWSKLETNSNTQTTTDMSQIDKLALISQYMDIIRLDVRRGSIRSSRRVRSAHAQLLTESRGENGQNLPQKSIKPRDLSAHSSDEQPSNNAKGMTLASSGIGSGRHEKWRLINEIRTHVLRTFRISSSTRGKEKLIDTDDCIARMNSTCVLASELLPTHHQYMDKIINEYMKSAKQRFQQNQRTQSDSRKRISRSFSASSLMLTCIGCDSEFKPASQVTNIMCDQCFAWQKMSVLTSNCDQFMGNSGPPCKSSTLPSFGSNDSNQNDKENIVEVLNVVPKDGAKTLTSMRAVEDENGVVHYYMDDEVADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>V6CM07</accession>
    <name>V6CM07_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rps-8</name>
        <name evidence="6" type="ORF">CELE_F42C5.8</name>
        <name evidence="8" type="ORF">F42C5.8</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368426.1">
        <property type="nucleotide sequence ID" value="NM_001380319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CM07"/>
    <dbReference type="SMR" id="V6CM07"/>
    <dbReference type="PeptideAtlas" id="V6CM07"/>
    <dbReference type="GeneID" id="177503"/>
    <dbReference type="KEGG" id="cel:CELE_F42C5.8"/>
    <dbReference type="AGR" id="WB:WBGene00004477"/>
    <dbReference type="CTD" id="177503"/>
    <dbReference type="WormBase" id="F42C5.8b">
        <property type="protein sequence ID" value="CE49256"/>
        <property type="gene ID" value="WBGene00004477"/>
        <property type="gene designation" value="rps-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_1_1_1"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004477">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CM07">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDK13600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F42C5.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="V6CM07"/>
        </source>
    </evidence>
    <sequence length="127" mass="14434" checksum="20DBB06DC7E25F2B" modified="2014-02-19" version="1">MYNATNNELVRTKTLVKGAIISVDAAPFRQWYEAHYALPLARKKNAKLSEEDNAILNKKRSHHTMKKYTERQKTAAVDALLIEQFNTGRLLARISSSPGQVGQANGYILEGKELDFYLRKIRAKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>V6CM09</accession>
    <name>V6CM09_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine phosphatase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F42C5.5</name>
        <name evidence="2 4" type="ORF">F42C5.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CM09"/>
    <dbReference type="SMR" id="V6CM09"/>
    <dbReference type="AGR" id="WB:WBGene00018347"/>
    <dbReference type="WormBase" id="F42C5.5b">
        <property type="protein sequence ID" value="CE49159"/>
        <property type="gene ID" value="WBGene00018347"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081389_0_0_1"/>
    <dbReference type="OrthoDB" id="5775049at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018347">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CM09">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF24">
        <property type="entry name" value="PROTEIN-TYROSINE PHOSPHATASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein-tyrosine phosphatase catalytic" evidence="1">
        <location>
            <begin position="66"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F42C5.5b"/>
        </source>
    </evidence>
    <sequence length="216" mass="24787" checksum="5758DE7F496AAF3B" modified="2014-02-19" version="1">MWIYNVQTVVCLVLPEEAGGYFVPKEGETFTSFQKYQIKTIGIFDEKQGVTVYQCELKSYKAPKKLNRRMVYIICCDTSVGSIRSPRQQTVIMEYMWAFEETNAIENEVALADATTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDFFSSVYTFFAFCVQSSAVSETNENYAKTMEIVKDLLVKKNKEEKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>V6CM14</accession>
    <name>V6CM14_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transmembrane protein 85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">perm-3</name>
        <name evidence="11" type="ORF">CELE_ZK616.6</name>
        <name evidence="13" type="ORF">ZK616.6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368428.1">
        <property type="nucleotide sequence ID" value="NM_001380228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CM14"/>
    <dbReference type="SMR" id="V6CM14"/>
    <dbReference type="PeptideAtlas" id="V6CM14"/>
    <dbReference type="GeneID" id="177324"/>
    <dbReference type="KEGG" id="cel:CELE_ZK616.6"/>
    <dbReference type="AGR" id="WB:WBGene00022776"/>
    <dbReference type="CTD" id="177324"/>
    <dbReference type="WormBase" id="ZK616.6b">
        <property type="protein sequence ID" value="CE49247"/>
        <property type="gene ID" value="WBGene00022776"/>
        <property type="gene designation" value="perm-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098404_1_0_1"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022776">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CM14">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDK13604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="ZK616.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="V6CM14"/>
        </source>
    </evidence>
    <sequence length="113" mass="12406" checksum="2D650C04C2ADA4B0" modified="2014-02-19" version="1">MGPAKSLPMNMFMMYMAGGGVSIFPIMMVGMMVFRPLKALFAVNSTFKPLESPATGSMFIHKLIFCLGNLGAIGLAIYKVHTMGLLPNTPSDWLEFIPQPGRAQYSIIDEVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>V6CM19</accession>
    <name>V6CM19_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">col-45</name>
        <name evidence="4" type="ORF">CELE_F53G12.7</name>
        <name evidence="6" type="ORF">F53G12.7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293264.1">
        <property type="nucleotide sequence ID" value="NM_001306335.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CM19"/>
    <dbReference type="GeneID" id="171605"/>
    <dbReference type="KEGG" id="cel:CELE_F53G12.7"/>
    <dbReference type="AGR" id="WB:WBGene00000622"/>
    <dbReference type="CTD" id="171605"/>
    <dbReference type="WormBase" id="F53G12.7b">
        <property type="protein sequence ID" value="CE49336"/>
        <property type="gene ID" value="WBGene00000622"/>
        <property type="gene designation" value="col-45"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001074_4_2_1"/>
    <dbReference type="OrthoDB" id="5871495at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000622">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CM19">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF365">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDK13609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F53G12.7b"/>
        </source>
    </evidence>
    <sequence length="258" mass="25196" checksum="EA2953A192A786B2" modified="2014-02-19" version="1">MKMARSRGRDEELVARTKRAVKGTWLFGQYIPDRSSRNRRQQYAEAAGGGGGAPHAECRRGPPGPPGDDGVDGTDGKDGAPGTDGKDGQVPQGPADGGYQEGPSDAVEACTRECPPGPPGPTGAPGDKGSRGYPGESGEPGTPGSAGPKGNAGPAGPPGPPGYPGRPGETGDHGKTIAGEAPPGPPGRQGEMGPQGPPGPPGPRGKDGAGGEKGAPGDQGNPGPYGKPGQPGAPGPDGSAGEKGGCDHCPPPRTPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>V6CM34</accession>
    <name>V6CM34_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Raf homolog serine/threonine-protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Abnormal cell lineage protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">lin-45</name>
        <name evidence="20" type="ORF">CELE_Y73B6A.5</name>
        <name evidence="22" type="ORF">Y73B6A.5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with cdf-1 in a zinc-dependent manner which promotes its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368430.1">
        <property type="nucleotide sequence ID" value="NM_001380288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CM34"/>
    <dbReference type="SMR" id="V6CM34"/>
    <dbReference type="GeneID" id="177436"/>
    <dbReference type="AGR" id="WB:WBGene00003030"/>
    <dbReference type="CTD" id="177436"/>
    <dbReference type="WormBase" id="Y73B6A.5f">
        <property type="protein sequence ID" value="CE49394"/>
        <property type="gene ID" value="WBGene00003030"/>
        <property type="gene designation" value="lin-45"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023684_1_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003030">
        <property type="expression patterns" value="Expressed in material anatomical entity and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CM34">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20811">
        <property type="entry name" value="C1_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14062">
        <property type="entry name" value="STKc_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000024">
        <property type="entry name" value="B-Raf proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000366">
        <property type="entry name" value="Raf homolog serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF262">
        <property type="entry name" value="RAF HOMOLOG SERINE_THREONINE-PROTEIN KINASE RAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RBD" evidence="19">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="18">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="437"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="214"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="339"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDK13625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="Y73B6A.5f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="V6CM34"/>
        </source>
    </evidence>
    <sequence length="769" mass="85681" checksum="CF8EF397C584F445" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>V6CM38</accession>
    <name>V6CM38_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Raf homolog serine/threonine-protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Abnormal cell lineage protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">lin-45</name>
        <name evidence="20" type="ORF">CELE_Y73B6A.5</name>
        <name evidence="22" type="ORF">Y73B6A.5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with cdf-1 in a zinc-dependent manner which promotes its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293843.1">
        <property type="nucleotide sequence ID" value="NM_001306914.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CM38"/>
    <dbReference type="SMR" id="V6CM38"/>
    <dbReference type="GeneID" id="177436"/>
    <dbReference type="AGR" id="WB:WBGene00003030"/>
    <dbReference type="CTD" id="177436"/>
    <dbReference type="WormBase" id="Y73B6A.5e">
        <property type="protein sequence ID" value="CE49308"/>
        <property type="gene ID" value="WBGene00003030"/>
        <property type="gene designation" value="lin-45"/>
    </dbReference>
    <dbReference type="OrthoDB" id="774951at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003030">
        <property type="expression patterns" value="Expressed in material anatomical entity and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CM38">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20811">
        <property type="entry name" value="C1_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14062">
        <property type="entry name" value="STKc_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000024">
        <property type="entry name" value="B-Raf proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000366">
        <property type="entry name" value="Raf homolog serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF262">
        <property type="entry name" value="RAF HOMOLOG SERINE_THREONINE-PROTEIN KINASE RAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RBD" evidence="19">
        <location>
            <begin position="53"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="18">
        <location>
            <begin position="138"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="449"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="226"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="351"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDK13624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="Y73B6A.5e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="V6CM38"/>
        </source>
    </evidence>
    <sequence length="781" mass="87016" checksum="BB652FE8305DCE48" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>W6RQY6</accession>
    <name>W6RQY6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">pmk-2</name>
        <name evidence="10" type="ORF">CELE_F42G8.3</name>
        <name evidence="12" type="ORF">F42G8.3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368441.1">
        <property type="nucleotide sequence ID" value="NM_001380353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RQY6"/>
    <dbReference type="SMR" id="W6RQY6"/>
    <dbReference type="GeneID" id="177611"/>
    <dbReference type="AGR" id="WB:WBGene00004056"/>
    <dbReference type="CTD" id="177611"/>
    <dbReference type="WormBase" id="F42G8.3d">
        <property type="protein sequence ID" value="CE49547"/>
        <property type="gene ID" value="WBGene00004056"/>
        <property type="gene designation" value="pmk-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004056">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RQY6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM63504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F42G8.3d"/>
        </source>
    </evidence>
    <sequence length="194" mass="22609" checksum="A90A510C4419D74B" modified="2014-04-16" version="1">MTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEEARNYIKNRSPIIRQDFVTLFPMASPYALELLEMMLILDPDRRISVSSALRHDYLREYSVPNDEPVAMDTVTIDPAEERATTLSDWRELIWNEIRLFQNSARRLSFVSCTDTEEEPMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6RQZ7</accession>
    <name>W6RQZ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IntraMembrane Protease (IMPAS) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">imp-3</name>
        <name evidence="4" type="ORF">C33H5.11</name>
        <name evidence="2" type="ORF">CELE_C33H5.11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294164.1">
        <property type="nucleotide sequence ID" value="NM_001307235.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RQZ7"/>
    <dbReference type="GeneID" id="177565"/>
    <dbReference type="AGR" id="WB:WBGene00016378"/>
    <dbReference type="CTD" id="177565"/>
    <dbReference type="WormBase" id="C33H5.11c">
        <property type="protein sequence ID" value="CE49479"/>
        <property type="gene ID" value="WBGene00016378"/>
        <property type="gene designation" value="imp-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040348_0_0_1"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016378">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RQZ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM63519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C33H5.11c"/>
        </source>
    </evidence>
    <sequence length="98" mass="10950" checksum="C1E6B821D7C7F995" modified="2014-04-16" version="1">MILVPRDTKGNKQSLAALDIMVPGVFLNVVLKYSSMYDTNLFAITFAAVFASLVFSVFFSIWRSKTTPAMVLPAISAIIFSIGFANHTDDLWKFMIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBN2</accession>
    <name>A0A131MBN2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">arrd-12</name>
        <name evidence="3" type="ORF">CELE_R06B9.2</name>
        <name evidence="5" type="ORF">R06B9.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309575.1">
        <property type="nucleotide sequence ID" value="NM_001322758.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBN2"/>
    <dbReference type="SMR" id="A0A131MBN2"/>
    <dbReference type="GeneID" id="187636"/>
    <dbReference type="KEGG" id="cel:CELE_R06B9.2"/>
    <dbReference type="AGR" id="WB:WBGene00011053"/>
    <dbReference type="CTD" id="187636"/>
    <dbReference type="WormBase" id="R06B9.2a">
        <property type="protein sequence ID" value="CE51535"/>
        <property type="gene ID" value="WBGene00011053"/>
        <property type="gene designation" value="arrd-12"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011053">
        <property type="expression patterns" value="Expressed in material anatomical entity and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBN2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
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    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF155">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CZR14491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="R06B9.2a"/>
        </source>
    </evidence>
    <sequence length="185" mass="21288" checksum="1E9953D9F21C24B5" modified="2016-05-11" version="1">MPEIFVLFDKPNAVYAAGQKISGRVVFSTASQQNPRWIDVQLHGRSHTFFTRQESETKTNSKGESETKTHTVHYTATAKHLDTAVPLWRKTDKAARLLPGKYEWQFWFQLPCSVLPPSFEGNNGNIRYWVRAEVSRSWKFNIVDESSFEIAPFLDLNTMPIARTPLDGFAVKNLGCCCFRNERER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBN3</accession>
    <name>A0A131MBN3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">catp-2</name>
        <name evidence="12" type="ORF">C02E7.1</name>
        <name evidence="10" type="ORF">CELE_C02E7.1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309616.1">
        <property type="nucleotide sequence ID" value="NM_001322555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBN3"/>
    <dbReference type="SMR" id="A0A131MBN3"/>
    <dbReference type="GeneID" id="182114"/>
    <dbReference type="KEGG" id="cel:CELE_C02E7.1"/>
    <dbReference type="AGR" id="WB:WBGene00015338"/>
    <dbReference type="CTD" id="182114"/>
    <dbReference type="WormBase" id="C02E7.1b">
        <property type="protein sequence ID" value="CE51374"/>
        <property type="gene ID" value="WBGene00015338"/>
        <property type="gene designation" value="catp-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015338">
        <property type="expression patterns" value="Expressed in adult organism"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBN3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000064">
        <property type="entry name" value="Cation transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF5">
        <property type="entry name" value="CATION-TRANSPORTING P-TYPE ATPASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="871"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="971"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1005"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CZR14537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C02E7.1b"/>
        </source>
    </evidence>
    <sequence length="1045" mass="116738" checksum="CBC3184612639491" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MBN5</accession>
    <name>A0A131MBN5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Concentrative nucleoside transporter C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">slc-28.1</name>
        <name evidence="3" type="ORF">CELE_F27E11.1</name>
        <name evidence="5" type="ORF">F27E11.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309638.1">
        <property type="nucleotide sequence ID" value="NM_001322519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MBN5"/>
    <dbReference type="SMR" id="A0A131MBN5"/>
    <dbReference type="GeneID" id="178770"/>
    <dbReference type="KEGG" id="cel:CELE_F27E11.1"/>
    <dbReference type="AGR" id="WB:WBGene00017867"/>
    <dbReference type="CTD" id="178770"/>
    <dbReference type="WormBase" id="F27E11.1b">
        <property type="protein sequence ID" value="CE51510"/>
        <property type="gene ID" value="WBGene00017867"/>
        <property type="gene designation" value="slc-28.1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017867">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MBN5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF20">
        <property type="entry name" value="SODIUM_NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CZR14563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F27E11.1b"/>
        </source>
    </evidence>
    <sequence length="110" mass="11424" checksum="8EA8F786AF50075F" modified="2016-05-11" version="1">MGSKTAVNEFVAYDKLGQLQKEGKLDPKSVLVATYALCGFSNFGSMGIQMEVIGGLAPGRKTVASKVMLRALCAGAIACFMNATVAGILISDPVVCNSANSNSTCFRIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DQ66</accession>
    <name>A0A3B1DQ66_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diacylglycerol kinase</fullName>
            <shortName evidence="7">DAG kinase</shortName>
            <ecNumber evidence="7">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">dgk-5</name>
        <name evidence="10" type="ORF">CELE_K06A1.6</name>
        <name evidence="12" type="ORF">K06A1.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="7"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="VAY52109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355400.1">
        <property type="nucleotide sequence ID" value="NM_001368593.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1DQ66"/>
    <dbReference type="SMR" id="A0A3B1DQ66"/>
    <dbReference type="GeneID" id="174068"/>
    <dbReference type="AGR" id="WB:WBGene00019428"/>
    <dbReference type="CTD" id="174068"/>
    <dbReference type="WormBase" id="K06A1.6c">
        <property type="protein sequence ID" value="CE52753"/>
        <property type="gene ID" value="WBGene00019428"/>
        <property type="gene designation" value="dgk-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019428">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1DQ66">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20802">
        <property type="entry name" value="C1_DGK_typeIV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20855">
        <property type="entry name" value="C1_DGK_typeIV_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000022">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000037">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056383">
        <property type="entry name" value="DGKI-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF80">
        <property type="entry name" value="EYE-SPECIFIC DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23578">
        <property type="entry name" value="DGKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="9">
        <location>
            <begin position="463"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VAY52109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="K06A1.6c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="A0A3B1DQ66"/>
        </source>
    </evidence>
    <sequence length="986" mass="110494" checksum="DA16EAD52216DA9F" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DQ87</accession>
    <name>A0A3B1DQ87_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">glb-9</name>
        <name evidence="7" type="ORF">C28F5.2</name>
        <name evidence="5" type="ORF">CELE_C28F5.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="VAY52120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370991.1">
        <property type="nucleotide sequence ID" value="NM_001383889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1DQ87"/>
    <dbReference type="SMR" id="A0A3B1DQ87"/>
    <dbReference type="GeneID" id="182985"/>
    <dbReference type="AGR" id="WB:WBGene00016184"/>
    <dbReference type="CTD" id="182985"/>
    <dbReference type="WormBase" id="C28F5.2c">
        <property type="protein sequence ID" value="CE52715"/>
        <property type="gene ID" value="WBGene00016184"/>
        <property type="gene designation" value="glb-9"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5848155at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016184">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1DQ87">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF11">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VAY52120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C28F5.2c"/>
        </source>
    </evidence>
    <sequence length="137" mass="15797" checksum="B810A5D31EECF9B5" modified="2018-12-05" version="1">MEVHIKLTTKFFDELLVSLDDETEFVNKIRGIGSAHAILAKGSNFSSDIWERLGEIAMERVCSHEVVTKTREASRAWRTLIAILIDELRGGFEGELRQHRKSSSTDQIEMGKMEDEEELHAKLQQLRMDYNQTLPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P6NPD2</accession>
    <name>A0A3P6NPD2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SANT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">swsn-1</name>
        <name evidence="7" type="ORF">CELE_Y113G7B.23</name>
        <name evidence="9" type="ORF">Y113G7B.23</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="VDJ65119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360451.1">
        <property type="nucleotide sequence ID" value="NM_001373203.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P6NPD2"/>
    <dbReference type="SMR" id="A0A3P6NPD2"/>
    <dbReference type="GeneID" id="180324"/>
    <dbReference type="AGR" id="WB:WBGene00004203"/>
    <dbReference type="CTD" id="180324"/>
    <dbReference type="WormBase" id="Y113G7B.23f">
        <property type="protein sequence ID" value="CE52835"/>
        <property type="gene ID" value="WBGene00004203"/>
        <property type="gene designation" value="swsn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3P6NPD2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
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        </source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A0A5E4M3F7"/>
        </source>
    </evidence>
    <sequence length="502" mass="56208" checksum="A9F468EA955ACFA7" modified="2019-11-13" version="1">MSTYAAYTTSTYQGRGLASGTYASGFGQLVSGMSSAGAICTTQIRDAREREKREIGLLNDRLADYIEKVRFLEAQNRCLSHDIDILRNGFSGGGHVSGLFDAEINQAKHILEQTTAHRSTFERDITGLSAEIEVFRKKWLDAVNAVKAHREDHDVDLDRLAKIEAEISLFKRKIRIVEEDVIRIRRENDGIYNEIARIKQLTHNEIALKNERSLNVSDLLQRINLLQTENNVRIEQELVFIRRDTTADNRDYFRHELQAAIRDIRADYEAISIRNRQDIEVWYREQIRKIQDESVRVNPDLYKEELISIRTTVTNVRSRLAEVEGRNFFLERLIDDLKNNEEAKFFEISLAERDAQIATLRDQCTELSIQMEKLCDNEISLRAEIERYRILLNGANVTTYTSNTHGSGSGIAVGGVVGGSTRVISQTTRTHSSSNTSYSNVPASRGGYSISGNVGGISVGGTIGSHGASAHATGGIIGSGVQAHRGSGTYQQSHHSYSSSNH</sequence>
</entry>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AGR" id="WB:WBGene00020294"/>
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        <property type="gene ID" value="WBGene00020294"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5916543at2759"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VVC12377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T06F4.1c"/>
        </source>
    </evidence>
    <sequence length="168" mass="19204" checksum="8566E87BA7F0D831" modified="2019-11-13" version="1">MSVYVLNLADAEGNMVKGESYKFIRMADDLHDVASYLNDMRICFIALTVTGYIVLVIYLFVFCFRRSRRNQPRRRYGDYQLESQREFNNTQTTNDEMLTTVRSDANSSYMGRNHHRGRIRQEKVASEYGANVHAPRAHEPSADDATRGGQRRIGGETPNTTHYNGGAN</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
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            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
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        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
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        <property type="protein sequence ID" value="CE53632"/>
        <property type="gene ID" value="WBGene00000905"/>
        <property type="gene designation" value="daf-9"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
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            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
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        </location>
        <ligand>
            <name>heme</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
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        </ligandPart>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VVC12387.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="T13C5.1c"/>
        </source>
    </evidence>
    <sequence length="536" mass="62419" checksum="D55F4F397DC612AB" modified="2019-11-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5E4M3L3</accession>
    <name>A0A5E4M3L3_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T23E7.2</name>
        <name evidence="2 4" type="ORF">T23E7.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VVC12397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CAG4685892.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>A0A8D9I9L4</accession>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51290"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8D9I9L4"/>
        </source>
    </evidence>
    <sequence length="791" mass="89328" checksum="357C25EB0DEBD848" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>A9D602</accession>
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    <organism evidence="2 3">
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            <taxon>Rhabditida</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD71699.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2008-06-10" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>B2L044</accession>
    <name>B2L044_CAEEL</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="16">
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        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2008" name="Endocrinology" volume="149" first="2826" last="2839">
            <title>Discovery of a cholecystokinin-gastrin-like signaling system in nematodes.</title>
            <authorList>
                <person name="Janssen T."/>
                <person name="Meelkop E."/>
                <person name="Lindemans M."/>
                <person name="Verstraelen K."/>
                <person name="Husson S.J."/>
                <person name="Temmerman L."/>
                <person name="Nachman R.J."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="18339709"/>
            <dbReference type="DOI" id="10.1210/en.2007-1772"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EU346943">
        <property type="protein sequence ID" value="ACA81683.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCU83363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370897.1">
        <property type="nucleotide sequence ID" value="NM_001384036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B2L044"/>
    <dbReference type="SMR" id="B2L044"/>
    <dbReference type="GeneID" id="175341"/>
    <dbReference type="AGR" id="WB:WBGene00021439"/>
    <dbReference type="CTD" id="175341"/>
    <dbReference type="WormBase" id="Y39A3B.5e">
        <property type="protein sequence ID" value="CE48226"/>
        <property type="gene ID" value="WBGene00021439"/>
        <property type="gene designation" value="ckr-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_6_3_1"/>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021439">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B2L044">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14993">
        <property type="entry name" value="7tmA_CCKR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000869">
        <property type="entry name" value="CholecystoKinin Receptor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009126">
        <property type="entry name" value="Cholcskin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF75">
        <property type="entry name" value="CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01822">
        <property type="entry name" value="CCYSTOKININR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9 13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="35"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACA81683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCU83363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="Y39A3B.5e"/>
        </source>
    </evidence>
    <sequence length="399" mass="45334" checksum="B58B4E165A27BC89" modified="2008-06-10" version="1">MSTVHQEEICRFRGTTENYTIAVTFFMIFLLSVVGNSVVLIVIIKQRAMRSITNIYLMNLAASDMMLSVVCMPPTLVSMVMNCWMFGNYMCKILAYLQPVVVTASAYTLAVIAFERYFAICKPLHSRIWQTRSHAYAMITLVWVIAIAANILMLFMYEQQTYSSNGYTCAPIHPPIYHFAYQVYMTVVLLVIPLVVMAGLYGNVITSLKSGIKLEIASVDPPLATATTTAIVASMTDEQKLSFWNKLSNKLTFSQQDKTVQHPNFGHRKSDTSICLENPSLRSTHTQKSAMAKQRVIKMLIVVVIIFFCCWTPSYIWWLLLIAGDSFQSLNLSVWNSDINTFITLLTYISSCTNPITYCFLNKKFRNAVYATFGRKKNMRHHFQKVGLVDIHSTTSSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-06-10" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>B2L045</accession>
    <name>B2L045_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cholecystokinin receptor 2 splice isoform b</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">ckr-2</name>
        <name evidence="17" type="ORF">CELE_Y39A3B.5</name>
        <name evidence="16 19" type="ORF">Y39A3B.5</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2008" name="Endocrinology" volume="149" first="2826" last="2839">
            <title>Discovery of a cholecystokinin-gastrin-like signaling system in nematodes.</title>
            <authorList>
                <person name="Janssen T."/>
                <person name="Meelkop E."/>
                <person name="Lindemans M."/>
                <person name="Verstraelen K."/>
                <person name="Husson S.J."/>
                <person name="Temmerman L."/>
                <person name="Nachman R.J."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="18339709"/>
            <dbReference type="DOI" id="10.1210/en.2007-1772"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EU346944">
        <property type="protein sequence ID" value="ACA81684.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCU83364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293648.1">
        <property type="nucleotide sequence ID" value="NM_001306719.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B2L045"/>
    <dbReference type="SMR" id="B2L045"/>
    <dbReference type="GeneID" id="175341"/>
    <dbReference type="KEGG" id="cel:CELE_Y39A3B.5"/>
    <dbReference type="AGR" id="WB:WBGene00021439"/>
    <dbReference type="CTD" id="175341"/>
    <dbReference type="WormBase" id="Y39A3B.5f">
        <property type="protein sequence ID" value="CE48324"/>
        <property type="gene ID" value="WBGene00021439"/>
        <property type="gene designation" value="ckr-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021439">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B2L045">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14993">
        <property type="entry name" value="7tmA_CCKR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009126">
        <property type="entry name" value="Cholcskin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF75">
        <property type="entry name" value="CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01822">
        <property type="entry name" value="CCYSTOKININR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9 13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="35"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACA81684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCU83364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="Y39A3B.5f"/>
        </source>
    </evidence>
    <sequence length="464" mass="52663" checksum="3CD79D3967C4991E" modified="2008-06-10" version="1">MSTVHQEEICRFRGTTENYTIAVTFFMIFLLSVVGNSVVLIVIIKQRAMRSITNIYLMNLAASDMMLSVVCMPPTLVSMVMNCWMFGNYMCKILAYLQPVVVTASAYTLAVIAFERYFAICKPLHSRIWQTRSHAYAMITLVWVIAIAANILMLFMYEQQTYSSNGYTCAPIHPPIYHFAYQVYMTVVLLVIPLVVMAGLYGNVITSLKSGIKLEIASVDPPLATATTTAIVASMTDEQKLSFWNKLSNKLTFSQQDKTVQHPNFGHRKSDTSICLENPSLRSTHTQKSAMAKQRVIKMLIVVVIIFFCCWTPSYIWWLLLIAGDSFQSLNLSVWNSDINTFITLLTYISSCTNPITYCFLNKKFRNAVYATFGRKKNMRHHFQKVYIPVNGGTNYTNKGEPRQIINRSVSSTFTPQHQVVFNDISIDSSSRKKDGSHTLISRTVHASLIHHNKVRKDESDAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>F9UKU6</accession>
    <name>F9UKU6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Patterned Expression Site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pes-5</name>
        <name evidence="2" type="ORF">CELE_T27D12.4</name>
        <name evidence="4" type="ORF">T27D12.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAB60581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359621.1">
        <property type="nucleotide sequence ID" value="NM_001373797.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F9UKU6"/>
    <dbReference type="GeneID" id="174819"/>
    <dbReference type="AGR" id="WB:WBGene00003979"/>
    <dbReference type="CTD" id="174819"/>
    <dbReference type="WormBase" id="T27D12.4c">
        <property type="protein sequence ID" value="CE25547"/>
        <property type="gene ID" value="WBGene00003979"/>
        <property type="gene designation" value="pes-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573956_0_0_1"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003979">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F9UKU6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB60581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T27D12.4c"/>
        </source>
    </evidence>
    <sequence length="312" mass="36641" checksum="1AA12ACF22B3B96C" modified="2011-10-19" version="1">MNRPFHSNESFRRSPSLERNYRGGSQNFSNASQTSDQQFHSNRCPAHEPRQFENDYHYHSRSPSFDRRSTQNQRRSSSPRNYERQGYFQRSSSPESGSPGGYRPRSQSPPARHPNFEDRYPQPPSDNYTPMRSLKSPEIDPIDFDRLRIELLKPEPVYVYRRQLEPIPNQQNNVIDNEPWVPDTAQANDVPSCLFHTNGYKNAIKSRPMREICNESYVNRKIRRPCVFCNKQHSVDECHEITNVEKRREFLEDAGICTRCLGRHSIRNCFNRAHYECDYCSDEDPDVEPHHSCLCPLPGTKTEFVDMSLFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G4RZ35</accession>
    <name>G4RZ35_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enhanced RNAI (RNA interference)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">eri-6</name>
        <name evidence="3" type="ORF">C41D11.1</name>
        <name evidence="1" type="ORF">CELE_C41D11.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD73359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380040.1">
        <property type="nucleotide sequence ID" value="NM_001392154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4RZ35"/>
    <dbReference type="GeneID" id="172050"/>
    <dbReference type="AGR" id="WB:WBGene00016561"/>
    <dbReference type="CTD" id="172050"/>
    <dbReference type="WormBase" id="C41D11.1f">
        <property type="protein sequence ID" value="CE43740"/>
        <property type="gene ID" value="WBGene00016561"/>
        <property type="gene designation" value="eri-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122537_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016561">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G4RZ35">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD73359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C41D11.1f"/>
        </source>
    </evidence>
    <sequence length="191" mass="21921" checksum="62AE7C1D8CE5F10A" modified="2012-01-25" version="1">MLESQLSQRQTEFEYRSANAAANSFTRKDHGKLYHCFDIKNQDSTSVSDTMTCRCSMKPCVFYLDSLPAAKTPSLTQLRRIVVLMQQKPSQKIDPKEMLLMTSMHLPFPMQEPSTEYFNAISGCSTSYICVEEMGIGFSFRRHVEKLWMKNLPPATNGTDKAANDLKNQLKVRRNVGKHDRTSRYARKSHN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>G5EEA1-2</accession>
    <name>LIM4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of LIM/homeobox protein lim-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lim-4</name>
        <name evidence="4" type="ORF">ZC64.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="1999" name="Genes Dev." volume="13" first="1794" last="1806">
            <title>Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4.</title>
            <authorList>
                <person name="Sagasti A."/>
                <person name="Hobert O."/>
                <person name="Troemel E.R."/>
                <person name="Ruvkun G."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="10421632"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ARG-243 AND 284-GLN--ASP-355</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2003" name="Dev. Biol." volume="263" first="81" last="102">
            <title>LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system.</title>
            <authorList>
                <person name="Tsalik E.L."/>
                <person name="Niacaris T."/>
                <person name="Wenick A.S."/>
                <person name="Pau K."/>
                <person name="Avery L."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="14568548"/>
            <dbReference type="DOI" id="10.1016/S0012-1606(03)00447-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 284-GLN--ASP-355</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2005" name="Dev. Biol." volume="286" first="618" last="628">
            <title>Cell-type specific regulation of serotonergic identity by the C. elegans LIM-homeodomain factor LIM-4.</title>
            <authorList>
                <person name="Zheng X."/>
                <person name="Chung S."/>
                <person name="Tanabe T."/>
                <person name="Sze J.Y."/>
            </authorList>
            <dbReference type="PubMed" id="16168406"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2005.08.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 284-GLN--ASP-355</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2015" name="EMBO J." volume="34" first="2574" last="2589">
            <title>Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG-box transcription factor SOX-2.</title>
            <authorList>
                <person name="Alqadah A."/>
                <person name="Hsieh Y.W."/>
                <person name="Vidal B."/>
                <person name="Chang C."/>
                <person name="Hobert O."/>
                <person name="Chuang C.F."/>
            </authorList>
            <dbReference type="PubMed" id="26341465"/>
            <dbReference type="DOI" id="10.15252/embj.201592188"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SOX-2</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="e1005480" last="e1005480">
            <title>The Evolutionarily Conserved LIM Homeodomain Protein LIM-4/LHX6 Specifies the Terminal Identity of a Cholinergic and Peptidergic C. elegans Sensory/Inter/Motor Neuron-Type.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Yeon J."/>
                <person name="Choi S.K."/>
                <person name="Huh Y.H."/>
                <person name="Fang Z."/>
                <person name="Park S.J."/>
                <person name="Kim M.O."/>
                <person name="Ryoo Z.Y."/>
                <person name="Kang K."/>
                <person name="Kweon H.S."/>
                <person name="Jeon W.B."/>
                <person name="Li C."/>
                <person name="Kim K."/>
            </authorList>
            <dbReference type="PubMed" id="26305787"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005480"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 284-GLN--ASP-355</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EEA1-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_061066"/>
        </isoform>
        <isoform>
            <id>G5EEA1-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061067"/>
        </isoform>
        <isoform>
            <id>G5EEA1-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001338856.1">
        <property type="nucleotide sequence ID" value="NM_001351879.2"/>
    </dbReference>
    <dbReference type="WormBase" id="ZC64.4b">
        <property type="protein sequence ID" value="CE51976"/>
        <property type="gene ID" value="WBGene00002987"/>
        <property type="gene designation" value="lim-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAB17273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZC64.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZC64.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZC64.4c"/>
        </source>
    </evidence>
    <sequence length="346" mass="38695" checksum="390D14C4D7C7CF33" modified="2011-12-14" version="1">MDAHLVQAKKTSTASELSDSSLTFPFIGDYLSSPSLTTSDYVSDCSNLTVEGPVPANQEFSSSDESSVYISSALRLADYAFTPDDNIRIKPDAVIVICTQCQHQIQDKFFLSIDGRNYHENCLQCSTCENPLSNKCFYKDKTFYCKGCYFRCRELGPKCASCDRTIQATDWVRRARNYVYHLACFSCNQCKRQLSTGEEYALQEGNLLCKQHFLELVEGDSGVSSQKAKTKRVRTTFAEDQLSVLQTYFNRDSNPDGADLEKIASMTGLSKRVTQVWFQNSRARQKKWHQKSEGDNGDSQRSSVGPSSPSQKSDSSSEMMYPTSVTTSVEDAIPDSIVILGSLQFD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>G5EEA1-3</accession>
    <name>LIM4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of LIM/homeobox protein lim-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lim-4</name>
        <name evidence="4" type="ORF">ZC64.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="1999" name="Genes Dev." volume="13" first="1794" last="1806">
            <title>Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4.</title>
            <authorList>
                <person name="Sagasti A."/>
                <person name="Hobert O."/>
                <person name="Troemel E.R."/>
                <person name="Ruvkun G."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="10421632"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ARG-243 AND 284-GLN--ASP-355</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2003" name="Dev. Biol." volume="263" first="81" last="102">
            <title>LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system.</title>
            <authorList>
                <person name="Tsalik E.L."/>
                <person name="Niacaris T."/>
                <person name="Wenick A.S."/>
                <person name="Pau K."/>
                <person name="Avery L."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="14568548"/>
            <dbReference type="DOI" id="10.1016/S0012-1606(03)00447-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 284-GLN--ASP-355</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2005" name="Dev. Biol." volume="286" first="618" last="628">
            <title>Cell-type specific regulation of serotonergic identity by the C. elegans LIM-homeodomain factor LIM-4.</title>
            <authorList>
                <person name="Zheng X."/>
                <person name="Chung S."/>
                <person name="Tanabe T."/>
                <person name="Sze J.Y."/>
            </authorList>
            <dbReference type="PubMed" id="16168406"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2005.08.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 284-GLN--ASP-355</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2015" name="EMBO J." volume="34" first="2574" last="2589">
            <title>Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG-box transcription factor SOX-2.</title>
            <authorList>
                <person name="Alqadah A."/>
                <person name="Hsieh Y.W."/>
                <person name="Vidal B."/>
                <person name="Chang C."/>
                <person name="Hobert O."/>
                <person name="Chuang C.F."/>
            </authorList>
            <dbReference type="PubMed" id="26341465"/>
            <dbReference type="DOI" id="10.15252/embj.201592188"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SOX-2</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="e1005480" last="e1005480">
            <title>The Evolutionarily Conserved LIM Homeodomain Protein LIM-4/LHX6 Specifies the Terminal Identity of a Cholinergic and Peptidergic C. elegans Sensory/Inter/Motor Neuron-Type.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Yeon J."/>
                <person name="Choi S.K."/>
                <person name="Huh Y.H."/>
                <person name="Fang Z."/>
                <person name="Park S.J."/>
                <person name="Kim M.O."/>
                <person name="Ryoo Z.Y."/>
                <person name="Kang K."/>
                <person name="Kweon H.S."/>
                <person name="Jeon W.B."/>
                <person name="Li C."/>
                <person name="Kim K."/>
            </authorList>
            <dbReference type="PubMed" id="26305787"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005480"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 284-GLN--ASP-355</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EEA1-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061067"/>
        </isoform>
        <isoform>
            <id>G5EEA1-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_061066"/>
        </isoform>
        <isoform>
            <id>G5EEA1-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001338857.1">
        <property type="nucleotide sequence ID" value="NM_001351878.2"/>
    </dbReference>
    <dbReference type="WormBase" id="ZC64.4c">
        <property type="protein sequence ID" value="CE52031"/>
        <property type="gene ID" value="WBGene00002987"/>
        <property type="gene designation" value="lim-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAB17273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZC64.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZC64.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZC64.4c"/>
        </source>
    </evidence>
    <sequence length="344" mass="38436" checksum="F6D7AB1E814382EB" modified="2011-12-14" version="1">MDAHLVQAKKTSTASELSDSSLTFPFIGDYLSSPSLTTSDYVSDCSNLTVEGPVPANQEFSSSDESSVYISSALRLADYAFTPDDNIRIKPDAVIVICTQCQHQIQDKFFLSIDGRNYHENCLQCSTCENPLSNKCFYKDKTFYCKGCYFRELGPKCASCDRTIQATDWVRRARNYVYHLACFSCNQCKRQLSTGEEYALQEGNLLCKQHFLELVEGDSGVSSQKAKTKRVRTTFAEDQLSVLQTYFNRDSNPDGADLEKIASMTGLSKRVTQVWFQNSRARQKKWHQKSEGDNGDSQRSSVGPSSPSQKSDSSSEMMYPTSVTTSVEDAIPDSIVILGSLQFD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-05-03" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>G5EGF4-2</accession>
    <name>EGL18_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Putative transcription factor egl-18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Egg laying defective egl-18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Erythroid-like transcription factor family egl-18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">egl-18</name>
        <name evidence="1" type="synonym">elt-5</name>
        <name evidence="6" type="synonym">pvl-3</name>
        <name evidence="6" type="ORF">F55A8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2001" name="Development" volume="128" first="2867" last="2880">
            <title>ELT-5 and ELT-6 are required continuously to regulate epidermal seam cell differentiation and cell fusion in C. elegans.</title>
            <authorList>
                <person name="Koh K."/>
                <person name="Rothman J.H."/>
            </authorList>
            <dbReference type="PubMed" id="11532911"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2002" name="Development" volume="129" first="5171" last="5180">
            <title>Cell fates and fusion in the C. elegans vulval primordium are regulated by the EGL-18 and ELT-6 GATA factors -- apparent direct targets of the LIN-39 Hox protein.</title>
            <authorList>
                <person name="Koh K."/>
                <person name="Peyrot S.M."/>
                <person name="Wood C.G."/>
                <person name="Wagmaister J.A."/>
                <person name="Maduro M.F."/>
                <person name="Eisenmann D.M."/>
                <person name="Rothman J.H."/>
            </authorList>
            <dbReference type="PubMed" id="12399309"/>
            <dbReference type="DOI" id="10.1242/dev.129.22.5171"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 34-LYS--PHE-376; 193-ARG--PHE-376 AND 245-GLN--PHE-376</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2004" name="Dev. Biol." volume="267" first="252" last="263">
            <title>The nT1 translocation separates vulval regulatory elements from the egl-18 and elt-6 GATA factor genes.</title>
            <authorList>
                <person name="Koh K."/>
                <person name="Bernstein Y."/>
                <person name="Sundaram M.V."/>
            </authorList>
            <dbReference type="PubMed" id="14975731"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2003.11.014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 1-358</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2008" name="Cell" volume="134" first="291" last="303">
            <title>An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans.</title>
            <authorList>
                <person name="Budovskaya Y.V."/>
                <person name="Wu K."/>
                <person name="Southworth L.K."/>
                <person name="Jiang M."/>
                <person name="Tedesco P."/>
                <person name="Johnson T.E."/>
                <person name="Kim S.K."/>
            </authorList>
            <dbReference type="PubMed" id="18662544"/>
            <dbReference type="DOI" id="10.1016/j.cell.2008.05.044"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2013" name="Development" volume="140" first="2093" last="2102">
            <title>C. elegans GATA factors EGL-18 and ELT-6 function downstream of Wnt signaling to maintain the progenitor fate during larval asymmetric divisions of the seam cells.</title>
            <authorList>
                <person name="Gorrepati L."/>
                <person name="Thompson K.W."/>
                <person name="Eisenmann D.M."/>
            </authorList>
            <dbReference type="PubMed" id="23633508"/>
            <dbReference type="DOI" id="10.1242/dev.091124"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2014" name="BMC Dev. Biol." volume="14" first="17" last="17">
            <title>Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6.</title>
            <authorList>
                <person name="Liu W.J."/>
                <person name="Reece-Hoyes J.S."/>
                <person name="Walhout A.J."/>
                <person name="Eisenmann D.M."/>
            </authorList>
            <dbReference type="PubMed" id="24885717"/>
            <dbReference type="DOI" id="10.1186/1471-213x-14-17"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 193-ARG--PHE-376 AND 245-GLN--PHE-376</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EGF4-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_061875"/>
        </isoform>
        <isoform>
            <id>G5EGF4-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001294448.1">
        <property type="nucleotide sequence ID" value="NM_001307519.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F55A8.1b">
        <property type="protein sequence ID" value="CE48960"/>
        <property type="gene ID" value="WBGene00001186"/>
        <property type="gene designation" value="egl-18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="11532911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAK32716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAR26006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F55A8.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F55A8.1b"/>
        </source>
    </evidence>
    <sequence length="379" mass="42176" checksum="3D6CDBD5A8546439" modified="2011-12-14" version="1">MSISIMTETRPESAEQQHHEVLQRPSDEPCSGCKQLQKDVAKTISMVMERMDKLQYRLDELLKENNELKSSSVSSGKASPSPAESRSSPKLVETVVAPVSGARKRKPKERSPPAAASPLPDFSNLMNGFMFDPLNMSNPNGMMQLLSMVQQQQQQQQHHQHIENQQSVSPPQSKSVKIEDPMDQDVKQEESERSDIPTATEAQNLLDALTAQFSSNGQAFFQTSTTSPPSSSSQVQAVIEAVATPSSQSQDSSMFEKTETSGDPNAARCSNCRTDKTTAWRRDAEGKLVCNPCGLYYRLHKVRRPIEMRKNHIQQRYRRKNKEKESSAATQIFNQLLTQMPTMATGGVSTDGAINTFNLLEQISQFTQAQELMNSSATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K8F7Y8</accession>
    <name>K8F7Y8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class U</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">sru-26</name>
        <name evidence="2" type="ORF">CELE_T04A11.12</name>
        <name evidence="4" type="ORF">T04A11.12</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCO25656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263799.1">
        <property type="nucleotide sequence ID" value="NM_001276870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K8F7Y8"/>
    <dbReference type="SMR" id="K8F7Y8"/>
    <dbReference type="GeneID" id="266905"/>
    <dbReference type="AGR" id="WB:WBGene00005689"/>
    <dbReference type="CTD" id="266905"/>
    <dbReference type="WormBase" id="T04A11.12b">
        <property type="protein sequence ID" value="CE31723"/>
        <property type="gene ID" value="WBGene00005689"/>
        <property type="gene designation" value="sru-26"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049496_0_0_1"/>
    <dbReference type="OMA" id="NAMIVIC"/>
    <dbReference type="PhylomeDB" id="K8F7Y8"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003839">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sru"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46045:SF16">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS U-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46045">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS U-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10322">
        <property type="entry name" value="7TM_GPCR_Sru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCO25656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T04A11.12b"/>
        </source>
    </evidence>
    <sequence length="327" mass="38234" checksum="B24EBADAB45E0009" modified="2013-02-06" version="1">MFTLPPVLNSSYVGIHGNSTFINFEFSFYTLPMLFLLVPILYIPITIIIILRILVKLYYAFRDRNNNVYLLSAISISQCMCLLFFLADFLYLRLPTSGLLTSWCASIEPNRFITILTIFTYHINYSTMIFPFLVSIMRLILIISPKNHKKFNGQLLRFSIPFICVYPIIFTFFMFPAIGYCSYAAYPFPFGAIIFRIERTFFGLVNNFSLLFNTLFWMTCCIITNFILLLLLIKSRCLLNAQTRSMHSYKVEVSLSLTTFSMIFSYLSNAMIVICSFFFWNYTSLAIMLRPFGNDLDTCVAPWVFYLTHPVFRKKVVQRIFIFRPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>O18197</accession>
    <name>O18197_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Geranylgeranyl transferase type-1 subunit beta</fullName>
            <ecNumber evidence="4">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Geranylgeranyl transferase type I subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CELE_Y48E1B.3</name>
        <name evidence="14 16" type="ORF">Y48E1B.3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="13">
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            <begin position="27"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB07699.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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    </evidence>
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            <dbReference type="PeptideAtlas" id="O18197"/>
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    </evidence>
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            <fullName>Isoform b of Putative polypeptide N-acetylgalactosaminyltransferase 10</fullName>
            <shortName>pp-GaNTase 10</shortName>
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        <alternativeName>
            <fullName>UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10</fullName>
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        <name type="primary">gly-10</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Mol. Biol. Cell" volume="16" first="4202" last="4213">
            <title>The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation.</title>
            <authorList>
                <person name="Wang H."/>
                <person name="Spang A."/>
                <person name="Sullivan M.A."/>
                <person name="Hryhorenko J."/>
                <person name="Hagen F.K."/>
            </authorList>
            <dbReference type="PubMed" id="15987734"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-05-0472"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
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        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-232</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O45947-1</id>
            <name>a</name>
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        <isoform>
            <id>O45947-2</id>
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    <dbReference type="EC" id="2.4.1.41"/>
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    <dbReference type="Proteomes" id="UP000001940">
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    <name>ELT7_CAEEL</name>
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        <recommendedName>
            <fullName evidence="1">Isoform b of Transcription factor elt-7</fullName>
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        <name evidence="3" type="primary">elt-7</name>
        <name evidence="3" type="ORF">C18G1.2</name>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="14086" last="14091">
            <title>A conserved role for a GATA transcription factor in regulating epithelial innate immune responses.</title>
            <authorList>
                <person name="Shapira M."/>
                <person name="Hamlin B.J."/>
                <person name="Rong J."/>
                <person name="Chen K."/>
                <person name="Ronen M."/>
                <person name="Tan M.W."/>
            </authorList>
            <dbReference type="PubMed" id="16968778"/>
            <dbReference type="DOI" id="10.1073/pnas.0603424103"/>
        </citation>
        <scope>INDUCTION BY P.AERUGINOSA</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="379" first="201" last="211">
            <title>Transcription factors GATA/ELT-2 and forkhead/HNF-3/PHA-4 regulate the tropomyosin gene expression in the pharynx and intestine of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Anokye-Danso F."/>
                <person name="Anyanful A."/>
                <person name="Sakube Y."/>
                <person name="Kagawa H."/>
            </authorList>
            <dbReference type="PubMed" id="18448117"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2007.11.103"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2010" name="Dev. Biol." volume="347" first="154" last="166">
            <title>Endoderm development in Caenorhabditis elegans: the synergistic action of ELT-2 and -7 mediates the specification-differentiation transition.</title>
            <authorList>
                <person name="Sommermann E.M."/>
                <person name="Strohmaier K.R."/>
                <person name="Maduro M.F."/>
                <person name="Rothman J.H."/>
            </authorList>
            <dbReference type="PubMed" id="20807527"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.08.020"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2011" name="Dev. Comp. Immunol." volume="35" first="521" last="524">
            <title>Mode of bacterial pathogenesis determines phenotype in elt-2 and elt-7 RNAi Caenorhabditis elegans.</title>
            <authorList>
                <person name="Elliott S.L."/>
                <person name="Sturgeon C.R."/>
                <person name="Travers D.M."/>
                <person name="Montgomery M.C."/>
            </authorList>
            <dbReference type="PubMed" id="21168435"/>
            <dbReference type="DOI" id="10.1016/j.dci.2010.12.008"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2013" name="Development" volume="140" first="4844" last="4849">
            <title>Transdifferentiation and remodeling of post-embryonic C. elegans cells by a single transcription factor.</title>
            <authorList>
                <person name="Riddle M.R."/>
                <person name="Weintraub A."/>
                <person name="Nguyen K.C."/>
                <person name="Hall D.H."/>
                <person name="Rothman J.H."/>
            </authorList>
            <dbReference type="PubMed" id="24257624"/>
            <dbReference type="DOI" id="10.1242/dev.103010"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2016" name="Development" volume="143" first="483" last="491">
            <title>The Function and Regulation of the GATA Factor ELT-2 in the C. elegans Endoderm.</title>
            <authorList>
                <person name="Wiesenfahrt T."/>
                <person name="Berg J.Y."/>
                <person name="Nishimura E.O."/>
                <person name="Robinson A.G."/>
                <person name="Goszczynski B."/>
                <person name="Lieb J.D."/>
                <person name="McGhee J.D."/>
            </authorList>
            <dbReference type="PubMed" id="26700680"/>
            <dbReference type="DOI" id="10.1242/dev.130914"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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            <id>O61924-2</id>
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        <isoform>
            <id>O61924-1</id>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C18G1.2b"/>
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    </evidence>
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    <accession>P13528-2</accession>
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        <recommendedName>
            <fullName>Isoform a of Transcription factor unc-86</fullName>
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        <name type="ORF">C30A5.7</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
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            <dbReference type="PubMed" id="7237544"/>
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        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
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    <reference key="2">
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            <dbReference type="PubMed" id="2903797"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B)</scope>
    </reference>
    <reference key="3">
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        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
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            <title>Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3.</title>
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                <person name="Xue D."/>
                <person name="Finney M."/>
                <person name="Ruvkun G."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="1361171"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
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            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
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            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1998" name="Development" volume="125" first="4107" last="4119">
            <title>Regulation of touch receptor differentiation by the Caenorhabditis elegans mec-3 and unc-86 genes.</title>
            <authorList>
                <person name="Duggan A."/>
                <person name="Ma C."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="9735371"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="7">
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2000" name="EMBO J." volume="19" first="3694" last="3703">
            <title>Protein interaction surface of the POU transcription factor UNC-86 selectively used in touch neurons.</title>
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                <person name="Rohrig S."/>
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                <person name="Donhauser R."/>
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            </authorList>
            <dbReference type="PubMed" id="10899123"/>
            <dbReference type="DOI" id="10.1093/emboj/19.14.3694"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-160 AND LEU-210</scope>
    </reference>
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        <citation type="journal article" date="2002" name="Development" volume="129" first="3901" last="3911">
            <title>The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.</title>
            <authorList>
                <person name="Sze J.Y."/>
                <person name="Zhang S."/>
                <person name="Li J."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="12135927"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2002" name="Genes Dev." volume="16" first="972" last="983">
            <title>Control of neuronal subtype identity by the C. elegans ARID protein CFI-1.</title>
            <authorList>
                <person name="Shaham S."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="11959845"/>
            <dbReference type="DOI" id="10.1101/gad.976002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="9560" last="9565">
            <title>Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity.</title>
            <authorList>
                <person name="Sze J.Y."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="12883006"/>
            <dbReference type="DOI" id="10.1073/pnas.1530752100"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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            <title>MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kage E."/>
                <person name="Hayashi Y."/>
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                <person name="Hirotsu T."/>
                <person name="Kunitomo H."/>
                <person name="Inoue T."/>
                <person name="Arai H."/>
                <person name="Iino Y."/>
                <person name="Kubo T."/>
            </authorList>
            <dbReference type="PubMed" id="16139210"/>
            <dbReference type="DOI" id="10.1016/j.cub.2005.07.057"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2011" name="Dev. Dyn." volume="240" first="1815" last="1825">
            <title>The POU transcription factor UNC-86 controls the timing and ventral guidance of Caenorhabditis elegans axon growth.</title>
            <authorList>
                <person name="Olsson-Carter K."/>
                <person name="Slack F.J."/>
            </authorList>
            <dbReference type="PubMed" id="21656875"/>
            <dbReference type="DOI" id="10.1002/dvdy.22667"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2013" name="Curr. Biol." volume="23" first="1527" last="1535">
            <title>Dauer-specific dendrite arborization in C. elegans is regulated by KPC-1/Furin.</title>
            <authorList>
                <person name="Schroeder N.E."/>
                <person name="Androwski R.J."/>
                <person name="Rashid A."/>
                <person name="Lee H."/>
                <person name="Lee J."/>
                <person name="Barr M.M."/>
            </authorList>
            <dbReference type="PubMed" id="23932402"/>
            <dbReference type="DOI" id="10.1016/j.cub.2013.06.058"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Development" volume="141" first="422" last="435">
            <title>The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.</title>
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                <person name="Zhang F."/>
                <person name="Bhattacharya A."/>
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            <dbReference type="PubMed" id="24353061"/>
            <dbReference type="DOI" id="10.1242/dev.099721"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DNA-BINDING</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="16">
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            <title>A competition mechanism for a homeotic neuron identity transformation in C. elegans.</title>
            <authorList>
                <person name="Gordon P.M."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="26096732"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2015.04.023"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF LEU-210</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P13528-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_002344"/>
        </isoform>
        <isoform>
            <id>P13528-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001309473.1">
        <property type="nucleotide sequence ID" value="NM_001322687.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C30A5.7a">
        <property type="protein sequence ID" value="CE51471"/>
        <property type="gene ID" value="WBGene00006818"/>
        <property type="gene designation" value="unc-86"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
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    <proteinExistence type="evidence at protein level"/>
    <sequence length="301" mass="33769" checksum="9BB741DD37720AB9" modified="2022-10-12" version="2">MRPHDMFSYSNYFSGIHDTSAATNIYQGLPSSSEPFDASVVVPTSSDDQMTPLQQVMAMQQSYGAPPPFQYNMTHPFSTTSIASSNNLARYPIAPPTSDMDTDPRQLETFAEHFKQRRIKLGVTQADVGKALAHLKMPGVGSLSQSTICRFESLTLSHNNMVALKPILHSWLEKAEEAMKQKDTIGDINGILPNTDKKRKRTSIAAPEKRELEQFFKQQPRPSGERIASIADRLDLKKNVVRVWFCNQRQKQKRDFRSQFRARSAAAVMGPRVMPVLNGNNSNNNLKQGQTTYNGLPGFFD</sequence>
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    <accession>P49595-2</accession>
    <name>PPM1G_CAEEL</name>
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        <recommendedName>
            <fullName evidence="2">Isoform b of Protein phosphatase ppm-1.G</fullName>
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            <fullName evidence="2">Protein phosphatase 2C isoform gamma homolog</fullName>
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        <alternativeName>
            <fullName evidence="2">Protein phosphatase magnesium-dependent 1 gamma homolog</fullName>
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    <gene>
        <name evidence="3" type="primary">ppm-1.G</name>
        <name evidence="3" type="ORF">F42G9.1</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P49595-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060334"/>
        </isoform>
        <isoform>
            <id>P49595-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
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    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001359798.1">
        <property type="nucleotide sequence ID" value="NM_001373838.3"/>
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    <dbReference type="WormBase" id="F42G9.1b">
        <property type="protein sequence ID" value="CE30788"/>
        <property type="gene ID" value="WBGene00018362"/>
        <property type="gene designation" value="ppm-1.G"/>
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    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
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            <dbReference type="UniProtKB" id="P35813"/>
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    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F42G9.1a"/>
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    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F42G9.1b"/>
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    </evidence>
    <sequence length="469" mass="50994" checksum="808D01F7752F2C3A" modified="1996-10-01" version="2">MDFKNVEYFYLKNFQDAHNCVVDLHTDWHMFGVYDGHGGTEVSKFTSAKLPDFLKERKFWEADDVAECLQKAFVDFDDFIRAEESMKELKDIGDEGKPKKAGGEADSEDEADRIDTIEEASVPLAELLKRYGGAGVGKSLLSAFLAKGDVSDDSEDEDEDEEEAEEQDDTEEKKENEDASAEVVIENAEDKEEEEGSPKKKGQKRCQKSPIQSEAKKSKSETDAETAPSSSSGVDGVATEEEDEDDSDKEFVADEEEDDEDAEDEQSDEEMVDGSLAPLLLGSGGAEVPGEDSGTTACVCLVGKDKVIVANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQIEDGRVNGGLNLSRAFGDHAYKKNQELGLKEQMITALPDVKIEALTPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGSSCAEVCDALCDACLADSTDGDGTGCDNMTVICTTFDRKSK</sequence>
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    <accession>P52887-2</accession>
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        <recommendedName>
            <fullName evidence="1">Isoform b of Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase</fullName>
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            <fullName>Asparagine-linked glycosylation protein 8 homolog</fullName>
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        <alternativeName>
            <fullName>Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase</fullName>
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        <alternativeName>
            <fullName>Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase</fullName>
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        <name evidence="2" type="ORF">C08H9.3</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P52887-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P52887-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_012308 VSP_012307"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.4.1.265" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001379427.1">
        <property type="nucleotide sequence ID" value="NM_001393171.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C08H9.3b">
        <property type="protein sequence ID" value="CE37608"/>
        <property type="gene ID" value="WBGene00007464"/>
        <property type="gene designation" value="algn-8"/>
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        <property type="component" value="Chromosome II"/>
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            <dbReference type="UniProtKB" id="P40351"/>
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    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="123" mass="14252" checksum="1B2BCB1492090259" modified="2012-10-03" version="3">MGEVQLVLAVTAILISFKCLLIPAYVSTDFEVHRNWMAVTWQRPLCEWYTEATSEWTLDYPPFFAYFELGLASVAHFFGFDECLVISKTPRFSRRILIFQRFSVIFCDILLLSALYTPSALHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>P54815-2</accession>
    <name>MSP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Mitochondrial sorting homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mspn-1</name>
        <name type="ORF">K04D7.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P54815-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P54815-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_000023"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_501861.1">
        <property type="nucleotide sequence ID" value="NM_069460.3"/>
    </dbReference>
    <dbReference type="WormBase" id="K04D7.2b">
        <property type="protein sequence ID" value="CE28241"/>
        <property type="gene ID" value="WBGene00010557"/>
        <property type="gene designation" value="mspn-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="339" mass="37364" checksum="394A75B04254362F" modified="2002-07-11" version="2">MTDRNELIGVAIRVVAAAAVSFLSVRYLVKYLDPNYSVNEESKKKLFHELGIDRQIELSEHEIRIATQFVGGEDVGADWDEIGGCEELVAELKDRIILPLRFASQSGSHLLSPPRGILLYGPPGCGKTLLAKAVARAAGCRFINLQVSNLTDKWYGESQKLAAAVFSVAQKFQPTIIFIDEIDSFLRDRQSHDHESTAMMKAQFMTLWDGFSSSGDQIIVMGATNRPRDVDAAILRRMTARFQVPVPNAKQRSQILNVILRNEKINNTVNLGEIAQAAEGLSGSDLKEVCRLALLARAKATVASGGSVNQLLPLEQSDFESAVHKYMRAAHLLVEETLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="168" xmlns="https://uniprot.org/uniprot">
    <accession>Q10038-2</accession>
    <name>VHP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Tyrosine-protein phosphatase vhp-1</fullName>
            <ecNumber>3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Vh1 dual specificity phosphatase family protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">vhp-1</name>
        <name type="ORF">F08B1.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="EMBO J." volume="23" first="2226" last="2234">
            <title>The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response.</title>
            <authorList>
                <person name="Mizuno T."/>
                <person name="Hisamoto N."/>
                <person name="Terada T."/>
                <person name="Kondo T."/>
                <person name="Adachi M."/>
                <person name="Nishida E."/>
                <person name="Kim D.H."/>
                <person name="Ausubel F.M."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="15116070"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600226"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF CYS-262</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="10738" last="10743">
            <title>Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways.</title>
            <authorList>
                <person name="Nix P."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
                <person name="Bastiani M."/>
            </authorList>
            <dbReference type="PubMed" id="21670305"/>
            <dbReference type="DOI" id="10.1073/pnas.1104830108"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PMK-3</scope>
        <scope>MUTAGENESIS OF CYS-262</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q10038-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q10038-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_014014"/>
        </isoform>
        <isoform>
            <id>Q10038-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_014013 VSP_014015"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48"/>
    <dbReference type="RefSeq" id="NP_494998.1">
        <property type="nucleotide sequence ID" value="NM_062597.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F08B1.1b">
        <property type="protein sequence ID" value="CE27919"/>
        <property type="gene ID" value="WBGene00006923"/>
        <property type="gene designation" value="vhp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="606" mass="64963" checksum="5B71795C6ED58058" modified="2005-06-07" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="168" xmlns="https://uniprot.org/uniprot">
    <accession>Q10038-3</accession>
    <name>VHP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Tyrosine-protein phosphatase vhp-1</fullName>
            <ecNumber>3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Vh1 dual specificity phosphatase family protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">vhp-1</name>
        <name type="ORF">F08B1.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="EMBO J." volume="23" first="2226" last="2234">
            <title>The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response.</title>
            <authorList>
                <person name="Mizuno T."/>
                <person name="Hisamoto N."/>
                <person name="Terada T."/>
                <person name="Kondo T."/>
                <person name="Adachi M."/>
                <person name="Nishida E."/>
                <person name="Kim D.H."/>
                <person name="Ausubel F.M."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="15116070"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600226"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF CYS-262</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="10738" last="10743">
            <title>Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways.</title>
            <authorList>
                <person name="Nix P."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
                <person name="Bastiani M."/>
            </authorList>
            <dbReference type="PubMed" id="21670305"/>
            <dbReference type="DOI" id="10.1073/pnas.1104830108"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PMK-3</scope>
        <scope>MUTAGENESIS OF CYS-262</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q10038-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q10038-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_014013 VSP_014015"/>
        </isoform>
        <isoform>
            <id>Q10038-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_014014"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="439" mass="46893" checksum="A7FF64BDC46B0774" modified="2005-06-07" version="2">MTRLPQSLSQPCLSQPTGDGITLITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIKDHVLDYNQASRPHRHMDYYGPSDLCPPKVPKSASSNCVFPGSTHDESSPSSPSVSEGSAASEPETSSSAASSSSTASAPPSMPSTSEQGTSSGTVNVNGKRNMTMDLGLPHRPKALGLPSRIGTSVAELPSPSTELSRLSFNGPEAIAPSTPILNFTNPCFNSPIIPVASSSREVILTLPTPAASSSSSTSSEPSFDFSSFESSSSSSIVVENPFFASTEVPAGSSSISTPSGSQSTPASASSSAASRCRMKGFFKVFSKKAPASTSTPVSIMKLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q10946-2</accession>
    <name>C19L2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of CWF19-like protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cwf-19L2</name>
        <name evidence="1" type="ORF">B0361.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q10946-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_062481"/>
        </isoform>
        <isoform>
            <id>Q10946-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021126.1">
        <property type="nucleotide sequence ID" value="NM_001025955.5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="B0361.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="B0361.2b"/>
        </source>
    </evidence>
    <sequence length="100" mass="11784" checksum="C613E7D163488861" modified="2003-07-19" version="2">MDNKKLIETKDLRRQIPKGFSYFAVDFGLSNGFAHVIESHDHFPSTFATEIIAGMLDLPPKKWRKRETDEMSKQKSRAENFKKLWEPVDWTKRLKNDSTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="166" xmlns="https://uniprot.org/uniprot">
    <accession>Q11176-2</accession>
    <name>WDR1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Actin-interacting protein 1</fullName>
            <shortName>AIP1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Uncoordinated protein 78</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">unc-78</name>
        <name type="ORF">C04F6.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="J. Cell Biol." volume="152" first="1313" last="1320">
            <title>The Caenorhabditis elegans unc-78 gene encodes a homologue of actin-interacting protein 1 required for organized assembly of muscle actin filaments.</title>
            <authorList>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="11257131"/>
            <dbReference type="DOI" id="10.1083/jcb.152.6.1313"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <source>
            <strain>Bristol N2</strain>
            <tissue>Embryo</tissue>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q11176-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q11176-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020108"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="517" mass="54963" checksum="56541A7CF1F5B64F" modified="1997-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2026-01-28" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>Q17423-4</accession>
    <name>CREC_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform d of Crescerin-like protein che-12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">che-12</name>
        <name evidence="3" type="ORF">B0024.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Genetics" volume="178" first="989" last="1002">
            <title>The conserved proteins CHE-12 and DYF-11 are required for sensory cilium function in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Bacaj T."/>
                <person name="Lu Y."/>
                <person name="Shaham S."/>
            </authorList>
            <dbReference type="PubMed" id="18245347"/>
            <dbReference type="DOI" id="10.1534/genetics.107.082453"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="Mol. Biol. Cell" volume="26" first="4248" last="4264">
            <title>Crescerin uses a TOG domain array to regulate microtubules in the primary cilium.</title>
            <authorList>
                <person name="Das A."/>
                <person name="Dickinson D.J."/>
                <person name="Wood C.C."/>
                <person name="Goldstein B."/>
                <person name="Slep K.C."/>
            </authorList>
            <dbReference type="PubMed" id="26378256"/>
            <dbReference type="DOI" id="10.1091/mbc.E15-08-0603"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF PHE-34; ALA-281; TRP-815 AND TRP-1073</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="G3 (Bethesda)" volume="6" first="1475" last="1487">
            <title>A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Neal S.J."/>
                <person name="Park J."/>
                <person name="DiTirro D."/>
                <person name="Yoon J."/>
                <person name="Shibuya M."/>
                <person name="Choi W."/>
                <person name="Schroeder F.C."/>
                <person name="Butcher R.A."/>
                <person name="Kim K."/>
                <person name="Sengupta P."/>
            </authorList>
            <dbReference type="PubMed" id="26976437"/>
            <dbReference type="DOI" id="10.1534/g3.115.026450"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 645-TRP--ARG-1282</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q17423-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_058557"/>
        </isoform>
        <isoform>
            <id>Q17423-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_058556"/>
        </isoform>
        <isoform>
            <id>Q17423-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q17423-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_058558"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001294732.1">
        <property type="nucleotide sequence ID" value="NM_001307803.4"/>
    </dbReference>
    <dbReference type="WormBase" id="B0024.8d">
        <property type="protein sequence ID" value="CE48310"/>
        <property type="gene ID" value="WBGene00000491"/>
        <property type="gene designation" value="che-12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="18245347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="B0024.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="B0024.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="B0024.8c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="B0024.8d"/>
        </source>
    </evidence>
    <sequence length="599" mass="65811" checksum="A7A6F136E7ABEA67" modified="2008-09-23" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q18408</accession>
    <name>Q18408_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IntraMembrane Protease (IMPAS) family</fullName>
        </submittedName>
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    <gene>
        <name evidence="3 5" type="primary">imp-3</name>
        <name evidence="5" type="ORF">C33H5.11</name>
        <name evidence="3" type="ORF">CELE_C33H5.11</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD66573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34144">
        <property type="entry name" value="T34144"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_501286.2">
        <property type="nucleotide sequence ID" value="NM_068885.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18408"/>
    <dbReference type="MEROPS" id="A22.A07"/>
    <dbReference type="PeptideAtlas" id="Q18408"/>
    <dbReference type="GeneID" id="177565"/>
    <dbReference type="UCSC" id="C33H5.11.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016378"/>
    <dbReference type="CTD" id="177565"/>
    <dbReference type="WormBase" id="C33H5.11a">
        <property type="protein sequence ID" value="CE29696"/>
        <property type="gene ID" value="WBGene00016378"/>
        <property type="gene designation" value="imp-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040348_0_0_1"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016378">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18408">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF35">
        <property type="entry name" value="INTRAMEMBRANE PROTEASE (IMPAS) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD66573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C33H5.11a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q18408"/>
        </source>
    </evidence>
    <sequence length="516" mass="58263" checksum="10B1B49FC4605BE4" modified="2002-03-01" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXS9</accession>
    <name>Q1ZXS9_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">Proteasome activator complex subunit 4 C-terminal domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="ORF">CELE_T28B8.3</name>
        <name evidence="4 6" type="ORF">T28B8.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ85766.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040693.2">
        <property type="nucleotide sequence ID" value="NM_001047228.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXS9"/>
    <dbReference type="SMR" id="Q1ZXS9"/>
    <dbReference type="GeneID" id="189032"/>
    <dbReference type="KEGG" id="cel:CELE_T28B8.3"/>
    <dbReference type="UCSC" id="T28B8.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012114"/>
    <dbReference type="CTD" id="189032"/>
    <dbReference type="WormBase" id="T28B8.3b">
        <property type="protein sequence ID" value="CE42177"/>
        <property type="gene ID" value="WBGene00012114"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238266_0_0_1"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012114">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXS9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001127">
        <property type="entry name" value="Protein CBG03866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF4">
        <property type="entry name" value="DUF3437 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="2">
        <location>
            <begin position="354"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ85766.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="T28B8.3b"/>
        </source>
    </evidence>
    <sequence length="439" mass="50386" checksum="3756983D76FD20D9" modified="2008-03-18" version="2">METILDPTSDLRRVWWLIEGMIDGARMATLANEFQLAFRITSIQSNCWRYGQISKRASDIAWTKLQLALTDSLRNAISEVFYSCSEAREASSNATLINIPSRFIPDSLDTIIHKIIDKIPDLKFMEDQKIIRASLSHLDLNPPTGKMSRRRSSAIDLEDIKVSGMDTIYTRMHNNFQSMTYFRVLLQTITQHYGSSTKSWSPILVKLLPKLMEYANEDDYDLSEETYRDVDITQNSALIIHDYMSVSWISHMFLDEILKALGTTFHSNSWHVRLAVIKFVQAAVYSNIFPMSQQSRRDDIEKLLFRAVYDREISVRKEAAKCLLLFIHCSYIQFSDQKIDKLANILQSETELEARAHGASLALGAFVLAFPFFLPTNIIKPLSLLSSSSSNQAVVKKTMTETVREFRRQHRDDWEETKKILGDALTFDIENTTAPAYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXT0</accession>
    <name>Q1ZXT0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F29C6.1</name>
        <name evidence="2 4" type="ORF">F29C6.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ85774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040661.1">
        <property type="nucleotide sequence ID" value="NM_001047196.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXT0"/>
    <dbReference type="IntAct" id="Q1ZXT0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q1ZXT0"/>
    <dbReference type="GeneID" id="172947"/>
    <dbReference type="KEGG" id="cel:CELE_F29C6.1"/>
    <dbReference type="UCSC" id="F29C6.1b.3">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009243"/>
    <dbReference type="CTD" id="172947"/>
    <dbReference type="WormBase" id="F29C6.1b">
        <property type="protein sequence ID" value="CE40049"/>
        <property type="gene ID" value="WBGene00009243"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108636_0_0_1"/>
    <dbReference type="OrthoDB" id="5849406at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009243">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXT0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ85774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F29C6.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q1ZXT0"/>
        </source>
    </evidence>
    <sequence length="84" mass="9400" checksum="D490F9CBB236B0F3" modified="2006-04-18" version="1">MSHAYAKNFTPVFVKDENGIPFIYIFKETVHADGLIEDQIAGMSLKEKDESKVEDNEEVVEEVKDQPKTSEPAKQEATTEAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXT1</accession>
    <name>Q1ZXT1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">ador-1</name>
        <name evidence="13" type="ORF">CELE_T21B4.4</name>
        <name evidence="15" type="ORF">T21B4.4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAJ85776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040810.1">
        <property type="nucleotide sequence ID" value="NM_001047345.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXT1"/>
    <dbReference type="SMR" id="Q1ZXT1"/>
    <dbReference type="GeneID" id="174890"/>
    <dbReference type="UCSC" id="T21B4.4b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011878"/>
    <dbReference type="CTD" id="174890"/>
    <dbReference type="WormBase" id="T21B4.4b">
        <property type="protein sequence ID" value="CE40127"/>
        <property type="gene ID" value="WBGene00011878"/>
        <property type="gene designation" value="ador-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011878">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXT1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14968">
        <property type="entry name" value="7tmA_Adenosine_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ85776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="T21B4.4b"/>
        </source>
    </evidence>
    <sequence length="360" mass="41721" checksum="1F754D5CD702C14D" modified="2006-04-18" version="1">MDTLLWYAIAELLLSIHISFSNLLVLWVYVRSKHVRTVTNTYIFSLALTDFLAGALGIPLTVVSVMTRKPRTFYGCLFVHLILCILCTISTFHMLAIAIDKYVTICCRDRIFSSRRKRAIFLLTTSWILGLLVAILPLFNVFGFAETQSLFIENGEMCHFTMVVDYRYLVYVIFFSTILAPTAIIVLLYSSIYSRIRTEEKQVKCLLRQSERERRMAGRRKLIRILLILVVSYGICWYPLYIINTIDYFWPEFSINSLTLWTVIMSHMSCALNPLIYAYGMPGFKKALRAFFNIQTDNNTCANYSCYMRSTANQKQRSISVRGMPYETSLAAIRKISAPTPTMLDRHRSRRRQTVDHIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXT5</accession>
    <name>Q1ZXT5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">ncx-4</name>
        <name evidence="10" type="ORF">CELE_F35C12.2</name>
        <name evidence="12" type="ORF">F35C12.2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ85746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040664.1">
        <property type="nucleotide sequence ID" value="NM_001047199.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXT5"/>
    <dbReference type="SMR" id="Q1ZXT5"/>
    <dbReference type="GeneID" id="172834"/>
    <dbReference type="UCSC" id="F35C12.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003569"/>
    <dbReference type="CTD" id="172834"/>
    <dbReference type="WormBase" id="F35C12.2b">
        <property type="protein sequence ID" value="CE40052"/>
        <property type="gene ID" value="WBGene00003569"/>
        <property type="gene designation" value="ncx-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007948_5_1_1"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003569">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXT5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000066">
        <property type="entry name" value="Na/Ca eXchangers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF69">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ85746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F35C12.2b"/>
        </source>
    </evidence>
    <sequence length="154" mass="16766" checksum="B467A4760397713F" modified="2006-04-18" version="1">MVWWANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVCVGLPIPWLLYFLIEYIKHPNEPLSPISVSSKGLLCSVGMLFIMLIVLVFAIFLSGWKMNKIFGILMIVSYVFFCVFSVSLETDKLVCPLNICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-11" modified="2025-10-08" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q688B2</accession>
    <name>Q688B2_CAEEL</name>
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        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
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        <name evidence="25 27" type="primary">unc-77</name>
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        <name evidence="25" type="ORF">CELE_C11D2.6</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD64246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741413.2">
        <property type="nucleotide sequence ID" value="NM_171352.5"/>
    </dbReference>
    <dbReference type="SMR" id="Q688B2"/>
    <dbReference type="PaxDb" id="6239-C11D2.6d"/>
    <dbReference type="GeneID" id="177379"/>
    <dbReference type="UCSC" id="C11D2.6d">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006809"/>
    <dbReference type="CTD" id="177379"/>
    <dbReference type="WormBase" id="C11D2.6d">
        <property type="protein sequence ID" value="CE37196"/>
        <property type="gene ID" value="WBGene00006809"/>
        <property type="gene designation" value="unc-77"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006809">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q688B2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032224">
        <property type="term" value="P:positive regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000089">
        <property type="entry name" value="Four domain-type voltage-gated ion channel alpha-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000080">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000060">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000061">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000066">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000030">
        <property type="entry name" value="sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000032">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000034">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF2">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="924"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1004"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1066"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1180"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1261"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1293"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1333"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1367"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1405"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1490"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="81"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="429"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="930"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="1259"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1693"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1702"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="1718"/>
            <end position="1728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CCD64246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="C11D2.6d"/>
        </source>
    </evidence>
    <sequence length="1861" mass="215056" checksum="08365F29158D1A0E" modified="2004-10-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-11" modified="2025-10-08" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q688B3</accession>
    <name>Q688B3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">unc-77</name>
        <name evidence="27" type="ORF">C11D2.6</name>
        <name evidence="25" type="ORF">CELE_C11D2.6</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD64244.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_068526.5"/>
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    <dbReference type="SMR" id="Q688B3"/>
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        <property type="organism name" value="c. elegans"/>
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        <property type="protein sequence ID" value="CE48883"/>
        <property type="gene ID" value="WBGene00006809"/>
        <property type="gene designation" value="unc-77"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069766at2759"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006809">
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    <sequence length="1767" mass="204997" checksum="8BF89F8BC4373069" modified="2013-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-11" modified="2025-10-08" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q688B4</accession>
    <name>Q688B4_CAEEL</name>
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        <recommendedName>
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        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
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        <name evidence="25 27" type="primary">unc-77</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
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                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
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    </comment>
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            <title>Linking asymmetric cell division to the terminal differentiation program of postmitotic neurons in C. elegans.</title>
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            <title>pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo.</title>
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            <title>ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.</title>
            <authorList>
                <person name="Haynes C.M."/>
                <person name="Petrova K."/>
                <person name="Benedetti C."/>
                <person name="Yang Y."/>
                <person name="Ron D."/>
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        <citation type="journal article" date="2019" name="Elife" volume="8" first="0" last="0">
            <title>SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.</title>
            <authorList>
                <person name="Gao K."/>
                <person name="Li Y."/>
                <person name="Hu S."/>
                <person name="Liu Y."/>
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        <scope>FUNCTION</scope>
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        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="4639" last="4639">
            <title>Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity.</title>
            <authorList>
                <person name="Shao L.W."/>
                <person name="Peng Q."/>
                <person name="Dong M."/>
                <person name="Gao K."/>
                <person name="Li Y."/>
                <person name="Li Y."/>
                <person name="Li C.Y."/>
                <person name="Liu Y."/>
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        <citation type="journal article" date="2020" name="Sci. Adv." volume="6" first="eabb2529" last="eabb2529">
            <title>NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level.</title>
            <authorList>
                <person name="Zhu D."/>
                <person name="Wu X."/>
                <person name="Zhou J."/>
                <person name="Li X."/>
                <person name="Huang X."/>
                <person name="Li J."/>
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                <person name="Wang Y."/>
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            <dbReference type="DOI" id="10.1126/sciadv.abb2529"/>
        </citation>
        <scope>INTERACTION WITH LIN-40</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2022" name="Cell Rep." volume="38" first="110206" last="110206">
            <title>NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Yang R."/>
                <person name="Li Y."/>
                <person name="Wang Y."/>
                <person name="Zhang J."/>
                <person name="Fan Q."/>
                <person name="Tan J."/>
                <person name="Li W."/>
                <person name="Zou X."/>
                <person name="Liang B."/>
            </authorList>
            <dbReference type="PubMed" id="35021096"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2021.110206"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q86MI0-4</id>
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            <sequence type="described" ref="VSP_060958 VSP_060957"/>
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            <sequence type="described" ref="VSP_060957"/>
        </isoform>
        <isoform>
            <id>Q86MI0-1</id>
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        </isoform>
        <isoform>
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            <sequence type="described" ref="VSP_060958"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001338861.1">
        <property type="nucleotide sequence ID" value="NM_001351875.4"/>
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        <property type="gene ID" value="WBGene00022861"/>
        <property type="gene designation" value="dve-1"/>
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        <property type="component" value="Chromosome X"/>
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    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK1193.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK1193.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK1193.5d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZK1193.5e"/>
        </source>
    </evidence>
    <sequence length="465" mass="52501" checksum="A61684BFCDDBB94E" modified="2003-06-01" version="1">MFPMRVIVETVRSQHCLTCSNEGHMITDTYAIVAGTTTLNQLVETVLAALGHSSMSTSARGLIQVNNWKPLPFDQITENLDDTVENLFKDISSHVVLKILSKPSTDSNSVQCISEVKNKLLKAAVNKNPNVLTNVDNQQVKDVINTIIAGDETLLNSEQIGAVNEWLDTLETNEDRRSPTQVQRFNTLYEIPRLDKWFKSDANPSKQKMNNYLSQLNQSPFRKNNSKISYQQICNWFTQKRSSSRTLAPVDLVQVSSAQTAAQLLPGFQLNLLQSLFGEQRQKFDFYDKLDETKIVGGSDSPSPADDEIHSNSDETIQDTLFSINIKPEPEIDSIASSPDMANSMRESLSSTSPKLLSGLDLGAFSTHSSSTNSMQNANSSAARSRLMFDPLTELPVLEKWFEENPHPTWMQIDQYTQCLNNCAYRENYPHISQHNVKIWFKNRRAKCKRLLNGMQEKLEQKVFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-04-07" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>Q86MI0-3</accession>
    <name>DVE1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Homeobox protein dve-1</fullName>
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        <alternativeName>
            <fullName evidence="3">Defective proventriculus homolog protein</fullName>
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    <gene>
        <name evidence="3" type="primary">dve-1</name>
        <name evidence="3" type="ORF">ZK1193.5</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2007" name="Dev. Cell" volume="13" first="467" last="480">
            <title>ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.</title>
            <authorList>
                <person name="Haynes C.M."/>
                <person name="Petrova K."/>
                <person name="Benedetti C."/>
                <person name="Yang Y."/>
                <person name="Ron D."/>
            </authorList>
            <dbReference type="PubMed" id="17925224"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2007.07.016"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH UBL-5</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="0" last="0">
            <title>SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.</title>
            <authorList>
                <person name="Gao K."/>
                <person name="Li Y."/>
                <person name="Hu S."/>
                <person name="Liu Y."/>
            </authorList>
            <dbReference type="PubMed" id="30642431"/>
            <dbReference type="DOI" id="10.7554/elife.41792"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>SUMOYLATION AT 327</scope>
        <scope>MUTAGENESIS OF LYS-327</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="4639" last="4639">
            <title>Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity.</title>
            <authorList>
                <person name="Shao L.W."/>
                <person name="Peng Q."/>
                <person name="Dong M."/>
                <person name="Gao K."/>
                <person name="Li Y."/>
                <person name="Li Y."/>
                <person name="Li C.Y."/>
                <person name="Liu Y."/>
            </authorList>
            <dbReference type="PubMed" id="32934238"/>
            <dbReference type="DOI" id="10.1038/s41467-020-18501-w"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HDA-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2020" name="Sci. Adv." volume="6" first="eabb2529" last="eabb2529">
            <title>NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level.</title>
            <authorList>
                <person name="Zhu D."/>
                <person name="Wu X."/>
                <person name="Zhou J."/>
                <person name="Li X."/>
                <person name="Huang X."/>
                <person name="Li J."/>
                <person name="Wu J."/>
                <person name="Bian Q."/>
                <person name="Wang Y."/>
                <person name="Tian Y."/>
            </authorList>
            <dbReference type="PubMed" id="32789178"/>
            <dbReference type="DOI" id="10.1126/sciadv.abb2529"/>
        </citation>
        <scope>INTERACTION WITH LIN-40</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2022" name="Cell Rep." volume="38" first="110206" last="110206">
            <title>NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Yang R."/>
                <person name="Li Y."/>
                <person name="Wang Y."/>
                <person name="Zhang J."/>
                <person name="Fan Q."/>
                <person name="Tan J."/>
                <person name="Li W."/>
                <person name="Zou X."/>
                <person name="Liang B."/>
            </authorList>
            <dbReference type="PubMed" id="35021096"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2021.110206"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q86MI0-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_060957"/>
        </isoform>
        <isoform>
            <id>Q86MI0-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q86MI0-2</id>
            <name evidence="6">e</name>
            <sequence type="described" ref="VSP_060958"/>
        </isoform>
        <isoform>
            <id>Q86MI0-4</id>
            <name evidence="5">d</name>
            <sequence type="described" ref="VSP_060958 VSP_060957"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001370744.1">
        <property type="nucleotide sequence ID" value="NM_001383518.2"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK1193.5c">
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        <property type="gene ID" value="WBGene00022861"/>
        <property type="gene designation" value="dve-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK1193.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK1193.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK1193.5d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZK1193.5e"/>
        </source>
    </evidence>
    <sequence length="260" mass="29599" checksum="DF12FAC2FFDA9876" modified="2003-06-01" version="1">MNNYLSQLNQSPFRKNNSKISYQQICNWFTQKRSSSRTLAPVDLVQVSSAQTAAQLLPGFQLNLLQSLFGEQRQKFDFYDKLDETKIVGGSDSPSPADDEIHSNSDETIQDTLFSINIKPEPEIDSIASSPDMANSMRESLSSTSPKLLSGLDLGAFSTHSSSTNSMQNANSSVFSAARSRLMFDPLTELPVLEKWFEENPHPTWMQIDQYTQCLNNCAYRENYPHISQHNVKIWFKNRRAKCKRLLNGMQEKLEQKVFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-04-07" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>Q86MI0-4</accession>
    <name>DVE1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of Homeobox protein dve-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Defective proventriculus homolog protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="primary">dve-1</name>
        <name evidence="3" type="ORF">ZK1193.5</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2007" name="Dev. Cell" volume="13" first="467" last="480">
            <title>ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.</title>
            <authorList>
                <person name="Haynes C.M."/>
                <person name="Petrova K."/>
                <person name="Benedetti C."/>
                <person name="Yang Y."/>
                <person name="Ron D."/>
            </authorList>
            <dbReference type="PubMed" id="17925224"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2007.07.016"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH UBL-5</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="0" last="0">
            <title>SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.</title>
            <authorList>
                <person name="Gao K."/>
                <person name="Li Y."/>
                <person name="Hu S."/>
                <person name="Liu Y."/>
            </authorList>
            <dbReference type="PubMed" id="30642431"/>
            <dbReference type="DOI" id="10.7554/elife.41792"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>SUMOYLATION AT 327</scope>
        <scope>MUTAGENESIS OF LYS-327</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="4639" last="4639">
            <title>Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity.</title>
            <authorList>
                <person name="Shao L.W."/>
                <person name="Peng Q."/>
                <person name="Dong M."/>
                <person name="Gao K."/>
                <person name="Li Y."/>
                <person name="Li Y."/>
                <person name="Li C.Y."/>
                <person name="Liu Y."/>
            </authorList>
            <dbReference type="PubMed" id="32934238"/>
            <dbReference type="DOI" id="10.1038/s41467-020-18501-w"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HDA-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2020" name="Sci. Adv." volume="6" first="eabb2529" last="eabb2529">
            <title>NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level.</title>
            <authorList>
                <person name="Zhu D."/>
                <person name="Wu X."/>
                <person name="Zhou J."/>
                <person name="Li X."/>
                <person name="Huang X."/>
                <person name="Li J."/>
                <person name="Wu J."/>
                <person name="Bian Q."/>
                <person name="Wang Y."/>
                <person name="Tian Y."/>
            </authorList>
            <dbReference type="PubMed" id="32789178"/>
            <dbReference type="DOI" id="10.1126/sciadv.abb2529"/>
        </citation>
        <scope>INTERACTION WITH LIN-40</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2022" name="Cell Rep." volume="38" first="110206" last="110206">
            <title>NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Yang R."/>
                <person name="Li Y."/>
                <person name="Wang Y."/>
                <person name="Zhang J."/>
                <person name="Fan Q."/>
                <person name="Tan J."/>
                <person name="Li W."/>
                <person name="Zou X."/>
                <person name="Liang B."/>
            </authorList>
            <dbReference type="PubMed" id="35021096"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2021.110206"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q86MI0-2</id>
            <name evidence="6">e</name>
            <sequence type="described" ref="VSP_060958"/>
        </isoform>
        <isoform>
            <id>Q86MI0-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q86MI0-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_060957"/>
        </isoform>
        <isoform>
            <id>Q86MI0-4</id>
            <name evidence="5">d</name>
            <sequence type="described" ref="VSP_060957 VSP_060958"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001380218.1">
        <property type="nucleotide sequence ID" value="NM_001392715.1"/>
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    <dbReference type="WormBase" id="ZK1193.5d">
        <property type="protein sequence ID" value="CE51993"/>
        <property type="gene ID" value="WBGene00022861"/>
        <property type="gene designation" value="dve-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK1193.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK1193.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK1193.5d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZK1193.5e"/>
        </source>
    </evidence>
    <sequence length="257" mass="29266" checksum="BBAA9E6B410B3014" modified="2003-06-01" version="1">MNNYLSQLNQSPFRKNNSKISYQQICNWFTQKRSSSRTLAPVDLVQVSSAQTAAQLLPGFQLNLLQSLFGEQRQKFDFYDKLDETKIVGGSDSPSPADDEIHSNSDETIQDTLFSINIKPEPEIDSIASSPDMANSMRESLSSTSPKLLSGLDLGAFSTHSSSTNSMQNANSSAARSRLMFDPLTELPVLEKWFEENPHPTWMQIDQYTQCLNNCAYRENYPHISQHNVKIWFKNRRAKCKRLLNGMQEKLEQKVFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q95PZ2-3</accession>
    <name>MICU1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Calcium uptake protein 1 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">micu-1</name>
        <name evidence="2" type="ORF">Y67H2A.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2018" name="Proc. Natl. Acad. Sci. U.S.A." volume="115" first="E7960" last="E7969">
            <title>MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+.</title>
            <authorList>
                <person name="Kamer K.J."/>
                <person name="Sancak Y."/>
                <person name="Fomina Y."/>
                <person name="Meisel J.D."/>
                <person name="Chaudhuri D."/>
                <person name="Grabarek Z."/>
                <person name="Mootha V.K."/>
            </authorList>
            <dbReference type="PubMed" id="30082385"/>
            <dbReference type="DOI" id="10.1073/pnas.1807811115"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2020" name="Curr. Biol." volume="30" first="865" last="876">
            <title>The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics.</title>
            <authorList>
                <person name="Tang N.H."/>
                <person name="Kim K.W."/>
                <person name="Xu S."/>
                <person name="Blazie S.M."/>
                <person name="Yee B.A."/>
                <person name="Yeo G.W."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="31983639"/>
            <dbReference type="DOI" id="10.1016/j.cub.2019.12.061"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95PZ2-1</id>
            <name evidence="2">d</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95PZ2-3</id>
            <name evidence="1">c</name>
            <sequence type="described" ref="VSP_039909 VSP_039910"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001360161.1">
        <property type="nucleotide sequence ID" value="NM_001372949.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y67H2A.4c">
        <property type="protein sequence ID" value="CE47026"/>
        <property type="gene ID" value="WBGene00013462"/>
        <property type="gene designation" value="micu-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="Y67H2A.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="Y67H2A.4d"/>
        </source>
    </evidence>
    <sequence length="142" mass="16252" checksum="F3FF4545B971AE72" modified="2010-10-05" version="2" precursor="true">MLHCSFLRVIPIKNASKRLIIVRSLTSAPAKTSEAEKQQDSLKNIDAGEKYTALGNIRQKKDVFHYTDRASGVGYSHYSSSVYQHRPYIWPPLRKLYHWNYALVIAGMVILMSDFEWLKDQIKSASLPFRPEASQKEVSCSC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QQ2-2</accession>
    <name>TPC13_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Probable trafficking protein particle complex subunit 13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">C56C10.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95QQ2-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_038031"/>
        </isoform>
        <isoform>
            <id>Q95QQ2-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_031802"/>
        </isoform>
        <isoform>
            <id>Q95QQ2-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="WormBase" id="C56C10.7b">
        <property type="protein sequence ID" value="CE02572"/>
        <property type="gene ID" value="WBGene00016964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="417" mass="46864" checksum="CD88A2F959F42A55" modified="2001-12-01" version="1">MADNPASSSSQQLLALRVMRLARPKFAPVDGFSHDPVDPTGFGELLAGKVSEISKESRQDLPIGEYLIAPQMFENIYLGETFTFYVNVVNESEKTVSSVSLKCELQTSTQRVVLPCSVQDATIESSKCEGQVISHEVKEIGQHILICSVNYKTSNGENMYFRKFFKFPVSKPIDVKTKFYSAEVSSNRVLCINVVFFRTMRIKMSTSKPKLKIHQMRICSWKKSSWIQVNIIMLLVSLMSTDEFGDVGKLLKPKDIRQFLFCLTPADVHNTLGYKDLTSIGKLDMSWRTSMGEKGRLQTSALQRIAPGYGDVRLSVEKTPACVDVQKPFEVSCRLYNCSERALDLQLRLEQPSNRHLVFCSPSGVSLGQLPPSQHVDFSLNVFPVTVGIQSISGIRITDTFTKRIYEHDDIAQIFVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QQ2-3</accession>
    <name>TPC13_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Probable trafficking protein particle complex subunit 13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">C56C10.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95QQ2-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_038031"/>
        </isoform>
        <isoform>
            <id>Q95QQ2-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_031802"/>
        </isoform>
        <isoform>
            <id>Q95QQ2-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379835.1">
        <property type="nucleotide sequence ID" value="NM_001393102.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C56C10.7c">
        <property type="protein sequence ID" value="CE42577"/>
        <property type="gene ID" value="WBGene00016964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="243" mass="27535" checksum="4D384699C7FC214A" modified="2001-12-01" version="1">MYFRKFFKFPVSKPIDVKTKFYSAEDNANQDVYLEAQIENTSNANMFLEKVELDPSQHYNVTSIAHEDEFGDVGKLLKPKDIRQFLFCLTPADVHNTLGYKDLTSIGKLDMSWRTSMGEKGRLQTSALQRIAPGYGDVRLSVEKTPACVDVQKPFEVSCRLYNCSERALDLQLRLEQPSNRHLVFCSPSGVSLGQLPPSQHVDFSLNVFPVTVGIQSISGIRITDTFTKRIYEHDDIAQIFVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-11-16" modified="2025-06-18" version="167" xmlns="https://uniprot.org/uniprot">
    <accession>Q9GTD4-2</accession>
    <name>NHR71_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Nuclear hormone receptor family member nhr-71</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nhr-71</name>
        <name type="ORF">K11E4.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="J. Mol. Evol." volume="60" first="577" last="586">
            <title>Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes.</title>
            <authorList>
                <person name="Robinson-Rechavi M."/>
                <person name="Maina C.V."/>
                <person name="Gissendanner C.R."/>
                <person name="Laudet V."/>
                <person name="Sluder A."/>
            </authorList>
            <dbReference type="PubMed" id="15983867"/>
            <dbReference type="DOI" id="10.1007/s00239-004-0175-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9GTD4-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_053633"/>
        </isoform>
        <isoform>
            <id>Q9GTD4-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="582" mass="67080" checksum="E3EA6279D94CC49E" modified="2004-03-15" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N4Z7</accession>
    <name>Q9N4Z7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GHMP kinase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mvk-1</name>
        <name evidence="7" type="ORF">CELE_Y42G9A.4</name>
        <name evidence="9" type="ORF">Y42G9A.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD71154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022866.1">
        <property type="nucleotide sequence ID" value="NM_001027695.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N4Z7"/>
    <dbReference type="SMR" id="Q9N4Z7"/>
    <dbReference type="PeptideAtlas" id="Q9N4Z7"/>
    <dbReference type="GeneID" id="175863"/>
    <dbReference type="KEGG" id="cel:CELE_Y42G9A.4"/>
    <dbReference type="UCSC" id="Y42G9A.4b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021534"/>
    <dbReference type="CTD" id="175863"/>
    <dbReference type="WormBase" id="Y42G9A.4a">
        <property type="protein sequence ID" value="CE29110"/>
        <property type="gene ID" value="WBGene00021534"/>
        <property type="gene designation" value="mvk-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021534">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N4Z7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000154">
        <property type="entry name" value="MeValonate Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000017">
        <property type="entry name" value="MeValonate Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000028">
        <property type="entry name" value="MeValonate Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="6">
        <location>
            <begin position="495"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1988" name="Cell" volume="52" first="311" last="320">
            <title>Identification of genes required for cytoplasmic localization in early C. elegans embryos.</title>
            <authorList>
                <person name="Kemphues K.J."/>
                <person name="Priess J.R."/>
                <person name="Morton D.G."/>
                <person name="Cheng N.S."/>
            </authorList>
            <dbReference type="PubMed" id="3345562"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(88)80024-2"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="4 6" key="2">
        <citation type="journal article" date="1995" name="Cell" volume="81" first="611" last="620">
            <title>par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed.</title>
            <authorList>
                <person name="Guo S."/>
                <person name="Kemphues K.J."/>
            </authorList>
            <dbReference type="PubMed" id="7758115"/>
            <dbReference type="DOI" id="10.1016/0092-8674(95)90082-9"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain evidence="6">Bristol N2</strain>
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    </reference>
    <reference key="3">
        <citation type="submission" date="1995-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Winge P."/>
                <person name="Fleming J.T."/>
                <person name="Goebel V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="Development" volume="127" first="4419" last="4431">
            <title>MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cells.</title>
            <authorList>
                <person name="Berkowitz L.A."/>
                <person name="Strome S."/>
            </authorList>
            <dbReference type="PubMed" id="11003841"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="Dev. Biol." volume="253" first="54" last="65">
            <title>PAR-1 is required for morphogenesis of the Caenorhabditis elegans vulva.</title>
            <authorList>
                <person name="Hurd D.D."/>
                <person name="Kemphues K.J."/>
            </authorList>
            <dbReference type="PubMed" id="12490197"/>
            <dbReference type="DOI" id="10.1006/dbio.2002.0866"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2008" name="Development" volume="135" first="3665" last="3675">
            <title>MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation.</title>
            <authorList>
                <person name="Tenlen J.R."/>
                <person name="Molk J.N."/>
                <person name="London N."/>
                <person name="Page B.D."/>
                <person name="Priess J.R."/>
            </authorList>
            <dbReference type="PubMed" id="18842813"/>
            <dbReference type="DOI" id="10.1242/dev.027060"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2010" name="Development" volume="137" first="93" last="102">
            <title>C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization.</title>
            <authorList>
                <person name="Kim J.S."/>
                <person name="Hung W."/>
                <person name="Narbonne P."/>
                <person name="Roy R."/>
                <person name="Zhen M."/>
            </authorList>
            <dbReference type="PubMed" id="20023164"/>
            <dbReference type="DOI" id="10.1242/dev.041459"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2010" name="Development" volume="137" first="661" last="670">
            <title>Differential requirements for STRAD in LKB1-dependent functions in C. elegans.</title>
            <authorList>
                <person name="Narbonne P."/>
                <person name="Hyenne V."/>
                <person name="Li S."/>
                <person name="Labbe J.C."/>
                <person name="Roy R."/>
            </authorList>
            <dbReference type="PubMed" id="20110331"/>
            <dbReference type="DOI" id="10.1242/dev.042044"/>
        </citation>
        <scope>PHOSPHORYLATION AT THR-325</scope>
    </reference>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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            <strain evidence="2 3">Bristol N2</strain>
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            <title>Identification of a family of animal sphingomyelin synthases.</title>
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            <dbReference type="DOI" id="10.1038/sj.emboj.7600034"/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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    <reference key="2">
        <citation type="journal article" date="2005" name="EMBO J." volume="24" first="2566" last="2578">
            <title>Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans.</title>
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                <person name="Almedom R.B."/>
                <person name="Schedletzky T."/>
                <person name="Anderson S.D."/>
                <person name="Yates J.R. III"/>
                <person name="Schafer W.R."/>
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            <dbReference type="DOI" id="10.1038/sj.emboj.7600741"/>
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    <reference key="3">
        <citation type="journal article" date="2006" name="Nat. Cell Biol." volume="8" first="1143" last="1148">
            <title>Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo.</title>
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                <person name="Watts J.L."/>
                <person name="Corrigan C."/>
                <person name="Edmonds J.W."/>
                <person name="Sztul E."/>
                <person name="Browse J."/>
                <person name="Miller M.A."/>
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            <dbReference type="DOI" id="10.1038/ncb1476"/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <accession>S6FWQ1</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDG24131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293851.1">
        <property type="nucleotide sequence ID" value="NM_001306922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6FWQ1"/>
    <dbReference type="PeptideAtlas" id="S6FWQ1"/>
    <dbReference type="GeneID" id="178413"/>
    <dbReference type="AGR" id="WB:WBGene00012762"/>
    <dbReference type="CTD" id="178413"/>
    <dbReference type="WormBase" id="Y41E3.1d">
        <property type="protein sequence ID" value="CE48481"/>
        <property type="gene ID" value="WBGene00012762"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018076_3_0_1"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012762">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6FWQ1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDG24131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y41E3.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="S6FWQ1"/>
        </source>
    </evidence>
    <sequence length="31" mass="3654" checksum="4F09D1FC16E0A3FF" modified="2013-10-16" version="1">MSHVNKFGDTPHCIIDKNYYLATFCVCYDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>S6FWQ6</accession>
    <name>S6FWQ6_CAEEL</name>
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        <recommendedName>
            <fullName evidence="5 6">DDB1- and CUL4-associated factor 11 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">wdr-23</name>
        <name evidence="8" type="ORF">CELE_D2030.9</name>
        <name evidence="10" type="ORF">D2030.9</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the WD repeat LEC14B family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDG24146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293283.1">
        <property type="nucleotide sequence ID" value="NM_001306354.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6FWQ6"/>
    <dbReference type="SMR" id="S6FWQ6"/>
    <dbReference type="GeneID" id="172518"/>
    <dbReference type="AGR" id="WB:WBGene00008419"/>
    <dbReference type="CTD" id="172518"/>
    <dbReference type="WormBase" id="D2030.9e">
        <property type="protein sequence ID" value="CE48456"/>
        <property type="gene ID" value="WBGene00008419"/>
        <property type="gene designation" value="wdr-23"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014280_3_1_1"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008419">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6FWQ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001891">
        <property type="entry name" value="DDB1-and CUL4-associated factor 11 homolog"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002367">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017399">
        <property type="entry name" value="DCAF11/LEC14B"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_repeat_p23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="234"/>
            <end position="267"/>
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    <feature type="repeat" description="WD" evidence="7">
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            <end position="323"/>
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    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDG24146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="D2030.9e"/>
        </source>
    </evidence>
    <sequence length="490" mass="55814" checksum="56EC3BDADB9E3B3E" modified="2013-10-16" version="1">MTPHEEQQMFEREQHIAFSGRCHIGDPESCTQLRNEINSRCGPRPSTSNNMEFILNRDLQKRGTSISNPRTVARVLNSHLPNQKRRVDRVATKSFCTQYIQNGTKIVVASQDEKIRFYQRNPDKSKYRSKYMKSDELRVDQCGWSILDTAISLNGDLIAYGTWKDAVFVGKLDFTERQNITWFPIDLNGEPGRDHCAVFCVKFSDSSEQIVCGTSQYSIHVFDVEQRRRIRTIVNAHEDDVNSVCFADLGSNLIYSAGDDGLVKVWDKRAWSDGDVEPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDLRKFSNMSGVSQHWDYRWQPAPPGLCQPVAGDTSVMTLRGHSVLHTLVRANFSPESTGRRYIYTGCARGEVVVYDIMSGTVSRRLKGHTAVVRECDWHPTENEIVSSAWDGVTTVWTWDERQEGVIAPYDHPNISQFGDEDSCDELFQPVKKQCRRQRKTMSSRGHPCSSSSISQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBA1</accession>
    <name>U4PBA1_CAEEL</name>
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        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">pac-1</name>
        <name evidence="7" type="ORF">C04D8.1</name>
        <name evidence="5" type="ORF">CELE_C04D8.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDH93127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293654.1">
        <property type="nucleotide sequence ID" value="NM_001306725.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBA1"/>
    <dbReference type="SMR" id="U4PBA1"/>
    <dbReference type="GeneID" id="176201"/>
    <dbReference type="AGR" id="WB:WBGene00015418"/>
    <dbReference type="CTD" id="176201"/>
    <dbReference type="WormBase" id="C04D8.1d">
        <property type="protein sequence ID" value="CE48933"/>
        <property type="gene ID" value="WBGene00015418"/>
        <property type="gene designation" value="pac-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003398_0_0_1"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015418">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBA1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01253">
        <property type="entry name" value="PH_ARHGAP21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04395">
        <property type="entry name" value="RhoGAP_ARHGAP21"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTPase-activating protein pac-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF133">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN PAC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="132"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="481"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="92"/>
        </location>
    </feature>
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        <location>
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            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="971"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="834"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="971"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C04D8.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBA1"/>
        </source>
    </evidence>
    <sequence length="1138" mass="123570" checksum="ABA65698627CF1E9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBA4</accession>
    <name>U4PBA4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Nonsense-mediated mRNA decay factor SMG8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">smg-8</name>
        <name evidence="6" type="ORF">CELE_K04B12.3</name>
        <name evidence="8" type="ORF">K04B12.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SMG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293560.1">
        <property type="nucleotide sequence ID" value="NM_001306631.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBA4"/>
    <dbReference type="SMR" id="U4PBA4"/>
    <dbReference type="PeptideAtlas" id="U4PBA4"/>
    <dbReference type="GeneID" id="175103"/>
    <dbReference type="AGR" id="WB:WBGene00010551"/>
    <dbReference type="CTD" id="175103"/>
    <dbReference type="WormBase" id="K04B12.3c">
        <property type="protein sequence ID" value="CE49007"/>
        <property type="gene ID" value="WBGene00010551"/>
        <property type="gene designation" value="smg-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375675_0_0_1"/>
    <dbReference type="OrthoDB" id="63589at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010551">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBA4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091">
        <property type="entry name" value="AMPLIFIED IN BREAST CANCER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 4" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH93132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="K04B12.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBA4"/>
        </source>
    </evidence>
    <sequence length="355" mass="39957" checksum="E7C8314062DCBACE" modified="2013-12-11" version="1">MWADRESNSLRAAKKMAQREDELAEEDTDLDIPESLLDPDSTSPSDEDDVRVRTMSSSESSSQESDAYLRPTSRRDESMASKTERELTIDHVKRMQKLELAGKSEDFLITVPNSMTTGKLPIFPSWHLTSLGDSSIYSHGAGLKNQPNFKIGGDYLSPVVVLLDVNFDVWNRDLNKIRSEDFSRKCGKDNKDDSARVKLFVGFEYECSRGHRFFVDYNGEPLIYSKGSNVIRESAHRSSLGNVLQADLPIRRPCTCRKLPLQSAQLQKVHVVTPKAPVHITIDPKVLIPTHEGVYGTGQEPLELHHSKYYILHLPTVYSGPSGAWMPGEFNPEKQGVWMGGALKVAYKPVMSFKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBA6</accession>
    <name>U4PBA6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SEP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">ubxn-2</name>
        <name evidence="3" type="ORF">CELE_Y94H6A.9</name>
        <name evidence="5" type="ORF">Y94H6A.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360209.1">
        <property type="nucleotide sequence ID" value="NM_001372754.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBA6"/>
    <dbReference type="PeptideAtlas" id="U4PBA6"/>
    <dbReference type="GeneID" id="177057"/>
    <dbReference type="AGR" id="WB:WBGene00022381"/>
    <dbReference type="CTD" id="177057"/>
    <dbReference type="WormBase" id="Y94H6A.9d">
        <property type="protein sequence ID" value="CE48955"/>
        <property type="gene ID" value="WBGene00022381"/>
        <property type="gene designation" value="ubxn-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022381">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBA6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="2">
        <location>
            <begin position="89"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y94H6A.9d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBA6"/>
        </source>
    </evidence>
    <sequence length="246" mass="26261" checksum="CC2EE24E3A6DB09B" modified="2013-12-11" version="1">MSRNIRTFRDIGNNDDGGPDSDDSGADAAERGAPQEFYAGSGQAVQGPRGAAARGPDSEAHIRRILQAAEVVQPEGGEAPRGRPSGRETISLTLHLWSDGLSIEDGPLMSRQDPRTIEFLESVGKGEIPPSLVQQYPGKEIDFKVNRHHEEYVAPKMKPFGGSGVRLGNVVPTVLGQSSSSATTAGTSSATTDHNPDHTAENEAKQLEDAKKELSTNMNEPTTNVRSLYYGFGAAKIFGNLEENCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBB4</accession>
    <name>U4PBB4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">unc-49</name>
        <name evidence="5" type="ORF">CELE_T21C12.1</name>
        <name evidence="7" type="ORF">T21C12.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDH93142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370908.1">
        <property type="nucleotide sequence ID" value="NM_001382981.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBB4"/>
    <dbReference type="SMR" id="U4PBB4"/>
    <dbReference type="GeneID" id="176472"/>
    <dbReference type="AGR" id="WB:WBGene00006784"/>
    <dbReference type="CTD" id="176472"/>
    <dbReference type="WormBase" id="T21C12.1j">
        <property type="protein sequence ID" value="CE48604"/>
        <property type="gene ID" value="WBGene00006784"/>
        <property type="gene designation" value="unc-49"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010920_0_2_1"/>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006784">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBB4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000154">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022253064" evidence="3">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="36"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="T21C12.1j"/>
        </source>
    </evidence>
    <sequence length="187" mass="21386" checksum="D0E165B51171A96F" modified="2013-12-11" version="1">MARPFTLIVLLSAHLCLHVVVTQDEDSHINTQLLSSVLDRLTNRTTYDKRLRPRYGEKPVDVGITIHVSSISAVSEVDMDFTLDFYMRQTWQDPRLAFGSLDLGLSKEIDSLTVGVDYLDRLWKPDTFFPNEKKSFFHLATTHNSFLRIEGDGTVYTSQRLTVTATCPMDLKLFPMDSQHCKLEIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBB7</accession>
    <name>U4PBB7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">kvs-5</name>
        <name evidence="18" type="ORF">CELE_Y55F3C.3</name>
        <name evidence="20" type="ORF">Y55F3C.3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294325.1">
        <property type="nucleotide sequence ID" value="NM_001307396.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBB7"/>
    <dbReference type="SMR" id="U4PBB7"/>
    <dbReference type="GeneID" id="176899"/>
    <dbReference type="AGR" id="WB:WBGene00021948"/>
    <dbReference type="CTD" id="176899"/>
    <dbReference type="WormBase" id="Y55F3C.3g">
        <property type="protein sequence ID" value="CE48607"/>
        <property type="gene ID" value="WBGene00021948"/>
        <property type="gene designation" value="kvs-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011722_4_1_1"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021948">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBB7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000070">
        <property type="entry name" value="K+ channel tetramerization domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF114">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004653475" evidence="15">
        <location>
            <begin position="17"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="17">
        <location>
            <begin position="76"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="224"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDH93032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="Y55F3C.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBB7"/>
        </source>
    </evidence>
    <sequence length="511" mass="58262" checksum="8CF9E9FADF995FFB" modified="2013-12-11" version="1">MALLIAPVVAAQIASGSTSMAACERENSVDNQPDRASIDDRSSNKNYDEDVESRMIPVDRPSHKGSIRDNTPDSILRLNIGGSSYRIRTRSIIKFGPKTLLGRFVRMNHEHRRQWADWYFEEQDEYFFERVPRYFDPIYDFYATGKLHVPKDLCFDKFMAELRFWAVSKSRMDECCSPFTQYCVTMGGDPKCTEKDHFIGVRCANIRRRLWLILEGHSQSKWWKAFEIISTAFVVLSISALILGSIPEFQVPQKSEDGQLVYATATYPTYPNGGGMTIESRTVVREGSDNSIEMTEHPVFTWVENVCVIYFSIEYAMRFIVAPRKLAFARQILNVIDLLSIAPFYFELLLWICGISGENVRKVRWAFLTVRLLRVLRVIRIAKLGRFSPGLANFALTIRKSKKQMQMVGVVMMTVIIFFSTLIYFLERDEPGTKFTSIPATFWWCVVTMATVGYGDLVPVTVAGKLVGSGAIVCGVMVLALPITIMVNNFMQVVKLREEEIVKKYAQGDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBC0</accession>
    <name>U4PBC0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">unc-49</name>
        <name evidence="14" type="ORF">CELE_T21C12.1</name>
        <name evidence="16" type="ORF">T21C12.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDH93147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293663.1">
        <property type="nucleotide sequence ID" value="NM_001306734.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBC0"/>
    <dbReference type="SMR" id="U4PBC0"/>
    <dbReference type="GeneID" id="176472"/>
    <dbReference type="AGR" id="WB:WBGene00006784"/>
    <dbReference type="CTD" id="176472"/>
    <dbReference type="WormBase" id="T21C12.1o">
        <property type="protein sequence ID" value="CE48837"/>
        <property type="gene ID" value="WBGene00006784"/>
        <property type="gene designation" value="unc-49"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010920_3_1_1"/>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006784">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBC0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000074">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="94"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDH93147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="T21C12.1o"/>
        </source>
    </evidence>
    <sequence length="280" mass="32032" checksum="6CA473BE88F0C440" modified="2013-12-11" version="1">MDLKLFPMDSQHCKLEIESYAYSTAEIEYKWCTSKEPNCSTAVKADANIELSSYKFTKICQKRTLASTSSGTYSRLRVSFIFDRDSGFYFLQIFFPASLVVVLSWISFWINRDSAPSRTLIGTMTVLTETHLMTGTNRRLPPVAYVKAVDVFLGFCYLLVILALIEYACVAYSKKKNEDRRRREKKTEHKPAPPTPDILHDVRLAECTCNAAPTSIIAVIKQSNRFCVSHSHIDIVSRAAFPLVFILFNTLFWLILLYKSKRLPYISEHEGDRCDAPDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBC2</accession>
    <name>U4PBC2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_F19C7.8</name>
        <name evidence="10 12" type="ORF">F19C7.8</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294329.1">
        <property type="nucleotide sequence ID" value="NM_001307400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBC2"/>
    <dbReference type="SMR" id="U4PBC2"/>
    <dbReference type="GeneID" id="177226"/>
    <dbReference type="KEGG" id="cel:CELE_F19C7.8"/>
    <dbReference type="AGR" id="WB:WBGene00017597"/>
    <dbReference type="CTD" id="177226"/>
    <dbReference type="WormBase" id="F19C7.8d">
        <property type="protein sequence ID" value="CE48506"/>
        <property type="gene ID" value="WBGene00017597"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017597">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBC2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059031">
        <property type="entry name" value="SH3_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
        <property type="entry name" value="STAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF7">
        <property type="entry name" value="STAC-LIKE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26085">
        <property type="entry name" value="SH3_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="STAC3-related SH3" evidence="9">
        <location>
            <begin position="271"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDH93038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F19C7.8d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBC2"/>
        </source>
    </evidence>
    <sequence length="328" mass="36289" checksum="63747C08BBE8F616" modified="2013-12-11" version="1">MSTNSSIESSPIEQATSRSARRKWHSAMRFIQGVQRFKTPVMSHKRTTEIREQSVGRTSCESAIVDPVYLALKQATGRYSRRGSTTFESASPSPRNLSQVSLQDSGYVEMGSSKANPLLGSTPQLDNAGRSVGRRRAPKLTQQMKSLSLDCQDMPPRINQNTRSPLISGSKLAPRDYRKPGINGSSDFSDVERSCSPIVKSRRSSSSALHAGGYIVIHEYSPSNGSSLVLGEKVRVVDNGDPDWLHGFRLNDRTEHMISFPATCVAQMMAGEQAMRIQQNVFVAEQKLRMYRDQIVFVQPESLVEGKVTVRTEHNALAPCPLSYLALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBC3</accession>
    <name>U4PBC3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SPRY domain-containing SOCS box protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">spsb-1</name>
        <name evidence="5" type="ORF">CELE_Y46E12BL.4</name>
        <name evidence="7" type="ORF">Y46E12BL.4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380140.1">
        <property type="nucleotide sequence ID" value="NM_001393241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBC3"/>
    <dbReference type="SMR" id="U4PBC3"/>
    <dbReference type="GeneID" id="266876"/>
    <dbReference type="AGR" id="WB:WBGene00021597"/>
    <dbReference type="CTD" id="266876"/>
    <dbReference type="WormBase" id="Y46E12BL.4c">
        <property type="protein sequence ID" value="CE48635"/>
        <property type="gene ID" value="WBGene00021597"/>
        <property type="gene designation" value="spsb-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5547302at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021597">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBC3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd03718">
        <property type="entry name" value="SOCS_SSB1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000035">
        <property type="entry name" value="SplA/ryanodine receptor domain and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="226"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="412"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y46E12BL.4c"/>
        </source>
    </evidence>
    <sequence length="465" mass="52508" checksum="DAA49745A309602A" modified="2013-12-11" version="1">MSRDEISISTRLKSLRPRRADSISLLQSSNFKLDTTPPPPPQNPLKRCQQDNPKLLIHDQKRRRSVVDAPPPTPESSSVLSQPPIPEDLVSRLSEEILQSIFYLAQSRSGNGHEFTTNVHALLWQYYLNEYVSPSSDACSTSSSTYARPAAAAHSAGNNSSSSSSNAGGGDGYHRSNSSGSSTRPVAATRERKSYAVAAGRSAPMRSLSPAHPSAVMSGMDDFLRPDRFDRIMQMTKPDQFIQEQHSWNPEDRSLNIFVKDEDKFTFHRHPVAQSTDCIRGKMGYSRGFHVWQIEWPERQRGTHAVVGVATKNAPLHAAGYTALIGTTDESYGWDITRRECHHDSKHTMTWRYPFSNSRDVYNVPDKFYCILDMDEGYMAFATDDEFLGVAFRNLKGKTLYPIVAAVWGHCEISMRYLGSLEPEPLSLSELCRRRVRIEMGAQPEDHIEQLMIPPILKRYLMYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBC8</accession>
    <name>U4PBC8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SPRY domain-containing SOCS box protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">spsb-1</name>
        <name evidence="5" type="ORF">CELE_Y46E12BL.4</name>
        <name evidence="7" type="ORF">Y46E12BL.4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368256.1">
        <property type="nucleotide sequence ID" value="NM_001381674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBC8"/>
    <dbReference type="SMR" id="U4PBC8"/>
    <dbReference type="GeneID" id="266876"/>
    <dbReference type="AGR" id="WB:WBGene00021597"/>
    <dbReference type="CTD" id="266876"/>
    <dbReference type="WormBase" id="Y46E12BL.4f">
        <property type="protein sequence ID" value="CE48724"/>
        <property type="gene ID" value="WBGene00021597"/>
        <property type="gene designation" value="spsb-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5547302at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021597">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBC8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd03718">
        <property type="entry name" value="SOCS_SSB1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000035">
        <property type="entry name" value="SplA/ryanodine receptor domain and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="111"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="297"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y46E12BL.4f"/>
        </source>
    </evidence>
    <sequence length="350" mass="39365" checksum="E738E7A54C07EF1C" modified="2013-12-11" version="1">MMGARQSTTSHHDTFQVSPSSDACSTSSSTYARPAAAAHSAGNNSSSSSSNAGGGDGYHRSNSSGSSTRPVAATRERKSYAVAAGRSAPMRSLSPAHPSAVMSGMDDFLRPDRFDRIMQMTKPDQFIQEQHSWNPEDRSLNIFVKDEDKFTFHRHPVAQSTDCIRGKMGYSRGFHVWQIEWPERQRGTHAVVGVATKNAPLHAAGYTALIGTTDESYGWDITRRECHHDSKHTMTWRYPFSNSRDVYNVPDKFYCILDMDEGYMAFATDDEFLGVAFRNLKGKTLYPIVAAVWGHCEISMRYLGSLEPEPLSLSELCRRRVRIEMGAQPEDHIEQLMIPPILKRYLMYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBD1</accession>
    <name>U4PBD1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">cdh-8</name>
        <name evidence="12" type="ORF">CELE_F18F11.3</name>
        <name evidence="14" type="ORF">F18F11.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294410.1">
        <property type="nucleotide sequence ID" value="NM_001307481.3"/>
    </dbReference>
    <dbReference type="GeneID" id="184652"/>
    <dbReference type="AGR" id="WB:WBGene00017576"/>
    <dbReference type="CTD" id="184652"/>
    <dbReference type="WormBase" id="F18F11.3b">
        <property type="protein sequence ID" value="CE48922"/>
        <property type="gene ID" value="WBGene00017576"/>
        <property type="gene designation" value="cdh-8"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799622at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017576">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBD1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004653300" evidence="10">
        <location>
            <begin position="23"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1502"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="54"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="126"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="454"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="549"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="779"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="893"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1174"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1300"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1564"/>
            <end position="1588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDH93162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F18F11.3b"/>
        </source>
    </evidence>
    <sequence length="1588" mass="174979" checksum="7A048DDC810D29CC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBD6</accession>
    <name>U4PBD6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">cdh-8</name>
        <name evidence="12" type="ORF">CELE_F18F11.3</name>
        <name evidence="14" type="ORF">F18F11.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
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            <begin position="54"/>
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            <begin position="126"/>
            <end position="237"/>
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            <end position="548"/>
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        </source>
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        <source>
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            <dbReference type="PROSITE" id="PS50268"/>
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            <dbReference type="EMBL" id="CDH93167.1"/>
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            <dbReference type="WormBase" id="F18F11.3g"/>
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    <sequence length="1604" mass="176969" checksum="37E7DDDAD9A57DDB" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.</text>
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        <property type="gene designation" value="dpy-9"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF420">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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            <end position="32"/>
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            <begin position="11"/>
            <end position="61"/>
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    </feature>
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    </feature>
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            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011518"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDH93043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="T21D12.2b"/>
        </source>
    </evidence>
    <sequence length="210" mass="22048" checksum="07E0BAA3F6360A54" modified="2013-12-11" version="1">MEPSNIWRTSTIVGSVVSTFAVLTVIIGLPLMHNHVQKVTTLMLTEVELCKTESQDIWKQMKFSRMAPNRTKRQSPYGNYGASGSGSCCACTQGSPGPRGQPGDDGEPGRDGFPGREGDNGIAGKYLPAPPPGTNACQKCPTGAPGPPGLPGPQGPKGEPGNPGTCHHCQNRAPAPSEAPGKAPPPPQDYTRPAPESYPSAPNGQYLWIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBE2</accession>
    <name>U4PBE2_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">par-3</name>
        <name evidence="3" type="ORF">CELE_F54E7.3</name>
        <name evidence="5" type="ORF">F54E7.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDH93172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360234.1">
        <property type="nucleotide sequence ID" value="NM_001372593.2"/>
    </dbReference>
    <dbReference type="SMR" id="U4PBE2"/>
    <dbReference type="GeneID" id="175783"/>
    <dbReference type="AGR" id="WB:WBGene00003918"/>
    <dbReference type="CTD" id="175783"/>
    <dbReference type="WormBase" id="F54E7.3f">
        <property type="protein sequence ID" value="CE49038"/>
        <property type="gene ID" value="WBGene00003918"/>
        <property type="gene designation" value="par-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264899at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003918">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBE2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd23059">
        <property type="entry name" value="PDZ3_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000272">
        <property type="entry name" value="Partitioning defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000290">
        <property type="entry name" value="Partitioning defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000291">
        <property type="entry name" value="Partitioning defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF17">
        <property type="entry name" value="BAZOOKA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="302"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="436"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
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        <location>
            <begin position="815"/>
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        <location>
            <begin position="888"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="948"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F54E7.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBE2"/>
        </source>
    </evidence>
    <sequence length="1297" mass="140598" checksum="A11526EE5521C7FC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBE6</accession>
    <name>U4PBE6_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7 9" type="primary">par-3</name>
        <name evidence="7" type="ORF">CELE_F54E7.3</name>
        <name evidence="9" type="ORF">F54E7.3</name>
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    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">Bristol N2</strain>
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        <text evidence="1">Belongs to the PAR3 family.</text>
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    <dbReference type="EMBL" id="BX284603">
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        <property type="nucleotide sequence ID" value="NM_001379719.1"/>
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    <dbReference type="AGR" id="WB:WBGene00003918"/>
    <dbReference type="CTD" id="175783"/>
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        <property type="gene ID" value="WBGene00003918"/>
        <property type="gene designation" value="par-3"/>
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    <dbReference type="HOGENOM" id="CLU_261540_0_0_1"/>
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        <property type="component" value="Chromosome III"/>
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    </dbReference>
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    <dbReference type="Pfam" id="PF12053">
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        <property type="match status" value="3"/>
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        <property type="match status" value="3"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005358"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDH93177.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="F54E7.3k"/>
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    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBE6"/>
        </source>
    </evidence>
    <sequence length="1330" mass="144089" checksum="549B6589E1520291" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBF4</accession>
    <name>U4PBF4_CAEEL</name>
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        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="10 12" type="primary">pde-3</name>
        <name evidence="10" type="ORF">CELE_E01F3.1</name>
        <name evidence="12" type="ORF">E01F3.1</name>
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    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293572.1">
        <property type="nucleotide sequence ID" value="NM_001306643.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBF4"/>
    <dbReference type="SMR" id="U4PBF4"/>
    <dbReference type="GeneID" id="183981"/>
    <dbReference type="AGR" id="WB:WBGene00008443"/>
    <dbReference type="CTD" id="183981"/>
    <dbReference type="WormBase" id="E01F3.1j">
        <property type="protein sequence ID" value="CE48988"/>
        <property type="gene ID" value="WBGene00008443"/>
        <property type="gene designation" value="pde-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008443">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBF4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000018">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
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    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="228"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="303"/>
        </location>
    </feature>
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        <location>
            <begin position="303"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
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        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
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        <location>
            <position position="369"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
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            <position position="369"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="478"/>
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        <ligand>
            <name>AMP</name>
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        <ligand>
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            <label>1</label>
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        <location>
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        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDH93187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="E01F3.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBF4"/>
        </source>
    </evidence>
    <sequence length="640" mass="71554" checksum="82A5D7CD7BA6300E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4PSA6</accession>
    <name>U4PSA6_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">DUF4158 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y37E11B.7</name>
        <name evidence="2 4" type="ORF">Y37E11B.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294648.1">
        <property type="nucleotide sequence ID" value="NM_001307719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PSA6"/>
    <dbReference type="GeneID" id="177121"/>
    <dbReference type="KEGG" id="cel:CELE_Y37E11B.7"/>
    <dbReference type="AGR" id="WB:WBGene00021379"/>
    <dbReference type="CTD" id="177121"/>
    <dbReference type="WormBase" id="Y37E11B.7b">
        <property type="protein sequence ID" value="CE48579"/>
        <property type="gene ID" value="WBGene00021379"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2239024_0_0_1"/>
    <dbReference type="OrthoDB" id="5802199at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021379">
        <property type="expression patterns" value="Expressed in material anatomical entity and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PSA6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y37E11B.7b"/>
        </source>
    </evidence>
    <sequence length="86" mass="9543" checksum="E932135C58EA4A9C" modified="2013-12-11" version="1">MLGLTRGSRVGAADDDPPYFPEEDDFPRARSRVPTYEQAIGTVAGKALPARRWEELEPTHRQILGAPLRRRPLISRVLGRGGGLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>U4PSB4</accession>
    <name>U4PSB4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Inward rectifier potassium channel irk-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">irk-2</name>
        <name evidence="16" type="ORF">CELE_M02A10.2</name>
        <name evidence="18" type="ORF">M02A10.2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDH93480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294850.1">
        <property type="nucleotide sequence ID" value="NM_001307921.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PSB4"/>
    <dbReference type="SMR" id="U4PSB4"/>
    <dbReference type="GeneID" id="191695"/>
    <dbReference type="AGR" id="WB:WBGene00002150"/>
    <dbReference type="CTD" id="191695"/>
    <dbReference type="WormBase" id="M02A10.2d">
        <property type="protein sequence ID" value="CE49005"/>
        <property type="gene ID" value="WBGene00002150"/>
        <property type="gene designation" value="irk-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022738_7_3_1"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002150">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PSB4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000230">
        <property type="entry name" value="Inward Rectifying K (Potassium) channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="33"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="180"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDH93480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="M02A10.2d"/>
        </source>
    </evidence>
    <sequence length="460" mass="52916" checksum="4FE49C7683344C9F" modified="2013-12-11" version="1">MLDIEEPLVKNKKYPFFKTPRLGGSRRIRNRLVQKQGLCNISLKNVPKQRRKYFSDIFTTVIEMKWRWCLLYFSLSFMISWSFFATVYFLIAKQHGDIEQIANATWTPCIVNVHNELNAFLFSFTTQTTIGYGFRYPTDACPLTIVTMCFQFMWGVMTQTLMAGIIFSKLARPIKRAATLIFSKNAVICLRDGKLCLLFRVGDMRKSSLAEAHVRLQMIKRCVTYEGELLPFHQFDMDVGYDQGLDRVFVIWPITICHEIDERSPLWEIGADDLKSAKFEIIAILEGVVESVGSTTQARTSYLPSEILWGHRFEKLVHYKKENGQYNIDFGKFHNVYSVNTPTCSAAEIERLRSEGIFNESEYQMYPPSDNKLNLLDNDEMSPVRDSIDLNQIQILRRDSDEDPDAGEESMELVDLGIHHKCSIRSQSPIINSTSHLLQPMHKNSCSVRRGMLAPPASHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKA7</accession>
    <name>V6CKA7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C17H12.6</name>
        <name evidence="3" type="ORF">CELE_C17H12.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293764.1">
        <property type="nucleotide sequence ID" value="NM_001306835.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKA7"/>
    <dbReference type="SMR" id="V6CKA7"/>
    <dbReference type="GeneID" id="182755"/>
    <dbReference type="AGR" id="WB:WBGene00015932"/>
    <dbReference type="CTD" id="182755"/>
    <dbReference type="WormBase" id="C17H12.6b">
        <property type="protein sequence ID" value="CE49433"/>
        <property type="gene ID" value="WBGene00015932"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1442304_0_0_1"/>
    <dbReference type="OrthoDB" id="5817028at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015932">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKA7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003366">
        <property type="entry name" value="CUB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21447:SF9">
        <property type="entry name" value="CUB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21447">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02408">
        <property type="entry name" value="CUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004746071" evidence="1">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CUB-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C17H12.6b"/>
        </source>
    </evidence>
    <sequence length="188" mass="20910" checksum="BC2DF917BC7AB7BA" modified="2014-02-19" version="1">MIYSSTMSATPLIISLGLLVGVTAALDCTQIPNNAIIPLSYTTIPAGATGLVEIPPNFNCVYNVKVPKMVYARVRLENGLKGYNDLITVQDQQGTYTRVSSRSPSVLNFYVFPNTTTTFQVVTKSVDMHSSFRMIVFYQPMYTETVTHLGNPDMKYFMLNDLQENSYKTPQTIISNEKVRDTSAPEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKB8</accession>
    <name>V6CKB8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ztf-3</name>
        <name evidence="13" type="ORF">C53D5.4</name>
        <name evidence="11" type="ORF">CELE_C53D5.4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293220.1">
        <property type="nucleotide sequence ID" value="NM_001306291.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKB8"/>
    <dbReference type="SMR" id="V6CKB8"/>
    <dbReference type="PeptideAtlas" id="V6CKB8"/>
    <dbReference type="GeneID" id="171617"/>
    <dbReference type="AGR" id="WB:WBGene00016905"/>
    <dbReference type="CTD" id="171617"/>
    <dbReference type="WormBase" id="C53D5.4f">
        <property type="protein sequence ID" value="CE49346"/>
        <property type="gene ID" value="WBGene00016905"/>
        <property type="gene designation" value="ztf-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_967190_0_0_1"/>
    <dbReference type="OrthoDB" id="5855904at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016905">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKB8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDK13481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C53D5.4f"/>
        </source>
    </evidence>
    <sequence length="151" mass="17133" checksum="E0CD5DA764FF19C3" modified="2014-02-19" version="1">MFGAGNIPHFQPPPDLYQHHHIPHTSQQVAQENLAMLANVPKLDDNNAYFDTFSPEKSGKRAKKRAAPSSAHEAQPNNGPYKCRDCEKTFRQKHGLNQHLLTHETNGAFECDGCGKRYSRQESVYRHQRSTPCTKYQNLTTVEHDDTGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKC7</accession>
    <name>V6CKC7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial potassium channel ATP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-binding cassette sub-family B member 8, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial sulfonylurea-receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 23" type="primary">haf-6</name>
        <name evidence="21" type="ORF">CELE_Y48G8AL.11</name>
        <name evidence="23" type="ORF">Y48G8AL.11</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293230.1">
        <property type="nucleotide sequence ID" value="NM_001306301.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKC7"/>
    <dbReference type="SMR" id="V6CKC7"/>
    <dbReference type="PeptideAtlas" id="V6CKC7"/>
    <dbReference type="GeneID" id="171694"/>
    <dbReference type="KEGG" id="cel:CELE_Y48G8AL.11"/>
    <dbReference type="AGR" id="WB:WBGene00001816"/>
    <dbReference type="CTD" id="171694"/>
    <dbReference type="WormBase" id="Y48G8AL.11b">
        <property type="protein sequence ID" value="CE49415"/>
        <property type="gene ID" value="WBGene00001816"/>
        <property type="gene designation" value="haf-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001816">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKC7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18574">
        <property type="entry name" value="ABC_6TM_ABCB8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000016">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000403">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF17">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="24" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="20">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="274"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDK13491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WormBase" id="Y48G8AL.11b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PeptideAtlas" id="V6CKC7"/>
        </source>
    </evidence>
    <sequence length="517" mass="56617" checksum="4081646EE0650064" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKD2</accession>
    <name>V6CKD2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y4C6B.7</name>
        <name evidence="3 5" type="ORF">Y4C6B.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293771.1">
        <property type="nucleotide sequence ID" value="NM_001306842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKD2"/>
    <dbReference type="PeptideAtlas" id="V6CKD2"/>
    <dbReference type="GeneID" id="3565268"/>
    <dbReference type="AGR" id="WB:WBGene00021161"/>
    <dbReference type="CTD" id="3565268"/>
    <dbReference type="WormBase" id="Y4C6B.7b">
        <property type="protein sequence ID" value="CE49171"/>
        <property type="gene ID" value="WBGene00021161"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1866945_0_0_1"/>
    <dbReference type="OrthoDB" id="5785959at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021161">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKD2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34721:SF10">
        <property type="entry name" value="ACTIVIN TYPES I AND II RECEPTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34721">
        <property type="entry name" value="PROTEIN CBG09734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004744498" evidence="2">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y4C6B.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="V6CKD2"/>
        </source>
    </evidence>
    <sequence length="137" mass="15100" checksum="A22A1B7DB8678B11" modified="2014-02-19" version="1">MTAKIGFLLILAVISTVSALRCFEGTVALDSNDQTSKKECGGMSNYCIQRIDKKTKEMRRECSSWSDEHSMEEKCPMTGCHFQTKDSTFCCCQFDECNEWKGDGTEFKAGETSSKSKAVPSAPKLGDVIMPTAATQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKD9</accession>
    <name>V6CKD9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Trehalase</fullName>
            <ecNumber evidence="2 4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tre-2</name>
        <name evidence="5" type="ORF">CELE_T05A12.2</name>
        <name evidence="7" type="ORF">T05A12.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2 4"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368400.1">
        <property type="nucleotide sequence ID" value="NM_001380293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKD9"/>
    <dbReference type="SMR" id="V6CKD9"/>
    <dbReference type="PeptideAtlas" id="V6CKD9"/>
    <dbReference type="GeneID" id="177451"/>
    <dbReference type="AGR" id="WB:WBGene00006608"/>
    <dbReference type="CTD" id="177451"/>
    <dbReference type="WormBase" id="T05A12.2c">
        <property type="protein sequence ID" value="CE49303"/>
        <property type="gene ID" value="WBGene00006608"/>
        <property type="gene designation" value="tre-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006451_4_1_1"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006608">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKD9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF24">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDK13501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="T05A12.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="V6CKD9"/>
        </source>
    </evidence>
    <sequence length="538" mass="61305" checksum="A6F1EB8D6183D054" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKE5</accession>
    <name>V6CKE5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_Y73B6BL.29</name>
        <name evidence="6 8" type="ORF">Y73B6BL.29</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKE5"/>
    <dbReference type="SMR" id="V6CKE5"/>
    <dbReference type="AGR" id="WB:WBGene00022250"/>
    <dbReference type="WormBase" id="Y73B6BL.29b">
        <property type="protein sequence ID" value="CE49331"/>
        <property type="gene ID" value="WBGene00022250"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074905_0_0_1"/>
    <dbReference type="OrthoDB" id="271910at2759"/>
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    <sequence length="183" mass="21439" checksum="3DAE74AB405B2E7F" modified="2014-02-19" version="1">MAVCRSWELWESIRQEPSISCFSERDYAWRLPPGFSAHKVLQAGKLFEGEQVMGSFFKHTAREKRYEPISPTALKYIFHVGLSKGEAYSMENDIYDYYNVTIVAKSFVREQIRRMMSCLVNYSYDRIPLTTIEWLLSNPISSNFFDLGIPVAPPQGLFLTDVVYDPRMFTNPEPYFLHSWDYD</sequence>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="WBGene00016291"/>
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        <property type="component" value="Chromosome IV"/>
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            <end position="406"/>
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        <location>
            <begin position="441"/>
            <end position="532"/>
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    </feature>
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            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
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            <begin position="463"/>
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        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="CDK13516.1"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="532" mass="60528" checksum="C1F6B2B57269A3E1" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKG1</accession>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditidae</taxon>
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    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    <dbReference type="AlphaFoldDB" id="V6CKG1"/>
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    <dbReference type="GeneID" id="171670"/>
    <dbReference type="AGR" id="WB:WBGene00022518"/>
    <dbReference type="CTD" id="171670"/>
    <dbReference type="WormBase" id="ZC123.3c">
        <property type="protein sequence ID" value="CE49338"/>
        <property type="gene ID" value="WBGene00022518"/>
        <property type="gene designation" value="zfh-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003443_1_0_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
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        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
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            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
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            <end position="356"/>
        </location>
    </feature>
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        <location>
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            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
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            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="730"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="956"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1029"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="651"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="958"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="566"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDK13521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="ZC123.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="V6CKG1"/>
        </source>
    </evidence>
    <sequence length="1235" mass="137742" checksum="2D12CCEA88E8E89C" modified="2014-02-19" version="1"> </sequence>
</entry>
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    <name>V6CKG6_CAEEL</name>
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        <name evidence="5" type="ORF">CELE_H35B03.2</name>
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    <organism evidence="5 6">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDK13526.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PeptideAtlas" id="V6CKG6"/>
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    <dbReference type="AGR" id="WB:WBGene00019264"/>
    <dbReference type="CTD" id="177349"/>
    <dbReference type="WormBase" id="H35B03.2d">
        <property type="protein sequence ID" value="CE49145"/>
        <property type="gene ID" value="WBGene00019264"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="17948at2759"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019264">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKG6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000137">
        <property type="entry name" value="Protein CBG19874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDK13526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="H35B03.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="V6CKG6"/>
        </source>
    </evidence>
    <sequence length="375" mass="42117" checksum="F886318C977F46CE" modified="2014-02-19" version="1">MEFTPMVPETTFQYADLSIKHIDAENTLAMVRRAIRMGYDAVAINIDLGDISDYYTELDMLWTPGSQNNVDGEPPKKKKKKQQRKDELADGIAGILKKKLIPPPHYVDVSQLNTSELEKRGKVFRQFSRITFTANEQVVINKVFIHPTILSYDIVAVRPGEPSVLDTLSRKTELFDIITIDHLEEERRKWLSVSKVMDRIRNDGVFYEIAYAESLMPATRKNTLFNGRVLIRSLKSKNIIFSSGAETMLDLRSPVDVMNMSLLWGVANNEARKMISGFPKNLLLQAECRGTGNGDVCSMKLSDAEKLAGNGEEEEQDGASEEKVVVGKEEEAEKVKAPPIEVRMNHSQYQALLQATKNANDMMKKIKASKAASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKH6</accession>
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        <submittedName>
            <fullName evidence="3">Zasp-like motif domain-containing protein</fullName>
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        <name evidence="3 5" type="primary">pqn-22</name>
        <name evidence="5" type="ORF">C46G7.4</name>
        <name evidence="3" type="ORF">CELE_C46G7.4</name>
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    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293796.1">
        <property type="nucleotide sequence ID" value="NM_001306867.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKH6"/>
    <dbReference type="PeptideAtlas" id="V6CKH6"/>
    <dbReference type="GeneID" id="177369"/>
    <dbReference type="KEGG" id="cel:CELE_C46G7.4"/>
    <dbReference type="AGR" id="WB:WBGene00004112"/>
    <dbReference type="CTD" id="177369"/>
    <dbReference type="WormBase" id="C46G7.4g">
        <property type="protein sequence ID" value="CE49140"/>
        <property type="gene ID" value="WBGene00004112"/>
        <property type="gene designation" value="pqn-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919374at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004112">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKH6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zasp-like motif" evidence="2">
        <location>
            <begin position="3"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="707"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="938"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C46G7.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="V6CKH6"/>
        </source>
    </evidence>
    <sequence length="1080" mass="121644" checksum="24F6A36432D94785" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>V6CLL6</accession>
    <name>V6CLL6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UAA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">hut-1</name>
        <name evidence="1" type="ORF">CELE_Y111B2A.20</name>
        <name evidence="3" type="ORF">Y111B2A.20</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDK13499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293604.1">
        <property type="nucleotide sequence ID" value="NM_001306675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CLL6"/>
    <dbReference type="SMR" id="V6CLL6"/>
    <dbReference type="PeptideAtlas" id="V6CLL6"/>
    <dbReference type="GeneID" id="176690"/>
    <dbReference type="KEGG" id="cel:CELE_Y111B2A.20"/>
    <dbReference type="AGR" id="WB:WBGene00013740"/>
    <dbReference type="CTD" id="176690"/>
    <dbReference type="WormBase" id="Y111B2A.20b">
        <property type="protein sequence ID" value="CE49162"/>
        <property type="gene ID" value="WBGene00013740"/>
        <property type="gene designation" value="hut-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036019_1_0_1"/>
    <dbReference type="OrthoDB" id="78344at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013740">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CLL6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y111B2A.20b"/>
        </source>
    </evidence>
    <sequence length="46" mass="4859" checksum="D4041F9BF08C8F6D" modified="2014-02-19" version="1">MNHPLSGRQILATTVVFSALTADVVDGKMTAAKKPLAATEPKVHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>W6RQR8</accession>
    <name>W6RQR8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD and tetratricopeptide repeats protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">adpr-1</name>
        <name evidence="3" type="ORF">CELE_Y73E7A.9</name>
        <name evidence="5" type="ORF">Y73E7A.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293408.1">
        <property type="nucleotide sequence ID" value="NM_001306479.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RQR8"/>
    <dbReference type="SMR" id="W6RQR8"/>
    <dbReference type="PeptideAtlas" id="W6RQR8"/>
    <dbReference type="GeneID" id="3565128"/>
    <dbReference type="AGR" id="WB:WBGene00044440"/>
    <dbReference type="CTD" id="3565128"/>
    <dbReference type="WormBase" id="Y73E7A.9b">
        <property type="protein sequence ID" value="CE49589"/>
        <property type="gene ID" value="WBGene00044440"/>
        <property type="gene designation" value="adpr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012381_3_1_1"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044440">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RQR8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM63464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y73E7A.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="W6RQR8"/>
        </source>
    </evidence>
    <sequence length="350" mass="39954" checksum="39DBF0B3732F159C" modified="2014-04-16" version="1">MLTFSPLGANTYAYHATHVAFNKRGTEVVVNHGGGGGVYVFSVDAELDPKYMDRFHSVMELPREPVITSGALPYPDLREIGSTAIREKHFAKAIDFYSDLIYRNDDRESHQDHRAFLSVCHSNRATALLLRRQRGDTYACVRDCIKALEIHRGNSKALLRLIKSFTTMEHIGLARKCVQKFKEWYPNDTAIEKMEEDVEALTPNDRPELVAPEGVVDYQERYGGSTNHQTDIKEANFFGSRDQYIIAGSDCGHMYIWNRDTSKIQGIFEADDHILNICQPHPDQFMIATAGIDDDILLWQPILERPDAFLSRRVEDPYEFMEKRADGMGGRIHLHMLRDLARDNSQCVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6RQS3</accession>
    <name>W6RQS3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C06A6.2</name>
        <name evidence="2" type="ORF">CELE_C06A6.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368435.1">
        <property type="nucleotide sequence ID" value="NM_001380343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RQS3"/>
    <dbReference type="SMR" id="W6RQS3"/>
    <dbReference type="PeptideAtlas" id="W6RQS3"/>
    <dbReference type="GeneID" id="177573"/>
    <dbReference type="AGR" id="WB:WBGene00015507"/>
    <dbReference type="CTD" id="177573"/>
    <dbReference type="WormBase" id="C06A6.2c">
        <property type="protein sequence ID" value="CE49576"/>
        <property type="gene ID" value="WBGene00015507"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_980822_0_0_1"/>
    <dbReference type="OrthoDB" id="5854136at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015507">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RQS3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM63469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C06A6.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="W6RQS3"/>
        </source>
    </evidence>
    <sequence length="324" mass="35247" checksum="7DF41DA4DEC377C2" modified="2014-04-16" version="1">MPAFLPENFIKTEEPSSSAGLSARLAIASPSGSSQSEDSRMAASSPSTAFIGMPTTINGNKSIQTVLDNLIAARSKKEDHAASTTSVLQAPNYSELKQMLEKNNILKVDNENGPPLKRVKQEIESPPGSSRMIVYNDTRKTTNAPISTWVPPREDLTAKVKDETVQSVPQRKAQATAVIKSGFPLEKHLKKMIQQAVPSMIPVTSSSIPQRNGILGLNSMILPPSAIQQALLKKMDVPTTTPSMSSTSSSQAQSSMNGVINGNNTEVEDKWTLLGRMIAMMAREIETRDPMSACELTRDLQQVIFQYNMKTLRPKENNSSSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>W6RQW7</accession>
    <name>W6RQW7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">dapk-1</name>
        <name evidence="9" type="ORF">CELE_K12C11.4</name>
        <name evidence="11" type="ORF">K12C11.4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293417.1">
        <property type="nucleotide sequence ID" value="NM_001306488.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RQW7"/>
    <dbReference type="SMR" id="W6RQW7"/>
    <dbReference type="PeptideAtlas" id="W6RQW7"/>
    <dbReference type="GeneID" id="187322"/>
    <dbReference type="AGR" id="WB:WBGene00003400"/>
    <dbReference type="CTD" id="187322"/>
    <dbReference type="WormBase" id="K12C11.4d">
        <property type="protein sequence ID" value="CE49601"/>
        <property type="gene ID" value="WBGene00003400"/>
        <property type="gene designation" value="dapk-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003400">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RQW7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08782">
        <property type="entry name" value="Death_DAPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Roc" evidence="8">
        <location>
            <begin position="341"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="7">
        <location>
            <begin position="821"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
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            <dbReference type="PeptideAtlas" id="W6RR23"/>
        </source>
    </evidence>
    <sequence length="182" mass="20603" checksum="5B67F27C58EF83B4" modified="2014-04-16" version="1">MGFAKVGRKKLFLYDSQMQTYEGEILCLLDFYVHFSCQRQGVGQQILDYMFSQEHTEPYQLALDNPSVTLLGFMSQKYGLIKPVWQNTNFVVFEELFLALSAENGIEKPPPDGWRRPMTPRRLGTGMTDTRWLQHAVSGHQSKGNAMAAPVDADMTPQGALSNRAHQAKARKAHILSSKPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W6RR25</accession>
    <name>W6RR25_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CELE_Y48G8AL.13</name>
        <name evidence="9 11" type="ORF">Y48G8AL.13</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63560.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293436.2">
        <property type="nucleotide sequence ID" value="NM_001306507.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RR25"/>
    <dbReference type="GeneID" id="171699"/>
    <dbReference type="KEGG" id="cel:CELE_Y48G8AL.13"/>
    <dbReference type="AGR" id="WB:WBGene00021691"/>
    <dbReference type="CTD" id="171699"/>
    <dbReference type="WormBase" id="Y48G8AL.13b">
        <property type="protein sequence ID" value="CE50279"/>
        <property type="gene ID" value="WBGene00021691"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1039111_0_0_1"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021691">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RR25">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF19">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM63560.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y48G8AL.13b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="W6RR25"/>
        </source>
    </evidence>
    <sequence length="192" mass="22002" checksum="967E38296DCF2749" modified="2015-11-11" version="2">MGYFIYDLLDMHIHGELESSKEYLIHHSLVITAFSIILLSGRLFGLAMIALLVEIQTVFLHLRTMVRLLYGSKHMPASIDVLINANMICLFLFRHLPVCYLLFYLIAQDVKVPILLKLFLVGGLTFLEYHNTHLTMAMAKSDGFFGHERQALDEDSCDPLGSLKKDQEVEQKQQQKSERSERSTKTTAKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H9W7</accession>
    <name>A0A168H9W7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ELM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">lin-40</name>
        <name evidence="15" type="ORF">CELE_T27C4.4</name>
        <name evidence="17" type="ORF">T27C4.4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the metastasis-associated protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317834.1">
        <property type="nucleotide sequence ID" value="NM_001330804.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H9W7"/>
    <dbReference type="SMR" id="A0A168H9W7"/>
    <dbReference type="GeneID" id="178788"/>
    <dbReference type="KEGG" id="cel:CELE_T27C4.4"/>
    <dbReference type="AGR" id="WB:WBGene00003025"/>
    <dbReference type="CTD" id="178788"/>
    <dbReference type="WormBase" id="T27C4.4e">
        <property type="protein sequence ID" value="CE51633"/>
        <property type="gene ID" value="WBGene00003025"/>
        <property type="gene designation" value="lin-40"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2193595at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003025">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A168H9W7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.50:FF:000001">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000042">
        <property type="entry name" value="Protein CBR-LIN-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF29">
        <property type="entry name" value="METASTASIS ASSOCIATED 1-LIKE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="13">
        <location>
            <begin position="144"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="344"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="181"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SAP35596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="T27C4.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="A0A168H9W7"/>
        </source>
    </evidence>
    <sequence length="735" mass="81509" checksum="895D7B87E836B538" modified="2016-07-06" version="1"> </sequence>
</entry>
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            <taxon>Rhabditina</taxon>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="18"/>
        </location>
    </feature>
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            <begin position="19"/>
            <end position="174"/>
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    </evidence>
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            <dbReference type="EMBL" id="VAY52143.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="T25D10.3c"/>
        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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        <property type="gene designation" value="chts-1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A4V0INQ1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <end position="351"/>
        </location>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VTW47579.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A4V0INQ1"/>
        </source>
    </evidence>
    <sequence length="1283" mass="140602" checksum="3735E3CF722E355B" modified="2019-07-31" version="1"> </sequence>
</entry>
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    <accession>A0A4V0INR9</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">CELE_F49E2.5</name>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="WBGene00009888"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN CBG12783"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04747">
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    </dbReference>
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    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="848"/>
        </location>
    </feature>
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        <location>
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            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="165"/>
        </location>
    </feature>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
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            <begin position="750"/>
            <end position="760"/>
        </location>
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    </feature>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <source>
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    </dbReference>
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    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG8860232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T27A3.8b"/>
        </source>
    </evidence>
    <sequence length="84" mass="9791" checksum="1D6CCB735EDCF625" modified="2022-01-19" version="1">MIFLPVKLAFLTFSSIPSFIAIHAAPVISFICEFLLLSLHITRMMLSVSFLWMWELAINTELLDFLEIVFTFNSEEYEQQVDLN</sequence>
</entry>
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    <accession>A0A8D9I9M5</accession>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-Gid-type" evidence="7">
        <location>
            <begin position="331"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="6">
        <location>
            <begin position="331"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG8860262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="T07D1.2b"/>
        </source>
    </evidence>
    <sequence length="416" mass="48063" checksum="F27595C41655EA75" modified="2022-01-19" version="1">MRRMFNCRQEEKVNAIRACAGEIRFNACEYLINWSKNLEMVENSLINMRTKLFLNYNLEEVSITGQILMETAAERAAKVAKEAASHHKLMHLHISKMGRLIDKQVDRHFITPFRGTFDLNDSKLSRQLTIAMIYDFSMCNGLTDTGVALKKMSDVDEKYSITEPDTLQQIVSDLREGDIESSLDYLEAAQPEEDGNIRTYLHTQLITDNIELGSNNYDKAVKDLRRFKSPFVDDRQKFKHLVGALLVGKPSMIDIRYKYLFDFTNREILTLKMASFFIPYEAPLKNLMRFGMHAMIQLGDLFPVGFAPAAIDDNELPIEIGFHATHSSFTCPILKEQCDAENPPMRLICGHVISKDAINRLTTSIRQQRNSSRLSKFKCPYCPREQLLENTRQVDFLKWCESDYTDEEVQLFQFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-04" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>B5U8M8</accession>
    <name>B5U8M8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="ORF">C56A3.4</name>
        <name evidence="5" type="ORF">CELE_C56A3.4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAR64660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129886.1">
        <property type="nucleotide sequence ID" value="NM_001136414.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5U8M8"/>
    <dbReference type="SMR" id="B5U8M8"/>
    <dbReference type="GeneID" id="179836"/>
    <dbReference type="KEGG" id="cel:CELE_C56A3.4"/>
    <dbReference type="AGR" id="WB:WBGene00008343"/>
    <dbReference type="CTD" id="179836"/>
    <dbReference type="WormBase" id="C56A3.4b">
        <property type="protein sequence ID" value="CE43031"/>
        <property type="gene ID" value="WBGene00008343"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2322505_0_0_1"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5U8M8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAR64660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C56A3.4b"/>
        </source>
    </evidence>
    <sequence length="99" mass="11367" checksum="0C5025593B1560D5" modified="2008-11-04" version="1">MFATEFINFNISRAAPIRRTVEAIHGPKPPKAGVKSVEDSINEARLQCFLCKLTEKRVLLRPCNHLCFCEPCNDTFQKQIPLLCPICHMHVQSFEIVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-04" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>B5U8N0</accession>
    <name>B5U8N0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty-acid and retinol-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">far-5</name>
        <name evidence="7" type="ORF">CELE_F15B9.3</name>
        <name evidence="9" type="ORF">F15B9.3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty-acid and retinol-binding protein (FARBP) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAR64664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129891.1">
        <property type="nucleotide sequence ID" value="NM_001136419.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5U8N0"/>
    <dbReference type="SMR" id="B5U8N0"/>
    <dbReference type="PeptideAtlas" id="B5U8N0"/>
    <dbReference type="GeneID" id="184522"/>
    <dbReference type="KEGG" id="cel:CELE_F15B9.3"/>
    <dbReference type="AGR" id="WB:WBGene00001389"/>
    <dbReference type="CTD" id="184522"/>
    <dbReference type="WormBase" id="F15B9.3b">
        <property type="protein sequence ID" value="CE43005"/>
        <property type="gene ID" value="WBGene00001389"/>
        <property type="gene designation" value="far-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117803_0_0_1"/>
    <dbReference type="OrthoDB" id="5808308at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001389">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5U8N0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008632">
        <property type="entry name" value="Gp-FAR-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05823">
        <property type="entry name" value="Gp-FAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAR64664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F15B9.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="B5U8N0"/>
        </source>
    </evidence>
    <sequence length="69" mass="7711" checksum="5D1DA2DB0EFA4357" modified="2008-11-04" version="1">MLGIGRAIYTAQIVGIPLDSKEVLPVFAKQFTSFKSLSDATKEELEKTFLGLYKFASNDKIKTEIDKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-04" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>B5U8N2</accession>
    <name>B5U8N2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">ret-1</name>
        <name evidence="9" type="ORF">CELE_W06A7.3</name>
        <name evidence="11" type="ORF">W06A7.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAR64686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129910.1">
        <property type="nucleotide sequence ID" value="NM_001136438.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5U8N2"/>
    <dbReference type="SMR" id="B5U8N2"/>
    <dbReference type="PeptideAtlas" id="B5U8N2"/>
    <dbReference type="GeneID" id="179981"/>
    <dbReference type="AGR" id="WB:WBGene00004336"/>
    <dbReference type="CTD" id="179981"/>
    <dbReference type="WormBase" id="W06A7.3g">
        <property type="protein sequence ID" value="CE43037"/>
        <property type="gene ID" value="WBGene00004336"/>
        <property type="gene designation" value="ret-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478366_0_0_1"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004336">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5U8N2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2480:FF:000002">
        <property type="entry name" value="Reticulon-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046964">
        <property type="entry name" value="RTN1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799:SF2">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="299"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAR64686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="W06A7.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="B5U8N2"/>
        </source>
    </evidence>
    <sequence length="494" mass="54516" checksum="B8D128C6CF1CCFAF" modified="2008-11-04" version="1">MSSHHNDVIEKNYFNDNAPTAALLESPIAEEARKLVQDAVESASEYKKQAVDSGDEIGRELLDNVEQKIEQVKEPIVDSLHKAYDGVGDFVHETVPNAVDDFVREAEKQLPESPVPEKIETPEPLVDIHDTVDKVHDEVDNFLRREPTPPFETDDVAPLSDDKPQFGNQTPEEDETTFDRKGPLTIPEEVEKAAAAQNNDLDDFDPLVTSNTGAAFGAAVGAAAAVESLTEEEMFGHQKFETVPRPPTPPKDISDEDVKPSTVNLGPSHHHSHPSSPHHSILKHHGDAWIDFKTVPPCVLDVIYWRDAKKSAIVLSLALLVLFVLAKYPLLTVVTYSLLLALGAAAGFRVFKKVEAQIKKTDSEHPFSEILAQDLTLPQEKVHAQADVFVEHATCIANKLKKLVFVESPLESIKFGLVLWSLTYIASWFSGFTLAILGLLGVFSVPKVYESNQEAIDPHLATISGHLKNVQNIIDEKLPFLRSAPVAAEEKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-04" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B5U8N3</accession>
    <name>B5U8N3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Essential MCU regulator, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C15H11.11</name>
        <name evidence="2" type="ORF">CELE_C15H11.11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAR64655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129879.1">
        <property type="nucleotide sequence ID" value="NM_001136407.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5U8N3"/>
    <dbReference type="GeneID" id="3564906"/>
    <dbReference type="KEGG" id="cel:CELE_C15H11.11"/>
    <dbReference type="AGR" id="WB:WBGene00007619"/>
    <dbReference type="CTD" id="3564906"/>
    <dbReference type="WormBase" id="C15H11.11b">
        <property type="protein sequence ID" value="CE42976"/>
        <property type="gene ID" value="WBGene00007619"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183961_0_0_1"/>
    <dbReference type="OrthoDB" id="5803790at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007619">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5U8N3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR64655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C15H11.11b"/>
        </source>
    </evidence>
    <sequence length="71" mass="7824" checksum="001A9999CA114451" modified="2008-11-04" version="1">MLPDIGTSAEFTFSRVPVFPGLRKPGKRIIAIYLASASIGFAAAWFGAATFDQVNLKIDSYKDRLDIVPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-04" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>B5U8N5</accession>
    <name>B5U8N5_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">DUF38 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">fbxa-82</name>
        <name evidence="4" type="ORF">C25D7.4</name>
        <name evidence="2" type="ORF">CELE_C25D7.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAR64657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129881.1">
        <property type="nucleotide sequence ID" value="NM_001136409.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5U8N5"/>
    <dbReference type="GeneID" id="182883"/>
    <dbReference type="KEGG" id="cel:CELE_C25D7.4"/>
    <dbReference type="AGR" id="WB:WBGene00007716"/>
    <dbReference type="CTD" id="182883"/>
    <dbReference type="WormBase" id="C25D7.4b">
        <property type="protein sequence ID" value="CE43016"/>
        <property type="gene ID" value="WBGene00007716"/>
        <property type="gene designation" value="fbxa-82"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030831_3_1_1"/>
    <dbReference type="OrthoDB" id="10672783at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007716">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5U8N5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002900">
        <property type="entry name" value="DUF38/FTH_CAE_spp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23014:SF1">
        <property type="entry name" value="DUF38 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23014">
        <property type="entry name" value="F-BOX A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01827">
        <property type="entry name" value="FTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF38" evidence="1">
        <location>
            <begin position="93"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR64657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C25D7.4b"/>
        </source>
    </evidence>
    <sequence length="269" mass="31821" checksum="58667367A4E9AC6A" modified="2008-11-04" version="1">MVMEPGFKEIKVDFIERNVHLILDGNVLQYKPTKTGCIVKRNNHFSSLKNHDYIETAIRDLRLIFKRPKLELHLFSVIIEILYKKEERDRLYMFLTELMRRVEPINTKTISFTRMHCEEMKSILSLLNANNIEKIELNFHHGILLENYLAQLEQWKNAKELCASAVFAGFYTSIENLFNFRKFEINLETFTVADAVKIKNILLNSANFNYCKIEYSMQFVAHRFEVARLFQPSNTNGNLDYFAYKCSGGNYIIFLDDYHLEIQRENDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-04" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B5U8N8</accession>
    <name>B5U8N8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C25F9.10</name>
        <name evidence="2" type="ORF">CELE_C25F9.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAR64658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129883.1">
        <property type="nucleotide sequence ID" value="NM_001136411.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5U8N8"/>
    <dbReference type="GeneID" id="3565079"/>
    <dbReference type="AGR" id="WB:WBGene00044291"/>
    <dbReference type="CTD" id="3565079"/>
    <dbReference type="WormBase" id="C25F9.10b">
        <property type="protein sequence ID" value="CE42988"/>
        <property type="gene ID" value="WBGene00044291"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135809_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044291">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5U8N8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21516:SF4">
        <property type="entry name" value="AAA_LID_7 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21516">
        <property type="entry name" value="AAA_LID_7 DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR64658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C25F9.10b"/>
        </source>
    </evidence>
    <sequence length="140" mass="15889" checksum="94F7F76BC5657EB8" modified="2008-11-04" version="1">MSEQDPPDIVIFSNLIWGAAVVCLRKFFLDRLKLEISGQNAQEILMEIVVDSFTDDTGGHLHRAWTFANHCRKSAYTLGYINQLLRNEILQSVANMEAYMNAADSEKIKEKISTSGLQITYSKNIVKIGNYQFSFNKVAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-08-12" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRL6-2</accession>
    <name>ZHP3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform a of Zip homologous protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Zip3-homologous protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zhp-3</name>
        <name evidence="5" type="ORF">K02B12.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2004" name="Mol. Cell. Biol." volume="24" first="7998" last="8006">
            <title>Targeted gene knockout reveals a role in meiotic recombination for ZHP-3, a Zip3-related protein in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Jantsch V."/>
                <person name="Pasierbek P."/>
                <person name="Mueller M.M."/>
                <person name="Schweizer D."/>
                <person name="Jantsch M."/>
                <person name="Loidl J."/>
            </authorList>
            <dbReference type="PubMed" id="15340062"/>
            <dbReference type="DOI" id="10.1128/mcb.24.18.7998-8006.2004"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="e1000235" last="e1000235">
            <title>ZHP-3 acts at crossovers to couple meiotic recombination with synaptonemal complex disassembly and bivalent formation in C. elegans.</title>
            <authorList>
                <person name="Bhalla N."/>
                <person name="Wynne D.J."/>
                <person name="Jantsch V."/>
                <person name="Dernburg A.F."/>
            </authorList>
            <dbReference type="PubMed" id="18949042"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000235"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2013" name="Cell Death Differ." volume="20" first="1209" last="1218">
            <title>Pro-crossover factors regulate damage-dependent apoptosis in the Caenorhabditis elegans germ line.</title>
            <authorList>
                <person name="Silva N."/>
                <person name="Adamo A."/>
                <person name="Santonicola P."/>
                <person name="Martinez-Perez E."/>
                <person name="La Volpe A."/>
            </authorList>
            <dbReference type="PubMed" id="23832114"/>
            <dbReference type="DOI" id="10.1038/cdd.2013.68"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>A compartmentalized signaling network mediates crossover control in meiosis.</title>
            <authorList>
                <person name="Zhang L."/>
                <person name="Koehler S."/>
                <person name="Rillo-Bohn R."/>
                <person name="Dernburg A.F."/>
            </authorList>
            <dbReference type="PubMed" id="29521627"/>
            <dbReference type="DOI" id="10.7554/elife.30789"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ZHP-4</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2018" name="PLoS Genet." volume="14" first="e1007653" last="e1007653">
            <title>BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis.</title>
            <authorList>
                <person name="Janisiw E."/>
                <person name="Dello Stritto M.R."/>
                <person name="Jantsch V."/>
                <person name="Silva N."/>
            </authorList>
            <dbReference type="PubMed" id="30383754"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1007653"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="2" key="7">
        <citation type="journal article" date="2018" name="PLoS Genet." volume="14" first="E1007776" last="E1007776">
            <title>C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata.</title>
            <authorList>
                <person name="Nguyen H."/>
                <person name="Labella S."/>
                <person name="Silva N."/>
                <person name="Jantsch V."/>
                <person name="Zetka M."/>
            </authorList>
            <dbReference type="PubMed" id="30379819"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1007776"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF HIS-25</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>C6KRL6-1</id>
            <name evidence="5">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>C6KRL6-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_060674"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001250801.1">
        <property type="nucleotide sequence ID" value="NM_001263872.3"/>
    </dbReference>
    <dbReference type="WormBase" id="K02B12.8a">
        <property type="protein sequence ID" value="CE34201"/>
        <property type="gene ID" value="WBGene00006976"/>
        <property type="gene designation" value="zhp-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="15340062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="K02B12.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="K02B12.8b"/>
        </source>
    </evidence>
    <sequence length="387" mass="43382" checksum="B9F78C6425DA22CB" modified="2009-09-01" version="1">MDFVHCNKCFNRKPPDGFFISSCFHIFCTKCAKADLAVCLICKKNVRLVRLDGNISSGIKIYFADPIKMVADSLAKIQKKIDFQQSTRDHLVKYLTKEKEKKRQMEVYFRTKGQEFDSQRKKLAEATAWIQMAEKKLQASEEERVKAEREIEECQAKLKSMTNLMSADTLGMNSQTPFPFSLAESQETAPSLVESSANSTFNMVSPLVSSPASSPNSINYNSFFENGSRTRPESLNEEAMFNTMSSGQSANANTSESSAFSVAFNNIFTPSRNNMGDSSMINKTTANQTIMDKTSMSLENWRQNRANSFGVHDISKRDSSLPTGGGSAIRVHHFKQNSRITPIAQNRRSAAGFDRQQIQEMRRISSQPGYLAQRKPINGRSFIGPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C9IY22</accession>
    <name>C9IY22_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_ZK1058.9</name>
        <name evidence="1 3" type="ORF">ZK1058.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CBG22756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254884.1">
        <property type="nucleotide sequence ID" value="NM_001267955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C9IY22"/>
    <dbReference type="PeptideAtlas" id="C9IY22"/>
    <dbReference type="GeneID" id="175508"/>
    <dbReference type="AGR" id="WB:WBGene00014207"/>
    <dbReference type="CTD" id="175508"/>
    <dbReference type="WormBase" id="ZK1058.9b">
        <property type="protein sequence ID" value="CE44175"/>
        <property type="gene ID" value="WBGene00014207"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077489_0_0_1"/>
    <dbReference type="OrthoDB" id="5836460at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014207">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C9IY22">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBG22756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="ZK1058.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="C9IY22"/>
        </source>
    </evidence>
    <sequence length="224" mass="26668" checksum="D10D739728BD2342" modified="2009-11-03" version="1">MPEYNNYRFNRSRSVDLSSISREKYLSRWSRENTPVDNEKRYASHVRRSYTPVREISAVNNVNDGNLHRSRTPLATVTAPYHTNIHYRSENEPFRKYDVYGLRTWSYPIYKYVYGREGDYRRPYSFDRNYGLTPSYTPPQLTAESRPITTRRGYSGYSYLANETHYDITSRPKSLSSYMYSNKYLGTTAAPWYWSCYGNSGLRHFNSYRPHNYTSSTASWSRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>C9IY29</accession>
    <accession>T2DLM4</accession>
    <name>C9IY29_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">inx-11</name>
        <name evidence="12" type="synonym">inx</name>
        <name evidence="15" type="ORF">CELE_W04D2.3</name>
        <name evidence="14 17" type="ORF">W04D2.3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <title>Six innexins contribute to electrical coupling of Caenorhabditis elegans body-wall muscle.</title>
            <authorList>
                <person name="Wang Z.-W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">N2 Bristol</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KF137645">
        <property type="protein sequence ID" value="AGV53077.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBG22748.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359736.1">
        <property type="nucleotide sequence ID" value="NM_001373129.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C9IY29"/>
    <dbReference type="SMR" id="C9IY29"/>
    <dbReference type="PeptideAtlas" id="C9IY29"/>
    <dbReference type="GeneID" id="179710"/>
    <dbReference type="AGR" id="WB:WBGene00002133"/>
    <dbReference type="CTD" id="179710"/>
    <dbReference type="WormBase" id="W04D2.3b">
        <property type="protein sequence ID" value="CE53090"/>
        <property type="gene ID" value="WBGene00002133"/>
        <property type="gene designation" value="inx-11"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035763_0_2_1"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002133">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C9IY29">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF31">
        <property type="entry name" value="INNEXIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGV53077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBG22748.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="W04D2.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="C9IY29"/>
        </source>
    </evidence>
    <sequence length="465" mass="53960" checksum="905E3732DEA8849A" modified="2019-06-05" version="2">MSIEGLLGSVSRCIWRYDQDYSDRLHTTVTSNILVALAGVASWKTWAGGSPIECAIPAMFSESVSAYAENYCWSQDTYFVEPTQDVSLLKKEERYTPDRQLSYYQWVPFFLLLQAAFFRAPSYLWKYFSNHSGIRIHEVVEKAKDSANVEEEVREKNILILKRHLSSALRFQANMERKKVQVHKTVTFLNFQYSSGFISWIYLFTKVLYFLNVFAQLYLMNYFLGTNRHHWYGFGVVQDIVQGEPWERSGYFPRAAVCDFEVRQVANIQRYSVQCVLVINIFNEKIFVLLWFWYVILLLSSTVSLVQWFIVLVFPCFSKWFVKQHLALSTLQNFNQRNSRREDSDVSKFVTQYLHKDGVFVLRMVSSHAGIIFATDLVQALYEAYDFQDKNKDVQGSPVSDDLQTISTGAESSIRQRKTRKGSRIEYKAGFPISTSLMPDKDDIESSSTSSEEDQKRVSNVITNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C9IY37</accession>
    <name>C9IY37_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F48F5.6</name>
        <name evidence="2 4" type="ORF">F48F5.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBG22739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256918.1">
        <property type="nucleotide sequence ID" value="NM_001269989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C9IY37"/>
    <dbReference type="PeptideAtlas" id="C9IY37"/>
    <dbReference type="GeneID" id="259685"/>
    <dbReference type="KEGG" id="cel:CELE_F48F5.6"/>
    <dbReference type="AGR" id="WB:WBGene00009848"/>
    <dbReference type="CTD" id="259685"/>
    <dbReference type="WormBase" id="F48F5.6b">
        <property type="protein sequence ID" value="CE44160"/>
        <property type="gene ID" value="WBGene00009848"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2887877_0_0_1"/>
    <dbReference type="OrthoDB" id="5855105at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009848">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C9IY37">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002997060" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBG22739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F48F5.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="C9IY37"/>
        </source>
    </evidence>
    <sequence length="63" mass="7264" checksum="ADA03505A11293D6" modified="2009-11-03" version="1">MFALFVLIIFTSYRRHTHTRRETAKRTPLSIDCPDLDYIDARNTNLVSSTVQVESVHQTPTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C9IY39</accession>
    <name>C9IY39_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T16G1.2</name>
        <name evidence="2 4" type="ORF">T16G1.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBG22747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256469.1">
        <property type="nucleotide sequence ID" value="NM_001269540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C9IY39"/>
    <dbReference type="SMR" id="C9IY39"/>
    <dbReference type="GeneID" id="188552"/>
    <dbReference type="AGR" id="WB:WBGene00011796"/>
    <dbReference type="CTD" id="188552"/>
    <dbReference type="WormBase" id="T16G1.2b">
        <property type="protein sequence ID" value="CE44167"/>
        <property type="gene ID" value="WBGene00011796"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1338632_0_0_1"/>
    <dbReference type="OrthoDB" id="5876340at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011796">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C9IY39">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002997232" evidence="1">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBG22747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T16G1.2b"/>
        </source>
    </evidence>
    <sequence length="205" mass="23218" checksum="183CAE057A6EE253" modified="2009-11-03" version="1">MNLLQVLLSSFLLAVESQVAPIVHPALLEGPQNEVVPSLIFPSNRVGSKNRLRSRVFRDASSQGYKGLVDSPRLFRASGRFHKRVQSATTHDIQNVPLPQETLQIVSYKYDAEKHDEKKMSDNDVITNEEAEDHARGIERTTMSIKPREGEITEPMTTTTQMPEHNSINVSFQCTSKKKTTAKKGVKKSEKIVFNQFVQKHFSKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>G2HK15-2</accession>
    <name>APTF2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Transcription factor aptf-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aptf-2</name>
        <name evidence="5" type="ORF">Y62E10A.17</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="e1006048" last="e1006048">
            <title>The AP-2 Transcription Factor APTF-2 Is Required for Neuroblast and Epidermal Morphogenesis in Caenorhabditis elegans Embryogenesis.</title>
            <authorList>
                <person name="Budirahardja Y."/>
                <person name="Tan P.Y."/>
                <person name="Doan T."/>
                <person name="Weisdepp P."/>
                <person name="Zaidel-Bar R."/>
            </authorList>
            <dbReference type="PubMed" id="27176626"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006048"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF GLU-182</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G2HK15-1</id>
            <name evidence="5">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G2HK15-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_061131"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255741.1">
        <property type="nucleotide sequence ID" value="NM_001268812.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y62E10A.17a">
        <property type="protein sequence ID" value="CE25526"/>
        <property type="gene ID" value="WBGene00013383"/>
        <property type="gene designation" value="aptf-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="27176626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y62E10A.17a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y62E10A.17b"/>
        </source>
    </evidence>
    <sequence length="363" mass="39444" checksum="2390E5EDE1913C53" modified="2011-11-16" version="1">MFTTLNSTVPTEPVVGPVEPTVPTVPATKETGPSSSAECSTQPAVAEQEDNSLLAQLLKGKITSDDAKLQPPRGPFEYAPMLSEEAQFAIKLAGLLNPNPVTEQDPSTFKPPPKMSNNVRKNINLTPVIENAVPSGFELESPKDQAFDVVHGRLSMGQNQTCYFVTVEEMRRRLQSPEKLNSSSIACNLKRPKLKNGGELMRAQLRDHGIKVQLNAKQKAFPNKVIALVEAEAVHLGLDLGTAVRDDYPVQDIIQEVAHEALADEDADLDALMNDKDFTECMSALESVFTSVVPPITGIEPKPSNNMRLNNGMETFSSASHGLGIVSQRVWLPQLTAIGNGVASELRRLTETPTESKPEELKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G4RZ45</accession>
    <name>G4RZ45_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enhanced RNAI (RNA interference)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">eri-6</name>
        <name evidence="3" type="ORF">C41D11.1</name>
        <name evidence="1" type="ORF">CELE_C41D11.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD64251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001249624.1">
        <property type="nucleotide sequence ID" value="NM_001262695.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4RZ45"/>
    <dbReference type="GeneID" id="172050"/>
    <dbReference type="AGR" id="WB:WBGene00016561"/>
    <dbReference type="CTD" id="172050"/>
    <dbReference type="WormBase" id="C41D11.1a">
        <property type="protein sequence ID" value="CE08658"/>
        <property type="gene ID" value="WBGene00016561"/>
        <property type="gene designation" value="eri-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016561">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G4RZ45">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD64251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C41D11.1a"/>
        </source>
    </evidence>
    <sequence length="320" mass="37936" checksum="763855D77B005627" modified="2012-01-25" version="2">MTDKENFYSGFFLGRLPGSFDSRFLIKVACFQPGKEERNVFELTTDTKREEDYGEMVHFWVDKGPLQNKSFVRFEENYETFFIHENKMFDRIVHTDKDFYVGVNDLPDSDIYIHPDLGKMIDTRSIVTPGKKYNFITFEVKQNENNSFDIEIVGGEVQGKEKNSEEPSAKEKIIQKMEQVHEVMKVEYEYNKNEETANWDVIGHLKLIKFYDKDLTSGLRPVLRLMDNRHVALFKKQRETMPIKMIKVIEVDGIWKDDVNFVPQEGTLLPTDHDEKTVVLLGNDYRHKFERLFKREDVFRLESNNTLTHLKFWQYGLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G4RZ46</accession>
    <name>G4RZ46_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enhanced RNAI (RNA interference)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">eri-6</name>
        <name evidence="3" type="ORF">C41D11.1</name>
        <name evidence="1" type="ORF">CELE_C41D11.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD64261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367500.1">
        <property type="nucleotide sequence ID" value="NM_001379821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4RZ46"/>
    <dbReference type="GeneID" id="172050"/>
    <dbReference type="AGR" id="WB:WBGene00016561"/>
    <dbReference type="CTD" id="172050"/>
    <dbReference type="WormBase" id="C41D11.1b">
        <property type="protein sequence ID" value="CE43749"/>
        <property type="gene ID" value="WBGene00016561"/>
        <property type="gene designation" value="eri-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016561">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G4RZ46">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD64261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C41D11.1b"/>
        </source>
    </evidence>
    <sequence length="337" mass="39868" checksum="B389DC13A460ED47" modified="2012-01-25" version="2">MTDKENFYSGFFLGRLPGSFDSRFLIKVACFQPGKEERNVFELTTDTKREEDYGEMVHFWVDKGPLQNKSFVRFEENYETFFIHENKMFDRIVHTDKDFYVGVNDLPDSDIYIHPDLGKMIDTRSIVTPGKKYNFITFEVKQNENNSFDIEIVGGEVQGKEKNSEEPSAKEKIIQKMEQVHEVMKVEYEYNKNEETANWDVIGHLKLIKFYDKDLTSGLRPVLRLMDNRHVALFKKQRETMPIKMIKVIEVDGIWKDDVNFVPQEGTLLPTDHDEKTVVLLGNDYRHKFERLFKREDVFRLESNNTLTHLKFWQFTTEQTCCLFIIVINLQPIRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G4RZ48</accession>
    <name>G4RZ48_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enhanced RNAI (RNA interference)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">eri-6</name>
        <name evidence="3" type="ORF">C41D11.1</name>
        <name evidence="1" type="ORF">CELE_C41D11.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD64262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001249622.1">
        <property type="nucleotide sequence ID" value="NM_001262693.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4RZ48"/>
    <dbReference type="GeneID" id="172050"/>
    <dbReference type="KEGG" id="cel:CELE_C41D11.1"/>
    <dbReference type="AGR" id="WB:WBGene00016561"/>
    <dbReference type="CTD" id="172050"/>
    <dbReference type="WormBase" id="C41D11.1c">
        <property type="protein sequence ID" value="CE43808"/>
        <property type="gene ID" value="WBGene00016561"/>
        <property type="gene designation" value="eri-6"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">Bristol N2</strain>
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            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2008" name="Nature" volume="455" first="491" last="496">
            <title>Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.</title>
            <authorList>
                <person name="Fischer S.E.J."/>
                <person name="Butler M.D."/>
                <person name="Pan Q."/>
                <person name="Ruvkun G."/>
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            <dbReference type="PubMed" id="18784652"/>
            <dbReference type="DOI" id="10.1038/nature07274"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Bristol N2</strain>
        </source>
    </reference>
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            <authorList>
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                <person name="WormBase"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
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    <dbReference type="AGR" id="WB:WBGene00016561"/>
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            <dbReference type="EMBL" id="ACH90519.1"/>
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    <sequence length="330" mass="39071" checksum="9F43EDB0D592F7F2" modified="2012-01-25" version="2">MTDKENFYSGFFLGRLPGSFDSRFLIKVACFQPGKEERNVFELTTDTKREEDYGEMVHFWVDKGPLQNKSFVRFEENYETFFIHENKMFDRIVHTDKDFYVGVNDLPDSDIYIHPDLGKMIDTRSIVTPGKKYNFITFEVKQNENNSFDIEIVGGEVQGKEKNSEEPSAKEKIIQKMEQVHEVMKVEYEYNKNEETANWDVIGHLKLIKFYDKDLTSGLRPVLRLMDNRHVALFKKQRETMPIKMIKVIEVDGIWKDDVNFVPQEGTLLPTDHDEKTVVLLGNDYRHKFERLFKREDVFRLESNNTLTHLKFWQKTACHSKLELFAHFPK</sequence>
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<entry dataset="Swiss-Prot" created="2016-01-20" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2002" name="J. Mol. Biol." volume="323" first="533" last="549">
            <title>Titins in C.elegans with unusual features: coiled-coil domains, novel regulation of kinase activity and two new possible elastic regions.</title>
            <authorList>
                <person name="Flaherty D.B."/>
                <person name="Gernert K.M."/>
                <person name="Shmeleva N."/>
                <person name="Tang X."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="12381307"/>
            <dbReference type="DOI" id="10.1016/S0022-2836(02)00970-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>IDENTIFICATION OF ISOFORMS E; F; D; H AND I</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>REGION</scope>
        <scope>REPEAT</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2006" name="J. Cell Sci." volume="119" first="239" last="249">
            <title>Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.</title>
            <authorList>
                <person name="Zastrow M.S."/>
                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
                <person name="Wilson K.L."/>
            </authorList>
            <dbReference type="PubMed" id="16410549"/>
            <dbReference type="DOI" id="10.1242/jcs.02728"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2008" name="Biophys. J." volume="95" first="1360" last="1370">
            <title>Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.</title>
            <authorList>
                <person name="Greene D.N."/>
                <person name="Garcia T."/>
                <person name="Sutton R.B."/>
                <person name="Gernert K.M."/>
                <person name="Benian G.M."/>
                <person name="Oberhauser A.F."/>
            </authorList>
            <dbReference type="PubMed" id="18390597"/>
            <dbReference type="DOI" id="10.1529/biophysj.108.130237"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2010" name="J. Mol. Biol." volume="398" first="672" last="689">
            <title>Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.</title>
            <authorList>
                <person name="Forbes J.G."/>
                <person name="Flaherty D.B."/>
                <person name="Ma K."/>
                <person name="Qadota H."/>
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                <person name="Wang K."/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ACTIN AND MYOSIN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>REPEAT</scope>
    </reference>
    <comment type="alternative products">
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        <event type="alternative splicing"/>
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        <isoform>
            <id>G4SLH0-6</id>
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        <isoform>
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        <isoform>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="AAN61521.1"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="W06H8.8g"/>
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    </evidence>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">Bristol N2</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2002" name="J. Mol. Biol." volume="323" first="533" last="549">
            <title>Titins in C.elegans with unusual features: coiled-coil domains, novel regulation of kinase activity and two new possible elastic regions.</title>
            <authorList>
                <person name="Flaherty D.B."/>
                <person name="Gernert K.M."/>
                <person name="Shmeleva N."/>
                <person name="Tang X."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="12381307"/>
            <dbReference type="DOI" id="10.1016/S0022-2836(02)00970-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>IDENTIFICATION OF ISOFORMS E; F; D; H AND I</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>REGION</scope>
        <scope>REPEAT</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2006" name="J. Cell Sci." volume="119" first="239" last="249">
            <title>Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.</title>
            <authorList>
                <person name="Zastrow M.S."/>
                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
                <person name="Wilson K.L."/>
            </authorList>
            <dbReference type="PubMed" id="16410549"/>
            <dbReference type="DOI" id="10.1242/jcs.02728"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2008" name="Biophys. J." volume="95" first="1360" last="1370">
            <title>Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.</title>
            <authorList>
                <person name="Greene D.N."/>
                <person name="Garcia T."/>
                <person name="Sutton R.B."/>
                <person name="Gernert K.M."/>
                <person name="Benian G.M."/>
                <person name="Oberhauser A.F."/>
            </authorList>
            <dbReference type="PubMed" id="18390597"/>
            <dbReference type="DOI" id="10.1529/biophysj.108.130237"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2010" name="J. Mol. Biol." volume="398" first="672" last="689">
            <title>Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.</title>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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                <person name="Gernert K.M."/>
                <person name="Shmeleva N."/>
                <person name="Tang X."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
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            <dbReference type="DOI" id="10.1016/S0022-2836(02)00970-1"/>
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        <scope>TISSUE SPECIFICITY</scope>
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            <authorList>
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                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
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            <dbReference type="PubMed" id="16410549"/>
            <dbReference type="DOI" id="10.1242/jcs.02728"/>
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        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
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        <citation type="journal article" date="2008" name="Biophys. J." volume="95" first="1360" last="1370">
            <title>Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.</title>
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                <person name="Greene D.N."/>
                <person name="Garcia T."/>
                <person name="Sutton R.B."/>
                <person name="Gernert K.M."/>
                <person name="Benian G.M."/>
                <person name="Oberhauser A.F."/>
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            <dbReference type="PubMed" id="18390597"/>
            <dbReference type="DOI" id="10.1529/biophysj.108.130237"/>
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        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
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    <reference evidence="4" key="5">
        <citation type="journal article" date="2010" name="J. Mol. Biol." volume="398" first="672" last="689">
            <title>Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.</title>
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                <person name="Forbes J.G."/>
                <person name="Flaherty D.B."/>
                <person name="Ma K."/>
                <person name="Qadota H."/>
                <person name="Benian G.M."/>
                <person name="Wang K."/>
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        <scope>FUNCTION</scope>
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                <person name="Benian G.M."/>
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        <scope>SUBCELLULAR LOCATION</scope>
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    <reference evidence="4" key="4">
        <citation type="journal article" date="2008" name="Biophys. J." volume="95" first="1360" last="1370">
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                <person name="Garcia T."/>
                <person name="Sutton R.B."/>
                <person name="Gernert K.M."/>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
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        <citation type="journal article" date="2010" name="J. Mol. Biol." volume="398" first="672" last="689">
            <title>Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.</title>
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                <person name="Flaherty D.B."/>
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                <person name="Qadota H."/>
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    <evidence type="ECO:0000312" key="11">
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    </evidence>
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    <evidence type="ECO:0000312" key="13">
        <source>
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        <source>
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        <source>
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<entry dataset="Swiss-Prot" created="2016-01-20" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
        </source>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2002" name="J. Mol. Biol." volume="323" first="533" last="549">
            <title>Titins in C.elegans with unusual features: coiled-coil domains, novel regulation of kinase activity and two new possible elastic regions.</title>
            <authorList>
                <person name="Flaherty D.B."/>
                <person name="Gernert K.M."/>
                <person name="Shmeleva N."/>
                <person name="Tang X."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="12381307"/>
            <dbReference type="DOI" id="10.1016/S0022-2836(02)00970-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>IDENTIFICATION OF ISOFORMS E; F; D; H AND I</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>REGION</scope>
        <scope>REPEAT</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2006" name="J. Cell Sci." volume="119" first="239" last="249">
            <title>Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.</title>
            <authorList>
                <person name="Zastrow M.S."/>
                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
                <person name="Wilson K.L."/>
            </authorList>
            <dbReference type="PubMed" id="16410549"/>
            <dbReference type="DOI" id="10.1242/jcs.02728"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2008" name="Biophys. J." volume="95" first="1360" last="1370">
            <title>Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.</title>
            <authorList>
                <person name="Greene D.N."/>
                <person name="Garcia T."/>
                <person name="Sutton R.B."/>
                <person name="Gernert K.M."/>
                <person name="Benian G.M."/>
                <person name="Oberhauser A.F."/>
            </authorList>
            <dbReference type="PubMed" id="18390597"/>
            <dbReference type="DOI" id="10.1529/biophysj.108.130237"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2010" name="J. Mol. Biol." volume="398" first="672" last="689">
            <title>Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.</title>
            <authorList>
                <person name="Forbes J.G."/>
                <person name="Flaherty D.B."/>
                <person name="Ma K."/>
                <person name="Qadota H."/>
                <person name="Benian G.M."/>
                <person name="Wang K."/>
            </authorList>
            <dbReference type="PubMed" id="20346955"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2010.03.032"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ACTIN AND MYOSIN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>REPEAT</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative promoter"/>
        <event type="alternative splicing"/>
        <isoform>
            <id>G4SLH0-6</id>
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            <id>G4SLH0-5</id>
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            <sequence type="described" ref="VSP_058050 VSP_058051"/>
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        <isoform>
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            <id>G4SLH0-3</id>
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        <isoform>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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        <source>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2002" name="J. Mol. Biol." volume="323" first="533" last="549">
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                <person name="Gernert K.M."/>
                <person name="Shmeleva N."/>
                <person name="Tang X."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
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            <dbReference type="DOI" id="10.1016/S0022-2836(02)00970-1"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>IDENTIFICATION OF ISOFORMS E; F; D; H AND I</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>REGION</scope>
        <scope>REPEAT</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2006" name="J. Cell Sci." volume="119" first="239" last="249">
            <title>Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.</title>
            <authorList>
                <person name="Zastrow M.S."/>
                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
                <person name="Wilson K.L."/>
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            <dbReference type="PubMed" id="16410549"/>
            <dbReference type="DOI" id="10.1242/jcs.02728"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2008" name="Biophys. J." volume="95" first="1360" last="1370">
            <title>Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.</title>
            <authorList>
                <person name="Greene D.N."/>
                <person name="Garcia T."/>
                <person name="Sutton R.B."/>
                <person name="Gernert K.M."/>
                <person name="Benian G.M."/>
                <person name="Oberhauser A.F."/>
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            <dbReference type="PubMed" id="18390597"/>
            <dbReference type="DOI" id="10.1529/biophysj.108.130237"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2010" name="J. Mol. Biol." volume="398" first="672" last="689">
            <title>Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.</title>
            <authorList>
                <person name="Forbes J.G."/>
                <person name="Flaherty D.B."/>
                <person name="Ma K."/>
                <person name="Qadota H."/>
                <person name="Benian G.M."/>
                <person name="Wang K."/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ACTIN AND MYOSIN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>REPEAT</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative promoter"/>
        <event type="alternative splicing"/>
        <isoform>
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        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="W06H8.8f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="W06H8.8g"/>
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    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2016-01-20" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>G4SLH0-8</accession>
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            <fullName evidence="3">Isoform h of Titin homolog</fullName>
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    <gene>
        <name evidence="15" type="primary">ttn-1</name>
        <name evidence="15" type="ORF">W06H8.8</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2002" name="J. Mol. Biol." volume="323" first="533" last="549">
            <title>Titins in C.elegans with unusual features: coiled-coil domains, novel regulation of kinase activity and two new possible elastic regions.</title>
            <authorList>
                <person name="Flaherty D.B."/>
                <person name="Gernert K.M."/>
                <person name="Shmeleva N."/>
                <person name="Tang X."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="12381307"/>
            <dbReference type="DOI" id="10.1016/S0022-2836(02)00970-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>IDENTIFICATION OF ISOFORMS E; F; D; H AND I</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>REGION</scope>
        <scope>REPEAT</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2006" name="J. Cell Sci." volume="119" first="239" last="249">
            <title>Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.</title>
            <authorList>
                <person name="Zastrow M.S."/>
                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
                <person name="Wilson K.L."/>
            </authorList>
            <dbReference type="PubMed" id="16410549"/>
            <dbReference type="DOI" id="10.1242/jcs.02728"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2008" name="Biophys. J." volume="95" first="1360" last="1370">
            <title>Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.</title>
            <authorList>
                <person name="Greene D.N."/>
                <person name="Garcia T."/>
                <person name="Sutton R.B."/>
                <person name="Gernert K.M."/>
                <person name="Benian G.M."/>
                <person name="Oberhauser A.F."/>
            </authorList>
            <dbReference type="PubMed" id="18390597"/>
            <dbReference type="DOI" id="10.1529/biophysj.108.130237"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2010" name="J. Mol. Biol." volume="398" first="672" last="689">
            <title>Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.</title>
            <authorList>
                <person name="Forbes J.G."/>
                <person name="Flaherty D.B."/>
                <person name="Ma K."/>
                <person name="Qadota H."/>
                <person name="Benian G.M."/>
                <person name="Wang K."/>
            </authorList>
            <dbReference type="PubMed" id="20346955"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2010.03.032"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ACTIN AND MYOSIN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>REPEAT</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative promoter"/>
        <event type="alternative splicing"/>
        <isoform>
            <id>G4SLH0-8</id>
            <name evidence="6">h</name>
            <name evidence="3">301kDa_1</name>
            <sequence type="described" ref="VSP_058045 VSP_058056 VSP_058057"/>
        </isoform>
        <isoform>
            <id>G4SLH0-4</id>
            <name evidence="12">d</name>
            <sequence type="described" ref="VSP_058052 VSP_058053 VSP_058054"/>
        </isoform>
        <isoform>
            <id>G4SLH0-7</id>
            <name evidence="10">b</name>
            <sequence type="described" ref="VSP_058047 VSP_058048 VSP_058049"/>
        </isoform>
        <isoform>
            <id>G4SLH0-6</id>
            <name evidence="9">a</name>
            <sequence type="described" ref="VSP_058046 VSP_058047 VSP_058048 VSP_058049"/>
        </isoform>
        <isoform>
            <id>G4SLH0-9</id>
            <name evidence="7">i</name>
            <name evidence="3">301kDa_1</name>
            <sequence type="described" ref="VSP_058055 VSP_058056 VSP_058045 VSP_058057"/>
        </isoform>
        <isoform>
            <id>G4SLH0-2</id>
            <name evidence="13">e</name>
            <sequence type="described" ref="VSP_058056 VSP_058057"/>
        </isoform>
        <isoform>
            <id>G4SLH0-5</id>
            <name evidence="11">c</name>
            <sequence type="described" ref="VSP_058051 VSP_058050"/>
        </isoform>
        <isoform>
            <id>G4SLH0-3</id>
            <name evidence="14">f</name>
            <sequence type="described" ref="VSP_058056 VSP_058055 VSP_058057"/>
        </isoform>
        <isoform>
            <id>G4SLH0-1</id>
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            <sequence type="displayed"/>
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    </comment>
    <comment type="miscellaneous">
        <text evidence="4">Produced by alternative promoter usage.</text>
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    <dbReference type="EC" id="2.7.11.1" evidence="1 2"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
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    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="12381307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18390597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="12381307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="AAN61517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="AAN61520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="AAN61521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="W06H8.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="W06H8.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="W06H8.8c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="W06H8.8d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="W06H8.8e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="W06H8.8f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="W06H8.8g"/>
        </source>
    </evidence>
    <sequence length="2708" mass="300731" checksum="2BBEEBE856FA4571" modified="2012-01-25" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-01-20" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>G4SLH0-9</accession>
    <name>TTN1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform i of Titin homolog</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ttn-1</name>
        <name evidence="15" type="ORF">W06H8.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2002" name="J. Mol. Biol." volume="323" first="533" last="549">
            <title>Titins in C.elegans with unusual features: coiled-coil domains, novel regulation of kinase activity and two new possible elastic regions.</title>
            <authorList>
                <person name="Flaherty D.B."/>
                <person name="Gernert K.M."/>
                <person name="Shmeleva N."/>
                <person name="Tang X."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="12381307"/>
            <dbReference type="DOI" id="10.1016/S0022-2836(02)00970-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>IDENTIFICATION OF ISOFORMS E; F; D; H AND I</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>REGION</scope>
        <scope>REPEAT</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2006" name="J. Cell Sci." volume="119" first="239" last="249">
            <title>Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.</title>
            <authorList>
                <person name="Zastrow M.S."/>
                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
                <person name="Wilson K.L."/>
            </authorList>
            <dbReference type="PubMed" id="16410549"/>
            <dbReference type="DOI" id="10.1242/jcs.02728"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2008" name="Biophys. J." volume="95" first="1360" last="1370">
            <title>Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.</title>
            <authorList>
                <person name="Greene D.N."/>
                <person name="Garcia T."/>
                <person name="Sutton R.B."/>
                <person name="Gernert K.M."/>
                <person name="Benian G.M."/>
                <person name="Oberhauser A.F."/>
            </authorList>
            <dbReference type="PubMed" id="18390597"/>
            <dbReference type="DOI" id="10.1529/biophysj.108.130237"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2010" name="J. Mol. Biol." volume="398" first="672" last="689">
            <title>Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.</title>
            <authorList>
                <person name="Forbes J.G."/>
                <person name="Flaherty D.B."/>
                <person name="Ma K."/>
                <person name="Qadota H."/>
                <person name="Benian G.M."/>
                <person name="Wang K."/>
            </authorList>
            <dbReference type="PubMed" id="20346955"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2010.03.032"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ACTIN AND MYOSIN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>REPEAT</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative promoter"/>
        <event type="alternative splicing"/>
        <isoform>
            <id>G4SLH0-9</id>
            <name evidence="7">i</name>
            <name evidence="3">301kDa_1</name>
            <sequence type="described" ref="VSP_058055 VSP_058057 VSP_058045 VSP_058056"/>
        </isoform>
        <isoform>
            <id>G4SLH0-5</id>
            <name evidence="11">c</name>
            <sequence type="described" ref="VSP_058051 VSP_058050"/>
        </isoform>
        <isoform>
            <id>G4SLH0-3</id>
            <name evidence="14">f</name>
            <sequence type="described" ref="VSP_058055 VSP_058056 VSP_058057"/>
        </isoform>
        <isoform>
            <id>G4SLH0-6</id>
            <name evidence="9">a</name>
            <sequence type="described" ref="VSP_058046 VSP_058048 VSP_058049 VSP_058047"/>
        </isoform>
        <isoform>
            <id>G4SLH0-8</id>
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            <name evidence="3">301kDa_1</name>
            <sequence type="described" ref="VSP_058056 VSP_058045 VSP_058057"/>
        </isoform>
        <isoform>
            <id>G4SLH0-2</id>
            <name evidence="13">e</name>
            <sequence type="described" ref="VSP_058057 VSP_058056"/>
        </isoform>
        <isoform>
            <id>G4SLH0-1</id>
            <name evidence="15">g</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G4SLH0-7</id>
            <name evidence="10">b</name>
            <sequence type="described" ref="VSP_058047 VSP_058049 VSP_058048"/>
        </isoform>
        <isoform>
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    </comment>
    <comment type="miscellaneous">
        <text evidence="4">Produced by alternative promoter usage and alternative splicing of isoform 301kDa_1.</text>
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    <dbReference type="EC" id="2.7.11.1" evidence="1 2"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
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    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="12381307"/>
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    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18390597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="12381307"/>
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    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="AAN61517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="AAN61520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="AAN61521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="W06H8.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="W06H8.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="W06H8.8c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="W06H8.8d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="W06H8.8e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="W06H8.8f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="W06H8.8g"/>
        </source>
    </evidence>
    <sequence length="2693" mass="299097" checksum="1CE4AD2011E8391A" modified="2012-01-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZW0</accession>
    <name>H2KZW0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CaLponIn-liKe proteins</fullName>
        </submittedName>
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    <gene>
        <name evidence="3 5" type="primary">clik-3</name>
        <name evidence="3" type="ORF">CELE_K03E5.2</name>
        <name evidence="5" type="ORF">K03E5.2</name>
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    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD70001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021536.1">
        <property type="nucleotide sequence ID" value="NM_001026365.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZW0"/>
    <dbReference type="PeptideAtlas" id="H2KZW0"/>
    <dbReference type="GeneID" id="186951"/>
    <dbReference type="AGR" id="WB:WBGene00019361"/>
    <dbReference type="CTD" id="186951"/>
    <dbReference type="WormBase" id="K03E5.2b">
        <property type="protein sequence ID" value="CE37655"/>
        <property type="gene ID" value="WBGene00019361"/>
        <property type="gene designation" value="clik-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019361">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZW0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN UNC-87"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD70001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K03E5.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZW0"/>
        </source>
    </evidence>
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</entry>
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    <accession>H2KZW1</accession>
    <name>H2KZW1_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">CaLponIn-liKe proteins</fullName>
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        <name evidence="2 4" type="primary">clik-3</name>
        <name evidence="2" type="ORF">CELE_K03E5.2</name>
        <name evidence="4" type="ORF">K03E5.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD70004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001249366.1">
        <property type="nucleotide sequence ID" value="NM_001262437.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZW1"/>
    <dbReference type="PeptideAtlas" id="H2KZW1"/>
    <dbReference type="GeneID" id="186951"/>
    <dbReference type="AGR" id="WB:WBGene00019361"/>
    <dbReference type="CTD" id="186951"/>
    <dbReference type="WormBase" id="K03E5.2d">
        <property type="protein sequence ID" value="CE43618"/>
        <property type="gene ID" value="WBGene00019361"/>
        <property type="gene designation" value="clik-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2266129_0_0_1"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019361">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZW1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD70004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K03E5.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZW1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11681" checksum="E1AF88694993A2F0" modified="2012-03-21" version="1">MTSPVPPTHQEAGLKIAAVEVPSNEQLERRTRDGKWTLRQLRQTDAMVPLQSGTNQFDSQRGMTGFGTPRDVKGKHLKRIWELEFPEEAADFQQQPVNAQPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZW6</accession>
    <name>H2KZW6_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="4 6" type="primary">kin-36</name>
        <name evidence="4" type="ORF">CELE_T22B11.4</name>
        <name evidence="6" type="ORF">T22B11.4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD70239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023394.1">
        <property type="nucleotide sequence ID" value="NM_001028223.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZW6"/>
    <dbReference type="SMR" id="H2KZW6"/>
    <dbReference type="PaxDb" id="6239-T22B11.4b"/>
    <dbReference type="PeptideAtlas" id="H2KZW6"/>
    <dbReference type="GeneID" id="177234"/>
    <dbReference type="AGR" id="WB:WBGene00020678"/>
    <dbReference type="CTD" id="177234"/>
    <dbReference type="WormBase" id="T22B11.4b">
        <property type="protein sequence ID" value="CE33701"/>
        <property type="gene ID" value="WBGene00020678"/>
        <property type="gene designation" value="kin-36"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SRT2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LEPYWRE"/>
    <dbReference type="OrthoDB" id="5857665at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020678">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZW6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564363" evidence="3">
        <location>
            <begin position="18"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD70239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="T22B11.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZW6"/>
        </source>
    </evidence>
    <sequence length="615" mass="69383" checksum="D99059775370F8BD" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZW7</accession>
    <name>H2KZW7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y38C1AA.1</name>
        <name evidence="4 6" type="ORF">Y38C1AA.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD70243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741285.1">
        <property type="nucleotide sequence ID" value="NM_171239.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZW7"/>
    <dbReference type="SMR" id="H2KZW7"/>
    <dbReference type="PeptideAtlas" id="H2KZW7"/>
    <dbReference type="GeneID" id="176836"/>
    <dbReference type="AGR" id="WB:WBGene00021394"/>
    <dbReference type="CTD" id="176836"/>
    <dbReference type="WormBase" id="Y38C1AA.1a">
        <property type="protein sequence ID" value="CE31641"/>
        <property type="gene ID" value="WBGene00021394"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRTYIGK"/>
    <dbReference type="OrthoDB" id="44277at2759"/>
    <dbReference type="PhylomeDB" id="H2KZW7"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021394">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZW7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753:SF14">
        <property type="entry name" value="MONOACYLGLYCEROL_DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="113"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD70243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y38C1AA.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZW7"/>
        </source>
    </evidence>
    <sequence length="387" mass="44760" checksum="2CBC68C4F5272F91" modified="2012-03-21" version="1">MAISEWIQTLQDVAWPGFLQPHVEVLLLWITWAVDYIDLDYLEYLLWLLLPFFILFIFPIFLVFFIYGCVIFVHIYGHRHQIREAYHTSYWEGARVAIASFWDGVGNVWHGYELRGIENVPDEGSALFIYYHGCLPLDVYYLISKLVIHKNRSLHCVGDKFIFKIPGWRPLCKLFSITSGTVEECTEELKEGNLLCIAPGGVREALFSDPNVYDILWGKRLGFAKVIIGSKTPVIPMFTENCRESFRTPEWGRSFFRWIYEKTKIPLCPIYGGFPVKMITHLGKPIYFDFDTVTPEEVRKTVKREIRMMIKEHQRLPGSVWRGIAQRWSSTSSKKKNSDEPEQAELLQRNGAGTTSPTSDSEDIVVLRRDRSGVEDDDDEVDELGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZW9</accession>
    <name>H2KZW9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">cutl-24</name>
        <name evidence="5" type="ORF">CELE_Y38C1AA.5</name>
        <name evidence="7" type="ORF">Y38C1AA.5</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD70249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023449.1">
        <property type="nucleotide sequence ID" value="NM_001028278.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZW9"/>
    <dbReference type="GeneID" id="176831"/>
    <dbReference type="KEGG" id="cel:CELE_Y38C1AA.5"/>
    <dbReference type="AGR" id="WB:WBGene00021396"/>
    <dbReference type="CTD" id="176831"/>
    <dbReference type="WormBase" id="Y38C1AA.5a">
        <property type="protein sequence ID" value="CE33862"/>
        <property type="gene ID" value="WBGene00021396"/>
        <property type="gene designation" value="cutl-24"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068552at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021396">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZW9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF12">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003563897" evidence="3">
        <location>
            <begin position="18"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="33"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD70249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y38C1AA.5a"/>
        </source>
    </evidence>
    <sequence length="599" mass="66723" checksum="C2B282D66EE50500" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZX0</accession>
    <name>H2KZX0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y38C1AA.1</name>
        <name evidence="4 6" type="ORF">Y38C1AA.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD70257.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZX0"/>
    <dbReference type="SMR" id="H2KZX0"/>
    <dbReference type="AGR" id="WB:WBGene00021394"/>
    <dbReference type="WormBase" id="Y38C1AA.1d">
        <property type="protein sequence ID" value="CE52172"/>
        <property type="gene ID" value="WBGene00021394"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3360204_0_0_1"/>
    <dbReference type="OrthoDB" id="44277at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021394">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZX0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753:SF14">
        <property type="entry name" value="MONOACYLGLYCEROL_DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD70257.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y38C1AA.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZX0"/>
        </source>
    </evidence>
    <sequence length="369" mass="42702" checksum="7183900957143F2C" modified="2017-12-20" version="2">MFQWLHETILNWAHAIYEFVPEYLLWLLLPFFILFIFPIFLVFFIYGCVIFVHIYGHRHQIREAYHTSYWEGARVAIASFWDGVGNVWHGYELRGIENVPDEGSALFIYYHGCLPLDVYYLISKLVIHKNRSLHCVGDKFIFKIPGWRPLCKLFSITSGTVEECTEELKEGNLLCIAPGGVREALFSDPNVYDILWGKRLGFAKVIIGSKTPVIPMFTENCRESFRTPEWGRSFFRWIYEKTKIPLCPIYGGFPVKMITHLGKPIYFDFDTVTPEEVRKTVKREIRMMIKEHQRLPGSVWRGIAQRWSSTSSKKKNSDEPEQAVSIELLQRNGAGTTSPTSDSEDIVVLRRDRSGVEDDDDEVDELGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZX2</accession>
    <name>H2KZX2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat flightless-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">flap-1</name>
        <name evidence="5" type="ORF">CELE_F57B9.7</name>
        <name evidence="7" type="ORF">F57B9.7</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LRRFIP family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD70315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741207.1">
        <property type="nucleotide sequence ID" value="NM_171178.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZX2"/>
    <dbReference type="SMR" id="H2KZX2"/>
    <dbReference type="PeptideAtlas" id="H2KZX2"/>
    <dbReference type="GeneID" id="175964"/>
    <dbReference type="KEGG" id="cel:CELE_F57B9.7"/>
    <dbReference type="AGR" id="WB:WBGene00018998"/>
    <dbReference type="CTD" id="175964"/>
    <dbReference type="WormBase" id="F57B9.7a">
        <property type="protein sequence ID" value="CE31011"/>
        <property type="gene ID" value="WBGene00018998"/>
        <property type="gene designation" value="flap-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018871_0_0_1"/>
    <dbReference type="OrthoDB" id="10028421at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018998">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZX2">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019139">
        <property type="entry name" value="LRRFIP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212:SF0">
        <property type="entry name" value="LD07988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212">
        <property type="entry name" value="LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09738">
        <property type="entry name" value="LRRFIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="113"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD70315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F57B9.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZX2"/>
        </source>
    </evidence>
    <sequence length="353" mass="41129" checksum="6823D5EFA7975C8D" modified="2012-03-21" version="1">MSSYPSSGRRRPITRSEAEERALDKISREAEARMKLKRETREQARQGRYQLLEKKVEEDAEAYRHDTADKVIELQDRVQQVMFLYSQLDNEKSTLLYEVDLLKDELEEKDASLNLSSRECRDLTSEVKALKRTIDALHASQQQLKQEISQRDQLIQENGLCLVEEDPDDEGSESTNNASGEIRSGPYLFKRETIRLVDRVVPGAASLDDKIQKLVDTNKKMRKDYEELEQTIYTQRHARNARDSANVIPNQGVDDVNKDAAKQLAEMKLKMQDLERENTNQQGNVIRMEGQMKRYKSNADVAEKELDELKTQMRQTKKELRDKENALDEQKETNKHLQSRLEKMRMQRTGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZY2</accession>
    <name>H2KZY2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_Y71F9B.9</name>
        <name evidence="5 7" type="ORF">Y71F9B.9</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD70425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122553.2">
        <property type="nucleotide sequence ID" value="NM_001129081.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZY2"/>
    <dbReference type="SMR" id="H2KZY2"/>
    <dbReference type="GeneID" id="171839"/>
    <dbReference type="KEGG" id="cel:CELE_Y71F9B.9"/>
    <dbReference type="AGR" id="WB:WBGene00022130"/>
    <dbReference type="CTD" id="171839"/>
    <dbReference type="WormBase" id="Y71F9B.9b">
        <property type="protein sequence ID" value="CE43611"/>
        <property type="gene ID" value="WBGene00022130"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022130">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZY2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD70425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y71F9B.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZY2"/>
        </source>
    </evidence>
    <sequence length="312" mass="34701" checksum="9799FF2E26DC9B57" modified="2012-03-21" version="1">MSPFGKIAIVGSGLVGSSWATIFASSGYEVQMYDISEKQLQVALENVEKNLRKLDEHGLQRGNLSADEALLRVSTTTSLNEVMKNAIYMQESALEDLNFRIQFYKVIDEIADPTTILASSTSTIPASKFTDGLINKERCLIVHPVNPPLFLPLTELVPAPWTSQDTVDRAAEIMRSVKQEPVKLKKEVLGFVVNRLQFALLAETWRLVADGVIGVNDVDAVMSAGLGPRYAFNGTCETVHLNAFGVRDYFKRYAAGITADMGPIPDFTDEKVINKLEEELEPKMSTLNIRKHQAEREEKLVEIAKLKKDLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZY4</accession>
    <name>H2KZY4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">npr-5</name>
        <name evidence="10" type="ORF">CELE_Y58G8A.4</name>
        <name evidence="12" type="ORF">Y58G8A.4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD70459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024264.1">
        <property type="nucleotide sequence ID" value="NM_001029093.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZY4"/>
    <dbReference type="SMR" id="H2KZY4"/>
    <dbReference type="GeneID" id="190386"/>
    <dbReference type="KEGG" id="cel:CELE_Y58G8A.4"/>
    <dbReference type="AGR" id="WB:WBGene00021983"/>
    <dbReference type="CTD" id="190386"/>
    <dbReference type="WormBase" id="Y58G8A.4a">
        <property type="protein sequence ID" value="CE33345"/>
        <property type="gene ID" value="WBGene00021983"/>
        <property type="gene designation" value="npr-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_6_1_1"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021983">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZY4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="72"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD70459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y58G8A.4a"/>
        </source>
    </evidence>
    <sequence length="397" mass="44536" checksum="092E3CAC4E765F81" modified="2012-03-21" version="1">MVSSAATISTISTTTTPSTISNVITSHSNNGSCIQIAEAIAAQGIDDITVDFYIRSIFTFLYGFLFVLGIFGNGGVLWAVARNKRLQSARNVFLLNLIFTDLILVFTAIPVTPWYAMTKDWAFGSVMCHLVPLSNSCSVFVTSWSLTAISLDKFLHINDPTKQPVSIRQALAITFLIWIVSTLINLPYLMSFEHVDGSFYVQPGETPYCGHFCDEANWQSENSRKIYGTTVMLLQFVVPMAVITYCYFKILQKVSKDMIIQNAQFCQSLTQKQRSDATSRKKKVNYILIAMVVTFIGCWLPLTLLNLVKDFKKEPEWLKRQPFFWAINAHVIAMSLVVWNPLLFFWLTRKQKRSGLSKILNSTEGSKKAGGSGLRGIQLHDLLPTSTHSDRCAGNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZY9</accession>
    <name>H2KZY9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteolipid protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_W02C12.2</name>
        <name evidence="2 4" type="ORF">W02C12.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD70586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255255.1">
        <property type="nucleotide sequence ID" value="NM_001268326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZY9"/>
    <dbReference type="SMR" id="H2KZY9"/>
    <dbReference type="GeneID" id="177155"/>
    <dbReference type="AGR" id="WB:WBGene00020929"/>
    <dbReference type="CTD" id="177155"/>
    <dbReference type="WormBase" id="W02C12.2a">
        <property type="protein sequence ID" value="CE30197"/>
        <property type="gene ID" value="WBGene00020929"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2308571_0_0_1"/>
    <dbReference type="OrthoDB" id="5809348at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020929">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZY9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD70586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="W02C12.2a"/>
        </source>
    </evidence>
    <sequence length="100" mass="11329" checksum="A6E37FEBC3252AAC" modified="2012-03-21" version="1">MLLCCCWPLGKCAKVLACFDTLIVAIFAYKSFIILMETMNHNLHWTTVIAFLFFSMFLICEILGTIFIILAAQKKIARYCIPRLGGVGEHVPVPCLRVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZZ7</accession>
    <name>H2KZZ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_ZC13.1</name>
        <name evidence="8 10" type="ORF">ZC13.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD70623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZZ7"/>
    <dbReference type="PeptideAtlas" id="H2KZZ7"/>
    <dbReference type="AGR" id="WB:WBGene00022502"/>
    <dbReference type="WormBase" id="ZC13.1a">
        <property type="protein sequence ID" value="CE29613"/>
        <property type="gene ID" value="WBGene00022502"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022502">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZZ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044235">
        <property type="entry name" value="RNFT1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860:SF0">
        <property type="entry name" value="LP20373P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860">
        <property type="entry name" value="UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD70623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="ZC13.1a"/>
        </source>
    </evidence>
    <sequence length="340" mass="38940" checksum="1D33D23BAB23E493" modified="2012-03-21" version="1">MDPQQVNNDEIRDNLSRSRSSLSAHFPQIPSSMHDGIQSFFGGSNTEYQNQSTSASFPNDRVSMSSFDENHEATDADGNERDQLLGSQRNIRENLQHFRNSLDNTREGQTVVSITKSIFPFLALFAANFVFDHLYEIFQFIVVYLIFVQADVIVQKMMAGGIANKIFQVVYFFGYTIVTVVYLRNYSLDDFEFSNTFGLNISYFMSGEYKELSMSSTLYGVVMTDTFFKLITILPKSLIVIVPDTYVTTSFKRKVLQLLEYCSQLYRCALPFGPWLRHFLFSNPGSGVMIYFFSISYFSLKVGEVYRYSLSVKKSVGNLLTVFVSYVLSKLILYSFRTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZZ9</accession>
    <name>H2KZZ9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_ZK354.2</name>
        <name evidence="3 5" type="ORF">ZK354.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD70678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741395.1">
        <property type="nucleotide sequence ID" value="NM_171336.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZZ9"/>
    <dbReference type="SMR" id="H2KZZ9"/>
    <dbReference type="PeptideAtlas" id="H2KZZ9"/>
    <dbReference type="GeneID" id="177310"/>
    <dbReference type="AGR" id="WB:WBGene00022705"/>
    <dbReference type="CTD" id="177310"/>
    <dbReference type="WormBase" id="ZK354.2a">
        <property type="protein sequence ID" value="CE15314"/>
        <property type="gene ID" value="WBGene00022705"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_2_5_1"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022705">
        <property type="expression patterns" value="Expressed in material anatomical entity and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZZ9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002080">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD70678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="ZK354.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZZ9"/>
        </source>
    </evidence>
    <sequence length="390" mass="44412" checksum="A7C1D4DC91A5576E" modified="2012-03-21" version="1">MTSVGPGPPQKELIRAQNGTYEVTKPLATGTFGSIYKAKRESDGKFFAVKCEALNMKSSLLRQMSVVLASIHYPSPFFTTIEERGTVPNRFLFIVMPLYGENLFDLMMNTNKDRKFSMATGLHLAEQTLTAIRDLHRNGFIHRDIKPSHFCIGREVDGQHHQVYLLDFGLCKRPRFAKKNDEAEEQMRKNAIHYRGVVKYASVHAHQGKNLGYKDDMESWWYMVLEFFLGALPWALLNKESEQDVLHLKRRITAPMVAAVWRTTPETTAGFFDLLTVIREPKDVAEFVEYDRIADGIQKLFEKSKSNTQEPPDWDCMTDYKGPGYQQVPMIAPPEVGLKPEMDFGKSDPGAGGGSVEQPKKEEVDKKKKKKKKTKKKGKNNKTISVEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K8F7W9</accession>
    <name>K8F7W9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_M195.2</name>
        <name evidence="1 3" type="ORF">M195.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCO25626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263665.1">
        <property type="nucleotide sequence ID" value="NM_001276736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K8F7W9"/>
    <dbReference type="PeptideAtlas" id="K8F7W9"/>
    <dbReference type="GeneID" id="174337"/>
    <dbReference type="AGR" id="WB:WBGene00010948"/>
    <dbReference type="CTD" id="174337"/>
    <dbReference type="WormBase" id="M195.2c">
        <property type="protein sequence ID" value="CE47909"/>
        <property type="gene ID" value="WBGene00010948"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051069_0_0_1"/>
    <dbReference type="OrthoDB" id="5849845at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010948">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="K8F7W9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33750:SF3">
        <property type="entry name" value="ACTIVATED IN BLOCKED UNFOLDED PROTEIN RESPONSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33750">
        <property type="entry name" value="PROTEIN CBG02727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCO25626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="M195.2c"/>
        </source>
    </evidence>
    <sequence length="148" mass="15252" checksum="9CC2506AE40F8071" modified="2013-02-06" version="1">MAQCQTGCANSCAQLSPQPTEGCPTNCRNTCNEVCAPTVASQPSTQAPQSYPVLLDPQQRCSSECQSVCQLACVTQKSAPPSSCLDKCSPQCDSACTSPQVQRNSAQLFTPSADQAPASSAQPIKINISLAPLKPSASTSSSPSPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>K8F7X2</accession>
    <name>K8F7X2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tbc-9</name>
        <name evidence="5" type="ORF">CELE_Y45F10A.6</name>
        <name evidence="7" type="ORF">Y45F10A.6</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
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    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCO25631.1"/>
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        <property type="nucleotide sequence ID" value="NM_001276877.3"/>
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        <property type="protein sequence ID" value="CE47910"/>
        <property type="gene ID" value="WBGene00012868"/>
        <property type="gene designation" value="tbc-9"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <dbReference type="Bgee" id="WBGene00012868">
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        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00566">
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        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="784"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="237"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCO25631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y45F10A.6d"/>
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    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="K8F7X2"/>
        </source>
    </evidence>
    <sequence length="1058" mass="120404" checksum="D666F58572C9CC76" modified="2013-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>K8F7Z0</accession>
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        <recommendedName>
            <fullName evidence="3">Coronin-7</fullName>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
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    <comment type="function">
        <text evidence="8">F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat coronin family.</text>
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        <property type="nucleotide sequence ID" value="NM_001276805.5"/>
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    <dbReference type="AGR" id="WB:WBGene00004075"/>
    <dbReference type="CTD" id="176784"/>
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        <property type="protein sequence ID" value="CE47850"/>
        <property type="gene ID" value="WBGene00004075"/>
        <property type="gene designation" value="pod-1"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
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    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
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            <end position="110"/>
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    <feature type="domain" description="DUF1899" evidence="10">
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            <end position="659"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1003"/>
            <end position="1101"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1089"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCO25661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="Y76A2B.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="K8F7Z0"/>
        </source>
    </evidence>
    <sequence length="1101" mass="120671" checksum="6F08A9D1773CAE6D" modified="2013-02-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-10-01" modified="2026-01-28" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>P37806-2</accession>
    <name>UNC87_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Protein unc-87</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Uncoordinated protein 87</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">unc-87</name>
        <name type="ORF">F08B6.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Cell Biol." volume="127" first="71" last="78">
            <title>The Caenorhabditis elegans UNC-87 protein is essential for maintenance, but not assembly, of bodywall muscle.</title>
            <authorList>
                <person name="Goetinck S."/>
                <person name="Waterston R.H."/>
            </authorList>
            <dbReference type="PubMed" id="7929572"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ALA-207</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1994" name="J. Cell Biol." volume="127" first="79" last="93">
            <title>The Caenorhabditis elegans muscle-affecting gene unc-87 encodes a novel thin filament-associated protein.</title>
            <authorList>
                <person name="Goetinck S.D."/>
                <person name="Waterston R.H."/>
            </authorList>
            <dbReference type="PubMed" id="7929573"/>
            <dbReference type="DOI" id="10.1083/jcb.127.1.79"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND B)</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="6306" last="6312">
            <title>UNC-87 is an actin-bundling protein.</title>
            <authorList>
                <person name="Kranewitter W.J."/>
                <person name="Ylanne J."/>
                <person name="Gimona M."/>
            </authorList>
            <dbReference type="PubMed" id="11096113"/>
            <dbReference type="DOI" id="10.1074/jbc.M009561200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>INTERACTION WITH F-ACTIN</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="J. Cell Sci." volume="120" first="3022" last="3033">
            <title>UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics.</title>
            <authorList>
                <person name="Yamashiro S."/>
                <person name="Gimona M."/>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="17684058"/>
            <dbReference type="DOI" id="10.1242/jcs.013516"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF ALA-207</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="Mol. Biol. Cell" volume="26" first="1687" last="1698">
            <title>UNC-87 isoforms, Caenorhabditis elegans calponin-related proteins, interact with both actin and myosin and regulate actomyosin contractility.</title>
            <authorList>
                <person name="Ono K."/>
                <person name="Obinata T."/>
                <person name="Yamashiro S."/>
                <person name="Liu Z."/>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="25717181"/>
            <dbReference type="DOI" id="10.1091/mbc.E14-10-1483"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MYOSIN AND F-ACTIN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a negative regulator of myosin-dependent contractility of smooth muscle-like cells in the somatic gonad.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P37806-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_020109"/>
        </isoform>
        <isoform>
            <id>P37806-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_000757 VSP_020110"/>
        </isoform>
        <isoform>
            <id>P37806-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021093.1">
        <property type="nucleotide sequence ID" value="NM_001025922.6"/>
    </dbReference>
    <dbReference type="WormBase" id="F08B6.4b">
        <property type="protein sequence ID" value="CE27922"/>
        <property type="gene ID" value="WBGene00006819"/>
        <property type="gene designation" value="unc-87"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="25717181"/>
        </source>
    </evidence>
    <sequence length="374" mass="41576" checksum="5F8BE6E70D1BA71E" modified="2006-09-05" version="3">MPPTEDQVVAEEQPNATMETKVTGQGQPKRVGRWTLAQLRQTDGIIPSQAGWNKGDSQKLMTNFGTPRNTNTRVKSENLQEIPEDIANRTHGEVRLQSGTNKYCSQRGMTGFGSGRDVCREGVRVAQNPADLAELPEEKIRMSEGIVRLQAGTNKYDSQKGMTGFGTGRRETTKMVDSKHPEYDHEKPDQSEIPLQSGTNKFASQKGMTGFGTARRETTKMVDSNHPDYSHECSIDQTTIPSQMGSNQYASQKGMTGFGQPRWEVLDPSISWQNRKSQGMVRLQSGTNRFASQAGMIGFGTCRNTTFEAEGGELPYEAMKVSETIIPSQAGWNKGDSQKKMTSFGAPRDVKGKHLKRIWELEYPEEAEISLDRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-10-01" modified="2026-01-28" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>P37806-3</accession>
    <name>UNC87_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Protein unc-87</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Uncoordinated protein 87</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">unc-87</name>
        <name type="ORF">F08B6.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Cell Biol." volume="127" first="71" last="78">
            <title>The Caenorhabditis elegans UNC-87 protein is essential for maintenance, but not assembly, of bodywall muscle.</title>
            <authorList>
                <person name="Goetinck S."/>
                <person name="Waterston R.H."/>
            </authorList>
            <dbReference type="PubMed" id="7929572"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ALA-207</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1994" name="J. Cell Biol." volume="127" first="79" last="93">
            <title>The Caenorhabditis elegans muscle-affecting gene unc-87 encodes a novel thin filament-associated protein.</title>
            <authorList>
                <person name="Goetinck S.D."/>
                <person name="Waterston R.H."/>
            </authorList>
            <dbReference type="PubMed" id="7929573"/>
            <dbReference type="DOI" id="10.1083/jcb.127.1.79"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND B)</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="6306" last="6312">
            <title>UNC-87 is an actin-bundling protein.</title>
            <authorList>
                <person name="Kranewitter W.J."/>
                <person name="Ylanne J."/>
                <person name="Gimona M."/>
            </authorList>
            <dbReference type="PubMed" id="11096113"/>
            <dbReference type="DOI" id="10.1074/jbc.M009561200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>INTERACTION WITH F-ACTIN</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="J. Cell Sci." volume="120" first="3022" last="3033">
            <title>UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics.</title>
            <authorList>
                <person name="Yamashiro S."/>
                <person name="Gimona M."/>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="17684058"/>
            <dbReference type="DOI" id="10.1242/jcs.013516"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF ALA-207</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="Mol. Biol. Cell" volume="26" first="1687" last="1698">
            <title>UNC-87 isoforms, Caenorhabditis elegans calponin-related proteins, interact with both actin and myosin and regulate actomyosin contractility.</title>
            <authorList>
                <person name="Ono K."/>
                <person name="Obinata T."/>
                <person name="Yamashiro S."/>
                <person name="Liu Z."/>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="25717181"/>
            <dbReference type="DOI" id="10.1091/mbc.E14-10-1483"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MYOSIN AND F-ACTIN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P37806-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P37806-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_020109"/>
        </isoform>
        <isoform>
            <id>P37806-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020110 VSP_000757"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="544" mass="60446" checksum="712180544787BDE1" modified="2006-09-05" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="176" xmlns="https://uniprot.org/uniprot">
    <accession>P90925-2</accession>
    <name>PH4H_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform b of Phenylalanine-4-hydroxylase</fullName>
            <shortName>PAH</shortName>
            <ecNumber evidence="1 2">1.14.16.1</ecNumber>
            <ecNumber evidence="1">1.14.16.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Biogenic amine synthesis protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Phe-4-monooxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tryptophan 5-monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pah-1</name>
        <name evidence="5" type="synonym">bas-2</name>
        <name evidence="5" type="ORF">K08F8.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1999" name="J. Neurogenet." volume="13" first="157" last="180">
            <title>A phenylalanine hydroxylase gene from the nematode C. elegans is expressed in the hypodermis.</title>
            <authorList>
                <person name="Loer C.M."/>
                <person name="Davidson B."/>
                <person name="Mckerrow J."/>
            </authorList>
            <dbReference type="PubMed" id="10928216"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="FASEB J." volume="22" first="3046" last="3058">
            <title>Anabolic function of phenylalanine hydroxylase in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Calvo A.C."/>
                <person name="Pey A.L."/>
                <person name="Ying M."/>
                <person name="Loer C.M."/>
                <person name="Martinez A."/>
            </authorList>
            <dbReference type="PubMed" id="18460651"/>
            <dbReference type="DOI" id="10.1096/fj.08-108522"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBUNIT</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2008" name="J. Biol. Chem." volume="283" first="9127" last="9135">
            <title>The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia.</title>
            <authorList>
                <person name="Fisher A.L."/>
                <person name="Page K.E."/>
                <person name="Lithgow G.J."/>
                <person name="Nash L."/>
            </authorList>
            <dbReference type="PubMed" id="18227072"/>
            <dbReference type="DOI" id="10.1074/jbc.m708341200"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P90925-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_059801"/>
        </isoform>
        <isoform>
            <id>P90925-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="1 2"/>
    <dbReference type="EC" id="1.14.16.4" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001254184.1">
        <property type="nucleotide sequence ID" value="NM_001267255.3"/>
    </dbReference>
    <dbReference type="WormBase" id="K08F8.4b">
        <property type="protein sequence ID" value="CE47563"/>
        <property type="gene ID" value="WBGene00000240"/>
        <property type="gene designation" value="pah-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="10928216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18460651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="10928216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="K08F8.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="K08F8.4b"/>
        </source>
    </evidence>
    <sequence length="453" mass="51829" checksum="88FCD6DE4DE08034" modified="2000-05-30" version="2">MNIDEIRKKYAMESYVADVNADIGKTTIVFTLREKAGALAETLKLFQAHDVNLSHIESRPSKTHEGCYEVLVEFAEAEDHRKIEGVIEHFQQKAEKKVLVQDWNTKNKQNKDSVPWFPQKINDIDQFANRILSYGAELDADHPGFKDMTYRERRKFFADIAFNFKHGDKIPTITYTDEEIATWRTVYNELTVMYPKNACQEFNYIFPLLQQNCGFGPDRIPQLQDVSDFLKDCTGYTIRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSAPKYTPEPDICHELLGHVPLFADVEFAQFSQEIGLASLGAPDDVIEKLATLYWFTIEFGICQQDGEKKAYGAGLLSSFGELQYALSDKPEVVDFDPAVCCVTKYPITEYQPKYFLAESFASAKNKLKSWAATINRPFQIRYNAYTQRVEILDKVAALQRLARDIRSDISTLEEALGKVNNLKMK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2026-01-28" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>Q17423-2</accession>
    <name>CREC_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Crescerin-like protein che-12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">che-12</name>
        <name evidence="3" type="ORF">B0024.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Genetics" volume="178" first="989" last="1002">
            <title>The conserved proteins CHE-12 and DYF-11 are required for sensory cilium function in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Bacaj T."/>
                <person name="Lu Y."/>
                <person name="Shaham S."/>
            </authorList>
            <dbReference type="PubMed" id="18245347"/>
            <dbReference type="DOI" id="10.1534/genetics.107.082453"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="Mol. Biol. Cell" volume="26" first="4248" last="4264">
            <title>Crescerin uses a TOG domain array to regulate microtubules in the primary cilium.</title>
            <authorList>
                <person name="Das A."/>
                <person name="Dickinson D.J."/>
                <person name="Wood C.C."/>
                <person name="Goldstein B."/>
                <person name="Slep K.C."/>
            </authorList>
            <dbReference type="PubMed" id="26378256"/>
            <dbReference type="DOI" id="10.1091/mbc.E15-08-0603"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF PHE-34; ALA-281; TRP-815 AND TRP-1073</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="G3 (Bethesda)" volume="6" first="1475" last="1487">
            <title>A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Neal S.J."/>
                <person name="Park J."/>
                <person name="DiTirro D."/>
                <person name="Yoon J."/>
                <person name="Shibuya M."/>
                <person name="Choi W."/>
                <person name="Schroeder F.C."/>
                <person name="Butcher R.A."/>
                <person name="Kim K."/>
                <person name="Sengupta P."/>
            </authorList>
            <dbReference type="PubMed" id="26976437"/>
            <dbReference type="DOI" id="10.1534/g3.115.026450"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 645-TRP--ARG-1282</scope>
    </reference>
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            <id>Q17423-1</id>
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        <source>
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        <source>
            <dbReference type="WormBase" id="B0024.8b"/>
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        <source>
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        <source>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Genetics" volume="178" first="989" last="1002">
            <title>The conserved proteins CHE-12 and DYF-11 are required for sensory cilium function in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Bacaj T."/>
                <person name="Lu Y."/>
                <person name="Shaham S."/>
            </authorList>
            <dbReference type="PubMed" id="18245347"/>
            <dbReference type="DOI" id="10.1534/genetics.107.082453"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="Mol. Biol. Cell" volume="26" first="4248" last="4264">
            <title>Crescerin uses a TOG domain array to regulate microtubules in the primary cilium.</title>
            <authorList>
                <person name="Das A."/>
                <person name="Dickinson D.J."/>
                <person name="Wood C.C."/>
                <person name="Goldstein B."/>
                <person name="Slep K.C."/>
            </authorList>
            <dbReference type="PubMed" id="26378256"/>
            <dbReference type="DOI" id="10.1091/mbc.E15-08-0603"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF PHE-34; ALA-281; TRP-815 AND TRP-1073</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="G3 (Bethesda)" volume="6" first="1475" last="1487">
            <title>A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Neal S.J."/>
                <person name="Park J."/>
                <person name="DiTirro D."/>
                <person name="Yoon J."/>
                <person name="Shibuya M."/>
                <person name="Choi W."/>
                <person name="Schroeder F.C."/>
                <person name="Butcher R.A."/>
                <person name="Kim K."/>
                <person name="Sengupta P."/>
            </authorList>
            <dbReference type="PubMed" id="26976437"/>
            <dbReference type="DOI" id="10.1534/g3.115.026450"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 645-TRP--ARG-1282</scope>
    </reference>
    <comment type="alternative products">
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        <isoform>
            <id>Q17423-2</id>
            <name evidence="4">b</name>
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        <isoform>
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    </evidence>
    <evidence type="ECO:0000305" key="2"/>
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        <source>
            <dbReference type="WormBase" id="B0024.8a"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="B0024.8b"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="B0024.8c"/>
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    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="B0024.8d"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="173" xmlns="https://uniprot.org/uniprot">
    <accession>Q18420</accession>
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        <submittedName>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
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    <dbReference type="RefSeq" id="NP_001379161.1">
        <property type="nucleotide sequence ID" value="NM_001392634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18420"/>
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    <dbReference type="UCSC" id="C34B4.1b">
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    <dbReference type="WormBase" id="C34B4.1a">
        <property type="protein sequence ID" value="CE40604"/>
        <property type="gene ID" value="WBGene00003143"/>
        <property type="gene designation" value="max-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001626_2_0_1"/>
    <dbReference type="OrthoDB" id="6285196at2759"/>
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    <dbReference type="Bgee" id="WBGene00003143">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18420">
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        <location>
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    <feature type="domain" description="PH" evidence="4">
        <location>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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    <feature type="region of interest" description="Disordered" evidence="3">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50057"/>
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        <source>
            <dbReference type="PROSITE" id="PS51016"/>
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        <source>
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<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="165" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="277"/>
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    </feature>
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            <begin position="85"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
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    </feature>
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            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="CCD65071.1"/>
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    </evidence>
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</entry>
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        <location>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51076"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAA91752.4"/>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
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        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB01166.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F23B12.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q19751"/>
        </source>
    </evidence>
    <sequence length="137" mass="15400" checksum="D913A25844C04ADA" modified="2007-08-21" version="2">MSRIIPVADGFQRGSSGDAQVTAAPTTQATFTQQPTFQQTFRPIPARPRQRIVAQQPQSPFNRQNVFISRRRGQSNSFAAQRQNVFQQPQPAFGGGQCADRDPQGRCSQWRQFCASPSHQQYLTAFCARTCGLCRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q19780</accession>
    <name>Q19780_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Abnormal cell migration protein 18-like fibronectin type I domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">CELE_F25E2.2</name>
        <name evidence="3 5" type="ORF">F25E2.2</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256979.1">
        <property type="nucleotide sequence ID" value="NM_001270050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19780"/>
    <dbReference type="PeptideAtlas" id="Q19780"/>
    <dbReference type="GeneID" id="180428"/>
    <dbReference type="UCSC" id="F25E2.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017780"/>
    <dbReference type="CTD" id="180428"/>
    <dbReference type="WormBase" id="F25E2.2b">
        <property type="protein sequence ID" value="CE43807"/>
        <property type="gene ID" value="WBGene00017780"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1670937_0_0_1"/>
    <dbReference type="OrthoDB" id="5780467at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017780">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q19780">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36493:SF3">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36493">
        <property type="entry name" value="NEUROBLAST DIFFERENTIATION-ASSOCIATED PROTEIN AHNAK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187121" evidence="1">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD69989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F25E2.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q19780"/>
        </source>
    </evidence>
    <sequence length="158" mass="17856" checksum="4988AEF863DB135E" modified="2012-01-25" version="3">MNIVTFLLFGIFPLSAAISPINLENCNPGSYFVENYIKYQCYQSGSVKGYNIAGCQPSNDLTGVTLQQWETHNEKWFKYHCVIDGTNAQYSVKTCLDPVGEVLPVGKTRSFPDGETFTCFIERNKVKLNHQTSEQYMIYHAIVPANYVIVRPNGDVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>Q19784</accession>
    <name>Q19784_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F25F2.1</name>
        <name evidence="3 5" type="ORF">F25F2.1</name>
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    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAA84659.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022549.2">
        <property type="nucleotide sequence ID" value="NM_001027378.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19784"/>
    <dbReference type="SMR" id="Q19784"/>
    <dbReference type="GeneID" id="175589"/>
    <dbReference type="KEGG" id="cel:CELE_F25F2.1"/>
    <dbReference type="UCSC" id="F25F2.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009115"/>
    <dbReference type="CTD" id="175589"/>
    <dbReference type="WormBase" id="F25F2.1a">
        <property type="protein sequence ID" value="CE41396"/>
        <property type="gene ID" value="WBGene00009115"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017328_0_0_1"/>
    <dbReference type="OrthoDB" id="2687620at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009115">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q19784">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001135">
        <property type="entry name" value="Protein CBG16501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="162"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA84659.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F25F2.1a"/>
        </source>
    </evidence>
    <sequence length="581" mass="66673" checksum="83209896BF5CE1AE" modified="2007-09-11" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q19790</accession>
    <name>Q19790_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">dur-1</name>
        <name evidence="3" type="ORF">CELE_F25H8.5</name>
        <name evidence="5" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA93285.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21369">
        <property type="entry name" value="T21369"/>
    </dbReference>
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        <property type="entry name" value="T21370"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_501786.2">
        <property type="nucleotide sequence ID" value="NM_069385.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19790"/>
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    <dbReference type="IntAct" id="Q19790">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q19790"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="UCSC" id="F25H8.5a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5a">
        <property type="protein sequence ID" value="CE35290"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019234_0_0_1"/>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q19790">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF47">
        <property type="entry name" value="DAUER UP-REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187204" evidence="2">
        <location>
            <begin position="18"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA93285.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F25H8.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q19790"/>
        </source>
    </evidence>
    <sequence length="780" mass="79512" checksum="A651EA8C965ADB18" modified="2004-07-05" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXT7</accession>
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        <submittedName>
            <fullName evidence="2">Zinc finger CCCH domain-containing protein 15 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="2 4" type="ORF">F27D4.4</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ85748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040657.1">
        <property type="nucleotide sequence ID" value="NM_001047192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXT7"/>
    <dbReference type="GeneID" id="172538"/>
    <dbReference type="UCSC" id="F27D4.4a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009189"/>
    <dbReference type="CTD" id="172538"/>
    <dbReference type="WormBase" id="F27D4.4b">
        <property type="protein sequence ID" value="CE40046"/>
        <property type="gene ID" value="WBGene00009189"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042870_1_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009189">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXT7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ85748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F27D4.4b"/>
        </source>
    </evidence>
    <sequence length="25" mass="2931" checksum="047550E5B9E12DE6" modified="2006-04-18" version="1">MAKMDINEDLFDIDEDVENLDSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXT8</accession>
    <name>Q1ZXT8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">clc-15</name>
        <name evidence="2" type="ORF">CELE_F59C6.14</name>
        <name evidence="4" type="ORF">F59C6.14</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ85761.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040670.2">
        <property type="nucleotide sequence ID" value="NM_001047205.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXT8"/>
    <dbReference type="SMR" id="Q1ZXT8"/>
    <dbReference type="GeneID" id="4362998"/>
    <dbReference type="UCSC" id="F59C6.14a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00044792"/>
    <dbReference type="CTD" id="4362998"/>
    <dbReference type="WormBase" id="F59C6.14b">
        <property type="protein sequence ID" value="CE42128"/>
        <property type="gene ID" value="WBGene00044792"/>
        <property type="gene designation" value="clc-15"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132253_0_0_1"/>
    <dbReference type="OrthoDB" id="5824524at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044792">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXT8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009545">
        <property type="entry name" value="Claudin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21759:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21759">
        <property type="entry name" value="PROTEIN CBG02235-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06653">
        <property type="entry name" value="Claudin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ85761.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F59C6.14b"/>
        </source>
    </evidence>
    <sequence length="138" mass="15739" checksum="BAFADE024B7FCF5B" modified="2008-03-18" version="2">MNLSIDYDEVTEIPGASPPYSRLIPYPAHADWWFGLTAVMIYLLLVVCTLYMIWTVIQIVMPNRIEFDLKMIVFIDAVFSAIITLMLLIAYCFFAGGFNGKQYLDGFSFGYCFWLAVISSVVSFGVLLMNGLSWFRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXU2</accession>
    <name>Q1ZXU2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">add-2</name>
        <name evidence="7" type="ORF">CELE_F57F5.4</name>
        <name evidence="9" type="ORF">F57F5.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAJ85747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041131.1">
        <property type="nucleotide sequence ID" value="NM_001047666.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXU2"/>
    <dbReference type="SMR" id="Q1ZXU2"/>
    <dbReference type="PeptideAtlas" id="Q1ZXU2"/>
    <dbReference type="GeneID" id="179647"/>
    <dbReference type="UCSC" id="F57F5.4a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000073"/>
    <dbReference type="CTD" id="179647"/>
    <dbReference type="WormBase" id="F57F5.4b">
        <property type="protein sequence ID" value="CE40075"/>
        <property type="gene ID" value="WBGene00000073"/>
        <property type="gene designation" value="add-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_447074_0_0_1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000073">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXU2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000013">
        <property type="entry name" value="Class II aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005451">
        <property type="entry name" value="PRK07044.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF42">
        <property type="entry name" value="ADDUCIN-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="6">
        <location>
            <begin position="42"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ85747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F57F5.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q1ZXU2"/>
        </source>
    </evidence>
    <sequence length="294" mass="32239" checksum="E6DA5FEEBDF924A7" modified="2006-04-18" version="1">MFSAGVISTATVPAPMFHPHITPIADLKDDDGYDPEELTQRNKLASLYRLVDLFRWSQGIYNHITVRVSTDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGGSTNFGVNQAGYVLHSAIHNGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQESMIVGDVGYHEYRGILIDEAERALLVRDLGDRNVMILRNHGFVVCGESIEHALSLTYHLIIACETQIRTVPGGNTDNVHFPAQSAIKQVYKVASQGGGGVNRQNGHVNSMQWKKGELEWQAYMRQLDAQGYVTGNVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXU5</accession>
    <name>Q1ZXU5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C26C6.4</name>
        <name evidence="2" type="ORF">CELE_C26C6.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ85752.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040639.2">
        <property type="nucleotide sequence ID" value="NM_001047174.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXU5"/>
    <dbReference type="GeneID" id="182933"/>
    <dbReference type="UCSC" id="C26C6.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007739"/>
    <dbReference type="CTD" id="182933"/>
    <dbReference type="WormBase" id="C26C6.4b">
        <property type="protein sequence ID" value="CE43149"/>
        <property type="gene ID" value="WBGene00007739"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055011_0_0_1"/>
    <dbReference type="OrthoDB" id="5838555at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007739">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXU5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967">
        <property type="entry name" value="GROUNDHOG (HEDGEHOG-LIKE FAMILY)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967:SF24">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ85752.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C26C6.4b"/>
        </source>
    </evidence>
    <sequence length="311" mass="36863" checksum="3E7F084478CA816B" modified="2008-12-16" version="2">MPKPPYIIFYDSSNLDIFLNHICNLEFIPGALSRLVAISFDTPSHLILKEKYPNIPSVVINLDSIKKTLPESYENRRYIIYQLVLLTRARICASLALRGISFWAMQQDTLWVENFDSMDLENRYPDEYMLFDTVGNEQFGEYDRMFGWICGSTFFVRGNPTTYQFFYQIDSFMRSHQSPDSSIMTYLCGHRNYRCHRLPRWIISSSDYFRGTRETTPVMIQVDSDQTDETKMESFQRANFIFRHDNGTCDRKSVHKLRDAVRLAFPEKLKLLDQSPYGESMFTQLHYMYKHIFNIDRYNNKVFLTVHYTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2025-10-08" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXU6</accession>
    <name>Q1ZXU6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-GlycoProtein related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">pgp-6</name>
        <name evidence="11" type="ORF">CELE_T21E8.1</name>
        <name evidence="13" type="ORF">T21E8.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAJ85767.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041288.2">
        <property type="nucleotide sequence ID" value="NM_001047823.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXU6"/>
    <dbReference type="SMR" id="Q1ZXU6"/>
    <dbReference type="PeptideAtlas" id="Q1ZXU6"/>
    <dbReference type="GeneID" id="181278"/>
    <dbReference type="UCSC" id="T21E8.1b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004000"/>
    <dbReference type="CTD" id="181278"/>
    <dbReference type="WormBase" id="T21E8.1b">
        <property type="protein sequence ID" value="CE40819"/>
        <property type="gene ID" value="WBGene00004000"/>
        <property type="gene designation" value="pgp-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004000">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXU6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000916">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000265">
        <property type="entry name" value="p-GlycoProtein related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002283">
        <property type="entry name" value="p-GlycoProtein related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="858"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="322"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="637"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="957"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ85767.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="T21E8.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q1ZXU6"/>
        </source>
    </evidence>
    <sequence length="1204" mass="134208" checksum="8CBBF912F6AF8754" modified="2007-05-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXU8</accession>
    <name>Q1ZXU8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">acl-5</name>
        <name evidence="16" type="ORF">CELE_R07E3.5</name>
        <name evidence="18" type="ORF">R07E3.5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAJ85773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041283.1">
        <property type="nucleotide sequence ID" value="NM_001047818.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXU8"/>
    <dbReference type="SMR" id="Q1ZXU8"/>
    <dbReference type="PeptideAtlas" id="Q1ZXU8"/>
    <dbReference type="GeneID" id="181241"/>
    <dbReference type="UCSC" id="R07E3.5a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011106"/>
    <dbReference type="CTD" id="181241"/>
    <dbReference type="WormBase" id="R07E3.5b">
        <property type="protein sequence ID" value="CE40105"/>
        <property type="gene ID" value="WBGene00011106"/>
        <property type="gene designation" value="acl-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031080_0_1_1"/>
    <dbReference type="OrthoDB" id="10051137at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011106">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXU8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF53">
        <property type="entry name" value="PHOSPHOLIPID_GLYCEROL ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
        <location>
            <begin position="181"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ85773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="R07E3.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="Q1ZXU8"/>
        </source>
    </evidence>
    <sequence length="455" mass="52199" checksum="9DA3D0FD8B0C0821" modified="2006-04-18" version="1">MPEDFQHKKPRRSSSASDLGIINREKSDIIDAKLHETNVPEAKQTTVSVLVDDTLDFITAGMEAVIEDQVTNRFSAAQLPSWNLLSRTKYSFHFFNWQLTLLWIAGFMFRYYVLVPCRIALFGIAIVLMIVSTSIIGLVPNAKVRKFLNRRCMLMCMRIYSRAFSSVIRFHDKENRANKGGICVANHTSPIDVMVLSCDNCYAMIGQKQAGFLGFLQTTLSRSEHHIWFERGEAGDRAKVMDRMREHVNDENKLPIIIFPEGTCINNTSVMMFKKGSFEIGSTIYPIAVKYDTRLTDAFWNSSAQSYGRYLWSMMTSWAIICDVWYLPAMTRGENEDSISFAKRVKRAIAKKGGLIDLEWDGALKRERVSSKLVTLQQKLYFERLARTTTLNAMLEEKSSDILNIMQGISEEERDELLKQIDEQDDEEEMIRKISSLKPKFKIGDHDADEHIKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXU9</accession>
    <name>Q1ZXU9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein Rheb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_ZK669.5</name>
        <name evidence="3 5" type="ORF">ZK669.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAJ85783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040833.1">
        <property type="nucleotide sequence ID" value="NM_001047368.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXU9"/>
    <dbReference type="SMR" id="Q1ZXU9"/>
    <dbReference type="PeptideAtlas" id="Q1ZXU9"/>
    <dbReference type="GeneID" id="174280"/>
    <dbReference type="UCSC" id="ZK669.5b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00014055"/>
    <dbReference type="CTD" id="174280"/>
    <dbReference type="WormBase" id="ZK669.5b">
        <property type="protein sequence ID" value="CE40184"/>
        <property type="gene ID" value="WBGene00014055"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1300674_0_0_1"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014055">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXU9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ85783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="ZK669.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q1ZXU9"/>
        </source>
    </evidence>
    <sequence length="176" mass="20371" checksum="66301B44A77B76AD" modified="2006-04-18" version="1">MAPDPTSYDRVFKFLIFGGKSVGKKTLLRSFCTEGDNESIWTSLTVDDEKVLIEATVSQKWEEGMSKEHDAIALVFSTTDVYSFEYTLELYNEIQKSTERIPLVFIENKIDIVEDSQMDKGLVEGEMRKKHKRLYRVSALKEFNVMHPFAYLIEKLTRQKKDLNANESVSENSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q20771</accession>
    <name>Q20771_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F54D5.5</name>
        <name evidence="3 5" type="ORF">F54D5.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAA91332.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T22655">
        <property type="entry name" value="T22655"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q20771"/>
    <dbReference type="SMR" id="Q20771"/>
    <dbReference type="IntAct" id="Q20771">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="MINT" id="Q20771"/>
    <dbReference type="PeptideAtlas" id="Q20771"/>
    <dbReference type="UCSC" id="F54D5.5a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010051"/>
    <dbReference type="WormBase" id="F54D5.5a">
        <property type="protein sequence ID" value="CE36386"/>
        <property type="gene ID" value="WBGene00010051"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052878_0_0_1"/>
    <dbReference type="OrthoDB" id="5838092at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010051">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q20771">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37960:SF3">
        <property type="entry name" value="PROTEIN CBG02859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37960">
        <property type="entry name" value="PROTEIN CBG06493-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA91332.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F54D5.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q20771"/>
        </source>
    </evidence>
    <sequence length="427" mass="48646" checksum="C08FD4EF596EDB5D" modified="2004-07-05" version="4">MAAIIRTLFKSKKSKKGDEENNEDLAREVSNRRSFRAPSTSSSKSQRRAVARFADDGALPATAAYHTTSAPKLRKGPQSCPGGYRDESDVSYESDKYSQKSNSHRRRDVLHQSMRQNYTIDEGRKPSSRRHHSSKSDFRRRGESSEYGSGDPSPVGQYSSRHSHYEDRIEESENDDFSEKAQFAVIERAQQHYMQKYKESEQKRREEKRKLKDMEKECNDAKNAMFHYMNQLDKVKKERDCYRKELSRCKKQLEAFQNSGYDAFHHLRQPQISNPQQYPPPLSMGSYPYMSQSMNASHHMSSNFMNSAPPSSNTPMTMTSGAGESLINPSDVSFLQNSFLQPTSQGLTGMTPPPGGFKVPTNYGDDDRDEVKDYRSELLIETSRSTKEVDSISPSSSADSQVTLLDHSTIDKENRKPPSRPFSMMSI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2026-01-28" version="168" xmlns="https://uniprot.org/uniprot">
    <accession>Q26261-1</accession>
    <name>UNC5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Netrin receptor unc-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Uncoordinated protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">unc-5</name>
        <name evidence="3" type="ORF">B0273.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Cell" volume="71" first="289" last="299">
            <title>UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans.</title>
            <authorList>
                <person name="Leung-Hagesteijn C."/>
                <person name="Spence A.M."/>
                <person name="Stern B.D."/>
                <person name="Zhou Y."/>
                <person name="Su M.-W."/>
                <person name="Hedgecock E.M."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="1384987"/>
            <dbReference type="DOI" id="10.1016/0092-8674(92)90357-I"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND C)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Nature" volume="364" first="327" last="330">
            <title>Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally.</title>
            <authorList>
                <person name="Hamelin M."/>
                <person name="Zhou Y."/>
                <person name="Su M.-W."/>
                <person name="Scott I.M."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="8332188"/>
            <dbReference type="DOI" id="10.1038/364327a0"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Dev. Biol." volume="194" first="72" last="85">
            <title>Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Colavita A."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="9473333"/>
            <dbReference type="DOI" id="10.1006/dbio.1997.8790"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="Development" volume="127" first="585" last="594">
            <title>Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Su M.-W."/>
                <person name="Merz D.C."/>
                <person name="Killeen M.T."/>
                <person name="Zhou Y."/>
                <person name="Zheng H."/>
                <person name="Kramer J.M."/>
                <person name="Hedgecock E.M."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="10631179"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2001" name="Genetics" volume="158" first="1071" last="1080">
            <title>Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivo.</title>
            <authorList>
                <person name="Merz D.C."/>
                <person name="Zheng H."/>
                <person name="Killeen M.T."/>
                <person name="Krizus A."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="11454756"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="40917" last="40925">
            <title>Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.</title>
            <authorList>
                <person name="Tong J."/>
                <person name="Killeen M."/>
                <person name="Steven R."/>
                <person name="Binns K.L."/>
                <person name="Culotti J."/>
                <person name="Pawson T."/>
            </authorList>
            <dbReference type="PubMed" id="11533026"/>
            <dbReference type="DOI" id="10.1074/jbc.M103872200"/>
        </citation>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2002" name="Dev. Biol." volume="251" first="348" last="366">
            <title>UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.</title>
            <authorList>
                <person name="Killeen M."/>
                <person name="Tong J."/>
                <person name="Krizus A."/>
                <person name="Steven R."/>
                <person name="Scott I."/>
                <person name="Pawson T."/>
                <person name="Culotti J."/>
            </authorList>
            <dbReference type="PubMed" id="12435363"/>
            <dbReference type="DOI" id="10.1006/dbio.2002.0825"/>
        </citation>
        <scope>PHOSPHORYLATION AT TYR-510</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF CYS-209; 415-TYR-TYR-416; TYR-445; TYR-467; TYR-510; TYR-566 AND TYR-719</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2005" name="Development" volume="132" first="5161" last="5172">
            <title>SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.</title>
            <authorList>
                <person name="Itoh B."/>
                <person name="Hirose T."/>
                <person name="Takata N."/>
                <person name="Nishiwaki K."/>
                <person name="Koga M."/>
                <person name="Ohshima Y."/>
                <person name="Okada M."/>
            </authorList>
            <dbReference type="PubMed" id="16251208"/>
            <dbReference type="DOI" id="10.1242/dev.02103"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2005" name="Mol. Cell. Biol." volume="25" first="6485" last="6495">
            <title>SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lee J."/>
                <person name="Li W."/>
                <person name="Guan K.L."/>
            </authorList>
            <dbReference type="PubMed" id="16024786"/>
            <dbReference type="DOI" id="10.1128/MCB.25.15.6485-6495.2005"/>
        </citation>
        <scope>INTERACTION WITH SRC-1</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2007" name="Dev. Biol." volume="310" first="44" last="53">
            <title>C. elegans seu-1 encodes novel nuclear proteins that regulate responses to UNC-6/netrin guidance cues.</title>
            <authorList>
                <person name="Zheng H."/>
                <person name="Coudiere L."/>
                <person name="Camia C."/>
                <person name="Colavita A."/>
                <person name="Culotti J.G."/>
                <person name="Merz D.C."/>
            </authorList>
            <dbReference type="PubMed" id="17716643"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.07.014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF CYS-209 AND 311-TRP--PRO-947</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-206</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2009" name="Nat. Neurosci." volume="12" first="150" last="155">
            <title>UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.</title>
            <authorList>
                <person name="MacNeil L.T."/>
                <person name="Hardy W.R."/>
                <person name="Pawson T."/>
                <person name="Wrana J.L."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="19169249"/>
            <dbReference type="DOI" id="10.1038/nn.2256"/>
        </citation>
        <scope>INTERACTION WITH UNC-129</scope>
        <scope>MUTAGENESIS OF 311-TRP--PRO-947</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2013" name="Mol. Cell" volume="50" first="295" last="302">
            <title>C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats.</title>
            <authorList>
                <person name="Buettner F.F."/>
                <person name="Ashikov A."/>
                <person name="Tiemann B."/>
                <person name="Lehle L."/>
                <person name="Bakker H."/>
            </authorList>
            <dbReference type="PubMed" id="23562325"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2013.03.003"/>
        </citation>
        <scope>GLYCOSYLATION AT TRP-305 AND TRP-308</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2014" name="PLoS Genet." volume="10" first="E1004521" last="E1004521">
            <title>EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chan K.K."/>
                <person name="Seetharaman A."/>
                <person name="Bagg R."/>
                <person name="Selman G."/>
                <person name="Zhang Y."/>
                <person name="Kim J."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="25122090"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004521"/>
        </citation>
        <scope>INTERACTION WITH MADD-4</scope>
    </reference>
    <reference key="16">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005446" last="E1005446">
            <title>The Wnt frizzled receptor MOM-5 regulates the UNC-5 Netrin receptor through small GTPase-dependent signaling to determine the polarity of migrating cells.</title>
            <authorList>
                <person name="Levy-Strumpf N."/>
                <person name="Krizus M."/>
                <person name="Zheng H."/>
                <person name="Brown L."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="26292279"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005446"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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    <reference key="1">
        <citation type="journal article" date="1992" name="Cell" volume="71" first="289" last="299">
            <title>UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans.</title>
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            <dbReference type="PubMed" id="1384987"/>
            <dbReference type="DOI" id="10.1016/0092-8674(92)90357-I"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND C)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
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                <person name="Zhou Y."/>
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            </authorList>
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        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
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            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9473333"/>
            <dbReference type="DOI" id="10.1006/dbio.1997.8790"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
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            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="Development" volume="127" first="585" last="594">
            <title>Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Su M.-W."/>
                <person name="Merz D.C."/>
                <person name="Killeen M.T."/>
                <person name="Zhou Y."/>
                <person name="Zheng H."/>
                <person name="Kramer J.M."/>
                <person name="Hedgecock E.M."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="10631179"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
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            <title>Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivo.</title>
            <authorList>
                <person name="Merz D.C."/>
                <person name="Zheng H."/>
                <person name="Killeen M.T."/>
                <person name="Krizus A."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="11454756"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="40917" last="40925">
            <title>Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.</title>
            <authorList>
                <person name="Tong J."/>
                <person name="Killeen M."/>
                <person name="Steven R."/>
                <person name="Binns K.L."/>
                <person name="Culotti J."/>
                <person name="Pawson T."/>
            </authorList>
            <dbReference type="PubMed" id="11533026"/>
            <dbReference type="DOI" id="10.1074/jbc.M103872200"/>
        </citation>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2002" name="Dev. Biol." volume="251" first="348" last="366">
            <title>UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.</title>
            <authorList>
                <person name="Killeen M."/>
                <person name="Tong J."/>
                <person name="Krizus A."/>
                <person name="Steven R."/>
                <person name="Scott I."/>
                <person name="Pawson T."/>
                <person name="Culotti J."/>
            </authorList>
            <dbReference type="PubMed" id="12435363"/>
            <dbReference type="DOI" id="10.1006/dbio.2002.0825"/>
        </citation>
        <scope>PHOSPHORYLATION AT TYR-510</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF CYS-209; 415-TYR-TYR-416; TYR-445; TYR-467; TYR-510; TYR-566 AND TYR-719</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2005" name="Development" volume="132" first="5161" last="5172">
            <title>SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.</title>
            <authorList>
                <person name="Itoh B."/>
                <person name="Hirose T."/>
                <person name="Takata N."/>
                <person name="Nishiwaki K."/>
                <person name="Koga M."/>
                <person name="Ohshima Y."/>
                <person name="Okada M."/>
            </authorList>
            <dbReference type="PubMed" id="16251208"/>
            <dbReference type="DOI" id="10.1242/dev.02103"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2005" name="Mol. Cell. Biol." volume="25" first="6485" last="6495">
            <title>SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lee J."/>
                <person name="Li W."/>
                <person name="Guan K.L."/>
            </authorList>
            <dbReference type="PubMed" id="16024786"/>
            <dbReference type="DOI" id="10.1128/MCB.25.15.6485-6495.2005"/>
        </citation>
        <scope>INTERACTION WITH SRC-1</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2007" name="Dev. Biol." volume="310" first="44" last="53">
            <title>C. elegans seu-1 encodes novel nuclear proteins that regulate responses to UNC-6/netrin guidance cues.</title>
            <authorList>
                <person name="Zheng H."/>
                <person name="Coudiere L."/>
                <person name="Camia C."/>
                <person name="Colavita A."/>
                <person name="Culotti J.G."/>
                <person name="Merz D.C."/>
            </authorList>
            <dbReference type="PubMed" id="17716643"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.07.014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF CYS-209 AND 311-TRP--PRO-947</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-206</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2009" name="Nat. Neurosci." volume="12" first="150" last="155">
            <title>UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.</title>
            <authorList>
                <person name="MacNeil L.T."/>
                <person name="Hardy W.R."/>
                <person name="Pawson T."/>
                <person name="Wrana J.L."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="19169249"/>
            <dbReference type="DOI" id="10.1038/nn.2256"/>
        </citation>
        <scope>INTERACTION WITH UNC-129</scope>
        <scope>MUTAGENESIS OF 311-TRP--PRO-947</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2013" name="Mol. Cell" volume="50" first="295" last="302">
            <title>C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats.</title>
            <authorList>
                <person name="Buettner F.F."/>
                <person name="Ashikov A."/>
                <person name="Tiemann B."/>
                <person name="Lehle L."/>
                <person name="Bakker H."/>
            </authorList>
            <dbReference type="PubMed" id="23562325"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2013.03.003"/>
        </citation>
        <scope>GLYCOSYLATION AT TRP-305 AND TRP-308</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2014" name="PLoS Genet." volume="10" first="E1004521" last="E1004521">
            <title>EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chan K.K."/>
                <person name="Seetharaman A."/>
                <person name="Bagg R."/>
                <person name="Selman G."/>
                <person name="Zhang Y."/>
                <person name="Kim J."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="25122090"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004521"/>
        </citation>
        <scope>INTERACTION WITH MADD-4</scope>
    </reference>
    <reference key="16">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005446" last="E1005446">
            <title>The Wnt frizzled receptor MOM-5 regulates the UNC-5 Netrin receptor through small GTPase-dependent signaling to determine the polarity of migrating cells.</title>
            <authorList>
                <person name="Levy-Strumpf N."/>
                <person name="Krizus M."/>
                <person name="Zheng H."/>
                <person name="Brown L."/>
                <person name="Culotti J.G."/>
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        <citation type="journal article" date="1992" name="Cell" volume="71" first="289" last="299">
            <title>UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans.</title>
            <authorList>
                <person name="Leung-Hagesteijn C."/>
                <person name="Spence A.M."/>
                <person name="Stern B.D."/>
                <person name="Zhou Y."/>
                <person name="Su M.-W."/>
                <person name="Hedgecock E.M."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="1384987"/>
            <dbReference type="DOI" id="10.1016/0092-8674(92)90357-I"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND C)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Nature" volume="364" first="327" last="330">
            <title>Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally.</title>
            <authorList>
                <person name="Hamelin M."/>
                <person name="Zhou Y."/>
                <person name="Su M.-W."/>
                <person name="Scott I.M."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="8332188"/>
            <dbReference type="DOI" id="10.1038/364327a0"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Dev. Biol." volume="194" first="72" last="85">
            <title>Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Colavita A."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="9473333"/>
            <dbReference type="DOI" id="10.1006/dbio.1997.8790"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="Development" volume="127" first="585" last="594">
            <title>Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Su M.-W."/>
                <person name="Merz D.C."/>
                <person name="Killeen M.T."/>
                <person name="Zhou Y."/>
                <person name="Zheng H."/>
                <person name="Kramer J.M."/>
                <person name="Hedgecock E.M."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="10631179"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2001" name="Genetics" volume="158" first="1071" last="1080">
            <title>Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivo.</title>
            <authorList>
                <person name="Merz D.C."/>
                <person name="Zheng H."/>
                <person name="Killeen M.T."/>
                <person name="Krizus A."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="11454756"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="40917" last="40925">
            <title>Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.</title>
            <authorList>
                <person name="Tong J."/>
                <person name="Killeen M."/>
                <person name="Steven R."/>
                <person name="Binns K.L."/>
                <person name="Culotti J."/>
                <person name="Pawson T."/>
            </authorList>
            <dbReference type="PubMed" id="11533026"/>
            <dbReference type="DOI" id="10.1074/jbc.M103872200"/>
        </citation>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2002" name="Dev. Biol." volume="251" first="348" last="366">
            <title>UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.</title>
            <authorList>
                <person name="Killeen M."/>
                <person name="Tong J."/>
                <person name="Krizus A."/>
                <person name="Steven R."/>
                <person name="Scott I."/>
                <person name="Pawson T."/>
                <person name="Culotti J."/>
            </authorList>
            <dbReference type="PubMed" id="12435363"/>
            <dbReference type="DOI" id="10.1006/dbio.2002.0825"/>
        </citation>
        <scope>PHOSPHORYLATION AT TYR-510</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF CYS-209; 415-TYR-TYR-416; TYR-445; TYR-467; TYR-510; TYR-566 AND TYR-719</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2005" name="Development" volume="132" first="5161" last="5172">
            <title>SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.</title>
            <authorList>
                <person name="Itoh B."/>
                <person name="Hirose T."/>
                <person name="Takata N."/>
                <person name="Nishiwaki K."/>
                <person name="Koga M."/>
                <person name="Ohshima Y."/>
                <person name="Okada M."/>
            </authorList>
            <dbReference type="PubMed" id="16251208"/>
            <dbReference type="DOI" id="10.1242/dev.02103"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2005" name="Mol. Cell. Biol." volume="25" first="6485" last="6495">
            <title>SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lee J."/>
                <person name="Li W."/>
                <person name="Guan K.L."/>
            </authorList>
            <dbReference type="PubMed" id="16024786"/>
            <dbReference type="DOI" id="10.1128/MCB.25.15.6485-6495.2005"/>
        </citation>
        <scope>INTERACTION WITH SRC-1</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2007" name="Dev. Biol." volume="310" first="44" last="53">
            <title>C. elegans seu-1 encodes novel nuclear proteins that regulate responses to UNC-6/netrin guidance cues.</title>
            <authorList>
                <person name="Zheng H."/>
                <person name="Coudiere L."/>
                <person name="Camia C."/>
                <person name="Colavita A."/>
                <person name="Culotti J.G."/>
                <person name="Merz D.C."/>
            </authorList>
            <dbReference type="PubMed" id="17716643"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.07.014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF CYS-209 AND 311-TRP--PRO-947</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-206</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2009" name="Nat. Neurosci." volume="12" first="150" last="155">
            <title>UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.</title>
            <authorList>
                <person name="MacNeil L.T."/>
                <person name="Hardy W.R."/>
                <person name="Pawson T."/>
                <person name="Wrana J.L."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="19169249"/>
            <dbReference type="DOI" id="10.1038/nn.2256"/>
        </citation>
        <scope>INTERACTION WITH UNC-129</scope>
        <scope>MUTAGENESIS OF 311-TRP--PRO-947</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2013" name="Mol. Cell" volume="50" first="295" last="302">
            <title>C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats.</title>
            <authorList>
                <person name="Buettner F.F."/>
                <person name="Ashikov A."/>
                <person name="Tiemann B."/>
                <person name="Lehle L."/>
                <person name="Bakker H."/>
            </authorList>
            <dbReference type="PubMed" id="23562325"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2013.03.003"/>
        </citation>
        <scope>GLYCOSYLATION AT TRP-305 AND TRP-308</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2014" name="PLoS Genet." volume="10" first="E1004521" last="E1004521">
            <title>EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chan K.K."/>
                <person name="Seetharaman A."/>
                <person name="Bagg R."/>
                <person name="Selman G."/>
                <person name="Zhang Y."/>
                <person name="Kim J."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="25122090"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004521"/>
        </citation>
        <scope>INTERACTION WITH MADD-4</scope>
    </reference>
    <reference key="16">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005446" last="E1005446">
            <title>The Wnt frizzled receptor MOM-5 regulates the UNC-5 Netrin receptor through small GTPase-dependent signaling to determine the polarity of migrating cells.</title>
            <authorList>
                <person name="Levy-Strumpf N."/>
                <person name="Krizus M."/>
                <person name="Zheng H."/>
                <person name="Brown L."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="26292279"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005446"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
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        <citation type="journal article" date="1992" name="Cell" volume="71" first="289" last="299">
            <title>UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans.</title>
            <authorList>
                <person name="Leung-Hagesteijn C."/>
                <person name="Spence A.M."/>
                <person name="Stern B.D."/>
                <person name="Zhou Y."/>
                <person name="Su M.-W."/>
                <person name="Hedgecock E.M."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="1384987"/>
            <dbReference type="DOI" id="10.1016/0092-8674(92)90357-I"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND C)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Nature" volume="364" first="327" last="330">
            <title>Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally.</title>
            <authorList>
                <person name="Hamelin M."/>
                <person name="Zhou Y."/>
                <person name="Su M.-W."/>
                <person name="Scott I.M."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="8332188"/>
            <dbReference type="DOI" id="10.1038/364327a0"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Dev. Biol." volume="194" first="72" last="85">
            <title>Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Colavita A."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="9473333"/>
            <dbReference type="DOI" id="10.1006/dbio.1997.8790"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="Development" volume="127" first="585" last="594">
            <title>Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Su M.-W."/>
                <person name="Merz D.C."/>
                <person name="Killeen M.T."/>
                <person name="Zhou Y."/>
                <person name="Zheng H."/>
                <person name="Kramer J.M."/>
                <person name="Hedgecock E.M."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="10631179"/>
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        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2001" name="Genetics" volume="158" first="1071" last="1080">
            <title>Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivo.</title>
            <authorList>
                <person name="Merz D.C."/>
                <person name="Zheng H."/>
                <person name="Killeen M.T."/>
                <person name="Krizus A."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="11454756"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="40917" last="40925">
            <title>Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.</title>
            <authorList>
                <person name="Tong J."/>
                <person name="Killeen M."/>
                <person name="Steven R."/>
                <person name="Binns K.L."/>
                <person name="Culotti J."/>
                <person name="Pawson T."/>
            </authorList>
            <dbReference type="PubMed" id="11533026"/>
            <dbReference type="DOI" id="10.1074/jbc.M103872200"/>
        </citation>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2002" name="Dev. Biol." volume="251" first="348" last="366">
            <title>UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.</title>
            <authorList>
                <person name="Killeen M."/>
                <person name="Tong J."/>
                <person name="Krizus A."/>
                <person name="Steven R."/>
                <person name="Scott I."/>
                <person name="Pawson T."/>
                <person name="Culotti J."/>
            </authorList>
            <dbReference type="PubMed" id="12435363"/>
            <dbReference type="DOI" id="10.1006/dbio.2002.0825"/>
        </citation>
        <scope>PHOSPHORYLATION AT TYR-510</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF CYS-209; 415-TYR-TYR-416; TYR-445; TYR-467; TYR-510; TYR-566 AND TYR-719</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2005" name="Development" volume="132" first="5161" last="5172">
            <title>SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.</title>
            <authorList>
                <person name="Itoh B."/>
                <person name="Hirose T."/>
                <person name="Takata N."/>
                <person name="Nishiwaki K."/>
                <person name="Koga M."/>
                <person name="Ohshima Y."/>
                <person name="Okada M."/>
            </authorList>
            <dbReference type="PubMed" id="16251208"/>
            <dbReference type="DOI" id="10.1242/dev.02103"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2005" name="Mol. Cell. Biol." volume="25" first="6485" last="6495">
            <title>SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lee J."/>
                <person name="Li W."/>
                <person name="Guan K.L."/>
            </authorList>
            <dbReference type="PubMed" id="16024786"/>
            <dbReference type="DOI" id="10.1128/MCB.25.15.6485-6495.2005"/>
        </citation>
        <scope>INTERACTION WITH SRC-1</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2007" name="Dev. Biol." volume="310" first="44" last="53">
            <title>C. elegans seu-1 encodes novel nuclear proteins that regulate responses to UNC-6/netrin guidance cues.</title>
            <authorList>
                <person name="Zheng H."/>
                <person name="Coudiere L."/>
                <person name="Camia C."/>
                <person name="Colavita A."/>
                <person name="Culotti J.G."/>
                <person name="Merz D.C."/>
            </authorList>
            <dbReference type="PubMed" id="17716643"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.07.014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF CYS-209 AND 311-TRP--PRO-947</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-206</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2009" name="Nat. Neurosci." volume="12" first="150" last="155">
            <title>UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.</title>
            <authorList>
                <person name="MacNeil L.T."/>
                <person name="Hardy W.R."/>
                <person name="Pawson T."/>
                <person name="Wrana J.L."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="19169249"/>
            <dbReference type="DOI" id="10.1038/nn.2256"/>
        </citation>
        <scope>INTERACTION WITH UNC-129</scope>
        <scope>MUTAGENESIS OF 311-TRP--PRO-947</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2013" name="Mol. Cell" volume="50" first="295" last="302">
            <title>C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats.</title>
            <authorList>
                <person name="Buettner F.F."/>
                <person name="Ashikov A."/>
                <person name="Tiemann B."/>
                <person name="Lehle L."/>
                <person name="Bakker H."/>
            </authorList>
            <dbReference type="PubMed" id="23562325"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2013.03.003"/>
        </citation>
        <scope>GLYCOSYLATION AT TRP-305 AND TRP-308</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2014" name="PLoS Genet." volume="10" first="E1004521" last="E1004521">
            <title>EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chan K.K."/>
                <person name="Seetharaman A."/>
                <person name="Bagg R."/>
                <person name="Selman G."/>
                <person name="Zhang Y."/>
                <person name="Kim J."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="25122090"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004521"/>
        </citation>
        <scope>INTERACTION WITH MADD-4</scope>
    </reference>
    <reference key="16">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005446" last="E1005446">
            <title>The Wnt frizzled receptor MOM-5 regulates the UNC-5 Netrin receptor through small GTPase-dependent signaling to determine the polarity of migrating cells.</title>
            <authorList>
                <person name="Levy-Strumpf N."/>
                <person name="Krizus M."/>
                <person name="Zheng H."/>
                <person name="Brown L."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="26292279"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005446"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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        <event type="alternative splicing"/>
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            <id>Q26261-5</id>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference key="1">
        <citation type="journal article" date="1992" name="Cell" volume="71" first="289" last="299">
            <title>UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans.</title>
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            </authorList>
            <dbReference type="PubMed" id="1384987"/>
            <dbReference type="DOI" id="10.1016/0092-8674(92)90357-I"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND C)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Nature" volume="364" first="327" last="330">
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            <authorList>
                <person name="Hamelin M."/>
                <person name="Zhou Y."/>
                <person name="Su M.-W."/>
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                <person name="Culotti J.G."/>
            </authorList>
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        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
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            <title>Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.</title>
            <authorList>
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                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="9473333"/>
            <dbReference type="DOI" id="10.1006/dbio.1997.8790"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
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            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="Development" volume="127" first="585" last="594">
            <title>Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Su M.-W."/>
                <person name="Merz D.C."/>
                <person name="Killeen M.T."/>
                <person name="Zhou Y."/>
                <person name="Zheng H."/>
                <person name="Kramer J.M."/>
                <person name="Hedgecock E.M."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="10631179"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2001" name="Genetics" volume="158" first="1071" last="1080">
            <title>Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivo.</title>
            <authorList>
                <person name="Merz D.C."/>
                <person name="Zheng H."/>
                <person name="Killeen M.T."/>
                <person name="Krizus A."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="11454756"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="40917" last="40925">
            <title>Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.</title>
            <authorList>
                <person name="Tong J."/>
                <person name="Killeen M."/>
                <person name="Steven R."/>
                <person name="Binns K.L."/>
                <person name="Culotti J."/>
                <person name="Pawson T."/>
            </authorList>
            <dbReference type="PubMed" id="11533026"/>
            <dbReference type="DOI" id="10.1074/jbc.M103872200"/>
        </citation>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2002" name="Dev. Biol." volume="251" first="348" last="366">
            <title>UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.</title>
            <authorList>
                <person name="Killeen M."/>
                <person name="Tong J."/>
                <person name="Krizus A."/>
                <person name="Steven R."/>
                <person name="Scott I."/>
                <person name="Pawson T."/>
                <person name="Culotti J."/>
            </authorList>
            <dbReference type="PubMed" id="12435363"/>
            <dbReference type="DOI" id="10.1006/dbio.2002.0825"/>
        </citation>
        <scope>PHOSPHORYLATION AT TYR-510</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF CYS-209; 415-TYR-TYR-416; TYR-445; TYR-467; TYR-510; TYR-566 AND TYR-719</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2005" name="Development" volume="132" first="5161" last="5172">
            <title>SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.</title>
            <authorList>
                <person name="Itoh B."/>
                <person name="Hirose T."/>
                <person name="Takata N."/>
                <person name="Nishiwaki K."/>
                <person name="Koga M."/>
                <person name="Ohshima Y."/>
                <person name="Okada M."/>
            </authorList>
            <dbReference type="PubMed" id="16251208"/>
            <dbReference type="DOI" id="10.1242/dev.02103"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2005" name="Mol. Cell. Biol." volume="25" first="6485" last="6495">
            <title>SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lee J."/>
                <person name="Li W."/>
                <person name="Guan K.L."/>
            </authorList>
            <dbReference type="PubMed" id="16024786"/>
            <dbReference type="DOI" id="10.1128/MCB.25.15.6485-6495.2005"/>
        </citation>
        <scope>INTERACTION WITH SRC-1</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2007" name="Dev. Biol." volume="310" first="44" last="53">
            <title>C. elegans seu-1 encodes novel nuclear proteins that regulate responses to UNC-6/netrin guidance cues.</title>
            <authorList>
                <person name="Zheng H."/>
                <person name="Coudiere L."/>
                <person name="Camia C."/>
                <person name="Colavita A."/>
                <person name="Culotti J.G."/>
                <person name="Merz D.C."/>
            </authorList>
            <dbReference type="PubMed" id="17716643"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.07.014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF CYS-209 AND 311-TRP--PRO-947</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-206</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2009" name="Nat. Neurosci." volume="12" first="150" last="155">
            <title>UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.</title>
            <authorList>
                <person name="MacNeil L.T."/>
                <person name="Hardy W.R."/>
                <person name="Pawson T."/>
                <person name="Wrana J.L."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="19169249"/>
            <dbReference type="DOI" id="10.1038/nn.2256"/>
        </citation>
        <scope>INTERACTION WITH UNC-129</scope>
        <scope>MUTAGENESIS OF 311-TRP--PRO-947</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2013" name="Mol. Cell" volume="50" first="295" last="302">
            <title>C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats.</title>
            <authorList>
                <person name="Buettner F.F."/>
                <person name="Ashikov A."/>
                <person name="Tiemann B."/>
                <person name="Lehle L."/>
                <person name="Bakker H."/>
            </authorList>
            <dbReference type="PubMed" id="23562325"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2013.03.003"/>
        </citation>
        <scope>GLYCOSYLATION AT TRP-305 AND TRP-308</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2014" name="PLoS Genet." volume="10" first="E1004521" last="E1004521">
            <title>EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chan K.K."/>
                <person name="Seetharaman A."/>
                <person name="Bagg R."/>
                <person name="Selman G."/>
                <person name="Zhang Y."/>
                <person name="Kim J."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="25122090"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004521"/>
        </citation>
        <scope>INTERACTION WITH MADD-4</scope>
    </reference>
    <reference key="16">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005446" last="E1005446">
            <title>The Wnt frizzled receptor MOM-5 regulates the UNC-5 Netrin receptor through small GTPase-dependent signaling to determine the polarity of migrating cells.</title>
            <authorList>
                <person name="Levy-Strumpf N."/>
                <person name="Krizus M."/>
                <person name="Zheng H."/>
                <person name="Brown L."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="26292279"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005446"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q26261-2</id>
            <name evidence="3">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q26261-1</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_061199"/>
        </isoform>
        <isoform>
            <id>Q26261-5</id>
            <name evidence="5">e</name>
            <sequence type="described" ref="VSP_061197"/>
        </isoform>
        <isoform>
            <id>Q26261-6</id>
            <name evidence="6">f</name>
            <sequence type="described" ref="VSP_061196"/>
        </isoform>
        <isoform>
            <id>Q26261-4</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_061198"/>
        </isoform>
        <isoform>
            <id>Q26261-3</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_061201 VSP_061200 VSP_061199"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001368390.1">
        <property type="nucleotide sequence ID" value="NM_001380233.1"/>
    </dbReference>
    <dbReference type="WormBase" id="B0273.4f">
        <property type="protein sequence ID" value="CE49300"/>
        <property type="gene ID" value="WBGene00006745"/>
        <property type="gene designation" value="unc-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="B0273.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="B0273.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="B0273.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="B0273.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="B0273.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="B0273.4f"/>
        </source>
    </evidence>
    <sequence length="657" mass="72483" checksum="E2140E8B41511CC3" modified="2021-09-29" version="3" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QW4-3</accession>
    <name>CDF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Cation diffusion facilitator family protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cdf-1</name>
        <name type="ORF">C15B12.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2002" name="Dev. Cell" volume="2" first="567" last="578">
            <title>Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling.</title>
            <authorList>
                <person name="Bruinsma J.J."/>
                <person name="Jirakulaporn T."/>
                <person name="Muslin A.J."/>
                <person name="Kornfeld K."/>
            </authorList>
            <dbReference type="PubMed" id="12015965"/>
            <dbReference type="DOI" id="10.1016/S1534-5807(02)00151-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="27807" last="27815">
            <title>Cation diffusion facilitator proteins modulate Raf-1 activity.</title>
            <authorList>
                <person name="Jirakulaporn T."/>
                <person name="Muslin A.J."/>
            </authorList>
            <dbReference type="PubMed" id="15096503"/>
            <dbReference type="DOI" id="10.1074/jbc.M401210200"/>
        </citation>
        <scope>INTERACTION WITH LIN-45</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003522" last="E1003522">
            <title>ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis.</title>
            <authorList>
                <person name="Roh H.C."/>
                <person name="Collier S."/>
                <person name="Deshmukh K."/>
                <person name="Guthrie J."/>
                <person name="Robertson J.D."/>
                <person name="Kornfeld K."/>
            </authorList>
            <dbReference type="PubMed" id="23717214"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003522"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF 224-GLU--GLU-586</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95QW4-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95QW4-3</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_062616"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C15B12.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C15B12.7b"/>
        </source>
    </evidence>
    <sequence length="544" mass="59182" checksum="8EF293167892D94C" modified="2026-01-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N4U0</accession>
    <name>Q9N4U0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cyh-1</name>
        <name evidence="8" type="ORF">CELE_Y49F6B.1</name>
        <name evidence="10" type="ORF">Y49F6B.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD64712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_494564.2">
        <property type="nucleotide sequence ID" value="NM_062163.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N4U0"/>
    <dbReference type="SMR" id="Q9N4U0"/>
    <dbReference type="STRING" id="6239.Y49F6B.1.1"/>
    <dbReference type="PaxDb" id="6239-Y49F6B.1"/>
    <dbReference type="PeptideAtlas" id="Q9N4U0"/>
    <dbReference type="GeneID" id="190078"/>
    <dbReference type="UCSC" id="Y49F6B.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021714"/>
    <dbReference type="CTD" id="190078"/>
    <dbReference type="WormBase" id="Y49F6B.1a">
        <property type="protein sequence ID" value="CE36037"/>
        <property type="gene ID" value="WBGene00021714"/>
        <property type="gene designation" value="cyh-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022620_2_0_1"/>
    <dbReference type="OMA" id="EPQIMLK"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="PhylomeDB" id="Q9N4U0"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021714">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000029">
        <property type="entry name" value="Cyclin h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000393">
        <property type="entry name" value="CYclin H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="159"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD64712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y49F6B.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N4U0"/>
        </source>
    </evidence>
    <sequence length="332" mass="39037" checksum="FA60645DE57D07C3" modified="2004-03-01" version="2">MYATSTQKREWTYTPEKLAAMRLEINIKFRQKYESVMQPDELELFVTPEEELRMQRSIEDAALKFADKFRPHIWPSVKWTALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEFYITIEDFVKNMNVGEPRQNAERILKLEPELMKILDYNLTVHCPYRPYEGHLMDMKTRMLLLNFDLESIRRDSMRFFQNALQTDVLLLYPPSQIALAAINFGLHAQGKSDEILREFLRKLIGIEEDSWAHRDARPEDLEKLEKTVTRVNQIMREVDRNFVAVTEQERENHKSQLARIQALIPALDERRKEQWLAGGGVGLMPGELAEQPVDSDDEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="160" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N4V2</accession>
    <name>Q9N4V2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotidyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y47D9A.1</name>
        <name evidence="4 6" type="ORF">Y47D9A.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD67160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491350.1">
        <property type="nucleotide sequence ID" value="NM_058949.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N4V2"/>
    <dbReference type="SMR" id="Q9N4V2"/>
    <dbReference type="PeptideAtlas" id="Q9N4V2"/>
    <dbReference type="GeneID" id="172033"/>
    <dbReference type="UCSC" id="Y47D9A.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021628"/>
    <dbReference type="CTD" id="172033"/>
    <dbReference type="WormBase" id="Y47D9A.1b">
        <property type="protein sequence ID" value="CE24353"/>
        <property type="gene ID" value="WBGene00021628"/>
    </dbReference>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021628">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N4V2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="3">
        <location>
            <begin position="256"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD67160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y47D9A.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N4V2"/>
        </source>
    </evidence>
    <sequence length="394" mass="43326" checksum="EBBEFF2A6D637698" modified="2000-10-01" version="1">MFPPPRKCTRFRPLSLQLPKPLFPIAGVPLIEHHIDQLCQLSGLSEILLLGFFPSDVFTDFISRCQQTYRVSIKYLEEPNPLGTAGGLVSFKKQILAGDPDAVFVINADVCGDLPIEDMGAKLDSLSGSSMLMLTTEATRQQSINFGSVVTDSEGRVIHYVDKPTTFVSTNISCGVYLIKAEVIRQLDLPLNGDGIWLETDVLPQLASSGNLYALHTTRWWSQTKTAAAVLYANRHYLRLYKRRYAARLCKNGAQIIGDVFIDPSAKVHPTAKIGPNVSIGPKSVIGKGVRIKESIILPEAVIEENACVLQSVIGWRSVVGMWARIEGIPLEPNPNLPFAKMDNKPLFLPDGRLTPSLTILGSDVSVAPETIILNCVVLPYKELTCSYKNQIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N4W8</accession>
    <name>Q9N4W8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srt-42</name>
        <name evidence="2" type="ORF">CELE_Y46H3A.1</name>
        <name evidence="4" type="ORF">Y46H3A.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD70648.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024244.2">
        <property type="nucleotide sequence ID" value="NM_001029073.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N4W8"/>
    <dbReference type="DIP" id="DIP-26549N"/>
    <dbReference type="GeneID" id="189961"/>
    <dbReference type="KEGG" id="cel:CELE_Y46H3A.1"/>
    <dbReference type="UCSC" id="Y46H3A.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021599"/>
    <dbReference type="CTD" id="189961"/>
    <dbReference type="WormBase" id="Y46H3A.1a">
        <property type="protein sequence ID" value="CE50896"/>
        <property type="gene ID" value="WBGene00021599"/>
        <property type="gene designation" value="srt-42"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053041_3_0_1"/>
    <dbReference type="OrthoDB" id="5873245at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021599">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N4W8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF90">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD70648.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y46H3A.1a"/>
        </source>
    </evidence>
    <sequence length="87" mass="9847" checksum="5921C2926249C9DB" modified="2015-11-11" version="3">MANFIAAMVYVYMQFFPVADFVIVIGHMSWQLGHGCPAIIYLFMNTTIRSGVSKIFRFKKPINTRTTTTVSVVGHGHQHHHHSSSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N516</accession>
    <name>Q9N516_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M28 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_Y39A3B.1</name>
        <name evidence="5 7" type="ORF">Y39A3B.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_497490.2">
        <property type="nucleotide sequence ID" value="NM_065089.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N516"/>
    <dbReference type="SMR" id="Q9N516"/>
    <dbReference type="STRING" id="6239.Y39A3B.1.1"/>
    <dbReference type="PaxDb" id="6239-Y39A3B.1"/>
    <dbReference type="GeneID" id="189721"/>
    <dbReference type="UCSC" id="Y39A3B.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021436"/>
    <dbReference type="CTD" id="189721"/>
    <dbReference type="WormBase" id="Y39A3B.1a">
        <property type="protein sequence ID" value="CE35079"/>
        <property type="gene ID" value="WBGene00021436"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_702714_0_0_1"/>
    <dbReference type="InParanoid" id="Q9N516"/>
    <dbReference type="OMA" id="GFPAVML"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="PhylomeDB" id="Q9N516"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021436">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05640">
        <property type="entry name" value="M28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004330357" evidence="3">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="92"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD73011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y39A3B.1a"/>
        </source>
    </evidence>
    <sequence length="371" mass="41626" checksum="906056BE580E25FA" modified="2003-10-01" version="2">MKGLFKLLSIILGICQLALSLSTIADMDRMKHDLSKFLSISRFNETEKSVARAAIKRALEAVGLNSMTHTFIHEESNEVGANVIAVQKGPYFGTGNDKMMILSANYDTLEGNQGVDDNGSGVAAVLEAARVLSTLDNLYSRQNTIVYVFFDMKHKALAGSHAFVEDVLLPLMERTNTKVVGTVIADGLLHFDPFPASQAMPNEFESFFPEAAQKLHEHSHMGDFIQVSSRSDIDDDLVQKYTRAYDRSCEMLSSDWSFHPWSLNLQMNLANITSLDRLHPFLYSDHSSFFFHSKQKSVQIPTIYLTDTLNLRGVRQYCVQCDGLYMMTEQNMKFLALMTDSLIRLLIDMSGSSASAVVDDLYSFMFNIDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="175" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N517</accession>
    <name>Q9N517_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ligand-Gated ion Channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">lgc-42</name>
        <name evidence="14" type="ORF">CELE_Y39A3B.2</name>
        <name evidence="16" type="ORF">Y39A3B.2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_497489.3">
        <property type="nucleotide sequence ID" value="NM_065088.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N517"/>
    <dbReference type="SMR" id="Q9N517"/>
    <dbReference type="DIP" id="DIP-26084N"/>
    <dbReference type="IntAct" id="Q9N517">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="6239.Y39A3B.2.1"/>
    <dbReference type="PaxDb" id="6239-Y39A3B.2"/>
    <dbReference type="GeneID" id="189722"/>
    <dbReference type="UCSC" id="Y39A3B.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021437"/>
    <dbReference type="CTD" id="189722"/>
    <dbReference type="WormBase" id="Y39A3B.2a">
        <property type="protein sequence ID" value="CE46491"/>
        <property type="gene ID" value="WBGene00021437"/>
        <property type="gene designation" value="lgc-42"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010920_1_4_1"/>
    <dbReference type="InParanoid" id="Q9N517"/>
    <dbReference type="OMA" id="IFHRNRK"/>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="PhylomeDB" id="Q9N517"/>
    <dbReference type="Reactome" id="R-CEL-112314">
        <property type="pathway name" value="Neurotransmitter receptors and postsynaptic signal transmission"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021437">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000051">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022250454" evidence="11">
        <location>
            <begin position="19"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="34"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="239"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD73017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="Y39A3B.2a"/>
        </source>
    </evidence>
    <sequence length="412" mass="47919" checksum="0E636EA8D9794F79" modified="2012-01-25" version="3">MTSNRWLLFFLLLRITLANRDVFRLLQDKPMPRNGNPKAPLQVHFGFYVESLGNFRATEMTYDMDMYLYMSWQDDSMRHNETEHVLVNDKDILDKIWLPDLYFANARTAYFHKVTVHNFNMFISPQGTISYGTRVTLNLACNLDLKDYPLDYQTCYIKVISYAHVKNEMNVSWFPNDPIRFNPEIDLPEFHIRALDKDYCNGVFLYTLTHNSSRVGEFSCLLGMLKLKRAIGFHLVQSYIPTGLIVAISWVSFWIDRRAVPARVSLSFTTLLTLSTQGNGIRYALPAVSYAKAIDYFYGVCMLFIFGVLLEFAAVNSYMRRANKYNHMAEKIQSAYGGKPIIADYDSDYEEGPTKYYGNLNKNSAHLMYKALKFSRKALSIDKAARFAFPCVFAIFNVFYWLYYLREPPLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q9NEQ6</accession>
    <name>Q9NEQ6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">fbxa-106</name>
        <name evidence="2" type="ORF">CELE_Y59A8B.11</name>
        <name evidence="4" type="ORF">Y59A8B.11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB60959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_507530.1">
        <property type="nucleotide sequence ID" value="NM_075129.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9NEQ6"/>
    <dbReference type="SMR" id="Q9NEQ6"/>
    <dbReference type="GeneID" id="190394"/>
    <dbReference type="UCSC" id="Y59A8B.11">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013348"/>
    <dbReference type="CTD" id="190394"/>
    <dbReference type="WormBase" id="Y59A8B.11a">
        <property type="protein sequence ID" value="CE24504"/>
        <property type="gene ID" value="WBGene00013348"/>
        <property type="gene designation" value="fbxa-106"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030831_3_0_1"/>
    <dbReference type="OrthoDB" id="7600185at2759"/>
    <dbReference type="PhylomeDB" id="Q9NEQ6"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013348">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9NEQ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd22150">
        <property type="entry name" value="F-box_CeFBXA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002900">
        <property type="entry name" value="DUF38/FTH_CAE_spp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040161">
        <property type="entry name" value="FB224"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23015:SF4">
        <property type="entry name" value="DUF38 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23015">
        <property type="entry name" value="UNCHARACTERIZED C.ELEGANS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01827">
        <property type="entry name" value="FTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB60959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y59A8B.11a"/>
        </source>
    </evidence>
    <sequence length="297" mass="34813" checksum="18ED552CA4510FDC" modified="2000-10-01" version="1">MSNLPLDVIHKIVEKVEPIERLSVRKVCRNFRAIVDNKDPGIKRVVLNIHHSQFQMWLLDAKSTVIHYDFSHSHCTVNYNDRNERFKGVNGLKMAETDLSVVMKNSKLQLEVLEFQGYDRIQKKETFMNWFKEMSDSKNLYKVKRIDFSINLPTFAATIFPLLQPGFLEEICIYCSGNPDYVDQLFEMEQWKRAKSIFIDSYGEKHFPIENLFHLTHFFIDTAYLSVADAVKIRDILLKSTVFESGIITSRNIFSVGVVRVFNPNFIARRPFRVDYDNGSHFSLLYDHISIKIEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>Q9NF23</accession>
    <name>Q9NF23_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y105E8A.1</name>
        <name evidence="2 4" type="ORF">Y105E8A.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB60842.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_740929.2">
        <property type="nucleotide sequence ID" value="NM_170933.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9NF23"/>
    <dbReference type="SMR" id="Q9NF23"/>
    <dbReference type="DIP" id="DIP-25810N"/>
    <dbReference type="IntAct" id="Q9NF23">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q9NF23"/>
    <dbReference type="GeneID" id="260216"/>
    <dbReference type="UCSC" id="Y105E8A.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013666"/>
    <dbReference type="CTD" id="260216"/>
    <dbReference type="WormBase" id="Y105E8A.1a">
        <property type="protein sequence ID" value="CE36221"/>
        <property type="gene ID" value="WBGene00013666"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084862_3_0_1"/>
    <dbReference type="OMA" id="MYKNIPK"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="PhylomeDB" id="Q9NF23"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013666">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9NF23">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="CDD" id="cd03030">
        <property type="entry name" value="GRX_SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF15">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB60842.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y105E8A.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q9NF23"/>
        </source>
    </evidence>
    <sequence length="132" mass="14756" checksum="1A13DDDB36FDB54F" modified="2004-07-05" version="2">MAPLKVYVASATANPETKYRVQRTLMILDGLGIPFDSIDITKPEHAEQRRFMRENASKKGPNGAVLPPQFFYEDEYLGDYEDFDTSVEADTITEFLRLLPDAIGNRIRVNDANKCVAALFSKTQGAGVKCNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2025-10-08" version="176" xmlns="https://uniprot.org/uniprot">
    <accession>Q9U9J8</accession>
    <accession>Q95ZL8</accession>
    <name>Q9U9J8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Spectrin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">unc-70</name>
        <name evidence="16" type="synonym">bgs-1</name>
        <name evidence="17" type="ORF">CELE_K11C4.3</name>
        <name evidence="19" type="ORF">K11C4.3</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2000" name="J. Cell. Biochem." volume="149" first="915" last="930">
            <title>Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function.</title>
            <authorList>
                <person name="Moorthy S."/>
                <person name="Chen L."/>
                <person name="Bennett V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probably plays an important role in neuronal membrane skeleton.</text>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the spectrin family.</text>
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</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase</fullName>
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        <name evidence="4" type="ORF">CELE_M04G7.2</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001307408.1"/>
    </dbReference>
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    <dbReference type="SMR" id="U4PBF5"/>
    <dbReference type="GeneID" id="187449"/>
    <dbReference type="KEGG" id="cel:CELE_M04G7.2"/>
    <dbReference type="AGR" id="WB:WBGene00019773"/>
    <dbReference type="CTD" id="187449"/>
    <dbReference type="WormBase" id="M04G7.2b">
        <property type="protein sequence ID" value="CE48925"/>
        <property type="gene ID" value="WBGene00019773"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498976_0_0_1"/>
    <dbReference type="OrthoDB" id="8609993at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019773">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBF5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
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        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
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    </dbReference>
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        <property type="entry name" value="Tyr_Pase_AS"/>
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        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
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        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="264"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="438"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDH93050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="M04G7.2b"/>
        </source>
    </evidence>
    <sequence length="548" mass="62385" checksum="8CD2BA50E824B53D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBG0</accession>
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        <submittedName>
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        <name evidence="1" type="ORF">CELE_Y53F4B.11</name>
        <name evidence="1 3" type="ORF">Y53F4B.11</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293549.1">
        <property type="nucleotide sequence ID" value="NM_001306620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBG0"/>
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    <dbReference type="GeneID" id="190213"/>
    <dbReference type="KEGG" id="cel:CELE_Y53F4B.11"/>
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    <dbReference type="CTD" id="190213"/>
    <dbReference type="WormBase" id="Y53F4B.11b">
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        <property type="gene ID" value="WBGene00013158"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1066433_0_0_1"/>
    <dbReference type="OrthoDB" id="5861610at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013158">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBG0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y53F4B.11b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBG0"/>
        </source>
    </evidence>
    <sequence length="116" mass="14128" checksum="00D0A27B6EE41AB0" modified="2013-12-11" version="1">MLWALPREDRSLEEDRFEILTELLDKSCQGLEIWEEHCERKIPLGHRCVLEGELIHLITSKFDLIDKICGEFDKLKNKRSEVNDERDMLRYEIRHCDMIFTEIHEKFLKSYLEMDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBG3</accession>
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        <submittedName>
            <fullName evidence="2">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CELE_M01H9.4</name>
        <name evidence="2 4" type="ORF">M01H9.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294428.1">
        <property type="nucleotide sequence ID" value="NM_001307499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBG3"/>
    <dbReference type="GeneID" id="187391"/>
    <dbReference type="AGR" id="WB:WBGene00019720"/>
    <dbReference type="CTD" id="187391"/>
    <dbReference type="WormBase" id="M01H9.4e">
        <property type="protein sequence ID" value="CE48526"/>
        <property type="gene ID" value="WBGene00019720"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122538_0_0_1"/>
    <dbReference type="OrthoDB" id="5866192at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019720">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBG3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="M01H9.4e"/>
        </source>
    </evidence>
    <sequence length="191" mass="21598" checksum="0E6CFA64AB0A1612" modified="2013-12-11" version="1">MSETVSLKRPRSESDVTEEPDEKYSIHAGNHQQLMMNPAVMAGMPNARGLQPNVGFPLMQYCQMIQQMQHHHQQMEYPMPMIRKDNKDEANSASTTPSSSRRQTLSAGAAGPRPIRVPPQSIFNPMQFGMMPLSQQQIIEEPSTSPTTMPRQQSDPHTYHMPSFQRADEEIYTKFVDSVRKLAAKLAAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBG4</accession>
    <name>U4PBG4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y53F4B.62</name>
        <name evidence="1 3" type="ORF">Y53F4B.62</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293554.1">
        <property type="nucleotide sequence ID" value="NM_001306625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBG4"/>
    <dbReference type="GeneID" id="24105148"/>
    <dbReference type="AGR" id="WB:WBGene00219491"/>
    <dbReference type="CTD" id="24105148"/>
    <dbReference type="WormBase" id="Y53F4B.62b">
        <property type="protein sequence ID" value="CE49058"/>
        <property type="gene ID" value="WBGene00219491"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2640340_0_0_1"/>
    <dbReference type="OrthoDB" id="5842403at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00219491">
        <property type="expression patterns" value="Expressed in embryo and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBG4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y53F4B.62b"/>
        </source>
    </evidence>
    <sequence length="77" mass="9002" checksum="D3B4BF91C87218CD" modified="2013-12-11" version="1">MLSKPETPYKPFPLFKLPMVAANEVMLCMPIVDIPIINLMRDSQMELTIKRNDGRKAVLSTFFNNFFQKFDFLMNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBG7</accession>
    <name>U4PBG7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="5">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">spl-3</name>
        <name evidence="9" type="ORF">CELE_Y104H12D.3</name>
        <name evidence="11" type="ORF">Y104H12D.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="5"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368265.1">
        <property type="nucleotide sequence ID" value="NM_001380038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBG7"/>
    <dbReference type="SMR" id="U4PBG7"/>
    <dbReference type="PeptideAtlas" id="U4PBG7"/>
    <dbReference type="GeneID" id="190868"/>
    <dbReference type="AGR" id="WB:WBGene00022427"/>
    <dbReference type="CTD" id="190868"/>
    <dbReference type="WormBase" id="Y104H12D.3b">
        <property type="protein sequence ID" value="CE48605"/>
        <property type="gene ID" value="WBGene00022427"/>
        <property type="gene designation" value="spl-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_1_1_1"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022427">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBG7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000305">
        <property type="entry name" value="Sphingosine Phosphate Lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDH93203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y104H12D.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBG7"/>
        </source>
    </evidence>
    <sequence length="339" mass="37571" checksum="15CAA8EB2EC95368" modified="2013-12-11" version="1">MKRAIGPRTCMIIASAPNHITGTVDPIEKLAKLAQRYHIPLHVDCTLGGFVLPFMEYADYSVPAFDFRLPGVTSISADLHRYGQCPGRLSVLMYREPAFLRHQFFTNSEWPGGCYATPTMSGGRDGGAVATAWAMMLRKGRDGYINAAQRIIEATRQLAYRLQGLDGVSLRGSADLCVVAFTTSEVNVYNLVDVMVQKGWHVDPLLSPAAARVPISLSMCEEGVLDHFLEDLEMAICNLKSMEPAEKLGTTASFYQMLQKVNDKTLVDELSLIRLAAHYSIPPPAERRSLRTLSVEGRKLSMLGATGDMGKKLEELRRGFQKEKEAKQEALKNENSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBG9</accession>
    <name>U4PBG9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">txt-4</name>
        <name evidence="2" type="ORF">CELE_K03H6.2</name>
        <name evidence="4" type="ORF">K03H6.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368234.1">
        <property type="nucleotide sequence ID" value="NM_001380046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBG9"/>
    <dbReference type="SMR" id="U4PBG9"/>
    <dbReference type="PeptideAtlas" id="U4PBG9"/>
    <dbReference type="GeneID" id="176959"/>
    <dbReference type="KEGG" id="cel:CELE_K03H6.2"/>
    <dbReference type="AGR" id="WB:WBGene00019368"/>
    <dbReference type="CTD" id="176959"/>
    <dbReference type="WormBase" id="K03H6.2b">
        <property type="protein sequence ID" value="CE48611"/>
        <property type="gene ID" value="WBGene00019368"/>
        <property type="gene designation" value="txt-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032957_0_0_1"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019368">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBG9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00741">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF9">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K03H6.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBG9"/>
        </source>
    </evidence>
    <sequence length="114" mass="13385" checksum="1D644C1CAD115713" modified="2013-12-11" version="1">MKLLTAGQPRTGDYAYSNWHQNTFAYSFRIVHAHDMVPHLPFQYELVDHDKMYHHRTEIWYNNDMSIGSSYHVCQEADGFYCSNQNADLSWNDHTHYYNTDLDGYGDKGCPKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBH1</accession>
    <name>U4PBH1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent RNA helicase PRP5/DDX46/KHDC4 KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">ddx-46</name>
        <name evidence="3" type="ORF">CELE_F53H1.1</name>
        <name evidence="5" type="ORF">F53H1.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001427157.1">
        <property type="nucleotide sequence ID" value="NM_001440215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBH1"/>
    <dbReference type="PeptideAtlas" id="U4PBH1"/>
    <dbReference type="GeneID" id="176943"/>
    <dbReference type="AGR" id="WB:WBGene00018776"/>
    <dbReference type="CTD" id="176943"/>
    <dbReference type="WormBase" id="F53H1.1e">
        <property type="protein sequence ID" value="CE48889"/>
        <property type="gene ID" value="WBGene00018776"/>
        <property type="gene designation" value="ddx-46"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076434_0_0_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018776">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBH1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase PRP5/DDX46/KHDC4 KH" evidence="2">
        <location>
            <begin position="139"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F53H1.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBH1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26114" checksum="E7506E84FDE1F8B1" modified="2013-12-11" version="1">MEAGGDDDDDLEEQLSSMIKTKRRVVHGKPQSEKPSSSSGNAKNDREAGKRADQAKLKAEELSTRLKGASQVVQPVEKTAAQLTAEAVLRGAEVAPAQMSAAMLAKEKANRLNEKLNYLGGEAAPTQQQEEAWEYFEEEWDINDFPQQVRYKICSRESVGHVAELAEVGISVRGVHVPPGKEPKNGERRLHLLLEARSERNLKAAKEEIIRIMKEAFRQLTAQLQRGGTQARYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBH5</accession>
    <name>U4PBH5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">OToPetrin-Like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">otpl-1</name>
        <name evidence="15" type="ORF">B0212.1</name>
        <name evidence="13" type="ORF">CELE_B0212.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380142.1">
        <property type="nucleotide sequence ID" value="NM_001392283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBH5"/>
    <dbReference type="SMR" id="U4PBH5"/>
    <dbReference type="GeneID" id="181841"/>
    <dbReference type="AGR" id="WB:WBGene00015035"/>
    <dbReference type="CTD" id="181841"/>
    <dbReference type="WormBase" id="B0212.1c">
        <property type="protein sequence ID" value="CE48561"/>
        <property type="gene ID" value="WBGene00015035"/>
        <property type="gene designation" value="otpl-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011508_3_1_1"/>
    <dbReference type="OrthoDB" id="6429739at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <dbReference type="Bgee" id="WBGene00015035">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBH5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF33">
        <property type="entry name" value="OTOPETRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDH93213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="B0212.1c"/>
        </source>
    </evidence>
    <sequence length="631" mass="71333" checksum="9895F8ACF6380911" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBI0</accession>
    <name>U4PBI0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">tat-2</name>
        <name evidence="19" type="ORF">CELE_H06H21.10</name>
        <name evidence="21" type="ORF">H06H21.10</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294446.1">
        <property type="nucleotide sequence ID" value="NM_001307517.3"/>
    </dbReference>
    <dbReference type="SMR" id="U4PBI0"/>
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    <dbReference type="AGR" id="WB:WBGene00019166"/>
    <dbReference type="CTD" id="177256"/>
    <dbReference type="WormBase" id="H06H21.10e">
        <property type="protein sequence ID" value="CE48811"/>
        <property type="gene ID" value="WBGene00019166"/>
        <property type="gene designation" value="tat-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <dbReference type="Bgee" id="WBGene00019166">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBI0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000107">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF190">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1021"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1067"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1099"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1144"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="916"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1184"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1282"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1284"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="728"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="729"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="864"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="870"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="890"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="893"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="894"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="894"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDH93218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WormBase" id="H06H21.10e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBI0"/>
        </source>
    </evidence>
    <sequence length="1305" mass="147307" checksum="3CB140B8CDDC55E9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBI3</accession>
    <name>U4PBI3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cdh-8</name>
        <name evidence="3" type="ORF">CELE_F18F11.3</name>
        <name evidence="5" type="ORF">F18F11.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294359.1">
        <property type="nucleotide sequence ID" value="NM_001307430.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBI3"/>
    <dbReference type="SMR" id="U4PBI3"/>
    <dbReference type="GeneID" id="184652"/>
    <dbReference type="KEGG" id="cel:CELE_F18F11.3"/>
    <dbReference type="AGR" id="WB:WBGene00017576"/>
    <dbReference type="CTD" id="184652"/>
    <dbReference type="WormBase" id="F18F11.3i">
        <property type="protein sequence ID" value="CE49001"/>
        <property type="gene ID" value="WBGene00017576"/>
        <property type="gene designation" value="cdh-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243615_0_0_1"/>
    <dbReference type="OrthoDB" id="5799622at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017576">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBI3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F18F11.3i"/>
        </source>
    </evidence>
    <sequence length="173" mass="19374" checksum="23CAB17F11C2E654" modified="2013-12-11" version="1">MKNEKKIAENLSNATGLQTIVDKCRQNANFTLMLVHFMDINGQFVNVDRAVNLLMSSSAESRRELRSVYGLREAFPPVPIPSKVPQYILIAVLLFFVISILSMCIWCRQRNNYERKLRHISAQASTVHTVTLGRGGKQTCNPGYGEIPIISRHHHPPPAPPPPTSADLQSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBI4</accession>
    <name>U4PBI4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y37E11AL.2</name>
        <name evidence="2 4" type="ORF">Y37E11AL.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBI4"/>
    <dbReference type="SMR" id="U4PBI4"/>
    <dbReference type="AGR" id="WB:WBGene00021358"/>
    <dbReference type="WormBase" id="Y37E11AL.2b">
        <property type="protein sequence ID" value="CE48522"/>
        <property type="gene ID" value="WBGene00021358"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1311124_0_0_1"/>
    <dbReference type="OrthoDB" id="5836881at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021358">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBI4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y37E11AL.2b"/>
        </source>
    </evidence>
    <sequence length="131" mass="14896" checksum="C5B5B821B883B8F3" modified="2013-12-11" version="1">MTRSRRACFDVANVLETYQPRARTHGHLFVPDPPTPCVKISEDGNQHDAPKEKTAFSSARDSHYENMYQKAIQMAKEMDQMEKVAASPCLDSSQDVELKPADPEKDKKESEEKAKQAKKKYDEDMAKPFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBI7</accession>
    <name>U4PBI7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methionine aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">map-1</name>
        <name evidence="1" type="ORF">CELE_Y37E11AL.7</name>
        <name evidence="3" type="ORF">Y37E11AL.7</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368273.1">
        <property type="nucleotide sequence ID" value="NM_001380156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBI7"/>
    <dbReference type="SMR" id="U4PBI7"/>
    <dbReference type="PeptideAtlas" id="U4PBI7"/>
    <dbReference type="GeneID" id="177128"/>
    <dbReference type="KEGG" id="cel:CELE_Y37E11AL.7"/>
    <dbReference type="AGR" id="WB:WBGene00003129"/>
    <dbReference type="CTD" id="177128"/>
    <dbReference type="WormBase" id="Y37E11AL.7c">
        <property type="protein sequence ID" value="CE48845"/>
        <property type="gene ID" value="WBGene00003129"/>
        <property type="gene designation" value="map-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_2_1_1"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003129">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBI7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y37E11AL.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBI7"/>
        </source>
    </evidence>
    <sequence length="72" mass="8357" checksum="0D83FD27B257948F" modified="2013-12-11" version="1">MKAGNSFTIEPMINAGTYHDDKWPDDWTAVTRDGRRSAQFEQTLLVTDTGCEILTKRDGNRPWFMDQIEQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBJ1</accession>
    <name>U4PBJ1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">lgc-33</name>
        <name evidence="4" type="ORF">CELE_Y55F3BR.4</name>
        <name evidence="6" type="ORF">Y55F3BR.4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294461.1">
        <property type="nucleotide sequence ID" value="NM_001307532.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBJ1"/>
    <dbReference type="SMR" id="U4PBJ1"/>
    <dbReference type="GeneID" id="176910"/>
    <dbReference type="KEGG" id="cel:CELE_Y55F3BR.4"/>
    <dbReference type="AGR" id="WB:WBGene00021941"/>
    <dbReference type="CTD" id="176910"/>
    <dbReference type="WormBase" id="Y55F3BR.4b">
        <property type="protein sequence ID" value="CE48660"/>
        <property type="gene ID" value="WBGene00021941"/>
        <property type="gene designation" value="lgc-33"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059796_0_0_1"/>
    <dbReference type="OrthoDB" id="5870453at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021941">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBJ1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004653307" evidence="2">
        <location>
            <begin position="31"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="3">
        <location>
            <begin position="43"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDH93233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y55F3BR.4b"/>
        </source>
    </evidence>
    <sequence length="398" mass="45618" checksum="DB398C0B68AAB3CD" modified="2013-12-11" version="1">MVASKKIGMMAFTKLACLLLLFYQFSLVSSISQNELNELSRKFKYYHSAVRPAAPDNFVSDRNGTFFNIPVEIHLLATRIVNRNLYLEVIIVMTWIDERLRLRELQDRFSMPSEYPPWHPSLVFAPPVTSKYTTLAPTSGTVNSYNTIKTTVECQTNAWKYPFESFTCTLSVGPEGDETLTVAQFHDLRSHTQKLLTNVFLGDYPTCSLEFIFKSEWPRALLSSFLPSILIVSSVFFAQWKRRKIQILVSLAAMVGILIMLCSQRPYTSTTLMDLWLCANFIHSVFLVFVDLTLPARRVRYTLMVHVDEEKKQANPVKIMTSEHSGPLRYVNHVIDYLMKKEHKPRTTIVTACPGPTPIQRQITTAMLGNRKRAALFCIFLSYLTFLLIYAIIVIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBJ5</accession>
    <name>U4PBJ5_CAEEL</name>
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        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">eel-1</name>
        <name evidence="16" type="ORF">CELE_Y67D8C.5</name>
        <name evidence="18" type="ORF">Y67D8C.5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294466.1">
        <property type="nucleotide sequence ID" value="NM_001307537.4"/>
    </dbReference>
    <dbReference type="SMR" id="U4PBJ5"/>
    <dbReference type="GeneID" id="177084"/>
    <dbReference type="KEGG" id="cel:CELE_Y67D8C.5"/>
    <dbReference type="AGR" id="WB:WBGene00022069"/>
    <dbReference type="CTD" id="177084"/>
    <dbReference type="WormBase" id="Y67D8C.5b">
        <property type="protein sequence ID" value="CE48624"/>
        <property type="gene ID" value="WBGene00022069"/>
        <property type="gene designation" value="eel-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022069">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBJ5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA_VP13D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000126">
        <property type="entry name" value="Enhancer of EfL-1 mutant phenotype"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
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        <property type="entry name" value="HECT_dom"/>
    </dbReference>
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        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041969">
        <property type="entry name" value="VP13D_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF908"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="14">
        <location>
            <begin position="1436"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="3843"/>
            <end position="4179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="493"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="810"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1120"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2034"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2373"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2799"/>
            <end position="2944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="3003"/>
            <end position="3039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="3594"/>
            <end position="3662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="2179"/>
            <end position="2218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
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            <end position="555"/>
        </location>
    </feature>
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        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="825"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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        </location>
    </feature>
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    </feature>
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            <end position="2526"/>
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        <location>
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            <end position="2547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <end position="2812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2813"/>
            <end position="2829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2837"/>
            <end position="2853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2854"/>
            <end position="2874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2891"/>
            <end position="2901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2902"/>
            <end position="2917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2925"/>
            <end position="2936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="3012"/>
            <end position="3039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="3602"/>
            <end position="3614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="3615"/>
            <end position="3649"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="4146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDH93238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="Y67D8C.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBJ5"/>
        </source>
    </evidence>
    <sequence length="4179" mass="465687" checksum="467CD73DB2CC4FE7" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBK4</accession>
    <name>U4PBK4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fln-1</name>
        <name evidence="6" type="ORF">CELE_Y66H1B.2</name>
        <name evidence="8" type="ORF">Y66H1B.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294369.1">
        <property type="nucleotide sequence ID" value="NM_001307440.3"/>
    </dbReference>
    <dbReference type="SMR" id="U4PBK4"/>
    <dbReference type="PeptideAtlas" id="U4PBK4"/>
    <dbReference type="GeneID" id="176855"/>
    <dbReference type="AGR" id="WB:WBGene00022048"/>
    <dbReference type="CTD" id="176855"/>
    <dbReference type="WormBase" id="Y66H1B.2q">
        <property type="protein sequence ID" value="CE48804"/>
        <property type="gene ID" value="WBGene00022048"/>
        <property type="gene designation" value="fln-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022048">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBK4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21230">
        <property type="entry name" value="CH_FLN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000140">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001719">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001876">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001886">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000096">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="120"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="235"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="409"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="504"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="601"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="789"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1339"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1428"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1520"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1637"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1713"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1827"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1904"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="2029"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1213"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1237"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH93097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y66H1B.2q"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBK4"/>
        </source>
    </evidence>
    <sequence length="2123" mass="230809" checksum="1D49877873933C01" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBK8</accession>
    <name>U4PBK8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cki-2</name>
        <name evidence="8" type="ORF">CELE_T05A6.2</name>
        <name evidence="10" type="ORF">T05A6.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDI family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368240.1">
        <property type="nucleotide sequence ID" value="NM_001381510.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBK8"/>
    <dbReference type="SMR" id="U4PBK8"/>
    <dbReference type="GeneID" id="174261"/>
    <dbReference type="AGR" id="WB:WBGene00000517"/>
    <dbReference type="CTD" id="174261"/>
    <dbReference type="WormBase" id="T05A6.2c">
        <property type="protein sequence ID" value="CE48567"/>
        <property type="gene ID" value="WBGene00000517"/>
        <property type="gene designation" value="cki-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1572030_0_0_1"/>
    <dbReference type="OrthoDB" id="6373236at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000517">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBK8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902806">
        <property type="term" value="P:regulation of cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265:SF45">
        <property type="entry name" value="DACAPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 8" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="7">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDH93103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="T05A6.2c"/>
        </source>
    </evidence>
    <sequence length="175" mass="19442" checksum="FF030F859DFCDB93" modified="2013-12-11" version="1">MAATTAGDGKRKAARCLFGKPDPEEVSRQLNSSLEEMYKKDSRKFNFDFSGGVPIVGSRGDYEFESISASEVPSFYREKIVRPRKIIARRNSTPVSDTVEMPSESPPVVESNETPLLIASTSTEVTVYEKPVTRSSAAKQSIEQQETYNLKQTKLTICQFIFYSTTQSISISCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBK9</accession>
    <name>U4PBK9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CCT-theta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">cct-8</name>
        <name evidence="10" type="ORF">CELE_Y55F3AR.3</name>
        <name evidence="12" type="ORF">Y55F3AR.3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. Required for correct subcellular localization of pgl-1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterooligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294477.1">
        <property type="nucleotide sequence ID" value="NM_001307548.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBK9"/>
    <dbReference type="SMR" id="U4PBK9"/>
    <dbReference type="PeptideAtlas" id="U4PBK9"/>
    <dbReference type="GeneID" id="176928"/>
    <dbReference type="AGR" id="WB:WBGene00021934"/>
    <dbReference type="CTD" id="176928"/>
    <dbReference type="WormBase" id="Y55F3AR.3b">
        <property type="protein sequence ID" value="CE48779"/>
        <property type="gene ID" value="WBGene00021934"/>
        <property type="gene designation" value="cct-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021934">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBK9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDH93254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y55F3AR.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBK9"/>
        </source>
    </evidence>
    <sequence length="427" mass="46376" checksum="6E38D10FBE547BA9" modified="2013-12-11" version="1">MTPQEVAAGYEQAAEKALEILPTLVVKEATDMKNIEEVRQYIRSAITSKQYDNEDIIADLVAKACVTTCPANSFNFNVDNIRICKIIGSGVHTSTVMNGMVFKRGAEGEIREARDARIAVYTCPFDLTQTETKGTVLIENADELRNFSKGEEAEVEEQVKAIADNGVKVVVAAGKFGDMYLHFLNKYKIMAVRLTSKFDLRRLCRTVGAQPQARICAPAVNLLGHCDSVAVQEIGDENVVVFDKKSETGKVATIIIRGSSQSRIDDVERAVDDAVNTYKALTKDGKLLAGAGAVEIELAKEIESFGAKAPGLEQYAIKKFAHALETLPKAIAENAGMPTTETLTKLYAEHVAGKKNAGIDIWKRETMDAVVNNIFDLYAGKRLAIKLATDAASTILKVDQIIMSKQATGGPKPRGPKAQDEDDDGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>V6CJY6</accession>
    <name>V6CJY6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cest-5.1</name>
        <name evidence="5" type="ORF">C01B10.4</name>
        <name evidence="3" type="ORF">CELE_C01B10.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380154.1">
        <property type="nucleotide sequence ID" value="NM_001392320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CJY6"/>
    <dbReference type="ESTHER" id="caeel-c01b10.4">
        <property type="family name" value="Carb_B_Nematoda"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="V6CJY6"/>
    <dbReference type="GeneID" id="177429"/>
    <dbReference type="KEGG" id="cel:CELE_C01B10.4"/>
    <dbReference type="AGR" id="WB:WBGene00015279"/>
    <dbReference type="CTD" id="177429"/>
    <dbReference type="WormBase" id="C01B10.4b">
        <property type="protein sequence ID" value="CE49435"/>
        <property type="gene ID" value="WBGene00015279"/>
        <property type="gene designation" value="cest-5.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458737_0_0_1"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015279">
        <property type="expression patterns" value="Expressed in material anatomical entity and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CJY6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45580:SF6">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45580">
        <property type="entry name" value="PROTEIN CBG05369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="57"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C01B10.4b"/>
        </source>
    </evidence>
    <sequence length="252" mass="29610" checksum="C3172E110C2D511D" modified="2014-02-19" version="1">MLTGCTNLEFDHESIKVPFGKYLEFENPDECDEKYRNDVESGVENRGNHTDKTQGIILPLKLQINNLLENNVTAYLYEYTYPKHGRHTDDLSYIMGVHAFEKDENEVHLEQVYKDMVINFIKLGEPGMGFEKSEQNESTYFDIYWNETTGERPRMRKYFEKEVTDYWLKEMIEFDQKVTETKKKLKQISLKTVPFIEKPLEQNDEAGTLIGVSLIAISIFLIGCIFGRYCCLRRRNLYIRLDGNNYENAGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>V6CJZ0</accession>
    <name>V6CJZ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rap-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">hgap-1</name>
        <name evidence="4" type="ORF">CELE_Y18H1A.3</name>
        <name evidence="6" type="ORF">Y18H1A.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293170.1">
        <property type="nucleotide sequence ID" value="NM_001306241.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CJZ0"/>
    <dbReference type="SMR" id="V6CJZ0"/>
    <dbReference type="PeptideAtlas" id="V6CJZ0"/>
    <dbReference type="GeneID" id="171663"/>
    <dbReference type="AGR" id="WB:WBGene00021209"/>
    <dbReference type="CTD" id="171663"/>
    <dbReference type="WormBase" id="Y18H1A.3c">
        <property type="protein sequence ID" value="CE49321"/>
        <property type="gene ID" value="WBGene00021209"/>
        <property type="gene designation" value="hgap-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006276_0_0_1"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021209">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CJZ0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF11">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="523"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDK13358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y18H1A.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="V6CJZ0"/>
        </source>
    </evidence>
    <sequence length="748" mass="82976" checksum="926F62C884E15C7E" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MAU2</accession>
    <name>A0A131MAU2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F33D11.16</name>
        <name evidence="2 4" type="ORF">F33D11.16</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CZR14434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309521.1">
        <property type="nucleotide sequence ID" value="NM_001322675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MAU2"/>
    <dbReference type="SMR" id="A0A131MAU2"/>
    <dbReference type="GeneID" id="27219615"/>
    <dbReference type="AGR" id="WB:WBGene00269382"/>
    <dbReference type="CTD" id="27219615"/>
    <dbReference type="WormBase" id="F33D11.16b">
        <property type="protein sequence ID" value="CE51477"/>
        <property type="gene ID" value="WBGene00269382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00269382">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MAU2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F33D11.16b"/>
        </source>
    </evidence>
    <sequence length="39" mass="4603" checksum="59D3C2ED3128D113" modified="2016-05-11" version="1">MLDSRDYGSWRNGTTPSPSTNNKSPPVFQNEKKRVHWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MAU8</accession>
    <name>A0A131MAU8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_K02C4.3</name>
        <name evidence="5 7" type="ORF">K02C4.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MAU8"/>
    <dbReference type="AGR" id="WB:WBGene00010502"/>
    <dbReference type="CTD" id="174300"/>
    <dbReference type="WormBase" id="K02C4.3c">
        <property type="protein sequence ID" value="CE51298"/>
        <property type="gene ID" value="WBGene00010502"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010502">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MAU8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02665">
        <property type="entry name" value="Peptidase_C19I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF940">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE K02C4.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="168"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="634"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CZR14486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="K02C4.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MAU8"/>
        </source>
    </evidence>
    <sequence length="1259" mass="142780" checksum="30F3649FF72B66E3" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB63</accession>
    <name>A0A131MB63_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear Hormone Receptor family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nhr-221</name>
        <name evidence="13" type="ORF">CELE_T24A6.8</name>
        <name evidence="15" type="ORF">T24A6.8</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309664.1">
        <property type="nucleotide sequence ID" value="NM_001322529.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB63"/>
    <dbReference type="SMR" id="A0A131MB63"/>
    <dbReference type="GeneID" id="188826"/>
    <dbReference type="KEGG" id="cel:CELE_T24A6.8"/>
    <dbReference type="AGR" id="WB:WBGene00020748"/>
    <dbReference type="CTD" id="188826"/>
    <dbReference type="WormBase" id="T24A6.8b">
        <property type="protein sequence ID" value="CE14138"/>
        <property type="gene ID" value="WBGene00020748"/>
        <property type="gene designation" value="nhr-221"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984314at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020748">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MB63">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000070">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
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        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
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        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
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    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
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            <end position="75"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CZR14589.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="T24A6.8b"/>
        </source>
    </evidence>
    <sequence length="364" mass="42363" checksum="F40BE8EF3E9235E1" modified="2016-05-11" version="1">MVCVRPAHGYHCDVATCKGCKTFFRRMCLLRGEIKCSTSGDCYDLEKRNSPLLRCRPCRFKRCLLVGMNPKALIIDGSNILGEKQVHFNEQQIQGTIDVLSHLEAKTEQFSKCAYNPDWTNIRLKDLILSPSKLSMSDKVGTFPDWPLCPNYEFPDQIVHRDIQSFSPHRKQWRFSNLMTAVEYTKTFSFFHDLSFQDQINLLKHVVIGLANFNTTYYTLKNKFDDLRQPDGTQRPGVNEPHYCAHTVPFGPMKRIKIQFNEFLLLKILFVCNPAVPNLSKHAQFVIEKERHHYSNILLKYCLQNYSYGPTRFVELIEIFGVLHRQQKLMNDLYIYVLSPLLLKLPKEFSVPLIEEIVLLYALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB70</accession>
    <name>A0A131MB70_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class BC (Class B-like)</fullName>
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        <name evidence="2 4" type="primary">srbc-1</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CE51464"/>
        <property type="gene ID" value="WBGene00018058"/>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F35F10.9b"/>
        </source>
    </evidence>
    <sequence length="175" mass="20152" checksum="8A3308EB4A5E30F0" modified="2016-05-11" version="1">MFHNYRHLCPSILILILAISLAMLENLIIYLFCTLNISAIPRDCGVLRCSLDNCYFNYWTTDRSVLFALNFAFSGLLSTRLLLFNKKHNHNAGEEHTKINHIALIDAANVFLCDFLPTFSNYVNDYPFFSFKNIGPYVYIIKLVGSAVESYFIFKVLKRRSARSSVVVITRTFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB76</accession>
    <name>A0A131MB76_CAEEL</name>
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        <submittedName>
            <fullName evidence="14">Synaptogenesis protein syg-2</fullName>
        </submittedName>
    </protein>
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        <name evidence="14 16" type="primary">syg-2</name>
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        <name evidence="14" type="ORF">CELE_C26G2.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="CZR14600.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001322663.4"/>
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        <property type="gene ID" value="WBGene00007750"/>
        <property type="gene designation" value="syg-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10028801at2759"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hibris, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
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        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
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        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FN3_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
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        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
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        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF136">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="8"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007283698" evidence="11">
        <location>
            <begin position="20"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="235"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="331"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="431"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="541"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="742"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="832"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="936"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1191"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CZR14600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="C26G2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MB76"/>
        </source>
    </evidence>
    <sequence length="1230" mass="137183" checksum="477EB68BF27BEC2B" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H9N2</accession>
    <name>A0A168H9N2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear hormone receptor family member nhr-125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nhr-125</name>
        <name evidence="13" type="ORF">CELE_R02D1.1</name>
        <name evidence="15" type="ORF">R02D1.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317832.1">
        <property type="nucleotide sequence ID" value="NM_001330851.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H9N2"/>
    <dbReference type="SMR" id="A0A168H9N2"/>
    <dbReference type="GeneID" id="187520"/>
    <dbReference type="AGR" id="WB:WBGene00003715"/>
    <dbReference type="CTD" id="187520"/>
    <dbReference type="WormBase" id="R02D1.1b">
        <property type="protein sequence ID" value="CE51631"/>
        <property type="gene ID" value="WBGene00003715"/>
        <property type="gene designation" value="nhr-125"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6355676at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003715">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A168H9N2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C.elegans_Orphan_NR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680:SF32">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="149"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SAP35594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="R02D1.1b"/>
        </source>
    </evidence>
    <sequence length="395" mass="46166" checksum="6CC231C362F87A27" modified="2016-07-06" version="1">MDLVSTSTSPFSCRICNQKAHGNHFGVLTCRACASFFRRAAFSKWSQLKCQKGGCSRNFCKRCRLKKCREMGMDTTKFQYNRDSFRATGQFQLPPPRSLASFVGRPELFLFCDTEAPNAKMLIDVRYLLEEAGRIINQGYETPASGKNQLENLTEGFKYIKVDMNNISSSKYASKDAIISMWEYYFFTVTRWLMYFEGFQKLNSHTQITLIQSVWNVWSRLHKYVATVDYHKANPDTLPTNVVIHNTLVDIENVEFDSTWLSDYPVEHVRRYLSVQHCREFDILGTLRKLNPSELEITYLFAQICFEHAGKRNQGDIMKVTEQFLDSLANDLHDYYVNEMNNSRYFLRLTQLLKINQAIQKGIWESRPKMELGRVFNVLKIEFSHPEMFEDSGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H9Z7</accession>
    <name>A0A168H9Z7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NadR/Ttd14 AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">unc-132</name>
        <name evidence="2" type="ORF">CELE_W08A12.1</name>
        <name evidence="4" type="ORF">W08A12.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317835.1">
        <property type="nucleotide sequence ID" value="NM_001330803.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H9Z7"/>
    <dbReference type="GeneID" id="178787"/>
    <dbReference type="AGR" id="WB:WBGene00021078"/>
    <dbReference type="CTD" id="178787"/>
    <dbReference type="WormBase" id="W08A12.1e">
        <property type="protein sequence ID" value="CE51676"/>
        <property type="gene ID" value="WBGene00021078"/>
        <property type="gene designation" value="unc-132"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021078">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A168H9Z7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001321">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.320.10:FF:000003">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053227">
        <property type="entry name" value="TRPL-trafficking_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932:SF1">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SAP35597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="W08A12.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A168H9Z7"/>
        </source>
    </evidence>
    <sequence length="419" mass="48541" checksum="0D4E1185B808A987" modified="2016-07-06" version="1">MSTTVPHDRTETGSPENERKFKVYKIVLTGGPCGGKTTAQVRLATFFENLGWKVFTVPETATILLGGRVKFSELDTEQSYIFQRDLLATMHQIENTFFNQASAIKDRNVLIICDRGCMDPSAYSSPEDWQRMLKDLNYEEFDLRCSRYDQIAHLVTAADGAEKYYTLANNATRSEGVSHAMELDKRTRSVWIGHPYMDIIDNKNTSTFDDKVNKLIQVVCDRTGIRSGDRLAKDSKKRKWLVSAVDWKNFGKFEEFDIEHFYLLSDESNIQHRFRRRTQNNRSTYTLTSREYFKESKDSIETRMNVLSRDYNTYANMRDKSRASIYKKRRCFMYGNMYFNMDIYSDPLPPQANGNHLIFLETYTTVVKGTPLPEGSMPPFLTIEKEITGDSQYSMYSLSKYTKVANKNEFAGADKYKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DQJ7</accession>
    <name>A0A3B1DQJ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mec-2</name>
        <name evidence="7" type="ORF">CELE_F14D12.4</name>
        <name evidence="9" type="ORF">F14D12.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355460.1">
        <property type="nucleotide sequence ID" value="NM_001368504.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1DQJ7"/>
    <dbReference type="SMR" id="A0A3B1DQJ7"/>
    <dbReference type="GeneID" id="180826"/>
    <dbReference type="AGR" id="WB:WBGene00003166"/>
    <dbReference type="CTD" id="180826"/>
    <dbReference type="WormBase" id="F14D12.4q">
        <property type="protein sequence ID" value="CE52735"/>
        <property type="gene ID" value="WBGene00003166"/>
        <property type="gene designation" value="mec-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003166">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1DQJ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03403">
        <property type="entry name" value="SPFH_stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="57"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VAY52587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F14D12.4q"/>
        </source>
    </evidence>
    <sequence length="399" mass="43343" checksum="34C224CC80C7EC20" modified="2018-12-05" version="1">MTVDAPSIRTENIRYFPKKGKTPKKPNIQNEFGVCGWILTILSYLLIFFTLPISACMCIKVVQEYERAVIFRLGRLMPGGAKGPGIFFIVPCIDTYRKVDLRVLSFEVPPQEILSKDSVTVAVDAVVYFRISNATISVTNVEDAARSTKLLAQTTLRNILGTKTLAEMLSDREAISHQMQTTLDEATEPWGVKVERVEVKDVRLPVQLQRAMAAEAEAAREARAKVIVAEGEQKASRALKEAAEVIAESPSALQLRYLQTLNSISAEKNSTIIFPFPIDLLSAFLQRTPPKVEEPPSLPKKIRSCCLYKYPDWVQGMVGSEGGGGHGHSHGGGGGGLGSSQGAFHPSQAGSGPSTTTTSGRPLLRSMREAQFHSAAPPISAPNQSQTSVSQLDPALLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V0INL1</accession>
    <name>A0A4V0INL1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F18E9.8</name>
        <name evidence="2 4" type="ORF">F18E9.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VTW47559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V0INL1"/>
    <dbReference type="AGR" id="WB:WBGene00044780"/>
    <dbReference type="WormBase" id="F18E9.8b">
        <property type="protein sequence ID" value="CE53371"/>
        <property type="gene ID" value="WBGene00044780"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859007at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A4V0INL1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VTW47559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F18E9.8b"/>
        </source>
    </evidence>
    <sequence length="96" mass="11165" checksum="3E394F820391C44C" modified="2019-07-31" version="1">MGITPVVIPAMPLGYSVGFYRYFFNCHQMLTLSLICMTTSASTTVEIFFWRWQNIILPNSRHSDGKQRISCYTGQREKCTTSQTCRKYNLLKKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V0INL2</accession>
    <name>A0A4V0INL2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BAI1-associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CELE_F54G2.1</name>
        <name evidence="11 13" type="ORF">F54G2.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the unc-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VTW47600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V0INL2"/>
    <dbReference type="SMR" id="A0A4V0INL2"/>
    <dbReference type="AGR" id="WB:WBGene00018837"/>
    <dbReference type="WormBase" id="F54G2.1f">
        <property type="protein sequence ID" value="CE53218"/>
        <property type="gene ID" value="WBGene00018837"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7976202at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A4V0INL2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08676">
        <property type="entry name" value="C2A_Munc13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04009">
        <property type="entry name" value="C2B_Munc13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF9">
        <property type="entry name" value="BAI1-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="95"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="9">
        <location>
            <begin position="617"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="10">
        <location>
            <begin position="854"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VTW47600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F54G2.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A4V0INL2"/>
        </source>
    </evidence>
    <sequence length="1151" mass="131908" checksum="1D51E0974485E23A" modified="2019-07-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V0INN2</accession>
    <name>A0A4V0INN2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Suppressor of Constitutive Dauer formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">scd-1</name>
        <name evidence="3" type="ORF">CELE_H20J18.1</name>
        <name evidence="5" type="ORF">H20J18.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VTW47610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360784.1">
        <property type="nucleotide sequence ID" value="NM_001373535.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V0INN2"/>
    <dbReference type="GeneID" id="181408"/>
    <dbReference type="AGR" id="WB:WBGene00004739"/>
    <dbReference type="CTD" id="181408"/>
    <dbReference type="WormBase" id="H20J18.1h">
        <property type="protein sequence ID" value="CE53200"/>
        <property type="gene ID" value="WBGene00004739"/>
        <property type="gene designation" value="scd-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017659at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A4V0INN2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="760"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="826"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VTW47610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="H20J18.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A4V0INN2"/>
        </source>
    </evidence>
    <sequence length="911" mass="97696" checksum="F0C531CDB5030610" modified="2019-07-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V0INP7</accession>
    <name>A0A4V0INP7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">unc-58</name>
        <name evidence="11" type="ORF">CELE_T06H11.1</name>
        <name evidence="13" type="ORF">T06H11.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VTW47620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360794.1">
        <property type="nucleotide sequence ID" value="NM_001373459.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V0INP7"/>
    <dbReference type="GeneID" id="181224"/>
    <dbReference type="AGR" id="WB:WBGene00006792"/>
    <dbReference type="CTD" id="181224"/>
    <dbReference type="WormBase" id="T06H11.1g">
        <property type="protein sequence ID" value="CE53293"/>
        <property type="gene ID" value="WBGene00006792"/>
        <property type="gene designation" value="unc-58"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5916454at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A4V0INP7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF310">
        <property type="entry name" value="UNCOORDINATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="206"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VTW47620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="T06H11.1g"/>
        </source>
    </evidence>
    <sequence length="511" mass="58166" checksum="DBC2B524BD11C931" modified="2019-07-31" version="1">MIFSQAFRNEQFSPAVALFSAAGLIKTTAGIKEEEENEQQNNRKKDHVTARWEGANINSQSALLDADDGATVITDTIKDDQDDKEPKSCPQQTVKYIKILTPHVILVSVLIGYLCLGAWILMLLETRTELLARSKKLVRLTNLMSNFTAESWKMLNNAQHGVSNMDEGEWAATFREWMVRVSETVDDRRPIRRELNRPDDLSNMHNKWTFPTAILYVLTVLTTCGYGEVSVDTDVGKVFSVAFALVGIPLMFITAADIGKFLSETLLQFVSFWNRSVRKVKQWMSRIRHGRRKSLQSTGGPNDTLDILGVDGTEEKLWFPIGAYVSCICIYCSIGSAMFITWERTWSFIHAFHFGFNLIVTVGLGDIVVTDYIFLSLIVAFVIVGLSVVTMCVDLASTHLKAYFTRIHYFGRAKRFLGMSEELKEIVALLGAMRRKKGGKVTWNDVRDFLDNELRDRPFEPHELLMKLRFIDETSSGMSTIRHNSFQSDFFRESEYIRRVAALRPEQPAYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-12-14" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5S9MMK5-2</accession>
    <name>FPEB1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of FLYWCH-type zinc finger-containing protein peb-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pharyngeal enhancer binding protein peb-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">peb-1</name>
        <name evidence="6" type="ORF">T14F9.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2001" name="Dev. Biol." volume="229" first="480" last="493">
            <title>The Caenorhabditis elegans peb-1 gene encodes a novel DNA-binding protein involved in morphogenesis of the pharynx, vulva, and hindgut.</title>
            <authorList>
                <person name="Thatcher J.D."/>
                <person name="Fernandez A.P."/>
                <person name="Beaster-Jones L."/>
                <person name="Haun C."/>
                <person name="Okkema P.G."/>
            </authorList>
            <dbReference type="PubMed" id="11203704"/>
            <dbReference type="DOI" id="10.1006/dbio.2000.9978"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 19-443</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2002" name="J. Mol. Biol." volume="320" first="697" last="704">
            <title>Interference between the PHA-4 and PEB-1 transcription factors in formation of the Caenorhabditis elegans pharynx.</title>
            <authorList>
                <person name="Kalb J.M."/>
                <person name="Beaster-Jones L."/>
                <person name="Fernandez A.P."/>
                <person name="Okkema P.G."/>
                <person name="Goszczynski B."/>
                <person name="McGhee J.D."/>
            </authorList>
            <dbReference type="PubMed" id="12095247"/>
            <dbReference type="DOI" id="10.1016/s0022-2836(02)00555-7"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2004" name="Dev. Biol." volume="276" first="352" last="366">
            <title>C. elegans peb-1 mutants exhibit pleiotropic defects in molting, feeding, and morphology.</title>
            <authorList>
                <person name="Fernandez A.P."/>
                <person name="Gibbons J."/>
                <person name="Okkema P.G."/>
            </authorList>
            <dbReference type="PubMed" id="15581870"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2004.08.040"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2004" name="J. Mol. Biol." volume="339" first="695" last="706">
            <title>DNA binding and in vivo function of C.elegans PEB-1 require a conserved FLYWCH motif.</title>
            <authorList>
                <person name="Beaster-Jones L."/>
                <person name="Okkema P.G."/>
            </authorList>
            <dbReference type="PubMed" id="15165844"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2004.04.030"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF 100-TRP--CYS-102; CYS-114 AND 133-HIS--HIS-135</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A5S9MMK5-1</id>
            <name evidence="6">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A5S9MMK5-3</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061716"/>
        </isoform>
        <isoform>
            <id>A0A5S9MMK5-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_061717"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024910.1">
        <property type="nucleotide sequence ID" value="NM_001029739.6"/>
    </dbReference>
    <dbReference type="WormBase" id="T14F9.4a">
        <property type="protein sequence ID" value="CE07500"/>
        <property type="gene ID" value="WBGene00003968"/>
        <property type="gene designation" value="peb-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAD42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T14F9.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T14F9.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T14F9.4c"/>
        </source>
    </evidence>
    <sequence length="427" mass="47210" checksum="17CA4E4FF7D28724" modified="2020-04-22" version="1">MLGLEKPGSSDISSSSTDTSAISPISVSSMPLSPDKEKKKISFVRYNPDIPQIVTSFKGYQKLMYQGYRYNIYQIAPERNFKSWRCVCAKKMHDGQWCKCRAETTMDNKNACTKGSHNHPPRHHVAEIEFIKSQLYSAALENPDHDAGDLVNQASMYLSDGVMFDNKESIKKSLVVARNKDGKPKKPRSKRMMKFEVDDDDENEYKMPKLETDISCFLPFINNMVKVEPPFSHTPTIQIPQPIPTPIQHQQQEQSNLLQPATLNGMNNPWMGMEDHLAMIWAANAMLNPGLDVLSTIAALSKHQQHVQGPSPQQAATAPTTASLSSNLSVSSFTPQMPKEASIAIPAPLQVLNLKDLKPLPPLANIQTSPVIQAANLLLPVAALKKDSSTQTTEEIKVSQCLTSGCGCRVIRICCCDEGVCRRTAAC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-12-14" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5S9MMK5-3</accession>
    <name>FPEB1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of FLYWCH-type zinc finger-containing protein peb-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pharyngeal enhancer binding protein peb-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">peb-1</name>
        <name evidence="6" type="ORF">T14F9.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2001" name="Dev. Biol." volume="229" first="480" last="493">
            <title>The Caenorhabditis elegans peb-1 gene encodes a novel DNA-binding protein involved in morphogenesis of the pharynx, vulva, and hindgut.</title>
            <authorList>
                <person name="Thatcher J.D."/>
                <person name="Fernandez A.P."/>
                <person name="Beaster-Jones L."/>
                <person name="Haun C."/>
                <person name="Okkema P.G."/>
            </authorList>
            <dbReference type="PubMed" id="11203704"/>
            <dbReference type="DOI" id="10.1006/dbio.2000.9978"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 19-443</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2002" name="J. Mol. Biol." volume="320" first="697" last="704">
            <title>Interference between the PHA-4 and PEB-1 transcription factors in formation of the Caenorhabditis elegans pharynx.</title>
            <authorList>
                <person name="Kalb J.M."/>
                <person name="Beaster-Jones L."/>
                <person name="Fernandez A.P."/>
                <person name="Okkema P.G."/>
                <person name="Goszczynski B."/>
                <person name="McGhee J.D."/>
            </authorList>
            <dbReference type="PubMed" id="12095247"/>
            <dbReference type="DOI" id="10.1016/s0022-2836(02)00555-7"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2004" name="Dev. Biol." volume="276" first="352" last="366">
            <title>C. elegans peb-1 mutants exhibit pleiotropic defects in molting, feeding, and morphology.</title>
            <authorList>
                <person name="Fernandez A.P."/>
                <person name="Gibbons J."/>
                <person name="Okkema P.G."/>
            </authorList>
            <dbReference type="PubMed" id="15581870"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2004.08.040"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2004" name="J. Mol. Biol." volume="339" first="695" last="706">
            <title>DNA binding and in vivo function of C.elegans PEB-1 require a conserved FLYWCH motif.</title>
            <authorList>
                <person name="Beaster-Jones L."/>
                <person name="Okkema P.G."/>
            </authorList>
            <dbReference type="PubMed" id="15165844"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2004.04.030"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF 100-TRP--CYS-102; CYS-114 AND 133-HIS--HIS-135</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A5S9MMK5-3</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061716"/>
        </isoform>
        <isoform>
            <id>A0A5S9MMK5-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_061717"/>
        </isoform>
        <isoform>
            <id>A0A5S9MMK5-1</id>
            <name evidence="6">c</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001364745.1">
        <property type="nucleotide sequence ID" value="NM_001377613.2"/>
    </dbReference>
    <dbReference type="WormBase" id="T14F9.4b">
        <property type="protein sequence ID" value="CE48479"/>
        <property type="gene ID" value="WBGene00003968"/>
        <property type="gene designation" value="peb-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAD42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T14F9.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T14F9.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T14F9.4c"/>
        </source>
    </evidence>
    <sequence length="272" mass="29770" checksum="C3F692F3447708A1" modified="2020-04-22" version="1">MYLSDGVMFDNKESIKKSLVVARNKDGKPKKPRSKRMMKFEVDDDDENEYKMPKLETDISCFLPFINNMVKVEPPFSHTPTIQIPQPIPTPIQHQQQEQSNLLQPATLNGMNNPWMGMEDHLAMIWAANAMLNPGLDVLSTIAALSKHQQHVQGPSPQQAATAPTTASLSSNLSVSSFTPQMPKEASIAIPAPLQVLNLKDLKPLPPLANIQTSPVIQAANLLLPVAALKKDSSTQTTEEIKVSQCLTSGCGCRVIRICCCDEGVCRRTAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B3KYB9</accession>
    <name>B3KYB9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y6B3B.9</name>
        <name evidence="1 3" type="ORF">Y6B3B.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAQ76502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129801.1">
        <property type="nucleotide sequence ID" value="NM_001136329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3KYB9"/>
    <dbReference type="PeptideAtlas" id="B3KYB9"/>
    <dbReference type="GeneID" id="173239"/>
    <dbReference type="KEGG" id="cel:CELE_Y6B3B.9"/>
    <dbReference type="AGR" id="WB:WBGene00012393"/>
    <dbReference type="CTD" id="173239"/>
    <dbReference type="WormBase" id="Y6B3B.9b">
        <property type="protein sequence ID" value="CE42733"/>
        <property type="gene ID" value="WBGene00012393"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044253_0_0_1"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012393">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3KYB9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAQ76502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y6B3B.9b"/>
        </source>
    </evidence>
    <sequence length="37" mass="4185" checksum="4728C424E340FF69" modified="2008-09-02" version="1">MAPGQRIETFTVVLDHHGSDKSRKRRAFDAAITLDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-04" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B5U8M1</accession>
    <name>B5U8M1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPX2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_R09A8.1</name>
        <name evidence="2 4" type="ORF">R09A8.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAR64675.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5U8M1"/>
    <dbReference type="AGR" id="WB:WBGene00011152"/>
    <dbReference type="WormBase" id="R09A8.1b">
        <property type="protein sequence ID" value="CE53101"/>
        <property type="gene ID" value="WBGene00011152"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285325_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011152">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5U8M1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR64675.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R09A8.1b"/>
        </source>
    </evidence>
    <sequence length="548" mass="62097" checksum="1B278A0FDDA5A3EB" modified="2019-06-05" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-04" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B5U8P0</accession>
    <name>B5U8P0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_D1086.12</name>
        <name evidence="1 3" type="ORF">D1086.12</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAR64662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5U8P0"/>
    <dbReference type="PeptideAtlas" id="B5U8P0"/>
    <dbReference type="AGR" id="WB:WBGene00044082"/>
    <dbReference type="WormBase" id="D1086.12c">
        <property type="protein sequence ID" value="CE43046"/>
        <property type="gene ID" value="WBGene00044082"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859095at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044082">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5U8P0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAR64662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="D1086.12c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="B5U8P0"/>
        </source>
    </evidence>
    <sequence length="141" mass="16430" checksum="8D47479C9F269E9B" modified="2008-11-04" version="1">MCTMISQTLGNWKLFFEAHHWGSPETLNLTSEEFNQINNICEREAISRSCFLPRLMLKIVCKKVDVLQSEFGKCMKDVQTMKIESEIFESFAKDFSFDGISKKCRLLQDPKMPTDIGETCGEEAQLSFTKKRRLLYYIFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-04" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B5U8P1</accession>
    <name>B5U8P1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T20D4.11-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_D1086.2</name>
        <name evidence="2 4" type="ORF">D1086.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAR64663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129890.1">
        <property type="nucleotide sequence ID" value="NM_001136418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5U8P1"/>
    <dbReference type="PeptideAtlas" id="B5U8P1"/>
    <dbReference type="GeneID" id="183931"/>
    <dbReference type="KEGG" id="cel:CELE_D1086.2"/>
    <dbReference type="AGR" id="WB:WBGene00008389"/>
    <dbReference type="CTD" id="183931"/>
    <dbReference type="WormBase" id="D1086.2b">
        <property type="protein sequence ID" value="CE42961"/>
        <property type="gene ID" value="WBGene00008389"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1490326_0_0_1"/>
    <dbReference type="OrthoDB" id="5781482at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008389">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5U8P1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002542">
        <property type="entry name" value="T20D4.11-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01579">
        <property type="entry name" value="DUF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T20D4.11-like" evidence="1">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR64663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="D1086.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="B5U8P1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17396" checksum="A0D903B38EFAC34B" modified="2008-11-04" version="1">MDHLIDRHLTDFSEALQSVLDEKNSFEMLRGEDEDNFMFVQGCETIERDLNVITCKKLRDKNRNVIKQCYELDLVGTPLSYCIQRKLNADKVANRCVKTYLKSKDTRELKRLFDTNLKCLVEGFTSLCGHEAGKVISENLKKIKYLKGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-04" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B5U8P4</accession>
    <name>B5U8P4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T20D4.11-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T08G5.3</name>
        <name evidence="2 4" type="ORF">T08G5.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAR64680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129908.1">
        <property type="nucleotide sequence ID" value="NM_001136436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5U8P4"/>
    <dbReference type="GeneID" id="179901"/>
    <dbReference type="KEGG" id="cel:CELE_T08G5.3"/>
    <dbReference type="AGR" id="WB:WBGene00011624"/>
    <dbReference type="CTD" id="179901"/>
    <dbReference type="WormBase" id="T08G5.3b">
        <property type="protein sequence ID" value="CE43011"/>
        <property type="gene ID" value="WBGene00011624"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1511950_0_0_1"/>
    <dbReference type="OrthoDB" id="5838832at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011624">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5U8P4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002542">
        <property type="entry name" value="T20D4.11-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01579">
        <property type="entry name" value="DUF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T20D4.11-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR64680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T08G5.3b"/>
        </source>
    </evidence>
    <sequence length="84" mass="9701" checksum="1DBA93AD8A04A745" modified="2008-11-04" version="1">MCSRFNFIIEKFTDCVPKLNNLTEIECVNEVFGPKSLKKTSNEKCDSLKEHRVCARKEVENACGDKMGKVLEENFDVELKMHKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-11-04" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B5U8P6</accession>
    <name>B5U8P6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homolog of Odr-2 (Two)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">hot-1</name>
        <name evidence="2" type="ORF">CELE_F43D2.4</name>
        <name evidence="4" type="ORF">F43D2.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAR64668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129897.1">
        <property type="nucleotide sequence ID" value="NM_001136425.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B5U8P6"/>
    <dbReference type="GeneID" id="179966"/>
    <dbReference type="KEGG" id="cel:CELE_F43D2.4"/>
    <dbReference type="AGR" id="WB:WBGene00001986"/>
    <dbReference type="CTD" id="179966"/>
    <dbReference type="WormBase" id="F43D2.4b">
        <property type="protein sequence ID" value="CE43028"/>
        <property type="gene ID" value="WBGene00001986"/>
        <property type="gene designation" value="hot-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117347_0_1_1"/>
    <dbReference type="OMA" id="DTARCYS"/>
    <dbReference type="OrthoDB" id="5824333at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001986">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B5U8P6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722:SF1">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002836753" evidence="1">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR64668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F43D2.4b"/>
        </source>
    </evidence>
    <sequence length="185" mass="20780" checksum="19FC9211568F9E27" modified="2008-11-04" version="1">MPSISYLLLTLMLLLLNGSWAQNSVLGPFLTSDTARCYSCMSKLYEAVWPSLSHIYKRPRNFTDDCDDERIAEGRVPIVHCPTICVSLFEQPNIAGVRIKGYIRGCMSDVLISGFNQTIVTWYRWMHRDSCRPYRKKELFKLGGESADDSTIDVCTCYADHCNGNSAASSLSIVSALLVLIAYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>B7FAS2</accession>
    <name>B7FAS2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Potassium voltage-gated channel subfamily KQT member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">KQT-like 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Voltage-gated potassium channel subunit Kv7.1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29 31" type="primary">kqt-3</name>
        <name evidence="29" type="ORF">CELE_Y54G9A.3</name>
        <name evidence="31" type="ORF">Y54G9A.3</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane raft</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAV31817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254404.1">
        <property type="nucleotide sequence ID" value="NM_001267475.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FAS2"/>
    <dbReference type="SMR" id="B7FAS2"/>
    <dbReference type="GeneID" id="191699"/>
    <dbReference type="AGR" id="WB:WBGene00002235"/>
    <dbReference type="CTD" id="191699"/>
    <dbReference type="WormBase" id="Y54G9A.3b">
        <property type="protein sequence ID" value="CE43414"/>
        <property type="gene ID" value="WBGene00002235"/>
        <property type="gene designation" value="kqt-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8879391at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002235">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B7FAS2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007213">
        <property type="term" value="P:G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000113">
        <property type="entry name" value="Potassium voltage-gated channel subfamily KQT member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000017">
        <property type="entry name" value="potassium voltage-gated channel subfamily KQT member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF14">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
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        <property type="entry name" value="KCNQCHANNEL"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
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    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="27">
        <location>
            <begin position="76"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="28">
        <location>
            <begin position="454"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="577"/>
            <end position="617"/>
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    </feature>
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        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004156"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00029687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00030121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00032659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="CAV31817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="WormBase" id="Y54G9A.3b"/>
        </source>
    </evidence>
    <sequence length="617" mass="70794" checksum="BF518FF1DC06C824" modified="2009-02-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>B7FAS5</accession>
    <name>B7FAS5_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4 6" type="primary">tbc-17</name>
        <name evidence="4" type="ORF">CELE_Y46G5A.1</name>
        <name evidence="6" type="ORF">Y46G5A.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254356.1">
        <property type="nucleotide sequence ID" value="NM_001267427.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FAS5"/>
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        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="B7FAS5"/>
    <dbReference type="GeneID" id="174900"/>
    <dbReference type="AGR" id="WB:WBGene00012894"/>
    <dbReference type="CTD" id="174900"/>
    <dbReference type="WormBase" id="Y46G5A.1c">
        <property type="protein sequence ID" value="CE43347"/>
        <property type="gene ID" value="WBGene00012894"/>
        <property type="gene designation" value="tbc-17"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_360252_0_0_1"/>
    <dbReference type="OMA" id="NFRRNGS"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012894">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B7FAS5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000010">
        <property type="entry name" value="Putative USP6 N-terminal-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000019">
        <property type="entry name" value="USP6 N-terminal like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF19">
        <property type="entry name" value="USP6 N-TERMINAL-LIKE PROTEIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="284"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAT01079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y46G5A.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="B7FAS5"/>
        </source>
    </evidence>
    <sequence length="777" mass="87597" checksum="8598D498B909F901" modified="2009-02-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>B7FAS8</accession>
    <name>B7FAS8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Endoplasmic oxidoreductin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21 23" type="primary">ero-1</name>
        <name evidence="21" type="ORF">CELE_Y105E8B.8</name>
        <name evidence="23" type="ORF">Y105E8B.8</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAV31790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001364667.1">
        <property type="nucleotide sequence ID" value="NM_001377680.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7FAS8"/>
    <dbReference type="SMR" id="B7FAS8"/>
    <dbReference type="PeptideAtlas" id="B7FAS8"/>
    <dbReference type="GeneID" id="173325"/>
    <dbReference type="AGR" id="WB:WBGene00001334"/>
    <dbReference type="CTD" id="173325"/>
    <dbReference type="WormBase" id="Y105E8B.8c">
        <property type="protein sequence ID" value="CE28787"/>
        <property type="gene ID" value="WBGene00001334"/>
        <property type="gene designation" value="ero-1"/>
    </dbReference>
    <dbReference type="OMA" id="NENCFTR"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="PhylomeDB" id="B7FAS8"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001334">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B7FAS8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
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        </source>
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    <sequence length="513" mass="59308" checksum="6EFB81E1667B950D" modified="2009-02-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C8JQR7</accession>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="454" mass="52741" checksum="DD4729CADD2932FA" modified="2009-10-13" version="1">MYHSKQANTKYIKKAQKLLDGSHQLRIDSHHVGSAGHGAGQGHGHKKEFGPAMILYYLASAFRALYPRLDDDFVDKLNYYYTTTILASFALLVSAKQYVGFPIQCWVPATFTDAMEQYTENYCWVQNTYWVPMQEDIPREIYSRRNRQIGYYQWVPFILAIEALLFYVPCILWRGLLYWHSGINLQGLVQMACDARLMDSEIKTRTVYTMARHMQDEVQLTNIDRQGHSRSCFSNLQLGANCGRHCGCYVTMLYIGIKVLYSANVLLQFFLLNHLLGSNDLAYGFSLLKDLMHAIEWEQTGMFPRVTLCDFEVRVLGNIHRHTVQCVLMINMFNEKIFLFLWFWFLTCGIVTVCNTMYWILIMFIPSQGMSFVRKYLRVLPDHPAKPIADDVTLRKFTNNFLRKDGVFMLRMISTHAGELMSSELILALWQDFNNVDRSPTQFWDAEHGQGTID</sequence>
</entry>
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    <accession>C8JQR8</accession>
    <name>C8JQR8_CAEEL</name>
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            <fullName evidence="12">Innexin</fullName>
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            <taxon>Rhabditidae</taxon>
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        </lineage>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CBB16220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001392896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8JQR8"/>
    <dbReference type="SMR" id="C8JQR8"/>
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        <property type="protein sequence ID" value="CE44028"/>
        <property type="gene ID" value="WBGene00006747"/>
        <property type="gene designation" value="unc-7"/>
    </dbReference>
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        <property type="project" value="WormBase"/>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
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        <property type="term" value="P:gap junction assembly"/>
        <property type="evidence" value="ECO:0000304"/>
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        <property type="term" value="P:locomotion"/>
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        <property type="term" value="P:monoatomic ion transmembrane transport"/>
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        <property type="term" value="P:regulation of nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
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    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
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        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF18">
        <property type="entry name" value="INNEXIN UNC-7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="INNEXIN"/>
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        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBB16220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="R07D5.1c"/>
        </source>
    </evidence>
    <sequence length="402" mass="47114" checksum="733906CD77F3E37E" modified="2009-10-13" version="1">MILYYLASAFRALYPRLDDDFVDKLNYYYTTTILASFALLVSAKQYVGFPIQCWVPATFTDAMEQYTENYCWVQNTYWVPMQEDIPREIYSRRNRQIGYYQWVPFILAIEALLFYVPCILWRGLLYWHSGINLQGLVQMACDARLMDSEIKTRTVYTMARHMQDEVQLTNIDRQGHSRSCFSNLQLGANCGRHCGCYVTMLYIGIKVLYSANVLLQFFLLNHLLGSNDLAYGFSLLKDLMHAIEWEQTGMFPRVTLCDFEVRVLGNIHRHTVQCVLMINMFNEKIFLFLWFWFLTCGIVTVCNTMYWILIMFIPSQGMSFVRKYLRVLPDHPAKPIADDVTLRKFTNNFLRKDGVFMLRMISTHAGELMSSELILALWQDFNNVDRSPTQFWDAEHGQGTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>C8JQR9</accession>
    <name>C8JQR9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CELE_F55A11.4</name>
        <name evidence="16 18" type="ORF">F55A11.4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBB16188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256365.1">
        <property type="nucleotide sequence ID" value="NM_001269436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8JQR9"/>
    <dbReference type="SMR" id="C8JQR9"/>
    <dbReference type="PeptideAtlas" id="C8JQR9"/>
    <dbReference type="GeneID" id="186276"/>
    <dbReference type="KEGG" id="cel:CELE_F55A11.4"/>
    <dbReference type="AGR" id="WB:WBGene00010077"/>
    <dbReference type="CTD" id="186276"/>
    <dbReference type="WormBase" id="F55A11.4a">
        <property type="protein sequence ID" value="CE44090"/>
        <property type="gene ID" value="WBGene00010077"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_2_0_1"/>
    <dbReference type="OMA" id="TRTNNMC"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="C8JQR9"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010077">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000369">
        <property type="entry name" value="Probable calcium-binding mitochondrial carrier CBG00135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000028">
        <property type="entry name" value="Putative calcium-binding mitochondrial carrier protein scamc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000003">
        <property type="entry name" value="Putative calcium-binding mitochondrial carrier protein scamc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="246"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="342"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="440"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBB16188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="F55A11.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="C8JQR9"/>
        </source>
    </evidence>
    <sequence length="535" mass="60138" checksum="9C03464F1C3FDC35" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C8JQS1</accession>
    <name>C8JQS1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">osm-7</name>
        <name evidence="3" type="ORF">CELE_T05D4.4</name>
        <name evidence="5" type="ORF">T05D4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CBB16233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255210.1">
        <property type="nucleotide sequence ID" value="NM_001268281.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8JQS1"/>
    <dbReference type="SMR" id="C8JQS1"/>
    <dbReference type="PeptideAtlas" id="C8JQS1"/>
    <dbReference type="GeneID" id="176790"/>
    <dbReference type="AGR" id="WB:WBGene00003887"/>
    <dbReference type="CTD" id="176790"/>
    <dbReference type="WormBase" id="T05D4.4b">
        <property type="protein sequence ID" value="CE43968"/>
        <property type="gene ID" value="WBGene00003887"/>
        <property type="gene designation" value="osm-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485924_0_0_1"/>
    <dbReference type="OrthoDB" id="5816579at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003887">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C8JQS1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053124">
        <property type="entry name" value="Notch_signaling_modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35015:SF4">
        <property type="entry name" value="PROTEIN CBR-OSM-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35015">
        <property type="entry name" value="PROTEIN CBR-OSM-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002990416" evidence="2">
        <location>
            <begin position="25"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBB16233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T05D4.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="C8JQS1"/>
        </source>
    </evidence>
    <sequence length="561" mass="63226" checksum="27BB938D820D897F" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>C8JQS2</accession>
    <name>C8JQS2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ddo-1</name>
        <name evidence="9" type="ORF">C47A10.5</name>
        <name evidence="7" type="ORF">CELE_C47A10.5</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBB16923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367222.1">
        <property type="nucleotide sequence ID" value="NM_001380853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8JQS2"/>
    <dbReference type="SMR" id="C8JQS2"/>
    <dbReference type="PeptideAtlas" id="C8JQS2"/>
    <dbReference type="GeneID" id="183530"/>
    <dbReference type="AGR" id="WB:WBGene00008127"/>
    <dbReference type="CTD" id="183530"/>
    <dbReference type="WormBase" id="C47A10.5b">
        <property type="protein sequence ID" value="CE44074"/>
        <property type="gene ID" value="WBGene00008127"/>
        <property type="gene designation" value="ddo-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1220669_0_0_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008127">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C8JQS2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008445">
        <property type="term" value="F:D-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047821">
        <property type="term" value="F:D-glutamate oxidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046416">
        <property type="term" value="P:D-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF28">
        <property type="entry name" value="D-ASPARTATE OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBB16923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C47A10.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="C8JQS2"/>
        </source>
    </evidence>
    <sequence length="227" mass="25470" checksum="BC663030860CA9E4" modified="2009-10-13" version="1">MTPKIAIIGEGVIGCSTALQVAQAVPDARVTVLSDRPFEQTCSFGPAGLFRIDDIANREFGKSTFDWFAHLHRTEKGDKTGVKLLSGHIQSDSKERLEQQQKAYGDIVYNFRFLEKREILDLFPNPSEHCIHYTAFASEGNKYVPYLKFQCQARGVEFLHRKVRDLEEGEQCCNRLGEAGKPLGSGNYGCRPERYFGKIRCTASGYEGAKNLRGVVRAQTSSEDYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C8JQS3</accession>
    <name>C8JQS3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C53A5.16</name>
        <name evidence="2" type="ORF">CELE_C53A5.16</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBB16079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256593.1">
        <property type="nucleotide sequence ID" value="NM_001269664.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8JQS3"/>
    <dbReference type="SMR" id="C8JQS3"/>
    <dbReference type="PeptideAtlas" id="C8JQS3"/>
    <dbReference type="GeneID" id="13216596"/>
    <dbReference type="KEGG" id="cel:CELE_C53A5.16"/>
    <dbReference type="AGR" id="WB:WBGene00194706"/>
    <dbReference type="CTD" id="13216596"/>
    <dbReference type="WormBase" id="C53A5.16a">
        <property type="protein sequence ID" value="CE43956"/>
        <property type="gene ID" value="WBGene00194706"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434989at2759"/>
    <dbReference type="PhylomeDB" id="C8JQS3"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00194706">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C8JQS3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="61"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBB16079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C53A5.16a"/>
        </source>
    </evidence>
    <sequence length="379" mass="44110" checksum="4ABCF64D45C2471F" modified="2009-10-13" version="1">MSRGLVLKIVQRSFSLNSPSTSSSNASFIDYSLSQGIFKDFLPKIDYHSHGFIEKLNEDLRSVHLIEKKIASVRNDLRKCFDPEIRLVPIGSAANLLLNNSSDLDLVLLPFKNSRQWKDFMKKFSENEQFRMSYMNKINLQLKAKKIGFSHDPYYKARIPLIRFFSKRWLQVDIQFGNIAPIRSSLFVRTCVEYDERVGLLIHWLTNKFQEAGILSSKNLKFSRYHVNILVIHFLQAIPYPVLPQIIQLSPWLSTKNDWNNAVKVLTRQGSVYVPNCSEVPNEQSVGALAVQLIDYFSQIDFHTNAIDTRGNVVDKLENDPLHFKIVDEFFAEPTCRVSEAPRLLTDLFKKLKEMVVQEKYEELFKYHQLEKKIKNKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8JQS6</accession>
    <name>C8JQS6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LEM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_W04E12.5</name>
        <name evidence="3 5" type="ORF">W04E12.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBB16271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256885.1">
        <property type="nucleotide sequence ID" value="NM_001269956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8JQS6"/>
    <dbReference type="SMR" id="C8JQS6"/>
    <dbReference type="PeptideAtlas" id="C8JQS6"/>
    <dbReference type="GeneID" id="189192"/>
    <dbReference type="AGR" id="WB:WBGene00012250"/>
    <dbReference type="CTD" id="189192"/>
    <dbReference type="WormBase" id="W04E12.5b">
        <property type="protein sequence ID" value="CE44014"/>
        <property type="gene ID" value="WBGene00012250"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104771_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012250">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C8JQS6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBB16271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W04E12.5b"/>
        </source>
    </evidence>
    <sequence length="185" mass="20922" checksum="E6935D6C5B61C3B4" modified="2009-10-13" version="1">MLSKMAKYPENEKNDGAAQEQTGPDEIFPFAPGTMFMAKTTDDLKLILEMLGMDEETKNFILKDREDELEKENREELLRSAPNNNRNAEYLTTSEPETDDDTDLELESKPVEPAVEAAKHRTDVEPEILGSAKMDDVATSASMTSLVWKFAILIFIPTFLAILLYFVPFDFSKSTNRFSKIRGAI</sequence>
</entry>
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    <accession>G5EBX6-2</accession>
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            <fullName evidence="4">Isoform b of Exosome complex component 10 homolog</fullName>
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            <fullName evidence="2">Cell death-related nuclease 3</fullName>
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        <name evidence="7" type="ORF">C14A4.4</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
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            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2003" name="Mol. Cell" volume="11" first="987" last="996">
            <title>Functional genomic analysis of apoptotic DNA degradation in C. elegans.</title>
            <authorList>
                <person name="Parrish J.Z."/>
                <person name="Xue D."/>
            </authorList>
            <dbReference type="PubMed" id="12718884"/>
            <dbReference type="DOI" id="10.1016/S1097-2765(03)00095-9"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CRN-5</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2018" name="Proc. Natl. Acad. Sci. U.S.A." volume="115" first="10082" last="10087">
            <title>Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA.</title>
            <authorList>
                <person name="Zhu C."/>
                <person name="Yan Q."/>
                <person name="Weng C."/>
                <person name="Hou X."/>
                <person name="Mao H."/>
                <person name="Liu D."/>
                <person name="Feng X."/>
                <person name="Guang S."/>
            </authorList>
            <dbReference type="PubMed" id="30224484"/>
            <dbReference type="DOI" id="10.1073/pnas.1800974115"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2021" name="Nucleic Acids Res." volume="49" first="9194" last="9210">
            <title>Antisense ribosomal siRNAs inhibit RNA polymerase I-directed transcription in C. elegans.</title>
            <authorList>
                <person name="Liao S."/>
                <person name="Chen X."/>
                <person name="Xu T."/>
                <person name="Jin Q."/>
                <person name="Xu Z."/>
                <person name="Xu D."/>
                <person name="Zhou X."/>
                <person name="Zhu C."/>
                <person name="Guang S."/>
                <person name="Feng X."/>
            </authorList>
            <dbReference type="PubMed" id="34365510"/>
            <dbReference type="DOI" id="10.1093/nar/gkab662"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2023" name="PLoS Genet." volume="19" first="e1010628" last="e1010628">
            <title>A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans.</title>
            <authorList>
                <person name="Xu T."/>
                <person name="Liao S."/>
                <person name="Huang M."/>
                <person name="Zhu C."/>
                <person name="Huang X."/>
                <person name="Jin Q."/>
                <person name="Xu D."/>
                <person name="Fu C."/>
                <person name="Chen X."/>
                <person name="Feng X."/>
                <person name="Guang S."/>
            </authorList>
            <dbReference type="PubMed" id="36763670"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1010628"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF ASP-303 AND GLU-305</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EBX6-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EBX6-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_062033"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001417852.1">
        <property type="nucleotide sequence ID" value="NM_001430931.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C14A4.4b">
        <property type="protein sequence ID" value="CE51406"/>
        <property type="gene ID" value="WBGene00000796"/>
        <property type="gene designation" value="crn-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q01780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="12718884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="36763670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="AAP57299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C14A4.4a"/>
        </source>
    </evidence>
    <sequence length="870" mass="100304" checksum="400454ED9B988C7F" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLG0</accession>
    <name>H2FLG0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Degenerin-like protein unc-105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">unc-105</name>
        <name evidence="18" type="ORF">C41C4.5</name>
        <name evidence="16" type="ORF">CELE_C41C4.5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCF23434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254139.1">
        <property type="nucleotide sequence ID" value="NM_001267210.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLG0"/>
    <dbReference type="GeneID" id="174306"/>
    <dbReference type="AGR" id="WB:WBGene00006832"/>
    <dbReference type="CTD" id="174306"/>
    <dbReference type="WormBase" id="C41C4.5h">
        <property type="protein sequence ID" value="CE46939"/>
        <property type="gene ID" value="WBGene00006832"/>
        <property type="gene designation" value="unc-105"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006832">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLG0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.470.10:FF:000004">
        <property type="entry name" value="Degenerin unc-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004726">
        <property type="entry name" value="Deg-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00867">
        <property type="entry name" value="deg-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF279">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN UNC-105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="891"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="915"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCF23434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="C41C4.5h"/>
        </source>
    </evidence>
    <sequence length="957" mass="108195" checksum="DE0888EB187DB39B" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLG4</accession>
    <name>H2FLG4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_M03C11.3</name>
        <name evidence="2 4" type="ORF">M03C11.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCF23352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255076.1">
        <property type="nucleotide sequence ID" value="NM_001268147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLG4"/>
    <dbReference type="PeptideAtlas" id="H2FLG4"/>
    <dbReference type="GeneID" id="187419"/>
    <dbReference type="AGR" id="WB:WBGene00010840"/>
    <dbReference type="CTD" id="187419"/>
    <dbReference type="WormBase" id="M03C11.3a">
        <property type="protein sequence ID" value="CE47046"/>
        <property type="gene ID" value="WBGene00010840"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_338962_0_0_1"/>
    <dbReference type="OrthoDB" id="5877532at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010840">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLG4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF23352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="M03C11.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2FLG4"/>
        </source>
    </evidence>
    <sequence length="835" mass="94095" checksum="AB2D6ED86DC27DFB" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLG6</accession>
    <name>H2FLG6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcellular chaperone signaling (X)cross tissue</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">txt-13</name>
        <name evidence="4" type="ORF">C06A1.2</name>
        <name evidence="2" type="ORF">CELE_C06A1.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCF23401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370877.1">
        <property type="nucleotide sequence ID" value="NM_001383936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLG6"/>
    <dbReference type="SMR" id="H2FLG6"/>
    <dbReference type="GeneID" id="182279"/>
    <dbReference type="KEGG" id="cel:CELE_C06A1.2"/>
    <dbReference type="AGR" id="WB:WBGene00007353"/>
    <dbReference type="CTD" id="182279"/>
    <dbReference type="WormBase" id="C06A1.2b">
        <property type="protein sequence ID" value="CE46975"/>
        <property type="gene ID" value="WBGene00007353"/>
        <property type="gene designation" value="txt-13"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5792300at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007353">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLG6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF23401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C06A1.2b"/>
        </source>
    </evidence>
    <sequence length="87" mass="10651" checksum="18B98024CE5AC2FD" modified="2012-03-21" version="1">MTLCGWPTECTELSCCESYIFRLYLLIFTFGVVIVAIIVSALWMLFEFRPNYRNRLRRQDTEEQHRLEERSFEETKYLRRFSELNEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-10-07" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYH4-2</accession>
    <name>HAM2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Zinc finger protein ham-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">HSN abnormal migration protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ham-2</name>
        <name evidence="4" type="ORF">C07A12.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="1999" name="Genes Dev." volume="13" first="472" last="483">
            <title>The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron.</title>
            <authorList>
                <person name="Baum P.D."/>
                <person name="Guenther C."/>
                <person name="Frank C.A."/>
                <person name="Pham B.V."/>
                <person name="Garriga G."/>
            </authorList>
            <dbReference type="PubMed" id="10049362"/>
            <dbReference type="DOI" id="10.1101/gad.13.4.472"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF SER-30 AND HIS-39</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KYH4-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2KYH4-2</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060687"/>
        </isoform>
        <isoform>
            <id>H2KYH4-3</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060688"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001294827.1">
        <property type="nucleotide sequence ID" value="NM_001307898.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C07A12.1c">
        <property type="protein sequence ID" value="CE39670"/>
        <property type="gene ID" value="WBGene00001821"/>
        <property type="gene designation" value="ham-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C07A12.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C07A12.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C07A12.1c"/>
        </source>
    </evidence>
    <sequence length="331" mass="36643" checksum="B1476F4AC5CC779A" modified="2012-03-21" version="1">MYRVHNITRMFMCRCCNWAFPDKTSLHIHMQSMLKNGTPGEAAVLAKSSDVVDSTSESGSPRQSPPFSPDLLMQKRMLQVAANNNNIGSIFPTLLKSPDSKSMFPLDLSNMGPSQFLSAWLANNPINTAALNLAAQQTPSKDSIQSSNISDYDDLEVQTTEEDIKFEVESSDVSPRSVIVKTEPTFKRELEHDADIDVEGDDGEPPLKMTIDDKNIHISHDQPSPTVSDSHISGGSSSHSGESLKCFDCQVARGKLVAVEDKCRAYEKTIRELQVQVDFLRKIQPNPMPPVMLPPPMMPMPSPGPNNLFQNPAMRMLLNNLIHMNRPSVVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-10-07" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYH4-3</accession>
    <name>HAM2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Zinc finger protein ham-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">HSN abnormal migration protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ham-2</name>
        <name evidence="4" type="ORF">C07A12.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="1999" name="Genes Dev." volume="13" first="472" last="483">
            <title>The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron.</title>
            <authorList>
                <person name="Baum P.D."/>
                <person name="Guenther C."/>
                <person name="Frank C.A."/>
                <person name="Pham B.V."/>
                <person name="Garriga G."/>
            </authorList>
            <dbReference type="PubMed" id="10049362"/>
            <dbReference type="DOI" id="10.1101/gad.13.4.472"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF SER-30 AND HIS-39</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KYH4-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2KYH4-3</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060688"/>
        </isoform>
        <isoform>
            <id>H2KYH4-2</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060687"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024363.2">
        <property type="nucleotide sequence ID" value="NM_001029192.7"/>
    </dbReference>
    <dbReference type="WormBase" id="C07A12.1a">
        <property type="protein sequence ID" value="CE39669"/>
        <property type="gene ID" value="WBGene00001821"/>
        <property type="gene designation" value="ham-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C07A12.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C07A12.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C07A12.1c"/>
        </source>
    </evidence>
    <sequence length="390" mass="43473" checksum="CCF1A328C9E93383" modified="2012-03-21" version="1">MPYRAELKRPDLKGSFPCSICQKVFCHSSSLSRHRMQAHFKSYTCTTCNNEIPSNDTLRSHMYRVHNITRMFMCRCCNWAFPDKTSLHIHMQSMLKNGTPGEAAVLAKSSDDSTSESGSPRQSPPFSPDLLMQKRMLQVAANNNNIGSIFPTLLKSPDSKSMFPLDLSNMGPSQFLSAWLANNPINTAALNLAAQQTPSKDSIQSSNISDYDDLEVQTTEEDIKFEVESSDVSPRSVIVKTEPTFKRELEHDADIDVEGDDGEPPLKMTIDDKNIHISHDQPSPTVSDSHISGGSSSHSGESLKCFDCQVARGKLVAVEDKCRAYEKTIRELQVQVDFLRKIQPNPMPPVMLPPPMMPMPSPGPNNLFQNPAMRMLLNNLIHMNRPSVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZU0</accession>
    <name>H2KZU0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH La-type RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">larp-5</name>
        <name evidence="6" type="ORF">CELE_T12F5.5</name>
        <name evidence="8" type="ORF">T12F5.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD69787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_871824.3">
        <property type="nucleotide sequence ID" value="NM_182024.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZU0"/>
    <dbReference type="SMR" id="H2KZU0"/>
    <dbReference type="PeptideAtlas" id="H2KZU0"/>
    <dbReference type="GeneID" id="171942"/>
    <dbReference type="AGR" id="WB:WBGene00004147"/>
    <dbReference type="CTD" id="171942"/>
    <dbReference type="WormBase" id="T12F5.5b">
        <property type="protein sequence ID" value="CE39278"/>
        <property type="gene ID" value="WBGene00004147"/>
        <property type="gene designation" value="larp-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391409_0_0_1"/>
    <dbReference type="OrthoDB" id="10046764at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004147">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZU0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08031">
        <property type="entry name" value="LARP_4_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12430">
        <property type="entry name" value="RRM_LARP4_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058699">
        <property type="entry name" value="RRM_LARP4/4B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF131">
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        <location>
            <begin position="619"/>
            <end position="629"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD69787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="T12F5.5b"/>
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    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZU0"/>
        </source>
    </evidence>
    <sequence length="696" mass="77719" checksum="BAD7D6386E1835D9" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZU1</accession>
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        <submittedName>
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            <strain evidence="14 15">Bristol N2</strain>
        </source>
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        <subcellularLocation>
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        <property type="gene ID" value="WBGene00003620"/>
        <property type="gene designation" value="nhr-21"/>
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    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="102"/>
        </location>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCD69789.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="F21D12.1a"/>
        </source>
    </evidence>
    <sequence length="448" mass="49940" checksum="0D13FB965C9A59A7" modified="2012-03-21" version="1">MGPRSKSTMRLMSKDSSQSLVANHKATLFCAVCGDTALGKHYGVTACNGCKGFFRRSIWKNRTYACRYQGKCGVAKEQRNACRSCRLKECIKVGMNPRAVQGDIDTASTSSASPNLVSVEMHPYTKEVECQTEVSTISSHPTSPSTLPFVSSGSSICSVSSSCSSVSTVYSNCLAMLPPNPSLPKYDYLLASLSRIFERVDEHAPEPLPNTYSFEHAFYNPHLICNRTKLTPTGERIATLPEVLQDFRRIFVLFTDVLSILPEFSRLDESDRMVLAKSRFSFFYWWLTCCWTAKVGCPGVCYANGAYHPSDKRQQAFPDVNYRGVTELSVETVSKPLANINITDAEMLVGSVFAIFYEYPLPPKVSYASTHILNEARDLYTQCMITVSPYSQLEAKSASRLAEISLIFSSITNLKYLTSDNIELSDVLHVMEVDQLITEAFDVHRPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZU2</accession>
    <name>H2KZU2_CAEEL</name>
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        <submittedName>
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        </submittedName>
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    <organism evidence="14 15">
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        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="H2KZU2"/>
    <dbReference type="SMR" id="H2KZU2"/>
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    <dbReference type="AGR" id="WB:WBGene00003620"/>
    <dbReference type="CTD" id="174202"/>
    <dbReference type="WormBase" id="F21D12.1c">
        <property type="protein sequence ID" value="CE33377"/>
        <property type="gene ID" value="WBGene00003620"/>
        <property type="gene designation" value="nhr-21"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817395at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
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    </dbReference>
    <dbReference type="Bgee" id="WBGene00003620">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052499">
        <property type="entry name" value="C.elegans_NHRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630:SF3">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="179"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD69791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="F21D12.1c"/>
        </source>
    </evidence>
    <sequence length="440" mass="49079" checksum="3FCD9BA359D0C577" modified="2012-03-21" version="1">MRLMSKDSSQSLVANHKATLFCAVCGDTALGKHYGVTACNGCKGFFRRSIWKNRTYACRYQGKCGVAKEQRNACRSCRLKECIKVGMNPRAVQGDIDTASTSSASPNLVSVEMHPYTNFREVECQTEVSTISSHPTSPSTLPFVSSGSSICSVSSSCSSVSTVYSNCLAMLPPNPSLPKYDYLLASLSRIFERVDEHAPEPLPNTYSFEHAFYNPHLICNRTKLTPTGERIATLPEVLQDFRRIFVLFTDVLSILPEFSRLDESDRMVLAKSRFSFFYWWLTCCWTAKVGCPGVCYANGAYHPSDKRQQAFPDVKGVTELSVETVSKPLANINITDAEMLVGSVFAIFYEYPLPPKVSYASTHILNEARDLYTQCMITVSPYSQLEAKSASRLAEISLIFSSITNLKYLTSDNIELSDVLHVMEVDQLITEAFDVHRPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZU3</accession>
    <name>H2KZU3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">nhr-21</name>
        <name evidence="14" type="ORF">CELE_F21D12.1</name>
        <name evidence="16" type="ORF">F21D12.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD69792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022103.1">
        <property type="nucleotide sequence ID" value="NM_001026932.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZU3"/>
    <dbReference type="SMR" id="H2KZU3"/>
    <dbReference type="GeneID" id="174202"/>
    <dbReference type="AGR" id="WB:WBGene00003620"/>
    <dbReference type="CTD" id="174202"/>
    <dbReference type="WormBase" id="F21D12.1d">
        <property type="protein sequence ID" value="CE27988"/>
        <property type="gene ID" value="WBGene00003620"/>
        <property type="gene designation" value="nhr-21"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007368_3_3_1"/>
    <dbReference type="OrthoDB" id="5817395at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003620">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZU3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052499">
        <property type="entry name" value="C.elegans_NHRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630:SF3">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="185"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD69792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="F21D12.1d"/>
        </source>
    </evidence>
    <sequence length="446" mass="49635" checksum="0101E15D7DA449D5" modified="2012-03-21" version="1">MGPRSKSTMRLMSKDSSQSLVANHKATLFCAVCGDTALGKHYGVTACNGCKGFFRRSIWKNRTYACRYQGKCGVAKEQRNACRSCRLKECIKVGMNPRAVQGDIDTASTSSASPNLVSVEMHPYTKEVECQTEVSTISSHPTSPSTLPFVSSGSSICSVSSSCSSVSTVYSNCLAMLPPNPSLPKYDYLLASLSRIFERVDEHAPEPLPNTYSFEHAFYNPHLICNRTKLTPTGERIATLPEVLQDFRRIFVLFTDVLSILPEFSRLDESDRMVLAKSRFSFFYWWLTCCWTAKVGCPGVCYANGAYHPSDKRQQAFPDVKGVTELSVETVSKPLANINITDAEMLVGSVFAIFYEYPLPPKVSYASTHILNEARDLYTQCMITVSPYSQLEAKSASRLAEISLIFSSITNLKYLTSDNIELSDVLHVMEVDQLITEAFDVHRPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZU6</accession>
    <name>H2KZU6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein furry C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">sax-2</name>
        <name evidence="3" type="ORF">CELE_F21H11.2</name>
        <name evidence="5" type="ORF">F21H11.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD69846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741132.2">
        <property type="nucleotide sequence ID" value="NM_171118.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZU6"/>
    <dbReference type="SMR" id="H2KZU6"/>
    <dbReference type="PeptideAtlas" id="H2KZU6"/>
    <dbReference type="GeneID" id="175697"/>
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    </dbReference>
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            <begin position="72"/>
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        <location>
            <begin position="691"/>
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            <begin position="219"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="252"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF19421"/>
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        <source>
            <dbReference type="EMBL" id="CCD69846.1"/>
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</entry>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="AGR" id="WB:WBGene00017732"/>
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        <property type="gene ID" value="WBGene00017732"/>
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        <property type="component" value="Chromosome I"/>
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZU9">
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    </dbReference>
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        <property type="entry name" value="PHAGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33651">
        <property type="entry name" value="PROTEIN CBG06246"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="CCD69885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="F23C8.3a"/>
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    </evidence>
    <sequence length="116" mass="13179" checksum="5B7D8D7182B7F4FC" modified="2012-03-21" version="1">MDGNQYEAIFLNYFRGIFPNADNLNVKCVKRMSEQQMKTTISRHGMRCTVLNGKDKISSYTVKKIVETPGKREYYGVRDIFAFKLLDMMGVGPKVHFVSNGEVGDDVGLFIVTEDD</sequence>
</entry>
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        <submittedName>
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            <strain evidence="2 3">Bristol N2</strain>
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="535" mass="62557" checksum="CFEA8794E188C104" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZV3</accession>
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        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
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        <name evidence="2 4" type="primary">fbxl-4</name>
        <name evidence="2" type="ORF">CELE_T28B4.1</name>
        <name evidence="4" type="ORF">T28B4.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
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    <dbReference type="EMBL" id="BX284606">
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        <property type="gene ID" value="WBGene00020884"/>
        <property type="gene designation" value="fbxl-4"/>
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    <dbReference type="HOGENOM" id="CLU_030060_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
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    <dbReference type="Bgee" id="WBGene00020884">
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    </dbReference>
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        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD69937.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZV3"/>
        </source>
    </evidence>
    <sequence length="518" mass="60126" checksum="A8A30C911618ED47" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZV7</accession>
    <name>H2KZV7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho GTPase-activating protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CELE_T04C9.1</name>
        <name evidence="9 11" type="ORF">T04C9.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD69973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741164.2">
        <property type="nucleotide sequence ID" value="NM_171870.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZV7"/>
    <dbReference type="SMR" id="H2KZV7"/>
    <dbReference type="PeptideAtlas" id="H2KZV7"/>
    <dbReference type="GeneID" id="175849"/>
    <dbReference type="AGR" id="WB:WBGene00020209"/>
    <dbReference type="CTD" id="175849"/>
    <dbReference type="WormBase" id="T04C9.1b">
        <property type="protein sequence ID" value="CE32715"/>
        <property type="gene ID" value="WBGene00020209"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011532_2_0_1"/>
    <dbReference type="OrthoDB" id="3183924at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020209">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZV7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01249">
        <property type="entry name" value="BAR-PH_GRAF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07602">
        <property type="entry name" value="BAR_RhoGAP_OPHN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11882">
        <property type="entry name" value="SH3_GRAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000147">
        <property type="entry name" value="Protein CBG09025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000006">
        <property type="entry name" value="Rho GTPase activating protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000055">
        <property type="entry name" value="rho GTPase-activating protein 26 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047234">
        <property type="entry name" value="GRAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047225">
        <property type="entry name" value="PH_GRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552">
        <property type="entry name" value="OLIGOPHRENIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN GRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="269"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="403"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="804"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD69973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="T04C9.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZV7"/>
        </source>
    </evidence>
    <sequence length="863" mass="97211" checksum="3EEEDF2F813750A5" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZV8</accession>
    <name>H2KZV8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cysteine-rich protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">mlp-1</name>
        <name evidence="14" type="ORF">CELE_T04C9.4</name>
        <name evidence="16" type="ORF">T04C9.4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD69978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_498300.2">
        <property type="nucleotide sequence ID" value="NM_065899.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZV8"/>
    <dbReference type="STRING" id="6239.T04C9.4b.1"/>
    <dbReference type="PaxDb" id="6239-T04C9.4b"/>
    <dbReference type="PeptideAtlas" id="H2KZV8"/>
    <dbReference type="GeneID" id="175847"/>
    <dbReference type="AGR" id="WB:WBGene00003375"/>
    <dbReference type="CTD" id="175847"/>
    <dbReference type="WormBase" id="T04C9.4b">
        <property type="protein sequence ID" value="CE31590"/>
        <property type="gene ID" value="WBGene00003375"/>
        <property type="gene designation" value="mlp-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1679758at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003375">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZV8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09404">
        <property type="entry name" value="LIM1_MLP84B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000054">
        <property type="entry name" value="Cysteine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD69978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="T04C9.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZV8"/>
        </source>
    </evidence>
    <sequence length="113" mass="12235" checksum="3F48F28812CEDB93" modified="2012-03-21" version="1">MPFKPVEHPKCPKCGKSVYAAEEMSAGGYKWHKFCFKCNMCNKLLDSCTVAPHEAELYCKQCHGRKFGPKGVGFGLGAGCLTTDSGEKFGGSKQTNRPMTAEAFTAPINPSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZX4</accession>
    <name>H2KZX4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">gldi-2</name>
        <name evidence="20" type="ORF">CELE_T13C2.6</name>
        <name evidence="22" type="ORF">T13C2.6</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD70327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_495387.2">
        <property type="nucleotide sequence ID" value="NM_062986.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZX4"/>
    <dbReference type="SMR" id="H2KZX4"/>
    <dbReference type="PeptideAtlas" id="H2KZX4"/>
    <dbReference type="GeneID" id="174116"/>
    <dbReference type="AGR" id="WB:WBGene00020481"/>
    <dbReference type="CTD" id="174116"/>
    <dbReference type="WormBase" id="T13C2.6a">
        <property type="protein sequence ID" value="CE36567"/>
        <property type="gene ID" value="WBGene00020481"/>
        <property type="gene designation" value="gldi-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008163_2_1_1"/>
    <dbReference type="OrthoDB" id="664115at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020481">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZX4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003563322" evidence="18">
        <location>
            <begin position="22"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="581"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="624"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="669"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="866"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="866"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCD70327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="T13C2.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZX4"/>
        </source>
    </evidence>
    <sequence length="909" mass="101165" checksum="3337C37A0E85E1E2" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZX6</accession>
    <name>H2KZX6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F31F7.1</name>
        <name evidence="2 4" type="ORF">F31F7.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD70363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZX6"/>
    <dbReference type="AGR" id="WB:WBGene00017964"/>
    <dbReference type="WormBase" id="F31F7.1b">
        <property type="protein sequence ID" value="CE33063"/>
        <property type="gene ID" value="WBGene00017964"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1588001_0_0_1"/>
    <dbReference type="OrthoDB" id="6418983at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017964">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZX6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009658">
        <property type="entry name" value="DUF1248"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47408:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47408">
        <property type="entry name" value="PROTEIN CBG01304-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06852">
        <property type="entry name" value="DUF1248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD70363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F31F7.1b"/>
        </source>
    </evidence>
    <sequence length="168" mass="19671" checksum="1056675A032ABE71" modified="2012-03-21" version="1">MGVTTDLNVPKGIKVVLNPTQEYFDQFQEWITETERWNYRRTEYKLWCTAFEKFWLYMAIDEENDECVSVVSLALQRNSDGKKLYSIGNYYCVPEWRGRGVSNKLFVQVMKHVGKENCTLFGAVKMSPLYATRFNFALMNEFWHMFADIDVVDLVIPAMPNGFTCKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZX8</accession>
    <name>H2KZX8_CAEEL</name>
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        <submittedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rga-8</name>
        <name evidence="5" type="ORF">CELE_Y34B4A.8</name>
        <name evidence="7" type="ORF">Y34B4A.8</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD70390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257019.1">
        <property type="nucleotide sequence ID" value="NM_001270090.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZX8"/>
    <dbReference type="SMR" id="H2KZX8"/>
    <dbReference type="PeptideAtlas" id="H2KZX8"/>
    <dbReference type="GeneID" id="180799"/>
    <dbReference type="AGR" id="WB:WBGene00021324"/>
    <dbReference type="CTD" id="180799"/>
    <dbReference type="WormBase" id="Y34B4A.8a">
        <property type="protein sequence ID" value="CE30216"/>
        <property type="gene ID" value="WBGene00021324"/>
        <property type="gene designation" value="rga-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_424048_0_0_1"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="PhylomeDB" id="H2KZX8"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021324">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZX8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04386">
        <property type="entry name" value="RhoGAP_nadrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000081">
        <property type="entry name" value="Rho GTPase Activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF14">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 92B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="241"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD70390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y34B4A.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZX8"/>
        </source>
    </evidence>
    <sequence length="604" mass="67984" checksum="34EAD4C11DC7E1A7" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K8F7R4</accession>
    <name>K8F7R4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class D (Delta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srd-11</name>
        <name evidence="2" type="ORF">CELE_F53F4.9</name>
        <name evidence="4" type="ORF">F53F4.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCO25591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263883.1">
        <property type="nucleotide sequence ID" value="NM_001276954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K8F7R4"/>
    <dbReference type="GeneID" id="191801"/>
    <dbReference type="KEGG" id="cel:CELE_F53F4.9"/>
    <dbReference type="AGR" id="WB:WBGene00005089"/>
    <dbReference type="CTD" id="191801"/>
    <dbReference type="WormBase" id="F53F4.9b">
        <property type="protein sequence ID" value="CE48025"/>
        <property type="gene ID" value="WBGene00005089"/>
        <property type="gene designation" value="srd-11"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2266148_0_0_1"/>
    <dbReference type="OrthoDB" id="5797606at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005089">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="K8F7R4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCO25591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F53F4.9b"/>
        </source>
    </evidence>
    <sequence length="103" mass="11856" checksum="4E403FE64ECFDFFF" modified="2013-02-06" version="1">MALTWQAMIPGFYGMSIVSYVIGQFFFNHPVFEYLTLTGFLFMPVLSPLSCLIFIQIYQKRVLSWWYKMIGNPIPDEWLTVLNATRTNATSSVAPSNEIKSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K8F7S4</accession>
    <name>K8F7S4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T28B11.1</name>
        <name evidence="2 4" type="ORF">T28B11.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCO25601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263857.1">
        <property type="nucleotide sequence ID" value="NM_001276928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K8F7S4"/>
    <dbReference type="PeptideAtlas" id="K8F7S4"/>
    <dbReference type="GeneID" id="179487"/>
    <dbReference type="KEGG" id="cel:CELE_T28B11.1"/>
    <dbReference type="AGR" id="WB:WBGene00012117"/>
    <dbReference type="CTD" id="179487"/>
    <dbReference type="WormBase" id="T28B11.1b">
        <property type="protein sequence ID" value="CE47990"/>
        <property type="gene ID" value="WBGene00012117"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_461697_0_0_1"/>
    <dbReference type="OrthoDB" id="5799818at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012117">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="K8F7S4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCO25601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T28B11.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="K8F7S4"/>
        </source>
    </evidence>
    <sequence length="536" mass="61192" checksum="999C3D01EDB9915E" modified="2013-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>K8F804</accession>
    <name>K8F804_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">cup-14</name>
        <name evidence="11" type="ORF">CELE_Y51H1A.2</name>
        <name evidence="13" type="ORF">Y51H1A.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCO25899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="168" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB16527.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y57G11C.24a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="O18250"/>
        </source>
    </evidence>
    <sequence length="862" mass="98634" checksum="A35819553F23A416" modified="2006-01-10" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>O44503</accession>
    <name>O44503_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">aass-1</name>
        <name evidence="10" type="ORF">CELE_R02D3.1</name>
        <name evidence="12" type="ORF">R02D3.1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD73165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T15063">
        <property type="entry name" value="T15063"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_499884.1">
        <property type="nucleotide sequence ID" value="NM_067483.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O44503"/>
    <dbReference type="SMR" id="O44503"/>
    <dbReference type="PeptideAtlas" id="O44503"/>
    <dbReference type="GeneID" id="176842"/>
    <dbReference type="UCSC" id="R02D3.1">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00019819"/>
    <dbReference type="CTD" id="176842"/>
    <dbReference type="WormBase" id="R02D3.1a">
        <property type="protein sequence ID" value="CE18095"/>
        <property type="gene ID" value="WBGene00019819"/>
        <property type="gene designation" value="aass-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005231_0_1_1"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="PhylomeDB" id="O44503"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019819">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O44503">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000087">
        <property type="entry name" value="alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000004">
        <property type="entry name" value="AminoAdipate-Semialdehyde Synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="203"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD73165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="R02D3.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="O44503"/>
        </source>
    </evidence>
    <sequence length="934" mass="103752" checksum="CF985E127DDA69D5" modified="1998-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2026-01-28" version="181" xmlns="https://uniprot.org/uniprot">
    <accession>P17486-2</accession>
    <name>EGL5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform a of Homeobox protein egl-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1 2">Abdominal-B homolog egl-5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Egg-laying defective protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Homeobox protein ceh-11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">egl-5</name>
        <name evidence="6" type="synonym">ceh-11</name>
        <name evidence="6" type="ORF">C08C3.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1989" name="Genetics" volume="121" first="703" last="721">
            <title>Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying.</title>
            <authorList>
                <person name="Desai C."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="2721931"/>
            <dbReference type="DOI" id="10.1093/genetics/121.4.703"/>
        </citation>
        <scope>MUTAGENESIS OF ARG-163</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1990" name="Nucleic Acids Res." volume="18" first="2033" last="2036">
            <title>Cloning and analysis of three new homeobox genes from the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Schaller D."/>
                <person name="Wittmann C."/>
                <person name="Spicher A."/>
                <person name="Mueller F."/>
                <person name="Tobler H."/>
            </authorList>
            <dbReference type="PubMed" id="1970877"/>
            <dbReference type="DOI" id="10.1093/nar/18.8.2033"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 111-185</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1991" name="Development" volume="111" first="921" last="932">
            <title>Control of cell fate in the tail region of C. elegans by the gene egl-5.</title>
            <authorList>
                <person name="Chisholm A."/>
            </authorList>
            <dbReference type="PubMed" id="1879361"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ARG-163</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1993" name="Cell" volume="74" first="29" last="42">
            <title>A homeotic gene cluster patterns the anteroposterior body axis of C. elegans.</title>
            <authorList>
                <person name="Wang B.B."/>
                <person name="Mueller-Immergluck M.M."/>
                <person name="Austin J."/>
                <person name="Robinson N.T."/>
                <person name="Chisholm A.D."/>
                <person name="Kenyon C."/>
            </authorList>
            <dbReference type="PubMed" id="8101474"/>
            <dbReference type="DOI" id="10.1016/0092-8674(93)90292-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ARG-163</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
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                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
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                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1999" name="Dev. Biol." volume="207" first="215" last="228">
            <title>Patterning of Caenorhabditis elegans posterior structures by the Abdominal-B homolog, egl-5.</title>
            <authorList>
                <person name="Ferreira H.B."/>
                <person name="Zhang Y."/>
                <person name="Zhao C."/>
                <person name="Emmons S.W."/>
            </authorList>
            <dbReference type="PubMed" id="10049576"/>
            <dbReference type="DOI" id="10.1006/dbio.1998.9124"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ARG-163</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2003" name="Development" volume="130" first="3831" last="3840">
            <title>The Caenorhabditis elegans spalt-like gene sem-4 restricts touch cell fate by repressing the selector Hox gene egl-5 and the effector gene mec-3.</title>
            <authorList>
                <person name="Toker A.S."/>
                <person name="Teng Y."/>
                <person name="Ferreira H.B."/>
                <person name="Emmons S.W."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="12835398"/>
            <dbReference type="DOI" id="10.1242/dev.00398"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ARG-163</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2007" name="Dev. Biol." volume="308" first="583" last="592">
            <title>Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5.</title>
            <authorList>
                <person name="Deng H."/>
                <person name="Sun Y."/>
                <person name="Zhang Y."/>
                <person name="Luo X."/>
                <person name="Hou W."/>
                <person name="Yan L."/>
                <person name="Chen Y."/>
                <person name="Tian E."/>
                <person name="Han J."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="17574230"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.05.021"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2008" name="Genetics" volume="179" first="887" last="898">
            <title>The T-box gene tbx-2, the homeobox gene egl-5 and the asymmetric cell division gene ham-1 specify neural fate in the HSN/PHB lineage.</title>
            <authorList>
                <person name="Singhvi A."/>
                <person name="Frank C.A."/>
                <person name="Garriga G."/>
            </authorList>
            <dbReference type="PubMed" id="18505863"/>
            <dbReference type="DOI" id="10.1534/genetics.108.088948"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2009" name="Dev. Biol." volume="329" first="16" last="24">
            <title>The C. elegans Hox gene egl-5 is required for correct development of the hermaphrodite hindgut and for the response to rectal infection by Microbacterium nematophilum.</title>
            <authorList>
                <person name="Nicholas H.R."/>
                <person name="Hodgkin J."/>
            </authorList>
            <dbReference type="PubMed" id="19232338"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2009.01.044"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2010" name="Dev. Biol." volume="344" first="827" last="835">
            <title>EGL-5/ABD-B plays an instructive role in male cell fate determination in the C. elegans somatic gonad.</title>
            <authorList>
                <person name="Kalis A.K."/>
                <person name="Murphy M.W."/>
                <person name="Zarkower D."/>
            </authorList>
            <dbReference type="PubMed" id="20553900"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.05.516"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH POP-1</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ARG-163</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P17486-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_015688"/>
        </isoform>
        <isoform>
            <id>P17486-1</id>
            <name evidence="6">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P17486-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_015689"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_498697.3">
        <property type="nucleotide sequence ID" value="NM_066296.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C08C3.1a">
        <property type="protein sequence ID" value="CE29076"/>
        <property type="gene ID" value="WBGene00001174"/>
        <property type="gene designation" value="egl-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="17574230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="8101474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C08C3.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C08C3.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C08C3.1c"/>
        </source>
    </evidence>
    <sequence length="219" mass="24697" checksum="2B6F718A35768E6E" modified="2005-09-27" version="4">MNTSTSAFDFGSSTASSAATSTTSSQPDANDHLSRLAAMTQGVGKEDPETSSTPSTEASLYPGISAAYMQSYGWPQNYNYFGQPLGPATFPGWPQCYPNTAWPNYASSKKGRQTYQRYQTSVLEAKFQQSSYVSKKQREELRLQTQLTDRQIKIWFQNRRMKAKKEKQRVDDHTEHTPLLPANPPKGMGMDMDDEKKWQMAHWPPAAAHNPYQYPLCPP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2026-01-28" version="181" xmlns="https://uniprot.org/uniprot">
    <accession>P17486-3</accession>
    <name>EGL5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform c of Homeobox protein egl-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1 2">Abdominal-B homolog egl-5</fullName>
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        <alternativeName>
            <fullName evidence="6">Egg-laying defective protein 5</fullName>
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        <alternativeName>
            <fullName evidence="6">Homeobox protein ceh-11</fullName>
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    <gene>
        <name evidence="6" type="primary">egl-5</name>
        <name evidence="6" type="synonym">ceh-11</name>
        <name evidence="6" type="ORF">C08C3.1</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1989" name="Genetics" volume="121" first="703" last="721">
            <title>Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying.</title>
            <authorList>
                <person name="Desai C."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="2721931"/>
            <dbReference type="DOI" id="10.1093/genetics/121.4.703"/>
        </citation>
        <scope>MUTAGENESIS OF ARG-163</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1990" name="Nucleic Acids Res." volume="18" first="2033" last="2036">
            <title>Cloning and analysis of three new homeobox genes from the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Schaller D."/>
                <person name="Wittmann C."/>
                <person name="Spicher A."/>
                <person name="Mueller F."/>
                <person name="Tobler H."/>
            </authorList>
            <dbReference type="PubMed" id="1970877"/>
            <dbReference type="DOI" id="10.1093/nar/18.8.2033"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 111-185</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1991" name="Development" volume="111" first="921" last="932">
            <title>Control of cell fate in the tail region of C. elegans by the gene egl-5.</title>
            <authorList>
                <person name="Chisholm A."/>
            </authorList>
            <dbReference type="PubMed" id="1879361"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ARG-163</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1993" name="Cell" volume="74" first="29" last="42">
            <title>A homeotic gene cluster patterns the anteroposterior body axis of C. elegans.</title>
            <authorList>
                <person name="Wang B.B."/>
                <person name="Mueller-Immergluck M.M."/>
                <person name="Austin J."/>
                <person name="Robinson N.T."/>
                <person name="Chisholm A.D."/>
                <person name="Kenyon C."/>
            </authorList>
            <dbReference type="PubMed" id="8101474"/>
            <dbReference type="DOI" id="10.1016/0092-8674(93)90292-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ARG-163</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1999" name="Dev. Biol." volume="207" first="215" last="228">
            <title>Patterning of Caenorhabditis elegans posterior structures by the Abdominal-B homolog, egl-5.</title>
            <authorList>
                <person name="Ferreira H.B."/>
                <person name="Zhang Y."/>
                <person name="Zhao C."/>
                <person name="Emmons S.W."/>
            </authorList>
            <dbReference type="PubMed" id="10049576"/>
            <dbReference type="DOI" id="10.1006/dbio.1998.9124"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ARG-163</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2003" name="Development" volume="130" first="3831" last="3840">
            <title>The Caenorhabditis elegans spalt-like gene sem-4 restricts touch cell fate by repressing the selector Hox gene egl-5 and the effector gene mec-3.</title>
            <authorList>
                <person name="Toker A.S."/>
                <person name="Teng Y."/>
                <person name="Ferreira H.B."/>
                <person name="Emmons S.W."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="12835398"/>
            <dbReference type="DOI" id="10.1242/dev.00398"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ARG-163</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2007" name="Dev. Biol." volume="308" first="583" last="592">
            <title>Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5.</title>
            <authorList>
                <person name="Deng H."/>
                <person name="Sun Y."/>
                <person name="Zhang Y."/>
                <person name="Luo X."/>
                <person name="Hou W."/>
                <person name="Yan L."/>
                <person name="Chen Y."/>
                <person name="Tian E."/>
                <person name="Han J."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="17574230"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.05.021"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2008" name="Genetics" volume="179" first="887" last="898">
            <title>The T-box gene tbx-2, the homeobox gene egl-5 and the asymmetric cell division gene ham-1 specify neural fate in the HSN/PHB lineage.</title>
            <authorList>
                <person name="Singhvi A."/>
                <person name="Frank C.A."/>
                <person name="Garriga G."/>
            </authorList>
            <dbReference type="PubMed" id="18505863"/>
            <dbReference type="DOI" id="10.1534/genetics.108.088948"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2009" name="Dev. Biol." volume="329" first="16" last="24">
            <title>The C. elegans Hox gene egl-5 is required for correct development of the hermaphrodite hindgut and for the response to rectal infection by Microbacterium nematophilum.</title>
            <authorList>
                <person name="Nicholas H.R."/>
                <person name="Hodgkin J."/>
            </authorList>
            <dbReference type="PubMed" id="19232338"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2009.01.044"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2010" name="Dev. Biol." volume="344" first="827" last="835">
            <title>EGL-5/ABD-B plays an instructive role in male cell fate determination in the C. elegans somatic gonad.</title>
            <authorList>
                <person name="Kalis A.K."/>
                <person name="Murphy M.W."/>
                <person name="Zarkower D."/>
            </authorList>
            <dbReference type="PubMed" id="20553900"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.05.516"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH POP-1</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ARG-163</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P17486-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_015688"/>
        </isoform>
        <isoform>
            <id>P17486-1</id>
            <name evidence="6">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P17486-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_015689"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021167.1">
        <property type="nucleotide sequence ID" value="NM_001025996.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C08C3.1c">
        <property type="protein sequence ID" value="CE34523"/>
        <property type="gene ID" value="WBGene00001174"/>
        <property type="gene designation" value="egl-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="17574230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="8101474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C08C3.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C08C3.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C08C3.1c"/>
        </source>
    </evidence>
    <sequence length="222" mass="25073" checksum="6DF47CEF048BDD1A" modified="2005-09-27" version="4">MNTSTSAFDFGSSTASSAATSTTSSQPDANDHLSRLAAMTQGVGKEDPETSSTPSTEASLYPVSAAYMQSYGWPQNYNYFGQPLGPATFPGWPQCYPNTAWPNYGELFASSKKGRQTYQRYQTSVLEAKFQQSSYVSKKQREELRLQTQLTDRQIKIWFQNRRMKAKKEKQRVDDHTEHTPLLPANPPKGMGMDMDDEKKWQMAHWPPAAAHNPYQYPLCPP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>P34531-2</accession>
    <name>CLP1H_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of CAP-Gly domain-containing linker protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clip-1</name>
        <name evidence="1" type="ORF">M01A8.2</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34531-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34531-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_016341"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022683.1">
        <property type="nucleotide sequence ID" value="NM_001027512.7"/>
    </dbReference>
    <dbReference type="WormBase" id="M01A8.2b">
        <property type="protein sequence ID" value="CE37262"/>
        <property type="gene ID" value="WBGene00010796"/>
        <property type="gene designation" value="clip-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="M01A8.2a"/>
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            <fullName>Isoform b of FMRFamide-like neuropeptides 1</fullName>
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            <recommendedName>
                <fullName>PNFLRF-amide</fullName>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference key="1">
        <citation type="journal article" date="1992" name="J. Neurosci." volume="12" first="2356" last="2361">
            <title>Alternatively spliced transcripts of the flp-1 gene encode distinct FMRFamide-like peptides in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Rosoff M.L."/>
                <person name="Buerglin T.R."/>
                <person name="Li C."/>
            </authorList>
            <dbReference type="PubMed" id="1607945"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND B)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Peptides" volume="14" first="331" last="338">
            <title>The flp-1 propeptide is processed into multiple, highly similar FMRFamide-like peptides in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Rosoff M.L."/>
                <person name="Doble K.E."/>
                <person name="Price D.A."/>
                <person name="Li C."/>
            </authorList>
            <dbReference type="PubMed" id="8483810"/>
            <dbReference type="DOI" id="10.1016/0196-9781(93)90049-M"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 71-76; 89-98; 101-108; 111-120; 123-130; 133-142; 146-154 AND 168-173</scope>
        <scope>MASS SPECTROMETRY</scope>
        <scope>AMIDATION AT TYR-76; PHE-98; PHE-108; PHE-120; PHE-130; PHE-142; PHE-154 AND PHE-173</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="J. Comp. Neurol." volume="475" first="540" last="550">
            <title>Expression and regulation of an FMRFamide-related neuropeptide gene family in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kim K."/>
                <person name="Li C."/>
            </authorList>
            <dbReference type="PubMed" id="15236235"/>
            <dbReference type="DOI" id="10.1002/cne.20189"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Biochem. Biophys. Res. Commun." volume="335" first="76" last="86">
            <title>Discovering neuropeptides in Caenorhabditis elegans by two dimensional liquid chromatography and mass spectrometry.</title>
            <authorList>
                <person name="Husson S.J."/>
                <person name="Clynen E."/>
                <person name="Baggerman G."/>
                <person name="De Loof A."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="16061202"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2005.07.044"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 133-142 AND 146-154</scope>
        <scope>AMIDATION AT PHE-142 AND PHE-154</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="J. Neurobiol." volume="65" first="304" last="319">
            <title>Role of a FMRFamide-like family of neuropeptides in the pharyngeal nervous system of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Papaioannou S."/>
                <person name="Marsden D."/>
                <person name="Franks C.J."/>
                <person name="Walker R.J."/>
                <person name="Holden-Dye L."/>
            </authorList>
            <dbReference type="PubMed" id="16187307"/>
            <dbReference type="DOI" id="10.1002/neu.20201"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2006" name="Peptides" volume="27" first="1291" last="1296">
            <title>FMRFamide related peptide ligands activate the Caenorhabditis elegans orphan GPCR Y59H11AL.1.</title>
            <authorList>
                <person name="Mertens I."/>
                <person name="Clinckspoor I."/>
                <person name="Janssen T."/>
                <person name="Nachman R."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="16377032"/>
            <dbReference type="DOI" id="10.1016/j.peptides.2005.11.017"/>
        </citation>
        <scope>FUNCTION (PNFMRY-AMIDE)</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003472" last="E1003472">
            <title>Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans.</title>
            <authorList>
                <person name="Stawicki T.M."/>
                <person name="Takayanagi-Kiya S."/>
                <person name="Zhou K."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="23658528"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003472"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PROTEOLYTIC CLEAVAGE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2017" name="Elife" volume="6" first="0" last="0">
            <title>Luqin-like RYamide peptides regulate food-evoked responses in C. elegans.</title>
            <authorList>
                <person name="Ohno H."/>
                <person name="Yoshida M."/>
                <person name="Sato T."/>
                <person name="Kato J."/>
                <person name="Miyazato M."/>
                <person name="Kojima M."/>
                <person name="Ida T."/>
                <person name="Iino Y."/>
            </authorList>
            <dbReference type="PubMed" id="28847365"/>
            <dbReference type="DOI" id="10.7554/eLife.28877"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 168-173</scope>
        <scope>AMIDATION AT PHE-173</scope>
        <scope>MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P41855-3</id>
            <name>c</name>
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        <isoform>
            <id>P41855-1</id>
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        <isoform>
            <id>P41855-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_001563"/>
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    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Expressed at about a twofold higher level than isoform Long.</text>
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    <accession>P41855-3</accession>
    <name>FLP01_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of FMRFamide-like neuropeptides 1</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName>PNFMRY-amide</fullName>
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        <component>
            <recommendedName>
                <fullName>AGSDPNFLRF-amide</fullName>
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        </component>
        <component>
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                <fullName>SQPNFLRF-amide</fullName>
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        </component>
        <component>
            <recommendedName>
                <fullName>ASGDPNFLRF-amide</fullName>
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        <component>
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                <fullName>SDPNFLRF-amide</fullName>
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        <component>
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                <fullName>AAADPNFLRF-amide</fullName>
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        <component>
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                <fullName>PNFLRF-amide</fullName>
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    <organism>
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            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference key="1">
        <citation type="journal article" date="1992" name="J. Neurosci." volume="12" first="2356" last="2361">
            <title>Alternatively spliced transcripts of the flp-1 gene encode distinct FMRFamide-like peptides in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Rosoff M.L."/>
                <person name="Buerglin T.R."/>
                <person name="Li C."/>
            </authorList>
            <dbReference type="PubMed" id="1607945"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND B)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Peptides" volume="14" first="331" last="338">
            <title>The flp-1 propeptide is processed into multiple, highly similar FMRFamide-like peptides in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Rosoff M.L."/>
                <person name="Doble K.E."/>
                <person name="Price D.A."/>
                <person name="Li C."/>
            </authorList>
            <dbReference type="PubMed" id="8483810"/>
            <dbReference type="DOI" id="10.1016/0196-9781(93)90049-M"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 71-76; 89-98; 101-108; 111-120; 123-130; 133-142; 146-154 AND 168-173</scope>
        <scope>MASS SPECTROMETRY</scope>
        <scope>AMIDATION AT TYR-76; PHE-98; PHE-108; PHE-120; PHE-130; PHE-142; PHE-154 AND PHE-173</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="J. Comp. Neurol." volume="475" first="540" last="550">
            <title>Expression and regulation of an FMRFamide-related neuropeptide gene family in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kim K."/>
                <person name="Li C."/>
            </authorList>
            <dbReference type="PubMed" id="15236235"/>
            <dbReference type="DOI" id="10.1002/cne.20189"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Biochem. Biophys. Res. Commun." volume="335" first="76" last="86">
            <title>Discovering neuropeptides in Caenorhabditis elegans by two dimensional liquid chromatography and mass spectrometry.</title>
            <authorList>
                <person name="Husson S.J."/>
                <person name="Clynen E."/>
                <person name="Baggerman G."/>
                <person name="De Loof A."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="16061202"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2005.07.044"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 133-142 AND 146-154</scope>
        <scope>AMIDATION AT PHE-142 AND PHE-154</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="J. Neurobiol." volume="65" first="304" last="319">
            <title>Role of a FMRFamide-like family of neuropeptides in the pharyngeal nervous system of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Papaioannou S."/>
                <person name="Marsden D."/>
                <person name="Franks C.J."/>
                <person name="Walker R.J."/>
                <person name="Holden-Dye L."/>
            </authorList>
            <dbReference type="PubMed" id="16187307"/>
            <dbReference type="DOI" id="10.1002/neu.20201"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2006" name="Peptides" volume="27" first="1291" last="1296">
            <title>FMRFamide related peptide ligands activate the Caenorhabditis elegans orphan GPCR Y59H11AL.1.</title>
            <authorList>
                <person name="Mertens I."/>
                <person name="Clinckspoor I."/>
                <person name="Janssen T."/>
                <person name="Nachman R."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="16377032"/>
            <dbReference type="DOI" id="10.1016/j.peptides.2005.11.017"/>
        </citation>
        <scope>FUNCTION (PNFMRY-AMIDE)</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003472" last="E1003472">
            <title>Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans.</title>
            <authorList>
                <person name="Stawicki T.M."/>
                <person name="Takayanagi-Kiya S."/>
                <person name="Zhou K."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="23658528"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003472"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PROTEOLYTIC CLEAVAGE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2017" name="Elife" volume="6" first="0" last="0">
            <title>Luqin-like RYamide peptides regulate food-evoked responses in C. elegans.</title>
            <authorList>
                <person name="Ohno H."/>
                <person name="Yoshida M."/>
                <person name="Sato T."/>
                <person name="Kato J."/>
                <person name="Miyazato M."/>
                <person name="Kojima M."/>
                <person name="Ida T."/>
                <person name="Iino Y."/>
            </authorList>
            <dbReference type="PubMed" id="28847365"/>
            <dbReference type="DOI" id="10.7554/eLife.28877"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 168-173</scope>
        <scope>AMIDATION AT PHE-173</scope>
        <scope>MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P41855-1</id>
            <name>a</name>
            <sequence type="displayed"/>
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        <isoform>
            <id>P41855-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_001563"/>
        </isoform>
        <isoform>
            <id>P41855-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_020150"/>
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    </comment>
    <dbReference type="RefSeq" id="NP_872078.1">
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    <dbReference type="WormBase" id="F23B2.5c">
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<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="187" xmlns="https://uniprot.org/uniprot">
    <accession>Q03563-2</accession>
    <name>SPK1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Serine/threonine-protein kinase spk-1</fullName>
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    <gene>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="EMBO J." volume="19" first="1625" last="1637">
            <title>Functional characterization of SR and SR-related genes in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Longman D."/>
                <person name="Johnstone I.L."/>
                <person name="Caceres J.F."/>
            </authorList>
            <dbReference type="PubMed" id="10747030"/>
            <dbReference type="DOI" id="10.1093/emboj/19.7.1625"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2000" name="Mech. Dev." volume="99" first="51" last="64">
            <title>SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline development.</title>
            <authorList>
                <person name="Kuroyanagi H."/>
                <person name="Kimura T."/>
                <person name="Wada K."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
                <person name="Hagiwara M."/>
            </authorList>
            <dbReference type="PubMed" id="11091073"/>
            <dbReference type="DOI" id="10.1016/S0925-4773(00)00477-9"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q03563-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q03563-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_012277 VSP_012310 VSP_012309 VSP_012278 VSP_012279"/>
        </isoform>
        <isoform>
            <id>Q03563-2</id>
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            <sequence type="described" ref="VSP_012309 VSP_012280 VSP_012310 VSP_012277 VSP_012278"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="RefSeq" id="NP_001021133.1">
        <property type="nucleotide sequence ID" value="NM_001025962.3"/>
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    <dbReference type="WormBase" id="B0464.5b">
        <property type="protein sequence ID" value="CE20457"/>
        <property type="gene ID" value="WBGene00004980"/>
        <property type="gene designation" value="spk-1"/>
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    <proteinExistence type="evidence at transcript level"/>
    <sequence length="698" mass="78111" checksum="9486843BD2FB5D0F" modified="2004-12-21" version="3"> </sequence>
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    <accession>Q03563-3</accession>
    <name>SPK1_CAEEL</name>
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        <recommendedName>
            <fullName>Isoform c of Serine/threonine-protein kinase spk-1</fullName>
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        <name type="primary">spk-1</name>
        <name type="synonym">rsk-1</name>
        <name type="synonym">srk-1</name>
        <name type="ORF">B0464.5</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="EMBO J." volume="19" first="1625" last="1637">
            <title>Functional characterization of SR and SR-related genes in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Longman D."/>
                <person name="Johnstone I.L."/>
                <person name="Caceres J.F."/>
            </authorList>
            <dbReference type="PubMed" id="10747030"/>
            <dbReference type="DOI" id="10.1093/emboj/19.7.1625"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2000" name="Mech. Dev." volume="99" first="51" last="64">
            <title>SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline development.</title>
            <authorList>
                <person name="Kuroyanagi H."/>
                <person name="Kimura T."/>
                <person name="Wada K."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
                <person name="Hagiwara M."/>
            </authorList>
            <dbReference type="PubMed" id="11091073"/>
            <dbReference type="DOI" id="10.1016/S0925-4773(00)00477-9"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q03563-2</id>
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        </isoform>
        <isoform>
            <id>Q03563-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q03563-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_012309 VSP_012279 VSP_012278 VSP_012310 VSP_012277"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="RefSeq" id="NP_001021134.1">
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    <dbReference type="WormBase" id="B0464.5c">
        <property type="protein sequence ID" value="CE36373"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
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    <proteinExistence type="evidence at transcript level"/>
    <sequence length="774" mass="86441" checksum="7C204A739D809FE9" modified="2004-12-21" version="3"> </sequence>
</entry>
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    <accession>Q09511-2</accession>
    <name>RSP4_CAEEL</name>
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        <recommendedName>
            <fullName>Isoform b of Probable splicing factor, arginine/serine-rich 4</fullName>
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        <alternativeName>
            <fullName>CeSC35</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>RNA-binding protein srp-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rsp-4</name>
        <name type="synonym">srp-2</name>
        <name type="ORF">EEED8.7</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="EMBO J." volume="19" first="1625" last="1637">
            <title>Functional characterization of SR and SR-related genes in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Longman D."/>
                <person name="Johnstone I.L."/>
                <person name="Caceres J.F."/>
            </authorList>
            <dbReference type="PubMed" id="10747030"/>
            <dbReference type="DOI" id="10.1093/emboj/19.7.1625"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Mech. Dev." volume="95" first="67" last="76">
            <title>Unique and redundant functions of SR proteins, a conserved family of splicing factors, in Caenorhabditis elegans development.</title>
            <authorList>
                <person name="Kawano T."/>
                <person name="Fujita M."/>
                <person name="Sakamoto H."/>
            </authorList>
            <dbReference type="PubMed" id="10906451"/>
            <dbReference type="DOI" id="10.1016/S0925-4773(00)00339-7"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09511-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09511-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_012275 VSP_012276"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_495014.1">
        <property type="nucleotide sequence ID" value="NM_062613.4"/>
    </dbReference>
    <dbReference type="WormBase" id="EEED8.7b">
        <property type="protein sequence ID" value="CE27910"/>
        <property type="gene ID" value="WBGene00004701"/>
        <property type="gene designation" value="rsp-4"/>
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        <property type="component" value="Chromosome II"/>
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    <proteinExistence type="predicted"/>
    <sequence length="126" mass="14071" checksum="7424543E2DF4FC47" modified="1996-11-01" version="1">MSRGGGGDRRAAPDINGLTSLKIDNLSYQTTPNDLRRTFERYGDIGDVHIPRDKYSRQSKGFGFVRFYERRDAEHALDRTDGKLVDGRELRVTLAKYDRPSDERGGRGGGGGRRRTAAEPDVAELS</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q18478</accession>
    <name>Q18478_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-cell activation inhibitor, mitochondrial</fullName>
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    <gene>
        <name evidence="3 5" type="ORF">C35B8.3</name>
        <name evidence="3" type="ORF">CELE_C35B8.3</name>
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    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
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    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD66771.1"/>
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    <dbReference type="PIR" id="T15777">
        <property type="entry name" value="T15777"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379776.1">
        <property type="nucleotide sequence ID" value="NM_001392818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18478"/>
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    <dbReference type="PeptideAtlas" id="Q18478"/>
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    <dbReference type="CTD" id="181152"/>
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        <property type="entry name" value="DUF4460"/>
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    <dbReference type="PANTHER" id="PTHR31596:SF1">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
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    <dbReference type="Pfam" id="PF14687">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF14688">
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        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
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    <feature type="domain" description="DUF4461" evidence="2">
        <location>
            <begin position="161"/>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14688"/>
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        <source>
            <dbReference type="EMBL" id="CCD66771.1"/>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C35B8.3a"/>
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    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="470" mass="53575" checksum="F7C94FC43C07ABEC" modified="2001-10-01" version="2">MFTSPSKQKSLWEISKRCISSNEVAQALRPFLFLVHPDKYAKFPEIQTQNEKSLQIFNGYMNDLFPVSPSLKPTKVSFSIADKQSTTFRKININLTGTDPAKIVRDALESCELSTSELKFKDTGIRSTRTGSGGLGFTTSNVEEDLLRSYLKRKKATVITNLYDSLTNKRDEAMRKTREAKSLLVSIKDDISDLKYRTQLKDVVWQMAWEESHMRRCISNVNRMIDQATPETRTVIEKAFFKNVLRFGRGSFICCDGSIQLGADHVPEQWENVCQEYQIRKRQIPLLKETAKQLEQTFGGAQILLPHFKGLAQTLTQLQTLTVRVWKKEALLRRVEDSAKNSMLEIVTSYDELAIGLDGRLYIPCNVDVPSLVQFLEENSKKAIEINQQMHHLINELEFARDECIKELKLTGLRWEQAFTPEALIQCVYRLTHCSDDVRNLVSGLSIVISASPSIYVTSDGTLSIPLNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-12-07" modified="2025-10-08" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q5W7E3</accession>
    <name>Q5W7E3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_Y67D8A.2</name>
        <name evidence="7 9" type="ORF">Y67D8A.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD73136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023555.1">
        <property type="nucleotide sequence ID" value="NM_001028384.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5W7E3"/>
    <dbReference type="SMR" id="Q5W7E3"/>
    <dbReference type="PeptideAtlas" id="Q5W7E3"/>
    <dbReference type="GeneID" id="177092"/>
    <dbReference type="KEGG" id="cel:CELE_Y67D8A.2"/>
    <dbReference type="UCSC" id="Y67D8A.2a.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022059"/>
    <dbReference type="CTD" id="177092"/>
    <dbReference type="WormBase" id="Y67D8A.2c">
        <property type="protein sequence ID" value="CE37733"/>
        <property type="gene ID" value="WBGene00022059"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089831_0_0_1"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022059">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q5W7E3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="6">
        <location>
            <begin position="62"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD73136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y67D8A.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q5W7E3"/>
        </source>
    </evidence>
    <sequence length="245" mass="28086" checksum="10804B41C1D366A4" modified="2004-12-07" version="1">MPSRNDGPALLKRRSAKPFAGNLRLRRLTKAYLEPLDDNNKEMSPTVAKIDQIYDLTQELIVQCQSVTSGLFPRYSKDRDVGYVKDSIYCAMACWACSVAYKRLDDDRGRQTELRQTAVKTMRGILFSWMQQSKNLDAFKSQNSSEFALHARFDLSSGMGLETPNDDLHYGHLQMDLVALYLLTLVQMISAGCKVIYTHHEVNFIQNLVFYIERTYRTPDFGMWERGTRYNNGKPELHASSLGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-12-07" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q5W7E6</accession>
    <name>Q5W7E6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">clec-82</name>
        <name evidence="2" type="ORF">CELE_Y54G2A.8</name>
        <name evidence="4" type="ORF">Y54G2A.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD83495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380093.1">
        <property type="nucleotide sequence ID" value="NM_001392272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5W7E6"/>
    <dbReference type="SMR" id="Q5W7E6"/>
    <dbReference type="GeneID" id="177064"/>
    <dbReference type="UCSC" id="Y54G2A.8a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021873"/>
    <dbReference type="CTD" id="177064"/>
    <dbReference type="WormBase" id="Y54G2A.8b">
        <property type="protein sequence ID" value="CE37728"/>
        <property type="gene ID" value="WBGene00021873"/>
        <property type="gene designation" value="clec-82"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046757_0_0_1"/>
    <dbReference type="OrthoDB" id="5806460at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021873">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q5W7E6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055578">
        <property type="entry name" value="DUF7154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23062:SF3">
        <property type="entry name" value="ANF_RECEPTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23062">
        <property type="entry name" value="HYPOTHETICAL PROTEIN C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23673">
        <property type="entry name" value="DUF7154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD83495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y54G2A.8b"/>
        </source>
    </evidence>
    <sequence length="430" mass="47974" checksum="E6FB44AB7A078FC6" modified="2004-12-07" version="1">MVNLQLSYNDALDWCHYKNPVVQSNLATIPDPSTANFLASYARTAFGVDSGQFWIGLRRNSSGGIPWWWDDGSSLRWTNFGTQLSHDYVAQSIVNAKWNTFLGTEKNFFVCSYNPNFITTEYPTTTDDTSCQPESPVTLLFAYSNDLDPDVLESTWGATDFGEYPNFAAYATVRFDLRVAEDIAYHTTIESANTYITSHPPDPTLGFTSTSVGSDSLSIVENFYKNQQLSVCGSVVLLLSKRNPNETEISQIVSLVRRHHGLVHAIMSVNPSGGSQPKALYNLVSKTNGVAAFEQDSEFSDFILHLPMFLTPYPLYCANPKVSGTNSTELPPLSVSSEDSYYTIMVVQDHYPSDSFQSSQLKWWPSGQQPFGFSLTKSDLIGNDANTWITLEATSYNMTLDYSYATTVPQAIQIRIFSGSPLDYWLPYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q9GRY3</accession>
    <name>Q9GRY3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_Y59A8B.21</name>
        <name evidence="7 9" type="ORF">Y59A8B.21</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAC14416.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_507519.2">
        <property type="nucleotide sequence ID" value="NM_075118.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9GRY3"/>
    <dbReference type="SMR" id="Q9GRY3"/>
    <dbReference type="PaxDb" id="6239-Y59A8B.21"/>
    <dbReference type="GeneID" id="190398"/>
    <dbReference type="UCSC" id="Y59A8B.21">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013353"/>
    <dbReference type="CTD" id="190398"/>
    <dbReference type="WormBase" id="Y59A8B.21a">
        <property type="protein sequence ID" value="CE41523"/>
        <property type="gene ID" value="WBGene00013353"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_6_1"/>
    <dbReference type="OMA" id="HQLWLMW"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="PhylomeDB" id="Q9GRY3"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013353">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9GRY3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17353">
        <property type="entry name" value="MFS_OFA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC14416.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y59A8B.21a"/>
        </source>
    </evidence>
    <sequence length="460" mass="51171" checksum="F68578883404D383" modified="2007-10-02" version="3">MSVCRRRRDPIADTIYSFSPFNRICVILFGAVSIHLTIGTYHTFGNMLPYMASYMRNFTDPSVRIEHMMWIPTFQGCFPFAMVIGGLTSSTFSPRVSAFIGCFLVTSSVALSAYAIQHSFALFFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVNPLNLPATKDGYFLQPELLHRVPALFTKLAVIYGIMQAMALIVVCDPPFRKSRSTESILEEDDEDMDEDYERPVFDNDEDTTIQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELGKMAFLFWLVGTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSIFPFCAFIFISCIQWTPQGKLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2025-10-08" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>Q9GRY9</accession>
    <name>Q9GRY9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nova-1</name>
        <name evidence="5" type="ORF">CELE_Y59A8B.10</name>
        <name evidence="7" type="ORF">Y59A8B.10</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-320508">
            <id>Q9GRY9</id>
        </interactant>
        <interactant intactId="EBI-320476">
            <id>P91277</id>
            <label>hrpk-1</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-320508">
            <id>Q9GRY9</id>
        </interactant>
        <interactant intactId="EBI-311961">
            <id>Q9XVS2</id>
            <label>sup-46</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>4</experiments>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAC14410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256769.1">
        <property type="nucleotide sequence ID" value="NM_001269840.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9GRY9"/>
    <dbReference type="SMR" id="Q9GRY9"/>
    <dbReference type="DIP" id="DIP-24651N"/>
    <dbReference type="IntAct" id="Q9GRY9">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q9GRY9"/>
    <dbReference type="GeneID" id="180183"/>
    <dbReference type="KEGG" id="cel:CELE_Y59A8B.10"/>
    <dbReference type="UCSC" id="Y59A8B.10">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013347"/>
    <dbReference type="CTD" id="180183"/>
    <dbReference type="WormBase" id="Y59A8B.10a">
        <property type="protein sequence ID" value="CE26206"/>
        <property type="gene ID" value="WBGene00013347"/>
        <property type="gene designation" value="nova-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_6_1_1"/>
    <dbReference type="OMA" id="REKCADQ"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="PhylomeDB" id="Q9GRY9"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013347">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9GRY9">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22435">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
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    </dbReference>
    <dbReference type="CDD" id="cd22436">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
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    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="KH-I_NOVA_rpt2"/>
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        <property type="entry name" value="KH_dom"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="132"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
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            <end position="261"/>
        </location>
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            <end position="307"/>
        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC14410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y59A8B.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q9GRY9"/>
        </source>
    </evidence>
    <sequence length="413" mass="42115" checksum="4431E90B9EC82789" modified="2001-03-01" version="1">MAEEFTEDSKTQQGVKRTQDASDGPANKKAHFGGEEEGGDHLSIKILIPSNAVGAIIGKGGEAMRNLKNDNNCRVQMSKNSETYPGTSERICLVKGRLNNIMAVIESIQDKIREKCADQGGSDAFDHKNTSRGAEIKIVMPNTSAGMVIGKSGANIKDIREQFGCQIQVYPKAGSVEAKTSLERVVTVAHDEASALLQAASRVLEKVASDPHHASEINKEDFGKGSGPSGSANSGPSGGGGGGGGGGQSNNNSSFSSVPAFNGGGGGGGGMNVGAAGFGGGGGQGYGGPQFGGQGGPQFGNGNNKYPMSGLGNNELLSFLDNLQSTLRTSGFNEQSVSEVMQAMQVLAKYNIMGLGLGLGVAAMAQMRTGQESQGMSANHGSAGFGDGYGQGGVQGGPQGPQGGGGDQSYWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N4S9</accession>
    <name>Q9N4S9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Saccharopine dehydrogenase-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y50D4B.2</name>
        <name evidence="1 3" type="ORF">Y50D4B.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD72850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_503379.3">
        <property type="nucleotide sequence ID" value="NM_070978.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N4S9"/>
    <dbReference type="PaxDb" id="6239-Y50D4B.2"/>
    <dbReference type="GeneID" id="190094"/>
    <dbReference type="UCSC" id="Y50D4B.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021741"/>
    <dbReference type="CTD" id="190094"/>
    <dbReference type="WormBase" id="Y50D4B.2a">
        <property type="protein sequence ID" value="CE24401"/>
        <property type="gene ID" value="WBGene00021741"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031002_3_0_1"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="PhylomeDB" id="Q9N4S9"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021741">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N4S9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD72850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y50D4B.2a"/>
        </source>
    </evidence>
    <sequence length="217" mass="24583" checksum="BACFA2AA19CACAB0" modified="2004-03-01" version="4">MPNDIENGTVIPPRRGVVWKIEEKELQGFAIPFPGADLSVMVRSQYYDATVRKSRPVHLSSYFQLDTRFKTYRLILWGAITRAFALASFTRRILLKYPDQCSFRMFKKSGPSAQQIAEASFTYWFFGYGYKETIPLDQQHERKVDRKVVATCKGPDLAYMAASGCVLSAALALVKDKNNLPKEGGVYTPAAAFGDSKIYDYLATFGINFHLESEYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N534</accession>
    <name>Q9N534_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1 atypical kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y32H12A.7</name>
        <name evidence="3 5" type="ORF">Y32H12A.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73965.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_498150.2">
        <property type="nucleotide sequence ID" value="NM_065749.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N534"/>
    <dbReference type="STRING" id="6239.Y32H12A.7.1"/>
    <dbReference type="PaxDb" id="6239-Y32H12A.7.1"/>
    <dbReference type="PeptideAtlas" id="Q9N534"/>
    <dbReference type="GeneID" id="175741"/>
    <dbReference type="UCSC" id="Y32H12A.7.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021315"/>
    <dbReference type="CTD" id="175741"/>
    <dbReference type="WormBase" id="Y32H12A.7a">
        <property type="protein sequence ID" value="CE46976"/>
        <property type="gene ID" value="WBGene00021315"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_6_1_1"/>
    <dbReference type="InParanoid" id="Q9N534"/>
    <dbReference type="OMA" id="SMVRTHH"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="PhylomeDB" id="Q9N534"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021315">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="189"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD73965.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y32H12A.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N534"/>
        </source>
    </evidence>
    <sequence length="580" mass="66410" checksum="9B7C8DDFD9386A10" modified="2012-03-21" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q9NES9</accession>
    <name>Q9NES9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Iron-sulfur cluster assembly 1 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y39B6A.3</name>
        <name evidence="4 6" type="ORF">Y39B6A.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAC51075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T45057">
        <property type="entry name" value="T45057"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741696.1">
        <property type="nucleotide sequence ID" value="NM_171606.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9NES9"/>
    <dbReference type="SMR" id="Q9NES9"/>
    <dbReference type="GeneID" id="180262"/>
    <dbReference type="UCSC" id="Y39B6A.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012666"/>
    <dbReference type="CTD" id="180262"/>
    <dbReference type="WormBase" id="Y39B6A.3a">
        <property type="protein sequence ID" value="CE21678"/>
        <property type="gene ID" value="WBGene00012666"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012666">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9NES9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC51075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y39B6A.3a"/>
        </source>
    </evidence>
    <sequence length="129" mass="14190" checksum="7620A66508F9EA1D" modified="2000-10-01" version="1">MSKFGGATAKVIKGALKVRQTRAALTLTNEAVSRIRVLLAQQNDANALKIGVRQKGCNGLTYTLEYAKDKQKFDEEVEQDGIKVWIEPKAQLSLLGSEMDYVTDKLSSEFVFRNPNIKGTCGCGESFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="166" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XU07</accession>
    <name>Q9XU07_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">twk-40</name>
        <name evidence="11" type="ORF">CELE_T28A8.1</name>
        <name evidence="13" type="ORF">T28A8.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAB07286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T25392">
        <property type="entry name" value="T25392"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255207.1">
        <property type="nucleotide sequence ID" value="NM_001268278.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XU07"/>
    <dbReference type="SMR" id="Q9XU07"/>
    <dbReference type="DIP" id="DIP-26874N"/>
    <dbReference type="GeneID" id="189006"/>
    <dbReference type="UCSC" id="T28A8.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006691"/>
    <dbReference type="CTD" id="189006"/>
    <dbReference type="WormBase" id="T28A8.1a">
        <property type="protein sequence ID" value="CE18972"/>
        <property type="gene ID" value="WBGene00006691"/>
        <property type="gene designation" value="twk-40"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022504_0_0_1"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="PhylomeDB" id="Q9XU07"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006691">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XU07">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000258">
        <property type="entry name" value="TWiK family of potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF90">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="113"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="226"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB07286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="T28A8.1a"/>
        </source>
    </evidence>
    <sequence length="393" mass="45126" checksum="C02BE5EED022EBD8" modified="1999-11-01" version="1">MATWKTYARIILAHVSLIVLSVVYVGFGAFLFYQLEQPNEVEVRARNIERFNIHKRQMIEHLWEMRESGIGQHVVEDLAVKYVDNVTRILFEAFDTHCIGAKHLRPGGEDEDYNWTYMTALFFTTTLLTTIGYGNLTPVTGRGKLLCILYALFGVPLILITVADIGKFLSENIVQLYTWYRKLREKCSKQKYSVISSKDDKNKEGDLNLDHLENYISIPIFLIVAILLSYITFGAVVLSMWEGWDFFSGFYFSFITMTTVGFGDIVPLKREYYILDLCYIIIGLSITTMCIDLVGIQYIRKMHYFGRAIKDARFALVNVGGKMVHVPDLMRYASVLQQKYGQKKTHDTIIVKGAYAPKDLSKIRFIDFGALASIESWQSLWSILTGRTQEVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBK1</accession>
    <name>U4PBK1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">eel-1</name>
        <name evidence="16" type="ORF">CELE_Y67D8C.5</name>
        <name evidence="18" type="ORF">Y67D8C.5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
    </comment>
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        <text evidence="3">Protein modification; protein ubiquitination.</text>
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        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
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</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5004653476" evidence="1">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZC21.3c"/>
        </source>
    </evidence>
    <sequence length="242" mass="27448" checksum="D8FBB753489C774C" modified="2013-12-11" version="1">MMLRVLVFTSLVALSIAQLTSSCPSCNTNSNYDNTHQRYKRQQSYNSHQVPGFLPNTYQPDAFSSDSIRQETLRLNQAFFDSLTQTASPLSMQSSQSDPILTSQMDSQPIHIQTNAQSEPPYHHTFKNRPIPIVFADPEDTKHRDPTIFVEVHGDDSNTTTKSSPTLEFVQFTLEPPSADGTIYQATQGNEPSFFESEATRAIIEALTRDDPRYIQKDFRVEFMDPEETQLKHMEQNGYAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBL8</accession>
    <name>U4PBL8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">psr-1</name>
        <name evidence="14" type="ORF">CELE_F29B9.4</name>
        <name evidence="16" type="ORF">F29B9.4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the JMJD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294382.1">
        <property type="nucleotide sequence ID" value="NM_001307453.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBL8"/>
    <dbReference type="SMR" id="U4PBL8"/>
    <dbReference type="GeneID" id="177229"/>
    <dbReference type="AGR" id="WB:WBGene00004205"/>
    <dbReference type="CTD" id="177229"/>
    <dbReference type="WormBase" id="F29B9.4c">
        <property type="protein sequence ID" value="CE48597"/>
        <property type="gene ID" value="WBGene00004205"/>
        <property type="gene designation" value="psr-1"/>
    </dbReference>
    <dbReference type="OMA" id="NAWVAMR"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004205">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBL8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF32">
        <property type="entry name" value="BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="13">
        <location>
            <begin position="162"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="358"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDH93113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="F29B9.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBL8"/>
        </source>
    </evidence>
    <sequence length="416" mass="48546" checksum="EB2D9B341E9FDD33" modified="2013-12-11" version="1">MLSFATEFLDDMKRQLMSLGRDRYSLPRTYKRVSHAKDKARPELRKFGWETLGYSESFNLPPFRDSIQRVDGNNLTVEEFRRDFERPRIPVIITGLTDNWAAKDKWTVERLSKKYRNQNFKCGEDDNGNSVRMKMKYYHDYMLNNKDDSPLYIFDSSFAERRKTKKLSEDYSVPKFFEDDLFHYADDKKRPPHRWFVMGPARSGTAIHIDPLGTSAWNSLLQGHKRWVLIPPIAPRDLVKPMAHEKGKHPDEGITWFQTVYKRVRSPSWPKEYAPIECRQGPGETMFVPSGWWHVVINEEYTIAVTHNYCSVENLHLVWPKTVKGRPKLSKHWVKRLTEQRPELLEIIKSASEIPLYDMNESSSDSSSSSSSSDDSSDESDCDDSGRCGGRKRKNDDRSNECPEKMSTTYFQNSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBM5</accession>
    <name>U4PBM5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CELE_F52C12.6</name>
        <name evidence="11 13" type="ORF">F52C12.6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBM5"/>
    <dbReference type="SMR" id="U4PBM5"/>
    <dbReference type="PeptideAtlas" id="U4PBM5"/>
    <dbReference type="AGR" id="WB:WBGene00138717"/>
    <dbReference type="WormBase" id="F52C12.6b">
        <property type="protein sequence ID" value="CE48875"/>
        <property type="gene ID" value="WBGene00138717"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_0_0_1"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00138717">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBM5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001708">
        <property type="entry name" value="Protein kinase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDH93123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F52C12.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBM5"/>
        </source>
    </evidence>
    <sequence length="140" mass="15654" checksum="D0976309C3F8225D" modified="2013-12-11" version="1">MEFVPGSTAKNWISQLNPADFDAKTREFGQIFGEKLGKLHRGGLIHGDLTTSNIILRDDDLQKMTFIDFGLSSQGKVTPEEKGVDLYVLERAVISTHDKCAALIEGLMEGYKKADGKQFVAVEKKLNEIRLRGRKRDMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBM6</accession>
    <name>U4PBM6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">30S ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C09E9.1</name>
        <name evidence="2" type="ORF">CELE_C09E9.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360251.1">
        <property type="nucleotide sequence ID" value="NM_001372708.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBM6"/>
    <dbReference type="SMR" id="U4PBM6"/>
    <dbReference type="PeptideAtlas" id="U4PBM6"/>
    <dbReference type="GeneID" id="182452"/>
    <dbReference type="AGR" id="WB:WBGene00007476"/>
    <dbReference type="CTD" id="182452"/>
    <dbReference type="WormBase" id="C09E9.1d">
        <property type="protein sequence ID" value="CE48585"/>
        <property type="gene ID" value="WBGene00007476"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2851783_0_0_1"/>
    <dbReference type="OrthoDB" id="9025707at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007476">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBM6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C09E9.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBM6"/>
        </source>
    </evidence>
    <sequence length="65" mass="7395" checksum="A38A8948379E6113" modified="2013-12-11" version="1">MGLGSSKRKEEPPHKSEPKTVGRVKRAGARPDEMIAKYAEVLKTRGILPEYFLVHEAKRCRLSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBN0</accession>
    <name>U4PBN0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pac-1</name>
        <name evidence="6" type="ORF">C04D8.1</name>
        <name evidence="4" type="ORF">CELE_C04D8.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDH93128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293655.1">
        <property type="nucleotide sequence ID" value="NM_001306726.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBN0"/>
    <dbReference type="SMR" id="U4PBN0"/>
    <dbReference type="PeptideAtlas" id="U4PBN0"/>
    <dbReference type="GeneID" id="176201"/>
    <dbReference type="AGR" id="WB:WBGene00015418"/>
    <dbReference type="CTD" id="176201"/>
    <dbReference type="WormBase" id="C04D8.1e">
        <property type="protein sequence ID" value="CE49070"/>
        <property type="gene ID" value="WBGene00015418"/>
        <property type="gene designation" value="pac-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003398_0_0_1"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015418">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBN0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04395">
        <property type="entry name" value="RhoGAP_ARHGAP21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000058">
        <property type="entry name" value="GTPase-activating protein pac-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF133">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN PAC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="109"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDH93128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C04D8.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBN0"/>
        </source>
    </evidence>
    <sequence length="766" mass="83027" checksum="AD02B2186911ADBC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBN2</accession>
    <name>U4PBN2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">ddx-46</name>
        <name evidence="10" type="ORF">CELE_F53H1.1</name>
        <name evidence="12" type="ORF">F53H1.1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294487.1">
        <property type="nucleotide sequence ID" value="NM_001307558.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBN2"/>
    <dbReference type="SMR" id="U4PBN2"/>
    <dbReference type="PeptideAtlas" id="U4PBN2"/>
    <dbReference type="GeneID" id="176943"/>
    <dbReference type="AGR" id="WB:WBGene00018776"/>
    <dbReference type="CTD" id="176943"/>
    <dbReference type="WormBase" id="F53H1.1d">
        <property type="protein sequence ID" value="CE49055"/>
        <property type="gene ID" value="WBGene00018776"/>
        <property type="gene designation" value="ddx-46"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018776">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBN2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="261"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="403"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDH93274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F53H1.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBN2"/>
        </source>
    </evidence>
    <sequence length="610" mass="69958" checksum="E13FA8FFC253F0B2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBN3</accession>
    <name>U4PBN3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">fbxb-77</name>
        <name evidence="2" type="ORF">CELE_Y17G9B.7</name>
        <name evidence="4" type="ORF">Y17G9B.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294396.1">
        <property type="nucleotide sequence ID" value="NM_001307467.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBN3"/>
    <dbReference type="IntAct" id="U4PBN3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="189469"/>
    <dbReference type="KEGG" id="cel:CELE_Y17G9B.7"/>
    <dbReference type="AGR" id="WB:WBGene00021204"/>
    <dbReference type="CTD" id="189469"/>
    <dbReference type="WormBase" id="Y17G9B.7b">
        <property type="protein sequence ID" value="CE24186"/>
        <property type="gene ID" value="WBGene00021204"/>
        <property type="gene designation" value="fbxb-77"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028840_1_3_1"/>
    <dbReference type="OrthoDB" id="5909645at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021204">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBN3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012885">
        <property type="entry name" value="F-box_Sdz-33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053222">
        <property type="entry name" value="Zygotic_Embryogenesis-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22899">
        <property type="entry name" value="CYCLIN-RELATED F-BOX FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22899:SF0">
        <property type="entry name" value="F-BOX ASSOCIATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07735">
        <property type="entry name" value="FBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sdz-33 F-box" evidence="1">
        <location>
            <begin position="195"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y17G9B.7b"/>
        </source>
    </evidence>
    <sequence length="330" mass="38213" checksum="25022A4F2AB77BD5" modified="2013-12-11" version="1">MDDYVPIPFTLLKLPQKSIDVVLRRMCIEALVELSFTSKAAMQQTKHLGIKTERFIIAINSNEILIDVSGCRDFRFYTFECSTPSHHTVQKPIRVHVGFRGERWETPFFGVRQFLNHLMEIFHQTKLDSLHISTADPECSNELKGMEFGWLSMMSMTSDNNSSQDEDALRQFSGKTDSICLNRNPFSIEPSKQMQMILTRNMNVVSTKCDLNDVFVTNARSFTAFLKIEDVNIFLKHWMHRSDRKLKSAWFDLDAFRWDVEDVLEPLFKGIAYHVAPADREFIVHLPKKLSGCGDYRVIGGYDVRRNDGMTATIIVADRANVFLKMFFWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBN7</accession>
    <name>U4PBN7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphotransferase</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">hxk-3</name>
        <name evidence="4" type="ORF">CELE_Y77E11A.1</name>
        <name evidence="6" type="ORF">Y77E11A.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294488.1">
        <property type="nucleotide sequence ID" value="NM_001307559.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBN7"/>
    <dbReference type="SMR" id="U4PBN7"/>
    <dbReference type="PeptideAtlas" id="U4PBN7"/>
    <dbReference type="GeneID" id="176958"/>
    <dbReference type="KEGG" id="cel:CELE_Y77E11A.1"/>
    <dbReference type="AGR" id="WB:WBGene00022306"/>
    <dbReference type="CTD" id="176958"/>
    <dbReference type="WormBase" id="Y77E11A.1b">
        <property type="protein sequence ID" value="CE48834"/>
        <property type="gene ID" value="WBGene00022306"/>
        <property type="gene designation" value="hxk-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_3_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022306">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBN7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004396">
        <property type="term" value="F:hexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000016">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF32">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase C-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDH93279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y77E11A.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBN7"/>
        </source>
    </evidence>
    <sequence length="262" mass="28978" checksum="ACFBF660C9F5CA81" modified="2013-12-11" version="1">MNDTVGQLAAAAHKYGPECTIGVVIGYGCNSSYLEKTSRITKFDAKARGYDHDNMIVVTEWEEFGKHGELDDILTQFDREVDAASVHKGKQLIDKLCGALYIGEVVRRVLSQLVLDRVLFEGQSCEKLDEDESFPTKYISEILGEEEGVFKACRRICEELEVEMHGTGDYIIIREVCDVISRRGASIVAAAISALLRHLELSSVKIGVGGALIQFHPTYHQMLKEKLEELTPITMKFELVPADEGSCQGAALIAAVAERLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBN9</accession>
    <name>U4PBN9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">egrh-2</name>
        <name evidence="7" type="ORF">CELE_Y55F3AM.7</name>
        <name evidence="9" type="ORF">Y55F3AM.7</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368248.1">
        <property type="nucleotide sequence ID" value="NM_001380027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBN9"/>
    <dbReference type="SMR" id="U4PBN9"/>
    <dbReference type="GeneID" id="190308"/>
    <dbReference type="AGR" id="WB:WBGene00043705"/>
    <dbReference type="CTD" id="190308"/>
    <dbReference type="WormBase" id="Y55F3AM.7c">
        <property type="protein sequence ID" value="CE48849"/>
        <property type="gene ID" value="WBGene00043705"/>
        <property type="gene designation" value="egrh-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_42_18_1"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00043705">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBN9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004527">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000324">
        <property type="entry name" value="Early growth response protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000926">
        <property type="entry name" value="Kruppel like factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF60">
        <property type="entry name" value="STRIPE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDH93138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y55F3AM.7c"/>
        </source>
    </evidence>
    <sequence length="118" mass="14144" checksum="1633549F2343BED1" modified="2013-12-11" version="1">MKSSKMHLQDRPYKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICMRRFSRSDHLTTHVRTHTGEKPYSCDICGKKFARCDERTRHTKIHKKSQRSGSRQAQDEVWSSMEDPMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC02</accession>
    <name>U4PC02_CAEEL</name>
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        <recommendedName>
            <fullName evidence="2">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
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        <name evidence="5 7" type="ORF">Y67D8A.2</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC02"/>
    <dbReference type="SMR" id="U4PC02"/>
    <dbReference type="PeptideAtlas" id="U4PC02"/>
    <dbReference type="AGR" id="WB:WBGene00022059"/>
    <dbReference type="WormBase" id="Y67D8A.2e">
        <property type="protein sequence ID" value="CE48602"/>
        <property type="gene ID" value="WBGene00022059"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457285_0_0_1"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC02">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="4">
        <location>
            <begin position="335"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="541"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y67D8A.2e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="U4PC02"/>
        </source>
    </evidence>
    <sequence length="617" mass="70040" checksum="D49D846B855CC078" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC05</accession>
    <name>U4PC05_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">Nuclear receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">nhr-61</name>
        <name evidence="7" type="ORF">CELE_W01D2.2</name>
        <name evidence="9" type="ORF">W01D2.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293577.1">
        <property type="nucleotide sequence ID" value="NM_001306648.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC05"/>
    <dbReference type="SMR" id="U4PC05"/>
    <dbReference type="GeneID" id="175142"/>
    <dbReference type="AGR" id="WB:WBGene00003651"/>
    <dbReference type="CTD" id="175142"/>
    <dbReference type="WormBase" id="W01D2.2c">
        <property type="protein sequence ID" value="CE48530"/>
        <property type="gene ID" value="WBGene00003651"/>
        <property type="gene designation" value="nhr-61"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007368_3_3_1"/>
    <dbReference type="OrthoDB" id="5817395at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003651">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC05">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052499">
        <property type="entry name" value="C.elegans_NHRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630:SF2">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="6">
        <location>
            <begin position="50"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="157"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDH93275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="W01D2.2c"/>
        </source>
    </evidence>
    <sequence length="318" mass="36413" checksum="6F0997FF656E1624" modified="2013-12-11" version="1">MNPRAVQGDTVEDPEWDEEAMPETLSISTQTDALKVKKKSHTSLFTLDIKKEQIIDNLRAIYARTDPEEFWKLTYPGTYDFRYAFHNTKVVSPRTPLTPTAERIATLNDVVADFRRAFVLFVDILKSIDQLRDVQEDDKMKIAKSRFAAFYWWLCSTWSAKAGCNGVCYSNGSYHPASISDMPKSEGKHGVRIDYSGVSQKSLENLVEPLRRMELSDEERIVGAVMVILADPVPNVSTKTEKILAEARDFYLELLGYCIKLPEEQQGIRVSTMVLLLASIMELVHLTTDNIQLSDVLHVIDLGDWSQELRDHRYRRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC07</accession>
    <name>U4PC07_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_Y67D8A.2</name>
        <name evidence="5 7" type="ORF">Y67D8A.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC07"/>
    <dbReference type="SMR" id="U4PC07"/>
    <dbReference type="PeptideAtlas" id="U4PC07"/>
    <dbReference type="AGR" id="WB:WBGene00022059"/>
    <dbReference type="WormBase" id="Y67D8A.2j">
        <property type="protein sequence ID" value="CE48650"/>
        <property type="gene ID" value="WBGene00022059"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004177_0_1_1"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022059">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC07">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y67D8A.2j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="U4PC07"/>
        </source>
    </evidence>
    <sequence length="277" mass="30969" checksum="FC4B6BB80C8400FC" modified="2013-12-11" version="1">MTRTNWHLLSSLQTRRLNGALNRMPVNFYDRVWTILERSTHGIIIADQFLPQQPTLSDMTRFELTFSYKIEAMLSRISHPEYRQLLVELLSIIATILERNPEIAFTHSRIDCDSLIKKGFALFAAEEGIKDLNDLTPFYQLEGQALSTSTATFLTKAVVEFILAGRHFSQVINIFGEGTPEEKTLPSQHHRGKMPKIAYTGRASSEKKKRHVGGSSSSSQHHHHHQQQQTPLLRLATPLTPEPSSGTVTPRAITPSPLSSSLNTSGGGGQDESCRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC09</accession>
    <name>U4PC09_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">hxk-3</name>
        <name evidence="14" type="ORF">CELE_Y77E11A.1</name>
        <name evidence="16" type="ORF">Y77E11A.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294489.1">
        <property type="nucleotide sequence ID" value="NM_001307560.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC09"/>
    <dbReference type="SMR" id="U4PC09"/>
    <dbReference type="PeptideAtlas" id="U4PC09"/>
    <dbReference type="GeneID" id="176958"/>
    <dbReference type="AGR" id="WB:WBGene00022306"/>
    <dbReference type="CTD" id="176958"/>
    <dbReference type="WormBase" id="Y77E11A.1c">
        <property type="protein sequence ID" value="CE48815"/>
        <property type="gene ID" value="WBGene00022306"/>
        <property type="gene designation" value="hxk-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_3_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022306">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC09">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF32">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDH93280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="Y77E11A.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="U4PC09"/>
        </source>
    </evidence>
    <sequence length="208" mass="23158" checksum="9A089A7C16983F48" modified="2013-12-11" version="1">MIVVTEWEEFGKHGELDDILTQFDREVDAASVHKGKQLIDKLCGALYIGEVVRRVLSQLVLDRVLFEGQSCEKLDEDESFPTKYISEILGEEEGVFKACRRICEELEVEMHGTGDYIIIREVCDVISRRGASIVAAAISALLRHLELSSVKIGVGGALIQFHPTYHQMLKEKLEELTPITMKFELVPADEGSCQGAALIAAVAERLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>V6CJX3</accession>
    <name>V6CJX3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine Rich Secreted Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">grsp-3</name>
        <name evidence="4" type="ORF">C34D4.11</name>
        <name evidence="2" type="ORF">CELE_C34D4.11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368361.1">
        <property type="nucleotide sequence ID" value="NM_001380306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CJX3"/>
    <dbReference type="SMR" id="V6CJX3"/>
    <dbReference type="GeneID" id="183209"/>
    <dbReference type="KEGG" id="cel:CELE_C34D4.11"/>
    <dbReference type="AGR" id="WB:WBGene00016403"/>
    <dbReference type="CTD" id="183209"/>
    <dbReference type="WormBase" id="C34D4.11b">
        <property type="protein sequence ID" value="CE49207"/>
        <property type="gene ID" value="WBGene00016403"/>
        <property type="gene designation" value="grsp-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3052334_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016403">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CJX3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C34D4.11b"/>
        </source>
    </evidence>
    <sequence length="54" mass="6125" checksum="0F1DD3984E9E4293" modified="2014-02-19" version="1">MEEVETEEEDEEEEVEAVEDVVEEEAVEVEAEEEEAAEVEVEVDEAAEVVDVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>V6CJX7</accession>
    <name>V6CJX7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">hecd-1</name>
        <name evidence="16" type="ORF">C34D4.14</name>
        <name evidence="14" type="ORF">CELE_C34D4.14</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="10"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293691.1">
        <property type="nucleotide sequence ID" value="NM_001306762.2"/>
    </dbReference>
    <dbReference type="SMR" id="V6CJX7"/>
    <dbReference type="PeptideAtlas" id="V6CJX7"/>
    <dbReference type="GeneID" id="177486"/>
    <dbReference type="AGR" id="WB:WBGene00016405"/>
    <dbReference type="CTD" id="177486"/>
    <dbReference type="WormBase" id="C34D4.14d">
        <property type="protein sequence ID" value="CE49128"/>
        <property type="gene ID" value="WBGene00016405"/>
        <property type="gene designation" value="hecd-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412600at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016405">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CJX7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000320">
        <property type="entry name" value="E3 ubiquitin-protein ligase hecd-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000033">
        <property type="entry name" value="E3 ubiquitin-protein ligase hecd-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000051">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000033">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000007">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="13">
        <location>
            <begin position="1434"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="12">
        <location>
            <begin position="2236"/>
            <end position="2644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="433"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="645"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1372"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1534"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1571"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1648"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1807"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1379"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1539"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1571"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1606"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1649"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1663"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1732"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1752"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1808"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="2613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDK13342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="C34D4.14d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="V6CJX7"/>
        </source>
    </evidence>
    <sequence length="2644" mass="291768" checksum="BD8F0507D04846EE" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>V6CJZ4</accession>
    <name>V6CJZ4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">pif-1</name>
        <name evidence="1" type="ORF">CELE_Y18H1A.6</name>
        <name evidence="3" type="ORF">Y18H1A.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293175.1">
        <property type="nucleotide sequence ID" value="NM_001306246.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CJZ4"/>
    <dbReference type="SMR" id="V6CJZ4"/>
    <dbReference type="GeneID" id="171665"/>
    <dbReference type="AGR" id="WB:WBGene00004028"/>
    <dbReference type="CTD" id="171665"/>
    <dbReference type="WormBase" id="Y18H1A.6d">
        <property type="protein sequence ID" value="CE26961"/>
        <property type="gene ID" value="WBGene00004028"/>
        <property type="gene designation" value="pif-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_7_1_1"/>
    <dbReference type="OrthoDB" id="272985at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004028">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CJZ4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y18H1A.6d"/>
        </source>
    </evidence>
    <sequence length="80" mass="8851" checksum="D967EA5D7D009455" modified="2014-02-19" version="1">MTLDCAEISLERVFADGQAYVALSRARSLAAIRIIGFDASCVRANSKVIDFYKSIEAECDDEQDWEAPAAGPRLKRVRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>V6CJZ8</accession>
    <name>V6CJZ8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y18H1A.11</name>
        <name evidence="4 6" type="ORF">Y18H1A.11</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="2"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293180.1">
        <property type="nucleotide sequence ID" value="NM_001306251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CJZ8"/>
    <dbReference type="SMR" id="V6CJZ8"/>
    <dbReference type="GeneID" id="353380"/>
    <dbReference type="AGR" id="WB:WBGene00021215"/>
    <dbReference type="CTD" id="353380"/>
    <dbReference type="WormBase" id="Y18H1A.11d">
        <property type="protein sequence ID" value="CE49468"/>
        <property type="gene ID" value="WBGene00021215"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_1_1_1"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="UniPathway" id="UPA00753">
        <property type="reaction ID" value="UER00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021215">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CJZ8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF65">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDK13368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y18H1A.11d"/>
        </source>
    </evidence>
    <sequence length="138" mass="15923" checksum="6ADEEB139847BBED" modified="2014-02-19" version="1">MFHYGHANQFLQIKQTLPNVYLIVGVCSDEETMKNKGRTVQGEEERYEAIRHCRYVDEVYKASPWTCPIPFLKELKVDFMSHDALPYQGPAGEDIYEKHRTAGMFLETQRTEGISTSDSICRIIRDYDTPANIVCKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>V6CK94</accession>
    <name>V6CK94_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F41H10.3</name>
        <name evidence="2 4" type="ORF">F41H10.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CK94"/>
    <dbReference type="SMR" id="V6CK94"/>
    <dbReference type="PeptideAtlas" id="V6CK94"/>
    <dbReference type="AGR" id="WB:WBGene00018316"/>
    <dbReference type="WormBase" id="F41H10.3c">
        <property type="protein sequence ID" value="CE49202"/>
        <property type="gene ID" value="WBGene00018316"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874112at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018316">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CK94">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F41H10.3c"/>
        </source>
    </evidence>
    <sequence length="782" mass="86703" checksum="A8C8A4B943A62D1C" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>V6CK98</accession>
    <name>V6CK98_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein soc-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of Clr protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Suppressor of activated let-60 Ras protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">soc-2</name>
        <name evidence="13" type="ORF">AC7.2</name>
        <name evidence="11" type="ORF">CELE_AC7.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a scaffolding protein in a protein phosphatase complex that specifically dephosphorylates Raf kinase and stimulates Raf activity at specialized signaling complexes upon Ras activation. Required for vulval development. Involved in fluid homeostasis. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with let-60.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293759.1">
        <property type="nucleotide sequence ID" value="NM_001306830.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CK98"/>
    <dbReference type="SMR" id="V6CK98"/>
    <dbReference type="GeneID" id="177286"/>
    <dbReference type="AGR" id="WB:WBGene00004929"/>
    <dbReference type="CTD" id="177286"/>
    <dbReference type="WormBase" id="AC7.2d">
        <property type="protein sequence ID" value="CE49440"/>
        <property type="gene ID" value="WBGene00004929"/>
        <property type="gene designation" value="soc-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004929">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CK98">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000031">
        <property type="entry name" value="leucine-rich repeat protein SHOC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000281">
        <property type="entry name" value="Leucine-rich repeat protein soc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000969">
        <property type="entry name" value="Leucine-rich repeat protein soc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001085">
        <property type="entry name" value="Leucine-rich repeat protein soc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF167">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN SOC-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="382"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00079470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDK13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="AC7.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="V6CK98"/>
        </source>
    </evidence>
    <sequence length="549" mass="61676" checksum="3FAB0F9B60F06942" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL65</accession>
    <name>V6CL65_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dystrophin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">dys-1</name>
        <name evidence="7" type="ORF">CELE_F15D3.1</name>
        <name evidence="9" type="ORF">F15D3.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293158.1">
        <property type="nucleotide sequence ID" value="NM_001306229.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CL65"/>
    <dbReference type="SMR" id="V6CL65"/>
    <dbReference type="GeneID" id="173038"/>
    <dbReference type="AGR" id="WB:WBGene00001131"/>
    <dbReference type="CTD" id="173038"/>
    <dbReference type="WormBase" id="F15D3.1f">
        <property type="protein sequence ID" value="CE49342"/>
        <property type="gene ID" value="WBGene00001131"/>
        <property type="gene designation" value="dys-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000246_3_0_1"/>
    <dbReference type="OrthoDB" id="10057795at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001131">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CL65">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDK13325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F15D3.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="V6CL65"/>
        </source>
    </evidence>
    <sequence length="220" mass="24492" checksum="A8A53BBE256E9059" modified="2014-02-19" version="1">MDQMLHRLQFENKQLRKELEWKRGAASTMEIDRSSKRHQERHQSESRGGTLPLRNGRSVVSLKSTQSQNDVMDEAKALRLHKQRLEHRSRILEQQNEQLEMQLQRLKKVIDAQKQQAPLSTNSLLRGSHHQPWSPERARSGSASTLDRGLIVSSRHQEQAEAAGGGAEDSSDEAGGAGGGPRGSSVGQMQNLMTACDDLGKAMESLVVSVVYDSDDEEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL80</accession>
    <name>V6CL80_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">zen-4</name>
        <name evidence="9" type="ORF">CELE_M03D4.1</name>
        <name evidence="11" type="ORF">M03D4.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360296.1">
        <property type="nucleotide sequence ID" value="NM_001372837.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CL80"/>
    <dbReference type="SMR" id="V6CL80"/>
    <dbReference type="GeneID" id="177374"/>
    <dbReference type="AGR" id="WB:WBGene00006974"/>
    <dbReference type="CTD" id="177374"/>
    <dbReference type="WormBase" id="M03D4.1f">
        <property type="protein sequence ID" value="CE49182"/>
        <property type="gene ID" value="WBGene00006974"/>
        <property type="gene designation" value="zen-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2403182at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006974">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CL80">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4330">
        <property type="entry name" value="Kinesin-like protein Kif23, Arf6-interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032384">
        <property type="entry name" value="Kif23_Arf-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038105">
        <property type="entry name" value="Kif23_Arf-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF600">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16540">
        <property type="entry name" value="MKLP1_Arf_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="27"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="654"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="742"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDK13350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="M03D4.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="V6CL80"/>
        </source>
    </evidence>
    <sequence length="785" mass="88948" checksum="292411B17D1BA339" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL83</accession>
    <name>V6CL83_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C06E7.4</name>
        <name evidence="2" type="ORF">CELE_C06E7.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368356.1">
        <property type="nucleotide sequence ID" value="NM_001380246.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CL83"/>
    <dbReference type="GeneID" id="177356"/>
    <dbReference type="KEGG" id="cel:CELE_C06E7.4"/>
    <dbReference type="AGR" id="WB:WBGene00015541"/>
    <dbReference type="CTD" id="177356"/>
    <dbReference type="WormBase" id="C06E7.4b">
        <property type="protein sequence ID" value="CE03960"/>
        <property type="gene ID" value="WBGene00015541"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042452_0_0_1"/>
    <dbReference type="OrthoDB" id="5842445at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015541">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CL83">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C06E7.4b"/>
        </source>
    </evidence>
    <sequence length="335" mass="38492" checksum="C66343F020464955" modified="2014-02-19" version="1">MHEAPEIDVRMRQRDWRTSDERRGLPTRRETQSQYVKHNYSSTNRRAELNGSLASSSPMTSSEEGGHSSDPWNTSSISSGKRDIISPPMYSSTPHHHNHHNHQQLQHHQVIKSPQPPITKTIEVKVERSEKVEQQVSEPTKRAPPTAAQTASSTSSRIQHNQTLNNSNATYAQPIIRRQPSYGSRSSSIATSQMRCDQSEIDFSWVNEEEDKLKRESKRIDSLPEFYFGMDPPPVPSDNEKENDEKRNRRKSSVLEKTAAFEIEARRNDRKEPSFLSRSSHQLLTTSEIPPADYSPLSIHTKEIGGPAERRIYRIQKQQQQHSSEDRRYRSSIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL84</accession>
    <name>V6CL84_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C01B10.7</name>
        <name evidence="2" type="ORF">CELE_C01B10.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293704.1">
        <property type="nucleotide sequence ID" value="NM_001306775.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CL84"/>
    <dbReference type="GeneID" id="182060"/>
    <dbReference type="KEGG" id="cel:CELE_C01B10.7"/>
    <dbReference type="AGR" id="WB:WBGene00015281"/>
    <dbReference type="CTD" id="182060"/>
    <dbReference type="WormBase" id="C01B10.7b">
        <property type="protein sequence ID" value="CE49231"/>
        <property type="gene ID" value="WBGene00015281"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2962986_0_0_1"/>
    <dbReference type="OrthoDB" id="5835676at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015281">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CL84">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004744504" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C01B10.7b"/>
        </source>
    </evidence>
    <sequence length="59" mass="6787" checksum="5B59E9F899B00659" modified="2014-02-19" version="1">MVQVSTVLSLFLLLICLVDSSSEPKRTMIRKGVQWEKQDEMWILGECEDKEKSGTKNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL86</accession>
    <name>V6CL86_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pif-1</name>
        <name evidence="4" type="ORF">CELE_Y18H1A.6</name>
        <name evidence="6" type="ORF">Y18H1A.6</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293173.1">
        <property type="nucleotide sequence ID" value="NM_001306244.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CL86"/>
    <dbReference type="SMR" id="V6CL86"/>
    <dbReference type="GeneID" id="171665"/>
    <dbReference type="KEGG" id="cel:CELE_Y18H1A.6"/>
    <dbReference type="AGR" id="WB:WBGene00004028"/>
    <dbReference type="CTD" id="171665"/>
    <dbReference type="WormBase" id="Y18H1A.6b">
        <property type="protein sequence ID" value="CE49269"/>
        <property type="gene ID" value="WBGene00004028"/>
        <property type="gene designation" value="pif-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_7_1_1"/>
    <dbReference type="OrthoDB" id="272985at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004028">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CL86">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="218"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDK13361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y18H1A.6b"/>
        </source>
    </evidence>
    <sequence length="394" mass="44031" checksum="70017B882B0514C4" modified="2014-02-19" version="1">MLPAGNTYITAATGVAASQIGGITLHAFCGFRYENSTPEQCLKQVLRQNHMVRQWKQCSHLIIDEISMIDRDFFEALEYVARTVRNNDKPFGGIQLIITGDFFQLPPVSKDEPVFCFESEAWSRCIQKTIVLKNVKRQNDNVFVKILNNVRVGKCDFKSADILKESSKNQFPSSVIPTKLCTHSDDADRINSSSIETTQGDAKTFHAYDDESFDTHAKARTLAQKKLVLKVGAQVMLIKNIDVIKGLCNGSRGFVEKFSENGNPMIRFVSQADASIEIRRSKFSVRIPGSDAPLIRRQLPLQLAWAISIHKSQGMTLDCAEISLERVFADGQAYVALSRARSLAAIRIIGFDASCVRANSKVIDFYKSIEAECDDEQDWEAPAAGPRLKRVRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL91</accession>
    <name>V6CL91_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CELE_Y18H1A.11</name>
        <name evidence="11 13" type="ORF">Y18H1A.11</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CL91"/>
    <dbReference type="SMR" id="V6CL91"/>
    <dbReference type="AGR" id="WB:WBGene00021215"/>
    <dbReference type="WormBase" id="Y18H1A.11b">
        <property type="protein sequence ID" value="CE49274"/>
        <property type="gene ID" value="WBGene00021215"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="UniPathway" id="UPA00753">
        <property type="reaction ID" value="UER00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021215">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CL91">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF65">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="50"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDK13366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="Y18H1A.11b"/>
        </source>
    </evidence>
    <sequence length="194" mass="22107" checksum="F6A1BE68A21D387E" modified="2014-02-19" version="1">MCDDTLAFCSPAPFSDDVEVIKQREAIDYSTQITLEDAISGNVTRPVRVYADGVYDMFHYGHANQFLQIKQTLPNVYLIVGVCSDEETMKNKGRTVQGEEERYEAIRHCRYVDEVYKASPWTCPIPFLKELKVDFMSHDALPYQGPAGEDIYEKHRTAGMFLETQRTEGISTSDSICRIIRDYDTPANIVCKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL97</accession>
    <name>V6CL97_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y48G1C.8</name>
        <name evidence="3 5" type="ORF">Y48G1C.8</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293167.1">
        <property type="nucleotide sequence ID" value="NM_001306238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3564797"/>
    <dbReference type="KEGG" id="cel:CELE_Y48G1C.8"/>
    <dbReference type="AGR" id="WB:WBGene00021681"/>
    <dbReference type="CTD" id="3564797"/>
    <dbReference type="WormBase" id="Y48G1C.8a">
        <property type="protein sequence ID" value="CE49446"/>
        <property type="gene ID" value="WBGene00021681"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TFXA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254869_0_0_1"/>
    <dbReference type="OrthoDB" id="5786794at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021681">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CL97">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056649">
        <property type="entry name" value="DUF7747"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31824:SF2">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31824">
        <property type="entry name" value="PROTEIN CBG17809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24927">
        <property type="entry name" value="DUF7747"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7747" evidence="2">
        <location>
            <begin position="253"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7747" evidence="2">
        <location>
            <begin position="465"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7747" evidence="2">
        <location>
            <begin position="774"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7747" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y48G1C.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="V6CL97"/>
        </source>
    </evidence>
    <sequence length="1511" mass="171158" checksum="26AE8A2400F307FD" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL98</accession>
    <name>V6CL98_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock 70 kDa protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hsp-4</name>
        <name evidence="7" type="ORF">CELE_F43E2.8</name>
        <name evidence="9" type="ORF">F43E2.8</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDK13376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293470.1">
        <property type="nucleotide sequence ID" value="NM_001306541.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CL98"/>
    <dbReference type="SMR" id="V6CL98"/>
    <dbReference type="PeptideAtlas" id="V6CL98"/>
    <dbReference type="GeneID" id="174203"/>
    <dbReference type="KEGG" id="cel:CELE_F43E2.8"/>
    <dbReference type="AGR" id="WB:WBGene00002008"/>
    <dbReference type="CTD" id="174203"/>
    <dbReference type="WormBase" id="F43E2.8b">
        <property type="protein sequence ID" value="CE49318"/>
        <property type="gene ID" value="WBGene00002008"/>
        <property type="gene designation" value="hsp-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_3_0_1"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002008">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CL98">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDK13376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F43E2.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="V6CL98"/>
        </source>
    </evidence>
    <sequence length="324" mass="35299" checksum="5916D68F88D0BBD6" modified="2014-02-19" version="1">MDLFRATLKPVQKVLEDADMKKTDVHEIVLVGGSTRIPKVQQLIKDYFNGKEPSRGINPDEAVAYGAAVQAGVIGGVENTGDVVLLDVNPLTLGIETVGGVMTKLIGRNTVIPTKKSQVFSTAADSQSAVSIVIYEGERPMVMDNHKLGNFDVTGIPPAPRGVPQIEVTFEIDVNGILHVSAEDKGTGNKNKLTITNDHNRLSPEDIERMINDADKFAADDQAQKEKVESRNELEAYAYQMKTQIADKEKLGGKLTDEDKVSIESAVERAIEWLGSNQDASTEENKEQKKELESVVQPIVSKLYSAGGQGEQASEEPSEDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL99</accession>
    <name>V6CL99_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C06E7.2</name>
        <name evidence="2" type="ORF">CELE_C06E7.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368355.1">
        <property type="nucleotide sequence ID" value="NM_001380245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CL99"/>
    <dbReference type="SMR" id="V6CL99"/>
    <dbReference type="GeneID" id="177353"/>
    <dbReference type="KEGG" id="cel:CELE_C06E7.2"/>
    <dbReference type="AGR" id="WB:WBGene00015539"/>
    <dbReference type="CTD" id="177353"/>
    <dbReference type="WormBase" id="C06E7.2b">
        <property type="protein sequence ID" value="CE49333"/>
        <property type="gene ID" value="WBGene00015539"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510227_0_0_1"/>
    <dbReference type="OrthoDB" id="5873999at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015539">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CL99">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C06E7.2b"/>
        </source>
    </evidence>
    <sequence length="223" mass="24432" checksum="6CE3477ED2499C43" modified="2014-02-19" version="1">MLSASHPEHVTCISATSFSFDVGIIRESTVEKLKVDPRPPFGTKVSSRPSSKASKLNEQFNQKHKASTPSPTKKPSESSVTPSSATSFKPKEAYSPSKSFFSYEMGGVGTTSASEINEKILISNEIPVDEISKEEEEKAEKELNEIIKELKSDEEAVDGEKDVGELKTREVNMTSENGEENSENSHSNDTSTDAKAVKSSKTTMNSNFILISISSILFCKYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MAQ8</accession>
    <name>A0A131MAQ8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Histone acetyltransferase</fullName>
            <ecNumber evidence="2 8">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">mys-2</name>
        <name evidence="11" type="ORF">CELE_K03D10.3</name>
        <name evidence="13" type="ORF">K03D10.3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 8"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CZR14445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317768.1">
        <property type="nucleotide sequence ID" value="NM_001330941.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MAQ8"/>
    <dbReference type="SMR" id="A0A131MAQ8"/>
    <dbReference type="GeneID" id="173281"/>
    <dbReference type="AGR" id="WB:WBGene00010537"/>
    <dbReference type="CTD" id="173281"/>
    <dbReference type="WormBase" id="K03D10.3b">
        <property type="protein sequence ID" value="CE51534"/>
        <property type="gene ID" value="WBGene00010537"/>
        <property type="gene designation" value="mys-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010537">
        <property type="expression patterns" value="Expressed in embryo and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MAQ8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000932">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000013">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000094">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF82">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="10">
        <location>
            <begin position="184"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="463"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CZR14445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="K03D10.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MAQ8"/>
        </source>
    </evidence>
    <sequence length="517" mass="60365" checksum="61186CB665450CEC" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MAS8</accession>
    <name>A0A131MAS8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M13 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nep-8</name>
        <name evidence="2" type="ORF">CELE_F18A12.4</name>
        <name evidence="4" type="ORF">F18A12.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309551.1">
        <property type="nucleotide sequence ID" value="NM_001322724.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MAS8"/>
    <dbReference type="SMR" id="A0A131MAS8"/>
    <dbReference type="GeneID" id="184631"/>
    <dbReference type="AGR" id="WB:WBGene00017553"/>
    <dbReference type="CTD" id="184631"/>
    <dbReference type="WormBase" id="F18A12.4d">
        <property type="protein sequence ID" value="CE51486"/>
        <property type="gene ID" value="WBGene00017553"/>
        <property type="gene designation" value="nep-8"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873741at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017553">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MAS8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF7">
        <property type="entry name" value="NEPRILYSIN METALLOPEPTIDASE FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="266"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F18A12.4d"/>
        </source>
    </evidence>
    <sequence length="464" mass="52873" checksum="35510AC46EA7490D" modified="2016-05-11" version="1">MLSNLVKLGATNLGLFQLDFRILTEGKFVRIAPTLGSIVHNSTMISMISEILEANGVQPDSEEISKEFEEYSSLQMKLAKYQSSGKLSISLPGVRSINFSSLITEMIHPSRVSKIFGKIRVVTSEHPLFFKSNETESDVRREFPRASLRVFMRNFVDKGNRDGVKKLTEELKKNTLEMIQDTENLAPPVKESMLKKVEAIKVTIGYPDHFDPPGTLDKEFENFDLDSTDSYYRIFQKLNRLRSEQQMEFIAGETPISPIKEVLKVNANYKRSKNALTVFAPFLDDPFFDITYPDYVNLFFSGFLIAHEIGHSVDANGLGYDENGKPMDGIRLEHVTEYGKQGQCLVDQYDNYDDPVYGKKMNGTHSINEIIADWVGHEVTWRAYKKMDTSKMLSLIGLKDINMDQLYFRVQSLLFCRERDTISLEETLKDVYPTDNFRVNGAYARVCGGVQLSGYITYESGEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MAW0</accession>
    <name>A0A131MAW0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cutl-12</name>
        <name evidence="3" type="ORF">CELE_T22C8.7</name>
        <name evidence="5" type="ORF">T22C8.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309580.1">
        <property type="nucleotide sequence ID" value="NM_001322751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MAW0"/>
    <dbReference type="SMR" id="A0A131MAW0"/>
    <dbReference type="GeneID" id="188735"/>
    <dbReference type="AGR" id="WB:WBGene00011928"/>
    <dbReference type="CTD" id="188735"/>
    <dbReference type="WormBase" id="T22C8.7c">
        <property type="protein sequence ID" value="CE51437"/>
        <property type="gene ID" value="WBGene00011928"/>
        <property type="gene designation" value="cutl-12"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011928">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MAW0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CZR14496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T22C8.7c"/>
        </source>
    </evidence>
    <sequence length="124" mass="14177" checksum="8C0D21D77F8B3F5E" modified="2016-05-11" version="1">MDSELEPLPYPTKASVYQHRSPRSHKRVLEDANITLEVETTKIMILENEPSAEKFRLGEAREQSGPEPMKCTTSENYVSNTLLLTTLGVLQVISILALITQRFYYKKSIDNLIYADDRPGSRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MAX2</accession>
    <name>A0A131MAX2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">wht-3</name>
        <name evidence="11" type="ORF">C16C10.12</name>
        <name evidence="9" type="ORF">CELE_C16C10.12</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CZR14509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309589.1">
        <property type="nucleotide sequence ID" value="NM_001322779.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MAX2"/>
    <dbReference type="SMR" id="A0A131MAX2"/>
    <dbReference type="GeneID" id="175528"/>
    <dbReference type="AGR" id="WB:WBGene00007631"/>
    <dbReference type="CTD" id="175528"/>
    <dbReference type="WormBase" id="C16C10.12b">
        <property type="protein sequence ID" value="CE51443"/>
        <property type="gene ID" value="WBGene00007631"/>
        <property type="gene designation" value="wht-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007631">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MAX2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF31">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE WHT-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="18"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CZR14509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C16C10.12b"/>
        </source>
    </evidence>
    <sequence length="600" mass="68225" checksum="BED64278B603FACC" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MAX6</accession>
    <name>A0A131MAX6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">nep-8</name>
        <name evidence="10" type="ORF">CELE_F18A12.4</name>
        <name evidence="12" type="ORF">F18A12.4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309550.1">
        <property type="nucleotide sequence ID" value="NM_001322723.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MAX6"/>
    <dbReference type="SMR" id="A0A131MAX6"/>
    <dbReference type="GeneID" id="184631"/>
    <dbReference type="AGR" id="WB:WBGene00017553"/>
    <dbReference type="CTD" id="184631"/>
    <dbReference type="WormBase" id="F18A12.4c">
        <property type="protein sequence ID" value="CE51264"/>
        <property type="gene ID" value="WBGene00017553"/>
        <property type="gene designation" value="nep-8"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873741at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017553">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MAX6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF7">
        <property type="entry name" value="NEPRILYSIN METALLOPEPTIDASE FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="48"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="305"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CZR14465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F18A12.4c"/>
        </source>
    </evidence>
    <sequence length="503" mass="57297" checksum="9F321D19714D7784" modified="2016-05-11" version="1">MLSNLVKLGATNLGLFQLDFRILTEGKFVRIAPTLGSIVHNSTMISMISEILEANGVQPDSEEISKEFEEYSSLQMKLAKYQSSGKLSISLPGVRSINFSSLITEMIHPSRVSKIFGKIRVVTSEHPLFFKSNETESLDTIIESTSNKTLANFLIFNYIQSSYNIMKGARRGNCEDDVRREFPRASLRVFMRNFVDKGNRDGVKKLTEELKKNTLEMIQDTENLAPPVKESMLKKVEAIKVTIGYPDHFDPPGTLDKEFENFDLDSTDSYYRIFQKLNRLRSEQQMEFIAGETPISPIKEVLKVNANYKRSKNALTVFAPFLDDPFFDITYPDYVNLFFSGFLIAHEIGHSVDANGLGYDENGKPMDGIRLEHVTEYGKQGQCLVDQYDNYDDPVYGKKMNGTHSINEIIADWVGHEVTWRAYKKMDTSKMLSLIGLKDINMDQLYFRVQSLLFCRERDTISLEETLKDVYPTDNFRVNGAYARVCGGVQLSGYITYESGEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB23</accession>
    <name>A0A131MB23_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cah-1</name>
        <name evidence="3" type="ORF">CELE_F54D8.4</name>
        <name evidence="5" type="ORF">F54D8.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CZR14518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309597.1">
        <property type="nucleotide sequence ID" value="NM_001322587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB23"/>
    <dbReference type="SMR" id="A0A131MB23"/>
    <dbReference type="GeneID" id="186231"/>
    <dbReference type="AGR" id="WB:WBGene00000279"/>
    <dbReference type="CTD" id="186231"/>
    <dbReference type="WormBase" id="F54D8.4b">
        <property type="protein sequence ID" value="CE51393"/>
        <property type="gene ID" value="WBGene00000279"/>
        <property type="gene designation" value="cah-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5978072at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000279">
        <property type="expression patterns" value="Expressed in anatomical system and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MB23">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF258">
        <property type="entry name" value="CARBONIC ANHYDRASE-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CZR14518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F54D8.4b"/>
        </source>
    </evidence>
    <sequence length="209" mass="24186" checksum="7FEA0D48CB5E86A8" modified="2016-05-11" version="1">MVRVRIGYSSKKPSVNITSGPLYGYRYRVQRIDFHMGRKNENGSEHTINGRRFPMEVQLVAYNTDLYPNFTSASKSPHGIAILSVLVDFGPETNQELIKLTIATASISYKDQRVQLADFEPWRLLPFTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMEGAEKVPVAPNFRKIQETNNRLVRTNIQHKVWIFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB32</accession>
    <name>A0A131MB32_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle collagen 99</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">col-99</name>
        <name evidence="4" type="ORF">CELE_F29C4.8</name>
        <name evidence="6" type="ORF">F29C4.8</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CZR14528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309607.1">
        <property type="nucleotide sequence ID" value="NM_001322769.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB32"/>
    <dbReference type="GeneID" id="185112"/>
    <dbReference type="AGR" id="WB:WBGene00000674"/>
    <dbReference type="CTD" id="185112"/>
    <dbReference type="WormBase" id="F29C4.8l">
        <property type="protein sequence ID" value="CE51515"/>
        <property type="gene ID" value="WBGene00000674"/>
        <property type="gene designation" value="col-99"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8964326at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000674">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MB32">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="662"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CZR14528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F29C4.8l"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MB32"/>
        </source>
    </evidence>
    <sequence length="711" mass="71615" checksum="76CA6E30C83C33A1" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB33</accession>
    <name>A0A131MB33_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">che-7</name>
        <name evidence="12" type="synonym">inx</name>
        <name evidence="14" type="ORF">CELE_F26D11.10</name>
        <name evidence="16" type="ORF">F26D11.10</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309634.1">
        <property type="nucleotide sequence ID" value="NM_001322572.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB33"/>
    <dbReference type="SMR" id="A0A131MB33"/>
    <dbReference type="PaxDb" id="6239-F26D11.10"/>
    <dbReference type="GeneID" id="184979"/>
    <dbReference type="KEGG" id="cel:CELE_F26D11.10"/>
    <dbReference type="AGR" id="WB:WBGene00000488"/>
    <dbReference type="CTD" id="184979"/>
    <dbReference type="WormBase" id="F26D11.10c">
        <property type="protein sequence ID" value="CE51364"/>
        <property type="gene ID" value="WBGene00000488"/>
        <property type="gene designation" value="che-7"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RB1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000488">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MB33">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF19">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="445"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CZR14559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="F26D11.10c"/>
        </source>
    </evidence>
    <sequence length="556" mass="64843" checksum="7F6979C73DEED5C6" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB43</accession>
    <name>A0A131MB43_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F40C5.1</name>
        <name evidence="1 3" type="ORF">F40C5.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309644.1">
        <property type="nucleotide sequence ID" value="NM_001322537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB43"/>
    <dbReference type="GeneID" id="185514"/>
    <dbReference type="KEGG" id="cel:CELE_F40C5.1"/>
    <dbReference type="AGR" id="WB:WBGene00018228"/>
    <dbReference type="CTD" id="185514"/>
    <dbReference type="WormBase" id="F40C5.1b">
        <property type="protein sequence ID" value="CE51334"/>
        <property type="gene ID" value="WBGene00018228"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408912at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
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        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03567">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CZR14569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F40C5.1b"/>
        </source>
    </evidence>
    <sequence length="104" mass="12101" checksum="111C100EB0A8D6E5" modified="2016-05-11" version="1">MGSDTEERVSSAARLADILRKQGVRGSLVEKIHKNILTAETAHSTHKSSNRYEAERQVREDPFVRGYLHKIYLFDYLVFPFDRRVLDTAYQKIDSKLFLEEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB81</accession>
    <name>A0A131MB81_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srj-9</name>
        <name evidence="2" type="ORF">CELE_T20C4.1</name>
        <name evidence="4" type="ORF">T20C4.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309653.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB81"/>
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    <dbReference type="AGR" id="WB:WBGene00005597"/>
    <dbReference type="CTD" id="191934"/>
    <dbReference type="WormBase" id="T20C4.1d">
        <property type="protein sequence ID" value="CE51405"/>
        <property type="gene ID" value="WBGene00005597"/>
        <property type="gene designation" value="srj-9"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5790586at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005597">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MB81">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019423">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srj"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45907">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45907:SF15">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10319">
        <property type="entry name" value="7TM_GPCR_Srj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T20C4.1d"/>
        </source>
    </evidence>
    <sequence length="250" mass="28659" checksum="487D412C9B4B15A5" modified="2016-05-11" version="1">MSNRCGFISLSYALLIIHFVYRYMALFHADKLPIFFQPLGIIISIIFLLMHAASWSVICQQCLAGNEEVREIISIDFLENFGANSKSLPMLAAIYYDASDYIRFRSWLGIFLLTAFSFYAMSVYIILGFKIMRKITLMQSTNKLSKNSIRLQKQLFQTLIIQTCIPIIGSFLPTVISWYAPIFGVNMEWWNMNVATVAMAAFPFIDPLAVIYLIPSYRNAILRKRGNIVDDSSHVKTRQSSRMQSYAFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB92</accession>
    <name>A0A131MB92_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="6">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">acs-22</name>
        <name evidence="13" type="ORF">CELE_D1009.1</name>
        <name evidence="15" type="ORF">D1009.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CZR14610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309684.1">
        <property type="nucleotide sequence ID" value="NM_001322629.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB92"/>
    <dbReference type="SMR" id="A0A131MB92"/>
    <dbReference type="GeneID" id="181138"/>
    <dbReference type="KEGG" id="cel:CELE_D1009.1"/>
    <dbReference type="AGR" id="WB:WBGene00017012"/>
    <dbReference type="CTD" id="181138"/>
    <dbReference type="WormBase" id="D1009.1d">
        <property type="protein sequence ID" value="CE51246"/>
        <property type="gene ID" value="WBGene00017012"/>
        <property type="gene designation" value="acs-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017012">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MB92">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="11">
        <location>
            <begin position="2"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="12">
        <location>
            <begin position="397"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CZR14610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="D1009.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MB92"/>
        </source>
    </evidence>
    <sequence length="525" mass="58458" checksum="4902FC023CF8B76A" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB93</accession>
    <name>A0A131MB93_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Seven TM Receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">str-260</name>
        <name evidence="2" type="ORF">CELE_T24A6.6</name>
        <name evidence="4" type="ORF">T24A6.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309663.1">
        <property type="nucleotide sequence ID" value="NM_001322528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB93"/>
    <dbReference type="GeneID" id="192046"/>
    <dbReference type="KEGG" id="cel:CELE_T24A6.6"/>
    <dbReference type="AGR" id="WB:WBGene00006286"/>
    <dbReference type="CTD" id="192046"/>
    <dbReference type="WormBase" id="T24A6.6b">
        <property type="protein sequence ID" value="CE51463"/>
        <property type="gene ID" value="WBGene00006286"/>
        <property type="gene designation" value="str-260"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859535at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MB93">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF6">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T24A6.6b"/>
        </source>
    </evidence>
    <sequence length="264" mass="30086" checksum="5957945C80497346" modified="2016-05-11" version="1">MACCSVLFYGGFYGITLAILALHFIYRFLSITNNRHLNSFNSWKIILWFMGPPISGIIFMLTGAFIMSSNGDSDRFLSENYPTLLGNETKIEDLYYVGPFFWPKYNNFTTDQYFNWRTAGGAMIVMGLISLSIAIMVYFGVKGYRSMNKLIAQSNSSQKFRSVQKQLFNALVLQTFIPVLLMHIPASAIYFTIFFDKCTEYLGKIFTLTVAMYPTFNPLPTIFIVKNYRNALKDSLICVEDAVLRRSRTVHPSSTAYSVNTQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H9S8</accession>
    <name>A0A168H9S8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl-hydrolase family 116 catalytic region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_R08F11.1</name>
        <name evidence="2 4" type="ORF">R08F11.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317833.1">
        <property type="nucleotide sequence ID" value="NM_001330811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H9S8"/>
    <dbReference type="SMR" id="A0A168H9S8"/>
    <dbReference type="GeneID" id="187703"/>
    <dbReference type="AGR" id="WB:WBGene00019965"/>
    <dbReference type="CTD" id="187703"/>
    <dbReference type="WormBase" id="R08F11.1b">
        <property type="protein sequence ID" value="CE51583"/>
        <property type="gene ID" value="WBGene00019965"/>
    </dbReference>
    <dbReference type="OrthoDB" id="730489at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019965">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A168H9S8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000141">
        <property type="entry name" value="Non-lysosomal glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052566">
        <property type="entry name" value="Non-lysos_glucosylceramidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654">
        <property type="entry name" value="BILE ACID BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654:SF0">
        <property type="entry name" value="NON-LYSOSOMAL GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl-hydrolase family 116 catalytic region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SAP35595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R08F11.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A168H9S8"/>
        </source>
    </evidence>
    <sequence length="329" mass="37694" checksum="BA8CB161551B16BF" modified="2016-07-06" version="1">MDRVDNNIATSLADGEQMTIKSVDRIPHDMGHPMADPWIHTNAYILHDTGRWKDLNLKFVISCYRDWKLIELGSEKGQVLEFFLGKCTKIVDGALECWDKDNDGMIENDGFADQTYDVWKMTGTSAYCGSLWIAALSSYIEMLKQSGLPTKHYEEKLEMAYDAYIGKLWNGTFFKFDELPENSKIVMADQLCGFWAMTAMDEPVQISKDKMKSALDTIFKYNVQMYNNGRCGAVNGYLTSERVDGSSIQSEEVWAGITYALSAMMIEKGMDEQAFKTSEGLFESIWHRFPLQYQTPEAITSDGMYRALGYMRPLSIWAIQHALDRRYRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-01-31" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSL9-2</accession>
    <name>AJM1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform 2 of Apical junction molecule ajm-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">jam-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ajm-1</name>
        <name evidence="3" type="ORF">C25A11.4</name>
        <name type="ORF">CELE_C25A11.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nat. Cell Biol." volume="3" first="983" last="991">
            <title>Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia.</title>
            <authorList>
                <person name="Koeppen M."/>
                <person name="Simske J.S."/>
                <person name="Sims P.A."/>
                <person name="Firestein B.L."/>
                <person name="Hall D.H."/>
                <person name="Radice A.D."/>
                <person name="Rongo C."/>
                <person name="Hardin J.D."/>
            </authorList>
            <dbReference type="PubMed" id="11715019"/>
            <dbReference type="DOI" id="10.1038/ncb1101-983"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INTERACTION WITH DLG-1</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="J. Cell Sci." volume="121" first="1477" last="1487">
            <title>Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.</title>
            <authorList>
                <person name="Lockwood C.A."/>
                <person name="Lynch A.M."/>
                <person name="Hardin J."/>
            </authorList>
            <dbReference type="PubMed" id="18411252"/>
            <dbReference type="DOI" id="10.1242/jcs.017137"/>
        </citation>
        <scope>INTERACTION WITH DLG-1</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="Dev. Cell" volume="38" first="493" last="506">
            <title>A Conserved role for girdin in basal body positioning and ciliogenesis.</title>
            <authorList>
                <person name="Nechipurenko I.V."/>
                <person name="Olivier-Mason A."/>
                <person name="Kazatskaya A."/>
                <person name="Kennedy J."/>
                <person name="McLachlan I.G."/>
                <person name="Heiman M.G."/>
                <person name="Blacque O.E."/>
                <person name="Sengupta P."/>
            </authorList>
            <dbReference type="PubMed" id="27623382"/>
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                <person name="Sims P.A."/>
                <person name="Firestein B.L."/>
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                <person name="McLachlan I.G."/>
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                <person name="Sims P.A."/>
                <person name="Firestein B.L."/>
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                <person name="Olivier-Mason A."/>
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                <person name="McLachlan I.G."/>
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                <person name="Simske J.S."/>
                <person name="Sims P.A."/>
                <person name="Firestein B.L."/>
                <person name="Hall D.H."/>
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                <person name="Olivier-Mason A."/>
                <person name="Kazatskaya A."/>
                <person name="Kennedy J."/>
                <person name="McLachlan I.G."/>
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        <citation type="journal article" date="2001" name="Nat. Cell Biol." volume="3" first="983" last="991">
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                <person name="Simske J.S."/>
                <person name="Sims P.A."/>
                <person name="Firestein B.L."/>
                <person name="Hall D.H."/>
                <person name="Radice A.D."/>
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                <person name="Lynch A.M."/>
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            <dbReference type="DOI" id="10.1242/jcs.017137"/>
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        <citation type="journal article" date="2016" name="Dev. Cell" volume="38" first="493" last="506">
            <title>A Conserved role for girdin in basal body positioning and ciliogenesis.</title>
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                <person name="Nechipurenko I.V."/>
                <person name="Olivier-Mason A."/>
                <person name="Kazatskaya A."/>
                <person name="Kennedy J."/>
                <person name="McLachlan I.G."/>
                <person name="Heiman M.G."/>
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        <citation type="journal article" date="2001" name="Nat. Cell Biol." volume="3" first="983" last="991">
            <title>Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia.</title>
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                <person name="Simske J.S."/>
                <person name="Sims P.A."/>
                <person name="Firestein B.L."/>
                <person name="Hall D.H."/>
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        <citation type="journal article" date="2008" name="J. Cell Sci." volume="121" first="1477" last="1487">
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                <person name="Lynch A.M."/>
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        <citation type="journal article" date="2016" name="Dev. Cell" volume="38" first="493" last="506">
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                <person name="Olivier-Mason A."/>
                <person name="Kazatskaya A."/>
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                <person name="McLachlan I.G."/>
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        <citation type="journal article" date="2001" name="Nat. Cell Biol." volume="3" first="983" last="991">
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                <person name="Simske J.S."/>
                <person name="Sims P.A."/>
                <person name="Firestein B.L."/>
                <person name="Hall D.H."/>
                <person name="Radice A.D."/>
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        <scope>TISSUE SPECIFICITY</scope>
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        <scope>DEVELOPMENTAL STAGE</scope>
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        <citation type="journal article" date="2008" name="J. Cell Sci." volume="121" first="1477" last="1487">
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                <person name="Lynch A.M."/>
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            <dbReference type="DOI" id="10.1242/jcs.017137"/>
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        <citation type="journal article" date="2016" name="Dev. Cell" volume="38" first="493" last="506">
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                <person name="Olivier-Mason A."/>
                <person name="Kazatskaya A."/>
                <person name="Kennedy J."/>
                <person name="McLachlan I.G."/>
                <person name="Heiman M.G."/>
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        </isoform>
        <isoform>
            <id>A0A1C3NSL9-11</id>
            <name>11</name>
            <sequence type="described" ref="VSP_059287"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-3</id>
            <name>3</name>
            <sequence type="described" ref="VSP_059286"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-10</id>
            <name>10</name>
            <sequence type="described" ref="VSP_059289"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-6</id>
            <name>6</name>
            <sequence type="described" ref="VSP_059293"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367383.1">
        <property type="nucleotide sequence ID" value="NM_001381046.2"/>
    </dbReference>
    <dbReference type="WormBase" id="C25A11.4d">
        <property type="protein sequence ID" value="CE51720"/>
        <property type="gene ID" value="WBGene00000100"/>
        <property type="gene designation" value="ajm-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C25A11.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C25A11.4k"/>
        </source>
    </evidence>
    <sequence length="1864" mass="217081" checksum="8CC51B98B43FB6E0" modified="2016-11-02" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-01-31" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSL9-9</accession>
    <name>AJM1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform 9 of Apical junction molecule ajm-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">jam-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ajm-1</name>
        <name evidence="3" type="ORF">C25A11.4</name>
        <name type="ORF">CELE_C25A11.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nat. Cell Biol." volume="3" first="983" last="991">
            <title>Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia.</title>
            <authorList>
                <person name="Koeppen M."/>
                <person name="Simske J.S."/>
                <person name="Sims P.A."/>
                <person name="Firestein B.L."/>
                <person name="Hall D.H."/>
                <person name="Radice A.D."/>
                <person name="Rongo C."/>
                <person name="Hardin J.D."/>
            </authorList>
            <dbReference type="PubMed" id="11715019"/>
            <dbReference type="DOI" id="10.1038/ncb1101-983"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INTERACTION WITH DLG-1</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="J. Cell Sci." volume="121" first="1477" last="1487">
            <title>Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.</title>
            <authorList>
                <person name="Lockwood C.A."/>
                <person name="Lynch A.M."/>
                <person name="Hardin J."/>
            </authorList>
            <dbReference type="PubMed" id="18411252"/>
            <dbReference type="DOI" id="10.1242/jcs.017137"/>
        </citation>
        <scope>INTERACTION WITH DLG-1</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="Dev. Cell" volume="38" first="493" last="506">
            <title>A Conserved role for girdin in basal body positioning and ciliogenesis.</title>
            <authorList>
                <person name="Nechipurenko I.V."/>
                <person name="Olivier-Mason A."/>
                <person name="Kazatskaya A."/>
                <person name="Kennedy J."/>
                <person name="McLachlan I.G."/>
                <person name="Heiman M.G."/>
                <person name="Blacque O.E."/>
                <person name="Sengupta P."/>
            </authorList>
            <dbReference type="PubMed" id="27623382"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2016.07.013"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A1C3NSL9-10</id>
            <name>10</name>
            <sequence type="described" ref="VSP_059289"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-2</id>
            <name>2</name>
            <sequence type="described" ref="VSP_059285"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-6</id>
            <name>6</name>
            <sequence type="described" ref="VSP_059293"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-11</id>
            <name>11</name>
            <sequence type="described" ref="VSP_059287"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-8</id>
            <name>8</name>
            <sequence type="described" ref="VSP_059293 VSP_059294"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-5</id>
            <name>5</name>
            <sequence type="described" ref="VSP_059292"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-3</id>
            <name>3</name>
            <sequence type="described" ref="VSP_059286"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-7</id>
            <name>7</name>
            <sequence type="described" ref="VSP_059288"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-4</id>
            <name>4</name>
            <sequence type="described" ref="VSP_059291"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-9</id>
            <name>9</name>
            <sequence type="described" ref="VSP_059290"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001317888.1">
        <property type="nucleotide sequence ID" value="NM_001330911.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C25A11.4g">
        <property type="protein sequence ID" value="CE51727"/>
        <property type="gene ID" value="WBGene00000100"/>
        <property type="gene designation" value="ajm-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C25A11.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C25A11.4k"/>
        </source>
    </evidence>
    <sequence length="1487" mass="176098" checksum="26C4CFA0FA10CCF1" modified="2016-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DQF4</accession>
    <name>A0A3B1DQF4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Steroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">stdh-4</name>
        <name evidence="8" type="ORF">CELE_F25G6.5</name>
        <name evidence="10" type="ORF">F25G6.5</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="VAY52524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355440.1">
        <property type="nucleotide sequence ID" value="NM_001368458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1DQF4"/>
    <dbReference type="SMR" id="A0A3B1DQF4"/>
    <dbReference type="GeneID" id="184934"/>
    <dbReference type="AGR" id="WB:WBGene00006435"/>
    <dbReference type="CTD" id="184934"/>
    <dbReference type="WormBase" id="F25G6.5b">
        <property type="protein sequence ID" value="CE52769"/>
        <property type="gene ID" value="WBGene00006435"/>
        <property type="gene designation" value="stdh-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006435">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1DQF4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000467">
        <property type="entry name" value="Steroid dehydrogenase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF1">
        <property type="entry name" value="STEROID DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VAY52524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F25G6.5b"/>
        </source>
    </evidence>
    <sequence length="317" mass="35790" checksum="3E8A2ECE13EB1678" modified="2018-12-05" version="1">MYFSLNLDENLLIMIIVIAYTLQFLYHLIKISLNIFGVYIFYTPIDLKRTAGASWAVVTGATDGIGRSYALDLARRGFNIFLISRTKSKLVKTKKQILNKYSDIEVRYAICDFTRVSYEDYKRLLHSLNEVDIGILINNVGMCFDNPEVLHRVEGGIDTLTNVINVNILPVTLLTAGILPQMMARKSGIIVNIGSAAGSIHMAKWSVYSATKKYIEWFTSILQKEYENEGIICQTITPLLVSTNMIKNPLSSIFCPNSDSFAKSSLNTIGNSSSTTGYITHQIQFELIKFVPEIIIDLFVKNLNNQLLDYQLDKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V0INJ4</accession>
    <name>A0A4V0INJ4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleolar protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F49E2.5</name>
        <name evidence="2 4" type="ORF">F49E2.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VTW47590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V0INJ4"/>
    <dbReference type="SMR" id="A0A4V0INJ4"/>
    <dbReference type="AGR" id="WB:WBGene00009888"/>
    <dbReference type="WormBase" id="F49E2.5t">
        <property type="protein sequence ID" value="CE53284"/>
        <property type="gene ID" value="WBGene00009888"/>
    </dbReference>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A4V0INJ4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006836">
        <property type="entry name" value="DUF612"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31765">
        <property type="entry name" value="PROTEIN CBG12783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31765:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04747">
        <property type="entry name" value="DUF612"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="165"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
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        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
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        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VTW47590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F49E2.5t"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A4V0INJ4"/>
        </source>
    </evidence>
    <sequence length="978" mass="107817" checksum="04C7B228D0B109A8" modified="2019-07-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V0INJ5</accession>
    <name>A0A4V0INJ5_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
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        <name evidence="4 6" type="primary">lgx-1</name>
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        <name evidence="4" type="ORF">CELE_C54G7.3</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NM_001373300.2"/>
    </dbReference>
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    <dbReference type="AGR" id="WB:WBGene00002983"/>
    <dbReference type="CTD" id="180825"/>
    <dbReference type="WormBase" id="C54G7.3h">
        <property type="protein sequence ID" value="CE53333"/>
        <property type="gene ID" value="WBGene00002983"/>
        <property type="gene designation" value="lgx-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A4V0INJ5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CE4"/>
    </dbReference>
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        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
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    </dbReference>
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        <property type="entry name" value="EB"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VTW47549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="C54G7.3h"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A4V0INJ5"/>
        </source>
    </evidence>
    <sequence length="1602" mass="173664" checksum="0875164BEF207BDA" modified="2019-07-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>B3KYC2</accession>
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        <submittedName>
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        <name evidence="2 4" type="primary">hrpr-1</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAQ76482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001136306.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3KYC2"/>
    <dbReference type="PeptideAtlas" id="B3KYC2"/>
    <dbReference type="GeneID" id="173086"/>
    <dbReference type="KEGG" id="cel:CELE_F58D5.1"/>
    <dbReference type="AGR" id="WB:WBGene00002000"/>
    <dbReference type="CTD" id="173086"/>
    <dbReference type="WormBase" id="F58D5.1b">
        <property type="protein sequence ID" value="CE42765"/>
        <property type="gene ID" value="WBGene00002000"/>
        <property type="gene designation" value="hrpr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022960_2_0_1"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
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            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAQ76482.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="B3KYC2"/>
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    </evidence>
    <sequence length="108" mass="10495" checksum="0340D53F29DE10BE" modified="2008-09-02" version="1">MPMPWGGGYGGDMGYGAYGGGYGGGYGGPGAYGDFGAYGGGGFRGGMRGSPRGGMGGGGGFRGGPPGRGGMANRRGRGKRPGDGRGGPASKRDNGKPDFSADVNMSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C8JQP0</accession>
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        <submittedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1 3" type="ORF">C29E4.13</name>
        <name evidence="1" type="ORF">CELE_C29E4.13</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD66017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379737.1">
        <property type="nucleotide sequence ID" value="NM_001392148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8JQP0"/>
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    <dbReference type="AGR" id="WB:WBGene00043051"/>
    <dbReference type="CTD" id="259332"/>
    <dbReference type="WormBase" id="C29E4.13c">
        <property type="protein sequence ID" value="CE44085"/>
        <property type="gene ID" value="WBGene00043051"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_947419_0_0_1"/>
    <dbReference type="OrthoDB" id="5837155at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00043051">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C8JQP0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD66017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C29E4.13c"/>
        </source>
    </evidence>
    <sequence length="205" mass="24358" checksum="52FBAE868779C631" modified="2009-10-13" version="1">MQAHPTHLSDRYLDEKDDILSQHKALPYCCHCNAIIKTWRGFEYHVLCTHLKYRPYRCFHCKKDGFYTEEEGRFHLSTRHPKDEVTLFKEYDPKKETAAREAFKQIFLICRDGPEVTKDRVHEWEREAEVEVMKFANLKFKRPIVLVRKLTSHSRQVQTPTYQNISLDSCQIPQTRPELQNIAINFRPMSVTTPHQDLSINRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8JQP4</accession>
    <name>C8JQP4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T04A6.3</name>
        <name evidence="2 4" type="ORF">T04A6.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254950.1">
        <property type="nucleotide sequence ID" value="NM_001268021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8JQP4"/>
    <dbReference type="GeneID" id="188037"/>
    <dbReference type="AGR" id="WB:WBGene00020202"/>
    <dbReference type="CTD" id="188037"/>
    <dbReference type="WormBase" id="T04A6.3a">
        <property type="protein sequence ID" value="CE44009"/>
        <property type="gene ID" value="WBGene00020202"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1429212_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020202">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C8JQP4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021010">
        <property type="entry name" value="Cytosolic_motility_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005514">
        <property type="entry name" value="DUF316"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578:SF3">
        <property type="entry name" value="NEMATODE SPECIFIC PEPTIDE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578">
        <property type="entry name" value="PROTEIN CBG21223-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03761">
        <property type="entry name" value="DUF316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002989419" evidence="1">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD73951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T04A6.3a"/>
        </source>
    </evidence>
    <sequence length="190" mass="21790" checksum="7123CE6BDE61900A" modified="2009-10-13" version="1">MKITQFLLFVILIVIPAVLSDDNDVRLENCGKRLEQSGSGNDTQDDWYGVLGRGSTYNTFTTIGLGAVTISRTHAIIDHSILKEKMVELDKSTCHEEQANVRLREDLYIYFMTSERDTSVHLLIRDSHFFGSCESENPKGFLVVKFEKPINLPYVCFPDNSWKWFNKSVNSYRLTNDSDHIIRTEGRVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D3TDG8</accession>
    <name>D3TDG8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">oac-59</name>
        <name evidence="3" type="ORF">C42C1.7</name>
        <name evidence="1" type="ORF">CELE_C42C1.7</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255637.1">
        <property type="nucleotide sequence ID" value="NM_001268708.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3TDG8"/>
    <dbReference type="SMR" id="D3TDG8"/>
    <dbReference type="GeneID" id="178180"/>
    <dbReference type="AGR" id="WB:WBGene00016585"/>
    <dbReference type="CTD" id="178180"/>
    <dbReference type="WormBase" id="C42C1.7b">
        <property type="protein sequence ID" value="CE44705"/>
        <property type="gene ID" value="WBGene00016585"/>
        <property type="gene designation" value="oac-59"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_12_1_1"/>
    <dbReference type="OrthoDB" id="5825384at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016585">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3TDG8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C42C1.7b"/>
        </source>
    </evidence>
    <sequence length="53" mass="6304" checksum="A7FCAAA212423453" modified="2010-04-20" version="1">MIDYEPLLFNKTSNRFEFFDNRGFLYFTGVNHLSAHGMELVRPIYTKICKDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D3TDG9</accession>
    <name>D3TDG9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C42C1.9</name>
        <name evidence="1" type="ORF">CELE_C42C1.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255635.1">
        <property type="nucleotide sequence ID" value="NM_001268706.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3TDG9"/>
    <dbReference type="SMR" id="D3TDG9"/>
    <dbReference type="GeneID" id="183401"/>
    <dbReference type="AGR" id="WB:WBGene00016587"/>
    <dbReference type="CTD" id="183401"/>
    <dbReference type="WormBase" id="C42C1.9b">
        <property type="protein sequence ID" value="CE44624"/>
        <property type="gene ID" value="WBGene00016587"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1103627_0_0_1"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016587">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3TDG9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C42C1.9b"/>
        </source>
    </evidence>
    <sequence length="82" mass="9234" checksum="867DCBEC07819CBA" modified="2010-04-20" version="1">MDSRAVDISQLGSVLFRCLTGHEHGSINLDSLPFVISPEGVKLAQKMMARKFCESVHYIINHTFIIENKKLSTARFLNLNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>D3YTA3</accession>
    <name>D3YTA3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y57G11C.5</name>
        <name evidence="2 4" type="ORF">Y57G11C.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255827.1">
        <property type="nucleotide sequence ID" value="NM_001268898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YTA3"/>
    <dbReference type="SMR" id="D3YTA3"/>
    <dbReference type="GeneID" id="190371"/>
    <dbReference type="AGR" id="WB:WBGene00013303"/>
    <dbReference type="CTD" id="190371"/>
    <dbReference type="WormBase" id="Y57G11C.5b">
        <property type="protein sequence ID" value="CE40536"/>
        <property type="gene ID" value="WBGene00013303"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036536_0_0_1"/>
    <dbReference type="OrthoDB" id="5845797at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013303">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YTA3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y57G11C.5b"/>
        </source>
    </evidence>
    <sequence length="512" mass="58792" checksum="609AFEADEE0A865A" modified="2010-04-20" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-01-20" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G4RT11-2</accession>
    <name>CDC26_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Anaphase-promoting complex subunit CDC26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cell division cycle protein 26 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cdc-26</name>
        <name evidence="6" type="synonym">mat-4</name>
        <name evidence="6" type="synonym">tag-265</name>
        <name evidence="6" type="ORF">B0511.9</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="BMC Dev. Biol." volume="7" first="19" last="19">
            <title>Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeast.</title>
            <authorList>
                <person name="Dong Y."/>
                <person name="Bogdanova A."/>
                <person name="Habermann B."/>
                <person name="Zachariae W."/>
                <person name="Ahringer J."/>
            </authorList>
            <dbReference type="PubMed" id="17374146"/>
            <dbReference type="DOI" id="10.1186/1471-213X-7-19"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G4RT11-1</id>
            <name evidence="6">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G4RT11-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_058039"/>
        </isoform>
        <isoform>
            <id>G4RT11-3</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_058040 VSP_058041 VSP_058038"/>
        </isoform>
        <isoform>
            <id>G4RT11-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_058038 VSP_058039 VSP_058037"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_740913.3">
        <property type="nucleotide sequence ID" value="NM_170919.7"/>
    </dbReference>
    <dbReference type="WormBase" id="B0511.9a">
        <property type="protein sequence ID" value="CE44875"/>
        <property type="gene ID" value="WBGene00015235"/>
        <property type="gene designation" value="cdc-26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q8NHZ8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="B0511.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="B0511.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="B0511.9c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="B0511.9d"/>
        </source>
    </evidence>
    <sequence length="193" mass="21138" checksum="029B69A15E8B7D62" modified="2012-01-25" version="2">MSMLRRPLTQLELCEDDIQWLTDQLNKRVLPAVIVPKCEMMDIDEMEPMDQSEPPRGITRRNLRSADRKNRDVPGPSTGECTRTSIAPTLTSARTPVAAPTLTLSTPVNPVSSAEMLRVMPPRVGRRPRASRSGDNDSPLLFNAYDTPQQGINDESPTPSDSPESPNAHLYATPGNPTSTSGGPSSNTRSHRH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-01-20" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G4RT11-3</accession>
    <name>CDC26_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Anaphase-promoting complex subunit CDC26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cell division cycle protein 26 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cdc-26</name>
        <name evidence="6" type="synonym">mat-4</name>
        <name evidence="6" type="synonym">tag-265</name>
        <name evidence="6" type="ORF">B0511.9</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="BMC Dev. Biol." volume="7" first="19" last="19">
            <title>Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeast.</title>
            <authorList>
                <person name="Dong Y."/>
                <person name="Bogdanova A."/>
                <person name="Habermann B."/>
                <person name="Zachariae W."/>
                <person name="Ahringer J."/>
            </authorList>
            <dbReference type="PubMed" id="17374146"/>
            <dbReference type="DOI" id="10.1186/1471-213X-7-19"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G4RT11-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_058038 VSP_058037 VSP_058039"/>
        </isoform>
        <isoform>
            <id>G4RT11-1</id>
            <name evidence="6">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G4RT11-3</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_058040 VSP_058038 VSP_058041"/>
        </isoform>
        <isoform>
            <id>G4RT11-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_058039"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_740914.2">
        <property type="nucleotide sequence ID" value="NM_171844.7"/>
    </dbReference>
    <dbReference type="WormBase" id="B0511.9b">
        <property type="protein sequence ID" value="CE41861"/>
        <property type="gene ID" value="WBGene00015235"/>
        <property type="gene designation" value="cdc-26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q8NHZ8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="B0511.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="B0511.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="B0511.9c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="B0511.9d"/>
        </source>
    </evidence>
    <sequence length="185" mass="20517" checksum="F948E804571BA5B0" modified="2012-01-25" version="2">MSMLRRPLTQLELCEDDIQWLTDQLNKRVLPAVIVPKCEMMDIDEMEPMDQSEPPRGITRRNLRSADRKNRDVPGPSTGECTRTSIAPNRCEMSFTEVQTLTSARTPVAAPTLTLSTPVNPVSSAEMLRVMPPRVGRRPRASRSGDNDSPLLFNAYDTPQQGINDESPTPSDSPESPNAHLYGGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-01-20" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G4RT11-4</accession>
    <name>CDC26_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of Anaphase-promoting complex subunit CDC26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cell division cycle protein 26 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cdc-26</name>
        <name evidence="6" type="synonym">mat-4</name>
        <name evidence="6" type="synonym">tag-265</name>
        <name evidence="6" type="ORF">B0511.9</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="BMC Dev. Biol." volume="7" first="19" last="19">
            <title>Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeast.</title>
            <authorList>
                <person name="Dong Y."/>
                <person name="Bogdanova A."/>
                <person name="Habermann B."/>
                <person name="Zachariae W."/>
                <person name="Ahringer J."/>
            </authorList>
            <dbReference type="PubMed" id="17374146"/>
            <dbReference type="DOI" id="10.1186/1471-213X-7-19"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G4RT11-3</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_058041 VSP_058040 VSP_058038"/>
        </isoform>
        <isoform>
            <id>G4RT11-1</id>
            <name evidence="6">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G4RT11-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_058039"/>
        </isoform>
        <isoform>
            <id>G4RT11-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_058039 VSP_058037 VSP_058038"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001251445.1">
        <property type="nucleotide sequence ID" value="NM_001264516.3"/>
    </dbReference>
    <dbReference type="WormBase" id="B0511.9d">
        <property type="protein sequence ID" value="CE46530"/>
        <property type="gene ID" value="WBGene00015235"/>
        <property type="gene designation" value="cdc-26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q8NHZ8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="B0511.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="B0511.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="B0511.9c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="B0511.9d"/>
        </source>
    </evidence>
    <sequence length="186" mass="20311" checksum="EDF9A4C69122E08B" modified="2012-01-25" version="2">MSMLRRPLTQLELSVIVPKCEMMDIDEMEPMDQSEPPRGITRRNLRSADRKNRDVPGPSTGECTRTSIAPNRCEMSFTEVQTLTSARTPVAAPTLTLSTPVNPVSSAEMLRVMPPRVGRRPRASRSGDNDSPLLFNAYDTPQQGINDESPTPSDSPESPNAHLYATPGNPTSTSGGPSSNTRSHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>G4RZC3</accession>
    <name>G4RZC3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="7">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="6">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">alh-6</name>
        <name evidence="9" type="ORF">CELE_F56D12.1</name>
        <name evidence="11" type="ORF">F56D12.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="6"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD64344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040782.1">
        <property type="nucleotide sequence ID" value="NM_001047317.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4RZC3"/>
    <dbReference type="SMR" id="G4RZC3"/>
    <dbReference type="PeptideAtlas" id="G4RZC3"/>
    <dbReference type="GeneID" id="173510"/>
    <dbReference type="AGR" id="WB:WBGene00000112"/>
    <dbReference type="CTD" id="173510"/>
    <dbReference type="WormBase" id="F56D12.1d">
        <property type="protein sequence ID" value="CE40074"/>
        <property type="gene ID" value="WBGene00000112"/>
        <property type="gene designation" value="alh-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_1"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000112">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G4RZC3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD64344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F56D12.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="G4RZC3"/>
        </source>
    </evidence>
    <sequence length="423" mass="45995" checksum="FC5C66A318840458" modified="2012-01-25" version="1">MKLNASTMLGQGKNIIQAEIDAACELIDFFRFNAVFAMELEHYEPISTKITKNTMQFRGMEGFVAAIAPFNFTAIGGNLPTAPALMGNVSLWKPSNTAVLSNYIIYELLEEAGMPPGILSFLPSDGPVFGDVITASPHLSAVNFTGSVPTFKTIWRKVAENLDNYVTFPKLIGECGGKNFHFVHPSAHVDAVAAGTARSAWEYSGQKCSACSRMYAPKSIWPKILEKISAIHKEIKLGDVRDGSVFLSAVIDDKAFARLKAYIDFAKTGADGANVVLGGKCDDKTGYFIEPTLITVTDPKSKLLTEEMFGPVVTVLVYEDSKVDEVLATVKDATPYGLTGAVFSQDKEFLYRARDVLRDAVGNMYLNDKSTGSIVGQQPFGGSRLSGTNDKAGGPHYGLRWTSPLTIKETSVSLTDWKYPSME</sequence>
</entry>
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    <accession>G4RZC9</accession>
    <name>G4RZC9_CAEEL</name>
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        <submittedName>
            <fullName evidence="9">JNK-interacting protein 1</fullName>
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        <name evidence="9" type="ORF">CELE_F56D12.4</name>
        <name evidence="11" type="ORF">F56D12.4</name>
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    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JIP scaffold family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCD64346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001038242.6"/>
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    <dbReference type="AlphaFoldDB" id="G4RZC9"/>
    <dbReference type="SMR" id="G4RZC9"/>
    <dbReference type="GeneID" id="173513"/>
    <dbReference type="KEGG" id="cel:CELE_F56D12.4"/>
    <dbReference type="AGR" id="WB:WBGene00002176"/>
    <dbReference type="CTD" id="173513"/>
    <dbReference type="WormBase" id="F56D12.4b">
        <property type="protein sequence ID" value="CE39160"/>
        <property type="gene ID" value="WBGene00002176"/>
        <property type="gene designation" value="jip-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5965083at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002176">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G4RZC9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046328">
        <property type="term" value="P:regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01212">
        <property type="entry name" value="PTB_JIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11801">
        <property type="entry name" value="SH3_JIP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000478">
        <property type="entry name" value="JNK Interacting Protein (Scaffold protein)"/>
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    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="SH3 Domains"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR047178">
        <property type="entry name" value="JIP1_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="294"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="450"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD64346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F56D12.4b"/>
        </source>
    </evidence>
    <sequence length="522" mass="58347" checksum="E987188BFB93F8CF" modified="2012-01-25" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>G5EBV0-2</accession>
    <name>EGL9_CAEEL</name>
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        <recommendedName>
            <fullName evidence="1">Isoform b of Hypoxia-inducible factor prolyl hydroxylase</fullName>
            <shortName evidence="5">HIF-PH</shortName>
            <ecNumber evidence="2 3">1.14.11.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Egg-laying defective protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Hypoxia-inducible factor-proline dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">egl-9</name>
        <name evidence="9" type="ORF">F22E12.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="1983" name="Genetics" volume="104" first="619" last="647">
            <title>Egg-laying defective mutants of the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Trent C."/>
                <person name="Tsuing N."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="11813735"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="1999" name="Proc. Natl. Acad. Sci. U.S.A." volume="96" first="15202" last="15207">
            <title>Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa.</title>
            <authorList>
                <person name="Darby C."/>
                <person name="Cosma C.L."/>
                <person name="Thomas J.H."/>
                <person name="Manoil C."/>
            </authorList>
            <dbReference type="PubMed" id="10611362"/>
            <dbReference type="DOI" id="10.1073/pnas.96.26.15202"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2001" name="Cell" volume="107" first="43" last="54">
            <title>C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.</title>
            <authorList>
                <person name="Epstein A.C.R."/>
                <person name="Gleadle J.M."/>
                <person name="McNeill L.A."/>
                <person name="Hewitson K.S."/>
                <person name="O'Rourke J."/>
                <person name="Mole D.R."/>
                <person name="Mukherji M."/>
                <person name="Metzen E."/>
                <person name="Wilson M.I."/>
                <person name="Dhanda A."/>
                <person name="Tian Y.M."/>
                <person name="Masson N."/>
                <person name="Hamilton D.L."/>
                <person name="Jaakkola P."/>
                <person name="Barstead R."/>
                <person name="Hodgkin J."/>
                <person name="Maxwell P.H."/>
                <person name="Pugh C.W."/>
                <person name="Schofield C.J."/>
                <person name="Ratcliffe P.J."/>
            </authorList>
            <dbReference type="PubMed" id="11595184"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(01)00507-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference evidence="6" key="5">
        <citation type="journal article" date="2001" name="J. Bacteriol." volume="183" first="6207" last="6214">
            <title>Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning.</title>
            <authorList>
                <person name="Gallagher L.A."/>
                <person name="Manoil C."/>
            </authorList>
            <dbReference type="PubMed" id="11591663"/>
            <dbReference type="DOI" id="10.1128/JB.183.21.6207-6214.2001"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="6" key="6">
        <citation type="journal article" date="2003" name="Physiol. Genomics" volume="14" first="17" last="24">
            <title>HIF-1 is required for heat acclimation in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Treinin M."/>
                <person name="Shliar J."/>
                <person name="Jiang H."/>
                <person name="Powell-Coffman J.A."/>
                <person name="Bromberg Z."/>
                <person name="Horowitz M."/>
            </authorList>
            <dbReference type="PubMed" id="12686697"/>
            <dbReference type="DOI" id="10.1152/physiolgenomics.00179.2002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="6" key="7">
        <citation type="journal article" date="2005" name="J. Biol. Chem." volume="280" first="20580" last="20588">
            <title>Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shen C."/>
                <person name="Nettleton D."/>
                <person name="Jiang M."/>
                <person name="Kim S.K."/>
                <person name="Powell-Coffman J.A."/>
            </authorList>
            <dbReference type="PubMed" id="15781453"/>
            <dbReference type="DOI" id="10.1074/jbc.M501894200"/>
        </citation>
        <scope>INDUCTION BY HYPOXIA</scope>
    </reference>
    <reference evidence="6" key="8">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="57" first="988" last="1007">
            <title>Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase gene.</title>
            <authorList>
                <person name="Anyanful A."/>
                <person name="Dolan-Livengood J.M."/>
                <person name="Lewis T."/>
                <person name="Sheth S."/>
                <person name="Dezalia M.N."/>
                <person name="Sherman M.A."/>
                <person name="Kalman L.V."/>
                <person name="Benian G.M."/>
                <person name="Kalman D."/>
            </authorList>
            <dbReference type="PubMed" id="16091039"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2005.04739.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="6" key="9">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="7321" last="7326">
            <title>Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chang A.J."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="18477695"/>
            <dbReference type="DOI" id="10.1073/pnas.0802164105"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="6" key="10">
        <citation type="journal article" date="2009" name="Genetics" volume="183" first="821" last="829">
            <title>Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shao Z."/>
                <person name="Zhang Y."/>
                <person name="Powell-Coffman J.A."/>
            </authorList>
            <dbReference type="PubMed" id="19737748"/>
            <dbReference type="DOI" id="10.1534/genetics.109.107284"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF HIS-487</scope>
    </reference>
    <reference evidence="6" key="11">
        <citation type="journal article" date="2009" name="PLoS Pathog." volume="5" first="E1000689" last="E1000689">
            <title>Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans.</title>
            <authorList>
                <person name="Bellier A."/>
                <person name="Chen C.S."/>
                <person name="Kao C.Y."/>
                <person name="Cinar H.N."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="20011506"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000689"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="6" key="12">
        <citation type="journal article" date="2009" name="Science" volume="324" first="1196" last="1198">
            <title>Proteasomal regulation of the hypoxic response modulates aging in C. elegans.</title>
            <authorList>
                <person name="Mehta R."/>
                <person name="Steinkraus K.A."/>
                <person name="Sutphin G.L."/>
                <person name="Ramos F.J."/>
                <person name="Shamieh L.S."/>
                <person name="Huh A."/>
                <person name="Davis C."/>
                <person name="Chandler-Brown D."/>
                <person name="Kaeberlein M."/>
            </authorList>
            <dbReference type="PubMed" id="19372390"/>
            <dbReference type="DOI" id="10.1126/science.1173507"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="6" key="13">
        <citation type="journal article" date="2010" name="PLoS Pathog." volume="6" first="E1001075" last="E1001075">
            <title>C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.</title>
            <authorList>
                <person name="Shao Z."/>
                <person name="Zhang Y."/>
                <person name="Ye Q."/>
                <person name="Saldanha J.N."/>
                <person name="Powell-Coffman J.A."/>
            </authorList>
            <dbReference type="PubMed" id="20865124"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1001075"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SWAN-1</scope>
    </reference>
    <reference evidence="6" key="14">
        <citation type="journal article" date="2012" name="EMBO J." volume="31" first="1379" last="1393">
            <title>Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism.</title>
            <authorList>
                <person name="Park E.C."/>
                <person name="Ghose P."/>
                <person name="Shao Z."/>
                <person name="Ye Q."/>
                <person name="Kang L."/>
                <person name="Xu X.Z."/>
                <person name="Powell-Coffman J.A."/>
                <person name="Rongo C."/>
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        <citation type="journal article" date="2012" name="Neuron" volume="73" first="925" last="940">
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            <authorList>
                <person name="Ma D.K."/>
                <person name="Vozdek R."/>
                <person name="Bhatla N."/>
                <person name="Horvitz H.R."/>
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        <scope>FUNCTION</scope>
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        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1002498" last="E1002498">
            <title>Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ackerman D."/>
                <person name="Gems D."/>
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            <dbReference type="PubMed" id="22396654"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002498"/>
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        <scope>FUNCTION</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002798" last="E1002798">
            <title>EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.</title>
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                <person name="Luhachack L.G."/>
                <person name="Visvikis O."/>
                <person name="Wollenberg A.C."/>
                <person name="Lacy-Hulbert A."/>
                <person name="Stuart L.M."/>
                <person name="Irazoqui J.E."/>
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        <scope>FUNCTION</scope>
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                <person name="Ghose P."/>
                <person name="Park E.C."/>
                <person name="Tabakin A."/>
                <person name="Salazar-Vasquez N."/>
                <person name="Rongo C."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1004063"/>
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        <citation type="journal article" date="1983" name="Genetics" volume="104" first="619" last="647">
            <title>Egg-laying defective mutants of the nematode Caenorhabditis elegans.</title>
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                <person name="Trent C."/>
                <person name="Tsuing N."/>
                <person name="Horvitz H.R."/>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">Bristol N2</strain>
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        <citation type="journal article" date="1999" name="Proc. Natl. Acad. Sci. U.S.A." volume="96" first="15202" last="15207">
            <title>Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa.</title>
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                <person name="Darby C."/>
                <person name="Cosma C.L."/>
                <person name="Thomas J.H."/>
                <person name="Manoil C."/>
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            <dbReference type="DOI" id="10.1073/pnas.96.26.15202"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
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            <strain evidence="5">Bristol N2</strain>
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    <reference evidence="7" key="4">
        <citation type="journal article" date="2001" name="Cell" volume="107" first="43" last="54">
            <title>C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.</title>
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                <person name="Epstein A.C.R."/>
                <person name="Gleadle J.M."/>
                <person name="McNeill L.A."/>
                <person name="Hewitson K.S."/>
                <person name="O'Rourke J."/>
                <person name="Mole D.R."/>
                <person name="Mukherji M."/>
                <person name="Metzen E."/>
                <person name="Wilson M.I."/>
                <person name="Dhanda A."/>
                <person name="Tian Y.M."/>
                <person name="Masson N."/>
                <person name="Hamilton D.L."/>
                <person name="Jaakkola P."/>
                <person name="Barstead R."/>
                <person name="Hodgkin J."/>
                <person name="Maxwell P.H."/>
                <person name="Pugh C.W."/>
                <person name="Schofield C.J."/>
                <person name="Ratcliffe P.J."/>
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            <dbReference type="DOI" id="10.1016/S0092-8674(01)00507-4"/>
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    <reference evidence="7" key="5">
        <citation type="journal article" date="2001" name="J. Bacteriol." volume="183" first="6207" last="6214">
            <title>Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning.</title>
            <authorList>
                <person name="Gallagher L.A."/>
                <person name="Manoil C."/>
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            <dbReference type="DOI" id="10.1128/JB.183.21.6207-6214.2001"/>
        </citation>
        <scope>FUNCTION</scope>
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    <reference evidence="7" key="6">
        <citation type="journal article" date="2003" name="Physiol. Genomics" volume="14" first="17" last="24">
            <title>HIF-1 is required for heat acclimation in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Treinin M."/>
                <person name="Shliar J."/>
                <person name="Jiang H."/>
                <person name="Powell-Coffman J.A."/>
                <person name="Bromberg Z."/>
                <person name="Horowitz M."/>
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            <dbReference type="DOI" id="10.1152/physiolgenomics.00179.2002"/>
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        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="7" key="7">
        <citation type="journal article" date="2005" name="J. Biol. Chem." volume="280" first="20580" last="20588">
            <title>Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shen C."/>
                <person name="Nettleton D."/>
                <person name="Jiang M."/>
                <person name="Kim S.K."/>
                <person name="Powell-Coffman J.A."/>
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            <dbReference type="PubMed" id="15781453"/>
            <dbReference type="DOI" id="10.1074/jbc.M501894200"/>
        </citation>
        <scope>INDUCTION BY HYPOXIA</scope>
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    <reference evidence="7" key="8">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="57" first="988" last="1007">
            <title>Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase gene.</title>
            <authorList>
                <person name="Anyanful A."/>
                <person name="Dolan-Livengood J.M."/>
                <person name="Lewis T."/>
                <person name="Sheth S."/>
                <person name="Dezalia M.N."/>
                <person name="Sherman M.A."/>
                <person name="Kalman L.V."/>
                <person name="Benian G.M."/>
                <person name="Kalman D."/>
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            <dbReference type="PubMed" id="16091039"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2005.04739.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="7" key="9">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="7321" last="7326">
            <title>Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chang A.J."/>
                <person name="Bargmann C.I."/>
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            <dbReference type="PubMed" id="18477695"/>
            <dbReference type="DOI" id="10.1073/pnas.0802164105"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="7" key="10">
        <citation type="journal article" date="2009" name="Genetics" volume="183" first="821" last="829">
            <title>Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shao Z."/>
                <person name="Zhang Y."/>
                <person name="Powell-Coffman J.A."/>
            </authorList>
            <dbReference type="PubMed" id="19737748"/>
            <dbReference type="DOI" id="10.1534/genetics.109.107284"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF HIS-487</scope>
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    <reference evidence="7" key="11">
        <citation type="journal article" date="2009" name="PLoS Pathog." volume="5" first="E1000689" last="E1000689">
            <title>Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans.</title>
            <authorList>
                <person name="Bellier A."/>
                <person name="Chen C.S."/>
                <person name="Kao C.Y."/>
                <person name="Cinar H.N."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="20011506"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000689"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="7" key="12">
        <citation type="journal article" date="2009" name="Science" volume="324" first="1196" last="1198">
            <title>Proteasomal regulation of the hypoxic response modulates aging in C. elegans.</title>
            <authorList>
                <person name="Mehta R."/>
                <person name="Steinkraus K.A."/>
                <person name="Sutphin G.L."/>
                <person name="Ramos F.J."/>
                <person name="Shamieh L.S."/>
                <person name="Huh A."/>
                <person name="Davis C."/>
                <person name="Chandler-Brown D."/>
                <person name="Kaeberlein M."/>
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            <dbReference type="PubMed" id="19372390"/>
            <dbReference type="DOI" id="10.1126/science.1173507"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="7" key="13">
        <citation type="journal article" date="2010" name="PLoS Pathog." volume="6" first="E1001075" last="E1001075">
            <title>C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.</title>
            <authorList>
                <person name="Shao Z."/>
                <person name="Zhang Y."/>
                <person name="Ye Q."/>
                <person name="Saldanha J.N."/>
                <person name="Powell-Coffman J.A."/>
            </authorList>
            <dbReference type="PubMed" id="20865124"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1001075"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SWAN-1</scope>
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    <reference evidence="7" key="14">
        <citation type="journal article" date="2012" name="EMBO J." volume="31" first="1379" last="1393">
            <title>Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism.</title>
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                <person name="Park E.C."/>
                <person name="Ghose P."/>
                <person name="Shao Z."/>
                <person name="Ye Q."/>
                <person name="Kang L."/>
                <person name="Xu X.Z."/>
                <person name="Powell-Coffman J.A."/>
                <person name="Rongo C."/>
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            <dbReference type="PubMed" id="22252129"/>
            <dbReference type="DOI" id="10.1038/emboj.2011.499"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH LIN-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF HIS-487</scope>
        <scope>CHARACTERIZATION OF ISOFORMS A; C AND E</scope>
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    <reference evidence="7" key="15">
        <citation type="journal article" date="2012" name="Neuron" volume="73" first="925" last="940">
            <title>CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans.</title>
            <authorList>
                <person name="Ma D.K."/>
                <person name="Vozdek R."/>
                <person name="Bhatla N."/>
                <person name="Horvitz H.R."/>
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            <dbReference type="DOI" id="10.1016/j.neuron.2011.12.037"/>
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        <scope>FUNCTION</scope>
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        <scope>MUTAGENESIS OF GLU-720</scope>
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    <reference evidence="7" key="16">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1002498" last="E1002498">
            <title>Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ackerman D."/>
                <person name="Gems D."/>
            </authorList>
            <dbReference type="PubMed" id="22396654"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002498"/>
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        <scope>FUNCTION</scope>
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    <reference evidence="7" key="17">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002798" last="E1002798">
            <title>EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.</title>
            <authorList>
                <person name="Luhachack L.G."/>
                <person name="Visvikis O."/>
                <person name="Wollenberg A.C."/>
                <person name="Lacy-Hulbert A."/>
                <person name="Stuart L.M."/>
                <person name="Irazoqui J.E."/>
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            <dbReference type="PubMed" id="22792069"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002798"/>
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        <scope>FUNCTION</scope>
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    <reference evidence="7" key="18">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1004063" last="E1004063">
            <title>Anoxia-reoxygenation regulates mitochondrial dynamics through the hypoxia response pathway, SKN-1/Nrf, and stomatin-like protein STL-1/SLP-2.</title>
            <authorList>
                <person name="Ghose P."/>
                <person name="Park E.C."/>
                <person name="Tabakin A."/>
                <person name="Salazar-Vasquez N."/>
                <person name="Rongo C."/>
            </authorList>
            <dbReference type="PubMed" id="24385935"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004063"/>
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        <scope>FUNCTION</scope>
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        <text evidence="4">In interneurons, localizes throughout the ventral cord dendrites.</text>
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        <isoform>
            <id>G5EBV0-1</id>
            <name evidence="10">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EBV0-2</id>
            <name evidence="11">b</name>
            <sequence type="described" ref="VSP_057747 VSP_057748"/>
        </isoform>
        <isoform>
            <id>G5EBV0-3</id>
            <name evidence="12">c</name>
            <sequence type="described" ref="VSP_057745"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="1.14.11.29" evidence="2 3"/>
    <dbReference type="RefSeq" id="NP_001023833.1">
        <property type="nucleotide sequence ID" value="NM_001028662.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F22E12.4c">
        <property type="protein sequence ID" value="CE38327"/>
        <property type="gene ID" value="WBGene00001178"/>
        <property type="gene designation" value="egl-9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9GZT9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="11595184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="19737748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22252129"/>
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    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="10611362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="11595184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="AAD56365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="F22E12.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="F22E12.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="F22E12.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="F22E12.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="F22E12.4e"/>
        </source>
    </evidence>
    <sequence length="465" mass="52901" checksum="F199FF2BE1BEFA82" modified="2011-12-14" version="1">MPLRTIVAPTSYGIPTPMPSQSRWKPYSKTMKPSIIETEGGSKPTVSRTRKRPTPSNSADPKINYKDHNKNVVYSTTLQEHQKHLQNRGLALSIHQAMVLRLRYIAEHVIRSLNEFGWAVVDNFLGSDHYKFTAKEIERLYERGLFSPGQLMEAKHKDEFHIKDIRSDHIYWYDGYDGRAKDAATVRLLISMIDSVIQHFKKRIDHDIGGRSRAMLAIYPGNGTRYVKHVDNPVKDGRCITTIYYCNENWDMATDGGTLRLYPETSMTPMDIDPRADRLVFFWSDRRNPHEVMPVFRHRFAITIWYMDKSERDKALAKGKESDAACASKKENDPTSSSLNSLIGSLLRPRKNPSTHDLSKLDLRLFPSTSSDPALVSAADEDRVDISADFQSTSSLAHPESTDSGVSLSTFNVAHNHMERTTSLQSISDHFRSERSHERRSSTSSDQDLDEGLPPPPSTNPEYYI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>G5EBV0-4</accession>
    <name>EGL9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of Hypoxia-inducible factor prolyl hydroxylase</fullName>
            <shortName evidence="5">HIF-PH</shortName>
            <ecNumber evidence="2 3">1.14.11.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Egg-laying defective protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Hypoxia-inducible factor-proline dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">egl-9</name>
        <name evidence="9" type="ORF">F22E12.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="1983" name="Genetics" volume="104" first="619" last="647">
            <title>Egg-laying defective mutants of the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Trent C."/>
                <person name="Tsuing N."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="11813735"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="1999" name="Proc. Natl. Acad. Sci. U.S.A." volume="96" first="15202" last="15207">
            <title>Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa.</title>
            <authorList>
                <person name="Darby C."/>
                <person name="Cosma C.L."/>
                <person name="Thomas J.H."/>
                <person name="Manoil C."/>
            </authorList>
            <dbReference type="PubMed" id="10611362"/>
            <dbReference type="DOI" id="10.1073/pnas.96.26.15202"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2001" name="Cell" volume="107" first="43" last="54">
            <title>C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.</title>
            <authorList>
                <person name="Epstein A.C.R."/>
                <person name="Gleadle J.M."/>
                <person name="McNeill L.A."/>
                <person name="Hewitson K.S."/>
                <person name="O'Rourke J."/>
                <person name="Mole D.R."/>
                <person name="Mukherji M."/>
                <person name="Metzen E."/>
                <person name="Wilson M.I."/>
                <person name="Dhanda A."/>
                <person name="Tian Y.M."/>
                <person name="Masson N."/>
                <person name="Hamilton D.L."/>
                <person name="Jaakkola P."/>
                <person name="Barstead R."/>
                <person name="Hodgkin J."/>
                <person name="Maxwell P.H."/>
                <person name="Pugh C.W."/>
                <person name="Schofield C.J."/>
                <person name="Ratcliffe P.J."/>
            </authorList>
            <dbReference type="PubMed" id="11595184"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(01)00507-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference evidence="6" key="5">
        <citation type="journal article" date="2001" name="J. Bacteriol." volume="183" first="6207" last="6214">
            <title>Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning.</title>
            <authorList>
                <person name="Gallagher L.A."/>
                <person name="Manoil C."/>
            </authorList>
            <dbReference type="PubMed" id="11591663"/>
            <dbReference type="DOI" id="10.1128/JB.183.21.6207-6214.2001"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="6" key="6">
        <citation type="journal article" date="2003" name="Physiol. Genomics" volume="14" first="17" last="24">
            <title>HIF-1 is required for heat acclimation in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Treinin M."/>
                <person name="Shliar J."/>
                <person name="Jiang H."/>
                <person name="Powell-Coffman J.A."/>
                <person name="Bromberg Z."/>
                <person name="Horowitz M."/>
            </authorList>
            <dbReference type="PubMed" id="12686697"/>
            <dbReference type="DOI" id="10.1152/physiolgenomics.00179.2002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="6" key="7">
        <citation type="journal article" date="2005" name="J. Biol. Chem." volume="280" first="20580" last="20588">
            <title>Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shen C."/>
                <person name="Nettleton D."/>
                <person name="Jiang M."/>
                <person name="Kim S.K."/>
                <person name="Powell-Coffman J.A."/>
            </authorList>
            <dbReference type="PubMed" id="15781453"/>
            <dbReference type="DOI" id="10.1074/jbc.M501894200"/>
        </citation>
        <scope>INDUCTION BY HYPOXIA</scope>
    </reference>
    <reference evidence="6" key="8">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="57" first="988" last="1007">
            <title>Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase gene.</title>
            <authorList>
                <person name="Anyanful A."/>
                <person name="Dolan-Livengood J.M."/>
                <person name="Lewis T."/>
                <person name="Sheth S."/>
                <person name="Dezalia M.N."/>
                <person name="Sherman M.A."/>
                <person name="Kalman L.V."/>
                <person name="Benian G.M."/>
                <person name="Kalman D."/>
            </authorList>
            <dbReference type="PubMed" id="16091039"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2005.04739.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="6" key="9">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="7321" last="7326">
            <title>Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chang A.J."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="18477695"/>
            <dbReference type="DOI" id="10.1073/pnas.0802164105"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="6" key="10">
        <citation type="journal article" date="2009" name="Genetics" volume="183" first="821" last="829">
            <title>Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shao Z."/>
                <person name="Zhang Y."/>
                <person name="Powell-Coffman J.A."/>
            </authorList>
            <dbReference type="PubMed" id="19737748"/>
            <dbReference type="DOI" id="10.1534/genetics.109.107284"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF HIS-487</scope>
    </reference>
    <reference evidence="6" key="11">
        <citation type="journal article" date="2009" name="PLoS Pathog." volume="5" first="E1000689" last="E1000689">
            <title>Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans.</title>
            <authorList>
                <person name="Bellier A."/>
                <person name="Chen C.S."/>
                <person name="Kao C.Y."/>
                <person name="Cinar H.N."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="20011506"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000689"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="6" key="12">
        <citation type="journal article" date="2009" name="Science" volume="324" first="1196" last="1198">
            <title>Proteasomal regulation of the hypoxic response modulates aging in C. elegans.</title>
            <authorList>
                <person name="Mehta R."/>
                <person name="Steinkraus K.A."/>
                <person name="Sutphin G.L."/>
                <person name="Ramos F.J."/>
                <person name="Shamieh L.S."/>
                <person name="Huh A."/>
                <person name="Davis C."/>
                <person name="Chandler-Brown D."/>
                <person name="Kaeberlein M."/>
            </authorList>
            <dbReference type="PubMed" id="19372390"/>
            <dbReference type="DOI" id="10.1126/science.1173507"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="6" key="13">
        <citation type="journal article" date="2010" name="PLoS Pathog." volume="6" first="E1001075" last="E1001075">
            <title>C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.</title>
            <authorList>
                <person name="Shao Z."/>
                <person name="Zhang Y."/>
                <person name="Ye Q."/>
                <person name="Saldanha J.N."/>
                <person name="Powell-Coffman J.A."/>
            </authorList>
            <dbReference type="PubMed" id="20865124"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1001075"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SWAN-1</scope>
    </reference>
    <reference evidence="6" key="14">
        <citation type="journal article" date="2012" name="EMBO J." volume="31" first="1379" last="1393">
            <title>Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism.</title>
            <authorList>
                <person name="Park E.C."/>
                <person name="Ghose P."/>
                <person name="Shao Z."/>
                <person name="Ye Q."/>
                <person name="Kang L."/>
                <person name="Xu X.Z."/>
                <person name="Powell-Coffman J.A."/>
                <person name="Rongo C."/>
            </authorList>
            <dbReference type="PubMed" id="22252129"/>
            <dbReference type="DOI" id="10.1038/emboj.2011.499"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH LIN-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF HIS-487</scope>
        <scope>CHARACTERIZATION OF ISOFORMS A; C AND E</scope>
    </reference>
    <reference evidence="6" key="15">
        <citation type="journal article" date="2012" name="Neuron" volume="73" first="925" last="940">
            <title>CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans.</title>
            <authorList>
                <person name="Ma D.K."/>
                <person name="Vozdek R."/>
                <person name="Bhatla N."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="22405203"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2011.12.037"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CYSL-1</scope>
        <scope>MUTAGENESIS OF GLU-720</scope>
    </reference>
    <reference evidence="6" key="16">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1002498" last="E1002498">
            <title>Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ackerman D."/>
                <person name="Gems D."/>
            </authorList>
            <dbReference type="PubMed" id="22396654"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002498"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="6" key="17">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002798" last="E1002798">
            <title>EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.</title>
            <authorList>
                <person name="Luhachack L.G."/>
                <person name="Visvikis O."/>
                <person name="Wollenberg A.C."/>
                <person name="Lacy-Hulbert A."/>
                <person name="Stuart L.M."/>
                <person name="Irazoqui J.E."/>
            </authorList>
            <dbReference type="PubMed" id="22792069"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002798"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference evidence="6" key="18">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1004063" last="E1004063">
            <title>Anoxia-reoxygenation regulates mitochondrial dynamics through the hypoxia response pathway, SKN-1/Nrf, and stomatin-like protein STL-1/SLP-2.</title>
            <authorList>
                <person name="Ghose P."/>
                <person name="Park E.C."/>
                <person name="Tabakin A."/>
                <person name="Salazar-Vasquez N."/>
                <person name="Rongo C."/>
            </authorList>
            <dbReference type="PubMed" id="24385935"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004063"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EBV0-4</id>
            <name evidence="12">d</name>
            <sequence type="described" ref="VSP_057749"/>
        </isoform>
        <isoform>
            <id>G5EBV0-2</id>
            <name evidence="10">b</name>
            <sequence type="described" ref="VSP_057747 VSP_057748"/>
        </isoform>
        <isoform>
            <id>G5EBV0-1</id>
            <name evidence="9">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EBV0-3</id>
            <name evidence="11">c</name>
            <sequence type="described" ref="VSP_057745"/>
        </isoform>
        <isoform>
            <id>G5EBV0-5</id>
            <name evidence="13">e</name>
            <sequence type="described" ref="VSP_057746"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="1.14.11.29" evidence="2 3"/>
    <dbReference type="RefSeq" id="NP_001023834.1">
        <property type="nucleotide sequence ID" value="NM_001028663.6"/>
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    <dbReference type="WormBase" id="F22E12.4d">
        <property type="protein sequence ID" value="CE38328"/>
        <property type="gene ID" value="WBGene00001178"/>
        <property type="gene designation" value="egl-9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9GZT9"/>
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    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="11595184"/>
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    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="19737748"/>
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    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="10611362"/>
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    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="11595184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="AAD56365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="F22E12.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="F22E12.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="F22E12.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="F22E12.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="F22E12.4e"/>
        </source>
    </evidence>
    <sequence length="702" mass="77567" checksum="41776D4E8A8881E0" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>G5EBV0-5</accession>
    <name>EGL9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform e of Hypoxia-inducible factor prolyl hydroxylase</fullName>
            <shortName evidence="6">HIF-PH</shortName>
            <ecNumber evidence="2 3">1.14.11.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Egg-laying defective protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Hypoxia-inducible factor-proline dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">egl-9</name>
        <name evidence="10" type="ORF">F22E12.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="1983" name="Genetics" volume="104" first="619" last="647">
            <title>Egg-laying defective mutants of the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Trent C."/>
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            </authorList>
            <dbReference type="PubMed" id="11813735"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
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            <title>Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa.</title>
            <authorList>
                <person name="Darby C."/>
                <person name="Cosma C.L."/>
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                <person name="Manoil C."/>
            </authorList>
            <dbReference type="PubMed" id="10611362"/>
            <dbReference type="DOI" id="10.1073/pnas.96.26.15202"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
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            <title>C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.</title>
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                <person name="Epstein A.C.R."/>
                <person name="Gleadle J.M."/>
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                <person name="Dhanda A."/>
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                <person name="Masson N."/>
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                <person name="Pugh C.W."/>
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            <dbReference type="PubMed" id="11595184"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(01)00507-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference evidence="7" key="5">
        <citation type="journal article" date="2001" name="J. Bacteriol." volume="183" first="6207" last="6214">
            <title>Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning.</title>
            <authorList>
                <person name="Gallagher L.A."/>
                <person name="Manoil C."/>
            </authorList>
            <dbReference type="PubMed" id="11591663"/>
            <dbReference type="DOI" id="10.1128/JB.183.21.6207-6214.2001"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="7" key="6">
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            <title>HIF-1 is required for heat acclimation in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Treinin M."/>
                <person name="Shliar J."/>
                <person name="Jiang H."/>
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                <person name="Bromberg Z."/>
                <person name="Horowitz M."/>
            </authorList>
            <dbReference type="PubMed" id="12686697"/>
            <dbReference type="DOI" id="10.1152/physiolgenomics.00179.2002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="7" key="7">
        <citation type="journal article" date="2005" name="J. Biol. Chem." volume="280" first="20580" last="20588">
            <title>Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shen C."/>
                <person name="Nettleton D."/>
                <person name="Jiang M."/>
                <person name="Kim S.K."/>
                <person name="Powell-Coffman J.A."/>
            </authorList>
            <dbReference type="PubMed" id="15781453"/>
            <dbReference type="DOI" id="10.1074/jbc.M501894200"/>
        </citation>
        <scope>INDUCTION BY HYPOXIA</scope>
    </reference>
    <reference evidence="7" key="8">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="57" first="988" last="1007">
            <title>Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase gene.</title>
            <authorList>
                <person name="Anyanful A."/>
                <person name="Dolan-Livengood J.M."/>
                <person name="Lewis T."/>
                <person name="Sheth S."/>
                <person name="Dezalia M.N."/>
                <person name="Sherman M.A."/>
                <person name="Kalman L.V."/>
                <person name="Benian G.M."/>
                <person name="Kalman D."/>
            </authorList>
            <dbReference type="PubMed" id="16091039"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2005.04739.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="7" key="9">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="7321" last="7326">
            <title>Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chang A.J."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="18477695"/>
            <dbReference type="DOI" id="10.1073/pnas.0802164105"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="7" key="10">
        <citation type="journal article" date="2009" name="Genetics" volume="183" first="821" last="829">
            <title>Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shao Z."/>
                <person name="Zhang Y."/>
                <person name="Powell-Coffman J.A."/>
            </authorList>
            <dbReference type="PubMed" id="19737748"/>
            <dbReference type="DOI" id="10.1534/genetics.109.107284"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF HIS-487</scope>
    </reference>
    <reference evidence="7" key="11">
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            <title>Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans.</title>
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                <person name="Bellier A."/>
                <person name="Chen C.S."/>
                <person name="Kao C.Y."/>
                <person name="Cinar H.N."/>
                <person name="Aroian R.V."/>
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            <dbReference type="PubMed" id="20011506"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000689"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="7" key="12">
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            <title>Proteasomal regulation of the hypoxic response modulates aging in C. elegans.</title>
            <authorList>
                <person name="Mehta R."/>
                <person name="Steinkraus K.A."/>
                <person name="Sutphin G.L."/>
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            <dbReference type="PubMed" id="19372390"/>
            <dbReference type="DOI" id="10.1126/science.1173507"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="7" key="13">
        <citation type="journal article" date="2010" name="PLoS Pathog." volume="6" first="E1001075" last="E1001075">
            <title>C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.</title>
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                <person name="Shao Z."/>
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                <person name="Ye Q."/>
                <person name="Saldanha J.N."/>
                <person name="Powell-Coffman J.A."/>
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            <dbReference type="PubMed" id="20865124"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1001075"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SWAN-1</scope>
    </reference>
    <reference evidence="7" key="14">
        <citation type="journal article" date="2012" name="EMBO J." volume="31" first="1379" last="1393">
            <title>Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism.</title>
            <authorList>
                <person name="Park E.C."/>
                <person name="Ghose P."/>
                <person name="Shao Z."/>
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                <person name="Kang L."/>
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            </authorList>
            <dbReference type="PubMed" id="22252129"/>
            <dbReference type="DOI" id="10.1038/emboj.2011.499"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH LIN-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF HIS-487</scope>
        <scope>CHARACTERIZATION OF ISOFORMS A; C AND E</scope>
    </reference>
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        <citation type="journal article" date="2012" name="Neuron" volume="73" first="925" last="940">
            <title>CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans.</title>
            <authorList>
                <person name="Ma D.K."/>
                <person name="Vozdek R."/>
                <person name="Bhatla N."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="22405203"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2011.12.037"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CYSL-1</scope>
        <scope>MUTAGENESIS OF GLU-720</scope>
    </reference>
    <reference evidence="7" key="16">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1002498" last="E1002498">
            <title>Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ackerman D."/>
                <person name="Gems D."/>
            </authorList>
            <dbReference type="PubMed" id="22396654"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002498"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="7" key="17">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002798" last="E1002798">
            <title>EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.</title>
            <authorList>
                <person name="Luhachack L.G."/>
                <person name="Visvikis O."/>
                <person name="Wollenberg A.C."/>
                <person name="Lacy-Hulbert A."/>
                <person name="Stuart L.M."/>
                <person name="Irazoqui J.E."/>
            </authorList>
            <dbReference type="PubMed" id="22792069"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002798"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference evidence="7" key="18">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1004063" last="E1004063">
            <title>Anoxia-reoxygenation regulates mitochondrial dynamics through the hypoxia response pathway, SKN-1/Nrf, and stomatin-like protein STL-1/SLP-2.</title>
            <authorList>
                <person name="Ghose P."/>
                <person name="Park E.C."/>
                <person name="Tabakin A."/>
                <person name="Salazar-Vasquez N."/>
                <person name="Rongo C."/>
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            <dbReference type="PubMed" id="24385935"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004063"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the trafficking of the glutamate receptor glr-1, probably independently of hif-1, by regulating lin-10 subcellular localization in response to oxygen levels. May hydroxylate lin-10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <text evidence="4">In interneurons, localizes in puncta (which probably correspond to endosomes) along the ventral cord. Localization to puncta is regulated by oxygen levels. Co-localizes with lin-10 in puncta.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EBV0-3</id>
            <name evidence="12">c</name>
            <sequence type="described" ref="VSP_057745"/>
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        <isoform>
            <id>G5EBV0-2</id>
            <name evidence="11">b</name>
            <sequence type="described" ref="VSP_057748 VSP_057747"/>
        </isoform>
        <isoform>
            <id>G5EBV0-4</id>
            <name evidence="13">d</name>
            <sequence type="described" ref="VSP_057749"/>
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        <isoform>
            <id>G5EBV0-5</id>
            <name evidence="14">e</name>
            <sequence type="described" ref="VSP_057746"/>
        </isoform>
        <isoform>
            <id>G5EBV0-1</id>
            <name evidence="10">a</name>
            <sequence type="displayed"/>
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    </comment>
    <dbReference type="EC" id="1.14.11.29" evidence="2 3"/>
    <dbReference type="RefSeq" id="NP_001041105.1">
        <property type="nucleotide sequence ID" value="NM_001047640.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F22E12.4e">
        <property type="protein sequence ID" value="CE40254"/>
        <property type="gene ID" value="WBGene00001178"/>
        <property type="gene designation" value="egl-9"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
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    <proteinExistence type="evidence at protein level"/>
    <feature type="mutagenesis site" description="Loss of hydroxylase activity resulting in loss of oxygen-mediated hif-1 degradation. Inhibition of hif-1 transcriptional activity, which is independent of egl-9 hydroxylase activity, is only slightly affected. Loss of glr-1 recycling; in isoform e." evidence="3 4">
        <original>H</original>
        <variation>A</variation>
        <location>
            <position position="487"/>
        </location>
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    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9GZT9"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22252129"/>
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    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="AAD56365.1"/>
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    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="F22E12.4b"/>
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    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="F22E12.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="F22E12.4d"/>
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    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="F22E12.4e"/>
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    </evidence>
    <sequence length="647" mass="71585" checksum="981EB21320A1B4A6" modified="2011-12-14" version="1"> </sequence>
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<entry dataset="Swiss-Prot" created="2017-06-07" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>G5EF33-2</accession>
    <name>MIG13_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Abnormal cell migration protein 13</fullName>
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    <gene>
        <name evidence="4" type="primary">mig-13</name>
        <name evidence="4" type="ORF">F43C9.4</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="1996" name="Development" volume="122" first="3117" last="3131">
            <title>Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position.</title>
            <authorList>
                <person name="Harris J."/>
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            <dbReference type="PubMed" id="8898225"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="3" key="2">
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                <consortium name="The C. elegans sequencing consortium"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
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                <person name="Sym M."/>
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            <dbReference type="PubMed" id="10412978"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(00)80603-0"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-190</scope>
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    <reference evidence="1" key="4">
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            <authorList>
                <person name="Yang L."/>
                <person name="Sym M."/>
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            <dbReference type="PubMed" id="15750187"/>
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        <scope>FUNCTION</scope>
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    <reference evidence="1" key="5">
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            <title>MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Masuda H."/>
                <person name="Nakamura K."/>
                <person name="Takata N."/>
                <person name="Itoh B."/>
                <person name="Hirose T."/>
                <person name="Moribe H."/>
                <person name="Mekada E."/>
                <person name="Okada M."/>
            </authorList>
            <dbReference type="PubMed" id="22293500"/>
            <dbReference type="DOI" id="10.1016/j.febslet.2012.01.031"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="11175" last="11180">
            <title>Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.</title>
            <authorList>
                <person name="Wang X."/>
                <person name="Zhou F."/>
                <person name="Lv S."/>
                <person name="Yi P."/>
                <person name="Zhu Z."/>
                <person name="Yang Y."/>
                <person name="Feng G."/>
                <person name="Li W."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="23784779"/>
            <dbReference type="DOI" id="10.1073/pnas.1301849110"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF GLY-167</scope>
    </reference>
    <reference evidence="1" key="7">
        <citation type="journal article" date="2015" name="G3 (Bethesda)" volume="5" first="1567" last="1574">
            <title>SDN-1/Syndecan acts in parallel to the transmembrane molecule MIG-13 to promote anterior neuroblast migration.</title>
            <authorList>
                <person name="Sundararajan L."/>
                <person name="Norris M.L."/>
                <person name="Lundquist E.A."/>
            </authorList>
            <dbReference type="PubMed" id="26022293"/>
            <dbReference type="DOI" id="10.1534/g3.115.018770"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="8">
        <citation type="journal article" date="2016" name="Dev. Cell" volume="39" first="224" last="238">
            <title>Functional coordination of WAVE and WASP in C. elegans neuroblast migration.</title>
            <authorList>
                <person name="Zhu Z."/>
                <person name="Chai Y."/>
                <person name="Jiang Y."/>
                <person name="Li W."/>
                <person name="Hu H."/>
                <person name="Li W."/>
                <person name="Wu J.W."/>
                <person name="Wang Z.X."/>
                <person name="Huang S."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="27780040"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2016.09.029"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ABL-1 AND SEM-5</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="9">
        <citation type="journal article" date="2016" name="FEBS Lett." volume="590" first="76" last="92">
            <title>A novel bipartite UNC-101/AP-1 mu1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhou X."/>
                <person name="Zeng J."/>
                <person name="Ouyang C."/>
                <person name="Luo Q."/>
                <person name="Yu M."/>
                <person name="Yang Z."/>
                <person name="Wang H."/>
                <person name="Shen K."/>
                <person name="Shi A."/>
            </authorList>
            <dbReference type="PubMed" id="26762178"/>
            <dbReference type="DOI" id="10.1002/1873-3468.12043"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EF33-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_058961"/>
        </isoform>
        <isoform>
            <id>G5EF33-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024661.1">
        <property type="nucleotide sequence ID" value="NM_001029490.5"/>
    </dbReference>
    <dbReference type="WormBase" id="F43C9.4b">
        <property type="protein sequence ID" value="CE34562"/>
        <property type="gene ID" value="WBGene00003245"/>
        <property type="gene designation" value="mig-13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAD43178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F43C9.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F43C9.4b"/>
        </source>
    </evidence>
    <sequence length="356" mass="39441" checksum="A4B65577714E0764" modified="2011-12-14" version="1" precursor="true">MICIIFLSDSITSTCFYSGFFDGLDSRNECKARLDRRLTGFSGLLYSHSKYGQEPYNTSRNCVLMLVAPIGYSIRVRALQFDVASTENARTCEKDTLHVFDHETTLDPESYAPARIDDITSPGPIIGQFCGHFENRILNTSSHNALTLWWHSNPNGSNSKGFKLHWGSFRVSKTGNCVTGEFSCGNGECIPIESACDRFADCSNGEDLIHSRQMAANCQNIELDPLTTVSGVFVLLFSATIILSLCGFIMFVCCLCKCLKSTIPIKGASSHTTTTTATDYKPDPPQFYPPSPPKMPPPSAASSYTPRLHHHFEGPLVPSETSAFHSSNRMQNHYSVNSDINGDYTYVRNDVHRNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLF4</accession>
    <name>H2FLF4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CELE_ZK512.2</name>
        <name evidence="11 13" type="ORF">ZK512.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCF23444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254981.1">
        <property type="nucleotide sequence ID" value="NM_001268052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLF4"/>
    <dbReference type="SMR" id="H2FLF4"/>
    <dbReference type="PeptideAtlas" id="H2FLF4"/>
    <dbReference type="GeneID" id="176292"/>
    <dbReference type="AGR" id="WB:WBGene00013983"/>
    <dbReference type="CTD" id="176292"/>
    <dbReference type="WormBase" id="ZK512.2b">
        <property type="protein sequence ID" value="CE46834"/>
        <property type="gene ID" value="WBGene00013983"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_4_1"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013983">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLF4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="165"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="441"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF23444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="ZK512.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="H2FLF4"/>
        </source>
    </evidence>
    <sequence length="512" mass="58723" checksum="EE88E2FD49774ED0" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLF8</accession>
    <name>H2FLF8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Degenerin-like protein unc-105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">unc-105</name>
        <name evidence="18" type="ORF">C41C4.5</name>
        <name evidence="16" type="ORF">CELE_C41C4.5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCF23432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368112.1">
        <property type="nucleotide sequence ID" value="NM_001381517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLF8"/>
    <dbReference type="GeneID" id="174306"/>
    <dbReference type="AGR" id="WB:WBGene00006832"/>
    <dbReference type="CTD" id="174306"/>
    <dbReference type="WormBase" id="C41C4.5d">
        <property type="protein sequence ID" value="CE46902"/>
        <property type="gene ID" value="WBGene00006832"/>
        <property type="gene designation" value="unc-105"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006832">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLF8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.470.10:FF:000004">
        <property type="entry name" value="Degenerin unc-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004726">
        <property type="entry name" value="Deg-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00867">
        <property type="entry name" value="deg-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF279">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN UNC-105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="748"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="842"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="907"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCF23432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="C41C4.5d"/>
        </source>
    </evidence>
    <sequence length="935" mass="105748" checksum="3E9E4C16E115DCA4" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>H2FLF9</accession>
    <name>H2FLF9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Degenerin-like protein unc-105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">unc-105</name>
        <name evidence="18" type="ORF">C41C4.5</name>
        <name evidence="16" type="ORF">CELE_C41C4.5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCF23433.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001364812.1">
        <property type="nucleotide sequence ID" value="NM_001377828.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2FLF9"/>
    <dbReference type="GeneID" id="174306"/>
    <dbReference type="AGR" id="WB:WBGene00006832"/>
    <dbReference type="CTD" id="174306"/>
    <dbReference type="WormBase" id="C41C4.5e">
        <property type="protein sequence ID" value="CE53921"/>
        <property type="gene ID" value="WBGene00006832"/>
        <property type="gene designation" value="unc-105"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="PhylomeDB" id="H2FLF9"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006832">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2FLF9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.470.10:FF:000004">
        <property type="entry name" value="Degenerin unc-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004726">
        <property type="entry name" value="Deg-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00867">
        <property type="entry name" value="deg-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF279">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN UNC-105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="748"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="842"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="908"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="932"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCF23433.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="C41C4.5e"/>
        </source>
    </evidence>
    <sequence length="974" mass="110033" checksum="A1831D28F68A4A02" modified="2020-04-22" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>K8F7Q8</accession>
    <name>K8F7Q8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">twk-13</name>
        <name evidence="13" type="ORF">CELE_R04F11.4</name>
        <name evidence="15" type="ORF">R04F11.4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCO25586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263869.1">
        <property type="nucleotide sequence ID" value="NM_001276940.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K8F7Q8"/>
    <dbReference type="GeneID" id="192077"/>
    <dbReference type="AGR" id="WB:WBGene00006668"/>
    <dbReference type="CTD" id="192077"/>
    <dbReference type="WormBase" id="R04F11.4d">
        <property type="protein sequence ID" value="CE47888"/>
        <property type="gene ID" value="WBGene00006668"/>
        <property type="gene designation" value="twk-13"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006668">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="K8F7Q8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF107">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="370"/>
            <end position="439"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCO25586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="R04F11.4d"/>
        </source>
    </evidence>
    <sequence length="590" mass="68193" checksum="8A9AE46008E4F7E1" modified="2013-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>K8F7R9</accession>
    <name>K8F7R9_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
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        <name evidence="7 9" type="primary">frpr-5</name>
        <name evidence="9" type="ORF">C56A3.3</name>
        <name evidence="7" type="ORF">CELE_C56A3.3</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCO25596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="K8F7R9"/>
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    <dbReference type="GeneID" id="183856"/>
    <dbReference type="AGR" id="WB:WBGene00008342"/>
    <dbReference type="CTD" id="183856"/>
    <dbReference type="WormBase" id="C56A3.3d">
        <property type="protein sequence ID" value="CE43071"/>
        <property type="gene ID" value="WBGene00008342"/>
        <property type="gene designation" value="frpr-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="K8F7R9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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    </dbReference>
    <dbReference type="GO" id="GO:0004930">
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="GPCR1-like"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="51"/>
            <end position="76"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="109"/>
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            <end position="247"/>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="68"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCO25596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C56A3.3d"/>
        </source>
    </evidence>
    <sequence length="489" mass="55668" checksum="3DA8F9A3B4F71AB1" modified="2013-02-06" version="1">MNRTATILEGMIPLIPDIMILEWEGSENSTECLCSDIQRDDYSPFFEWANYLTIILALPVLSVFGVLTNIINVFLYTRKRLQNSANTYLLFLACSDFMVIVTGLFIFWIDSARSYIPELTQAPYTTVYTLPFGYMAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNLRKCFNDITKEQVIEICPTSLFVTINSVYNIYMYMVLMTLLPFFFLLCINAIIVKRQSKAKTDESAPKNEGTSDDTITMIMVVILFLACNTLALVVNFIENFTEPSPVLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVFLIYWKKLKRVLIEEYCCCCVPAGSRNYSAYQPVSTRLVIEKSQNGSSSTKLILPSLDLNRSDQASFAESESAASPIWQPLTTRNLPNVDWPNIDDDIDSGWDDGSQISSRTPKRWLAEVNIVDVESSNGRHPRIYVRPLNQLPNNETISITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>K8F7T2</accession>
    <name>K8F7T2_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Protein roadkill</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">mel-26</name>
        <name evidence="3" type="ORF">CELE_ZK858.4</name>
        <name evidence="5" type="ORF">ZK858.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-11465240">
            <id>K8F7T2</id>
        </interactant>
        <interactant intactId="EBI-317307">
            <id>H2KYX3</id>
            <label>nfm-1</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCO25606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263463.1">
        <property type="nucleotide sequence ID" value="NM_001276534.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K8F7T2"/>
    <dbReference type="SMR" id="K8F7T2"/>
    <dbReference type="IntAct" id="K8F7T2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="K8F7T2"/>
    <dbReference type="GeneID" id="172737"/>
    <dbReference type="AGR" id="WB:WBGene00003209"/>
    <dbReference type="CTD" id="172737"/>
    <dbReference type="WormBase" id="ZK858.4b">
        <property type="protein sequence ID" value="CE48036"/>
        <property type="gene ID" value="WBGene00003209"/>
        <property type="gene designation" value="mel-26"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044770_0_0_1"/>
    <dbReference type="OMA" id="SWTVKNF"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="PhylomeDB" id="K8F7T2"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003209">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="K8F7T2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Protein maternal effect lethal 26"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Speckle-type POZ protein B"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
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        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="41"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="201"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCO25606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="ZK858.4b"/>
        </source>
    </evidence>
    <sequence length="399" mass="44933" checksum="5DDFFD224E5CC803" modified="2013-02-06" version="1">MEPRIDGGVFIGGIGNSGNEMCSNGVPALGVSSQTEIKVEKVQHTWTVKNFSHCYQEYLENFVYLQRGDEQLTWSIKIYPKGNGENNKDFVFLCLNRVINNNVKAGKIGFKSQFKLRTAENKDIEMRIHPNPSHSDYVSYIKRDVLFPQIMPRDMIIVNVEIDVAVETITTTNEPIQFEPTNSEQQLIEDYQRLFSQELLCDFAINVNGKIIRAHKAVLAARSPVFNAMLTHQDTDEAKSSMMYINDMDYDVIYEMVYYIYCGRCNKDITDMATALLIAADKYRLEELKSHCEKYLVENINIENACSLLIIGDLYSAPKLRKRAVTSLLQYILARPKNVTGTPGWEDILKGHPNLITDIFSQIDRQSSTGATSSVSNLPGVPMDIPGITGNIVPPPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>O44517</accession>
    <name>O44517_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F56A11.5</name>
        <name evidence="3 5" type="ORF">F56A11.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD65259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T32646">
        <property type="entry name" value="T32646"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_499948.1">
        <property type="nucleotide sequence ID" value="NM_067547.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O44517"/>
    <dbReference type="SMR" id="O44517"/>
    <dbReference type="DIP" id="DIP-24667N"/>
    <dbReference type="IntAct" id="O44517">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="O44517"/>
    <dbReference type="GeneID" id="176883"/>
    <dbReference type="UCSC" id="F56A11.5">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018925"/>
    <dbReference type="CTD" id="176883"/>
    <dbReference type="WormBase" id="F56A11.5a">
        <property type="protein sequence ID" value="CE17120"/>
        <property type="gene ID" value="WBGene00018925"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_6_1_1"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="PhylomeDB" id="O44517"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018925">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O44517">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052716">
        <property type="entry name" value="MOSC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36930">
        <property type="entry name" value="METAL-SULFUR CLUSTER BIOSYNTHESIS PROTEINS YUAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36930:SF1">
        <property type="entry name" value="MOSC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="185"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD65259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F56A11.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="O44517"/>
        </source>
    </evidence>
    <sequence length="340" mass="38772" checksum="3EB1F3E919923E8A" modified="1998-06-01" version="1">MNTLYEDRKVIFGILGTSFFSWTAFLALKGLVKKYSKPKAEWVPVGRIKSLHLYPIKSCKGKEVFQYRCTPFGPRLGEYLDRHFLVINSDGKFYTARTKPQMVLIETLIKDGIVRVSYPGREDAQFKIEDVKANKDLRSGFLHVDLRTDGYDCGDAVAEFFSNVLEEPGTRVIMYDTGLFTERTCKTEEGWWNNEVPKRIDDTAYADLAPYMITSQASLDDLNSKLDQNVSSINFRPCIVVDDCAAWDEDKWLDLRIGDVEMQCFKPCTRCILTTVNPETGTKDKDMQPLKKLREFRLGPGKLRQEFGESPIFGVNAGLVKTGYIHVGQTVWAKYKPSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2025-10-08" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>O45812</accession>
    <name>O45812_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuolar protein sorting-associated protein VTA1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CELE_T23G11.7</name>
        <name evidence="12 14" type="ORF">T23G11.7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB03419.4"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T25195">
        <property type="entry name" value="T25195"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_492139.3">
        <property type="nucleotide sequence ID" value="NM_059738.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O45812"/>
    <dbReference type="SMR" id="O45812"/>
    <dbReference type="IntAct" id="O45812">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="O45812"/>
    <dbReference type="GeneID" id="172528"/>
    <dbReference type="UCSC" id="T23G11.7b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011972"/>
    <dbReference type="CTD" id="172528"/>
    <dbReference type="WormBase" id="T23G11.7b">
        <property type="protein sequence ID" value="CE41267"/>
        <property type="gene ID" value="WBGene00011972"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030378_1_0_1"/>
    <dbReference type="OMA" id="AYWCEYH"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011972">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O45812">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="274"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAB03419.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T23G11.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="O45812"/>
        </source>
    </evidence>
    <sequence length="312" mass="34472" checksum="76558A36CF95C2BE" modified="2007-07-10" version="4">MSANLPPAFKPIAHYIKIANENASRDPVIYYWCLFYAVQTAMKLDKSTVEARQYLTGLLTTLEAIKTQLADNDAIKNETIAQAHIESFAEKLFNFADKKEKTGNVDKSVVHAFYTAGHVMDILSLFGEIDEPFLSSKKYAKWKSTQIFTCLRDGTPYVPSSQETEDADDDLSQFGAQFQPNAPSSSGPQEHSYNQPPAPGFGFGGGIPNVPSDHSLPPQPPARNNIPPPSYSSTPNLPSHTPFSAPPPRNQPQQYEDFSTPQPVAPPGSVPTDEEFAEVRKLTKYAMSAVDYEDVKAIRDNLIKALTILQKY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2026-01-28" version="214" xmlns="https://uniprot.org/uniprot">
    <accession>P17139-2</accession>
    <name>CO4A1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Collagen alpha-1(IV) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">emb-9</name>
        <name evidence="1" type="synonym">clb-2</name>
        <name evidence="1" type="ORF">K04H4.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1989" name="J. Biol. Chem." volume="264" first="17574" last="17582">
            <title>The two Caenorhabditis elegans basement membrane (type IV) collagen genes are located on separate chromosomes.</title>
            <authorList>
                <person name="Guo X."/>
                <person name="Kramer J.M."/>
            </authorList>
            <dbReference type="PubMed" id="2793871"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1447-1759 (ISOFORMS A/B)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1991" name="Nature" volume="349" first="707" last="709">
            <title>Embryonic lethality caused by mutations in basement membrane collagen of C. elegans.</title>
            <authorList>
                <person name="Guo X."/>
                <person name="Johnson J.J."/>
                <person name="Kramer J.M."/>
            </authorList>
            <dbReference type="PubMed" id="1996137"/>
            <dbReference type="DOI" id="10.1038/349707a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
        <scope>MUTAGENESIS OF GLY-403 AND GLY-409</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="J. Neurosci." volume="34" first="10311" last="10324">
            <title>Perlecan antagonizes collagen IV and ADAMTS9/GON-1 in restricting the growth of presynaptic boutons.</title>
            <authorList>
                <person name="Qin J."/>
                <person name="Liang J."/>
                <person name="Ding M."/>
            </authorList>
            <dbReference type="PubMed" id="25080592"/>
            <dbReference type="DOI" id="10.1523/JNEUROSCI.5128-13.2014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-213 AND GLY-258</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006475" last="E1006475">
            <title>The C. elegans discoidin domain receptor DDR-2 modulates the Met-like RTK-JNK signaling pathway in axon regeneration.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Nagamori Y."/>
                <person name="Shimizu T."/>
                <person name="Pastuhov S.I."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="27984580"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006475"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2018" name="Genetics" volume="208" first="1499" last="1512">
            <title>Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes.</title>
            <authorList>
                <person name="Gotenstein J.R."/>
                <person name="Koo C.C."/>
                <person name="Ho T.W."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="29440357"/>
            <dbReference type="DOI" id="10.1534/genetics.118.300731"/>
        </citation>
        <scope>MUTAGENESIS OF PRO-141 AND GLY-213</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P17139-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P17139-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_011573"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022663.1">
        <property type="nucleotide sequence ID" value="NM_001027492.6"/>
    </dbReference>
    <dbReference type="WormBase" id="K04H4.1b">
        <property type="protein sequence ID" value="CE36390"/>
        <property type="gene ID" value="WBGene00001263"/>
        <property type="gene designation" value="emb-9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
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    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="K04H4.1a"/>
        </source>
    </evidence>
    <sequence length="1502" mass="146687" checksum="021478C18F992F52" modified="2013-07-24" version="5" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>P34424-2</accession>
    <name>CCNT2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Cyclin-T1.2</fullName>
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    <gene>
        <name type="primary">cit-1.2</name>
        <name type="ORF">F44B9.3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34424-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34424-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_015982"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001370391.1">
        <property type="nucleotide sequence ID" value="NM_001382929.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F44B9.3b">
        <property type="protein sequence ID" value="CE32417"/>
        <property type="gene ID" value="WBGene00000508"/>
        <property type="gene designation" value="cit-1.2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="381" mass="42936" checksum="0B8C9AE5F9B154C4" modified="2002-06-06" version="2">MRDVEKGRNVYKDMVKTAYYMATDVLIITDWSVRYSCASIATACVNIAAFFHNINMDDIVPFELSDRWYRLEDQSMTREEVEAMTKEFLDIFSRNPQFHIGSLKKIDPLGKVKIVGMPPQVSSTVTPSGSSSNLKKIDLESYKGRPKPLSNSSDSPSTRPSFLPDVKNQKVVEQELMEQRMKEAAQQKIHRNGHRPSSSSHPLHHHSTSSSASNNSNHQNRSSSGLSAHQHQKPYNEDSRSAKRSMMYEETNSSKKPRIDYKMSFVASSSTTIATMHNDHFSQTTHQQNISTYARGVNEMMLNQVAPPPLMSVSAQPSTYQKMCMEYQRNPADSRHTMSSTQQISPPDEPSPPVSQILLPPPPPPPILPPRLDEMEEGELV</sequence>
</entry>
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    <accession>P34437-2</accession>
    <name>YL57_CAEEL</name>
    <protein>
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            <fullName>Isoform b of Putative zinc finger protein F44E2.7</fullName>
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    <gene>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34437-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_015937 VSP_015938"/>
        </isoform>
        <isoform>
            <id>P34437-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34437-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_015939"/>
        </isoform>
        <isoform>
            <id>P34437-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_015936"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367856.1">
        <property type="nucleotide sequence ID" value="NM_001379851.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F44E2.7b">
        <property type="protein sequence ID" value="CE30994"/>
        <property type="gene ID" value="WBGene00018420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="379" mass="44408" checksum="A5D71BF54ED9B014" modified="2002-06-06" version="2">MSRESRNRNSDDDYYDYVYEDEKPKRRRIDVEQSRRSVAAAAEKHRKLLEEQRRKAEAEYERKRKADEKKKEKAIKDEEKRKAEDLRKCLQLQQQKTAAAAQIRETAEKAAVARRMSTFEVGESSEQLAKPEGEKRKRRRTESRWREIESDSDKPEVTALVKKILEESKKKEASSQEVEDADLVPELSTRKPYDNTEHVSKLCKVCKKGPHYTFANLFEHYQDLHNATIKSLHYYGFNGNKLIGKKNLIERDHCQRCVIKFPRARDYFAHMIKHHVYESVRCQLDFENATNADVEARMMFRDRILTLGYNFKFEQVADPNLVSDVLEPGQEPSTSAEQEDPSSLKIVKLEEPELEEQKALKPESEAMEQQEDVHSLNPE</sequence>
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<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>P34437-3</accession>
    <name>YL57_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Putative zinc finger protein F44E2.7</fullName>
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    <gene>
        <name type="ORF">F44E2.7</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34437-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34437-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_015937 VSP_015938"/>
        </isoform>
        <isoform>
            <id>P34437-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_015936"/>
        </isoform>
        <isoform>
            <id>P34437-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_015939"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741257.1">
        <property type="nucleotide sequence ID" value="NM_171219.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F44E2.7c">
        <property type="protein sequence ID" value="CE30995"/>
        <property type="gene ID" value="WBGene00018420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="411" mass="48013" checksum="B6936C3D47E88CA3" modified="2002-06-06" version="2">MWKKTEQNRQMIQGTAHRPDEGSEILSVPASPMSRESRNRNSDDDYYDYVYEDEKPKRRRIDVEQSRRSVAAAAEKHRKLLEEQRRKAEAEYERKRKADEKKKEKAIKDEEKRKAEDLRKCLQLQQQKTAAAAQIRETAEKAAVARRMSTFEVGESSEQLAKPEGEKRKRRRTESRWREIESDSDKPEVTALVKKILEESKKKEASSQEVEDADLVPELSTRKPYDNTEHVSKLCKVCKKGPHYTFANLFEHYQDLHNATIKSLHYYGFNGNKLIGKKNLIERDHCQRCVIKFPRARDYFAHMIKHHVYESVRCQLDFENATNADVEARMMFRDRILTLGYNFKFEQVADPNLVSDVLEPGQEPSTSAEQEDPSSLKIVKLEEPELEEQKALKPESEAMEQQEDVHSLNPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>P34437-4</accession>
    <name>YL57_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform d of Putative zinc finger protein F44E2.7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">F44E2.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34437-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34437-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_015939"/>
        </isoform>
        <isoform>
            <id>P34437-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_015936"/>
        </isoform>
        <isoform>
            <id>P34437-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_015938 VSP_015937"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022588.1">
        <property type="nucleotide sequence ID" value="NM_001027417.6"/>
    </dbReference>
    <dbReference type="WormBase" id="F44E2.7d">
        <property type="protein sequence ID" value="CE24975"/>
        <property type="gene ID" value="WBGene00018420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="469" mass="54954" checksum="0562DB0BC0463F94" modified="2002-06-06" version="2">MVKPTSSLLQRYKNNVRVDPSTLNHYLCYYCGKTLSDRLEYQQHMLKVHEVMSQSYQLWSDHTMDTLGLIWSESKRSYDRDTSCSLPASPMSRESRNRNSDDDYYDYVYEDEKPKRRRIDVEQSRRSVAAAAEKHRKLLEEQRRKAEAEYERKRKADEKKKEKAIKDEEKRKAEDLRKCLQLQQQKTAAAAQIRETAEKAAVARRMSTFEVGESSEQLAKPEGEKRKRRRTESRWREIESDSDKPEVTALVKKILEESKKKEASSQEVEDADLVPELSTRKPYDNTEHVSKLCKVCKKGPHYTFANLFEHYQDLHNATIKSLHYYGFNGNKLIGKKNLIERDHCQRCVIKFPRARDYFAHMIKHHVYESVRCQLDFENATNADVEARMMFRDRILTLGYNFKFEQVADPNLVSDVLEPGQEPSTSAEQEDPSSLKIVKLEEPELEEQKALKPESEAMEQQEDVHSLNPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>P53439-2</accession>
    <name>CDSA_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Phosphatidate cytidylyltransferase</fullName>
            <ecNumber>2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>CDP-DAG synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>CDP-DG synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>CDP-diacylglycerol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>CDP-diglyceride pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>CDP-diglyceride synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">cdgs-1</name>
        <name type="ORF">C33H5.18</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2014" name="Genes Dev." volume="28" first="121" last="126">
            <title>Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown.</title>
            <authorList>
                <person name="Bahmanyar S."/>
                <person name="Biggs R."/>
                <person name="Schuh A.L."/>
                <person name="Desai A."/>
                <person name="Muller-Reichert T."/>
                <person name="Audhya A."/>
                <person name="Dixon J.E."/>
                <person name="Oegema K."/>
            </authorList>
            <dbReference type="PubMed" id="24449268"/>
            <dbReference type="DOI" id="10.1101/gad.230599.113"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P53439-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_055417"/>
        </isoform>
        <isoform>
            <id>P53439-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.7.41"/>
    <dbReference type="RefSeq" id="NP_501297.1">
        <property type="nucleotide sequence ID" value="NM_068896.7"/>
    </dbReference>
    <dbReference type="WormBase" id="C33H5.18a">
        <property type="protein sequence ID" value="CE04161"/>
        <property type="gene ID" value="WBGene00016384"/>
        <property type="gene designation" value="cdgs-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="455" mass="52442" checksum="ECD8048CA0A28649" modified="2014-09-03" version="2">MSDQPPAENADVRQRRAPESPVTERLRAPARDDARPTSDESDMEGILQDEDRLERLTQAIPQDKGSLGVFADSMLEALPPRWRNWVVRGLFSIIMISTFTFIVTRGATWLMFLVFLIQFKCFQEIISIGLAVYRLYDFPWFRALSWYFLLTSNYFFFGESLIDYWGIVLKKDNFLHFLVAYHRLVSFALYCIGFVSFVLSLRKGYYMRQFSLFAWTHLTLLLIVSQSFFIIQNIFQGLIWFLAPVAMIICCDIMSYMFGFFWGKTPLIKLSPKKTWEGFIGGAFSTVVFGILLSLALYNRPFFVCPVQHYQTDSSNCTIPLAFQLQDYPVPRPFSFVYKILRKEPIIQLCPFVFHSIALSLFASILGPFGGFFASGFKRAFKIKDFGDVIPGHGGLMDRFDCQLLMGTFVMVYIHSFIRVPDASKLLKQIMTLEPQDQLNIFNLLQSELSKTGLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q18936-2</accession>
    <name>TPRA1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Transmembrane protein adipocyte-associated 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tpra-1</name>
        <name type="ORF">D1046.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-45</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q18936-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q18936-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_053715"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255358.1">
        <property type="nucleotide sequence ID" value="NM_001268429.3"/>
    </dbReference>
    <dbReference type="WormBase" id="D1046.5b">
        <property type="protein sequence ID" value="CE44691"/>
        <property type="gene ID" value="WBGene00008366"/>
        <property type="gene designation" value="tpra-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="63" mass="6784" checksum="498B696E129A8E43" modified="2003-03-01" version="2">MTSVETAESTVTTRTGSDDYAHHRDSMLSEPSTGTTTRHLKGLGPQGSLVFEDDPSSLTSLRM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2026-01-28" version="180" xmlns="https://uniprot.org/uniprot">
    <accession>Q19345-2</accession>
    <name>NHR25_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Nuclear hormone receptor family member nhr-25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nhr-25</name>
        <name evidence="3" type="ORF">F11C1.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Dev. Biol." volume="221" first="259" last="272">
            <title>nhr-25, the Caenorhabditis elegans ortholog of ftz-f1, is required for epidermal and somatic gonad development.</title>
            <authorList>
                <person name="Gissendanner C.R."/>
                <person name="Sluder A.E."/>
            </authorList>
            <dbReference type="PubMed" id="10772806"/>
            <dbReference type="DOI" id="10.1006/dbio.2000.9679"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Mol. Cell. Biol." volume="24" first="7345" last="7358">
            <title>The Caenorhabditis elegans nuclear receptor gene nhr-25 regulates epidermal cell development.</title>
            <authorList>
                <person name="Chen Z."/>
                <person name="Eastburn D.J."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="15314147"/>
            <dbReference type="DOI" id="10.1128/mcb.24.17.7345-7358.2004"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH NOB-1 AND LIN-39</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF LEU-32</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002010" last="E1002010">
            <title>A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Nelson M.D."/>
                <person name="Zhou E."/>
                <person name="Kiontke K."/>
                <person name="Fradin H."/>
                <person name="Maldonado G."/>
                <person name="Martin D."/>
                <person name="Shah K."/>
                <person name="Fitch D.H."/>
            </authorList>
            <dbReference type="PubMed" id="21408209"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF LEU-32</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="7441" last="7441">
            <title>Probiotic Lactobacillus fermentum strain JDFM216 stimulates the longevity and immune response of Caenorhabditis elegans through a nuclear hormone receptor.</title>
            <authorList>
                <person name="Park M.R."/>
                <person name="Ryu S."/>
                <person name="Maburutse B.E."/>
                <person name="Oh N.S."/>
                <person name="Kim S.H."/>
                <person name="Oh S."/>
                <person name="Jeong S.Y."/>
                <person name="Jeong D.Y."/>
                <person name="Oh S."/>
                <person name="Kim Y."/>
            </authorList>
            <dbReference type="PubMed" id="29748542"/>
            <dbReference type="DOI" id="10.1038/s41598-018-25333-8"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19345-2</id>
            <name evidence="3">b</name>
            <name evidence="1">Beta</name>
            <sequence type="described" ref="VSP_003723"/>
        </isoform>
        <isoform>
            <id>Q19345-1</id>
            <name evidence="2">a</name>
            <name evidence="1">Alpha</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024551.1">
        <property type="nucleotide sequence ID" value="NM_001029380.8"/>
    </dbReference>
    <dbReference type="WormBase" id="F11C1.6b">
        <property type="protein sequence ID" value="CE35856"/>
        <property type="gene ID" value="WBGene00003623"/>
        <property type="gene designation" value="nhr-25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="10772806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F11C1.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F11C1.6b"/>
        </source>
    </evidence>
    <sequence length="492" mass="55521" checksum="666A99A41C0E2404" modified="1996-11-01" version="1">MGMKMEAVRADRMRGGRNKFGSFYKKDRAHRMQRNAMRVSTVQVPAVLGAQSQAQTFYQPPEHQVSSSTTDQNNQINYFDQTKIKTEYIKTEYDAHLQSPTLSSSTNQQLSVSDFIMRPGYLVDPQDSLAVLLGSTIDDPLLRHTFPAAYQLNEVKQEPFDYSEQFIHHSLHDYPTYTSNTTNYATMMPMTTVSSTQSLVTSTSSTTTGRMTEASSTSPILPLCPAPTEKTVDHFYNSSIAEMCKTLPDDAQIARIFTSVKGTSKPEKHAFSIQVAEENLKDIVIWAKNDQLFSKLSLDDQMILLQTSWTTVHIVDITNAMVHGNLLSQYKMSNGDEVPVGLVALLGNQTFVSSWNDVVIRLRNMGFTNFDYCAFRFLALFDQSMDSFPAVSTARSRVLQSWREVRCTTAFLEIFEQIRRLAYDSLRYLWNLHSNCPTNWEQFFPEASLVLEMIRTTVNRSASSSVTAITQVPAIQLPTPQATYTAVPYMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q19814</accession>
    <name>Q19814_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srh-76</name>
        <name evidence="2" type="ORF">CELE_F26F12.6</name>
        <name evidence="4" type="ORF">F26F12.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD62683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34240">
        <property type="entry name" value="T34240"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023859.1">
        <property type="nucleotide sequence ID" value="NM_001028688.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19814"/>
    <dbReference type="GeneID" id="191870"/>
    <dbReference type="KEGG" id="cel:CELE_F26F12.6"/>
    <dbReference type="UCSC" id="F26F12.6b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00005297"/>
    <dbReference type="CTD" id="191870"/>
    <dbReference type="WormBase" id="F26F12.6a">
        <property type="protein sequence ID" value="CE36930"/>
        <property type="gene ID" value="WBGene00005297"/>
        <property type="gene designation" value="srh-76"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2544653_0_0_1"/>
    <dbReference type="OrthoDB" id="5855033at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019422">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10318">
        <property type="entry name" value="7TM_GPCR_Srh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD62683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F26F12.6a"/>
        </source>
    </evidence>
    <sequence length="83" mass="9382" checksum="7BBD391737BD50CB" modified="2004-10-11" version="3">MCLQSLLTSTLLTPITWLPTIGSSMMGLFSYIGVPETVQFYLFVIVMFVTMSSVVSPFENRHNAIQHNTLRISTSWFSDSIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q20813</accession>
    <name>Q20813_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FIP-RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rfip-1</name>
        <name evidence="11" type="ORF">CELE_F55C12.1</name>
        <name evidence="13" type="ORF">F55C12.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD71868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34311">
        <property type="entry name" value="T34311"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367895.1">
        <property type="nucleotide sequence ID" value="NM_001381439.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q20813"/>
    <dbReference type="SMR" id="Q20813"/>
    <dbReference type="DIP" id="DIP-26087N"/>
    <dbReference type="PeptideAtlas" id="Q20813"/>
    <dbReference type="GeneID" id="173998"/>
    <dbReference type="UCSC" id="F55C12.1d.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018869"/>
    <dbReference type="CTD" id="173998"/>
    <dbReference type="WormBase" id="F55C12.1a">
        <property type="protein sequence ID" value="CE02770"/>
        <property type="gene ID" value="WBGene00018869"/>
        <property type="gene designation" value="rfip-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018925_0_0_1"/>
    <dbReference type="OrthoDB" id="418358at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018869">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q20813">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2440:FF:000007">
        <property type="entry name" value="Rab-11 Family Interacting-Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057316">
        <property type="entry name" value="Rab11-FIP3/4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051977">
        <property type="entry name" value="Rab11-interacting_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726:SF7">
        <property type="entry name" value="NUCLEAR FALLOUT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726">
        <property type="entry name" value="RAB11-FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25450">
        <property type="entry name" value="Rab11-FIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FIP-RBD" evidence="10">
        <location>
            <begin position="269"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="56"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="138"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD71868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F55C12.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q20813"/>
        </source>
    </evidence>
    <sequence length="454" mass="52012" checksum="27441E395B4A7D6F" modified="1996-11-01" version="1">MRLQGSSASSASVASRLYGTRSRRDSLGGSSSESDLIAFGGDQDALNDFSSQMNQLNSFTKRYSELEERNMSLSDERTRLKTENSVLKERMHNLEEQLTDNEDRFKQLLSDEKARGTESMSRLKREKELETESWNLKYQMLEKDLISVKKDAERSNEETKRIRNELEKTENKLEEAQLLVEGMEEERIQLERQFRKFKEEAQQDIDSSSEMVEVLALETEELRRKVDGPRSESISDREDMHEEIEILKAKVAELMKEKEEMTDQLLATSVERGRSLIADTPSLADELAGGDSSQLLDALREQEICNQKLRVYINGILMRVIERHPEILEIGEEGILSKLTVRRRISVLANVVVIIDSRRVIITDTFSKNLRLPSLIVSSMGMNRHMTSSTIGTQFLVTWHATFSLFFSFLHPCDFQNALLQMFLCTISSFLVPFTPSNSIFELRATSQIDPVNG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="169" xmlns="https://uniprot.org/uniprot">
    <accession>Q22744-2</accession>
    <name>RASF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform b of Ras association domain-containing protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 6" type="primary">rsf-1</name>
        <name evidence="2 6" type="synonym">rasf-1</name>
        <name evidence="6" type="ORF">T24F1.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="Exp. Cell Res." volume="319" first="1" last="11">
            <title>Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1.</title>
            <authorList>
                <person name="Iwasa H."/>
                <person name="Kuroyanagi H."/>
                <person name="Maimaiti S."/>
                <person name="Ikeda M."/>
                <person name="Nakagawa K."/>
                <person name="Hata Y."/>
            </authorList>
            <dbReference type="PubMed" id="23103556"/>
            <dbReference type="DOI" id="10.1016/j.yexcr.2012.10.008"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CST-1</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2013" name="Genes Cells" volume="18" first="203" last="210">
            <title>C. elegans Rassf homolog, rasf-1, is functionally associated with rab-39 Rab GTPase in oxidative stress response.</title>
            <authorList>
                <person name="Takenaka M."/>
                <person name="Inoue H."/>
                <person name="Takeshima A."/>
                <person name="Kakura T."/>
                <person name="Hori T."/>
            </authorList>
            <dbReference type="PubMed" id="23294242"/>
            <dbReference type="DOI" id="10.1111/gtc.12028"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH RAB-39</scope>
        <scope>TISSUE SPECIFICITY (ISOFORM A)</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q22744-1</id>
            <name evidence="6">a</name>
            <name evidence="2">rasf-1a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q22744-2</id>
            <name evidence="7">b</name>
            <name evidence="2">rasf-1b</name>
            <sequence type="described" ref="VSP_061059"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001370200.1">
        <property type="nucleotide sequence ID" value="NM_001383950.2"/>
    </dbReference>
    <dbReference type="WormBase" id="T24F1.3b">
        <property type="protein sequence ID" value="CE38227"/>
        <property type="gene ID" value="WBGene00011995"/>
        <property type="gene designation" value="rsf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="23103556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="23294242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="23103556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T24F1.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T24F1.3b"/>
        </source>
    </evidence>
    <sequence length="554" mass="62276" checksum="DF05C9861FA6F365" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q2EEM2</accession>
    <name>Q2EEM2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y41E3.7</name>
        <name evidence="4 6" type="ORF">Y41E3.7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041027.1">
        <property type="nucleotide sequence ID" value="NM_001047562.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2EEM2"/>
    <dbReference type="SMR" id="Q2EEM2"/>
    <dbReference type="PeptideAtlas" id="Q2EEM2"/>
    <dbReference type="GeneID" id="178416"/>
    <dbReference type="UCSC" id="Y41E3.7a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012765"/>
    <dbReference type="CTD" id="178416"/>
    <dbReference type="WormBase" id="Y41E3.7c">
        <property type="protein sequence ID" value="CE18375"/>
        <property type="gene ID" value="WBGene00012765"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048443_0_0_1"/>
    <dbReference type="OrthoDB" id="5839451at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012765">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2EEM2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.680:FF:000006">
        <property type="entry name" value="Acyl-CoA binding domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.680:FF:000011">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052269">
        <property type="entry name" value="Golgi-PI4KB_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973:SF12">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13897">
        <property type="entry name" value="GOLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="173"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ76976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y41E3.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q2EEM2"/>
        </source>
    </evidence>
    <sequence length="338" mass="38282" checksum="DB8D46B14449073A" modified="2006-03-21" version="1">MASFVFLVDRVCPPFKGFIADKKAIKDAELKEFAPQVTEQSAQPPSLQQVDQRLFEDQRKQIQEALNAQTFHQFSAYAQEQFPGQPEQQTTLIRQLQEQHYQQYMSQVYAQQSTTPNGAEMNPEESHQHQIRRDDDSDVSDDEAGEDLPSNPAISPASLWNRQDINEFKANIKKDGHEGIIKVGHGETVTVRVPTHENGSCLFWEFATDHYDIGFGVYFEWTVADSNQVSVHVSESDDEEDYDEALEAEQAEAGGGGGGAAGQGGPGDVEAGAMQTRRVDPNKPRQDEIIPVYRRDCHEEVYAGSHRYPGRGIYLLKFDNSYSLWRSKTLYYRVYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2EEM4</accession>
    <name>Q2EEM4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PRotein arginine MethylTransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">prmt-9</name>
        <name evidence="3" type="synonym">prmt-3</name>
        <name evidence="1" type="ORF">CELE_T23B5.1</name>
        <name evidence="3" type="ORF">T23B5.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040991.1">
        <property type="nucleotide sequence ID" value="NM_001047526.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2EEM4"/>
    <dbReference type="PeptideAtlas" id="Q2EEM4"/>
    <dbReference type="GeneID" id="178221"/>
    <dbReference type="UCSC" id="T23B5.1a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011939"/>
    <dbReference type="CTD" id="178221"/>
    <dbReference type="WormBase" id="T23B5.1b">
        <property type="protein sequence ID" value="CE39779"/>
        <property type="gene ID" value="WBGene00011939"/>
        <property type="gene designation" value="prmt-9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402386_0_0_1"/>
    <dbReference type="OrthoDB" id="5980806at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011939">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2EEM4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ76953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T23B5.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="Q2EEM4"/>
        </source>
    </evidence>
    <sequence length="347" mass="40049" checksum="B1E1E614AD866F36" modified="2006-03-21" version="1">MHSVDFSSIANLKDSLANSNSFKIRPAKDGVAHGFSVHFTSDLTGHGDNIIDSSKSRAWDLGIIPFKEPCLVKCDKEYEGSWKLLNNRLDVYNDFYDENLQKHEDSLRYETASLDQLQKIRDDSYFKAMMGEIDPIELPFTRDISSSIPAQCVLNTVESQTPIRHLITNFCRYDGTLDQETFFRIEEFVGFRDHVQKIVPTKFRILGHLFYSDRVHFDARPDPSAHCQVDLSTVRSFNLREMRDIRLTQREDIVMASKEFVLYDFNISAEKFRQDTYITVTQDVTVQPTRPIADGVIYEFEILGIRNTKLRPVAAFLFPERVNTNPDMTVVFDLHLGEMLISLKDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q2EEM5</accession>
    <name>Q2EEM5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uso1_p115_head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">uso-1</name>
        <name evidence="12" type="ORF">CELE_K09B11.9</name>
        <name evidence="14" type="ORF">K09B11.9</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040974.1">
        <property type="nucleotide sequence ID" value="NM_001047509.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2EEM5"/>
    <dbReference type="SMR" id="Q2EEM5"/>
    <dbReference type="IntAct" id="Q2EEM5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="178311"/>
    <dbReference type="UCSC" id="K09B11.9a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010713"/>
    <dbReference type="CTD" id="178311"/>
    <dbReference type="WormBase" id="K09B11.9b">
        <property type="protein sequence ID" value="CE39750"/>
        <property type="gene ID" value="WBGene00010713"/>
        <property type="gene designation" value="uso-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006318_2_0_1"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010713">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2EEM5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041209">
        <property type="entry name" value="P115_Arm_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18770">
        <property type="entry name" value="Arm_vescicular"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="10">
        <location>
            <begin position="346"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="11">
        <location>
            <begin position="748"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="645"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="753"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAJ76944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="K09B11.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q2EEM5"/>
        </source>
    </evidence>
    <sequence length="875" mass="99387" checksum="622C5AB56D2E17E1" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q2EEM6</accession>
    <name>Q2EEM6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CELE_K09B11.5</name>
        <name evidence="13 15" type="ORF">K09B11.5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040972.1">
        <property type="nucleotide sequence ID" value="NM_001047507.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2EEM6"/>
    <dbReference type="SMR" id="Q2EEM6"/>
    <dbReference type="IntAct" id="Q2EEM6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="178307"/>
    <dbReference type="UCSC" id="K09B11.5a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010712"/>
    <dbReference type="CTD" id="178307"/>
    <dbReference type="WormBase" id="K09B11.5b">
        <property type="protein sequence ID" value="CE39749"/>
        <property type="gene ID" value="WBGene00010712"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_7_2_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010712">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2EEM6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001700">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000832">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000108">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="117"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ76943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="K09B11.5b"/>
        </source>
    </evidence>
    <sequence length="525" mass="59167" checksum="849CF86069967C67" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2EEM9</accession>
    <name>Q2EEM9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">bus-12</name>
        <name evidence="6" type="ORF">CELE_JC8.12</name>
        <name evidence="8" type="ORF">JC8.12</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040958.1">
        <property type="nucleotide sequence ID" value="NM_001047493.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2EEM9"/>
    <dbReference type="SMR" id="Q2EEM9"/>
    <dbReference type="GeneID" id="178283"/>
    <dbReference type="UCSC" id="JC8.12a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010442"/>
    <dbReference type="CTD" id="178283"/>
    <dbReference type="WormBase" id="JC8.12b">
        <property type="protein sequence ID" value="CE39741"/>
        <property type="gene ID" value="WBGene00010442"/>
        <property type="gene designation" value="bus-12"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_875241_0_0_1"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010442">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2EEM9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAJ76931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="JC8.12b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q2EEM9"/>
        </source>
    </evidence>
    <sequence length="304" mass="34445" checksum="5E6A872B2C5ED232" modified="2006-03-21" version="1">MIVFVAASVFCSLMSKIMVTRYFFDYPVVILMMQSAATLFVIEVTRVLGILKVAPYCFEKGRHIVIPSILYTISQWITVASFEGIAMPNFDSVKRLTPILILVGLAARNRQQRVDQNKTFIIIGLSIASAFAVNLDLSVDRYSLMYGLVGAILQAAAFVLFEEHLQNYNYTEVLYMHSFNSLVFYLLADMVRDELRDAFMYMITSAHPLFIIVFAVSMFAGVLFHFTTFSCLEKNGPLNMQIVSNVRAVVETFLAYYLSVYLFYDVYPGVLNWAFLAVTFVAARALVNRDCEPEIVKGPWMSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q2EEN5</accession>
    <name>Q2EEN5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">vamp-8</name>
        <name evidence="7" type="ORF">B0513.9</name>
        <name evidence="5" type="ORF">CELE_B0513.9</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040905.1">
        <property type="nucleotide sequence ID" value="NM_001047440.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2EEN5"/>
    <dbReference type="SMR" id="Q2EEN5"/>
    <dbReference type="GeneID" id="178349"/>
    <dbReference type="UCSC" id="B0513.9b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007200"/>
    <dbReference type="CTD" id="178349"/>
    <dbReference type="WormBase" id="B0513.9b">
        <property type="protein sequence ID" value="CE39665"/>
        <property type="gene ID" value="WBGene00007200"/>
        <property type="gene designation" value="vamp-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_5_0_1"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007200">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000130">
        <property type="entry name" value="VAMP (Vesicle Associated Membrane Protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAJ76927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="B0513.9b"/>
        </source>
    </evidence>
    <sequence length="113" mass="13154" checksum="63FEB921916447F6" modified="2006-03-21" version="1">MENDSNKPSDNDQQKEKMQNLRNQVDSVKAVMVDNVERILERGERLDNIERRSEQLNATSANFKFTARKVQRKFCMLNAKWTVILSIVILIVFVVLLLLILHWTGVIGKRNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q2EEN7</accession>
    <name>Q2EEN7_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C48D1.1</name>
        <name evidence="2" type="ORF">CELE_C48D1.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76935.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040929.2">
        <property type="nucleotide sequence ID" value="NM_001047464.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2EEN7"/>
    <dbReference type="SMR" id="Q2EEN7"/>
    <dbReference type="GeneID" id="178271"/>
    <dbReference type="UCSC" id="C48D1.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008177"/>
    <dbReference type="CTD" id="178271"/>
    <dbReference type="WormBase" id="C48D1.1b">
        <property type="protein sequence ID" value="CE43624"/>
        <property type="gene ID" value="WBGene00008177"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022099_0_0_1"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008177">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2EEN7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056845">
        <property type="entry name" value="LRR_Zer-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF28">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25013">
        <property type="entry name" value="LRR_Zer-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zer-1-like leucine-rich repeats region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ76935.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C48D1.1b"/>
        </source>
    </evidence>
    <sequence length="497" mass="56654" checksum="FDDD362F586D788B" modified="2009-05-26" version="2">MKRWTAKIGNMLPSLTHLTMSDVHINEDDFYQLFGNFSNLRSLDISGTNILNIAGISRLKQLEVLALRDFSIATYTELKDLFNLKHLRVLDVSQTRFNLHSRNNIVEQFTECKMELPELRFMDCTRTSLSGDILECLLKTQRNLQLVTTIMTEAETSQYNDVRVLNTAYFHKSVQALVYCLTARKEFDSGYCMKAIRISISEDNLQNLNIPSCIKTIVKSMQTFDSISVTQNGLKCLIIFGMLYSNQLCSNGVTLLVEALMSFVYLYKRMISEAYVKVNISYWNAVEKLVNLKLGKLDFDKISKTAMSFLLENRVSKALRTRASSVLCQCIHRMHSDELKSLSEKTENVNRLVDILEWSVGQKNETKLSEFFEITIKMTEKSSKACTNMIQAGIISISLSCMEKVESNDITTKCLELLTNLSSALNYDSLQELYTSSNVDKIGLMLTRQKNDITFQTTSLLTKLLHHAEGNQVQYKLINQLLAESNRLAIGIDKIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-11-23" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ZR35</accession>
    <name>Q5ZR35_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">mec-1</name>
        <name evidence="9" type="ORF">CELE_T07H8.4</name>
        <name evidence="11" type="ORF">T07H8.4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD66558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024120.1">
        <property type="nucleotide sequence ID" value="NM_001028949.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q5ZR35"/>
    <dbReference type="GeneID" id="188259"/>
    <dbReference type="UCSC" id="T07H8.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003165"/>
    <dbReference type="CTD" id="188259"/>
    <dbReference type="WormBase" id="T07H8.4g">
        <property type="protein sequence ID" value="CE37674"/>
        <property type="gene ID" value="WBGene00003165"/>
        <property type="gene designation" value="mec-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003165">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q5ZR35">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043062">
        <property type="term" value="P:extracellular structure organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007638">
        <property type="term" value="P:mechanosensory behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009612">
        <property type="term" value="P:response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd21630">
        <property type="entry name" value="Kunitz_TAP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000028">
        <property type="entry name" value="CBN-MEC-1 protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000042">
        <property type="entry name" value="CBN-MEC-1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000024">
        <property type="entry name" value="Protein CBR-MEC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000026">
        <property type="entry name" value="Serine protease inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF217">
        <property type="entry name" value="BOOPHILIN-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="212"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="456"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="701"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="851"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="920"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="987"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1055"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1131"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1194"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1271"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1337"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1395"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="764"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="287"/>
            <end position="304"/>
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</entry>
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            <begin position="1551"/>
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            <begin position="1609"/>
            <end position="1660"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y54G2A.11b"/>
        </source>
    </evidence>
    <sequence length="74" mass="8726" checksum="077E42F6F4E4DE31" modified="2003-06-01" version="1">MRTVSKPTDQCDSRHFSKFTPRRKHIAYKTPLPCKVQSYQPSSPKPTRKPSTSTKFDDWHHKRGLHRAHLRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q86FN9</accession>
    <name>Q86FN9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y54G2A.10</name>
        <name evidence="1 3" type="ORF">Y54G2A.10</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD83498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86FN9"/>
    <dbReference type="SMR" id="Q86FN9"/>
    <dbReference type="UCSC" id="Y54G2A.10a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021875"/>
    <dbReference type="WormBase" id="Y54G2A.10b">
        <property type="protein sequence ID" value="CE33883"/>
        <property type="gene ID" value="WBGene00021875"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124618_0_0_1"/>
    <dbReference type="OrthoDB" id="5801773at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021875">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86FN9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD83498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y54G2A.10b"/>
        </source>
    </evidence>
    <sequence length="63" mass="7122" checksum="C90C28B6CCCFA01F" modified="2003-06-01" version="1">MKKVFWAADVKAANNYTMTCGQFMMDAASLVKDSDKLMAEVQKNTNLFAKANPTDFTNLQWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>Q86FP2</accession>
    <name>Q86FP2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation-transporting ATPase</fullName>
            <ecNumber evidence="12">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">catp-7</name>
        <name evidence="15" type="ORF">CELE_Y59H11AR.2</name>
        <name evidence="17" type="ORF">Y59H11AR.2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="12"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD71143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023543.1">
        <property type="nucleotide sequence ID" value="NM_001028372.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86FP2"/>
    <dbReference type="SMR" id="Q86FP2"/>
    <dbReference type="PeptideAtlas" id="Q86FP2"/>
    <dbReference type="GeneID" id="177664"/>
    <dbReference type="KEGG" id="cel:CELE_Y59H11AR.2"/>
    <dbReference type="UCSC" id="Y59H11AR.2a.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022010"/>
    <dbReference type="CTD" id="177664"/>
    <dbReference type="WormBase" id="Y59H11AR.2b">
        <property type="protein sequence ID" value="CE33894"/>
        <property type="gene ID" value="WBGene00022010"/>
        <property type="gene designation" value="catp-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_0_0_1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022010">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86FP2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000034">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000109">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF5">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="885"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="954"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1035"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1071"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="14">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD71143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="Y59H11AR.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="Q86FP2"/>
        </source>
    </evidence>
    <sequence length="1111" mass="124511" checksum="47DD17B1382E72FC" modified="2003-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N4D8-2</accession>
    <name>NLP40_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Neuropeptide-like peptides nlp-40</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="2">Peptide P1</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">P1</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="2">Peptide P2</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">P2</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="2">Peptide P3</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">P3</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="2">Peptide P4</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">P4</fullName>
            </alternativeName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="primary">nlp-40</name>
        <name evidence="5" type="ORF">Y74C9A.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2005" name="Biochem. Biophys. Res. Commun." volume="335" first="76" last="86">
            <title>Discovering neuropeptides in Caenorhabditis elegans by two dimensional liquid chromatography and mass spectrometry.</title>
            <authorList>
                <person name="Husson S.J."/>
                <person name="Clynen E."/>
                <person name="Baggerman G."/>
                <person name="De Loof A."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="16061202"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2005.07.044"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 18-29</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2006" name="J. Neurochem." volume="98" first="1999" last="2012">
            <title>Defective processing of neuropeptide precursors in Caenorhabditis elegans lacking proprotein convertase 2 (KPC-2/EGL-3): mutant analysis by mass spectrometry.</title>
            <authorList>
                <person name="Husson S.J."/>
                <person name="Clynen E."/>
                <person name="Baggerman G."/>
                <person name="Janssen T."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="16945111"/>
            <dbReference type="DOI" id="10.1111/j.1471-4159.2006.04014.x"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 52-65</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2007" name="J. Neurochem." volume="102" first="246" last="260">
            <title>Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry.</title>
            <authorList>
                <person name="Husson S.J."/>
                <person name="Janssen T."/>
                <person name="Baggerman G."/>
                <person name="Bogert B."/>
                <person name="Kahn-Kirby A.H."/>
                <person name="Ashrafi K."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="17564681"/>
            <dbReference type="DOI" id="10.1111/j.1471-4159.2007.04474.x"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 18-29 AND 68-74</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2013" name="Curr. Biol." volume="23" first="746" last="754">
            <title>Neuropeptide secreted from a pacemaker activates neurons to control a rhythmic behavior.</title>
            <authorList>
                <person name="Wang H."/>
                <person name="Girskis K."/>
                <person name="Janssen T."/>
                <person name="Chan J.P."/>
                <person name="Dasgupta K."/>
                <person name="Knowles J.A."/>
                <person name="Schoofs L."/>
                <person name="Sieburth D."/>
            </authorList>
            <dbReference type="PubMed" id="23583549"/>
            <dbReference type="DOI" id="10.1016/j.cub.2013.03.049"/>
        </citation>
        <scope>SYNTHESIS OF P1; P2; P3 AND P4</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9N4D8-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_058639"/>
        </isoform>
        <isoform>
            <id>Q9N4D8-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001293206.1">
        <property type="nucleotide sequence ID" value="NM_001306277.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y74C9A.2b">
        <property type="protein sequence ID" value="CE49228"/>
        <property type="gene ID" value="WBGene00022276"/>
        <property type="gene designation" value="nlp-40"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="16061202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="23583549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y74C9A.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y74C9A.2b"/>
        </source>
    </evidence>
    <sequence length="56" mass="6398" checksum="F764CFE37827D8A4" modified="2000-10-01" version="1" precursor="true">MVAWQPMKRSMINEDSRAPLLHAIEARLAEVLRAGERLGVNPEEVLADLRARNQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="193" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XU13</accession>
    <name>Q9XU13_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">sca-1</name>
        <name evidence="19" type="ORF">CELE_K11D9.2</name>
        <name evidence="21" type="ORF">K11D9.2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAB07263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T23606">
        <property type="entry name" value="T23606"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_499385.3">
        <property type="nucleotide sequence ID" value="NM_066984.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XU13"/>
    <dbReference type="SMR" id="Q9XU13"/>
    <dbReference type="PeptideAtlas" id="Q9XU13"/>
    <dbReference type="GeneID" id="176512"/>
    <dbReference type="UCSC" id="K11D9.2b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004736"/>
    <dbReference type="CTD" id="176512"/>
    <dbReference type="WormBase" id="K11D9.2b">
        <property type="protein sequence ID" value="CE18885"/>
        <property type="gene ID" value="WBGene00004736"/>
        <property type="gene designation" value="sca-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_2_1"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004736">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XU13">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070509">
        <property type="term" value="P:calcium ion import"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040024">
        <property type="term" value="P:dauer larval development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050891">
        <property type="term" value="P:multicellular organismal-level water homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000055">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="835"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAB07263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WormBase" id="K11D9.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XU13"/>
        </source>
    </evidence>
    <sequence length="1004" mass="109717" checksum="1A105F27EA195DD1" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBP4</accession>
    <name>U4PBP4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">unc-49</name>
        <name evidence="19" type="ORF">CELE_T21C12.1</name>
        <name evidence="21" type="ORF">T21C12.1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDH93143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380139.1">
        <property type="nucleotide sequence ID" value="NM_001392190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBP4"/>
    <dbReference type="SMR" id="U4PBP4"/>
    <dbReference type="GeneID" id="176472"/>
    <dbReference type="AGR" id="WB:WBGene00006784"/>
    <dbReference type="CTD" id="176472"/>
    <dbReference type="WormBase" id="T21C12.1k">
        <property type="protein sequence ID" value="CE49075"/>
        <property type="gene ID" value="WBGene00006784"/>
        <property type="gene designation" value="unc-49"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010920_1_6_1"/>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006784">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBP4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000067">
        <property type="entry name" value="Glycine receptor subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000154">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 16" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022249103" evidence="16">
        <location>
            <begin position="23"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="36"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="260"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDH93143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WormBase" id="T21C12.1k"/>
        </source>
    </evidence>
    <sequence length="488" mass="56294" checksum="5AA5F6B94FDD9F30" modified="2013-12-11" version="1">MARPFTLIVLLSAHLCLHVVVTQDEDSHINTQLLSSVLDRLTNRTTYDKRLRPRYGEKPVDVGITIHVSSISAVSEVDMDFTLDFYMRQTWQDPRLAFGSLDLGLSKEIDSLTVGVDYLDRLWKPDTFFPNEKKSFFHLATTHNSFLRIEGDGTVYTSQRLTVTATCPMDLKLFPMDSQHCKLEIESYGYETKDIDYYWGKKRTDLEITAVKFDTFQLPQFQPTLYFVNTTKAETSSGKYVRLALEVILVRNMGFYTMNIVIPSILIVTISWVSFWLNREASPARVGLGVTTVLTMTTLITTTNNSMPKVSYVKGLDVFLNFCFVMVFASLLEYAIVSYMNKRLVLRREKRRKAAEQQQRNEMPMFNASPKAANNNADLYFAGHNSSMNPLMEIPENCDCRTIPMMQHPRLVTDGAHTLWPAPFARPKKASKTCCQRWTPAKIDKLSRYGFPLSFSIFNIVYWLYMKYLSLNSSDKIQENDKWQQIHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBP8</accession>
    <name>U4PBP8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prion-like-(Q/N-rich)-domain-bearing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">pqn-75</name>
        <name evidence="1" type="ORF">CELE_W03D2.1</name>
        <name evidence="3" type="ORF">W03D2.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294405.1">
        <property type="nucleotide sequence ID" value="NM_001307476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBP8"/>
    <dbReference type="GeneID" id="177165"/>
    <dbReference type="KEGG" id="cel:CELE_W03D2.1"/>
    <dbReference type="AGR" id="WB:WBGene00004157"/>
    <dbReference type="CTD" id="177165"/>
    <dbReference type="WormBase" id="W03D2.1e">
        <property type="protein sequence ID" value="CE48670"/>
        <property type="gene ID" value="WBGene00004157"/>
        <property type="gene designation" value="pqn-75"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2560370_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004157">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBP8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0034">Amyloid</keyword>
    <keyword evidence="1" id="KW-0640">Prion</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="W03D2.1e"/>
        </source>
    </evidence>
    <sequence length="82" mass="9523" checksum="A59788F0E229A9B3" modified="2013-12-11" version="1">MEIIHLSETYSLKFRSFNVACKLSGNPRKETFLKHLLEVFHRPIIDNLTLSSKKCDLQWINSTFQGLKIRRKQNSVAITSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBQ2</accession>
    <name>U4PBQ2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SPRY domain-containing SOCS box protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">spsb-1</name>
        <name evidence="6" type="ORF">CELE_Y46E12BL.4</name>
        <name evidence="8" type="ORF">Y46E12BL.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001364817.1">
        <property type="nucleotide sequence ID" value="NM_001377912.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBQ2"/>
    <dbReference type="SMR" id="U4PBQ2"/>
    <dbReference type="GeneID" id="266876"/>
    <dbReference type="AGR" id="WB:WBGene00021597"/>
    <dbReference type="CTD" id="266876"/>
    <dbReference type="WormBase" id="Y46E12BL.4d">
        <property type="protein sequence ID" value="CE49083"/>
        <property type="gene ID" value="WBGene00021597"/>
        <property type="gene designation" value="spsb-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046756_2_1_1"/>
    <dbReference type="OrthoDB" id="5547302at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021597">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBQ2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03718">
        <property type="entry name" value="SOCS_SSB1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="130"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH93153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y46E12BL.4d"/>
        </source>
    </evidence>
    <sequence length="183" mass="21299" checksum="FDC8943D975CB7D3" modified="2013-12-11" version="1">MGYSRGFHVWQIEWPERQRGTHAVVGVATKNAPLHAAGYTALIGTTDESYGWDITRRECHHDSKHTMTWRYPFSNSRDVYNVPDKFYCILDMDEGYMAFATDDEFLGVAFRNLKGKTLYPIVAAVWGHCEISMRYLGSLEPEPLSLSELCRRRVRIEMGAQPEDHIEQLMIPPILKRYLMYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBQ5</accession>
    <name>U4PBQ5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">spsb-1</name>
        <name evidence="5" type="ORF">CELE_Y46E12BL.4</name>
        <name evidence="7" type="ORF">Y46E12BL.4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368257.1">
        <property type="nucleotide sequence ID" value="NM_001381675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBQ5"/>
    <dbReference type="SMR" id="U4PBQ5"/>
    <dbReference type="GeneID" id="266876"/>
    <dbReference type="AGR" id="WB:WBGene00021597"/>
    <dbReference type="CTD" id="266876"/>
    <dbReference type="WormBase" id="Y46E12BL.4g">
        <property type="protein sequence ID" value="CE48531"/>
        <property type="gene ID" value="WBGene00021597"/>
        <property type="gene designation" value="spsb-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5547302at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021597">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBQ5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd03718">
        <property type="entry name" value="SOCS_SSB1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000035">
        <property type="entry name" value="SplA/ryanodine receptor domain and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="172"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="358"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y46E12BL.4g"/>
        </source>
    </evidence>
    <sequence length="411" mass="46055" checksum="AE1F1D71DDB4A794" modified="2013-12-11" version="1">MMGPGEEEEEQLFDTTPEGSEDDDYDMVMYDESSADSSFSVPTSTVPSSVAETYETMDTDAGFSTDSEMERLVELRSVSPSSDACSTSSSTYARPAAAAHSAGNNSSSSSSNAGGGDGYHRSNSSGSSTRPVAATRERKSYAVAAGRSAPMRSLSPAHPSAVMSGMDDFLRPDRFDRIMQMTKPDQFIQEQHSWNPEDRSLNIFVKDEDKFTFHRHPVAQSTDCIRGKMGYSRGFHVWQIEWPERQRGTHAVVGVATKNAPLHAAGYTALIGTTDESYGWDITRRECHHDSKHTMTWRYPFSNSRDVYNVPDKFYCILDMDEGYMAFATDDEFLGVAFRNLKGKTLYPIVAAVWGHCEISMRYLGSLEPEPLSLSELCRRRVRIEMGAQPEDHIEQLMIPPILKRYLMYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBR0</accession>
    <name>U4PBR0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">cdh-8</name>
        <name evidence="12" type="ORF">CELE_F18F11.3</name>
        <name evidence="14" type="ORF">F18F11.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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        <property type="entry name" value="CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652689" evidence="10">
        <location>
            <begin position="23"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1583"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="54"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="126"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="454"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="549"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="779"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="855"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="958"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1178"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1270"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1396"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1645"/>
            <end position="1669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDH93168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F18F11.3h"/>
        </source>
    </evidence>
    <sequence length="1669" mass="184148" checksum="FA9AED0D69769ABE" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBR7</accession>
    <name>U4PBR7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">dsl-3</name>
        <name evidence="10" type="ORF">CELE_Y41D4B.10</name>
        <name evidence="12" type="ORF">Y41D4B.10</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368285.1">
        <property type="nucleotide sequence ID" value="NM_001380053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBR7"/>
    <dbReference type="GeneID" id="176970"/>
    <dbReference type="KEGG" id="cel:CELE_Y41D4B.10"/>
    <dbReference type="AGR" id="WB:WBGene00001105"/>
    <dbReference type="CTD" id="176970"/>
    <dbReference type="WormBase" id="Y41D4B.10b">
        <property type="protein sequence ID" value="CE48623"/>
        <property type="gene ID" value="WBGene00001105"/>
        <property type="gene designation" value="dsl-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077229_0_0_1"/>
    <dbReference type="OrthoDB" id="5782642at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001105">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBR7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039178">
        <property type="entry name" value="Lag2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22669:SF10">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22669">
        <property type="entry name" value="DELTA/SERRATE/LAG-2 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1 7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="83"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="103"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="145"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDH93310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y41D4B.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBR7"/>
        </source>
    </evidence>
    <sequence length="212" mass="23881" checksum="02EC09E8F82E7E56" modified="2013-12-11" version="1">MISSNETVKMHKVPMKMDGSEYQITIFVINQDRLDIDNATITTSFVPKNGQISPLTVMFPFTGIRMRVGCDEQWHGEKCDVFCCSETASRVGKVCNSHGQLGCPQGKRGLDCALPISKKWCKCQNNGACISSFGKNLHEKMQCECQLGFRGSHCEERVDNIEMKSTYGVDPKKFEIATAKMLYESVVDNELVEVKRERTGGHFLQNLRINDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBR8</accession>
    <name>U4PBR8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">par-3</name>
        <name evidence="3" type="ORF">CELE_F54E7.3</name>
        <name evidence="5" type="ORF">F54E7.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDH93173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368258.1">
        <property type="nucleotide sequence ID" value="NM_001379721.1"/>
    </dbReference>
    <dbReference type="SMR" id="U4PBR8"/>
    <dbReference type="GeneID" id="175783"/>
    <dbReference type="AGR" id="WB:WBGene00003918"/>
    <dbReference type="CTD" id="175783"/>
    <dbReference type="WormBase" id="F54E7.3g">
        <property type="protein sequence ID" value="CE48549"/>
        <property type="gene ID" value="WBGene00003918"/>
        <property type="gene designation" value="par-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264899at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003918">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBR8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd23059">
        <property type="entry name" value="PDZ3_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000272">
        <property type="entry name" value="Partitioning defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000290">
        <property type="entry name" value="Partitioning defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000291">
        <property type="entry name" value="Partitioning defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF17">
        <property type="entry name" value="BAZOOKA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="302"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="436"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="580"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F54E7.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBR8"/>
        </source>
    </evidence>
    <sequence length="1300" mass="140929" checksum="557EFEA588F84B74" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBS1</accession>
    <name>U4PBS1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nhr-274</name>
        <name evidence="13" type="ORF">CELE_Y41D4B.21</name>
        <name evidence="15" type="ORF">Y41D4B.21</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368290.1">
        <property type="nucleotide sequence ID" value="NM_001380054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBS1"/>
    <dbReference type="SMR" id="U4PBS1"/>
    <dbReference type="GeneID" id="189825"/>
    <dbReference type="AGR" id="WB:WBGene00021522"/>
    <dbReference type="CTD" id="189825"/>
    <dbReference type="WormBase" id="Y41D4B.21c">
        <property type="protein sequence ID" value="CE48581"/>
        <property type="gene ID" value="WBGene00021522"/>
        <property type="gene designation" value="nhr-274"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5772425at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021522">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBS1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587:SF3">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
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        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="139"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDH93315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="Y41D4B.21c"/>
        </source>
    </evidence>
    <sequence length="417" mass="47126" checksum="E75495725B9F6B6C" modified="2013-12-11" version="1">MSSGEVMTYGEIHRISTSSPDTSPPGTSTQDDTDGCAVCGDRVNGKRYGAPACLGCIVFFRRAVTNEVTYKCLKGGTCVITNESRCICRYCRLQKCYTVGMKASAIQRRDVMGPRKPKIKESIVKTEIIEEVPKLIMSSNPSSTGSMSEGPPKHKRPLLEDLVEVQRWQCSKHHSFFEAHEAINLDGDLSSMTYLKLNGTLHRRARARDVNSMLKLGLIDAATWGNQFDLFRRLSTEEKKHILTEFGFTFMLVDQGYKTAQKAEKGFWLLQNDTYMHEDYFLGLPEEDARKENAATKAKLHPLFVNESLNCVGYPFKNLQIDEHECAVLKTILLLTQQGVFKHCVNEVKHLYDCCMTELMGHSQRKYPDTAAERFGTIILLTSSIRCAINALYNQTRVSDVFDLMKFDPLVRDVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBS3</accession>
    <name>U4PBS3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">par-3</name>
        <name evidence="3" type="ORF">CELE_F54E7.3</name>
        <name evidence="5" type="ORF">F54E7.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDH93178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360237.1">
        <property type="nucleotide sequence ID" value="NM_001372595.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBS3"/>
    <dbReference type="SMR" id="U4PBS3"/>
    <dbReference type="GeneID" id="175783"/>
    <dbReference type="AGR" id="WB:WBGene00003918"/>
    <dbReference type="CTD" id="175783"/>
    <dbReference type="WormBase" id="F54E7.3l">
        <property type="protein sequence ID" value="CE49082"/>
        <property type="gene ID" value="WBGene00003918"/>
        <property type="gene designation" value="par-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264899at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003918">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBS3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd23059">
        <property type="entry name" value="PDZ3_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000272">
        <property type="entry name" value="Partitioning defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000290">
        <property type="entry name" value="Partitioning defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000291">
        <property type="entry name" value="Partitioning defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF17">
        <property type="entry name" value="BAZOOKA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="302"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="436"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="580"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F54E7.3l"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBS3"/>
        </source>
    </evidence>
    <sequence length="1248" mass="135361" checksum="2175EB17FA0D079E" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBS6</accession>
    <name>U4PBS6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T20D4.11-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F10G2.10</name>
        <name evidence="2 4" type="ORF">F10G2.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CDH93320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294770.1">
        <property type="nucleotide sequence ID" value="NM_001307841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBS6"/>
    <dbReference type="GeneID" id="24104419"/>
    <dbReference type="AGR" id="WB:WBGene00235324"/>
    <dbReference type="CTD" id="24104419"/>
    <dbReference type="WormBase" id="F10G2.10b">
        <property type="protein sequence ID" value="CE48760"/>
        <property type="gene ID" value="WBGene00235324"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078890_1_0_1"/>
    <dbReference type="OrthoDB" id="5790976at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBS6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002542">
        <property type="entry name" value="T20D4.11-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21453:SF10">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21453">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01579">
        <property type="entry name" value="DUF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T20D4.11-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F10G2.10b"/>
        </source>
    </evidence>
    <sequence length="140" mass="16337" checksum="D55B262C75E52274" modified="2013-12-11" version="1">MSHFNSTAERIIKCFDNLPCRTTLDVKIRNRVGAYRDTMFALTDSFVKCAKVLEAHNSDCFYSWDPFLGIDGDGRILENFDTRDVCKNYFGPRDCIRHEIIDYCTVEAWRSFKKSAKAFGEQIYGCDFRGVFVFPVRYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBS8</accession>
    <name>U4PBS8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">pde-3</name>
        <name evidence="10" type="ORF">CELE_E01F3.1</name>
        <name evidence="12" type="ORF">E01F3.1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368261.1">
        <property type="nucleotide sequence ID" value="NM_001381670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBS8"/>
    <dbReference type="SMR" id="U4PBS8"/>
    <dbReference type="GeneID" id="183981"/>
    <dbReference type="AGR" id="WB:WBGene00008443"/>
    <dbReference type="CTD" id="183981"/>
    <dbReference type="WormBase" id="E01F3.1f">
        <property type="protein sequence ID" value="CE37890"/>
        <property type="gene ID" value="WBGene00008443"/>
        <property type="gene designation" value="pde-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008443">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBS8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000018">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="181"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDH93183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="E01F3.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBS8"/>
        </source>
    </evidence>
    <sequence length="578" mass="65145" checksum="A14AEABA9965FE9F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC11</accession>
    <name>U4PC11_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y69A2AR.1</name>
        <name evidence="1 3" type="ORF">Y69A2AR.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294603.1">
        <property type="nucleotide sequence ID" value="NM_001307674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC11"/>
    <dbReference type="PeptideAtlas" id="U4PC11"/>
    <dbReference type="GeneID" id="177051"/>
    <dbReference type="KEGG" id="cel:CELE_Y69A2AR.1"/>
    <dbReference type="AGR" id="WB:WBGene00022074"/>
    <dbReference type="CTD" id="177051"/>
    <dbReference type="WormBase" id="Y69A2AR.1g">
        <property type="protein sequence ID" value="CE49012"/>
        <property type="gene ID" value="WBGene00022074"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044520_0_0_1"/>
    <dbReference type="OrthoDB" id="5780950at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022074">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC11">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y69A2AR.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="U4PC11"/>
        </source>
    </evidence>
    <sequence length="313" mass="35776" checksum="808610A8239497C0" modified="2013-12-11" version="1">MFIKKWTCKQLDYNICTEFNQPQHLRRLVHMFKPTDITVSLHFGPYIPSATAHEPNSMHNHLAALSDTTLAMEKDFRLDCAHALSLPPDSSKKELGMLYGEAGKGRAFGIQMLRTLTAIRKFVGMMAEKRMAQTKGVAIRKFVVNGPGIHDKPCAKLQQLLKEDGLDEANKMRGAYATGERVYVCVRNDLRRAFKYSLAMPATAFKMSIGNEQLLLFTKSVPVFHCFFRTNVDEQGVVQLITEWQKGERNIEEIQLHLDRVIEPNFVDHLNADHADPKRVKVRRVVNGRKTTLYIERDRLGSRHLALRTLDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC14</accession>
    <name>U4PC14_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHD finger protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y77E11A.7</name>
        <name evidence="2 4" type="ORF">Y77E11A.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294494.1">
        <property type="nucleotide sequence ID" value="NM_001307565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC14"/>
    <dbReference type="GeneID" id="176951"/>
    <dbReference type="AGR" id="WB:WBGene00022310"/>
    <dbReference type="CTD" id="176951"/>
    <dbReference type="WormBase" id="Y77E11A.7g">
        <property type="protein sequence ID" value="CE48851"/>
        <property type="gene ID" value="WBGene00022310"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863611at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022310">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC14">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y77E11A.7g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PC14"/>
        </source>
    </evidence>
    <sequence length="607" mass="69482" checksum="03759DC013AAE598" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC16</accession>
    <name>U4PC16_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CELE_Y69A2AR.16</name>
        <name evidence="9 11" type="ORF">Y69A2AR.16</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC16"/>
    <dbReference type="SMR" id="U4PC16"/>
    <dbReference type="PeptideAtlas" id="U4PC16"/>
    <dbReference type="AGR" id="WB:WBGene00022087"/>
    <dbReference type="WormBase" id="Y69A2AR.16c">
        <property type="protein sequence ID" value="CE48929"/>
        <property type="gene ID" value="WBGene00022087"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009881_0_0_1"/>
    <dbReference type="OrthoDB" id="5548448at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022087">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC16">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000993">
        <property type="entry name" value="Protein CBG22497"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDH93412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y69A2AR.16c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="U4PC16"/>
        </source>
    </evidence>
    <sequence length="617" mass="69616" checksum="33B846B6608FFC81" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC21</accession>
    <name>U4PC21_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HORMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">mdf-2</name>
        <name evidence="8" type="ORF">CELE_Y69A2AR.30</name>
        <name evidence="10" type="ORF">Y69A2AR.30</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294613.1">
        <property type="nucleotide sequence ID" value="NM_001307684.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC21"/>
    <dbReference type="SMR" id="U4PC21"/>
    <dbReference type="PeptideAtlas" id="U4PC21"/>
    <dbReference type="GeneID" id="177046"/>
    <dbReference type="AGR" id="WB:WBGene00003161"/>
    <dbReference type="CTD" id="177046"/>
    <dbReference type="WormBase" id="Y69A2AR.30c">
        <property type="protein sequence ID" value="CE48529"/>
        <property type="gene ID" value="WBGene00003161"/>
        <property type="gene designation" value="mdf-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072097_0_1_1"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003161">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC21">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDH93417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y69A2AR.30c"/>
        </source>
    </evidence>
    <sequence length="140" mass="16224" checksum="6E44BE52AC27FBF6" modified="2013-12-11" version="1">MDPLLQQVEYWLAKRQLKRLVMVISEVKTKEVVERWQFDIHTENLAEEGENAHRVKEEKKIRQEISDVIRQITASVSFLPLLEEPVSFDVLIYTGKDTQAPEDWTESGACLIQNSETVQLRSFSTSVHSVNTNVQYKADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC30</accession>
    <name>U4PC30_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SRR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">B0546.3</name>
        <name evidence="2" type="ORF">CELE_B0546.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368282.1">
        <property type="nucleotide sequence ID" value="NM_001380142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC30"/>
    <dbReference type="SMR" id="U4PC30"/>
    <dbReference type="GeneID" id="182030"/>
    <dbReference type="AGR" id="WB:WBGene00015250"/>
    <dbReference type="CTD" id="182030"/>
    <dbReference type="WormBase" id="B0546.3b">
        <property type="protein sequence ID" value="CE48872"/>
        <property type="gene ID" value="WBGene00015250"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052879_0_0_1"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015250">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC30">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="B0546.3b"/>
        </source>
    </evidence>
    <sequence length="324" mass="38134" checksum="CD29092A88F2C99E" modified="2013-12-11" version="1">MNITEREAFSKISQMNGNLQPDALRREMEDAEDRNHHVMRRRMFEAMRMANFEDRVHPRFRRQGEPNYFNRFADGAMPAVRFSDFERLRERTLMAEDTAAIIWETLQRFNLAIVASIQGNNESLLEMGFTRELGHQYPGIRLLMEGHPYDANPGTDRMLAEMFNRMTRELEHGALFEAEMFDEDDEPDEEHNEDPDHEFFPLQDLAIRQIMANHMGAPVPVLQMAPGVGVRFPQLPAQFQPQFGGRVQAHLFPQPGFVQFENLEHIIGEEHHAEYQQLREDYRQAHVDLIGPELEQRRQEILDRMREIYNMRRPYPNDPVRFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC39</accession>
    <name>U4PC39_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1014-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y41D4B.11</name>
        <name evidence="1 3" type="ORF">Y41D4B.11</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC39"/>
    <dbReference type="PeptideAtlas" id="U4PC39"/>
    <dbReference type="AGR" id="WB:WBGene00021514"/>
    <dbReference type="WormBase" id="Y41D4B.11b">
        <property type="protein sequence ID" value="CE49014"/>
        <property type="gene ID" value="WBGene00021514"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067185_0_0_1"/>
    <dbReference type="OrthoDB" id="5876637at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021514">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC39">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026680">
        <property type="entry name" value="CCDC137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21838">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21838:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y41D4B.11b"/>
        </source>
    </evidence>
    <sequence length="66" mass="7216" checksum="B224B8EB4110C5F5" modified="2013-12-11" version="1">MAKAGQKTTLLLHSMLQKGGGQKTEYLNNSTKIQEERQKVIDAYRDMKKQKRIAAAFAAAASSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC40</accession>
    <name>U4PC40_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WAPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">wapl-1</name>
        <name evidence="4" type="ORF">CELE_R08C7.10</name>
        <name evidence="6" type="ORF">R08C7.10</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368333.1">
        <property type="nucleotide sequence ID" value="NM_001380190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC40"/>
    <dbReference type="SMR" id="U4PC40"/>
    <dbReference type="GeneID" id="177211"/>
    <dbReference type="AGR" id="WB:WBGene00019953"/>
    <dbReference type="CTD" id="177211"/>
    <dbReference type="WormBase" id="R08C7.10d">
        <property type="protein sequence ID" value="CE48984"/>
        <property type="gene ID" value="WBGene00019953"/>
        <property type="gene designation" value="wapl-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019953">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC40">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="3">
        <location>
            <begin position="205"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDH93433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="R08C7.10d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="U4PC40"/>
        </source>
    </evidence>
    <sequence length="615" mass="69155" checksum="43A5B49D47EAE61D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC44</accession>
    <name>U4PC44_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nhr-274</name>
        <name evidence="5" type="ORF">CELE_Y41D4B.21</name>
        <name evidence="7" type="ORF">Y41D4B.21</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294522.1">
        <property type="nucleotide sequence ID" value="NM_001307593.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC44"/>
    <dbReference type="SMR" id="U4PC44"/>
    <dbReference type="GeneID" id="189825"/>
    <dbReference type="KEGG" id="cel:CELE_Y41D4B.21"/>
    <dbReference type="AGR" id="WB:WBGene00021522"/>
    <dbReference type="CTD" id="189825"/>
    <dbReference type="WormBase" id="Y41D4B.21d">
        <property type="protein sequence ID" value="CE48729"/>
        <property type="gene ID" value="WBGene00021522"/>
        <property type="gene designation" value="nhr-274"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007368_0_0_1"/>
    <dbReference type="OrthoDB" id="5772425at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021522">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC44">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587:SF3">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="39"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y41D4B.21d"/>
        </source>
    </evidence>
    <sequence length="317" mass="36395" checksum="EC029632FD084B19" modified="2013-12-11" version="1">MKASAIQRRDVMGPRKPKIKESIVKTEIIEEVPKLIMSSNPSSTGSMSEGPPKHKRPLLEDLVEVQRWQCSKHHSFFEAHEAINLDGDLYAHMHLKLNGTLHRRARARDVNSMLKLGLIDAATWGNQFDLFRRLSTEEKKHILTEFGFTFMLVDQGYKTAQKAEKGFWLLQNDTYMHEDYFLGLPEEDARKENAATKAKLHPLFVNESLNCVGYPFKNLQIDEHECAVLKTILLLTQQGVFKHCVNEVKHLYDCCMTELMGHSQRKYPDTAAERFGTIILLTSSIRCAINALYNQTRVSDVFDLMKFDPLVRDVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC51</accession>
    <name>U4PC51_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Alpha-ketoglutarate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">ogdh-1</name>
        <name evidence="15" type="ORF">CELE_T22B11.5</name>
        <name evidence="17" type="ORF">T22B11.5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368291.1">
        <property type="nucleotide sequence ID" value="NM_001380203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC51"/>
    <dbReference type="SMR" id="U4PC51"/>
    <dbReference type="PeptideAtlas" id="U4PC51"/>
    <dbReference type="GeneID" id="177235"/>
    <dbReference type="AGR" id="WB:WBGene00020679"/>
    <dbReference type="CTD" id="177235"/>
    <dbReference type="WormBase" id="T22B11.5b">
        <property type="protein sequence ID" value="CE48823"/>
        <property type="gene ID" value="WBGene00020679"/>
        <property type="gene designation" value="ogdh-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004709_1_1_1"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020679">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC51">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000007">
        <property type="entry name" value="2-oxoglutarate dehydrogenase e1 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000063">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="14">
        <location>
            <begin position="424"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDH93321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="T22B11.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="U4PC51"/>
        </source>
    </evidence>
    <sequence length="802" mass="90994" checksum="F4128342DEEE1D8A" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKQ3</accession>
    <name>V6CKQ3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Growth-regulating factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mex-3</name>
        <name evidence="2" type="ORF">CELE_F53G12.5</name>
        <name evidence="4" type="ORF">F53G12.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293263.1">
        <property type="nucleotide sequence ID" value="NM_001306334.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKQ3"/>
    <dbReference type="PeptideAtlas" id="V6CKQ3"/>
    <dbReference type="GeneID" id="171607"/>
    <dbReference type="KEGG" id="cel:CELE_F53G12.5"/>
    <dbReference type="AGR" id="WB:WBGene00003229"/>
    <dbReference type="CTD" id="171607"/>
    <dbReference type="WormBase" id="F53G12.5c">
        <property type="protein sequence ID" value="CE49254"/>
        <property type="gene ID" value="WBGene00003229"/>
        <property type="gene designation" value="mex-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618539_0_0_1"/>
    <dbReference type="OrthoDB" id="427410at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003229">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKQ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F53G12.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="V6CKQ3"/>
        </source>
    </evidence>
    <sequence length="180" mass="19221" checksum="B1EBB510813BD274" modified="2014-02-19" version="1">MQEAQQQSMFYRRAFGNSNPFNQKEMSSSPFGMESSLGLDALLRSFPSMRSSLTPESLSGTGLSSRPSLGGGQSAKQDLPTYDYWGTNNSLNDIMENEILSRKYDALSAWSSMGLEKREESPTNGLMSSLKGTSAGFGLLSTIWSGGNMNLSPGSLASASASPTSSTCDHNDHTLVPING</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL61</accession>
    <name>V6CL61_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-binding protein G(s) subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Adenylate cyclase-stimulating G alpha protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">gsa-1</name>
        <name evidence="11" type="ORF">CELE_R06A10.2</name>
        <name evidence="13" type="ORF">R06A10.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the G-alpha family. G(s) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368357.1">
        <property type="nucleotide sequence ID" value="NM_001380932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CL61"/>
    <dbReference type="SMR" id="V6CL61"/>
    <dbReference type="PeptideAtlas" id="V6CL61"/>
    <dbReference type="GeneID" id="171687"/>
    <dbReference type="AGR" id="WB:WBGene00001745"/>
    <dbReference type="CTD" id="171687"/>
    <dbReference type="WormBase" id="R06A10.2b">
        <property type="protein sequence ID" value="CE49189"/>
        <property type="gene ID" value="WBGene00001745"/>
        <property type="gene designation" value="gsa-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_3_0_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CL61">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000003">
        <property type="entry name" value="Guanine nucleotide-binding protein G(S) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006178">
        <property type="entry name" value="Guanine nucleotide-binding protein G(s) subunit alpha isoforms short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000367">
        <property type="entry name" value="Gprotein_alpha_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF212">
        <property type="entry name" value="G PROTEIN ALPHA S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00443">
        <property type="entry name" value="GPROTEINAS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="89"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDK13319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="R06A10.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="V6CL61"/>
        </source>
    </evidence>
    <sequence length="285" mass="33961" checksum="E9EC1870A4EC9BB5" modified="2014-02-19" version="1">MDEIVPKVSLDDPSTAISRDYILRITNDPEDNYPSEFYDHILTCWKDKGVMACYERSSEYQLIDCAQYFLDKVDVVRQNNYDPSEQDILRCRVMTTGIFETKFEVDKVRFHMFDVGGQRDERRKWIQCFNDVTAIIFVCASSSYNLVLWEDNTQNRLRESLALFKNIWNNRWLKTISVILFLNKQDLLSEKIKAKRYLLESFFPEFEGYNLPNDAVFDNQEDKDVVRAKYFIRGEFLRISTANSDGRHHCYPHFTCAVDTENIRRVFNDCRDIIQRIHLRQYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL68</accession>
    <name>V6CL68_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">csk-1</name>
        <name evidence="2" type="ORF">CELE_Y48G1C.2</name>
        <name evidence="4" type="ORF">Y48G1C.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293163.1">
        <property type="nucleotide sequence ID" value="NM_001306234.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CL68"/>
    <dbReference type="SMR" id="V6CL68"/>
    <dbReference type="GeneID" id="266817"/>
    <dbReference type="AGR" id="WB:WBGene00000812"/>
    <dbReference type="CTD" id="266817"/>
    <dbReference type="WormBase" id="Y48G1C.2c">
        <property type="protein sequence ID" value="CE49449"/>
        <property type="gene ID" value="WBGene00000812"/>
        <property type="gene designation" value="csk-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_7_2_1"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000812">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CL68">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y48G1C.2c"/>
        </source>
    </evidence>
    <sequence length="43" mass="4863" checksum="AD575D3E208FBBFA" modified="2014-02-19" version="1">MEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLTTIRNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL74</accession>
    <name>V6CL74_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">hecd-1</name>
        <name evidence="15" type="ORF">C34D4.14</name>
        <name evidence="13" type="ORF">CELE_C34D4.14</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293689.1">
        <property type="nucleotide sequence ID" value="NM_001306760.2"/>
    </dbReference>
    <dbReference type="SMR" id="V6CL74"/>
    <dbReference type="PeptideAtlas" id="V6CL74"/>
    <dbReference type="GeneID" id="177486"/>
    <dbReference type="AGR" id="WB:WBGene00016405"/>
    <dbReference type="CTD" id="177486"/>
    <dbReference type="WormBase" id="C34D4.14b">
        <property type="protein sequence ID" value="CE49373"/>
        <property type="gene ID" value="WBGene00016405"/>
        <property type="gene designation" value="hecd-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412600at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016405">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CL74">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000320">
        <property type="entry name" value="E3 ubiquitin-protein ligase hecd-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000033">
        <property type="entry name" value="E3 ubiquitin-protein ligase hecd-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000051">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000007">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
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        <source>
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        <source>
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    <sequence length="2611" mass="288151" checksum="84E35FFAB66DEB4B" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>V6CL75</accession>
    <name>V6CL75_CAEEL</name>
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        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
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        <name evidence="13 15" type="primary">hecd-1</name>
        <name evidence="15" type="ORF">C34D4.14</name>
        <name evidence="13" type="ORF">CELE_C34D4.14</name>
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    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
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            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        <text evidence="2 9">Protein modification; protein ubiquitination.</text>
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    <comment type="similarity">
        <text evidence="3 9">Belongs to the UPL family. K-HECT subfamily.</text>
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    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1632"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1701"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1721"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1777"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="2582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDK13345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="C34D4.14g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="V6CL75"/>
        </source>
    </evidence>
    <sequence length="2613" mass="288392" checksum="C870F0B647444453" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BQP2-2</accession>
    <name>GCY25_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Receptor-type guanylate cyclase gcy-25</fullName>
            <ecNumber evidence="1">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gcy-25</name>
        <name evidence="4" type="ORF">Y105C5B.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2006" name="Genetics" volume="173" first="131" last="149">
            <title>Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases.</title>
            <authorList>
                <person name="Ortiz C.O."/>
                <person name="Etchberger J.F."/>
                <person name="Posy S.L."/>
                <person name="Frokjaer-Jensen C."/>
                <person name="Lockery S."/>
                <person name="Honig B."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="16547101"/>
            <dbReference type="DOI" id="10.1534/genetics.106.055749"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A078BQP2-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_057708"/>
        </isoform>
        <isoform>
            <id>A0A078BQP2-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001294117.1">
        <property type="nucleotide sequence ID" value="NM_001307188.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y105C5B.2b">
        <property type="protein sequence ID" value="CE50104"/>
        <property type="gene ID" value="WBGene00001549"/>
        <property type="gene designation" value="gcy-25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q19187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y105C5B.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y105C5B.2b"/>
        </source>
    </evidence>
    <sequence length="981" mass="111065" checksum="1A7C441D9214D7E9" modified="2014-10-29" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MAT8</accession>
    <name>A0A131MAT8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Period protein homolog lin-42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">lin-42</name>
        <name evidence="2" type="ORF">CELE_F47F6.1</name>
        <name evidence="4" type="ORF">F47F6.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309560.1">
        <property type="nucleotide sequence ID" value="NM_001322705.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MAT8"/>
    <dbReference type="SMR" id="A0A131MAT8"/>
    <dbReference type="GeneID" id="173503"/>
    <dbReference type="AGR" id="WB:WBGene00018572"/>
    <dbReference type="CTD" id="173503"/>
    <dbReference type="WormBase" id="F47F6.1e">
        <property type="protein sequence ID" value="CE51451"/>
        <property type="gene ID" value="WBGene00018572"/>
        <property type="gene designation" value="lin-42"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7788983at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018572">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MAT8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F47F6.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MAT8"/>
        </source>
    </evidence>
    <sequence length="336" mass="36653" checksum="03487A31368F493A" modified="2016-05-11" version="1">MELVVARHRICSLPIGDSDVISSPPPGIQSNTLPPVMAKTFEDELRTIMNKPVPSTSRHSHHHHHSSLKDQNQGFPANIDLGAYIDKIVEQLVVNSTAQQQQKVAVAAAAAAQAAQAAVVATAQIRKVASAPPTTSTDPPLSYTQINCLENVHRLLKSQSRPESPAKQDEPFDEKKYPPQTPLTREALTLHTKRFEDEYKDTWCRRLKRLSDDVPSSPPAKRTTPIHWTSSSQNHYRTMAPAPPPPPGKNYQITYTPLDDLTDQKSTNTKSDVENVAYPISGSKFSTPMRLSIDGLLPRGATSTGGASPTSGTNSPPVFPKTSSSSSLLMLRDSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB05</accession>
    <name>A0A131MB05_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">cutl-12</name>
        <name evidence="11" type="ORF">CELE_T22C8.7</name>
        <name evidence="13" type="ORF">T22C8.7</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CZR14495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309579.1">
        <property type="nucleotide sequence ID" value="NM_001322750.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB05"/>
    <dbReference type="SMR" id="A0A131MB05"/>
    <dbReference type="GeneID" id="188735"/>
    <dbReference type="AGR" id="WB:WBGene00011928"/>
    <dbReference type="CTD" id="188735"/>
    <dbReference type="WormBase" id="T22C8.7b">
        <property type="protein sequence ID" value="CE51479"/>
        <property type="gene ID" value="WBGene00011928"/>
        <property type="gene designation" value="cutl-12"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011928">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MB05">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF58">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CZR14495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="T22C8.7b"/>
        </source>
    </evidence>
    <sequence length="487" mass="54747" checksum="6A1D8FE916E05790" modified="2016-05-11" version="1">MDLPFRGPCNVRRRRNVAPPSISYDVTVIIQHHPLFVTSFDKAYRLNCIYRQQESTLQQRINVSDIPSTALQSKNAPKCRYDVLSGSLNGPVVRFANVGDVVVHKWTCDSDRFGFVVHSCVVRDESGKDFQFIDERGCVTDFSLFPEVSYSDDLKSAFTAVRAFRYADQVMVHFSCQITTCQKQENGCEGISPPICRPMDLGPIKVHYVKHEKNGEKFDEGGGVETLPPRTENTSEGSTTTVRSTTTRERAQAFSTTTHKTTTSSSLQLKTVQRDEDNNSFSPSSKFRNGYNFPNVESGEGVGQDNTAEFGVKRKSSDAGVNEYGIEIAKDESQAKQNKISLVAEPEKLPKREVFHVETISKTMDSELEPLPYPTKASVYQHRSPRSHKRVLEDANITLEVETTKIMILENEPSAEKFRLGEAREQSGPEPMKCTTSENYVSNTLLLTTLGVLQVISILALITQRFYYKKSIDNLIYADDRPGSRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB07</accession>
    <name>A0A131MB07_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">nhr-149</name>
        <name evidence="13" type="ORF">C03G6.12</name>
        <name evidence="11" type="ORF">CELE_C03G6.12</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309617.1">
        <property type="nucleotide sequence ID" value="NM_001322569.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB07"/>
    <dbReference type="SMR" id="A0A131MB07"/>
    <dbReference type="GeneID" id="182174"/>
    <dbReference type="KEGG" id="cel:CELE_C03G6.12"/>
    <dbReference type="AGR" id="WB:WBGene00015397"/>
    <dbReference type="CTD" id="182174"/>
    <dbReference type="WormBase" id="C03G6.12b">
        <property type="protein sequence ID" value="CE51482"/>
        <property type="gene ID" value="WBGene00015397"/>
        <property type="gene designation" value="nhr-149"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984314at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015397">
        <property type="expression patterns" value="Expressed in embryo"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MB07">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000053">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NR LBD" evidence="10">
        <location>
            <begin position="78"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CZR14539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C03G6.12b"/>
        </source>
    </evidence>
    <sequence length="318" mass="36727" checksum="57470F586BE29A89" modified="2016-05-11" version="1">MSLSKCRACRFQRCLNVGMNPAAIQCDGNPKKDSSHFRDFDSIDEKIKNIIDTLTYVELKLENYRKSAYNPVLSLSTGLDDLIEGSCSLSLAEIYGPMSGWPLGFEEHQLPSSSMRNVSCEEPCPVSNRKYWTHCNMLTTIEYFKTFKFFHELSSRDKFVLARHTLLLCQNLHISHYTVSHNFDSCLQPDGSMQPKQDERHYPIAMMSIEPLVRCKIQHVEYVLLKAICFCNPAVPELSQNAQRILAKERYCFADILINHCLRNYTDGPGHFAELIGIFNLLETQQRMFKDLHIMYVVPLMNKFSRELIKFLSDVMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB12</accession>
    <name>A0A131MB12_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="16">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">daf-4</name>
        <name evidence="22" type="ORF">C05D2.1</name>
        <name evidence="20" type="ORF">CELE_C05D2.1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18673"/>
            <dbReference type="Rhea" id="RHEA-COMP:11022"/>
            <dbReference type="Rhea" id="RHEA-COMP:11023"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="16"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CZR14508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309588.1">
        <property type="nucleotide sequence ID" value="NM_001322590.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB12"/>
    <dbReference type="SMR" id="A0A131MB12"/>
    <dbReference type="GeneID" id="175781"/>
    <dbReference type="AGR" id="WB:WBGene00000900"/>
    <dbReference type="CTD" id="175781"/>
    <dbReference type="WormBase" id="C05D2.1e">
        <property type="protein sequence ID" value="CE51327"/>
        <property type="gene ID" value="WBGene00000900"/>
        <property type="gene designation" value="daf-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="547665at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000900">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MB12">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23617">
        <property type="entry name" value="TFP_LU_ECD_Daf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000487">
        <property type="entry name" value="Anti-Muellerian hormone type-2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000958">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF100">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12 16 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007283651" description="Serine/threonine-protein kinase receptor" evidence="18">
        <location>
            <begin position="32"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="285"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="584"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CZR14508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="C05D2.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MB12"/>
        </source>
    </evidence>
    <sequence length="723" mass="82161" checksum="A8C764E907EE031D" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB16</accession>
    <name>A0A131MB16_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Annexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nex-4</name>
        <name evidence="7" type="ORF">C37H5.1</name>
        <name evidence="5" type="ORF">CELE_C37H5.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309625.1">
        <property type="nucleotide sequence ID" value="NM_001322553.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB16"/>
    <dbReference type="SMR" id="A0A131MB16"/>
    <dbReference type="PaxDb" id="6239-C37H5.1"/>
    <dbReference type="GeneID" id="183294"/>
    <dbReference type="KEGG" id="cel:CELE_C37H5.1"/>
    <dbReference type="AGR" id="WB:WBGene00003591"/>
    <dbReference type="CTD" id="183294"/>
    <dbReference type="WormBase" id="C37H5.1b">
        <property type="protein sequence ID" value="CE51303"/>
        <property type="gene ID" value="WBGene00003591"/>
        <property type="gene designation" value="nex-4"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003591">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MB16">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000023">
        <property type="entry name" value="AnNEXin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000024">
        <property type="entry name" value="AnNEXin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF243">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CZR14549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C37H5.1b"/>
        </source>
    </evidence>
    <sequence length="390" mass="44952" checksum="D0175F42E4C76DCC" modified="2016-05-11" version="1">MFSDRGVSIEVTRADPRERTLSTGSSLDSDTSHRSKNIPMIFQMYESQYEDLRGTIYGPSSPDFHPVQASETLRSSLHGLETKDQTIINTVLYHNNFQRQKILGAYEDMYSRKLLEDLEEECGGFFFEMCQALFKPAPNYDAQCVYKSLSNRHGDRSVAIEIACTRSPRQMRALRDTYQIDYRKSLDKDLTVKVEGVVGKMMHLLLCNNREEGLGVRVNDELVDKHVKILMTTTIDDIAKNVNLFEELFIGHSWKHIGTVLDKVDEARKDVQDIESIIRRNKNIHSEIRLILLTIARVSRNIQIYFAEKLRTAMTAERVDQSTIIRICVSRSEIDLQDISLEYKRKYQRPLEHDICQSTSGEYTRMICTLLSGFNNLENSFAPTPESIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB51</accession>
    <name>A0A131MB51_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activated in Blocked Unfolded protein response</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pqn-16</name>
        <name evidence="4" type="ORF">C24B5.5</name>
        <name evidence="2" type="ORF">CELE_C24B5.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309624.1">
        <property type="nucleotide sequence ID" value="NM_001322581.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB51"/>
    <dbReference type="GeneID" id="182836"/>
    <dbReference type="KEGG" id="cel:CELE_C24B5.5"/>
    <dbReference type="AGR" id="WB:WBGene00004107"/>
    <dbReference type="CTD" id="182836"/>
    <dbReference type="WormBase" id="C24B5.5b">
        <property type="protein sequence ID" value="CE51445"/>
        <property type="gene ID" value="WBGene00004107"/>
        <property type="gene designation" value="pqn-16"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876760at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MB51">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31895:SF11">
        <property type="entry name" value="PRION-LIKE-(Q_N-RICH)-DOMAIN-BEARING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31895">
        <property type="entry name" value="PROTEIN CBG03177-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007283649" evidence="1">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CZR14548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C24B5.5b"/>
        </source>
    </evidence>
    <sequence length="281" mass="30152" checksum="5AC053A38B9A114B" modified="2016-05-11" version="1">MKLYTHFILLVTFAVLASSSTIRDKRQNFTIKVSTKLCAPACQQSCSQQCQDNQTIANNADTNCISQCQAKCQARCGIQNGMGFQQSPATTTDAPIVIRLEITSGSSNSQCAPKCIQQCNNQCASQNQKTNQCANECNNQCANSCSPSSQTSSYSKCVSQCAEQCSGSNTSNNQQCQQQCQSNTCGQYQSTVSTTTTTPIIQIVLNSSVLNSGSECEPQCENSCQNQCQAQQQSQQQCAQACQTGCVAQCQPANVSCMPASTSTCQCQPNYSQCGNQCCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MB53</accession>
    <name>A0A131MB53_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_T20D4.3</name>
        <name evidence="4 6" type="ORF">T20D4.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309654.1">
        <property type="nucleotide sequence ID" value="NM_001322513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MB53"/>
    <dbReference type="SMR" id="A0A131MB53"/>
    <dbReference type="PaxDb" id="6239-T20D4.3"/>
    <dbReference type="GeneID" id="188639"/>
    <dbReference type="AGR" id="WB:WBGene00020609"/>
    <dbReference type="CTD" id="188639"/>
    <dbReference type="WormBase" id="T20D4.3a">
        <property type="protein sequence ID" value="CE51340"/>
        <property type="gene ID" value="WBGene00020609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020609">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1020:FF:000004">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1020:FF:000007">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1020">
        <property type="entry name" value="Peptide N glycanase, PAW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038680">
        <property type="entry name" value="PAW_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006588">
        <property type="entry name" value="Peptide_N_glycanase_PAW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48440:SF1">
        <property type="entry name" value="PAW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00613">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51398">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAW" evidence="3">
        <location>
            <begin position="60"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PAW" evidence="3">
        <location>
            <begin position="259"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="PAW" evidence="3">
        <location>
            <begin position="470"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CZR14579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="T20D4.3a"/>
        </source>
    </evidence>
    <sequence length="680" mass="78012" checksum="E28B3B8A3C0F2AA4" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H9F5</accession>
    <name>A0A168H9F5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dolichyl-phosphate beta-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">algn-5</name>
        <name evidence="1" type="ORF">CELE_H43I07.3</name>
        <name evidence="3" type="ORF">H43I07.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317828.1">
        <property type="nucleotide sequence ID" value="NM_001330840.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H9F5"/>
    <dbReference type="GeneID" id="178822"/>
    <dbReference type="KEGG" id="cel:CELE_H43I07.3"/>
    <dbReference type="AGR" id="WB:WBGene00019276"/>
    <dbReference type="CTD" id="178822"/>
    <dbReference type="WormBase" id="H43I07.3b">
        <property type="protein sequence ID" value="CE51596"/>
        <property type="gene ID" value="WBGene00019276"/>
        <property type="gene designation" value="algn-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019276">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A168H9F5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SAP35590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="H43I07.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="A0A168H9F5"/>
        </source>
    </evidence>
    <sequence length="177" mass="20276" checksum="CA1797756BA33190" modified="2016-07-06" version="1">MGVLHSSGKLILFADADGATKFADFENLEKEMLRTAGGEPLDESFPAVIVASRAHLEAESMAVRSVPRTILMLGFHLLVYTFAARTIKDTQCGFKLFTRSIAARIFPVLHIERWAFDVELIFLCERWTVPVKEVSVRWTEIEGSKITPIWSWLQMGRDLVLIWFRYTIGIWTDDQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1S7LE80</accession>
    <name>A0A1S7LE80_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C29E4.9</name>
        <name evidence="2" type="ORF">CELE_C29E4.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CEO42404.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001337279.1">
        <property type="nucleotide sequence ID" value="NM_001350363.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1S7LE80"/>
    <dbReference type="GeneID" id="183001"/>
    <dbReference type="KEGG" id="cel:CELE_C29E4.9"/>
    <dbReference type="AGR" id="WB:WBGene00016206"/>
    <dbReference type="CTD" id="183001"/>
    <dbReference type="WormBase" id="C29E4.9">
        <property type="protein sequence ID" value="CE51931"/>
        <property type="gene ID" value="WBGene00016206"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5778740at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016206">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013045988" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CEO42404.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C29E4.9"/>
        </source>
    </evidence>
    <sequence length="144" mass="15072" checksum="A2FC72B0824708DE" modified="2017-05-10" version="1">MIFFKYSIILSLTSIIPSLFGCMSTRTVGSIPALRNCPSCDVSTLSGSSFTPTSTQTPGTAYFLRGVDPANWCDVAQINCIPEDGSMQTVAINVIVDSVSTSLGSGCGSANSVANALLCSTGNVWTYNGRSDFTVECRVTIGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DQR1</accession>
    <name>A0A3B1DQR1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Centrosomal protein CEP104 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">cepr-104.2</name>
        <name evidence="4" type="ORF">C06A8.8</name>
        <name evidence="2" type="ORF">CELE_C06A8.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="VAY52113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355403.1">
        <property type="nucleotide sequence ID" value="NM_001368606.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1DQR1"/>
    <dbReference type="GeneID" id="182287"/>
    <dbReference type="AGR" id="WB:WBGene00015517"/>
    <dbReference type="CTD" id="182287"/>
    <dbReference type="WormBase" id="C06A8.8d">
        <property type="protein sequence ID" value="CE52745"/>
        <property type="gene ID" value="WBGene00015517"/>
        <property type="gene designation" value="cepr-104.2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015517">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1DQR1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VAY52113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C06A8.8d"/>
        </source>
    </evidence>
    <sequence length="102" mass="11335" checksum="6A54E8A626C76897" modified="2018-12-05" version="1">MSYIELDKGILLPLKSKPKMRETKTIVGLYDTDSEDEEILFSKEMLNRLRKREAVMKNPQLPTTSAITETIAIDTSCEKSAPVSSSSSSKQQSSVSPPLSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DR32</accession>
    <name>A0A3B1DR32_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Voltage-dependent calcium channel type A subunit alpha-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23 25" type="primary">unc-2</name>
        <name evidence="23" type="ORF">CELE_T02C5.5</name>
        <name evidence="25" type="ORF">T02C5.5</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355463.1">
        <property type="nucleotide sequence ID" value="NM_001368495.4"/>
    </dbReference>
    <dbReference type="SMR" id="A0A3B1DR32"/>
    <dbReference type="GeneID" id="180570"/>
    <dbReference type="AGR" id="WB:WBGene00006742"/>
    <dbReference type="CTD" id="180570"/>
    <dbReference type="WormBase" id="T02C5.5o">
        <property type="protein sequence ID" value="CE52764"/>
        <property type="gene ID" value="WBGene00006742"/>
        <property type="gene designation" value="unc-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006742">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1DR32">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042045">
        <property type="term" value="P:epithelial fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000043">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000059">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000068">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
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    <accession>A0A4V0INB7</accession>
    <name>A0A4V0INB7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TLDc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">tbc-7</name>
        <name evidence="12" type="ORF">C31H2.1</name>
        <name evidence="10" type="ORF">CELE_C31H2.1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VTW47499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360675.1">
        <property type="nucleotide sequence ID" value="NM_001373290.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V0INB7"/>
    <dbReference type="SMR" id="A0A4V0INB7"/>
    <dbReference type="GeneID" id="180784"/>
    <dbReference type="AGR" id="WB:WBGene00016292"/>
    <dbReference type="CTD" id="180784"/>
    <dbReference type="WormBase" id="C31H2.1c">
        <property type="protein sequence ID" value="CE53360"/>
        <property type="gene ID" value="WBGene00016292"/>
        <property type="gene designation" value="tbc-7"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10065050at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A4V0INB7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF122">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN SKYWALKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="8">
        <location>
            <begin position="57"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="9">
        <location>
            <begin position="355"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VTW47499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C31H2.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="A0A4V0INB7"/>
        </source>
    </evidence>
    <sequence length="537" mass="61365" checksum="0E9C56C91160B172" modified="2019-07-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V0IND1</accession>
    <name>A0A4V0IND1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">lgx-1</name>
        <name evidence="6" type="ORF">C54G7.3</name>
        <name evidence="4" type="ORF">CELE_C54G7.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VTW47550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360726.1">
        <property type="nucleotide sequence ID" value="NM_001373302.2"/>
    </dbReference>
    <dbReference type="SMR" id="A0A4V0IND1"/>
    <dbReference type="GeneID" id="180825"/>
    <dbReference type="AGR" id="WB:WBGene00002983"/>
    <dbReference type="CTD" id="180825"/>
    <dbReference type="WormBase" id="C54G7.3i">
        <property type="protein sequence ID" value="CE53232"/>
        <property type="gene ID" value="WBGene00002983"/>
        <property type="gene designation" value="lgx-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A4V0IND1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10974">
        <property type="entry name" value="CE4_CDA_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF11">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020915579" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="493"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="538"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="586"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="677"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="787"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="838"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="903"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="950"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1073"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1108"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VTW47550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C54G7.3i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A4V0IND1"/>
        </source>
    </evidence>
    <sequence length="1605" mass="174017" checksum="F0F2CA17CE43E1E5" modified="2019-07-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V0IND2</accession>
    <name>A0A4V0IND2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ligand-Gated ion Channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">lgc-41</name>
        <name evidence="17" type="ORF">C39B10.2</name>
        <name evidence="15" type="ORF">CELE_C39B10.2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VTW47509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360685.1">
        <property type="nucleotide sequence ID" value="NM_001373479.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V0IND2"/>
    <dbReference type="SMR" id="A0A4V0IND2"/>
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</entry>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VTW47570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360746.1">
        <property type="nucleotide sequence ID" value="NM_001373391.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V0ING2"/>
    <dbReference type="SMR" id="A0A4V0ING2"/>
    <dbReference type="GeneID" id="181093"/>
    <dbReference type="AGR" id="WB:WBGene00006942"/>
    <dbReference type="CTD" id="181093"/>
    <dbReference type="WormBase" id="F41D9.3f">
        <property type="protein sequence ID" value="CE53411"/>
        <property type="gene ID" value="WBGene00006942"/>
        <property type="gene designation" value="wrk-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A4V0ING2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002406">
        <property type="entry name" value="Wrapper/Rega-1/Klingon homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF20">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020623232" evidence="2">
        <location>
            <begin position="19"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="115"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="218"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VTW47570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F41D9.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A4V0ING2"/>
        </source>
    </evidence>
    <sequence length="446" mass="49698" checksum="59633322FA585321" modified="2019-07-31" version="1">MMKLVLLILGLLIASTSAQIRTKGGTLIAKEGESLTLRCEVEDPSVAIIWRKNTEVVAVDDEILDTYGGYEISMEGSTSVLTIKRVEPINSANYSCALAEPEVSVTFVIKVQVKPLVVISPDTGVYHARVGEKNLVITCHVKEGNPKPGVVWTKQFKAAKLPEDIKREHGGARIVITEVKKHHAGKYNCLAENIAGSDRATIDIHVAEPLQGEREEKPWVKNEDTFIPVRKNQNASFWCTYDGTPVPQVEWLFNGYKINFNDEKFKKTSETAQRLNGYSKSTLTVGDISEEAFGDYACRISNKLGSVTAVVHVSGRPGPPQLSFDESELTWTVRAFDKILEYQLCHRLENADHFLPEDCNSVRVKKSDNNGDDKWTHTIDLSTFLEHGNKYHVQLKARNALGWGSMAKDALHVELQRIEKEEAKGASIISIISSILVTLVTMYLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-10-13" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C8JQR2</accession>
    <name>C8JQR2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adapter protein unc-53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">unc-53</name>
        <name evidence="7" type="ORF">CELE_F45E10.1</name>
        <name evidence="9" type="ORF">F45E10.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nav/unc-53 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CBB16173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254273.1">
        <property type="nucleotide sequence ID" value="NM_001267344.3"/>
    </dbReference>
    <dbReference type="GeneID" id="174693"/>
    <dbReference type="AGR" id="WB:WBGene00006788"/>
    <dbReference type="CTD" id="174693"/>
    <dbReference type="WormBase" id="F45E10.1f">
        <property type="protein sequence ID" value="CE43986"/>
        <property type="gene ID" value="WBGene00006788"/>
        <property type="gene designation" value="unc-53"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161974at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006788">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C8JQR2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043057">
        <property type="term" value="P:backward locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016204">
        <property type="term" value="P:determination of muscle attachment site"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007617">
        <property type="term" value="P:mating behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008078">
        <property type="term" value="P:mesodermal cell migration"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045773">
        <property type="term" value="P:positive regulation of axon extension"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057568">
        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057126">
        <property type="entry name" value="NAV1-like_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25408">
        <property type="entry name" value="AAA_lid_NAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23092">
        <property type="entry name" value="Ubiquitin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neuron navigator 1-like ubiquitin-like" evidence="5">
        <location>
            <begin position="919"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="CortBP2/NAV1-like AAA+ ATPase lid" evidence="6">
        <location>
            <begin position="1196"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="849"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBB16173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F45E10.1f"/>
        </source>
    </evidence>
    <sequence length="1346" mass="148471" checksum="9E8F01D2032C3B9C" modified="2009-10-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT61</accession>
    <name>D3YT61_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell death protein 3 subunit p17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">ced-3</name>
        <name evidence="12" type="ORF">C48D1.2</name>
        <name evidence="10" type="ORF">CELE_C48D1.2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255709.1">
        <property type="nucleotide sequence ID" value="NM_001268780.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT61"/>
    <dbReference type="SMR" id="D3YT61"/>
    <dbReference type="MEROPS" id="C14.002"/>
    <dbReference type="PeptideAtlas" id="D3YT61"/>
    <dbReference type="GeneID" id="178272"/>
    <dbReference type="AGR" id="WB:WBGene00000417"/>
    <dbReference type="CTD" id="178272"/>
    <dbReference type="WormBase" id="C48D1.2b">
        <property type="protein sequence ID" value="CE44550"/>
        <property type="gene ID" value="WBGene00000417"/>
        <property type="gene designation" value="ced-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036904_5_2_1"/>
    <dbReference type="OrthoDB" id="6114029at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000417">
        <property type="expression patterns" value="Expressed in adult organism and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT61">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097194">
        <property type="term" value="P:execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="9">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="8">
        <location>
            <begin position="189"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBK19388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C48D1.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT61"/>
        </source>
    </evidence>
    <sequence length="287" mass="32514" checksum="1DCF6FBD00059E3C" modified="2010-04-20" version="1">MNFVDAPTISRVFDEKTMYRNFSSPRGMCLIINNEHFEQMPTRNGTKADKDNLTNLFRCMGYTVICKDNLTGRGMLLTIRDFAKHESHGDSAILVILSHGEENVIIGVDDIPISTHEIYDLLNAANAPRLANKPKIVFVQACRGERRDNGFPVLDSVDGVPAFLRRGWDNRDGPLFNFLGCVRPQVQQVWRKKPSQADILIAYATTAQYVSWRNSARGSWFIQAVCEVFSTHAKDMDVVELLTEVNKKVACGFQTSQGSNILKQMPEMTSRLLKKFYFWPEARNSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT63</accession>
    <name>D3YT63_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C48D1.9</name>
        <name evidence="1" type="ORF">CELE_C48D1.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255711.1">
        <property type="nucleotide sequence ID" value="NM_001268782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT63"/>
    <dbReference type="SMR" id="D3YT63"/>
    <dbReference type="GeneID" id="13198834"/>
    <dbReference type="AGR" id="WB:WBGene00194643"/>
    <dbReference type="CTD" id="13198834"/>
    <dbReference type="WormBase" id="C48D1.9b">
        <property type="protein sequence ID" value="CE44581"/>
        <property type="gene ID" value="WBGene00194643"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104323_0_0_1"/>
    <dbReference type="OrthoDB" id="10553654at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00194643">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT63">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C48D1.9b"/>
        </source>
    </evidence>
    <sequence length="159" mass="18955" checksum="AB27CCA442AC4EC6" modified="2010-04-20" version="1">MIPAAVVLFIWMKIRNSIRFHRESVKRRRHERKLKFLQTNRIRETILDQPTNEEIGQDLAKQFPIREGVIYKMKMRKELEKKYLAFRRLRLTQEMSNGALLQKSMNDKLDLPEQFTALELVCDAEQSIVEEANFHKDPEFVIGSIAMEYDIVKMDSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT64</accession>
    <name>D3YT64_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C48D1.9</name>
        <name evidence="1" type="ORF">CELE_C48D1.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255712.1">
        <property type="nucleotide sequence ID" value="NM_001268783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT64"/>
    <dbReference type="GeneID" id="13198834"/>
    <dbReference type="AGR" id="WB:WBGene00194643"/>
    <dbReference type="CTD" id="13198834"/>
    <dbReference type="WormBase" id="C48D1.9c">
        <property type="protein sequence ID" value="CE44643"/>
        <property type="gene ID" value="WBGene00194643"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104323_0_0_1"/>
    <dbReference type="OrthoDB" id="10553654at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00194643">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT64">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C48D1.9c"/>
        </source>
    </evidence>
    <sequence length="65" mass="7362" checksum="57A6D786B693CC3F" modified="2010-04-20" version="1">MSNGALLQKSMNDKLDLPEQFTALELVCDAEQSIVEEANFHKDPEFVIGSIAMEYDIVKMDSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT65</accession>
    <name>D3YT65_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Small integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F08A7.1</name>
        <name evidence="1 3" type="ORF">F08A7.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255959.1">
        <property type="nucleotide sequence ID" value="NM_001269030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT65"/>
    <dbReference type="GeneID" id="13211252"/>
    <dbReference type="AGR" id="WB:WBGene00045013"/>
    <dbReference type="CTD" id="13211252"/>
    <dbReference type="WormBase" id="F08A7.1b">
        <property type="protein sequence ID" value="CE44605"/>
        <property type="gene ID" value="WBGene00045013"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125139_0_0_1"/>
    <dbReference type="OrthoDB" id="10436621at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00045013">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT65">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F08A7.1b"/>
        </source>
    </evidence>
    <sequence length="25" mass="2872" checksum="66BF358A5AEEEE5D" modified="2010-04-20" version="1">MILCFCTCCCCNTIEKTKRSNKLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT69</accession>
    <name>D3YT69_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GATA-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">lin-66</name>
        <name evidence="4" type="ORF">B0513.1</name>
        <name evidence="2" type="ORF">CELE_B0513.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255768.1">
        <property type="nucleotide sequence ID" value="NM_001268839.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT69"/>
    <dbReference type="IntAct" id="D3YT69">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="D3YT69"/>
    <dbReference type="GeneID" id="178354"/>
    <dbReference type="AGR" id="WB:WBGene00001562"/>
    <dbReference type="CTD" id="178354"/>
    <dbReference type="WormBase" id="B0513.1b">
        <property type="protein sequence ID" value="CE44549"/>
        <property type="gene ID" value="WBGene00001562"/>
        <property type="gene designation" value="lin-66"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472696_0_0_1"/>
    <dbReference type="OrthoDB" id="5789077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001562">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT69">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040034">
        <property type="term" value="P:regulation of development, heterochronic"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36949:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36949">
        <property type="entry name" value="PROTEIN CBR-LIN-66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="B0513.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT69"/>
        </source>
    </evidence>
    <sequence length="211" mass="21882" checksum="997C31EC44DF72E7" modified="2010-04-20" version="1">MTPAATRSGSLWDSQSSLSQSGNSGDQWSPLFSPSTWSNNTNANPRLTSLTPLSSMNETLLSGVNYNSLLAMPPSAKNERSIGVQADDFLDRMSYNPIGRTGCTCQCQCGRGGAAIIGNTRGSSSRASGGSASPPSADGASQIDRFSPSNHAGSIGDRTLTAAALGVGLVDQQPAAPNHDGSANQPQRYYDPFGTADLLNGTRLNSLRIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT70</accession>
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        <submittedName>
            <fullName evidence="2">THO complex subunit 7 homolog</fullName>
        </submittedName>
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        <name evidence="2 4" type="primary">thoc-7</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255766.1">
        <property type="nucleotide sequence ID" value="NM_001268837.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT70"/>
    <dbReference type="GeneID" id="178353"/>
    <dbReference type="AGR" id="WB:WBGene00007195"/>
    <dbReference type="CTD" id="178353"/>
    <dbReference type="WormBase" id="B0513.2b">
        <property type="protein sequence ID" value="CE44713"/>
        <property type="gene ID" value="WBGene00007195"/>
        <property type="gene designation" value="thoc-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087727_0_0_1"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007195">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT70">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000347">
        <property type="term" value="C:THO complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="B0513.2b"/>
        </source>
    </evidence>
    <sequence length="24" mass="2665" checksum="F94B42556563E64F" modified="2010-04-20" version="1">MSNPGEDDDAASVTEKQQEDDVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT72</accession>
    <name>D3YT72_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">B0513.4</name>
        <name evidence="1" type="ORF">CELE_B0513.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001268833.3"/>
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    <dbReference type="WormBase" id="B0513.4b">
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        <property type="gene ID" value="WBGene00007196"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160888_0_0_1"/>
    <dbReference type="OrthoDB" id="5800366at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007196">
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="B0513.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT72"/>
        </source>
    </evidence>
    <sequence length="37" mass="4032" checksum="396A4EEB290EA870" modified="2010-04-20" version="1">MAARIQGTNIKEASIIGFNMVLEKQPLCVCCSPNTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT78</accession>
    <name>D3YT78_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AF-9 ANC1 homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rsd-2</name>
        <name evidence="3" type="ORF">CELE_F52G2.2</name>
        <name evidence="5" type="ORF">F52G2.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255750.1">
        <property type="nucleotide sequence ID" value="NM_001268821.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT78"/>
    <dbReference type="SMR" id="D3YT78"/>
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        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="D3YT78"/>
    <dbReference type="GeneID" id="178322"/>
    <dbReference type="AGR" id="WB:WBGene00004681"/>
    <dbReference type="CTD" id="178322"/>
    <dbReference type="WormBase" id="F52G2.2c">
        <property type="protein sequence ID" value="CE44573"/>
        <property type="gene ID" value="WBGene00004681"/>
        <property type="gene designation" value="rsd-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006438_0_0_1"/>
    <dbReference type="OrthoDB" id="5879648at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004681">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT78">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040930">
        <property type="entry name" value="AF-9_AHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17793">
        <property type="entry name" value="AHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AF-9 ANC1 homology" evidence="2">
        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBK19451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F52G2.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT78"/>
        </source>
    </evidence>
    <sequence length="417" mass="47197" checksum="92EAA2D22DCEF6DA" modified="2010-04-20" version="1">METRSNAGTSVSSVDRKEVGVVMKKVDKNTQIVYLSGQKAAAIHHWNTHSQSTIVGNSYIFMYRPIEVHKATHYAPFEITQVVEILNTENHGRVDRSEFSSLFTFDLCNVDQRYVERLAFGEALVLRSNDVGHVVMASNVKTPLNPSMTAVEVCQTYKGKRESENLVGYCRLVYGKVPREIVDGHFSDQFVSAYYFELHEILATSNAYIVRNENLDRRNLRGNTIEEVRDDISIQKRIAHMNFGQNEQQQQQSSLSSRGPTRPYSPVGSYQSSHQNFDNRSAAHNGDGRSTSQSHHSAGGSMNHQNFYQPPVYQSSSSQQSYQPRYNGAPSGPLPPPSSQSSFNGAPAPPHYSEMSNDYNRMVRKLAELTDTAAQMIINNDIRQQIKNISPDLLDDLERNIDACQREKRHYYEKYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT79</accession>
    <name>D3YT79_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, CCHC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_JC8.7</name>
        <name evidence="6 8" type="ORF">JC8.7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255716.1">
        <property type="nucleotide sequence ID" value="NM_001268787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT79"/>
    <dbReference type="SMR" id="D3YT79"/>
    <dbReference type="GeneID" id="186815"/>
    <dbReference type="AGR" id="WB:WBGene00010439"/>
    <dbReference type="CTD" id="186815"/>
    <dbReference type="WormBase" id="JC8.7b">
        <property type="protein sequence ID" value="CE44696"/>
        <property type="gene ID" value="WBGene00010439"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076705_0_0_1"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010439">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT79">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019361">
        <property type="entry name" value="HPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386:SF1">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10228">
        <property type="entry name" value="HPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBK19456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="JC8.7b"/>
        </source>
    </evidence>
    <sequence length="245" mass="27860" checksum="2CFB5F4CDC38BB39" modified="2010-04-20" version="1">MLDREMTDLPEMQTFMKCSHGRYAFWRDKPNDKKPVIVFMDLKTIPDLSVVGNEIRHAILDFCTRCSKCIDCSAKSKAANSKIQSFFTPSKISSEVKEVLKHREKTTVRGISGPGMLIDVVPTGNSGKKNKKNERTGYRDLSKNAYCINIEHLVRSLRLCQTKEQEEKVLDFVYGLMNEINICNDEGDFGNGLELGHILFLANMKAVADPMMITLHIAYKNLHRPDFAKILDLTLSLRDQQEEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT80</accession>
    <name>D3YT80_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">nspg-9</name>
        <name evidence="1" type="ORF">CELE_LLC1.2</name>
        <name evidence="3" type="ORF">LLC1.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255809.1">
        <property type="nucleotide sequence ID" value="NM_001268880.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT80"/>
    <dbReference type="PeptideAtlas" id="D3YT80"/>
    <dbReference type="GeneID" id="178386"/>
    <dbReference type="AGR" id="WB:WBGene00010793"/>
    <dbReference type="CTD" id="178386"/>
    <dbReference type="WormBase" id="LLC1.2b">
        <property type="protein sequence ID" value="CE44649"/>
        <property type="gene ID" value="WBGene00010793"/>
        <property type="gene designation" value="nspg-9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1042925_0_0_1"/>
    <dbReference type="OrthoDB" id="5823675at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010793">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT80">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="LLC1.2b"/>
        </source>
    </evidence>
    <sequence length="23" mass="2545" checksum="3C2D5B8B5C7AD2C7" modified="2010-04-20" version="1">MPDTVEQKDGQLVSVDGVWLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT85</accession>
    <name>D3YT85_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">dmd-6</name>
        <name evidence="2" type="ORF">CELE_F13G11.1</name>
        <name evidence="4" type="ORF">F13G11.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255816.1">
        <property type="nucleotide sequence ID" value="NM_001268887.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT85"/>
    <dbReference type="PeptideAtlas" id="D3YT85"/>
    <dbReference type="GeneID" id="178392"/>
    <dbReference type="KEGG" id="cel:CELE_F13G11.1"/>
    <dbReference type="AGR" id="WB:WBGene00007058"/>
    <dbReference type="CTD" id="178392"/>
    <dbReference type="WormBase" id="F13G11.1c">
        <property type="protein sequence ID" value="CE44552"/>
        <property type="gene ID" value="WBGene00007058"/>
        <property type="gene designation" value="dmd-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048941_0_0_1"/>
    <dbReference type="OrthoDB" id="5856755at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007058">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT85">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F13G11.1c"/>
        </source>
    </evidence>
    <sequence length="338" mass="36806" checksum="8D646F3BE76EDD85" modified="2010-04-20" version="1">MDSETRTSSTTPITRSNSTMPTANGLEGRSGSLGHMTVMSYDIWKAKCASERKRLEEERLTKPELFTRSPSPGPMRKRAHTFVAPPTIHTPDIPVVAAKKMSLDEKVKGKFITLPTIPAMRIFVNEEDEDVKPVTQMQLAQPIALTPSPQMSLASTLAQIPMSTPVCMPSMITPTSFLDIPSTSSPMLPFQISTTTSPMLQRQTPILTPQMSPFKPVGVATPQPPALSNLSAGQELSSFILHSVVLQAQQAQQKTAQQLIPTSMPSELESTLSLLRLQQSSLGDLIKLSGIQLPTLPTTQPMLTPQMPTLPMMQKALPTVLPGSFQPFLQPTLFTNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT86</accession>
    <name>D3YT86_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">dmd-6</name>
        <name evidence="1" type="ORF">CELE_F13G11.1</name>
        <name evidence="3" type="ORF">F13G11.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255817.1">
        <property type="nucleotide sequence ID" value="NM_001268888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT86"/>
    <dbReference type="GeneID" id="178392"/>
    <dbReference type="AGR" id="WB:WBGene00007058"/>
    <dbReference type="CTD" id="178392"/>
    <dbReference type="WormBase" id="F13G11.1d">
        <property type="protein sequence ID" value="CE44560"/>
        <property type="gene ID" value="WBGene00007058"/>
        <property type="gene designation" value="dmd-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048941_0_0_1"/>
    <dbReference type="OrthoDB" id="5856755at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007058">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT86">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F13G11.1d"/>
        </source>
    </evidence>
    <sequence length="319" mass="34752" checksum="4DFE59CDD6850103" modified="2010-04-20" version="1">MPTANGLEGRSGSLGHMTVMSYDIWKAKCASERKRLEEERLTKPELFTRSPSPGPMRKRAHTFVAPPTIHTPDIPVVAAKKMSLDEKVKGKFITLPTIPAMRIFVNEEDEDVKPVTQMQLAQPIALTPSPQMSLASTLAQIPMSTPVCMPSMITPTSFLDIPSTSSPMLPFQISTTTSPMLQRQTPILTPQMSPFKPVGVATPQPPALSNLSAGQELSSFILHSVVLQAQQAQQKTAQQLIPTSMPSELESTLSLLRLQQSSLGDLIKLSGIQLPTLPTTQPMLTPQMPTLPMMQKALPTVLPGSFQPFLQPTLFTNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT87</accession>
    <name>D3YT87_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GSKIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C06A12.3</name>
        <name evidence="3" type="ORF">CELE_C06A12.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSKIP family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255954.1">
        <property type="nucleotide sequence ID" value="NM_001269025.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT87"/>
    <dbReference type="SMR" id="D3YT87"/>
    <dbReference type="PeptideAtlas" id="D3YT87"/>
    <dbReference type="GeneID" id="178529"/>
    <dbReference type="AGR" id="WB:WBGene00007357"/>
    <dbReference type="CTD" id="178529"/>
    <dbReference type="WormBase" id="C06A12.3b">
        <property type="protein sequence ID" value="CE44661"/>
        <property type="gene ID" value="WBGene00007357"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079731_0_0_1"/>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007357">
        <property type="expression patterns" value="Expressed in material anatomical entity and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT87">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037395">
        <property type="entry name" value="GSKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490:SF4">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="2">
        <location>
            <begin position="43"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBK19363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C06A12.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT87"/>
        </source>
    </evidence>
    <sequence length="153" mass="17166" checksum="B609CC7044F616B4" modified="2010-04-20" version="1">MISPKMSIPKTPISLEEIADMNRKRHEVEGGVIPSDDDVGPLELEAIAAVHELAHEVQDISVSEMLPRTSDLIFVNVKTQEGSPYTLELTMKGWRIASSHTDCMNGDYTKISLHTKYYRNARELLKFISPDHATRFNECVAQKLSKLAEVAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT88</accession>
    <name>D3YT88_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GSKIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C06A12.3</name>
        <name evidence="3" type="ORF">CELE_C06A12.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSKIP family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255955.1">
        <property type="nucleotide sequence ID" value="NM_001269026.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT88"/>
    <dbReference type="SMR" id="D3YT88"/>
    <dbReference type="PeptideAtlas" id="D3YT88"/>
    <dbReference type="GeneID" id="178529"/>
    <dbReference type="AGR" id="WB:WBGene00007357"/>
    <dbReference type="CTD" id="178529"/>
    <dbReference type="WormBase" id="C06A12.3c">
        <property type="protein sequence ID" value="CE44639"/>
        <property type="gene ID" value="WBGene00007357"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1714935_0_0_1"/>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007357">
        <property type="expression patterns" value="Expressed in material anatomical entity and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT88">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037395">
        <property type="entry name" value="GSKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490:SF4">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="2">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBK19364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C06A12.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT88"/>
        </source>
    </evidence>
    <sequence length="133" mass="14983" checksum="B0DC656061737B34" modified="2010-04-20" version="1">MNRKRHEVEGGVIPSDDDVGPLELEAIAAVHELAHEVQDISVSEMLPRTSDLIFVNVKTQEGSPYTLELTMKGWRIASSHTDCMNGDYTKISLHTKYYRNARELLKFISPDHATRFNECVAQKLSKLAEVAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT91</accession>
    <name>D3YT91_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rga-5</name>
        <name evidence="3" type="ORF">CELE_H08M01.2</name>
        <name evidence="5" type="ORF">H08M01.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255759.1">
        <property type="nucleotide sequence ID" value="NM_001268830.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT91"/>
    <dbReference type="SMR" id="D3YT91"/>
    <dbReference type="GeneID" id="178348"/>
    <dbReference type="AGR" id="WB:WBGene00010374"/>
    <dbReference type="CTD" id="178348"/>
    <dbReference type="WormBase" id="H08M01.2c">
        <property type="protein sequence ID" value="CE44621"/>
        <property type="gene ID" value="WBGene00010374"/>
        <property type="gene designation" value="rga-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004268_0_0_1"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010374">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT91">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051978">
        <property type="entry name" value="Rho-GAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="340"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBK19454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="H08M01.2c"/>
        </source>
    </evidence>
    <sequence length="533" mass="59191" checksum="40AB90838742AA26" modified="2010-04-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT92</accession>
    <name>D3YT92_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rga-5</name>
        <name evidence="2" type="ORF">CELE_H08M01.2</name>
        <name evidence="4" type="ORF">H08M01.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255760.1">
        <property type="nucleotide sequence ID" value="NM_001268831.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT92"/>
    <dbReference type="SMR" id="D3YT92"/>
    <dbReference type="GeneID" id="178348"/>
    <dbReference type="AGR" id="WB:WBGene00010374"/>
    <dbReference type="CTD" id="178348"/>
    <dbReference type="WormBase" id="H08M01.2d">
        <property type="protein sequence ID" value="CE44576"/>
        <property type="gene ID" value="WBGene00010374"/>
        <property type="gene designation" value="rga-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004268_0_0_1"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010374">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT92">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051978">
        <property type="entry name" value="Rho-GAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="31"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="H08M01.2d"/>
        </source>
    </evidence>
    <sequence length="224" mass="25076" checksum="E23A216A999A46F4" modified="2010-04-20" version="1">MKNKSATHDLSTSLINYPASTSTQGVIAANETLETLCSKSPSQIPIYLEKCIQFIEQNGGFEQEGLYRVPGNQTHLAEVEKRFLKYGEFDVSSFDTPVHVAATALKSFFSCLPESLIPTAYHLRWKQIMMVSDDIKKIDGIRDALAILPVSNQKVLQYLVTHLTKVSCSPKTVMNSNNLSKVWTPTLFRPVFASYEELSSGIIAFQLALEMLIFNSHSLFNQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT95</accession>
    <name>D3YT95_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">qars-1</name>
        <name evidence="15" type="ORF">CELE_Y41E3.4</name>
        <name evidence="17" type="ORF">Y41E3.4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255844.1">
        <property type="nucleotide sequence ID" value="NM_001268915.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT95"/>
    <dbReference type="SMR" id="D3YT95"/>
    <dbReference type="PeptideAtlas" id="D3YT95"/>
    <dbReference type="GeneID" id="178415"/>
    <dbReference type="AGR" id="WB:WBGene00001336"/>
    <dbReference type="CTD" id="178415"/>
    <dbReference type="WormBase" id="Y41E3.4b">
        <property type="protein sequence ID" value="CE44635"/>
        <property type="gene ID" value="WBGene00001336"/>
        <property type="gene designation" value="qars-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001336">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT95">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000008">
        <property type="entry name" value="probable glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="43"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="345"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="14">
        <location>
            <begin position="460"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBK19497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="Y41E3.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT95"/>
        </source>
    </evidence>
    <sequence length="560" mass="64067" checksum="7204FBAE63EDF912" modified="2010-04-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT96</accession>
    <name>D3YT96_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">qars-1</name>
        <name evidence="14" type="ORF">CELE_Y41E3.4</name>
        <name evidence="16" type="ORF">Y41E3.4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001427154.1">
        <property type="nucleotide sequence ID" value="NM_001440220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT96"/>
    <dbReference type="SMR" id="D3YT96"/>
    <dbReference type="PeptideAtlas" id="D3YT96"/>
    <dbReference type="GeneID" id="178415"/>
    <dbReference type="AGR" id="WB:WBGene00001336"/>
    <dbReference type="CTD" id="178415"/>
    <dbReference type="WormBase" id="Y41E3.4c">
        <property type="protein sequence ID" value="CE44672"/>
        <property type="gene ID" value="WBGene00001336"/>
        <property type="gene designation" value="qars-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001336">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT96">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000008">
        <property type="entry name" value="probable glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="9"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="201"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="316"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBK19498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="Y41E3.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT96"/>
        </source>
    </evidence>
    <sequence length="416" mass="47852" checksum="BD81894BB6DA00D5" modified="2010-04-20" version="1">MRGFEVQLSPWRERPIEENIQLFEDMKNGKFDEGEATLRLKLTLEEGKVDPVAYRIKYVPHHRTGNQWCIYPTYDYTHCLCDSIENITHSLCTKEFQSRRSSYYWLCNALDIYCPVQWEYGRLNVNYTVVSKRKILKLITTKTVNDWDDPRLFTLTALRRRGIPSEAINRFVAKLGLTMSQMVIDPHVLDATVRDYLNIHAPRTMAVLEGLKLTIENFSELNLPSSVDVPDFPSDPTDPRKHSVSVDREIFIEKSDYKPDDSDKSFRRLTPKQAVGLKHIGLVLRFVKEVKDAEGHVTEVVVKAEKLSEKDKPKAFIHWVAKPVSCEVRLYDRLFKSKNPEDAQLVPGGFLSDINPDSLTVVYNALIDQSIAKSKVYDRFQFERIGFFCVDRDSTSSTLVFNRTVMLKDGGASGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT98</accession>
    <name>D3YT98_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y41E3.7</name>
        <name evidence="4 6" type="ORF">Y41E3.7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255846.1">
        <property type="nucleotide sequence ID" value="NM_001268917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT98"/>
    <dbReference type="SMR" id="D3YT98"/>
    <dbReference type="PeptideAtlas" id="D3YT98"/>
    <dbReference type="GeneID" id="178416"/>
    <dbReference type="AGR" id="WB:WBGene00012765"/>
    <dbReference type="CTD" id="178416"/>
    <dbReference type="WormBase" id="Y41E3.7e">
        <property type="protein sequence ID" value="CE44644"/>
        <property type="gene ID" value="WBGene00012765"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048443_0_0_1"/>
    <dbReference type="OrthoDB" id="5839451at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012765">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT98">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.680:FF:000006">
        <property type="entry name" value="Acyl-CoA binding domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.680:FF:000011">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052269">
        <property type="entry name" value="Golgi-PI4KB_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973:SF12">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13897">
        <property type="entry name" value="GOLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="69"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBK19500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y41E3.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT98"/>
        </source>
    </evidence>
    <sequence length="234" mass="26154" checksum="D95DDD2278B9ED6A" modified="2010-04-20" version="1">MSQVYAQQSTTPNGAEMNPEESHQHQIRRDDDSDVSDDEAGEDLPSNPAISPASLWNRQDINEFKANIKKDGHEGIIKVGHGETVTVRVPTHENGSCLFWEFATDHYDIGFGVYFEWTVADSNQVSVHVSESDDEEDYDEALEAEQAEAGGGGGGAAGQGGPGDVEAGAMQTRRVDPNKPRQDEIIPVYRRDCHEEVYAGSHRYPGRGIYLLKFDNSYSLWRSKTLYYRVYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT99</accession>
    <name>D3YT99_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FANCD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">fcd-2</name>
        <name evidence="7" type="ORF">CELE_Y41E3.9</name>
        <name evidence="9" type="ORF">Y41E3.9</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255849.1">
        <property type="nucleotide sequence ID" value="NM_001268920.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT99"/>
    <dbReference type="SMR" id="D3YT99"/>
    <dbReference type="PeptideAtlas" id="D3YT99"/>
    <dbReference type="GeneID" id="178418"/>
    <dbReference type="AGR" id="WB:WBGene00012767"/>
    <dbReference type="CTD" id="178418"/>
    <dbReference type="WormBase" id="Y41E3.9b">
        <property type="protein sequence ID" value="CE44662"/>
        <property type="gene ID" value="WBGene00012767"/>
        <property type="gene designation" value="fcd-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252446_0_0_1"/>
    <dbReference type="OrthoDB" id="27031at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012767">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT99">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090329">
        <property type="term" value="P:regulation of DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBK19501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y41E3.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT99"/>
        </source>
    </evidence>
    <sequence length="852" mass="96814" checksum="5194E81E5DF3D6B1" modified="2010-04-20" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-01" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>G5ECX0-2</accession>
    <name>LPLT2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Isoform b of Latrophilin-like protein LAT-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">lat-2</name>
        <name type="ORF">B0286.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2003-09" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular and evolutionary characterization of family B G-protein coupled receptors in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mastwal S.S."/>
                <person name="Yu D."/>
                <person name="Hedgecock E.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2007" name="Int. J. Parasitol." volume="37" first="1577" last="1588">
            <title>The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Guest M."/>
                <person name="Bull K."/>
                <person name="Walker R.J."/>
                <person name="Amliwala K."/>
                <person name="O'Connor V."/>
                <person name="Harder A."/>
                <person name="Holden-Dye L."/>
                <person name="Hopper N.A."/>
            </authorList>
            <dbReference type="PubMed" id="17583712"/>
            <dbReference type="DOI" id="10.1016/j.ijpara.2007.05.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2009" name="Dev. Cell" volume="17" first="494" last="504">
            <title>Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo.</title>
            <authorList>
                <person name="Langenhan T."/>
                <person name="Promel S."/>
                <person name="Mestek L."/>
                <person name="Esmaeili B."/>
                <person name="Waller-Evans H."/>
                <person name="Hennig C."/>
                <person name="Kohara Y."/>
                <person name="Avery L."/>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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            <strain evidence="3">Bristol N2</strain>
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        <citation type="submission" date="2003-09" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular and Evolutionary Characterization of family B G-protein coupled receptors in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mastwal S.S."/>
                <person name="Yu D."/>
                <person name="Hedgecock E.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
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        <citation type="journal article" date="2010" name="Development" volume="137" first="3663" last="3673">
            <title>The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons in C. elegans.</title>
            <authorList>
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                <person name="Wong L."/>
                <person name="Najarro E.H."/>
                <person name="Ackley B.D."/>
                <person name="Garriga G."/>
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        <scope>TISSUE SPECIFICITY</scope>
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        <citation type="journal article" date="2012" name="J. Neurosci." volume="32" first="4196" last="4211">
            <title>Caenorhabditis elegans flamingo cadherin fmi-1 regulates GABAergic neuronal development.</title>
            <authorList>
                <person name="Najarro E.H."/>
                <person name="Wong L."/>
                <person name="Zhen M."/>
                <person name="Carpio E.P."/>
                <person name="Goncharov A."/>
                <person name="Garriga G."/>
                <person name="Lundquist E.A."/>
                <person name="Jin Y."/>
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            <title>C. elegans fmi-1/flamingo and Wnt pathway components interact genetically to control the anteroposterior neurite growth of the VD GABAergic neurons.</title>
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        <citation type="journal article" date="2017" name="Nat. Neurosci." volume="20" first="1350" last="1360">
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Bristol N2</strain>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2003-09" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular and Evolutionary Characterization of family B G-protein coupled receptors in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mastwal S.S."/>
                <person name="Yu D."/>
                <person name="Hedgecock E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
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    <reference evidence="1" key="3">
        <citation type="journal article" date="2010" name="Development" volume="137" first="3663" last="3673">
            <title>The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons in C. elegans.</title>
            <authorList>
                <person name="Steimel A."/>
                <person name="Wong L."/>
                <person name="Najarro E.H."/>
                <person name="Ackley B.D."/>
                <person name="Garriga G."/>
                <person name="Hutter H."/>
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        <scope>FUNCTION</scope>
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        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
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        <citation type="journal article" date="2012" name="J. Neurosci." volume="32" first="4196" last="4211">
            <title>Caenorhabditis elegans flamingo cadherin fmi-1 regulates GABAergic neuronal development.</title>
            <authorList>
                <person name="Najarro E.H."/>
                <person name="Wong L."/>
                <person name="Zhen M."/>
                <person name="Carpio E.P."/>
                <person name="Goncharov A."/>
                <person name="Garriga G."/>
                <person name="Lundquist E.A."/>
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        <scope>FUNCTION</scope>
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        <citation type="journal article" date="2013" name="Dev. Biol." volume="377" first="224" last="235">
            <title>C. elegans fmi-1/flamingo and Wnt pathway components interact genetically to control the anteroposterior neurite growth of the VD GABAergic neurons.</title>
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                <person name="Ackley B.D."/>
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        <citation type="journal article" date="2017" name="Nat. Neurosci." volume="20" first="1350" last="1360">
            <title>Glia initiate brain assembly through noncanonical Chimaerin-Furin axon guidance in C. elegans.</title>
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                <person name="Rapti G."/>
                <person name="Li C."/>
                <person name="Shan A."/>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Bristol N2</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2015" name="Biochem. Biophys. Res. Commun." volume="459" first="154" last="160">
            <title>Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans.</title>
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                <person name="Yamanaka K."/>
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        <scope>TISSUE SPECIFICITY</scope>
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    <comment type="alternative products">
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        <isoform>
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        <source>
            <dbReference type="WormBase" id="C05C10.6b"/>
        </source>
    </evidence>
    <sequence length="858" mass="93640" checksum="C481089DCA2F9FE4" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-02-10" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZZ2-3</accession>
    <name>HLH30_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Helix-loop-helix protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hlh-30</name>
        <name evidence="5" type="ORF">W02C12.3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2009" name="Cell" volume="138" first="314" last="327">
            <title>A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors.</title>
            <authorList>
                <person name="Grove C.A."/>
                <person name="De Masi F."/>
                <person name="Barrasa M.I."/>
                <person name="Newburger D.E."/>
                <person name="Alkema M.J."/>
                <person name="Bulyk M.L."/>
                <person name="Walhout A.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="19632181"/>
            <dbReference type="DOI" id="10.1016/j.cell.2009.04.058"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Nat. Cell Biol." volume="15" first="668" last="676">
            <title>MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.</title>
            <authorList>
                <person name="O'Rourke E.J."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="23604316"/>
            <dbReference type="DOI" id="10.1038/ncb2741"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2013" name="Nat. Commun." volume="4" first="2267" last="2267">
            <title>The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lapierre L.R."/>
                <person name="De Magalhaes Filho C.D."/>
                <person name="McQuary P.R."/>
                <person name="Chu C.C."/>
                <person name="Visvikis O."/>
                <person name="Chang J.T."/>
                <person name="Gelino S."/>
                <person name="Ong B."/>
                <person name="Davis A.E."/>
                <person name="Irazoqui J.E."/>
                <person name="Dillin A."/>
                <person name="Hansen M."/>
            </authorList>
            <dbReference type="PubMed" id="23925298"/>
            <dbReference type="DOI" id="10.1038/ncomms3267"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2014" name="Immunity" volume="40" first="896" last="909">
            <title>Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.</title>
            <authorList>
                <person name="Visvikis O."/>
                <person name="Ihuegbu N."/>
                <person name="Labed S.A."/>
                <person name="Luhachack L.G."/>
                <person name="Alves A.M."/>
                <person name="Wollenberg A.C."/>
                <person name="Stuart L.M."/>
                <person name="Stormo G.D."/>
                <person name="Irazoqui J.E."/>
            </authorList>
            <dbReference type="PubMed" id="24882217"/>
            <dbReference type="DOI" id="10.1016/j.immuni.2014.05.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2016" name="Cell Rep." volume="15" first="1728" last="1742">
            <title>An evolutionarily conserved PLC-PKD-TFEB pathway for host defense.</title>
            <authorList>
                <person name="Najibi M."/>
                <person name="Labed S.A."/>
                <person name="Visvikis O."/>
                <person name="Irazoqui J.E."/>
            </authorList>
            <dbReference type="PubMed" id="27184844"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.04.052"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="1" key="7">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10944" last="10944">
            <title>Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.</title>
            <authorList>
                <person name="Nakamura S."/>
                <person name="Karalay O."/>
                <person name="Jaeger P.S."/>
                <person name="Horikawa M."/>
                <person name="Klein C."/>
                <person name="Nakamura K."/>
                <person name="Latza C."/>
                <person name="Templer S.E."/>
                <person name="Dieterich C."/>
                <person name="Antebi A."/>
            </authorList>
            <dbReference type="PubMed" id="27001890"/>
            <dbReference type="DOI" id="10.1038/ncomms10944"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="8">
        <citation type="journal article" date="2017" name="Autophagy" volume="13" first="371" last="385">
            <title>HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.</title>
            <authorList>
                <person name="Chen H.D."/>
                <person name="Kao C.Y."/>
                <person name="Liu B.Y."/>
                <person name="Huang S.W."/>
                <person name="Kuo C.J."/>
                <person name="Ruan J.W."/>
                <person name="Lin Y.H."/>
                <person name="Huang C.R."/>
                <person name="Chen Y.H."/>
                <person name="Wang H.D."/>
                <person name="Aroian R.V."/>
                <person name="Chen C.S."/>
            </authorList>
            <dbReference type="PubMed" id="27875098"/>
            <dbReference type="DOI" id="10.1080/15548627.2016.1256933"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="14337" last="14337">
            <title>Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.</title>
            <authorList>
                <person name="Kumsta C."/>
                <person name="Chang J.T."/>
                <person name="Schmalz J."/>
                <person name="Hansen M."/>
            </authorList>
            <dbReference type="PubMed" id="28198373"/>
            <dbReference type="DOI" id="10.1038/ncomms14337"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.</title>
            <authorList>
                <person name="Blazie S.M."/>
                <person name="Takayanagi-Kiya S."/>
                <person name="McCulloch K.A."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="34323215"/>
            <dbReference type="DOI" id="10.7554/elife.68336"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KZZ2-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_060891"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060892"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060893 VSP_060895"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_060895 VSP_060894"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-6</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_060892 VSP_060895"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060893"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_060897 VSP_060892 VSP_060896"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-1</id>
            <name evidence="5">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060895"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_060894"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_500461.1">
        <property type="nucleotide sequence ID" value="NM_068060.5"/>
    </dbReference>
    <dbReference type="WormBase" id="W02C12.3b">
        <property type="protein sequence ID" value="CE28499"/>
        <property type="gene ID" value="WBGene00020930"/>
        <property type="gene designation" value="hlh-30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="W02C12.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="W02C12.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="W02C12.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="W02C12.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="W02C12.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="W02C12.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="W02C12.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="W02C12.3h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="W02C12.3i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="W02C12.3j"/>
        </source>
    </evidence>
    <sequence length="499" mass="53987" checksum="585C614BB06CBFF7" modified="2012-03-21" version="1">MIRQLNSPGGGGGLGLNNPRAQQPPGAQQQQQPQQAQQQFYDDEPYQANASQFRFGAGKSMEQRRETGNLIPIAQRSMGSTSTPFGSAPTQSYFGGGSSGAALSSPRKMQQTHQMLFGNIQPPRGSPPSDGSDKIHRFGESPTPGGVGGVFGTEMTIGGEKTMSMARPIPGASSRAGSGHSGSPITIPNAMSNNFRQVVSSSAPTSSIDIEKMIGAVSNGGGNSGGDNDPEDYYRDRRKKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQKDREQAMKTQQQQKSLESTAHKYADRVKELEEMLARQGVQVPPSHLPPIPKVIERPIKQEIDESPPNHTPTGSFVSSSGFLSEVTNNTAAMQITSPNDSRPNNFMNNSAPSDSFFSVGSASPPDYRTSSGTASWKLPGSNAFSDLMMDDLNPMMNGDPLISSAGAHPSPHFHSSQMSPDIHWDASGFSPDPINTQQSNSGHYHMDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>O18218</accession>
    <accession>O18217</accession>
    <name>O18218_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nanos-type domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="4 6" type="primary">nos-3</name>
        <name evidence="4" type="ORF">CELE_Y53C12B.3</name>
        <name evidence="6" type="ORF">Y53C12B.3</name>
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    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nanos family.</text>
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    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAB16493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T27136"/>
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        <property type="nucleotide sequence ID" value="NM_063701.5"/>
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    <dbReference type="AlphaFoldDB" id="O18218"/>
    <dbReference type="SMR" id="O18218"/>
    <dbReference type="DIP" id="DIP-26678N"/>
    <dbReference type="IntAct" id="O18218">
        <property type="interactions" value="4"/>
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    <dbReference type="PeptideAtlas" id="O18218"/>
    <dbReference type="GeneID" id="174535"/>
    <dbReference type="UCSC" id="Y53C12B.3a">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00003785"/>
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    <dbReference type="WormBase" id="Y53C12B.3a">
        <property type="protein sequence ID" value="CE19224"/>
        <property type="gene ID" value="WBGene00003785"/>
        <property type="gene designation" value="nos-3"/>
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Nanos_sf"/>
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        <property type="entry name" value="Znf_nanos-typ"/>
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    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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            <begin position="696"/>
            <end position="750"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="41"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
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        <location>
            <begin position="227"/>
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        </location>
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        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
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        <location>
            <begin position="281"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="560"/>
            <end position="597"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
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        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="831"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB16493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y53C12B.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="O18218"/>
        </source>
    </evidence>
    <sequence length="867" mass="95623" checksum="A20C21D2E6D06F39" modified="1998-11-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>O18221</accession>
    <name>O18221_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
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        <name evidence="7 9" type="primary">tag-273</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAB16496.4"/>
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    </dbReference>
    <dbReference type="PIR" id="E88901">
        <property type="entry name" value="E88901"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023516.1">
        <property type="nucleotide sequence ID" value="NM_001028345.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O18221"/>
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    <dbReference type="PeptideAtlas" id="O18221"/>
    <dbReference type="GeneID" id="178388"/>
    <dbReference type="KEGG" id="cel:CELE_Y57G11A.1"/>
    <dbReference type="UCSC" id="Y57G11A.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013289"/>
    <dbReference type="CTD" id="178388"/>
    <dbReference type="WormBase" id="Y57G11A.1a">
        <property type="protein sequence ID" value="CE14908"/>
        <property type="gene ID" value="WBGene00013289"/>
        <property type="gene designation" value="tag-273"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032850_0_0_1"/>
    <dbReference type="OrthoDB" id="1679758at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013289">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O18221">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
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    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="506"/>
            <end position="568"/>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB16496.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y57G11A.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="O18221"/>
        </source>
    </evidence>
    <sequence length="598" mass="67280" checksum="69AED6ED9831082D" modified="2003-06-01" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2026-01-28" version="170" xmlns="https://uniprot.org/uniprot">
    <accession>O62348</accession>
    <name>O62348_CAEEL</name>
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        <recommendedName>
            <fullName evidence="11">AP-3 complex subunit beta</fullName>
        </recommendedName>
    </protein>
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        <name evidence="14 16" type="primary">apb-3</name>
        <name evidence="14" type="ORF">CELE_R11A5.1</name>
        <name evidence="16" type="ORF">R11A5.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB05601.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_492171.2">
        <property type="nucleotide sequence ID" value="NM_059770.6"/>
    </dbReference>
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    <dbReference type="PeptideAtlas" id="O62348"/>
    <dbReference type="GeneID" id="172553"/>
    <dbReference type="UCSC" id="R11A5.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000163"/>
    <dbReference type="CTD" id="172553"/>
    <dbReference type="WormBase" id="R11A5.1b">
        <property type="protein sequence ID" value="CE46936"/>
        <property type="gene ID" value="WBGene00000163"/>
        <property type="gene designation" value="apb-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_3_1_1"/>
    <dbReference type="OrthoDB" id="302453at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000163">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O62348">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
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    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="WormBase"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14796">
        <property type="entry name" value="AP3B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24080">
        <property type="entry name" value="AP3B1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01355">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP-3 complex subunit beta C-terminal" evidence="13">
        <location>
            <begin position="706"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="594"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="610"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAB05601.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="R11A5.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="O62348"/>
        </source>
    </evidence>
    <sequence length="935" mass="105530" checksum="4D6DCCFEB79AA688" modified="2012-03-21" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>O62358</accession>
    <name>O62358_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T02G6.5</name>
        <name evidence="2 4" type="ORF">T02G6.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB04673.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O62358"/>
    <dbReference type="UCSC" id="T02G6.5">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011388"/>
    <dbReference type="WormBase" id="T02G6.5a">
        <property type="protein sequence ID" value="CE42901"/>
        <property type="gene ID" value="WBGene00011388"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049370_1_0_1"/>
    <dbReference type="OrthoDB" id="5778587at2759"/>
    <dbReference type="PhylomeDB" id="O62358"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011388">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O62358">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012885">
        <property type="entry name" value="F-box_Sdz-33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21503:SF8">
        <property type="entry name" value="F-BOX ASSOCIATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21503">
        <property type="entry name" value="F-BOX-CONTAINING HYPOTHETICAL PROTEIN C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07735">
        <property type="entry name" value="FBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB04673.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T02G6.5a"/>
        </source>
    </evidence>
    <sequence length="387" mass="45822" checksum="217E84D4284DCEAE" modified="2008-09-23" version="3">MRLVLHHFIEVFLNDCLDEYLDILFRTLCHLQHKLWVKIFRLYKKPFNLHNLPYPAYRKIVLQMDICDMLQLSRTSSNTCLKTKKVNRKIYKLMISDPKLHDNNLITEDPLRQVYVIESKADLDFIYSSIKRVYGKNEGMFSSANFNYWIRTFCEHQKEQEKFRSIPYANSEELHHLLNFINQSVIVDELDLLIHHNSLFGDYKSILSHQMLDNCHDVEIFGPDFSLRNDEVNILLDRINLSGKLSIECMFSSSFNKEILFNIPQLEIWNALSFTLQDVMNMNCEVIILQHHILKSLDINRLIHYWLAGKMPNLRRIRVNANPDAKMLRGIVNYAWHPRRRPQVFRDGLEQLDCENGMDIVRSDGRIATLLDHNSFVDFLVWPHSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2025-10-08" version="177" xmlns="https://uniprot.org/uniprot">
    <accession>O62372</accession>
    <name>O62372_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">ddx-19</name>
        <name evidence="13" type="ORF">CELE_T07D4.4</name>
        <name evidence="15" type="ORF">T07D4.4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAA90407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T24662">
        <property type="entry name" value="T24662"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_495893.1">
        <property type="nucleotide sequence ID" value="NM_063492.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O62372"/>
    <dbReference type="SMR" id="O62372"/>
    <dbReference type="PeptideAtlas" id="O62372"/>
    <dbReference type="GeneID" id="174418"/>
    <dbReference type="UCSC" id="T07D4.4b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011580"/>
    <dbReference type="CTD" id="174418"/>
    <dbReference type="WormBase" id="T07D4.4c">
        <property type="protein sequence ID" value="CE18221"/>
        <property type="gene ID" value="WBGene00011580"/>
        <property type="gene designation" value="ddx-19"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011580">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O62372">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002543">
        <property type="entry name" value="DEAD boX helicase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="242"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="428"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAA90407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="T07D4.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="O62372"/>
        </source>
    </evidence>
    <sequence length="613" mass="67727" checksum="07A174B4CC54109E" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2025-10-08" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>O62376</accession>
    <name>O62376_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_T10C6.6</name>
        <name evidence="10 12" type="ORF">T10C6.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB07662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T24796">
        <property type="entry name" value="T24796"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_507025.1">
        <property type="nucleotide sequence ID" value="NM_074624.4"/>
    </dbReference>
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            <dbReference type="PeptideAtlas" id="O62376"/>
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<entry dataset="Swiss-Prot" created="2000-12-01" modified="2026-01-28" version="195" xmlns="https://uniprot.org/uniprot">
    <accession>O77469-2</accession>
    <name>FBLN1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Fibulin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fbl-1</name>
        <name type="synonym">fbln1</name>
        <name type="ORF">F56H11.1</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Matrix Biol." volume="17" first="635" last="646">
            <title>Identification of chicken and C. elegans fibulin-1 homologs and characterization of the C. elegans fibulin-1 gene.</title>
            <authorList>
                <person name="Barth J.L."/>
                <person name="Argraves K.M."/>
                <person name="Roark E.F."/>
                <person name="Little C.D."/>
                <person name="Argraves W.S."/>
            </authorList>
            <dbReference type="PubMed" id="9923656"/>
            <dbReference type="DOI" id="10.1016/S0945-053X(98)90114-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A AND B)</scope>
        <source>
            <strain>CB1489</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Curr. Biol." volume="14" first="2005" last="2010">
            <title>GON-1 and fibulin have antagonistic roles in control of organ shape.</title>
            <authorList>
                <person name="Hesselson D."/>
                <person name="Newman C."/>
                <person name="Kim K.W."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="15556862"/>
            <dbReference type="DOI" id="10.1016/j.cub.2004.11.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Curr. Biol." volume="14" first="2011" last="2018">
            <title>A fibulin-1 homolog interacts with an ADAM protease that controls cell migration in C. elegans.</title>
            <authorList>
                <person name="Kubota Y."/>
                <person name="Kuroki R."/>
                <person name="Nishiwaki K."/>
            </authorList>
            <dbReference type="PubMed" id="15556863"/>
            <dbReference type="DOI" id="10.1016/j.cub.2004.10.047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF GLY-288 AND HIS-290</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Development" volume="132" first="4223" last="4234">
            <title>Fibulin-1C and Fibulin-1D splice variants have distinct functions and assemble in a hemicentin-dependent manner.</title>
            <authorList>
                <person name="Muriel J.M."/>
                <person name="Dong C."/>
                <person name="Hutter H."/>
                <person name="Vogel B.E."/>
            </authorList>
            <dbReference type="PubMed" id="16120639"/>
            <dbReference type="DOI" id="10.1242/dev.02007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="J. Cell Biol." volume="175" first="217" last="223">
            <title>Growth control by EGF repeats of the C. elegans Fibulin-1C isoform.</title>
            <authorList>
                <person name="Hesselson D."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="17043142"/>
            <dbReference type="DOI" id="10.1083/jcb.200608061"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-624</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="20804" last="20809">
            <title>MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans.</title>
            <authorList>
                <person name="Kubota Y."/>
                <person name="Ohkura K."/>
                <person name="Tamai K.K."/>
                <person name="Nagata K."/>
                <person name="Nishiwaki K."/>
            </authorList>
            <dbReference type="PubMed" id="19104038"/>
            <dbReference type="DOI" id="10.1073/pnas.0804055106"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF GLY-288 AND HIS-290</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="Genetics" volume="190" first="1379" last="1388">
            <title>Tissue architecture in the Caenorhabditis elegans gonad depends on interactions among fibulin-1, type IV collagen and the ADAMTS extracellular protease.</title>
            <authorList>
                <person name="Kubota Y."/>
                <person name="Nagata K."/>
                <person name="Sugimoto A."/>
                <person name="Nishiwaki K."/>
            </authorList>
            <dbReference type="PubMed" id="22298704"/>
            <dbReference type="DOI" id="10.1534/genetics.111.133173"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 3 4 5">Involved in regulating the shape and adhesion of cells in the developing pharynx, intestine, body-wall muscle and gonadal tissue (PubMed:16120639). During gonadogenesis, regulates the width of gonads and the migration of distal tip cells (DTC) (PubMed:15556862, PubMed:17043142, PubMed:22298704). Together with type IV collagen let-2 and downstream of metalloprotease mig-17, recruits nidogen nid-1 to the gonad basement membrane thereby inducing basement membrane remodeling required for the directional migration of DTCs (PubMed:15556863, PubMed:19104038). Acts antagonistically with metalloprotease gon-1 to maintain optimal levels of type IV collagen emb-9 in the gonad basement membrane during gonadogenesis (PubMed:15556862, PubMed:17043142, PubMed:22298704). Required for larval development (PubMed:17043142).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 4">Secreted</location>
            <location evidence="1 2 4">Extracellular space</location>
            <location evidence="1 2 4">Extracellular matrix</location>
            <location evidence="1 2 4">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O77469-2</id>
            <name>a</name>
            <name>C</name>
            <name>Fibulin-1C</name>
            <sequence type="described" ref="VSP_001390 VSP_001388"/>
        </isoform>
        <isoform>
            <id>O77469-1</id>
            <name>c</name>
            <name>Fibulin-1D</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O77469-3</id>
            <name>b</name>
            <name>D</name>
            <sequence type="described" ref="VSP_001388"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001023236.1">
        <property type="nucleotide sequence ID" value="NM_001028065.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F56H11.1a">
        <property type="protein sequence ID" value="CE26701"/>
        <property type="gene ID" value="WBGene00001403"/>
        <property type="gene designation" value="fbl-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="15556862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15556863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16120639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17043142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="19104038"/>
        </source>
    </evidence>
    <sequence length="712" mass="77009" checksum="52CE8CF8BF296BC5" modified="2005-09-13" version="3" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2026-01-28" version="195" xmlns="https://uniprot.org/uniprot">
    <accession>O77469-3</accession>
    <name>FBLN1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Fibulin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fbl-1</name>
        <name type="synonym">fbln1</name>
        <name type="ORF">F56H11.1</name>
    </gene>
    <organism>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Matrix Biol." volume="17" first="635" last="646">
            <title>Identification of chicken and C. elegans fibulin-1 homologs and characterization of the C. elegans fibulin-1 gene.</title>
            <authorList>
                <person name="Barth J.L."/>
                <person name="Argraves K.M."/>
                <person name="Roark E.F."/>
                <person name="Little C.D."/>
                <person name="Argraves W.S."/>
            </authorList>
            <dbReference type="PubMed" id="9923656"/>
            <dbReference type="DOI" id="10.1016/S0945-053X(98)90114-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A AND B)</scope>
        <source>
            <strain>CB1489</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Curr. Biol." volume="14" first="2005" last="2010">
            <title>GON-1 and fibulin have antagonistic roles in control of organ shape.</title>
            <authorList>
                <person name="Hesselson D."/>
                <person name="Newman C."/>
                <person name="Kim K.W."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="15556862"/>
            <dbReference type="DOI" id="10.1016/j.cub.2004.11.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Curr. Biol." volume="14" first="2011" last="2018">
            <title>A fibulin-1 homolog interacts with an ADAM protease that controls cell migration in C. elegans.</title>
            <authorList>
                <person name="Kubota Y."/>
                <person name="Kuroki R."/>
                <person name="Nishiwaki K."/>
            </authorList>
            <dbReference type="PubMed" id="15556863"/>
            <dbReference type="DOI" id="10.1016/j.cub.2004.10.047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF GLY-288 AND HIS-290</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Development" volume="132" first="4223" last="4234">
            <title>Fibulin-1C and Fibulin-1D splice variants have distinct functions and assemble in a hemicentin-dependent manner.</title>
            <authorList>
                <person name="Muriel J.M."/>
                <person name="Dong C."/>
                <person name="Hutter H."/>
                <person name="Vogel B.E."/>
            </authorList>
            <dbReference type="PubMed" id="16120639"/>
            <dbReference type="DOI" id="10.1242/dev.02007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="J. Cell Biol." volume="175" first="217" last="223">
            <title>Growth control by EGF repeats of the C. elegans Fibulin-1C isoform.</title>
            <authorList>
                <person name="Hesselson D."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="17043142"/>
            <dbReference type="DOI" id="10.1083/jcb.200608061"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-624</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="20804" last="20809">
            <title>MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans.</title>
            <authorList>
                <person name="Kubota Y."/>
                <person name="Ohkura K."/>
                <person name="Tamai K.K."/>
                <person name="Nagata K."/>
                <person name="Nishiwaki K."/>
            </authorList>
            <dbReference type="PubMed" id="19104038"/>
            <dbReference type="DOI" id="10.1073/pnas.0804055106"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF GLY-288 AND HIS-290</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="Genetics" volume="190" first="1379" last="1388">
            <title>Tissue architecture in the Caenorhabditis elegans gonad depends on interactions among fibulin-1, type IV collagen and the ADAMTS extracellular protease.</title>
            <authorList>
                <person name="Kubota Y."/>
                <person name="Nagata K."/>
                <person name="Sugimoto A."/>
                <person name="Nishiwaki K."/>
            </authorList>
            <dbReference type="PubMed" id="22298704"/>
            <dbReference type="DOI" id="10.1534/genetics.111.133173"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O77469-3</id>
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            <name>D</name>
            <sequence type="described" ref="VSP_001388"/>
        </isoform>
        <isoform>
            <id>O77469-1</id>
            <name>c</name>
            <name>Fibulin-1D</name>
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        </isoform>
        <isoform>
            <id>O77469-2</id>
            <name>a</name>
            <name>C</name>
            <name>Fibulin-1C</name>
            <sequence type="described" ref="VSP_001388 VSP_001390"/>
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    </comment>
    <dbReference type="RefSeq" id="NP_001023237.1">
        <property type="nucleotide sequence ID" value="NM_001028066.6"/>
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        <property type="gene designation" value="fbl-1"/>
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        <property type="component" value="Chromosome IV"/>
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    <sequence length="689" mass="74625" checksum="0FED2023E11D6AFB" modified="2005-09-13" version="3" precursor="true"> </sequence>
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    <accession>P91862</accession>
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        <submittedName>
            <fullName evidence="8">Methyltransferase-like protein 17, mitochondrial</fullName>
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        <name evidence="8 10" type="primary">metl-17</name>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
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    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
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            <location evidence="1">Mitochondrion</location>
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        <property type="nucleotide sequence ID" value="NM_061191.4"/>
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    <dbReference type="AlphaFoldDB" id="P91862"/>
    <dbReference type="SMR" id="P91862"/>
    <dbReference type="STRING" id="6239.F32A7.4.1"/>
    <dbReference type="PaxDb" id="6239-F32A7.4"/>
    <dbReference type="PeptideAtlas" id="P91862"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
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    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB05500.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F32A7.4a"/>
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    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="P91862"/>
        </source>
    </evidence>
    <sequence length="529" mass="60304" checksum="871DD79B007DC28E" modified="1997-05-01" version="1"> </sequence>
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    <accession>Q09274-2</accession>
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        <recommendedName>
            <fullName>Isoform a of Degenerin-like protein unc-105</fullName>
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        <alternativeName>
            <fullName>Uncoordinated protein 105</fullName>
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        <name type="primary">unc-105</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1986" name="Genetics" volume="113" first="821" last="852">
            <title>Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Park E.-C."/>
                <person name="Horvitz R.H."/>
            </authorList>
            <dbReference type="PubMed" id="3744028"/>
        </citation>
        <scope>MUTAGENESIS OF PRO-134 AND GLU-677</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1986" name="Genetics" volume="113" first="853" last="867">
            <title>C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle.</title>
            <authorList>
                <person name="Park E.-C."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="3744029"/>
        </citation>
        <scope>MUTAGENESIS OF PRO-134 AND GLU-677</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1996" name="Science" volume="273" first="361" last="364">
            <title>Interaction between a putative mechanosensory membrane channel and a collagen.</title>
            <authorList>
                <person name="Liu J."/>
                <person name="Schrank B."/>
                <person name="Waterston R.H."/>
            </authorList>
            <dbReference type="PubMed" id="8662524"/>
            <dbReference type="DOI" id="10.1126/science.273.5273.361"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Neuron" volume="20" first="1231" last="1241">
            <title>The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations.</title>
            <authorList>
                <person name="Garcia-Anoveros J."/>
                <person name="Garcia J.A."/>
                <person name="Liu J.-D."/>
                <person name="Corey D.P."/>
            </authorList>
            <dbReference type="PubMed" id="9655510"/>
            <dbReference type="DOI" id="10.1016/S0896-6273(00)80503-6"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="J. Physiol. (Lond.)" volume="557" first="379" last="388">
            <title>Patch clamp study of the UNC-105 degenerin and its interaction with the LET-2 collagen in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Jospin M."/>
                <person name="Mariol M.-C."/>
                <person name="Segalat L."/>
                <person name="Allard B."/>
            </authorList>
            <dbReference type="PubMed" id="15020702"/>
            <dbReference type="DOI" id="10.1113/jphysiol.2003.057687"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="J. Physiol. (Lond.)" volume="559" first="715" last="720">
            <title>An amiloride-sensitive H+-gated Na+ channel in Caenorhabditis elegans body wall muscle cells.</title>
            <authorList>
                <person name="Jospin M."/>
                <person name="Allard B."/>
            </authorList>
            <dbReference type="PubMed" id="15254157"/>
            <dbReference type="DOI" id="10.1113/jphysiol.2004.069971"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-599</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09274-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_025926"/>
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        <isoform>
            <id>Q09274-1</id>
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            <sequence type="displayed"/>
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    <dbReference type="RefSeq" id="NP_495702.1">
        <property type="nucleotide sequence ID" value="NM_063301.6"/>
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    <dbReference type="WormBase" id="C41C4.5a">
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        <property type="gene designation" value="unc-105"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
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    <proteinExistence type="evidence at protein level"/>
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<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>Q09417-2</accession>
    <name>RIC1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform a of Guanine nucleotide exchange factor subunit R06F6.8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein RIC1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">R06F6.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09417-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_012311"/>
        </isoform>
        <isoform>
            <id>Q09417-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001369860.1">
        <property type="nucleotide sequence ID" value="NM_001383942.2"/>
    </dbReference>
    <dbReference type="WormBase" id="R06F6.8a">
        <property type="protein sequence ID" value="CE36946"/>
        <property type="gene ID" value="WBGene00011071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P40395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1468" mass="163047" checksum="072115E0B22E1801" modified="2004-12-21" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="189" xmlns="https://uniprot.org/uniprot">
    <accession>Q18518</accession>
    <name>Q18518_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ligand-Gated ion Channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">lgc-41</name>
        <name evidence="17" type="ORF">C39B10.2</name>
        <name evidence="15" type="ORF">CELE_C39B10.2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAA90332.4"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T19840">
        <property type="entry name" value="T19840"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359532.1">
        <property type="nucleotide sequence ID" value="NM_001373474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18518"/>
    <dbReference type="SMR" id="Q18518"/>
    <dbReference type="GeneID" id="183331"/>
    <dbReference type="UCSC" id="C39B10.2b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008022"/>
    <dbReference type="CTD" id="183331"/>
    <dbReference type="WormBase" id="C39B10.2a">
        <property type="protein sequence ID" value="CE53478"/>
        <property type="gene ID" value="WBGene00008022"/>
        <property type="gene designation" value="lgc-41"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010920_1_4_1"/>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008022">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18518">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000069">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000051">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022271640" evidence="11">
        <location>
            <begin position="26"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="39"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="249"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAA90332.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C39B10.2a"/>
        </source>
    </evidence>
    <sequence length="540" mass="61918" checksum="66CEEE7BE818C4EF" modified="2019-07-31" version="4"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-04" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2A948</accession>
    <name>Q2A948_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F40H3.1</name>
        <name evidence="2 4" type="ORF">F40H3.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD66151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040775.1">
        <property type="nucleotide sequence ID" value="NM_001047310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2A948"/>
    <dbReference type="SMR" id="Q2A948"/>
    <dbReference type="GeneID" id="185570"/>
    <dbReference type="UCSC" id="F40H3.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018249"/>
    <dbReference type="CTD" id="185570"/>
    <dbReference type="WormBase" id="F40H3.1b">
        <property type="protein sequence ID" value="CE39933"/>
        <property type="gene ID" value="WBGene00018249"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_550102_0_0_1"/>
    <dbReference type="OrthoDB" id="5866012at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018249">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2A948">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052664">
        <property type="entry name" value="BTB-MATH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743:SF170">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743">
        <property type="entry name" value="MEPRIN/TRAF-LIKE MATH FAMILY-C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD66151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F40H3.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q2A948"/>
        </source>
    </evidence>
    <sequence length="263" mass="30114" checksum="9344796604A45D75" modified="2006-04-04" version="1">MAAEVLQNEPHCFIAPSSSIDRPFKLLVQKETFLIDAESMSRISPIFNVMCFGKDFEKMDLSREIVDEKSNDIDCFLRAVHDTSMINSSNFALVLRLSNKYQVDPVIDACQNFIIRQHLDVLRADEILTMLIAAFEHHCKREVVQKLIKRLASEGNSVFTKLKISRYLPAQVYGSVISTSMNLNQAKEHELMNGHVLKMERSKIRWRQSVCEECKSVAECANCEECKKTVCRNHVSKLKCSSDYGAKLAADLKKKIVDFEWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-04" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2A949</accession>
    <name>Q2A949_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHD finger protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">phf-10</name>
        <name evidence="2" type="ORF">CELE_F33E11.6</name>
        <name evidence="4" type="ORF">F33E11.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD70455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041112.1">
        <property type="nucleotide sequence ID" value="NM_001047647.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2A949"/>
    <dbReference type="IntAct" id="Q2A949">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q2A949"/>
    <dbReference type="GeneID" id="3565141"/>
    <dbReference type="KEGG" id="cel:CELE_F33E11.6"/>
    <dbReference type="UCSC" id="F33E11.6b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018013"/>
    <dbReference type="CTD" id="3565141"/>
    <dbReference type="WormBase" id="F33E11.6a">
        <property type="protein sequence ID" value="CE39928"/>
        <property type="gene ID" value="WBGene00018013"/>
        <property type="gene designation" value="phf-10"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821917_0_0_1"/>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018013">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2A949">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd21085">
        <property type="entry name" value="WH_NTD_PHF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD70455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F33E11.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q2A949"/>
        </source>
    </evidence>
    <sequence length="338" mass="39656" checksum="76BDA2E475ABE9BB" modified="2006-04-04" version="1">MEDPVISEESNISSSETPATPTDSQEAASSQPAPISSRRETVNRNVYIMLDVNHRKVEPKDIIEYEWPVKSGDRWFLQEQIGELLDIKSFSRKYPDFTRRKVNHEEREFLEWNFNVHKLLNETLLRDMNAMRASEIHDMMQSDFGDIYMEYKKVVSQREREAQLEKAKEMEAIKNDSVKLAELRRKAVQNAVDFNKDIQNQRRNERKHFWDIQTNIIQSRRNSWKVMKPEATRPGPYPVALIPGQYQHYFKKFSSEELNRLPLGTVIESSHLYPAVREPSPPPLNIAEQDLVRFEREEAMRAREATLNTTPQSSMAQIKQGRKLIAAYDSDDEENHIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2EEN1</accession>
    <name>Q2EEN1_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">RSD-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rsd-2</name>
        <name evidence="4" type="ORF">CELE_F52G2.2</name>
        <name evidence="6" type="ORF">F52G2.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040953.1">
        <property type="nucleotide sequence ID" value="NM_001047488.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2EEN1"/>
    <dbReference type="SMR" id="Q2EEN1"/>
    <dbReference type="PeptideAtlas" id="Q2EEN1"/>
    <dbReference type="GeneID" id="178322"/>
    <dbReference type="UCSC" id="F52G2.2b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004681"/>
    <dbReference type="CTD" id="178322"/>
    <dbReference type="WormBase" id="F52G2.2b">
        <property type="protein sequence ID" value="CE39737"/>
        <property type="gene ID" value="WBGene00004681"/>
        <property type="gene designation" value="rsd-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006438_0_0_1"/>
    <dbReference type="OrthoDB" id="5879648at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004681">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2EEN1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040930">
        <property type="entry name" value="AF-9_AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011508">
        <property type="entry name" value="RSD-2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17793">
        <property type="entry name" value="AHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07547">
        <property type="entry name" value="RSD-2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSD-2 N-terminal" evidence="2">
        <location>
            <begin position="91"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RSD-2 N-terminal" evidence="2">
        <location>
            <begin position="363"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="AF-9 ANC1 homology" evidence="3">
        <location>
            <begin position="771"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ76945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F52G2.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q2EEN1"/>
        </source>
    </evidence>
    <sequence length="1129" mass="126684" checksum="24C4F9A410211261" modified="2006-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q2EEN3</accession>
    <name>Q2EEN3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Equilibrative nucleoside transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ent-4</name>
        <name evidence="10" type="synonym">ent-6</name>
        <name evidence="10" type="ORF">C47A4.2</name>
        <name evidence="8" type="ORF">CELE_C47A4.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040927.1">
        <property type="nucleotide sequence ID" value="NM_001047462.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2EEN3"/>
    <dbReference type="SMR" id="Q2EEN3"/>
    <dbReference type="GeneID" id="178339"/>
    <dbReference type="UCSC" id="C47A4.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008123"/>
    <dbReference type="CTD" id="178339"/>
    <dbReference type="WormBase" id="C47A4.2c">
        <property type="protein sequence ID" value="CE39699"/>
        <property type="gene ID" value="WBGene00008123"/>
        <property type="gene designation" value="ent-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021611_0_1_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008123">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2EEN3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF36">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ76936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="C47A4.2c"/>
        </source>
    </evidence>
    <sequence length="383" mass="42798" checksum="88468396B3FD6EF4" modified="2006-03-21" version="1">MFITIAPQYYVDYWFTVNGTATHYADSFQSAMGVVAQVPNLIVAIINVLNLIRGPLLYRVLAPLAFNSLLIVIILALVIFQQPSDQARNWFYIVSLIIVMAMNASNGLYQNSFFGMAADFPAKYSNAVVIGTNICGTFTSVLAIVATLAFSTQAETVALIYFGISLLILFVCLVSWWFCKKMDFYKYYVSKGNRLRAAQEQSSFDYRPYLETIKYCWLQCICVFLVYFVSLSVFPTVLAGFQPGYTVFPNDVYAGIAVFLNFNFFAAVGNVAATFVTFPGPRLLIVPCVIRLLFIPFFMFSNYLPHSRTMGVLFTNEWIFFFGNTLLAFTSGYFSSLGMMYTPRVCPPEYSKLAGQVSALSLVLGITAGVSFTYAITAMVNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q2EEN4</accession>
    <name>Q2EEN4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srz-38</name>
        <name evidence="4" type="ORF">C35D6.9</name>
        <name evidence="2" type="ORF">CELE_C35D6.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040922.1">
        <property type="nucleotide sequence ID" value="NM_001047457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2EEN4"/>
    <dbReference type="GeneID" id="3565113"/>
    <dbReference type="UCSC" id="C35D6.9a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00023508"/>
    <dbReference type="CTD" id="3565113"/>
    <dbReference type="WormBase" id="C35D6.9b">
        <property type="protein sequence ID" value="CE39686"/>
        <property type="gene ID" value="WBGene00023508"/>
        <property type="gene designation" value="srz-38"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056063_2_1_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018817">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31720">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS Z-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31720:SF3">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS Z-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10325">
        <property type="entry name" value="7TM_GPCR_Srz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ76925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C35D6.9b"/>
        </source>
    </evidence>
    <sequence length="111" mass="13039" checksum="25EE1B24439B2E56" modified="2006-03-21" version="1">MYFSVRKLSNLVSVKRSTPQRFILWQAITVLIFKFMFIVLVLTCLWGSLDVMIMLVSTTGLDIFSTPLIVELSYIGCNKRNMKTLFTGFSFRKFIRVLFDIEENVHVEQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q2EEN9</accession>
    <name>Q2EEN9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_K08E7.8</name>
        <name evidence="3 5" type="ORF">K08E7.8</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040970.1">
        <property type="nucleotide sequence ID" value="NM_001047505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2EEN9"/>
    <dbReference type="SMR" id="Q2EEN9"/>
    <dbReference type="GeneID" id="178213"/>
    <dbReference type="UCSC" id="K08E7.8a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010675"/>
    <dbReference type="CTD" id="178213"/>
    <dbReference type="WormBase" id="K08E7.8b">
        <property type="protein sequence ID" value="CE39748"/>
        <property type="gene ID" value="WBGene00010675"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070683_0_1_1"/>
    <dbReference type="OrthoDB" id="1060944at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010675">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2EEN9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ76930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K08E7.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q2EEN9"/>
        </source>
    </evidence>
    <sequence length="142" mass="16041" checksum="9532B8C0EE21593A" modified="2006-03-21" version="1">MYMADAVYMLIKGYEITKVSIQDNGFKKFPKKFVIKFPTATILNMANNEISEIPEEVATWTSLKGLNAAKNKISKFPEPFLQLKNLIYLDLNGNQLEEIDVDLFYSSLPALIKLNLSGNEGLGDETKKKLKALKPEKLDLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-11-23" modified="2026-01-28" version="166" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ZR39</accession>
    <name>Q5ZR39_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Papilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">mec-1</name>
        <name evidence="12" type="ORF">CELE_T07H8.4</name>
        <name evidence="14" type="ORF">T07H8.4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD66555.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024117.2">
        <property type="nucleotide sequence ID" value="NM_001028946.6"/>
    </dbReference>
    <dbReference type="SMR" id="Q5ZR39"/>
    <dbReference type="GeneID" id="188259"/>
    <dbReference type="KEGG" id="cel:CELE_T07H8.4"/>
    <dbReference type="UCSC" id="T07H8.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003165"/>
    <dbReference type="CTD" id="188259"/>
    <dbReference type="WormBase" id="T07H8.4d">
        <property type="protein sequence ID" value="CE47967"/>
        <property type="gene ID" value="WBGene00003165"/>
        <property type="gene designation" value="mec-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003165">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q5ZR39">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043062">
        <property type="term" value="P:extracellular structure organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007638">
        <property type="term" value="P:mechanosensory behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009612">
        <property type="term" value="P:response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd21630">
        <property type="entry name" value="Kunitz_TAP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000820">
        <property type="entry name" value="CBN-MEC-1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000028">
        <property type="entry name" value="CBN-MEC-1 protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000042">
        <property type="entry name" value="CBN-MEC-1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000024">
        <property type="entry name" value="Protein CBR-MEC-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000026">
        <property type="entry name" value="Serine protease inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000027">
        <property type="entry name" value="Si:dkeyp-73b11.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF217">
        <property type="entry name" value="BOOPHILIN-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="11">
        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="190"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="11">
        <location>
            <begin position="234"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="11">
        <location>
            <begin position="399"/>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q5ZR40"/>
        </source>
    </evidence>
    <sequence length="2006" mass="228288" checksum="2EEEF789BDDF063C" modified="2013-02-06" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-11-23" modified="2026-01-28" version="167" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ZR41</accession>
    <name>Q5ZR41_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CRE-MEC-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">mec-1</name>
        <name evidence="9" type="ORF">CELE_T07H8.4</name>
        <name evidence="11" type="ORF">T07H8.4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD66553.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367615.1">
        <property type="nucleotide sequence ID" value="NM_001380681.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5ZR41"/>
    <dbReference type="GeneID" id="188259"/>
    <dbReference type="UCSC" id="T07H8.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003165"/>
    <dbReference type="CTD" id="188259"/>
    <dbReference type="WormBase" id="T07H8.4b">
        <property type="protein sequence ID" value="CE47875"/>
        <property type="gene ID" value="WBGene00003165"/>
        <property type="gene designation" value="mec-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003165">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q5ZR41">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043062">
        <property type="term" value="P:extracellular structure organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007638">
        <property type="term" value="P:mechanosensory behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009612">
        <property type="term" value="P:response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd21630">
        <property type="entry name" value="Kunitz_TAP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000820">
        <property type="entry name" value="CBN-MEC-1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000028">
        <property type="entry name" value="CBN-MEC-1 protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000042">
        <property type="entry name" value="CBN-MEC-1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000024">
        <property type="entry name" value="Protein CBR-MEC-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000027">
        <property type="entry name" value="Si:dkeyp-73b11.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF375">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="242"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="407"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="611"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="855"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1100"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1250"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1319"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1386"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1454"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1530"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1593"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="683"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="781"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1163"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="783"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1190"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD66553.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="T07H8.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="Q5ZR41"/>
        </source>
    </evidence>
    <sequence length="1685" mass="191861" checksum="D23181187B211D91" modified="2013-02-06" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ZR76-2</accession>
    <name>GDPP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of GDP-D-glucose phosphorylase 1</fullName>
            <ecNumber evidence="2">2.7.7.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Metabolite control phosphorylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mcp-1</name>
        <name evidence="4" type="ORF">C10F3.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="21511" last="21523">
            <title>A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.</title>
            <authorList>
                <person name="Adler L.N."/>
                <person name="Gomez T.A."/>
                <person name="Clarke S.G."/>
                <person name="Linster C.L."/>
            </authorList>
            <dbReference type="PubMed" id="21507950"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.238774"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2020" name="J. Cell Biol." volume="219" first="0" last="0">
            <title>The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.</title>
            <authorList>
                <person name="Schulz A."/>
                <person name="Sekine Y."/>
                <person name="Oyeyemi M.J."/>
                <person name="Abrams A.J."/>
                <person name="Basavaraju M."/>
                <person name="Han S.M."/>
                <person name="Groth M."/>
                <person name="Morrison H."/>
                <person name="Strittmatter S.M."/>
                <person name="Hammarlund M."/>
            </authorList>
            <dbReference type="PubMed" id="31968056"/>
            <dbReference type="DOI" id="10.1083/jcb.201807127"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q5ZR76-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_041658"/>
        </isoform>
        <isoform>
            <id>Q5ZR76-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.7.78" evidence="2"/>
    <dbReference type="RefSeq" id="NP_001379651.1">
        <property type="nucleotide sequence ID" value="NM_001392523.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C10F3.4b">
        <property type="protein sequence ID" value="CE37609"/>
        <property type="gene ID" value="WBGene00015678"/>
        <property type="gene designation" value="mcp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q6ZNW5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="21507950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C10F3.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C10F3.4b"/>
        </source>
    </evidence>
    <sequence length="458" mass="52682" checksum="039455D4AB5B3D6F" modified="2004-11-23" version="1">MPMRKIVMLGANARTQRSVSSIQLPAEYSPSASSAPYFNYSPDDFILDLRSHQSDEIYENGNSNHEKDEKKALKELLHERWENAKQYNAFNYPLNCMYRCLDGKYDLSMQLNIERGELRRKPMHFKNIKEPFNHLRFNFAKLHDHEILFYLKCDTDPISNDLLDRHLVAVNASPLERDHSLIVPSVNKCSPQVLTLQAVRIAVDLMLLVDDDMFHILFNSLLGQASVNHLHLHAMYWPYDSDLINRKCEPLHDVPNVYVIRPPVWICPAIVFQLDSLDNYEQFKMNIYKCVEHLTESNQAHNLFLARAQPIRTTGAEKEEDRRGERPQLVTCYVFPRMNMIGAKPPSNFNPAANELAGNLTSYTIRFFESANEQSVIRIIEEEASLDDDTFRSLCFDLADVLIGRSVGTSRPQDLDTLAGLTSPEIDELRDSFQSFMPRSPSIRHRSSTRAQSDEGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q86FS9</accession>
    <name>Q86FS9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyltransferase</fullName>
            <ecNumber evidence="14">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CELE_K07B1.4</name>
        <name evidence="15 17" type="ORF">K07B1.4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="14"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD68615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T15251">
        <property type="entry name" value="T15251"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_872180.1">
        <property type="nucleotide sequence ID" value="NM_182380.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86FS9"/>
    <dbReference type="GeneID" id="179314"/>
    <dbReference type="UCSC" id="K07B1.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019464"/>
    <dbReference type="CTD" id="179314"/>
    <dbReference type="WormBase" id="K07B1.4b">
        <property type="protein sequence ID" value="CE11882"/>
        <property type="gene ID" value="WBGene00019464"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023995_0_1_1"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019464">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86FS9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD68615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="K07B1.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="Q86FS9"/>
        </source>
    </evidence>
    <sequence length="339" mass="39020" checksum="87DFAC2DE3CDA7BF" modified="2003-06-01" version="1">MPHLLGVEWAPLNIPLARRLQTLGALHFFFITLFTPVLVLTVPFYMLYTVLWPLIFLYGLWMIYDWNSPKKGAYMSNWFQRQRIHSWYANYFPVKLHTTSDMPEEHNYLIGYHPHGIISMAAFINFATNGTGILDTLPRIRFHLCTLVGQFWTPWRREWGLLHGMIDCSRESIKHVLEHEKKGKAVVLVVGGAEEALDAHPGCHILTLKKRKGFVKIALQTGAQLVPCYSFGENDIFNQAENPKGSTIRQFQTIMKRVLGFSPPAFYGRGVFNYTFGLLPFRKPINTVLGAPISVTKTVNPTQEQIDTLHQTYMDRLHELFEEHKTKYDVSPTTQLVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2025-10-08" version="186" xmlns="https://uniprot.org/uniprot">
    <accession>Q86G45</accession>
    <accession>Q8MPY6</accession>
    <name>Q86G45_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Voltage-dependent calcium channel type A subunit alpha-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 26" type="primary">unc-2</name>
        <name evidence="24" type="ORF">CELE_T02C5.5</name>
        <name evidence="26" type="ORF">T02C5.5</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2003" name="J. Neurosci." volume="23" first="6537" last="6545">
            <title>Critical residues of the Caenorhabditis elegans unc-2 voltage-gated calcium channel that affect behavioral and physiological properties.</title>
            <authorList>
                <person name="Mathews E.A."/>
                <person name="Garcia E."/>
                <person name="Santi C.M."/>
                <person name="Mullen G.P."/>
                <person name="Thacker C."/>
                <person name="Moerman D.G."/>
                <person name="Snutch T.P."/>
            </authorList>
            <dbReference type="PubMed" id="12878695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Mathews E."/>
                <person name="Thacker C."/>
                <person name="Snutch T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="4">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="AY264781">
        <property type="protein sequence ID" value="AAP13107.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD74385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741732.2">
        <property type="nucleotide sequence ID" value="NM_171638.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q86G45"/>
    <dbReference type="GeneID" id="180570"/>
    <dbReference type="UCSC" id="T02C5.5d.3">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006742"/>
    <dbReference type="CTD" id="180570"/>
    <dbReference type="WormBase" id="T02C5.5b">
        <property type="protein sequence ID" value="CE34980"/>
        <property type="gene ID" value="WBGene00006742"/>
        <property type="gene designation" value="unc-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000540_3_0_1"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006742">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86G45">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035545">
        <property type="term" value="P:determination of left/right asymmetry in nervous system"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042045">
        <property type="term" value="P:epithelial fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000043">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000059">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000068">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000011">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000013">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
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            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R05D8.2a"/>
        </source>
    </evidence>
    <sequence length="333" mass="37843" checksum="A6BE772ECE54F815" modified="2012-01-25" version="2">MFINWAHFIIPKITFILSFIANPVFVYLIRTEKVIQFGDYRYLLYFFAIFNLTASVVDILIPACVYSYRYAAVFFIVDSVFSERSNFAPTLISLRCAFIAGTYGILNIHFIFRYNVLKNTSFVSHYFMPYGLILSIFLVIFHIGLWTFVVEPTMYSSDESRNYVRQAFQEEYGVDVNTISTKIAVYAEASSGIVFRAWIGTGVVTVIASYSMTLYFVLGYKIMSGLNQGSATMSLKTAQMQKRLFWALTIQTIIPICVSFMPVTLVLYGSAFCIDFPNWINWGSATAISFFPFLDPLAIIMCLPALRQRLGRKIGIRPSQVQVSSNQINTIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N5M1</accession>
    <name>Q9N5M1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CELE_H20J04.4</name>
        <name evidence="12 14" type="ORF">H20J04.4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040788.1">
        <property type="nucleotide sequence ID" value="NM_001047323.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N5M1"/>
    <dbReference type="SMR" id="Q9N5M1"/>
    <dbReference type="GeneID" id="186756"/>
    <dbReference type="KEGG" id="cel:CELE_H20J04.4"/>
    <dbReference type="UCSC" id="H20J04.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019219"/>
    <dbReference type="CTD" id="186756"/>
    <dbReference type="WormBase" id="H20J04.4a">
        <property type="protein sequence ID" value="CE32054"/>
        <property type="gene ID" value="WBGene00019219"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019219">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N5M1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="120"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="319"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD61679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="H20J04.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N5M1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54884" checksum="3CFC6F91D3640B04" modified="2003-03-01" version="2">MSKVCDAILSDDDDDLEMDEEQEKPSTSSKSVKNEEFEEFEDGEDVEDEEDEASDEDEEESEGEEGDEFKSSDDTPKPIQISEDNMTTKKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDTIAKVFKKIQFFVLDEADRMLEGQYNDQLKPIFESISEKRQTLLLSATITNNINMLHRVSTRKPYFFEDKGKDDESTVDRLEQKYVVCPVAVKDAYLVYVVKNYSEKNPKSSVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSFVTQYDVELLQAVEQVIGKKLDELKVKIQTFRKNIWKTQKSTRIFNFCF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-10-25" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q9U2H9-2</accession>
    <name>EF1B2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Probable elongation factor 1-beta/1-delta 2</fullName>
            <shortName>EF-1-beta/delta 2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eef-1B.2</name>
        <name evidence="2" type="ORF">Y41E3.10</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2006-04" db="UniProtKB">
            <authorList>
                <person name="Bienvenut W.V."/>
            </authorList>
        </citation>
        <scope>PROTEIN SEQUENCE OF 2-11; 177-197; 201-222 AND 235-243</scope>
        <scope>ACETYLATION AT SER-2</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9U2H9-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9U2H9-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_047489"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001122811.1">
        <property type="nucleotide sequence ID" value="NM_001129339.2"/>
    </dbReference>
    <dbReference type="WormBase" id="Y41E3.10b">
        <property type="protein sequence ID" value="CE40788"/>
        <property type="gene ID" value="WBGene00012768"/>
        <property type="gene designation" value="eef-1B.2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="EMBL" id="CAB63360.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="Y41E3.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y41E3.10b"/>
        </source>
    </evidence>
    <sequence length="440" mass="49006" checksum="9F4D92CFC425E264" modified="2007-01-23" version="4">MSVEGLLSEVKHFNAHHLDAALGEQLFYGGKRVFSDVKPGTSSGGDHGCKGGKSELKGAIHNAKHAADKALNKEGGEDVSKLREEHSALAKKVDDLASLVAELQLQLSTLRQGQVNHRRHVLILGDGNLSFSLAIASSDPETVYFATVFDSKEQFLKKYNAHDTLNALDALSNVILCFGVDATDLPVRWSNIFNTVIMNFPHPGGKTNLRKSKILLSGIFASLRSIMDSQAVFLLSLAIGQSGLEKVSDPWMNELPSHKKDSWQAIYLGAENGFILDSLERFDTDRFASYRSSGYKETKKGFNNREGLTFSFKKCDNQQKSLRDFQLAEPPRSGKFKFNYYRPFYAQDLSILFKIGESEGEKLAVELVKSIAGNCLAAISEIEYLRSICPDPPLPNRIYRIIWHGLELPMGREMCSRIHEELRNRIAEEIVANNLPLVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBT4</accession>
    <name>U4PBT4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">cec-2</name>
        <name evidence="4" type="ORF">C50A2.2</name>
        <name evidence="2" type="ORF">CELE_C50A2.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294532.1">
        <property type="nucleotide sequence ID" value="NM_001307603.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBT4"/>
    <dbReference type="GeneID" id="176934"/>
    <dbReference type="AGR" id="WB:WBGene00016796"/>
    <dbReference type="CTD" id="176934"/>
    <dbReference type="WormBase" id="C50A2.2c">
        <property type="protein sequence ID" value="CE48688"/>
        <property type="gene ID" value="WBGene00016796"/>
        <property type="gene designation" value="cec-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_601626_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016796">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBT4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C50A2.2c"/>
        </source>
    </evidence>
    <sequence length="455" mass="52158" checksum="3DA870600668DB8C" modified="2013-12-11" version="1">MKDDDRSWNVSRNSNRSRNRSKSSSKPAQRTEPMTQREKFDAILQISEISLEKQYKLTNKKVPRRSQFTDPDAPKKKSKGARHYRDQNLKTLFKSSLIRKYRKPQESDDDLEPDVAQDSPENTPAPPTKSPESSGFSENLENLGANTPSPSPDFEEEHLEKKPETGNLTENRPKRVYSHETAESMENYAKLLLYTAFDTKSWETLGGHIKNGFRLSFVCSNGLTIIENVVELNKNLNKFSDSRESRMVADLFELLLKKGVEFDEKTLPPTMCAAVRSTRYDIRRDFRCLHNQYIDKRPRMCEWFSATGGGGSCGTTEICTFWNNDAGYLPNTHQRSKFHVDLSEFTGNNLGLLAFSMAWHEDFIDNNSGGPEIVKNNRFNAHIDVPCFTLWMNGKMCEKLENSHGLSIFRPLGTVLDVNELKIKITEHSSRFVAILPVFNLNSDWKNCFFPLENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBU4</accession>
    <name>U4PBU4_CAEEL</name>
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        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_Y41D4A.4</name>
        <name evidence="8 10" type="ORF">Y41D4A.4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBU4"/>
    <dbReference type="SMR" id="U4PBU4"/>
    <dbReference type="AGR" id="WB:WBGene00021506"/>
    <dbReference type="WormBase" id="Y41D4A.4b">
        <property type="protein sequence ID" value="CE48539"/>
        <property type="gene ID" value="WBGene00021506"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021506">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBU4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007365984" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="18"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDH93340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y41D4A.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBU4"/>
        </source>
    </evidence>
    <sequence length="583" mass="67048" checksum="56A7BB0EFEB09D51" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBU8</accession>
    <name>U4PBU8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">plst-1</name>
        <name evidence="6" type="ORF">CELE_Y104H12BR.1</name>
        <name evidence="8" type="ORF">Y104H12BR.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294438.1">
        <property type="nucleotide sequence ID" value="NM_001307509.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBU8"/>
    <dbReference type="SMR" id="U4PBU8"/>
    <dbReference type="PeptideAtlas" id="U4PBU8"/>
    <dbReference type="GeneID" id="3564941"/>
    <dbReference type="KEGG" id="cel:CELE_Y104H12BR.1"/>
    <dbReference type="AGR" id="WB:WBGene00022425"/>
    <dbReference type="CTD" id="3564941"/>
    <dbReference type="WormBase" id="Y104H12BR.1a">
        <property type="protein sequence ID" value="CE49057"/>
        <property type="gene ID" value="WBGene00022425"/>
        <property type="gene designation" value="plst-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015284_0_1_1"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022425">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBU8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21298">
        <property type="entry name" value="CH_PLS_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21301">
        <property type="entry name" value="CH_PLS_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000066">
        <property type="entry name" value="plastin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="117"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="239"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH93209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y104H12BR.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBU8"/>
        </source>
    </evidence>
    <sequence length="367" mass="40945" checksum="835E714571F9030C" modified="2013-12-11" version="1">MRWVNYHLERAGTQRRLHNFTSDIVDSEIYTHLLHQIAPNGSGVTLSPLGVHGNVPRAGAMLDEAEKLDCREFVTATDVAAGNYKLNLAFVANLFNKHPNLPDPGADEVVEDVIEETREEKTYRNWMNSMGVDPYVNWLYADLQNGVVIFQLYDIIRPGMVTWKRVVRTFHKLRGMMDQIQNCNYAVELGKQLRFSLVGIQGKDIYDGNQTLTLALVWQLMRAYTLSVLAQCTQSGDSLPADKDIVAWVNEKLKNSGKSTSIRSFQDPAISDGKVVLDLIDAIKPNVIDHSLVKSGKSNEDKMSNAKYAITCGRKIGAKIYALPEDIVEVKPKMVLTVFACLMARDYLPDMKQGAASAPIVPMINGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBV0</accession>
    <name>U4PBV0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y41D4A.6</name>
        <name evidence="2 4" type="ORF">Y41D4A.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBV0"/>
    <dbReference type="SMR" id="U4PBV0"/>
    <dbReference type="PeptideAtlas" id="U4PBV0"/>
    <dbReference type="AGR" id="WB:WBGene00021508"/>
    <dbReference type="WormBase" id="Y41D4A.6c">
        <property type="protein sequence ID" value="CE21835"/>
        <property type="gene ID" value="WBGene00021508"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_1"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021508">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBV0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y41D4A.6c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBV0"/>
        </source>
    </evidence>
    <sequence length="139" mass="15751" checksum="7FAF1E1EEFDAB7ED" modified="2013-12-11" version="1">MYASSRSEALNTIVRRRIFAGNYFLMKQYRQKYFERALKVRRIIHDELRQAFREVDLIVTPTASGTAPKYSELRDTLFSKEDNDDYFTQAANLAGIPSISVPVGVAEDGLPIGVQLMADKLQDRAVCDVAHILDGLIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBV2</accession>
    <name>U4PBV2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide Sugar TransPorter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">nstp-6</name>
        <name evidence="9" type="ORF">B0212.4</name>
        <name evidence="7" type="ORF">CELE_B0212.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380143.1">
        <property type="nucleotide sequence ID" value="NM_001392282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBV2"/>
    <dbReference type="SMR" id="U4PBV2"/>
    <dbReference type="GeneID" id="177116"/>
    <dbReference type="AGR" id="WB:WBGene00015038"/>
    <dbReference type="CTD" id="177116"/>
    <dbReference type="WormBase" id="B0212.4d">
        <property type="protein sequence ID" value="CE48680"/>
        <property type="gene ID" value="WBGene00015038"/>
        <property type="gene designation" value="nstp-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024645_1_0_1"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015038">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBV2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDH93214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="B0212.4d"/>
        </source>
    </evidence>
    <sequence length="127" mass="14111" checksum="2191785B05CB9736" modified="2013-12-11" version="1">MFEGWSNMVWLVTILNSVGGLCISLVMKYADNVMKTYCQSIAIGLTSLVSICLGERILTVYLVYGVTLVTSSVVVYSLFPVAPPALSDYHKLEQQDDVAELLKSSGVEDEEEEEDEIFGELEHKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBV4</accession>
    <name>U4PBV4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BUB1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y41D4A.7</name>
        <name evidence="3 5" type="ORF">Y41D4A.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294551.1">
        <property type="nucleotide sequence ID" value="NM_001307622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBV4"/>
    <dbReference type="GeneID" id="189816"/>
    <dbReference type="AGR" id="WB:WBGene00021509"/>
    <dbReference type="CTD" id="189816"/>
    <dbReference type="WormBase" id="Y41D4A.7b">
        <property type="protein sequence ID" value="CE48882"/>
        <property type="gene ID" value="WBGene00021509"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_742338_0_0_1"/>
    <dbReference type="OrthoDB" id="5840149at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021509">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBV4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056660">
        <property type="entry name" value="DUF7758"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38624:SF2">
        <property type="entry name" value="BUB1 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38624">
        <property type="entry name" value="PROTEIN CBG08397-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24944">
        <property type="entry name" value="DUF7758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7758" evidence="2">
        <location>
            <begin position="74"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y41D4A.7b"/>
        </source>
    </evidence>
    <sequence length="358" mass="42060" checksum="7BCC46AB5D20D694" modified="2013-12-11" version="1">MNPKPGFLRRQWRKVKGEVSNALLSQYRRCVIQMKRCLRENTDVDQQRRKSQAKLHPLPDRPLRRVASKLNRKPTNEIARLRKKGDDWNANDLFKFQYSDPEEGTPEERKQLCYDWLDRLHEISKKYCYLAWYESAIYACYYRLAPILVDPVEKKRIWHDVKHEYAEIFMMGRRIWRRAIHPSRLRVFYDLAMLCVRFGDMENDDTVPKFKELMSDSTNFDFKVLNETEFIKSLDKVIKLENIVIDQFYKRRRSSGSIRSSFRSRRNTDCSPSRRSEQDSTPIPPAKPEDQDDACSLAESLQQMSISLPAVPDADFPPQPKISTSLTIPTIVVDGPDTTSSTSRTSRPNSPRLVRFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBW0</accession>
    <name>U4PBW0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">plx-1</name>
        <name evidence="15" type="ORF">CELE_Y55F3AL.1</name>
        <name evidence="17" type="ORF">Y55F3AL.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294556.1">
        <property type="nucleotide sequence ID" value="NM_001307627.3"/>
    </dbReference>
    <dbReference type="SMR" id="U4PBW0"/>
    <dbReference type="PeptideAtlas" id="U4PBW0"/>
    <dbReference type="GeneID" id="246019"/>
    <dbReference type="AGR" id="WB:WBGene00004047"/>
    <dbReference type="CTD" id="246019"/>
    <dbReference type="WormBase" id="Y55F3AL.1d">
        <property type="protein sequence ID" value="CE49043"/>
        <property type="gene ID" value="WBGene00004047"/>
        <property type="gene designation" value="plx-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001436_2_0_1"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004047">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBW0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01180">
        <property type="entry name" value="IPT_plexin_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12790">
        <property type="entry name" value="RasGAP_plexin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11236">
        <property type="entry name" value="Sema_plexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000033">
        <property type="entry name" value="PLeXin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000036">
        <property type="entry name" value="PLeXin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002538">
        <property type="entry name" value="PLeXin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000421">
        <property type="entry name" value="Plexin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
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            <begin position="1069"/>
            <end position="1091"/>
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        <location>
            <begin position="1"/>
            <end position="305"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDH93355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="Y55F3AL.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBW0"/>
        </source>
    </evidence>
    <sequence length="1756" mass="196192" checksum="C3BA0294741F49AC" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBW3</accession>
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        <submittedName>
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        <name evidence="9 11" type="primary">fmil-1</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditina</taxon>
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            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
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    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
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    <dbReference type="EMBL" id="BX284604">
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    <dbReference type="KEGG" id="cel:CELE_Y37E11AL.6"/>
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    <dbReference type="CTD" id="189621"/>
    <dbReference type="WormBase" id="Y37E11AL.6a">
        <property type="protein sequence ID" value="CE48732"/>
        <property type="gene ID" value="WBGene00021362"/>
        <property type="gene designation" value="fmil-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5795156at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021362">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBW3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cadherin-like_sf"/>
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        <property type="entry name" value="GAIN_B"/>
    </dbReference>
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        <property type="entry name" value="GAIN_dom_sf"/>
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        <property type="entry name" value="GPS"/>
    </dbReference>
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        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
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    </feature>
    <feature type="chain" id="PRO_5004652791" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="682"/>
            <end position="702"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="714"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="905"/>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDH93224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y37E11AL.6a"/>
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    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBW3"/>
        </source>
    </evidence>
    <sequence length="1029" mass="116890" checksum="167FBC397502B2F6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBW7</accession>
    <name>U4PBW7_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">Hikeshi-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_F42A6.6</name>
        <name evidence="4 6" type="ORF">F42A6.6</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294457.1">
        <property type="nucleotide sequence ID" value="NM_001307528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBW7"/>
    <dbReference type="SMR" id="U4PBW7"/>
    <dbReference type="GeneID" id="185650"/>
    <dbReference type="AGR" id="WB:WBGene00018328"/>
    <dbReference type="CTD" id="185650"/>
    <dbReference type="WormBase" id="F42A6.6d">
        <property type="protein sequence ID" value="CE48654"/>
        <property type="gene ID" value="WBGene00018328"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018328">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBW7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="140"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDH93229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F42A6.6d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBW7"/>
        </source>
    </evidence>
    <sequence length="203" mass="22368" checksum="0909F4ACAE07E264" modified="2013-12-11" version="1">MSGIFGVIVSGRTPIEVVPVSDTEFTCEIVNADAINHVVVFLTGAQPFPDGIGGSVYIRWPTQDGGNWHYLGFICNEKPSAIYKVAQLHKSDASHSFSQFDNQMQLYSSGSAQIGINAESLSDITGRQAADGTQASQQSTLVEFAEKMIRNLINHTESFSVRLPNPSGGSLEYIPVSAFQSWYNSFSRRFQANPYFWRSLNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBX0</accession>
    <name>U4PBX0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">madf-1</name>
        <name evidence="3" type="ORF">CELE_Y55F3BR.5</name>
        <name evidence="5" type="ORF">Y55F3BR.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294462.1">
        <property type="nucleotide sequence ID" value="NM_001307533.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBX0"/>
    <dbReference type="GeneID" id="190316"/>
    <dbReference type="KEGG" id="cel:CELE_Y55F3BR.5"/>
    <dbReference type="AGR" id="WB:WBGene00021942"/>
    <dbReference type="CTD" id="190316"/>
    <dbReference type="WormBase" id="Y55F3BR.5b">
        <property type="protein sequence ID" value="CE48756"/>
        <property type="gene ID" value="WBGene00021942"/>
        <property type="gene designation" value="madf-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1148072_0_0_1"/>
    <dbReference type="OrthoDB" id="5777370at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021942">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBX0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y55F3BR.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBX0"/>
        </source>
    </evidence>
    <sequence length="242" mass="28184" checksum="EF35158AA67666CF" modified="2013-12-11" version="1">MSQTPPKDENNELEFGIPTKRSRSGRPKKICAFSSFKCYEERDIEFFIHQVSDNQIIWDRRNSLNFDGNLVHATFDKIEICCQFLARKNGENASRLWTELASEYKREKARIEQLPSGIYSEEFEIRFPFMQQMWFLEIEASELKEADSNSLEETIVNFARQKSINDAPSPSSSLSAPIEHLNSSINRLIAVIDKKSEDTTKRQIPAKYSDIVEHLIGFLDKTPRERQMEVKCKIYNFLDTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBX2</accession>
    <name>U4PBX2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rnp-3</name>
        <name evidence="5" type="ORF">CELE_K08D10.3</name>
        <name evidence="7" type="ORF">K08D10.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294565.1">
        <property type="nucleotide sequence ID" value="NM_001307636.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBX2"/>
    <dbReference type="SMR" id="U4PBX2"/>
    <dbReference type="PeptideAtlas" id="U4PBX2"/>
    <dbReference type="GeneID" id="177182"/>
    <dbReference type="KEGG" id="cel:CELE_K08D10.3"/>
    <dbReference type="AGR" id="WB:WBGene00004386"/>
    <dbReference type="CTD" id="177182"/>
    <dbReference type="WormBase" id="K08D10.3b">
        <property type="protein sequence ID" value="CE48959"/>
        <property type="gene ID" value="WBGene00004386"/>
        <property type="gene designation" value="rnp-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041869_1_1_1"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004386">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBX2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="114"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="K08D10.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBX2"/>
        </source>
    </evidence>
    <sequence length="188" mass="21428" checksum="0A530AB1275B3969" modified="2013-12-11" version="1">MVFTQFGEIIQLMSFRKEKMRGQAHIVFKEVSSASNALRALQGFPFYGKPMRIQYAREDSDVISRAKGTFVEKRQKSTKIAKKPYEKPAKNGKSAAEPTQKEPQETDGPGLPNNILFCSNIPEGTEPEQIQTIFSQFPGLREVRWMPNTKDFAFIEYESEDLSEPARQALDNFRITPTQQITVKFASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBX5</accession>
    <name>U4PBX5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">eel-1</name>
        <name evidence="16" type="ORF">CELE_Y67D8C.5</name>
        <name evidence="18" type="ORF">Y67D8C.5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294467.1">
        <property type="nucleotide sequence ID" value="NM_001307538.3"/>
    </dbReference>
    <dbReference type="SMR" id="U4PBX5"/>
    <dbReference type="GeneID" id="177084"/>
    <dbReference type="AGR" id="WB:WBGene00022069"/>
    <dbReference type="CTD" id="177084"/>
    <dbReference type="WormBase" id="Y67D8C.5c">
        <property type="protein sequence ID" value="CE48686"/>
        <property type="gene ID" value="WBGene00022069"/>
        <property type="gene designation" value="eel-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022069">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBX5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14306">
        <property type="entry name" value="UBA_VP13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000126">
        <property type="entry name" value="Enhancer of EfL-1 mutant phenotype"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
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        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="ZC21.3d"/>
        </source>
    </evidence>
    <sequence length="271" mass="30372" checksum="19A8FE7101D766BA" modified="2013-12-11" version="1">MMLRVLVFTSLVALSIAQLTSSCPSCNTNSNYGAPSTTYSPTSTYGYSSQNYNPSSASSSNVYRNPSTSYGNTQQSNQNYVAYDTTNQNSPYYYQRVPSTAQYNSVLGVNAGFPQSSNQNQVLRDQSNNQGYMNNNQGMYNTQTTQGYGNNQGSYQNQMMYNNNNPQNTQTTTFLYASSIQPQQQQQQQQYNNQYNNQQMNSNGYNNQPMYDQSYSTQQYGSSTPSPQYSADSISCCSQVSSTCCYQTQQGYNTPSNNVQYSPSVYQYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBY7</accession>
    <name>U4PBY7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial protein M19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y48A5A.3</name>
        <name evidence="1 3" type="ORF">Y48A5A.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBY7"/>
    <dbReference type="SMR" id="U4PBY7"/>
    <dbReference type="PeptideAtlas" id="U4PBY7"/>
    <dbReference type="AGR" id="WB:WBGene00044466"/>
    <dbReference type="WormBase" id="Y48A5A.3b">
        <property type="protein sequence ID" value="CE48551"/>
        <property type="gene ID" value="WBGene00044466"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2040130_0_0_1"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044466">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBY7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y48A5A.3b"/>
        </source>
    </evidence>
    <sequence length="39" mass="4506" checksum="D3ABE4DE77F5C41A" modified="2013-12-11" version="1">MRLADLQAASSEESRKQMGLQPKVSIFKRLYRSVVPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC56</accession>
    <name>U4PC56_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTF3C1 extended winged-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tftc-1</name>
        <name evidence="3" type="ORF">CELE_Y38F2AR.5</name>
        <name evidence="5" type="ORF">Y38F2AR.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294529.1">
        <property type="nucleotide sequence ID" value="NM_001307600.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC56"/>
    <dbReference type="PeptideAtlas" id="U4PC56"/>
    <dbReference type="GeneID" id="177024"/>
    <dbReference type="AGR" id="WB:WBGene00021423"/>
    <dbReference type="CTD" id="177024"/>
    <dbReference type="WormBase" id="Y38F2AR.5b">
        <property type="protein sequence ID" value="CE48541"/>
        <property type="gene ID" value="WBGene00021423"/>
        <property type="gene designation" value="tftc-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005487_0_0_1"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021423">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC56">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="2">
        <location>
            <begin position="220"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y38F2AR.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="U4PC56"/>
        </source>
    </evidence>
    <sequence length="1013" mass="116712" checksum="B226E9649990CD0D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC61</accession>
    <name>U4PC61_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">cec-2</name>
        <name evidence="3" type="ORF">C50A2.2</name>
        <name evidence="1" type="ORF">CELE_C50A2.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294533.1">
        <property type="nucleotide sequence ID" value="NM_001307604.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC61"/>
    <dbReference type="GeneID" id="176934"/>
    <dbReference type="AGR" id="WB:WBGene00016796"/>
    <dbReference type="CTD" id="176934"/>
    <dbReference type="WormBase" id="C50A2.2d">
        <property type="protein sequence ID" value="CE49111"/>
        <property type="gene ID" value="WBGene00016796"/>
        <property type="gene designation" value="cec-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_601626_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016796">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC61">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C50A2.2d"/>
        </source>
    </evidence>
    <sequence length="185" mass="21232" checksum="77736EBB0359062C" modified="2013-12-11" version="1">MCAAVRSTRYDIRRDFRCLHNQYIDKRPRMCEWFSATGGGGSCGTTEICTFWNNDAGYLPNTHQRSKFHVDLSEFTGNNLGLLAFSMAWHEDFIDNNSGGPEIVKNNRFNAHIDVPCFTLWMNGKMCEKLENSHGLSIFRPLGTVLDVNELKIKITEHSSRFVAILPVFNLNSDWKNCFFPLENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC65</accession>
    <name>U4PC65_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LIn-26 Related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">lir-1</name>
        <name evidence="1" type="ORF">CELE_F18A1.3</name>
        <name evidence="3" type="ORF">F18A1.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380151.1">
        <property type="nucleotide sequence ID" value="NM_001393122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC65"/>
    <dbReference type="SMR" id="U4PC65"/>
    <dbReference type="GeneID" id="174240"/>
    <dbReference type="AGR" id="WB:WBGene00003044"/>
    <dbReference type="CTD" id="174240"/>
    <dbReference type="WormBase" id="F18A1.3j">
        <property type="protein sequence ID" value="CE48645"/>
        <property type="gene ID" value="WBGene00003044"/>
        <property type="gene designation" value="lir-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5775637at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003044">
        <property type="expression patterns" value="Expressed in embryo and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC65">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F18A1.3j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="U4PC65"/>
        </source>
    </evidence>
    <sequence length="237" mass="27063" checksum="384D8748B9F70C2D" modified="2013-12-11" version="1">MLLQLNDEERQRLMKMISTPGPQTLSMERIQMAPGQGQHILQQHQIPSTSSYTNNSFIYIKSDPQYKDEPQQQSNQFDATVNSVAHGQAGLSTLEMFACNGSPNGGDVLRRKTPSRKAEDSIKATCKVCGHDVMYSPQRTWNLMRHVWIMHQSSKPNQCSICGYSHIKPYVRKHIESQHKHDSNATIIDLKSPELEAEWSQLLDQCFGVTYRKWKHHKEDTQHTGGLLFDDDELRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC67</accession>
    <name>U4PC67_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F37C4.4</name>
        <name evidence="3 5" type="ORF">F37C4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AGR" id="WB:WBGene00017934"/>
    <dbReference type="CTD" id="177185"/>
    <dbReference type="WormBase" id="F30B5.4b">
        <property type="protein sequence ID" value="CE48830"/>
        <property type="gene ID" value="WBGene00017934"/>
        <property type="gene designation" value="osgn-1"/>
    </dbReference>
    <dbReference type="OMA" id="ASWDIQT"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC89">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
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    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF8">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F30B5.4b"/>
        </source>
    </evidence>
    <sequence length="485" mass="54472" checksum="39BB2BB6E76FE39E" modified="2013-12-11" version="1">MSKKSSHPPPSTSGNVKKSNFLSRITKKLRMHTGCCTTKFDTEVLIIGNGPAGIALSSFLSGMHPFYDATHPHENVTVHEKLLANHDFSLIDQDLSWSSNLTELSQSGRPLSVLYDMLVRPGADMGSDAPGCIQWELNRRREIPHMVIGETKIGGSWNEYDAEMLTVSFSDWMDMPGFTMEQWLGGRPLVKRLPSVAIATYLKKYVERLRLRKKFHQYFVVNSIKKIGDVWVTSGKRSTDGRSFVIRSKQVVVACGKTSPRKLQLPNEEHCSSNIVYDVRALKERLDATKKTVIDEDENYDTPSTSTCSPVIVVGDGVSSVDCVRHCLERDIPVVHVIRRTLRELRNVMLSRLSPIHYSEYTDIYRMMIGRSVHKNYQRVLDASITSVSKIHVEITTGSNREIIEMPYSTVAVCIGRESHFSTVFENAHTFLDYQSEQDETLFAVGAYAGDHFVRFLVGGCLRVAQHITGAANNNNVTAKLLPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC90</accession>
    <name>U4PC90_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">plx-1</name>
        <name evidence="7" type="ORF">CELE_Y55F3AL.1</name>
        <name evidence="9" type="ORF">Y55F3AL.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294557.1">
        <property type="nucleotide sequence ID" value="NM_001307628.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC90"/>
    <dbReference type="SMR" id="U4PC90"/>
    <dbReference type="PeptideAtlas" id="U4PC90"/>
    <dbReference type="GeneID" id="246019"/>
    <dbReference type="AGR" id="WB:WBGene00004047"/>
    <dbReference type="CTD" id="246019"/>
    <dbReference type="WormBase" id="Y55F3AL.1e">
        <property type="protein sequence ID" value="CE48755"/>
        <property type="gene ID" value="WBGene00004047"/>
        <property type="gene designation" value="plx-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001436_2_0_1"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004047">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC90">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01180">
        <property type="entry name" value="IPT_plexin_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12790">
        <property type="entry name" value="RasGAP_plexin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000033">
        <property type="entry name" value="PLeXin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000036">
        <property type="entry name" value="PLeXin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002307">
        <property type="entry name" value="PLeXin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002451">
        <property type="entry name" value="PLeXin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000421">
        <property type="entry name" value="Plexin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="5">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="106"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="202"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="290"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="389"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDH93356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y55F3AL.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="U4PC90"/>
        </source>
    </evidence>
    <sequence length="1174" mass="131138" checksum="0C1F842F1897E2F4" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC94</accession>
    <name>U4PC94_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">famp-1</name>
        <name evidence="1" type="ORF">CELE_M70.4</name>
        <name evidence="3" type="ORF">M70.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368349.1">
        <property type="nucleotide sequence ID" value="NM_001380086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC94"/>
    <dbReference type="GeneID" id="177015"/>
    <dbReference type="KEGG" id="cel:CELE_M70.4"/>
    <dbReference type="AGR" id="WB:WBGene00019786"/>
    <dbReference type="CTD" id="177015"/>
    <dbReference type="WormBase" id="M70.4b">
        <property type="protein sequence ID" value="CE48727"/>
        <property type="gene ID" value="WBGene00019786"/>
        <property type="gene designation" value="famp-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019668_0_0_1"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019786">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC94">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="M70.4b"/>
        </source>
    </evidence>
    <sequence length="34" mass="4101" checksum="A86E47D14787BB0A" modified="2013-12-11" version="1">MYWTPKILRSNRVFRFSLHQAIEVIIVADNLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>U4PC95</accession>
    <name>U4PC95_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle collagen 99</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">col-99</name>
        <name evidence="4" type="ORF">CELE_F29C4.8</name>
        <name evidence="6" type="ORF">F29C4.8</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294561.1">
        <property type="nucleotide sequence ID" value="NM_001307632.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PC95"/>
    <dbReference type="GeneID" id="185112"/>
    <dbReference type="AGR" id="WB:WBGene00000674"/>
    <dbReference type="CTD" id="185112"/>
    <dbReference type="WormBase" id="F29C4.8c">
        <property type="protein sequence ID" value="CE48782"/>
        <property type="gene ID" value="WBGene00000674"/>
        <property type="gene designation" value="col-99"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001074_21_1_1"/>
    <dbReference type="OrthoDB" id="8964326at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000674">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PC95">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF423">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDH93361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F29C4.8c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="U4PC95"/>
        </source>
    </evidence>
    <sequence length="695" mass="70149" checksum="9E5E7BC8E987E28B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKP0</accession>
    <name>V6CKP0_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Exportin-2 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xpo-2</name>
        <name evidence="3" type="ORF">CELE_Y48G1A.5</name>
        <name evidence="5" type="ORF">Y48G1A.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293261.1">
        <property type="nucleotide sequence ID" value="NM_001306332.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKP0"/>
    <dbReference type="SMR" id="V6CKP0"/>
    <dbReference type="PeptideAtlas" id="V6CKP0"/>
    <dbReference type="GeneID" id="171621"/>
    <dbReference type="KEGG" id="cel:CELE_Y48G1A.5"/>
    <dbReference type="AGR" id="WB:WBGene00002079"/>
    <dbReference type="CTD" id="171621"/>
    <dbReference type="WormBase" id="Y48G1A.5b">
        <property type="protein sequence ID" value="CE49337"/>
        <property type="gene ID" value="WBGene00002079"/>
        <property type="gene designation" value="xpo-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009614_0_0_1"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002079">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKP0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004744507" evidence="1">
        <location>
            <begin position="37"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-2 C-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y48G1A.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="V6CKP0"/>
        </source>
    </evidence>
    <sequence length="195" mass="21529" checksum="DAA0AC0FDDF108C1" modified="2014-02-19" version="1">MTFVLNTMFRRVQSSKTPKFMKLFIVFLCRFTIARSAQDLVQSCENIQTGMFGMLIEKVVCIDLPGLKQTTTGPEKRIIAIGMGNLLADVTQQLVGQYGILSYEVAMLLEAASASDRAVLSPEEEQASMYNAEGEFVNPFCRLSYAPKQPPVAANIANHKAYFAQAVLVRGPGNCPETLRSVPPEIVTYLQSIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKQ0</accession>
    <name>V6CKQ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CHCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_ZK616.3</name>
        <name evidence="1 3" type="ORF">ZK616.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKQ0"/>
    <dbReference type="SMR" id="V6CKQ0"/>
    <dbReference type="PeptideAtlas" id="V6CKQ0"/>
    <dbReference type="AGR" id="WB:WBGene00022773"/>
    <dbReference type="WormBase" id="ZK616.3b">
        <property type="protein sequence ID" value="CE49420"/>
        <property type="gene ID" value="WBGene00022773"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1898173_0_0_1"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022773">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKQ0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="ZK616.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="V6CKQ0"/>
        </source>
    </evidence>
    <sequence length="51" mass="6035" checksum="C7BE906AB306CD82" modified="2014-02-19" version="1">MKSDDTRDPSEKCPNQFVNWAACMQNMSDERREQMRKAMTVDTEELKINPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKR7</accession>
    <name>V6CKR7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Raf homolog serine/threonine-protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Abnormal cell lineage protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">lin-45</name>
        <name evidence="20" type="ORF">CELE_Y73B6A.5</name>
        <name evidence="22" type="ORF">Y73B6A.5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with cdf-1 in a zinc-dependent manner which promotes its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293842.1">
        <property type="nucleotide sequence ID" value="NM_001306913.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKR7"/>
    <dbReference type="SMR" id="V6CKR7"/>
    <dbReference type="GeneID" id="177436"/>
    <dbReference type="AGR" id="WB:WBGene00003030"/>
    <dbReference type="CTD" id="177436"/>
    <dbReference type="WormBase" id="Y73B6A.5d">
        <property type="protein sequence ID" value="CE49237"/>
        <property type="gene ID" value="WBGene00003030"/>
        <property type="gene designation" value="lin-45"/>
    </dbReference>
    <dbReference type="OrthoDB" id="774951at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003030">
        <property type="expression patterns" value="Expressed in material anatomical entity and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKR7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20811">
        <property type="entry name" value="C1_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14062">
        <property type="entry name" value="STKc_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000024">
        <property type="entry name" value="B-Raf proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000366">
        <property type="entry name" value="Raf homolog serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF262">
        <property type="entry name" value="RAF HOMOLOG SERINE_THREONINE-PROTEIN KINASE RAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    <sequence length="131" mass="14697" checksum="45AC85E7550BDD83" modified="2015-12-09" version="1">MWNPKETKQSINRMTGHMQLVNQVVFSPDTRYIASASFDKSVKLWCGRTGKYLASLRGHVGPVYQVAWSADSRLLVSGSADSTLKVFELKTKSLYYDLPGHGDEVFTVDWSPEGTKVVSGGKDKVLKLWRQ</sequence>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317830.1">
        <property type="nucleotide sequence ID" value="NM_001330819.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H9I9"/>
    <dbReference type="SMR" id="A0A168H9I9"/>
    <dbReference type="GeneID" id="187099"/>
    <dbReference type="KEGG" id="cel:CELE_K07C6.11"/>
    <dbReference type="AGR" id="WB:WBGene00005959"/>
    <dbReference type="CTD" id="187099"/>
    <dbReference type="WormBase" id="K07C6.11b">
        <property type="protein sequence ID" value="CE51588"/>
        <property type="gene ID" value="WBGene00005959"/>
        <property type="gene designation" value="srx-68"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5825164at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005959">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A168H9I9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SAP35592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K07C6.11b"/>
        </source>
    </evidence>
    <sequence length="137" mass="15852" checksum="3635FE41E024D02D" modified="2016-07-06" version="1">MIGWYGDFLKNAVIVAVVVSLDILTVIKVRFSRKKIQARVNQENQNKLSQRDIRFLKQAVFQASVFMLELLTYFFFPLYFQNRWVVFFGTSFAWVAVHAADGMVVIVCNPEVRKFLMNKKTNSMNSTASRTTNLNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DQL6</accession>
    <name>A0A3B1DQL6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Degenerin del-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">del-1</name>
        <name evidence="15" type="ORF">CELE_E02H4.1</name>
        <name evidence="17" type="ORF">E02H4.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355470.1">
        <property type="nucleotide sequence ID" value="NM_001368545.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1DQL6"/>
    <dbReference type="GeneID" id="181534"/>
    <dbReference type="AGR" id="WB:WBGene00000952"/>
    <dbReference type="CTD" id="181534"/>
    <dbReference type="WormBase" id="E02H4.1b">
        <property type="protein sequence ID" value="CE52781"/>
        <property type="gene ID" value="WBGene00000952"/>
        <property type="gene designation" value="del-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000952">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1DQL6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004726">
        <property type="entry name" value="Deg-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00867">
        <property type="entry name" value="deg-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VAY52606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="E02H4.1b"/>
        </source>
    </evidence>
    <sequence length="669" mass="75867" checksum="5814FDFD965BD3CE" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DQN5</accession>
    <name>A0A3B1DQN5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mec-2</name>
        <name evidence="6" type="ORF">CELE_F14D12.4</name>
        <name evidence="8" type="ORF">F14D12.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355480.1">
        <property type="nucleotide sequence ID" value="NM_001368514.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1DQN5"/>
    <dbReference type="SMR" id="A0A3B1DQN5"/>
    <dbReference type="GeneID" id="180826"/>
    <dbReference type="AGR" id="WB:WBGene00003166"/>
    <dbReference type="CTD" id="180826"/>
    <dbReference type="WormBase" id="F14D12.4l">
        <property type="protein sequence ID" value="CE52691"/>
        <property type="gene ID" value="WBGene00003166"/>
        <property type="gene designation" value="mec-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003166">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1DQN5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03403">
        <property type="entry name" value="SPFH_stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="72"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VAY52616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F14D12.4l"/>
        </source>
    </evidence>
    <sequence length="325" mass="36034" checksum="A1990E467B102E7F" modified="2018-12-05" version="1">MYDDPAERKFSVPPPREFKFSPYIPRIHTDVKRPPTEPLGANIQNEFGVCGWILTILSYLLIFFTLPISACMCIKVVQEYERAVIFRLGRLMPGGAKGPGIFFIVPCIDTYRKVDLRVLSFEVPPQEILSKDSVTVAVDAVVYFRISNATISVTNVEDAARSTKLLAQTTLRNILGTKTLAEMLSDREAISHQMQTTLDEATEPWGVKVERVEVKDVRLPVQLQRAMAAEAEAAREARAKVIVAEGEQKASRALKEAAEVIAESPSALQLRYLQTLNSISAEKNSTIIFPFPIDLLSAFLQRTPPKVDNNFAFPTHKAGGIPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DQY8</accession>
    <name>A0A3B1DQY8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F43D2.7</name>
        <name evidence="2 4" type="ORF">F43D2.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="VAY52528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1DQY8"/>
    <dbReference type="AGR" id="WB:WBGene00045516"/>
    <dbReference type="WormBase" id="F43D2.7a">
        <property type="protein sequence ID" value="CE52779"/>
        <property type="gene ID" value="WBGene00045516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00045516">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1DQY8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VAY52528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F43D2.7a"/>
        </source>
    </evidence>
    <sequence length="90" mass="10748" checksum="62EB77137CF5764C" modified="2018-12-05" version="1">MKYWVIILYFIGKFIFANSNVKCPKNSIEKELECAIKCCSSFVRFNFIAIGLISFIVISILFSFFCWLYRCCIPQRYDSVQYRYQQHVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DR12</accession>
    <name>A0A3B1DR12_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">madd-3</name>
        <name evidence="10" type="ORF">CELE_E02H4.3</name>
        <name evidence="12" type="ORF">E02H4.3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355453.1">
        <property type="nucleotide sequence ID" value="NM_001368549.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1DR12"/>
    <dbReference type="SMR" id="A0A3B1DR12"/>
    <dbReference type="GeneID" id="3565068"/>
    <dbReference type="AGR" id="WB:WBGene00006517"/>
    <dbReference type="CTD" id="3565068"/>
    <dbReference type="WormBase" id="E02H4.3d">
        <property type="protein sequence ID" value="CE52777"/>
        <property type="gene ID" value="WBGene00006517"/>
        <property type="gene designation" value="madd-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006517">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1DR12">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="257"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VAY52580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="E02H4.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="A0A3B1DR12"/>
        </source>
    </evidence>
    <sequence length="593" mass="67046" checksum="754AAB5CDD0B3F56" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V0INA2</accession>
    <name>A0A4V0INA2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fln-2</name>
        <name evidence="8" type="ORF">C23F12.1</name>
        <name evidence="6" type="ORF">CELE_C23F12.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VTW47489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360665.1">
        <property type="nucleotide sequence ID" value="NM_001373426.2"/>
    </dbReference>
    <dbReference type="SMR" id="A0A4V0INA2"/>
    <dbReference type="GeneID" id="181168"/>
    <dbReference type="AGR" id="WB:WBGene00016006"/>
    <dbReference type="CTD" id="181168"/>
    <dbReference type="WormBase" id="C23F12.1t">
        <property type="protein sequence ID" value="CE53384"/>
        <property type="gene ID" value="WBGene00016006"/>
        <property type="gene designation" value="fln-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A4V0INA2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21227">
        <property type="entry name" value="CH_jitterbug-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21229">
        <property type="entry name" value="CH_jitterbug-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001145">
        <property type="entry name" value="Jitterbug, isoform I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF16">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="23"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="14"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="125"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="331"/>
            <end position="424"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <organism evidence="14 15">
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
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    <dbReference type="EMBL" id="BX284606">
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    </dbReference>
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    <dbReference type="GeneID" id="188854"/>
    <dbReference type="AGR" id="WB:WBGene00020767"/>
    <dbReference type="CTD" id="188854"/>
    <dbReference type="WormBase" id="T24D8.1d">
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        <property type="gene ID" value="WBGene00020767"/>
        <property type="gene designation" value="lgc-40"/>
    </dbReference>
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    <sequence length="487" mass="56237" checksum="19E8E0072B1788A3" modified="2022-10-12" version="1">MKLHTMIRFLLSVCCIVNVFESADLAFIPLTKAFLDKLKNETLYNRFATPTQYDGVPTNVTLSMFIEGMSSFSAQTMDYHLDVYFQEEWYDHRLAHNASAPILVRDLTVFKMMWHPDVYFANARSAAFQDITDDNFLVWVYPNGRVWYDARISIVSSCNMDLWKYPLDSQECALRILSYAYPMTVLRLLWSEKEDVPAIDRNPDITMPDMSLKHIRTGYCNGTYATGEWSCMTAIFYVEREMMHHVMQTYVPTALIVVISWFNFWLEIDSAPARVSLSITTLLTISTQANAVKLALPEVSYMKAIDVWMGSCMAFVFGVMIEFTICHYAKNLEMLRGDGQPSLIVDTALSTLFGAARDIDDLNEEEGVRGDGEQHIALNMLNPEEPRLRSLNQNNDVTANGTRYFVGAERMKRKRSKASLSRLRQQVASMRHATIDVSRRAFNWTRALRNLRGRRVAQRIDERCRIVFPMIFLLFNVAYWSFYLVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-03-20" modified="2025-10-08" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPK2</accession>
    <name>A3FPK2_CAEEL</name>
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        <submittedName>
            <fullName evidence="16">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </submittedName>
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        <name evidence="18" type="ORF">ZC506.4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
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        <property type="protein sequence ID" value="CAM33507.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="WBGene00003232"/>
        <property type="gene designation" value="mgl-1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="8 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005659414" evidence="14">
        <location>
            <begin position="20"/>
            <end position="938"/>
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    </feature>
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        <location>
            <begin position="619"/>
            <end position="645"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="731"/>
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    </feature>
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        <location>
            <begin position="808"/>
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    </feature>
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        <location>
            <begin position="850"/>
            <end position="868"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="15">
        <location>
            <begin position="620"/>
            <end position="882"/>
        </location>
    </feature>
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        <location>
            <begin position="914"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
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    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAM33507.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="ZC506.4b"/>
        </source>
    </evidence>
    <sequence length="938" mass="105849" checksum="BDEF5D2788C7A816" modified="2015-11-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-05-15" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>A4UVJ6</accession>
    <name>A4UVJ6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pcyt-2.2</name>
        <name evidence="8" type="ORF">C39D10.3</name>
        <name evidence="6" type="ORF">CELE_C39D10.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="3"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041227.1">
        <property type="nucleotide sequence ID" value="NM_001047762.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A4UVJ6"/>
    <dbReference type="SMR" id="A4UVJ6"/>
    <dbReference type="IntAct" id="A4UVJ6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="A4UVJ6"/>
    <dbReference type="GeneID" id="181047"/>
    <dbReference type="UCSC" id="C39D10.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016531"/>
    <dbReference type="CTD" id="181047"/>
    <dbReference type="WormBase" id="C39D10.3b">
        <property type="protein sequence ID" value="CE39689"/>
        <property type="gene ID" value="WBGene00016531"/>
        <property type="gene designation" value="pcyt-2.2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031246_1_0_1"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016531">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A4UVJ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF3">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="5">
        <location>
            <begin position="64"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD63854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="C39D10.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A4UVJ6"/>
        </source>
    </evidence>
    <sequence length="213" mass="23800" checksum="F146125AA3858B7A" modified="2007-05-15" version="1">MLVTKKHHMETDSILDFKSAILPFALDPLSNEPVISVSLFKQNYTFAPVVIGRKPKVTDKVVYVSGAFDLFHAGHLSFLEAAKDLGDYLIVGIVGDDDVNEEKGTIFPVMNLLERTLNISSLKIVDEVFVGVPAVTNSKFVNLIRASKIAVYSETHPRRFADCTYHRIIEEVTPDYDATCEEILERITSRKIASSDDDEIAMFNAVPLNNNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-05-15" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>A4UVK0</accession>
    <name>A4UVK0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">him-4</name>
        <name evidence="11" type="ORF">CELE_F15G9.4</name>
        <name evidence="13" type="ORF">F15G9.4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAM84806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123132.1">
        <property type="nucleotide sequence ID" value="NM_001129660.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A4UVK0"/>
    <dbReference type="PeptideAtlas" id="A4UVK0"/>
    <dbReference type="GeneID" id="181187"/>
    <dbReference type="UCSC" id="F15G9.4b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001863"/>
    <dbReference type="CTD" id="181187"/>
    <dbReference type="WormBase" id="F15G9.4c">
        <property type="protein sequence ID" value="CE40845"/>
        <property type="gene ID" value="WBGene00001863"/>
        <property type="gene designation" value="him-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000087_0_0_1"/>
    <dbReference type="OrthoDB" id="5985519at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001863">
        <property type="expression patterns" value="Expressed in musculature of body wall and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A4UVK0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000953">
        <property type="entry name" value="High Incidence of Males (Increased X chromosome loss)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051505">
        <property type="entry name" value="C-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789">
        <property type="entry name" value="CHONDROLECTIN VARIANT CHODLFDELTAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAM84806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F15G9.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A4UVK0"/>
        </source>
    </evidence>
    <sequence length="212" mass="23496" checksum="28765A4BD7CB4FBB" modified="2007-05-15" version="1">MNPHTRICEDLDECAFYQPCDFECINYDGGFQCNCPLGYELAEEGCRDVNECESVRCEDGKACFNQLGGYECIDDPCPANYSLVDDRYCEPECENCTSTPIQVHMLAIPSGLPISHIATLTAYDKSGRVLNDTTYAISDTGAPLARGRMTSGPFTIKAVKRGHAQVWTNRVLAAGDHHKVRVRAHSDHATNELHAPKETNFLVLINVGQYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-05-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A4UVM4</accession>
    <name>A4UVM4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_R06A10.5</name>
        <name evidence="1 3" type="ORF">R06A10.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD73238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001248959.1">
        <property type="nucleotide sequence ID" value="NM_001262030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A4UVM4"/>
    <dbReference type="GeneID" id="4926918"/>
    <dbReference type="UCSC" id="R06A10.5">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00044895"/>
    <dbReference type="CTD" id="4926918"/>
    <dbReference type="WormBase" id="R06A10.5a">
        <property type="protein sequence ID" value="CE40309"/>
        <property type="gene ID" value="WBGene00044895"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1951356_0_0_1"/>
    <dbReference type="OrthoDB" id="5828885at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044895">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A4UVM4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD73238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="R06A10.5a"/>
        </source>
    </evidence>
    <sequence length="60" mass="7323" checksum="8A02448729704781" modified="2007-05-15" version="1">MKDVLEEDFSDLWHESEFCMAFLALQDEHQRFTRLAKSNSNGENPRRFHWANRYARIHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-09-11" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>A7DTF3</accession>
    <name>A7DTF3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">obr-1</name>
        <name evidence="6" type="ORF">CELE_Y47D3A.17</name>
        <name evidence="8" type="ORF">Y47D3A.17</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAO82060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122730.1">
        <property type="nucleotide sequence ID" value="NM_001129258.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7DTF3"/>
    <dbReference type="SMR" id="A7DTF3"/>
    <dbReference type="PeptideAtlas" id="A7DTF3"/>
    <dbReference type="GeneID" id="176555"/>
    <dbReference type="KEGG" id="cel:CELE_Y47D3A.17"/>
    <dbReference type="UCSC" id="Y47D3A.17d">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012930"/>
    <dbReference type="CTD" id="176555"/>
    <dbReference type="WormBase" id="Y47D3A.17d">
        <property type="protein sequence ID" value="CE24330"/>
        <property type="gene ID" value="WBGene00012930"/>
        <property type="gene designation" value="obr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007105_6_1_1"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012930">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A7DTF3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000026">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAO82060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y47D3A.17d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A7DTF3"/>
        </source>
    </evidence>
    <sequence length="449" mass="51265" checksum="EC9EE6973B70EBF5" modified="2007-09-11" version="1">MPCSNSNGPPATAGVHLTPTKRHIGAGDPSSSTCSDSGAVVVVGAHKGGRQRRTTVPERPNLPINLWSIMKNCIGKELSKIPMPVNFSEPISVLQRVTEDLEYANLLETGAKLSTLEQMCYVAAYAASNYSTTCHRTNKPFNPLLGETFEFDRMDDLGWRSVTEQVSHHPPAAAHHAEGNGWTMYQDFTMTSRFRGKYLSVIPIGFTHVVFPATKSHFSYRKITTTVHNIIVGKLWIDNHGDMEITNHETNEKCLLKFVPYSYFSREQPRKVYGIVRDAEGIPKYVVQGTWDKSIDMLKVSSWNGNHEKPKLEVDETSLKRIWTANPLPKNAEKMHNFTKLAIELNEPEEGVAPTDSRLRPDQRLMENGEWDEANRKKLEIEEKQRVVRRRREAEKELAMKKGDKYEEYEPTWFVRVQDESNGALIHQFKGGYWEAKEQQNWEKCPDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-09-11" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A7DTF6</accession>
    <name>A7DTF6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y66D12A.16</name>
        <name evidence="2 4" type="ORF">Y66D12A.16</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAO82055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122736.1">
        <property type="nucleotide sequence ID" value="NM_001129264.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7DTF6"/>
    <dbReference type="PeptideAtlas" id="A7DTF6"/>
    <dbReference type="GeneID" id="190499"/>
    <dbReference type="KEGG" id="cel:CELE_Y66D12A.16"/>
    <dbReference type="UCSC" id="Y66D12A.16b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013442"/>
    <dbReference type="CTD" id="190499"/>
    <dbReference type="WormBase" id="Y66D12A.16a">
        <property type="protein sequence ID" value="CE41480"/>
        <property type="gene ID" value="WBGene00013442"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TIWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1697100_0_0_1"/>
    <dbReference type="OrthoDB" id="5876404at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013442">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A7DTF6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAO82055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y66D12A.16a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A7DTF6"/>
        </source>
    </evidence>
    <sequence length="158" mass="18202" checksum="CB8159468DFC5CCD" modified="2007-09-11" version="1">MFGKGAGSFFDDKPSSDSEDQKDVKKANQAARDSYYGAYSYATQDFSSSRGLSRDMEQLKSPAKSESNGTLRSEHQWRDKRRENHRRPLKEHHRRNETRRDYRSISAVETVHETIKIESRRTVACEGNVYFEETNVIQFPKNLPPNVHVITAAQYGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-09-11" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A7DTF7</accession>
    <name>A7DTF7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y66D12A.16</name>
        <name evidence="2 4" type="ORF">Y66D12A.16</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAO82056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122737.1">
        <property type="nucleotide sequence ID" value="NM_001129265.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7DTF7"/>
    <dbReference type="SMR" id="A7DTF7"/>
    <dbReference type="GeneID" id="190499"/>
    <dbReference type="UCSC" id="Y66D12A.16b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013442"/>
    <dbReference type="CTD" id="190499"/>
    <dbReference type="WormBase" id="Y66D12A.16b">
        <property type="protein sequence ID" value="CE41481"/>
        <property type="gene ID" value="WBGene00013442"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876404at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013442">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A7DTF7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAO82056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y66D12A.16b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A7DTF7"/>
        </source>
    </evidence>
    <sequence length="155" mass="17931" checksum="E5DE150A286D4E6D" modified="2007-09-11" version="1">MFGKGAGSFFDDKPSSDSEDQKDVKKANQAARDSYYGAYSYATQDFSSSRGLSRDMEQLKSPAKSESNGTLRSEHQWRDKRRENHRRPLKEHHRRNETRRDYRSVETVHETIKIESRRTVACEGNVYFEETNVIQFPKNLPPNVHVITAAQYGSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-02-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3MU46-2</accession>
    <name>NLP38_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform a of Neuropeptide-like protein 38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Myoinhibitory-like protein homolog</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">MIP-1-1</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">MIP-1-2</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">MIP-1-5</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="primary">mihp-1</name>
        <name evidence="5" type="synonym">mip-1</name>
        <name evidence="5" type="synonym">nlp-38</name>
        <name evidence="5" type="ORF">C01A2.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2019" name="PLoS Genet." volume="15" first="E1007945" last="E1007945">
            <title>Myoinhibitory peptide signaling modulates aversive gustatory learning in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Peymen K."/>
                <person name="Watteyne J."/>
                <person name="Borghgraef C."/>
                <person name="Van Sinay E."/>
                <person name="Beets I."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="30779740"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1007945"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>AMIDATION AT TRP-35; TRP-60 AND TRP-118</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G3MU46-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_060479"/>
        </isoform>
        <isoform>
            <id>G3MU46-1</id>
            <name evidence="5">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001252155.1">
        <property type="nucleotide sequence ID" value="NM_001265226.2"/>
    </dbReference>
    <dbReference type="WormBase" id="C01A2.7a">
        <property type="protein sequence ID" value="CE30236"/>
        <property type="gene ID" value="WBGene00007219"/>
        <property type="gene designation" value="mihp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="30779740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C01A2.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C01A2.7b"/>
        </source>
    </evidence>
    <sequence length="101" mass="11509" checksum="D0D79E768016598D" modified="2011-11-16" version="1" precursor="true">MQLIHFIVGLAMLISLSLAASDDRVLGWNKAHGLWGKRSVQEASQDKRTPQNWNKLNSLWGKRSASSFDDDYTTENGDDDVTMLYKRSPAQWQRANGLWGR</sequence>
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            <fullName evidence="3">Isoform c of Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6</fullName>
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            <fullName evidence="1">Myotubularin-related protein 6</fullName>
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        <alternativeName>
            <fullName evidence="2">Phosphatidylinositol-3-phosphate phosphatase</fullName>
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    <gene>
        <name evidence="6" type="primary">mtm-6</name>
        <name evidence="6" type="synonym">cup-6</name>
        <name evidence="6" type="ORF">F53A2.8</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2003" name="J. Biol. Chem." volume="278" first="34380" last="34386">
            <title>Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Xue Y."/>
                <person name="Fares H."/>
                <person name="Grant B."/>
                <person name="Li Z."/>
                <person name="Rose A.M."/>
                <person name="Clark S.G."/>
                <person name="Skolnik E.Y."/>
            </authorList>
            <dbReference type="PubMed" id="12788949"/>
            <dbReference type="DOI" id="10.1074/jbc.M303259200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2004" name="Mol. Biol. Cell" volume="15" first="189" last="196">
            <title>Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dang H."/>
                <person name="Li Z."/>
                <person name="Skolnik E.Y."/>
                <person name="Fares H."/>
            </authorList>
            <dbReference type="PubMed" id="14565969"/>
            <dbReference type="DOI" id="10.1091/mbc.E03-08-0605"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MTM-9</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF CYS-335</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2010" name="EMBO J." volume="29" first="4094" last="4105">
            <title>Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells.</title>
            <authorList>
                <person name="Silhankova M."/>
                <person name="Port F."/>
                <person name="Harterink M."/>
                <person name="Basler K."/>
                <person name="Korswagen H.C."/>
            </authorList>
            <dbReference type="PubMed" id="21076391"/>
            <dbReference type="DOI" id="10.1038/emboj.2010.278"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF CYS-335 AND ASP-340</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E114501" last="E114501">
            <title>MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ericson V.R."/>
                <person name="Spilker K.A."/>
                <person name="Tugizova M.S."/>
                <person name="Shen K."/>
            </authorList>
            <dbReference type="PubMed" id="25479419"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0114501"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF CYS-335</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5ED68-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5ED68-2</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_058287"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="3"/>
    <dbReference type="RefSeq" id="NP_001022602.1">
        <property type="nucleotide sequence ID" value="NM_001027431.7"/>
    </dbReference>
    <dbReference type="WormBase" id="F53A2.8c">
        <property type="protein sequence ID" value="CE37116"/>
        <property type="gene ID" value="WBGene00003478"/>
        <property type="gene designation" value="mtm-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9Y217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="12788949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAP79302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F53A2.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F53A2.8c"/>
        </source>
    </evidence>
    <sequence length="674" mass="77123" checksum="DA03C650085C8CA5" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>G5EDJ0-2</accession>
    <name>FAX1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Nuclear hormone receptor family member fax-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fax-1</name>
        <name evidence="4" type="ORF">F56E3.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="1997" name="Development" volume="124" first="2571" last="2580">
            <title>Genes that guide growth cones along the C. elegans ventral nerve cord.</title>
            <authorList>
                <person name="Wightman B."/>
                <person name="Baran R."/>
                <person name="Garriga G."/>
            </authorList>
            <dbReference type="PubMed" id="9216999"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 128-ARG--ILE-419</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2000" name="Development" volume="127" first="703" last="712">
            <title>The fax-1 nuclear hormone receptor regulates axon pathfinding and neurotransmitter expression.</title>
            <authorList>
                <person name="Much J.W."/>
                <person name="Slade D.J."/>
                <person name="Klampert K."/>
                <person name="Garriga G."/>
                <person name="Wightman B."/>
            </authorList>
            <dbReference type="PubMed" id="10648229"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 128-ARG--ILE-419</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2005" name="Dev. Biol." volume="287" first="74" last="85">
            <title>The C. elegans nuclear receptor gene fax-1 and homeobox gene unc-42 coordinate interneuron identity by regulating the expression of glutamate receptor subunits and other neuron-specific genes.</title>
            <authorList>
                <person name="Wightman B."/>
                <person name="Ebert B."/>
                <person name="Carmean N."/>
                <person name="Weber K."/>
                <person name="Clever S."/>
            </authorList>
            <dbReference type="PubMed" id="16183052"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2005.08.032"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 128-ARG--ILE-419</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2008" name="BMC Mol. Biol." volume="9" first="2" last="2">
            <title>Specificity of DNA-binding by the FAX-1 and NHR-67 nuclear receptors of Caenorhabditis elegans is partially mediated via a subclass-specific P-box residue.</title>
            <authorList>
                <person name="DeMeo S.D."/>
                <person name="Lombel R.M."/>
                <person name="Cronin M."/>
                <person name="Smith E.L."/>
                <person name="Snowflack D.R."/>
                <person name="Reinert K."/>
                <person name="Clever S."/>
                <person name="Wightman B."/>
            </authorList>
            <dbReference type="PubMed" id="18179707"/>
            <dbReference type="DOI" id="10.1186/1471-2199-9-2"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2012" name="BMC Evol. Biol." volume="12" first="81" last="81">
            <title>Analysis of C. elegans NR2E nuclear receptors defines three conserved clades and ligand-independent functions.</title>
            <authorList>
                <person name="Weber K.P."/>
                <person name="Alvaro C.G."/>
                <person name="Baer G.M."/>
                <person name="Reinert K."/>
                <person name="Cheng G."/>
                <person name="Clever S."/>
                <person name="Wightman B."/>
            </authorList>
            <dbReference type="PubMed" id="22690911"/>
            <dbReference type="DOI" id="10.1186/1471-2148-12-81"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF 128-ARG--ILE-419</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EDJ0-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061077 VSP_061076"/>
        </isoform>
        <isoform>
            <id>G5EDJ0-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001263953.1">
        <property type="nucleotide sequence ID" value="NM_001277024.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F56E3.4b">
        <property type="protein sequence ID" value="CE04670"/>
        <property type="gene ID" value="WBGene00001400"/>
        <property type="gene designation" value="fax-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAD55066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F56E3.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F56E3.4b"/>
        </source>
    </evidence>
    <sequence length="390" mass="43569" checksum="263EE0F933414CDC" modified="2011-12-14" version="1">MSDEDEPLNFSTSKATEESKEGILGVRSIFNTPLLFPPPMFNAGVISPHIAAALAMSFNQQRMNASVSPPLDHTTISVNSFPSMGSVKTDSPPTASSPTLCCAVCGDVSSGKHYGILACNGCSGFFKRSVRRRLIYRCQAGTGNCVVDKAHRNQCQACRLKKCLNKGMNKDAVQNERQPRNTATIRPALDMDPQNFFREYAGAVSAIMGHSNMMKREDSPSSASDGKTEDEKKDSLQETTMSQLESVLQWAQQFRLFTVLTNSEKRQIILTQWPRLLCISLCEQAEDVSFDDHLTSLMLKFRRLDVSPAEFNCLKAITIFMKPTEDSQYQFEEQLDQCICLLQQCCLKLDSSPSRFGKLLLLLAEIQFYPTSYLESLLDTKISQLVSRFL</sequence>
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<entry dataset="Swiss-Prot" created="2020-10-07" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>G5EEL0-2</accession>
    <name>LIDB1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform b of LIM domain-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ldb-1</name>
        <name evidence="5" type="ORF">F58A3.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="1996-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Hobert O."/>
                <person name="Kohara Y."/>
                <person name="Ruvkun G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2000" name="Dev. Biol." volume="226" first="45" last="56">
            <title>The Caenorhabditis elegans Ldb/NLI/Clim orthologue ldb-1 is required for neuronal function.</title>
            <authorList>
                <person name="Cassata G."/>
                <person name="Roehrig S."/>
                <person name="Kuhn F."/>
                <person name="Hauri H.P."/>
                <person name="Baumeister R."/>
                <person name="Buerglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="10993673"/>
            <dbReference type="DOI" id="10.1006/dbio.2000.9846"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2003" name="Development" volume="130" first="2589" last="2601">
            <title>The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development.</title>
            <authorList>
                <person name="Gupta B.P."/>
                <person name="Wang M."/>
                <person name="Sternberg P.W."/>
            </authorList>
            <dbReference type="PubMed" id="12736204"/>
            <dbReference type="DOI" id="10.1242/dev.00500"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2011" name="Development" volume="138" first="87" last="96">
            <title>Regulation of C. elegans presynaptic differentiation and neurite branching via a novel signaling pathway initiated by SAM-10.</title>
            <authorList>
                <person name="Zheng Q."/>
                <person name="Schaefer A.M."/>
                <person name="Nonet M.L."/>
            </authorList>
            <dbReference type="PubMed" id="21115607"/>
            <dbReference type="DOI" id="10.1242/dev.055350"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2020" name="Biochim. Biophys. Acta" volume="1863" first="194577" last="194577">
            <title>LDB1 and the SWI/SNF complex participate in both transcriptional activation and repression by Caenorhabditis elegans BLIMP1/PRDM1.</title>
            <authorList>
                <person name="Fong H.T."/>
                <person name="Hagen T."/>
                <person name="Inoue T."/>
            </authorList>
            <dbReference type="PubMed" id="32417234"/>
            <dbReference type="DOI" id="10.1016/j.bbagrm.2020.194577"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INTERACTION WITH BLMP-1</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EEL0-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
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        <isoform>
            <id>G5EEL0-2</id>
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            <sequence type="described" ref="VSP_060758"/>
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        <property type="gene ID" value="WBGene00002261"/>
        <property type="gene designation" value="ldb-1"/>
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    <evidence type="ECO:0000305" key="1"/>
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        <source>
            <dbReference type="EMBL" id="AAB38367.1"/>
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    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
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    </evidence>
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    </evidence>
    <sequence length="578" mass="64791" checksum="59EA65AD22B41BCF" modified="2011-12-14" version="1"> </sequence>
</entry>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">Bristol N2</strain>
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        <property type="gene designation" value="gnrr-4"/>
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        </source>
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            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
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            <dbReference type="WormBase" id="C41G11.4c"/>
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    </evidence>
    <sequence length="511" mass="58679" checksum="423D797DF132DAA3" modified="2019-07-31" version="2">MSEATQQETQRVELSFSYTLELWMYGIAFCVGLPAFIFTVVRLARSRSSRQHLVLAARLFSYKISLSVADCIVLFIYAPTQFAWIHSYWWFGGDIGCRLFKFISTFGFHLTANMQVLVAADRLLITAKMNRVTRNIKKRQYNTRLSLAAAWILALICAGPQLILFRQKTTPQGYPQCISIWTEHRVDFYDRLELLEQYAYMQHELANKSPIYFFENGTLRYAKEDFPSEPGFTLEELHTNNRNWLYLERLYNVLHLATICVIPYAMELICYTLILYILKGASKGRFVSLSDIVKDIFCCCKRARQHESPIESNVTQESDNLMARVPSKTKRLQNIAPEGDMERRRAASVDVPMRIKNSSSLTVCIDENGSATAATRPEVTPQEQEPETRTQAFKRRVWNFLLDLFHNGSEGSVHFNGHKTELRLPNLTKGEARRQSAPASARSNTLWVVTVDTARRNARWKAFIMLSLNLVFWAPYCILAITSSVIISQYLTNFQFVNALVTFNAVSNIIL</sequence>
</entry>
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    <accession>H2KZA4</accession>
    <name>H2KZA4_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Zasp-like motif domain-containing protein</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">C46G7.4</name>
        <name evidence="3" type="ORF">CELE_C46G7.4</name>
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    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD67205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_068505.4"/>
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    <dbReference type="AGR" id="WB:WBGene00004112"/>
    <dbReference type="CTD" id="177369"/>
    <dbReference type="WormBase" id="C46G7.4c">
        <property type="protein sequence ID" value="CE37214"/>
        <property type="gene ID" value="WBGene00004112"/>
        <property type="gene designation" value="pqn-22"/>
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    <dbReference type="HOGENOM" id="CLU_277094_0_0_1"/>
    <dbReference type="OrthoDB" id="5919374at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="925" mass="103857" checksum="DB81010F578234D8" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZB3</accession>
    <name>H2KZB3_CAEEL</name>
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        <submittedName>
            <fullName evidence="8">TMEM (Human TransMEMbrane protein) homolog</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM39 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD67316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021072.1">
        <property type="nucleotide sequence ID" value="NM_001025901.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZB3"/>
    <dbReference type="PeptideAtlas" id="H2KZB3"/>
    <dbReference type="GeneID" id="172060"/>
    <dbReference type="AGR" id="WB:WBGene00017003"/>
    <dbReference type="CTD" id="172060"/>
    <dbReference type="WormBase" id="D1007.5b">
        <property type="protein sequence ID" value="CE33577"/>
        <property type="gene ID" value="WBGene00017003"/>
        <property type="gene designation" value="tmem-39"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862608at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017003">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZB3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019397">
        <property type="entry name" value="Uncharacterised_TMEM39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995:SF4">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10271">
        <property type="entry name" value="Tmp39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD67316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="D1007.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZB3"/>
        </source>
    </evidence>
    <sequence length="402" mass="46046" checksum="0E12A97C774B0573" modified="2012-03-21" version="1">MPPRRRVPAPPPQAPSVPASIPRASGVTLSVHPIWPDIQFTQGELFFECTLFLYSVLALFLQYLNIYKTLWWLPKSYWHYSLKFHLINPYFLSCVGLLLGWRVTVCFWKTITEVIATISANQSQFIQSSLMIVEYAAIKTPVMTLIITSFLFSFNRVCHDFPSRSVLWFLFPILFYAFIFRSEIIGWLGRFREQIGKWRRREIEFSDVCERLSESPPAQIDLESVLHMCSDSPAQIREEIQVLIDDLVLRVKKSIFAGVSTAFLSIMLPCIFVPFKTSQGIPQKILINEVWECQLAIVVGLTAFSLYVAYLSPLNYLDLLHRAAIHLGSWHQIEGPRIGHTGSMSSAPTPWSEFCLYNDGETVQMPDGRCYRAKSSNSIRTVAAHPESSRHNTFFCSENRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZB4</accession>
    <name>H2KZB4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">7TM_GPCR_Srx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_D1007.10</name>
        <name evidence="2 4" type="ORF">D1007.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD67321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021067.1">
        <property type="nucleotide sequence ID" value="NM_001025896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZB4"/>
    <dbReference type="GeneID" id="183889"/>
    <dbReference type="KEGG" id="cel:CELE_D1007.10"/>
    <dbReference type="AGR" id="WB:WBGene00017007"/>
    <dbReference type="CTD" id="183889"/>
    <dbReference type="WormBase" id="D1007.10a">
        <property type="protein sequence ID" value="CE09045"/>
        <property type="gene ID" value="WBGene00017007"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1099349_0_0_1"/>
    <dbReference type="OrthoDB" id="5797982at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017007">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZB4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD67321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="D1007.10a"/>
        </source>
    </evidence>
    <sequence length="253" mass="28752" checksum="54D38ED9AF177492" modified="2012-03-21" version="1">MHEKCANKPISTGGDCVASNTLCNVHFQNLVFPKHYIDFGEYVRDTFALRSRCTDLTLFACWYCFIAICHVATNTIFSRYVKTIHLVQRPLKTRIRGQAVFLVQFFTMNSIAALAAILFGAAGLSFMFIHFNYAAILFLESYRVFVRSLFVLGRLSVSTSTARMNDIEEQKHLSDEEITDLIVNSQKRIGKYLNFRNIYITSTVFVTFLLNILYAITGLLINRKMLAFGFAIGANQVIDDILNGREYGSTELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZB5</accession>
    <name>H2KZB5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">twk-17</name>
        <name evidence="18" type="ORF">C44E12.3</name>
        <name evidence="16" type="ORF">CELE_C44E12.3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024462.1">
        <property type="nucleotide sequence ID" value="NM_001029291.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZB5"/>
    <dbReference type="GeneID" id="181024"/>
    <dbReference type="KEGG" id="cel:CELE_C44E12.3"/>
    <dbReference type="AGR" id="WB:WBGene00006671"/>
    <dbReference type="CTD" id="181024"/>
    <dbReference type="WormBase" id="C44E12.3a">
        <property type="protein sequence ID" value="CE30900"/>
        <property type="gene ID" value="WBGene00006671"/>
        <property type="gene designation" value="twk-17"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006671">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZB5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF322">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="183"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="317"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD67333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="C44E12.3a"/>
        </source>
    </evidence>
    <sequence length="505" mass="57727" checksum="AF8C7B00626C9535" modified="2012-03-21" version="1">MGSLGVGRIFQVVQKPQLRLPFSDLAFVSSLPEHYLPQSLKENIGRVKWEEYNRREGIEDVPEQPIVVRVPIWRRILKLLKILLPHVGLNVLLLSYIAMGATVFIWLEADHELEGRKAKVKHVFDIYSQIMNETIALTNNQSDQATIVSRMRPLLESLSRAHEYDDKFTDTNQLWTGEQDGMTTRWTFAAATLYALTVITSTGYDHVTPATDPGRIFTVFFGLIGIPLMFITAADIGKFLSEIVIRTYAKLLAMWKMIANLVELVRTHLFDTDVDSIDSMELKKSKKRNASSLDDEECEDEEDRLQLPIASYFTLIIGYCCVGSLLFNTFEKGPVWSFIHGVFFSFNTITTIGLGNIRVQQHYYLALAVSYVIIGLAVITASLDLCSSTLKRTFTKLHYFGRKIRGARRGFANMSDDIREAMRIIAALKKTRPSKDRITLEDLKRFLEVQEHLLRQPYVPYNVHLLRWIEDNYAQYMDDVSGGKTPMSPSRLSHKMSSSDPMLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZB6</accession>
    <name>H2KZB6_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Ensconsin</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CELE_M01B12.4</name>
        <name evidence="3 5" type="ORF">M01B12.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD67365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="H2KZB6"/>
    <dbReference type="SMR" id="H2KZB6"/>
    <dbReference type="PeptideAtlas" id="H2KZB6"/>
    <dbReference type="AGR" id="WB:WBGene00019697"/>
    <dbReference type="WormBase" id="M01B12.4b">
        <property type="protein sequence ID" value="CE30554"/>
        <property type="gene ID" value="WBGene00019697"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_425294_0_0_1"/>
    <dbReference type="OrthoDB" id="5877833at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019697">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZB6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD67365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="M01B12.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZB6"/>
        </source>
    </evidence>
    <sequence length="644" mass="70454" checksum="B1AA0CA29ED33618" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZB8</accession>
    <name>H2KZB8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear Hormone Receptor family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">nhr-46</name>
        <name evidence="17" type="ORF">C45E5.6</name>
        <name evidence="15" type="ORF">CELE_C45E5.6</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD67373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_500858.2">
        <property type="nucleotide sequence ID" value="NM_068457.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZB8"/>
    <dbReference type="PeptideAtlas" id="H2KZB8"/>
    <dbReference type="GeneID" id="177350"/>
    <dbReference type="AGR" id="WB:WBGene00003636"/>
    <dbReference type="CTD" id="177350"/>
    <dbReference type="WormBase" id="C45E5.6a">
        <property type="protein sequence ID" value="CE08734"/>
        <property type="gene ID" value="WBGene00003636"/>
        <property type="gene designation" value="nhr-46"/>
    </dbReference>
    <dbReference type="OMA" id="MKGERCV"/>
    <dbReference type="OrthoDB" id="5814193at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003636">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZB8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052499">
        <property type="entry name" value="C.elegans_NHRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630:SF6">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="95"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="251"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD67373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C45E5.6a"/>
        </source>
    </evidence>
    <sequence length="528" mass="59074" checksum="38B6B1EB6D79CF03" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZC2</accession>
    <name>H2KZC2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">K+/Cl-Cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">kcc-2</name>
        <name evidence="18" type="ORF">CELE_H16O14.1</name>
        <name evidence="20" type="ORF">H16O14.1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD67532.1"/>
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</entry>
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    <sequence length="181" mass="19876" checksum="B3743B9B417827E6" modified="2012-03-21" version="1">MAQIIDFFAAFRGYYSDGSTFIQIISLGSHHNLSVHISERMLSESGIKLGNFLSATVSLAEHPKNFQLKRLNLQVTVEGNFAKVHGIEANLEKNADGILVFSTNNFASAKATNQGLEIGRYKITVQAVKPSEKDLFNGMKFFGTVEEKISGLTRRVASNNTNQVIGEGFRNMSISGKRTVS</sequence>
</entry>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2009" name="Cell" volume="138" first="314" last="327">
            <title>A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors.</title>
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                <person name="Grove C.A."/>
                <person name="De Masi F."/>
                <person name="Barrasa M.I."/>
                <person name="Newburger D.E."/>
                <person name="Alkema M.J."/>
                <person name="Bulyk M.L."/>
                <person name="Walhout A.J.M."/>
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            <title>MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.</title>
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                <person name="O'Rourke E.J."/>
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            <dbReference type="DOI" id="10.1038/ncb2741"/>
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        <scope>FUNCTION</scope>
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        <scope>TISSUE SPECIFICITY</scope>
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        <citation type="journal article" date="2013" name="Nat. Commun." volume="4" first="2267" last="2267">
            <title>The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.</title>
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                <person name="De Magalhaes Filho C.D."/>
                <person name="McQuary P.R."/>
                <person name="Chu C.C."/>
                <person name="Visvikis O."/>
                <person name="Chang J.T."/>
                <person name="Gelino S."/>
                <person name="Ong B."/>
                <person name="Davis A.E."/>
                <person name="Irazoqui J.E."/>
                <person name="Dillin A."/>
                <person name="Hansen M."/>
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            <dbReference type="DOI" id="10.1038/ncomms3267"/>
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        <scope>FUNCTION</scope>
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        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="1" key="5">
        <citation type="journal article" date="2014" name="Immunity" volume="40" first="896" last="909">
            <title>Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.</title>
            <authorList>
                <person name="Visvikis O."/>
                <person name="Ihuegbu N."/>
                <person name="Labed S.A."/>
                <person name="Luhachack L.G."/>
                <person name="Alves A.M."/>
                <person name="Wollenberg A.C."/>
                <person name="Stuart L.M."/>
                <person name="Stormo G.D."/>
                <person name="Irazoqui J.E."/>
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        <scope>FUNCTION</scope>
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        <citation type="journal article" date="2016" name="Cell Rep." volume="15" first="1728" last="1742">
            <title>An evolutionarily conserved PLC-PKD-TFEB pathway for host defense.</title>
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                <person name="Najibi M."/>
                <person name="Labed S.A."/>
                <person name="Visvikis O."/>
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        <scope>FUNCTION</scope>
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    <reference evidence="1" key="7">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10944" last="10944">
            <title>Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.</title>
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                <person name="Nakamura S."/>
                <person name="Karalay O."/>
                <person name="Jaeger P.S."/>
                <person name="Horikawa M."/>
                <person name="Klein C."/>
                <person name="Nakamura K."/>
                <person name="Latza C."/>
                <person name="Templer S.E."/>
                <person name="Dieterich C."/>
                <person name="Antebi A."/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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        <citation type="journal article" date="2017" name="Autophagy" volume="13" first="371" last="385">
            <title>HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.</title>
            <authorList>
                <person name="Chen H.D."/>
                <person name="Kao C.Y."/>
                <person name="Liu B.Y."/>
                <person name="Huang S.W."/>
                <person name="Kuo C.J."/>
                <person name="Ruan J.W."/>
                <person name="Lin Y.H."/>
                <person name="Huang C.R."/>
                <person name="Chen Y.H."/>
                <person name="Wang H.D."/>
                <person name="Aroian R.V."/>
                <person name="Chen C.S."/>
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            <dbReference type="PubMed" id="27875098"/>
            <dbReference type="DOI" id="10.1080/15548627.2016.1256933"/>
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        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="14337" last="14337">
            <title>Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.</title>
            <authorList>
                <person name="Kumsta C."/>
                <person name="Chang J.T."/>
                <person name="Schmalz J."/>
                <person name="Hansen M."/>
            </authorList>
            <dbReference type="PubMed" id="28198373"/>
            <dbReference type="DOI" id="10.1038/ncomms14337"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.</title>
            <authorList>
                <person name="Blazie S.M."/>
                <person name="Takayanagi-Kiya S."/>
                <person name="McCulloch K.A."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="34323215"/>
            <dbReference type="DOI" id="10.7554/elife.68336"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
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        <event type="alternative splicing"/>
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        <isoform>
            <id>H2KZZ2-10</id>
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    <evidence type="ECO:0000312" key="9">
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    <evidence type="ECO:0000312" key="10">
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    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="W02C12.3j"/>
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    </evidence>
    <sequence length="498" mass="54391" checksum="A71EF26EE9181E9D" modified="2012-03-21" version="1">MADDDDRVDISNETLASLVGRPMSSSGNRIRATPSRRRLVSAPTNPRWSPSADDRRLFSYVSSMRSDSNSSSKSPSPPSAKMSKRPNGPYSVRKYQPRGSPPSDGSDKIHRFGESPTPGGVGGVFGTELDDLIIDELMGMEDDQRMRPGATRPMTIGGEKTMSMARPIPGASSRAGSGHSGSPITIPNAMSNNFRQVVSSSAPTSSIDIEKMIGAVSNGGGNSGGDNDPEDYYRDRRKKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQKDREQAMKTQQQQKSLESTAHKYADRVKELEEMLARQGVQVPPSHLPPIPKVIERPIKQEIDESPPNHTPTGSFVSSSGFLSEVTNNTAAMQITSPNDSRPNNFMNNSAPSDSFFSVGSASPPDYRTSSGTASWKLPGSNAFSDLMMDDLNPMMNGDPLISSAGAHPSPHFHSSQMSPDIHWDASGFSPDPINTQQSNSGHYHMDFS</sequence>
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    <accession>H2KZZ2-4</accession>
    <name>HLH30_CAEEL</name>
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        <recommendedName>
            <fullName evidence="1">Isoform d of Helix-loop-helix protein 30</fullName>
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        <name evidence="5" type="primary">hlh-30</name>
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            <taxon>Rhabditina</taxon>
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            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2009" name="Cell" volume="138" first="314" last="327">
            <title>A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors.</title>
            <authorList>
                <person name="Grove C.A."/>
                <person name="De Masi F."/>
                <person name="Barrasa M.I."/>
                <person name="Newburger D.E."/>
                <person name="Alkema M.J."/>
                <person name="Bulyk M.L."/>
                <person name="Walhout A.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="19632181"/>
            <dbReference type="DOI" id="10.1016/j.cell.2009.04.058"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Nat. Cell Biol." volume="15" first="668" last="676">
            <title>MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.</title>
            <authorList>
                <person name="O'Rourke E.J."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="23604316"/>
            <dbReference type="DOI" id="10.1038/ncb2741"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2013" name="Nat. Commun." volume="4" first="2267" last="2267">
            <title>The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lapierre L.R."/>
                <person name="De Magalhaes Filho C.D."/>
                <person name="McQuary P.R."/>
                <person name="Chu C.C."/>
                <person name="Visvikis O."/>
                <person name="Chang J.T."/>
                <person name="Gelino S."/>
                <person name="Ong B."/>
                <person name="Davis A.E."/>
                <person name="Irazoqui J.E."/>
                <person name="Dillin A."/>
                <person name="Hansen M."/>
            </authorList>
            <dbReference type="PubMed" id="23925298"/>
            <dbReference type="DOI" id="10.1038/ncomms3267"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2014" name="Immunity" volume="40" first="896" last="909">
            <title>Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.</title>
            <authorList>
                <person name="Visvikis O."/>
                <person name="Ihuegbu N."/>
                <person name="Labed S.A."/>
                <person name="Luhachack L.G."/>
                <person name="Alves A.M."/>
                <person name="Wollenberg A.C."/>
                <person name="Stuart L.M."/>
                <person name="Stormo G.D."/>
                <person name="Irazoqui J.E."/>
            </authorList>
            <dbReference type="PubMed" id="24882217"/>
            <dbReference type="DOI" id="10.1016/j.immuni.2014.05.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2016" name="Cell Rep." volume="15" first="1728" last="1742">
            <title>An evolutionarily conserved PLC-PKD-TFEB pathway for host defense.</title>
            <authorList>
                <person name="Najibi M."/>
                <person name="Labed S.A."/>
                <person name="Visvikis O."/>
                <person name="Irazoqui J.E."/>
            </authorList>
            <dbReference type="PubMed" id="27184844"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.04.052"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="1" key="7">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10944" last="10944">
            <title>Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.</title>
            <authorList>
                <person name="Nakamura S."/>
                <person name="Karalay O."/>
                <person name="Jaeger P.S."/>
                <person name="Horikawa M."/>
                <person name="Klein C."/>
                <person name="Nakamura K."/>
                <person name="Latza C."/>
                <person name="Templer S.E."/>
                <person name="Dieterich C."/>
                <person name="Antebi A."/>
            </authorList>
            <dbReference type="PubMed" id="27001890"/>
            <dbReference type="DOI" id="10.1038/ncomms10944"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="8">
        <citation type="journal article" date="2017" name="Autophagy" volume="13" first="371" last="385">
            <title>HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.</title>
            <authorList>
                <person name="Chen H.D."/>
                <person name="Kao C.Y."/>
                <person name="Liu B.Y."/>
                <person name="Huang S.W."/>
                <person name="Kuo C.J."/>
                <person name="Ruan J.W."/>
                <person name="Lin Y.H."/>
                <person name="Huang C.R."/>
                <person name="Chen Y.H."/>
                <person name="Wang H.D."/>
                <person name="Aroian R.V."/>
                <person name="Chen C.S."/>
            </authorList>
            <dbReference type="PubMed" id="27875098"/>
            <dbReference type="DOI" id="10.1080/15548627.2016.1256933"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="14337" last="14337">
            <title>Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.</title>
            <authorList>
                <person name="Kumsta C."/>
                <person name="Chang J.T."/>
                <person name="Schmalz J."/>
                <person name="Hansen M."/>
            </authorList>
            <dbReference type="PubMed" id="28198373"/>
            <dbReference type="DOI" id="10.1038/ncomms14337"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.</title>
            <authorList>
                <person name="Blazie S.M."/>
                <person name="Takayanagi-Kiya S."/>
                <person name="McCulloch K.A."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="34323215"/>
            <dbReference type="DOI" id="10.7554/elife.68336"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KZZ2-7</id>
            <name evidence="9">g</name>
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        <isoform>
            <id>H2KZZ2-8</id>
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            <sequence type="described" ref="VSP_060891"/>
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        <isoform>
            <id>H2KZZ2-6</id>
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        </isoform>
        <isoform>
            <id>H2KZZ2-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_060894 VSP_060895"/>
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        <isoform>
            <id>H2KZZ2-3</id>
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            <sequence type="described" ref="VSP_060895"/>
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        <isoform>
            <id>H2KZZ2-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_060894"/>
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        <isoform>
            <id>H2KZZ2-1</id>
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        <isoform>
            <id>H2KZZ2-2</id>
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            <sequence type="described" ref="VSP_060892"/>
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        <isoform>
            <id>H2KZZ2-4</id>
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            <sequence type="described" ref="VSP_060893"/>
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        <isoform>
            <id>H2KZZ2-5</id>
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    <evidence type="ECO:0000312" key="4">
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="W02C12.3j"/>
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    </evidence>
    <sequence length="464" mass="50387" checksum="90B14488905F963E" modified="2012-03-21" version="1">MEQRRETGNLIPIAQRSMGSTSTPFGSAPTQSYFGGGSSGAALSSPRKMQQTHQMLFGNIQPPRGSPPSDGSDKIHRFGESPTPGGVGGVFGTELDDLIIDELMGMEDDQRMRPGATRPMTIGGEKTMSMARPIPGASSRAGSGHSGSPITIPNAMSNNFRQVVSSSAPTSSIDIEKMIGAVSNGGGNSGGDNDPEDYYRDRRKKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQKDREQAMKTQQQQKSLESTAHKYADRVKELEEMLARQGVQVPPSHLPPIPKVIERPIKQEIDESPPNHTPTGSFVSSSGFLSEVTNNTAAMQITSPNDSRPNNFMNNSAPSDSFFSVGSASPPDYRTSSGTASWKLPGSNAFSDLMMDDLNPMMNGDPLISSAGAHPSPHFHSSQMSPDIHWDASGFSPDPINTQQSNSGHYHMDFS</sequence>
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        <recommendedName>
            <fullName evidence="1">Isoform e of Helix-loop-helix protein 30</fullName>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
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                <person name="Chang J.T."/>
                <person name="Gelino S."/>
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                <person name="Ruan J.W."/>
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            <sequence type="described" ref="VSP_060894 VSP_060895"/>
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    </comment>
    <dbReference type="RefSeq" id="NP_001023414.1">
        <property type="nucleotide sequence ID" value="NM_001028243.3"/>
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    <dbReference type="WormBase" id="W02C12.3f">
        <property type="protein sequence ID" value="CE33715"/>
        <property type="gene ID" value="WBGene00020930"/>
        <property type="gene designation" value="hlh-30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="W02C12.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="W02C12.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="W02C12.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="W02C12.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="W02C12.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="W02C12.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="W02C12.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="W02C12.3h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="W02C12.3i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="W02C12.3j"/>
        </source>
    </evidence>
    <sequence length="473" mass="51521" checksum="4C263B4F5F753645" modified="2012-03-21" version="1">MADDDDRVDISNETLASLVGRPMSSSGNRIRATPSRRRLVSAPTNPRWSPSADDRRLFSYVSSMRSDSNSSSKSPSPPSAKMSKRPNGPYSVRKYQPRGSPPSDGSDKIHRFGESPTPGGVGGVFGTEMTIGGEKTMSMARPIPGASSRAGSGHSGSPITIPNAMSNNFRQVVSSSAPTSSIDIEKMIGAVSNGGGNSGGDNDPEDYYRDRRKKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQKDREQAMKTQQQQKSLESTAHKYADRVKELEEMLARQGVQVPPSHLPPIPKVIERPIKQEIDESPPNHTPTGSFVSSSGFLSEVTNNTAAMQITSPNDSRPNNFMNNSAPSDSFFSVGSASPPDYRTSSGTASWKLPGSNAFSDLMMDDLNPMMNGDPLISSAGAHPSPHFHSSQMSPDIHWDASGFSPDPINTQQSNSGHYHMDFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-02-10" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZZ2-7</accession>
    <name>HLH30_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform g of Helix-loop-helix protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hlh-30</name>
        <name evidence="5" type="ORF">W02C12.3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2009" name="Cell" volume="138" first="314" last="327">
            <title>A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors.</title>
            <authorList>
                <person name="Grove C.A."/>
                <person name="De Masi F."/>
                <person name="Barrasa M.I."/>
                <person name="Newburger D.E."/>
                <person name="Alkema M.J."/>
                <person name="Bulyk M.L."/>
                <person name="Walhout A.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="19632181"/>
            <dbReference type="DOI" id="10.1016/j.cell.2009.04.058"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Nat. Cell Biol." volume="15" first="668" last="676">
            <title>MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.</title>
            <authorList>
                <person name="O'Rourke E.J."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="23604316"/>
            <dbReference type="DOI" id="10.1038/ncb2741"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2013" name="Nat. Commun." volume="4" first="2267" last="2267">
            <title>The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lapierre L.R."/>
                <person name="De Magalhaes Filho C.D."/>
                <person name="McQuary P.R."/>
                <person name="Chu C.C."/>
                <person name="Visvikis O."/>
                <person name="Chang J.T."/>
                <person name="Gelino S."/>
                <person name="Ong B."/>
                <person name="Davis A.E."/>
                <person name="Irazoqui J.E."/>
                <person name="Dillin A."/>
                <person name="Hansen M."/>
            </authorList>
            <dbReference type="PubMed" id="23925298"/>
            <dbReference type="DOI" id="10.1038/ncomms3267"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2014" name="Immunity" volume="40" first="896" last="909">
            <title>Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.</title>
            <authorList>
                <person name="Visvikis O."/>
                <person name="Ihuegbu N."/>
                <person name="Labed S.A."/>
                <person name="Luhachack L.G."/>
                <person name="Alves A.M."/>
                <person name="Wollenberg A.C."/>
                <person name="Stuart L.M."/>
                <person name="Stormo G.D."/>
                <person name="Irazoqui J.E."/>
            </authorList>
            <dbReference type="PubMed" id="24882217"/>
            <dbReference type="DOI" id="10.1016/j.immuni.2014.05.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2016" name="Cell Rep." volume="15" first="1728" last="1742">
            <title>An evolutionarily conserved PLC-PKD-TFEB pathway for host defense.</title>
            <authorList>
                <person name="Najibi M."/>
                <person name="Labed S.A."/>
                <person name="Visvikis O."/>
                <person name="Irazoqui J.E."/>
            </authorList>
            <dbReference type="PubMed" id="27184844"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.04.052"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="1" key="7">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10944" last="10944">
            <title>Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.</title>
            <authorList>
                <person name="Nakamura S."/>
                <person name="Karalay O."/>
                <person name="Jaeger P.S."/>
                <person name="Horikawa M."/>
                <person name="Klein C."/>
                <person name="Nakamura K."/>
                <person name="Latza C."/>
                <person name="Templer S.E."/>
                <person name="Dieterich C."/>
                <person name="Antebi A."/>
            </authorList>
            <dbReference type="PubMed" id="27001890"/>
            <dbReference type="DOI" id="10.1038/ncomms10944"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="8">
        <citation type="journal article" date="2017" name="Autophagy" volume="13" first="371" last="385">
            <title>HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.</title>
            <authorList>
                <person name="Chen H.D."/>
                <person name="Kao C.Y."/>
                <person name="Liu B.Y."/>
                <person name="Huang S.W."/>
                <person name="Kuo C.J."/>
                <person name="Ruan J.W."/>
                <person name="Lin Y.H."/>
                <person name="Huang C.R."/>
                <person name="Chen Y.H."/>
                <person name="Wang H.D."/>
                <person name="Aroian R.V."/>
                <person name="Chen C.S."/>
            </authorList>
            <dbReference type="PubMed" id="27875098"/>
            <dbReference type="DOI" id="10.1080/15548627.2016.1256933"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="14337" last="14337">
            <title>Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.</title>
            <authorList>
                <person name="Kumsta C."/>
                <person name="Chang J.T."/>
                <person name="Schmalz J."/>
                <person name="Hansen M."/>
            </authorList>
            <dbReference type="PubMed" id="28198373"/>
            <dbReference type="DOI" id="10.1038/ncomms14337"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.</title>
            <authorList>
                <person name="Blazie S.M."/>
                <person name="Takayanagi-Kiya S."/>
                <person name="McCulloch K.A."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="34323215"/>
            <dbReference type="DOI" id="10.7554/elife.68336"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KZZ2-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060895 VSP_060893"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060895"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060892"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_060894"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_060891"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-1</id>
            <name evidence="5">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_060897 VSP_060896 VSP_060892"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-6</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_060892 VSP_060895"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060893"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_060894 VSP_060895"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001360026.1">
        <property type="nucleotide sequence ID" value="NM_001372787.4"/>
    </dbReference>
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        <property type="protein sequence ID" value="CE33716"/>
        <property type="gene ID" value="WBGene00020930"/>
        <property type="gene designation" value="hlh-30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="W02C12.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="W02C12.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="W02C12.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="W02C12.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="W02C12.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="W02C12.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="W02C12.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="W02C12.3h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="W02C12.3i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="W02C12.3j"/>
        </source>
    </evidence>
    <sequence length="437" mass="47923" checksum="61CC89D9A9BD02D0" modified="2012-03-21" version="1">MADDDDRVDISNETLASLVGRPMSSSGNRIRATPSRRRLVSAPTNPRWSPSADDRRLFSYVSSMRSDSNSSSKSPSPPSAKMSKRPNGPYSVRKYQPRGSPPSDGSDKIHRFGESPTPGGVGGVFGTELDDLIIDELMGMEDDQRMRPGATRPMTIGGEKTMSMARPIPGASSRAGSGHSGSPITIPNAMSNNFRQVVSSSAPTSSIDIEKMIGAVSNGGGNSGGDNDPEDYYRDRRKKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQKDREQAMKTQQQQKSLESTAHKYADRVKELEEMLARQGVQVPPSHLPPIPKVIERPIKQEIDESPPNHTPTGSFVSSSGFLSEVTNNTAAMQITSPNDSRPNNFMNNSAPSDSFFSVGSASPPDYSEPISQSFHARGFLLEPICEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-02-10" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZZ2-8</accession>
    <name>HLH30_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform h of Helix-loop-helix protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hlh-30</name>
        <name evidence="5" type="ORF">W02C12.3</name>
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    <organism>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2009" name="Cell" volume="138" first="314" last="327">
            <title>A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors.</title>
            <authorList>
                <person name="Grove C.A."/>
                <person name="De Masi F."/>
                <person name="Barrasa M.I."/>
                <person name="Newburger D.E."/>
                <person name="Alkema M.J."/>
                <person name="Bulyk M.L."/>
                <person name="Walhout A.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="19632181"/>
            <dbReference type="DOI" id="10.1016/j.cell.2009.04.058"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Nat. Cell Biol." volume="15" first="668" last="676">
            <title>MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.</title>
            <authorList>
                <person name="O'Rourke E.J."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="23604316"/>
            <dbReference type="DOI" id="10.1038/ncb2741"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2013" name="Nat. Commun." volume="4" first="2267" last="2267">
            <title>The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lapierre L.R."/>
                <person name="De Magalhaes Filho C.D."/>
                <person name="McQuary P.R."/>
                <person name="Chu C.C."/>
                <person name="Visvikis O."/>
                <person name="Chang J.T."/>
                <person name="Gelino S."/>
                <person name="Ong B."/>
                <person name="Davis A.E."/>
                <person name="Irazoqui J.E."/>
                <person name="Dillin A."/>
                <person name="Hansen M."/>
            </authorList>
            <dbReference type="PubMed" id="23925298"/>
            <dbReference type="DOI" id="10.1038/ncomms3267"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2014" name="Immunity" volume="40" first="896" last="909">
            <title>Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.</title>
            <authorList>
                <person name="Visvikis O."/>
                <person name="Ihuegbu N."/>
                <person name="Labed S.A."/>
                <person name="Luhachack L.G."/>
                <person name="Alves A.M."/>
                <person name="Wollenberg A.C."/>
                <person name="Stuart L.M."/>
                <person name="Stormo G.D."/>
                <person name="Irazoqui J.E."/>
            </authorList>
            <dbReference type="PubMed" id="24882217"/>
            <dbReference type="DOI" id="10.1016/j.immuni.2014.05.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2016" name="Cell Rep." volume="15" first="1728" last="1742">
            <title>An evolutionarily conserved PLC-PKD-TFEB pathway for host defense.</title>
            <authorList>
                <person name="Najibi M."/>
                <person name="Labed S.A."/>
                <person name="Visvikis O."/>
                <person name="Irazoqui J.E."/>
            </authorList>
            <dbReference type="PubMed" id="27184844"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.04.052"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="1" key="7">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10944" last="10944">
            <title>Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.</title>
            <authorList>
                <person name="Nakamura S."/>
                <person name="Karalay O."/>
                <person name="Jaeger P.S."/>
                <person name="Horikawa M."/>
                <person name="Klein C."/>
                <person name="Nakamura K."/>
                <person name="Latza C."/>
                <person name="Templer S.E."/>
                <person name="Dieterich C."/>
                <person name="Antebi A."/>
            </authorList>
            <dbReference type="PubMed" id="27001890"/>
            <dbReference type="DOI" id="10.1038/ncomms10944"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="8">
        <citation type="journal article" date="2017" name="Autophagy" volume="13" first="371" last="385">
            <title>HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.</title>
            <authorList>
                <person name="Chen H.D."/>
                <person name="Kao C.Y."/>
                <person name="Liu B.Y."/>
                <person name="Huang S.W."/>
                <person name="Kuo C.J."/>
                <person name="Ruan J.W."/>
                <person name="Lin Y.H."/>
                <person name="Huang C.R."/>
                <person name="Chen Y.H."/>
                <person name="Wang H.D."/>
                <person name="Aroian R.V."/>
                <person name="Chen C.S."/>
            </authorList>
            <dbReference type="PubMed" id="27875098"/>
            <dbReference type="DOI" id="10.1080/15548627.2016.1256933"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="14337" last="14337">
            <title>Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.</title>
            <authorList>
                <person name="Kumsta C."/>
                <person name="Chang J.T."/>
                <person name="Schmalz J."/>
                <person name="Hansen M."/>
            </authorList>
            <dbReference type="PubMed" id="28198373"/>
            <dbReference type="DOI" id="10.1038/ncomms14337"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.</title>
            <authorList>
                <person name="Blazie S.M."/>
                <person name="Takayanagi-Kiya S."/>
                <person name="McCulloch K.A."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="34323215"/>
            <dbReference type="DOI" id="10.7554/elife.68336"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KZZ2-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_060891"/>
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        <isoform>
            <id>H2KZZ2-10</id>
            <name evidence="12">j</name>
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        </isoform>
        <isoform>
            <id>H2KZZ2-1</id>
            <name evidence="5">c</name>
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        </isoform>
        <isoform>
            <id>H2KZZ2-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060892"/>
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        <isoform>
            <id>H2KZZ2-9</id>
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        <isoform>
            <id>H2KZZ2-3</id>
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            <sequence type="described" ref="VSP_060895"/>
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        <isoform>
            <id>H2KZZ2-4</id>
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        <isoform>
            <id>H2KZZ2-6</id>
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        <isoform>
            <id>H2KZZ2-5</id>
            <name evidence="7">e</name>
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        <isoform>
            <id>H2KZZ2-7</id>
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        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379927.1">
        <property type="nucleotide sequence ID" value="NM_001392290.1"/>
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        <property type="protein sequence ID" value="CE37725"/>
        <property type="gene ID" value="WBGene00020930"/>
        <property type="gene designation" value="hlh-30"/>
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        <property type="component" value="Chromosome IV"/>
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    <evidence type="ECO:0000305" key="1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="W02C12.3a"/>
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    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="W02C12.3b"/>
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    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="W02C12.3c"/>
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    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="W02C12.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="W02C12.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="W02C12.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="W02C12.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="W02C12.3h"/>
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    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="W02C12.3i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="W02C12.3j"/>
        </source>
    </evidence>
    <sequence length="361" mass="39585" checksum="31C8CDE45E09281F" modified="2012-03-21" version="1">MGMEDDQRMRPGATRPMTIGGEKTMSMARPIPGASSRAGSGHSGSPITIPNAMSNNFRQVVSSSAPTSSIDIEKMIGAVSNGGGNSGGDNDPEDYYRDRRKKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQKDREQAMKTQQQQKSLESTAHKYADRVKELEEMLARQGVQVPPSHLPPIPKVIERPIKQEIDESPPNHTPTGSFVSSSGFLSEVTNNTAAMQITSPNDSRPNNFMNNSAPSDSFFSVGSASPPDYRTSSGTASWKLPGSNAFSDLMMDDLNPMMNGDPLISSAGAHPSPHFHSSQMSPDIHWDASGFSPDPINTQQSNSGHYHMDFS</sequence>
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<entry dataset="Swiss-Prot" created="2021-02-10" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZZ2-9</accession>
    <name>HLH30_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform i of Helix-loop-helix protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hlh-30</name>
        <name evidence="5" type="ORF">W02C12.3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2009" name="Cell" volume="138" first="314" last="327">
            <title>A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors.</title>
            <authorList>
                <person name="Grove C.A."/>
                <person name="De Masi F."/>
                <person name="Barrasa M.I."/>
                <person name="Newburger D.E."/>
                <person name="Alkema M.J."/>
                <person name="Bulyk M.L."/>
                <person name="Walhout A.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="19632181"/>
            <dbReference type="DOI" id="10.1016/j.cell.2009.04.058"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Nat. Cell Biol." volume="15" first="668" last="676">
            <title>MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.</title>
            <authorList>
                <person name="O'Rourke E.J."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="23604316"/>
            <dbReference type="DOI" id="10.1038/ncb2741"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2013" name="Nat. Commun." volume="4" first="2267" last="2267">
            <title>The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lapierre L.R."/>
                <person name="De Magalhaes Filho C.D."/>
                <person name="McQuary P.R."/>
                <person name="Chu C.C."/>
                <person name="Visvikis O."/>
                <person name="Chang J.T."/>
                <person name="Gelino S."/>
                <person name="Ong B."/>
                <person name="Davis A.E."/>
                <person name="Irazoqui J.E."/>
                <person name="Dillin A."/>
                <person name="Hansen M."/>
            </authorList>
            <dbReference type="PubMed" id="23925298"/>
            <dbReference type="DOI" id="10.1038/ncomms3267"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2014" name="Immunity" volume="40" first="896" last="909">
            <title>Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.</title>
            <authorList>
                <person name="Visvikis O."/>
                <person name="Ihuegbu N."/>
                <person name="Labed S.A."/>
                <person name="Luhachack L.G."/>
                <person name="Alves A.M."/>
                <person name="Wollenberg A.C."/>
                <person name="Stuart L.M."/>
                <person name="Stormo G.D."/>
                <person name="Irazoqui J.E."/>
            </authorList>
            <dbReference type="PubMed" id="24882217"/>
            <dbReference type="DOI" id="10.1016/j.immuni.2014.05.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2016" name="Cell Rep." volume="15" first="1728" last="1742">
            <title>An evolutionarily conserved PLC-PKD-TFEB pathway for host defense.</title>
            <authorList>
                <person name="Najibi M."/>
                <person name="Labed S.A."/>
                <person name="Visvikis O."/>
                <person name="Irazoqui J.E."/>
            </authorList>
            <dbReference type="PubMed" id="27184844"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.04.052"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="1" key="7">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10944" last="10944">
            <title>Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.</title>
            <authorList>
                <person name="Nakamura S."/>
                <person name="Karalay O."/>
                <person name="Jaeger P.S."/>
                <person name="Horikawa M."/>
                <person name="Klein C."/>
                <person name="Nakamura K."/>
                <person name="Latza C."/>
                <person name="Templer S.E."/>
                <person name="Dieterich C."/>
                <person name="Antebi A."/>
            </authorList>
            <dbReference type="PubMed" id="27001890"/>
            <dbReference type="DOI" id="10.1038/ncomms10944"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="8">
        <citation type="journal article" date="2017" name="Autophagy" volume="13" first="371" last="385">
            <title>HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.</title>
            <authorList>
                <person name="Chen H.D."/>
                <person name="Kao C.Y."/>
                <person name="Liu B.Y."/>
                <person name="Huang S.W."/>
                <person name="Kuo C.J."/>
                <person name="Ruan J.W."/>
                <person name="Lin Y.H."/>
                <person name="Huang C.R."/>
                <person name="Chen Y.H."/>
                <person name="Wang H.D."/>
                <person name="Aroian R.V."/>
                <person name="Chen C.S."/>
            </authorList>
            <dbReference type="PubMed" id="27875098"/>
            <dbReference type="DOI" id="10.1080/15548627.2016.1256933"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="14337" last="14337">
            <title>Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.</title>
            <authorList>
                <person name="Kumsta C."/>
                <person name="Chang J.T."/>
                <person name="Schmalz J."/>
                <person name="Hansen M."/>
            </authorList>
            <dbReference type="PubMed" id="28198373"/>
            <dbReference type="DOI" id="10.1038/ncomms14337"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.</title>
            <authorList>
                <person name="Blazie S.M."/>
                <person name="Takayanagi-Kiya S."/>
                <person name="McCulloch K.A."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="34323215"/>
            <dbReference type="DOI" id="10.7554/elife.68336"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KZZ2-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_060894 VSP_060895"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_060894"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060893"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-6</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_060895 VSP_060892"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_060892 VSP_060897 VSP_060896"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060895 VSP_060893"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_060891"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-1</id>
            <name evidence="5">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060895"/>
        </isoform>
        <isoform>
            <id>H2KZZ2-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060892"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001368701.1">
        <property type="nucleotide sequence ID" value="NM_001380173.1"/>
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    <dbReference type="WormBase" id="W02C12.3i">
        <property type="protein sequence ID" value="CE52661"/>
        <property type="gene ID" value="WBGene00020930"/>
        <property type="gene designation" value="hlh-30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="W02C12.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="W02C12.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="W02C12.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="W02C12.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="W02C12.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="W02C12.3f"/>
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    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="W02C12.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="W02C12.3h"/>
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    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="W02C12.3i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="W02C12.3j"/>
        </source>
    </evidence>
    <sequence length="473" mass="51386" checksum="838E1F2AC2AE3BDA" modified="2012-03-21" version="1">MAASWLPNQMEQRRETGNLIPIAQRSMGSTSTPFGSAPTQSYFGGGSSGAALSSPRKMQQTHQMLFGNIQPPRGSPPSDGSDKIHRFGESPTPGGVGGVFGTELDDLIIDELMGMEDDQRMRPGATRPMTIGGEKTMSMARPIPGASSRAGSGHSGSPITIPNAMSNNFRQVVSSSAPTSSIDIEKMIGAVSNGGGNSGGDNDPEDYYRDRRKKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQKDREQAMKTQQQQKSLESTAHKYADRVKELEEMLARQGVQVPPSHLPPIPKVIERPIKQEIDESPPNHTPTGSFVSSSGFLSEVTNNTAAMQITSPNDSRPNNFMNNSAPSDSFFSVGSASPPDYRTSSGTASWKLPGSNAFSDLMMDDLNPMMNGDPLISSAGAHPSPHFHSSQMSPDIHWDASGFSPDPINTQQSNSGHYHMDFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-02-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="5">Isoform b of Tensin homolog</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
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        <alternativeName>
            <fullName evidence="3">C1 domain-containing phosphatase and tensin homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Suppressor of vhp-1 deletion lethality protein svh-6</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="primary">tns-1</name>
        <name evidence="2" type="synonym">svh-6</name>
        <name evidence="5" type="synonym">tag-163</name>
        <name evidence="5" type="ORF">M01E11.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2019" name="J. Neurosci." volume="39" first="5662" last="5672">
            <title>C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Shimizu T."/>
                <person name="Asai K."/>
                <person name="Sakai Y."/>
                <person name="Pastuhov S.I."/>
                <person name="Hanafusa H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="31109965"/>
            <dbReference type="DOI" id="10.1523/jneurosci.2059-18.2019"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SVH-2 AND PAT-3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF 38-MET--SER-335; ARG-1108 AND 1192-ALA--SER-1354</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2L045-2</id>
            <name evidence="6">b</name>
            <name evidence="2">tns-1s</name>
            <sequence type="described" ref="VSP_060492"/>
        </isoform>
        <isoform>
            <id>H2L045-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_060502"/>
        </isoform>
        <isoform>
            <id>H2L045-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2L045-7</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_060500"/>
        </isoform>
        <isoform>
            <id>H2L045-8</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_060499"/>
        </isoform>
        <isoform>
            <id>H2L045-6</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_060501"/>
        </isoform>
        <isoform>
            <id>H2L045-5</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_060503"/>
        </isoform>
        <isoform>
            <id>H2L045-4</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_060504 VSP_060505 VSP_060502"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="RefSeq" id="NP_491638.1">
        <property type="nucleotide sequence ID" value="NM_059237.7"/>
    </dbReference>
    <dbReference type="WormBase" id="M01E11.7b">
        <property type="protein sequence ID" value="CE12302"/>
        <property type="gene ID" value="WBGene00006508"/>
        <property type="gene designation" value="tns-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q63HR2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="31109965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="M01E11.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="M01E11.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="M01E11.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="M01E11.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="M01E11.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="M01E11.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="M01E11.7g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="M01E11.7h"/>
        </source>
    </evidence>
    <sequence length="417" mass="45350" checksum="08085DDC69289CBB" modified="2016-02-17" version="2">MSDTATTSTTVVIHLKRSNHDDASASATTAQLQQRSRYCDVSLASSEESSDLSDAEEKDDLIRRTITSSSKDTMEEGDDDDEEEFDDVVMEEDVGGGTDANEQFSRVIQRQISGAGGGILKKSNGKDTSEIIHHHPLFVKDTSKYWYKPTISREQAINMLRDKPPGTFVVRDSNSFPGAFGLALKVSTPPPGVNPGDGSELVRHFLIEPSPKGVKLKGCNNEPVFGSLSALVYQHSITALALPTKLVLPDFDPAATPEHLSATQALLEQGAACNVVYVGSVDVESLTGNECVKRSIATCSQRAINGDSRAVSVHFKVSSQGVTLTDNTRKVFFRRHFNVQSVIFAGMDPIERRFENTRALGFHDGCIAQARLFAFVARIPSSSENACHVFAELEPEQPGSAVVNFINKVMLAQKNRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-02-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>H2L045-3</accession>
    <name>TENSH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform c of Tensin homolog</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">C1 domain-containing phosphatase and tensin homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Suppressor of vhp-1 deletion lethality protein svh-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tns-1</name>
        <name evidence="2" type="synonym">svh-6</name>
        <name evidence="5" type="synonym">tag-163</name>
        <name evidence="5" type="ORF">M01E11.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2019" name="J. Neurosci." volume="39" first="5662" last="5672">
            <title>C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Shimizu T."/>
                <person name="Asai K."/>
                <person name="Sakai Y."/>
                <person name="Pastuhov S.I."/>
                <person name="Hanafusa H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="31109965"/>
            <dbReference type="DOI" id="10.1523/jneurosci.2059-18.2019"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SVH-2 AND PAT-3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF 38-MET--SER-335; ARG-1108 AND 1192-ALA--SER-1354</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2L045-5</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_060503"/>
        </isoform>
        <isoform>
            <id>H2L045-8</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_060499"/>
        </isoform>
        <isoform>
            <id>H2L045-4</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_060505 VSP_060502 VSP_060504"/>
        </isoform>
        <isoform>
            <id>H2L045-6</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_060501"/>
        </isoform>
        <isoform>
            <id>H2L045-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2L045-2</id>
            <name evidence="6">b</name>
            <name evidence="2">tns-1s</name>
            <sequence type="described" ref="VSP_060492"/>
        </isoform>
        <isoform>
            <id>H2L045-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_060502"/>
        </isoform>
        <isoform>
            <id>H2L045-7</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_060500"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001379959.1">
        <property type="nucleotide sequence ID" value="NM_001392327.1"/>
    </dbReference>
    <dbReference type="WormBase" id="M01E11.7c">
        <property type="protein sequence ID" value="CE28613"/>
        <property type="gene ID" value="WBGene00006508"/>
        <property type="gene designation" value="tns-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q63HR2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="31109965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="M01E11.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="M01E11.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="M01E11.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="M01E11.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="M01E11.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="M01E11.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="M01E11.7g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="M01E11.7h"/>
        </source>
    </evidence>
    <sequence length="949" mass="105551" checksum="9EAF9F570C0F3000" modified="2016-02-17" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-02-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>H2L045-4</accession>
    <name>TENSH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform d of Tensin homolog</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">C1 domain-containing phosphatase and tensin homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Suppressor of vhp-1 deletion lethality protein svh-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tns-1</name>
        <name evidence="2" type="synonym">svh-6</name>
        <name evidence="5" type="synonym">tag-163</name>
        <name evidence="5" type="ORF">M01E11.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2019" name="J. Neurosci." volume="39" first="5662" last="5672">
            <title>C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Shimizu T."/>
                <person name="Asai K."/>
                <person name="Sakai Y."/>
                <person name="Pastuhov S.I."/>
                <person name="Hanafusa H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="31109965"/>
            <dbReference type="DOI" id="10.1523/jneurosci.2059-18.2019"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SVH-2 AND PAT-3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF 38-MET--SER-335; ARG-1108 AND 1192-ALA--SER-1354</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2L045-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2L045-6</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_060501"/>
        </isoform>
        <isoform>
            <id>H2L045-8</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_060499"/>
        </isoform>
        <isoform>
            <id>H2L045-7</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_060500"/>
        </isoform>
        <isoform>
            <id>H2L045-5</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_060503"/>
        </isoform>
        <isoform>
            <id>H2L045-2</id>
            <name evidence="6">b</name>
            <name evidence="2">tns-1s</name>
            <sequence type="described" ref="VSP_060492"/>
        </isoform>
        <isoform>
            <id>H2L045-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_060502"/>
        </isoform>
        <isoform>
            <id>H2L045-4</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_060505 VSP_060504 VSP_060502"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="RefSeq" id="NP_740854.1">
        <property type="nucleotide sequence ID" value="NM_170867.5"/>
    </dbReference>
    <dbReference type="WormBase" id="M01E11.7d">
        <property type="protein sequence ID" value="CE30558"/>
        <property type="gene ID" value="WBGene00006508"/>
        <property type="gene designation" value="tns-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q63HR2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="31109965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="M01E11.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="M01E11.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="M01E11.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="M01E11.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="M01E11.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="M01E11.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="M01E11.7g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="M01E11.7h"/>
        </source>
    </evidence>
    <sequence length="664" mass="74504" checksum="00282351CE01A8A9" modified="2016-02-17" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-02-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>H2L045-5</accession>
    <name>TENSH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isoform e of Tensin homolog</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">C1 domain-containing phosphatase and tensin homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Suppressor of vhp-1 deletion lethality protein svh-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tns-1</name>
        <name evidence="3" type="synonym">svh-6</name>
        <name evidence="6" type="synonym">tag-163</name>
        <name evidence="6" type="ORF">M01E11.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2019" name="J. Neurosci." volume="39" first="5662" last="5672">
            <title>C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Shimizu T."/>
                <person name="Asai K."/>
                <person name="Sakai Y."/>
                <person name="Pastuhov S.I."/>
                <person name="Hanafusa H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="31109965"/>
            <dbReference type="DOI" id="10.1523/jneurosci.2059-18.2019"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SVH-2 AND PAT-3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF 38-MET--SER-335; ARG-1108 AND 1192-ALA--SER-1354</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Not involved in axon regeneration after injury.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2L045-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_060502 VSP_060505 VSP_060504"/>
        </isoform>
        <isoform>
            <id>H2L045-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2L045-6</id>
            <name evidence="11">f</name>
            <sequence type="described" ref="VSP_060501"/>
        </isoform>
        <isoform>
            <id>H2L045-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_060502"/>
        </isoform>
        <isoform>
            <id>H2L045-2</id>
            <name evidence="7">b</name>
            <name evidence="3">tns-1s</name>
            <sequence type="described" ref="VSP_060492"/>
        </isoform>
        <isoform>
            <id>H2L045-8</id>
            <name evidence="13">h</name>
            <sequence type="described" ref="VSP_060499"/>
        </isoform>
        <isoform>
            <id>H2L045-5</id>
            <name evidence="10">e</name>
            <sequence type="described" ref="VSP_060503"/>
        </isoform>
        <isoform>
            <id>H2L045-7</id>
            <name evidence="12">g</name>
            <sequence type="described" ref="VSP_060500"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001305199.1">
        <property type="nucleotide sequence ID" value="NM_001318270.3"/>
    </dbReference>
    <dbReference type="WormBase" id="M01E11.7e">
        <property type="protein sequence ID" value="CE51160"/>
        <property type="gene ID" value="WBGene00006508"/>
        <property type="gene designation" value="tns-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q63HR2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="31109965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="31109965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="M01E11.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="M01E11.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="M01E11.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="M01E11.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="M01E11.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="M01E11.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="M01E11.7g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="M01E11.7h"/>
        </source>
    </evidence>
    <sequence length="1317" mass="147254" checksum="61E88C879C2E3F60" modified="2016-02-17" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-02-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>H2L045-6</accession>
    <name>TENSH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform f of Tensin homolog</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">C1 domain-containing phosphatase and tensin homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Suppressor of vhp-1 deletion lethality protein svh-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tns-1</name>
        <name evidence="2" type="synonym">svh-6</name>
        <name evidence="5" type="synonym">tag-163</name>
        <name evidence="5" type="ORF">M01E11.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2019" name="J. Neurosci." volume="39" first="5662" last="5672">
            <title>C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Shimizu T."/>
                <person name="Asai K."/>
                <person name="Sakai Y."/>
                <person name="Pastuhov S.I."/>
                <person name="Hanafusa H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="31109965"/>
            <dbReference type="DOI" id="10.1523/jneurosci.2059-18.2019"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SVH-2 AND PAT-3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF 38-MET--SER-335; ARG-1108 AND 1192-ALA--SER-1354</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2L045-5</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_060503"/>
        </isoform>
        <isoform>
            <id>H2L045-4</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_060505 VSP_060504 VSP_060502"/>
        </isoform>
        <isoform>
            <id>H2L045-6</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_060501"/>
        </isoform>
        <isoform>
            <id>H2L045-8</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_060499"/>
        </isoform>
        <isoform>
            <id>H2L045-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_060502"/>
        </isoform>
        <isoform>
            <id>H2L045-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2L045-2</id>
            <name evidence="6">b</name>
            <name evidence="2">tns-1s</name>
            <sequence type="described" ref="VSP_060492"/>
        </isoform>
        <isoform>
            <id>H2L045-7</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_060500"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001305202.1">
        <property type="nucleotide sequence ID" value="NM_001318273.3"/>
    </dbReference>
    <dbReference type="WormBase" id="M01E11.7f">
        <property type="protein sequence ID" value="CE51213"/>
        <property type="gene ID" value="WBGene00006508"/>
        <property type="gene designation" value="tns-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q63HR2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="31109965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="M01E11.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="M01E11.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="M01E11.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="M01E11.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="M01E11.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="M01E11.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="M01E11.7g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="M01E11.7h"/>
        </source>
    </evidence>
    <sequence length="570" mass="62637" checksum="49A4B458237980D0" modified="2016-02-17" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-02-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>H2L045-7</accession>
    <name>TENSH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform g of Tensin homolog</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">C1 domain-containing phosphatase and tensin homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Suppressor of vhp-1 deletion lethality protein svh-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tns-1</name>
        <name evidence="2" type="synonym">svh-6</name>
        <name evidence="5" type="synonym">tag-163</name>
        <name evidence="5" type="ORF">M01E11.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2019" name="J. Neurosci." volume="39" first="5662" last="5672">
            <title>C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Shimizu T."/>
                <person name="Asai K."/>
                <person name="Sakai Y."/>
                <person name="Pastuhov S.I."/>
                <person name="Hanafusa H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="31109965"/>
            <dbReference type="DOI" id="10.1523/jneurosci.2059-18.2019"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SVH-2 AND PAT-3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF 38-MET--SER-335; ARG-1108 AND 1192-ALA--SER-1354</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2L045-6</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_060501"/>
        </isoform>
        <isoform>
            <id>H2L045-5</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_060503"/>
        </isoform>
        <isoform>
            <id>H2L045-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_060502"/>
        </isoform>
        <isoform>
            <id>H2L045-7</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_060500"/>
        </isoform>
        <isoform>
            <id>H2L045-8</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_060499"/>
        </isoform>
        <isoform>
            <id>H2L045-2</id>
            <name evidence="6">b</name>
            <name evidence="2">tns-1s</name>
            <sequence type="described" ref="VSP_060492"/>
        </isoform>
        <isoform>
            <id>H2L045-4</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_060504 VSP_060505 VSP_060502"/>
        </isoform>
        <isoform>
            <id>H2L045-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001305203.1">
        <property type="nucleotide sequence ID" value="NM_001318274.3"/>
    </dbReference>
    <dbReference type="WormBase" id="M01E11.7g">
        <property type="protein sequence ID" value="CE51205"/>
        <property type="gene ID" value="WBGene00006508"/>
        <property type="gene designation" value="tns-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q63HR2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="31109965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="M01E11.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="M01E11.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="M01E11.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="M01E11.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="M01E11.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="M01E11.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="M01E11.7g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="M01E11.7h"/>
        </source>
    </evidence>
    <sequence length="317" mass="34507" checksum="F581583AC34B6BA9" modified="2016-02-17" version="2">MNNRSASPRLFGGSSTLSRRSSVNSVDTSEIIHHHPLFVKDTSKYWYKPTISREQAINMLRDKPPGTFVVRDSNSFPGAFGLALKVSTPPPGVNPGDGSELVRHFLIEPSPKGVKLKGCNNEPVFGSLSALVYQHSITALALPTKLVLPDFDPAATPEHLSATQALLEQGAACNVVYVGSVDVESLTGNECVKRSIATCSQRAINGDSRAVSVHFKVSSQGVTLTDNTRKVFFRRHFNVQSVIFAGMDPIERRFENTRALGFHDGCIAQARLFAFVARIPSSSENACHVFAELEPEQPGSAVVNFINKVMLAQKNRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-02-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>H2L045-8</accession>
    <name>TENSH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform h of Tensin homolog</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">C1 domain-containing phosphatase and tensin homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Suppressor of vhp-1 deletion lethality protein svh-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tns-1</name>
        <name evidence="2" type="synonym">svh-6</name>
        <name evidence="5" type="synonym">tag-163</name>
        <name evidence="5" type="ORF">M01E11.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2019" name="J. Neurosci." volume="39" first="5662" last="5672">
            <title>C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Shimizu T."/>
                <person name="Asai K."/>
                <person name="Sakai Y."/>
                <person name="Pastuhov S.I."/>
                <person name="Hanafusa H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="31109965"/>
            <dbReference type="DOI" id="10.1523/jneurosci.2059-18.2019"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SVH-2 AND PAT-3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF 38-MET--SER-335; ARG-1108 AND 1192-ALA--SER-1354</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2L045-2</id>
            <name evidence="6">b</name>
            <name evidence="2">tns-1s</name>
            <sequence type="described" ref="VSP_060492"/>
        </isoform>
        <isoform>
            <id>H2L045-5</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_060503"/>
        </isoform>
        <isoform>
            <id>H2L045-6</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_060501"/>
        </isoform>
        <isoform>
            <id>H2L045-7</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_060500"/>
        </isoform>
        <isoform>
            <id>H2L045-4</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_060504 VSP_060505 VSP_060502"/>
        </isoform>
        <isoform>
            <id>H2L045-8</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_060499"/>
        </isoform>
        <isoform>
            <id>H2L045-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>H2L045-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_060502"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001305204.1">
        <property type="nucleotide sequence ID" value="NM_001318275.3"/>
    </dbReference>
    <dbReference type="WormBase" id="M01E11.7h">
        <property type="protein sequence ID" value="CE51229"/>
        <property type="gene ID" value="WBGene00006508"/>
        <property type="gene designation" value="tns-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q63HR2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="31109965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="M01E11.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="M01E11.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="M01E11.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="M01E11.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="M01E11.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="M01E11.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="M01E11.7g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="M01E11.7h"/>
        </source>
    </evidence>
    <sequence length="259" mass="27920" checksum="38178C9925884C33" modified="2016-02-17" version="2">MLRDKPPGTFVVRDSNSFPGAFGLALKVSTPPPGVNPGDGSELVRHFLIEPSPKGVKLKGCNNEPVFGSLSALVYQHSITALALPTKLVLPDFDPAATPEHLSATQALLEQGAACNVVYVGSVDVESLTGNECVKRSIATCSQRAINGDSRAVSVHFKVSSQGVTLTDNTRKVFFRRHFNVQSVIFAGMDPIERRFENTRALGFHDGCIAQARLFAFVARIPSSSENACHVFAELEPEQPGSAVVNFINKVMLAQKNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>H7BRC9</accession>
    <name>H7BRC9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 25" type="primary">slo-1</name>
        <name evidence="23" type="ORF">CELE_Y51A2D.19</name>
        <name evidence="25" type="ORF">Y51A2D.19</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="journal article" date="2011" name="Genetics" volume="0" first="0" last="0">
            <title>Cell Excitability Necessary for Male Mating Behavior in Caenorhabditis elegans is Coordinated by Interactions Between BK and EAG Family K+ Channels.</title>
            <authorList>
                <person name="LeBoeuf B."/>
                <person name="Garcia L.R."/>
            </authorList>
            <dbReference type="PubMed" id="22174070"/>
            <dbReference type="DOI" id="10.1534/genetics.111.137455"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2012-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="LeBoeuf B."/>
                <person name="Garcia L.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JQ582463">
        <property type="protein sequence ID" value="AFA28180.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256802.1">
        <property type="nucleotide sequence ID" value="NM_001269873.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H7BRC9"/>
    <dbReference type="SMR" id="H7BRC9"/>
    <dbReference type="PeptideAtlas" id="H7BRC9"/>
    <dbReference type="GeneID" id="180203"/>
    <dbReference type="AGR" id="WB:WBGene00004830"/>
    <dbReference type="CTD" id="180203"/>
    <dbReference type="WormBase" id="Y51A2D.19d">
        <property type="protein sequence ID" value="CE47118"/>
        <property type="gene ID" value="WBGene00004830"/>
        <property type="gene designation" value="slo-1"/>
    </dbReference>
    <dbReference type="OMA" id="YWCKQCH"/>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004830">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H7BRC9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000035">
        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="371"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="819"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AFA28180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCG28224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WormBase" id="Y51A2D.19d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="26">
        <source>
            <dbReference type="PeptideAtlas" id="H7BRC9"/>
        </source>
    </evidence>
    <sequence length="1160" mass="131899" checksum="899FC61F44638D55" modified="2012-04-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>N1NVB4</accession>
    <name>N1NVB4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase 7</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Deubiquitinating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin thioesterase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-specific-processing protease 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">math-33</name>
        <name evidence="16" type="ORF">CELE_H19N07.2</name>
        <name evidence="18" type="ORF">H19N07.2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCW45969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294686.1">
        <property type="nucleotide sequence ID" value="NM_001307757.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1NVB4"/>
    <dbReference type="SMR" id="N1NVB4"/>
    <dbReference type="GeneID" id="179538"/>
    <dbReference type="AGR" id="WB:WBGene00010406"/>
    <dbReference type="CTD" id="179538"/>
    <dbReference type="WormBase" id="H19N07.2o">
        <property type="protein sequence ID" value="CE48339"/>
        <property type="gene ID" value="WBGene00010406"/>
        <property type="gene designation" value="math-33"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010406">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="N1NVB4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000015">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000275">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000044">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00917">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="14">
        <location>
            <begin position="31"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="196"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCW45969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="H19N07.2o"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="N1NVB4"/>
        </source>
    </evidence>
    <sequence length="1132" mass="131255" checksum="A221C99FD439BCA5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>N1NVB5</accession>
    <name>N1NVB5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 12 member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">kcc-1</name>
        <name evidence="9" type="ORF">CELE_R13A1.2</name>
        <name evidence="11" type="ORF">R13A1.2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCW45974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368174.1">
        <property type="nucleotide sequence ID" value="NM_001380315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1NVB5"/>
    <dbReference type="SMR" id="N1NVB5"/>
    <dbReference type="GeneID" id="177495"/>
    <dbReference type="AGR" id="WB:WBGene00006504"/>
    <dbReference type="CTD" id="177495"/>
    <dbReference type="WormBase" id="R13A1.2b">
        <property type="protein sequence ID" value="CE48404"/>
        <property type="gene ID" value="WBGene00006504"/>
        <property type="gene designation" value="kcc-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001883_1_1_1"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006504">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="N1NVB5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015377">
        <property type="term" value="F:chloride:monoatomic cation symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF53">
        <property type="entry name" value="K+_CL-COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="515"/>
        </location>
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        <location>
            <begin position="521"/>
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        <location>
            <begin position="554"/>
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            <begin position="72"/>
            <end position="245"/>
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        <location>
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            <end position="636"/>
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        <location>
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            <end position="774"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PeptideAtlas" id="N1NVB5"/>
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    <sequence length="1035" mass="114337" checksum="5F433ED649ADF224" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>N1NVB8</accession>
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        <submittedName>
            <fullName evidence="19">Multiple epidermal growth factor-like domains protein 6</fullName>
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        <name evidence="19" type="ORF">CELE_Y64G10A.7</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="protein sequence ID" value="CE48342"/>
        <property type="gene ID" value="WBGene00013416"/>
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        <property type="component" value="Chromosome IV"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="WormBase" id="Y64G10A.7c"/>
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    </evidence>
    <sequence length="1612" mass="173224" checksum="5B727852BF8C5399" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>N1NVC0</accession>
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    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C55A6.12</name>
        <name evidence="2" type="ORF">CELE_C55A6.12</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCW45999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294704.1">
        <property type="nucleotide sequence ID" value="NM_001307775.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1NVC0"/>
    <dbReference type="SMR" id="N1NVC0"/>
    <dbReference type="PeptideAtlas" id="N1NVC0"/>
    <dbReference type="GeneID" id="3565529"/>
    <dbReference type="AGR" id="WB:WBGene00044019"/>
    <dbReference type="CTD" id="3565529"/>
    <dbReference type="WormBase" id="C55A6.12b">
        <property type="protein sequence ID" value="CE48367"/>
        <property type="gene ID" value="WBGene00044019"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1391762_0_0_1"/>
    <dbReference type="OrthoDB" id="5861491at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044019">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="N1NVC0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4-like heme-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCW45999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C55A6.12b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="N1NVC0"/>
        </source>
    </evidence>
    <sequence length="98" mass="11692" checksum="62F1CFE534D9D611" modified="2013-06-26" version="1">MPVKNATRRDPRVHVAYLTTSSQGWSMMEQGQVKEGKMTFHLKQFMRRSFDVGNNNNLEIREFERQLELPDYNTMLMKIRAETAYDTETYTATYKRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>N1NVC1</accession>
    <name>N1NVC1_CAEEL</name>
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        <submittedName>
            <fullName evidence="6">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_T24B8.7</name>
        <name evidence="6 8" type="ORF">T24B8.7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCW46004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1NVC1"/>
    <dbReference type="AGR" id="WB:WBGene00011980"/>
    <dbReference type="WormBase" id="T24B8.7h">
        <property type="protein sequence ID" value="CE48346"/>
        <property type="gene ID" value="WBGene00011980"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011980">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="N1NVC1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056850">
        <property type="entry name" value="ARM_UBP34_24_USP9X_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25010">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCW46004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="T24B8.7h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="N1NVC1"/>
        </source>
    </evidence>
    <sequence length="1271" mass="146726" checksum="C28733410FA1BF8D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>N1NVC2</accession>
    <name>N1NVC2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_T24B8.7</name>
        <name evidence="8 10" type="ORF">T24B8.7</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCW46009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293495.1">
        <property type="nucleotide sequence ID" value="NM_001306566.1"/>
    </dbReference>
    <dbReference type="SMR" id="N1NVC2"/>
    <dbReference type="GeneID" id="174440"/>
    <dbReference type="AGR" id="WB:WBGene00011980"/>
    <dbReference type="CTD" id="174440"/>
    <dbReference type="WormBase" id="T24B8.7c">
        <property type="protein sequence ID" value="CE48345"/>
        <property type="gene ID" value="WBGene00011980"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_226625_0_0_1"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011980">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="N1NVC2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056850">
        <property type="entry name" value="ARM_UBP34_24_USP9X_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF933">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25010">
        <property type="entry name" value="ARM_UBP24_USP9X-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="1764"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2019"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2392"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2850"/>
            <end position="2883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2041"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2404"/>
            <end position="2430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCW46009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="T24B8.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="N1NVC2"/>
        </source>
    </evidence>
    <sequence length="2883" mass="334596" checksum="2A8FA1FCCEDB481B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>N1NVC3</accession>
    <name>N1NVC3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">lst-4</name>
        <name evidence="7" type="ORF">CELE_Y37A1B.2</name>
        <name evidence="9" type="ORF">Y37A1B.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCW46014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294088.1">
        <property type="nucleotide sequence ID" value="NM_001307159.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1NVC3"/>
    <dbReference type="SMR" id="N1NVC3"/>
    <dbReference type="PeptideAtlas" id="N1NVC3"/>
    <dbReference type="GeneID" id="178361"/>
    <dbReference type="AGR" id="WB:WBGene00003086"/>
    <dbReference type="CTD" id="178361"/>
    <dbReference type="WormBase" id="Y37A1B.2g">
        <property type="protein sequence ID" value="CE48410"/>
        <property type="gene ID" value="WBGene00003086"/>
        <property type="gene designation" value="lst-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003086">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="N1NVC3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07626">
        <property type="entry name" value="BAR_SNX9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06862">
        <property type="entry name" value="PX_SNX9_18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000033">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000004">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="15"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCW46014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y37A1B.2g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="N1NVC3"/>
        </source>
    </evidence>
    <sequence length="354" mass="41264" checksum="5FA99E0040ECD691" modified="2013-06-26" version="1">MNNGIIQWKPIQQYYTCIVDKPKKESKLKGLKSFIAYSITSSLTNIQRQVSRRYKHFDWLHEQLSAKYVLIPIPPLPEKQVAGRYEEDLIDHRKHILQLWVNKICRHPVLSQSEVWLHFISCTDEKDWKNGKRRAEKDEYIGGAFLNCITVPHQPLDPNNVDMQVERFQRSVKTSEEAMRVMQERMNMFQKVFAGPVKQNWQKMGSAFKTLQQSFEIDETVASRRLTEALAYTASEYHEIGQVFDAHTKNDMEPVLENLYSYKGTVQNVPDIIQVHKQAVQKFRDSEGRLSSAEAEKMKQRIDAMSYTVIAEVQHQTAEKVEDMKSTMGTYLKKQAMFYQEVATKLTSLAARYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>N1NVC4</accession>
    <name>N1NVC4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable 4-aminobutyrate aminotransferase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">gta-1</name>
        <name evidence="8" type="ORF">CELE_K04D7.3</name>
        <name evidence="10" type="ORF">K04D7.3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCW46019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294091.1">
        <property type="nucleotide sequence ID" value="NM_001307162.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1NVC4"/>
    <dbReference type="SMR" id="N1NVC4"/>
    <dbReference type="PeptideAtlas" id="N1NVC4"/>
    <dbReference type="GeneID" id="177897"/>
    <dbReference type="AGR" id="WB:WBGene00001794"/>
    <dbReference type="CTD" id="177897"/>
    <dbReference type="WormBase" id="K04D7.3b">
        <property type="protein sequence ID" value="CE48386"/>
        <property type="gene ID" value="WBGene00001794"/>
        <property type="gene designation" value="gta-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001794">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="N1NVC4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000073">
        <property type="entry name" value="Probable 4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCW46019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="K04D7.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="N1NVC4"/>
        </source>
    </evidence>
    <sequence length="339" mass="37709" checksum="E3BAAF92DF98AABC" modified="2013-06-26" version="1">MLCGTSANENAIKTAFIWYQAQRRGGLGPDALHLESCMNQQKPGTPNLSVMGFEGAFHGRSLCMLSVTRSKPIHKVDIPAFDWPIAKFPRYKYPLDQNVAYNKKQDQECLADVEAKISEWKRRDNDVAAIIVEPIQAEGGDHYGSPAFFQGLRDITSKHGIVFIVDEVQTGGGATGDIWAHDHWNLSSPPDMVTFSKKLLTGGYFYGEHLRVKEAYRIYNTWMGDPTKLLLLEKAVEVIKRDGLIEQSREVGAEFQKRLGELQASSGGKLDQARGRGTFAAVDFPSGSLRDKFVDLAISNGLHCGGCGDRSLRFRPSLVYTKKHLDLTFDLLDKTLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-07-01" modified="2025-10-08" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>O02335</accession>
    <name>O02335_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_W02D9.2</name>
        <name evidence="8 10" type="ORF">W02D9.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB03470.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T26112">
        <property type="entry name" value="T26112"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001251924.1">
        <property type="nucleotide sequence ID" value="NM_001264995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O02335"/>
    <dbReference type="IntAct" id="O02335">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="173123"/>
    <dbReference type="KEGG" id="cel:CELE_W02D9.2"/>
    <dbReference type="UCSC" id="W02D9.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012208"/>
    <dbReference type="CTD" id="173123"/>
    <dbReference type="WormBase" id="W02D9.2a">
        <property type="protein sequence ID" value="CE40140"/>
        <property type="gene ID" value="WBGene00012208"/>
    </dbReference>
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        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
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            <begin position="211"/>
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            <begin position="89"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB03470.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="W02D9.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="O02335"/>
        </source>
    </evidence>
    <sequence length="232" mass="25560" checksum="E8DEB84D5921FC51" modified="2006-04-18" version="2">MNSFGNASVDIDMLEQEMAAEQTANLSGNIAGMSAPKSSSNRRGPMQEVDLDAEFDTLEEPVWDTVKRDVLTVGAKFTHVVLPHGDKQQLLRDWDLWGPLFICVGLALLLQHNGGTESAPQFTQVFTITFFGSVIVTANIKLLGGNISFFQSLCVIGYCLLPPFVAAVLCSLFLHGIAFPLRLLITSIGFVWSTYASMGFLAGCQPDKKRLLVIYPVFLFYFVVSWMIISHS</sequence>
</entry>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T32557"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PeptideAtlas" id="O44189"/>
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    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017998"/>
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        <property type="protein sequence ID" value="CE37228"/>
        <property type="gene ID" value="WBGene00017998"/>
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    <dbReference type="eggNOG" id="ENOG502TGSI">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR055352">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF23626">
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="17"/>
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        </location>
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            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="126"/>
        </location>
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            <begin position="518"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD63772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="O44189"/>
        </source>
    </evidence>
    <sequence length="648" mass="74209" checksum="123B9F9D55D8FB6E" modified="2004-10-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2025-10-08" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>O44197</accession>
    <name>O44197_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">CELE_ZK185.1</name>
        <name evidence="2 4" type="ORF">ZK185.1</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD70164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T32565">
        <property type="entry name" value="T32565"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_500587.2">
        <property type="nucleotide sequence ID" value="NM_068186.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O44197"/>
    <dbReference type="PeptideAtlas" id="O44197"/>
    <dbReference type="GeneID" id="191242"/>
    <dbReference type="UCSC" id="ZK185.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022681"/>
    <dbReference type="CTD" id="191242"/>
    <dbReference type="WormBase" id="ZK185.1a">
        <property type="protein sequence ID" value="CE40733"/>
        <property type="gene ID" value="WBGene00022681"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051735_0_0_1"/>
    <dbReference type="OrthoDB" id="5855987at2759"/>
    <dbReference type="PhylomeDB" id="O44197"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022681">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O44197">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34850:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34850">
        <property type="entry name" value="PROTEIN CBG21297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="312"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD70164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZK185.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="O44197"/>
        </source>
    </evidence>
    <sequence length="360" mass="41203" checksum="D2A6BDF88724B011" modified="2007-03-20" version="2">MDLKFKSQETGRSIGFASHLRRHGATLANHLNYTRNEFISTLADCHQNLGIEGRASSPEKQFDEDGDEIEATATKIEWQPLKCPKCHRNSENTRKLLEHLVEDHGRPQDKAWFEQFDTIGTDLKKVFDKAIRIQAENSVVKKKFQNSNDLLVCPTDSPLAPFLLMRHLQVNFQEVSQTLTEGIVLKLQIASTSYTIIFSFHKVDKARRRIKREMARKSLERRLRVLELRCARTWVPDDDVVFKKKRTSEENKALIQALKLPATSSHDDIVLKINEMKTQHDEMVNNVYTNNVKPNGQIMSAEEKRLISSLTNDMVTPVSGKRKTTFKNPSELQQSSRKRQKTLSPASQSPPEPAATRSEL</sequence>
</entry>
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    <accession>O62303</accession>
    <name>O62303_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">RCC1 domain-containing protein 1</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">CELE_K11D2.1</name>
        <name evidence="2 4" type="ORF">K11D2.1</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB05555.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O62303"/>
    <dbReference type="SMR" id="O62303"/>
    <dbReference type="PaxDb" id="6239-K11D2.1"/>
    <dbReference type="PeptideAtlas" id="O62303"/>
    <dbReference type="UCSC" id="K11D2.1">
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    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010768"/>
    <dbReference type="WormBase" id="K11D2.1a">
        <property type="protein sequence ID" value="CE42141"/>
        <property type="gene ID" value="WBGene00010768"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071685_0_0_1"/>
    <dbReference type="OrthoDB" id="5832952at2759"/>
    <dbReference type="PhylomeDB" id="O62303"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010768">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O62303">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052830">
        <property type="entry name" value="RCC1_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
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        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
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        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="100"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="152"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB05555.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K11D2.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="O62303"/>
        </source>
    </evidence>
    <sequence length="228" mass="25244" checksum="81BC194655AA5B73" modified="2008-03-18" version="2">MAILMKHEKLAVRRLDDFEGNLTFLDLHTDLDVLLVATSREIYAVERSGTSSEIVKILVDSVGISPKKNNLANKIQFPWPVRIVEAAAGHDFLIFRDTTGNLFSMGTGTRGELGVGLIRRVDEPVHIEQLVGIRIKKVACGGWHTVALTEGGDAYTWGWNRYGQLGKDKGSTEVYPVLIDPEEEKFGEENILDVACTEHNTQIVIKTGHAPFVLGTNPTPPINEFHLD</sequence>
</entry>
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    <accession>O62332</accession>
    <name>O62332_CAEEL</name>
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        <submittedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </submittedName>
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        <name evidence="8 10" type="primary">imb-2</name>
        <name evidence="8" type="ORF">CELE_R06A4.4</name>
        <name evidence="10" type="ORF">R06A4.4</name>
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    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAB05586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T23948">
        <property type="entry name" value="T23948"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_496987.1">
        <property type="nucleotide sequence ID" value="NM_064586.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O62332"/>
    <dbReference type="SMR" id="O62332"/>
    <dbReference type="DIP" id="DIP-25178N"/>
    <dbReference type="IntAct" id="O62332">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="PaxDb" id="6239-R06A4.4a"/>
    <dbReference type="PeptideAtlas" id="O62332"/>
    <dbReference type="GeneID" id="175094"/>
    <dbReference type="UCSC" id="R06A4.4b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00002076"/>
    <dbReference type="CTD" id="175094"/>
    <dbReference type="WormBase" id="R06A4.4a">
        <property type="protein sequence ID" value="CE18111"/>
        <property type="gene ID" value="WBGene00002076"/>
        <property type="gene designation" value="imb-2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008136_1_0_1"/>
    <dbReference type="OMA" id="AQEGAMS"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="PhylomeDB" id="O62332"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002076">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O62332">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
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        <property type="entry name" value="Importin-beta_N"/>
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        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25574">
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    <dbReference type="SMART" id="SM00913">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IMPORTIN_B_NT"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB05586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="R06A4.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="O62332"/>
        </source>
    </evidence>
    <sequence length="883" mass="99641" checksum="2055A924892B4A56" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>O62333</accession>
    <name>O62333_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7 9" type="primary">imb-2</name>
        <name evidence="7" type="ORF">CELE_R06A4.4</name>
        <name evidence="9" type="ORF">R06A4.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAB05587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T23949">
        <property type="entry name" value="T23949"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_496988.1">
        <property type="nucleotide sequence ID" value="NM_064587.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O62333"/>
    <dbReference type="SMR" id="O62333"/>
    <dbReference type="IntAct" id="O62333">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="O62333"/>
    <dbReference type="GeneID" id="175094"/>
    <dbReference type="UCSC" id="R06A4.4b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00002076"/>
    <dbReference type="CTD" id="175094"/>
    <dbReference type="WormBase" id="R06A4.4b">
        <property type="protein sequence ID" value="CE18112"/>
        <property type="gene ID" value="WBGene00002076"/>
        <property type="gene designation" value="imb-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008136_2_1_1"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002076">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O62333">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
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        <property type="entry name" value="Importin_beta"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="6">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB05587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="R06A4.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="O62333"/>
        </source>
    </evidence>
    <sequence length="419" mass="46824" checksum="355DAA943B84AEFC" modified="1998-08-01" version="1">MAFQPDQHELEQLLRCSLDGNKKVQEAACSAFATLEEEAGEQLIPFLGEILDQLVKAFQCYQAKNLLILYDAIGTLANSVGDALSHPVYVQMLMPPLMEKWERLSDEDKELFPLLECISAIVSAMGQSFLPYIQPVFTRCCSLIEKCVQQNQQHIMAPDQVEAPETDFIIVALDLLSGLAESLPEHMDPLVANSKLVELMLFCSLDVTPDVRQSCFALLGDLTKACPERVLPQSSNFIFFLAQNLDPSKISVCNNAIWALGELALKMGPAMKQFIGPIIEPLIVVINSQQNMQRTLLENTAITIGRLGQCCGEELAPHISRFVRPCCYSLRNIKDNAEKESAFIGLCNMINMNPVGVLNDFIFWCDAIASWTVPTDSLRVLFAGILQSFKQQVGDFNWNNFILQLPPPLRERLSAFYQI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-04-01" modified="2026-01-28" version="163" xmlns="https://uniprot.org/uniprot">
    <accession>P15796-2</accession>
    <name>H12_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Histone H1.2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Histone H1-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">hil-2</name>
        <name type="ORF">Y73B6BL.9</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Biochem. J." volume="265" first="739" last="746">
            <title>The primary structure of a minor isoform (H1.2) of histone H1 from the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Vanfleteren J.R."/>
                <person name="van Bun S.M."/>
                <person name="de Baere I."/>
                <person name="van Beeumen J.J."/>
            </authorList>
            <dbReference type="PubMed" id="2407235"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 2-191 (ISOFORM A)</scope>
        <scope>ACETYLATION AT SER-2</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Development" volume="128" first="1069" last="1080">
            <title>A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Jedrusik M.A."/>
                <person name="Schulze E."/>
            </authorList>
            <dbReference type="PubMed" id="11245572"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM A)</scope>
        <source>
            <strain>Bristol N2</strain>
            <strain>him-8</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P15796-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_011759"/>
        </isoform>
        <isoform>
            <id>P15796-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741418.2">
        <property type="nucleotide sequence ID" value="NM_171909.8"/>
    </dbReference>
    <dbReference type="WormBase" id="Y73B6BL.9b">
        <property type="protein sequence ID" value="CE46839"/>
        <property type="gene ID" value="WBGene00001853"/>
        <property type="gene designation" value="hil-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="123" mass="12592" checksum="4E524AECBEE9525D" modified="2007-01-23" version="3">MSDVTVAETPAVKTPTKAPKAPKSKTTKEPKAKVAAAHPPFINMVTAAATKKPVAKKPVAKKAATGEKKAKKTTVAKKTGDKVKKAKSPKKIAKPAAKKVAKSPAKKAAPKKAPAKKAAAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-05-01" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>P91855</accession>
    <name>P91855_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatase and actin regulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">phac-1</name>
        <name evidence="6" type="ORF">CELE_F26H9.2</name>
        <name evidence="8" type="ORF">F26H9.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB04203.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_492478.2">
        <property type="nucleotide sequence ID" value="NM_060077.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P91855"/>
    <dbReference type="SMR" id="P91855"/>
    <dbReference type="STRING" id="6239.F26H9.2.1"/>
    <dbReference type="PaxDb" id="6239-F26H9.2"/>
    <dbReference type="GeneID" id="172753"/>
    <dbReference type="UCSC" id="F26H9.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009174"/>
    <dbReference type="CTD" id="172753"/>
    <dbReference type="WormBase" id="F26H9.2a">
        <property type="protein sequence ID" value="CE43857"/>
        <property type="gene ID" value="WBGene00009174"/>
        <property type="gene designation" value="phac-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479977_0_0_1"/>
    <dbReference type="InParanoid" id="P91855"/>
    <dbReference type="OMA" id="EAKEPNF"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="PhylomeDB" id="P91855"/>
    <dbReference type="Reactome" id="R-CEL-114608">
        <property type="pathway name" value="Platelet degranulation"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009174">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB04203.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F26H9.2a"/>
        </source>
    </evidence>
    <sequence length="508" mass="56912" checksum="287B0BA3B3D0E041" modified="2009-09-01" version="2">MTSNEDVSSRHVTKVKKSTVSDATSSTSGGSKSKTGRSPRKSISFASSKFWLRLVRPWKWRNLRRKVRRSDSERSSSQNRANSVSNFPRTSPSLPELSSIVREDSAEMKASGSNDNSEAITYRPATSSASTNHAENSEPQPLIVDPTHISIVRTKIQDPSPDPSGASSEIQRVQFIQSTSTANPAIFTAPPPPPSLVIQPPPPGDRDSDEENINYDQSTESEGEEDMNRSADRRGELSPQTSRMLKEGYRRIEAKEPNFTAQPDKPNLRRPGQPSRLRLNGKTGKSSKEDTELPSKLTDDSDSDAPIQYRDDPISVAAAAARRAANVAPPGSSTDEDDDEEEDVPIPRNGLASKVARRDTMALKLDAPPCKNDINGQTADDRKKLMKTASIKLARKLSERPTPEELEDRNILRRRGMTSSEAMEEKRKLLLRKLSFRPTIKELKEQQIIQFADYVEVTQAEVYDRKTDKPWTRLTPSDKAMIRKELNDFKATEMDVHEESRVFTRFHR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-07-06" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q0G838-2</accession>
    <name>IFT46_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Intraflagellar transport protein 46 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Abnormal dye filling protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dyf-6</name>
        <name evidence="5" type="ORF">F46F6.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1995" name="Genetics" volume="139" first="171" last="188">
            <title>Mutations affecting the chemosensory neurons of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Starich T.A."/>
                <person name="Herman R.K."/>
                <person name="Kari C.K."/>
                <person name="Yeh W.H."/>
                <person name="Schackwitz W.S."/>
                <person name="Schuyler M.W."/>
                <person name="Collet J."/>
                <person name="Thomas J.H."/>
                <person name="Riddle D.L."/>
            </authorList>
            <dbReference type="PubMed" id="7705621"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2006" name="Genetics" volume="173" first="1275" last="1286">
            <title>The molecular identities of the Caenorhabditis elegans intraflagellar transport genes dyf-6, daf-10 and osm-1.</title>
            <authorList>
                <person name="Bell L.R."/>
                <person name="Stone S."/>
                <person name="Yochem J."/>
                <person name="Shaw J.E."/>
                <person name="Herman R.K."/>
            </authorList>
            <dbReference type="PubMed" id="16648645"/>
            <dbReference type="DOI" id="10.1534/genetics.106.056721"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="1448" last="1461">
            <title>Dynein-driven retrograde intraflagellar transport is triphasic in C. elegans sensory cilia.</title>
            <authorList>
                <person name="Yi P."/>
                <person name="Li W.J."/>
                <person name="Dong M.Q."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="28479320"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.04.015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN IFT COMPLEX B</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q0G838-2</id>
            <name evidence="6">b</name>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_058390"/>
        </isoform>
        <isoform>
            <id>Q0G838-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_058391 VSP_058392"/>
        </isoform>
        <isoform>
            <id>Q0G838-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q0G838-4</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_058390 VSP_058393"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379460.1">
        <property type="nucleotide sequence ID" value="NM_001392834.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F46F6.4c">
        <property type="protein sequence ID" value="CE40389"/>
        <property type="gene ID" value="WBGene00001122"/>
        <property type="gene designation" value="dyf-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9NQC8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="ABC88649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F46F6.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F46F6.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F46F6.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="F46F6.4d"/>
        </source>
    </evidence>
    <sequence length="320" mass="36298" checksum="B02A1C6567CF88BF" modified="2006-10-03" version="1">MAANGEFEEEFNDLADPQVQPPPMGSPPAYTSADEGPKTPPPRASAGSNMRQESMNELIMRKISDPLQNLIRRASRLEDDSSNDDDDDDDDEDDDYTEDEIAILTYIDAYKTQEVELRPQLRPFTIEYIPAMGDVDLFIKVPRPDEIDDNVGLTQIDEPPSNQSDATIVDMQIRNATKDAAILDDDVPVKLLERADENPDEIKKWISDIKEFHKSKPAQTVHYRTQLPDVETLMQEWPQKLEEVLKTTKIPSAELDVSLEKYVEICLNIVDIPVGKSRIEALHLMFSLLNEFNNSQHFRNLAQNNNLGGETGETMDRLEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-07-06" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q0G838-3</accession>
    <name>IFT46_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Intraflagellar transport protein 46 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Abnormal dye filling protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dyf-6</name>
        <name evidence="5" type="ORF">F46F6.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1995" name="Genetics" volume="139" first="171" last="188">
            <title>Mutations affecting the chemosensory neurons of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Starich T.A."/>
                <person name="Herman R.K."/>
                <person name="Kari C.K."/>
                <person name="Yeh W.H."/>
                <person name="Schackwitz W.S."/>
                <person name="Schuyler M.W."/>
                <person name="Collet J."/>
                <person name="Thomas J.H."/>
                <person name="Riddle D.L."/>
            </authorList>
            <dbReference type="PubMed" id="7705621"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2006" name="Genetics" volume="173" first="1275" last="1286">
            <title>The molecular identities of the Caenorhabditis elegans intraflagellar transport genes dyf-6, daf-10 and osm-1.</title>
            <authorList>
                <person name="Bell L.R."/>
                <person name="Stone S."/>
                <person name="Yochem J."/>
                <person name="Shaw J.E."/>
                <person name="Herman R.K."/>
            </authorList>
            <dbReference type="PubMed" id="16648645"/>
            <dbReference type="DOI" id="10.1534/genetics.106.056721"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="1448" last="1461">
            <title>Dynein-driven retrograde intraflagellar transport is triphasic in C. elegans sensory cilia.</title>
            <authorList>
                <person name="Yi P."/>
                <person name="Li W.J."/>
                <person name="Dong M.Q."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="28479320"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.04.015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN IFT COMPLEX B</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q0G838-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q0G838-4</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_058390 VSP_058393"/>
        </isoform>
        <isoform>
            <id>Q0G838-2</id>
            <name evidence="6">b</name>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_058390"/>
        </isoform>
        <isoform>
            <id>Q0G838-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_058391 VSP_058392"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001076768.1">
        <property type="nucleotide sequence ID" value="NM_001083299.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F46F6.4b">
        <property type="protein sequence ID" value="CE02236"/>
        <property type="gene ID" value="WBGene00001122"/>
        <property type="gene designation" value="dyf-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9NQC8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="ABC88649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F46F6.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F46F6.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F46F6.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="F46F6.4d"/>
        </source>
    </evidence>
    <sequence length="158" mass="18020" checksum="010175A75EDB2E48" modified="2006-10-03" version="1">MSSETTAPMIINEKSSLPVKSEPGQLGNPISDESSEDEQSQIRALEEDQGIYYNEEVVASPKNESDDDIPLRRIQLSHQTSTQQHPEDSEPQEVIDVNDIELPAGEAQPNMERRRSVRFSGRHDEEEDGRNKHFRTPSPESLRYIQVTLFIEAFINQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-07-06" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q0G838-4</accession>
    <name>IFT46_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of Intraflagellar transport protein 46 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Abnormal dye filling protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dyf-6</name>
        <name evidence="5" type="ORF">F46F6.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1995" name="Genetics" volume="139" first="171" last="188">
            <title>Mutations affecting the chemosensory neurons of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Starich T.A."/>
                <person name="Herman R.K."/>
                <person name="Kari C.K."/>
                <person name="Yeh W.H."/>
                <person name="Schackwitz W.S."/>
                <person name="Schuyler M.W."/>
                <person name="Collet J."/>
                <person name="Thomas J.H."/>
                <person name="Riddle D.L."/>
            </authorList>
            <dbReference type="PubMed" id="7705621"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2006" name="Genetics" volume="173" first="1275" last="1286">
            <title>The molecular identities of the Caenorhabditis elegans intraflagellar transport genes dyf-6, daf-10 and osm-1.</title>
            <authorList>
                <person name="Bell L.R."/>
                <person name="Stone S."/>
                <person name="Yochem J."/>
                <person name="Shaw J.E."/>
                <person name="Herman R.K."/>
            </authorList>
            <dbReference type="PubMed" id="16648645"/>
            <dbReference type="DOI" id="10.1534/genetics.106.056721"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="1448" last="1461">
            <title>Dynein-driven retrograde intraflagellar transport is triphasic in C. elegans sensory cilia.</title>
            <authorList>
                <person name="Yi P."/>
                <person name="Li W.J."/>
                <person name="Dong M.Q."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="28479320"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.04.015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN IFT COMPLEX B</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q0G838-2</id>
            <name evidence="6">b</name>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_058390"/>
        </isoform>
        <isoform>
            <id>Q0G838-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_058392 VSP_058391"/>
        </isoform>
        <isoform>
            <id>Q0G838-4</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_058390 VSP_058393"/>
        </isoform>
        <isoform>
            <id>Q0G838-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001076770.1">
        <property type="nucleotide sequence ID" value="NM_001083301.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F46F6.4d">
        <property type="protein sequence ID" value="CE40390"/>
        <property type="gene ID" value="WBGene00001122"/>
        <property type="gene designation" value="dyf-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9NQC8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="ABC88649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F46F6.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F46F6.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F46F6.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="F46F6.4d"/>
        </source>
    </evidence>
    <sequence length="298" mass="33631" checksum="620617B181B3E3E6" modified="2006-10-03" version="1">MAANGEFEEEFNDLADPQVQPPPMGSPPAYTSADEGPKTPPPRASAGSNMRASRLEDDSSNDDDDDDDDEDDDYTEDEIAILTYIDAYKTQEVELRPQLRPFTIEYIPAMGDVDLFIKVPRPDEIDDNVGLTQIDEPPSNQSDATIVDMQIRNATKDAAILDDDVPVKLLERADENPDEIKKWISDIKEFHKSKPAQTVHYRTQLPDVETLMQEWPQKLEEVLKTTKIPSAELDVSLEKYVEICLNIVDIPVGKSRIEALHLMFSLLNEFNNSQHFRNLAQNNNLGGETGETMDRLEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-12" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q22670-2</accession>
    <name>RBGPR_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Rab3 GTPase-activating protein regulatory subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Rab3 GTPase-activating protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rbg-2</name>
        <name type="ORF">T22C1.10</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q22670-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_013314"/>
        </isoform>
        <isoform>
            <id>Q22670-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021632.1">
        <property type="nucleotide sequence ID" value="NM_001026461.5"/>
    </dbReference>
    <dbReference type="WormBase" id="T22C1.10b">
        <property type="protein sequence ID" value="CE36203"/>
        <property type="gene ID" value="WBGene00004318"/>
        <property type="gene designation" value="rbg-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="1291" mass="148252" checksum="9760D7220875E91B" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q23013</accession>
    <name>Q23013_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">tyra-3</name>
        <name evidence="14" type="ORF">CELE_M03F4.3</name>
        <name evidence="16" type="ORF">M03F4.3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD83479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T25837">
        <property type="entry name" value="T25837"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024804.1">
        <property type="nucleotide sequence ID" value="NM_001029633.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q23013"/>
    <dbReference type="GeneID" id="187427"/>
    <dbReference type="KEGG" id="cel:CELE_M03F4.3"/>
    <dbReference type="UCSC" id="M03F4.3c.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006475"/>
    <dbReference type="CTD" id="187427"/>
    <dbReference type="WormBase" id="M03F4.3a">
        <property type="protein sequence ID" value="CE31203"/>
        <property type="gene ID" value="WBGene00006475"/>
        <property type="gene designation" value="tyra-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6358729at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006475">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q23013">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15061">
        <property type="entry name" value="7tmA_tyramine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000311">
        <property type="entry name" value="TYRAmine receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000454">
        <property type="entry name" value="TYRAmine receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="88"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD83479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="M03F4.3a"/>
        </source>
    </evidence>
    <sequence length="564" mass="63275" checksum="774931C2279DA67D" modified="2002-10-01" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q2WF59-2</accession>
    <name>ZER1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Zyg eleven-related protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>zyg-11-related protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">zer-1</name>
        <name type="ORF">T24C4.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="EMBO Rep." volume="8" first="279" last="286">
            <title>The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components.</title>
            <authorList>
                <person name="Vasudevan S."/>
                <person name="Starostina N.G."/>
                <person name="Kipreos E.T."/>
            </authorList>
            <dbReference type="PubMed" id="17304241"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7400895"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ELC-1</scope>
        <scope>IDENTIFICATION IN COMPLEX WITH CUL-2 AND ELC-1</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q2WF59-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_028229"/>
        </isoform>
        <isoform>
            <id>Q2WF59-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741090.3">
        <property type="nucleotide sequence ID" value="NM_171079.10"/>
    </dbReference>
    <dbReference type="WormBase" id="T24C4.6a">
        <property type="protein sequence ID" value="CE39414"/>
        <property type="gene ID" value="WBGene00020762"/>
        <property type="gene designation" value="zer-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="860" mass="97230" checksum="AF0901582BE6556F" modified="2006-01-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-07-19" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q4PIU4</accession>
    <name>Q4PIU4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">gon-14</name>
        <name evidence="3" type="ORF">CELE_F44C4.4</name>
        <name evidence="5" type="ORF">F44C4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD71206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741558.2">
        <property type="nucleotide sequence ID" value="NM_171476.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4PIU4"/>
    <dbReference type="PeptideAtlas" id="Q4PIU4"/>
    <dbReference type="GeneID" id="179052"/>
    <dbReference type="UCSC" id="F44C4.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00002148"/>
    <dbReference type="CTD" id="179052"/>
    <dbReference type="WormBase" id="F44C4.4b">
        <property type="protein sequence ID" value="CE38824"/>
        <property type="gene ID" value="WBGene00002148"/>
        <property type="gene designation" value="gon-14"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5802562at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002148">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q4PIU4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030421">
        <property type="term" value="P:defecation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035262">
        <property type="term" value="P:gonad morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040027">
        <property type="term" value="P:negative regulation of vulval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043051">
        <property type="term" value="P:regulation of nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040129">
        <property type="entry name" value="Lin-15B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22716">
        <property type="entry name" value="ETS CLASS TRANSCRIPTION FACTOR-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22716:SF3">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="649"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD71206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F44C4.4b"/>
        </source>
    </evidence>
    <sequence length="883" mass="100649" checksum="A1FCBBB7FBF304C7" modified="2005-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-07-19" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>Q4PIU9</accession>
    <name>Q4PIU9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuroglian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">sax-7</name>
        <name evidence="15" type="ORF">C18F3.2</name>
        <name evidence="13" type="ORF">CELE_C18F3.2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD65185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001033395.1">
        <property type="nucleotide sequence ID" value="NM_001038306.6"/>
    </dbReference>
    <dbReference type="SMR" id="Q4PIU9"/>
    <dbReference type="PeptideAtlas" id="Q4PIU9"/>
    <dbReference type="GeneID" id="177602"/>
    <dbReference type="UCSC" id="C18F3.2b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004732"/>
    <dbReference type="CTD" id="177602"/>
    <dbReference type="WormBase" id="C18F3.2b">
        <property type="protein sequence ID" value="CE38779"/>
        <property type="gene ID" value="WBGene00004732"/>
        <property type="gene designation" value="sax-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005756_1_0_1"/>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004732">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q4PIU9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030506">
        <property type="term" value="F:ankyrin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003384">
        <property type="term" value="P:apical constriction involved in gastrulation"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042074">
        <property type="term" value="P:cell migration involved in gastrulation"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001718">
        <property type="entry name" value="Neuroglian, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001687">
        <property type="entry name" value="Neuroglian, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002338">
        <property type="entry name" value="Sensory AXon guidance"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002456">
        <property type="entry name" value="Sensory AXon guidance"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002669">
        <property type="entry name" value="Sensory AXon guidance"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002807">
        <property type="entry name" value="Sensory AXon guidance"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002942">
        <property type="entry name" value="Sensory AXon guidance"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="377" mass="41543" checksum="A5EA1DAEDC7B8EA9" modified="2004-12-07" version="1">MEGSSTYSSTSQTDTEDGSRMHGTDVVFDDETAMRRKTMDEENIATKKSTPIMIFLNATIIGLVAITWCLSTQFSKTALNFDKKHFNAPYFMMWFNTNLMILCFPAYIIVDKLRSRRTVNVIVGETFRTFGKKKGFNIRNLFIYVTPFVVFWVGANYPYVRALLLISPSVATSISACNAAFVYILAIIVLGDTINIFKILSVVLAIGGVVVISLDNEMKVEWVGIMCAVISAFMAAVYKVTFKRVIGNASLGDVSLFMSCLGFLNLCINWVPALILALTGVETLQFAYAPWGPMVGAALLSMAFNFTINFGIALLNPLVISVGMLCGIPLNTVIDILFRGLETTTLFLVGTCLIILSFILIIIPYDKLNIGGNLKQC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q7YTU4-2</accession>
    <name>ERO1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Endoplasmic reticulum oxidoreductin-1</fullName>
            <ecNumber evidence="1">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ero-1</name>
        <name type="ORF">Y105E8B.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q7YTU4-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_036006"/>
        </isoform>
        <isoform>
            <id>Q7YTU4-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001364632.1">
        <property type="nucleotide sequence ID" value="NM_001377682.2"/>
    </dbReference>
    <dbReference type="WormBase" id="Y105E8B.8b">
        <property type="protein sequence ID" value="CE42762"/>
        <property type="gene ID" value="WBGene00001334"/>
        <property type="gene designation" value="ero-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q96HE7"/>
        </source>
    </evidence>
    <sequence length="339" mass="39332" checksum="26882FB12842D40B" modified="2004-07-19" version="2" precursor="true">MDRTLHDDEKRQLDAMDHHDDGLEDKFCEIEDDESDGMHYVDLSKNPERYTGYAGKSPQRVWKSIYEENCFKPDPKFDKNFLTNPSNFGMCLEKRVFYRLISGLHSAITISIAAYNYKPPPPSLGQFGSQMGTWFRNTEMFAGRFGTKWSWEGPQRLRNVYFIYLLELRALLKAAPYLQNELFYTGNDVEDAETRKAVEDLLEEIRAYPNHFDESEMFTGVESHARALREEFRSHFVNISRIMDCVECDKCRLWGKVQTHGMGTALKILFSDLPHSHYKQDSSKFQLTRNEVVALLQSFGRYSSSILEVDNFREDMYPGESVMNTAADGPPRKSNKIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q86FM9</accession>
    <name>Q86FM9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydantoinase B/oxoprolinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y38F2AR.12</name>
        <name evidence="2 4" type="ORF">Y38F2AR.12</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD67387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86FM9"/>
    <dbReference type="SMR" id="Q86FM9"/>
    <dbReference type="PeptideAtlas" id="Q86FM9"/>
    <dbReference type="UCSC" id="Y38F2AR.12a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021430"/>
    <dbReference type="WormBase" id="Y38F2AR.12b">
        <property type="protein sequence ID" value="CE33863"/>
        <property type="gene ID" value="WBGene00021430"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020413_0_0_1"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021430">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86FM9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD67387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y38F2AR.12b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q86FM9"/>
        </source>
    </evidence>
    <sequence length="516" mass="55707" checksum="5A33270E3E67884C" modified="2003-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q86FN6</accession>
    <name>Q86FN6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y54G2A.26</name>
        <name evidence="2 4" type="ORF">Y54G2A.26</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD83517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023500.1">
        <property type="nucleotide sequence ID" value="NM_001028329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86FN6"/>
    <dbReference type="PeptideAtlas" id="Q86FN6"/>
    <dbReference type="GeneID" id="177079"/>
    <dbReference type="UCSC" id="Y54G2A.26a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021890"/>
    <dbReference type="CTD" id="177079"/>
    <dbReference type="WormBase" id="Y54G2A.26b">
        <property type="protein sequence ID" value="CE33888"/>
        <property type="gene ID" value="WBGene00021890"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042198_0_0_1"/>
    <dbReference type="OrthoDB" id="5817233at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021890">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86FN6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD83517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y54G2A.26b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q86FN6"/>
        </source>
    </evidence>
    <sequence length="549" mass="59221" checksum="CCEEFC8D25D0C8A4" modified="2003-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q95X35-2</accession>
    <name>MPPE1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Metallophosphoesterase 1 homolog</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mppe-1</name>
        <name evidence="2" type="ORF">B0511.13</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95X35-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95X35-2</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_060217"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="RefSeq" id="NP_001251442.2">
        <property type="nucleotide sequence ID" value="NM_001264513.4"/>
    </dbReference>
    <dbReference type="WormBase" id="B0511.13a">
        <property type="protein sequence ID" value="CE50716"/>
        <property type="gene ID" value="WBGene00015238"/>
        <property type="gene designation" value="mppe-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="B0511.13a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="B0511.13b"/>
        </source>
    </evidence>
    <sequence length="224" mass="26311" checksum="7EA83CB2D9D20C37" modified="2019-07-03" version="3">MPETLEMFKKEFRRGLIDEMKIKKHRFVLINSMAMHGDGCRLCHEAELILEKIKSRNPKNRPIVLQHFPLYRKSDAECDQVDEQHEIDLKEMYREQWDTLSKESSLQIIDSLNPKAVFGGHTHKMCKKKWNKTGNSEYFYEYTVNSFSWRNGDVPAMLLVVIDGDNVLVSSCRLPSEILQIMVYIFGGIGIVILAFILISRRVRIFKRRPSYSLLMYRSQEKCD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-02-10" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N303-2</accession>
    <name>DEPS1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of P-granule-associated protein deps-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Defective P granules and sterile protein deps-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">deps-1</name>
        <name evidence="4" type="ORF">Y65B4BL.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2008" name="Development" volume="135" first="983" last="993">
            <title>DEPS-1 promotes P-granule assembly and RNA interference in C. elegans germ cells.</title>
            <authorList>
                <person name="Spike C.A."/>
                <person name="Bader J."/>
                <person name="Reinke V."/>
                <person name="Strome S."/>
            </authorList>
            <dbReference type="PubMed" id="18234720"/>
            <dbReference type="DOI" id="10.1242/dev.015552"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 116-ARG--VAL-619 AND 408-GLN--VAL-619</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2016" name="Cell" volume="165" first="88" last="99">
            <title>A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans.</title>
            <authorList>
                <person name="Houri-Ze'evi L."/>
                <person name="Korem Y."/>
                <person name="Sheftel H."/>
                <person name="Faigenbloom L."/>
                <person name="Toker I.A."/>
                <person name="Dagan Y."/>
                <person name="Awad L."/>
                <person name="Degani L."/>
                <person name="Alon U."/>
                <person name="Rechavi O."/>
            </authorList>
            <dbReference type="PubMed" id="27015309"/>
            <dbReference type="DOI" id="10.1016/j.cell.2016.02.057"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2018" name="Nature" volume="557" first="679" last="683">
            <title>Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance.</title>
            <authorList>
                <person name="Wan G."/>
                <person name="Fields B.D."/>
                <person name="Spracklin G."/>
                <person name="Shukla A."/>
                <person name="Phillips C.M."/>
                <person name="Kennedy S."/>
            </authorList>
            <dbReference type="PubMed" id="29769721"/>
            <dbReference type="DOI" id="10.1038/s41586-018-0132-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 116-ARG--VAL-619</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="4242" last="4242">
            <title>DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Suen K.M."/>
                <person name="Braukmann F."/>
                <person name="Butler R."/>
                <person name="Bensaddek D."/>
                <person name="Akay A."/>
                <person name="Lin C.C."/>
                <person name="Milonaityte D."/>
                <person name="Doshi N."/>
                <person name="Sapetschnig A."/>
                <person name="Lamond A."/>
                <person name="Ladbury J.E."/>
                <person name="Miska E.A."/>
            </authorList>
            <dbReference type="PubMed" id="32843637"/>
            <dbReference type="DOI" id="10.1038/s41467-020-18089-1"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH EDG-1 AND PRG-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF 102-HIS--VAL-619 AND 116-ARG--VAL-619</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9N303-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_060860"/>
        </isoform>
        <isoform>
            <id>Q9N303-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001293193.1">
        <property type="nucleotide sequence ID" value="NM_001306264.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y65B4BL.2b">
        <property type="protein sequence ID" value="CE49430"/>
        <property type="gene ID" value="WBGene00022034"/>
        <property type="gene designation" value="deps-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="18234720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y65B4BL.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y65B4BL.2b"/>
        </source>
    </evidence>
    <sequence length="574" mass="64228" checksum="5940450E7F573BC0" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N3Z2</accession>
    <name>Q9N3Z2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">oac-55</name>
        <name evidence="4" type="ORF">CELE_Y39H10A.2</name>
        <name evidence="6" type="ORF">Y39H10A.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD73283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_504041.1">
        <property type="nucleotide sequence ID" value="NM_071640.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N3Z2"/>
    <dbReference type="PaxDb" id="6239-Y39H10A.2"/>
    <dbReference type="GeneID" id="178792"/>
    <dbReference type="UCSC" id="Y39H10A.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021479"/>
    <dbReference type="CTD" id="178792"/>
    <dbReference type="WormBase" id="Y39H10A.2a">
        <property type="protein sequence ID" value="CE21778"/>
        <property type="gene ID" value="WBGene00021479"/>
        <property type="gene designation" value="oac-55"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007874_3_2_1"/>
    <dbReference type="OMA" id="SEWWAFI"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="PhylomeDB" id="Q9N3Z2"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021479">
        <property type="expression patterns" value="Expressed in embryo and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N3Z2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF55">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004330257" evidence="2">
        <location>
            <begin position="24"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD73283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y39H10A.2a"/>
        </source>
    </evidence>
    <sequence length="740" mass="84488" checksum="E9FF41C6D7B11D2F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="165" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N5B7</accession>
    <name>Q9N5B7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dynamin-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">rme-1</name>
        <name evidence="15" type="ORF">CELE_W06H8.1</name>
        <name evidence="17" type="ORF">W06H8.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD72158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379996.1">
        <property type="nucleotide sequence ID" value="NM_001392527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N5B7"/>
    <dbReference type="SMR" id="Q9N5B7"/>
    <dbReference type="DIP" id="DIP-27284N"/>
    <dbReference type="PaxDb" id="6239-W06H8.1b"/>
    <dbReference type="PeptideAtlas" id="Q9N5B7"/>
    <dbReference type="GeneID" id="179010"/>
    <dbReference type="UCSC" id="W06H8.1c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004373"/>
    <dbReference type="CTD" id="179010"/>
    <dbReference type="WormBase" id="W06H8.1a">
        <property type="protein sequence ID" value="CE25146"/>
        <property type="gene ID" value="WBGene00004373"/>
        <property type="gene designation" value="rme-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017595_3_0_1"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004373">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N5B7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060990">
        <property type="term" value="P:lipid tube assembly involved in organelle fission"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070266">
        <property type="term" value="P:necroptotic process"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
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            <begin position="1"/>
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            <dbReference type="PeptideAtlas" id="Q9N5B7"/>
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    <sequence length="786" mass="88558" checksum="17278EEB518DB5F5" modified="2000-10-01" version="1"> </sequence>
</entry>
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            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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    <sequence length="346" mass="39680" checksum="EE4E1187F5DF113C" modified="2000-05-01" version="1">MSDNNTIRMSRVLCDFLVLTLIAIPLYVFHEFIPPVRRGFYCDDESIRYPFRDSKVTRQMLIVVGLLIPILLILATELFRTLAWEKKCETEFKTYHVRNHSVHRLVVRLYCFIGYFFVGVCFNQLMVDIAKYTIGRQRPHFMDVCRPDIGYQTCSQPDLYITDFKCTTTDTKKIHEAQLSFYSGHSAFSFYAAWFTSLYLQARLFRPLFSRLLLPVIQFLLFGGAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFVALFVAEVFKRREIPSCGPSNEFGLIRMDRPDGVSNANGNGSNTVVSTQHVIVSEVDPANQRLKTNPKDTVPTMVHPDQVKPHFIEINHL</sequence>
</entry>
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        <submittedName>
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        <name evidence="2 4" type="ORF">H05C05.1</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
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        <property type="gene ID" value="WBGene00019157"/>
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    <dbReference type="HOGENOM" id="CLU_015506_0_0_1"/>
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        <property type="component" value="Chromosome III"/>
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    </dbReference>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD72188.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="H05C05.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q9TXU2"/>
        </source>
    </evidence>
    <sequence length="834" mass="90061" checksum="083256F00BF23C33" modified="2020-06-17" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2026-01-28" version="192" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TXV2</accession>
    <name>Q9TXV2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">tat-2</name>
        <name evidence="19" type="ORF">CELE_H06H21.10</name>
        <name evidence="21" type="ORF">H06H21.10</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD72226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023252.2">
        <property type="nucleotide sequence ID" value="NM_001028081.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9TXV2"/>
    <dbReference type="GeneID" id="177256"/>
    <dbReference type="KEGG" id="cel:CELE_H06H21.10"/>
    <dbReference type="UCSC" id="H06H21.10b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019166"/>
    <dbReference type="CTD" id="177256"/>
    <dbReference type="WormBase" id="H06H21.10a">
        <property type="protein sequence ID" value="CE45939"/>
        <property type="gene ID" value="WBGene00019166"/>
        <property type="gene designation" value="tat-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_3_2_1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="PhylomeDB" id="Q9TXV2"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019166">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9TXV2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000107">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF190">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="916"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="944"/>
            <end position="965"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="986"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1032"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1064"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1109"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="881"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1262"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1288"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="410"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="411"/>
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        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="13">
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        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="412"/>
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        <ligand>
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    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="513"/>
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        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="13">
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    <feature type="binding site" evidence="13">
        <location>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="612"/>
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        <ligand>
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    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="692"/>
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        <ligand>
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    <feature type="binding site" evidence="13">
        <location>
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        <ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="694"/>
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        <ligand>
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    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="829"/>
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        <ligand>
            <name>ATP</name>
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    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="835"/>
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        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="855"/>
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        <ligand>
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    <feature type="binding site" evidence="13">
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    <feature type="binding site" evidence="13">
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WormBase" id="H06H21.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PeptideAtlas" id="Q9TXV2"/>
        </source>
    </evidence>
    <sequence length="1314" mass="148756" checksum="D570F3B97F43C726" modified="2011-06-28" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2026-01-28" version="185" xmlns="https://uniprot.org/uniprot">
    <accession>Q9U2R6-2</accession>
    <name>NHR91_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Nuclear hormone receptor family member nhr-91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nhr-91</name>
        <name type="ORF">Y15E3A.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Dev. Biol." volume="266" first="399" last="416">
            <title>Expression and function of conserved nuclear receptor genes in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gissendanner C.R."/>
                <person name="Crossgrove K."/>
                <person name="Kraus K.A."/>
                <person name="Maina C.V."/>
                <person name="Sluder A.E."/>
            </authorList>
            <dbReference type="PubMed" id="14738886"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2003.10.014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9U2R6-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020168"/>
        </isoform>
        <isoform>
            <id>Q9U2R6-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379437.1">
        <property type="nucleotide sequence ID" value="NM_001392897.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y15E3A.1b">
        <property type="protein sequence ID" value="CE38001"/>
        <property type="gene ID" value="WBGene00003681"/>
        <property type="gene designation" value="nhr-91"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="310" mass="35408" checksum="DD02DF1CD1C4952A" modified="2001-10-01" version="2">MLTEAVREDRMPGGRNGNSIYSNYKQRRSIIRKTKDYVEEQERRPFQSLPSGKKLIKELVEMDCLDRLINLKGLRINPSANCDIAPACKRLTRIGDEIVEQLVEWTKTLPFFDELPVEAHTHLLTQRWAELVLLSAGYYACSVFTPDSPDTTEMIDETDEISFTNPQVNLRLLQNRLSLVLGKEIPLEHVAKEAGPLVTRFTTLLHSFSNLKVSPEAYVCIKAITLLHLSADSTLDRSIIDKVNTLQDHFVKTLQIHLHQPGEDAQTTSLAQILDWLPDLRNASSVLLHSKMFYVPFLLCKNPRRLVFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBZ5</accession>
    <name>U4PBZ5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">duo-3</name>
        <name evidence="11" type="ORF">CELE_Y106G6H.12</name>
        <name evidence="13" type="ORF">Y106G6H.12</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDH93265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293464.1">
        <property type="nucleotide sequence ID" value="NM_001306535.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBZ5"/>
    <dbReference type="SMR" id="U4PBZ5"/>
    <dbReference type="GeneID" id="172925"/>
    <dbReference type="AGR" id="WB:WBGene00001112"/>
    <dbReference type="CTD" id="172925"/>
    <dbReference type="WormBase" id="Y106G6H.12b">
        <property type="protein sequence ID" value="CE48920"/>
        <property type="gene ID" value="WBGene00001112"/>
        <property type="gene designation" value="duo-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813749at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001112">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBZ5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22755">
        <property type="entry name" value="OTU_CeDUB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02673">
        <property type="entry name" value="Peptidase_C19Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000291">
        <property type="entry name" value="Deubiquitylating with USP/UBP and OTU domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000032">
        <property type="entry name" value="Deubiquitylating with USP/UBP and OTU domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="147"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="10">
        <location>
            <begin position="507"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="633"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="661"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDH93265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="Y106G6H.12b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="U4PBZ5"/>
        </source>
    </evidence>
    <sequence length="769" mass="88324" checksum="2570E558C0BB6F76" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4PBZ7</accession>
    <name>U4PBZ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clip domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="ORF">C44B12.6</name>
        <name evidence="5" type="ORF">CELE_C44B12.6</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368315.1">
        <property type="nucleotide sequence ID" value="NM_001380032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PBZ7"/>
    <dbReference type="GeneID" id="183438"/>
    <dbReference type="AGR" id="WB:WBGene00016639"/>
    <dbReference type="CTD" id="183438"/>
    <dbReference type="WormBase" id="C44B12.6a">
        <property type="protein sequence ID" value="CE48507"/>
        <property type="gene ID" value="WBGene00016639"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152132_0_0_1"/>
    <dbReference type="OMA" id="AISEVEC"/>
    <dbReference type="OrthoDB" id="5802485at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016639">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PBZ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C44B12.6a"/>
        </source>
    </evidence>
    <sequence length="159" mass="18266" checksum="8ED8E78B5B223C58" modified="2013-12-11" version="1">MHEAFSRLINRRDEDMFSFFQPDSQIFLEYQPLHRHMLTPKSRDCSEPSIDKSSEVLPDQPLSERSICPYHHILNYDEKRIPAAISEVECSCPHVKVHGGIIHCEPMMYNMRVMLFDDSCDKYVERVQKVALACVPVFSNHISSGTHSHSLPTPPSTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEC2</accession>
    <name>U4PEC2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">eor-1</name>
        <name evidence="8" type="ORF">CELE_R11E3.6</name>
        <name evidence="10" type="ORF">R11E3.6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368235.1">
        <property type="nucleotide sequence ID" value="NM_001380208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEC2"/>
    <dbReference type="SMR" id="U4PEC2"/>
    <dbReference type="GeneID" id="177249"/>
    <dbReference type="AGR" id="WB:WBGene00001324"/>
    <dbReference type="CTD" id="177249"/>
    <dbReference type="WormBase" id="R11E3.6b">
        <property type="protein sequence ID" value="CE48689"/>
        <property type="gene ID" value="WBGene00001324"/>
        <property type="gene designation" value="eor-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014896_0_0_1"/>
    <dbReference type="OrthoDB" id="9978265at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001324">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEC2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002780">
        <property type="entry name" value="Protein CBR-EOR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002606">
        <property type="entry name" value="Zinc finger protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDH93069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="R11E3.6b"/>
        </source>
    </evidence>
    <sequence length="291" mass="32439" checksum="7F737BADD7E7363F" modified="2013-12-11" version="1">MAVRAHLCKICGRGFIEKSHLVRHERIHLEEKPFKCDQCEYASSRRDKLKEHIIKHHNSEVLTFQKTQRRKYKRQRMLAAASNIVNNPDALFRPITSDDAVSNWQATNDFSTYSPNPNDYGGPSTYGNPSSPQRAFSVVHPSQHQHHAQSPGCMSMMNVPLRDNHHQMQRQDSPGDSVGGGQGGGGGGGPEGSDNTHGVLMTPNLVMRSPHNRSAVQPQFNNLSTNSDPQQQQQQQQLRPFSLPTYGQMDLAQAAQLQQLQQQLQAAGLPPTGTPNNQDNSNNAWNPWNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEE3</accession>
    <name>U4PEE3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fln-1</name>
        <name evidence="6" type="ORF">CELE_Y66H1B.2</name>
        <name evidence="8" type="ORF">Y66H1B.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294362.1">
        <property type="nucleotide sequence ID" value="NM_001307433.3"/>
    </dbReference>
    <dbReference type="SMR" id="U4PEE3"/>
    <dbReference type="GeneID" id="176855"/>
    <dbReference type="AGR" id="WB:WBGene00022048"/>
    <dbReference type="CTD" id="176855"/>
    <dbReference type="WormBase" id="Y66H1B.2j">
        <property type="protein sequence ID" value="CE48963"/>
        <property type="gene ID" value="WBGene00022048"/>
        <property type="gene designation" value="fln-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022048">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEE3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21311">
        <property type="entry name" value="CH_dFLNA-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21230">
        <property type="entry name" value="CH_FLN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000140">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001719">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001876">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001886">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000006">
        <property type="entry name" value="Filamin-B isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000096">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="150"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="254"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="369"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="543"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="638"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="735"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="923"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1327"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1422"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1511"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1603"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1720"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1796"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1910"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1987"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2112"/>
            <end position="2206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH93090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y66H1B.2j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="U4PEE3"/>
        </source>
    </evidence>
    <sequence length="2206" mass="240760" checksum="3680398DAFDF4782" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEE8</accession>
    <name>U4PEE8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fln-1</name>
        <name evidence="6" type="ORF">CELE_Y66H1B.2</name>
        <name evidence="8" type="ORF">Y66H1B.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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        <source>
            <dbReference type="PeptideAtlas" id="V6CKJ6"/>
        </source>
    </evidence>
    <sequence length="2515" mass="285789" checksum="071F5601EBF4C8BE" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKK1</accession>
    <name>V6CKK1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C55C3.6</name>
        <name evidence="3" type="ORF">CELE_C55C3.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293810.1">
        <property type="nucleotide sequence ID" value="NM_001306881.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKK1"/>
    <dbReference type="GeneID" id="259887"/>
    <dbReference type="KEGG" id="cel:CELE_C55C3.6"/>
    <dbReference type="AGR" id="WB:WBGene00016956"/>
    <dbReference type="CTD" id="259887"/>
    <dbReference type="WormBase" id="C55C3.6b">
        <property type="protein sequence ID" value="CE49429"/>
        <property type="gene ID" value="WBGene00016956"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085836_0_0_1"/>
    <dbReference type="OrthoDB" id="5877392at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016956">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKK1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013153065" evidence="2">
        <location>
            <begin position="16"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDK13556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C55C3.6b"/>
        </source>
    </evidence>
    <sequence length="252" mass="27384" checksum="8A3DE501CD86AF14" modified="2014-02-19" version="1">MFIGLIMFVGFVVQCGKKKKEKNTSSKGQLLEQSTMVQPTAGAVAGKAAVNRQNPQMSEMQKSGIGNGAEQVEGKPKTPGNGKNGKANSKKQSKKTKSEKSQSSNKEGAPLKPMDPTPSDPNDDPLQAQLIVLKAEECNKMDVTIEDFGNPAIHDRVSRAAATDMIFDPKGIKYKGNVDDGKDKKVMEDVEKDILAACEKHDAKFSRNGKVVKTVESEKSKVAPADQRVKMKPEGCVLFETRELLSELFGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKK8</accession>
    <name>V6CKK8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">fkh-7</name>
        <name evidence="13" type="ORF">CELE_F26D12.1</name>
        <name evidence="15" type="ORF">F26D12.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293815.1">
        <property type="nucleotide sequence ID" value="NM_001306886.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKK8"/>
    <dbReference type="SMR" id="V6CKK8"/>
    <dbReference type="GeneID" id="177340"/>
    <dbReference type="AGR" id="WB:WBGene00001439"/>
    <dbReference type="CTD" id="177340"/>
    <dbReference type="WormBase" id="F26D12.1l">
        <property type="protein sequence ID" value="CE49334"/>
        <property type="gene ID" value="WBGene00001439"/>
        <property type="gene designation" value="fkh-7"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830876at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001439">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKK8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20065">
        <property type="entry name" value="FH_FOXP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047412">
        <property type="entry name" value="FH_FOXP1_P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032354">
        <property type="entry name" value="FOXP-CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16159">
        <property type="entry name" value="FOXP-CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="377"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="377"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDK13561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F26D12.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="V6CKK8"/>
        </source>
    </evidence>
    <sequence length="578" mass="63022" checksum="833E006B0E9E6328" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKL2</accession>
    <name>V6CKL2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_Y65B4A.7</name>
        <name evidence="6 8" type="ORF">Y65B4A.7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293248.1">
        <property type="nucleotide sequence ID" value="NM_001306319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKL2"/>
    <dbReference type="SMR" id="V6CKL2"/>
    <dbReference type="GeneID" id="190486"/>
    <dbReference type="KEGG" id="cel:CELE_Y65B4A.7"/>
    <dbReference type="AGR" id="WB:WBGene00022030"/>
    <dbReference type="CTD" id="190486"/>
    <dbReference type="WormBase" id="Y65B4A.7b">
        <property type="protein sequence ID" value="CE49283"/>
        <property type="gene ID" value="WBGene00022030"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133444_0_0_1"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022030">
        <property type="expression patterns" value="Expressed in material anatomical entity and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKL2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09396">
        <property type="entry name" value="LIM_DA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000172">
        <property type="entry name" value="Protein CBG11874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDK13566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y65B4A.7b"/>
        </source>
    </evidence>
    <sequence length="95" mass="10857" checksum="620A5029F1170CA4" modified="2014-02-19" version="1">MTPCYPMPAPYGNALRCADCHRAAKSPKCHACKLPTFERCVSAFNVHWHMACFKCKACRHPIKGQEYVVHQGCAYDEDCYHHTIQKIDMENDPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKL6</accession>
    <name>V6CKL6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">unc-77</name>
        <name evidence="27" type="ORF">C11D2.6</name>
        <name evidence="25" type="ORF">CELE_C11D2.6</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293819.1">
        <property type="nucleotide sequence ID" value="NM_001306890.3"/>
    </dbReference>
    <dbReference type="SMR" id="V6CKL6"/>
    <dbReference type="GeneID" id="177379"/>
    <dbReference type="AGR" id="WB:WBGene00006809"/>
    <dbReference type="CTD" id="177379"/>
    <dbReference type="WormBase" id="C11D2.6h">
        <property type="protein sequence ID" value="CE49180"/>
        <property type="gene ID" value="WBGene00006809"/>
        <property type="gene designation" value="unc-77"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006809">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKL6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000089">
        <property type="entry name" value="Four domain-type voltage-gated ion channel alpha-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000080">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000060">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000061">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000066">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000030">
        <property type="entry name" value="sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000032">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000034">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF2">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="864"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="909"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="944"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1006"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1120"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1201"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1233"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1273"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1307"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1345"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1430"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="369"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="870"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="1199"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1633"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1642"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="1658"/>
            <end position="1668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDK13571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="C11D2.6h"/>
        </source>
    </evidence>
    <sequence length="1772" mass="205587" checksum="478BF8CD8EF1370D" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>V6CKN5</accession>
    <name>V6CKN5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y34D9A.3</name>
        <name evidence="1 3" type="ORF">Y34D9A.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293257.1">
        <property type="nucleotide sequence ID" value="NM_001306328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CKN5"/>
    <dbReference type="GeneID" id="171684"/>
    <dbReference type="AGR" id="WB:WBGene00021329"/>
    <dbReference type="CTD" id="171684"/>
    <dbReference type="WormBase" id="Y34D9A.3f">
        <property type="protein sequence ID" value="CE49369"/>
        <property type="gene ID" value="WBGene00021329"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817237at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021329">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CKN5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052452">
        <property type="entry name" value="Ankyrin-MYND_dom_contain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24150">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24150:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDK13587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y34D9A.3f"/>
        </source>
    </evidence>
    <sequence length="707" mass="81795" checksum="6D1C14A72C74CB24" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BS43</accession>
    <name>A0A078BS43_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TSC22 domain family protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C30G4.4</name>
        <name evidence="2" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294813.1">
        <property type="nucleotide sequence ID" value="NM_001307884.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BS43"/>
    <dbReference type="SMR" id="A0A078BS43"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4m">
        <property type="protein sequence ID" value="CE50070"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BS43">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C30G4.4m"/>
        </source>
    </evidence>
    <sequence length="224" mass="24512" checksum="6844DE7B78DD7E95" modified="2014-10-29" version="1">MSSGGSRFKQSESPINMLITHREMKCDMKSEPSLKVVPVETRDPYFSPNGKHAIAKPTAAIKNIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKSVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BS47</accession>
    <name>A0A078BS47_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TSC22 domain family protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C30G4.4</name>
        <name evidence="2" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294818.1">
        <property type="nucleotide sequence ID" value="NM_001307889.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BS47"/>
    <dbReference type="SMR" id="A0A078BS47"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4r">
        <property type="protein sequence ID" value="CE50066"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BS47">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C30G4.4r"/>
        </source>
    </evidence>
    <sequence length="89" mass="10139" checksum="429633C8295E7733" modified="2014-10-29" version="1">MVAEANQSRRTKSVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BS59</accession>
    <name>A0A078BS59_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ntl-11</name>
        <name evidence="11" type="ORF">CELE_Y73F8A.25</name>
        <name evidence="13" type="ORF">Y73F8A.25</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294107.1">
        <property type="nucleotide sequence ID" value="NM_001307178.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BS59"/>
    <dbReference type="SMR" id="A0A078BS59"/>
    <dbReference type="PeptideAtlas" id="A0A078BS59"/>
    <dbReference type="GeneID" id="178432"/>
    <dbReference type="AGR" id="WB:WBGene00013530"/>
    <dbReference type="CTD" id="178432"/>
    <dbReference type="WormBase" id="Y73F8A.25e">
        <property type="protein sequence ID" value="CE50059"/>
        <property type="gene ID" value="WBGene00013530"/>
        <property type="gene designation" value="ntl-11"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013530">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BS59">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDX47474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="Y73F8A.25e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BS59"/>
        </source>
    </evidence>
    <sequence length="222" mass="24731" checksum="32975D097774FBF6" modified="2014-10-29" version="1">MMIQFVRTALITHPQYDRLLQASVLDENIISFIRTNVKFAGAFLVRNALSEQDTCLLFKRYMRLCEGVNSTVHSLETVLKLSKEFIEHDKLTQEHREVVLAFVRHTIRTCEGDRTVRLVAMLVKKLLRERVLNVEDIAADVKPFTLKYTDNRECTALYQSMINMQNGGGGGGQENMTTSTTTTTTTTKSSSPNSLSTTTTTTSHNPGASATTTTTTVSFALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BS63</accession>
    <name>A0A078BS63_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">InTestinal NeureXin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">itx-1</name>
        <name evidence="8" type="ORF">CELE_W03D8.6</name>
        <name evidence="10" type="ORF">W03D8.6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293382.1">
        <property type="nucleotide sequence ID" value="NM_001306453.2"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
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    <keyword evidence="5" id="KW-0732">Signal</keyword>
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    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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        <location>
            <begin position="17"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1428"/>
            <end position="1450"/>
        </location>
    </feature>
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        <location>
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            <end position="509"/>
        </location>
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        <location>
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            <end position="857"/>
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        <location>
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            <end position="1122"/>
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            <end position="1375"/>
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        <location>
            <begin position="1593"/>
            <end position="1642"/>
        </location>
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        <location>
            <begin position="499"/>
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        <location>
            <begin position="866"/>
            <end position="883"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
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            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDX47479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="W03D8.6c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BS63"/>
        </source>
    </evidence>
    <sequence length="1642" mass="182554" checksum="8287DF17321E9037" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BS67</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">CELE_Y40H7A.2</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditina</taxon>
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        </lineage>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 4">Bristol N2</strain>
        </source>
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    <reference evidence="2" key="2">
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                <person name="Waterston R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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    </dbReference>
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        <property type="protein sequence ID" value="CDX47485.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="CTD" id="189802"/>
    <dbReference type="WormBase" id="Y40H7A.2b">
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        <property type="gene ID" value="WBGene00012742"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y40H7A.2b"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y40H7A.3b"/>
        </source>
    </evidence>
    <sequence length="163" mass="18960" checksum="8438AE77945F9BB9" modified="2014-10-29" version="1">MRSMMSLGLNDQIQFDEEIQSITDYRCNIIGADMARQNATTQEKYAKMKGQLFVGNVPDTLKLYRMMIDSESKEVEILKIDIESSEHAALEPFLKNYFVCQILIEIHGLPAKQLEMLRKISRLGFRMFNFERNPSCTICCEYSFINEMCMSRYQVIPMVSLIT</sequence>
</entry>
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    <accession>A0A078BS85</accession>
    <name>A0A078BS85_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">jac-1</name>
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        <name evidence="11" type="ORF">Y105C5B.21</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294123.1">
        <property type="nucleotide sequence ID" value="NM_001307194.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BS85"/>
    <dbReference type="SMR" id="A0A078BS85"/>
    <dbReference type="GeneID" id="178451"/>
    <dbReference type="AGR" id="WB:WBGene00002175"/>
    <dbReference type="CTD" id="178451"/>
    <dbReference type="WormBase" id="Y105C5B.21e">
        <property type="protein sequence ID" value="CE50117"/>
        <property type="gene ID" value="WBGene00002175"/>
        <property type="gene designation" value="jac-1"/>
    </dbReference>
    <dbReference type="OMA" id="QFRVIAC"/>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002175">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000504">
        <property type="entry name" value="Bent, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000458">
        <property type="entry name" value="Juxtamembrane domain-associated catenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF27">
        <property type="entry name" value="ADHERENS JUNCTION PROTEIN P120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Fibronectin type-III" evidence="8">
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            <end position="518"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="530"/>
            <end position="624"/>
        </location>
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    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="733"/>
            <end position="766"/>
        </location>
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    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="1016"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="920"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1161"/>
            <end position="1256"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
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            <begin position="12"/>
            <end position="22"/>
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            <begin position="145"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1168"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1179"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDX47504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y105C5B.21e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BS85"/>
        </source>
    </evidence>
    <sequence length="1256" mass="138544" checksum="12B8DB5C7ABB0C47" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0M9JJ73</accession>
    <name>A0A0M9JJ73_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_K07E8.7</name>
        <name evidence="6 8" type="ORF">K07E8.7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CUR29982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309514.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0M9JJ73"/>
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    <dbReference type="AGR" id="WB:WBGene00019498"/>
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    <dbReference type="WormBase" id="K07E8.7b">
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        <property type="gene ID" value="WBGene00019498"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="CDD" id="cd02557">
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        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
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    </dbReference>
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        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
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            <end position="290"/>
        </location>
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    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="188"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUR29982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="K07E8.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0M9JJ73"/>
        </source>
    </evidence>
    <sequence length="421" mass="48887" checksum="AB4BBE1530E401A0" modified="2015-12-09" version="1">MSDTTDVPENQRKIEEKPENSSLKRKKFEDPNKKVDPLEELPMKVPFKIVDGVRHLAPYWACYRTRTKGRWIGRKMVEVFSGEFLSTNRNYAKIACKMGRIYVNGEQMTDVDYVMRNGDRVEHWAHRHEHPIRDLPIRVISETDDLFVVEKPPSLPVHTCGQYAIHTVLGQLRVNEGRTGLRVLHRLDRATSGVLLFAKNYETDLEFKTTLKQGEWSKEYICKVDGVFPDEEQVCEQPIGPLVISMGIQCVRPDGKDAKSRFRKLWSDGTQSVVQVHIETGRTHQIRVHSQFLGHPIAGDQIYNSAVWGPTKGKNADYQKSFDELCEDVRNTHKCENWHEKPNPEFEQRMEHLAADTTPITPEAPSLTLEQRPEFDEICQKCNVESKKVPENHFQLYLHCLKYETKKWSFKTEMPDWAVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0M9JJ78</accession>
    <name>A0A0M9JJ78_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CYtochrome P450 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cyp-33c6</name>
        <name evidence="9" type="synonym">cyp-33C6</name>
        <name evidence="9" type="ORF">CELE_F41B5.7</name>
        <name evidence="11" type="ORF">F41B5.7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CUR30028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368585.1">
        <property type="nucleotide sequence ID" value="NM_001380616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0M9JJ78"/>
    <dbReference type="SMR" id="A0A0M9JJ78"/>
    <dbReference type="GeneID" id="185591"/>
    <dbReference type="AGR" id="WB:WBGene00018264"/>
    <dbReference type="WormBase" id="F41B5.7b">
        <property type="protein sequence ID" value="CE51124"/>
        <property type="gene ID" value="WBGene00018264"/>
        <property type="gene designation" value="cyp-33C6"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018264">
        <property type="expression patterns" value="Expressed in adult organism"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0M9JJ78">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUR30028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F41B5.7b"/>
        </source>
    </evidence>
    <sequence length="460" mass="53054" checksum="F14D655CC756DE83" modified="2015-12-09" version="1">MGNILAVILEKPGYECFRRWTKQFGDVYTFWMGNTPYIIIGTYDLLKETYIRDGDTYKDKYPHPFNEQLRGGMYGIVESNGHLWSTHRKFALSTLRNFGLGKDLMQENILIEVEDIFRKFDAQLGKEQEIQVVLKNAIANVINQIIFGYRFDATNQDKLEKMRYLVEYQEKAFTTVKASIQAFAPRIGSILPGKSLDQLLNEFKDNFYTFFNAEIENHRRKIDVDSEESQDYAEAYLKEQRKHEARGEFELFSNTQFANTCLDLWLAGVSTTNTTVNWTICYVLNHPEVLQKMNEEFDQVVGSDRLVSMGDKNNLPYFNAVLNESQRCANIVTINLFHATTKDTVINGYPIKKGTGVIAQISTVMLDEKIFPEPYKFNPDRFIGENGKPIKIEQLIPFSIGKRQCPGEGLARMEIFLLVANLFNRYKISPFSEGFPNLEKNSVVEIFAKGLRVILTKRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0M9JJ80</accession>
    <name>A0A0M9JJ80_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein-like 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y45G12B.2</name>
        <name evidence="3 5" type="ORF">Y45G12B.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CUR30068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001303769.1">
        <property type="nucleotide sequence ID" value="NM_001316840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0M9JJ80"/>
    <dbReference type="PeptideAtlas" id="A0A0M9JJ80"/>
    <dbReference type="GeneID" id="178734"/>
    <dbReference type="AGR" id="WB:WBGene00021563"/>
    <dbReference type="CTD" id="178734"/>
    <dbReference type="WormBase" id="Y45G12B.2c">
        <property type="protein sequence ID" value="CE51096"/>
        <property type="gene ID" value="WBGene00021563"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1916590at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021563">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0M9JJ80">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUR30068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y45G12B.2c"/>
        </source>
    </evidence>
    <sequence length="132" mass="14825" checksum="10ACD8F14A35956E" modified="2015-12-09" version="1">MEDTASYSVSNNDVTFARKKNYGAESSSDTRPLLQLRDADNEENKYKRRPTMDWMRGLWRAKHGGSGVPQERASAKKIALFVIFLAVLALITIIMVMKRAGYSGEHSSDPLFDPMANPNIRVAVEDSRLPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0M9JJ82</accession>
    <name>A0A0M9JJ82_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F41B5.12</name>
        <name evidence="2 4" type="ORF">F41B5.12</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CUR30026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001303727.1">
        <property type="nucleotide sequence ID" value="NM_001316798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0M9JJ82"/>
    <dbReference type="GeneID" id="13211880"/>
    <dbReference type="AGR" id="WB:WBGene00202502"/>
    <dbReference type="CTD" id="13211880"/>
    <dbReference type="WormBase" id="F41B5.12b">
        <property type="protein sequence ID" value="CE45509"/>
        <property type="gene ID" value="WBGene00202502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00202502">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0M9JJ82">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003326">
        <property type="entry name" value="TRA-1_regulated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02343">
        <property type="entry name" value="TRA-1_regulated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUR30026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F41B5.12b"/>
        </source>
    </evidence>
    <sequence length="144" mass="15746" checksum="C718EE4F3D2DD18C" modified="2015-12-09" version="1">MPTTMAMESTTEKVCLDTKNSPCGKLENKFILNGVKVEYVERNGCTVPRCPNMLLPSVFFVNSKSEIPIIDPLKPSFTIRVLPPLKYAELEASSFTEYYGLSCEGSAWTISNYPHGTTTPTNGVAAGRDGSTDGKKSPIDFIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0M9JJ84</accession>
    <name>A0A0M9JJ84_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srh-38</name>
        <name evidence="4" type="ORF">C31B8.11</name>
        <name evidence="2" type="ORF">CELE_C31B8.11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CUR30016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001303717.1">
        <property type="nucleotide sequence ID" value="NM_001316788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0M9JJ84"/>
    <dbReference type="GeneID" id="191857"/>
    <dbReference type="AGR" id="WB:WBGene00005261"/>
    <dbReference type="CTD" id="191857"/>
    <dbReference type="WormBase" id="C31B8.11c">
        <property type="protein sequence ID" value="CE51134"/>
        <property type="gene ID" value="WBGene00005261"/>
        <property type="gene designation" value="srh-38"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5819164at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0M9JJ84">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019422">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47922">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47922:SF1">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10318">
        <property type="entry name" value="7TM_GPCR_Srh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUR30016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C31B8.11c"/>
        </source>
    </evidence>
    <sequence length="244" mass="28192" checksum="512C3025A50E2A31" modified="2015-12-09" version="1">MFTAFVTETSGLILFTSRVLLIVDLYRPRPSIQRRICEFLIYCVVFAFGMWAIPMIIWQLPDQKFAKLNVIKTHEFYPDCIWDSNVIAITSTDSTEEDVICVLIVANCVSIGFAIFISAKIAFYMLSRRMINQSEATKKMHKKFNERTILQAILYFTFCCVPFSVLYLTILLEVHIPGSTYFIDIFSENHPTACAVSLFLFYDPYQYYLMELLGIKLRQKISNASTILVEKVNTISRNSNIVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0M9JJ97</accession>
    <name>A0A0M9JJ97_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y19D10A.8</name>
        <name evidence="4 6" type="ORF">Y19D10A.8</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CUR30066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001303767.1">
        <property type="nucleotide sequence ID" value="NM_001316838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0M9JJ97"/>
    <dbReference type="SMR" id="A0A0M9JJ97"/>
    <dbReference type="PaxDb" id="6239-F56A4.10"/>
    <dbReference type="GeneID" id="189486"/>
    <dbReference type="KEGG" id="cel:CELE_Y19D10A.8"/>
    <dbReference type="AGR" id="WB:WBGene00021223"/>
    <dbReference type="CTD" id="189486"/>
    <dbReference type="WormBase" id="Y19D10A.8a">
        <property type="protein sequence ID" value="CE51086"/>
        <property type="gene ID" value="WBGene00021223"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021223">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF21">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="26"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUR30066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y19D10A.8a"/>
        </source>
    </evidence>
    <sequence length="458" mass="50706" checksum="332E83717511151B" modified="2015-12-09" version="1">MITGFEFPQVRKTSSFVFWNRTRIYVMVLTLICLTFMQMNTLTLNFTVICMDDIVEDFHMFHNSTETHWFERSTEKSLLFSGVAIGGLIGLVPSVPQISSIGLRNTQTISGFISGLGSFLFPLAVSVGFYTSFLCRVLQGIGAAVLFTAVGVVPGVWAPKSEANTFMSILACAFQLSNVICMPVSGLLCESAVGWRSIYYISGAITFVLYTVFWFTYTDDPKLHRNVSQKELRKISTGKVEKIKEPVPYFAVSTDPTVIISWISLFGGNMGFYVLCIYGPTYLREVLKFDVKETGFLTALPFILSAIAKFSAGRISDKLTGLSERARFVFFASIFQIGLVAGLVVMAFTTNRVIAQIAFNFAIVSSGLNIMGVVKCVQLRCLQHVHYTLTVMSFTAYASQFLSPTLVSIICPNYTNEQWKTFFLVISGLIVACNAGFPFLARSDAAGYTKKQEPTVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DR57</accession>
    <name>A0A3B1DR57_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_E02H4.2</name>
        <name evidence="2 4" type="ORF">E02H4.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1DR57"/>
    <dbReference type="PaxDb" id="6239-E02H4.2"/>
    <dbReference type="AGR" id="WB:WBGene00008460"/>
    <dbReference type="WormBase" id="E02H4.2b">
        <property type="protein sequence ID" value="CE52773"/>
        <property type="gene ID" value="WBGene00008460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008460">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VAY52609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="E02H4.2b"/>
        </source>
    </evidence>
    <sequence length="598" mass="66780" checksum="B4EBB5F183F8A35B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1DR76</accession>
    <name>A0A3B1DR76_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mec-2</name>
        <name evidence="7" type="ORF">CELE_F14D12.4</name>
        <name evidence="9" type="ORF">F14D12.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368717.1">
        <property type="nucleotide sequence ID" value="NM_001380977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1DR76"/>
    <dbReference type="SMR" id="A0A3B1DR76"/>
    <dbReference type="GeneID" id="180826"/>
    <dbReference type="AGR" id="WB:WBGene00003166"/>
    <dbReference type="CTD" id="180826"/>
    <dbReference type="WormBase" id="F14D12.4p">
        <property type="protein sequence ID" value="CE52703"/>
        <property type="gene ID" value="WBGene00003166"/>
        <property type="gene designation" value="mec-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003166">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1DR76">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03403">
        <property type="entry name" value="SPFH_stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="64"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VAY52619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F14D12.4p"/>
        </source>
    </evidence>
    <sequence length="424" mass="46225" checksum="1DC38F8F012B5EE6" modified="2018-12-05" version="1">MKPRETVATTSGTDSTPKTTILPAKKDYFHVEANIQNEFGVCGWILTILSYLLIFFTLPISACMCIKVVQEYERAVIFRLGRLMPGGAKGPGIFFIVPCIDTYRKVDLRVLSFEVPPQEILSKDSVTVAVDAVVYFRISNATISVTNVEDAARSTKLLAQTTLRNILGTKTLAEMLSDREAISHQMQTTLDEATEPWGVKVERVEVKDVRLPVQLQRAMAAEAEAAREARAKVIVAEGEQKASRALKEAAEVIAESPSALQLRYLQTLNSISAEKNSTIIFPFPIDLLSAFLQRTPPKVEEPPSLPKKIRSCCLYKYPDWVQGMVGSEGGGGHGHSHGGGGGGLGSSQVRAKGSIPSISSRFRPEHHNHQWPSAAPQHARSAVSLRSTADLSSKSVPNISESVGPRFTVWSTIASKQQTGRCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4SRQ8</accession>
    <name>A0A8S4SRQ8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Golgi pH regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">gphr-1</name>
        <name evidence="12" type="ORF">CELE_Y75B8A.16</name>
        <name evidence="14" type="ORF">Y75B8A.16</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Golgi pH regulator (TC 1.A.38) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAH2663955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001407532.1">
        <property type="nucleotide sequence ID" value="NM_001420558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4SRQ8"/>
    <dbReference type="SMR" id="A0A8S4SRQ8"/>
    <dbReference type="GeneID" id="176650"/>
    <dbReference type="AGR" id="WB:WBGene00013551"/>
    <dbReference type="CTD" id="176650"/>
    <dbReference type="WormBase" id="Y75B8A.16c">
        <property type="protein sequence ID" value="CE54552"/>
        <property type="gene ID" value="WBGene00013551"/>
        <property type="gene designation" value="gphr-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF5">
        <property type="entry name" value="GOLGI PH REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="11">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="10">
        <location>
            <begin position="150"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH2663955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="Y75B8A.16c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4SRQ8"/>
        </source>
    </evidence>
    <sequence length="329" mass="37884" checksum="735B11ADFD0F7F51" modified="2022-10-12" version="1">MLSPKHGIFTIEQVISRVGVVGVTIMAILSGFGAVNAPYCYMTFFTRPVEEFHVCQLEKKLAHTMDLIVLKKRKAARYELEKKRLSGEKTQKETTFFERFWDSFSEQSSGSTLASQIDRLKEEIIPLETLARFLFLDLVELRQMLNRVEFSKTFMGIYFNILGHFFSIYCIWKIFISFINIVFDRVGKVDPVTKTIEIGVHWMGIPLDISFWSQYISFFLVGVIAVTSVRGLLITMTKFFVSISNATSSLSNIIALLMAQIMGMYFVSSVLLMRMNVPEEYRTILTRILGDLKFNFYHRWFDVIFLISAVSSIVFLTLIHKSGSSMFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4SS65</accession>
    <name>A0A8S4SS65_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_T24E12.6</name>
        <name evidence="1 3" type="ORF">T24E12.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAH2659136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4SS65"/>
    <dbReference type="AGR" id="WB:WBGene00020775"/>
    <dbReference type="WormBase" id="T24E12.6c">
        <property type="protein sequence ID" value="CE54529"/>
        <property type="gene ID" value="WBGene00020775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH2659136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T24E12.6c"/>
        </source>
    </evidence>
    <sequence length="325" mass="37746" checksum="BBDBF8584EA29EB2" modified="2022-10-12" version="1">MPSVAQPSCSSRQNSKLLFQKASVDPSPTPGSNPLLENPILPEISSILPNLDPTLPDFNTTYSYLVNNHPPTQFLNLPAHPNPQILLTYPPNSIFPSLPLQLVPELVPTDLEAREPPSKVRCPNFELAEPQPKASDFGQNKVHYFNLEPSHEEFEQLKIVQNFVFSGEGFLLPDCDPVMKRSIIFTNAMNDHYKRSEDRVEAIYKKFEQRDAKMTYDQNAVNIKKRIHRRLLEYLQSGQHIERIMKCEEIVESSGVPVLSKDDRMFYADYQKKKNDVFRYLLDTEKAVLREKFEKMRSTIRRKEHYFCRKRSQLPANREEPLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRP1</accession>
    <name>C6KRP1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAM65 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y37A1A.4</name>
        <name evidence="4 6" type="ORF">Y37A1A.4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65471.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255771.2">
        <property type="nucleotide sequence ID" value="NM_001268842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRP1"/>
    <dbReference type="GeneID" id="4927018"/>
    <dbReference type="AGR" id="WB:WBGene00045063"/>
    <dbReference type="CTD" id="4927018"/>
    <dbReference type="WormBase" id="Y37A1A.4b">
        <property type="protein sequence ID" value="CE49981"/>
        <property type="gene ID" value="WBGene00045063"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9999654at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00045063">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRP1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031780">
        <property type="entry name" value="FAM65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026136">
        <property type="entry name" value="RIPOR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15829:SF13">
        <property type="entry name" value="FAM65 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15829">
        <property type="entry name" value="PROTEIN KINASE PKN/PRK1, EFFECTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15903">
        <property type="entry name" value="PL48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM65 N-terminal" evidence="3">
        <location>
            <begin position="129"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAZ65471.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y37A1A.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="C6KRP1"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112614" checksum="37FDD20BB21AA45F" modified="2014-09-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRP5</accession>
    <name>C6KRP5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="14">1.8.5.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Sulfide quinone oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">sqrd-1</name>
        <name evidence="18" type="ORF">CELE_F02H6.5</name>
        <name evidence="20" type="ORF">F02H6.5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol</text>
            <dbReference type="Rhea" id="RHEA:55156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.8.5.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:55157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10</text>
            <dbReference type="Rhea" id="RHEA:62608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:62609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate</text>
            <dbReference type="Rhea" id="RHEA:38359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:38360"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SQRD family.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.8" evidence="14"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255799.1">
        <property type="nucleotide sequence ID" value="NM_001268870.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRP5"/>
    <dbReference type="SMR" id="C6KRP5"/>
    <dbReference type="PeptideAtlas" id="C6KRP5"/>
    <dbReference type="GeneID" id="178374"/>
    <dbReference type="AGR" id="WB:WBGene00008538"/>
    <dbReference type="CTD" id="178374"/>
    <dbReference type="WormBase" id="F02H6.5b">
        <property type="protein sequence ID" value="CE43813"/>
        <property type="gene ID" value="WBGene00008538"/>
        <property type="gene designation" value="sqrd-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008538">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRP5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106436">
        <property type="term" value="F:glutathione-dependent sulfide quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000584">
        <property type="entry name" value="Sulfide Quinone oxidoReDuctase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="17">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAZ65483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="F02H6.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PeptideAtlas" id="C6KRP5"/>
        </source>
    </evidence>
    <sequence length="422" mass="46994" checksum="690923EEB96681FA" modified="2009-09-01" version="1">MRTSTVVYGKHFKLLVVGGGAGGLGAASKFARKLPRGSVGIIEPREDHYYQPGFTLVGGGLMSLEANRGKQKDLIPKNATWIQDKVQKFEPAKNSVKLRGGDEITYDYMVIAMGVQLRYDMIKGAKEALDTPGVCSNYSPFYVEKHYKEAMNFKGGNALYTFPNTPIKCAGAPQKACYITDSILRQRGVRDQAHMIYATSLKRLFGIESYLKSLEKVARDKEIDVRTRRNLIEVNTNDRIATFELLDEEAKPTGKTEQIEYSLLHIGPPCSTPEALRNSAFVDKTGFMDVDGGSLQSKKYPNVFGVGDCMNTPNAKTAAAVSSHLKTIEKNLTQVMQGNRPCMQYDGYASCPLVVSTNRVILAEFGPRGAMETTPFDQSKPTYWAYLMKRYFMPALYWNGLIKGYWNGPATLRNCTRLVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRP6</accession>
    <name>C6KRP6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="14">1.8.5.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Sulfide quinone oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">sqrd-1</name>
        <name evidence="17" type="ORF">CELE_F02H6.5</name>
        <name evidence="19" type="ORF">F02H6.5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol</text>
            <dbReference type="Rhea" id="RHEA:55156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.8.5.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:55157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10</text>
            <dbReference type="Rhea" id="RHEA:62608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:62609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate</text>
            <dbReference type="Rhea" id="RHEA:38359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:38360"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SQRD family.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.8" evidence="14"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255800.1">
        <property type="nucleotide sequence ID" value="NM_001268871.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRP6"/>
    <dbReference type="SMR" id="C6KRP6"/>
    <dbReference type="PeptideAtlas" id="C6KRP6"/>
    <dbReference type="GeneID" id="178374"/>
    <dbReference type="AGR" id="WB:WBGene00008538"/>
    <dbReference type="CTD" id="178374"/>
    <dbReference type="WormBase" id="F02H6.5c">
        <property type="protein sequence ID" value="CE43910"/>
        <property type="gene ID" value="WBGene00008538"/>
        <property type="gene designation" value="sqrd-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008538">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRP6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106436">
        <property type="term" value="F:glutathione-dependent sulfide quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000028">
        <property type="entry name" value="Pyridine nucleotide-disulfide oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000584">
        <property type="entry name" value="Sulfide Quinone oxidoReDuctase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAZ65484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="F02H6.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="C6KRP6"/>
        </source>
    </evidence>
    <sequence length="361" mass="40637" checksum="92E3B842F63F69A1" modified="2009-09-01" version="1">MSLEANRGKQKDLIPKNATWIQDKVQKFEPAKNSVKLRGGDEITYDYMVIAMGVQLRYDMIKGAKEALDTPGVCSNYSPFYVEKHYKEAMNFKGGNALYTFPNTPIKCAGAPQKACYITDSILRQRGVRDQAHMIYATSLKRLFGIESYLKSLEKVARDKEIDVRTRRNLIEVNTNDRIATFELLDEEAKPTGKTEQIEYSLLHIGPPCSTPEALRNSAFVDKTGFMDVDGGSLQSKKYPNVFGVGDCMNTPNAKTAAAVSSHLKTIEKNLTQVMQGNRPCMQYDGYASCPLVVSTNRVILAEFGPRGAMETTPFDQSKPTYWAYLMKRYFMPALYWNGLIKGYWNGPATLRNCTRLVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRQ3</accession>
    <name>C6KRQ3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuropeptide-Like Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nlp-56</name>
        <name evidence="2" type="ORF">CELE_Y57G11C.45</name>
        <name evidence="4" type="ORF">Y57G11C.45</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255833.1">
        <property type="nucleotide sequence ID" value="NM_001268904.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRQ3"/>
    <dbReference type="PeptideAtlas" id="C6KRQ3"/>
    <dbReference type="GeneID" id="3565782"/>
    <dbReference type="KEGG" id="cel:CELE_Y57G11C.45"/>
    <dbReference type="AGR" id="WB:WBGene00013334"/>
    <dbReference type="CTD" id="3565782"/>
    <dbReference type="WormBase" id="Y57G11C.45b">
        <property type="protein sequence ID" value="CE43889"/>
        <property type="gene ID" value="WBGene00013334"/>
        <property type="gene designation" value="nlp-56"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2212344_0_0_1"/>
    <dbReference type="OMA" id="GYACRFK"/>
    <dbReference type="OrthoDB" id="5849065at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013334">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRQ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002967956" evidence="1">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAZ65544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y57G11C.45b"/>
        </source>
    </evidence>
    <sequence length="114" mass="12885" checksum="AFC5CB3CA475F2B6" modified="2009-09-01" version="1">MPSPSSLLGSLLLVCAVLTITSRASSIMTDDVEPPQLLTRQLRSFPYSVSFYRMLGHDRQLRPYYGVNDEVAALIDSMNSDNVANEDVFPTRPRRSDGLRGYACRFKFCRIYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>D7UU24</accession>
    <name>D7UU24_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Polycystin cation channel PKD1/PKD2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">cup-5</name>
        <name evidence="17" type="ORF">CELE_R13A5.1</name>
        <name evidence="19" type="ORF">R13A5.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370401.1">
        <property type="nucleotide sequence ID" value="NM_001382919.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7UU24"/>
    <dbReference type="SMR" id="D7UU24"/>
    <dbReference type="PeptideAtlas" id="D7UU24"/>
    <dbReference type="GeneID" id="176074"/>
    <dbReference type="AGR" id="WB:WBGene00000846"/>
    <dbReference type="CTD" id="176074"/>
    <dbReference type="WormBase" id="R13A5.1a">
        <property type="protein sequence ID" value="CE45023"/>
        <property type="gene ID" value="WBGene00000846"/>
        <property type="gene designation" value="cup-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020945_1_1_1"/>
    <dbReference type="OrthoDB" id="263481at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000846">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7UU24">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010877">
        <property type="term" value="P:lipid transport involved in lipid storage"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd21050">
        <property type="entry name" value="ELD_TRPML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000207">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049134">
        <property type="entry name" value="MCLN_ECD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF7">
        <property type="entry name" value="SD02261P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21381">
        <property type="entry name" value="MCLN_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Mucolipin extracytosolic" evidence="16">
        <location>
            <begin position="99"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="15">
        <location>
            <begin position="386"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCD63610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="R13A5.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="D7UU24"/>
        </source>
    </evidence>
    <sequence length="607" mass="69475" checksum="F11F9F4894AAE1C2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>D8FRP8</accession>
    <name>D8FRP8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">emb-4</name>
        <name evidence="3" type="ORF">CELE_Y80D3A.2</name>
        <name evidence="5" type="ORF">Y80D3A.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO26656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256832.1">
        <property type="nucleotide sequence ID" value="NM_001269903.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D8FRP8"/>
    <dbReference type="SMR" id="D8FRP8"/>
    <dbReference type="PeptideAtlas" id="D8FRP8"/>
    <dbReference type="GeneID" id="180232"/>
    <dbReference type="AGR" id="WB:WBGene00001258"/>
    <dbReference type="CTD" id="180232"/>
    <dbReference type="WormBase" id="Y80D3A.2b">
        <property type="protein sequence ID" value="CE45135"/>
        <property type="gene ID" value="WBGene00001258"/>
        <property type="gene designation" value="emb-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001195_0_0_1"/>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001258">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D8FRP8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBO26656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y80D3A.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D8FRP8"/>
        </source>
    </evidence>
    <sequence length="252" mass="29233" checksum="1CD67CCB17D2E6F2" modified="2010-10-05" version="1">MRILGYPAEKISILTTYNGQAQLIRDVFQRRCDTNPLIGMPAKVSTVDKYQGQQNDFIILSLVKTRNIGHIRDVRRLVVALSRARLGLYVLGRSKVFMDCLELTPAMRIFAKYPRKLVILPFEAHPTIRKWNERSKDGEPMEIQDTLHMTHFVHEFYMSNLPAMRDAYEQAMNEYMESQRLLNPPIDETQMDVETEHEKKHREAMERKKKQEMDDKKEADIHFEDMDHEMQEPAATAAPAPGAPAVEEPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>D8FRP9</accession>
    <name>D8FRP9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA_12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">emb-4</name>
        <name evidence="2" type="ORF">CELE_Y80D3A.2</name>
        <name evidence="4" type="ORF">Y80D3A.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO26657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256833.1">
        <property type="nucleotide sequence ID" value="NM_001269904.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D8FRP9"/>
    <dbReference type="SMR" id="D8FRP9"/>
    <dbReference type="PeptideAtlas" id="D8FRP9"/>
    <dbReference type="GeneID" id="180232"/>
    <dbReference type="AGR" id="WB:WBGene00001258"/>
    <dbReference type="CTD" id="180232"/>
    <dbReference type="WormBase" id="Y80D3A.2c">
        <property type="protein sequence ID" value="CE45156"/>
        <property type="gene ID" value="WBGene00001258"/>
        <property type="gene designation" value="emb-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001195_0_0_1"/>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001258">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D8FRP9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBO26657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y80D3A.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="D8FRP9"/>
        </source>
    </evidence>
    <sequence length="104" mass="12156" checksum="18A36A9CDFBD0867" modified="2010-10-05" version="1">MTHFVHEFYMSNLPAMRDAYEQAMNEYMESQRLLNPPIDETQMDVETEHEKKHREAMERKKKQEMDDKKEADIHFEDMDHEMQEPAATAAPAPGAPAVEEPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>D8FRQ0</accession>
    <name>D8FRQ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">dcs-1</name>
        <name evidence="1" type="ORF">CELE_Y113G7A.9</name>
        <name evidence="3" type="ORF">Y113G7A.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO26090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001364670.1">
        <property type="nucleotide sequence ID" value="NM_001377611.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D8FRQ0"/>
    <dbReference type="SMR" id="D8FRQ0"/>
    <dbReference type="PeptideAtlas" id="D8FRQ0"/>
    <dbReference type="GeneID" id="180315"/>
    <dbReference type="AGR" id="WB:WBGene00000940"/>
    <dbReference type="CTD" id="180315"/>
    <dbReference type="WormBase" id="Y113G7A.9b">
        <property type="protein sequence ID" value="CE45165"/>
        <property type="gene ID" value="WBGene00000940"/>
        <property type="gene designation" value="dcs-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041045_2_0_1"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000940">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D8FRQ0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047627">
        <property type="term" value="F:adenylylsulfatase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004780">
        <property type="term" value="F:sulfate adenylyltransferase (ADP) activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009150">
        <property type="term" value="P:purine ribonucleotide metabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000060">
        <property type="entry name" value="M7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBO26090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y113G7A.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="D8FRQ0"/>
        </source>
    </evidence>
    <sequence length="98" mass="11649" checksum="862097AA63C0F102" modified="2010-10-05" version="1">MLYNMRDKSLEAINQKYGLKTDQIKCYFHYQPSFYHLHVHFINLKYDAPASTTMSAILLDDVINNLELNPEHYKKSTLTFTRKNGDKLMEMFREALKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-05-14" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>G5EE86-2</accession>
    <name>TTX3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform b of LIM/homeobox protein ttx-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Abnormal thermotaxis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ttx-3</name>
        <name type="ORF">C40H5.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1997" name="Neuron" volume="19" first="345" last="357">
            <title>Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene.</title>
            <authorList>
                <person name="Hobert O."/>
                <person name="Mori I."/>
                <person name="Yamashita Y."/>
                <person name="Honda H."/>
                <person name="Ohshima Y."/>
                <person name="Liu Y."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="9292724"/>
            <dbReference type="DOI" id="10.1016/S0896-6273(00)80944-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="6">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2001" name="Development" volume="128" first="1951" last="1969">
            <title>A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans.</title>
            <authorList>
                <person name="Altun-Gultekin Z."/>
                <person name="Andachi Y."/>
                <person name="Tsalik E.L."/>
                <person name="Pilgrim D."/>
                <person name="Kohara Y."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="11493519"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PHE-340</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Dev. Cell" volume="6" first="757" last="770">
            <title>Genomic cis-regulatory architecture and trans-acting regulators of a single interneuron-specific gene battery in C. elegans.</title>
            <authorList>
                <person name="Wenick A.S."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="15177025"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2004.05.004"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="5" key="5">
        <citation type="journal article" date="2005" name="Science" volume="309" first="787" last="790">
            <title>An interneuronal chemoreceptor required for olfactory imprinting in C. elegans.</title>
            <authorList>
                <person name="Remy J.J."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="16051801"/>
            <dbReference type="DOI" id="10.1126/science.1114209"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Dev. Cell" volume="16" first="563" last="575">
            <title>Linking asymmetric cell division to the terminal differentiation program of postmitotic neurons in C. elegans.</title>
            <authorList>
                <person name="Bertrand V."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="19386265"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2009.02.011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="5" key="7">
        <citation type="journal article" date="2010" name="Mech. Ageing Dev." volume="131" first="732" last="738">
            <title>Regulation of longevity by genes required for the functions of AIY interneuron in nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shen L."/>
                <person name="Hu Y."/>
                <person name="Cai T."/>
                <person name="Lin X."/>
                <person name="Wang D."/>
            </authorList>
            <dbReference type="PubMed" id="21055415"/>
            <dbReference type="DOI" id="10.1016/j.mad.2010.10.005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="1">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="journal article" date="2014" name="Development" volume="141" first="422" last="435">
            <title>The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.</title>
            <authorList>
                <person name="Zhang F."/>
                <person name="Bhattacharya A."/>
                <person name="Nelson J.C."/>
                <person name="Abe N."/>
                <person name="Gordon P."/>
                <person name="Lloret-Fernandez C."/>
                <person name="Maicas M."/>
                <person name="Flames N."/>
                <person name="Mann R.S."/>
                <person name="Colon-Ramos D.A."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="24353061"/>
            <dbReference type="DOI" id="10.1242/dev.099721"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EE86-1</id>
            <name evidence="2 3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EE86-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_054579"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001257169.1">
        <property type="nucleotide sequence ID" value="NM_001270240.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C40H5.5b">
        <property type="protein sequence ID" value="CE43132"/>
        <property type="gene ID" value="WBGene00006654"/>
        <property type="gene designation" value="ttx-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="21055415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="9292724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="9292724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="AAB97099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="CAB03956.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C40H5.5a"/>
        </source>
    </evidence>
    <sequence length="381" mass="42524" checksum="69B15E00031D00B6" modified="2011-12-14" version="1">MLTNSSSKETIATHVVTNSVPSAFQFDWSSHFKEEYDLVEKLNSPQYTNLTSISPSSSTDSNNLILRQIQIPKIEPALLNQCCLCTFAIVDKEISVVDGKYYHNNCLRCQMCDIPFEYSDKCYVRDGVFLCRADHAKRYQKCCRKCEIPLNREDMVMKAKEMIFHHACFVCFICGIKLNPGDYYTMSPQGHLYCHAHYNAVRSTVLCEEAAVATVPAVVAPPPPPPTTTTAPPPAAPEQPPREASTEAEASTDEDGNGSGSQRSKRMRTSFKHHQLRAMKTYFALNHNPDAKDLKQLAAKTNLTKRVLQVWFQNARAKYRRELHDGGRSSSPLCVSAPLASMDMNPPLSSSSSGHSTDGYQLNTPPLSSEIYSPNSNYTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYY0</accession>
    <name>H2KYY0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BURP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C23H5.8</name>
        <name evidence="2" type="ORF">CELE_C23H5.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD65347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379710.1">
        <property type="nucleotide sequence ID" value="NM_001392263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYY0"/>
    <dbReference type="SMR" id="H2KYY0"/>
    <dbReference type="PeptideAtlas" id="H2KYY0"/>
    <dbReference type="GeneID" id="177007"/>
    <dbReference type="AGR" id="WB:WBGene00016027"/>
    <dbReference type="CTD" id="177007"/>
    <dbReference type="WormBase" id="C23H5.8b">
        <property type="protein sequence ID" value="CE17441"/>
        <property type="gene ID" value="WBGene00016027"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5824843at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016027">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYY0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564287" evidence="1">
        <location>
            <begin position="24"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C23H5.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYY0"/>
        </source>
    </evidence>
    <sequence length="162" mass="17392" checksum="812326B13AE6594E" modified="2012-03-21" version="1">MANFAYLRLYLTIILSFAVQTSGNIGKCVLSSAPPSWLSTNGTGILEYATAGHPTNGTSFCIEGNHDQKTAHVAYHIDLGSEVLAPESVEHSFSENLGSQNGCVNNNTGVVYCFAICLNETLQNMVIESALKSNQPSVVAQDIQKTTQLDWAITVLQVGQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYZ6</accession>
    <name>H2KYZ6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">frm-4</name>
        <name evidence="6" type="ORF">C24A11.8</name>
        <name evidence="4" type="ORF">CELE_C24A11.8</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD65426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491586.1">
        <property type="nucleotide sequence ID" value="NM_059185.8"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYZ6"/>
    <dbReference type="SMR" id="H2KYZ6"/>
    <dbReference type="PeptideAtlas" id="H2KYZ6"/>
    <dbReference type="GeneID" id="172189"/>
    <dbReference type="AGR" id="WB:WBGene00001491"/>
    <dbReference type="CTD" id="172189"/>
    <dbReference type="WormBase" id="C24A11.8a">
        <property type="protein sequence ID" value="CE19698"/>
        <property type="gene ID" value="WBGene00001491"/>
        <property type="gene designation" value="frm-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6266673at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001491">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYZ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000561">
        <property type="entry name" value="FERM domain (Protein4.1-ezrin-radixin-moesin) family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000006">
        <property type="entry name" value="FERM domain-containing protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF32">
        <property type="entry name" value="FI22325P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="3">
        <location>
            <begin position="28"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD65426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C24A11.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYZ6"/>
        </source>
    </evidence>
    <sequence length="635" mass="71758" checksum="FAAD332B67D1131E" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYZ9</accession>
    <name>H2KYZ9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">17-beta-hydroxysteroid dehydrogenase type 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">dhs-2</name>
        <name evidence="2" type="ORF">CELE_F55A12.4</name>
        <name evidence="4" type="ORF">F55A12.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD65439.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309486.1">
        <property type="nucleotide sequence ID" value="NM_001322672.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYZ9"/>
    <dbReference type="SMR" id="H2KYZ9"/>
    <dbReference type="PeptideAtlas" id="H2KYZ9"/>
    <dbReference type="GeneID" id="172183"/>
    <dbReference type="KEGG" id="cel:CELE_F55A12.4"/>
    <dbReference type="AGR" id="WB:WBGene00000966"/>
    <dbReference type="CTD" id="172183"/>
    <dbReference type="WormBase" id="F55A12.4b">
        <property type="protein sequence ID" value="CE51265"/>
        <property type="gene ID" value="WBGene00000966"/>
        <property type="gene designation" value="dhs-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000966">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYZ9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF7">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65439.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F55A12.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYZ9"/>
        </source>
    </evidence>
    <sequence length="176" mass="19704" checksum="68D9A951996479BB" modified="2016-05-11" version="2">MAVKKLLKKARGRVVTVASICARVGLPGLGPYSVSKYGVSAYCDVIRQELRPFGISVHVLEPGFFNTPLINREKIDAEILEAWKHAPNEVKQEYGEKFFNDARESTHLFLNSVASSQISLVVDAYFHAITSKHPRSRYQIGWDSILLFIPFSYLPTGLQDYIFAAAGLFLPKPACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZA5</accession>
    <name>H2KZA5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF2846 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_R148.3</name>
        <name evidence="6 8" type="ORF">R148.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="H2KZA5"/>
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        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="H2KZA5"/>
    <dbReference type="AGR" id="WB:WBGene00020102"/>
    <dbReference type="WormBase" id="R148.3a">
        <property type="protein sequence ID" value="CE28640"/>
        <property type="gene ID" value="WBGene00020102"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857916at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020102">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZA5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050308">
        <property type="entry name" value="MukB/SMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42963">
        <property type="entry name" value="CHROMOSOME PARTITION PROTEIN MUKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42963:SF1">
        <property type="entry name" value="DUF4476 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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            <begin position="1"/>
            <end position="22"/>
        </location>
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            <begin position="23"/>
            <end position="1115"/>
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            <begin position="986"/>
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            <begin position="541"/>
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        <location>
            <begin position="767"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
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        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
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        <location>
            <begin position="212"/>
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            <begin position="276"/>
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            <begin position="287"/>
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            <begin position="425"/>
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            <begin position="1041"/>
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            <begin position="1086"/>
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            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Coils"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD67212.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="R148.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZA5"/>
        </source>
    </evidence>
    <sequence length="1115" mass="123023" checksum="8B450F42B6F1F0CF" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">MARVEL domain-containing protein</fullName>
        </submittedName>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="H2KZA8"/>
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        <property type="gene ID" value="WBGene00020103"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CCE67221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R148.4b"/>
        </source>
    </evidence>
    <sequence length="128" mass="14769" checksum="33659387BF6B5665" modified="2012-03-21" version="1">MSKEANFSFYGALPSFKPTRHCCGIVENSVLYLLLTALTTLQLIVFIVIFMHPELRNMLNLNPNLKQNQDILLLILTAMSSIWLLTVLFSFVGFMKKITYSHLPLIATEVEFEKFENFNREIRIPGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
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    </gene>
    <organism evidence="3 4">
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCJ09390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001276826.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I7LHV5"/>
    <dbReference type="SMR" id="I7LHV5"/>
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    <dbReference type="AGR" id="WB:WBGene00007900"/>
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    <dbReference type="WormBase" id="C33D9.6b">
        <property type="protein sequence ID" value="CE47706"/>
        <property type="gene ID" value="WBGene00007900"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562888_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007900">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="I7LHV5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="166"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCJ09390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C33D9.6b"/>
        </source>
    </evidence>
    <sequence length="219" mass="25505" checksum="EBCF9A23EC047C13" modified="2012-10-03" version="1">MAQHRLELEAQAKMIKTLEAELSKRQEINAEQIERLIEERNSEIKNLIREQSKEIHEKNVKIAKFEIKDYANIFRQISKNIFTNKEAPGPSGRPKKRRMVDDPEDLFHNYEDLDDAKFLELAKIIETTKKDVTTLINTEGPSEDVSGNFMEAKKIHGALAQLKEKDQTVSDLKQKTNQNNKRVDQEDPIEEYEYDYNDESDGESVKSETSSWDQIDDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>I7LHV8</accession>
    <name>I7LHV8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">fbn-1</name>
        <name evidence="11" type="ORF">CELE_ZK783.1</name>
        <name evidence="13" type="ORF">ZK783.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCJ09402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001276783.3"/>
    </dbReference>
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    <dbReference type="AGR" id="WB:WBGene00022816"/>
    <dbReference type="CTD" id="176076"/>
    <dbReference type="WormBase" id="ZK783.1b">
        <property type="protein sequence ID" value="CE47727"/>
        <property type="gene ID" value="WBGene00022816"/>
        <property type="gene designation" value="fbn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022816">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="I7LHV8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000555">
        <property type="entry name" value="Dumpy, isoform I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    <sequence length="2756" mass="289396" checksum="2C984AD5355F275E" modified="2012-10-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>I7LHV9</accession>
    <name>I7LHV9_CAEEL</name>
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        <submittedName>
            <fullName evidence="11">EGF-like domain-containing protein</fullName>
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        <name evidence="11 13" type="primary">fbn-1</name>
        <name evidence="11" type="ORF">CELE_ZK783.1</name>
        <name evidence="13" type="ORF">ZK783.1</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">Bristol N2</strain>
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        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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            <title>Cyclin E and CDK2 repress the terminal differentiation of quiescent cells after asymmetric division in C. elegans.</title>
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                <person name="Takeshita H."/>
                <person name="Sawa H."/>
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            <title>Translational repression of cyclin E prevents precocious mitosis and embryonic gene activation during C. elegans meiosis.</title>
            <authorList>
                <person name="Biedermann B."/>
                <person name="Wright J."/>
                <person name="Senften M."/>
                <person name="Kalchhauser I."/>
                <person name="Sarathy G."/>
                <person name="Lee M.H."/>
                <person name="Ciosk R."/>
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        <scope>DEVELOPMENTAL STAGE</scope>
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    <reference key="8">
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            <title>C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis.</title>
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                <person name="Inoue T."/>
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            <title>Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline.</title>
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                <person name="Vought V.E."/>
                <person name="Hanazawa M."/>
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                <person name="Verheyden J.M."/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1999" name="Genome Res." volume="9" first="103" last="120">
            <title>The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes.</title>
            <authorList>
                <person name="Sluder A.E."/>
                <person name="Mathews S.W."/>
                <person name="Hough D."/>
                <person name="Yin V.P."/>
                <person name="Maina C.V."/>
            </authorList>
            <dbReference type="PubMed" id="10022975"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 148-435 (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="0" last="0">
            <title>NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling.</title>
            <authorList>
                <person name="Rajan M."/>
                <person name="Anderson C.P."/>
                <person name="Rindler P.M."/>
                <person name="Romney S.J."/>
                <person name="Ferreira Dos Santos M.C."/>
                <person name="Gertz J."/>
                <person name="Leibold E.A."/>
            </authorList>
            <dbReference type="PubMed" id="31532389"/>
            <dbReference type="DOI" id="10.7554/elife.44674"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-33 AND 49-TRP--SER-435</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O02151-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O02151-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_007344"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741861.2">
        <property type="nucleotide sequence ID" value="NM_171743.6"/>
    </dbReference>
    <dbReference type="WormBase" id="T01B10.4b">
        <property type="protein sequence ID" value="CE33819"/>
        <property type="gene ID" value="WBGene00003613"/>
        <property type="gene designation" value="nhr-14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="434" mass="48530" checksum="D633A0F96D5CDACC" modified="2004-03-01" version="3">MDFLISTSLSESTSTSADFCVVCGDKAIGKHYGAVACNGCKGFFRRSVWQNLQYTCRFNKQCNIDKDHRNACRYCRFQKCLADGMKPEAIQNERDRIGSTKRRKRSGANSENNSDSEGTPSPKIEVMGNSVSRKLIEMLLDIEHRLASNQSMNALLRDESEMKNSRQRAVNYLIGWTNMLHPLPEVPLADKVLLLKKFSSAFTLLGTLQRSMALPHFVLPNDQVLSISASHPPELFEALTRIIDELLTPLRRLRTDHAEFSCLKALLLLNPDVVGISNNTRERIREARDALLKTLFAYMSNTQNSIDASLRVSSLLMIIPSLISVSSSIMEFPALSDLFGLGDVIKRDTISPKIETPPLEMKPMMPKIAQPPVTSAPTVPTNIMMNKDLISQIMNNPQLFPLLPMPQTASPPMSFMGQSYNRNSDVIFSQCPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-07-01" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>O02361</accession>
    <name>O02361_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CUB_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F35E12.9</name>
        <name evidence="2 4" type="ORF">F35E12.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB04276.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21770">
        <property type="entry name" value="T21770"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023881.1">
        <property type="nucleotide sequence ID" value="NM_001028710.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O02361"/>
    <dbReference type="GeneID" id="179867"/>
    <dbReference type="KEGG" id="cel:CELE_F35E12.9"/>
    <dbReference type="UCSC" id="F35E12.9b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009433"/>
    <dbReference type="CTD" id="179867"/>
    <dbReference type="WormBase" id="F35E12.9a">
        <property type="protein sequence ID" value="CE32404"/>
        <property type="gene ID" value="WBGene00009433"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1267917_0_0_1"/>
    <dbReference type="OrthoDB" id="5791243at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009433">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O02361">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21447:SF7">
        <property type="entry name" value="CUB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21447">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004156538" evidence="1">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB04276.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F35E12.9a"/>
        </source>
    </evidence>
    <sequence length="218" mass="24136" checksum="D1129CB70EF9A253" modified="2003-03-01" version="2">MLKLVLQLAFLVCSAHGVAFMEAYKQTIKKTGEYFPLSLVTGISYYTITSDNPNEKVVLSYAMRVGVNEDKLLAYYYVYDGDNINNATMIGNLDTIGGKITVSSGRSVTIVNFYGGTKSNSYALGNDASTVQGYDKYTVLMTSKGTTASGNMTSLATNGGLYTFICVDCSTFYYTQLRFDSMTPVSNRAYVTFQGMTPTHKKEKLIKYESVLLNWHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>O44137</accession>
    <name>O44137_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C50A2.3</name>
        <name evidence="2" type="ORF">CELE_C50A2.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD67236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T32505">
        <property type="entry name" value="T32505"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367653.1">
        <property type="nucleotide sequence ID" value="NM_001380033.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O44137"/>
    <dbReference type="SMR" id="O44137"/>
    <dbReference type="GeneID" id="183630"/>
    <dbReference type="UCSC" id="C50A2.3">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016797"/>
    <dbReference type="CTD" id="183630"/>
    <dbReference type="WormBase" id="C50A2.3a">
        <property type="protein sequence ID" value="CE17581"/>
        <property type="gene ID" value="WBGene00016797"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1410041_0_0_1"/>
    <dbReference type="OrthoDB" id="5816130at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016797">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O44137">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD67236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C50A2.3a"/>
        </source>
    </evidence>
    <sequence length="186" mass="20327" checksum="53AC74D89AE97CD9" modified="1998-06-01" version="1">MDSLIVPTTPETHFFRSGNATTEIWEVILVASCPIIFIVFLCLCVVCLVVRSYERPVLPSVQALRASASSSSQIASILRQLPPPPKYDIAVTSVDAPPPFYSDIGKEIAPGFRTTPSGARPMSMNRQFQNQHHLSTPTVQPLNIQYLYPPRYEATLPSSECKQAPRVEHVVVEIGGDATTNSTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>O44161</accession>
    <name>O44161_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">zhit-1</name>
        <name evidence="7" type="ORF">CD4.7</name>
        <name evidence="5" type="ORF">CELE_CD4.7</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD65122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T32530">
        <property type="entry name" value="T32530"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_504477.2">
        <property type="nucleotide sequence ID" value="NM_072076.8"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O44161"/>
    <dbReference type="SMR" id="O44161"/>
    <dbReference type="GeneID" id="183878"/>
    <dbReference type="UCSC" id="CD4.7b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016992"/>
    <dbReference type="CTD" id="183878"/>
    <dbReference type="WormBase" id="CD4.7a">
        <property type="protein sequence ID" value="CE35262"/>
        <property type="gene ID" value="WBGene00016992"/>
        <property type="gene designation" value="zhit-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2099063_0_0_1"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016992">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O44161">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD65122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="CD4.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="O44161"/>
        </source>
    </evidence>
    <sequence length="116" mass="13035" checksum="147DFF7B380EB14D" modified="2003-10-01" version="2">MIGGPSAKKAKKVKEDKSGIVHGEKARRRKLARPEFNKQRFKKSFNAHVIEQSKAILDSAEPDYRRVNAYQLSSAPPSEKPARKFCAVCGIISKYCCTRCGANFFQILLTSMSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2025-10-08" version="186" xmlns="https://uniprot.org/uniprot">
    <accession>O44164</accession>
    <name>O44164_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Potassium voltage-gated channel protein eag</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">egl-2</name>
        <name evidence="20" type="ORF">CELE_F16B3.1</name>
        <name evidence="22" type="ORF">F16B3.1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <property type="gene designation" value="egl-2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
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            <end position="484"/>
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        <location>
            <begin position="93"/>
            <end position="145"/>
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        <location>
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            <end position="668"/>
        </location>
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        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="892"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50113"/>
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        <source>
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    <sequence length="956" mass="108091" checksum="E998B7F2128054A8" modified="2001-10-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>O45488</accession>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
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        <property type="gene ID" value="WBGene00009535"/>
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            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF14534"/>
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            <dbReference type="EMBL" id="CAB05188.1"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="F38C2.1a"/>
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    <sequence length="109" mass="11977" checksum="109CB4C32901AA18" modified="1998-06-01" version="1">MASYTSEQAEALLKLQFDKYAKFIDDEVWAEVEGYYHPSGVLVHKGKEAVYGNKDKSTYIAKFAEGTGKSVGTTTNAKYEGSGDYLIITADFSSETEKAGTVKGRFVQI</sequence>
</entry>
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    <accession>O45526-2</accession>
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        <recommendedName>
            <fullName evidence="1">Isoform b of Zinc finger protein lsy-27</fullName>
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        <name evidence="3" type="primary">lsy-27</name>
        <name evidence="3" type="ORF">F47H4.1</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Genetics" volume="188" first="753" last="759">
            <title>A left/right asymmetric neuronal differentiation program is controlled by the Caenorhabditis elegans lsy-27 zinc-finger transcription factor.</title>
            <authorList>
                <person name="Zhang F."/>
                <person name="O'Meara M.M."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="21555395"/>
            <dbReference type="DOI" id="10.1534/genetics.111.129064"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF SER-148</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O45526-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_061399"/>
        </isoform>
        <isoform>
            <id>O45526-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001256740.1">
        <property type="nucleotide sequence ID" value="NM_001269811.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F47H4.1b">
        <property type="protein sequence ID" value="CE47185"/>
        <property type="gene ID" value="WBGene00009834"/>
        <property type="gene designation" value="lsy-27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F47H4.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F47H4.1b"/>
        </source>
    </evidence>
    <sequence length="204" mass="22497" checksum="F24544203EC32556" modified="1998-06-01" version="1">MHSNEHTCMMCERALNQKETIREHMRNEHNLAQVFTCGCCNWTFASKRQLTEHTKCIQGTGAPGDTIPIAKSINAPGSLIQSTIQGTPPVVKTGRKRPMGGSLSPSSSVSTSISSRDASGSPPPTEEEAERKVLFDNAVDTILQSKFFTYQQITEVDTWVKIIESANTLADTLQRIKKSQKVKAEGPAVESKMIPEKHVKQEIE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-12-01" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>P28192-2</accession>
    <name>PTP4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Tyrosine-protein phosphatase 4</fullName>
            <ecNumber>3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Protein-tyrosine phosphatase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ptrg-1</name>
        <name evidence="1" type="synonym">ptp-4</name>
        <name evidence="1" type="ORF">K04D7.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="Immunogenetics" volume="33" first="33" last="41">
            <title>Protein tyrosine phosphatase domains from the protochordate Styela plicata.</title>
            <authorList>
                <person name="Matthews R.J."/>
                <person name="Flores E."/>
                <person name="Thomas M.L."/>
            </authorList>
            <dbReference type="PubMed" id="1704870"/>
            <dbReference type="DOI" id="10.1007/BF00211693"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 735-842</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P28192-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_047522"/>
        </isoform>
        <isoform>
            <id>P28192-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48"/>
    <dbReference type="RefSeq" id="NP_001255471.1">
        <property type="nucleotide sequence ID" value="NM_001268542.3"/>
    </dbReference>
    <dbReference type="WormBase" id="K04D7.4b">
        <property type="protein sequence ID" value="CE44709"/>
        <property type="gene ID" value="WBGene00010558"/>
        <property type="gene designation" value="ptrg-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="K04D7.4a"/>
        </source>
    </evidence>
    <sequence length="1113" mass="126030" checksum="9D42E1BD625A272E" modified="2007-07-10" version="3" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>P34600-2</accession>
    <name>YO61_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of WW domain-containing protein ZK1098.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prp-40</name>
        <name type="ORF">ZK1098.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Dev. Biol." volume="338" first="237" last="250">
            <title>UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration.</title>
            <authorList>
                <person name="Fridolfsson H.N."/>
                <person name="Ly N."/>
                <person name="Meyerzon M."/>
                <person name="Starr D.A."/>
            </authorList>
            <dbReference type="PubMed" id="20005871"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2009.12.004"/>
        </citation>
        <scope>INTERACTION WITH UNC-83</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34600-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34600-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_043943"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255006.1">
        <property type="nucleotide sequence ID" value="NM_001268077.3"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK1098.1b">
        <property type="protein sequence ID" value="CE46142"/>
        <property type="gene ID" value="WBGene00014218"/>
        <property type="gene designation" value="prp-40"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="ZK1098.1a"/>
        </source>
    </evidence>
    <sequence length="413" mass="49430" checksum="4377EAC3A5AFE83D" modified="1996-02-01" version="2">MKESLKYQKASDIFSKEPLWIAVNDEDRKEIFRDCIDFVARRDKEKKEEDRKRDIAAFSHVLQSMEQITYKTTWAQAQRILYENPQFAERKDLHFMDKEDALTVFEDHIKQAEKEHDEEKEQEEKRLRRQQRKVREEYRLLLESLHKRGELTSMSLWTSLFPIISTDTRFELMLFQPGSSPLDLFKFFVEDLKEQYTEDRRLIKEILTEKGCQVIATTEYREFSDWVVSHEKGGKVDHGNMKLCYNSLIEKAESKAKDEEKESLRRKRRLESEFRNLLKEHNVDKDSEWTVIKPKIEKDKAYLAMENDDERETAFNHYKNGTSGTTAGSEILEKKKKKKDKKKKNKRSDNNSESEGEIREKEKKKKKKHSKEDRMDDEERGKKSKKSRKRSPSRSESPRHSSEKRKRRESEAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2026-01-28" version="172" xmlns="https://uniprot.org/uniprot">
    <accession>P48180-2</accession>
    <name>ACH1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Acetylcholine receptor subunit alpha-type acr-16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">acr-16</name>
        <name type="synonym">Ce21</name>
        <name type="ORF">F25G6.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Mol. Biol." volume="258" first="261" last="269">
            <title>Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ballivet M."/>
                <person name="Alliod C."/>
                <person name="Bertrand S."/>
                <person name="Bertrand D."/>
            </authorList>
            <dbReference type="PubMed" id="8627624"/>
            <dbReference type="DOI" id="10.1006/jmbi.1996.0248"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2004-01" db="EMBL/GenBank/DDBJ databases">
            <title>The Caenorhabditis elegans transcriptome project, a complementary view of the genome.</title>
            <authorList>
                <person name="Kohara Y."/>
                <person name="Shin-i T."/>
                <person name="Suzuki Y."/>
                <person name="Sugano S."/>
                <person name="Thierry-Mieg D."/>
                <person name="Thierry-Mieg J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="J. Biol. Chem." volume="280" first="27013" last="27021">
            <title>acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction.</title>
            <authorList>
                <person name="Touroutine D."/>
                <person name="Fox R.M."/>
                <person name="Von Stetina S.E."/>
                <person name="Burdina A."/>
                <person name="Miller D.M. III"/>
                <person name="Richmond J.E."/>
            </authorList>
            <dbReference type="PubMed" id="15917232"/>
            <dbReference type="DOI" id="10.1074/jbc.M502818200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Neuron" volume="46" first="581" last="594">
            <title>The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction.</title>
            <authorList>
                <person name="Francis M.M."/>
                <person name="Evans S.P."/>
                <person name="Jensen M."/>
                <person name="Madsen D.M."/>
                <person name="Mancuso J."/>
                <person name="Norman K.R."/>
                <person name="Maricq A.V."/>
            </authorList>
            <dbReference type="PubMed" id="15944127"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2005.04.010"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="Nat. Neurosci." volume="10" first="49" last="57">
            <title>PKC-1 regulates secretion of neuropeptides.</title>
            <authorList>
                <person name="Sieburth D."/>
                <person name="Madison J.M."/>
                <person name="Kaplan J.M."/>
            </authorList>
            <dbReference type="PubMed" id="17128266"/>
            <dbReference type="DOI" id="10.1038/nn1810"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P48180-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P48180-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_036472"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="498" mass="57254" checksum="8699EB8BBC825C44" modified="1996-02-01" version="1" precursor="true">MSVCTLLISCAILAAPTLGSLQERRLYEDLMRNYNNLERPVANHSEPVTVHLKVALQQIIDVDEKNQVVYVNAWLDYTWNDYNLVWDKAEYGNITDVRFPAGKIWKPDVLLYNSVDTNFDSTYQTNMIVYSTGLVHWVPPGIFKISCKIDIQWFPFDEQKCFFKFGSWTYDGYKLDLQPATGGFDISEYISNGEWALPLTTVERNEKFYDCCPEPYPDVHFYLHMRRRTLYYGFNLIMPCILTTLMTLLGFTLPPDAGEKITLQITVLLSICFFLSIVSEMSPPTSEAVPLLGIFFTCCMIVVTASTVFTVYVLNLHYRTPETHDMGPWTRNLLLYWIPWILRMKRPGHNLTYASLPSLFSTKPNRHSESLIRNIKDNEHSLSRANSFDADCRLNQYIMTQSVSNGLTSLGSIPSTMISSNGTTTDVSQQATLLILHRIYHELKIVTKRMIEGDKEEQACNNWKFAAMVRTYISRKIENFFIIVSTIGIFWSAPYLVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>P54137-2</accession>
    <name>NTH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Endonuclease III homolog</fullName>
            <shortName>CeNTH</shortName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
            <ecNumber evidence="1">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="1">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nth-1</name>
        <name type="ORF">R10E4.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE INITIATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Genetics" volume="174" first="57" last="65">
            <title>The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation.</title>
            <authorList>
                <person name="Denver D.R."/>
                <person name="Feinberg S."/>
                <person name="Steding C."/>
                <person name="Durbin M."/>
                <person name="Lynch M."/>
            </authorList>
            <dbReference type="PubMed" id="16783005"/>
            <dbReference type="DOI" id="10.1534/genetics.106.059840"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="DNA Repair" volume="8" first="844" last="851">
            <title>Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: essential role of N-terminal region.</title>
            <authorList>
                <person name="Morinaga H."/>
                <person name="Yonekura S."/>
                <person name="Nakamura N."/>
                <person name="Sugiyama H."/>
                <person name="Yonei S."/>
                <person name="Zhang-Akiyama Q.M."/>
            </authorList>
            <dbReference type="PubMed" id="19481506"/>
            <dbReference type="DOI" id="10.1016/j.dnarep.2009.04.020"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D)</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <event type="alternative initiation"/>
        <isoform>
            <id>P54137-1</id>
            <name>d</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P54137-4</id>
            <name>c</name>
            <sequence type="described" ref="VSP_041643"/>
        </isoform>
        <isoform>
            <id>P54137-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_041642"/>
        </isoform>
        <isoform>
            <id>P54137-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_041641"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Produced by alternative initiation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EC" id="4.2.99.18" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001254907.1">
        <property type="nucleotide sequence ID" value="NM_001267978.2"/>
    </dbReference>
    <dbReference type="WormBase" id="R10E4.5a">
        <property type="protein sequence ID" value="CE44645"/>
        <property type="gene ID" value="WBGene00011201"/>
        <property type="gene designation" value="nth-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="293" mass="32527" checksum="1FF1D1B8626B6B8E" modified="2011-07-27" version="2">MKRVVASSSVAAVATCDVEGTVVAWRRDVELIRKMRKDMIAPVDTMGCHKLADPLAAPPVHRFQVLVALMLSSQTRDEVNAAAMKRLKDHGLSIGKILEFKVPDLETILCPVGFYKRKAVYLQKTAKILKDDFSGDIPDSLDGLCALPGVGPKMANLVMQIAWGECVGIAVDTHVHRISNRLGWIKTSTPEKTQKALEILLPKSEWQPINHLLVGFGQMQCQPVRPKCGTCLCRFTCPSSTAKNVKSETEETSTSIEVKQEVEDEFEDEKPAKKIKKTRKTRTKIEVKTESET</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>P54137-3</accession>
    <name>NTH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Endonuclease III homolog</fullName>
            <shortName>CeNTH</shortName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
            <ecNumber evidence="1">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="1">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nth-1</name>
        <name type="ORF">R10E4.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE INITIATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Genetics" volume="174" first="57" last="65">
            <title>The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation.</title>
            <authorList>
                <person name="Denver D.R."/>
                <person name="Feinberg S."/>
                <person name="Steding C."/>
                <person name="Durbin M."/>
                <person name="Lynch M."/>
            </authorList>
            <dbReference type="PubMed" id="16783005"/>
            <dbReference type="DOI" id="10.1534/genetics.106.059840"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="DNA Repair" volume="8" first="844" last="851">
            <title>Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: essential role of N-terminal region.</title>
            <authorList>
                <person name="Morinaga H."/>
                <person name="Yonekura S."/>
                <person name="Nakamura N."/>
                <person name="Sugiyama H."/>
                <person name="Yonei S."/>
                <person name="Zhang-Akiyama Q.M."/>
            </authorList>
            <dbReference type="PubMed" id="19481506"/>
            <dbReference type="DOI" id="10.1016/j.dnarep.2009.04.020"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D)</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <event type="alternative initiation"/>
        <isoform>
            <id>P54137-1</id>
            <name>d</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P54137-4</id>
            <name>c</name>
            <sequence type="described" ref="VSP_041643"/>
        </isoform>
        <isoform>
            <id>P54137-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_041642"/>
        </isoform>
        <isoform>
            <id>P54137-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_041641"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Produced by alternative splicing.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EC" id="4.2.99.18" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001254908.1">
        <property type="nucleotide sequence ID" value="NM_001267979.3"/>
    </dbReference>
    <dbReference type="WormBase" id="R10E4.5b">
        <property type="protein sequence ID" value="CE44659"/>
        <property type="gene ID" value="WBGene00011201"/>
        <property type="gene designation" value="nth-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="224" mass="25017" checksum="25407C4744713639" modified="2011-07-27" version="2">MLSSQTRDEVNAAAMKRLKDHGLSIGKILEFKVPDLETILCPVGFYKRKAVYLQKTAKILKDDFSGDIPDSLDGLCALPGVGPKMANLVMQIAWGECVGIAVDTHVHRISNRLGWIKTSTPEKTQKALEILLPKSEWQPINHLLVGFGQMQCQPVRPKCGTCLCRFTCPSSTAKNVKSETEETSTSIEVKQEVEDEFEDEKPAKKIKKTRKTRTKIEVKTESET</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>P54137-4</accession>
    <name>NTH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Endonuclease III homolog</fullName>
            <shortName>CeNTH</shortName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
            <ecNumber evidence="1">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="1">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nth-1</name>
        <name type="ORF">R10E4.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE INITIATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Genetics" volume="174" first="57" last="65">
            <title>The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation.</title>
            <authorList>
                <person name="Denver D.R."/>
                <person name="Feinberg S."/>
                <person name="Steding C."/>
                <person name="Durbin M."/>
                <person name="Lynch M."/>
            </authorList>
            <dbReference type="PubMed" id="16783005"/>
            <dbReference type="DOI" id="10.1534/genetics.106.059840"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="DNA Repair" volume="8" first="844" last="851">
            <title>Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: essential role of N-terminal region.</title>
            <authorList>
                <person name="Morinaga H."/>
                <person name="Yonekura S."/>
                <person name="Nakamura N."/>
                <person name="Sugiyama H."/>
                <person name="Yonei S."/>
                <person name="Zhang-Akiyama Q.M."/>
            </authorList>
            <dbReference type="PubMed" id="19481506"/>
            <dbReference type="DOI" id="10.1016/j.dnarep.2009.04.020"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D)</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <event type="alternative initiation"/>
        <isoform>
            <id>P54137-4</id>
            <name>c</name>
            <sequence type="described" ref="VSP_041643"/>
        </isoform>
        <isoform>
            <id>P54137-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_041641"/>
        </isoform>
        <isoform>
            <id>P54137-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_041642"/>
        </isoform>
        <isoform>
            <id>P54137-1</id>
            <name>d</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Produced by alternative splicing.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EC" id="4.2.99.18" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001254909.1">
        <property type="nucleotide sequence ID" value="NM_001267980.3"/>
    </dbReference>
    <dbReference type="WormBase" id="R10E4.5c">
        <property type="protein sequence ID" value="CE44689"/>
        <property type="gene ID" value="WBGene00011201"/>
        <property type="gene designation" value="nth-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="140" mass="15858" checksum="BB4A45A3DC81D3CD" modified="2011-07-27" version="2">MANLVMQIAWGECVGIAVDTHVHRISNRLGWIKTSTPEKTQKALEILLPKSEWQPINHLLVGFGQMQCQPVRPKCGTCLCRFTCPSSTAKNVKSETEETSTSIEVKQEVEDEFEDEKPAKKIKKTRKTRTKIEVKTESET</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="154" xmlns="https://uniprot.org/uniprot">
    <accession>Q09357-2</accession>
    <name>MET16_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.346</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N(6)-adenosine-methyltransferase mett-10</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mett-10</name>
        <name evidence="4" type="ORF">ZK1128.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Genetics" volume="183" first="233" last="247">
            <title>METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dorsett M."/>
                <person name="Westlund B."/>
                <person name="Schedl T."/>
            </authorList>
            <dbReference type="PubMed" id="19596901"/>
            <dbReference type="DOI" id="10.1534/genetics.109.105270"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF 1-MET--THR-260; GLY-110; 240-PHE--ALA-392; GLY-263; 276-GLN--ARG-479 AND GLY-292</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Mol. Cell. Biol." volume="29" first="6128" last="6139">
            <title>A role for dynein in the inhibition of germ cell proliferative fate.</title>
            <authorList>
                <person name="Dorsett M."/>
                <person name="Schedl T."/>
            </authorList>
            <dbReference type="PubMed" id="19752194"/>
            <dbReference type="DOI" id="10.1128/MCB.00815-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH DLC-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF 1-MET--THR-260; GLY-110; 240-PHE--ALA-392; GLY-263; 276-GLN--ARG-479; GLY-292; 361-ALA--ALA-367; ASP-420; ASN-421; SER-423; GLN-424; TYR-426 AND PHE-427</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2021" name="Cell" volume="0" first="0" last="0">
            <title>Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing.</title>
            <authorList>
                <person name="Mendel M."/>
                <person name="Delaney K."/>
                <person name="Pandey R.R."/>
                <person name="Chen K.M."/>
                <person name="Wenda J.M."/>
                <person name="Vaagboe C.B."/>
                <person name="Steiner F.A."/>
                <person name="Homolka D."/>
                <person name="Pillai R.S."/>
            </authorList>
            <dbReference type="PubMed" id="33930289"/>
            <dbReference type="DOI" id="10.1016/j.cell.2021.03.062"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09357-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_007120"/>
        </isoform>
        <isoform>
            <id>Q09357-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.1.1.346" evidence="1"/>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="RefSeq" id="NP_871660.1">
        <property type="nucleotide sequence ID" value="NM_181931.10"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK1128.2b">
        <property type="protein sequence ID" value="CE31861"/>
        <property type="gene ID" value="WBGene00014228"/>
        <property type="gene designation" value="mett-10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="33930289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="19596901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK1128.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK1128.2b"/>
        </source>
    </evidence>
    <sequence length="464" mass="52352" checksum="7528BB54FB81B8AE" modified="2003-04-11" version="2">MSQNNEMHPRNPYRNKPPDFKALAVEYPEFRKFCQYVSNGKVTFDFKKDAAVRCLTQTLLKKDFNLDVEIPPGHLVPRVPQKLNYCLLIDDLLKANKLTKNVIGARQFNWKFIATDGDEKSVRVAHENVAKNGLSSSICVVHVNPDVKTVLMDVVNTIPDTDYAFCMCNPPFFEKGNGDDKFCEDISSSTETYSNRVASEFRTAPHSATFASSAELFVDGGEVAFVNRIIDDSVLLRDRIKIYTTMIGRKSSLKPLQNRLQRFGDDVKIMISVLNQGKTKRWMLAWTFSKSVSLTTIDRPISFQCPKPGLTRLMQEISILNGRLRQEDTLAIVAEFKCVTWTNQRARKRAKAILSESSIKKAKWNFSNVACQVAFGAGDGKDSYTDAGNFVSSESIPTNNLNAWDNASQAYFPLPNGEVPGPIIRIRIQVFSEDSYDSISFELISGSKQHLHQLVQYLKNLICR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q10120-2</accession>
    <name>LIN52_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Protein lin-52</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Abnormal cell lineage protein 52</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lin-52</name>
        <name evidence="1" type="ORF">ZK632.13</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Genetics" volume="164" first="135" last="151">
            <title>New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Thomas J.H."/>
                <person name="Ceol C.J."/>
                <person name="Schwartz H.T."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="12750327"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>INTERACTION WITH LIN-35</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Genetics" volume="171" first="1017" last="1031">
            <title>lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein.</title>
            <authorList>
                <person name="Davison E.M."/>
                <person name="Harrison M.M."/>
                <person name="Walhout A.J."/>
                <person name="Vidal M."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="16020796"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034173"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLU-36</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="16782" last="16787">
            <title>Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.</title>
            <authorList>
                <person name="Harrison M.M."/>
                <person name="Ceol C.J."/>
                <person name="Lu X."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="17075059"/>
            <dbReference type="DOI" id="10.1073/pnas.0608461103"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN THE DRM COMPLEX</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="0" last="0">
            <title>A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes.</title>
            <authorList>
                <person name="Lee J."/>
                <person name="Taylor C.A."/>
                <person name="Barnes K.M."/>
                <person name="Shen A."/>
                <person name="Stewart E.V."/>
                <person name="Chen A."/>
                <person name="Xiang Y.K."/>
                <person name="Bao Z."/>
                <person name="Shen K."/>
            </authorList>
            <dbReference type="PubMed" id="31386623"/>
            <dbReference type="DOI" id="10.7554/elife.46703"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ZTF-11</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q10120-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q10120-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_060463"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255034.1">
        <property type="nucleotide sequence ID" value="NM_001268105.3"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK632.13b">
        <property type="protein sequence ID" value="CE46358"/>
        <property type="gene ID" value="WBGene00003035"/>
        <property type="gene designation" value="lin-52"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="ZK632.13a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="ZK632.13b"/>
        </source>
    </evidence>
    <sequence length="121" mass="13486" checksum="1591F2E0AF4985F2" modified="1996-02-01" version="1">MLECTETMPEESEPVPMKCLDFEEAFQSESVSKGYESPYKNISFLKEDAVTVNTMSHCPADDIAKLIRNIQNSVYTLGIEEARQCRRGKLLNVLKPTGSASPRYLQPTPPKNVAEETTGSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q21890-2</accession>
    <name>YF64_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Uncharacterized protein R102.4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">R102.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21890-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_011905"/>
        </isoform>
        <isoform>
            <id>Q21890-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_028794"/>
        </isoform>
        <isoform>
            <id>Q21890-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_501978.3">
        <property type="nucleotide sequence ID" value="NM_069577.6"/>
    </dbReference>
    <dbReference type="WormBase" id="R102.4a">
        <property type="protein sequence ID" value="CE41252"/>
        <property type="gene ID" value="WBGene00011291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="408" mass="45163" checksum="DB6BA79562E6D512" modified="2007-10-23" version="3">MYSLLTRRVIVLGNVCIRNFSIRGAMTKVNGNSNGNGISASTDLLDTPSAYTQKSNKTHTSIDLRSDTVTVPSVEMRRAMAEAIVGDDVYGEDTTTNRLEQRCAELFGKEAGLFVTSGTMGNLLAIMAHCQRGEEIIVGRYNHIHRWEQGNYAQFAGISATTLEVKPDGTMDLNDIEQAIRVKDCHMPASKLICIENTHNYTGGKALPIEWMRSVKQLAERRDLKVHMDGARIYNAAVASNCSVSKIASFADTVQMCFSKGLGAPVGSIVVGPKDFIDRARHSRKALGGGWRQSGILAAAAHIALDHADATIRADHERAKTLARMINDATPEEFRTKVFAAEKDITNMVLVHCQNGVTVQQLTDFFQKHDILAMTFDARRIRMVLNWNVSDENLETIVEVYKKFLKQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q21890-3</accession>
    <name>YF64_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Uncharacterized protein R102.4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">R102.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21890-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q21890-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_011905"/>
        </isoform>
        <isoform>
            <id>Q21890-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_028794"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001076701.2">
        <property type="nucleotide sequence ID" value="NM_001083232.5"/>
    </dbReference>
    <dbReference type="WormBase" id="R102.4c">
        <property type="protein sequence ID" value="CE41254"/>
        <property type="gene ID" value="WBGene00011291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="383" mass="42328" checksum="F5189ABD6B998624" modified="2007-10-23" version="3">MTKVNGNSNGNGISASTDLLDTPSAYTQKSNKTHTSIDLRSDTVTVPSVEMRRAMAEAIVGDDVYGEDTTTNRLEQRCAELFGKEAGLFVTSGTMGNLLAIMAHCQRGEEIIVGRYNHIHRWEQGNYAQFAGISATTLEVKPDGTMDLNDIEQAIRVKDCHMPASKLICIENTHNYTGGKALPIEWMRSVKQLAERRDLKVHMDGARIYNAAVASNCSVSKIASFADTVQMCFSKGLGAPVGSIVVGPKDFIDRARHSRKALGGGWRQSGILAAAAHIALDHADATIRADHERAKTLARMINDATPEEFRTKVFAAEKDITNMVLVHCQNGVTVQQLTDFFQKHDILAMTFDARRIRMVLNWNVSDENLETIVEVYKKFLKQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-12-20" modified="2026-01-28" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>Q23272-2</accession>
    <name>ATFS1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Stress activated transcription factor atfs-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atfs-1</name>
        <name evidence="4" type="ORF">ZC376.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2012" name="Science" volume="337" first="587" last="590">
            <title>Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.</title>
            <authorList>
                <person name="Nargund A.M."/>
                <person name="Pellegrino M.W."/>
                <person name="Fiorese C.J."/>
                <person name="Baker B.M."/>
                <person name="Haynes C.M."/>
            </authorList>
            <dbReference type="PubMed" id="22700657"/>
            <dbReference type="DOI" id="10.1126/science.1223560"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>NUCLEAR LOCALIZATION SIGNAL</scope>
        <scope>MUTAGENESIS OF 436-ARG--LYS-441</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2014" name="Nature" volume="516" first="414" last="417">
            <title>Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection.</title>
            <authorList>
                <person name="Pellegrino M.W."/>
                <person name="Nargund A.M."/>
                <person name="Kirienko N.V."/>
                <person name="Gillis R."/>
                <person name="Fiorese C.J."/>
                <person name="Haynes C.M."/>
            </authorList>
            <dbReference type="PubMed" id="25274306"/>
            <dbReference type="DOI" id="10.1038/nature13818"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>NUCLEAR LOCALIZATION SIGNAL</scope>
        <scope>MUTAGENESIS OF 436-ARG--LYS-441</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2015" name="Mol. Cell" volume="58" first="123" last="133">
            <title>Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).</title>
            <authorList>
                <person name="Nargund A.M."/>
                <person name="Fiorese C.J."/>
                <person name="Pellegrino M.W."/>
                <person name="Deng P."/>
                <person name="Haynes C.M."/>
            </authorList>
            <dbReference type="PubMed" id="25773600"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2015.02.008"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION (ISOFORM B)</scope>
        <scope>NUCLEAR LOCALIZATION SIGNAL</scope>
        <scope>MUTAGENESIS OF ARG-4 AND 436-ARG--LYS-441</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2016" name="Nature" volume="533" first="416" last="419">
            <title>Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response.</title>
            <authorList>
                <person name="Lin Y.F."/>
                <person name="Schulz A.M."/>
                <person name="Pellegrino M.W."/>
                <person name="Lu Y."/>
                <person name="Shaham S."/>
                <person name="Haynes C.M."/>
            </authorList>
            <dbReference type="PubMed" id="27135930"/>
            <dbReference type="DOI" id="10.1038/nature17989"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-4</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2016" name="PLoS ONE" volume="11" first="E0159989" last="E0159989">
            <title>The mitochondrial unfolded protein response protects against anoxia in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Pena S."/>
                <person name="Sherman T."/>
                <person name="Brookes P.S."/>
                <person name="Nehrke K."/>
            </authorList>
            <dbReference type="PubMed" id="27459203"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0159989"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-6</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="0" last="0">
            <title>SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.</title>
            <authorList>
                <person name="Gao K."/>
                <person name="Li Y."/>
                <person name="Hu S."/>
                <person name="Liu Y."/>
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            <dbReference type="DOI" id="10.7554/elife.41792"/>
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        <scope>SUBCELLULAR LOCATION</scope>
        <scope>SUMOYLATION AT 342</scope>
        <scope>MUTAGENESIS OF LYS-342</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>A feedback loop governs the relationship between lipid metabolism and longevity.</title>
            <authorList>
                <person name="Littlejohn N.K."/>
                <person name="Seban N."/>
                <person name="Liu C.C."/>
                <person name="Srinivasan S."/>
            </authorList>
            <dbReference type="PubMed" id="33078707"/>
            <dbReference type="DOI" id="10.7554/elife.58815"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    </evidence>
    <evidence type="ECO:0000312" key="7">
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
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    <reference evidence="1" key="2">
        <citation type="journal article" date="2012" name="Science" volume="337" first="587" last="590">
            <title>Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.</title>
            <authorList>
                <person name="Nargund A.M."/>
                <person name="Pellegrino M.W."/>
                <person name="Fiorese C.J."/>
                <person name="Baker B.M."/>
                <person name="Haynes C.M."/>
            </authorList>
            <dbReference type="PubMed" id="22700657"/>
            <dbReference type="DOI" id="10.1126/science.1223560"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>NUCLEAR LOCALIZATION SIGNAL</scope>
        <scope>MUTAGENESIS OF 436-ARG--LYS-441</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2014" name="Nature" volume="516" first="414" last="417">
            <title>Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection.</title>
            <authorList>
                <person name="Pellegrino M.W."/>
                <person name="Nargund A.M."/>
                <person name="Kirienko N.V."/>
                <person name="Gillis R."/>
                <person name="Fiorese C.J."/>
                <person name="Haynes C.M."/>
            </authorList>
            <dbReference type="PubMed" id="25274306"/>
            <dbReference type="DOI" id="10.1038/nature13818"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>NUCLEAR LOCALIZATION SIGNAL</scope>
        <scope>MUTAGENESIS OF 436-ARG--LYS-441</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2015" name="Mol. Cell" volume="58" first="123" last="133">
            <title>Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).</title>
            <authorList>
                <person name="Nargund A.M."/>
                <person name="Fiorese C.J."/>
                <person name="Pellegrino M.W."/>
                <person name="Deng P."/>
                <person name="Haynes C.M."/>
            </authorList>
            <dbReference type="PubMed" id="25773600"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2015.02.008"/>
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        <scope>FUNCTION</scope>
        <scope>INDUCTION (ISOFORM B)</scope>
        <scope>NUCLEAR LOCALIZATION SIGNAL</scope>
        <scope>MUTAGENESIS OF ARG-4 AND 436-ARG--LYS-441</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2016" name="Nature" volume="533" first="416" last="419">
            <title>Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response.</title>
            <authorList>
                <person name="Lin Y.F."/>
                <person name="Schulz A.M."/>
                <person name="Pellegrino M.W."/>
                <person name="Lu Y."/>
                <person name="Shaham S."/>
                <person name="Haynes C.M."/>
            </authorList>
            <dbReference type="PubMed" id="27135930"/>
            <dbReference type="DOI" id="10.1038/nature17989"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-4</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2016" name="PLoS ONE" volume="11" first="E0159989" last="E0159989">
            <title>The mitochondrial unfolded protein response protects against anoxia in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Pena S."/>
                <person name="Sherman T."/>
                <person name="Brookes P.S."/>
                <person name="Nehrke K."/>
            </authorList>
            <dbReference type="PubMed" id="27459203"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0159989"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-6</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="0" last="0">
            <title>SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.</title>
            <authorList>
                <person name="Gao K."/>
                <person name="Li Y."/>
                <person name="Hu S."/>
                <person name="Liu Y."/>
            </authorList>
            <dbReference type="PubMed" id="30642431"/>
            <dbReference type="DOI" id="10.7554/elife.41792"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>SUMOYLATION AT 342</scope>
        <scope>MUTAGENESIS OF LYS-342</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>A feedback loop governs the relationship between lipid metabolism and longevity.</title>
            <authorList>
                <person name="Littlejohn N.K."/>
                <person name="Seban N."/>
                <person name="Liu C.C."/>
                <person name="Srinivasan S."/>
            </authorList>
            <dbReference type="PubMed" id="33078707"/>
            <dbReference type="DOI" id="10.7554/elife.58815"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q23272-2</id>
            <name evidence="4">b</name>
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        <isoform>
            <id>Q23272-1</id>
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            <id>Q23272-4</id>
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        <isoform>
            <id>Q23272-3</id>
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            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="ZC376.7a"/>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000312" key="6">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2012" name="Science" volume="337" first="587" last="590">
            <title>Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.</title>
            <authorList>
                <person name="Nargund A.M."/>
                <person name="Pellegrino M.W."/>
                <person name="Fiorese C.J."/>
                <person name="Baker B.M."/>
                <person name="Haynes C.M."/>
            </authorList>
            <dbReference type="PubMed" id="22700657"/>
            <dbReference type="DOI" id="10.1126/science.1223560"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>NUCLEAR LOCALIZATION SIGNAL</scope>
        <scope>MUTAGENESIS OF 436-ARG--LYS-441</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2014" name="Nature" volume="516" first="414" last="417">
            <title>Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection.</title>
            <authorList>
                <person name="Pellegrino M.W."/>
                <person name="Nargund A.M."/>
                <person name="Kirienko N.V."/>
                <person name="Gillis R."/>
                <person name="Fiorese C.J."/>
                <person name="Haynes C.M."/>
            </authorList>
            <dbReference type="PubMed" id="25274306"/>
            <dbReference type="DOI" id="10.1038/nature13818"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>NUCLEAR LOCALIZATION SIGNAL</scope>
        <scope>MUTAGENESIS OF 436-ARG--LYS-441</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2015" name="Mol. Cell" volume="58" first="123" last="133">
            <title>Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).</title>
            <authorList>
                <person name="Nargund A.M."/>
                <person name="Fiorese C.J."/>
                <person name="Pellegrino M.W."/>
                <person name="Deng P."/>
                <person name="Haynes C.M."/>
            </authorList>
            <dbReference type="PubMed" id="25773600"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2015.02.008"/>
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        <scope>FUNCTION</scope>
        <scope>INDUCTION (ISOFORM B)</scope>
        <scope>NUCLEAR LOCALIZATION SIGNAL</scope>
        <scope>MUTAGENESIS OF ARG-4 AND 436-ARG--LYS-441</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2016" name="Nature" volume="533" first="416" last="419">
            <title>Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response.</title>
            <authorList>
                <person name="Lin Y.F."/>
                <person name="Schulz A.M."/>
                <person name="Pellegrino M.W."/>
                <person name="Lu Y."/>
                <person name="Shaham S."/>
                <person name="Haynes C.M."/>
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            <dbReference type="PubMed" id="27135930"/>
            <dbReference type="DOI" id="10.1038/nature17989"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-4</scope>
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    <reference evidence="1" key="6">
        <citation type="journal article" date="2016" name="PLoS ONE" volume="11" first="E0159989" last="E0159989">
            <title>The mitochondrial unfolded protein response protects against anoxia in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Pena S."/>
                <person name="Sherman T."/>
                <person name="Brookes P.S."/>
                <person name="Nehrke K."/>
            </authorList>
            <dbReference type="PubMed" id="27459203"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0159989"/>
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        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-6</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="0" last="0">
            <title>SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.</title>
            <authorList>
                <person name="Gao K."/>
                <person name="Li Y."/>
                <person name="Hu S."/>
                <person name="Liu Y."/>
            </authorList>
            <dbReference type="PubMed" id="30642431"/>
            <dbReference type="DOI" id="10.7554/elife.41792"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>SUMOYLATION AT 342</scope>
        <scope>MUTAGENESIS OF LYS-342</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>A feedback loop governs the relationship between lipid metabolism and longevity.</title>
            <authorList>
                <person name="Littlejohn N.K."/>
                <person name="Seban N."/>
                <person name="Liu C.C."/>
                <person name="Srinivasan S."/>
            </authorList>
            <dbReference type="PubMed" id="33078707"/>
            <dbReference type="DOI" id="10.7554/elife.58815"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZC376.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZC376.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZC376.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZC376.7d"/>
        </source>
    </evidence>
    <sequence length="281" mass="32849" checksum="664AF8DB334389B5" modified="1996-11-01" version="1" precursor="true">MPPQDRKLSKFEMDIEQESKAVDWEAWNHYLESDDDVFKRPEAFFKEEPMIMTSSDSLMTSSTSSPDSGISLYDPMIPPPSSHFPSFNLSSSSSASNLLRLSTPSAPMQQEHRAPVRMHHDVDLFSSGPLLCVPKQEDVFDDFIQQRDDDDEDYIPASEARRTSSRLNRKSATPTYLRRRDSERSWTPASDDYFPEEHQKFKKRGVVLKPSVDEETDRRRMLNRIAAVRYREKKRAEKKGRKMEFQEVADRNRILLQKERQLKREINSMKKELRKMGAIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-12-07" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5W612</accession>
    <name>Q5W612_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CELE_K07H8.2</name>
        <name evidence="11 13" type="ORF">K07H8.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD70601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5W612"/>
    <dbReference type="UCSC" id="K07H8.2b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019504"/>
    <dbReference type="WormBase" id="K07H8.2c">
        <property type="protein sequence ID" value="CE37721"/>
        <property type="gene ID" value="WBGene00019504"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018207_3_0_1"/>
    <dbReference type="OrthoDB" id="5791097at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019504">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q5W612">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000006">
        <property type="entry name" value="Protein CBG01586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="53"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="266"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD70601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="K07H8.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q5W612"/>
        </source>
    </evidence>
    <sequence length="429" mass="46559" checksum="9384ED5351AD2E42" modified="2004-12-07" version="1">MSVIPAESSYVLFFQVLFPFAVAGLGMVFAGLVLSIVVTWPLFEEIPEILILVPALLGLKGNLEMTLASRLSTLANLGHMDSSKQRKDVVIANLALVQVQATVVAFLASAFAAALAFIPSGDFDWAHGALMCASSLATACSASLVLSLLMVVVIVTSRKYNINPDNVATPIAASLGDLTTLTVLAFFGSVFLKAHNTESWLNVIVIVLFLLLLPFWIKIANENEGTQETLYNGWTPVIMSMLISSAGGFILETAVRRYHSLSTYGPVLNGVGGNLAAVQASRLSTYFHKAGTVGVLPNEWTVSRFTSVQRAFFSKEWDSRSARVLLLLVVPGHICFNFLIQLFTLTSKNNVTPHGPLFTSLYMIAAIIQVVILLFVCQLLVALLWKWKIDPDNSVIPYLTALGDLLGTGLLFIVFLTTDHFDPKELTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-12-07" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5W613</accession>
    <name>Q5W613_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">npr-37</name>
        <name evidence="2" type="ORF">CELE_M04G7.3</name>
        <name evidence="4" type="ORF">M04G7.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD73115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380027.1">
        <property type="nucleotide sequence ID" value="NM_001392246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5W613"/>
    <dbReference type="SMR" id="Q5W613"/>
    <dbReference type="GeneID" id="176876"/>
    <dbReference type="UCSC" id="M04G7.3b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019774"/>
    <dbReference type="CTD" id="176876"/>
    <dbReference type="WormBase" id="M04G7.3b">
        <property type="protein sequence ID" value="CE17192"/>
        <property type="gene ID" value="WBGene00019774"/>
        <property type="gene designation" value="npr-37"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049953_0_0_1"/>
    <dbReference type="OrthoDB" id="5780272at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019774">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q5W613">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF5">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD73115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="M04G7.3b"/>
        </source>
    </evidence>
    <sequence length="437" mass="49583" checksum="246A74136AB0C41C" modified="2004-12-07" version="1">METDYEGGMPNCSYRYPFPPEEDTISAYALLIDGPCTCVAALLSMIGARYAIKFLCRAGLNKELTAALFALCAIDSLLLLTVFLFYGIEAMSLLFFRTNIMYDKQDFTYNLHGIASSLTTASTALVIYITFLRFMVVVQPMRFATSMNSNHRRTGSKAVRKGSAQLEDSVTNNTIFSRGTFNSSSIKRHYNIRELIRPFYIPFLLILISFSVNIPIFFEFTTTKCFNVEHNVEATNPEPTVFRSSFAKYKAVLMTLTQTIGPVSIILVLSIFTEYKVHVSLKARRKLFESQQRSRSVVLSEELKETVSRTVAVFIAVKFLIFRTMPIFFDVYENLYGIDEWGTVMSIMVRVSDFGIVLNTATNSLAYFGKKRWIEKRLRLRLMKKEEKRNAKATLTVQGSSLNSSMKKSLPPKIGLPHPLSAEKTPLNSKNIYPEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q7K6X2</accession>
    <name>Q7K6X2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">INSulin related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">ins-36</name>
        <name evidence="1" type="ORF">CELE_Y53H1A.4</name>
        <name evidence="3" type="ORF">Y53H1A.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAE46684.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001364638.1">
        <property type="nucleotide sequence ID" value="NM_001377635.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7K6X2"/>
    <dbReference type="STRING" id="6239.Y53H1A.4a.1"/>
    <dbReference type="PaxDb" id="6239-Y53H1A.4a"/>
    <dbReference type="GeneID" id="3565585"/>
    <dbReference type="UCSC" id="Y53H1A.4">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00002119"/>
    <dbReference type="CTD" id="3565585"/>
    <dbReference type="WormBase" id="Y53H1A.4a">
        <property type="protein sequence ID" value="CE54008"/>
        <property type="gene ID" value="WBGene00002119"/>
        <property type="gene designation" value="ins-36"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2485356_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002119">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7K6X2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAE46684.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y53H1A.4a"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q7K783</accession>
    <name>Q7K783_CAEEL</name>
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        <submittedName>
            <fullName evidence="6">SEC7 domain-containing protein</fullName>
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        <name evidence="6 8" type="primary">agef-1</name>
        <name evidence="6" type="ORF">CELE_Y6B3A.1</name>
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    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="Q7K783"/>
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    <dbReference type="CTD" id="173231"/>
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        <property type="gene ID" value="WBGene00012386"/>
        <property type="gene designation" value="agef-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494525_0_0_1"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
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        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7K783">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF16213">
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    </dbReference>
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        <location>
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            <end position="428"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE54929.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="Y6B3A.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q7K783"/>
        </source>
    </evidence>
    <sequence length="551" mass="61344" checksum="08C17913C3A9BA4A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
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    <name>Q7Z2B3_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">Mediator complex subunit 8</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">CELE_Y55D5A.1</name>
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    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z2B3"/>
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    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021915"/>
    <dbReference type="WormBase" id="Y55D5A.1b">
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        <property type="gene ID" value="WBGene00021915"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012767_0_0_1"/>
    <dbReference type="OrthoDB" id="5820839at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021915">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z2B3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD72197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y55D5A.1b"/>
        </source>
    </evidence>
    <sequence length="162" mass="18163" checksum="224E152A435D369C" modified="2003-10-01" version="1">MMAALNEQVQQGLELFRPPTCPTAELLRSTAEKLEEIGESSLSDKLNNNPDTLQNATWQTMNTVLRVFSLTDRQVMGYLRHLKSQTPSAMPIFPRHLDTCNTYIALGDHGAYFFGQDFVCRAPMPNGTQQRRNVVDQPANAETGSDVFWYEASDTDDESATD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-19" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MLZ5-10</accession>
    <name>GAP2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform j of Ras GTPase-activating protein gap-2</fullName>
            <shortName>GTPase-activating protein 2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gap-2</name>
        <name type="ORF">ZK899.8</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Genes Cells" volume="3" first="189" last="202">
            <title>Characterization of the C. elegans gap-2 gene encoding a novel Ras-GTPase activating protein and its possible role in larval development.</title>
            <authorList>
                <person name="Hayashizaki S."/>
                <person name="Iino Y."/>
                <person name="Yamamoto M."/>
            </authorList>
            <dbReference type="PubMed" id="9619631"/>
            <dbReference type="DOI" id="10.1046/j.1365-2443.1998.00179.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D)</scope>
        <scope>PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; E; F AND G)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q8MLZ5-6</id>
            <name evidence="7">f</name>
            <name evidence="1">GAP-2-7</name>
            <sequence type="described" ref="VSP_007795 VSP_007796"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-11</id>
            <name evidence="10">k</name>
            <sequence type="described" ref="VSP_058286"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-3</id>
            <name evidence="4">c</name>
            <name evidence="1">GAP-2-3</name>
            <sequence type="described" ref="VSP_007790 VSP_007789"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-8</id>
            <name>h</name>
            <sequence type="described" ref="VSP_007789 VSP_007799 VSP_007800"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-12</id>
            <name evidence="11">l</name>
            <sequence type="described" ref="VSP_058285"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-7</id>
            <name evidence="6">g</name>
            <name evidence="1">GAP-2-9</name>
            <sequence type="described" ref="VSP_007797 VSP_007798"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-4</id>
            <name evidence="5">d</name>
            <name evidence="1">GAP-2-4</name>
            <sequence type="described" ref="VSP_007791 VSP_007792 VSP_007789"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-2</id>
            <name evidence="3">b</name>
            <name evidence="1">GAP-2-2</name>
            <sequence type="described" ref="VSP_007789 VSP_007788"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-9</id>
            <name evidence="8">i</name>
            <sequence type="described" ref="VSP_058284"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-5</id>
            <name evidence="6">e</name>
            <name evidence="1">GAP-2-5</name>
            <sequence type="described" ref="VSP_007793 VSP_007794"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-1</id>
            <name evidence="2">a</name>
            <name evidence="1">GAP-2-1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-10</id>
            <name evidence="9">j</name>
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        </isoform>
    </comment>
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        <property type="gene ID" value="WBGene00001516"/>
        <property type="gene designation" value="gap-2"/>
    </dbReference>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
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        <source>
            <dbReference type="PubMed" id="9619631"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="ZK899.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK899.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK899.8c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK899.8d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZK899.8e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="ZK899.8f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="ZK899.8i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="ZK899.8j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="ZK899.8k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="ZK899.8l"/>
        </source>
    </evidence>
    <sequence length="790" mass="88857" checksum="2B7C7B7C856BEDFF" modified="2003-07-19" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-19" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MLZ5-11</accession>
    <name>GAP2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform k of Ras GTPase-activating protein gap-2</fullName>
            <shortName>GTPase-activating protein 2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gap-2</name>
        <name type="ORF">ZK899.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Genes Cells" volume="3" first="189" last="202">
            <title>Characterization of the C. elegans gap-2 gene encoding a novel Ras-GTPase activating protein and its possible role in larval development.</title>
            <authorList>
                <person name="Hayashizaki S."/>
                <person name="Iino Y."/>
                <person name="Yamamoto M."/>
            </authorList>
            <dbReference type="PubMed" id="9619631"/>
            <dbReference type="DOI" id="10.1046/j.1365-2443.1998.00179.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D)</scope>
        <scope>PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; E; F AND G)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q8MLZ5-11</id>
            <name evidence="10">k</name>
            <sequence type="described" ref="VSP_058286"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-5</id>
            <name evidence="6">e</name>
            <name evidence="1">GAP-2-5</name>
            <sequence type="described" ref="VSP_007793 VSP_007794"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-1</id>
            <name evidence="2">a</name>
            <name evidence="1">GAP-2-1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-8</id>
            <name>h</name>
            <sequence type="described" ref="VSP_007789 VSP_007799 VSP_007800"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-2</id>
            <name evidence="3">b</name>
            <name evidence="1">GAP-2-2</name>
            <sequence type="described" ref="VSP_007789 VSP_007788"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-3</id>
            <name evidence="4">c</name>
            <name evidence="1">GAP-2-3</name>
            <sequence type="described" ref="VSP_007789 VSP_007790"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-6</id>
            <name evidence="7">f</name>
            <name evidence="1">GAP-2-7</name>
            <sequence type="described" ref="VSP_007796 VSP_007795"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-10</id>
            <name evidence="9">j</name>
            <sequence type="described" ref="VSP_058283"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-12</id>
            <name evidence="11">l</name>
            <sequence type="described" ref="VSP_058285"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-7</id>
            <name evidence="6">g</name>
            <name evidence="1">GAP-2-9</name>
            <sequence type="described" ref="VSP_007797 VSP_007798"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-9</id>
            <name evidence="8">i</name>
            <sequence type="described" ref="VSP_058284"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-4</id>
            <name evidence="5">d</name>
            <name evidence="1">GAP-2-4</name>
            <sequence type="described" ref="VSP_007792 VSP_007791 VSP_007789"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001294845.1">
        <property type="nucleotide sequence ID" value="NM_001307916.4"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK899.8k">
        <property type="protein sequence ID" value="CE48260"/>
        <property type="gene ID" value="WBGene00001516"/>
        <property type="gene designation" value="gap-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="9619631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="ZK899.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK899.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK899.8c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK899.8d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZK899.8e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="ZK899.8f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="ZK899.8i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="ZK899.8j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="ZK899.8k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="ZK899.8l"/>
        </source>
    </evidence>
    <sequence length="1205" mass="135988" checksum="E11AA30F518837B5" modified="2003-07-19" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-19" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MLZ5-12</accession>
    <name>GAP2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform l of Ras GTPase-activating protein gap-2</fullName>
            <shortName>GTPase-activating protein 2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gap-2</name>
        <name type="ORF">ZK899.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Genes Cells" volume="3" first="189" last="202">
            <title>Characterization of the C. elegans gap-2 gene encoding a novel Ras-GTPase activating protein and its possible role in larval development.</title>
            <authorList>
                <person name="Hayashizaki S."/>
                <person name="Iino Y."/>
                <person name="Yamamoto M."/>
            </authorList>
            <dbReference type="PubMed" id="9619631"/>
            <dbReference type="DOI" id="10.1046/j.1365-2443.1998.00179.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D)</scope>
        <scope>PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; E; F AND G)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q8MLZ5-9</id>
            <name evidence="8">i</name>
            <sequence type="described" ref="VSP_058284"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-10</id>
            <name evidence="9">j</name>
            <sequence type="described" ref="VSP_058283"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-11</id>
            <name evidence="10">k</name>
            <sequence type="described" ref="VSP_058286"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-6</id>
            <name evidence="7">f</name>
            <name evidence="1">GAP-2-7</name>
            <sequence type="described" ref="VSP_007796 VSP_007795"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-4</id>
            <name evidence="5">d</name>
            <name evidence="1">GAP-2-4</name>
            <sequence type="described" ref="VSP_007791 VSP_007789 VSP_007792"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-1</id>
            <name evidence="2">a</name>
            <name evidence="1">GAP-2-1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-7</id>
            <name evidence="6">g</name>
            <name evidence="1">GAP-2-9</name>
            <sequence type="described" ref="VSP_007798 VSP_007797"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-3</id>
            <name evidence="4">c</name>
            <name evidence="1">GAP-2-3</name>
            <sequence type="described" ref="VSP_007789 VSP_007790"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-8</id>
            <name>h</name>
            <sequence type="described" ref="VSP_007789 VSP_007799 VSP_007800"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-2</id>
            <name evidence="3">b</name>
            <name evidence="1">GAP-2-2</name>
            <sequence type="described" ref="VSP_007788 VSP_007789"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-5</id>
            <name evidence="6">e</name>
            <name evidence="1">GAP-2-5</name>
            <sequence type="described" ref="VSP_007793 VSP_007794"/>
        </isoform>
        <isoform>
            <id>Q8MLZ5-12</id>
            <name evidence="11">l</name>
            <sequence type="described" ref="VSP_058285"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001294843.1">
        <property type="nucleotide sequence ID" value="NM_001307914.4"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK899.8l">
        <property type="protein sequence ID" value="CE48295"/>
        <property type="gene ID" value="WBGene00001516"/>
        <property type="gene designation" value="gap-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="9619631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="ZK899.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK899.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK899.8c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK899.8d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZK899.8e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="ZK899.8f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="ZK899.8i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="ZK899.8j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="ZK899.8k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="ZK899.8l"/>
        </source>
    </evidence>
    <sequence length="948" mass="107058" checksum="0E3862DF2932E6A2" modified="2003-07-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1997-02-01" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q93620</accession>
    <name>Q93620_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F27D4.6</name>
        <name evidence="2 4" type="ORF">F27D4.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB01971.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21455">
        <property type="entry name" value="T21455"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q93620"/>
    <dbReference type="IntAct" id="Q93620">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="UCSC" id="F27D4.6a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009190"/>
    <dbReference type="WormBase" id="F27D4.6a">
        <property type="protein sequence ID" value="CE32394"/>
        <property type="gene ID" value="WBGene00009190"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5858508at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009190">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q93620">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36936:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36936">
        <property type="entry name" value="PROTEIN CBG25168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB01971.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F27D4.6a"/>
        </source>
    </evidence>
    <sequence length="1008" mass="116089" checksum="0D54F2752D512D05" modified="2003-03-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1997-02-01" modified="2025-10-08" version="166" xmlns="https://uniprot.org/uniprot">
    <accession>Q93622</accession>
    <name>Q93622_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1</fullName>
            <ecNumber evidence="11">3.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CELE_F28C6.8</name>
        <name evidence="20 22" type="ORF">F28C6.8</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:75163"/>
            <dbReference type="ChEBI" id="CHEBI:78907"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42584"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82605"/>
            <dbReference type="ChEBI" id="CHEBI:82606"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65221"/>
            <dbReference type="ChEBI" id="CHEBI:78911"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:42309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:33751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="3.1.3.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78930"/>
            <dbReference type="ChEBI" id="CHEBI:78931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42321"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.27" evidence="11"/>
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        <property type="protein sequence ID" value="CAA92677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T21489"/>
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        <property type="nucleotide sequence ID" value="NM_001267233.1"/>
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        <property type="organism name" value="c. elegans"/>
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        <property type="protein sequence ID" value="CE09746"/>
        <property type="gene ID" value="WBGene00009207"/>
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        <property type="component" value="Chromosome II"/>
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        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Tyr_Pase_AS"/>
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        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
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        <property type="entry name" value="DSPc"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
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    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="65"/>
            <end position="130"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024192"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00024224"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00050944"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00051818"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052505"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052632"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052780"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069309"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAA92677.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="F28C6.8a"/>
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    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="Q93622"/>
        </source>
    </evidence>
    <sequence length="150" mass="17170" checksum="7AD551CA14F79602" modified="1997-02-01" version="1">MPFRSMKDELIQKENVGGVVCCTEEFELKAAMNAMREVDWKNEGVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQVLLRNAHWRTVNEYRRFLDSNSSSTGSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="183" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N3Y4</accession>
    <name>Q9N3Y4_CAEEL</name>
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        <submittedName>
            <fullName evidence="8">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rabs-5</name>
        <name evidence="8" type="ORF">CELE_Y42H9AR.3</name>
        <name evidence="10" type="ORF">Y42H9AR.3</name>
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    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">Bristol N2</strain>
        </source>
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        <property type="protein sequence ID" value="CCD71168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="1"/>
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        <property type="organism name" value="c. elegans"/>
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        <property type="protein sequence ID" value="CE29111"/>
        <property type="gene ID" value="WBGene00021538"/>
        <property type="gene designation" value="rabs-5"/>
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    <dbReference type="eggNOG" id="KOG1842">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_020798_0_0_1"/>
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        <property type="component" value="Chromosome IV"/>
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    <dbReference type="Bgee" id="WBGene00021538">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N3Y4">
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        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:pinocytosis"/>
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        <property type="project" value="WormBase"/>
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        <property type="term" value="P:receptor-mediated endocytosis"/>
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        <property type="entry name" value="Rab4/Rab5_effector"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
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        <location>
            <begin position="474"/>
            <end position="489"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD71168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y42H9AR.3a"/>
        </source>
    </evidence>
    <sequence length="563" mass="63682" checksum="5864FEBD91432DD3" modified="2001-10-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N3Y7</accession>
    <name>Q9N3Y7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_Y40C5A.4</name>
        <name evidence="7 9" type="ORF">Y40C5A.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD71161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741441.1">
        <property type="nucleotide sequence ID" value="NM_171378.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N3Y7"/>
    <dbReference type="SMR" id="Q9N3Y7"/>
    <dbReference type="GeneID" id="177508"/>
    <dbReference type="UCSC" id="Y40C5A.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021497"/>
    <dbReference type="CTD" id="177508"/>
    <dbReference type="WormBase" id="Y40C5A.4a">
        <property type="protein sequence ID" value="CE24258"/>
        <property type="gene ID" value="WBGene00021497"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799915at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021497">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N3Y7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF8">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="49"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD71161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y40C5A.4a"/>
        </source>
    </evidence>
    <sequence length="407" mass="46852" checksum="EBA4D419BD7D0468" modified="2000-10-01" version="1">MDSNNISFVEEVFEDIEDECAYSPPIFLEWKMVFVGVIGLIVALISIVHNSLLFYTFSTSTVLRKRNLTYLMWISGCDVFISICYIAIMCVQVYTDYFVSFKLLVLWHDYLRTAFTVSHITLSAASFLLMAATVERYLQSTADNRTLKLFQILATHRTYVVFCCFLASLIFRGTVFFEIEVVTQPNCTGFSSMGLAVVPMFGESMDVVWRFFIRKIVTVFLPFAVLAYFNAAIVMNVRRTDRDQTVKALVLFITVGTRGEVTRLRSRLRAVTRMLVMVVTGYLLANILDIIIAFWETINIQSLQELPSLYTVLSDISSFLPIAACALRLPIYTINDRQIRVEVRRKFCYLITRCCTCCPGVLCDTHQRKKLHDNQLESERLWPKNEPTPKLEHEMTQLWTKSTERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N439</accession>
    <name>Q9N439_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anoct_dimer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y37E11AM.2</name>
        <name evidence="2 4" type="ORF">Y37E11AM.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD74035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_500404.2">
        <property type="nucleotide sequence ID" value="NM_068003.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N439"/>
    <dbReference type="PeptideAtlas" id="Q9N439"/>
    <dbReference type="GeneID" id="177134"/>
    <dbReference type="UCSC" id="Y37E11AM.2.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021366"/>
    <dbReference type="CTD" id="177134"/>
    <dbReference type="WormBase" id="Y37E11AM.2a">
        <property type="protein sequence ID" value="CE39291"/>
        <property type="gene ID" value="WBGene00021366"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1321957_0_0_1"/>
    <dbReference type="OrthoDB" id="5832955at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021366">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N439">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD74035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y37E11AM.2a"/>
        </source>
    </evidence>
    <sequence length="208" mass="24119" checksum="676C9C96137517C2" modified="2005-12-06" version="3">MDLSEREDQTSDPDEEDTECRKVSKKIASVTLESDSLPESPQTAEERTARRKKRIKRKGQQMDVDPTPKAKAESKHMDCDGFESHISSSDESYSEDNKGREADDEQSDWVGDTTPTRNPFESPFDRKVHLRKSQPNVHQTSNMQKKIEKFAREGGRGELILETRFRDRASSSLLQRYLYKYHLEVVRRHRGSIILRKKFETPSTSNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N490</accession>
    <name>Q9N490_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">ubc-15</name>
        <name evidence="2" type="ORF">CELE_Y110A2AR.2</name>
        <name evidence="4" type="ORF">Y110A2AR.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD73701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_494397.1">
        <property type="nucleotide sequence ID" value="NM_061996.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N490"/>
    <dbReference type="SMR" id="Q9N490"/>
    <dbReference type="IntAct" id="Q9N490">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="PaxDb" id="6239-Y110A2AR.2"/>
    <dbReference type="PeptideAtlas" id="Q9N490"/>
    <dbReference type="GeneID" id="173637"/>
    <dbReference type="UCSC" id="Y110A2AR.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006710"/>
    <dbReference type="CTD" id="173637"/>
    <dbReference type="WormBase" id="Y110A2AR.2a">
        <property type="protein sequence ID" value="CE26044"/>
        <property type="gene ID" value="WBGene00006710"/>
        <property type="gene designation" value="ubc-15"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1267910_0_0_1"/>
    <dbReference type="OMA" id="ICISISD"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="PhylomeDB" id="Q9N490"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006710">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N490">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000109">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD73701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y110A2AR.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N490"/>
        </source>
    </evidence>
    <sequence length="218" mass="24542" checksum="8FA69521EB1C2ECE" modified="2001-10-01" version="2">MLNLGPGVSVPAAGTASSSAVRRLQKDYAKLMQDPVDGIKALPNEDNILEWHYCLRGSPDTPFYGGYYWGKVIFKENFPWSPPAITMITPNGRFQTNTRLCLSISDYHPESWNPGWTVSAILIGLHSFMNENSPAAGSIAGTPQDQRMYAAASKEFNVKVYNWNLAGNPHCNFFLTRDEEKWFLGHGRGADKFHRPFILLCFPPVFFCFSSIFPVFSY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-01" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q9U3D4-2</accession>
    <name>SMS1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Phosphatidylcholine:ceramide cholinephosphotransferase 1</fullName>
            <shortName evidence="2">PC:ceramide cholinephosphotransferase 1</shortName>
            <ecNumber evidence="1">2.7.8.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Sphingomyelin synthase 1</fullName>
            <shortName evidence="2">CSS3alpha1</shortName>
            <shortName evidence="2">SMS-1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sms-1</name>
        <name type="ORF">H21P03.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2004" name="EMBO J." volume="23" first="33" last="44">
            <title>Identification of a family of animal sphingomyelin synthases.</title>
            <authorList>
                <person name="Huitema K."/>
                <person name="Van Den Dikkenberg J."/>
                <person name="Brouwers J.F.H.M."/>
                <person name="Holthuis J.C."/>
            </authorList>
            <dbReference type="PubMed" id="14685263"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600034"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9U3D4-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_050674"/>
        </isoform>
        <isoform>
            <id>Q9U3D4-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9U3D4-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_039807"/>
        </isoform>
        <isoform>
            <id>Q9U3D4-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_061062"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.8.27" evidence="1"/>
    <dbReference type="RefSeq" id="NP_502169.2">
        <property type="nucleotide sequence ID" value="NM_069768.6"/>
    </dbReference>
    <dbReference type="WormBase" id="H21P03.3a">
        <property type="protein sequence ID" value="CE44486"/>
        <property type="gene ID" value="WBGene00004892"/>
        <property type="gene designation" value="sms-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="14685263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="14685263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="429" mass="48400" checksum="50D2AB883B5D39AD" modified="2010-10-05" version="2">MKMSWNHQYTNYGSIADDNGDEEKAENSEGAAAEKVEKQHDDDGVVVHEETDGVASSRSSHHDKQKPGETKKSGDGKMDDDDIITTARSSSRRICGSAASSSDSETADDAPLLPDEGPSHAVRLEMPGDKPASPHDRFPKTPLKTLVAFLMLVVAAAGNTITLSWIHERYPLTPPLPDIVFELIPKIPWGLRLCENLMIGSFVSLLVLILFHRHRWIVLRRLCFIGSILYGMRCITMMVTPVPKADEDFECSPRFGENATFSLIVMRGVWSMFGLGLNLFDNQKVVLCGDYIYSGHTLVLVVSALFIGEYSPRRFYILHWLSWLVCSVGVIFLVLSHGHYTIDVILSYFACTRVFWAYHTQAAHPSIRLSVQNHQAKEFWFPLLRWFEGDIRRPVPRRFDCPISYSQVCNAFRRVRPRGRNGAARPAFE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-01" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q9U3D4-3</accession>
    <name>SMS1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Phosphatidylcholine:ceramide cholinephosphotransferase 1</fullName>
            <shortName evidence="2">PC:ceramide cholinephosphotransferase 1</shortName>
            <ecNumber evidence="1">2.7.8.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Sphingomyelin synthase 1</fullName>
            <shortName evidence="2">CSS3alpha1</shortName>
            <shortName evidence="2">SMS-1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sms-1</name>
        <name type="ORF">H21P03.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2004" name="EMBO J." volume="23" first="33" last="44">
            <title>Identification of a family of animal sphingomyelin synthases.</title>
            <authorList>
                <person name="Huitema K."/>
                <person name="Van Den Dikkenberg J."/>
                <person name="Brouwers J.F.H.M."/>
                <person name="Holthuis J.C."/>
            </authorList>
            <dbReference type="PubMed" id="14685263"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600034"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9U3D4-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_039807"/>
        </isoform>
        <isoform>
            <id>Q9U3D4-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_061062"/>
        </isoform>
        <isoform>
            <id>Q9U3D4-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_050674"/>
        </isoform>
        <isoform>
            <id>Q9U3D4-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.8.27" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001129861.2">
        <property type="nucleotide sequence ID" value="NM_001136389.4"/>
    </dbReference>
    <dbReference type="WormBase" id="H21P03.3c">
        <property type="protein sequence ID" value="CE44516"/>
        <property type="gene ID" value="WBGene00004892"/>
        <property type="gene designation" value="sms-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="14685263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="14685263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="352" mass="40003" checksum="D1A0AFB356142E59" modified="2010-10-05" version="2">MDDDDIITTARSSSRRICGSAASSSDSETADDAPLLPDEGPSHAVRLEMPGDKPASPHDRFPKTPLKTLVAFLMLVVAAAGNTITLSWIHERYPLTPPLPDIVFELIPKIPWGLRLCENLMIGSFVSLLVLILFHRHRWIVLRRLCFIGSILYGMRCITMMVTPVPKADEDFECSPRFGENATFSLIVMRGVWSMFGLGLNLFDNQKVVLCGDYIYSGHTLVLVVSALFIGEYSPRRFYILHWLSWLVCSVGVIFLVLSHGHYTIDVILSYFACTRVFWAYHTQAAHPSIRLSVQNHQAKEFWFPLLRWFEGDIRRPVPRRFDCPISYSQVCNAFRRVRPRGRNGAARPAFE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-01" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q9U3D4-4</accession>
    <name>SMS1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform d of Phosphatidylcholine:ceramide cholinephosphotransferase 1</fullName>
            <shortName evidence="2">PC:ceramide cholinephosphotransferase 1</shortName>
            <ecNumber evidence="1">2.7.8.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Sphingomyelin synthase 1</fullName>
            <shortName evidence="2">CSS3alpha1</shortName>
            <shortName evidence="2">SMS-1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sms-1</name>
        <name type="ORF">H21P03.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2004" name="EMBO J." volume="23" first="33" last="44">
            <title>Identification of a family of animal sphingomyelin synthases.</title>
            <authorList>
                <person name="Huitema K."/>
                <person name="Van Den Dikkenberg J."/>
                <person name="Brouwers J.F.H.M."/>
                <person name="Holthuis J.C."/>
            </authorList>
            <dbReference type="PubMed" id="14685263"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600034"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9U3D4-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_050674"/>
        </isoform>
        <isoform>
            <id>Q9U3D4-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_039807"/>
        </isoform>
        <isoform>
            <id>Q9U3D4-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_061062"/>
        </isoform>
        <isoform>
            <id>Q9U3D4-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.8.27" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001255559.1">
        <property type="nucleotide sequence ID" value="NM_001268630.3"/>
    </dbReference>
    <dbReference type="WormBase" id="H21P03.3d">
        <property type="protein sequence ID" value="CE46610"/>
        <property type="gene ID" value="WBGene00004892"/>
        <property type="gene designation" value="sms-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="14685263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="14685263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="415" mass="46747" checksum="B5CE0880EF096387" modified="2010-10-05" version="2">MQDDNGDEEKAENSEGAAAEKVEKQHDDDGVVVHEETDGVASSRSSHHDKQKPGETKKSGDGKMDDDDIITTARSSSRRICGSAASSSDSETADDAPLLPDEGPSHAVRLEMPGDKPASPHDRFPKTPLKTLVAFLMLVVAAAGNTITLSWIHERYPLTPPLPDIVFELIPKIPWGLRLCENLMIGSFVSLLVLILFHRHRWIVLRRLCFIGSILYGMRCITMMVTPVPKADEDFECSPRFGENATFSLIVMRGVWSMFGLGLNLFDNQKVVLCGDYIYSGHTLVLVVSALFIGEYSPRRFYILHWLSWLVCSVGVIFLVLSHGHYTIDVILSYFACTRVFWAYHTQAAHPSIRLSVQNHQAKEFWFPLLRWFEGDIRRPVPRRFDCPISYSQVCNAFRRVRPRGRNGAARPAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEG1</accession>
    <name>U4PEG1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbon storage regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C23H5.11</name>
        <name evidence="1" type="ORF">CELE_C23H5.11</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368242.1">
        <property type="nucleotide sequence ID" value="NM_001380083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEG1"/>
    <dbReference type="GeneID" id="4363072"/>
    <dbReference type="AGR" id="WB:WBGene00044649"/>
    <dbReference type="CTD" id="4363072"/>
    <dbReference type="WormBase" id="C23H5.11b">
        <property type="protein sequence ID" value="CE48853"/>
        <property type="gene ID" value="WBGene00044649"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_710262_0_0_1"/>
    <dbReference type="OrthoDB" id="5807489at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044649">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C23H5.11b"/>
        </source>
    </evidence>
    <sequence length="39" mass="4683" checksum="3CE3CCABE59F96DF" modified="2013-12-11" version="1">MRSYLRDDAVYRVRFAIPQQIVQIIQEEDVSDENTIFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEG5</accession>
    <name>U4PEG5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DENN domain type RAB GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">denn-4</name>
        <name evidence="6" type="ORF">CELE_F52C12.4</name>
        <name evidence="8" type="ORF">F52C12.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294385.1">
        <property type="nucleotide sequence ID" value="NM_001307456.3"/>
    </dbReference>
    <dbReference type="SMR" id="U4PEG5"/>
    <dbReference type="GeneID" id="186100"/>
    <dbReference type="AGR" id="WB:WBGene00018681"/>
    <dbReference type="CTD" id="186100"/>
    <dbReference type="WormBase" id="F52C12.4b">
        <property type="protein sequence ID" value="CE49059"/>
        <property type="gene ID" value="WBGene00018681"/>
        <property type="gene designation" value="denn-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75250at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018681">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEG5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
    <sequence length="54" mass="6265" checksum="816C5B0422550C7E" modified="2013-12-11" version="1">MIRSWEMGVLITDPSRFNIPFDYPLVPYSATDEPFVTDKKHEKPDILGCIWTPP</sequence>
</entry>
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        <property type="entry name" value="Smg8_Smg9"/>
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        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH93131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="K04B12.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="U4PEH8"/>
        </source>
    </evidence>
    <sequence length="871" mass="99729" checksum="7EF13EE80FE24A5F" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEI2</accession>
    <name>U4PEI2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">egrh-2</name>
        <name evidence="8" type="ORF">CELE_Y55F3AM.7</name>
        <name evidence="10" type="ORF">Y55F3AM.7</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294399.1">
        <property type="nucleotide sequence ID" value="NM_001307470.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEI2"/>
    <dbReference type="SMR" id="U4PEI2"/>
    <dbReference type="GeneID" id="190308"/>
    <dbReference type="KEGG" id="cel:CELE_Y55F3AM.7"/>
    <dbReference type="AGR" id="WB:WBGene00043705"/>
    <dbReference type="CTD" id="190308"/>
    <dbReference type="WormBase" id="Y55F3AM.7a">
        <property type="protein sequence ID" value="CE48669"/>
        <property type="gene ID" value="WBGene00043705"/>
        <property type="gene designation" value="egrh-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00043705">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEI2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004527">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000926">
        <property type="entry name" value="Kruppel like factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF60">
        <property type="entry name" value="STRIPE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDH93136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y55F3AM.7a"/>
        </source>
    </evidence>
    <sequence length="283" mass="32105" checksum="A0E313A8DA349E53" modified="2013-12-11" version="1">MNIDGTPKANGFFGFPPQTAETKLKDLLGNISFGVPINGNNEQKSEELKLKDIEISSTGPSGLDSPGLSAAMFQFSPMVEHLLQNLTNKAGVPESVVDSKTVGLNYQEPSDSKTHTSFSDSASLAHFELKTEPMDDYSYNFSDNDFNSFKFSSTPEEPKNIGCQKMKSSKMHLQDRPYKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICMRRFSRSDHLTTHVRTHTGEKPYSCDICGKKFARCDERTRHTKIHKKSQRSGSRQAQDEVWSSMEDPMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEI7</accession>
    <name>U4PEI7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_Y55F3AM.9</name>
        <name evidence="5 7" type="ORF">Y55F3AM.9</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MINDY deubiquitinase family. FAM63 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEI7"/>
    <dbReference type="SMR" id="U4PEI7"/>
    <dbReference type="PeptideAtlas" id="U4PEI7"/>
    <dbReference type="AGR" id="WB:WBGene00021926"/>
    <dbReference type="WormBase" id="Y55F3AM.9b">
        <property type="protein sequence ID" value="CE48571"/>
        <property type="gene ID" value="WBGene00021926"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022566_5_0_1"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021926">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEI7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140934">
        <property type="term" value="F:histone deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y55F3AM.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="U4PEI7"/>
        </source>
    </evidence>
    <sequence length="177" mass="19406" checksum="3E896A794D3C08FB" modified="2013-12-11" version="1">MCGDQSTETELLRTFYDESISQITFHGLASLMERMKDGELAVVFHNNHFSTILKRRDEIFKLVSDEGLCDEPNIVWETFSSVDGDCIFVNGDFGNFKPITPPTTHPSPESFEKLQISDNSPIEQGIEAVEHTSAHHSAPVSPQHRAPAPPAPQTARAPPETSPTRNSGAGGKSCLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEJ2</accession>
    <name>U4PEJ2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">unc-49</name>
        <name evidence="2" type="ORF">CELE_T21C12.1</name>
        <name evidence="4" type="ORF">T21C12.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDH93146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293662.1">
        <property type="nucleotide sequence ID" value="NM_001306733.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEJ2"/>
    <dbReference type="SMR" id="U4PEJ2"/>
    <dbReference type="GeneID" id="176472"/>
    <dbReference type="AGR" id="WB:WBGene00006784"/>
    <dbReference type="CTD" id="176472"/>
    <dbReference type="WormBase" id="T21C12.1n">
        <property type="protein sequence ID" value="CE48682"/>
        <property type="gene ID" value="WBGene00006784"/>
        <property type="gene designation" value="unc-49"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010920_0_2_1"/>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006784">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEJ2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T21C12.1n"/>
        </source>
    </evidence>
    <sequence length="75" mass="9003" checksum="A15AB343D499094B" modified="2013-12-11" version="1">MLGRSNSQASVFLYQTAVISDDEFGRFWRWLRPSNIDKYSRSLFPSIFVLFNVGYWAYFIRQSQIQEEQRNSQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEK0</accession>
    <name>U4PEK0_CAEEL</name>
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        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">spsb-1</name>
        <name evidence="5" type="ORF">CELE_Y46E12BL.4</name>
        <name evidence="7" type="ORF">Y46E12BL.4</name>
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    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPSB family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDH93156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001377910.2"/>
    </dbReference>
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    <dbReference type="AGR" id="WB:WBGene00021597"/>
    <dbReference type="CTD" id="266876"/>
    <dbReference type="WormBase" id="Y46E12BL.4e">
        <property type="protein sequence ID" value="CE48902"/>
        <property type="gene ID" value="WBGene00021597"/>
        <property type="gene designation" value="spsb-1"/>
    </dbReference>
    <dbReference type="OMA" id="SESYGWD"/>
    <dbReference type="OrthoDB" id="5547302at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021597">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEK0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="entry name" value="SOCS_SSB1_4"/>
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    </dbReference>
    <dbReference type="CDD" id="cd12906">
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    </dbReference>
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        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
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    </dbReference>
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        <property type="entry name" value="SplA/ryanodine receptor domain and SOCS box containing 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN GUSTAVUS"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="174"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="360"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y46E12BL.4e"/>
        </source>
    </evidence>
    <sequence length="413" mass="46296" checksum="83F740DE051D05C5" modified="2013-12-11" version="1">MMGPGEEEEEQLFDTTPEGSEDDDYDMVMYDESSADSSFSVPTSTVPSSVAETYETMDTDAGFSTDSEMERLVELRSVSPSSDACSTSSSTYARPAAAAHSAGNNSSSSSSNAGGGDGYHRSNSSGSSTRPVAATRERKSYAVAAGRSAPMRSLSPAHPSAVLQMSGMDDFLRPDRFDRIMQMTKPDQFIQEQHSWNPEDRSLNIFVKDEDKFTFHRHPVAQSTDCIRGKMGYSRGFHVWQIEWPERQRGTHAVVGVATKNAPLHAAGYTALIGTTDESYGWDITRRECHHDSKHTMTWRYPFSNSRDVYNVPDKFYCILDMDEGYMAFATDDEFLGVAFRNLKGKTLYPIVAAVWGHCEISMRYLGSLEPEPLSLSELCRRRVRIEMGAQPEDHIEQLMIPPILKRYLMYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEK5</accession>
    <name>U4PEK5_CAEEL</name>
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        <submittedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">cdh-8</name>
        <name evidence="12" type="ORF">CELE_F18F11.3</name>
        <name evidence="14" type="ORF">F18F11.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001307480.3"/>
    </dbReference>
    <dbReference type="SMR" id="U4PEK5"/>
    <dbReference type="GeneID" id="184652"/>
    <dbReference type="AGR" id="WB:WBGene00017576"/>
    <dbReference type="CTD" id="184652"/>
    <dbReference type="WormBase" id="F18F11.3a">
        <property type="protein sequence ID" value="CE48879"/>
        <property type="gene ID" value="WBGene00017576"/>
        <property type="gene designation" value="cdh-8"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799622at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017576">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEK5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="12"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
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        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
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    </dbReference>
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        <property type="entry name" value="CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="CADHERIN_2"/>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
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    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652814" evidence="10">
        <location>
            <begin position="23"/>
            <end position="1653"/>
        </location>
    </feature>
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        <location>
            <begin position="1567"/>
            <end position="1587"/>
        </location>
    </feature>
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        <location>
            <begin position="54"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="126"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="454"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="549"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="779"/>
            <end position="854"/>
        </location>
    </feature>
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        <location>
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            <end position="956"/>
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    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="958"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1239"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1365"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1629"/>
            <end position="1653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDH93161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F18F11.3a"/>
        </source>
    </evidence>
    <sequence length="1653" mass="182158" checksum="D6C6EE159A76BEBF" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDH93176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293670.1">
        <property type="nucleotide sequence ID" value="NM_001306741.3"/>
    </dbReference>
    <dbReference type="SMR" id="U4PEM0"/>
    <dbReference type="GeneID" id="175783"/>
    <dbReference type="AGR" id="WB:WBGene00003918"/>
    <dbReference type="CTD" id="175783"/>
    <dbReference type="WormBase" id="F54E7.3j">
        <property type="protein sequence ID" value="CE48658"/>
        <property type="gene ID" value="WBGene00003918"/>
        <property type="gene designation" value="par-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264899at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003918">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEM0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23059">
        <property type="entry name" value="PDZ3_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Partitioning defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Partitioning defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000291">
        <property type="entry name" value="Partitioning defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021922">
        <property type="entry name" value="Par3/HAL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF17">
        <property type="entry name" value="BAZOOKA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12053">
        <property type="entry name" value="Par3_HAL_N_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="381"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="515"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="659"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="767"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="933"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1221"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1298"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="798"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="828"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="854"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="978"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1238"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDH93176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F54E7.3j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="U4PEM0"/>
        </source>
    </evidence>
    <sequence length="1327" mass="143758" checksum="AD7C8CA7B020AC62" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEM4</accession>
    <name>U4PEM4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pash-1</name>
        <name evidence="2" type="ORF">CELE_T22A3.5</name>
        <name evidence="4" type="ORF">T22A3.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDH93181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293462.1">
        <property type="nucleotide sequence ID" value="NM_001306533.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEM4"/>
    <dbReference type="SMR" id="U4PEM4"/>
    <dbReference type="PeptideAtlas" id="U4PEM4"/>
    <dbReference type="GeneID" id="172950"/>
    <dbReference type="AGR" id="WB:WBGene00011908"/>
    <dbReference type="CTD" id="172950"/>
    <dbReference type="WormBase" id="T22A3.5b">
        <property type="protein sequence ID" value="CE48740"/>
        <property type="gene ID" value="WBGene00011908"/>
        <property type="gene designation" value="pash-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021062_0_0_1"/>
    <dbReference type="OrthoDB" id="112668at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011908">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEM4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000021">
        <property type="entry name" value="Microprocessor complex subunit DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040375">
        <property type="entry name" value="DGCR8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482:SF3">
        <property type="entry name" value="MICROPROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482">
        <property type="entry name" value="MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T22A3.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PEM4"/>
        </source>
    </evidence>
    <sequence length="265" mass="29788" checksum="C33E8CA7BD44C809" modified="2013-12-11" version="1">MVEEDGTQQGFEELFKKVKIDSPNLVQMCTQCAIPKPYNLLRDAVSRSLRWNGMELVMKKEMIGNGSQLSKVILILGDIQEEAEAVGVKQATQMASQRLFKKMHPELLTYGSFLEIYGRLDDKSKIDNAKKQHDEVVRLPDTGNLLAPNFIVLSKLSEEMKNISLVYPPRKFLYGLATNSTGIKHDIRNVLTQTLMATLPPPPPQFFPMIGGPPLMHPTFSTSAPPPPPPPQPMEYGYNPMKQMPSRKRGRHDDSSSPSHQKPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>W6RTM2</accession>
    <name>W6RTM2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">herc-1</name>
        <name evidence="7" type="ORF">CELE_Y48G8AL.1</name>
        <name evidence="9" type="ORF">Y48G8AL.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001427162.1">
        <property type="nucleotide sequence ID" value="NM_001440229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RTM2"/>
    <dbReference type="SMR" id="W6RTM2"/>
    <dbReference type="PeptideAtlas" id="W6RTM2"/>
    <dbReference type="GeneID" id="171700"/>
    <dbReference type="AGR" id="WB:WBGene00021685"/>
    <dbReference type="CTD" id="171700"/>
    <dbReference type="WormBase" id="Y48G8AL.1d">
        <property type="protein sequence ID" value="CE49556"/>
        <property type="gene ID" value="WBGene00021685"/>
        <property type="gene designation" value="herc-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_5_3_1"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021685">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RTM2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="173"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM63558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y48G8AL.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="W6RTM2"/>
        </source>
    </evidence>
    <sequence length="504" mass="58243" checksum="0560EDC2EF8845BC" modified="2014-04-16" version="1">MCLITGDLRAALEKWWTQLSTRHFRRMVTVFKTAIKAMLKAKKGPRDCHKFILIMQKLSLINKTYHIIPLETFYIDELNTSVDLKLEYVLELTRQDPNKTELDYWTHFPFLLNGVAKGELIFVEAWLMQTLRRQSSLFNTAHGTIIFELPHLELTVRREFIVSDTMNQMAGLSESDLQKPLKVNIAGEDADDAGGVRKEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPSEFCDREQFHQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDDVEDVFGLNFCISFNILGETHTTELLSGGTEKPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMYRGEYSSSHPTIQAFWKAFFALTDDERRKFLQFLTGSTRIPVSGWEELHAAIQPSAPESLPVAHTCFNLLDLPNIADDVELLRRLRISIEHTEGFTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6RTM8</accession>
    <name>W6RTM8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C06A6.2</name>
        <name evidence="2" type="ORF">CELE_C06A6.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294197.1">
        <property type="nucleotide sequence ID" value="NM_001307268.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RTM8"/>
    <dbReference type="SMR" id="W6RTM8"/>
    <dbReference type="GeneID" id="177573"/>
    <dbReference type="AGR" id="WB:WBGene00015507"/>
    <dbReference type="CTD" id="177573"/>
    <dbReference type="WormBase" id="C06A6.2e">
        <property type="protein sequence ID" value="CE49562"/>
        <property type="gene ID" value="WBGene00015507"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_980822_0_0_1"/>
    <dbReference type="OrthoDB" id="5854136at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015507">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RTM8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM63563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C06A6.2e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="W6RTM8"/>
        </source>
    </evidence>
    <sequence length="284" mass="31112" checksum="436D2ED643525B72" modified="2014-04-16" version="1">MAASSPSTAFIGMPTTINGNKSIQTVLDNLIAARSKKEDHAASTTSVLQAPNYSELKQMLEKNNILKVDNENGPPLKRVKQEIESPPGSSRMIVYNDTRKTTNAPISTWVPPREDLTAKVKDETVQSVPQRKAQATAVIKSGFPLEKHLKKMIQQAVPSMIPVTSSSIPQRNGILGLNSMILPPSAIQQALLKKMDVPTTTPSMSSTSSSQAQSSMNGVINGNNTEVEDKWTLLGRMIAMMAREIETRDPMSACELTRDLQQVIFQYNMKTLRPKENNSSSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>W6RTN2</accession>
    <name>W6RTN2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-GEF domain-containing family member 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_R05G6.10</name>
        <name evidence="7 9" type="ORF">R05G6.10</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294202.1">
        <property type="nucleotide sequence ID" value="NM_001307273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RTN2"/>
    <dbReference type="SMR" id="W6RTN2"/>
    <dbReference type="GeneID" id="177527"/>
    <dbReference type="AGR" id="WB:WBGene00019902"/>
    <dbReference type="CTD" id="177527"/>
    <dbReference type="WormBase" id="R05G6.10d">
        <property type="protein sequence ID" value="CE49577"/>
        <property type="gene ID" value="WBGene00019902"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20825at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019902">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RTN2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF356">
        <property type="entry name" value="FI05912P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="101"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="268"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM63568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="R05G6.10d"/>
        </source>
    </evidence>
    <sequence length="532" mass="60330" checksum="3CE8064B955F17BC" modified="2014-04-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W6RTQ3</accession>
    <name>W6RTQ3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">pmk-3</name>
        <name evidence="13" type="ORF">CELE_F42G8.4</name>
        <name evidence="15" type="ORF">F42G8.4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294205.1">
        <property type="nucleotide sequence ID" value="NM_001307276.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RTQ3"/>
    <dbReference type="SMR" id="W6RTQ3"/>
    <dbReference type="PeptideAtlas" id="W6RTQ3"/>
    <dbReference type="GeneID" id="177610"/>
    <dbReference type="KEGG" id="cel:CELE_F42G8.4"/>
    <dbReference type="AGR" id="WB:WBGene00004057"/>
    <dbReference type="CTD" id="177610"/>
    <dbReference type="WormBase" id="F42G8.4b">
        <property type="protein sequence ID" value="CE49573"/>
        <property type="gene ID" value="WBGene00004057"/>
        <property type="gene designation" value="pmk-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004057">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RTQ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000684">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM63593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F42G8.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="W6RTQ3"/>
        </source>
    </evidence>
    <sequence length="300" mass="35050" checksum="62890E2775268183" modified="2014-04-16" version="1">MRHDNIICALDIYTPDEENDFRDVYVVTEFAGRSLYQILKQQRDYGRRVLTDEHIKFIIYQIIRALKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLEKKDTSLTQYVQTRWYRSPEVIYWKIDSYTNLADMWSLGCIAAELLTGEPLFPGDEPNAQYQRITQLCGSPDEELLTKIENDNSSAIKAVIQSYTTHKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPEKRITVEEAIQHPYLAEFSLPEDEPRADHIFDLDDSQARTRFEWRDAVWKEIMNYKRLSSSPLIPGEADR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>X5M5N0-10</accession>
    <name>WNK_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform i of Serine/threonine-protein kinase WNK</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein kinase with no lysine 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">wnk-1</name>
        <name evidence="18" type="ORF">C46C2.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Choe K.P."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="70" last="75">
            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="18049475"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
            <authorList>
                <person name="Lee E.C."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
            <authorList>
                <person name="Boyd-Shiwarski C.R."/>
                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
            </authorList>
            <dbReference type="PubMed" id="36318922"/>
            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>X5M5N0-19</id>
            <name evidence="23">s</name>
            <sequence type="described" ref="VSP_057685 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-8</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_057685 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-2</id>
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            <sequence type="described" ref="VSP_057688 VSP_057685 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-4</id>
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        </isoform>
        <isoform>
            <id>X5M5N0-16</id>
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            <sequence type="described" ref="VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-14</id>
            <name evidence="17">m</name>
            <sequence type="described" ref="VSP_057686 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-18</id>
            <name evidence="22">r</name>
            <sequence type="described" ref="VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-21</id>
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            <sequence type="described" ref="VSP_057683 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-5</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_057686 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-15</id>
            <name evidence="19">o</name>
            <sequence type="described" ref="VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-20</id>
            <name evidence="24">t</name>
            <sequence type="described" ref="VSP_057685 VSP_057687 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-13</id>
            <name evidence="16">l</name>
            <sequence type="described" ref="VSP_057684 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-12</id>
            <name evidence="15">k</name>
            <sequence type="described" ref="VSP_057688 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-22</id>
            <name evidence="26">v</name>
            <sequence type="described" ref="VSP_057683"/>
        </isoform>
        <isoform>
            <id>X5M5N0-3</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_057685 VSP_057688 VSP_057687 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-17</id>
            <name evidence="21">q</name>
            <sequence type="described" ref="VSP_057687 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-1</id>
            <name evidence="18">n</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>X5M5N0-11</id>
            <name evidence="14">j</name>
            <sequence type="described" ref="VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-10</id>
            <name evidence="13">i</name>
            <sequence type="described" ref="VSP_057685 VSP_057684 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-9</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_057687 VSP_057685 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-6</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_057688 VSP_057686 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-7</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_057688 VSP_057686 VSP_057684"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001255376.1">
        <property type="nucleotide sequence ID" value="NM_001268447.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C46C2.1i">
        <property type="protein sequence ID" value="CE46749"/>
        <property type="gene ID" value="WBGene00006941"/>
        <property type="gene designation" value="wnk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="17596296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C46C2.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C46C2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C46C2.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C46C2.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="C46C2.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="C46C2.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="C46C2.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="C46C2.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="C46C2.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="C46C2.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="C46C2.1k"/>
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    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="C46C2.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="C46C2.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="C46C2.1n"/>
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    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
            <dbReference type="WormBase" id="C46C2.1p"/>
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    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
            <dbReference type="WormBase" id="C46C2.1q"/>
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    </evidence>
    <evidence type="ECO:0000312" key="22">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="23">
        <source>
            <dbReference type="WormBase" id="C46C2.1s"/>
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    </evidence>
    <evidence type="ECO:0000312" key="24">
        <source>
            <dbReference type="WormBase" id="C46C2.1t"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="25">
        <source>
            <dbReference type="WormBase" id="C46C2.1u"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="26">
        <source>
            <dbReference type="WormBase" id="C46C2.1v"/>
        </source>
    </evidence>
    <sequence length="1788" mass="193132" checksum="BFB11719017E47C0" modified="2014-06-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>X5M5N0-11</accession>
    <name>WNK_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform j of Serine/threonine-protein kinase WNK</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein kinase with no lysine 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">wnk-1</name>
        <name evidence="18" type="ORF">C46C2.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
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            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
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            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
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                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
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            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
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        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
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                <person name="Lee E.C."/>
                <person name="Strange K."/>
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            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
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                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
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            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
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        <scope>ACTIVITY REGULATION</scope>
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            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
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            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
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                <person name="Moriguchi T."/>
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            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
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            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
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                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
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            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
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        <scope>ACTIVITY REGULATION</scope>
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        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="22">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="23">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="24">
        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000312" key="26">
        <source>
            <dbReference type="WormBase" id="C46C2.1v"/>
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    <sequence length="1682" mass="182439" checksum="18DDA946DE44D3DA" modified="2014-06-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
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    <organism>
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            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Choe K.P."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="70" last="75">
            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="18049475"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
            <authorList>
                <person name="Lee E.C."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
            <authorList>
                <person name="Boyd-Shiwarski C.R."/>
                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
            </authorList>
            <dbReference type="PubMed" id="36318922"/>
            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
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        <event type="alternative splicing"/>
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    </comment>
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</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
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    <organism>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Choe K.P."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="70" last="75">
            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="18049475"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
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            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
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                <person name="Strange K."/>
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            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
            <authorList>
                <person name="Boyd-Shiwarski C.R."/>
                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
            </authorList>
            <dbReference type="PubMed" id="36318922"/>
            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
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        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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            <strain evidence="4">Bristol N2</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
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            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
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        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
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                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
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            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
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        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
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    <reference evidence="2" key="4">
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            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
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            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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        <scope>FUNCTION</scope>
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    <reference key="5">
        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
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                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
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            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
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        <scope>ACTIVITY REGULATION</scope>
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            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
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                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
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            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
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        <scope>ACTIVITY REGULATION</scope>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
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            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
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                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
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        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
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            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
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                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
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            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
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            <sequence type="described" ref="VSP_057685 VSP_057686 VSP_057687 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_057688 VSP_057686 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-11</id>
            <name evidence="14">j</name>
            <sequence type="described" ref="VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-4</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_057685 VSP_057688 VSP_057686 VSP_057684"/>
        </isoform>
        <isoform>
            <id>X5M5N0-19</id>
            <name evidence="23">s</name>
            <sequence type="described" ref="VSP_057687 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-6</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_057688 VSP_057686 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-22</id>
            <name evidence="26">v</name>
            <sequence type="described" ref="VSP_057683"/>
        </isoform>
        <isoform>
            <id>X5M5N0-17</id>
            <name evidence="21">q</name>
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        </isoform>
        <isoform>
            <id>X5M5N0-15</id>
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            <sequence type="described" ref="VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-20</id>
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            <sequence type="described" ref="VSP_057685 VSP_057686 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-13</id>
            <name evidence="16">l</name>
            <sequence type="described" ref="VSP_057688 VSP_057684"/>
        </isoform>
        <isoform>
            <id>X5M5N0-1</id>
            <name evidence="18">n</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>X5M5N0-16</id>
            <name evidence="20">p</name>
            <sequence type="described" ref="VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-5</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_057686 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-9</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_057687 VSP_057685 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-14</id>
            <name evidence="17">m</name>
            <sequence type="described" ref="VSP_057685 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-18</id>
            <name evidence="22">r</name>
            <sequence type="described" ref="VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-8</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_057685 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-7</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_057688 VSP_057684 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-12</id>
            <name evidence="15">k</name>
            <sequence type="described" ref="VSP_057687 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-21</id>
            <name evidence="25">u</name>
            <sequence type="described" ref="VSP_057688 VSP_057683"/>
        </isoform>
        <isoform>
            <id>X5M5N0-10</id>
            <name evidence="13">i</name>
            <sequence type="described" ref="VSP_057688 VSP_057685 VSP_057684"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001294035.1">
        <property type="nucleotide sequence ID" value="NM_001307106.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C46C2.1q">
        <property type="protein sequence ID" value="CE49684"/>
        <property type="gene ID" value="WBGene00006941"/>
        <property type="gene designation" value="wnk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="17596296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C46C2.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C46C2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C46C2.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C46C2.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="C46C2.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="C46C2.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="C46C2.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="C46C2.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="C46C2.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="C46C2.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="C46C2.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="C46C2.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="C46C2.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="C46C2.1n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="C46C2.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
            <dbReference type="WormBase" id="C46C2.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
            <dbReference type="WormBase" id="C46C2.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="22">
        <source>
            <dbReference type="WormBase" id="C46C2.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="23">
        <source>
            <dbReference type="WormBase" id="C46C2.1s"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="24">
        <source>
            <dbReference type="WormBase" id="C46C2.1t"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="25">
        <source>
            <dbReference type="WormBase" id="C46C2.1u"/>
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    </evidence>
    <evidence type="ECO:0000312" key="26">
        <source>
            <dbReference type="WormBase" id="C46C2.1v"/>
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    </evidence>
    <sequence length="1686" mass="182240" checksum="21524E573AD6D48C" modified="2014-06-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>X5M5N0-18</accession>
    <name>WNK_CAEEL</name>
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        <recommendedName>
            <fullName evidence="2">Isoform r of Serine/threonine-protein kinase WNK</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein kinase with no lysine 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">wnk-1</name>
        <name evidence="18" type="ORF">C46C2.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Choe K.P."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="70" last="75">
            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="18049475"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
            <authorList>
                <person name="Lee E.C."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
            <authorList>
                <person name="Boyd-Shiwarski C.R."/>
                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
            </authorList>
            <dbReference type="PubMed" id="36318922"/>
            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>X5M5N0-19</id>
            <name evidence="23">s</name>
            <sequence type="described" ref="VSP_057687 VSP_057685"/>
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        <isoform>
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        <isoform>
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        <isoform>
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        <isoform>
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        <isoform>
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        <isoform>
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        <isoform>
            <id>X5M5N0-12</id>
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        <isoform>
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        <isoform>
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        <isoform>
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        <isoform>
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        <isoform>
            <id>X5M5N0-6</id>
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        </isoform>
        <isoform>
            <id>X5M5N0-2</id>
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        <isoform>
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        <isoform>
            <id>X5M5N0-11</id>
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        <isoform>
            <id>X5M5N0-9</id>
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        </isoform>
        <isoform>
            <id>X5M5N0-14</id>
            <name evidence="17">m</name>
            <sequence type="described" ref="VSP_057685 VSP_057686"/>
        </isoform>
    </comment>
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        <property type="gene designation" value="wnk-1"/>
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            <dbReference type="PubMed" id="18049475"/>
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    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="17596296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C46C2.1a"/>
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    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C46C2.1b"/>
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    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C46C2.1c"/>
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    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C46C2.1d"/>
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    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="C46C2.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="C46C2.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="C46C2.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="C46C2.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="C46C2.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="C46C2.1j"/>
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    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="C46C2.1k"/>
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    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="C46C2.1l"/>
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    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="C46C2.1m"/>
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    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
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    <evidence type="ECO:0000312" key="20">
        <source>
            <dbReference type="WormBase" id="C46C2.1p"/>
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    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="22">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="23">
        <source>
            <dbReference type="WormBase" id="C46C2.1s"/>
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    </evidence>
    <evidence type="ECO:0000312" key="24">
        <source>
            <dbReference type="WormBase" id="C46C2.1t"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="25">
        <source>
            <dbReference type="WormBase" id="C46C2.1u"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="26">
        <source>
            <dbReference type="WormBase" id="C46C2.1v"/>
        </source>
    </evidence>
    <sequence length="1848" mass="198938" checksum="17E7E740F2FB49ED" modified="2014-06-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>X5M5N0-19</accession>
    <name>WNK_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform s of Serine/threonine-protein kinase WNK</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein kinase with no lysine 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">wnk-1</name>
        <name evidence="18" type="ORF">C46C2.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Choe K.P."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="70" last="75">
            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="18049475"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
            <authorList>
                <person name="Lee E.C."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
            <authorList>
                <person name="Boyd-Shiwarski C.R."/>
                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
            </authorList>
            <dbReference type="PubMed" id="36318922"/>
            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>X5M5N0-7</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_057688 VSP_057686 VSP_057684"/>
        </isoform>
        <isoform>
            <id>X5M5N0-15</id>
            <name evidence="19">o</name>
            <sequence type="described" ref="VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_057686 VSP_057685 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-17</id>
            <name evidence="21">q</name>
            <sequence type="described" ref="VSP_057687 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-16</id>
            <name evidence="20">p</name>
            <sequence type="described" ref="VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-1</id>
            <name evidence="18">n</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>X5M5N0-18</id>
            <name evidence="22">r</name>
            <sequence type="described" ref="VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-6</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_057688 VSP_057687 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-10</id>
            <name evidence="13">i</name>
            <sequence type="described" ref="VSP_057688 VSP_057685 VSP_057684"/>
        </isoform>
        <isoform>
            <id>X5M5N0-8</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_057685 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-22</id>
            <name evidence="26">v</name>
            <sequence type="described" ref="VSP_057683"/>
        </isoform>
        <isoform>
            <id>X5M5N0-13</id>
            <name evidence="16">l</name>
            <sequence type="described" ref="VSP_057684 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-3</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_057687 VSP_057686 VSP_057688 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-12</id>
            <name evidence="15">k</name>
            <sequence type="described" ref="VSP_057687 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-11</id>
            <name evidence="14">j</name>
            <sequence type="described" ref="VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-9</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_057685 VSP_057687 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-21</id>
            <name evidence="25">u</name>
            <sequence type="described" ref="VSP_057688 VSP_057683"/>
        </isoform>
        <isoform>
            <id>X5M5N0-19</id>
            <name evidence="23">s</name>
            <sequence type="described" ref="VSP_057687 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-5</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_057688 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-20</id>
            <name evidence="24">t</name>
            <sequence type="described" ref="VSP_057685 VSP_057687 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-4</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_057688 VSP_057686 VSP_057684 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-14</id>
            <name evidence="17">m</name>
            <sequence type="described" ref="VSP_057686 VSP_057685"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001294037.1">
        <property type="nucleotide sequence ID" value="NM_001307108.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C46C2.1s">
        <property type="protein sequence ID" value="CE49622"/>
        <property type="gene ID" value="WBGene00006941"/>
        <property type="gene designation" value="wnk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="17596296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C46C2.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C46C2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C46C2.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C46C2.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="C46C2.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="C46C2.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="C46C2.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="C46C2.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="C46C2.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="C46C2.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="C46C2.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="C46C2.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="C46C2.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="C46C2.1n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="C46C2.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
            <dbReference type="WormBase" id="C46C2.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
            <dbReference type="WormBase" id="C46C2.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="22">
        <source>
            <dbReference type="WormBase" id="C46C2.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="23">
        <source>
            <dbReference type="WormBase" id="C46C2.1s"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="24">
        <source>
            <dbReference type="WormBase" id="C46C2.1t"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="25">
        <source>
            <dbReference type="WormBase" id="C46C2.1u"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="26">
        <source>
            <dbReference type="WormBase" id="C46C2.1v"/>
        </source>
    </evidence>
    <sequence length="1687" mass="182343" checksum="28544B3FBD12F9A6" modified="2014-06-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BS14</accession>
    <name>A0A078BS14_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Frizzled-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">lin-17</name>
        <name evidence="14" type="ORF">CELE_Y71F9B.5</name>
        <name evidence="16" type="ORF">Y71F9B.5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293367.1">
        <property type="nucleotide sequence ID" value="NM_001306438.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BS14"/>
    <dbReference type="SMR" id="A0A078BS14"/>
    <dbReference type="GeneID" id="171832"/>
    <dbReference type="AGR" id="WB:WBGene00003006"/>
    <dbReference type="CTD" id="171832"/>
    <dbReference type="WormBase" id="Y71F9B.5c">
        <property type="protein sequence ID" value="CE50007"/>
        <property type="gene ID" value="WBGene00003006"/>
        <property type="gene designation" value="lin-17"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5959102at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003006">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BS14">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15909">
        <property type="entry name" value="7tmF_FZD4_9_10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000426">
        <property type="entry name" value="Transmembrane receptor LIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF99">
        <property type="entry name" value="FRIZZLED-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
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        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
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    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="136"/>
            <end position="428"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="454"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDX47416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="Y71F9B.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BS14"/>
        </source>
    </evidence>
    <sequence length="490" mass="54433" checksum="CD680AF8FD808FCA" modified="2014-10-29" version="1">MKTKCHPHIHFFICSVFAPMCPIGMPQAVTSCKSVCEQVKADCFSILEEFGIGWPEPLNCAQFPDPPELCMKPTEDEITGGFSAPRLPTKGSSSSSSKPTGCPSDLVDVDPHDPKSHCAFACQSNVMFSTDNKRMVRSWSIWFAAANAGVALFSFLTFAIDRKRFRFPERCVFYLSLCIFISSLPYLTPLFIDAPIRSCHALGNGRSYLSIGTFDNSYCLASFLLNYFFSTAAALWWLMFSFTLYLSGGRKWVPEGIEACSSYVHFVAWGLSSLATIIVLIFNKVDASELTALCSVGNLNSIALLWFVIVPRTICIVIGTCFIVGGFASMCRERISFRTRGTDTSKLEKLMVKMGFFCALFILPNVIELVCQCYKFMILTQWTRMTIDCKQQSGACHRPTPPQAEIYMTAVISSLATGFSCLMWVLSAKTVHAWKNFIFCGMCSSAPVKNPIEPSTRPLLEPPTAPPPQPPVYMQMATNPQNSWRPSKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BS18</accession>
    <name>A0A078BS18_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">ELRR (Extracellular Leucine-Rich Repeat) ONly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">lron-11</name>
        <name evidence="7" type="ORF">CELE_Y71F9B.8</name>
        <name evidence="9" type="ORF">Y71F9B.8</name>
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    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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    </dbReference>
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    <dbReference type="GeneID" id="171837"/>
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    <dbReference type="WormBase" id="Y71F9B.8e">
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        <property type="gene ID" value="WBGene00022129"/>
        <property type="gene designation" value="lron-11"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
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    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
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            <begin position="189"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDX47421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y71F9B.8e"/>
        </source>
    </evidence>
    <sequence length="241" mass="26539" checksum="F3234E9C2CA3D2E8" modified="2014-10-29" version="1">MATFVQLSSLHWLSISSSALTHIHPSAFNPIPPLSHLDLSNNELRYVAPGMLQWPNIRNLHLANNDWHCSCDLRVSNLNPRDDAKCSGPENLAGAPINELSSCSILGGLLIPFLLVLFILLLALVILALACKKSKPVSLKNRAFYNDQLIAALNSHKEYSFDCHSPYTMSSEDSRDSAYESPTSALMPRRPPPSCPPPPRLLTLPRAGPTHVAPPMVPVPNFRNSNDPYLIPKSQVPITRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BS22</accession>
    <name>A0A078BS22_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">dnj-30</name>
        <name evidence="2" type="ORF">CELE_Y71F9B.16</name>
        <name evidence="4" type="ORF">Y71F9B.16</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293377.1">
        <property type="nucleotide sequence ID" value="NM_001306448.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BS22"/>
    <dbReference type="SMR" id="A0A078BS22"/>
    <dbReference type="GeneID" id="171833"/>
    <dbReference type="KEGG" id="cel:CELE_Y71F9B.16"/>
    <dbReference type="AGR" id="WB:WBGene00001048"/>
    <dbReference type="CTD" id="171833"/>
    <dbReference type="WormBase" id="Y71F9B.16b">
        <property type="protein sequence ID" value="CE50074"/>
        <property type="gene ID" value="WBGene00001048"/>
        <property type="gene designation" value="dnj-30"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001048">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BS22">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y71F9B.16b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BS22"/>
        </source>
    </evidence>
    <sequence length="121" mass="14200" checksum="6586235754812395" modified="2014-10-29" version="1">MSEKKRKLRKDGKEDVIEEDDPAGYKKALWITVTKVFADREKKRKMLEERANEEKRRSTEALVQAAEKRKLAEEFAKNYEESRDERSGSWRNFQAKKAKKEDKGKTLKGAAFKPPKVKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BS27</accession>
    <name>A0A078BS27_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zc3h12a-like Ribonuclease NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">eri-9</name>
        <name evidence="5" type="ORF">C26E6.7</name>
        <name evidence="3" type="ORF">CELE_C26E6.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDX47431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293627.1">
        <property type="nucleotide sequence ID" value="NM_001306698.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BS27"/>
    <dbReference type="SMR" id="A0A078BS27"/>
    <dbReference type="GeneID" id="175665"/>
    <dbReference type="AGR" id="WB:WBGene00016143"/>
    <dbReference type="CTD" id="175665"/>
    <dbReference type="WormBase" id="C26E6.7d">
        <property type="protein sequence ID" value="CE24812"/>
        <property type="gene ID" value="WBGene00016143"/>
        <property type="gene designation" value="eri-9"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875795at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016143">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BS27">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028079">
        <property type="entry name" value="RNase_Zc3h12a_2"/>
    </dbReference>
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            <begin position="366"/>
            <end position="447"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C26E6.7d"/>
        </source>
    </evidence>
    <sequence length="664" mass="76735" checksum="79FF593D38FDA462" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BS31</accession>
    <name>A0A078BS31_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">CELE_Y51H4A.25</name>
        <name evidence="4 6" type="ORF">Y51H4A.25</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BS31"/>
    <dbReference type="SMR" id="A0A078BS31"/>
    <dbReference type="AGR" id="WB:WBGene00013119"/>
    <dbReference type="WormBase" id="Y51H4A.25d">
        <property type="protein sequence ID" value="CE50116"/>
        <property type="gene ID" value="WBGene00013119"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859488at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013119">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BS31">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001730427" evidence="2">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDX47436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y51H4A.25d"/>
        </source>
    </evidence>
    <sequence length="73" mass="7809" checksum="1D58C227F88EBE7F" modified="2014-10-29" version="1">MLQKTALIIGALSLIAGAFSDDCPSFFTKDDNGTCTIRQCLNGGYLDVSKQICICPSGYLGIHCEAGMYQIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BS36</accession>
    <name>A0A078BS36_CAEEL</name>
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        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="AGR" id="WB:WBGene00007635"/>
    <dbReference type="CTD" id="182684"/>
    <dbReference type="WormBase" id="C16D6.2c">
        <property type="protein sequence ID" value="CE50063"/>
        <property type="gene ID" value="WBGene00007635"/>
        <property type="gene designation" value="npr-4"/>
    </dbReference>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NeuroPeptide Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
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        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="66"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDX47441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="C16D6.2c"/>
        </source>
    </evidence>
    <sequence length="398" mass="45177" checksum="73094AB8E0BF6305" modified="2014-10-29" version="1">MLLEIGTITIGNITRARKFGERMNGSDCLNLNSELWLYREDLSSRWYIMLVFAFLYLIIIAAGIIGNSCVILAITRNKSLQTVPNLFILSLSCSDIVVCCTSATITPITAFKKEWIFGEALCRIAPFIAGISLCFSTFTLTAISIDRYILIRFPMRKPITHYQAVGVIAIICAFAATITSPIMFKQKLGEFENFCGQYCTENWGANESQRKIYGAALMFLQLVIPLTIIIISYTAISLKIGQSMILKGAKKQKTDNWEMELSDQQRIAVKRRQRTNRMLIGMVVAFACSWIWSVTFNILRDYEYLPELIKTQEYIFGIATHCIAMTSTVWNPLLYAVLNLQLRAAFIDLMPHWLRRHLNLEGDNSSPLLNHPTMTITNKPSKQHTLIPAMDNHTCQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BS39</accession>
    <name>A0A078BS39_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TSC22 domain family protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C30G4.4</name>
        <name evidence="3" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294808.1">
        <property type="nucleotide sequence ID" value="NM_001307879.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BS39"/>
    <dbReference type="SMR" id="A0A078BS39"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4h">
        <property type="protein sequence ID" value="CE50065"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BS39">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C30G4.4h"/>
        </source>
    </evidence>
    <sequence length="322" mass="35377" checksum="5B505D9A30D4BA72" modified="2014-10-29" version="1">MAALFNESLRKVNEQQPPTIIEEDETPKRANRPPDLQGFSILDEKWRSSCSDDSDDSLPVGSYISTAEKPLRFCKSVDFRPLRREAPNLTGDSCSTLPSTPVHKKNPPLPTMSSGGSRFKVVPVETRDPYFSPNGKHAIAKPTAAIKKEEIVNRSSRSLSDIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKSVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I8L7</accession>
    <name>A0A8D9I8L7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitoferrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">mfn-1</name>
        <name evidence="17" type="ORF">CELE_W02B12.9</name>
        <name evidence="19" type="ORF">W02B12.9</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAG8860243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001382726.1">
        <property type="nucleotide sequence ID" value="NM_001395808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9I8L7"/>
    <dbReference type="SMR" id="A0A8D9I8L7"/>
    <dbReference type="GeneID" id="174752"/>
    <dbReference type="AGR" id="WB:WBGene00012204"/>
    <dbReference type="CTD" id="174752"/>
    <dbReference type="WormBase" id="W02B12.9d">
        <property type="protein sequence ID" value="CE54368"/>
        <property type="gene ID" value="WBGene00012204"/>
        <property type="gene designation" value="mfn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000127">
        <property type="entry name" value="MC family mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000054">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF20">
        <property type="entry name" value="MITOFERRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="114"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="205"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG8860243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="W02B12.9d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8D9I8L7"/>
        </source>
    </evidence>
    <sequence length="318" mass="34819" checksum="D19168C43291261B" modified="2022-01-19" version="1">MGGGGEDEYESLPTHSVPIQVHLTAGALAGAVEHCVMFPFDSVKTRMQSLCPCPETKCPTPVHSLMSIVKREGWLRPLRGVNAVAAGSMPAHALYFTVYEKMKGYLTGNSAGHSNTLAYGASGVVATLIHDAIMNPAEVVKQRMQMAFSPYGSSLECARCVYNREGVAAFYRSYTTQLAMNVPFQAIHFMSYEFWQHVLNPEHKYDPKSHLIAGGLAGGLAAALTTPMDCVKTVLNTQQAAEADPANRRIFLQNELQARYRYRGISDAVRTIYSQRGLSGFSCGLQARVIFQVPATALSWSVYELFKFMLSFEGGHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4SRX3</accession>
    <name>A0A8S4SRX3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T24B8.4</name>
        <name evidence="2 4" type="ORF">T24B8.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAH2659123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4SRX3"/>
    <dbReference type="AGR" id="WB:WBGene00011978"/>
    <dbReference type="WormBase" id="T24B8.4i">
        <property type="protein sequence ID" value="CE54535"/>
        <property type="gene ID" value="WBGene00011978"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877983at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH2659123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T24B8.4i"/>
        </source>
    </evidence>
    <sequence length="152" mass="16622" checksum="A66A980C9CFC4F8F" modified="2022-10-12" version="1">MSPISSSVSSASAPSPSSLSAGSVSPDSTPKKRIVGSNANFEKHPFMSSNVPPSSLSAREQLFSSSSLPRHHRNSSNQNVINVPISAPWYSRDPIVNPEPPSVGSRRPSKQSTNPYRISFDEFTVPHPSQMRDNIRFNIDLSHDLPLSISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4SRX7</accession>
    <name>A0A8S4SRX7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ligand-Gated ion Channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">lgc-40</name>
        <name evidence="14" type="ORF">CELE_T24D8.1</name>
        <name evidence="16" type="ORF">T24D8.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAH2694482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001407535.1">
        <property type="nucleotide sequence ID" value="NM_001420568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4SRX7"/>
    <dbReference type="SMR" id="A0A8S4SRX7"/>
    <dbReference type="GeneID" id="188854"/>
    <dbReference type="AGR" id="WB:WBGene00020767"/>
    <dbReference type="CTD" id="188854"/>
    <dbReference type="WormBase" id="T24D8.1b">
        <property type="protein sequence ID" value="CE54524"/>
        <property type="gene ID" value="WBGene00020767"/>
        <property type="gene designation" value="lgc-40"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000083">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
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        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
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        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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            <begin position="23"/>
            <end position="495"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="258"/>
            <end position="276"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="304"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="316"/>
            <end position="337"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
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    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
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            <begin position="43"/>
            <end position="245"/>
        </location>
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    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
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            <begin position="257"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00023303"/>
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        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAH2694482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="T24D8.1b"/>
        </source>
    </evidence>
    <sequence length="495" mass="57193" checksum="B17C3AC385912651" modified="2022-10-12" version="1">MKLHTMIRFLLSVCCIVNVFESADLAFIPLTKAFLDKLKNETLYNRFATPTQYDEYIRVHGTGVPTNVTLSMFIEGMSSFSAQTMDYHLDVYFQEEWYDHRLAHNASAPILVRDLTVFKMMWHPDVYFANARSAAFQDITDDNFLVWVYPNGRVWYDARISIVSSCNMDLWKYPLDSQECALRILSYAYPMTVLRLLWSEKEDVPAIDRNPDITMPDMSLKHIRTGYCNGTYATGEWSCMTAIFYVEREMMHHVMQTYVPTALIVVISWFNFWLEIDSAPARVSLSITTLLTISTQANAVKLALPEVSYMKAIDVWMGSCMAFVFGVMIEFTICHYAKNLEMLRGDGQPSLIVDTALSTLFGAARDIDDLNEEEGVRGDGEQHIALNMLNPEEPRLRSLNQNNDVTANGTRYFVGAERMKRKRSKASLSRLRQQVASMRHATIDVSRRAFNWTRALRNLRGRRVAQRIDERCRIVFPMIFLLFNVAYWSFYLVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-08-21" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A6ZJ59</accession>
    <name>A6ZJ59_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">SH3 domain-containing protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">CELE_T04F8.7</name>
        <name evidence="2 4" type="ORF">T04F8.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAO78711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CE41334"/>
        <property type="gene ID" value="WBGene00011445"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_903810_0_0_1"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
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        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAO78711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T04F8.7b"/>
        </source>
    </evidence>
    <sequence length="115" mass="13439" checksum="A5EDEDA0A9B49831" modified="2007-08-21" version="1">MKKQLEAEKQDSGHHSWEKPQYAGHHVANQHSSSGSGKKRGDVRDIFRIEEQPEPEPYFRSVSARARHNYEKHRDVDVSIRAMEQVDILYMEREFALCRKSDNTIGWIPSSVFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-08-21" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>A6ZJ62</accession>
    <name>A6ZJ62_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="7">1.8.3.2</ecNumber>
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    <gene>
        <name evidence="9" type="ORF">CELE_F35G2.1</name>
        <name evidence="9 11" type="ORF">F35G2.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="7"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAO78728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A6ZJ62"/>
    <dbReference type="SMR" id="A6ZJ62"/>
    <dbReference type="PeptideAtlas" id="A6ZJ62"/>
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        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009435"/>
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        <property type="protein sequence ID" value="CE28112"/>
        <property type="gene ID" value="WBGene00009435"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020182_0_0_1"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009435">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A6ZJ62">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000005">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1960">
        <property type="entry name" value="QSOX sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042568">
        <property type="entry name" value="QSOX_FAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF20">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="280"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAO78728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F35G2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="A6ZJ62"/>
        </source>
    </evidence>
    <sequence length="433" mass="50512" checksum="0E312A4F2ECD7F54" modified="2007-08-21" version="1">MFNRYPDWPNLGHIAVDSRTTYGQLWDGVPQKANYMAILFEEYDGVGAQFVMDLISRSHILGARRALSNSPLVQMLNIRNFPTVALFRRDHQQALYMQRYTNQTVKDIDDAITNDMEQGGRRAPILTTTLAPVTTTTNTPLIDCHSHPERCRDMYYVSETDMLKAMRMALLDEVTRVPGAIRGDNFTNLHEFMTLLSNHFPVLSFQNDIRRMRAKRTTSVILRNSERARLVFTHMREFLEGRKSIGSVSSDEYRRQFESVERVYASPFPVNSTWQHCKGSSPMYRGYTCGLWTTFHALTVHTYIDTIKDDYVNPMKPLSTIQGWVKSYFGCEHCRNHFMHMTTTLFPLNERRVRHPHDMMTYLWRAHNIVNNRLHGDSTEDPQFTKMQFPAPFLCPTCHSGGQFSRRQIRNFLLRYYGSIKPHNRLADQRLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-08-21" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>A6ZJ65</accession>
    <name>A6ZJ65_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">twk-22</name>
        <name evidence="12" type="ORF">CELE_T01B4.2</name>
        <name evidence="14" type="ORF">T01B4.2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAO78724.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001375198.2"/>
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    <dbReference type="KEGG" id="cel:CELE_T01B4.2"/>
    <dbReference type="UCSC" id="T01B4.2b">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00006675"/>
    <dbReference type="CTD" id="181703"/>
    <dbReference type="WormBase" id="T01B4.2b">
        <property type="protein sequence ID" value="CE53583"/>
        <property type="gene ID" value="WBGene00006675"/>
        <property type="gene designation" value="twk-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
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    </dbReference>
    <dbReference type="Bgee" id="WBGene00006675">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TWiK family of potassium channels"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2pore_dom_K_chnl"/>
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        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF335">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
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    </dbReference>
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    </feature>
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        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAO78724.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T01B4.2b"/>
        </source>
    </evidence>
    <sequence length="725" mass="83065" checksum="1BEB71CAA5C04E37" modified="2019-11-13" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-08-21" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>A6ZJ66</accession>
    <name>A6ZJ66_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">twk-22</name>
        <name evidence="12" type="ORF">CELE_T01B4.2</name>
        <name evidence="14" type="ORF">T01B4.2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAO78725.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001361897.1">
        <property type="nucleotide sequence ID" value="NM_001375200.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A6ZJ66"/>
    <dbReference type="SMR" id="A6ZJ66"/>
    <dbReference type="GeneID" id="181703"/>
    <dbReference type="UCSC" id="T01B4.2b">
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    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006675"/>
    <dbReference type="CTD" id="181703"/>
    <dbReference type="WormBase" id="T01B4.2c">
        <property type="protein sequence ID" value="CE53558"/>
        <property type="gene ID" value="WBGene00006675"/>
        <property type="gene designation" value="twk-22"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_384149_0_0_1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="150"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAO78725.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T01B4.2c"/>
        </source>
    </evidence>
    <sequence length="704" mass="80392" checksum="7255C81C9A6D519B" modified="2019-11-13" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-08-21" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>A6ZJ67</accession>
    <name>A6ZJ67_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">prx-1</name>
        <name evidence="14" type="ORF">C11H1.4</name>
        <name evidence="12" type="ORF">CELE_C11H1.4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family. AFG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAO78730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367171.1">
        <property type="nucleotide sequence ID" value="NM_001381145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A6ZJ67"/>
    <dbReference type="SMR" id="A6ZJ67"/>
    <dbReference type="PeptideAtlas" id="A6ZJ67"/>
    <dbReference type="GeneID" id="181538"/>
    <dbReference type="KEGG" id="cel:CELE_C11H1.4"/>
    <dbReference type="UCSC" id="C11H1.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004191"/>
    <dbReference type="CTD" id="181538"/>
    <dbReference type="WormBase" id="C11H1.4b">
        <property type="protein sequence ID" value="CE05265"/>
        <property type="gene ID" value="WBGene00004191"/>
        <property type="gene designation" value="prx-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_300578_0_0_1"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004191">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A6ZJ67">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000567">
        <property type="entry name" value="ATPase, AAA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000105">
        <property type="entry name" value="PeRoXisome assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAO78730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="C11H1.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="A6ZJ67"/>
        </source>
    </evidence>
    <sequence length="270" mass="29786" checksum="B297E6F4C6826E70" modified="2007-08-21" version="1">MEDVGGMFEQKKLLEQVIIWPRKYPQLFESVGVPVSKGILLHGPSGCGKTLLANATISNSNFSVVNVKGPELLSKYIGASEENVRLVFEKARSCAPCILFFDELDSLAPKRGHDSTGVTDRVVNQLLTELDGAEGGMKGVIILGCTSRIDLIDDALLRPGRFDHHVYCGHPEKTERLDIMKVLTNKLKPTDVDFECLAQKTDGWSGADLQLLFTNAQFYNARQIAKEEDGLEEDNVPIDQASIESVFNDSIPKPKRSQVDNRIGQKVTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-08-21" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A6ZJ74</accession>
    <name>A6ZJ74_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">lron-3</name>
        <name evidence="3" type="ORF">C02C6.3</name>
        <name evidence="1" type="ORF">CELE_C02C6.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAO78700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123092.1">
        <property type="nucleotide sequence ID" value="NM_001129620.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A6ZJ74"/>
    <dbReference type="PeptideAtlas" id="A6ZJ74"/>
    <dbReference type="GeneID" id="181643"/>
    <dbReference type="KEGG" id="cel:CELE_C02C6.3"/>
    <dbReference type="UCSC" id="C02C6.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007261"/>
    <dbReference type="CTD" id="181643"/>
    <dbReference type="WormBase" id="C02C6.3c">
        <property type="protein sequence ID" value="CE41293"/>
        <property type="gene ID" value="WBGene00007261"/>
        <property type="gene designation" value="lron-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2707051_0_0_1"/>
    <dbReference type="OrthoDB" id="1574204at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007261">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A6ZJ74">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAO78700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C02C6.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="A6ZJ74"/>
        </source>
    </evidence>
    <sequence length="73" mass="8314" checksum="CAC49F65B12E3D74" modified="2007-08-21" version="1">MCGMIPSKYGLQVREKNSLVCDRASPKMYVGARIAEVPLNKLTCDEPLFTSMSSFKFNFYSMIIAFIVSKMMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-08-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A6ZJ75</accession>
    <name>A6ZJ75_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">lron-3</name>
        <name evidence="4" type="ORF">C02C6.3</name>
        <name evidence="2" type="ORF">CELE_C02C6.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAO78701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123093.1">
        <property type="nucleotide sequence ID" value="NM_001129621.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A6ZJ75"/>
    <dbReference type="PeptideAtlas" id="A6ZJ75"/>
    <dbReference type="GeneID" id="181643"/>
    <dbReference type="UCSC" id="C02C6.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007261"/>
    <dbReference type="CTD" id="181643"/>
    <dbReference type="WormBase" id="C02C6.3d">
        <property type="protein sequence ID" value="CE41294"/>
        <property type="gene ID" value="WBGene00007261"/>
        <property type="gene designation" value="lron-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_750757_0_0_1"/>
    <dbReference type="OrthoDB" id="1574204at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007261">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A6ZJ75">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAO78701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C02C6.3d"/>
        </source>
    </evidence>
    <sequence length="46" mass="5320" checksum="4D514CF8430FE819" modified="2007-08-21" version="1">MYVGARIAEVPLNKLTCDEPLFTSMSSFKFNFYSMIIAFIVSKMMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRM5</accession>
    <name>C6KRM5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">clec-199</name>
        <name evidence="9" type="ORF">C30H6.1</name>
        <name evidence="7" type="ORF">CELE_C30H6.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255946.1">
        <property type="nucleotide sequence ID" value="NM_001269017.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRM5"/>
    <dbReference type="SMR" id="C6KRM5"/>
    <dbReference type="GeneID" id="183064"/>
    <dbReference type="AGR" id="WB:WBGene00007820"/>
    <dbReference type="CTD" id="183064"/>
    <dbReference type="WormBase" id="C30H6.1a">
        <property type="protein sequence ID" value="CE43849"/>
        <property type="gene ID" value="WBGene00007820"/>
        <property type="gene designation" value="clec-199"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863877at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007820">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRM5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052309">
        <property type="entry name" value="C-type_Lectin_Domain_Fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490:SF6">
        <property type="entry name" value="ASIALOGLYCOPROTEIN RECEPTOR 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002967289" evidence="5">
        <location>
            <begin position="21"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="108"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAZ65473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C30H6.1a"/>
        </source>
    </evidence>
    <sequence length="657" mass="70770" checksum="9BEACDAC1A484127" modified="2009-09-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRM6</accession>
    <name>C6KRM6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">clec-199</name>
        <name evidence="9" type="ORF">C30H6.1</name>
        <name evidence="7" type="ORF">CELE_C30H6.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255947.1">
        <property type="nucleotide sequence ID" value="NM_001269018.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRM6"/>
    <dbReference type="SMR" id="C6KRM6"/>
    <dbReference type="GeneID" id="183064"/>
    <dbReference type="AGR" id="WB:WBGene00007820"/>
    <dbReference type="CTD" id="183064"/>
    <dbReference type="WormBase" id="C30H6.1b">
        <property type="protein sequence ID" value="CE43842"/>
        <property type="gene ID" value="WBGene00007820"/>
        <property type="gene designation" value="clec-199"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863877at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007820">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRM6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052309">
        <property type="entry name" value="C-type_Lectin_Domain_Fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490:SF6">
        <property type="entry name" value="ASIALOGLYCOPROTEIN RECEPTOR 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002965792" evidence="5">
        <location>
            <begin position="21"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="108"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAZ65474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C30H6.1b"/>
        </source>
    </evidence>
    <sequence length="643" mass="69362" checksum="598F62B1F776E676" modified="2009-09-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRN0</accession>
    <name>C6KRN0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Acetylcholine receptor subunit beta-type lev-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21 23" type="primary">lev-1</name>
        <name evidence="21" type="ORF">CELE_F09E8.7</name>
        <name evidence="23" type="ORF">F09E8.7</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255704.1">
        <property type="nucleotide sequence ID" value="NM_001268775.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRN0"/>
    <dbReference type="SMR" id="C6KRN0"/>
    <dbReference type="GeneID" id="178269"/>
    <dbReference type="AGR" id="WB:WBGene00002974"/>
    <dbReference type="CTD" id="178269"/>
    <dbReference type="WormBase" id="F09E8.7b">
        <property type="protein sequence ID" value="CE43918"/>
        <property type="gene ID" value="WBGene00002974"/>
        <property type="gene designation" value="lev-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018074_1_0_1"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002974">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRN0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015464">
        <property type="term" value="F:acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046662">
        <property type="term" value="P:regulation of egg-laying behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040012">
        <property type="term" value="P:regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd19032">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000035">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000023">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="38"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="302"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAZ65503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WormBase" id="F09E8.7b"/>
        </source>
    </evidence>
    <sequence length="482" mass="55053" checksum="F9CF12A5F3B40743" modified="2009-09-01" version="1">MMLGGGGGCGAGGTWLGFLVFLAVSLRNHSTCEDIDAEDRLMVDLFRGYNSLVQPVRNRSELPMIVKIGMQLVLLINVDEKEQVMHTNVWLTMKWDDFQLKWDPRDYANITQIRVAPEKVWLPDIVLFNNADGNYEVSFMCNVLILSTGTVLWVPPAIYKSSCIIDVEFFPFDDQLCSLTFGSWTYNRDEIKLDFLTSDRVDFSEYSTSSIWDMMDGPAVLTSDRSRIEFQIRIRRKTLFYTVVLILPTVLMAFLNVTVFYLPTASGEKMGLTMNVLLSIVVFLLLVSKILPPTSSSIPLVAKSPITHRLPPWVRKVFLDILPLLMCMQRPHRKNVIQRSHRRLLETGPSVEENPMRSGEHHPLCRHTHNQDSCRRVRIQSDELDDELSPEAQRAIDAIEFITENRRDEEITKQFRDDWKFIASVVDRFLLYGFFGATVGGTIGIIFTAPSVFETFDENATLVKLKQLYDMGLANDTVLGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-02-09" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>D1YSH6</accession>
    <name>D1YSH6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C17B7.8</name>
        <name evidence="1" type="ORF">CELE_C17B7.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD62960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256024.1">
        <property type="nucleotide sequence ID" value="NM_001269095.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D1YSH6"/>
    <dbReference type="PeptideAtlas" id="D1YSH6"/>
    <dbReference type="GeneID" id="182708"/>
    <dbReference type="AGR" id="WB:WBGene00015882"/>
    <dbReference type="CTD" id="182708"/>
    <dbReference type="WormBase" id="C17B7.8a">
        <property type="protein sequence ID" value="CE44402"/>
        <property type="gene ID" value="WBGene00015882"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035546_0_0_1"/>
    <dbReference type="OrthoDB" id="5780612at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015882">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D1YSH6">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD62960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C17B7.8a"/>
        </source>
    </evidence>
    <sequence length="432" mass="49099" checksum="9A5B92E99AADED61" modified="2010-02-09" version="1">MWYMAVKLMDTPTVGSEHFVETSREYAKKKNNSERFSFAVEKLENINLTSTNIFYNSLYANIEVLNQLNLPAAEENEFLHHIFDLMKNNTIEEIWSSALSNESKKEFEKELSKSKGFFGLLDYNNVTMLEESKLVYEAEYYRLKSLLSPDDLDTEIAEKIIRLGASDTAIKNLRIPGYQPVFLFSAFASNMANEAFNQNSNIYIGIVTRNDLQQPISTIADTFSVLAHELMHFVYPFGIRLLPSNVTKAANKCTQDEVKMMGDSDAVKPIDGWFSENITHEDLPNLLGLRMVMKMVARKSANEEQLKNALETILSGLCIQGKPKNSILPHHHPFEISINTAVRQYPLFSSLYGCRLGDRMFAEPEKFCNPLGGDVNLEDYKIKNDTEDVGGFFNYIMDTANALEQKIASAKEQKIASAFFCFISFFQQLPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-02-09" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>D1YSH9</accession>
    <name>D1YSH9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">bgnt-1.4</name>
        <name evidence="3" type="ORF">C18G1.3</name>
        <name evidence="1" type="ORF">CELE_C18G1.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD65234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256050.1">
        <property type="nucleotide sequence ID" value="NM_001269121.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D1YSH9"/>
    <dbReference type="SMR" id="D1YSH9"/>
    <dbReference type="GeneID" id="182795"/>
    <dbReference type="AGR" id="WB:WBGene00015982"/>
    <dbReference type="CTD" id="182795"/>
    <dbReference type="WormBase" id="C18G1.3a">
        <property type="protein sequence ID" value="CE44423"/>
        <property type="gene ID" value="WBGene00015982"/>
        <property type="gene designation" value="bgnt-1.4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019238_2_0_1"/>
    <dbReference type="OrthoDB" id="9974378at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015982">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D1YSH9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411">
        <property type="entry name" value="B3GNT1, BETA-1,3-N-ACETYLGUCOSAMINYLTRANSFERASE 1, HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411:SF1">
        <property type="entry name" value="B3GNT1, BETA-1,3-N-ACETYLGUCOSAMINYLTRANSFERASE 1, HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD65234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C18G1.3a"/>
        </source>
    </evidence>
    <sequence length="191" mass="22072" checksum="2F9A4C0B7182F324" modified="2010-02-09" version="1">MRNIARKGAKSDIHFIVDGDMIMSDGFAEKIKPIANQIVDGKNKNVLVVRRFETNETTIPHNHIELKNAIENKQVFQFHHRFFFAGHKISNISHWFAVSNETDEITAWEIPYSSSLWEVQVILHRNDLYNADYFPARIKVMQSLVYSLCRANYTFNLLSHVFNVHKGIKLGDTNFSKSVIAHSKRNGRNSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-05-25" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY86-2</accession>
    <name>HELQ_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform b of Helicase POLQ-like</fullName>
            <ecNumber evidence="1">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">helq-1</name>
        <name evidence="4" type="ORF">Y55B1AL.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="DNA Repair" volume="7" first="941" last="950">
            <title>Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways.</title>
            <authorList>
                <person name="Muzzini D.M."/>
                <person name="Plevani P."/>
                <person name="Boulton S.J."/>
                <person name="Cassata G."/>
                <person name="Marini F."/>
            </authorList>
            <dbReference type="PubMed" id="18472307"/>
            <dbReference type="DOI" id="10.1016/j.dnarep.2008.03.021"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="Nat. Commun." volume="12" first="7126" last="7126">
            <title>Helicase Q promotes homology-driven DNA double-strand break repair and prevents tandem duplications.</title>
            <authorList>
                <person name="Kamp J.A."/>
                <person name="Lemmens B.B.L.G."/>
                <person name="Romeijn R.J."/>
                <person name="Changoer S.C."/>
                <person name="van Schendel R."/>
                <person name="Tijsterman M."/>
            </authorList>
            <dbReference type="PubMed" id="34880204"/>
            <dbReference type="DOI" id="10.1038/s41467-021-27408-z"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KY86-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_061492"/>
        </isoform>
        <isoform>
            <id>H2KY86-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001379571.1">
        <property type="nucleotide sequence ID" value="NM_001393258.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y55B1AL.3b">
        <property type="protein sequence ID" value="CE37439"/>
        <property type="gene ID" value="WBGene00021905"/>
        <property type="gene designation" value="helq-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q8TDG4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y55B1AL.3a"/>
        </source>
    </evidence>
    <sequence length="469" mass="52366" checksum="5387D5E2A17652B5" modified="2012-03-21" version="1">MDAVLKQCILSGVAYHHSGLTQDERKCVEAAFMEGLIYVVCATSTLAAGVNLPVRRVIIKAPMVGRERLGKAQYLQMAGRAGRAGFDTKGDCITIIKAGEEERWFREMLKSDIPRCMSSLSSEESMGSFILDCVVLKLAENIEEIMTAVRYSLFYAQESPENIRKLVESSVKRLEEHYFITIEPLEQDVASEPSAQASSIPRVPGKISPSDLGNAVFNAGFDPDEATRLHADLVSSLNQGVIFASHFHLLFIITPYEQVCNINWDLFLLMYNALPSSERKLLAECGLEEKFILEAIITRVDLTAGTPRMRLYIALMLQKIWNHEPMYTVAERFGVEKGWLQATLQSSISQAASIAKFSEKITTMWPLRKLLPELVQRLSEAAQPELLPLMTVDGIKKARAAILFKAGYKTVGMIARANPLKLVQELGTIRMAQANSIIASARMVLRDQVDEKMEELDVWGVATDSFNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYU2</accession>
    <name>H2KYU2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C17E7.9</name>
        <name evidence="3" type="ORF">CELE_C17E7.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD64875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_504072.1">
        <property type="nucleotide sequence ID" value="NM_071671.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYU2"/>
    <dbReference type="PeptideAtlas" id="H2KYU2"/>
    <dbReference type="GeneID" id="178799"/>
    <dbReference type="KEGG" id="cel:CELE_C17E7.9"/>
    <dbReference type="AGR" id="WB:WBGene00015903"/>
    <dbReference type="CTD" id="178799"/>
    <dbReference type="WormBase" id="C17E7.9b">
        <property type="protein sequence ID" value="CE27701"/>
        <property type="gene ID" value="WBGene00015903"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10331343at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015903">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYU2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564281" evidence="2">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD64875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C17E7.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYU2"/>
        </source>
    </evidence>
    <sequence length="257" mass="29643" checksum="DB9CB0FD4E678AC3" modified="2012-03-21" version="1">MRWLVWLSLFLLPIATSKVTQQEAKPTFWHSDHVYGHIAEFFWCRTKKKAEEAGELLGPVRQALFEQGSALNEMLRAENRGENSQVIVEMVVLQEEEKYRDWDPIWIRKKEPYGFSRIRIFINEPSDSEVSKFCKTWPYPTTGFPTLVAISEFFYAPVLVCQFGVPTCDLGKMLLIIWIIVTFAIAFCVMTCSLWNSEILVLKKTEDSRQFGMQNLARENVHEGLADGTQVTTTVFRGPRENEGRVVLNRGCKPIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYU3</accession>
    <name>H2KYU3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2 tensin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T23B3.1</name>
        <name evidence="2 4" type="ORF">T23B3.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD64897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122521.1">
        <property type="nucleotide sequence ID" value="NM_001129049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYU3"/>
    <dbReference type="PeptideAtlas" id="H2KYU3"/>
    <dbReference type="GeneID" id="172388"/>
    <dbReference type="KEGG" id="cel:CELE_T23B3.1"/>
    <dbReference type="AGR" id="WB:WBGene00020709"/>
    <dbReference type="CTD" id="172388"/>
    <dbReference type="WormBase" id="T23B3.1b">
        <property type="protein sequence ID" value="CE41700"/>
        <property type="gene ID" value="WBGene00020709"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5787535at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020709">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYU3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD64897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T23B3.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYU3"/>
        </source>
    </evidence>
    <sequence length="388" mass="44721" checksum="700C5573CB22333B" modified="2012-03-21" version="1">MAGDLIARGISRNQNDEEYSLDMEESLFQNIVNAFLKQDGNHLRDKAAKNKSLRIFLSSQRFLTEYAKRTGRMTCLPPAEYLEKQMRDGFLPFRRHKNRFDLQEIFDKTRHGFLQIDFPIDANHGAHADEDTGDCVAPCQLRNIFILENMNIPVCRFDPLMFCQSWVLTLLRPKFVFRGMVACPKGDYGLARMIVEVGSGKRQLRSETSIAFKNGEDEKLGRFIPFEVSSPDYDFRPTYIFFFFCIFYVNRTKIEKRGMRIANCSVQCVLPPMPDDLNKIECSEGYPAEGYDSPLYNCEYTANTHNDPEYLVSLKQNFFSVLENAKGIRDADTERTERVITEMLGGNLMGDPMEIGVDNGDEKPDSAEKRSHSQMDQEDDEPAMKRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYU4</accession>
    <name>H2KYU4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_ZC239.13</name>
        <name evidence="2 4" type="ORF">ZC239.13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD64937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYU4"/>
    <dbReference type="SMR" id="H2KYU4"/>
    <dbReference type="AGR" id="WB:WBGene00022571"/>
    <dbReference type="WormBase" id="ZC239.13a">
        <property type="protein sequence ID" value="CE33490"/>
        <property type="gene ID" value="WBGene00022571"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3320505_0_0_1"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022571">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYU4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD64937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZC239.13a"/>
        </source>
    </evidence>
    <sequence length="39" mass="4197" checksum="7FF55DA87A5815B4" modified="2012-03-21" version="1">MSETVKLDVGGTIFKTSKDTLMKLDSIFKTMLESGTGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYV8</accession>
    <name>H2KYV8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C18C4.7</name>
        <name evidence="2" type="ORF">CELE_C18C4.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD65108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741539.2">
        <property type="nucleotide sequence ID" value="NM_171458.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYV8"/>
    <dbReference type="SMR" id="H2KYV8"/>
    <dbReference type="PaxDb" id="6239-C18C4.5b"/>
    <dbReference type="PeptideAtlas" id="H2KYV8"/>
    <dbReference type="GeneID" id="178941"/>
    <dbReference type="AGR" id="WB:WBGene00015968"/>
    <dbReference type="CTD" id="178941"/>
    <dbReference type="WormBase" id="C18C4.7d">
        <property type="protein sequence ID" value="CE35246"/>
        <property type="gene ID" value="WBGene00015968"/>
    </dbReference>
    <dbReference type="OMA" id="NIGQDHV"/>
    <dbReference type="OrthoDB" id="5832686at2759"/>
    <dbReference type="PhylomeDB" id="H2KYV8"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015968">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYV8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C18C4.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYV8"/>
        </source>
    </evidence>
    <sequence length="1046" mass="121493" checksum="76C0B13B69D89792" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYW2</accession>
    <name>H2KYW2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NeurABin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nab-1</name>
        <name evidence="4" type="ORF">C43E11.6</name>
        <name evidence="2" type="ORF">CELE_C43E11.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD65156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370469.1">
        <property type="nucleotide sequence ID" value="NM_001382891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYW2"/>
    <dbReference type="GeneID" id="172021"/>
    <dbReference type="AGR" id="WB:WBGene00003516"/>
    <dbReference type="CTD" id="172021"/>
    <dbReference type="WormBase" id="C43E11.6c">
        <property type="protein sequence ID" value="CE27847"/>
        <property type="gene ID" value="WBGene00003516"/>
        <property type="gene designation" value="nab-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2442842_0_0_1"/>
    <dbReference type="OrthoDB" id="62701at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003516">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYW2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036062">
        <property type="term" value="C:presynaptic periactive zone"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C43E11.6c"/>
        </source>
    </evidence>
    <sequence length="90" mass="10017" checksum="A9B5DCF357D74911" modified="2012-03-21" version="1">MTTASELLSDDARARFSHTKALFEQLERQQDVPSFYSPRLQRQPPPPLPPKPPSQCPPSPMSQVCVIKQSHGSLSLSLLLFLFSGKRNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYW3</accession>
    <name>H2KYW3_CAEEL</name>
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        <recommendedName>
            <fullName evidence="12">Neurabin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Neurabin-I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Neural tissue-specific F-actin-binding protein I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Protein phosphatase 1 regulatory subunit 9A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">nab-1</name>
        <name evidence="22" type="ORF">C43E11.6</name>
        <name evidence="20" type="ORF">CELE_C43E11.6</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD65157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367538.1">
        <property type="nucleotide sequence ID" value="NM_001379754.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYW3"/>
    <dbReference type="SMR" id="H2KYW3"/>
    <dbReference type="GeneID" id="172021"/>
    <dbReference type="AGR" id="WB:WBGene00003516"/>
    <dbReference type="CTD" id="172021"/>
    <dbReference type="WormBase" id="C43E11.6d">
        <property type="protein sequence ID" value="CE29717"/>
        <property type="gene ID" value="WBGene00003516"/>
        <property type="gene designation" value="nab-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62701at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003516">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYW3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036062">
        <property type="term" value="C:presynaptic periactive zone"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06790">
        <property type="entry name" value="PDZ_neurabin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09512">
        <property type="entry name" value="SAM_Neurabin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000010">
        <property type="entry name" value="Neurabin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000008">
        <property type="entry name" value="Neurabin-1 isoform 1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040645">
        <property type="entry name" value="Neurabin-1/2_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043446">
        <property type="entry name" value="Neurabin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16154">
        <property type="entry name" value="NEURABIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16154:SF6">
        <property type="entry name" value="SPINOPHILIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17817">
        <property type="entry name" value="PDZ_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="199"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="18">
        <location>
            <begin position="572"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="381"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCD65157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="C43E11.6d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYW3"/>
        </source>
    </evidence>
    <sequence length="658" mass="74794" checksum="9CA8D25DD39704C4" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYX0</accession>
    <name>H2KYX0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CELE_F39G3.5</name>
        <name evidence="13 15" type="ORF">F39G3.5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD65245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023901.1">
        <property type="nucleotide sequence ID" value="NM_001028730.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYX0"/>
    <dbReference type="SMR" id="H2KYX0"/>
    <dbReference type="PeptideAtlas" id="H2KYX0"/>
    <dbReference type="GeneID" id="178863"/>
    <dbReference type="AGR" id="WB:WBGene00018210"/>
    <dbReference type="CTD" id="178863"/>
    <dbReference type="WormBase" id="F39G3.5b">
        <property type="protein sequence ID" value="CE36933"/>
        <property type="gene ID" value="WBGene00018210"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069712_3_2_1"/>
    <dbReference type="OrthoDB" id="907479at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018210">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYX0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08554">
        <property type="entry name" value="Cyt_b561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF50">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD65245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F39G3.5b"/>
        </source>
    </evidence>
    <sequence length="152" mass="16999" checksum="9FF9D54E9A93AD28" modified="2012-03-21" version="1">MSSDSRLGNARSFNRFDIILSITHFVGFITICLNGYFLNTFKNGLAWPSKVKNGDNKALGKRGDQLHAFLMILAFIYFQGEALLAYRLYRYDAKIISKLLHTALHIIAIGLGITALTVIIMSTNNAGWNNFTSVHSWIGICLLSVYLVQINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYX2</accession>
    <name>H2KYX2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">nfm-1</name>
        <name evidence="9" type="ORF">CELE_F42A10.2</name>
        <name evidence="11" type="ORF">F42A10.2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD65309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_498335.1">
        <property type="nucleotide sequence ID" value="NM_065934.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYX2"/>
    <dbReference type="SMR" id="H2KYX2"/>
    <dbReference type="IntAct" id="H2KYX2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="H2KYX2"/>
    <dbReference type="GeneID" id="175870"/>
    <dbReference type="AGR" id="WB:WBGene00003593"/>
    <dbReference type="CTD" id="175870"/>
    <dbReference type="WormBase" id="F42A10.2a">
        <property type="protein sequence ID" value="CE01293"/>
        <property type="gene ID" value="WBGene00003593"/>
        <property type="gene designation" value="nfm-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003593">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYX2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17097">
        <property type="entry name" value="FERM_F1_ERM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="8">
        <location>
            <begin position="14"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="464"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="310"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD65309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F42A10.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYX2"/>
        </source>
    </evidence>
    <sequence length="654" mass="75614" checksum="23AB657D856BD137" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYX5</accession>
    <name>H2KYX5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactamase_B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C23H3.9</name>
        <name evidence="3" type="ORF">CELE_C23H3.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD65327.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_493653.4">
        <property type="nucleotide sequence ID" value="NM_061252.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYX5"/>
    <dbReference type="GeneID" id="173391"/>
    <dbReference type="AGR" id="WB:WBGene00016022"/>
    <dbReference type="CTD" id="173391"/>
    <dbReference type="WormBase" id="C23H3.9a">
        <property type="protein sequence ID" value="CE08326"/>
        <property type="gene ID" value="WBGene00016022"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016022">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYX5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200:SF49">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005682874" evidence="2">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD65327.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C23H3.9a"/>
        </source>
    </evidence>
    <sequence length="339" mass="36835" checksum="AEDB1209F94EEE5E" modified="2015-11-11" version="2">MKLFFIATVLLISGTHGATTEQLRQWILNNRESLNGQNDLAGSILRLFGWGSDKTTEATTTETTPEAPTTSEPRSHSRDVCPFFAEPLILANDFAFCRPASLGDCPVGYLCDQSVKLGRSICCKDTRRGIVPNGRPARPTQRLPLTWSTVTPTAAPSQPIPTATSRKAPWYIKDRTAWPTYNRISAEKALQKTSTTQETTTSTTAQPTTTTTATTTTTTTPLPTTTTTQPTTTTTEPTTTTTTTEPTTTTPKVNSWAKLWTSTAEPKSYVNVTVLQAGSVRPLRDGQVEAVGAITLVNDNGYIVLIDTGASSDTERLLHMKAFACVKNTLQSFIFQAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ61</accession>
    <name>H2KZ61_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">lact-5</name>
        <name evidence="4" type="ORF">C33F10.7</name>
        <name evidence="2" type="ORF">CELE_C33F10.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
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    </dbReference>
    <dbReference type="RefSeq" id="NP_001022016.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ61"/>
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    <dbReference type="MEROPS" id="S12.A10"/>
    <dbReference type="PeptideAtlas" id="H2KZ61"/>
    <dbReference type="GeneID" id="183166"/>
    <dbReference type="AGR" id="WB:WBGene00016355"/>
    <dbReference type="CTD" id="183166"/>
    <dbReference type="WormBase" id="C33F10.7b">
        <property type="protein sequence ID" value="CE37751"/>
        <property type="gene ID" value="WBGene00016355"/>
        <property type="gene designation" value="lact-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016355">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="25"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD66512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C33F10.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ61"/>
        </source>
    </evidence>
    <sequence length="336" mass="38403" checksum="3BFD76DC7748E6C8" modified="2012-03-21" version="1">MKQKLEIPIHGSVTDNIFSEVRDSFRRNFTEGWEKAGAAFCVIHKGKVIVDLWGGYADKECFKEWKEDTISTIFSCTKSVTAICFAILVDRGLLKYSDKVTKYWPEFGQNGKQDITIEMVLSHTAGLPYFPGVKFTEEDLTDNNKLSHMIENLKPVFAPGTRTAYHALTFGWLTDQIFRRVDSQKRTVGQFFKDEIATKHYIDIHIGECSNEENRLARLFKCPATLVSREIAYDRSILKLARYYYNPRGLFAAARRNLSLHGSDFTMFNNSDLRVVGQPAVNGIGSARAMAQLHQLVLDGTLLSKETFDVRYFMEKRMSCLVLDQLHESCQSLKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ63</accession>
    <name>H2KZ63_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Neuropeptide-Like Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nssp-16</name>
        <name evidence="2" type="ORF">CELE_T23B7.3</name>
        <name evidence="4" type="ORF">T23B7.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCE67236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254093.1">
        <property type="nucleotide sequence ID" value="NM_001267164.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ63"/>
    <dbReference type="GeneID" id="4363018"/>
    <dbReference type="AGR" id="WB:WBGene00044767"/>
    <dbReference type="CTD" id="4363018"/>
    <dbReference type="WormBase" id="T23B7.3b">
        <property type="protein sequence ID" value="CE46718"/>
        <property type="gene ID" value="WBGene00044767"/>
        <property type="gene designation" value="nssp-16"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5815175at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044767">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ63">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564295" evidence="1">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCE67236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T23B7.3b"/>
        </source>
    </evidence>
    <sequence length="111" mass="13323" checksum="4021E60BEF112CA5" modified="2012-03-21" version="1">MSNTYNHFVFRFLFIVLLLTQFIASSPMMVVRRVPTPYYQTIQKLERMIDNEQVLRRYRKSIPDGYFDEFSVLTDVLDRQRRGQPISDYTDEFSADPFEFPLRSIKQKGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ64</accession>
    <name>H2KZ64_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F20A1.6</name>
        <name evidence="3 5" type="ORF">F20A1.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD66542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023820.1">
        <property type="nucleotide sequence ID" value="NM_001028649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ64"/>
    <dbReference type="GeneID" id="179087"/>
    <dbReference type="AGR" id="WB:WBGene00017618"/>
    <dbReference type="CTD" id="179087"/>
    <dbReference type="WormBase" id="F20A1.6b">
        <property type="protein sequence ID" value="CE37002"/>
        <property type="gene ID" value="WBGene00017618"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095083_0_0_1"/>
    <dbReference type="OrthoDB" id="5850572at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017618">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ64">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003563884" evidence="2">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD66542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F20A1.6b"/>
        </source>
    </evidence>
    <sequence length="181" mass="20519" checksum="BBAD26C6D52D4D75" modified="2012-03-21" version="1">MDNNRKIIVLALMMVGMAAAVEIQNSGSFATGTDYQKEKERQGQDPNNYKKTYHKEIPGGSEHAEVVASNEPGSNSWSQTYSKHQSFGSSDTQQSQMMYQPDGFDDWMRDHVRIMNEMMRMQNAQIQALQQLISSSSYPRRTASYSAVKPTEIHYHTPKTVDGEVVVPRSLRDSGKRHNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ65</accession>
    <name>H2KZ65_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">twk-11</name>
        <name evidence="12" type="ORF">CELE_F20A1.7</name>
        <name evidence="14" type="ORF">F20A1.7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD66543.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343632.1">
        <property type="nucleotide sequence ID" value="NM_001356689.2"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="H2KZ65"/>
    <dbReference type="GeneID" id="179088"/>
    <dbReference type="KEGG" id="cel:CELE_F20A1.7"/>
    <dbReference type="AGR" id="WB:WBGene00006666"/>
    <dbReference type="CTD" id="179088"/>
    <dbReference type="WormBase" id="F20A1.7a">
        <property type="protein sequence ID" value="CE52090"/>
        <property type="gene ID" value="WBGene00006666"/>
        <property type="gene designation" value="twk-11"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001564_0_0_1"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006666">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ65">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF61">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="159"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="308"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="297"/>
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    <sequence length="1492" mass="166752" checksum="8EF5786CBC169421" modified="2017-12-20" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ67</accession>
    <name>H2KZ67_CAEEL</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">Bristol N2</strain>
        </source>
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        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="96"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD66554.2"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
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    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ67"/>
        </source>
    </evidence>
    <sequence length="1167" mass="132450" checksum="C69C7EA61DA334C5" modified="2013-02-06" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ68</accession>
    <name>H2KZ68_CAEEL</name>
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        <submittedName>
            <fullName evidence="12">CRE-MEC-1 protein</fullName>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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    <dbReference type="CTD" id="188259"/>
    <dbReference type="WormBase" id="T07H8.4e">
        <property type="protein sequence ID" value="CE37672"/>
        <property type="gene ID" value="WBGene00003165"/>
        <property type="gene designation" value="mec-1"/>
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    <dbReference type="OrthoDB" id="4473401at2759"/>
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    <dbReference type="Bgee" id="WBGene00003165">
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD66556.1"/>
        </source>
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        <source>
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        <source>
            <dbReference type="WormBase" id="T07H8.4e"/>
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        <source>
            <dbReference type="PeptideAtlas" id="H2KZ68"/>
        </source>
    </evidence>
    <sequence length="1954" mass="222691" checksum="573516F164D45F10" modified="2012-03-21" version="1"> </sequence>
</entry>
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    <accession>H2KZ71</accession>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <location>
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            <begin position="48"/>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD66636.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="ZC477.3c"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="H2KZ71"/>
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</entry>
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    <organism evidence="7 8">
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="WBGene00016422"/>
        <property type="gene designation" value="noah-1"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
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    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="WormBase"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD66994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379791.1">
        <property type="nucleotide sequence ID" value="NM_001392507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ87"/>
    <dbReference type="GeneID" id="178878"/>
    <dbReference type="AGR" id="WB:WBGene00016511"/>
    <dbReference type="CTD" id="178878"/>
    <dbReference type="WormBase" id="C37H5.13b">
        <property type="protein sequence ID" value="CE27835"/>
        <property type="gene ID" value="WBGene00016511"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158182_0_0_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016511">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ87">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD66994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C37H5.13b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ87"/>
        </source>
    </evidence>
    <sequence length="132" mass="15025" checksum="0BFADA381DFB50ED" modified="2012-03-21" version="1">MLVGCRTARHFVKSTARRFIEQKRLESLTTGNGMSSPSSTHANTAPVVQSHFAHRPQHVSSAPSRSMEIDDQNGVQHYPMLLNVTHIDMTSRADDIRAGLIDTFLNLERVDKNLYLTYFPPTIEEFFYGWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ88</accession>
    <name>H2KZ88_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">ugt-9</name>
        <name evidence="13" type="ORF">CELE_T19H12.1</name>
        <name evidence="15" type="ORF">T19H12.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD67007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123019.1">
        <property type="nucleotide sequence ID" value="NM_001129547.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ88"/>
    <dbReference type="SMR" id="H2KZ88"/>
    <dbReference type="PeptideAtlas" id="H2KZ88"/>
    <dbReference type="GeneID" id="178883"/>
    <dbReference type="KEGG" id="cel:CELE_T19H12.1"/>
    <dbReference type="AGR" id="WB:WBGene00020587"/>
    <dbReference type="CTD" id="178883"/>
    <dbReference type="WormBase" id="T19H12.1b">
        <property type="protein sequence ID" value="CE41265"/>
        <property type="gene ID" value="WBGene00020587"/>
        <property type="gene designation" value="ugt-9"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020587">
        <property type="expression patterns" value="Expressed in material anatomical entity and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ88">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000228">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF95">
        <property type="entry name" value="GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003563290" description="glucuronosyltransferase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD67007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="T19H12.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ88"/>
        </source>
    </evidence>
    <sequence length="532" mass="60628" checksum="8C1E22501A78AC5E" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ89</accession>
    <name>H2KZ89_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CELE_R02F11.3</name>
        <name evidence="12 14" type="ORF">R02F11.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD67011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024065.1">
        <property type="nucleotide sequence ID" value="NM_001028894.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ89"/>
    <dbReference type="SMR" id="H2KZ89"/>
    <dbReference type="PeptideAtlas" id="H2KZ89"/>
    <dbReference type="GeneID" id="178869"/>
    <dbReference type="KEGG" id="cel:CELE_R02F11.3"/>
    <dbReference type="AGR" id="WB:WBGene00019841"/>
    <dbReference type="CTD" id="178869"/>
    <dbReference type="WormBase" id="R02F11.3a">
        <property type="protein sequence ID" value="CE36883"/>
        <property type="gene ID" value="WBGene00019841"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_2_1_1"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019841">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ89">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000034">
        <property type="entry name" value="Protein CBG00606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF13">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="176"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="378"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD67011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="R02F11.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ89"/>
        </source>
    </evidence>
    <sequence length="467" mass="52363" checksum="69EA92B1A3085A58" modified="2012-03-21" version="1">MTKTEATFSLLDEEEERDEVGPSTVLVPGRPSLRSISLSQAPSAPRDLENGNGQTSCAELHKLTAGSTTSLSSQSKNAKKVNKFYKKQNELLENFKNDSEQIEQFNRTRRRTTSKEEDDDADVIAAIPPPIPEEKAVVAPLVKHIKPMERTDTEEKSVDEKKDDESNTAARMANITLAVNFLLMIAKVVASVLSGSMSIISSMVDSVVDITSGLVISLSERMIKKRDPYLYPRGRTRLEPLSLILISVIMGMASIQLIIASVRGIHDGIQFHLYGIGEEPKLNVTITSVVIMVSTVLVKLSLYLFCKRYKEPSVNVLAMDHRNDCISNTVALICAWLGTKYSYYFDPAGAIVVSMYILYTWVQTGREHLAKLSGKTAEPEFINRIIKVCLDHDARISHIDTVYVYHFGSKFLVEVHIVLDENMILKESHDISETLQSNIESLPEVERAFVHTDYDYDHHPHDEHKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ91</accession>
    <name>H2KZ91_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAP30_Sin3_bdg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C38C5.1</name>
        <name evidence="2" type="ORF">CELE_C38C5.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67041.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257025.2">
        <property type="nucleotide sequence ID" value="NM_001270096.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ91"/>
    <dbReference type="SMR" id="H2KZ91"/>
    <dbReference type="GeneID" id="183305"/>
    <dbReference type="KEGG" id="cel:CELE_C38C5.1"/>
    <dbReference type="AGR" id="WB:WBGene00016518"/>
    <dbReference type="CTD" id="183305"/>
    <dbReference type="WormBase" id="C38C5.1a">
        <property type="protein sequence ID" value="CE53326"/>
        <property type="gene ID" value="WBGene00016518"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2833506_0_0_1"/>
    <dbReference type="OrthoDB" id="5868946at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016518">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ91">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD67041.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C38C5.1a"/>
        </source>
    </evidence>
    <sequence length="137" mass="14772" checksum="BDC7CE66D454362E" modified="2019-07-31" version="2">MTSPPSSPSHLHVRKLSTTNEDEAKTTSGGPRKPGRKLVALSGEEDIMSGGPPPVQQPKRFRNGHASFRLRMLQEQHGPAGGTPTTGSGSGFEPVFMTKKRTRDNKSVMSEFKGGDLNKYTAKTYAIQNGNEVFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ92</accession>
    <name>H2KZ92_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mec-2</name>
        <name evidence="6" type="ORF">CELE_F14D12.4</name>
        <name evidence="8" type="ORF">F14D12.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD83470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024567.1">
        <property type="nucleotide sequence ID" value="NM_001029396.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ92"/>
    <dbReference type="SMR" id="H2KZ92"/>
    <dbReference type="PeptideAtlas" id="H2KZ92"/>
    <dbReference type="GeneID" id="180826"/>
    <dbReference type="AGR" id="WB:WBGene00003166"/>
    <dbReference type="CTD" id="180826"/>
    <dbReference type="WormBase" id="F14D12.4c">
        <property type="protein sequence ID" value="CE37633"/>
        <property type="gene ID" value="WBGene00003166"/>
        <property type="gene designation" value="mec-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_0_1"/>
    <dbReference type="OMA" id="THPYQGL"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003166">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ92">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007638">
        <property type="term" value="P:mechanosensory behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009612">
        <property type="term" value="P:response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd03403">
        <property type="entry name" value="SPFH_stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="64"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD83470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F14D12.4c"/>
        </source>
    </evidence>
    <sequence length="317" mass="34872" checksum="D0454B065F71CC56" modified="2012-03-21" version="1">MKPRETVATTSGTDSTPKTTILPAKKDYFHVEANIQNEFGVCGWILTILSYLLIFFTLPISACMCIKVVQEYERAVIFRLGRLMPGGAKGPGIFFIVPCIDTYRKVDLRVLSFEVPPQEILSKDSVTVAVDAVVYFRISNATISVTNVEDAARSTKLLAQTTLRNILGTKTLAEMLSDREAISHQMQTTLDEATEPWGVKVERVEVKDVRLPVQLQRAMAAEAEAAREARAKVIVAEGEQKASRALKEAAEVIAESPSALQLRYLQTLNSISAEKNSTIIFPFPIDLLSAFLQRTPPKVDNNFAFPTHKAGGIPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ94</accession>
    <name>H2KZ94_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">lgx-1</name>
        <name evidence="6" type="ORF">C54G7.3</name>
        <name evidence="4" type="ORF">CELE_C54G7.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67046.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359928.1">
        <property type="nucleotide sequence ID" value="NM_001373298.3"/>
    </dbReference>
    <dbReference type="SMR" id="H2KZ94"/>
    <dbReference type="PeptideAtlas" id="H2KZ94"/>
    <dbReference type="GeneID" id="180825"/>
    <dbReference type="KEGG" id="cel:CELE_C54G7.3"/>
    <dbReference type="AGR" id="WB:WBGene00002983"/>
    <dbReference type="CTD" id="180825"/>
    <dbReference type="WormBase" id="C54G7.3a">
        <property type="protein sequence ID" value="CE53211"/>
        <property type="gene ID" value="WBGene00002983"/>
        <property type="gene designation" value="lgx-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_235868_0_0_1"/>
    <dbReference type="PhylomeDB" id="H2KZ94"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002983">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ94">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10974">
        <property type="entry name" value="CE4_CDA_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF11">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020977453" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="535"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="626"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="736"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="787"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="852"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="899"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD67046.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C54G7.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ94"/>
        </source>
    </evidence>
    <sequence length="1554" mass="168959" checksum="92C478B455E9C340" modified="2019-07-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ95</accession>
    <name>H2KZ95_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y48G9A.9</name>
        <name evidence="4 6" type="ORF">Y48G9A.9</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD67071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022892.1">
        <property type="nucleotide sequence ID" value="NM_001027721.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ95"/>
    <dbReference type="SMR" id="H2KZ95"/>
    <dbReference type="PeptideAtlas" id="H2KZ95"/>
    <dbReference type="GeneID" id="175343"/>
    <dbReference type="KEGG" id="cel:CELE_Y48G9A.9"/>
    <dbReference type="AGR" id="WB:WBGene00021702"/>
    <dbReference type="CTD" id="175343"/>
    <dbReference type="WormBase" id="Y48G9A.9a">
        <property type="protein sequence ID" value="CE27280"/>
        <property type="gene ID" value="WBGene00021702"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001645_9_4_1"/>
    <dbReference type="OMA" id="KRAQCIQ"/>
    <dbReference type="OrthoDB" id="8815311at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021702">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ95">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000114">
        <property type="entry name" value="Tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="261"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD67071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y48G9A.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ95"/>
        </source>
    </evidence>
    <sequence length="352" mass="40434" checksum="8A3D9D0B0EC15958" modified="2012-03-21" version="1">MLKIFGDKKGKEKKGKNNNNVNEKRPASAQSSNGTETDDHHRKYVETLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESSDEFEICNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVSEKALAAADAFLKSYDEHLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>H7BRM4</accession>
    <name>H7BRM4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 25" type="primary">slo-1</name>
        <name evidence="23" type="ORF">CELE_Y51A2D.19</name>
        <name evidence="25" type="ORF">Y51A2D.19</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="journal article" date="2011" name="Genetics" volume="0" first="0" last="0">
            <title>Cell Excitability Necessary for Male Mating Behavior in Caenorhabditis elegans is Coordinated by Interactions Between BK and EAG Family K+ Channels.</title>
            <authorList>
                <person name="LeBoeuf B."/>
                <person name="Garcia L.R."/>
            </authorList>
            <dbReference type="PubMed" id="22174070"/>
            <dbReference type="DOI" id="10.1534/genetics.111.137455"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2012-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="LeBoeuf B."/>
                <person name="Garcia L.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JQ606809">
        <property type="protein sequence ID" value="AFA28176.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256804.1">
        <property type="nucleotide sequence ID" value="NM_001269875.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H7BRM4"/>
    <dbReference type="SMR" id="H7BRM4"/>
    <dbReference type="GeneID" id="180203"/>
    <dbReference type="AGR" id="WB:WBGene00004830"/>
    <dbReference type="CTD" id="180203"/>
    <dbReference type="WormBase" id="Y51A2D.19e">
        <property type="protein sequence ID" value="CE47346"/>
        <property type="gene ID" value="WBGene00004830"/>
        <property type="gene designation" value="slo-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004830">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H7BRM4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000035">
        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="371"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="812"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AFA28176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCG28227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WormBase" id="Y51A2D.19e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="26">
        <source>
            <dbReference type="PeptideAtlas" id="H7BRM4"/>
        </source>
    </evidence>
    <sequence length="1153" mass="131129" checksum="067827C74B504227" modified="2012-04-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>H7BRM5</accession>
    <name>H7BRM5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 25" type="primary">slo-1</name>
        <name evidence="23" type="ORF">CELE_Y51A2D.19</name>
        <name evidence="25" type="ORF">Y51A2D.19</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="journal article" date="2011" name="Genetics" volume="0" first="0" last="0">
            <title>Cell Excitability Necessary for Male Mating Behavior in Caenorhabditis elegans is Coordinated by Interactions Between BK and EAG Family K+ Channels.</title>
            <authorList>
                <person name="LeBoeuf B."/>
                <person name="Garcia L.R."/>
            </authorList>
            <dbReference type="PubMed" id="22174070"/>
            <dbReference type="DOI" id="10.1534/genetics.111.137455"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2012-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="LeBoeuf B."/>
                <person name="Garcia L.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JQ606810">
        <property type="protein sequence ID" value="AFA28177.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256806.1">
        <property type="nucleotide sequence ID" value="NM_001269877.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H7BRM5"/>
    <dbReference type="SMR" id="H7BRM5"/>
    <dbReference type="GeneID" id="180203"/>
    <dbReference type="AGR" id="WB:WBGene00004830"/>
    <dbReference type="CTD" id="180203"/>
    <dbReference type="WormBase" id="Y51A2D.19h">
        <property type="protein sequence ID" value="CE47467"/>
        <property type="gene ID" value="WBGene00004830"/>
        <property type="gene designation" value="slo-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006846_0_0_1"/>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004830">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H7BRM5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000035">
        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="371"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="777"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AFA28177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CCG28226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WormBase" id="Y51A2D.19h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="26">
        <source>
            <dbReference type="PeptideAtlas" id="H7BRM5"/>
        </source>
    </evidence>
    <sequence length="1118" mass="127037" checksum="94B2399024E6117F" modified="2012-04-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>H7BRM7</accession>
    <name>H7BRM7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23 25" type="primary">slo-1</name>
        <name evidence="23" type="ORF">CELE_Y51A2D.19</name>
        <name evidence="25" type="ORF">Y51A2D.19</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="journal article" date="2011" name="Genetics" volume="0" first="0" last="0">
            <title>Cell Excitability Necessary for Male Mating Behavior in Caenorhabditis elegans is Coordinated by Interactions Between BK and EAG Family K+ Channels.</title>
            <authorList>
                <person name="LeBoeuf B."/>
                <person name="Garcia L.R."/>
            </authorList>
            <dbReference type="PubMed" id="22174070"/>
            <dbReference type="DOI" id="10.1534/genetics.111.137455"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2012-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="LeBoeuf B."/>
                <person name="Garcia L.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JQ606812">
        <property type="protein sequence ID" value="AFA28179.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256810.1">
        <property type="nucleotide sequence ID" value="NM_001269881.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H7BRM7"/>
    <dbReference type="SMR" id="H7BRM7"/>
    <dbReference type="GeneID" id="180203"/>
    <dbReference type="AGR" id="WB:WBGene00004830"/>
    <dbReference type="CTD" id="180203"/>
    <dbReference type="WormBase" id="Y51A2D.19l">
        <property type="protein sequence ID" value="CE47226"/>
        <property type="gene ID" value="WBGene00004830"/>
        <property type="gene designation" value="slo-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004830">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H7BRM7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000035">
        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="371"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="790"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCG28228.1"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="CCJ09399.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="W02A2.8c"/>
        </source>
    </evidence>
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</entry>
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        <submittedName>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <feature type="domain" description="EGF-like" evidence="9">
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    <feature type="domain" description="EGF-like" evidence="9">
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCJ09404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="ZK783.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="I7K4J2"/>
        </source>
    </evidence>
    <sequence length="2734" mass="287216" checksum="3A51BF8E20BE08FE" modified="2012-10-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>I7K4P7</accession>
    <name>I7K4P7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C18D4.4</name>
        <name evidence="2" type="ORF">CELE_C18D4.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCJ09635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263915.1">
        <property type="nucleotide sequence ID" value="NM_001276986.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I7K4P7"/>
    <dbReference type="GeneID" id="182784"/>
    <dbReference type="AGR" id="WB:WBGene00007674"/>
    <dbReference type="CTD" id="182784"/>
    <dbReference type="WormBase" id="C18D4.4c">
        <property type="protein sequence ID" value="CE47733"/>
        <property type="gene ID" value="WBGene00007674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007674">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="I7K4P7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.20">
        <property type="entry name" value="Vitelline membrane outer layer protein I (VOMI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005515">
        <property type="entry name" value="VOMI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036706">
        <property type="entry name" value="VOMI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841:SF0">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER 1 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER PROTEIN I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03762">
        <property type="entry name" value="VOMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51092">
        <property type="entry name" value="Vitelline membrane outer protein-I (VMO-I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003711647" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCJ09635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C18D4.4c"/>
        </source>
    </evidence>
    <sequence length="82" mass="9226" checksum="E6B446FF20C29B85" modified="2012-10-03" version="1">MTMNTSWLFLAITISVLPLIQCRHVLYLGSPRVNNQGTWKAWQICHDGWFVHGMQLKYEATGGDLTGMNAVALYCQRIGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>O16917</accession>
    <name>O16917_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucuronosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F10D2.8</name>
        <name evidence="1 3" type="ORF">F10D2.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD69122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_504813.2">
        <property type="nucleotide sequence ID" value="NM_072412.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O16917"/>
    <dbReference type="SMR" id="O16917"/>
    <dbReference type="CAZy" id="GT1">
        <property type="family name" value="Glycosyltransferase Family 1"/>
    </dbReference>
    <dbReference type="PaxDb" id="6239-F10D2.8"/>
    <dbReference type="GeneID" id="266913"/>
    <dbReference type="UCSC" id="F10D2.8">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017334"/>
    <dbReference type="CTD" id="266913"/>
    <dbReference type="WormBase" id="F10D2.8a">
        <property type="protein sequence ID" value="CE30748"/>
        <property type="gene ID" value="WBGene00017334"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2005958_0_0_1"/>
    <dbReference type="OMA" id="SEPFTIC"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="O16917"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017334">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O16917">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD69122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F10D2.8a"/>
        </source>
    </evidence>
    <sequence length="124" mass="14349" checksum="D58A1009397BCEC1" modified="2002-10-01" version="2">MRTFLVILSLIYSTYSYNFLVFCPLFGHSHTKFFATIADALTDAGHNVTFFTPTIVEKYRNVSYTKLTKDVVHMDAPKKLMEYGEQMESADFSRFWTEDSSFYNVGAADLYRCSIRLNGLFKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>O45440</accession>
    <name>O45440_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">clec-62</name>
        <name evidence="4" type="ORF">CELE_F35C5.5</name>
        <name evidence="6" type="ORF">F35C5.5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAB03054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21754">
        <property type="entry name" value="T21754"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_496742.1">
        <property type="nucleotide sequence ID" value="NM_064341.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O45440"/>
    <dbReference type="SMR" id="O45440"/>
    <dbReference type="PeptideAtlas" id="O45440"/>
    <dbReference type="GeneID" id="174926"/>
    <dbReference type="UCSC" id="F35C5.5a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009393"/>
    <dbReference type="CTD" id="174926"/>
    <dbReference type="WormBase" id="F35C5.5b">
        <property type="protein sequence ID" value="CE15946"/>
        <property type="gene ID" value="WBGene00009393"/>
        <property type="gene designation" value="clec-62"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060615_0_0_1"/>
    <dbReference type="OrthoDB" id="5787264at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009393">
        <property type="expression patterns" value="Expressed in material anatomical entity and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O45440">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000142">
        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000136">
        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024:SF15">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004159171" evidence="1">
        <location>
            <begin position="17"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="35"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="247"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB03054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F35C5.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="O45440"/>
        </source>
    </evidence>
    <sequence length="387" mass="42990" checksum="5F8865659072167B" modified="1998-06-01" version="1">MLIGLLLLFLLSVTYGQVPPTDRNCGHDLANLWLDVVVVVDNSAPMTQEGLTEVAAQIVTVFGAGTRIGTNYIDKRTTRVGLVTYNTEATIQADLNRFQSPDDLFSTVFQILPNDLSTSEDVFLAKGIGAAEQLLAAGRKNNTRKNYKQMVIVYASAYNDEGEEDPRPIAERLKASGVSIATVAFDQTGDEEMIKLIGEIATPGFNFTNEDENLVKEIQTAMIQTNCYCSNLWTQYRETFEDPHSSKFGVCLRPVALTAGWTPAKFACQNMIQTGYMVTEYDQKKHDYVFKLVRNDTSFPEPYVYHIGLSYVNGGYAWQQPVGHALVPLNDSLWNPGFPTQSSTTTAVLNQQSSSAFRVGWQNVNQYTVSERYVCEVAACDTSTYCE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="172" xmlns="https://uniprot.org/uniprot">
    <accession>P46549-2</accession>
    <name>SULU_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Serine/threonine-protein kinase SULU</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Protein kinase 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">kin-18</name>
        <name type="synonym">sulu</name>
        <name type="ORF">T17E9.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1995-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cope M.J.T.V."/>
                <person name="Kendrick-Jones A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Gene" volume="279" first="137" last="147">
            <title>kin-18, a C. elegans protein kinase involved in feeding.</title>
            <authorList>
                <person name="Berman K.S."/>
                <person name="Hutchison M."/>
                <person name="Avery L."/>
                <person name="Cobb M.H."/>
            </authorList>
            <dbReference type="PubMed" id="11733138"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Dev. Biol." volume="373" first="26" last="38">
            <title>The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo.</title>
            <authorList>
                <person name="Spiga F.M."/>
                <person name="Prouteau M."/>
                <person name="Gotta M."/>
            </authorList>
            <dbReference type="PubMed" id="23064028"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2012.10.001"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2016" name="Genetics" volume="202" first="45" last="59">
            <title>Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling.</title>
            <authorList>
                <person name="Yin Y."/>
                <person name="Donlevy S."/>
                <person name="Smolikove S."/>
            </authorList>
            <dbReference type="PubMed" id="26510792"/>
            <dbReference type="DOI" id="10.1534/genetics.115.177295"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 47-ALA--THR-642</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P46549-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020525 VSP_020524"/>
        </isoform>
        <isoform>
            <id>P46549-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="WormBase" id="T17E9.1b">
        <property type="protein sequence ID" value="CE32936"/>
        <property type="gene ID" value="WBGene00002201"/>
        <property type="gene designation" value="kin-18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q0KHQ5"/>
        </source>
    </evidence>
    <sequence length="353" mass="40010" checksum="C78FC46407DFCC8B" modified="1995-11-01" version="1">MAPAVLQKPGVIKDPSIAALFSNKDPEQRYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKWNDILKEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVEIAAICSQTLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSASLVDPAQTFIGTPFFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLFSMNAMSALYHIAQNDPPTLSPIDTSEQPEWSLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSDTIQELIQRTKNMVLELDNFQYKKMRKLMYLDETEGKEGSEGNGASDDLDFHGNENHG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q09477-2</accession>
    <name>DPFF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Zinc finger protein dpff-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dpff-1</name>
        <name evidence="2" type="ORF">C28H8.9</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="Genesis" volume="55" first="0" last="0">
            <title>DPFF-1 transcription factor deficiency causes the aberrant activation of MPK-1 and meiotic defects in the Caenorhabditis elegans germline.</title>
            <authorList>
                <person name="Villanueva-Chimal E."/>
                <person name="Salinas L.S."/>
                <person name="Fernandez-Cardenas L.P."/>
                <person name="Huelgas-Morales G."/>
                <person name="Cabrera-Wrooman A."/>
                <person name="Navarro R.E."/>
            </authorList>
            <dbReference type="PubMed" id="28940692"/>
            <dbReference type="DOI" id="10.1002/dvg.23072"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09477-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09477-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_057652 VSP_057651 VSP_057653"/>
        </isoform>
        <isoform>
            <id>Q09477-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_057652 VSP_057653"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001359900.1">
        <property type="nucleotide sequence ID" value="NM_001372602.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C28H8.9b">
        <property type="protein sequence ID" value="CE32813"/>
        <property type="gene ID" value="WBGene00016200"/>
        <property type="gene designation" value="dpff-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q92784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C28H8.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C28H8.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C28H8.9c"/>
        </source>
    </evidence>
    <sequence length="192" mass="22301" checksum="52B988DD54EEF210" modified="2002-08-02" version="2">MISENGYMDLMRNCIKWNSRQMEDRKKRLRFPYYEHQTATAQRESRFTTRNVDHMYPSNDPNTVVQFATERWKKSKSQPPSDAVEMSMFLRENPSIQVAIDHLTPQVVGPTTESVSDSSNDSTTIRPSRQTQIKEEYRDDYVLDDELSPDEFGSDEDDWSSRKRRKGNLGPVQKATSSRKKNAARNTKASRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q09477-3</accession>
    <name>DPFF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Zinc finger protein dpff-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dpff-1</name>
        <name evidence="2" type="ORF">C28H8.9</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="Genesis" volume="55" first="0" last="0">
            <title>DPFF-1 transcription factor deficiency causes the aberrant activation of MPK-1 and meiotic defects in the Caenorhabditis elegans germline.</title>
            <authorList>
                <person name="Villanueva-Chimal E."/>
                <person name="Salinas L.S."/>
                <person name="Fernandez-Cardenas L.P."/>
                <person name="Huelgas-Morales G."/>
                <person name="Cabrera-Wrooman A."/>
                <person name="Navarro R.E."/>
            </authorList>
            <dbReference type="PubMed" id="28940692"/>
            <dbReference type="DOI" id="10.1002/dvg.23072"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09477-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09477-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_057653 VSP_057652"/>
        </isoform>
        <isoform>
            <id>Q09477-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_057651 VSP_057653 VSP_057652"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001122678.1">
        <property type="nucleotide sequence ID" value="NM_001129206.5"/>
    </dbReference>
    <dbReference type="WormBase" id="C28H8.9c">
        <property type="protein sequence ID" value="CE41615"/>
        <property type="gene ID" value="WBGene00016200"/>
        <property type="gene designation" value="dpff-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q92784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C28H8.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C28H8.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C28H8.9c"/>
        </source>
    </evidence>
    <sequence length="196" mass="22774" checksum="DCA52B2E4462C44D" modified="2002-08-02" version="2">MISENGYMDLMRNCIKWNSRQMEDRKKRLRFPYYEHQTATAQRESRFTTRNVDHMYPSNDPNTVVQFATERWKKSKSQPPSDAVEMSMFLRENPSIQVAIDHLTPQVVGPTTVRFAESVSDSSNDSTTIRPSRQTQIKEEYRDDYVLDDELSPDEFGSDEDDWSSRKRRKGNLGPVQKATSSRKKNAARNTKASRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="154" xmlns="https://uniprot.org/uniprot">
    <accession>Q19084-2</accession>
    <name>OAR2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Tyramine receptor tyra-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tyra-2</name>
        <name type="ORF">F01E11.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="J. Neurochem." volume="94" first="181" last="191">
            <title>TYRA-2 (F01E11.5): a Caenorhabditis elegans tyramine receptor expressed in the MC and NSM pharyngeal neurons.</title>
            <authorList>
                <person name="Rex E."/>
                <person name="Hapiak V."/>
                <person name="Hobson R."/>
                <person name="Smith K."/>
                <person name="Xiao H."/>
                <person name="Komuniecki R."/>
            </authorList>
            <dbReference type="PubMed" id="15953361"/>
            <dbReference type="DOI" id="10.1111/j.1471-4159.2005.03180.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19084-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_018118"/>
        </isoform>
        <isoform>
            <id>Q19084-1</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q19084-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_018117"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024521.1">
        <property type="nucleotide sequence ID" value="NM_001029350.7"/>
    </dbReference>
    <dbReference type="WormBase" id="F01E11.5a">
        <property type="protein sequence ID" value="CE38313"/>
        <property type="gene ID" value="WBGene00017157"/>
        <property type="gene designation" value="tyra-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="462" mass="52457" checksum="4069373359BB7146" modified="2002-12-06" version="3">MMSSYVMSPVDETYTLFQILKGSALFLLVLWTIFANSLVFIVLYKNPRLQTVPNLLVGNLAFSDLALGLIVLPLSSVYAIAGEWVFPDALCEVFVSADILCSTASIWNLSIVGLDRYWAITSPVAYMSKRNKRTAGIMILSVWISSALISLAPLLGWKQTAQTPNLIYEKNNTVRQCTFLDLPSYTVYSATGSFFIPTLLMFFVYFKIYQAFAKHRARQIYRQKVIRKHIESTILHEISHVLPTSDEFAKEEEEEEDSESSGQVENGLGNGNDAIIEEDECEDEDSDEKRDDHTSMTTVTATVTGPTEAPYMKREAKISKSVPIEKESAIQKREAKPMRSVMAISYEKVKRHKNRKERIYRKSLQRKPKAISAAKERRGVKVLGIILGCFTVCWAPFFTMYVLVQFCKDCSPNAHIEMFITWLGYSNSAMNPIIYTVFNRDYQIALKRLFTSEKKPSSTSRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="154" xmlns="https://uniprot.org/uniprot">
    <accession>Q19084-3</accession>
    <name>OAR2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Tyramine receptor tyra-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tyra-2</name>
        <name type="ORF">F01E11.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="J. Neurochem." volume="94" first="181" last="191">
            <title>TYRA-2 (F01E11.5): a Caenorhabditis elegans tyramine receptor expressed in the MC and NSM pharyngeal neurons.</title>
            <authorList>
                <person name="Rex E."/>
                <person name="Hapiak V."/>
                <person name="Hobson R."/>
                <person name="Smith K."/>
                <person name="Xiao H."/>
                <person name="Komuniecki R."/>
            </authorList>
            <dbReference type="PubMed" id="15953361"/>
            <dbReference type="DOI" id="10.1111/j.1471-4159.2005.03180.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19084-1</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q19084-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_018117"/>
        </isoform>
        <isoform>
            <id>Q19084-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_018118"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024522.1">
        <property type="nucleotide sequence ID" value="NM_001029351.6"/>
    </dbReference>
    <dbReference type="WormBase" id="F01E11.5b">
        <property type="protein sequence ID" value="CE35711"/>
        <property type="gene ID" value="WBGene00017157"/>
        <property type="gene designation" value="tyra-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="342" mass="39168" checksum="A2E1511F3E7BBB4B" modified="2002-12-06" version="3">MSKRNKRTAGIMILSVWISSALISLAPLLGWKQTAQTPNLIYEKNNTVRQCTFLDLPSYTVYSATGSFFIPTLLMFFVYFKIYQAFAKHRARQIYRQKLAVSSHVIRKHIESTILHEISHVLPTSDEFAKEEEEEEDSESSGQVENGLGNGNDAIIEEDECEDEDSDEKRDDHTSMTTVTATVTGPTEAPYMKREAKISKSVPIEKESAIQKREAKPMRSVMAISYEKVKRHKNRKERIYRKSLQRKPKAISAAKERRGVKVLGIILGCFTVCWAPFFTMYVLVQFCKDCSPNAHIEMFITWLGYSNSAMNPIIYTVFNRDYQIALKRLFTSEKKPSSTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q20621</accession>
    <name>Q20621_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_F49E2.2</name>
        <name evidence="4 6" type="ORF">F49E2.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
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        </source>
    </evidence>
    <sequence length="238" mass="28069" checksum="690A45A3F49A00EE" modified="1996-11-01" version="1">MLLTTRPRFLFRQRSHSASSVSEKGASFSTPQANRKNKVNGNRRMSDSNNVAYSNGSKKVFEGDIEKWEPNVYEKELLRRTWSDEFDNLYELGSAIYCYIFDHNPNCKQLFPFISKYQGDEWKESKEFRSQALKFVQTLAQVVKNIYHMERTESFLYMVGQKHVKFADRGFKHEYWDIFQDAMEFALEHRLSIMTDLDDNQKRDAVTVWRTLALYTTVHMRNGFIDGLKGVNRFPPLV</sequence>
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    <reference evidence="6 8" key="1">
        <citation type="journal article" date="1995" name="Proc. Natl. Acad. Sci. U.S.A." volume="92" first="5022" last="5026">
            <title>Molecular cloning and characterization of a conserved nuclear serine/threonine protein kinase.</title>
            <authorList>
                <person name="Millward T.A."/>
                <person name="Cron P."/>
                <person name="Hemmings B.A."/>
            </authorList>
            <dbReference type="PubMed" id="7761441"/>
            <dbReference type="DOI" id="10.1073/pnas.92.11.5022"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 59-464 (ISOFORM B)</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="1999" name="Development" volume="126" first="3679" last="3692">
            <title>Genes required for axon pathfinding and extension in the C. elegans nerve ring.</title>
            <authorList>
                <person name="Zallen J.A."/>
                <person name="Kirch S.A."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="10409513"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="6 7" key="4">
        <citation type="journal article" date="2000" name="Mol. Biol. Cell" volume="11" first="3177" last="3190">
            <title>Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family.</title>
            <authorList>
                <person name="Zallen J.A."/>
                <person name="Peckol E.L."/>
                <person name="Tobin D.M."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="10982409"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 8-476 (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="7">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="journal article" date="2004" name="Neuron" volume="44" first="239" last="249">
            <title>Mechanosensory neurite termination and tiling depend on SAX-2 and the SAX-1 kinase.</title>
            <authorList>
                <person name="Gallegos M.E."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="15473964"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2004.09.021"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q2L6W9-2</id>
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            <sequence type="described" ref="VSP_053167"/>
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        <isoform>
            <id>Q2L6W9-1</id>
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    </comment>
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        <source>
            <dbReference type="UniProtKB" id="Q9Y2H1"/>
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    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="10982409"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="9851916"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="10982409"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAF91417.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAA84441.1"/>
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    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="R11G1.4a"/>
        </source>
    </evidence>
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    <accession>Q5H9N3-2</accession>
    <name>NFI1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform b of Nuclear factor I family protein</fullName>
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    <gene>
        <name evidence="5" type="primary">nfi-1</name>
        <name evidence="5" type="ORF">ZK1290.4</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Peloderinae</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2005" name="BMC Dev. Biol." volume="5" first="24" last="24">
            <title>nfi-I affects behavior and life-span in C. elegans but is not essential for DNA replication or survival.</title>
            <authorList>
                <person name="Lazakovitch E."/>
                <person name="Kalb J.M."/>
                <person name="Matsumoto R."/>
                <person name="Hirono K."/>
                <person name="Kohara Y."/>
                <person name="Gronostajski R.M."/>
            </authorList>
            <dbReference type="PubMed" id="16242019"/>
            <dbReference type="DOI" id="10.1186/1471-213x-5-24"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2008" name="Dev. Dyn." volume="237" first="2100" last="2107">
            <title>Lifespan extension and increased pumping rate accompany pharyngeal muscle-specific expression of nfi-1 in C. elegans.</title>
            <authorList>
                <person name="Lazakovitch E."/>
                <person name="Kalb J.M."/>
                <person name="Gronostajski R.M."/>
            </authorList>
            <dbReference type="PubMed" id="18651662"/>
            <dbReference type="DOI" id="10.1002/dvdy.21632"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2009" name="Proc. Natl. Acad. Sci. U.S.A." volume="106" first="12049" last="12054">
            <title>DNA-binding specificity and in vivo targets of Caenorhabditis elegans nuclear factor I.</title>
            <authorList>
                <person name="Whittle C.M."/>
                <person name="Lazakovitch E."/>
                <person name="Gronostajski R.M."/>
                <person name="Lieb J.D."/>
            </authorList>
            <dbReference type="PubMed" id="19584245"/>
            <dbReference type="DOI" id="10.1073/pnas.0812894106"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
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        <isoform>
            <id>Q5H9N3-2</id>
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            <sequence type="described" ref="VSP_061000"/>
        </isoform>
        <isoform>
            <id>Q5H9N3-3</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061001"/>
        </isoform>
        <isoform>
            <id>Q5H9N3-1</id>
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    </comment>
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        <property type="component" value="Chromosome II"/>
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    <proteinExistence type="evidence at transcript level"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK1290.4a"/>
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    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK1290.4b"/>
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    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK1290.4c"/>
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    </evidence>
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<entry dataset="Swiss-Prot" created="2021-04-07" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q5H9N3-3</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform a of Nuclear factor I family protein</fullName>
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    <gene>
        <name evidence="5" type="primary">nfi-1</name>
        <name evidence="5" type="ORF">ZK1290.4</name>
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    <organism>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2005" name="BMC Dev. Biol." volume="5" first="24" last="24">
            <title>nfi-I affects behavior and life-span in C. elegans but is not essential for DNA replication or survival.</title>
            <authorList>
                <person name="Lazakovitch E."/>
                <person name="Kalb J.M."/>
                <person name="Matsumoto R."/>
                <person name="Hirono K."/>
                <person name="Kohara Y."/>
                <person name="Gronostajski R.M."/>
            </authorList>
            <dbReference type="PubMed" id="16242019"/>
            <dbReference type="DOI" id="10.1186/1471-213x-5-24"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2008" name="Dev. Dyn." volume="237" first="2100" last="2107">
            <title>Lifespan extension and increased pumping rate accompany pharyngeal muscle-specific expression of nfi-1 in C. elegans.</title>
            <authorList>
                <person name="Lazakovitch E."/>
                <person name="Kalb J.M."/>
                <person name="Gronostajski R.M."/>
            </authorList>
            <dbReference type="PubMed" id="18651662"/>
            <dbReference type="DOI" id="10.1002/dvdy.21632"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2009" name="Proc. Natl. Acad. Sci. U.S.A." volume="106" first="12049" last="12054">
            <title>DNA-binding specificity and in vivo targets of Caenorhabditis elegans nuclear factor I.</title>
            <authorList>
                <person name="Whittle C.M."/>
                <person name="Lazakovitch E."/>
                <person name="Gronostajski R.M."/>
                <person name="Lieb J.D."/>
            </authorList>
            <dbReference type="PubMed" id="19584245"/>
            <dbReference type="DOI" id="10.1073/pnas.0812894106"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q5H9N3-1</id>
            <name evidence="5">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q5H9N3-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_061000"/>
        </isoform>
        <isoform>
            <id>Q5H9N3-3</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061001"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022505.1">
        <property type="nucleotide sequence ID" value="NM_001027334.3"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK1290.4a">
        <property type="protein sequence ID" value="CE37597"/>
        <property type="gene ID" value="WBGene00003592"/>
        <property type="gene designation" value="nfi-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK1290.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK1290.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK1290.4c"/>
        </source>
    </evidence>
    <sequence length="807" mass="87861" checksum="75D046D2771B562F" modified="2005-02-15" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q7K6V2</accession>
    <name>Q7K6V2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y51H4A.25</name>
        <name evidence="4 6" type="ORF">Y51H4A.25</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAE46686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023482.1">
        <property type="nucleotide sequence ID" value="NM_001028311.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7K6V2"/>
    <dbReference type="GeneID" id="190159"/>
    <dbReference type="KEGG" id="cel:CELE_Y51H4A.25"/>
    <dbReference type="UCSC" id="Y51H4A.25b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013119"/>
    <dbReference type="CTD" id="190159"/>
    <dbReference type="WormBase" id="Y51H4A.25b">
        <property type="protein sequence ID" value="CE35670"/>
        <property type="gene ID" value="WBGene00013119"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2266142_0_0_1"/>
    <dbReference type="OrthoDB" id="5859488at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013119">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7K6V2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004288144" evidence="2">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE46686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y51H4A.25b"/>
        </source>
    </evidence>
    <sequence length="103" mass="11545" checksum="8DE64CE345C2A8D2" modified="2004-07-05" version="1">MLQKTALIIGALSLIAGAFSDDCPSFFTKDDNGTCTIRQCLNGGYLDVSKQICICPSGYLGIHCEADYHHSNAERSYQKVTHLGPCYMYLENYDFSEFSNEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z2A0</accession>
    <name>Q7Z2A0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">dgk-2</name>
        <name evidence="2" type="ORF">CELE_F46H6.2</name>
        <name evidence="4" type="ORF">F46H6.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024680.1">
        <property type="nucleotide sequence ID" value="NM_001029509.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z2A0"/>
    <dbReference type="SMR" id="Q7Z2A0"/>
    <dbReference type="PeptideAtlas" id="Q7Z2A0"/>
    <dbReference type="GeneID" id="180720"/>
    <dbReference type="UCSC" id="F46H6.2c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000959"/>
    <dbReference type="CTD" id="180720"/>
    <dbReference type="WormBase" id="F46H6.2b">
        <property type="protein sequence ID" value="CE34028"/>
        <property type="gene ID" value="WBGene00000959"/>
        <property type="gene designation" value="dgk-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1798195_0_0_1"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000959">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z2A0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000039">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF118">
        <property type="entry name" value="DIACYLGLYCEROL KINASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F46H6.2b"/>
        </source>
    </evidence>
    <sequence length="144" mass="15912" checksum="05DF09F647DE3840" modified="2003-10-01" version="1">MAVIDKIEIPVDIEKWRPIMVIVNPKSGSGAGKQLLRNFRAHLHPAQVVDVLKSNIAASLRWIDEHPNVDVRILIAGGDGTICSALDQIDTLSRRIPVAVLPLGTGNDLSRLLKWGKKCDGDIDVIKVCAFPESDNYERPDFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z2A2</accession>
    <name>Q7Z2A2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NeuRonal IGCAM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rig-1</name>
        <name evidence="3" type="ORF">CELE_K09E2.4</name>
        <name evidence="5" type="ORF">K09E2.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379871.1">
        <property type="nucleotide sequence ID" value="NM_001392813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z2A2"/>
    <dbReference type="GeneID" id="181115"/>
    <dbReference type="UCSC" id="K09E2.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004369"/>
    <dbReference type="CTD" id="181115"/>
    <dbReference type="WormBase" id="K09E2.4b">
        <property type="protein sequence ID" value="CE34053"/>
        <property type="gene ID" value="WBGene00004369"/>
        <property type="gene designation" value="rig-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283743_0_0_1"/>
    <dbReference type="OrthoDB" id="5982258at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004369">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z2A2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD69325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K09E2.4b"/>
        </source>
    </evidence>
    <sequence length="300" mass="32795" checksum="7EACD150E086416E" modified="2003-10-01" version="1">MLSSVRVFIGSLEPHLTFKNIALGGIITFLALIILFVCFFVFCNLRSGDKRQKSQANGKFLDTSYRIFNEQKVHKSRMFDDNAEILEADVDECSPLKVRQVDERNSGDSDKYGFNNHDENVPNLYGNLDDIIDMEATAEVPNDPTYVSASKLTGDYGVHSTARCYSPESRTSHEMLVSYSQSAPHSNANSSSPQMNGSMQRVKAYNYPDSLLYSPAGTTSSIAETNSSGNGATRAQCDSPNNAPASDESDQGIRCGGSSRNSHISSTDGTKMMTMGTFKGSTPTSSFVSTFDRRRSENVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z2A5</accession>
    <name>Q7Z2A5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MO25 (MOuse embryo scaffolding Protein) homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">mop-25.1</name>
        <name evidence="3" type="ORF">CELE_R02E12.2</name>
        <name evidence="5" type="ORF">R02E12.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the Mo25 family.</text>
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    <dbReference type="CTD" id="180685"/>
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        <property type="protein sequence ID" value="CE04779"/>
        <property type="gene ID" value="WBGene00019827"/>
        <property type="gene designation" value="mop-25.1"/>
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    <dbReference type="HOGENOM" id="CLU_029066_0_0_1"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="348"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00011012"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD64655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="R02E12.2b"/>
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    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q7Z2A5"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z2A6</accession>
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        <submittedName>
            <fullName evidence="2">MARVEL domain-containing protein</fullName>
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        <name evidence="2 4" type="ORF">M60.4</name>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
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        <property type="entry name" value="T28850"/>
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    </dbReference>
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        <property type="gene ID" value="WBGene00019780"/>
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    <dbReference type="HOGENOM" id="CLU_1846934_0_0_1"/>
    <dbReference type="OrthoDB" id="5834577at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
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    </dbReference>
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    </dbReference>
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            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD69427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="M60.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q7Z2A6"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-2422468">
            <id>Q8MXV3</id>
        </interactant>
        <interactant intactId="EBI-318782">
            <id>Q9NAN2</id>
            <label>par-6</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-2422468">
            <id>Q8MXV3</id>
        </interactant>
        <interactant intactId="EBI-2914750">
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        </interactant>
        <organismsDiffer>false</organismsDiffer>
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    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001377918.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="WormBase" id="H06I04.1c">
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        <property type="gene ID" value="WBGene00019167"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5850475at2759"/>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
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        <location>
            <begin position="105"/>
            <end position="167"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD72249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="H06I04.1c"/>
        </source>
    </evidence>
    <sequence length="231" mass="26972" checksum="34A4F718C2399D4C" modified="2002-10-01" version="1">MSREMDILLREKLEMQRNSQELEKKYKKAKFASRELAKILENDLCGTPTTSNLKNFESDDEFFEEKSLFEKSRALSRQQIPNDLLEKTRKIDFSEAKNAKNQDLIDKLIDENENLQISLNREQKMTSSLQDDLEKSRRMVIDRDEHIEELKMKLGKAETKASQCESDLTQTSSDLAMERLRCEVLTGELHEIDGIFRNTQSTIQAYADDNDRLEDQCRQAQRTILTLNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXV4</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="3 5" type="primary">ccep-135</name>
        <name evidence="3" type="ORF">CELE_H06I04.1</name>
        <name evidence="5" type="ORF">H06I04.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="3 4" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
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    <dbReference type="RefSeq" id="NP_741104.1">
        <property type="nucleotide sequence ID" value="NM_171091.8"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXV4"/>
    <dbReference type="SMR" id="Q8MXV4"/>
    <dbReference type="GeneID" id="175416"/>
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    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019167"/>
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        <property type="protein sequence ID" value="CE31020"/>
        <property type="gene ID" value="WBGene00019167"/>
        <property type="gene designation" value="ccep-135"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577770_0_0_1"/>
    <dbReference type="OrthoDB" id="5850475at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019167">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="364"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD72248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="H06I04.1b"/>
        </source>
    </evidence>
    <sequence length="428" mass="48608" checksum="ECA13877BDE21232" modified="2002-10-01" version="1">MSKETGKMAEEPPGSSSSAKPVTSSKKPPPNDVTTTTNTTKTTNSNQQEDMYLNGNNPYYGGFYANNRYLFPSTSSQATCIGTSSEDSPPPPPPSANGSIHRKHHQNANHHQNSRHAISDTVAVAGDDLSNVPAAVVIQLEKANRTIASQTLEIERLKSYQNQNLETHLLKKQIHDLEKEVRSGRSRFLEQQELLAEMSREMDILLREKLEMQRNSQELEKKYKKAKFASRELAKILENDLCGTPTTSNLKNFESDDEFFEEKSLFEKSRALSRQQIPNDLLEKTRKIDFSEAKNAKNQDLIDKLIDENENLQISLNREQKMTSSLQDDLEKSRRMVIDRDEHIEELKMKLGKAETKASQCESDLTQTSSDLAMERLRCEVLTGELHEIDGIFRNTQSTIQAYADDNDRLEDQCRQAQRTILTLNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXV7</accession>
    <name>Q8MXV7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">glr-6</name>
        <name evidence="18" type="ORF">CELE_F41B4.4</name>
        <name evidence="20" type="ORF">F41B4.4</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370595.1">
        <property type="nucleotide sequence ID" value="NM_001383601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXV7"/>
    <dbReference type="SMR" id="Q8MXV7"/>
    <dbReference type="GeneID" id="180955"/>
    <dbReference type="KEGG" id="cel:CELE_F41B4.4"/>
    <dbReference type="UCSC" id="F41B4.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001617"/>
    <dbReference type="CTD" id="180955"/>
    <dbReference type="WormBase" id="F41B4.4b">
        <property type="protein sequence ID" value="CE30983"/>
        <property type="gene ID" value="WBGene00001617"/>
        <property type="gene designation" value="glr-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068752_0_0_1"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001617">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXV7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000167">
        <property type="entry name" value="Eye-enriched kainate receptor, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="35"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCD67908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="F41B4.4b"/>
        </source>
    </evidence>
    <sequence length="328" mass="37043" checksum="D1440398A094B7A4" modified="2002-10-01" version="1">MSLLGSPFIKIEYFIEYSIIFSVWTFSAIATVITALLVTVAAVLSPKESTAEFKIQNSVWYLVCILLRAGSGYNCQAGATRLISAVWWSFTLVLIAQYTANFAALLTVDRKSMPFNSFEELGNQTEYNFGSILGGSTMQFFKYSRIETFRRLWERMQSAEPSAFVGTNHEGVNRVLNEKYVFLMESATLDYQVTQNCNLTRVGNVVLGSNGYSIALPKGSKWREKLTRQILDLNEKGIILMLKNNWWKKSQQECQSSEPEDLQTALGAENVYGLFLLLALGSGIGVLCAVLEHTHFIFFEKNKRNGQTPKLQQMIETIHAEIRNSPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N455</accession>
    <name>Q9N455_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved plasma membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y34D9A.8</name>
        <name evidence="3 5" type="ORF">Y34D9A.8</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD68054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001076619.1">
        <property type="nucleotide sequence ID" value="NM_001083150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N455"/>
    <dbReference type="SMR" id="Q9N455"/>
    <dbReference type="GeneID" id="189589"/>
    <dbReference type="KEGG" id="cel:CELE_Y34D9A.8"/>
    <dbReference type="UCSC" id="Y34D9A.8b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021333"/>
    <dbReference type="CTD" id="189589"/>
    <dbReference type="WormBase" id="Y34D9A.8a">
        <property type="protein sequence ID" value="CE21525"/>
        <property type="gene ID" value="WBGene00021333"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6076617at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021333">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N455">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD68054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y34D9A.8a"/>
        </source>
    </evidence>
    <sequence length="128" mass="13871" checksum="D164657C9270274B" modified="2000-10-01" version="1">MADSLLSNILQQEITDFPELFDMGGGAPMAREGVAQPRQTNVQATVAAVKETTTITAESSGTVTIQYSHIFFAFVAFFVLSVAVVAVIRRRSRQKSGFRNRRGGGHGGPSILQQDSDEDDILISSMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEM9</accession>
    <name>U4PEM9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">pde-3</name>
        <name evidence="10" type="ORF">CELE_E01F3.1</name>
        <name evidence="12" type="ORF">E01F3.1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293571.1">
        <property type="nucleotide sequence ID" value="NM_001306642.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEM9"/>
    <dbReference type="SMR" id="U4PEM9"/>
    <dbReference type="GeneID" id="183981"/>
    <dbReference type="AGR" id="WB:WBGene00008443"/>
    <dbReference type="CTD" id="183981"/>
    <dbReference type="WormBase" id="E01F3.1i">
        <property type="protein sequence ID" value="CE48629"/>
        <property type="gene ID" value="WBGene00008443"/>
        <property type="gene designation" value="pde-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008443">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEM9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000018">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="281"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="356"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDH93186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="E01F3.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="U4PEM9"/>
        </source>
    </evidence>
    <sequence length="693" mass="77263" checksum="E2AE09791BDAF9C6" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEN5</accession>
    <name>U4PEN5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_F49F1.7</name>
        <name evidence="4 6" type="ORF">F49F1.7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93191.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEN5"/>
    <dbReference type="SMR" id="U4PEN5"/>
    <dbReference type="AGR" id="WB:WBGene00018647"/>
    <dbReference type="WormBase" id="F49F1.7b">
        <property type="protein sequence ID" value="CE53894"/>
        <property type="gene ID" value="WBGene00018647"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098771_1_0_1"/>
    <dbReference type="OrthoDB" id="5873766at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018647">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEN5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF100">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDH93191.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F49F1.7b"/>
        </source>
    </evidence>
    <sequence length="170" mass="18883" checksum="BB0D961434ADC385" modified="2020-04-22" version="2">MCVMMPYREQCPKSCGICDSPAPTWCMDHWPECPKYQVPCSETERIKCPRSCDACGNPSTKEASVTTTNGHLQIGTTRRLQATQTTKSTETTETTETTKAIKTTKTTETTKATKTTTPSTTVKTTTTKPKPPCTDSSPNCTTWAKNGFCTNTFYPPEKRKEYCGKMCRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEP3</accession>
    <name>U4PEP3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mdt-20</name>
        <name evidence="6" type="synonym">MED20</name>
        <name evidence="7" type="ORF">CELE_Y104H12D.1</name>
        <name evidence="9" type="ORF">Y104H12D.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368264.1">
        <property type="nucleotide sequence ID" value="NM_001380037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEP3"/>
    <dbReference type="SMR" id="U4PEP3"/>
    <dbReference type="PeptideAtlas" id="U4PEP3"/>
    <dbReference type="GeneID" id="176937"/>
    <dbReference type="AGR" id="WB:WBGene00007020"/>
    <dbReference type="CTD" id="176937"/>
    <dbReference type="WormBase" id="Y104H12D.1b">
        <property type="protein sequence ID" value="CE49065"/>
        <property type="gene ID" value="WBGene00007020"/>
        <property type="gene designation" value="mdt-20"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1385324_0_0_1"/>
    <dbReference type="OrthoDB" id="1854899at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007020">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEP3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDH93202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y104H12D.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="U4PEP3"/>
        </source>
    </evidence>
    <sequence length="83" mass="9546" checksum="0870FC01533CFD3A" modified="2013-12-11" version="1">MIRVGTATQGTTVKGVVVEIEYDPSIIVIQCKDMMIEFVKSVFNKYHETLPEIFKITEKPESYTALDTMWQYLGIATKLRKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEQ6</accession>
    <name>U4PEQ6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">tat-2</name>
        <name evidence="19" type="ORF">CELE_H06H21.10</name>
        <name evidence="21" type="ORF">H06H21.10</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294445.1">
        <property type="nucleotide sequence ID" value="NM_001307516.1"/>
    </dbReference>
    <dbReference type="SMR" id="U4PEQ6"/>
    <dbReference type="GeneID" id="177256"/>
    <dbReference type="AGR" id="WB:WBGene00019166"/>
    <dbReference type="CTD" id="177256"/>
    <dbReference type="WormBase" id="H06H21.10d">
        <property type="protein sequence ID" value="CE48683"/>
        <property type="gene ID" value="WBGene00019166"/>
        <property type="gene designation" value="tat-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_3_2_1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019166">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEQ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000107">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF190">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1021"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1067"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1099"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1144"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="916"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1184"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1280"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1284"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
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            <position position="446"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <ligand>
            <name>ATP</name>
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    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="447"/>
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        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="548"/>
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        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="589"/>
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        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="612"/>
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        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="647"/>
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        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="727"/>
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    </feature>
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        <location>
            <position position="728"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="729"/>
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        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="890"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="893"/>
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            <position position="894"/>
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            <dbReference type="ARBA" id="ARBA00008109"/>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDH93217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WormBase" id="H06H21.10d"/>
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    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PeptideAtlas" id="U4PEQ6"/>
        </source>
    </evidence>
    <sequence length="1299" mass="146634" checksum="75E979213F40E99D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEQ9</accession>
    <name>U4PEQ9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="15">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 26" type="primary">egl-4</name>
        <name evidence="24" type="ORF">CELE_F55A8.2</name>
        <name evidence="26" type="ORF">F55A8.2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="15"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294450.1">
        <property type="nucleotide sequence ID" value="NM_001307521.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEQ9"/>
    <dbReference type="SMR" id="U4PEQ9"/>
    <dbReference type="PeptideAtlas" id="U4PEQ9"/>
    <dbReference type="GeneID" id="176991"/>
    <dbReference type="AGR" id="WB:WBGene00001173"/>
    <dbReference type="CTD" id="176991"/>
    <dbReference type="WormBase" id="F55A8.2h">
        <property type="protein sequence ID" value="CE48610"/>
        <property type="gene ID" value="WBGene00001173"/>
        <property type="gene designation" value="egl-4"/>
    </dbReference>
    <dbReference type="OMA" id="CDLNEPP"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001173">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEQ9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000096">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000072">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000064">
        <property type="entry name" value="cGMP-dependent protein kinase, isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF111">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0140">cGMP</keyword>
    <keyword evidence="11 15" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 15 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="22">
        <location>
            <begin position="201"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="22">
        <location>
            <begin position="319"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="472"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="23">
        <location>
            <begin position="733"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="62"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="478"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 18">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDH93222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WormBase" id="F55A8.2h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="27">
        <source>
            <dbReference type="PeptideAtlas" id="U4PEQ9"/>
        </source>
    </evidence>
    <sequence length="783" mass="87086" checksum="6A34223FA81FBBE2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF08</accession>
    <name>U4PF08_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Complex I assembly factor TIMMDC1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translocase of inner mitochondrial membrane domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CELE_Y38F2AR.3</name>
        <name evidence="9 11" type="ORF">Y38F2AR.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PF08"/>
    <dbReference type="SMR" id="U4PF08"/>
    <dbReference type="PeptideAtlas" id="U4PF08"/>
    <dbReference type="AGR" id="WB:WBGene00021421"/>
    <dbReference type="WormBase" id="Y38F2AR.3d">
        <property type="protein sequence ID" value="CE48873"/>
        <property type="gene ID" value="WBGene00021421"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5826189at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021421">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF08">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055299">
        <property type="entry name" value="TIMMDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13002">
        <property type="entry name" value="C3ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13002:SF1">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR TIMMDC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDH93324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y38F2AR.3d"/>
        </source>
    </evidence>
    <sequence length="199" mass="21947" checksum="6E8E2BD975FD749E" modified="2013-12-11" version="1">MSFLGGFLVGGATGYAQARHAYETNNVGRKYLSPSDAVKRKIDYAIVRFAKGGFGVGFKCALISGSIVFLATHITAYRDKFASWYFPAISGATACLLHTVGGVFTFPIGLLGSMKAVGLGVTSGLTLSAVVHLYAMAIDKPVNDAYRLFKRDYEKELKSASEWDSRVSELMEREQITWRQQAVKKLKQQDHEKMAIFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF13</accession>
    <name>U4PF13_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">cec-2</name>
        <name evidence="4" type="ORF">C50A2.2</name>
        <name evidence="2" type="ORF">CELE_C50A2.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294531.1">
        <property type="nucleotide sequence ID" value="NM_001307602.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PF13"/>
    <dbReference type="GeneID" id="176934"/>
    <dbReference type="KEGG" id="cel:CELE_C50A2.2"/>
    <dbReference type="AGR" id="WB:WBGene00016796"/>
    <dbReference type="CTD" id="176934"/>
    <dbReference type="WormBase" id="C50A2.2b">
        <property type="protein sequence ID" value="CE48512"/>
        <property type="gene ID" value="WBGene00016796"/>
        <property type="gene designation" value="cec-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_601626_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016796">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF13">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C50A2.2b"/>
        </source>
    </evidence>
    <sequence length="518" mass="59807" checksum="AFF0F48415407EC9" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF18</accession>
    <name>U4PF18_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C50A2.3</name>
        <name evidence="1" type="ORF">CELE_C50A2.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368295.1">
        <property type="nucleotide sequence ID" value="NM_001380034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PF18"/>
    <dbReference type="GeneID" id="183630"/>
    <dbReference type="AGR" id="WB:WBGene00016797"/>
    <dbReference type="CTD" id="183630"/>
    <dbReference type="WormBase" id="C50A2.3c">
        <property type="protein sequence ID" value="CE48563"/>
        <property type="gene ID" value="WBGene00016797"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1410041_0_0_1"/>
    <dbReference type="OrthoDB" id="5816130at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016797">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF18">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C50A2.3c"/>
        </source>
    </evidence>
    <sequence length="65" mass="7257" checksum="515E749E60F87F62" modified="2013-12-11" version="1">MSMNRQFQNQHHLSTPTVQPLNIQYLYPPRYEATLPSSECKQAPRVEHVVVEIGGDATTNSTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF24</accession>
    <name>U4PF24_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YkgJ family cysteine cluster protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F37C4.8</name>
        <name evidence="1 3" type="ORF">F37C4.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PF24"/>
    <dbReference type="AGR" id="WB:WBGene00018148"/>
    <dbReference type="WormBase" id="F37C4.8b">
        <property type="protein sequence ID" value="CE48663"/>
        <property type="gene ID" value="WBGene00018148"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3423394_0_0_1"/>
    <dbReference type="OrthoDB" id="5849525at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018148">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF24">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F37C4.8b"/>
        </source>
    </evidence>
    <sequence length="23" mass="2814" checksum="C31368368CFB3140" modified="2013-12-11" version="1">MKIENKMTTGFRLFLSCRWHCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF27</accession>
    <name>U4PF27_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y41D4A.6</name>
        <name evidence="2 4" type="ORF">Y41D4A.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PF27"/>
    <dbReference type="SMR" id="U4PF27"/>
    <dbReference type="AGR" id="WB:WBGene00021508"/>
    <dbReference type="WormBase" id="Y41D4A.6b">
        <property type="protein sequence ID" value="CE48642"/>
        <property type="gene ID" value="WBGene00021508"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_1"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021508">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF27">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y41D4A.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PF27"/>
        </source>
    </evidence>
    <sequence length="160" mass="18103" checksum="1A364AAAF1E13592" modified="2013-12-11" version="1">MARYDSVAYGHRSSSDSSTYEMYASSRSEALNTIVRRRIFAGNYFLMKQYRQKYFERALKVRRIIHDELRQAFREVDLIVTPTASGTAPKYSELRDTLFSKEDNDDYFTQAANLAGIPSISVPVGVAEDGLPIGVQLMADKLQDRAVCDVAHILDGLIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6RTP0</accession>
    <name>W6RTP0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ML domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">lin-65</name>
        <name evidence="1" type="ORF">CELE_Y71G12B.9</name>
        <name evidence="3" type="ORF">Y71G12B.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293438.1">
        <property type="nucleotide sequence ID" value="NM_001306509.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RTP0"/>
    <dbReference type="PeptideAtlas" id="W6RTP0"/>
    <dbReference type="GeneID" id="171739"/>
    <dbReference type="KEGG" id="cel:CELE_Y71G12B.9"/>
    <dbReference type="AGR" id="WB:WBGene00022149"/>
    <dbReference type="CTD" id="171739"/>
    <dbReference type="WormBase" id="Y71G12B.9c">
        <property type="protein sequence ID" value="CE49525"/>
        <property type="gene ID" value="WBGene00022149"/>
        <property type="gene designation" value="lin-65"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022962_0_0_1"/>
    <dbReference type="OrthoDB" id="5876830at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022149">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RTP0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM63578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y71G12B.9c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="W6RTP0"/>
        </source>
    </evidence>
    <sequence length="156" mass="17613" checksum="EF7AACD6AD05DA61" modified="2014-04-16" version="1">MLCVPLVSTANTISSGDSTRLPKVPRIYENLTANPDLSVTIHSSAQDFRENYQIGGKINYEYLGGFDQYNIQVFVQVSSLKFTGMNGYPDPEDRISIDWGCSKLWPCKPKSHHKFRVRFHQAQLLPKNDRITIVAVAKDKTSGIIHISQPTFITLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W6RTP7</accession>
    <name>W6RTP7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y71G12B.30</name>
        <name evidence="3 5" type="ORF">Y71G12B.30</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293448.1">
        <property type="nucleotide sequence ID" value="NM_001306519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RTP7"/>
    <dbReference type="SMR" id="W6RTP7"/>
    <dbReference type="GeneID" id="3565302"/>
    <dbReference type="AGR" id="WB:WBGene00044347"/>
    <dbReference type="CTD" id="3565302"/>
    <dbReference type="WormBase" id="Y71G12B.30b">
        <property type="protein sequence ID" value="CE49508"/>
        <property type="gene ID" value="WBGene00044347"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_1"/>
    <dbReference type="OrthoDB" id="5774282at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044347">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RTP7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF506">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="53"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM63588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y71G12B.30b"/>
        </source>
    </evidence>
    <sequence length="253" mass="28390" checksum="8301F21A2EFCFEA8" modified="2014-04-16" version="1">MFDIYGFPHVSQKDKSSRYLFLGDYIDRGPFSIEVITLLFAYRLLHPQKMFLLRGNHESRPVNMQYGFYNECKRRYSVTLYETFQWAFYCMPLCAIVGGRIMCMHGGIPFGLLSLEQIDEFQRPTDIADVGIPSDLCWADPVSGVVGFQDSPRGAGHVFGEATVKEFNEKFKLDLIVRAHQVVMDGYEFFADKKLVTIFSAPCYCGHFDNLGAVLQVATNMECTINTFGHDLSAAPIKKAPAPAQVAAAPVTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>X5M5N0-20</accession>
    <name>WNK_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform t of Serine/threonine-protein kinase WNK</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein kinase with no lysine 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">wnk-1</name>
        <name evidence="18" type="ORF">C46C2.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Choe K.P."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="70" last="75">
            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="18049475"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
            <authorList>
                <person name="Lee E.C."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
            <authorList>
                <person name="Boyd-Shiwarski C.R."/>
                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
            </authorList>
            <dbReference type="PubMed" id="36318922"/>
            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>X5M5N0-16</id>
            <name evidence="20">p</name>
            <sequence type="described" ref="VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-14</id>
            <name evidence="17">m</name>
            <sequence type="described" ref="VSP_057685 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-6</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_057687 VSP_057686 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-15</id>
            <name evidence="19">o</name>
            <sequence type="described" ref="VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-19</id>
            <name evidence="23">s</name>
            <sequence type="described" ref="VSP_057685 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-9</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_057685 VSP_057688 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-1</id>
            <name evidence="18">n</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>X5M5N0-3</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_057687 VSP_057688 VSP_057686 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-10</id>
            <name evidence="13">i</name>
            <sequence type="described" ref="VSP_057684 VSP_057685 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-18</id>
            <name evidence="22">r</name>
            <sequence type="described" ref="VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_057688 VSP_057686 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-11</id>
            <name evidence="14">j</name>
            <sequence type="described" ref="VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-21</id>
            <name evidence="25">u</name>
            <sequence type="described" ref="VSP_057683 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-12</id>
            <name evidence="15">k</name>
            <sequence type="described" ref="VSP_057688 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-8</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_057688 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-13</id>
            <name evidence="16">l</name>
            <sequence type="described" ref="VSP_057688 VSP_057684"/>
        </isoform>
        <isoform>
            <id>X5M5N0-20</id>
            <name evidence="24">t</name>
            <sequence type="described" ref="VSP_057687 VSP_057685 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-7</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_057688 VSP_057684 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-4</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_057685 VSP_057684 VSP_057688 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-17</id>
            <name evidence="21">q</name>
            <sequence type="described" ref="VSP_057686 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-5</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_057686 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-22</id>
            <name evidence="26">v</name>
            <sequence type="described" ref="VSP_057683"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001294038.1">
        <property type="nucleotide sequence ID" value="NM_001307109.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C46C2.1t">
        <property type="protein sequence ID" value="CE49653"/>
        <property type="gene ID" value="WBGene00006941"/>
        <property type="gene designation" value="wnk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="17596296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C46C2.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C46C2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C46C2.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C46C2.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="C46C2.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="C46C2.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="C46C2.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="C46C2.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="C46C2.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="C46C2.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="C46C2.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="C46C2.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="C46C2.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="C46C2.1n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="C46C2.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
            <dbReference type="WormBase" id="C46C2.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
            <dbReference type="WormBase" id="C46C2.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="22">
        <source>
            <dbReference type="WormBase" id="C46C2.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="23">
        <source>
            <dbReference type="WormBase" id="C46C2.1s"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="24">
        <source>
            <dbReference type="WormBase" id="C46C2.1t"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="25">
        <source>
            <dbReference type="WormBase" id="C46C2.1u"/>
        </source>
    </evidence>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
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            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
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        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
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                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
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            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
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                <person name="Lee E.C."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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        <scope>FUNCTION</scope>
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        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
            <authorList>
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                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
            </authorList>
            <dbReference type="PubMed" id="36318922"/>
            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Bristol N2</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
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            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="2" key="3">
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            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
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                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
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    <reference evidence="2" key="4">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
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                <person name="Strange K."/>
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            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
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                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
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            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
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        <scope>ACTIVITY REGULATION</scope>
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            <id>X5M5N0-18</id>
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        <isoform>
            <id>X5M5N0-20</id>
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        <isoform>
            <id>X5M5N0-11</id>
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            <sequence type="described" ref="VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-5</id>
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        </isoform>
        <isoform>
            <id>X5M5N0-10</id>
            <name evidence="13">i</name>
            <sequence type="described" ref="VSP_057684 VSP_057688 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-3</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_057688 VSP_057687 VSP_057686 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-17</id>
            <name evidence="21">q</name>
            <sequence type="described" ref="VSP_057686 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-15</id>
            <name evidence="19">o</name>
            <sequence type="described" ref="VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-22</id>
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            <sequence type="described" ref="VSP_057683"/>
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        <property type="gene ID" value="WBGene00006941"/>
        <property type="gene designation" value="wnk-1"/>
    </dbReference>
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        <property type="component" value="Chromosome IV"/>
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    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18049475"/>
        </source>
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    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="17596296"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
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        <source>
            <dbReference type="WormBase" id="C46C2.1a"/>
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    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C46C2.1b"/>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000312" key="13">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="14">
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            <dbReference type="WormBase" id="C46C2.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="C46C2.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="C46C2.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="C46C2.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="C46C2.1n"/>
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    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="C46C2.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
            <dbReference type="WormBase" id="C46C2.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
            <dbReference type="WormBase" id="C46C2.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="22">
        <source>
            <dbReference type="WormBase" id="C46C2.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="23">
        <source>
            <dbReference type="WormBase" id="C46C2.1s"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="24">
        <source>
            <dbReference type="WormBase" id="C46C2.1t"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="25">
        <source>
            <dbReference type="WormBase" id="C46C2.1u"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="26">
        <source>
            <dbReference type="WormBase" id="C46C2.1v"/>
        </source>
    </evidence>
    <sequence length="200" mass="21546" checksum="C10256A25DBEEAF5" modified="2014-06-11" version="1">MDLESEDPEVIQMIVRHRMEQHKLLEKQRVEIERLRSKIRVPRATSVNPEMIGDDEADTTLTALQSALGNASLSLPASPPPNTEIPDNEGQHHCNSFRCIGDPNDNVSIVNQIKQRLGIIPSSRQSVRSATSSSPSTPPSSSSAPPKSLSSPTKSYVSHCSLSIGYGSTASSEQQQREPSPSATTSSFLSDPATGVIENV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-12-02" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061ACU2-2</accession>
    <name>PIEZ1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isoform a of Piezo-type mechanosensitive ion channel component 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pezo-1</name>
        <name evidence="9" type="ORF">C10C5.1</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2014" name="Structure" volume="22" first="1520" last="1527">
            <title>The structure of a conserved piezo channel domain reveals a topologically distinct beta sandwich fold.</title>
            <authorList>
                <person name="Kamajaya A."/>
                <person name="Kaiser J.T."/>
                <person name="Lee J."/>
                <person name="Reid M."/>
                <person name="Rees D.C."/>
            </authorList>
            <dbReference type="PubMed" id="25242456"/>
            <dbReference type="DOI" id="10.1016/j.str.2014.08.009"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2065-2346</scope>
        <scope>MUTAGENESIS OF MET-2094</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation.</title>
            <authorList>
                <person name="Bai X."/>
                <person name="Bouffard J."/>
                <person name="Lord A."/>
                <person name="Brugman K."/>
                <person name="Sternberg P.W."/>
                <person name="Cram E.J."/>
                <person name="Golden A."/>
            </authorList>
            <dbReference type="PubMed" id="32490809"/>
            <dbReference type="DOI" id="10.7554/elife.53603"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-2405</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <event type="alternative initiation"/>
        <isoform>
            <id>A0A061ACU2-11</id>
            <name evidence="13">k</name>
            <sequence type="described" ref="VSP_060809"/>
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            <id>A0A061ACU2-7</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_060810 VSP_060811"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-8</id>
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            <sequence type="described" ref="VSP_060810"/>
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        <isoform>
            <id>A0A061ACU2-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_060808"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-6</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060811"/>
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        <isoform>
            <id>A0A061ACU2-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060812 VSP_060811"/>
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        <isoform>
            <id>A0A061ACU2-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_060808 VSP_060813"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-4</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060812"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-1</id>
            <name evidence="9">g</name>
            <sequence type="displayed"/>
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        <isoform>
            <id>A0A061ACU2-12</id>
            <name evidence="14">l</name>
            <sequence type="described" ref="VSP_060807"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-3</id>
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        <isoform>
            <id>A0A061ACU2-5</id>
            <name evidence="6">d</name>
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        <text evidence="1">Produced by alternative splicing.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C10C5.1a"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="C10C5.1d"/>
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    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C10C5.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C10C5.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="C10C5.1g"/>
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    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="C10C5.1h"/>
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    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="C10C5.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="C10C5.1j"/>
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    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="C10C5.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="C10C5.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="15">
        <source>
            <dbReference type="PDB" id="4PKE"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="16">
        <source>
            <dbReference type="PDB" id="4PKX"/>
        </source>
    </evidence>
    <sequence length="2438" mass="276345" checksum="9C6FD22DBA4C4657" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-12-02" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061ACU2-3</accession>
    <name>PIEZ1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isoform b of Piezo-type mechanosensitive ion channel component 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pezo-1</name>
        <name evidence="9" type="ORF">C10C5.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2014" name="Structure" volume="22" first="1520" last="1527">
            <title>The structure of a conserved piezo channel domain reveals a topologically distinct beta sandwich fold.</title>
            <authorList>
                <person name="Kamajaya A."/>
                <person name="Kaiser J.T."/>
                <person name="Lee J."/>
                <person name="Reid M."/>
                <person name="Rees D.C."/>
            </authorList>
            <dbReference type="PubMed" id="25242456"/>
            <dbReference type="DOI" id="10.1016/j.str.2014.08.009"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2065-2346</scope>
        <scope>MUTAGENESIS OF MET-2094</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation.</title>
            <authorList>
                <person name="Bai X."/>
                <person name="Bouffard J."/>
                <person name="Lord A."/>
                <person name="Brugman K."/>
                <person name="Sternberg P.W."/>
                <person name="Cram E.J."/>
                <person name="Golden A."/>
            </authorList>
            <dbReference type="PubMed" id="32490809"/>
            <dbReference type="DOI" id="10.7554/elife.53603"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-2405</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <event type="alternative initiation"/>
        <isoform>
            <id>A0A061ACU2-11</id>
            <name evidence="13">k</name>
            <sequence type="described" ref="VSP_060809"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_060810"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-12</id>
            <name evidence="14">l</name>
            <sequence type="described" ref="VSP_060807"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060812 VSP_060811"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-4</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060812"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_060808 VSP_060813"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_060808"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-5</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060812 VSP_060810"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-6</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060811"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-7</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_060811 VSP_060810"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060812 VSP_060810 VSP_060811"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-1</id>
            <name evidence="9">g</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Produced by alternative splicing.</text>
    </comment>
    <dbReference type="RefSeq" id="NP_001255390.2">
        <property type="nucleotide sequence ID" value="NM_001268461.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C10C5.1b">
        <property type="protein sequence ID" value="CE49903"/>
        <property type="gene ID" value="WBGene00007505"/>
        <property type="gene designation" value="pezo-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C10C5.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
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            <dbReference type="PDB" id="4PKE"/>
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    <evidence type="ECO:0007744" key="16">
        <source>
            <dbReference type="PDB" id="4PKX"/>
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</entry>
<entry dataset="Swiss-Prot" created="2020-12-02" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
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    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2014" name="Structure" volume="22" first="1520" last="1527">
            <title>The structure of a conserved piezo channel domain reveals a topologically distinct beta sandwich fold.</title>
            <authorList>
                <person name="Kamajaya A."/>
                <person name="Kaiser J.T."/>
                <person name="Lee J."/>
                <person name="Reid M."/>
                <person name="Rees D.C."/>
            </authorList>
            <dbReference type="PubMed" id="25242456"/>
            <dbReference type="DOI" id="10.1016/j.str.2014.08.009"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2065-2346</scope>
        <scope>MUTAGENESIS OF MET-2094</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation.</title>
            <authorList>
                <person name="Bai X."/>
                <person name="Bouffard J."/>
                <person name="Lord A."/>
                <person name="Brugman K."/>
                <person name="Sternberg P.W."/>
                <person name="Cram E.J."/>
                <person name="Golden A."/>
            </authorList>
            <dbReference type="PubMed" id="32490809"/>
            <dbReference type="DOI" id="10.7554/elife.53603"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-2405</scope>
    </reference>
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<entry dataset="Swiss-Prot" created="2020-12-02" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Bristol N2</strain>
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    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2014" name="Structure" volume="22" first="1520" last="1527">
            <title>The structure of a conserved piezo channel domain reveals a topologically distinct beta sandwich fold.</title>
            <authorList>
                <person name="Kamajaya A."/>
                <person name="Kaiser J.T."/>
                <person name="Lee J."/>
                <person name="Reid M."/>
                <person name="Rees D.C."/>
            </authorList>
            <dbReference type="PubMed" id="25242456"/>
            <dbReference type="DOI" id="10.1016/j.str.2014.08.009"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2065-2346</scope>
        <scope>MUTAGENESIS OF MET-2094</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation.</title>
            <authorList>
                <person name="Bai X."/>
                <person name="Bouffard J."/>
                <person name="Lord A."/>
                <person name="Brugman K."/>
                <person name="Sternberg P.W."/>
                <person name="Cram E.J."/>
                <person name="Golden A."/>
            </authorList>
            <dbReference type="PubMed" id="32490809"/>
            <dbReference type="DOI" id="10.7554/elife.53603"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-2405</scope>
    </reference>
    <comment type="alternative products">
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        <event type="alternative initiation"/>
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<entry dataset="Swiss-Prot" created="2020-12-02" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
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    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2014" name="Structure" volume="22" first="1520" last="1527">
            <title>The structure of a conserved piezo channel domain reveals a topologically distinct beta sandwich fold.</title>
            <authorList>
                <person name="Kamajaya A."/>
                <person name="Kaiser J.T."/>
                <person name="Lee J."/>
                <person name="Reid M."/>
                <person name="Rees D.C."/>
            </authorList>
            <dbReference type="PubMed" id="25242456"/>
            <dbReference type="DOI" id="10.1016/j.str.2014.08.009"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2065-2346</scope>
        <scope>MUTAGENESIS OF MET-2094</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation.</title>
            <authorList>
                <person name="Bai X."/>
                <person name="Bouffard J."/>
                <person name="Lord A."/>
                <person name="Brugman K."/>
                <person name="Sternberg P.W."/>
                <person name="Cram E.J."/>
                <person name="Golden A."/>
            </authorList>
            <dbReference type="PubMed" id="32490809"/>
            <dbReference type="DOI" id="10.7554/elife.53603"/>
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        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-2405</scope>
    </reference>
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        <event type="alternative initiation"/>
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            <id>A0A061ACU2-4</id>
            <name evidence="5">c</name>
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        <text evidence="1">Produced by alternative splicing.</text>
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            <dbReference type="Proteomes" id="UP000001940"/>
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        <source>
            <dbReference type="WormBase" id="C10C5.1a"/>
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        <source>
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        <source>
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    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C10C5.1e"/>
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    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C10C5.1f"/>
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        <source>
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        <source>
            <dbReference type="WormBase" id="C10C5.1h"/>
        </source>
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    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="C10C5.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="C10C5.1j"/>
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    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="C10C5.1k"/>
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    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="C10C5.1l"/>
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    <evidence type="ECO:0007744" key="15">
        <source>
            <dbReference type="PDB" id="4PKE"/>
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    <evidence type="ECO:0007744" key="16">
        <source>
            <dbReference type="PDB" id="4PKX"/>
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    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2020-12-02" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061ACU2-7</accession>
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        <recommendedName>
            <fullName evidence="9">Isoform f of Piezo-type mechanosensitive ion channel component 1</fullName>
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            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2014" name="Structure" volume="22" first="1520" last="1527">
            <title>The structure of a conserved piezo channel domain reveals a topologically distinct beta sandwich fold.</title>
            <authorList>
                <person name="Kamajaya A."/>
                <person name="Kaiser J.T."/>
                <person name="Lee J."/>
                <person name="Reid M."/>
                <person name="Rees D.C."/>
            </authorList>
            <dbReference type="PubMed" id="25242456"/>
            <dbReference type="DOI" id="10.1016/j.str.2014.08.009"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2065-2346</scope>
        <scope>MUTAGENESIS OF MET-2094</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation.</title>
            <authorList>
                <person name="Bai X."/>
                <person name="Bouffard J."/>
                <person name="Lord A."/>
                <person name="Brugman K."/>
                <person name="Sternberg P.W."/>
                <person name="Cram E.J."/>
                <person name="Golden A."/>
            </authorList>
            <dbReference type="PubMed" id="32490809"/>
            <dbReference type="DOI" id="10.7554/elife.53603"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-2405</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <event type="alternative initiation"/>
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        <isoform>
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            <id>A0A061ACU2-4</id>
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        <isoform>
            <id>A0A061ACU2-6</id>
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            <sequence type="described" ref="VSP_060811"/>
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            <id>A0A061ACU2-7</id>
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            <sequence type="described" ref="VSP_060811 VSP_060810"/>
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        <isoform>
            <id>A0A061ACU2-11</id>
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        <source>
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        <source>
            <dbReference type="WormBase" id="C10C5.1e"/>
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        <source>
            <dbReference type="WormBase" id="C10C5.1f"/>
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        <source>
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        <source>
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    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="C10C5.1l"/>
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        <source>
            <dbReference type="PDB" id="4PKE"/>
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    <evidence type="ECO:0007744" key="16">
        <source>
            <dbReference type="PDB" id="4PKX"/>
        </source>
    </evidence>
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<entry dataset="Swiss-Prot" created="2020-12-02" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061ACU2-8</accession>
    <name>PIEZ1_CAEEL</name>
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        <recommendedName>
            <fullName evidence="9">Isoform h of Piezo-type mechanosensitive ion channel component 1</fullName>
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        <name evidence="9" type="primary">pezo-1</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2014" name="Structure" volume="22" first="1520" last="1527">
            <title>The structure of a conserved piezo channel domain reveals a topologically distinct beta sandwich fold.</title>
            <authorList>
                <person name="Kamajaya A."/>
                <person name="Kaiser J.T."/>
                <person name="Lee J."/>
                <person name="Reid M."/>
                <person name="Rees D.C."/>
            </authorList>
            <dbReference type="PubMed" id="25242456"/>
            <dbReference type="DOI" id="10.1016/j.str.2014.08.009"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2065-2346</scope>
        <scope>MUTAGENESIS OF MET-2094</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation.</title>
            <authorList>
                <person name="Bai X."/>
                <person name="Bouffard J."/>
                <person name="Lord A."/>
                <person name="Brugman K."/>
                <person name="Sternberg P.W."/>
                <person name="Cram E.J."/>
                <person name="Golden A."/>
            </authorList>
            <dbReference type="PubMed" id="32490809"/>
            <dbReference type="DOI" id="10.7554/elife.53603"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-2405</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <event type="alternative initiation"/>
        <isoform>
            <id>A0A061ACU2-5</id>
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            <sequence type="described" ref="VSP_060812 VSP_060810"/>
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        <isoform>
            <id>A0A061ACU2-6</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060811"/>
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        <isoform>
            <id>A0A061ACU2-12</id>
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            <sequence type="described" ref="VSP_060807"/>
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            <sequence type="described" ref="VSP_060812 VSP_060811"/>
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        <isoform>
            <id>A0A061ACU2-3</id>
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            <sequence type="described" ref="VSP_060812 VSP_060811 VSP_060810"/>
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        <isoform>
            <id>A0A061ACU2-10</id>
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    </comment>
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    <evidence type="ECO:0000312" key="6">
        <source>
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        <source>
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    <evidence type="ECO:0000312" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="C10C5.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="C10C5.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="C10C5.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="C10C5.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="C10C5.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="C10C5.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="15">
        <source>
            <dbReference type="PDB" id="4PKE"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="16">
        <source>
            <dbReference type="PDB" id="4PKX"/>
        </source>
    </evidence>
    <sequence length="2404" mass="272961" checksum="24B95AC167A954D1" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-12-02" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061ACU2-9</accession>
    <name>PIEZ1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isoform i of Piezo-type mechanosensitive ion channel component 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pezo-1</name>
        <name evidence="9" type="ORF">C10C5.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2014" name="Structure" volume="22" first="1520" last="1527">
            <title>The structure of a conserved piezo channel domain reveals a topologically distinct beta sandwich fold.</title>
            <authorList>
                <person name="Kamajaya A."/>
                <person name="Kaiser J.T."/>
                <person name="Lee J."/>
                <person name="Reid M."/>
                <person name="Rees D.C."/>
            </authorList>
            <dbReference type="PubMed" id="25242456"/>
            <dbReference type="DOI" id="10.1016/j.str.2014.08.009"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2065-2346</scope>
        <scope>MUTAGENESIS OF MET-2094</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation.</title>
            <authorList>
                <person name="Bai X."/>
                <person name="Bouffard J."/>
                <person name="Lord A."/>
                <person name="Brugman K."/>
                <person name="Sternberg P.W."/>
                <person name="Cram E.J."/>
                <person name="Golden A."/>
            </authorList>
            <dbReference type="PubMed" id="32490809"/>
            <dbReference type="DOI" id="10.7554/elife.53603"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-2405</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <event type="alternative initiation"/>
        <isoform>
            <id>A0A061ACU2-7</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_060810 VSP_060811"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-12</id>
            <name evidence="14">l</name>
            <sequence type="described" ref="VSP_060807"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-6</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060811"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_060808"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_060810"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060812 VSP_060811 VSP_060810"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_060813 VSP_060808"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-1</id>
            <name evidence="9">g</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-4</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060812"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-11</id>
            <name evidence="13">k</name>
            <sequence type="described" ref="VSP_060809"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060812 VSP_060811"/>
        </isoform>
        <isoform>
            <id>A0A061ACU2-5</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060812 VSP_060810"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Produced by alternative splicing.</text>
    </comment>
    <dbReference type="RefSeq" id="NP_001255385.2">
        <property type="nucleotide sequence ID" value="NM_001268456.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C10C5.1i">
        <property type="protein sequence ID" value="CE48356"/>
        <property type="gene ID" value="WBGene00007505"/>
        <property type="gene designation" value="pezo-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C10C5.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C10C5.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C10C5.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C10C5.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C10C5.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C10C5.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="C10C5.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="C10C5.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="C10C5.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="C10C5.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="C10C5.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="C10C5.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="15">
        <source>
            <dbReference type="PDB" id="4PKE"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="16">
        <source>
            <dbReference type="PDB" id="4PKX"/>
        </source>
    </evidence>
    <sequence length="1704" mass="193873" checksum="F762A49C4EE31B80" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1E3L0</accession>
    <name>A0A3B1E3L0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrosomal protein CEP104 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cepr-104.2</name>
        <name evidence="5" type="ORF">C06A8.8</name>
        <name evidence="3" type="ORF">CELE_C06A8.8</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="VAY52117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355407.1">
        <property type="nucleotide sequence ID" value="NM_001368604.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1E3L0"/>
    <dbReference type="GeneID" id="182287"/>
    <dbReference type="AGR" id="WB:WBGene00015517"/>
    <dbReference type="CTD" id="182287"/>
    <dbReference type="WormBase" id="C06A8.8h">
        <property type="protein sequence ID" value="CE52754"/>
        <property type="gene ID" value="WBGene00015517"/>
        <property type="gene designation" value="cepr-104.2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015517">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1E3L0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF11">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal protein CEP104 N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VAY52117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C06A8.8h"/>
        </source>
    </evidence>
    <sequence length="275" mass="30901" checksum="5FDCBEDF3D6732DC" modified="2018-12-05" version="1">MPLPFSIISTTSQDVLEDADSDEEAETFYVNWITEKNHSFPQSMVLELEEESLVSSVKLIVHKDYPPSSLTVSLGIPSNHFRNSRGKSYNADYSVRQELSFRDDFHVEYGQKHPKATVFFNSPAKFVRISVHGFSDSDVNHHRQVSILSVIISGAGEILPFDSHLKDEPKQTEMSYIELDKGILLPLKSKPKMRETKTIVGLYDTDSEDEEILFSKEMLNRLRKREAVMKNPQLPTTSAITETIAIDTSCEKSAPVSSSSSSKQQSSVSPPLSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1E3M2</accession>
    <name>A0A3B1E3M2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diacylglycerol kinase</fullName>
            <shortName evidence="7">DAG kinase</shortName>
            <ecNumber evidence="7">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">dgk-5</name>
        <name evidence="10" type="ORF">CELE_K06A1.6</name>
        <name evidence="12" type="ORF">K06A1.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="7"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="VAY52137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355417.1">
        <property type="nucleotide sequence ID" value="NM_001368596.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1E3M2"/>
    <dbReference type="SMR" id="A0A3B1E3M2"/>
    <dbReference type="GeneID" id="174068"/>
    <dbReference type="AGR" id="WB:WBGene00019428"/>
    <dbReference type="CTD" id="174068"/>
    <dbReference type="WormBase" id="K06A1.6e">
        <property type="protein sequence ID" value="CE52708"/>
        <property type="gene ID" value="WBGene00019428"/>
        <property type="gene designation" value="dgk-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019428">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1E3M2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20802">
        <property type="entry name" value="C1_DGK_typeIV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20855">
        <property type="entry name" value="C1_DGK_typeIV_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000022">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000037">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056383">
        <property type="entry name" value="DGKI-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF80">
        <property type="entry name" value="EYE-SPECIFIC DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23578">
        <property type="entry name" value="DGKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="9">
        <location>
            <begin position="627"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="340"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VAY52137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="K06A1.6e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="A0A3B1E3M2"/>
        </source>
    </evidence>
    <sequence length="1150" mass="127886" checksum="9F7AE388458EE3E5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I8M7</accession>
    <name>A0A8D9I8M7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T28A8.5</name>
        <name evidence="2 4" type="ORF">T28A8.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAG8860258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9I8M7"/>
    <dbReference type="AGR" id="WB:WBGene00012111"/>
    <dbReference type="WormBase" id="T28A8.5b">
        <property type="protein sequence ID" value="CE54374"/>
        <property type="gene ID" value="WBGene00012111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053315">
        <property type="entry name" value="Peptidase_C14A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006570">
        <property type="entry name" value="SPK_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23362:SF0">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23362">
        <property type="entry name" value="L-PLASTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04435">
        <property type="entry name" value="SPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00583">
        <property type="entry name" value="SPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPK" evidence="1">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG8860258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T28A8.5b"/>
        </source>
    </evidence>
    <sequence length="217" mass="25087" checksum="75EB8A1B69D166FA" modified="2022-01-19" version="1">MATTSTSTELSRFMSFLVEQVNDATEPMTVQRVFTQFSQLGAGVHSEDYYVRRFHRKLAPKMARWDNFSIEARVRLMFGLDGKVADDFLRQIRIYGAVQLDENRRICHFTSHDGQVKLESTELTELKQQVKEKIGTDDADSLQITDLRTVFEAFFVGITKDYLLKFNFILLGLDCSEFRELQQTVERKINEPEIANKVLLISDIHRVVQGLLSFISH</sequence>
</entry>
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    <accession>A7DT37</accession>
    <name>A7DT37_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Type I restriction endonuclease subunit R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T06D4.1</name>
        <name evidence="2 4" type="ORF">T06D4.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD69653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7DT37"/>
    <dbReference type="IntAct" id="A7DT37">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="A7DT37"/>
    <dbReference type="UCSC" id="T06D4.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020290"/>
    <dbReference type="WormBase" id="T06D4.1b">
        <property type="protein sequence ID" value="CE41157"/>
        <property type="gene ID" value="WBGene00020290"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050580_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020290">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A7DT37">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
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    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD69653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T06D4.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A7DT37"/>
        </source>
    </evidence>
    <sequence length="320" mass="36848" checksum="7E674C0C9A74A75F" modified="2007-09-11" version="1">MGKLAEIRELFARTPEDPAFNTPAGIDDSAMNQFYELIRDCRVVPEDDQTFVPRQALATRIHLIIDSFQARRESEFLRQWCQQNIVCLLYGNPVPEMKDFAYRILIEMLTSSSTWTAELESFANELSRKRGTFINDYWATIRDQNEAGDLDPKRTLFADFRDQHSVFGNVQFDIFRERLAQLEKLWHSQMRMFDVPDKVLCVTGIVTDTMTEMLMGVKDGKPNITPFLKKARIFYRLSDGAETSEAPAEASARASEAPEAPALPPKRSRGIKRKLSEYAEELFESKKPKSDELPTAEQWMYFLQHCLQGPEQDEQRGGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-09-11" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A7DT39</accession>
    <name>A7DT39_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_W03F8.6</name>
        <name evidence="2 4" type="ORF">W03F8.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD65518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122802.1">
        <property type="nucleotide sequence ID" value="NM_001129330.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7DT39"/>
    <dbReference type="PeptideAtlas" id="A7DT39"/>
    <dbReference type="GeneID" id="189159"/>
    <dbReference type="KEGG" id="cel:CELE_W03F8.6"/>
    <dbReference type="UCSC" id="W03F8.6a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020995"/>
    <dbReference type="CTD" id="189159"/>
    <dbReference type="WormBase" id="W03F8.6b">
        <property type="protein sequence ID" value="CE41167"/>
        <property type="gene ID" value="WBGene00020995"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800660at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020995">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A7DT39">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34721:SF8">
        <property type="entry name" value="ACTIVIN_RECP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34721">
        <property type="entry name" value="PROTEIN CBG09734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002707869" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="W03F8.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A7DT39"/>
        </source>
    </evidence>
    <sequence length="112" mass="12172" checksum="97F047E6CA8B6522" modified="2007-09-11" version="1">MTQISAIRLAVFFVLVPTTLAAIQCWVGQETVSNGRRLPTEIGGPYQSVQCNDADFCFNSYVRRHKKGDDSYTITKSCGEVGKCFEDGCIGPGDEKNCCCSDNMCNSSNGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>E3W728</accession>
    <name>E3W728_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C09H10.5</name>
        <name evidence="1" type="ORF">CELE_C09H10.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">Bristol N2</strain>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C09H10.5b"/>
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    </evidence>
    <sequence length="114" mass="13540" checksum="A6FD488CCA832F69" modified="2011-01-11" version="1">MDMSKASQEQFSMFMNLLCITVKDMPITEYYTSYILWEEVEFLEGVKDLLDPTSAFEDRRSSLYHHLGHNFASNCSLKDDNNVRDAHVVVEDHTKFDNYMYDQMTRKEWTSLHL</sequence>
</entry>
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            <strain evidence="1 2">Bristol N2</strain>
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    </dbReference>
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            <dbReference type="EMBL" id="CBX53335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T24B8.3c"/>
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    </evidence>
    <sequence length="19" mass="2556" checksum="CA71C1B97F764AE9" modified="2011-01-11" version="1">MLKERRKEMMRMLMMRKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <begin position="1"/>
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            <begin position="65"/>
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        <location>
            <begin position="140"/>
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        <location>
            <begin position="186"/>
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            <begin position="236"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="E3W732"/>
        </source>
    </evidence>
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</entry>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome II"/>
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            <begin position="1"/>
            <end position="69"/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBX53337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="WormBase" id="T24B8.4c"/>
        </source>
    </evidence>
    <sequence length="106" mass="12021" checksum="7B57CFA2B2E9B5AC" modified="2011-01-11" version="1">MSSNVPPSSLSAREQLFSSSSLPRHHRNSSNQNVINVPISAPWYSRDPIVNPEPPSVGSRRPSKQSTNPYRISFDEFTVPHPSQMRDNIRFNIDLSHDLPLSISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>E3W734</accession>
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            <strain evidence="1 2">Bristol N2</strain>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
    <sequence length="22" mass="2669" checksum="839F7B6C14DA17F7" modified="2011-01-11" version="1">MRDNIRFNIDLSHDLPLSISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>E3W735</accession>
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    <protein>
        <submittedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
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        <name evidence="6 8" type="primary">pix-1</name>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
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    <dbReference type="AGR" id="WB:WBGene00010776"/>
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        <property type="protein sequence ID" value="CE45486"/>
        <property type="gene ID" value="WBGene00010776"/>
        <property type="gene designation" value="pix-1"/>
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        <property type="component" value="Chromosome X"/>
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        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:gonad morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="P:inductive cell migration"/>
        <property type="evidence" value="ECO:0000315"/>
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    </dbReference>
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        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0000315"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="92"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBX53330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="K11E4.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="E3W735"/>
        </source>
    </evidence>
    <sequence length="450" mass="50987" checksum="BA7248647512248E" modified="2011-01-11" version="1">MEPGSGSPLSARAKFQFEGSNNDELSFDKDDIITITQQQEGGWWEGTHEGVTGWFPCAYVTLITEKDKLQRSRSVPNATAKEVVSVGAQPDYRDLVLKSYIESEKEYMQSLLKTLQSLLIPIGASKILTAPEYCTLVGNFEVIYTLKRDLFEQLEREQNEELPKMRVGGMFMNAALELRTALMSYADNHPDAVEVLKKKQKELEKVVKSQDREYKELVLGLSEPLRHVERYYNLLQELERIVPANHPDRGDLQRGSAVFRETKDLCETLRKQKEAQLDFLFVSKVDKVVSASERGSILYVGVANVEYKKADAVDRFVALFTKYIMFFEVTKDMTYDIKEKFTVSGFIVRKKEATEISFDRPNTGEFTLTMVSTGGEVERFLVALAKAENVAIITPTTTILRRPSKNANDTMNQSQTQGAETPLVAKPPLHPPGNSDQQYSMMNKRKSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>E3W736</accession>
    <name>E3W736_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Seven TM Receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">str-118</name>
        <name evidence="2" type="ORF">CELE_F57A8.3</name>
        <name evidence="4" type="ORF">F57A8.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBX53328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256178.1">
        <property type="nucleotide sequence ID" value="NM_001269249.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E3W736"/>
    <dbReference type="SMR" id="E3W736"/>
    <dbReference type="GeneID" id="186429"/>
    <dbReference type="KEGG" id="cel:CELE_F57A8.3"/>
    <dbReference type="AGR" id="WB:WBGene00006169"/>
    <dbReference type="CTD" id="186429"/>
    <dbReference type="WormBase" id="F57A8.3b">
        <property type="protein sequence ID" value="CE45496"/>
        <property type="gene ID" value="WBGene00006169"/>
        <property type="gene designation" value="str-118"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1086781_0_0_1"/>
    <dbReference type="OrthoDB" id="5818029at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E3W736">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF26">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBX53328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F57A8.3b"/>
        </source>
    </evidence>
    <sequence length="256" mass="29757" checksum="EAA8E1E184245ECB" modified="2011-01-11" version="1">MVYSTWSTVTHIFGWFSFFTAIWATITLFVLIEKKSRKEFGGYKNFLRVYCFYAFIFSTIDWVVQPYAVMDINGLGYVFYSENRLFDLGYSLSHLLQILYCGCFIASSSFLSLNFIYRYVSSCHSHYLHYIQDFGLILIIAYCILPFVIWSICVYYIFSPTSEKTEYINMSTMQIENFNISGNPYVGVICYYILTTPLHNYGDVDWWTMGALLGLIIFQIDNRGDSSNIRPGTAKISDILTRRLNYQQPAIPTLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>E3W737</accession>
    <name>E3W737_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase PRP4 homolog</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">PRP4 pre-mRNA-processing factor 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26 28" type="primary">prpf-4</name>
        <name evidence="26" type="ORF">CELE_F22D6.5</name>
        <name evidence="28" type="ORF">F22D6.5</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="22">Interacts with CLK1 C-terminus. Associates with the U5 snRNP and NCOR1 deacetylase complexes. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CBX53319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001250392.1">
        <property type="nucleotide sequence ID" value="NM_001263463.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E3W737"/>
    <dbReference type="SMR" id="E3W737"/>
    <dbReference type="PeptideAtlas" id="E3W737"/>
    <dbReference type="GeneID" id="172443"/>
    <dbReference type="AGR" id="WB:WBGene00004186"/>
    <dbReference type="CTD" id="172443"/>
    <dbReference type="WormBase" id="F22D6.5b">
        <property type="protein sequence ID" value="CE45514"/>
        <property type="gene ID" value="WBGene00004186"/>
        <property type="gene designation" value="prpf-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3967at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004186">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E3W737">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000123">
        <property type="entry name" value="serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 26" id="KW-0418">Kinase</keyword>
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    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="455"/>
            <end position="727"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="84"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CBX53319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="WormBase" id="F22D6.5b"/>
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    </evidence>
    <evidence type="ECO:0007829" key="29">
        <source>
            <dbReference type="PeptideAtlas" id="E3W737"/>
        </source>
    </evidence>
    <sequence length="748" mass="87670" checksum="3BFDC5C068CE13C2" modified="2011-01-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>E3W738</accession>
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        <submittedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
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        <name evidence="4 6" type="primary">mam-5</name>
        <name evidence="4" type="ORF">CELE_T07C12.8</name>
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    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
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        <property type="gene designation" value="mam-5"/>
    </dbReference>
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    <dbReference type="OMA" id="YIQPFDI"/>
    <dbReference type="OrthoDB" id="5914193at2759"/>
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    </dbReference>
    <dbReference type="Bgee" id="WBGene00011572">
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="MAM_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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            <end position="446"/>
        </location>
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            <begin position="29"/>
            <end position="187"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="T07C12.8a"/>
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    </evidence>
    <sequence length="446" mass="49184" checksum="AB227C39E951A6F8" modified="2011-01-11" version="1">MDLLNVKWILLLLFLIYPVYTEISSSSDLNCDFTTTCRWRNSSDVGGHFETTSLLEADAQNRIMPIDENNPKPFAFTAGLMGRMMALLVSEVITCQLGGASLKYWYYKTGLDSQLEVCIRQPPGNKDLSQMRCYDGVSTFGKQWIFRAVELPPIAQPFEIVFKTIYSPPSSVIALDNIVFEATLCESTSGGASEGAGGTFDEVGLPGRSPTQLLDFDGNDVTINQFESVSVPIPTRAVHYGAPTSQKITNPMKDEKRKSNDLRGPRTGPMFASICSNVDCNFDDNTLCNYLTSSTNVSAEDGSLLKKWALSNRSVLNSLTGIPSDLSKGGYFLYAGGTTATPGDTFILSTNQPVTITEPARVDFFVYQAGIRGQFRVCIDDNEDCPVVLEGKDIDVNSQKWKNYYFELNPGQHVLHFVVEGLYNNYVIGLDNIQLLNRFGTSSLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5R0</accession>
    <name>F3Y5R0_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">CTLH domain-containing protein</fullName>
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        <name evidence="3 5" type="primary">gid-1</name>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCA65674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001252409.1">
        <property type="nucleotide sequence ID" value="NM_001265480.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5R0"/>
    <dbReference type="PeptideAtlas" id="F3Y5R0"/>
    <dbReference type="GeneID" id="173332"/>
    <dbReference type="AGR" id="WB:WBGene00013202"/>
    <dbReference type="CTD" id="173332"/>
    <dbReference type="WormBase" id="Y54E5A.7b">
        <property type="protein sequence ID" value="CE45898"/>
        <property type="gene ID" value="WBGene00013202"/>
        <property type="gene designation" value="gid-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028137_0_0_1"/>
    <dbReference type="OrthoDB" id="5809049at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013202">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5R0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="55"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCA65674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y54E5A.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="F3Y5R0"/>
        </source>
    </evidence>
    <sequence length="395" mass="45499" checksum="2BDFC3A173CAFAA1" modified="2011-06-28" version="1">MNKKIHLLENIKMPENFGKQMNRIVSSFLGTTGALATLQKFEETTKPEVPIDHEYYAQRKEITDMILKAARGAEIHEKIEKYFPGLVEDDANVHLLILCLRYIDLANTLHEPPNCFTNSTTGRSPSPTEIRARPPKLLKGSQCKTTKRTREAQRRSANSQVHTPPPVRLTNAKATEELYLKDAKIERFYIDQDTEEEMLHIDGVSMPTKMFVELEKSGQYRKLNYILKMGREIMKVAGEMRGNIAPEARKVVEIATSMVSSPERPAKHPLSFALRRFIANSVVDMICYYVHHKREGKSTKRPRGTSTGEIPGSSSLRMFSELRNLFTGWKGLHIDYSTNDKKMAGIHFVRKMILEEPNFNEKEIIYTDEPMELAHERPDPPPREIIRQQRNEFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5R1</accession>
    <name>F3Y5R1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">gid-1</name>
        <name evidence="1" type="ORF">CELE_Y54E5A.7</name>
        <name evidence="3" type="ORF">Y54E5A.7</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCA65675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001252410.1">
        <property type="nucleotide sequence ID" value="NM_001265481.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5R1"/>
    <dbReference type="PeptideAtlas" id="F3Y5R1"/>
    <dbReference type="GeneID" id="173332"/>
    <dbReference type="AGR" id="WB:WBGene00013202"/>
    <dbReference type="CTD" id="173332"/>
    <dbReference type="WormBase" id="Y54E5A.7c">
        <property type="protein sequence ID" value="CE45949"/>
        <property type="gene ID" value="WBGene00013202"/>
        <property type="gene designation" value="gid-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028137_0_0_1"/>
    <dbReference type="OrthoDB" id="5809049at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013202">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5R1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCA65675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y54E5A.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="F3Y5R1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16175" checksum="57AE2735D482CD01" modified="2011-06-28" version="1">MVSSPERPAKHPLSFALRRFIANSVVDMICYYVHHKREGKSTKRPRGTSTGEIPGSSSLRMFSELRNLFTGWKGLHIDYSTNDKKMAGIHFVRKMILEEPNFNEKEIIYTDEPMELAHERPDPPPREIIRQQRNEFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5R2</accession>
    <name>F3Y5R2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">gid-1</name>
        <name evidence="1" type="ORF">CELE_Y54E5A.7</name>
        <name evidence="3" type="ORF">Y54E5A.7</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCA65676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001252411.1">
        <property type="nucleotide sequence ID" value="NM_001265482.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5R2"/>
    <dbReference type="GeneID" id="173332"/>
    <dbReference type="AGR" id="WB:WBGene00013202"/>
    <dbReference type="CTD" id="173332"/>
    <dbReference type="WormBase" id="Y54E5A.7d">
        <property type="protein sequence ID" value="CE46000"/>
        <property type="gene ID" value="WBGene00013202"/>
        <property type="gene designation" value="gid-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028137_0_0_1"/>
    <dbReference type="OrthoDB" id="5809049at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013202">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5R2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCA65676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y54E5A.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="F3Y5R2"/>
        </source>
    </evidence>
    <sequence length="78" mass="9465" checksum="FA76E72E9E4AC2CB" modified="2011-06-28" version="1">MFSELRNLFTGWKGLHIDYSTNDKKMAGIHFVRKMILEEPNFNEKEIIYTDEPMELAHERPDPPPREIIRQQRNEFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5R6</accession>
    <name>F3Y5R6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">elo-8</name>
        <name evidence="4" type="ORF">CELE_Y47D3A.30</name>
        <name evidence="6" type="ORF">Y47D3A.30</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCA65661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255111.1">
        <property type="nucleotide sequence ID" value="NM_001268182.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5R6"/>
    <dbReference type="GeneID" id="259739"/>
    <dbReference type="AGR" id="WB:WBGene00001246"/>
    <dbReference type="CTD" id="259739"/>
    <dbReference type="WormBase" id="Y47D3A.30b">
        <property type="protein sequence ID" value="CE46115"/>
        <property type="gene ID" value="WBGene00001246"/>
        <property type="gene designation" value="elo-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_963911_0_0_1"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001246">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5R6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003308311" evidence="3">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCA65661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y47D3A.30b"/>
        </source>
    </evidence>
    <sequence length="111" mass="12271" checksum="1019CE1F7414FD3D" modified="2011-06-28" version="1">MLQLILPFIATFSAAAKLARGTRCDANALGLLTLQIGLGVLIILFAEFYWSRVQAFRKKNMKSGGGGTSNSDSSEQESEKVLKKLKARRPSDETVMFENDFPELRSVIFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5R8</accession>
    <name>F3Y5R8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y73F8A.35</name>
        <name evidence="1 3" type="ORF">Y73F8A.35</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCA65684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255871.1">
        <property type="nucleotide sequence ID" value="NM_001268942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5R8"/>
    <dbReference type="GeneID" id="178438"/>
    <dbReference type="AGR" id="WB:WBGene00013539"/>
    <dbReference type="CTD" id="178438"/>
    <dbReference type="WormBase" id="Y73F8A.35b">
        <property type="protein sequence ID" value="CE46006"/>
        <property type="gene ID" value="WBGene00013539"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018076_1_0_1"/>
    <dbReference type="OrthoDB" id="5782315at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013539">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5R8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000198">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCA65684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y73F8A.35b"/>
        </source>
    </evidence>
    <sequence length="570" mass="65645" checksum="3D1CA2DC3D1F215A" modified="2011-06-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5S6</accession>
    <name>F3Y5S6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UNC93-like protein MFSD11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_Y39B6A.29</name>
        <name evidence="7 9" type="ORF">Y39B6A.29</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCA65642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256840.1">
        <property type="nucleotide sequence ID" value="NM_001269911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5S6"/>
    <dbReference type="GeneID" id="189739"/>
    <dbReference type="AGR" id="WB:WBGene00012688"/>
    <dbReference type="CTD" id="189739"/>
    <dbReference type="WormBase" id="Y39B6A.29b">
        <property type="protein sequence ID" value="CE45935"/>
        <property type="gene ID" value="WBGene00012688"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025356_0_1_1"/>
    <dbReference type="OrthoDB" id="5856527at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012688">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5S6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF30">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCA65642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y39B6A.29b"/>
        </source>
    </evidence>
    <sequence length="339" mass="37324" checksum="FAC3FE4F5758AFF8" modified="2011-06-28" version="1">MRDTMVYYQGHGGYLTSHSTRKTIESNINIAWCVGCICLLLSSGILATVTHMTLDSREIMQNLKNSTEFEPVERRFSDLEIKLLFGVFLGASVLGIVNFISCPGKDVTNCIQETKKKGTFMEGFKQTCSALTSKSMLQLFPLFTVLGTSSSFWLSIFTTAMNFTAANSNLTYLAAIYPLSVGVGEIGTALFITQMSRRFKDFSLQPTMLIGAIFSILGFGLVHVSTPYDAPMRPTQEVPLLFGHSYLVISVIGVIVGIGDCCLNSCRSVICALAMPDRRAQAFSISKLYQALGSCVLFFASPIIPLYVYTIGVSIHLIIANVFFNITARRTQTMEKDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5S7</accession>
    <name>F3Y5S7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nhr-145</name>
        <name evidence="5" type="ORF">CELE_Y39B6A.47</name>
        <name evidence="7" type="ORF">Y39B6A.47</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCA65643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256842.1">
        <property type="nucleotide sequence ID" value="NM_001269913.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5S7"/>
    <dbReference type="SMR" id="F3Y5S7"/>
    <dbReference type="GeneID" id="180255"/>
    <dbReference type="AGR" id="WB:WBGene00012703"/>
    <dbReference type="CTD" id="180255"/>
    <dbReference type="WormBase" id="Y39B6A.47b">
        <property type="protein sequence ID" value="CE46086"/>
        <property type="gene ID" value="WBGene00012703"/>
        <property type="gene designation" value="nhr-145"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007368_7_0_1"/>
    <dbReference type="OrthoDB" id="5831438at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012703">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5S7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051152">
        <property type="entry name" value="C.elegans_Orphan_NR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680:SF4">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="99"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCA65643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y39B6A.47b"/>
        </source>
    </evidence>
    <sequence length="350" mass="41373" checksum="DB82925F211CD3E5" modified="2011-06-28" version="1">MCRYCRFEKCKEIGMDAEKVILDYDPTASQKVPVMPKIDKVQENEPAPATSKSHADKITVKIDFTELTEKLKEMFETQKRSSGELSGSLDSDESSTDSVYLNDLQNLTKALNEFQAPIKDKKDIVNLDRADMKKVIYWLNFRVKKYATWYSHATYLIEHLPMNQKFETYRKSWNLLRMFERIAMTWKHYGNEMFEGHFILVSDDTKMIIDKSLIHFEEISDVTDEYFRRLFHPFLNQYMEEVAKPMSELDLTTEEIVFCMVNILGYDASGLTPETIETLHKFKEIIADQMHSYYTNSTNIKMYSHRIMKLMQLVKSITKIAREKSRLRDVIYVFDIYKAEISDPCFFQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G4SJZ3</accession>
    <name>G4SJZ3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF659 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y14H12B.1</name>
        <name evidence="2 4" type="ORF">Y14H12B.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD71678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040824.1">
        <property type="nucleotide sequence ID" value="NM_001047359.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4SJZ3"/>
    <dbReference type="SMR" id="G4SJZ3"/>
    <dbReference type="PeptideAtlas" id="G4SJZ3"/>
    <dbReference type="GeneID" id="173736"/>
    <dbReference type="KEGG" id="cel:CELE_Y14H12B.1"/>
    <dbReference type="AGR" id="WB:WBGene00021191"/>
    <dbReference type="CTD" id="173736"/>
    <dbReference type="WormBase" id="Y14H12B.1c">
        <property type="protein sequence ID" value="CE39810"/>
        <property type="gene ID" value="WBGene00021191"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1112177_0_0_1"/>
    <dbReference type="OrthoDB" id="10407103at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021191">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G4SJZ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD71678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y14H12B.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="G4SJZ3"/>
        </source>
    </evidence>
    <sequence length="150" mass="17224" checksum="264A92B5D52F2B78" modified="2012-01-25" version="2">MVASRKSTQKKAKKEKTPEKEATPEPESPDDSGSEEIDNEMMEEEKQEYKFVYNIVERVPPPQTVFSVGEMGKKLLPELQAKVSLTKRKHKEDYCIACLDYKFVTGECSKAHDDNADRLQKFWKSEFPHTEPLTKAIVLADLTTIAEEWV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-07-22" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>G5EGQ3-2</accession>
    <name>MAX2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform a of Serine/threonine-protein kinase max-2</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Motor axon guidance protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">p21-activated kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">max-2</name>
        <name evidence="8" type="ORF">Y38F1A.10</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2006" name="Development" volume="133" first="4549" last="4559">
            <title>The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance.</title>
            <authorList>
                <person name="Lucanic M."/>
                <person name="Kiley M."/>
                <person name="Ashcroft N."/>
                <person name="L'Etoile N."/>
                <person name="Cheng H.J."/>
            </authorList>
            <dbReference type="PubMed" id="17050621"/>
            <dbReference type="DOI" id="10.1242/dev.02648"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-388</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="Curr. Biol." volume="18" first="808" last="813">
            <title>CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.</title>
            <authorList>
                <person name="Quinn C.C."/>
                <person name="Pfeil D.S."/>
                <person name="Wadsworth W.G."/>
            </authorList>
            <dbReference type="PubMed" id="18499456"/>
            <dbReference type="DOI" id="10.1016/j.cub.2008.04.050"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-388</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000269" last="E1000269">
            <title>A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.</title>
            <authorList>
                <person name="Lucanic M."/>
                <person name="Cheng H.J."/>
            </authorList>
            <dbReference type="PubMed" id="19023419"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000269"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2010" name="Mol. Cell. Biol." volume="30" first="995" last="1003">
            <title>The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response.</title>
            <authorList>
                <person name="Fujiki K."/>
                <person name="Mizuno T."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="20008556"/>
            <dbReference type="DOI" id="10.1128/MCB.01131-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>INTERACTION WITH MLK-1 AND MIG-2</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-388 AND LYS-405</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2013" name="G3 (Bethesda)" volume="3" first="181" last="195">
            <title>Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations.</title>
            <authorList>
                <person name="Peters E.C."/>
                <person name="Gossett A.J."/>
                <person name="Goldstein B."/>
                <person name="Der C.J."/>
                <person name="Reiner D.J."/>
            </authorList>
            <dbReference type="PubMed" id="23390595"/>
            <dbReference type="DOI" id="10.1534/g3.112.004416"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EGQ3-2</id>
            <name evidence="6">a</name>
            <sequence type="described" ref="VSP_057795"/>
        </isoform>
        <isoform>
            <id>G5EGQ3-3</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_057794"/>
        </isoform>
        <isoform>
            <id>G5EGQ3-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_057793"/>
        </isoform>
        <isoform>
            <id>G5EGQ3-1</id>
            <name evidence="8">c</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001076635.1">
        <property type="nucleotide sequence ID" value="NM_001083166.5"/>
    </dbReference>
    <dbReference type="WormBase" id="Y38F1A.10a">
        <property type="protein sequence ID" value="CE40478"/>
        <property type="gene ID" value="WBGene00003144"/>
        <property type="gene designation" value="max-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="20008556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="17050621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="ABF71877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10d"/>
        </source>
    </evidence>
    <sequence length="598" mass="66003" checksum="FAAF6E96B2C350FF" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-07-22" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>G5EGQ3-3</accession>
    <name>MAX2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Serine/threonine-protein kinase max-2</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Motor axon guidance protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">p21-activated kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">max-2</name>
        <name evidence="8" type="ORF">Y38F1A.10</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2006" name="Development" volume="133" first="4549" last="4559">
            <title>The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance.</title>
            <authorList>
                <person name="Lucanic M."/>
                <person name="Kiley M."/>
                <person name="Ashcroft N."/>
                <person name="L'Etoile N."/>
                <person name="Cheng H.J."/>
            </authorList>
            <dbReference type="PubMed" id="17050621"/>
            <dbReference type="DOI" id="10.1242/dev.02648"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-388</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="Curr. Biol." volume="18" first="808" last="813">
            <title>CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.</title>
            <authorList>
                <person name="Quinn C.C."/>
                <person name="Pfeil D.S."/>
                <person name="Wadsworth W.G."/>
            </authorList>
            <dbReference type="PubMed" id="18499456"/>
            <dbReference type="DOI" id="10.1016/j.cub.2008.04.050"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-388</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000269" last="E1000269">
            <title>A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.</title>
            <authorList>
                <person name="Lucanic M."/>
                <person name="Cheng H.J."/>
            </authorList>
            <dbReference type="PubMed" id="19023419"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000269"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2010" name="Mol. Cell. Biol." volume="30" first="995" last="1003">
            <title>The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response.</title>
            <authorList>
                <person name="Fujiki K."/>
                <person name="Mizuno T."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="20008556"/>
            <dbReference type="DOI" id="10.1128/MCB.01131-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>INTERACTION WITH MLK-1 AND MIG-2</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-388 AND LYS-405</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2013" name="G3 (Bethesda)" volume="3" first="181" last="195">
            <title>Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations.</title>
            <authorList>
                <person name="Peters E.C."/>
                <person name="Gossett A.J."/>
                <person name="Goldstein B."/>
                <person name="Der C.J."/>
                <person name="Reiner D.J."/>
            </authorList>
            <dbReference type="PubMed" id="23390595"/>
            <dbReference type="DOI" id="10.1534/g3.112.004416"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EGQ3-3</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_057794"/>
        </isoform>
        <isoform>
            <id>G5EGQ3-2</id>
            <name evidence="6">a</name>
            <sequence type="described" ref="VSP_057795"/>
        </isoform>
        <isoform>
            <id>G5EGQ3-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_057793"/>
        </isoform>
        <isoform>
            <id>G5EGQ3-1</id>
            <name evidence="8">c</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
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    </dbReference>
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        <property type="gene ID" value="WBGene00003144"/>
        <property type="gene designation" value="max-2"/>
    </dbReference>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="20008556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="17050621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="ABF71877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10d"/>
        </source>
    </evidence>
    <sequence length="426" mass="47646" checksum="5DE6C82DE588AC11" modified="2011-12-14" version="1">MFQNSPMMYDWWNDTTKPKHQQPTLNVLSPWGAYFNHIGNELLHLKIASSTVSSGCSSPQQYSSARSVGNSLSNGSVVSTTSSDGDVQLSNKENSNDKSVGDKNGNTTTNKTTVEPPPPEEPPVRVRASHREKLSDSEVLNQLREIVNPSNPLGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDADDLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQIQPGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAKPLSSLIPYIRAVREK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-07-22" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>G5EGQ3-4</accession>
    <name>MAX2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform d of Serine/threonine-protein kinase max-2</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Motor axon guidance protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">p21-activated kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">max-2</name>
        <name evidence="8" type="ORF">Y38F1A.10</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2006" name="Development" volume="133" first="4549" last="4559">
            <title>The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance.</title>
            <authorList>
                <person name="Lucanic M."/>
                <person name="Kiley M."/>
                <person name="Ashcroft N."/>
                <person name="L'Etoile N."/>
                <person name="Cheng H.J."/>
            </authorList>
            <dbReference type="PubMed" id="17050621"/>
            <dbReference type="DOI" id="10.1242/dev.02648"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-388</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="Curr. Biol." volume="18" first="808" last="813">
            <title>CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.</title>
            <authorList>
                <person name="Quinn C.C."/>
                <person name="Pfeil D.S."/>
                <person name="Wadsworth W.G."/>
            </authorList>
            <dbReference type="PubMed" id="18499456"/>
            <dbReference type="DOI" id="10.1016/j.cub.2008.04.050"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-388</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000269" last="E1000269">
            <title>A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.</title>
            <authorList>
                <person name="Lucanic M."/>
                <person name="Cheng H.J."/>
            </authorList>
            <dbReference type="PubMed" id="19023419"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000269"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2010" name="Mol. Cell. Biol." volume="30" first="995" last="1003">
            <title>The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response.</title>
            <authorList>
                <person name="Fujiki K."/>
                <person name="Mizuno T."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="20008556"/>
            <dbReference type="DOI" id="10.1128/MCB.01131-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>INTERACTION WITH MLK-1 AND MIG-2</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-388 AND LYS-405</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2013" name="G3 (Bethesda)" volume="3" first="181" last="195">
            <title>Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations.</title>
            <authorList>
                <person name="Peters E.C."/>
                <person name="Gossett A.J."/>
                <person name="Goldstein B."/>
                <person name="Der C.J."/>
                <person name="Reiner D.J."/>
            </authorList>
            <dbReference type="PubMed" id="23390595"/>
            <dbReference type="DOI" id="10.1534/g3.112.004416"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EGQ3-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_057793"/>
        </isoform>
        <isoform>
            <id>G5EGQ3-1</id>
            <name evidence="8">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EGQ3-3</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_057794"/>
        </isoform>
        <isoform>
            <id>G5EGQ3-2</id>
            <name evidence="6">a</name>
            <sequence type="described" ref="VSP_057795"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
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    <dbReference type="WormBase" id="Y38F1A.10d">
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        <property type="gene ID" value="WBGene00003144"/>
        <property type="gene designation" value="max-2"/>
    </dbReference>
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        <property type="component" value="Chromosome II"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="20008556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="17050621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="ABF71877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10d"/>
        </source>
    </evidence>
    <sequence length="269" mass="30434" checksum="D61C0399CDD91186" modified="2011-12-14" version="1">MKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDADDLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQIQPGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAKPLSSLIPYIRAVREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYS1</accession>
    <name>H2KYS1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hsp-43</name>
        <name evidence="7" type="ORF">C14F11.5</name>
        <name evidence="5" type="ORF">CELE_C14F11.5</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD64542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379672.1">
        <property type="nucleotide sequence ID" value="NM_001392785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYS1"/>
    <dbReference type="SMR" id="H2KYS1"/>
    <dbReference type="IntAct" id="H2KYS1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="H2KYS1"/>
    <dbReference type="GeneID" id="180895"/>
    <dbReference type="AGR" id="WB:WBGene00002024"/>
    <dbReference type="CTD" id="180895"/>
    <dbReference type="WormBase" id="C14F11.5a">
        <property type="protein sequence ID" value="CE03986"/>
        <property type="gene ID" value="WBGene00002024"/>
        <property type="gene designation" value="hsp-43"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064155_0_0_1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="PhylomeDB" id="H2KYS1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002024">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYS1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF10">
        <property type="entry name" value="SHSP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="96"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD64542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C14F11.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYS1"/>
        </source>
    </evidence>
    <sequence length="368" mass="43242" checksum="5B72CCC95186C160" modified="2012-03-21" version="1">MTLATRHADFTRDKLWKENDLWLDDFRDWPLDWPKPRDFFHRFSRDVDSWWKDWPTDWPRMDAVMPRFSSQLDRMDRNWRSDPYWMNLYPRWAEPIFKEGIDVNSNVVNDDRRFAVDMDCYQFRPEEIQVKTLDDTLMIEGRHEDIRDKDNFTKMYFVRKYQLPRDVDFNSIQSSIDAKGRLQVEAGKFNNMALQGRERMIPIEGAGHHSPRFENGTLRSQRGPNSPIHVQTEHDGRSVSSRSGSRLNDSPGSRDVYSSHSYSYHRSDSRNRLSPNDVNITRNDNRTYSPVTPRITTSGSYNTAGNANLHEERSSSRAQSHRSESRNGGYRVESPVSTTTGILRNGNSDSPNSTQREYRSIQILRKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYS2</accession>
    <name>H2KYS2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AIP3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C14F11.4</name>
        <name evidence="2" type="ORF">CELE_C14F11.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD64547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024397.2">
        <property type="nucleotide sequence ID" value="NM_001029226.8"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYS2"/>
    <dbReference type="SMR" id="H2KYS2"/>
    <dbReference type="PeptideAtlas" id="H2KYS2"/>
    <dbReference type="GeneID" id="182619"/>
    <dbReference type="AGR" id="WB:WBGene00015780"/>
    <dbReference type="CTD" id="182619"/>
    <dbReference type="WormBase" id="C14F11.4b">
        <property type="protein sequence ID" value="CE42721"/>
        <property type="gene ID" value="WBGene00015780"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_724088_0_0_1"/>
    <dbReference type="OrthoDB" id="5809356at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015780">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYS2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD64547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C14F11.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYS2"/>
        </source>
    </evidence>
    <sequence length="380" mass="42753" checksum="FA3D230A619E3489" modified="2012-03-21" version="1">MSRYPPLVTKKEIIYRRFIDDHNERFDNIVRNPTSYPPRAPKPERPQNLVVSHNYHSDVEAEYQLSKINKKLDRIIEILRSPSTKKTSQEPPIIDVARQEQTRQYKDICDRLDKLEAELTFVAPLQNEISLLTNKVHELAQIQEGLRVKLVSSNIAGEDIDELLKVINETRRDMEEKIGNIKQLSDGNYIHLEDKLDGYLRNQHGIQLQVDHLMQLLTHSSRPASAIGSRPGSAAEKMSSVSRSSSKSSNLKANLVMPTRRSPPPKTPSEASYASTRPKTERSSSHKSASTVTSSATITTLDSAKRKPLAKNASPKPPRSPVLEVLERTKSIETMNEIHTSQKLDELAIETSSSGSYIAPLPINGRRDSQPANILLTQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYT1</accession>
    <name>H2KYT1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">math-14</name>
        <name evidence="5" type="ORF">C16C4.4</name>
        <name evidence="3" type="ORF">CELE_C16C4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD64663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254044.1">
        <property type="nucleotide sequence ID" value="NM_001267115.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYT1"/>
    <dbReference type="IntAct" id="H2KYT1">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="182658"/>
    <dbReference type="AGR" id="WB:WBGene00015828"/>
    <dbReference type="CTD" id="182658"/>
    <dbReference type="WormBase" id="C16C4.4a">
        <property type="protein sequence ID" value="CE08200"/>
        <property type="gene ID" value="WBGene00015828"/>
        <property type="gene designation" value="math-14"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086152_0_0_1"/>
    <dbReference type="PhylomeDB" id="H2KYT1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015828">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYT1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46308">
        <property type="entry name" value="MATH (MEPRIN-ASSOCIATED TRAF HOMOLOGY) DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46308:SF1">
        <property type="entry name" value="MATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00917">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="103"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD64663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C16C4.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYT1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31967" checksum="90E045EC4E479ECF" modified="2012-03-21" version="1">MCIAKCDDEFSLGLKCEKNNWDNREWSIETDWTMKLVSHNGKSLMESKKFTFNNSNIFDGGLNTSWDLLESDYVVDDSVVVEAHVKIIKITDLPCDEDEDSKTFLLSSTVRNISSIEEGDDYYTETTIRHNIPWRMQIKRDDGFFGLFLRCEKEDCEDPGKSWSIELDYELRLVSLNGQSLTFSDSDLFIYPSGEGFQKFMRWDDMEEKYMVNGSIIIEARGKITSLEESDDESSSENEEDDSSESHSENDSSSDNLEDEFSECVINVGGQNYTVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYT2</accession>
    <name>H2KYT2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C16C4.17</name>
        <name evidence="1" type="ORF">CELE_C16C4.17</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD64664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254042.1">
        <property type="nucleotide sequence ID" value="NM_001267113.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYT2"/>
    <dbReference type="GeneID" id="3565080"/>
    <dbReference type="AGR" id="WB:WBGene00044359"/>
    <dbReference type="CTD" id="3565080"/>
    <dbReference type="WormBase" id="C16C4.17a">
        <property type="protein sequence ID" value="CE38683"/>
        <property type="gene ID" value="WBGene00044359"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2591944_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044359">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYT2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD64664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C16C4.17a"/>
        </source>
    </evidence>
    <sequence length="50" mass="5186" checksum="F8DFDBBFEA266424" modified="2012-03-21" version="1">MGPIQIESTDSGFPPGVAAEVQLQVPATTTVVKEGTRGLFDGIMNSFFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYT4</accession>
    <name>H2KYT4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prion-like-(Q/N-rich)-domain-bearing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_F14B8.5</name>
        <name evidence="4 6" type="ORF">F14B8.5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD64776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_509171.3">
        <property type="nucleotide sequence ID" value="NM_076770.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYT4"/>
    <dbReference type="GeneID" id="180965"/>
    <dbReference type="AGR" id="WB:WBGene00017447"/>
    <dbReference type="CTD" id="180965"/>
    <dbReference type="WormBase" id="F14B8.5b">
        <property type="protein sequence ID" value="CE39147"/>
        <property type="gene ID" value="WBGene00017447"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017447">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYT4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0640">Prion</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564312" evidence="3">
        <location>
            <begin position="19"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD64776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F14B8.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYT4"/>
        </source>
    </evidence>
    <sequence length="501" mass="54463" checksum="2C5931B98B0543F9" modified="2012-03-21" version="1">MRVIALFVVLGLLGIGYAQYQQAQFQGGQQRGGGYQQGGFQSGGGSQSIQGVQQGGGYGYGGVSGYQSQYGSQSGYGGQMGGQFGSPGRTVYSNNPMALETGSGLMGAEVDLRLISYTNSGLKLPNGTTCNCPISNCNFVPSNHQNQCQFSFVLVISCADQSIQYTQSNFYPVPNNGIITTGNWTNQHTFYMATKPISIDVFVQHLGVVIDSSSGQLLFFNHLSLVDSFVVDLSKFSTNTGNQGQGTQTLTLTGTSLQTQLQMNLNVQCINNFMGPLCDLTCNKTNAQANHLVACFSNRTGTFSLCKWNTQLTQVVECNPCTYGVYNGACAAAVNVNNVGVAYAFRTWTIVLGCLLGIALLLILCLILAYLIILNRSYPKEQYEEEYVVDKKIDVIDQHDKKRAAGSDHGSDQPLITNEEWSSTTAKRKPVGILHQTQNQNHLINQNHQTNQNHQIHLNGSVHNGEPRLDSPSTEDSYMANGQVQHTTTTTTTTTRREQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYT6</accession>
    <name>H2KYT6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Palmitoyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="ORF">C17C3.1</name>
        <name evidence="7" type="ORF">CELE_C17C3.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD64830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_495079.1">
        <property type="nucleotide sequence ID" value="NM_062678.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYT6"/>
    <dbReference type="SMR" id="H2KYT6"/>
    <dbReference type="GeneID" id="173942"/>
    <dbReference type="AGR" id="WB:WBGene00015887"/>
    <dbReference type="CTD" id="173942"/>
    <dbReference type="WormBase" id="C17C3.1b">
        <property type="protein sequence ID" value="CE27071"/>
        <property type="gene ID" value="WBGene00015887"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032690_1_0_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015887">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYT6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.210:FF:000001">
        <property type="entry name" value="Acyl-CoA thioesterase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00189">
        <property type="entry name" value="tesB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="5">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="6">
        <location>
            <begin position="226"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD64830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C17C3.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYT6"/>
        </source>
    </evidence>
    <sequence length="346" mass="39688" checksum="CF853F9CAF0B93B2" modified="2012-03-21" version="1">MSFVRRLLPVVTATISRRGIMTTVPLKSEFKKVNNFQEIAHKFFDFTELKKDSFSPSTLSNGRQAHHGAAYGGLIFSQALAAAEKTVDEQFKPHSMHSYFILNVDTKEPISYNVRRIRDGRSFITRTVEAVQKDKVCFVLQCSFHVEEKSSIIHQSEMPKVPEPEVLMSMRDAVPYMKELVEKGEVTPPPAMLARLQSYDSKVYSDDQDLFEMRCTNLGNYYGFASDKKPELYFWMRARGDLSNDERFHRWLIAYNSDSLLVSTAVSPHYTTGFCSSMLFSLDHCVWFHRSEVKADEWLLFECKSRIASGSRATIEGRIWRRDGVLIASCQQEALVRSKSDEPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYT7</accession>
    <name>H2KYT7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-coenzyme A thioesterase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C17C3.1</name>
        <name evidence="2" type="ORF">CELE_C17C3.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD64831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367517.1">
        <property type="nucleotide sequence ID" value="NM_001381419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYT7"/>
    <dbReference type="GeneID" id="173942"/>
    <dbReference type="AGR" id="WB:WBGene00015887"/>
    <dbReference type="CTD" id="173942"/>
    <dbReference type="WormBase" id="C17C3.1c">
        <property type="protein sequence ID" value="CE27072"/>
        <property type="gene ID" value="WBGene00015887"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2943917_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015887">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYT7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD64831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C17C3.1c"/>
        </source>
    </evidence>
    <sequence length="60" mass="7054" checksum="CA8069E3967A80F0" modified="2012-03-21" version="1">MFVKNVNWDSDIRHLEPLGNSWEVPSNHPVYVLLFQKTAHFQIVSLLLSINLFNSQMKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYT8</accession>
    <name>H2KYT8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-coenzyme A thioesterase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C17C3.1</name>
        <name evidence="1" type="ORF">CELE_C17C3.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD64832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_495077.1">
        <property type="nucleotide sequence ID" value="NM_062676.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYT8"/>
    <dbReference type="GeneID" id="173942"/>
    <dbReference type="AGR" id="WB:WBGene00015887"/>
    <dbReference type="CTD" id="173942"/>
    <dbReference type="WormBase" id="C17C3.1d">
        <property type="protein sequence ID" value="CE27073"/>
        <property type="gene ID" value="WBGene00015887"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3360203_0_0_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015887">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYT8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD64832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C17C3.1d"/>
        </source>
    </evidence>
    <sequence length="36" mass="4225" checksum="BADC5913E4893196" modified="2012-03-21" version="1">MFVKNVNWDSDIRHLEPLGNSWEVPNCFSTSVNQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYT9</accession>
    <name>H2KYT9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">acdh-2</name>
        <name evidence="11" type="ORF">C17C3.12</name>
        <name evidence="9" type="ORF">CELE_C17C3.12</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD64843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_495066.2">
        <property type="nucleotide sequence ID" value="NM_062665.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYT9"/>
    <dbReference type="SMR" id="H2KYT9"/>
    <dbReference type="PaxDb" id="6239-C17C3.12a.1"/>
    <dbReference type="PeptideAtlas" id="H2KYT9"/>
    <dbReference type="GeneID" id="173940"/>
    <dbReference type="AGR" id="WB:WBGene00015894"/>
    <dbReference type="CTD" id="173940"/>
    <dbReference type="WormBase" id="C17C3.12a">
        <property type="protein sequence ID" value="CE34697"/>
        <property type="gene ID" value="WBGene00015894"/>
        <property type="gene designation" value="acdh-2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_7_2_1"/>
    <dbReference type="OMA" id="RTYLDDC"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="PhylomeDB" id="H2KYT9"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015894">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYT9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000086">
        <property type="entry name" value="Acyl CoA DeHydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000043">
        <property type="entry name" value="Acyl CoA DeHydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000026">
        <property type="entry name" value="Acyl-CoA dehydrogenase medium chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF6">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="38"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="152"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="259"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD64843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C17C3.12a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYT9"/>
        </source>
    </evidence>
    <sequence length="308" mass="34008" checksum="933DF7C9E033E042" modified="2012-03-21" version="1">MFKVPRKLPISAISTFSTTGSISAQQQPRVFPLQHLNENEKKLVEKVKNFAQSSVKPLVREMDRDARINKQLLKKAFDLKLMGLKIDPKYGGSGVSFFELVLAVEELSKIDPAIALIMHLQNALVAPLIEEFGNEELKEKYLKKLCKDSVGAFALSEVVSGSDAFAMQTVAKKDGDHFILNGSKWGISNAPIADFFLVLANADPEKGYRGVTCFIVDRDHEGVVLGEQDDNLGMRAGTIAQVHLNSVRVPKTSIVGEYGKGYKYAIEVLNASRIVIGAQMVGLAQGCFDQTIPYLQERKQFGSRLIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ50</accession>
    <name>H2KZ50_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T10B11.8</name>
        <name evidence="2 4" type="ORF">T10B11.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD66248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_871832.2">
        <property type="nucleotide sequence ID" value="NM_182032.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ50"/>
    <dbReference type="GeneID" id="172425"/>
    <dbReference type="AGR" id="WB:WBGene00020404"/>
    <dbReference type="CTD" id="172425"/>
    <dbReference type="WormBase" id="T10B11.8b">
        <property type="protein sequence ID" value="CE43979"/>
        <property type="gene ID" value="WBGene00020404"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875272at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020404">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ50">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22670:SF8">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22670">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD66248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T10B11.8b"/>
        </source>
    </evidence>
    <sequence length="467" mass="53837" checksum="FE6DDB669E2B9C2D" modified="2012-03-21" version="1">MEKSNENFSSEKEKRSLVLRVLNEASLSSLSISHQKAFRPTMTLLSRFDKTTDDAAIEVSKYIIKYETEVLDQINVNGLIVLVSMNLLIHEKAPIVNLAIKWLLLHELEAPIMNALLMSIAVQNMTFTKVAKIRLAIQMYVTIPQLRDHYDIHLNKHGLIIAHRKSLPGEPEAYNKEQRISLCRKLNEITDKNINPFWPAGSWRKDYEKPKLNKNGNIRFPKKVMSEEKLENPLFHLTFESSQIAVEEPPKPKSTSTGDFTRAREEKLNMKKKKKSTSSGSKSASTSSGYQSNSHSSDSSSSSGQTVFEYEIKRNNDKKNSHDRPSDPHSSQPKQRDLENRYNHYTNSFDNYRMGNEQTTSYDHHPIPVNVRRLYPLQSHKNIIKQDTWPHEKNKEKYDFNLKNVEKKNDSTKSDRKSHFSDVSISLGFGKEDWNEKNKSVKDLSGRSHPKLHFGVTRNTFGMNSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ55</accession>
    <name>H2KZ55_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-box C protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">fbxc-40</name>
        <name evidence="3" type="ORF">C32B5.1</name>
        <name evidence="1" type="ORF">CELE_C32B5.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD66346.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370529.1">
        <property type="nucleotide sequence ID" value="NM_001383782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ55"/>
    <dbReference type="GeneID" id="173477"/>
    <dbReference type="AGR" id="WB:WBGene00016295"/>
    <dbReference type="CTD" id="173477"/>
    <dbReference type="WormBase" id="C32B5.1b">
        <property type="protein sequence ID" value="CE51208"/>
        <property type="gene ID" value="WBGene00016295"/>
        <property type="gene designation" value="fbxc-40"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5910309at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016295">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ55">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021942">
        <property type="entry name" value="DUF3557"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31379:SF1">
        <property type="entry name" value="F-BOX C PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31379">
        <property type="entry name" value="F-BOX C PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12078">
        <property type="entry name" value="DUF3557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD66346.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C32B5.1b"/>
        </source>
    </evidence>
    <sequence length="328" mass="38042" checksum="DE3DD35EB65545C1" modified="2016-02-17" version="2">MATSRIELSLRCPSLRSINQSTPLEIETLSVNFSGLIINSHKYYLQIVEINTNDVYIKSGELHGKKLPHQLRPFTNCSPGTYIGFENDTDSIEWATSSKDRKEAVAYLYERVLGNRNIPIKVSKLDINSNTVYLEGLRNLKLSVSELELDDYTGRTQLLSSIALYLDPSNFPLKCLRLPKFLMGWEKDGMLNHQVIQTAKLLTINGFPQYIHKISTRIVRVHLDLIKSNWDISFISEKLIKLIDHWLDIGKEVGTRFSFVWSATRMNAARDIWKAIRDKFIFRIRETQRTDDCFEPLKIPSRFYSETWVSIRRGSGYEWICNLEVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ57</accession>
    <name>H2KZ57_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">clec-88</name>
        <name evidence="5" type="ORF">CELE_K10B2.3</name>
        <name evidence="7" type="ORF">K10B2.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD66395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_872010.1">
        <property type="nucleotide sequence ID" value="NM_182210.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ57"/>
    <dbReference type="SMR" id="H2KZ57"/>
    <dbReference type="PeptideAtlas" id="H2KZ57"/>
    <dbReference type="GeneID" id="174056"/>
    <dbReference type="AGR" id="WB:WBGene00019606"/>
    <dbReference type="CTD" id="174056"/>
    <dbReference type="WormBase" id="K10B2.3b">
        <property type="protein sequence ID" value="CE33420"/>
        <property type="gene ID" value="WBGene00019606"/>
        <property type="gene designation" value="clec-88"/>
    </dbReference>
    <dbReference type="OMA" id="HICNIKT"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="PhylomeDB" id="H2KZ57"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019606">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ57">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051379">
        <property type="entry name" value="C-type_Lectin_Receptor_IMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46746:SF9">
        <property type="entry name" value="CD209 ANTIGEN-LIKE PROTEIN C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46746">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564225" evidence="3">
        <location>
            <begin position="19"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="88"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD66395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="K10B2.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ57"/>
        </source>
    </evidence>
    <sequence length="243" mass="27962" checksum="954573D8886464CD" modified="2012-03-21" version="1">MQFIFFGTLFSGLLLVCAVTNDIEDASGETPGIVSQITEEQPHQRQKLYNWDYKDLGTIAFEDIPFPTLQPSQTIDQSENCPEGWIRYSDSCYWVETELLGFAKAERKCSEKQSTLFVANSIDEWEAIRGHSKDSFSSWIGLVRFSHYERSEQLPRWQTEGAVNPSKMCVYFASVLFQRKKFRNWLIKPYSPLVNGWSQLANCAASYKSPASLETASYTYFYPCTYLFYSICERNSTIANSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZS3</accession>
    <name>H2KZS3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T23E7.2</name>
        <name evidence="2 4" type="ORF">T23E7.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD83562.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZS3"/>
    <dbReference type="PeptideAtlas" id="H2KZS3"/>
    <dbReference type="AGR" id="WB:WBGene00020732"/>
    <dbReference type="WormBase" id="T23E7.2b">
        <property type="protein sequence ID" value="CE53553"/>
        <property type="gene ID" value="WBGene00020732"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_321892_0_0_1"/>
    <dbReference type="OrthoDB" id="5870358at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020732">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZS3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD83562.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T23E7.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZS3"/>
        </source>
    </evidence>
    <sequence length="938" mass="102254" checksum="76565CD175150FB3" modified="2019-11-13" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZS4</accession>
    <name>H2KZS4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_T23E7.2</name>
        <name evidence="1 3" type="ORF">T23E7.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD83563.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_510853.2">
        <property type="nucleotide sequence ID" value="NM_078452.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZS4"/>
    <dbReference type="SMR" id="H2KZS4"/>
    <dbReference type="PeptideAtlas" id="H2KZS4"/>
    <dbReference type="GeneID" id="181789"/>
    <dbReference type="AGR" id="WB:WBGene00020732"/>
    <dbReference type="CTD" id="181789"/>
    <dbReference type="WormBase" id="T23E7.2c">
        <property type="protein sequence ID" value="CE50354"/>
        <property type="gene ID" value="WBGene00020732"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10351226at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020732">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZS4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD83563.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T23E7.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZS4"/>
        </source>
    </evidence>
    <sequence length="132" mass="15828" checksum="13021B2E79DB97AE" modified="2015-11-11" version="2">MYLFSKKRIFRQKFDLGRIGQLERSLSREVIQKDRLRTEYQQLSTKLDQACRQMELLSPYTPPNMEDHRLINRPEIRRSIAYTLDLRATGLPSTERWRLGNVVYGGLYRKKYDADLEKAVQYYSSCAKKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZS5</accession>
    <name>H2KZS5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_T23E7.2</name>
        <name evidence="1 3" type="ORF">T23E7.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD83564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZS5"/>
    <dbReference type="PeptideAtlas" id="H2KZS5"/>
    <dbReference type="AGR" id="WB:WBGene00020732"/>
    <dbReference type="WormBase" id="T23E7.2d">
        <property type="protein sequence ID" value="CE24008"/>
        <property type="gene ID" value="WBGene00020732"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2075278_0_0_1"/>
    <dbReference type="OrthoDB" id="5870358at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020732">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZS5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD83564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T23E7.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZS5"/>
        </source>
    </evidence>
    <sequence length="118" mass="14241" checksum="17EAA757E18F6D43" modified="2012-03-21" version="1">MPFFSEHTLILIKNTFYVQYCIPYFFYYPFYLYNVYTLSLITKSPYTPPNMEDHRLINRPEIRRSIAYTLDLRATGLPSTERWRLGNVVYGGLYRKKYDADLEKAVQYYSSCAKKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZS6</accession>
    <name>H2KZS6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuropeptide-Like Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nlp-6</name>
        <name evidence="2" type="ORF">CELE_T23E7.4</name>
        <name evidence="4" type="ORF">T23E7.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD83566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257288.1">
        <property type="nucleotide sequence ID" value="NM_001270359.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZS6"/>
    <dbReference type="GeneID" id="188798"/>
    <dbReference type="AGR" id="WB:WBGene00003744"/>
    <dbReference type="CTD" id="188798"/>
    <dbReference type="WormBase" id="T23E7.4a">
        <property type="protein sequence ID" value="CE38554"/>
        <property type="gene ID" value="WBGene00003744"/>
        <property type="gene designation" value="nlp-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174246_0_0_1"/>
    <dbReference type="OrthoDB" id="10067964at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003744">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZS6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003563895" evidence="1">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD83566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T23E7.4a"/>
        </source>
    </evidence>
    <sequence length="86" mass="9583" checksum="4AABCD98786A1312" modified="2012-03-21" version="1">MLSFSRLAFVLLVSACVMAMAAPKQMVFGFGKRSMADISDMPEDVPMKRYKPRSFAMGFGKRAAMRSFNMGFGKRSAEPQIDVDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZS7</accession>
    <name>H2KZS7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rga-4</name>
        <name evidence="3" type="ORF">CELE_Y75B7AL.4</name>
        <name evidence="5" type="ORF">Y75B7AL.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD69561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041202.1">
        <property type="nucleotide sequence ID" value="NM_001047737.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZS7"/>
    <dbReference type="SMR" id="H2KZS7"/>
    <dbReference type="PeptideAtlas" id="H2KZS7"/>
    <dbReference type="GeneID" id="178629"/>
    <dbReference type="AGR" id="WB:WBGene00022286"/>
    <dbReference type="CTD" id="178629"/>
    <dbReference type="WormBase" id="Y75B7AL.4b">
        <property type="protein sequence ID" value="CE39305"/>
        <property type="gene ID" value="WBGene00022286"/>
        <property type="gene designation" value="rga-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_977391_0_0_1"/>
    <dbReference type="OrthoDB" id="29546at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022286">
        <property type="expression patterns" value="Expressed in embryo and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZS7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045167">
        <property type="term" value="P:asymmetric protein localization involved in cell fate determination"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032970">
        <property type="term" value="P:regulation of actin filament-based process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042869">
        <property type="entry name" value="ARHGAP11A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="47"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD69561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y75B7AL.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZS7"/>
        </source>
    </evidence>
    <sequence length="285" mass="31436" checksum="70A4BCD76F034E4D" modified="2012-03-21" version="1">MEHNDFRVVTSSSVYRKGSTTTAGAAAAGPKSNKLSYTLGEVCSTNVTLDVNVGTGWTRIRLKEVPKFIVHAFNIISKHGMDTDGIFRKEGNSVRLNRAEVQAIYKGQSDIPNDYSVIDVCTMVKRFLRDLKPPLLDSEECRARLLKKACQARISDSFLMTRDEMADIFYLEDRTIEQQTPLLSDVHASTLGYVMRQLYREIEHSQRVETSMSGRLSAMSQSSLRSSNDTHQSSSDRFSDVSDLRNAAFSESTSDSALSTPTATPTTSRVSTNDAAAAAAAAQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZS8</accession>
    <name>H2KZS8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F16B4.2</name>
        <name evidence="2 4" type="ORF">F16B4.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD69566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023809.1">
        <property type="nucleotide sequence ID" value="NM_001028638.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZS8"/>
    <dbReference type="PeptideAtlas" id="H2KZS8"/>
    <dbReference type="GeneID" id="178649"/>
    <dbReference type="KEGG" id="cel:CELE_F16B4.2"/>
    <dbReference type="AGR" id="WB:WBGene00017504"/>
    <dbReference type="CTD" id="178649"/>
    <dbReference type="WormBase" id="F16B4.2a">
        <property type="protein sequence ID" value="CE17012"/>
        <property type="gene ID" value="WBGene00017504"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_765556_0_0_1"/>
    <dbReference type="OrthoDB" id="5803794at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017504">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZS8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042317">
        <property type="entry name" value="She-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31006:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31006">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD69566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F16B4.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZS8"/>
        </source>
    </evidence>
    <sequence length="362" mass="42255" checksum="33D99EF0FD114006" modified="2012-03-21" version="1">MLRRRIHEILSRKFPKWVFEERLEPLDWSFLPVEIRREVVKHTDFQTRCRLRQCSLQDQQIVDSLLIELPFVRIETDKNYVSVLICESKTSILRIDLAKRKIRLRKKFVMNISDNILGKNAKEVQINHEFDTIIESLLNAISRINVSVSSLNLYIKYPIDAVINYLDVQFRQQTGPKRKTKIICSGMEFLMGQVHFLPVDEVRVINDLITNYEEGRMMLAGKKYNVSPSGHYAEIGETAFWKPTLLNCNLGALIAGIIWKINTEMECYCIPGLDVPEYQEYCARFEGQITEYRNTRVLHIPVPETTRKLFVLINKCGVVIQKANIDDVVHIPKEKCILDWTCSTCDKTIESWYFRSTLGMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZS9</accession>
    <name>H2KZS9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterogeneous nuclear ribonucleoprotein A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F16B4.5</name>
        <name evidence="3 5" type="ORF">F16B4.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD69570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZS9"/>
    <dbReference type="AGR" id="WB:WBGene00017507"/>
    <dbReference type="WormBase" id="F16B4.5a">
        <property type="protein sequence ID" value="CE17015"/>
        <property type="gene ID" value="WBGene00017507"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2673334_0_0_1"/>
    <dbReference type="OMA" id="IVWAKPH"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017507">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZS9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564253" evidence="2">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD69570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F16B4.5a"/>
        </source>
    </evidence>
    <sequence length="76" mass="7465" checksum="E47E5764116DF220" modified="2012-03-21" version="1">MKFLILLLAVLAIVTAKPHPGYGRPSYGGGDFGGGGGQWGSQSSSFQQNQMSGGFQNGGGFGGGMGGGSGGYGYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>H9G300</accession>
    <name>H9G300_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">TransThyretin-Related family domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F11E6.4</name>
        <name evidence="2 4" type="ORF">F11E6.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255964.1">
        <property type="nucleotide sequence ID" value="NM_001269035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G300"/>
    <dbReference type="GeneID" id="184358"/>
    <dbReference type="AGR" id="WB:WBGene00008708"/>
    <dbReference type="CTD" id="184358"/>
    <dbReference type="WormBase" id="F11E6.4b">
        <property type="protein sequence ID" value="CE47255"/>
        <property type="gene ID" value="WBGene00008708"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5869907at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008708">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G300">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37427:SF3">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37427">
        <property type="entry name" value="PROTEIN CBG20963-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003620737" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F11E6.4b"/>
        </source>
    </evidence>
    <sequence length="119" mass="13623" checksum="7CD7DAD0B5D43BCD" modified="2012-05-16" version="1">MYSKFFALFFAIPFSITACDITATMTSQTYHLVYAQFTFHNETRSPVYQFNQDGEMKTVHITGTFCNMKPTRLDAYKTYPKLGDKPCGSSQAFIEGFGYVNYVVRSKLCTLCGLKKFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H9G302</accession>
    <name>H9G302_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F42G4.5</name>
        <name evidence="2 4" type="ORF">F42G4.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCG28063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254367.1">
        <property type="nucleotide sequence ID" value="NM_001267438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G302"/>
    <dbReference type="GeneID" id="185674"/>
    <dbReference type="AGR" id="WB:WBGene00009642"/>
    <dbReference type="CTD" id="185674"/>
    <dbReference type="WormBase" id="F42G4.5c">
        <property type="protein sequence ID" value="CE47157"/>
        <property type="gene ID" value="WBGene00009642"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090440_0_0_1"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009642">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G302">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F42G4.5c"/>
        </source>
    </evidence>
    <sequence length="191" mass="21609" checksum="D424A3514B9D6B42" modified="2012-05-16" version="1">MRNCSTEIQALTLCEKQKLINFFKPEGDASGIIENNAFKAFNCSNLSSDLLKEDGSELLEQLWLKLNSLVIPSLQSMCFPLIEIDTSFDVQTLILTAFRDRVLAKLLQDADREFPQLKSILLTILVETEDIPTSLRTKIDICLGKSPSTSKPRYQKKIRSKTDSCLSSKRKSVSWMDDMQDNSRKSSTFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>I7K4J6</accession>
    <name>I7K4J6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">fbn-1</name>
        <name evidence="9" type="ORF">CELE_ZK783.1</name>
        <name evidence="11" type="ORF">ZK783.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCJ09409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263718.1">
        <property type="nucleotide sequence ID" value="NM_001276789.4"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="I7K4J6"/>
    <dbReference type="GeneID" id="176076"/>
    <dbReference type="AGR" id="WB:WBGene00022816"/>
    <dbReference type="CTD" id="176076"/>
    <dbReference type="WormBase" id="ZK783.1j">
        <property type="protein sequence ID" value="CE47737"/>
        <property type="gene ID" value="WBGene00022816"/>
        <property type="gene designation" value="fbn-1"/>
    </dbReference>
    <dbReference type="OMA" id="THECHEN"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022816">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="I7K4J6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000555">
        <property type="entry name" value="Dumpy, isoform I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
        <property type="entry name" value="UROMODULIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003711520" evidence="7">
        <location>
            <begin position="27"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="344"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1431"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1473"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1565"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1606"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1699"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1838"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1879"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="669"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1929"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="785"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="875"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="897"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="938"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="960"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="988"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1095"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1122"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1143"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1193"/>
            <end position="1205"/>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2003" name="Science" volume="301" first="1387" last="1391">
            <title>Autophagy genes are essential for dauer development and life-span extension in C. elegans.</title>
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                <person name="Melendez A."/>
                <person name="Talloczy Z."/>
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                <person name="Levine B."/>
            </authorList>
            <dbReference type="PubMed" id="12958363"/>
            <dbReference type="DOI" id="10.1126/science.1087782"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2009" name="Cell" volume="136" first="308" last="321">
            <title>SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans.</title>
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                <person name="Zhang Y."/>
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                <person name="Yang P."/>
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                <person name="Li Z."/>
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            </authorList>
            <dbReference type="PubMed" id="19167332"/>
            <dbReference type="DOI" id="10.1016/j.cell.2008.12.022"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2011" name="Autophagy" volume="7" first="386" last="400">
            <title>The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans.</title>
            <authorList>
                <person name="Ruck A."/>
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                <person name="Garces K.T."/>
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                <person name="Hall D.H."/>
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            </authorList>
            <dbReference type="PubMed" id="21183797"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2011" name="Dev. Cell" volume="21" first="343" last="357">
            <title>The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.</title>
            <authorList>
                <person name="Lu Q."/>
                <person name="Yang P."/>
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                <person name="Guo B."/>
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            </authorList>
            <dbReference type="PubMed" id="21802374"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2011.06.024"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF 228-ARG-ARG-229</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2012" name="J. Cell Biol." volume="197" first="27" last="35">
            <title>Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell.</title>
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                <person name="Li W."/>
                <person name="Zou W."/>
                <person name="Yang Y."/>
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            </authorList>
            <dbReference type="PubMed" id="22451698"/>
            <dbReference type="DOI" id="10.1083/jcb.201111053"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TOPOLOGY</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF 228-ARG-ARG-229</scope>
    </reference>
    <reference evidence="1" key="7">
        <citation type="journal article" date="2014" name="EMBO Rep." volume="15" first="973" last="981">
            <title>PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.</title>
            <authorList>
                <person name="Wu Y."/>
                <person name="Cheng S."/>
                <person name="Zhao H."/>
                <person name="Zou W."/>
                <person name="Yoshina S."/>
                <person name="Mitani S."/>
                <person name="Zhang H."/>
                <person name="Wang X."/>
            </authorList>
            <dbReference type="PubMed" id="25124690"/>
            <dbReference type="DOI" id="10.15252/embr.201438618"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="8">
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            <title>HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.</title>
            <authorList>
                <person name="Chen H.D."/>
                <person name="Kao C.Y."/>
                <person name="Liu B.Y."/>
                <person name="Huang S.W."/>
                <person name="Kuo C.J."/>
                <person name="Ruan J.W."/>
                <person name="Lin Y.H."/>
                <person name="Huang C.R."/>
                <person name="Chen Y.H."/>
                <person name="Wang H.D."/>
                <person name="Aroian R.V."/>
                <person name="Chen C.S."/>
            </authorList>
            <dbReference type="PubMed" id="27875098"/>
            <dbReference type="DOI" id="10.1080/15548627.2016.1256933"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="9">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="905" last="913">
            <title>A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development.</title>
            <authorList>
                <person name="Ames K."/>
                <person name="Da Cunha D.S."/>
                <person name="Gonzalez B."/>
                <person name="Konta M."/>
                <person name="Lin F."/>
                <person name="Shechter G."/>
                <person name="Starikov L."/>
                <person name="Wong S."/>
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                <person name="Melendez A."/>
            </authorList>
            <dbReference type="PubMed" id="28285998"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.02.015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="10">
        <citation type="journal article" date="2017" name="PLoS Genet." volume="13" first="E1006764" last="E1006764">
            <title>The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan.</title>
            <authorList>
                <person name="Minnerly J."/>
                <person name="Zhang J."/>
                <person name="Parker T."/>
                <person name="Kaul T."/>
                <person name="Jia K."/>
            </authorList>
            <dbReference type="PubMed" id="28557996"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006764"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="1" key="11">
        <citation type="journal article" date="2018" name="Am. J. Physiol." volume="2018" first="C0" last="C0">
            <title>Non-selective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hibshman J.D."/>
                <person name="Leuthner T.C."/>
                <person name="Shoben C."/>
                <person name="Mello D.F."/>
                <person name="Sherwood D.R."/>
                <person name="Meyer J.N."/>
                <person name="Baugh L.R."/>
            </authorList>
            <dbReference type="PubMed" id="30133321"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00109.2018"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
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        <event type="alternative splicing"/>
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            <id>O16466-2</id>
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        <isoform>
            <id>O16466-1</id>
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    <evidence type="ECO:0000312" key="2">
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    <evidence type="ECO:0000312" key="3">
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            <dbReference type="WormBase" id="F41E6.13a"/>
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    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F41E6.13b"/>
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    <accession>O62061</accession>
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            <taxon>Peloderinae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
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        <property type="entry name" value="T19339"/>
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    <evidence type="ECO:0000313" key="3">
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
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    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="GeneID" id="182684"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NeuroPeptide Receptor family"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="44"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAB03888.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="C16D6.2a"/>
        </source>
    </evidence>
    <sequence length="468" mass="52773" checksum="2A0F72C78EE353D5" modified="2004-11-23" version="2">MNGSDCLNLNSELWLYREDLSSRWYIMLVFAFLYLIIIAAGIIGNSCVILAITRNKSLQTVPNLFILSLSCSDIVVCCTSATITPITAFKKEWIFGEALCRIAPFIAGISLCFSTFTLTAISIDRYILIRFPMRKPITHYQAVGVIAIICAFAATITSPIMFKQKLGEFENFCGQYCTENWGANESQRKIYGAALMFLQLVIPLTIIIISYTAISLKIGQSMILKGAKKQKTDNWEMELSDQQRIAVKRRQRTNRMLIGMVVAFACSWIWSVTFNILRDYEYLPELIKTQEYIFGIATHCIAMTSTVWNPLLYAVLNLQLRAAFIDLMPHWLRRHLNLEGDNSSPLLNHPTMTITNKYGSTATKTVKATYINTSNGQPYVSTSLVGKVQPEAPSFKFNGSGRKKSAMMRILVQKRNAEEEEQLITKESPSPPEIQMDTLCAASIIPRRKSAQPRSTNEKVVLPRKASF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-05-01" modified="2026-01-28" version="205" xmlns="https://uniprot.org/uniprot">
    <accession>P21137-10</accession>
    <name>KAPC1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform j of cAMP-dependent protein kinase catalytic subunit</fullName>
            <shortName>PKA C</shortName>
            <ecNumber evidence="2">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">kin-1</name>
        <name type="ORF">ZK909.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Biol. Chem." volume="265" first="6896" last="6907">
            <title>Cloning, characterization, and expression of the gene for the catalytic subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. Identification of highly conserved and unique isoforms generated by alternative splicing.</title>
            <authorList>
                <person name="Gross R.E."/>
                <person name="Bagchi S."/>
                <person name="Lu X."/>
                <person name="Rubin C.S."/>
            </authorList>
            <dbReference type="PubMed" id="2324104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND B)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Biochem. Biophys. Res. Commun." volume="238" first="523" last="527">
            <title>N-Myristoylation of the catalytic subunit of cAMP-dependent protein kinase in the free-living nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Aspbury R.A."/>
                <person name="Fisher M.J."/>
                <person name="Rees H.H."/>
                <person name="Clegg R.A."/>
            </authorList>
            <dbReference type="PubMed" id="9299544"/>
            <dbReference type="DOI" id="10.1006/bbrc.1997.7165"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>MYRISTOYLATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1999" name="Biochem. J." volume="339" first="209" last="216">
            <title>Organization and alternative splicing of the Caenorhabditis elegans cyclic AMP-dependent protein kinase (PK-A) catalytic subunit gene (kin-1).</title>
            <authorList>
                <person name="Tabish M."/>
                <person name="Clegg R.A."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="10085246"/>
            <dbReference type="DOI" id="10.1042/0264-6021:3390209"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 1-73</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Cell. Signal." volume="18" first="2230" last="2237">
            <title>Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.</title>
            <authorList>
                <person name="Bowen L.C."/>
                <person name="Bicknell A.V."/>
                <person name="Tabish M."/>
                <person name="Clegg R.A."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="16806821"/>
            <dbReference type="DOI" id="10.1016/j.cellsig.2006.05.002"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Gene" volume="408" first="157" last="163">
            <title>siRNA-mediated knockdown of a splice variant of the PK-A catalytic subunit gene causes adult-onset paralysis in C. elegans.</title>
            <authorList>
                <person name="Murray P."/>
                <person name="Clegg R.A."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="18077108"/>
            <dbReference type="DOI" id="10.1016/j.gene.2007.10.034"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CHARACTERIZATION OF ISOFORMS A; B; F AND K</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Arch. Biochem. Biophys." volume="519" first="38" last="45">
            <title>Characterisation of the N'1 isoform of the cyclic AMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.</title>
            <authorList>
                <person name="Clegg R.A."/>
                <person name="Bowen L.C."/>
                <person name="Bicknell A.V."/>
                <person name="Tabish M."/>
                <person name="Prescott M.C."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="22286028"/>
            <dbReference type="DOI" id="10.1016/j.abb.2012.01.008"/>
        </citation>
        <scope>MYRISTOYLATION AT GLY-2 (ISOFORMS H AND J)</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2012" name="Genetics" volume="192" first="905" last="928">
            <title>SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation to the sperm-to-oocyte switch and gamete maintenance in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kim S."/>
                <person name="Govindan J.A."/>
                <person name="Tu Z.J."/>
                <person name="Greenstein D."/>
            </authorList>
            <dbReference type="PubMed" id="22887816"/>
            <dbReference type="DOI" id="10.1534/genetics.112.143271"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003831" last="E1003831">
            <title>PKA controls calcium influx into motor neurons during a rhythmic behavior.</title>
            <authorList>
                <person name="Wang H."/>
                <person name="Sieburth D."/>
            </authorList>
            <dbReference type="PubMed" id="24086161"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003831"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>MUTAGENESIS OF HIS-125 AND TRP-234</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P21137-11</id>
            <name>k</name>
            <sequence type="described" ref="VSP_004752"/>
        </isoform>
        <isoform>
            <id>P21137-10</id>
            <name>j</name>
            <sequence type="described" ref="VSP_004753"/>
        </isoform>
        <isoform>
            <id>P21137-12</id>
            <name>l</name>
            <sequence type="described" ref="VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-5</id>
            <name>d</name>
            <sequence type="described" ref="VSP_004750"/>
        </isoform>
        <isoform>
            <id>P21137-2</id>
            <name>a</name>
            <name>Major</name>
            <sequence type="described" ref="VSP_004751 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_004758 VSP_004752"/>
        </isoform>
        <isoform>
            <id>P21137-1</id>
            <name>e</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P21137-8</id>
            <name>h</name>
            <sequence type="described" ref="VSP_004753 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-9</id>
            <name>i</name>
            <sequence type="described" ref="VSP_004754"/>
        </isoform>
        <isoform>
            <id>P21137-7</id>
            <name>g</name>
            <sequence type="described" ref="VSP_004754 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-13</id>
            <name>m</name>
            <sequence type="described" ref="VSP_004750 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-4</id>
            <name>c</name>
            <sequence type="described" ref="VSP_004757 VSP_004756"/>
        </isoform>
        <isoform>
            <id>P21137-3</id>
            <name>b</name>
            <name>Minor</name>
            <sequence type="described" ref="VSP_004751"/>
        </isoform>
        <text>Experimental confirmation may be lacking for some isoforms.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="2"/>
    <dbReference type="RefSeq" id="NP_001367024.1">
        <property type="nucleotide sequence ID" value="NM_001381270.1"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK909.2j">
        <property type="protein sequence ID" value="CE31762"/>
        <property type="gene ID" value="WBGene00002189"/>
        <property type="gene designation" value="kin-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <feature type="initiator methionine" description="Removed" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-myristoyl glycine" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="22286028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="9299544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="397" mass="44885" checksum="8F4257A19C3CC0B6" modified="2003-02-12" version="3">MGNAASGGSSGGGGSARRGNGGGNNGSDYNNAMVFSNGRLAAAETIKEFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYGNLKNGVADIKNHKWFGSTDWIAIYQKKITPPSFSKGESNGRLFEALYPRVDGPADTRHFVEEVQEPTEFVIAATPQLEELFVEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-05-01" modified="2026-01-28" version="205" xmlns="https://uniprot.org/uniprot">
    <accession>P21137-11</accession>
    <name>KAPC1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform k of cAMP-dependent protein kinase catalytic subunit</fullName>
            <shortName>PKA C</shortName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">kin-1</name>
        <name type="ORF">ZK909.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Biol. Chem." volume="265" first="6896" last="6907">
            <title>Cloning, characterization, and expression of the gene for the catalytic subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. Identification of highly conserved and unique isoforms generated by alternative splicing.</title>
            <authorList>
                <person name="Gross R.E."/>
                <person name="Bagchi S."/>
                <person name="Lu X."/>
                <person name="Rubin C.S."/>
            </authorList>
            <dbReference type="PubMed" id="2324104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND B)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Biochem. Biophys. Res. Commun." volume="238" first="523" last="527">
            <title>N-Myristoylation of the catalytic subunit of cAMP-dependent protein kinase in the free-living nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Aspbury R.A."/>
                <person name="Fisher M.J."/>
                <person name="Rees H.H."/>
                <person name="Clegg R.A."/>
            </authorList>
            <dbReference type="PubMed" id="9299544"/>
            <dbReference type="DOI" id="10.1006/bbrc.1997.7165"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>MYRISTOYLATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1999" name="Biochem. J." volume="339" first="209" last="216">
            <title>Organization and alternative splicing of the Caenorhabditis elegans cyclic AMP-dependent protein kinase (PK-A) catalytic subunit gene (kin-1).</title>
            <authorList>
                <person name="Tabish M."/>
                <person name="Clegg R.A."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="10085246"/>
            <dbReference type="DOI" id="10.1042/0264-6021:3390209"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 1-73</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Cell. Signal." volume="18" first="2230" last="2237">
            <title>Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.</title>
            <authorList>
                <person name="Bowen L.C."/>
                <person name="Bicknell A.V."/>
                <person name="Tabish M."/>
                <person name="Clegg R.A."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="16806821"/>
            <dbReference type="DOI" id="10.1016/j.cellsig.2006.05.002"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Gene" volume="408" first="157" last="163">
            <title>siRNA-mediated knockdown of a splice variant of the PK-A catalytic subunit gene causes adult-onset paralysis in C. elegans.</title>
            <authorList>
                <person name="Murray P."/>
                <person name="Clegg R.A."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="18077108"/>
            <dbReference type="DOI" id="10.1016/j.gene.2007.10.034"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CHARACTERIZATION OF ISOFORMS A; B; F AND K</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Arch. Biochem. Biophys." volume="519" first="38" last="45">
            <title>Characterisation of the N'1 isoform of the cyclic AMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.</title>
            <authorList>
                <person name="Clegg R.A."/>
                <person name="Bowen L.C."/>
                <person name="Bicknell A.V."/>
                <person name="Tabish M."/>
                <person name="Prescott M.C."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="22286028"/>
            <dbReference type="DOI" id="10.1016/j.abb.2012.01.008"/>
        </citation>
        <scope>MYRISTOYLATION AT GLY-2 (ISOFORMS H AND J)</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2012" name="Genetics" volume="192" first="905" last="928">
            <title>SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation to the sperm-to-oocyte switch and gamete maintenance in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kim S."/>
                <person name="Govindan J.A."/>
                <person name="Tu Z.J."/>
                <person name="Greenstein D."/>
            </authorList>
            <dbReference type="PubMed" id="22887816"/>
            <dbReference type="DOI" id="10.1534/genetics.112.143271"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003831" last="E1003831">
            <title>PKA controls calcium influx into motor neurons during a rhythmic behavior.</title>
            <authorList>
                <person name="Wang H."/>
                <person name="Sieburth D."/>
            </authorList>
            <dbReference type="PubMed" id="24086161"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003831"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>MUTAGENESIS OF HIS-125 AND TRP-234</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P21137-5</id>
            <name>d</name>
            <sequence type="described" ref="VSP_004750"/>
        </isoform>
        <isoform>
            <id>P21137-13</id>
            <name>m</name>
            <sequence type="described" ref="VSP_004758 VSP_004750"/>
        </isoform>
        <isoform>
            <id>P21137-4</id>
            <name>c</name>
            <sequence type="described" ref="VSP_004756 VSP_004757"/>
        </isoform>
        <isoform>
            <id>P21137-10</id>
            <name>j</name>
            <sequence type="described" ref="VSP_004753"/>
        </isoform>
        <isoform>
            <id>P21137-2</id>
            <name>a</name>
            <name>Major</name>
            <sequence type="described" ref="VSP_004751 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-11</id>
            <name>k</name>
            <sequence type="described" ref="VSP_004752"/>
        </isoform>
        <isoform>
            <id>P21137-7</id>
            <name>g</name>
            <sequence type="described" ref="VSP_004758 VSP_004754"/>
        </isoform>
        <isoform>
            <id>P21137-12</id>
            <name>l</name>
            <sequence type="described" ref="VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-1</id>
            <name>e</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P21137-3</id>
            <name>b</name>
            <name>Minor</name>
            <sequence type="described" ref="VSP_004751"/>
        </isoform>
        <isoform>
            <id>P21137-8</id>
            <name>h</name>
            <sequence type="described" ref="VSP_004758 VSP_004753"/>
        </isoform>
        <isoform>
            <id>P21137-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_004752 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-9</id>
            <name>i</name>
            <sequence type="described" ref="VSP_004754"/>
        </isoform>
        <text>Experimental confirmation may be lacking for some isoforms.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001367025.1">
        <property type="nucleotide sequence ID" value="NM_001381273.1"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK909.2k">
        <property type="protein sequence ID" value="CE31763"/>
        <property type="gene ID" value="WBGene00002189"/>
        <property type="gene designation" value="kin-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="9299544"/>
        </source>
    </evidence>
    <sequence length="386" mass="44619" checksum="87FEAE1CC31AD9FB" modified="2003-02-12" version="3">MLSSSFFRGSMKERKNEALKNHKSKYISGGYLETVKEFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYGNLKNGVADIKNHKWFGSTDWIAIYQKKITPPSFSKGESNGRLFEALYPRVDGPADTRHFVEEVQEPTEFVIAATPQLEELFVEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-05-01" modified="2026-01-28" version="205" xmlns="https://uniprot.org/uniprot">
    <accession>P21137-12</accession>
    <name>KAPC1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform l of cAMP-dependent protein kinase catalytic subunit</fullName>
            <shortName>PKA C</shortName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">kin-1</name>
        <name type="ORF">ZK909.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Biol. Chem." volume="265" first="6896" last="6907">
            <title>Cloning, characterization, and expression of the gene for the catalytic subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. Identification of highly conserved and unique isoforms generated by alternative splicing.</title>
            <authorList>
                <person name="Gross R.E."/>
                <person name="Bagchi S."/>
                <person name="Lu X."/>
                <person name="Rubin C.S."/>
            </authorList>
            <dbReference type="PubMed" id="2324104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND B)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Biochem. Biophys. Res. Commun." volume="238" first="523" last="527">
            <title>N-Myristoylation of the catalytic subunit of cAMP-dependent protein kinase in the free-living nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Aspbury R.A."/>
                <person name="Fisher M.J."/>
                <person name="Rees H.H."/>
                <person name="Clegg R.A."/>
            </authorList>
            <dbReference type="PubMed" id="9299544"/>
            <dbReference type="DOI" id="10.1006/bbrc.1997.7165"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>MYRISTOYLATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1999" name="Biochem. J." volume="339" first="209" last="216">
            <title>Organization and alternative splicing of the Caenorhabditis elegans cyclic AMP-dependent protein kinase (PK-A) catalytic subunit gene (kin-1).</title>
            <authorList>
                <person name="Tabish M."/>
                <person name="Clegg R.A."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="10085246"/>
            <dbReference type="DOI" id="10.1042/0264-6021:3390209"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 1-73</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Cell. Signal." volume="18" first="2230" last="2237">
            <title>Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.</title>
            <authorList>
                <person name="Bowen L.C."/>
                <person name="Bicknell A.V."/>
                <person name="Tabish M."/>
                <person name="Clegg R.A."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="16806821"/>
            <dbReference type="DOI" id="10.1016/j.cellsig.2006.05.002"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Gene" volume="408" first="157" last="163">
            <title>siRNA-mediated knockdown of a splice variant of the PK-A catalytic subunit gene causes adult-onset paralysis in C. elegans.</title>
            <authorList>
                <person name="Murray P."/>
                <person name="Clegg R.A."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="18077108"/>
            <dbReference type="DOI" id="10.1016/j.gene.2007.10.034"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CHARACTERIZATION OF ISOFORMS A; B; F AND K</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Arch. Biochem. Biophys." volume="519" first="38" last="45">
            <title>Characterisation of the N'1 isoform of the cyclic AMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.</title>
            <authorList>
                <person name="Clegg R.A."/>
                <person name="Bowen L.C."/>
                <person name="Bicknell A.V."/>
                <person name="Tabish M."/>
                <person name="Prescott M.C."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="22286028"/>
            <dbReference type="DOI" id="10.1016/j.abb.2012.01.008"/>
        </citation>
        <scope>MYRISTOYLATION AT GLY-2 (ISOFORMS H AND J)</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2012" name="Genetics" volume="192" first="905" last="928">
            <title>SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation to the sperm-to-oocyte switch and gamete maintenance in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kim S."/>
                <person name="Govindan J.A."/>
                <person name="Tu Z.J."/>
                <person name="Greenstein D."/>
            </authorList>
            <dbReference type="PubMed" id="22887816"/>
            <dbReference type="DOI" id="10.1534/genetics.112.143271"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003831" last="E1003831">
            <title>PKA controls calcium influx into motor neurons during a rhythmic behavior.</title>
            <authorList>
                <person name="Wang H."/>
                <person name="Sieburth D."/>
            </authorList>
            <dbReference type="PubMed" id="24086161"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003831"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>MUTAGENESIS OF HIS-125 AND TRP-234</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P21137-9</id>
            <name>i</name>
            <sequence type="described" ref="VSP_004754"/>
        </isoform>
        <isoform>
            <id>P21137-1</id>
            <name>e</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P21137-5</id>
            <name>d</name>
            <sequence type="described" ref="VSP_004750"/>
        </isoform>
        <isoform>
            <id>P21137-7</id>
            <name>g</name>
            <sequence type="described" ref="VSP_004754 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-11</id>
            <name>k</name>
            <sequence type="described" ref="VSP_004752"/>
        </isoform>
        <isoform>
            <id>P21137-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_004752 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-10</id>
            <name>j</name>
            <sequence type="described" ref="VSP_004753"/>
        </isoform>
        <isoform>
            <id>P21137-8</id>
            <name>h</name>
            <sequence type="described" ref="VSP_004753 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-2</id>
            <name>a</name>
            <name>Major</name>
            <sequence type="described" ref="VSP_004758 VSP_004751"/>
        </isoform>
        <isoform>
            <id>P21137-13</id>
            <name>m</name>
            <sequence type="described" ref="VSP_004750 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-12</id>
            <name>l</name>
            <sequence type="described" ref="VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-3</id>
            <name>b</name>
            <name>Minor</name>
            <sequence type="described" ref="VSP_004751"/>
        </isoform>
        <isoform>
            <id>P21137-4</id>
            <name>c</name>
            <sequence type="described" ref="VSP_004757 VSP_004756"/>
        </isoform>
        <text>Experimental confirmation may be lacking for some isoforms.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="RefSeq" id="NP_740960.1">
        <property type="nucleotide sequence ID" value="NM_170964.6"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK909.2l">
        <property type="protein sequence ID" value="CE31764"/>
        <property type="gene ID" value="WBGene00002189"/>
        <property type="gene designation" value="kin-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="9299544"/>
        </source>
    </evidence>
    <sequence length="388" mass="44515" checksum="9376F56725E780B5" modified="2003-02-12" version="3">MPTRLDIVGNLQFSSSTDNGDEDQEADVTACFVLPSPSSFSKLSILDDPVEDFKEFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYGNLKNGVADIKNHKWFGSTDWIAIYQKKIEAPFLPKCRGPGDASNFDDYEEEPLRISGTEKCAKEFAEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-05-01" modified="2026-01-28" version="205" xmlns="https://uniprot.org/uniprot">
    <accession>P21137-13</accession>
    <name>KAPC1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform m of cAMP-dependent protein kinase catalytic subunit</fullName>
            <shortName>PKA C</shortName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">kin-1</name>
        <name type="ORF">ZK909.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Biol. Chem." volume="265" first="6896" last="6907">
            <title>Cloning, characterization, and expression of the gene for the catalytic subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. Identification of highly conserved and unique isoforms generated by alternative splicing.</title>
            <authorList>
                <person name="Gross R.E."/>
                <person name="Bagchi S."/>
                <person name="Lu X."/>
                <person name="Rubin C.S."/>
            </authorList>
            <dbReference type="PubMed" id="2324104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND B)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Biochem. Biophys. Res. Commun." volume="238" first="523" last="527">
            <title>N-Myristoylation of the catalytic subunit of cAMP-dependent protein kinase in the free-living nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Aspbury R.A."/>
                <person name="Fisher M.J."/>
                <person name="Rees H.H."/>
                <person name="Clegg R.A."/>
            </authorList>
            <dbReference type="PubMed" id="9299544"/>
            <dbReference type="DOI" id="10.1006/bbrc.1997.7165"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>MYRISTOYLATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1999" name="Biochem. J." volume="339" first="209" last="216">
            <title>Organization and alternative splicing of the Caenorhabditis elegans cyclic AMP-dependent protein kinase (PK-A) catalytic subunit gene (kin-1).</title>
            <authorList>
                <person name="Tabish M."/>
                <person name="Clegg R.A."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="10085246"/>
            <dbReference type="DOI" id="10.1042/0264-6021:3390209"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 1-73</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Cell. Signal." volume="18" first="2230" last="2237">
            <title>Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.</title>
            <authorList>
                <person name="Bowen L.C."/>
                <person name="Bicknell A.V."/>
                <person name="Tabish M."/>
                <person name="Clegg R.A."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="16806821"/>
            <dbReference type="DOI" id="10.1016/j.cellsig.2006.05.002"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Gene" volume="408" first="157" last="163">
            <title>siRNA-mediated knockdown of a splice variant of the PK-A catalytic subunit gene causes adult-onset paralysis in C. elegans.</title>
            <authorList>
                <person name="Murray P."/>
                <person name="Clegg R.A."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="18077108"/>
            <dbReference type="DOI" id="10.1016/j.gene.2007.10.034"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CHARACTERIZATION OF ISOFORMS A; B; F AND K</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Arch. Biochem. Biophys." volume="519" first="38" last="45">
            <title>Characterisation of the N'1 isoform of the cyclic AMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.</title>
            <authorList>
                <person name="Clegg R.A."/>
                <person name="Bowen L.C."/>
                <person name="Bicknell A.V."/>
                <person name="Tabish M."/>
                <person name="Prescott M.C."/>
                <person name="Rees H.H."/>
                <person name="Fisher M.J."/>
            </authorList>
            <dbReference type="PubMed" id="22286028"/>
            <dbReference type="DOI" id="10.1016/j.abb.2012.01.008"/>
        </citation>
        <scope>MYRISTOYLATION AT GLY-2 (ISOFORMS H AND J)</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2012" name="Genetics" volume="192" first="905" last="928">
            <title>SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation to the sperm-to-oocyte switch and gamete maintenance in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kim S."/>
                <person name="Govindan J.A."/>
                <person name="Tu Z.J."/>
                <person name="Greenstein D."/>
            </authorList>
            <dbReference type="PubMed" id="22887816"/>
            <dbReference type="DOI" id="10.1534/genetics.112.143271"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003831" last="E1003831">
            <title>PKA controls calcium influx into motor neurons during a rhythmic behavior.</title>
            <authorList>
                <person name="Wang H."/>
                <person name="Sieburth D."/>
            </authorList>
            <dbReference type="PubMed" id="24086161"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003831"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>MUTAGENESIS OF HIS-125 AND TRP-234</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P21137-12</id>
            <name>l</name>
            <sequence type="described" ref="VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-7</id>
            <name>g</name>
            <sequence type="described" ref="VSP_004758 VSP_004754"/>
        </isoform>
        <isoform>
            <id>P21137-13</id>
            <name>m</name>
            <sequence type="described" ref="VSP_004750 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-10</id>
            <name>j</name>
            <sequence type="described" ref="VSP_004753"/>
        </isoform>
        <isoform>
            <id>P21137-4</id>
            <name>c</name>
            <sequence type="described" ref="VSP_004756 VSP_004757"/>
        </isoform>
        <isoform>
            <id>P21137-8</id>
            <name>h</name>
            <sequence type="described" ref="VSP_004753 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-1</id>
            <name>e</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P21137-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_004752 VSP_004758"/>
        </isoform>
        <isoform>
            <id>P21137-11</id>
            <name>k</name>
            <sequence type="described" ref="VSP_004752"/>
        </isoform>
        <isoform>
            <id>P21137-9</id>
            <name>i</name>
            <sequence type="described" ref="VSP_004754"/>
        </isoform>
        <isoform>
            <id>P21137-2</id>
            <name>a</name>
            <name>Major</name>
            <sequence type="described" ref="VSP_004758 VSP_004751"/>
        </isoform>
        <isoform>
            <id>P21137-3</id>
            <name>b</name>
            <name>Minor</name>
            <sequence type="described" ref="VSP_004751"/>
        </isoform>
        <isoform>
            <id>P21137-5</id>
            <name>d</name>
            <sequence type="described" ref="VSP_004750"/>
        </isoform>
        <text>Experimental confirmation may be lacking for some isoforms.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="RefSeq" id="NP_740962.1">
        <property type="nucleotide sequence ID" value="NM_170966.3"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK909.2m">
        <property type="protein sequence ID" value="CE31765"/>
        <property type="gene ID" value="WBGene00002189"/>
        <property type="gene designation" value="kin-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="9299544"/>
        </source>
    </evidence>
    <sequence length="349" mass="40381" checksum="C486DFDB5F4F033A" modified="2003-02-12" version="3">MSSSSNKKVQVKFFKEFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYGNLKNGVADIKNHKWFGSTDWIAIYQKKIEAPFLPKCRGPGDASNFDDYEEEPLRISGTEKCAKEFAEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>P34675-2</accession>
    <name>YO25_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Uncharacterized protein ZK688.5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">ZK688.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34675-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_017897"/>
        </isoform>
        <isoform>
            <id>P34675-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="WormBase" id="ZK688.5b">
        <property type="protein sequence ID" value="CE33264"/>
        <property type="gene ID" value="WBGene00022800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="1595" mass="179757" checksum="D8FA803F363273E2" modified="2002-06-20" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q09237-2</accession>
    <name>GYF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of GYF domain-containing protein gyf-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gyf-1</name>
        <name evidence="5" type="ORF">C18H9.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09237-3</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_060468"/>
        </isoform>
        <isoform>
            <id>Q09237-5</id>
            <name evidence="6">e</name>
            <sequence type="described" ref="VSP_060466"/>
        </isoform>
        <isoform>
            <id>Q09237-4</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_060467"/>
        </isoform>
        <isoform>
            <id>Q09237-1</id>
            <name evidence="5">d</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09237-2</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_060467 VSP_060468"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_495360.2">
        <property type="nucleotide sequence ID" value="NM_062959.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C18H9.3a">
        <property type="protein sequence ID" value="CE47928"/>
        <property type="gene ID" value="WBGene00016002"/>
        <property type="gene designation" value="gyf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C18H9.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C18H9.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C18H9.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C18H9.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C18H9.3e"/>
        </source>
    </evidence>
    <sequence length="1035" mass="113487" checksum="F205DFA488CCB6F2" modified="2020-02-26" version="4"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q09237-3</accession>
    <name>GYF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of GYF domain-containing protein gyf-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gyf-1</name>
        <name evidence="5" type="ORF">C18H9.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09237-4</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_060467"/>
        </isoform>
        <isoform>
            <id>Q09237-1</id>
            <name evidence="5">d</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09237-2</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_060467 VSP_060468"/>
        </isoform>
        <isoform>
            <id>Q09237-3</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_060468"/>
        </isoform>
        <isoform>
            <id>Q09237-5</id>
            <name evidence="6">e</name>
            <sequence type="described" ref="VSP_060466"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001343744.1">
        <property type="nucleotide sequence ID" value="NM_001356865.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C18H9.3b">
        <property type="protein sequence ID" value="CE52358"/>
        <property type="gene ID" value="WBGene00016002"/>
        <property type="gene designation" value="gyf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C18H9.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C18H9.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C18H9.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C18H9.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C18H9.3e"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113845" checksum="40FE22164031F750" modified="2020-02-26" version="4"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q09237-4</accession>
    <name>GYF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of GYF domain-containing protein gyf-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gyf-1</name>
        <name evidence="5" type="ORF">C18H9.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09237-2</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_060468 VSP_060467"/>
        </isoform>
        <isoform>
            <id>Q09237-3</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_060468"/>
        </isoform>
        <isoform>
            <id>Q09237-1</id>
            <name evidence="5">d</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09237-4</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_060467"/>
        </isoform>
        <isoform>
            <id>Q09237-5</id>
            <name evidence="6">e</name>
            <sequence type="described" ref="VSP_060466"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001343745.1">
        <property type="nucleotide sequence ID" value="NM_001356866.2"/>
    </dbReference>
    <dbReference type="WormBase" id="C18H9.3c">
        <property type="protein sequence ID" value="CE52279"/>
        <property type="gene ID" value="WBGene00016002"/>
        <property type="gene designation" value="gyf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C18H9.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C18H9.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C18H9.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C18H9.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C18H9.3e"/>
        </source>
    </evidence>
    <sequence length="1103" mass="120801" checksum="FA326B234E8EC3DA" modified="2020-02-26" version="4"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q09237-5</accession>
    <name>GYF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform e of GYF domain-containing protein gyf-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gyf-1</name>
        <name evidence="5" type="ORF">C18H9.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09237-3</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_060468"/>
        </isoform>
        <isoform>
            <id>Q09237-2</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_060468 VSP_060467"/>
        </isoform>
        <isoform>
            <id>Q09237-4</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_060467"/>
        </isoform>
        <isoform>
            <id>Q09237-1</id>
            <name evidence="5">d</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09237-5</id>
            <name evidence="6">e</name>
            <sequence type="described" ref="VSP_060466"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001343747.1">
        <property type="nucleotide sequence ID" value="NM_001356867.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C18H9.3e">
        <property type="protein sequence ID" value="CE43752"/>
        <property type="gene ID" value="WBGene00016002"/>
        <property type="gene designation" value="gyf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C18H9.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C18H9.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C18H9.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C18H9.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C18H9.3e"/>
        </source>
    </evidence>
    <sequence length="107" mass="11378" checksum="842B36B2B4C6ACDA" modified="2020-02-26" version="4">MSYLDESKTVKEFVREFIKRRIAMRAAGGRPDADDLTSARTAAAAPSDSNSGSNSNSGNGQGKKKKKTQKQVLDGNILGFRGTAAADRLNKGEIDAVPSAPVNPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>Q18351</accession>
    <name>Q18351_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">kvs-2</name>
        <name evidence="17" type="ORF">C32C4.1</name>
        <name evidence="15" type="ORF">CELE_C32C4.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA98109.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T19635">
        <property type="entry name" value="T19635"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_505725.3">
        <property type="nucleotide sequence ID" value="NM_073324.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18351"/>
    <dbReference type="SMR" id="Q18351"/>
    <dbReference type="GeneID" id="183120"/>
    <dbReference type="UCSC" id="C32C4.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007862"/>
    <dbReference type="CTD" id="183120"/>
    <dbReference type="WormBase" id="C32C4.1a">
        <property type="protein sequence ID" value="CE37877"/>
        <property type="gene ID" value="WBGene00007862"/>
        <property type="gene designation" value="kvs-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007862">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18351">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000088">
        <property type="entry name" value="Protein CBG09661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000176">
        <property type="entry name" value="Protein CBG09661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF121">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="63"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAA98109.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C32C4.1a"/>
        </source>
    </evidence>
    <sequence length="529" mass="60125" checksum="D48BA24DB1E33559" modified="2005-03-01" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="163" xmlns="https://uniprot.org/uniprot">
    <accession>Q18352</accession>
    <name>Q18352_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">aqp-6</name>
        <name evidence="11" type="ORF">C32C4.2</name>
        <name evidence="9" type="ORF">CELE_C32C4.2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA98110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T19636">
        <property type="entry name" value="T19636"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256248.1">
        <property type="nucleotide sequence ID" value="NM_001269319.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18352"/>
    <dbReference type="SMR" id="Q18352"/>
    <dbReference type="GeneID" id="183121"/>
    <dbReference type="UCSC" id="C32C4.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000174"/>
    <dbReference type="CTD" id="183121"/>
    <dbReference type="WormBase" id="C32C4.2a">
        <property type="protein sequence ID" value="CE05345"/>
        <property type="gene ID" value="WBGene00000174"/>
        <property type="gene designation" value="aqp-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_3_3_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="PhylomeDB" id="Q18352"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000174">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18352">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006833">
        <property type="term" value="P:water transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000019">
        <property type="entry name" value="AQuaPorin or aquaglyceroporin related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
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        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF284">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAA98110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C32C4.2a"/>
        </source>
    </evidence>
    <sequence length="244" mass="26390" checksum="EAD332A96650E8E4" modified="1996-11-01" version="1">MVEDEKDYTIYSKCAAEFIAVLLFVYIGSMQAAGVFLHDGVLHAAFAHGVAIFVLAATFGGVSGAHINPAVTFGIALVGRISPIHAVCYVVSQLLGSVFGALLVRISLPYKMYNVISAGATLCGKGYNWQEGLTAEIVTTYILVQTVLLCAVDTDKNRLAPLAIGFSLIIEILAAGAISGASMNPARSFGPNIMGQVFLKPEHLDAQYMYWNYHWIYYIGPIIGAFIAAGVYRMFFARDYRVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q18353</accession>
    <name>Q18353_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">mdss-1</name>
        <name evidence="6" type="ORF">C32C4.3</name>
        <name evidence="4" type="ORF">CELE_C32C4.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA98111.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T19637">
        <property type="entry name" value="T19637"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256242.1">
        <property type="nucleotide sequence ID" value="NM_001269313.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18353"/>
    <dbReference type="GeneID" id="183122"/>
    <dbReference type="UCSC" id="C32C4.3">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007863"/>
    <dbReference type="CTD" id="183122"/>
    <dbReference type="WormBase" id="C32C4.3a">
        <property type="protein sequence ID" value="CE37878"/>
        <property type="gene ID" value="WBGene00007863"/>
        <property type="gene designation" value="mdss-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843550at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007863">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18353">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004186709" evidence="3">
        <location>
            <begin position="19"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA98111.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C32C4.3a"/>
        </source>
    </evidence>
    <sequence length="357" mass="40812" checksum="D1E10E894591991E" modified="2005-03-01" version="3">MWCFLFLLISYISLVSNAILNPCEVLDKTKTDLSFVTVLFINLEYTPFVAPKVAKNQSIQDIFESLNNQHFHLFKFNYLPQVIETFMKCYGRDSGLQIESLSFEKQLSVMQKCNLKTRGINQALLRGKVIRVFESLEFLTTCGPHQLDPLLLSISSESTALVRQKIGLCHHHDCKLLKLFGFDAIPFTTESLFYEKLETIVDSFASLSSAFLNISDGIEPKYMYFSSVPTSYTPIWPSLVAVFVVLIFFVMGLILCCCGLFMFGLVEEDFQKRNEENEWLEANRRREEYLINAHEDPIEIPNLHNQDNSRSSESDMLPHTAKSHNSMVSSTSSTAVVTDRTQMSETEPLIRPNPKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="166" xmlns="https://uniprot.org/uniprot">
    <accession>Q18361</accession>
    <name>Q18361_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">ugt-21</name>
        <name evidence="14" type="ORF">C33A12.6</name>
        <name evidence="12" type="ORF">CELE_C33A12.6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="11"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA92791.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_501680.2">
        <property type="nucleotide sequence ID" value="NM_069279.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18361"/>
    <dbReference type="SMR" id="Q18361"/>
    <dbReference type="CAZy" id="GT1">
        <property type="family name" value="Glycosyltransferase Family 1"/>
    </dbReference>
    <dbReference type="PaxDb" id="6239-C33A12.6"/>
    <dbReference type="PeptideAtlas" id="Q18361"/>
    <dbReference type="GeneID" id="183141"/>
    <dbReference type="UCSC" id="C33A12.6">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007885"/>
    <dbReference type="CTD" id="183141"/>
    <dbReference type="WormBase" id="C33A12.6a">
        <property type="protein sequence ID" value="CE43641"/>
        <property type="gene ID" value="WBGene00007885"/>
        <property type="gene designation" value="ugt-21"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012949_1_1_1"/>
    <dbReference type="OMA" id="NILYAKW"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="Q18361"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007885">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18361">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000380">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAA92791.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="C33A12.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q18361"/>
        </source>
    </evidence>
    <sequence length="534" mass="59853" checksum="54B4086FAC155F9A" modified="2009-05-26" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q19681</accession>
    <name>Q19681_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OTU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">otub-3</name>
        <name evidence="4" type="ORF">CELE_F21D5.2</name>
        <name evidence="6" type="ORF">F21D5.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA91033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21195">
        <property type="entry name" value="T21195"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255318.1">
        <property type="nucleotide sequence ID" value="NM_001268389.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19681"/>
    <dbReference type="SMR" id="Q19681"/>
    <dbReference type="PeptideAtlas" id="Q19681"/>
    <dbReference type="GeneID" id="177679"/>
    <dbReference type="KEGG" id="cel:CELE_F21D5.2"/>
    <dbReference type="UCSC" id="F21D5.2.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009007"/>
    <dbReference type="CTD" id="177679"/>
    <dbReference type="WormBase" id="F21D5.2a">
        <property type="protein sequence ID" value="CE03245"/>
        <property type="gene ID" value="WBGene00009007"/>
        <property type="gene designation" value="otub-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034963_0_0_1"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="PhylomeDB" id="Q19681"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009007">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q19681">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22761">
        <property type="entry name" value="OTU_OTUD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000030">
        <property type="entry name" value="OTUBain deubiquitylating protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049772">
        <property type="entry name" value="OTU_OTUD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="3">
        <location>
            <begin position="167"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA91033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F21D5.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q19681"/>
        </source>
    </evidence>
    <sequence length="309" mass="34704" checksum="2A15EC6CC12F18F3" modified="1996-11-01" version="1">MSSDGEQDEENPILARHRREKKELRGKILAKKKAAKCGNKQMQKEAGAECEKMEKEMDERHKKELEEAKKPEESEAVPAENPEASTLSPPSPNPEGSDNDGEGPSSSAFYKTVKISNKAAKKQDKKKKTADKMKAAEAADKEAGKNQLSDRQMEKAAVKEMLAEDHMKMIDIPADGDCMYNAISHQLQEEGIEISVRKLRKRCGTYMREHSEDFRPFIEDMANMDSDSSWATYLGGVENVAEIGGVWGGELELKACSMIFEKTIVVYKQYGGRHTIGEEYSSPKDRALRVVFLRHAYSLGEHYNSTCPY</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>Q19693</accession>
    <name>Q19693_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">glr-8</name>
        <name evidence="15" type="ORF">CELE_F22A3.3</name>
        <name evidence="17" type="ORF">F22A3.3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD64577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34233">
        <property type="entry name" value="T34233"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367505.1">
        <property type="nucleotide sequence ID" value="NM_001381010.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19693"/>
    <dbReference type="SMR" id="Q19693"/>
    <dbReference type="PaxDb" id="6239-F22A3.3"/>
    <dbReference type="GeneID" id="180924"/>
    <dbReference type="UCSC" id="F22A3.3">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001619"/>
    <dbReference type="CTD" id="180924"/>
    <dbReference type="WormBase" id="F22A3.3a">
        <property type="protein sequence ID" value="CE27990"/>
        <property type="gene ID" value="WBGene00001619"/>
        <property type="gene designation" value="glr-8"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_550104_0_0_1"/>
    <dbReference type="OMA" id="GGAIMEY"/>
    <dbReference type="OrthoDB" id="9997229at2759"/>
    <dbReference type="PhylomeDB" id="Q19693"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001619">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q19693">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00998">
        <property type="entry name" value="PBP2_iGluR_ligand_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000232">
        <property type="entry name" value="GLutamate Receptor family (AMPA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000292">
        <property type="entry name" value="GLutamate Receptor family (AMPA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD64577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="F22A3.3a"/>
        </source>
    </evidence>
    <sequence length="489" mass="54981" checksum="3AB9654CE0FA61BF" modified="2001-10-01" version="2">MKGRTLKMVVPAIEPPYVNYVNFSDAAVTDKGYGPGVVMEILKEIGKRLNLTYEILPALGSTWGEYLNGSWTGAFGQLVRGEVDLLAGGAIMEYDRSVIADLTYPFQFEPTGIMIRSPEKYEDDTLLIVTEPFSWEVWVITAAVILISGVIFLVMTNIIRKVYEEMTVTPFESIWVFFSIFVQQGLPEQPRSWSCRVLVALWWLASITLSATFTGSLVALFAVDKTNVPFQNIDQLVRLVKQGKFEIVMDENSFTRTEMIARSKLPVYRDLWHEMIVNHKVKYVNGIARGVAFVRANPGYALLGPMATLNFYAYSDCKVILFNDGILPVYLSIPLVKNSIYSPYFSTKIREMVERGFTQKWIADYRSYVAMQKINECNSTTIGPKSYLDLKRAQGAFWVFLGGAGLGLALFVGEFIFKFFREKMTKHTKTTTVPPEVATVSANVAENSTSLDIPDEVLPSAPLPSEDGNWSLRRRNILNLSLDLSNIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-05-16" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q1RPT9</accession>
    <name>Q1RPT9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Calx-beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24 26" type="primary">ncx-1</name>
        <name evidence="24" type="ORF">CELE_Y113G7A.4</name>
        <name evidence="26" type="ORF">Y113G7A.4</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAJ90511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041183.1">
        <property type="nucleotide sequence ID" value="NM_001047718.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1RPT9"/>
    <dbReference type="SMR" id="Q1RPT9"/>
    <dbReference type="GeneID" id="180318"/>
    <dbReference type="UCSC" id="Y113G7A.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003566"/>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
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        <citation type="journal article" date="2005" name="Glycobiology" volume="15" first="952" last="964">
            <title>Identification of the hydrophobic glycoproteins of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Fan X."/>
                <person name="She Y.-M."/>
                <person name="Bagshaw R.D."/>
                <person name="Callahan J.W."/>
                <person name="Schachter H."/>
                <person name="Mahuran D.J."/>
            </authorList>
            <dbReference type="PubMed" id="15888633"/>
            <dbReference type="DOI" id="10.1093/glycob/cwi075"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-142</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
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                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-163 AND ASN-176</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
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    <reference key="2">
        <citation type="journal article" date="2005" name="Glycobiology" volume="15" first="952" last="964">
            <title>Identification of the hydrophobic glycoproteins of Caenorhabditis elegans.</title>
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                <person name="Fan X."/>
                <person name="She Y.-M."/>
                <person name="Bagshaw R.D."/>
                <person name="Callahan J.W."/>
                <person name="Schachter H."/>
                <person name="Mahuran D.J."/>
            </authorList>
            <dbReference type="PubMed" id="15888633"/>
            <dbReference type="DOI" id="10.1093/glycob/cwi075"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-142</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
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                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-163 AND ASN-176</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
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        </isoform>
        <isoform>
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            <sequence type="described" ref="VSP_029775"/>
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    <accession>Q20664</accession>
    <name>Q20664_CAEEL</name>
    <protein>
        <recommendedName>
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        <lineage>
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            <taxon>Rhabditina</taxon>
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        </lineage>
    </organism>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">Bristol N2</strain>
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        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="3 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.78" evidence="4 11"/>
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        <property type="entry name" value="D89130"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="WBGene00018697"/>
        <property type="gene designation" value="bus-6"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TGNC">
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PtdIns-P2-Ptase"/>
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    <dbReference type="PANTHER" id="PTHR21014">
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        <location>
            <begin position="102"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001261"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365008"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD70811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F52E1.9a"/>
        </source>
    </evidence>
    <sequence length="169" mass="19004" checksum="6C506D19177D10BC" modified="2004-03-01" version="2">MSSSASTTSSGNSTIIHEEFDEKPTSNFSWPPGQAFPFEPLPPYPAGPNLSKIRYPREVTCPRYVCPHCDEQFLFHSTNGLLTCPFCYTSIAIGTYNRKQMYLNFVVGTIVLIISMVMTILVFTIAKDQVYLSIPAIMLFFGAIIFFTKALQSKDSYEEAKILIEDMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
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    <comment type="interaction">
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        <organismsDiffer>false</organismsDiffer>
        <experiments>4</experiments>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="Biochim. Biophys. Acta" volume="1823" first="1847" last="1855">
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                <person name="Datla U.S."/>
                <person name="Hollis S.E."/>
                <person name="Kimble J."/>
                <person name="Lee M.H."/>
            </authorList>
            <dbReference type="PubMed" id="22820175"/>
            <dbReference type="DOI" id="10.1016/j.bbamcr.2012.07.006"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
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        <isoform>
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        </isoform>
        <isoform>
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        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
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    <proteinExistence type="predicted"/>
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<entry dataset="Swiss-Prot" created="2002-09-19" modified="2026-01-28" version="182" xmlns="https://uniprot.org/uniprot">
    <accession>Q21734-3</accession>
    <name>KS6A1_CAEEL</name>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="Biochim. Biophys. Acta" volume="1823" first="1847" last="1855">
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            </authorList>
            <dbReference type="PubMed" id="22820175"/>
            <dbReference type="DOI" id="10.1016/j.bbamcr.2012.07.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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        <isoform>
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        <isoform>
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        </isoform>
        <isoform>
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        </isoform>
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    <dbReference type="EC" id="2.7.11.1"/>
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    <proteinExistence type="predicted"/>
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</entry>
<entry dataset="Swiss-Prot" created="2002-09-19" modified="2026-01-28" version="182" xmlns="https://uniprot.org/uniprot">
    <accession>Q21734-4</accession>
    <name>KS6A1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform d of Putative ribosomal protein S6 kinase alpha-1</fullName>
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    <gene>
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    <organism>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="Biochim. Biophys. Acta" volume="1823" first="1847" last="1855">
            <title>The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline.</title>
            <authorList>
                <person name="Cha D.S."/>
                <person name="Datla U.S."/>
                <person name="Hollis S.E."/>
                <person name="Kimble J."/>
                <person name="Lee M.H."/>
            </authorList>
            <dbReference type="PubMed" id="22820175"/>
            <dbReference type="DOI" id="10.1016/j.bbamcr.2012.07.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21734-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_020793 VSP_020795 VSP_020794"/>
        </isoform>
        <isoform>
            <id>Q21734-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_009636"/>
        </isoform>
        <isoform>
            <id>Q21734-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q21734-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_004797 VSP_004796"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="RefSeq" id="NP_001021603.1">
        <property type="nucleotide sequence ID" value="NM_001026432.5"/>
    </dbReference>
    <dbReference type="WormBase" id="T01H8.1d">
        <property type="protein sequence ID" value="CE38217"/>
        <property type="gene ID" value="WBGene00011352"/>
        <property type="gene designation" value="rskn-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="734" mass="83520" checksum="3D42762FD9AED087" modified="2004-03-15" version="4"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="188" xmlns="https://uniprot.org/uniprot">
    <accession>Q21994</accession>
    <name>Q21994_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">prps-1</name>
        <name evidence="15" type="ORF">CELE_R151.2</name>
        <name evidence="17" type="ORF">R151.2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. The active form is probably a hexamer composed of 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD70751.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T16763">
        <property type="entry name" value="T16763"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_498586.2">
        <property type="nucleotide sequence ID" value="NM_066185.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q21994"/>
    <dbReference type="SMR" id="Q21994"/>
    <dbReference type="DIP" id="DIP-27352N"/>
    <dbReference type="IntAct" id="Q21994">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q21994"/>
    <dbReference type="GeneID" id="176016"/>
    <dbReference type="UCSC" id="R151.2d.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020107"/>
    <dbReference type="CTD" id="176016"/>
    <dbReference type="WormBase" id="R151.2a">
        <property type="protein sequence ID" value="CE48009"/>
        <property type="gene ID" value="WBGene00020107"/>
        <property type="gene designation" value="prps-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_1_0_1"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020107">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q21994">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000011">
        <property type="entry name" value="Putative ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="14">
        <location>
            <begin position="62"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD70751.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="R151.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="Q21994"/>
        </source>
    </evidence>
    <sequence length="377" mass="41204" checksum="08391DB21CF59F92" modified="2013-02-06" version="2">MAGGLFKLMKDKSVDHSHLHKDHSIHHPTPPRSFFSSSSLAVHPNVETAQSSSEEDLRMPNIKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIASSCRVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNWQTSVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADKVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDENMKKCSKIQCIDISMILAEAIRRTHNGESVSYLFSHVPIC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-04-29" modified="2026-01-28" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q23045-2</accession>
    <name>EGL13_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Transcription factor egl-13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein egg laying defective 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">egl-13</name>
        <name evidence="6" type="synonym">cog-2</name>
        <name evidence="6" type="ORF">T22B7.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="1999" name="Development" volume="126" first="169" last="179">
            <title>COG-2, a sox domain protein necessary for establishing a functional vulval-uterine connection in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hanna-Rose W."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="9834196"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ALA-335</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2003" name="Genetics" volume="165" first="1623" last="1628">
            <title>The EGL-13 SOX domain transcription factor affects the uterine pi cell lineages in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Cinar H.N."/>
                <person name="Richards K.L."/>
                <person name="Oommen K.S."/>
                <person name="Newman A.P."/>
            </authorList>
            <dbReference type="PubMed" id="14668410"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-331 AND PRO-394</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Development" volume="140" first="3838" last="3847">
            <title>Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression.</title>
            <authorList>
                <person name="Feng G."/>
                <person name="Yi P."/>
                <person name="Yang Y."/>
                <person name="Chai Y."/>
                <person name="Tian D."/>
                <person name="Zhu Z."/>
                <person name="Liu J."/>
                <person name="Zhou F."/>
                <person name="Cheng Z."/>
                <person name="Wang X."/>
                <person name="Li W."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="23946438"/>
            <dbReference type="DOI" id="10.1242/dev.098723"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 177-GLN--GLU-486</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003511" last="E1003511">
            <title>EGL-13/SoxD specifies distinct O2 and CO2 sensory neuron fates in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gramstrup Petersen J."/>
                <person name="Rojo Romanos T."/>
                <person name="Juozaityte V."/>
                <person name="Redo Riveiro A."/>
                <person name="Hums I."/>
                <person name="Traunmuller L."/>
                <person name="Zimmer M."/>
                <person name="Pocock R."/>
            </authorList>
            <dbReference type="PubMed" id="23671427"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003511"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-364</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q23045-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_057621"/>
        </isoform>
        <isoform>
            <id>Q23045-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q23045-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_057622"/>
        </isoform>
        <isoform>
            <id>Q23045-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_057620"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001380089.1">
        <property type="nucleotide sequence ID" value="NM_001392777.1"/>
    </dbReference>
    <dbReference type="WormBase" id="T22B7.1b">
        <property type="protein sequence ID" value="CE33702"/>
        <property type="gene ID" value="WBGene00001182"/>
        <property type="gene designation" value="egl-13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000305" key="2">
        <source>
            <dbReference type="PubMed" id="14668410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAD12252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CCD74407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T22B7.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T22B7.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T22B7.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T22B7.1d"/>
        </source>
    </evidence>
    <sequence length="316" mass="35474" checksum="1F301FEF69871D32" modified="2001-10-01" version="2">MSPMLHAGNFDSEMLLRQHELMQHQQQQMIIANMLKATQSLPLLFNGGLNYEAILNNPVLNATIAGHLPNPLASNISLLQKSISAKLAAAGNMQTVEKVETPLNLSKDTPSPTAIPQSPLSGFRLPYSLGTNYGSDGQLFNNCSPNSSGKSTPGNTSVTSEVATPRPQAKSPNHIKRPMNAFMVWARDERRKILKAYPDMHNSNISKILGSRWKGMSNSEKQPYYEEQSRLSKLHMEQHPDYRYRPRPKRTCVIDGKKVRVNEYKTIMKTKKDLMWGDEPGFSQPSDLQMDLASHVNLLNDLTQHHHQSHLLQTAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-04-29" modified="2026-01-28" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q23045-3</accession>
    <name>EGL13_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform c of Transcription factor egl-13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein egg laying defective 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">egl-13</name>
        <name evidence="6" type="synonym">cog-2</name>
        <name evidence="6" type="ORF">T22B7.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="1999" name="Development" volume="126" first="169" last="179">
            <title>COG-2, a sox domain protein necessary for establishing a functional vulval-uterine connection in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hanna-Rose W."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="9834196"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ALA-335</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2003" name="Genetics" volume="165" first="1623" last="1628">
            <title>The EGL-13 SOX domain transcription factor affects the uterine pi cell lineages in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Cinar H.N."/>
                <person name="Richards K.L."/>
                <person name="Oommen K.S."/>
                <person name="Newman A.P."/>
            </authorList>
            <dbReference type="PubMed" id="14668410"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-331 AND PRO-394</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Development" volume="140" first="3838" last="3847">
            <title>Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression.</title>
            <authorList>
                <person name="Feng G."/>
                <person name="Yi P."/>
                <person name="Yang Y."/>
                <person name="Chai Y."/>
                <person name="Tian D."/>
                <person name="Zhu Z."/>
                <person name="Liu J."/>
                <person name="Zhou F."/>
                <person name="Cheng Z."/>
                <person name="Wang X."/>
                <person name="Li W."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="23946438"/>
            <dbReference type="DOI" id="10.1242/dev.098723"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 177-GLN--GLU-486</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003511" last="E1003511">
            <title>EGL-13/SoxD specifies distinct O2 and CO2 sensory neuron fates in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gramstrup Petersen J."/>
                <person name="Rojo Romanos T."/>
                <person name="Juozaityte V."/>
                <person name="Redo Riveiro A."/>
                <person name="Hums I."/>
                <person name="Traunmuller L."/>
                <person name="Zimmer M."/>
                <person name="Pocock R."/>
            </authorList>
            <dbReference type="PubMed" id="23671427"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003511"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-364</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q23045-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q23045-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_057620"/>
        </isoform>
        <isoform>
            <id>Q23045-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_057621"/>
        </isoform>
        <isoform>
            <id>Q23045-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_057622"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001368074.1">
        <property type="nucleotide sequence ID" value="NM_001380981.1"/>
    </dbReference>
    <dbReference type="WormBase" id="T22B7.1c">
        <property type="protein sequence ID" value="CE38552"/>
        <property type="gene ID" value="WBGene00001182"/>
        <property type="gene designation" value="egl-13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000305" key="2">
        <source>
            <dbReference type="PubMed" id="14668410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAD12252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CCD74407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T22B7.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T22B7.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T22B7.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T22B7.1d"/>
        </source>
    </evidence>
    <sequence length="422" mass="46875" checksum="77BC731FB12C11C6" modified="2001-10-01" version="2">MDDTPNPAGSPHDASIKSSSSTISDHTSTSATTGISDFPDILAQTEHGCSVLIDGNHLREIINSVDTQDGKQDLLSDVIRQLTSIKERLTNDESPVKDDLKEDPDDMSPMLHAGNFDSEMLLRQHELMQHQQQQMIIANMLKATQSLPLLFNGGLNYEAILNNPVLNATIAGHLPNPLASNISLLQKSISAKLAAAGNMQTVEKVETPLNLSKDTPSPTAIPQSPLSGFRLPYSLGTNYGSDGQLFNNCSPNSSGKSTPGNTSVTSEVATPRPQAKSPNHIKRPMNAFMVWARDERRKILKAYPDMHNSNISKILGSRWKGMSNSEKQPYYEEQSRLSKLHMEQHPDYRYRPRPKRTCVIDGKKVRVNEYKTIMKTKKDLMWGDEPGFSQPSDLQMDLASHVNLLNDLTQHHHQSHLLQTAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-04-29" modified="2026-01-28" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q23045-4</accession>
    <name>EGL13_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform d of Transcription factor egl-13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein egg laying defective 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">egl-13</name>
        <name evidence="6" type="synonym">cog-2</name>
        <name evidence="6" type="ORF">T22B7.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="1999" name="Development" volume="126" first="169" last="179">
            <title>COG-2, a sox domain protein necessary for establishing a functional vulval-uterine connection in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hanna-Rose W."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="9834196"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ALA-335</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2003" name="Genetics" volume="165" first="1623" last="1628">
            <title>The EGL-13 SOX domain transcription factor affects the uterine pi cell lineages in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Cinar H.N."/>
                <person name="Richards K.L."/>
                <person name="Oommen K.S."/>
                <person name="Newman A.P."/>
            </authorList>
            <dbReference type="PubMed" id="14668410"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-331 AND PRO-394</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Development" volume="140" first="3838" last="3847">
            <title>Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression.</title>
            <authorList>
                <person name="Feng G."/>
                <person name="Yi P."/>
                <person name="Yang Y."/>
                <person name="Chai Y."/>
                <person name="Tian D."/>
                <person name="Zhu Z."/>
                <person name="Liu J."/>
                <person name="Zhou F."/>
                <person name="Cheng Z."/>
                <person name="Wang X."/>
                <person name="Li W."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="23946438"/>
            <dbReference type="DOI" id="10.1242/dev.098723"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 177-GLN--GLU-486</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003511" last="E1003511">
            <title>EGL-13/SoxD specifies distinct O2 and CO2 sensory neuron fates in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gramstrup Petersen J."/>
                <person name="Rojo Romanos T."/>
                <person name="Juozaityte V."/>
                <person name="Redo Riveiro A."/>
                <person name="Hums I."/>
                <person name="Traunmuller L."/>
                <person name="Zimmer M."/>
                <person name="Pocock R."/>
            </authorList>
            <dbReference type="PubMed" id="23671427"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003511"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-364</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q23045-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_057622"/>
        </isoform>
        <isoform>
            <id>Q23045-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_057621"/>
        </isoform>
        <isoform>
            <id>Q23045-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_057620"/>
        </isoform>
        <isoform>
            <id>Q23045-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001294842.1">
        <property type="nucleotide sequence ID" value="NM_001307913.5"/>
    </dbReference>
    <dbReference type="WormBase" id="T22B7.1d">
        <property type="protein sequence ID" value="CE05030"/>
        <property type="gene ID" value="WBGene00001182"/>
        <property type="gene designation" value="egl-13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000305" key="2">
        <source>
            <dbReference type="PubMed" id="14668410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAD12252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CCD74407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T22B7.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T22B7.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T22B7.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T22B7.1d"/>
        </source>
    </evidence>
    <sequence length="319" mass="35932" checksum="57F13CE3C6104C9D" modified="2001-10-01" version="2">MWPMVQMLHAGNFDSEMLLRQHELMQHQQQQMIIANMLKATQSLPLLFNGGLNYEAILNNPVLNATIAGHLPNPLASNISLLQKSISAKLAAAGNMQTVEKVETPLNLSKDTPSPTAIPQSPLSGFRLPYSLGTNYGSDGQLFNNCSPNSSGKSTPGNTSVTSEVATPRPQAKSPNHIKRPMNAFMVWARDERRKILKAYPDMHNSNISKILGSRWKGMSNSEKQPYYEEQSRLSKLHMEQHPDYRYRPRPKRTCVIDGKKVRVNEYKTIMKTKKDLMWGDEPGFSQPSDLQMDLASHVNLLNDLTQHHHQSHLLQTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-01-10" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q2V4U7</accession>
    <name>Q2V4U7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">tph-1</name>
        <name evidence="13" type="ORF">CELE_ZK1290.2</name>
        <name evidence="15" type="ORF">ZK1290.2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD65930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359899.1">
        <property type="nucleotide sequence ID" value="NM_001373740.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2V4U7"/>
    <dbReference type="SMR" id="Q2V4U7"/>
    <dbReference type="GeneID" id="174227"/>
    <dbReference type="KEGG" id="cel:CELE_ZK1290.2"/>
    <dbReference type="UCSC" id="ZK1290.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
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    <dbReference type="WormBase" id="ZK1290.2b">
        <property type="protein sequence ID" value="CE39458"/>
        <property type="gene ID" value="WBGene00006600"/>
        <property type="gene designation" value="tph-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023198_0_1_1"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006600">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2V4U7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:tryptophan 5-monooxygenase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
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        <property type="evidence" value="ECO:0000315"/>
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        <property type="term" value="P:biogenic amine metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:dauer larval development"/>
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        <property type="term" value="P:determination of adult lifespan"/>
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        <property type="term" value="P:lipid storage"/>
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        <property type="term" value="P:positive regulation of transforming growth factor beta receptor signaling pathway"/>
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        <property type="term" value="P:response to axon injury"/>
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    </dbReference>
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        <property type="term" value="P:serotonin biosynthetic process from tryptophan"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRYPTOPHAN 5-HYDROXYLASE 2"/>
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    </dbReference>
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        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
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    </dbReference>
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        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="12">
        <location>
            <begin position="70"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
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        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD65930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="ZK1290.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="Q2V4U7"/>
        </source>
    </evidence>
    <sequence length="429" mass="49118" checksum="AACCD7D1CC1846A6" modified="2006-01-10" version="1">MIANLPDHTRIKHLETRDSQDGSSKTMDVLLEIELFHYGKQEAMDLMRLNGLDVHEVSSTIRPTAIKEQYTEPGSDDATTGSEWFPKSIYDLDICAKRVIMYGAGLDADHPGFKDTEYRQRRMMFAELALNYKHGEPIPRTEYTSSERKTWGIIYRKLRELHKKHACKQFLDNFELLERHCGYSENNIPQLEDICKFLKAKTGFRVRPVAGYLSARDFLAGLAYRVFFCTQYVRHHADPFYTPEPDTVHELMGHMALFADPDFAQFSQEIGLASLGASEEDLKKLATLYFFSIEFGLSSDDAADSPVKENGSNHERFKVYGAGLLSSAGELQHAVEGSATIIRFDPDRVVEQECLITTFQSAYFYTRNFEEAQQKLRMFTNNMKRPFIVRYNPYTESVEVLNNSRSIMLAVNSLRSDINLLAGALHYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>U4PER3</accession>
    <name>U4PER3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C6H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">map-1</name>
        <name evidence="3" type="ORF">CELE_Y37E11AL.7</name>
        <name evidence="5" type="ORF">Y37E11AL.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001417869.1">
        <property type="nucleotide sequence ID" value="NM_001430921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PER3"/>
    <dbReference type="SMR" id="U4PER3"/>
    <dbReference type="PeptideAtlas" id="U4PER3"/>
    <dbReference type="GeneID" id="177128"/>
    <dbReference type="AGR" id="WB:WBGene00003129"/>
    <dbReference type="CTD" id="177128"/>
    <dbReference type="WormBase" id="Y37E11AL.7b">
        <property type="protein sequence ID" value="CE48687"/>
        <property type="gene ID" value="WBGene00003129"/>
        <property type="gene designation" value="map-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132792_0_0_1"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003129">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PER3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y37E11AL.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="U4PER3"/>
        </source>
    </evidence>
    <sequence length="215" mass="24368" checksum="438E19E767A1E2A9" modified="2013-12-11" version="1">MDDLEGKKCIGCQKPAKLRCPTCIKMSLPDAYFCDQSCFKAFWPIHKFSHSDVNGPYNPWPCYSFTGSLRPGRVTDRRPVPDHIPRPDYALHPQGVSLEERQSKSERVIKVLTDEEKEGLKVACKLGRECLNEAAKACGPGVTTEEIDRVVHEAAIERDCYPSPLGYYKFPKSCCTSVNEVICHGIPDMRKLENGDLCNGNEDYRFCRKNIDFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4PER8</accession>
    <name>U4PER8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y55F3BR.2</name>
        <name evidence="2 4" type="ORF">Y55F3BR.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294460.1">
        <property type="nucleotide sequence ID" value="NM_001307531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PER8"/>
    <dbReference type="GeneID" id="190314"/>
    <dbReference type="AGR" id="WB:WBGene00021939"/>
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        <property type="gene ID" value="WBGene00021939"/>
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        <property type="entry name" value="Cys_repeat_1"/>
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        <property type="entry name" value="EB_dom"/>
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        <property type="entry name" value="Lustrin_cystein"/>
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        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
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        <property type="match status" value="2"/>
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        <location>
            <begin position="409"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="465"/>
            <end position="516"/>
        </location>
    </feature>
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            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
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        <source>
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            <fullName evidence="1">Inappropriate Vulval cell Proliferation Homolog</fullName>
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        <name evidence="1 3" type="primary">ivph-3</name>
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    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">Bristol N2</strain>
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    <dbReference type="EMBL" id="BX284604">
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    <dbReference type="AGR" id="WB:WBGene00022067"/>
    <dbReference type="CTD" id="177086"/>
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        <property type="protein sequence ID" value="CE49117"/>
        <property type="gene ID" value="WBGene00022067"/>
        <property type="gene designation" value="ivph-3"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5784093at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022067">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PES1">
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93237.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y67D8C.3d"/>
        </source>
    </evidence>
    <sequence length="43" mass="4869" checksum="BC9FBDB1C5A51FAB" modified="2013-12-11" version="1">MEVDANVEETEILEDVKLELVEQPAPEIVLQEIKAEEPDDFTA</sequence>
</entry>
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    <accession>U4PES6</accession>
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            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
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        <name evidence="16 18" type="primary">eel-1</name>
        <name evidence="16" type="ORF">CELE_Y67D8C.5</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16 17">Bristol N2</strain>
        </source>
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            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        <subcellularLocation>
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        </subcellularLocation>
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        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
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        <property type="gene designation" value="eel-1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
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        <property type="entry name" value="Enhancer of EfL-1 mutant phenotype"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
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        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
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        <property type="entry name" value="E3_ubiq-protein_ligase"/>
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        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
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        <property type="entry name" value="HUWE1/Rev1_UBM"/>
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        <property type="entry name" value="UBA-like_sf"/>
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        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
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    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="14">
        <location>
            <begin position="1436"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
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            <end position="4182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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    <feature type="region of interest" description="Disordered" evidence="13">
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="2065"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="2555"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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            <end position="2944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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            <end position="3662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="3715"/>
            <end position="3734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="2179"/>
            <end position="2218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
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            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <end position="824"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
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            <end position="2812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2813"/>
            <end position="2829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2837"/>
            <end position="2853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2854"/>
            <end position="2874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2891"/>
            <end position="2901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2902"/>
            <end position="2917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2925"/>
            <end position="2936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="3012"/>
            <end position="3039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="3602"/>
            <end position="3614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="3615"/>
            <end position="3649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="3715"/>
            <end position="3725"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="4149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDH93242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="Y67D8C.5f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="U4PES6"/>
        </source>
    </evidence>
    <sequence length="4182" mass="466044" checksum="ED85653512B30639" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4PET2</accession>
    <name>U4PET2_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y67D8C.22</name>
        <name evidence="2 4" type="ORF">Y67D8C.22</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294475.1">
        <property type="nucleotide sequence ID" value="NM_001307546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PET2"/>
    <dbReference type="GeneID" id="24105192"/>
    <dbReference type="AGR" id="WB:WBGene00235279"/>
    <dbReference type="CTD" id="24105192"/>
    <dbReference type="WormBase" id="Y67D8C.22b">
        <property type="protein sequence ID" value="CE48652"/>
        <property type="gene ID" value="WBGene00235279"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106558_1_0_1"/>
    <dbReference type="OrthoDB" id="10012538at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00235279">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PET2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y67D8C.22b"/>
        </source>
    </evidence>
    <sequence length="66" mass="7603" checksum="C2781A99CF81A6E1" modified="2013-12-11" version="1">MLLEEHHDIGFTTFNQASLSYAFYMSLCGLVALYIPPLTLVVFTEKLTIRERSKTPNNFDPTVMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF39</accession>
    <name>U4PF39_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">plx-1</name>
        <name evidence="15" type="ORF">CELE_Y55F3AL.1</name>
        <name evidence="17" type="ORF">Y55F3AL.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294555.1">
        <property type="nucleotide sequence ID" value="NM_001307626.3"/>
    </dbReference>
    <dbReference type="SMR" id="U4PF39"/>
    <dbReference type="PeptideAtlas" id="U4PF39"/>
    <dbReference type="GeneID" id="246019"/>
    <dbReference type="AGR" id="WB:WBGene00004047"/>
    <dbReference type="CTD" id="246019"/>
    <dbReference type="WormBase" id="Y55F3AL.1c">
        <property type="protein sequence ID" value="CE48844"/>
        <property type="gene ID" value="WBGene00004047"/>
        <property type="gene designation" value="plx-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004047">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF39">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01180">
        <property type="entry name" value="IPT_plexin_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12790">
        <property type="entry name" value="RasGAP_plexin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11236">
        <property type="entry name" value="Sema_plexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000033">
        <property type="entry name" value="PLeXin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000036">
        <property type="entry name" value="PLeXin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002538">
        <property type="entry name" value="PLeXin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000421">
        <property type="entry name" value="Plexin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1069"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="14">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDH93354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="Y55F3AL.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="U4PF39"/>
        </source>
    </evidence>
    <sequence length="1767" mass="197346" checksum="F2E7D477628EE1C5" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF47</accession>
    <name>U4PF47_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">dnj-15</name>
        <name evidence="4" type="ORF">CELE_K08D10.2</name>
        <name evidence="6" type="ORF">K08D10.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294564.1">
        <property type="nucleotide sequence ID" value="NM_001307635.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PF47"/>
    <dbReference type="SMR" id="U4PF47"/>
    <dbReference type="PeptideAtlas" id="U4PF47"/>
    <dbReference type="GeneID" id="187149"/>
    <dbReference type="KEGG" id="cel:CELE_K08D10.2"/>
    <dbReference type="AGR" id="WB:WBGene00001033"/>
    <dbReference type="CTD" id="187149"/>
    <dbReference type="WormBase" id="K08D10.2b">
        <property type="protein sequence ID" value="CE49045"/>
        <property type="gene ID" value="WBGene00001033"/>
        <property type="gene designation" value="dnj-15"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068529_0_2_1"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001033">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF47">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.20:FF:000011">
        <property type="entry name" value="DNaJ domain (Prokaryotic heat shock protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDH93364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="K08D10.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="U4PF47"/>
        </source>
    </evidence>
    <sequence length="156" mass="18511" checksum="E81D35E2C718D6A2" modified="2013-12-11" version="1">MGVKFDFRLDQDELKQKFHQLQSKLHPDKFVMATDEEKKLSEEHSRKLNEAYKELADPFKRAKYLIKEYGEEHPENLQNSEILMEMLERNEEIDEMHDENALKAEKSRIETEIDEQLEQLGTHFESKKIPEARDVIGRLTYLYSLKNTVNTKLGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF58</accession>
    <name>U4PF58_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">dpm-1</name>
        <name evidence="3" type="ORF">CELE_Y66H1A.2</name>
        <name evidence="5" type="ORF">Y66H1A.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368307.1">
        <property type="nucleotide sequence ID" value="NM_001380009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PF58"/>
    <dbReference type="PeptideAtlas" id="U4PF58"/>
    <dbReference type="GeneID" id="176874"/>
    <dbReference type="KEGG" id="cel:CELE_Y66H1A.2"/>
    <dbReference type="AGR" id="WB:WBGene00022044"/>
    <dbReference type="CTD" id="176874"/>
    <dbReference type="WormBase" id="Y66H1A.2b">
        <property type="protein sequence ID" value="CE48726"/>
        <property type="gene ID" value="WBGene00022044"/>
        <property type="gene designation" value="dpm-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022044">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF58">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y66H1A.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="U4PF58"/>
        </source>
    </evidence>
    <sequence length="51" mass="5959" checksum="6EB83DDAA262C1E8" modified="2013-12-11" version="1">MEMMFRAKKSGYRIGEVPISFVDRFFGESKLGSQEIVDYAKGLLYLFAFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>W6RTE8</accession>
    <name>W6RTE8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">clec-51</name>
        <name evidence="4" type="ORF">B0218.6</name>
        <name evidence="2" type="ORF">CELE_B0218.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368439.1">
        <property type="nucleotide sequence ID" value="NM_001380354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RTE8"/>
    <dbReference type="SMR" id="W6RTE8"/>
    <dbReference type="PeptideAtlas" id="W6RTE8"/>
    <dbReference type="GeneID" id="181854"/>
    <dbReference type="KEGG" id="cel:CELE_B0218.6"/>
    <dbReference type="AGR" id="WB:WBGene00015050"/>
    <dbReference type="CTD" id="181854"/>
    <dbReference type="WormBase" id="B0218.6b">
        <property type="protein sequence ID" value="CE49543"/>
        <property type="gene ID" value="WBGene00015050"/>
        <property type="gene designation" value="clec-51"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059077_0_0_1"/>
    <dbReference type="OrthoDB" id="5877119at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015050">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RTE8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000091">
        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="51"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM63502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="B0218.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="W6RTE8"/>
        </source>
    </evidence>
    <sequence length="184" mass="20707" checksum="73801160932ED41F" modified="2014-04-16" version="1">MQLQTGTAKWQTTNCTAQLPFICSYSSSVTPTCPSVTIPSHCPSGYTWYDETDFCYKNTVRFTSFNDARSSCQADGGDLASIHSANENQFLVDLSKAGITNKDKSHSDDVFIGLVYQNSKWQWTDGSAVNFLNWGDGEPNNMDKEWWTSLVADPHEDKNTENTRWNNVAQIDMRAFICKKAPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y40C5A.4d"/>
        </source>
    </evidence>
    <sequence length="293" mass="33210" checksum="89C971C4F6734A6B" modified="2014-04-16" version="1">MAGFSLEESAVKILGVTIAVIGAIYLIYPPGLLLIPLSLFIFSYTTKNEKCSSKNVDTFFSGFKIGGHRGAPKSFPENSMAGFAQAKADGADLIEFDVALTKDGKAVLMHDDDLDRTTDMKGPIRDKTRAELDRCDISATFKRTAPGDHCRLATVSRERVPDMEDVVKWAVENNTRMLFDVKDSDNELVDQIANLFQKYNLYDKAIVCSFFPWVVYRIKKGDQKILTGLTWRLKFWSYHDIENIRPRYSGPKQMLFEMIDVAHVWLLKKVTPWYLGADLLLTNNLDISQFMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0M9JJE1</accession>
    <name>A0A0M9JJE1_CAEEL</name>
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        <submittedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5 7" type="primary">nhr-59</name>
        <name evidence="5" type="ORF">CELE_T27B7.1</name>
        <name evidence="7" type="ORF">T27B7.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CUR30048.1"/>
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        <property type="nucleotide sequence ID" value="NM_001316820.3"/>
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    <dbReference type="CTD" id="178707"/>
    <dbReference type="WormBase" id="T27B7.1b">
        <property type="protein sequence ID" value="CE51053"/>
        <property type="gene ID" value="WBGene00003649"/>
        <property type="gene designation" value="nhr-59"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5848321at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003649">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0M9JJE1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051152">
        <property type="entry name" value="C.elegans_Orphan_NR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680:SF2">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="76"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUR30048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="T27B7.1b"/>
        </source>
    </evidence>
    <sequence length="330" mass="38346" checksum="2F95AC5912FBB80C" modified="2015-12-09" version="1">MDIQNFQFNRDSFATSTKVAPSLSTFLGRPEFLLSCSPGTSASTSQNKFIDLSPFIKNCKQVLMDDRKIPLAPGKTRLQKLSSSLDFEISANNKKKKTDLRKVSTLGFSEAIQIFENELLMTSKWLAHFEEFHDLGNDFKFKFLECTWNIWNRLERVARTAALLRDQKISNGKGNEIILARNCVIDLRTVKFEVEWFTNYSLSEISYFIEGVGDWSMNKPLQAIIDFNPTEIELNFMLAQISLTCASKQMDSQYQETIDNLQKLIADDLHSYYIKEMRLPVYSSRIQKMMKVNNMVLRVMWERKEKLSIARMFNIFNPNFSHPELVKDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0RCW6</accession>
    <name>A0A2X0RCW6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">twk-2</name>
        <name evidence="12" type="ORF">CELE_T12C9.3</name>
        <name evidence="14" type="ORF">T12C9.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SPS41579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001350986.1">
        <property type="nucleotide sequence ID" value="NM_001364060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2X0RCW6"/>
    <dbReference type="GeneID" id="188452"/>
    <dbReference type="KEGG" id="cel:CELE_T12C9.3"/>
    <dbReference type="AGR" id="WB:WBGene00006657"/>
    <dbReference type="CTD" id="188452"/>
    <dbReference type="WormBase" id="T12C9.3c">
        <property type="protein sequence ID" value="CE52677"/>
        <property type="gene ID" value="WBGene00006657"/>
        <property type="gene designation" value="twk-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006657">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2X0RCW6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF110">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="163"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="286"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="614"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="789"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="962"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="962"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SPS41579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T12C9.3c"/>
        </source>
    </evidence>
    <sequence length="1231" mass="141089" checksum="2AA98CF875DBB210" modified="2018-09-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-06-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A486WTI5</accession>
    <name>A0A486WTI5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ectopic P granules protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">epg-3</name>
        <name evidence="3" type="ORF">CELE_Y37D8A.22</name>
        <name evidence="5" type="ORF">Y37D8A.22</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="VGM69508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360488.1">
        <property type="nucleotide sequence ID" value="NM_001372670.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A486WTI5"/>
    <dbReference type="SMR" id="A0A486WTI5"/>
    <dbReference type="GeneID" id="176712"/>
    <dbReference type="AGR" id="WB:WBGene00012559"/>
    <dbReference type="CTD" id="176712"/>
    <dbReference type="WormBase" id="Y37D8A.22d">
        <property type="protein sequence ID" value="CE53129"/>
        <property type="gene ID" value="WBGene00012559"/>
        <property type="gene designation" value="epg-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016540at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A486WTI5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VGM69508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y37D8A.22d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A486WTI5"/>
        </source>
    </evidence>
    <sequence length="421" mass="47687" checksum="7A275583E4B68D71" modified="2019-06-05" version="1">MKPSPSQNTLNRMERETIVFWRRPHIVIPYALMEIAHLAVELFFKILAHKTVLLLTAISIGLAVYGYHAPGAHQEHVQTIEKHILWWSWWVLLGVLSSIGLGSGLHTFLIYLGPHIAAVTMAAYECQSLDFPQPPYPESIQCPSTKSSIAVTFWQIVAKVRVESLLWGAGTALGELPPYFMARAARISGQEPDDEEYREFLELMNADKESDADQKLSIVERAKSWVEHNIHRLGFPGILLFASIPNPLFDLAGITCGHFLVPFWSFFGATLIGKALVKMHVQMGFVILAFSDHHAENFVKILEKIPAVGPYIRQPISDLLEKQRKALHKTPGEHSEQSTSYLAWGLSLMVTFMILFFFLSIVNSLAKDYHKRLWERKRRQNKDLIDEENQSFEEEEEEAVTPPSSCPLLLSDGFEGVVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>E3W722</accession>
    <name>E3W722_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">B0507.5</name>
        <name evidence="1" type="ORF">CELE_B0507.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD62080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256109.1">
        <property type="nucleotide sequence ID" value="NM_001269180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E3W722"/>
    <dbReference type="GeneID" id="182012"/>
    <dbReference type="AGR" id="WB:WBGene00015222"/>
    <dbReference type="CTD" id="182012"/>
    <dbReference type="WormBase" id="B0507.5b">
        <property type="protein sequence ID" value="CE45467"/>
        <property type="gene ID" value="WBGene00015222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD62080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="B0507.5b"/>
        </source>
    </evidence>
    <sequence length="184" mass="22401" checksum="20305A1A730324E1" modified="2011-01-11" version="1">MFPSELLPVFVIFFLPELEKTSIFATLFLQLLESLYYQFNEFVQTDSNILYIFKKNPTDRFDTNFIFYWFWIQFETLLNARYYDLSQKINEIFNPSFPKNYEEKSNQLKDEIFPIFLDFFNFLEMENHATITKDKSSNDKYQIINIPLKCPISFIKNDYKYNKIYILLWQTKLMINPLKKALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>E3W740</accession>
    <name>E3W740_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNAi-Induced Longevity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ril-2</name>
        <name evidence="8" type="ORF">C14C10.3</name>
        <name evidence="6" type="ORF">CELE_C14C10.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBX53314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256436.1">
        <property type="nucleotide sequence ID" value="NM_001269507.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E3W740"/>
    <dbReference type="GeneID" id="179725"/>
    <dbReference type="AGR" id="WB:WBGene00007586"/>
    <dbReference type="CTD" id="179725"/>
    <dbReference type="WormBase" id="C14C10.3c">
        <property type="protein sequence ID" value="CE45516"/>
        <property type="gene ID" value="WBGene00007586"/>
        <property type="gene designation" value="ril-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5805943at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007586">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E3W740">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF3">
        <property type="entry name" value="RNAI-INDUCED LONGEVITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBX53314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="C14C10.3c"/>
        </source>
    </evidence>
    <sequence length="633" mass="71616" checksum="93C238EAB5F2D3FC" modified="2011-01-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>E3W741</accession>
    <name>E3W741_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ttr-44</name>
        <name evidence="7" type="ORF">C56A3.2</name>
        <name evidence="5" type="ORF">CELE_C56A3.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBX53317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367269.1">
        <property type="nucleotide sequence ID" value="NM_001380804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E3W741"/>
    <dbReference type="SMR" id="E3W741"/>
    <dbReference type="PeptideAtlas" id="E3W741"/>
    <dbReference type="GeneID" id="179835"/>
    <dbReference type="AGR" id="WB:WBGene00008341"/>
    <dbReference type="CTD" id="179835"/>
    <dbReference type="WormBase" id="C56A3.2b">
        <property type="protein sequence ID" value="CE45479"/>
        <property type="gene ID" value="WBGene00008341"/>
        <property type="gene designation" value="ttr-44"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121109_4_1_1"/>
    <dbReference type="OrthoDB" id="5822973at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E3W741">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF118">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBX53317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C56A3.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="E3W741"/>
        </source>
    </evidence>
    <sequence length="144" mass="16475" checksum="6F4628E9D3B5CB4E" modified="2011-01-11" version="1">MVQAMRDQSIAVKGRLICGDKPAANVRIKLWEEDSGPDPDDLLEAGYTDSNGEFQLSGGEAELTPIDPIFKVYHDCDDKYIPGHRKVKFLIPKSYITQGKTPKKTFDLGVLNLETIFPKEERELIVSRKRRHHPKQYINEEDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>E3W742</accession>
    <name>E3W742_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">frpr-5</name>
        <name evidence="3" type="ORF">C56A3.3</name>
        <name evidence="1" type="ORF">CELE_C56A3.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBX53318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256518.1">
        <property type="nucleotide sequence ID" value="NM_001269589.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E3W742"/>
    <dbReference type="SMR" id="E3W742"/>
    <dbReference type="GeneID" id="183856"/>
    <dbReference type="KEGG" id="cel:CELE_C56A3.3"/>
    <dbReference type="AGR" id="WB:WBGene00008342"/>
    <dbReference type="CTD" id="183856"/>
    <dbReference type="WormBase" id="C56A3.3c">
        <property type="protein sequence ID" value="CE45478"/>
        <property type="gene ID" value="WBGene00008342"/>
        <property type="gene designation" value="frpr-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038309_0_0_1"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E3W742">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBX53318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C56A3.3c"/>
        </source>
    </evidence>
    <sequence length="51" mass="5875" checksum="032FCB8504779214" modified="2011-01-11" version="1">MKMQISSRTPKRWLAEVNIVDVESSNGRHPRIYVRPLNQLPNNETISITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>E3W743</accession>
    <name>E3W743_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">hpo-34</name>
        <name evidence="2" type="ORF">CELE_F29G6.3</name>
        <name evidence="4" type="ORF">F29G6.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CBX53322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367270.1">
        <property type="nucleotide sequence ID" value="NM_001381107.1"/>
    </dbReference>
    <dbReference type="IntAct" id="E3W743">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="E3W743"/>
    <dbReference type="GeneID" id="181340"/>
    <dbReference type="AGR" id="WB:WBGene00009259"/>
    <dbReference type="CTD" id="181340"/>
    <dbReference type="WormBase" id="F29G6.3d">
        <property type="protein sequence ID" value="CE45461"/>
        <property type="gene ID" value="WBGene00009259"/>
        <property type="gene designation" value="hpo-34"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_266701_0_0_1"/>
    <dbReference type="OrthoDB" id="5823380at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009259">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E3W743">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBX53322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F29G6.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="E3W743"/>
        </source>
    </evidence>
    <sequence length="1362" mass="154732" checksum="53618606347A3713" modified="2011-01-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>E3W744</accession>
    <name>E3W744_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1</fullName>
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        <name evidence="4 6" type="ORF">C27A7.3</name>
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    </gene>
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    </organism>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
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    </dbReference>
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        <property type="protein sequence ID" value="CE45469"/>
        <property type="gene ID" value="WBGene00007755"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007755">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E3W744">
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF114">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBX53315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C27A7.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="E3W744"/>
        </source>
    </evidence>
    <sequence length="725" mass="82407" checksum="09B57CB3F9C4FE25" modified="2011-01-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>E3W745</accession>
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        <submittedName>
            <fullName evidence="4">Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1</fullName>
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        <name evidence="4 6" type="ORF">C27A7.3</name>
        <name evidence="4" type="ORF">CELE_C27A7.3</name>
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    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference evidence="4 5" key="1">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">Bristol N2</strain>
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    </reference>
    <dbReference type="EMBL" id="BX284605">
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    <dbReference type="AGR" id="WB:WBGene00007755"/>
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        <property type="gene ID" value="WBGene00007755"/>
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    <dbReference type="OrthoDB" id="415411at2759"/>
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    <dbReference type="Bgee" id="WBGene00007755">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="E3W745">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
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    </dbReference>
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        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.3"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003183004" evidence="3">
        <location>
            <begin position="17"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBX53316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C27A7.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="E3W745"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>E3W751</accession>
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        <submittedName>
            <fullName evidence="2">Chitinase</fullName>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
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    </reference>
    <dbReference type="EMBL" id="BX284605">
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        <property type="gene ID" value="WBGene00012069"/>
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    <dbReference type="HOGENOM" id="CLU_153411_1_0_1"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012069">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E3W751">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22412:SF3">
        <property type="entry name" value="CEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22412">
        <property type="entry name" value="GLYCINE-RICH PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBX53340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T26H5.4b"/>
        </source>
    </evidence>
    <sequence length="79" mass="7845" checksum="3852944E981C9AD2" modified="2011-01-11" version="1">MTSAMLSGSGAAAETEMSSDNSTSTGGAGGGGSGEASSKTFTTTKKKQNMKCYEYEDGTKDDGAVLKPGVTYTATATAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>E3W752</accession>
    <name>E3W752_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">sac-2</name>
        <name evidence="3" type="ORF">CELE_W09C5.7</name>
        <name evidence="5" type="ORF">W09C5.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CBX53341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001364672.1">
        <property type="nucleotide sequence ID" value="NM_001377672.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E3W752"/>
    <dbReference type="SMR" id="E3W752"/>
    <dbReference type="PeptideAtlas" id="E3W752"/>
    <dbReference type="GeneID" id="173236"/>
    <dbReference type="AGR" id="WB:WBGene00012353"/>
    <dbReference type="CTD" id="173236"/>
    <dbReference type="WormBase" id="W09C5.7b">
        <property type="protein sequence ID" value="CE45488"/>
        <property type="gene ID" value="WBGene00012353"/>
        <property type="gene designation" value="sac-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008079_1_0_1"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012353">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E3W752">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBX53341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W09C5.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="E3W752"/>
        </source>
    </evidence>
    <sequence length="404" mass="44545" checksum="E9B1DB000BB7423B" modified="2011-01-11" version="1">MEETLKTIGFCWVDKTGEVVQSQKGVVRTNCIDCLDRTNLVQGQISLFVVLQQAQRLGIFGPLCEPPEVLVQTMQTMWADNGDVISTQYAGTAALKGDVTRNGERKLMGVMKDGYNSASRYYLTHTKDAQRQKAINIVTGQTEADENAEEEENEKEEEENISRMVTETIQFLVPTQQTVIAGWGLINAFQSSDEIDTVVILTRSNLYIVTYEIDGEKMTDVQIVALEDINTIQTGTSGNNRQCARLETLEGVFIWRPSTVRLFNNTAIRLKSLEEANEYISSVAEQIQVGRNMLTGAEGSVVPVAKITIPQMSVHRKSMAAMGALFGKIKRVGKPSSLSKSASTISTAQLPETDGNESDASQKSDHLMTKILKMSQFKSDSPQPEPFSSLLPAISECQTKISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>E3W753</accession>
    <name>E3W753_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">sac-2</name>
        <name evidence="3" type="ORF">CELE_W09C5.7</name>
        <name evidence="5" type="ORF">W09C5.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CBX53342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001252208.1">
        <property type="nucleotide sequence ID" value="NM_001265279.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E3W753"/>
    <dbReference type="SMR" id="E3W753"/>
    <dbReference type="PeptideAtlas" id="E3W753"/>
    <dbReference type="GeneID" id="173236"/>
    <dbReference type="AGR" id="WB:WBGene00012353"/>
    <dbReference type="CTD" id="173236"/>
    <dbReference type="WormBase" id="W09C5.7c">
        <property type="protein sequence ID" value="CE45503"/>
        <property type="gene ID" value="WBGene00012353"/>
        <property type="gene designation" value="sac-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008079_1_0_1"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012353">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E3W753">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol phosphatase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBX53342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W09C5.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="E3W753"/>
        </source>
    </evidence>
    <sequence length="241" mass="26326" checksum="274C51B0317EE817" modified="2011-01-11" version="1">MVTETIQFLVPTQQTVIAGWGLINAFQSSDEIDTVVILTRSNLYIVTYEIDGEKMTDVQIVALEDINTIQTGTSGNNRQCARLETLEGVFIWRPSTVRLFNNTAIRLKSLEEANEYISSVAEQIQVGRNMLTGAEGSVVPVAKITIPQMSVHRKSMAAMGALFGKIKRVGKPSSLSKSASTISTAQLPETDGNESDASQKSDHLMTKILKMSQFKSDSPQPEPFSSLLPAISECQTKISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-01-11" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>E3W759</accession>
    <name>E3W759_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_H01G02.1</name>
        <name evidence="2 4" type="ORF">H01G02.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBX53329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255590.1">
        <property type="nucleotide sequence ID" value="NM_001268661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E3W759"/>
    <dbReference type="PeptideAtlas" id="E3W759"/>
    <dbReference type="GeneID" id="186661"/>
    <dbReference type="KEGG" id="cel:CELE_H01G02.1"/>
    <dbReference type="AGR" id="WB:WBGene00010348"/>
    <dbReference type="CTD" id="186661"/>
    <dbReference type="WormBase" id="H01G02.1b">
        <property type="protein sequence ID" value="CE45421"/>
        <property type="gene ID" value="WBGene00010348"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5837354at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010348">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E3W759">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003182954" evidence="1">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBX53329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="H01G02.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="E3W759"/>
        </source>
    </evidence>
    <sequence length="126" mass="13910" checksum="2FE799F974BC3D41" modified="2011-01-11" version="1">MPSTVPSLLLFSLLMFNMAVLPYAQYVGARAYILQQRMECKGGKVYDIDNVQDIEQCKEACRQFDCDAVNLFQVGEFAFKCEILSFVSNLQPANGAACYYAQDAVGAGGNNNYNGGFGYPGYGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5P2</accession>
    <name>F3Y5P2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase A(2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">ipla-3</name>
        <name evidence="2" type="ORF">CELE_W07A8.2</name>
        <name evidence="4" type="ORF">W07A8.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCA65656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256946.1">
        <property type="nucleotide sequence ID" value="NM_001270017.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5P2"/>
    <dbReference type="SMR" id="F3Y5P2"/>
    <dbReference type="PeptideAtlas" id="F3Y5P2"/>
    <dbReference type="GeneID" id="180354"/>
    <dbReference type="KEGG" id="cel:CELE_W07A8.2"/>
    <dbReference type="AGR" id="WB:WBGene00012319"/>
    <dbReference type="CTD" id="180354"/>
    <dbReference type="WormBase" id="W07A8.2d">
        <property type="protein sequence ID" value="CE46080"/>
        <property type="gene ID" value="WBGene00012319"/>
        <property type="gene designation" value="ipla-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010817_0_0_1"/>
    <dbReference type="OrthoDB" id="10021675at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012319">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5P2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047148">
        <property type="entry name" value="PLPL9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF34">
        <property type="entry name" value="85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCA65656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="W07A8.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="F3Y5P2"/>
        </source>
    </evidence>
    <sequence length="160" mass="18021" checksum="1CEA3CE84C881B66" modified="2011-06-28" version="1">MISNNPVLDLMSDIGFYNTTCQKMRIPEKMVDMGCVLSVGTGITPICPVDPSVFEMNDLFGMLRGMKNLSLVVIDQATATEGAPITRSRTWCHSLGVPYYRLNAPIFKDVILDTNDDYDLAKIMWDSVVYSHTHKKDFQELAELLKTVGTVDERKELLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5P3</accession>
    <name>F3Y5P3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TransThyretin-Related family domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ttr-25</name>
        <name evidence="5" type="ORF">CELE_Y51A2D.10</name>
        <name evidence="7" type="ORF">Y51A2D.10</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCA65667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256815.1">
        <property type="nucleotide sequence ID" value="NM_001269886.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5P3"/>
    <dbReference type="PeptideAtlas" id="F3Y5P3"/>
    <dbReference type="GeneID" id="180210"/>
    <dbReference type="AGR" id="WB:WBGene00013078"/>
    <dbReference type="CTD" id="180210"/>
    <dbReference type="WormBase" id="Y51A2D.10b">
        <property type="protein sequence ID" value="CE45890"/>
        <property type="gene ID" value="WBGene00013078"/>
        <property type="gene designation" value="ttr-25"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121109_4_1_1"/>
    <dbReference type="OrthoDB" id="5778566at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013078">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5P3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF37">
        <property type="entry name" value="TRANSTHYRETIN-RELATED FAMILY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCA65667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y51A2D.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="F3Y5P3"/>
        </source>
    </evidence>
    <sequence length="83" mass="9069" checksum="139AD38DB0ADC344" modified="2011-06-28" version="1">MDVTNTLADGTFKVVGGQNKIRKIDPKINIYHRCNHVGLCPKRVTIHVPKNAVGKGSKEAQLFDIGVLNLANKYPGEGTDCIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5P6</accession>
    <name>F3Y5P6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="3 10">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">qns-1</name>
        <name evidence="14" type="ORF">C24F3.4</name>
        <name evidence="12" type="ORF">CELE_C24F3.4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="3 10"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCA65535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255473.1">
        <property type="nucleotide sequence ID" value="NM_001268544.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5P6"/>
    <dbReference type="SMR" id="F3Y5P6"/>
    <dbReference type="PeptideAtlas" id="F3Y5P6"/>
    <dbReference type="GeneID" id="177900"/>
    <dbReference type="AGR" id="WB:WBGene00007698"/>
    <dbReference type="CTD" id="177900"/>
    <dbReference type="WormBase" id="C24F3.4b">
        <property type="protein sequence ID" value="CE46056"/>
        <property type="gene ID" value="WBGene00007698"/>
        <property type="gene designation" value="qns-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007698">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5P6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000461">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCA65535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="C24F3.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="F3Y5P6"/>
        </source>
    </evidence>
    <sequence length="632" mass="70703" checksum="E5116A4B87F3D81A" modified="2011-06-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5P7</accession>
    <name>F3Y5P7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD/GMP synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">qns-1</name>
        <name evidence="9" type="ORF">C24F3.4</name>
        <name evidence="7" type="ORF">CELE_C24F3.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCA65536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255474.1">
        <property type="nucleotide sequence ID" value="NM_001268545.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5P7"/>
    <dbReference type="SMR" id="F3Y5P7"/>
    <dbReference type="PeptideAtlas" id="F3Y5P7"/>
    <dbReference type="GeneID" id="177900"/>
    <dbReference type="AGR" id="WB:WBGene00007698"/>
    <dbReference type="CTD" id="177900"/>
    <dbReference type="WormBase" id="C24F3.4c">
        <property type="protein sequence ID" value="CE45996"/>
        <property type="gene ID" value="WBGene00007698"/>
        <property type="gene designation" value="qns-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007698">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5P7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000461">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD/GMP synthase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCA65536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C24F3.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="F3Y5P7"/>
        </source>
    </evidence>
    <sequence length="279" mass="31558" checksum="43645E3AF3DB979E" modified="2011-06-28" version="1">MASEHSSDETRQCAEGLAKNVNSSHCGIFIDTIVTSILKVFNVAYGFMPSFQSPDNRETMALQNIQARIRMVLSYLFAQLALVSHKRPGGLLVLGTANVDESLVGYLTKYDCSSADINPIGSVSKRDLRQFLEIAYEKYGMAALRCVIDSTPTAELKPLVDGKVAQTDEAEIGLTYDELSVIGRLRKPGGMGPYGMFLKLLQLWGDKYSIDEIEEKVNKFFWRYRVNRHKATVSTPAIHAENYSPDDHRNDHRPFLYPDFSYQFERIREKVVELKKNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5P8</accession>
    <name>F3Y5P8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thymidine kinase</fullName>
            <ecNumber evidence="11">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">thk-1</name>
        <name evidence="14" type="ORF">CELE_Y43C5A.5</name>
        <name evidence="16" type="ORF">Y43C5A.5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>thymidine + ATP = dTMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19130"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer. Tetramerization from dimerization is induced by ATP and increases catalytic efficiency due to a high affinity for thymidine. Tetramerization is inhibited by phosphorylation at Ser-13. Interacts (via the KEN box) with FZR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="11"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCA65650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255478.1">
        <property type="nucleotide sequence ID" value="NM_001268549.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5P8"/>
    <dbReference type="SMR" id="F3Y5P8"/>
    <dbReference type="PeptideAtlas" id="F3Y5P8"/>
    <dbReference type="GeneID" id="177913"/>
    <dbReference type="KEGG" id="cel:CELE_Y43C5A.5"/>
    <dbReference type="AGR" id="WB:WBGene00006568"/>
    <dbReference type="CTD" id="177913"/>
    <dbReference type="WormBase" id="Y43C5A.5b">
        <property type="protein sequence ID" value="CE46099"/>
        <property type="gene ID" value="WBGene00006568"/>
        <property type="gene designation" value="thk-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_0_0_1"/>
    <dbReference type="OrthoDB" id="439028at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006568">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5P8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000048">
        <property type="entry name" value="Thymidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001270">
        <property type="entry name" value="Thymidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="THYMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441:SF0">
        <property type="entry name" value="THYMIDINE KINASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCA65650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="Y43C5A.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="F3Y5P8"/>
        </source>
    </evidence>
    <sequence length="260" mass="28683" checksum="57594B79C85A2A47" modified="2011-06-28" version="1">MTCCSSNSSLSDFNTLPRCPNRVGSITVILGPMFSGKTTELLRLHDRQIIAKRTCVLVKYAGDTRYDADLVATHSKMTGQGRTVKAHRLSEVQSQIFNDEVQVVSIDEGQFFEDLAETCEELAQRGKVVCVAALNGTFERKPFPQISLLLPYANEIKQVTAVCVECGSQANFSFRSTLDKKVEVIGGSDTYTALCRECYVQKSEEKDAEEQMKTGCDKNENDITGIFLAKKEQRSDGSVSPPRKKIGLSKSMALEATART</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5Q3</accession>
    <name>F3Y5Q3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein lilliputian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">spat-2</name>
        <name evidence="2" type="ORF">CELE_Y48A6B.13</name>
        <name evidence="4" type="ORF">Y48A6B.13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCA65696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367286.1">
        <property type="nucleotide sequence ID" value="NM_001379924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5Q3"/>
    <dbReference type="SMR" id="F3Y5Q3"/>
    <dbReference type="PeptideAtlas" id="F3Y5Q3"/>
    <dbReference type="GeneID" id="3564779"/>
    <dbReference type="AGR" id="WB:WBGene00012973"/>
    <dbReference type="CTD" id="3564779"/>
    <dbReference type="WormBase" id="Y48A6B.13b">
        <property type="protein sequence ID" value="CE46050"/>
        <property type="gene ID" value="WBGene00012973"/>
        <property type="gene designation" value="spat-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5845256at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012973">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5Q3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="105"/>
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            <begin position="148"/>
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            <begin position="250"/>
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            <begin position="271"/>
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        <location>
            <begin position="325"/>
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    </feature>
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        <location>
            <begin position="435"/>
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            <begin position="450"/>
            <end position="464"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CCA65696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="Y48A6B.13b"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="F3Y5Q3"/>
        </source>
    </evidence>
    <sequence length="533" mass="57626" checksum="7FEED8B2847DF1BC" modified="2011-06-28" version="1"> </sequence>
</entry>
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        </source>
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            <begin position="24"/>
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            <begin position="48"/>
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            <begin position="69"/>
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            <begin position="123"/>
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            <begin position="233"/>
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            <begin position="248"/>
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    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="CCA65697.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="Y48A6B.13d"/>
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    </evidence>
    <evidence type="ECO:0007829" key="5">
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            <dbReference type="PeptideAtlas" id="F3Y5Q4"/>
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    </evidence>
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            <begin position="1"/>
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            <dbReference type="EMBL" id="CCA65698.1"/>
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            <dbReference type="WormBase" id="Y48A6B.13e"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CE45979"/>
        <property type="gene ID" value="WBGene00012970"/>
        <property type="gene designation" value="mecr-2"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCA65699.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y48A6B.9b"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5Q7</accession>
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        <submittedName>
            <fullName evidence="2">Protein lilliputian</fullName>
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        <name evidence="2 4" type="primary">spat-2</name>
        <name evidence="2" type="ORF">CELE_Y48A6B.13</name>
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    <organism evidence="2 3">
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCA65700.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001268172.3"/>
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    <dbReference type="AlphaFoldDB" id="F3Y5Q7"/>
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    <dbReference type="PeptideAtlas" id="F3Y5Q7"/>
    <dbReference type="GeneID" id="3564779"/>
    <dbReference type="KEGG" id="cel:CELE_Y48A6B.13"/>
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        <property type="protein sequence ID" value="CE45975"/>
        <property type="gene ID" value="WBGene00012973"/>
        <property type="gene designation" value="spat-2"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TGNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GNDSDEM"/>
    <dbReference type="OrthoDB" id="5845256at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCA65700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y48A6B.13a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="F3Y5Q7"/>
        </source>
    </evidence>
    <sequence length="601" mass="64713" checksum="5691BB0318948C1B" modified="2011-06-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5Q8</accession>
    <name>F3Y5Q8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">lact-8</name>
        <name evidence="2" type="ORF">CELE_Y42A5A.2</name>
        <name evidence="4" type="ORF">Y42A5A.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCA65647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256287.1">
        <property type="nucleotide sequence ID" value="NM_001269358.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5Q8"/>
    <dbReference type="SMR" id="F3Y5Q8"/>
    <dbReference type="MEROPS" id="S12.A12"/>
    <dbReference type="GeneID" id="189839"/>
    <dbReference type="AGR" id="WB:WBGene00012777"/>
    <dbReference type="CTD" id="189839"/>
    <dbReference type="WormBase" id="Y42A5A.2b">
        <property type="protein sequence ID" value="CE45998"/>
        <property type="gene ID" value="WBGene00012777"/>
        <property type="gene designation" value="lact-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037464_0_0_1"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012777">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5Q8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="219"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCA65647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y42A5A.2b"/>
        </source>
    </evidence>
    <sequence length="542" mass="62770" checksum="3536DBC2CF05CD93" modified="2011-06-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5Q9</accession>
    <name>F3Y5Q9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">lact-8</name>
        <name evidence="2" type="ORF">CELE_Y42A5A.2</name>
        <name evidence="4" type="ORF">Y42A5A.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCA65648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256288.1">
        <property type="nucleotide sequence ID" value="NM_001269359.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5Q9"/>
    <dbReference type="SMR" id="F3Y5Q9"/>
    <dbReference type="MEROPS" id="S12.A12"/>
    <dbReference type="GeneID" id="189839"/>
    <dbReference type="AGR" id="WB:WBGene00012777"/>
    <dbReference type="CTD" id="189839"/>
    <dbReference type="WormBase" id="Y42A5A.2c">
        <property type="protein sequence ID" value="CE46035"/>
        <property type="gene ID" value="WBGene00012777"/>
        <property type="gene designation" value="lact-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037464_0_0_1"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012777">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5Q9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="103"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCA65648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y42A5A.2c"/>
        </source>
    </evidence>
    <sequence length="426" mass="49356" checksum="1A73DA0B4C232D76" modified="2011-06-28" version="1">MTRGYYADCFQTYRNDNVSRAIIIWRKGFGKKYRIQYGTQVQEMLTDMQRTDLEPVQLASLPRLGQRRPFPRWILWHGDEFTWGNRTIPRDLSKMDHNWEALNSVIEHRMRSYDIPSISIHILRDNKMEYSASYGFADILQNIPVKTTHRYRIASVSKLVTAMTIGELLADYRHIDLLTPVFGPAGILSDVCSPCHPYLLHVRIIHLLEHSSGAWPHTSKFEFDRLEQNQTEFLMRVVQHEFPILFPGGRHMYSNIGYILLGRIIEKVSGRSYEEYAMEKVLNPIGVNATIGKEGNSQEEVTYYSHDNANAYTSWSTRRLNSAAGWAMTAEDVTKVFHHLEQYKLRRFRWIITPSAVRWNYGRGVQLGNDGSLYHIGSLAGTEAIGYTWQNVQVAILTNIRGKEQNEQTGWMEKLCRSIADGRFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-06-28" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>F3Y5R9</accession>
    <name>F3Y5R9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deoxyribonuclease TATDN2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y37H2A.1</name>
        <name evidence="4 6" type="ORF">Y37H2A.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCA65639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256782.1">
        <property type="nucleotide sequence ID" value="NM_001269853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F3Y5R9"/>
    <dbReference type="SMR" id="F3Y5R9"/>
    <dbReference type="PeptideAtlas" id="F3Y5R9"/>
    <dbReference type="GeneID" id="180186"/>
    <dbReference type="AGR" id="WB:WBGene00012562"/>
    <dbReference type="CTD" id="180186"/>
    <dbReference type="WormBase" id="Y37H2A.1b">
        <property type="protein sequence ID" value="CE45964"/>
        <property type="gene ID" value="WBGene00012562"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685574_0_0_1"/>
    <dbReference type="OrthoDB" id="5850839at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012562">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F3Y5R9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000027">
        <property type="entry name" value="putative deoxyribonuclease TATDN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363:SF1">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCA65639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y37H2A.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="F3Y5R9"/>
        </source>
    </evidence>
    <sequence length="402" mass="46487" checksum="C2D37EB3E9D7CB96" modified="2011-06-28" version="1">MVQVHTRRLGGAAPTMHHSRPPPPPLDRRPMSPQNASRPLPVRGTNYSTNGDWPDQRPTIIQQSSRINSFPNRPVANNSYHNENIPFKDIILELHEHTVPFIDSHCHVDFMYNQMVHNNPNSSLSHGLSHWIHRYPYGFPKSFYGVIANFIKPSLFVVNDGGGGNGYDIDWIINEIESNIYLGTTWGCHPHYAQEWASKDIFWQTLEHILSNAATWKVLAVGECGLDLHRCISDLEVQKMVFEKHIDLAYKYQLPLVIHCRSGQKGRAEEQCLRILKKKMDENHKFLKIHRHCFTETWEVAQMWMKQCPNVYFGYTAAIFKMRERQQLEAIRHIPLNRILLETDAPYFRPPCFEGVGPRNVCLPGMAIATARKIAEIKELPVDEVLRATFDNTRLLYQIQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZN7</accession>
    <name>H2KZN7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F41D9.2</name>
        <name evidence="2 4" type="ORF">F41D9.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_509422.1">
        <property type="nucleotide sequence ID" value="NM_077021.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZN7"/>
    <dbReference type="SMR" id="H2KZN7"/>
    <dbReference type="GeneID" id="185612"/>
    <dbReference type="AGR" id="WB:WBGene00018282"/>
    <dbReference type="CTD" id="185612"/>
    <dbReference type="WormBase" id="F41D9.2a">
        <property type="protein sequence ID" value="CE10238"/>
        <property type="gene ID" value="WBGene00018282"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5785632at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018282">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZN7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36516:SF6">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36516">
        <property type="entry name" value="PROTEIN CBG04168-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOMON" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD69041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F41D9.2a"/>
        </source>
    </evidence>
    <sequence length="168" mass="18532" checksum="6370138C42F6AE68" modified="2012-03-21" version="1">MVSKIIRIILVNVESTPCTFVTNGQQITYGVRGNTIHFRVVLTGIPPTGSGWTAIGFGNSMFSGLDVIVVRVLNGRVIVTDEFVRGFQSPVPDRQNNVQVYGLRYENGVVVASFSRSVFSTEQMDANLSGCSPWKFSVGLNRMSPQGHLFHHSQTPFHRVVCINQCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZN8</accession>
    <name>H2KZN8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">wrk-1</name>
        <name evidence="4" type="ORF">CELE_F41D9.3</name>
        <name evidence="6" type="ORF">F41D9.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024647.1">
        <property type="nucleotide sequence ID" value="NM_001029476.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZN8"/>
    <dbReference type="SMR" id="H2KZN8"/>
    <dbReference type="PeptideAtlas" id="H2KZN8"/>
    <dbReference type="GeneID" id="181093"/>
    <dbReference type="KEGG" id="cel:CELE_F41D9.3"/>
    <dbReference type="AGR" id="WB:WBGene00006942"/>
    <dbReference type="CTD" id="181093"/>
    <dbReference type="WormBase" id="F41D9.3a">
        <property type="protein sequence ID" value="CE30985"/>
        <property type="gene ID" value="WBGene00006942"/>
        <property type="gene designation" value="wrk-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034135_0_0_1"/>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006942">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZN8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002406">
        <property type="entry name" value="Wrapper/Rega-1/Klingon homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF20">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003563893" evidence="2">
        <location>
            <begin position="19"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="115"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="208"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD69042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F41D9.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZN8"/>
        </source>
    </evidence>
    <sequence length="436" mass="48483" checksum="CA1E26050204F4F2" modified="2012-03-21" version="1">MMKLVLLILGLLIASTSAQIRTKGGTLIAKEGESLTLRCEVEDPSVAIIWRKNTEVVAVDDEILDTYGGYEISMEGSTSVLTIKRVEPINSANYSCALAEPEVSVTFVIKVQVKPLVVISPDTGVYHARVGEKNLVITCHVKEGNPKPGVVWTKQAAKLPEDIKREHGGARIVITEVKKHHAGKYNCLAENIAGSDRATIDIHVAEKPWVKNEDTFIPVRKNQNASFWCTYDGTPVPQVEWLFNGYKINFNDEKFKKTSETAQRLNGYSKSTLTVGDISEEAFGDYACRISNKLGSVTAVVHVSGRPGPPQLSFDESELTWTVRAFDKILEYQLCHRLENADHFLPEDCNSVRVKKSDNNGDDKWTHTIDLSTFLEHGNKYHVQLKARNALGWGSMAKDALHVELQRIEKEEAKGASIISIISSILVTLVTMYLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZN9</accession>
    <name>H2KZN9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">wrk-1</name>
        <name evidence="4" type="ORF">CELE_F41D9.3</name>
        <name evidence="6" type="ORF">F41D9.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024648.1">
        <property type="nucleotide sequence ID" value="NM_001029477.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZN9"/>
    <dbReference type="SMR" id="H2KZN9"/>
    <dbReference type="PeptideAtlas" id="H2KZN9"/>
    <dbReference type="GeneID" id="181093"/>
    <dbReference type="AGR" id="WB:WBGene00006942"/>
    <dbReference type="CTD" id="181093"/>
    <dbReference type="WormBase" id="F41D9.3b">
        <property type="protein sequence ID" value="CE30986"/>
        <property type="gene ID" value="WBGene00006942"/>
        <property type="gene designation" value="wrk-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006942">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZN9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002406">
        <property type="entry name" value="Wrapper/Rega-1/Klingon homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002541">
        <property type="entry name" value="Wrapper/Rega-1/Klingon homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF20">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564249" evidence="2">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="115"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="216"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD69043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F41D9.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZN9"/>
        </source>
    </evidence>
    <sequence length="444" mass="49422" checksum="5245CAE51650D202" modified="2012-03-21" version="1">MMKLVLLILGLLIASTSAQIRTKGGTLIAKEGESLTLRCEVEDPSVAIIWRKNTEVVAVDDEILDTYGGYEISMEGSTSVLTIKRVEPINSANYSCALAEPEVSVTFVIKVQVKPLVVISPDTGVYHARVGEKNLVITCHVKEGNPKPGVVWTKQAAKLPEDIKREHGGARIVITEVKKHHAGKYNCLAENIAGSDRATIDIHVAEPLQGEREEKPWVKNEDTFIPVRKNQNASFWCTYDGTPVPQVEWLFNGYKINFNDEKFKKTSETAQRLNGYSKSTLTVGDISEEAFGDYACRISNKLGSVTAVVHVSGRPGPPQLSFDESELTWTVRAFDKILEYQLCHRLENADHFLPEDCNSVRVKKSDNNGDDKWTHTIDLSTFLEHGNKYHVQLKARNALGWGSMAKDALHVELQRIEKEEAKGASIISIISSILVTLVTMYLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZQ3</accession>
    <name>H2KZQ3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">slc-17.6</name>
        <name evidence="7" type="ORF">CELE_F12B6.2</name>
        <name evidence="9" type="ORF">F12B6.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD69302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_740804.1">
        <property type="nucleotide sequence ID" value="NM_171833.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZQ3"/>
    <dbReference type="SMR" id="H2KZQ3"/>
    <dbReference type="GeneID" id="171781"/>
    <dbReference type="AGR" id="WB:WBGene00017398"/>
    <dbReference type="CTD" id="171781"/>
    <dbReference type="WormBase" id="F12B6.2c">
        <property type="protein sequence ID" value="CE30513"/>
        <property type="gene ID" value="WBGene00017398"/>
        <property type="gene designation" value="slc-17.6"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017398">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZQ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000355">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF442">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD69302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F12B6.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZQ3"/>
        </source>
    </evidence>
    <sequence length="504" mass="55441" checksum="6AAAC043320D907F" modified="2012-03-21" version="1">MPSSTYNSVRSLPSPIPPLWTLQSIRFQTALLISAACVVFGLMRTCFGMAMVDIVRRLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFEGWPLVFIVYGLIGAVFLVIWHVRLADKPRESKYITATELTYIKGGKQRRNRAETIVRATPYMKIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNATAVTKVSNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLAPIVIGRITSHGTIYEWKCAFYSLAGVLAVTGLIFQIFGHGRTEPWGETPSNATSARLSTSVTMCEDGMCKLTLLEKHNHEFRTESKISSGSGNLKKKVSRVSYAGEEIVIPGRIEDLENDVIYSIEEERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZQ7</accession>
    <name>H2KZQ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">exp-2</name>
        <name evidence="16" type="ORF">CELE_F12F3.1</name>
        <name evidence="18" type="ORF">F12F3.1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD69346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023792.1">
        <property type="nucleotide sequence ID" value="NM_001028621.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZQ7"/>
    <dbReference type="SMR" id="H2KZQ7"/>
    <dbReference type="GeneID" id="179003"/>
    <dbReference type="KEGG" id="cel:CELE_F12F3.1"/>
    <dbReference type="AGR" id="WB:WBGene00001374"/>
    <dbReference type="CTD" id="179003"/>
    <dbReference type="WormBase" id="F12F3.1d">
        <property type="protein sequence ID" value="CE37631"/>
        <property type="gene ID" value="WBGene00001374"/>
        <property type="gene designation" value="exp-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001374">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZQ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000070">
        <property type="entry name" value="K+ channel tetramerization domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000187">
        <property type="entry name" value="Protein CBR-EXP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF133">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="15">
        <location>
            <begin position="70"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="218"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD69346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="F12F3.1d"/>
        </source>
    </evidence>
    <sequence length="501" mass="56678" checksum="919EF264720BA665" modified="2012-03-21" version="1">MKMAQARVTGNMISGAAQQHKKRLVPLRRTDAMTVAERRNYQILDDIFRSGASDCFQQVSSADNGSPQFLKLNIGGTSFMILIDAILRADTTTFLSRFVQLTHTARLKVADAYISADDAYYFQRSPTSFEAVFQYYATGVVHRPSEICPASFLSELDFWRISHQHVGSCCADIIPQKREEEKEEEKVDDTTFDKLMCGKLRRRMWTFLERPGSSMQAKAFELSSTLFVAISVMGLSFGTIPDFQVTHLMPPHNETVVLPNGTVTVVQKVEQMRVEHPAFVFTERICIAFFTVEYCLRFFAAPRKLRFALKPLNLVDLLAIVPFYLELLLTLCGVDDRKLRDLRWAFLVVRILRVLRVIRIIKLGRFSSGLQTFGMTLQRSQKQLQMMTIVLLTGVVFFSTMIYFLEKDEEGTPFTSIPAAYWWCIVTMTTVGYGDAVPATTMGKIIASAAIMCGVLVLALPITIIVDNFIKVAQDEQQAEQQKNDQQSEQLALEAMLNAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZQ9</accession>
    <name>H2KZQ9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sec-16a.2</name>
        <name evidence="10" type="synonym">sec-16A.2</name>
        <name evidence="10" type="ORF">CELE_F13B9.1</name>
        <name evidence="12" type="ORF">F13B9.1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024557.1">
        <property type="nucleotide sequence ID" value="NM_001029386.5"/>
    </dbReference>
    <dbReference type="GeneID" id="181084"/>
    <dbReference type="KEGG" id="cel:CELE_F13B9.1"/>
    <dbReference type="AGR" id="WB:WBGene00017419"/>
    <dbReference type="CTD" id="181084"/>
    <dbReference type="WormBase" id="F13B9.1c">
        <property type="protein sequence ID" value="CE35469"/>
        <property type="gene ID" value="WBGene00017419"/>
        <property type="gene designation" value="sec-16A.2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017419">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZQ9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000013">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF30">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="859"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="601"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1512"/>
            <end position="1609"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <end position="27"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1374"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1423"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1440"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1472"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1519"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1540"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1593"/>
            <end position="1609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD69408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F13B9.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZQ9"/>
        </source>
    </evidence>
    <sequence length="1609" mass="179275" checksum="FC9633C37FE5465B" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZR2</accession>
    <name>H2KZR2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuropeptide-Like Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F13C5.3</name>
        <name evidence="2 4" type="ORF">F13C5.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508126.2">
        <property type="nucleotide sequence ID" value="NM_075725.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZR2"/>
    <dbReference type="GeneID" id="184411"/>
    <dbReference type="AGR" id="WB:WBGene00017424"/>
    <dbReference type="CTD" id="184411"/>
    <dbReference type="WormBase" id="F13C5.3b">
        <property type="protein sequence ID" value="CE40326"/>
        <property type="gene ID" value="WBGene00017424"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2742356_0_0_1"/>
    <dbReference type="OrthoDB" id="5827120at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017424">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZR2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564358" evidence="1">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD69432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F13C5.3b"/>
        </source>
    </evidence>
    <sequence length="71" mass="8472" checksum="830B5AFF766864C2" modified="2012-03-21" version="1">MIFCRLILVFLFQISCSKKINFDKVYKDAMYASFLKSEFNYTSFLRRADHSAERYVPFQDTSNDTFFKVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZR6</accession>
    <name>H2KZR6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">bcl-11</name>
        <name evidence="16" type="ORF">CELE_F13H6.1</name>
        <name evidence="18" type="ORF">F13H6.1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <sequence length="431" mass="47951" checksum="FABD32DF8BC25BC9" modified="2012-03-21" version="1">MEGSRRRLSLPQAPMATPSNPAGALNGYPFASSRPHYERRQLPAMQHTLRHNHSMGSLMGPRELPFTHGYHHNPHARLSQPDIHSAIYRPHHYYSPPVYPGSHYHGLSTSQHSSPLYQRRMLPTPKNSGGIARKLLKRCTNPDLMRLQRTTEIREQSVGRTSCESAIVDPVYLALKQATGRYSRRGSTTFESASPSPRNLSQVSLQDSGYVEMGSSKANPLLGSTPQLDNAGRSVGRRRAPKLTQQMKSLSLDCQDMPPRINQNTRSPLISGSKLAPRDYRKPGINGSSDFSDVERSCSPIVKSRRSSSSALHAGGYIVIHEYSPSNGSSLVLGEKVRVVDNGDPDWLHGFRLNDRTEHMISFPATCVAQMMAGEQAMRIQQNVFVAEQKLRMYRDQIVFVQPESLVEGKVTVRTEHNALAPCPLSYLALI</sequence>
</entry>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
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        <source>
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    <sequence length="1216" mass="136950" checksum="82FAC08A240C7CD9" modified="2012-03-21" version="1"> </sequence>
</entry>
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    <accession>H2KZT8</accession>
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            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="WBGene00017900"/>
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        <location>
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            <begin position="676"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="824"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="952"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD69730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F28E10.1d"/>
        </source>
    </evidence>
    <sequence length="1264" mass="142070" checksum="424BEC8C1F9B3B84" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZT9</accession>
    <name>H2KZT9_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">Serine incorporator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_Y57E12AL.1</name>
        <name evidence="7 9" type="ORF">Y57E12AL.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD69747.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZT9"/>
    <dbReference type="SMR" id="H2KZT9"/>
    <dbReference type="PeptideAtlas" id="H2KZT9"/>
    <dbReference type="AGR" id="WB:WBGene00021956"/>
    <dbReference type="WormBase" id="Y57E12AL.1b">
        <property type="protein sequence ID" value="CE52440"/>
        <property type="gene ID" value="WBGene00021956"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021956">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZT9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD69747.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y57E12AL.1b"/>
        </source>
    </evidence>
    <sequence length="453" mass="49475" checksum="DE071BFECB142DB7" modified="2018-02-28" version="2">MGALLAAPACAASSACCFGSAACSLCCSICPTTKSSTTTRIMYAFLLFTSTFLSCIMLLPGIQNKLAENKWFCEGLNEYAGISCAHATGFQAVYRVCAATASFYLLFMLIMIGVKDSKDGRSSIQNGFWFFKYLILGALIVGFFFIRSESLATPLMYIGLIGGFMFILIQLILIVDFAHGLAEAWVTSYEESESNYCYAGLLVTVFGGFALALTAVIIMYIYYASGEGCGLPRFFVIFNTLLCVGLTALSLAPAVQEVSPRSGLVQAVMITGYVMYLTWAALINNPDKACNPSLISIFTGNSTDPSHKTDEGHYGIPLPAQSIVSLFLWFACLLYASIRNSSNTSLGKITGGGNTSDEAIQLTDDAESQNSKRVYDNEEEGVAYSYSFFHFMFALASLYVMMTLTSWYKPSNDLSHLNSNMASVWVKIVSSWVCVALYCWTLVAPIIYPDREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2P8</accession>
    <name>H9G2P8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium-dependent high-affinity dicarboxylate transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">nac-2</name>
        <name evidence="8" type="ORF">CELE_R107.1</name>
        <name evidence="10" type="ORF">R107.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCG28236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254976.1">
        <property type="nucleotide sequence ID" value="NM_001268047.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2P8"/>
    <dbReference type="SMR" id="H9G2P8"/>
    <dbReference type="GeneID" id="187898"/>
    <dbReference type="AGR" id="WB:WBGene00003518"/>
    <dbReference type="CTD" id="187898"/>
    <dbReference type="WormBase" id="R107.1b">
        <property type="protein sequence ID" value="CE47161"/>
        <property type="gene ID" value="WBGene00003518"/>
        <property type="gene designation" value="nac-2"/>
    </dbReference>
    <dbReference type="OMA" id="NMNTWTY"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="PhylomeDB" id="H9G2P8"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003518">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2P8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015746">
        <property type="term" value="P:citrate transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015744">
        <property type="term" value="P:succinate transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF84">
        <property type="entry name" value="SODIUM-DEPENDENT HIGH-AFFINITY DICARBOXYLATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCG28236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="R107.1b"/>
        </source>
    </evidence>
    <sequence length="585" mass="64975" checksum="71CB9EAFBC95A2BD" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2Q0</accession>
    <name>H9G2Q0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">npax-4</name>
        <name evidence="3" type="ORF">C09G9.7</name>
        <name evidence="1" type="ORF">CELE_C09G9.7</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255345.1">
        <property type="nucleotide sequence ID" value="NM_001268416.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2Q0"/>
    <dbReference type="GeneID" id="182466"/>
    <dbReference type="KEGG" id="cel:CELE_C09G9.7"/>
    <dbReference type="AGR" id="WB:WBGene00007496"/>
    <dbReference type="CTD" id="182466"/>
    <dbReference type="WormBase" id="C09G9.7b">
        <property type="protein sequence ID" value="CE47237"/>
        <property type="gene ID" value="WBGene00007496"/>
        <property type="gene designation" value="npax-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3280013_0_0_1"/>
    <dbReference type="OrthoDB" id="9996331at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007496">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2Q0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
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        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
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    </comment>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
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</entry>
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            <dbReference type="ChEBI" id="CHEBI:29103"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCG28124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2R8"/>
    <dbReference type="PeptideAtlas" id="H9G2R8"/>
    <dbReference type="AGR" id="WB:WBGene00008572"/>
    <dbReference type="WormBase" id="F08B12.4d">
        <property type="protein sequence ID" value="CE47417"/>
        <property type="gene ID" value="WBGene00008572"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160206_1_0_1"/>
    <dbReference type="OrthoDB" id="5852690at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008572">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2R8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003619610" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F08B12.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2R8"/>
        </source>
    </evidence>
    <sequence length="77" mass="8327" checksum="F4535B65C9F0DC76" modified="2012-05-16" version="1">MNSFVILAIVLAIVNAMPVEQDGLTGGRGVPHPNSAAGQELTNKNLEEKSVLEGGTQVKPWLKNQPDLANIREQNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2R9</accession>
    <name>H9G2R9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F08B12.4</name>
        <name evidence="3 5" type="ORF">F08B12.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCG28125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257150.1">
        <property type="nucleotide sequence ID" value="NM_001270221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2R9"/>
    <dbReference type="PeptideAtlas" id="H9G2R9"/>
    <dbReference type="GeneID" id="181333"/>
    <dbReference type="KEGG" id="cel:CELE_F08B12.4"/>
    <dbReference type="AGR" id="WB:WBGene00008572"/>
    <dbReference type="CTD" id="181333"/>
    <dbReference type="WormBase" id="F08B12.4f">
        <property type="protein sequence ID" value="CE47252"/>
        <property type="gene ID" value="WBGene00008572"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852690at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008572">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2R9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003620135" evidence="2">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F08B12.4f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2R9"/>
        </source>
    </evidence>
    <sequence length="97" mass="10132" checksum="9A43AD65DDE867BA" modified="2012-05-16" version="1">MNSFVILAIVLAIVNAMPVEQDGLTGGRGVPHPNSAAGQALSGKTGGSSVPHPNSAAGQELTNKNLEEKSVLEGGTQVKPWLKNQPDLANIREQNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2S0</accession>
    <name>H9G2S0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F08B12.4</name>
        <name evidence="2 4" type="ORF">F08B12.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCG28126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2S0"/>
    <dbReference type="SMR" id="H9G2S0"/>
    <dbReference type="PeptideAtlas" id="H9G2S0"/>
    <dbReference type="AGR" id="WB:WBGene00008572"/>
    <dbReference type="WormBase" id="F08B12.4i">
        <property type="protein sequence ID" value="CE47451"/>
        <property type="gene ID" value="WBGene00008572"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852690at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008572">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2S0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F08B12.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2S0"/>
        </source>
    </evidence>
    <sequence length="81" mass="8462" checksum="BC115B0CC397A2D3" modified="2012-05-16" version="1">MPVEQDGLTGGRGVPHPNSAAGQALSGKTGGSSVPHPNSAAGQELTNKNLEEKSVLEGGTQVKPWLKNQPDLANIREQNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H9G304</accession>
    <name>H9G304_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuropeptide-Like Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F46F3.3</name>
        <name evidence="2 4" type="ORF">F46F3.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256351.1">
        <property type="nucleotide sequence ID" value="NM_001269422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G304"/>
    <dbReference type="GeneID" id="185854"/>
    <dbReference type="AGR" id="WB:WBGene00009791"/>
    <dbReference type="CTD" id="185854"/>
    <dbReference type="WormBase" id="F46F3.3c">
        <property type="protein sequence ID" value="CE47125"/>
        <property type="gene ID" value="WBGene00009791"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5850842at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009791">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G304">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003619623" evidence="1">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F46F3.3c"/>
        </source>
    </evidence>
    <sequence length="154" mass="16879" checksum="BC05BEB1A96D0C25" modified="2012-05-16" version="1">MRIIISAFSILAISSVIESETTNESLMKMVDNEWMDKFIPREYKRTHSLSGSDEQDVTKDNNFGYSEQGMKDLDEVGGLVGGGDSDLLGILRPYYSMVEMTANGNKQGMGQYLHVLPDSSEGDTPIYSVGGSMYGGVEPAGAKLGYMNRPFGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>H9G305</accession>
    <name>H9G305_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kelch domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F53E4.1</name>
        <name evidence="1 3" type="ORF">F53E4.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256679.1">
        <property type="nucleotide sequence ID" value="NM_001269750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G305"/>
    <dbReference type="SMR" id="H9G305"/>
    <dbReference type="GeneID" id="180050"/>
    <dbReference type="AGR" id="WB:WBGene00009978"/>
    <dbReference type="CTD" id="180050"/>
    <dbReference type="WormBase" id="F53E4.1c">
        <property type="protein sequence ID" value="CE47077"/>
        <property type="gene ID" value="WBGene00009978"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045453_0_0_1"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009978">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G305">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000150">
        <property type="entry name" value="Protein CBG04780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052637">
        <property type="entry name" value="KLHDC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F53E4.1c"/>
        </source>
    </evidence>
    <sequence length="188" mass="20768" checksum="7BEC146D76654171" modified="2012-05-16" version="1">MALNLATGAWTRTKVPENTMKPGGRRSHSTWVYDGKMYMFGGYLGTINVHYNELYCFDPKTSMWSVISVRGTYPSARRRHCSVVSNGKVYLFGGTMPLPCHPLSTTNYNGMISPSGLADLSDLHVLDFAPSLKTLAMQSVLNELKVPSKGMFETLQNELAADIRFEMYCQVMPNVVSNGGSPRNDQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H9G308</accession>
    <name>H9G308_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHK kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nhr-246</name>
        <name evidence="2" type="ORF">CELE_ZK1037.4</name>
        <name evidence="4" type="ORF">ZK1037.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256662.1">
        <property type="nucleotide sequence ID" value="NM_001269733.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G308"/>
    <dbReference type="PeptideAtlas" id="H9G308"/>
    <dbReference type="GeneID" id="191499"/>
    <dbReference type="AGR" id="WB:WBGene00014192"/>
    <dbReference type="CTD" id="191499"/>
    <dbReference type="WormBase" id="ZK1037.4b">
        <property type="protein sequence ID" value="CE47102"/>
        <property type="gene ID" value="WBGene00014192"/>
        <property type="gene designation" value="nhr-246"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873804at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014192">
        <property type="expression patterns" value="Expressed in embryo"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G308">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF20">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="100"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZK1037.4b"/>
        </source>
    </evidence>
    <sequence length="352" mass="40245" checksum="66DCD9A9083B2D9D" modified="2012-05-16" version="1">MSDFLIENIPLTKEWLAELIEIKIGVKPKIGTIPQNTKGCSVVENAGGGVKNVDHSVVERFMHNTECNYYKLFSSLSEKPLQIPTTYLASKAGEKAPVPVIVLEMLEDCKLHDLIPGFNEDQLFKIVDELVKLHIFSLTTEKWKEIVPDESKLAMSGFLQCMVADVGRKLAQNPELGVILSYVENTLDTDPNYLQKMRDEYINEERPSVICHGDLWAPQILWDKEDNIAGIVDWQATHRGSPMEDLHHILSTCTSVQNRKTFTKPLLDHYYNKLKVGLKEKGFKTTWTREEIDIEYNYSFIYGASRTIFANGFWANSPVLQTDGKPDPERIKESFVRCKSYLEDTIRELNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H9G310</accession>
    <name>H9G310_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CUB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_K10D11.3</name>
        <name evidence="5 7" type="ORF">K10D11.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255692.1">
        <property type="nucleotide sequence ID" value="NM_001268763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G310"/>
    <dbReference type="PeptideAtlas" id="H9G310"/>
    <dbReference type="GeneID" id="187268"/>
    <dbReference type="AGR" id="WB:WBGene00010747"/>
    <dbReference type="CTD" id="187268"/>
    <dbReference type="WormBase" id="K10D11.3b">
        <property type="protein sequence ID" value="CE47114"/>
        <property type="gene ID" value="WBGene00010747"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5788354at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010747">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G310">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003366">
        <property type="entry name" value="CUB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056013">
        <property type="entry name" value="DUF7591"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056014">
        <property type="entry name" value="DUF7592"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47920:SF1">
        <property type="entry name" value="CUB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47920">
        <property type="entry name" value="PROTEIN CBG13378-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02408">
        <property type="entry name" value="CUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24511">
        <property type="entry name" value="DUF7591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24512">
        <property type="entry name" value="DUF7592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003619617" evidence="1">
        <location>
            <begin position="17"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="CUB-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7592" evidence="4">
        <location>
            <begin position="149"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7591" evidence="3">
        <location>
            <begin position="245"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCG28077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="K10D11.3b"/>
        </source>
    </evidence>
    <sequence length="492" mass="55416" checksum="1840BDBADF63CBEB" modified="2012-05-16" version="1">MYKLFLLLVIIKFSSSFDTSHFVCERDNQGPIWYDVPFYYPYTWNQNLDPPVYAPNQMCTWTISNPMGLYAIFTMKAYIGGDNSLMIADCNGNTEVIMTSDLQPYVFVGNKFTINLIVGANGNSTKFGFVVQWSPFPTPNPVFYHVNKTSPALFFDEMLYENSVTITAETRATIVAFPSTYPDFTPLLRITLVFDGPDLNSPYLGTLFQALRSNKPMVSNSKQMTVFTFQENYIVGSNFVVQDYYNVQSLSATKGVTCWSDTSCPVTLNAAKGPVSAMTLNPDDGKQYVKQLALSPNSVLKIYNGARREGDDSNLITTYNCEQSKTSIPQKFYGTIVTYYLANGTALVELAEDSNFTRWNDASDGRQGFISSRRYGKLDFFQDVKEEIGGLDSNQTFSFEINVIRLDVSNSAELVISFKNATGEDVHKFSKENNYQSRVFQGIGRNMTVQYNSNGEETSGFYLHFKIEAHNGCPGNYFTMTAFLLLFLPLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>H9G311</accession>
    <name>H9G311_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CUB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_K10D11.3</name>
        <name evidence="5 7" type="ORF">K10D11.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255691.1">
        <property type="nucleotide sequence ID" value="NM_001268762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G311"/>
    <dbReference type="GeneID" id="187268"/>
    <dbReference type="KEGG" id="cel:CELE_K10D11.3"/>
    <dbReference type="AGR" id="WB:WBGene00010747"/>
    <dbReference type="CTD" id="187268"/>
    <dbReference type="WormBase" id="K10D11.3a">
        <property type="protein sequence ID" value="CE47223"/>
        <property type="gene ID" value="WBGene00010747"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025754_0_0_1"/>
    <dbReference type="OrthoDB" id="5788354at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010747">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G311">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003366">
        <property type="entry name" value="CUB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056013">
        <property type="entry name" value="DUF7591"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056014">
        <property type="entry name" value="DUF7592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47920:SF1">
        <property type="entry name" value="CUB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47920">
        <property type="entry name" value="PROTEIN CBG13378-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02408">
        <property type="entry name" value="CUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24511">
        <property type="entry name" value="DUF7591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24512">
        <property type="entry name" value="DUF7592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003620739" evidence="1">
        <location>
            <begin position="17"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="CUB-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7592" evidence="4">
        <location>
            <begin position="159"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7591" evidence="3">
        <location>
            <begin position="255"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCG28078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="K10D11.3a"/>
        </source>
    </evidence>
    <sequence length="502" mass="56807" checksum="D90B29AB9230D0BD" modified="2012-05-16" version="1">MIWLVFFSFILKLISAFNGEDIFVLCPTQDTQFPTKNNNSSTDQYNPYYYPYPWWPNSYIPRYKSNQFCKWTVVIPDRTFINFTMIADIADDSALMITDSNGNQENIMTSDLQPYVFVGNKFTINLIVGANGNSTKFGFVVQWSPFPTPNPVFYHVNKTSPALFFDEMLYENSVTITAETRATIVAFPSTYPDFTPLLRITLVFDGPDLNSPYLGTLFQALRSNKPMVSNSKQMTVFTFQENYIVGSNFVVQDYYNVQSLSATKGVTCWSDTSCPVTLNAAKGPVSAMTLNPDDGKQYVKQLALSPNSVLKIYNGARREGDDSNLITTYNCEQSKTSIPQKFYGTIVTYYLANGTALVELAEDSNFTRWNDASDGRQGFISSRRYGKLDFFQDVKEEIGGLDSNQTFSFEINVIRLDVSNSAELVISFKNATGEDVHKFSKENNYQSRVFQGIGRNMTVQYNSNGEETSGFYLHFKIEAHNGCPGNYFTMTAFLLLFLPLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H9G313</accession>
    <name>H9G313_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C25F9.14</name>
        <name evidence="1" type="ORF">CELE_C25F9.14</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256857.1">
        <property type="nucleotide sequence ID" value="NM_001269928.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G313"/>
    <dbReference type="GeneID" id="6418699"/>
    <dbReference type="AGR" id="WB:WBGene00045461"/>
    <dbReference type="CTD" id="6418699"/>
    <dbReference type="WormBase" id="C25F9.14b">
        <property type="protein sequence ID" value="CE47111"/>
        <property type="gene ID" value="WBGene00045461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00045461">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G313">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21516:SF4">
        <property type="entry name" value="AAA_LID_7 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21516">
        <property type="entry name" value="AAA_LID_7 DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C25F9.14b"/>
        </source>
    </evidence>
    <sequence length="144" mass="16718" checksum="1A9B0C144F2016DC" modified="2012-05-16" version="1">MIMLSHQHEQIVYDFDVFLTKAKEMSEQDPPDIVIFSNLIWGQHAQEKLREIVLDTSTDDAIVCESLYSAWTFAKHCRKNAMRYINKELRNEILLSVADMEAYMNATDIEKIKEKIPTSGLQIKHSQNNVKIGNCQFSYNKVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>H9G317</accession>
    <name>H9G317_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Follistatin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F46B3.14</name>
        <name evidence="3 5" type="ORF">F46B3.14</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256937.1">
        <property type="nucleotide sequence ID" value="NM_001270008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G317"/>
    <dbReference type="GeneID" id="185836"/>
    <dbReference type="AGR" id="WB:WBGene00009765"/>
    <dbReference type="CTD" id="185836"/>
    <dbReference type="WormBase" id="F46B3.14a">
        <property type="protein sequence ID" value="CE47385"/>
        <property type="gene ID" value="WBGene00009765"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1604227_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009765">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G317">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013356866" evidence="1">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Follistatin-like" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Follistatin-like" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F46B3.14a"/>
        </source>
    </evidence>
    <sequence length="166" mass="17254" checksum="7093605DD55A3AFD" modified="2012-05-16" version="1">MKYILCLLLAGGISARVAPIESIVGPGAPCIGEECGDNLSNPCSLIKCSNGSHCVPRGTTGRCVLDSNPCASIKCGRGYHCAVENGQGGCVPNVPSEVDLCSLVKCALGGHCENGNCVPAFWREIRCLVLARYSALGICSLLSSAQHVFGFLCVRQAAIVALKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H9G318</accession>
    <name>H9G318_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Follistatin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F46B3.14</name>
        <name evidence="3 5" type="ORF">F46B3.14</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256936.1">
        <property type="nucleotide sequence ID" value="NM_001270007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G318"/>
    <dbReference type="SMR" id="H9G318"/>
    <dbReference type="GeneID" id="185836"/>
    <dbReference type="AGR" id="WB:WBGene00009765"/>
    <dbReference type="CTD" id="185836"/>
    <dbReference type="WormBase" id="F46B3.14b">
        <property type="protein sequence ID" value="CE47260"/>
        <property type="gene ID" value="WBGene00009765"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1751359_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009765">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G318">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012632946" evidence="1">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Follistatin-like" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Follistatin-like" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Follistatin-like" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F46B3.14b"/>
        </source>
    </evidence>
    <sequence length="158" mass="16051" checksum="35A6BF6A4DF3B1E6" modified="2012-05-16" version="1">MKYILCLLLAGGISARVAPIESIVGPGAPCIGEECGDNLSNPCSLIKCSNGSHCVPRGTTGRCVLDSNPCASIKCGRGYHCAVENGQGGCVPNVPSEVDLCSLVKCALGGHCENGNCVPDGIPINPCQLIQCPAGQKCVFGNKPATCVPDVAFSVGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H9G321</accession>
    <name>H9G321_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_R13H4.2</name>
        <name evidence="1 3" type="ORF">R13H4.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256378.1">
        <property type="nucleotide sequence ID" value="NM_001269449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G321"/>
    <dbReference type="PeptideAtlas" id="H9G321"/>
    <dbReference type="GeneID" id="6418761"/>
    <dbReference type="AGR" id="WB:WBGene00014826"/>
    <dbReference type="CTD" id="6418761"/>
    <dbReference type="WormBase" id="R13H4.2c">
        <property type="protein sequence ID" value="CE12802"/>
        <property type="gene ID" value="WBGene00014826"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109079_0_0_1"/>
    <dbReference type="OrthoDB" id="5839780at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014826">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G321">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="R13H4.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H9G321"/>
        </source>
    </evidence>
    <sequence length="221" mass="27736" checksum="A9385AD50343252F" modified="2012-05-16" version="1">MTDYALVRSRSALVRSRSVEPSSRLYVTRTSSVPDLTAHFRYSDKYRPQWHTVYQSTPYRWRRDWDLYDDYWYDKYYYFSPLYRSTYYPSRRYSYSDYLPNPYYWNNYGSYWTRYKGYWYDYDYPSSYRRYTDSAFNRYLNYTYTPYRSYLMDSLSTSLSRGLSMYKAGLINHTTLDAYWLTPKYWDRRFKNWRELYCSTKDNYLPSTYDRKTRQYFAQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>H9G336</accession>
    <name>H9G336_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Papilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">mlt-11</name>
        <name evidence="9" type="ORF">CELE_W01F3.3</name>
        <name evidence="11" type="ORF">W01F3.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256943.1">
        <property type="nucleotide sequence ID" value="NM_001270014.3"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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        </source>
    </evidence>
    <sequence length="277" mass="30888" checksum="3EE1F980D54C02D8" modified="2012-05-16" version="1">MFFTFTLGMECLALFPFVLALFVRTKLPPTPPSASSAAHQNNIGFFKSILQCIFNAQFFIQMTLFAFAFSLLWSLMIFLDGPLKDQGYEMAGYPTAVCAIVGTLTSLLAGHIADKTRKFKEIIRVCTVGFSCSVITLRMFLNQPRTGLFDSIIVYTLCGCLGAFSIPQFPIGVELGVETTFPVMEATSSGVLVIFGSLFMFIIPFAQNYTEKLHLFYAQSWKFALDVTCGLSIVSVILSLFFLRPRYRRLELENAKLALENEEPVTARTAASDIEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H9G338</accession>
    <name>H9G338_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">grl-14</name>
        <name evidence="3" type="ORF">CELE_T03D8.4</name>
        <name evidence="5" type="ORF">T03D8.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256957.1">
        <property type="nucleotide sequence ID" value="NM_001270028.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G338"/>
    <dbReference type="GeneID" id="188013"/>
    <dbReference type="AGR" id="WB:WBGene00001723"/>
    <dbReference type="CTD" id="188013"/>
    <dbReference type="WormBase" id="T03D8.4c">
        <property type="protein sequence ID" value="CE47112"/>
        <property type="gene ID" value="WBGene00001723"/>
        <property type="gene designation" value="grl-14"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726135_0_0_1"/>
    <dbReference type="OrthoDB" id="5775991at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G338">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003619628" evidence="1">
        <location>
            <begin position="20"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="2">
        <location>
            <begin position="343"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T03D8.4c"/>
        </source>
    </evidence>
    <sequence length="438" mass="49194" checksum="A5DAE05854965175" modified="2012-05-16" version="1">MILILITLVFVFQKTQISAKSDFEILKNDSIFDGGTQGNKAFLKTQLLRNLNNFYPSINNGEKLEMLTGRKPEFEDDRERNQNFDGNSVTEPFPTQYPTLIPYARESNPEEELQLATAPTSKIRSEGRITSEQKMDSIRDFRMKLYKAFKNRPKLSRMIRKINDVVEMNDGFPTIMDKNRQIILSRTEPNWQSLNTRKPNQTYGRDQNGNLIPLLGLEPAANFVDTKQGSPIEPYPPREIRYAYRTTNRQPVVYVPSASPVNQPSHASNTVPVAVASYLVTANPSSQPIQLHILPPIPSPQPQIIYQQTTPSSQFVAYSTFAPPIEPSNECGNGQCKPESDEDKCNSQRLRDIIFNNIVSGDAEASKRAVQSAAEAETGLFFDAICGTGFFSYIAHTDEFCLASSGGVNCYVFAPICQIDSQNQQKRTSKKLVKLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H9G339</accession>
    <name>H9G339_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">grl-14</name>
        <name evidence="3" type="ORF">CELE_T03D8.4</name>
        <name evidence="5" type="ORF">T03D8.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256956.1">
        <property type="nucleotide sequence ID" value="NM_001270027.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G339"/>
    <dbReference type="GeneID" id="188013"/>
    <dbReference type="AGR" id="WB:WBGene00001723"/>
    <dbReference type="CTD" id="188013"/>
    <dbReference type="WormBase" id="T03D8.4b">
        <property type="protein sequence ID" value="CE47182"/>
        <property type="gene ID" value="WBGene00001723"/>
        <property type="gene designation" value="grl-14"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5775991at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G339">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003620154" evidence="1">
        <location>
            <begin position="20"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="2">
        <location>
            <begin position="343"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T03D8.4b"/>
        </source>
    </evidence>
    <sequence length="438" mass="49180" checksum="E644C623B62603DB" modified="2012-05-16" version="1">MILILITLVFVFQKTQISAKSDFEILKNDSIFDGGTQGNKAFLKTQLLRNLNNFYPSINNGEKLEMLTGRKPEFEDDRERNQNFDGNSVTEPFPTQYPTLIPYARESNPEEELQLATAPTSKIRSEGRITSEQKMDSIRDFRMKLYKAFKNRPKLSRMIRKSNVNDVVEMNDGFPTIMDKNRQIILSRTEPNWQSLNTRKPNQTYGRDQNGNLIPLLGLEPAANFVDTKQGSPIEPYPPREIRYAYRTTNRQPVVYVPSASPVNQPSHASNTVPVAVASYLANPSSQPIQLHILPPIPSPQPQIIYQQTTPSSQFVAYSTFAPPIEPSNECGNGQCKPESDEDKCNSQRLRDIIFNNIVSGDAEASKRAVQSAAEAETGLFFDAICGTGFFSYIAHTDEFCLASSGGVNCYVFAPICQIDSQNQQKRTSKKLVKLSKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>O02058-2</accession>
    <name>PTPS_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Putative 6-pyruvoyl tetrahydrobiopterin synthase</fullName>
            <shortName>PTP synthase</shortName>
            <shortName>PTPS</shortName>
            <ecNumber>4.2.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ptps-1</name>
        <name type="ORF">B0041.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O02058-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_019291"/>
        </isoform>
        <isoform>
            <id>O02058-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="4.2.3.12"/>
    <dbReference type="RefSeq" id="NP_001040627.1">
        <property type="nucleotide sequence ID" value="NM_001047162.4"/>
    </dbReference>
    <dbReference type="WormBase" id="B0041.6b">
        <property type="protein sequence ID" value="CE39541"/>
        <property type="gene ID" value="WBGene00015010"/>
        <property type="gene designation" value="ptps-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="137" mass="15612" checksum="C5D18E885E24B16B" modified="2003-10-10" version="2">MPIVTMERVDSFSAAHRLHSEKLSDAENKETFGKCNNSNGHGHNYVWKVKLRGEVDPTSGMVYDLAKLKKEMSLVLDTVDHRNLDKDVEFFKTTVSTSENVAIYMFEKLKSVMSNPSVLYKVTIEETPKNIFTYKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>O62022</accession>
    <accession>O18293</accession>
    <name>O62022_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neogenin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_ZK131.11</name>
        <name evidence="3 5" type="ORF">ZK131.11</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAB05840.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T18801">
        <property type="entry name" value="T18801"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_496886.2">
        <property type="nucleotide sequence ID" value="NM_064485.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O62022"/>
    <dbReference type="SMR" id="O62022"/>
    <dbReference type="DIP" id="DIP-26458N"/>
    <dbReference type="GeneID" id="175024"/>
    <dbReference type="KEGG" id="cel:CELE_ZK131.11"/>
    <dbReference type="UCSC" id="ZK131.11b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013934"/>
    <dbReference type="CTD" id="175024"/>
    <dbReference type="WormBase" id="ZK131.11a">
        <property type="protein sequence ID" value="CE32036"/>
        <property type="gene ID" value="WBGene00013934"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_892056_0_0_1"/>
    <dbReference type="OrthoDB" id="5877602at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013934">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O62022">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004159084" evidence="2">
        <location>
            <begin position="24"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB05840.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="ZK131.11a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="O62022"/>
        </source>
    </evidence>
    <sequence length="337" mass="37564" checksum="7B9E79DBC3B16390" modified="2003-03-01" version="3">MFFILSLIDLWAWLVTFKDFSLAIVGASDSFNGNSTGGKSSEQPIQAAFLRKSRKDGGGLHLDDVSTSHHHNNHQQKGSRNLKYSQSSRRKYEQATTTTSGSSTDDSDRGSGSSSGSHHRSHSAGPHTTYSTTSNHAVSTTEMNRSGVRGGPNAESNTTFLRATKRFFKKIYTSATLPKKQNSTSMDNFQKSSVFFEDTAHHHNPNMDGRILKKAPLSTDENDYSNHLDDDYDDETMRSENATMDISYPDSGFEMDRASTPEQSSVSMTSTSKSGDDPVNFTNLFEQLKREMKEMRERDAQILSDLQRVETQIQSVKQAQILASLQDEFEPVESMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>O76676</accession>
    <name>O76676_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="ORF">C04E12.5</name>
        <name evidence="9" type="ORF">CELE_C04E12.5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
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        <property type="protein sequence ID" value="CCD62923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PIR" id="T33412">
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    <dbReference type="AlphaFoldDB" id="O76676"/>
    <dbReference type="SMR" id="O76676"/>
    <dbReference type="PaxDb" id="6239-C04E12.5"/>
    <dbReference type="GeneID" id="182210"/>
    <dbReference type="UCSC" id="C04E12.5">
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    <dbReference type="WormBase" id="C04E12.5a">
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    <dbReference type="PhylomeDB" id="O76676"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GO" id="GO:0006516">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="FunFam" id="2.60.120.1020:FF:000004">
        <property type="entry name" value="Uncharacterized protein"/>
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        <property type="entry name" value="Peptide N glycanase, PAW domain"/>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
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    <dbReference type="InterPro" id="IPR006588">
        <property type="entry name" value="Peptide_N_glycanase_PAW_dom"/>
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    <dbReference type="PANTHER" id="PTHR48440">
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    <dbReference type="PANTHER" id="PTHR48440:SF1">
        <property type="entry name" value="PAW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00613">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51398">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PAW" evidence="8">
        <location>
            <begin position="85"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PAW" evidence="8">
        <location>
            <begin position="290"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD62923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C04E12.5a"/>
        </source>
    </evidence>
    <sequence length="481" mass="54515" checksum="4CECDD49D5BB1627" modified="2003-10-01" version="2">MTSQNAPFLYSQIDPLLLSRTNRPQPRDRWKTIIKITTTFIGVLMVTTPIVFGLSGVAGNTSHFKNISSTTGKYPEKNSTDFDTSTTTVSEANTTFDTTESLYLAEEITTQEKLIQLNPNSGHNYVKFTYDILNNTYSHDNIDGSPVAPYFVDKIERVVDRKNNEAYLHQEFPDDFSNMYWAFSLKNDGKSVEKVVISIPGIEEIVNNRAGVVETCPNFLINCFNIPVEKSLTIEQQMDKLYISIMLQKDIKVLKTKLKGVSNVESFKIEVYWKNMTMDSPTTTTPGSIATTKSSTTTITETHHQPDISSTRLTEHQDIIQLTPKSGQDYAKFTYDVISNTYSQSNEDGSPVKPYLASNVEHVVDRRLNVAYIHMKEPINKRIGLINWEFDFRFPGRSVEKLEIKLTGMDEIVHNGGTANACLHDSFKCTAIPINGSLTIEKPQFNKFFMQIELFKDIKVFKTELNDRSSAESISIVVYWS</sequence>
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    <accession>P34314-2</accession>
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        <recommendedName>
            <fullName>Isoform a of Serine/threonine-protein kinase tousled-like 1</fullName>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Curr. Biol." volume="13" first="1921" last="1929">
            <title>The C. elegans Tousled-like kinase (TLK-1) has an essential role in transcription.</title>
            <authorList>
                <person name="Han Z."/>
                <person name="Saam J.R."/>
                <person name="Adams H.P."/>
                <person name="Mango S.E."/>
                <person name="Schumacher J.M."/>
            </authorList>
            <dbReference type="PubMed" id="14614817"/>
            <dbReference type="DOI" id="10.1016/j.cub.2003.10.035"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>AUTOPHOSPHORYLATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Curr. Biol." volume="15" first="894" last="904">
            <title>The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase.</title>
            <authorList>
                <person name="Han Z."/>
                <person name="Riefler G.M."/>
                <person name="Saam J.R."/>
                <person name="Mango S.E."/>
                <person name="Schumacher J.M."/>
            </authorList>
            <dbReference type="PubMed" id="15916946"/>
            <dbReference type="DOI" id="10.1016/j.cub.2005.04.019"/>
        </citation>
        <scope>INTERACTION WITH AIR-2</scope>
        <scope>PHOSPHORYLATION AT SER-634</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34314-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_011154"/>
        </isoform>
        <isoform>
            <id>P34314-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="RefSeq" id="NP_499145.2">
        <property type="nucleotide sequence ID" value="NM_066744.6"/>
    </dbReference>
    <dbReference type="WormBase" id="C07A9.3a">
        <property type="protein sequence ID" value="CE36353"/>
        <property type="gene ID" value="WBGene00006579"/>
        <property type="gene designation" value="tlk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="960" mass="108635" checksum="01280D2F8461CCD7" modified="2004-07-30" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>P34447-2</accession>
    <name>ZFP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform b of Zinc finger protein zfp-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein AF-10 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">zfp-1</name>
        <name evidence="3" type="ORF">F54F2.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Genome Biol." volume="7" first="R4.1" last="R4.10">
            <title>Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference.</title>
            <authorList>
                <person name="Lehner B."/>
                <person name="Calixto A."/>
                <person name="Crombie C."/>
                <person name="Tischler J."/>
                <person name="Fortunato A."/>
                <person name="Chalfie M."/>
                <person name="Fraser A.G."/>
            </authorList>
            <dbReference type="PubMed" id="16507136"/>
            <dbReference type="DOI" id="10.1186/gb-2006-7-1-r4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="PLoS Genet." volume="2" first="E74" last="E74">
            <title>Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.</title>
            <authorList>
                <person name="Cui M."/>
                <person name="Kim E.B."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="16710447"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.0020074"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002299" last="E1002299">
            <title>A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mansisidor A.R."/>
                <person name="Cecere G."/>
                <person name="Hoersch S."/>
                <person name="Jensen M.B."/>
                <person name="Kawli T."/>
                <person name="Kennedy L.M."/>
                <person name="Chavez V."/>
                <person name="Tan M.W."/>
                <person name="Lieb J.D."/>
                <person name="Grishok A."/>
            </authorList>
            <dbReference type="PubMed" id="21980302"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002299"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
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        <citation type="journal article" date="2013" name="Mol. Cell" volume="50" first="894" last="907">
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        <citation type="journal article" date="2013" name="Mol. Cell. Biol." volume="33" first="999" last="1015">
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        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E74908" last="E74908">
            <title>A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans.</title>
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                <person name="Gysi S."/>
                <person name="Rhiner C."/>
                <person name="Flibotte S."/>
                <person name="Moerman D.G."/>
                <person name="Hengartner M.O."/>
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        <scope>MUTAGENESIS OF 601-TRP--LYS-867</scope>
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    <reference key="9">
        <citation type="journal article" date="2014" name="Genetics" volume="197" first="207" last="220">
            <title>Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans.</title>
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                <person name="Kennedy L.M."/>
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    <reference key="10">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E113060" last="E113060">
            <title>The insulin/IGF signaling regulators cytohesin/GRP-1 and PIP5K/PPK-1 modulate susceptibility to excitotoxicity in C. elegans.</title>
            <authorList>
                <person name="Tehrani N."/>
                <person name="Del Rosario J."/>
                <person name="Dominguez M."/>
                <person name="Kalb R."/>
                <person name="Mano I."/>
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            <dbReference type="DOI" id="10.1371/journal.pone.0113060"/>
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        <citation type="journal article" date="2016" name="Aging Cell" volume="15" first="694" last="705">
            <title>A chromatin modifier integrates insulin/IGF-1 signalling and dietary restriction to regulate longevity.</title>
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                <person name="Singh A."/>
                <person name="Kumar N."/>
                <person name="Matai L."/>
                <person name="Jain V."/>
                <person name="Garg A."/>
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            <dbReference type="DOI" id="10.1111/acel.12477"/>
        </citation>
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        <scope>TISSUE SPECIFICITY (ISOFORMS A AND C)</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
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            </authorList>
            <dbReference type="PubMed" id="7906398"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain>Bristol N2</strain>
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    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Genome Biol." volume="7" first="R4.1" last="R4.10">
            <title>Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference.</title>
            <authorList>
                <person name="Lehner B."/>
                <person name="Calixto A."/>
                <person name="Crombie C."/>
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                <person name="Fortunato A."/>
                <person name="Chalfie M."/>
                <person name="Fraser A.G."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2006-7-1-r4"/>
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    <reference key="4">
        <citation type="journal article" date="2006" name="PLoS Genet." volume="2" first="E74" last="E74">
            <title>Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.</title>
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                <person name="Kim E.B."/>
                <person name="Han M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.0020074"/>
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    <reference key="5">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002299" last="E1002299">
            <title>A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mansisidor A.R."/>
                <person name="Cecere G."/>
                <person name="Hoersch S."/>
                <person name="Jensen M.B."/>
                <person name="Kawli T."/>
                <person name="Kennedy L.M."/>
                <person name="Chavez V."/>
                <person name="Tan M.W."/>
                <person name="Lieb J.D."/>
                <person name="Grishok A."/>
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            <dbReference type="PubMed" id="21980302"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002299"/>
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        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
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    <reference key="6">
        <citation type="journal article" date="2013" name="Mol. Cell" volume="50" first="894" last="907">
            <title>The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription.</title>
            <authorList>
                <person name="Cecere G."/>
                <person name="Hoersch S."/>
                <person name="Jensen M.B."/>
                <person name="Dixit S."/>
                <person name="Grishok A."/>
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        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>INTERACTION WITH DOT-1.1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2013" name="Mol. Cell. Biol." volume="33" first="999" last="1015">
            <title>The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans.</title>
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                <person name="Avgousti D.C."/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference key="8">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E74908" last="E74908">
            <title>A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gysi S."/>
                <person name="Rhiner C."/>
                <person name="Flibotte S."/>
                <person name="Moerman D.G."/>
                <person name="Hengartner M.O."/>
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        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 601-TRP--LYS-867</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2014" name="Genetics" volume="197" first="207" last="220">
            <title>Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kennedy L.M."/>
                <person name="Grishok A."/>
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    <reference key="10">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E113060" last="E113060">
            <title>The insulin/IGF signaling regulators cytohesin/GRP-1 and PIP5K/PPK-1 modulate susceptibility to excitotoxicity in C. elegans.</title>
            <authorList>
                <person name="Tehrani N."/>
                <person name="Del Rosario J."/>
                <person name="Dominguez M."/>
                <person name="Kalb R."/>
                <person name="Mano I."/>
            </authorList>
            <dbReference type="PubMed" id="25422944"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0113060"/>
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        <citation type="journal article" date="2016" name="Aging Cell" volume="15" first="694" last="705">
            <title>A chromatin modifier integrates insulin/IGF-1 signalling and dietary restriction to regulate longevity.</title>
            <authorList>
                <person name="Singh A."/>
                <person name="Kumar N."/>
                <person name="Matai L."/>
                <person name="Jain V."/>
                <person name="Garg A."/>
                <person name="Mukhopadhyay A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1111/acel.12477"/>
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        <scope>TISSUE SPECIFICITY (ISOFORMS A AND C)</scope>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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        <citation type="journal article" date="2001" name="Genes Dev." volume="15" first="789" last="802">
            <title>Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans.</title>
            <authorList>
                <person name="Wu J."/>
                <person name="Duggan A."/>
                <person name="Chalfie M."/>
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            <dbReference type="PubMed" id="11274062"/>
            <dbReference type="DOI" id="10.1101/gad.857401"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>MUTAGENESIS OF ALA-134 AND ARG-140</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Development" volume="130" first="5217" last="5227">
            <title>Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior.</title>
            <authorList>
                <person name="Yu H."/>
                <person name="Pretot R.F."/>
                <person name="Burglin T.R."/>
                <person name="Sternberg P.W."/>
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        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ALA-134</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Development" volume="140" first="3838" last="3847">
            <title>Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression.</title>
            <authorList>
                <person name="Feng G."/>
                <person name="Yi P."/>
                <person name="Yang Y."/>
                <person name="Chai Y."/>
                <person name="Tian D."/>
                <person name="Zhu Z."/>
                <person name="Liu J."/>
                <person name="Zhou F."/>
                <person name="Cheng Z."/>
                <person name="Wang X."/>
                <person name="Li W."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="23946438"/>
            <dbReference type="DOI" id="10.1242/dev.098723"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH EGL-46</scope>
        <scope>MUTAGENESIS OF ALA-91; ALA-134; ARG-140 AND ARG-145</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Exp. Cell Res." volume="319" first="931" last="945">
            <title>Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Iwasa H."/>
                <person name="Maimaiti S."/>
                <person name="Kuroyanagi H."/>
                <person name="Kawano S."/>
                <person name="Inami K."/>
                <person name="Timalsina S."/>
                <person name="Ikeda M."/>
                <person name="Nakagawa K."/>
                <person name="Hata Y."/>
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            <dbReference type="DOI" id="10.1016/j.yexcr.2013.01.020"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH YAP-1</scope>
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    <reference key="6">
        <citation type="journal article" date="2017" name="Dev. Biol." volume="432" first="248" last="257">
            <title>Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron.</title>
            <authorList>
                <person name="O'Brien B.M.J."/>
                <person name="Palumbos S.D."/>
                <person name="Novakovic M."/>
                <person name="Shang X."/>
                <person name="Sundararajan L."/>
                <person name="Miller D.M. III"/>
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            <dbReference type="DOI" id="10.1016/j.ydbio.2017.10.009"/>
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        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2018" name="Development" volume="145" first="0" last="0">
            <title>Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zheng C."/>
                <person name="Jin F.Q."/>
                <person name="Trippe B.L."/>
                <person name="Wu J."/>
                <person name="Chalfie M."/>
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            <dbReference type="DOI" id="10.1242/dev.168096"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH EGL-46</scope>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Genes Dev." volume="15" first="789" last="802">
            <title>Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans.</title>
            <authorList>
                <person name="Wu J."/>
                <person name="Duggan A."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="11274062"/>
            <dbReference type="DOI" id="10.1101/gad.857401"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>MUTAGENESIS OF ALA-134 AND ARG-140</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Development" volume="130" first="5217" last="5227">
            <title>Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior.</title>
            <authorList>
                <person name="Yu H."/>
                <person name="Pretot R.F."/>
                <person name="Burglin T.R."/>
                <person name="Sternberg P.W."/>
            </authorList>
            <dbReference type="PubMed" id="12954713"/>
            <dbReference type="DOI" id="10.1242/dev.00678"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ALA-134</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Development" volume="140" first="3838" last="3847">
            <title>Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression.</title>
            <authorList>
                <person name="Feng G."/>
                <person name="Yi P."/>
                <person name="Yang Y."/>
                <person name="Chai Y."/>
                <person name="Tian D."/>
                <person name="Zhu Z."/>
                <person name="Liu J."/>
                <person name="Zhou F."/>
                <person name="Cheng Z."/>
                <person name="Wang X."/>
                <person name="Li W."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="23946438"/>
            <dbReference type="DOI" id="10.1242/dev.098723"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH EGL-46</scope>
        <scope>MUTAGENESIS OF ALA-91; ALA-134; ARG-140 AND ARG-145</scope>
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    <reference key="5">
        <citation type="journal article" date="2013" name="Exp. Cell Res." volume="319" first="931" last="945">
            <title>Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.</title>
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                <person name="Iwasa H."/>
                <person name="Maimaiti S."/>
                <person name="Kuroyanagi H."/>
                <person name="Kawano S."/>
                <person name="Inami K."/>
                <person name="Timalsina S."/>
                <person name="Ikeda M."/>
                <person name="Nakagawa K."/>
                <person name="Hata Y."/>
            </authorList>
            <dbReference type="PubMed" id="23396260"/>
            <dbReference type="DOI" id="10.1016/j.yexcr.2013.01.020"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH YAP-1</scope>
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    <reference key="6">
        <citation type="journal article" date="2017" name="Dev. Biol." volume="432" first="248" last="257">
            <title>Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron.</title>
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                <person name="O'Brien B.M.J."/>
                <person name="Palumbos S.D."/>
                <person name="Novakovic M."/>
                <person name="Shang X."/>
                <person name="Sundararajan L."/>
                <person name="Miller D.M. III"/>
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            <dbReference type="DOI" id="10.1016/j.ydbio.2017.10.009"/>
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        <scope>FUNCTION</scope>
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    <reference key="7">
        <citation type="journal article" date="2018" name="Development" volume="145" first="0" last="0">
            <title>Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zheng C."/>
                <person name="Jin F.Q."/>
                <person name="Trippe B.L."/>
                <person name="Wu J."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="30291162"/>
            <dbReference type="DOI" id="10.1242/dev.168096"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH EGL-46</scope>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Genes Dev." volume="15" first="789" last="802">
            <title>Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans.</title>
            <authorList>
                <person name="Wu J."/>
                <person name="Duggan A."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="11274062"/>
            <dbReference type="DOI" id="10.1101/gad.857401"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>MUTAGENESIS OF ALA-134 AND ARG-140</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Development" volume="130" first="5217" last="5227">
            <title>Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior.</title>
            <authorList>
                <person name="Yu H."/>
                <person name="Pretot R.F."/>
                <person name="Burglin T.R."/>
                <person name="Sternberg P.W."/>
            </authorList>
            <dbReference type="PubMed" id="12954713"/>
            <dbReference type="DOI" id="10.1242/dev.00678"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ALA-134</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Development" volume="140" first="3838" last="3847">
            <title>Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression.</title>
            <authorList>
                <person name="Feng G."/>
                <person name="Yi P."/>
                <person name="Yang Y."/>
                <person name="Chai Y."/>
                <person name="Tian D."/>
                <person name="Zhu Z."/>
                <person name="Liu J."/>
                <person name="Zhou F."/>
                <person name="Cheng Z."/>
                <person name="Wang X."/>
                <person name="Li W."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="23946438"/>
            <dbReference type="DOI" id="10.1242/dev.098723"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH EGL-46</scope>
        <scope>MUTAGENESIS OF ALA-91; ALA-134; ARG-140 AND ARG-145</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Exp. Cell Res." volume="319" first="931" last="945">
            <title>Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.</title>
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                <person name="Iwasa H."/>
                <person name="Maimaiti S."/>
                <person name="Kuroyanagi H."/>
                <person name="Kawano S."/>
                <person name="Inami K."/>
                <person name="Timalsina S."/>
                <person name="Ikeda M."/>
                <person name="Nakagawa K."/>
                <person name="Hata Y."/>
            </authorList>
            <dbReference type="PubMed" id="23396260"/>
            <dbReference type="DOI" id="10.1016/j.yexcr.2013.01.020"/>
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        <scope>FUNCTION</scope>
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    <reference key="6">
        <citation type="journal article" date="2017" name="Dev. Biol." volume="432" first="248" last="257">
            <title>Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron.</title>
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                <person name="O'Brien B.M.J."/>
                <person name="Palumbos S.D."/>
                <person name="Novakovic M."/>
                <person name="Shang X."/>
                <person name="Sundararajan L."/>
                <person name="Miller D.M. III"/>
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            <dbReference type="DOI" id="10.1016/j.ydbio.2017.10.009"/>
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        <scope>FUNCTION</scope>
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    <reference key="7">
        <citation type="journal article" date="2018" name="Development" volume="145" first="0" last="0">
            <title>Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans.</title>
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                <person name="Zheng C."/>
                <person name="Jin F.Q."/>
                <person name="Trippe B.L."/>
                <person name="Wu J."/>
                <person name="Chalfie M."/>
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            <dbReference type="PubMed" id="30291162"/>
            <dbReference type="DOI" id="10.1242/dev.168096"/>
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        <scope>FUNCTION</scope>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="411" mass="46034" checksum="8E93596F5D16CA08" modified="2011-09-21" version="4">MAPESTSSLSDLSGDAEGVWSIDIDQAFQEALAIYPPCGRRKIIISDEGKMYGRNELIARYIKLRCGKTRTRKQVSSHIQVLARKKLRDEQAKKKGDIPSLLQQASPPGGVKSPSAVVFPPVSAAVAAITEISPQSSYSSIVPKVETDQISQQLFKSLPLWSFQQTPGLPIGMDLSQLVFQQSSPDKTVSPVKSEVVEETKPIASSQLTLHSFSAYVKCNKTSLRTELVKIENTLEKDDIDISVFYEKYPKLLRELFEKSEKKDVFFLAKCWANINVSDDVQNCQYAVDSFYSSREKFQLKVSTMACSFGNQAVEKIEQYFPIEFDGSYSFILNNSPMCDYMVKFIAELKKLNVIETMNNVLENFTVLQIVTNSETDELLMVLCFVFEVSQEPEPSCSVYRLIDGGGDSDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="170" xmlns="https://uniprot.org/uniprot">
    <accession>Q19849-6</accession>
    <name>EGL44_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform f of Transcription enhancer factor-like protein egl-44</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Egg-laying defective protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">egl-44</name>
        <name type="ORF">F28B12.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Genes Dev." volume="15" first="789" last="802">
            <title>Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans.</title>
            <authorList>
                <person name="Wu J."/>
                <person name="Duggan A."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="11274062"/>
            <dbReference type="DOI" id="10.1101/gad.857401"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>MUTAGENESIS OF ALA-134 AND ARG-140</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Development" volume="130" first="5217" last="5227">
            <title>Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior.</title>
            <authorList>
                <person name="Yu H."/>
                <person name="Pretot R.F."/>
                <person name="Burglin T.R."/>
                <person name="Sternberg P.W."/>
            </authorList>
            <dbReference type="PubMed" id="12954713"/>
            <dbReference type="DOI" id="10.1242/dev.00678"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ALA-134</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Development" volume="140" first="3838" last="3847">
            <title>Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression.</title>
            <authorList>
                <person name="Feng G."/>
                <person name="Yi P."/>
                <person name="Yang Y."/>
                <person name="Chai Y."/>
                <person name="Tian D."/>
                <person name="Zhu Z."/>
                <person name="Liu J."/>
                <person name="Zhou F."/>
                <person name="Cheng Z."/>
                <person name="Wang X."/>
                <person name="Li W."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="23946438"/>
            <dbReference type="DOI" id="10.1242/dev.098723"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH EGL-46</scope>
        <scope>MUTAGENESIS OF ALA-91; ALA-134; ARG-140 AND ARG-145</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Exp. Cell Res." volume="319" first="931" last="945">
            <title>Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Iwasa H."/>
                <person name="Maimaiti S."/>
                <person name="Kuroyanagi H."/>
                <person name="Kawano S."/>
                <person name="Inami K."/>
                <person name="Timalsina S."/>
                <person name="Ikeda M."/>
                <person name="Nakagawa K."/>
                <person name="Hata Y."/>
            </authorList>
            <dbReference type="PubMed" id="23396260"/>
            <dbReference type="DOI" id="10.1016/j.yexcr.2013.01.020"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH YAP-1</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2017" name="Dev. Biol." volume="432" first="248" last="257">
            <title>Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron.</title>
            <authorList>
                <person name="O'Brien B.M.J."/>
                <person name="Palumbos S.D."/>
                <person name="Novakovic M."/>
                <person name="Shang X."/>
                <person name="Sundararajan L."/>
                <person name="Miller D.M. III"/>
            </authorList>
            <dbReference type="PubMed" id="29031632"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2017.10.009"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2018" name="Development" volume="145" first="0" last="0">
            <title>Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zheng C."/>
                <person name="Jin F.Q."/>
                <person name="Trippe B.L."/>
                <person name="Wu J."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="30291162"/>
            <dbReference type="DOI" id="10.1242/dev.168096"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH EGL-46</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19849-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_041803"/>
        </isoform>
        <isoform>
            <id>Q19849-2</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q19849-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_041804 VSP_041802"/>
        </isoform>
        <isoform>
            <id>Q19849-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_041801"/>
        </isoform>
        <isoform>
            <id>Q19849-1</id>
            <name>b</name>
            <sequence type="described" ref="VSP_041803 VSP_041804"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367307.1">
        <property type="nucleotide sequence ID" value="NM_001381441.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F28B12.2f">
        <property type="protein sequence ID" value="CE44907"/>
        <property type="gene ID" value="WBGene00001208"/>
        <property type="gene designation" value="egl-44"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="435" mass="48357" checksum="E1E62F939460F539" modified="2011-09-21" version="4">MMTLSPPAGDGPGSAGSMAPESTSSLSDLSGDAEGVWSIDIDQAFQEALAIYPPCGRRKIIISDEGKMYGRNELIARYIKLRCGKTRTRKQVSSHIQVLARKKLRDEQAKKKVPFHLNTGDIPSLLQQASPPGGVKSPSAVVFPPVSAAVAAITEISPQSSYSSIVPKVETDQISQQLFKSLPLWSFQQTPGLPIGMDLSQLVFQQSSPDKTVSPVKSEVVEETKPIASSQLTLHSFSAYVKCNKTSLRTELVKIENTLEKDDIDISVFYEKYPKLLRELFEKSEKKDVFFLAKCWANINVSDDVQNCQYAVDSFYSSREKFQLKVSTMACSFGNQAVEKIEQYFPIEFDGSYSFILNNSPMCDYMVKFIAELKKLNVIETMNNVLENFTVLQIVTNSETDELLMVLCFVFEVSQEPEPSCSVYRLIDGGGDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-01-10" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q2V4U0</accession>
    <name>Q2V4U0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">pde-4</name>
        <name evidence="11" type="ORF">CELE_R153.1</name>
        <name evidence="13" type="ORF">R153.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD69646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040798.1">
        <property type="nucleotide sequence ID" value="NM_001047333.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2V4U0"/>
    <dbReference type="SMR" id="Q2V4U0"/>
    <dbReference type="GeneID" id="174235"/>
    <dbReference type="UCSC" id="R153.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020114"/>
    <dbReference type="CTD" id="174235"/>
    <dbReference type="WormBase" id="R153.1g">
        <property type="protein sequence ID" value="CE39396"/>
        <property type="gene ID" value="WBGene00020114"/>
        <property type="gene designation" value="pde-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020114">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2V4U0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106072">
        <property type="term" value="P:negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040013">
        <property type="term" value="P:negative regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000001">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040844">
        <property type="entry name" value="PDE4_UCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18100">
        <property type="entry name" value="PDE4_UCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0114">cAMP</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="327"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="406"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
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        <citation type="journal article" date="1999" name="Science" volume="286" first="1141" last="1146">
            <title>Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins.</title>
            <authorList>
                <person name="Jeon M."/>
                <person name="Gardner H.F."/>
                <person name="Miller E.A."/>
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                <person name="Rougvie A.E."/>
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            <dbReference type="DOI" id="10.1126/science.286.5442.1141"/>
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        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
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            <strain evidence="6">Bristol N2</strain>
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    <reference evidence="5" key="3">
        <citation type="journal article" date="2005" name="Dev. Cell" volume="8" first="287" last="295">
            <title>Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes.</title>
            <authorList>
                <person name="Banerjee D."/>
                <person name="Kwok A."/>
                <person name="Lin S.-Y."/>
                <person name="Slack F.J."/>
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        <citation type="journal article" date="2006" name="Dev. Biol." volume="289" first="30" last="43">
            <title>Novel heterochronic functions of the Caenorhabditis elegans period-related protein LIN-42.</title>
            <authorList>
                <person name="Tennessen J.M."/>
                <person name="Gardner H.F."/>
                <person name="Volk M.L."/>
                <person name="Rougvie A.E."/>
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            <dbReference type="PubMed" id="16300753"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2005.09.044"/>
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        <scope>DEVELOPMENTAL STAGE</scope>
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    <reference key="5">
        <citation type="journal article" date="2010" name="Development" volume="137" first="3501" last="3511">
            <title>The C. elegans developmental timing protein LIN-42 regulates diapause in response to environmental cues.</title>
            <authorList>
                <person name="Tennessen J.M."/>
                <person name="Opperman K.J."/>
                <person name="Rougvie A.E."/>
            </authorList>
            <dbReference type="PubMed" id="20843862"/>
            <dbReference type="DOI" id="10.1242/dev.048850"/>
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        <citation type="journal article" date="2011" name="Curr. Biol." volume="21" first="2033" last="2045">
            <title>LIN-42/PERIOD controls cyclical and developmental progression of C. elegans molts.</title>
            <authorList>
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                <person name="Van Buskirk C."/>
                <person name="Frand A.R."/>
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            <dbReference type="PubMed" id="22137474"/>
            <dbReference type="DOI" id="10.1016/j.cub.2011.10.054"/>
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        <scope>FUNCTION (ISOFORM A)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>ALTERNATIVE SPLICING</scope>
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    <reference key="7">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2014" name="Dev. Biol." volume="390" first="126" last="135">
            <title>The Period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans.</title>
            <authorList>
                <person name="Van Wynsberghe P.M."/>
                <person name="Finnegan E.F."/>
                <person name="Stark T."/>
                <person name="Angelus E.P."/>
                <person name="Homan K.E."/>
                <person name="Yeo G.W."/>
                <person name="Pasquinelli A.E."/>
            </authorList>
            <dbReference type="PubMed" id="24699545"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2014.03.017"/>
        </citation>
        <scope>FUNCTION</scope>
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    <reference key="9">
        <citation type="journal article" date="2014" name="PLoS Genet." volume="10" first="E1004486" last="E1004486">
            <title>LIN-42, the Caenorhabditis elegans PERIOD homolog, negatively regulates microRNA transcription.</title>
            <authorList>
                <person name="Perales R."/>
                <person name="King D.M."/>
                <person name="Aguirre-Chen C."/>
                <person name="Hammell C.M."/>
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            <dbReference type="PubMed" id="25032706"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004486"/>
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        <scope>FUNCTION</scope>
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    <reference key="10">
        <citation type="journal article" date="2014" name="Proc. Natl. Acad. Sci. U.S.A." volume="111" first="15450" last="15455">
            <title>Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression.</title>
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                <person name="Rougvie A.E."/>
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            <dbReference type="DOI" id="10.1073/pnas.1414856111"/>
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            <title>The Doubletime Homolog KIN-20 Mainly Regulates let-7 Independently of Its Effects on the Period Homolog LIN-42 in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Rhodehouse K."/>
                <person name="Cascino K."/>
                <person name="Aseltine L."/>
                <person name="Padula A."/>
                <person name="Weinstein R."/>
                <person name="Spina J.S."/>
                <person name="Olivero C.E."/>
                <person name="Van Wynsberghe P.M."/>
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            <dbReference type="DOI" id="10.1534/g3.118.200392"/>
        </citation>
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        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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        <text evidence="1">Specifically required for maintaining the timing of larval development and molting cycle rhythms.</text>
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        <isoform>
            <id>Q65ZG8-3</id>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <citation type="journal article" date="1999" name="Science" volume="286" first="1141" last="1146">
            <title>Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins.</title>
            <authorList>
                <person name="Jeon M."/>
                <person name="Gardner H.F."/>
                <person name="Miller E.A."/>
                <person name="Deshler J."/>
                <person name="Rougvie A.E."/>
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            <dbReference type="DOI" id="10.1126/science.286.5442.1141"/>
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        <scope>SUBCELLULAR LOCATION</scope>
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    <reference evidence="3" key="3">
        <citation type="journal article" date="2005" name="Dev. Cell" volume="8" first="287" last="295">
            <title>Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes.</title>
            <authorList>
                <person name="Banerjee D."/>
                <person name="Kwok A."/>
                <person name="Lin S.-Y."/>
                <person name="Slack F.J."/>
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        <citation type="journal article" date="2006" name="Dev. Biol." volume="289" first="30" last="43">
            <title>Novel heterochronic functions of the Caenorhabditis elegans period-related protein LIN-42.</title>
            <authorList>
                <person name="Tennessen J.M."/>
                <person name="Gardner H.F."/>
                <person name="Volk M.L."/>
                <person name="Rougvie A.E."/>
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            <dbReference type="DOI" id="10.1016/j.ydbio.2005.09.044"/>
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        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2010" name="Development" volume="137" first="3501" last="3511">
            <title>The C. elegans developmental timing protein LIN-42 regulates diapause in response to environmental cues.</title>
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                <person name="Tennessen J.M."/>
                <person name="Opperman K.J."/>
                <person name="Rougvie A.E."/>
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        <citation type="journal article" date="2011" name="Curr. Biol." volume="21" first="2033" last="2045">
            <title>LIN-42/PERIOD controls cyclical and developmental progression of C. elegans molts.</title>
            <authorList>
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                <person name="Van Buskirk C."/>
                <person name="Frand A.R."/>
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        <scope>FUNCTION (ISOFORM A)</scope>
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    <reference key="7">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
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                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
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            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
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        <scope>FUNCTION</scope>
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    <reference key="8">
        <citation type="journal article" date="2014" name="Dev. Biol." volume="390" first="126" last="135">
            <title>The Period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans.</title>
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                <person name="Van Wynsberghe P.M."/>
                <person name="Finnegan E.F."/>
                <person name="Stark T."/>
                <person name="Angelus E.P."/>
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    <reference key="9">
        <citation type="journal article" date="2014" name="PLoS Genet." volume="10" first="E1004486" last="E1004486">
            <title>LIN-42, the Caenorhabditis elegans PERIOD homolog, negatively regulates microRNA transcription.</title>
            <authorList>
                <person name="Perales R."/>
                <person name="King D.M."/>
                <person name="Aguirre-Chen C."/>
                <person name="Hammell C.M."/>
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            <dbReference type="PubMed" id="25032706"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004486"/>
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        <scope>FUNCTION</scope>
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    <reference key="10">
        <citation type="journal article" date="2014" name="Proc. Natl. Acad. Sci. U.S.A." volume="111" first="15450" last="15455">
            <title>Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression.</title>
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                <person name="Rougvie A.E."/>
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            <dbReference type="DOI" id="10.1073/pnas.1414856111"/>
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        <scope>FUNCTION</scope>
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    <reference key="11">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2617" last="2629">
            <title>The Doubletime Homolog KIN-20 Mainly Regulates let-7 Independently of Its Effects on the Period Homolog LIN-42 in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Rhodehouse K."/>
                <person name="Cascino K."/>
                <person name="Aseltine L."/>
                <person name="Padula A."/>
                <person name="Weinstein R."/>
                <person name="Spina J.S."/>
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    <comment type="miscellaneous">
        <text evidence="2">Produced by alternative splicing.</text>
    </comment>
    <dbReference type="RefSeq" id="NP_001022178.1">
        <property type="nucleotide sequence ID" value="NM_001027007.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F47F6.1c">
        <property type="protein sequence ID" value="CE10706"/>
        <property type="gene ID" value="WBGene00018572"/>
        <property type="gene designation" value="lin-42"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="16300753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="22137474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAF13188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F47F6.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F47F6.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="F47F6.1c"/>
        </source>
    </evidence>
    <sequence length="453" mass="49839" checksum="49A7B5082969CEC6" modified="2004-10-11" version="1">MEPAGHSSATHNIVVPNANPTQPQPLAPAMREEGATLSPPNTWSSSSVEFLDDADDNRLLFTCTFTLPHGTVLSSATYADGFHEQYLTIGDNFLARLEPKGQSFILSAAAASVKQRIFARVTMPDGALRACELLCEFETDRAKITVLALRSAFSLQASHVSSNFHVFTFITKHSSTCALTHIDYASIPYLGLLPTDLIGKSLLAFVYSPDVHVVRQAHIDLHNSRGKIVKSIADLRLVAHNGSILRCQTEWSAYVNPWTRKMELVVARHRICSLPIGDSDVISSPPPGIQSNTLPPVMAKTFEDELRTIMNKVSSAISSVTFLSSGDGASHRLSSSSVLLVLTLHFYLCASLRRDTRLARRIRRRESGQQRHLSEQKVHMLALRSMAPCQEKECKNDALAGGAVSGTTDELIPRRTFLEFAWNGECNFIGGPVLYGSRRDMVQVLQKPTKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6LAA9</accession>
    <name>Q6LAA9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_ZK945.6</name>
        <name evidence="2 4" type="ORF">ZK945.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAE48820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022538.1">
        <property type="nucleotide sequence ID" value="NM_001027367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6LAA9"/>
    <dbReference type="IntAct" id="Q6LAA9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="174574"/>
    <dbReference type="UCSC" id="ZK945.6b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00014168"/>
    <dbReference type="CTD" id="174574"/>
    <dbReference type="WormBase" id="ZK945.6b">
        <property type="protein sequence ID" value="CE35923"/>
        <property type="gene ID" value="WBGene00014168"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087088_0_0_1"/>
    <dbReference type="OrthoDB" id="5799195at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014168">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6LAA9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE48820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZK945.6b"/>
        </source>
    </evidence>
    <sequence length="214" mass="23714" checksum="C959F92FBA2CC5CF" modified="2004-07-05" version="1">MECSQEDVVNDFIALEKIGSEVDINLDGVIKSKECSNTNEADIISNLITAIEESLSCTSVCTAVSLETVAQKLDAYADPSLNTQMSFSTASDLSSMEQDYVKDDPFDLNHQPSPLQVWRDQGKITGFQMMCDDQKVTVVDSLECLAQSEQHLEPVYFDPRVNLAIPCPPDDFEILEDYGSTSNASVNSDDASTAELGPTSEEFEEWVRKIEQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MYP3</accession>
    <name>Q8MYP3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">bed-1</name>
        <name evidence="7" type="ORF">CELE_Y39B6A.12</name>
        <name evidence="9" type="ORF">Y39B6A.12</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAD31811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T45046">
        <property type="entry name" value="T45046"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024227.1">
        <property type="nucleotide sequence ID" value="NM_001029056.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MYP3"/>
    <dbReference type="SMR" id="Q8MYP3"/>
    <dbReference type="DIP" id="DIP-24513N"/>
    <dbReference type="IntAct" id="Q8MYP3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="180257"/>
    <dbReference type="KEGG" id="cel:CELE_Y39B6A.12"/>
    <dbReference type="UCSC" id="Y39B6A.12a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012674"/>
    <dbReference type="CTD" id="180257"/>
    <dbReference type="WormBase" id="Y39B6A.12a">
        <property type="protein sequence ID" value="CE29855"/>
        <property type="gene ID" value="WBGene00012674"/>
        <property type="gene designation" value="bed-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5814137at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012674">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MYP3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD31811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y39B6A.12a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MYP3"/>
        </source>
    </evidence>
    <sequence length="378" mass="41733" checksum="5648394B79B22E22" modified="2002-10-01" version="1">MESTQKDIKLEPDEFNYIIAPGAPESENLAENPENPVDLSEIPLETKPAWFPSSKGRSIVWEHITWVAESQRAACNYCAAEFQVKGGTSALLRHLKTIHPAAINFDPENPPPVARRKRKKMEDYTIVTEDTKSYMDNLLEQFLNVDDSAPRGGLPDHDSPQHMLVVDPQSRADSEIDAVIRNLQQETEQNGLLEPEPDQALKKLLGIDDGRCEEVIAIAAPIQQDEEKQVSSSSGGAQTKKRRADEQKLTENPALNSGKFSLSILSAIRRPPLPSSTATSSSAAAPQIPAMTSSAVASATSAAAAATPMMPAKYNAQAVQILDFEAKVLYNQSLHSTIAREDAMTTYYRMKSRKLELEIKKLERELGEEQDEAQEHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MYP7</accession>
    <name>Q8MYP7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NPH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_R07H5.11</name>
        <name evidence="1 3" type="ORF">R07H5.11</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAD31662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741491.1">
        <property type="nucleotide sequence ID" value="NM_171419.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MYP7"/>
    <dbReference type="GeneID" id="259596"/>
    <dbReference type="UCSC" id="R07H5.11">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011131"/>
    <dbReference type="CTD" id="259596"/>
    <dbReference type="WormBase" id="R07H5.11a">
        <property type="protein sequence ID" value="CE30681"/>
        <property type="gene ID" value="WBGene00011131"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2063594_0_0_1"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011131">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MYP7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD31662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="R07H5.11a"/>
        </source>
    </evidence>
    <sequence length="119" mass="14088" checksum="E512EA0A21C21819" modified="2002-10-01" version="1">MLIHYLQQVELTPVLTNDPFEADHYLAQRVDLSVYEYIRSCMEHSKKVFTDRRMRSESSPTTHLQPHRIMVLSRNRYESIGLRGKFFKNQKKCYSKNCNHKKISEAFLAKSVTNLACQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MYQ0</accession>
    <name>Q8MYQ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hum-2</name>
        <name evidence="3" type="ORF">CELE_F36D4.3</name>
        <name evidence="5" type="ORF">F36D4.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD68603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741590.1">
        <property type="nucleotide sequence ID" value="NM_171505.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MYQ0"/>
    <dbReference type="SMR" id="Q8MYQ0"/>
    <dbReference type="IntAct" id="Q8MYQ0">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="179321"/>
    <dbReference type="UCSC" id="F36D4.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00002036"/>
    <dbReference type="CTD" id="179321"/>
    <dbReference type="WormBase" id="F36D4.3c">
        <property type="protein sequence ID" value="CE30777"/>
        <property type="gene ID" value="WBGene00002036"/>
        <property type="gene designation" value="hum-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002036">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd15470">
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        <property type="entry name" value="Vascular_dev_regulator"/>
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        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
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    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
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        <property type="entry name" value="DIL"/>
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        <property type="entry name" value="DILUTE"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="185"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD68603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F36D4.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MYQ0"/>
        </source>
    </evidence>
    <sequence length="516" mass="58771" checksum="EF8A9139C1D65A14" modified="2002-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q94071-2</accession>
    <name>LIPB_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoform a of Liprin-beta homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>LAR-interacting protein beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hlb-1</name>
        <name evidence="8" type="ORF">T21H8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="15611" last="15620">
            <title>Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.</title>
            <authorList>
                <person name="Serra-Pages C."/>
                <person name="Medley Q.G."/>
                <person name="Tang M."/>
                <person name="Hart A."/>
                <person name="Streuli M."/>
            </authorList>
            <dbReference type="PubMed" id="9624153"/>
            <dbReference type="DOI" id="10.1074/jbc.273.25.15611"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Neurosci. Bull." volume="25" first="75" last="86">
            <title>HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wang D.Y."/>
                <person name="Wang Y."/>
            </authorList>
            <dbReference type="PubMed" id="19290026"/>
            <dbReference type="DOI" id="10.1007/s12264-009-0119-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94071-3</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_060306 VSP_060304"/>
        </isoform>
        <isoform>
            <id>Q94071-7</id>
            <name evidence="6">f</name>
            <sequence type="described" ref="VSP_060300"/>
        </isoform>
        <isoform>
            <id>Q94071-19</id>
            <name evidence="19">s</name>
            <sequence type="described" ref="VSP_060301"/>
        </isoform>
        <isoform>
            <id>Q94071-1</id>
            <name evidence="8">h</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q94071-10</id>
            <name evidence="10">j</name>
            <sequence type="described" ref="VSP_060305"/>
        </isoform>
        <isoform>
            <id>Q94071-11</id>
            <name evidence="11">k</name>
            <sequence type="described" ref="VSP_060310 VSP_060303"/>
        </isoform>
        <isoform>
            <id>Q94071-16</id>
            <name evidence="16">p</name>
            <sequence type="described" ref="VSP_060305 VSP_060307 VSP_060308"/>
        </isoform>
        <isoform>
            <id>Q94071-15</id>
            <name evidence="15">o</name>
            <sequence type="described" ref="VSP_060307 VSP_060308"/>
        </isoform>
        <isoform>
            <id>Q94071-13</id>
            <name evidence="13">m</name>
            <sequence type="described" ref="VSP_060302 VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-6</id>
            <name evidence="5">e</name>
            <sequence type="described" ref="VSP_060310 VSP_060300"/>
        </isoform>
        <isoform>
            <id>Q94071-18</id>
            <name evidence="18">r</name>
            <sequence type="described" ref="VSP_060310 VSP_060301"/>
        </isoform>
        <isoform>
            <id>Q94071-17</id>
            <name evidence="17">q</name>
            <sequence type="described" ref="VSP_060303 VSP_060307 VSP_060308"/>
        </isoform>
        <isoform>
            <id>Q94071-8</id>
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            <id>Q94071-2</id>
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        <isoform>
            <id>Q94071-14</id>
            <name evidence="14">n</name>
            <sequence type="described" ref="VSP_060302"/>
        </isoform>
        <isoform>
            <id>Q94071-4</id>
            <name evidence="3">c</name>
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        </isoform>
        <isoform>
            <id>Q94071-5</id>
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            <sequence type="described" ref="VSP_060306 VSP_060309 VSP_060304"/>
        </isoform>
        <isoform>
            <id>Q94071-12</id>
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        </isoform>
        <isoform>
            <id>Q94071-9</id>
            <name evidence="9">i</name>
            <sequence type="described" ref="VSP_060305 VSP_060310"/>
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    <dbReference type="RefSeq" id="NP_510311.2">
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        <property type="gene ID" value="WBGene00011904"/>
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    <proteinExistence type="evidence at transcript level"/>
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        <source>
            <dbReference type="WormBase" id="T21H8.1a"/>
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    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T21H8.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="T21H8.1i"/>
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    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T21H8.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T21H8.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T21H8.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="T21H8.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="T21H8.1n"/>
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    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="T21H8.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="T21H8.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="T21H8.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="T21H8.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="T21H8.1s"/>
        </source>
    </evidence>
    <sequence length="920" mass="102674" checksum="22A2A59AE94FC19F" modified="2019-09-18" version="5"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q94071-3</accession>
    <name>LIPB_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoform b of Liprin-beta homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>LAR-interacting protein beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hlb-1</name>
        <name evidence="8" type="ORF">T21H8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="15611" last="15620">
            <title>Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.</title>
            <authorList>
                <person name="Serra-Pages C."/>
                <person name="Medley Q.G."/>
                <person name="Tang M."/>
                <person name="Hart A."/>
                <person name="Streuli M."/>
            </authorList>
            <dbReference type="PubMed" id="9624153"/>
            <dbReference type="DOI" id="10.1074/jbc.273.25.15611"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Neurosci. Bull." volume="25" first="75" last="86">
            <title>HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wang D.Y."/>
                <person name="Wang Y."/>
            </authorList>
            <dbReference type="PubMed" id="19290026"/>
            <dbReference type="DOI" id="10.1007/s12264-009-0119-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94071-4</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_060306 VSP_060310 VSP_060309 VSP_060304"/>
        </isoform>
        <isoform>
            <id>Q94071-5</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_060304 VSP_060306 VSP_060309"/>
        </isoform>
        <isoform>
            <id>Q94071-16</id>
            <name evidence="16">p</name>
            <sequence type="described" ref="VSP_060308 VSP_060307 VSP_060305"/>
        </isoform>
        <isoform>
            <id>Q94071-11</id>
            <name evidence="11">k</name>
            <sequence type="described" ref="VSP_060310 VSP_060303"/>
        </isoform>
        <isoform>
            <id>Q94071-14</id>
            <name evidence="14">n</name>
            <sequence type="described" ref="VSP_060302"/>
        </isoform>
        <isoform>
            <id>Q94071-15</id>
            <name evidence="15">o</name>
            <sequence type="described" ref="VSP_060308 VSP_060307"/>
        </isoform>
        <isoform>
            <id>Q94071-9</id>
            <name evidence="9">i</name>
            <sequence type="described" ref="VSP_060310 VSP_060305"/>
        </isoform>
        <isoform>
            <id>Q94071-19</id>
            <name evidence="19">s</name>
            <sequence type="described" ref="VSP_060301"/>
        </isoform>
        <isoform>
            <id>Q94071-17</id>
            <name evidence="17">q</name>
            <sequence type="described" ref="VSP_060303 VSP_060307 VSP_060308"/>
        </isoform>
        <isoform>
            <id>Q94071-6</id>
            <name evidence="5">e</name>
            <sequence type="described" ref="VSP_060310 VSP_060300"/>
        </isoform>
        <isoform>
            <id>Q94071-13</id>
            <name evidence="13">m</name>
            <sequence type="described" ref="VSP_060310 VSP_060302"/>
        </isoform>
        <isoform>
            <id>Q94071-3</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_060304 VSP_060306"/>
        </isoform>
        <isoform>
            <id>Q94071-8</id>
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        </isoform>
        <isoform>
            <id>Q94071-2</id>
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            <sequence type="described" ref="VSP_060304 VSP_060306 VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-10</id>
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            <sequence type="described" ref="VSP_060305"/>
        </isoform>
        <isoform>
            <id>Q94071-12</id>
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            <sequence type="described" ref="VSP_060303"/>
        </isoform>
        <isoform>
            <id>Q94071-18</id>
            <name evidence="18">r</name>
            <sequence type="described" ref="VSP_060310 VSP_060301"/>
        </isoform>
        <isoform>
            <id>Q94071-1</id>
            <name evidence="8">h</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q94071-7</id>
            <name evidence="6">f</name>
            <sequence type="described" ref="VSP_060300"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001123185.1">
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    <dbReference type="WormBase" id="T21H8.1b">
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        <property type="gene ID" value="WBGene00011904"/>
        <property type="gene designation" value="hlb-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
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    <proteinExistence type="evidence at transcript level"/>
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        <source>
            <dbReference type="WormBase" id="T21H8.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T21H8.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T21H8.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T21H8.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T21H8.1g"/>
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    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="T21H8.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="T21H8.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="T21H8.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="T21H8.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="T21H8.1s"/>
        </source>
    </evidence>
    <sequence length="962" mass="107426" checksum="FB9ADF59D26AC969" modified="2019-09-18" version="5"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q94071-4</accession>
    <name>LIPB_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoform c of Liprin-beta homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>LAR-interacting protein beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hlb-1</name>
        <name evidence="8" type="ORF">T21H8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="15611" last="15620">
            <title>Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.</title>
            <authorList>
                <person name="Serra-Pages C."/>
                <person name="Medley Q.G."/>
                <person name="Tang M."/>
                <person name="Hart A."/>
                <person name="Streuli M."/>
            </authorList>
            <dbReference type="PubMed" id="9624153"/>
            <dbReference type="DOI" id="10.1074/jbc.273.25.15611"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Neurosci. Bull." volume="25" first="75" last="86">
            <title>HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wang D.Y."/>
                <person name="Wang Y."/>
            </authorList>
            <dbReference type="PubMed" id="19290026"/>
            <dbReference type="DOI" id="10.1007/s12264-009-0119-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94071-15</id>
            <name evidence="15">o</name>
            <sequence type="described" ref="VSP_060307 VSP_060308"/>
        </isoform>
        <isoform>
            <id>Q94071-3</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_060304 VSP_060306"/>
        </isoform>
        <isoform>
            <id>Q94071-7</id>
            <name evidence="6">f</name>
            <sequence type="described" ref="VSP_060300"/>
        </isoform>
        <isoform>
            <id>Q94071-12</id>
            <name evidence="12">l</name>
            <sequence type="described" ref="VSP_060303"/>
        </isoform>
        <isoform>
            <id>Q94071-18</id>
            <name evidence="18">r</name>
            <sequence type="described" ref="VSP_060310 VSP_060301"/>
        </isoform>
        <isoform>
            <id>Q94071-14</id>
            <name evidence="14">n</name>
            <sequence type="described" ref="VSP_060302"/>
        </isoform>
        <isoform>
            <id>Q94071-19</id>
            <name evidence="19">s</name>
            <sequence type="described" ref="VSP_060301"/>
        </isoform>
        <isoform>
            <id>Q94071-9</id>
            <name evidence="9">i</name>
            <sequence type="described" ref="VSP_060310 VSP_060305"/>
        </isoform>
        <isoform>
            <id>Q94071-10</id>
            <name evidence="10">j</name>
            <sequence type="described" ref="VSP_060305"/>
        </isoform>
        <isoform>
            <id>Q94071-6</id>
            <name evidence="5">e</name>
            <sequence type="described" ref="VSP_060300 VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-2</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_060310 VSP_060304 VSP_060306"/>
        </isoform>
        <isoform>
            <id>Q94071-8</id>
            <name evidence="7">g</name>
            <sequence type="described" ref="VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-4</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_060306 VSP_060309 VSP_060304 VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-5</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_060304 VSP_060306 VSP_060309"/>
        </isoform>
        <isoform>
            <id>Q94071-16</id>
            <name evidence="16">p</name>
            <sequence type="described" ref="VSP_060307 VSP_060305 VSP_060308"/>
        </isoform>
        <isoform>
            <id>Q94071-11</id>
            <name evidence="11">k</name>
            <sequence type="described" ref="VSP_060310 VSP_060303"/>
        </isoform>
        <isoform>
            <id>Q94071-1</id>
            <name evidence="8">h</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q94071-13</id>
            <name evidence="13">m</name>
            <sequence type="described" ref="VSP_060310 VSP_060302"/>
        </isoform>
        <isoform>
            <id>Q94071-17</id>
            <name evidence="17">q</name>
            <sequence type="described" ref="VSP_060308 VSP_060303 VSP_060307"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001309703.1">
        <property type="nucleotide sequence ID" value="NM_001322655.3"/>
    </dbReference>
    <dbReference type="WormBase" id="T21H8.1c">
        <property type="protein sequence ID" value="CE51474"/>
        <property type="gene ID" value="WBGene00011904"/>
        <property type="gene designation" value="hlb-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="T21H8.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T21H8.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T21H8.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T21H8.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T21H8.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T21H8.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T21H8.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T21H8.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T21H8.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T21H8.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T21H8.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T21H8.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="T21H8.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="T21H8.1n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="T21H8.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="T21H8.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="T21H8.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="T21H8.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="T21H8.1s"/>
        </source>
    </evidence>
    <sequence length="873" mass="97011" checksum="31922B4E5A6D4114" modified="2019-09-18" version="5"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q94071-5</accession>
    <name>LIPB_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoform d of Liprin-beta homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>LAR-interacting protein beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hlb-1</name>
        <name evidence="8" type="ORF">T21H8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="15611" last="15620">
            <title>Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.</title>
            <authorList>
                <person name="Serra-Pages C."/>
                <person name="Medley Q.G."/>
                <person name="Tang M."/>
                <person name="Hart A."/>
                <person name="Streuli M."/>
            </authorList>
            <dbReference type="PubMed" id="9624153"/>
            <dbReference type="DOI" id="10.1074/jbc.273.25.15611"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Neurosci. Bull." volume="25" first="75" last="86">
            <title>HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wang D.Y."/>
                <person name="Wang Y."/>
            </authorList>
            <dbReference type="PubMed" id="19290026"/>
            <dbReference type="DOI" id="10.1007/s12264-009-0119-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94071-13</id>
            <name evidence="13">m</name>
            <sequence type="described" ref="VSP_060310 VSP_060302"/>
        </isoform>
        <isoform>
            <id>Q94071-2</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_060304 VSP_060310 VSP_060306"/>
        </isoform>
        <isoform>
            <id>Q94071-17</id>
            <name evidence="17">q</name>
            <sequence type="described" ref="VSP_060303 VSP_060307 VSP_060308"/>
        </isoform>
        <isoform>
            <id>Q94071-19</id>
            <name evidence="19">s</name>
            <sequence type="described" ref="VSP_060301"/>
        </isoform>
        <isoform>
            <id>Q94071-6</id>
            <name evidence="5">e</name>
            <sequence type="described" ref="VSP_060300 VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-5</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_060309 VSP_060306 VSP_060304"/>
        </isoform>
        <isoform>
            <id>Q94071-3</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_060304 VSP_060306"/>
        </isoform>
        <isoform>
            <id>Q94071-12</id>
            <name evidence="12">l</name>
            <sequence type="described" ref="VSP_060303"/>
        </isoform>
        <isoform>
            <id>Q94071-8</id>
            <name evidence="7">g</name>
            <sequence type="described" ref="VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-4</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_060304 VSP_060309 VSP_060306 VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-10</id>
            <name evidence="10">j</name>
            <sequence type="described" ref="VSP_060305"/>
        </isoform>
        <isoform>
            <id>Q94071-14</id>
            <name evidence="14">n</name>
            <sequence type="described" ref="VSP_060302"/>
        </isoform>
        <isoform>
            <id>Q94071-9</id>
            <name evidence="9">i</name>
            <sequence type="described" ref="VSP_060305 VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-7</id>
            <name evidence="6">f</name>
            <sequence type="described" ref="VSP_060300"/>
        </isoform>
        <isoform>
            <id>Q94071-11</id>
            <name evidence="11">k</name>
            <sequence type="described" ref="VSP_060303 VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-16</id>
            <name evidence="16">p</name>
            <sequence type="described" ref="VSP_060307 VSP_060305 VSP_060308"/>
        </isoform>
        <isoform>
            <id>Q94071-15</id>
            <name evidence="15">o</name>
            <sequence type="described" ref="VSP_060308 VSP_060307"/>
        </isoform>
        <isoform>
            <id>Q94071-1</id>
            <name evidence="8">h</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q94071-18</id>
            <name evidence="18">r</name>
            <sequence type="described" ref="VSP_060310 VSP_060301"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001309704.1">
        <property type="nucleotide sequence ID" value="NM_001322656.4"/>
    </dbReference>
    <dbReference type="WormBase" id="T21H8.1d">
        <property type="protein sequence ID" value="CE51489"/>
        <property type="gene ID" value="WBGene00011904"/>
        <property type="gene designation" value="hlb-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="T21H8.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T21H8.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T21H8.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T21H8.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T21H8.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T21H8.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T21H8.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T21H8.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T21H8.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T21H8.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T21H8.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T21H8.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="T21H8.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="T21H8.1n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="T21H8.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="T21H8.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="T21H8.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="T21H8.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="T21H8.1s"/>
        </source>
    </evidence>
    <sequence length="915" mass="101762" checksum="1BFE1CD74ECBB5E8" modified="2019-09-18" version="5"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q94071-6</accession>
    <name>LIPB_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoform e of Liprin-beta homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>LAR-interacting protein beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hlb-1</name>
        <name evidence="8" type="ORF">T21H8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="15611" last="15620">
            <title>Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.</title>
            <authorList>
                <person name="Serra-Pages C."/>
                <person name="Medley Q.G."/>
                <person name="Tang M."/>
                <person name="Hart A."/>
                <person name="Streuli M."/>
            </authorList>
            <dbReference type="PubMed" id="9624153"/>
            <dbReference type="DOI" id="10.1074/jbc.273.25.15611"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Neurosci. Bull." volume="25" first="75" last="86">
            <title>HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wang D.Y."/>
                <person name="Wang Y."/>
            </authorList>
            <dbReference type="PubMed" id="19290026"/>
            <dbReference type="DOI" id="10.1007/s12264-009-0119-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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        <event type="alternative splicing"/>
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            <id>Q94071-11</id>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
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        </source>
    </evidence>
    <sequence length="641" mass="71764" checksum="7404BC1E56EB36FF" modified="2019-09-18" version="5"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditina</taxon>
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    <reference key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="15611" last="15620">
            <title>Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.</title>
            <authorList>
                <person name="Serra-Pages C."/>
                <person name="Medley Q.G."/>
                <person name="Tang M."/>
                <person name="Hart A."/>
                <person name="Streuli M."/>
            </authorList>
            <dbReference type="PubMed" id="9624153"/>
            <dbReference type="DOI" id="10.1074/jbc.273.25.15611"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Neurosci. Bull." volume="25" first="75" last="86">
            <title>HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wang D.Y."/>
                <person name="Wang Y."/>
            </authorList>
            <dbReference type="PubMed" id="19290026"/>
            <dbReference type="DOI" id="10.1007/s12264-009-0119-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94071-12</id>
            <name evidence="12">l</name>
            <sequence type="described" ref="VSP_060303"/>
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            <name evidence="16">p</name>
            <sequence type="described" ref="VSP_060307 VSP_060308 VSP_060305"/>
        </isoform>
        <isoform>
            <id>Q94071-10</id>
            <name evidence="10">j</name>
            <sequence type="described" ref="VSP_060305"/>
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        <isoform>
            <id>Q94071-8</id>
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            <sequence type="described" ref="VSP_060310"/>
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            <id>Q94071-7</id>
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        </isoform>
        <isoform>
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</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
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    <reference key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="15611" last="15620">
            <title>Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.</title>
            <authorList>
                <person name="Serra-Pages C."/>
                <person name="Medley Q.G."/>
                <person name="Tang M."/>
                <person name="Hart A."/>
                <person name="Streuli M."/>
            </authorList>
            <dbReference type="PubMed" id="9624153"/>
            <dbReference type="DOI" id="10.1074/jbc.273.25.15611"/>
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        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Neurosci. Bull." volume="25" first="75" last="86">
            <title>HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wang D.Y."/>
                <person name="Wang Y."/>
            </authorList>
            <dbReference type="PubMed" id="19290026"/>
            <dbReference type="DOI" id="10.1007/s12264-009-0119-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94071-11</id>
            <name evidence="11">k</name>
            <sequence type="described" ref="VSP_060303 VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-9</id>
            <name evidence="9">i</name>
            <sequence type="described" ref="VSP_060310 VSP_060305"/>
        </isoform>
        <isoform>
            <id>Q94071-1</id>
            <name evidence="8">h</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q94071-4</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_060304 VSP_060310 VSP_060309 VSP_060306"/>
        </isoform>
        <isoform>
            <id>Q94071-14</id>
            <name evidence="14">n</name>
            <sequence type="described" ref="VSP_060302"/>
        </isoform>
        <isoform>
            <id>Q94071-7</id>
            <name evidence="6">f</name>
            <sequence type="described" ref="VSP_060300"/>
        </isoform>
        <isoform>
            <id>Q94071-2</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_060304 VSP_060306 VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-16</id>
            <name evidence="16">p</name>
            <sequence type="described" ref="VSP_060305 VSP_060308 VSP_060307"/>
        </isoform>
        <isoform>
            <id>Q94071-3</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_060306 VSP_060304"/>
        </isoform>
        <isoform>
            <id>Q94071-6</id>
            <name evidence="5">e</name>
            <sequence type="described" ref="VSP_060310 VSP_060300"/>
        </isoform>
        <isoform>
            <id>Q94071-8</id>
            <name evidence="7">g</name>
            <sequence type="described" ref="VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-5</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_060304 VSP_060309 VSP_060306"/>
        </isoform>
        <isoform>
            <id>Q94071-10</id>
            <name evidence="10">j</name>
            <sequence type="described" ref="VSP_060305"/>
        </isoform>
        <isoform>
            <id>Q94071-13</id>
            <name evidence="13">m</name>
            <sequence type="described" ref="VSP_060302 VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-18</id>
            <name evidence="18">r</name>
            <sequence type="described" ref="VSP_060310 VSP_060301"/>
        </isoform>
        <isoform>
            <id>Q94071-15</id>
            <name evidence="15">o</name>
            <sequence type="described" ref="VSP_060308 VSP_060307"/>
        </isoform>
        <isoform>
            <id>Q94071-19</id>
            <name evidence="19">s</name>
            <sequence type="described" ref="VSP_060301"/>
        </isoform>
        <isoform>
            <id>Q94071-17</id>
            <name evidence="17">q</name>
            <sequence type="described" ref="VSP_060303 VSP_060307 VSP_060308"/>
        </isoform>
        <isoform>
            <id>Q94071-12</id>
            <name evidence="12">l</name>
            <sequence type="described" ref="VSP_060303"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001309707.1">
        <property type="nucleotide sequence ID" value="NM_001322647.4"/>
    </dbReference>
    <dbReference type="WormBase" id="T21H8.1g">
        <property type="protein sequence ID" value="CE51523"/>
        <property type="gene ID" value="WBGene00011904"/>
        <property type="gene designation" value="hlb-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="T21H8.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T21H8.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T21H8.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T21H8.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T21H8.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T21H8.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T21H8.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T21H8.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T21H8.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T21H8.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T21H8.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T21H8.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="T21H8.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="T21H8.1n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="T21H8.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="T21H8.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="T21H8.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="T21H8.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="T21H8.1s"/>
        </source>
    </evidence>
    <sequence length="962" mass="107960" checksum="14409849FDC1AB96" modified="2019-09-18" version="5"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q94071-9</accession>
    <name>LIPB_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoform i of Liprin-beta homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>LAR-interacting protein beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hlb-1</name>
        <name evidence="8" type="ORF">T21H8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="15611" last="15620">
            <title>Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.</title>
            <authorList>
                <person name="Serra-Pages C."/>
                <person name="Medley Q.G."/>
                <person name="Tang M."/>
                <person name="Hart A."/>
                <person name="Streuli M."/>
            </authorList>
            <dbReference type="PubMed" id="9624153"/>
            <dbReference type="DOI" id="10.1074/jbc.273.25.15611"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Neurosci. Bull." volume="25" first="75" last="86">
            <title>HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wang D.Y."/>
                <person name="Wang Y."/>
            </authorList>
            <dbReference type="PubMed" id="19290026"/>
            <dbReference type="DOI" id="10.1007/s12264-009-0119-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94071-19</id>
            <name evidence="19">s</name>
            <sequence type="described" ref="VSP_060301"/>
        </isoform>
        <isoform>
            <id>Q94071-6</id>
            <name evidence="5">e</name>
            <sequence type="described" ref="VSP_060310 VSP_060300"/>
        </isoform>
        <isoform>
            <id>Q94071-16</id>
            <name evidence="16">p</name>
            <sequence type="described" ref="VSP_060305 VSP_060307 VSP_060308"/>
        </isoform>
        <isoform>
            <id>Q94071-11</id>
            <name evidence="11">k</name>
            <sequence type="described" ref="VSP_060310 VSP_060303"/>
        </isoform>
        <isoform>
            <id>Q94071-13</id>
            <name evidence="13">m</name>
            <sequence type="described" ref="VSP_060310 VSP_060302"/>
        </isoform>
        <isoform>
            <id>Q94071-14</id>
            <name evidence="14">n</name>
            <sequence type="described" ref="VSP_060302"/>
        </isoform>
        <isoform>
            <id>Q94071-15</id>
            <name evidence="15">o</name>
            <sequence type="described" ref="VSP_060308 VSP_060307"/>
        </isoform>
        <isoform>
            <id>Q94071-2</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_060304 VSP_060310 VSP_060306"/>
        </isoform>
        <isoform>
            <id>Q94071-3</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_060304 VSP_060306"/>
        </isoform>
        <isoform>
            <id>Q94071-17</id>
            <name evidence="17">q</name>
            <sequence type="described" ref="VSP_060307 VSP_060303 VSP_060308"/>
        </isoform>
        <isoform>
            <id>Q94071-12</id>
            <name evidence="12">l</name>
            <sequence type="described" ref="VSP_060303"/>
        </isoform>
        <isoform>
            <id>Q94071-4</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_060306 VSP_060309 VSP_060304 VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-8</id>
            <name evidence="7">g</name>
            <sequence type="described" ref="VSP_060310"/>
        </isoform>
        <isoform>
            <id>Q94071-7</id>
            <name evidence="6">f</name>
            <sequence type="described" ref="VSP_060300"/>
        </isoform>
        <isoform>
            <id>Q94071-5</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_060306 VSP_060304 VSP_060309"/>
        </isoform>
        <isoform>
            <id>Q94071-10</id>
            <name evidence="10">j</name>
            <sequence type="described" ref="VSP_060305"/>
        </isoform>
        <isoform>
            <id>Q94071-1</id>
            <name evidence="8">h</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q94071-9</id>
            <name evidence="9">i</name>
            <sequence type="described" ref="VSP_060310 VSP_060305"/>
        </isoform>
        <isoform>
            <id>Q94071-18</id>
            <name evidence="18">r</name>
            <sequence type="described" ref="VSP_060301 VSP_060310"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001309709.1">
        <property type="nucleotide sequence ID" value="NM_001322649.4"/>
    </dbReference>
    <dbReference type="WormBase" id="T21H8.1i">
        <property type="protein sequence ID" value="CE51461"/>
        <property type="gene ID" value="WBGene00011904"/>
        <property type="gene designation" value="hlb-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="T21H8.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T21H8.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T21H8.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T21H8.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T21H8.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T21H8.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T21H8.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T21H8.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T21H8.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T21H8.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T21H8.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T21H8.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="T21H8.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="T21H8.1n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="T21H8.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="T21H8.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="T21H8.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="T21H8.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="T21H8.1s"/>
        </source>
    </evidence>
    <sequence length="936" mass="104979" checksum="173943B62953E9C5" modified="2019-09-18" version="5"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N4M7</accession>
    <name>Q9N4M7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">spp-7</name>
        <name evidence="6" type="ORF">CELE_ZK616.9</name>
        <name evidence="8" type="ORF">ZK616.9</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD71115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_500808.1">
        <property type="nucleotide sequence ID" value="NM_068407.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N4M7"/>
    <dbReference type="SMR" id="Q9N4M7"/>
    <dbReference type="PaxDb" id="6239-ZK616.9"/>
    <dbReference type="GeneID" id="177326"/>
    <dbReference type="UCSC" id="ZK616.9">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004992"/>
    <dbReference type="CTD" id="177326"/>
    <dbReference type="WormBase" id="ZK616.9a">
        <property type="protein sequence ID" value="CE26344"/>
        <property type="gene ID" value="WBGene00004992"/>
        <property type="gene designation" value="spp-7"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R1EC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5803636at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004992">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N4M7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF91">
        <property type="entry name" value="SAPOSIN B-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331582" evidence="4">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="5">
        <location>
            <begin position="242"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD71115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="ZK616.9a"/>
        </source>
    </evidence>
    <sequence length="318" mass="36192" checksum="B0DA0A2B0BB0EA92" modified="2000-10-01" version="1">MRINLFFVFAVLGQQFQVTFTYFWNEEPVVRERASPSPNGNTPSNLGCFMCTQLLSVTKHRVGLSENQLRNQLYEKCRVLPSVFKEQCFAFVETSLPEIYYSINYDISSKDVCVRMNFCDERNPFAIGGPLPSIEATTLYPEEEAEEIELPTTTTRRRTTTTTTTTTPPPTTTTTVRTTTALTRPNPSIEQVRREEHNDRIGHKNVLEIIIPPPLRSKYMSRNTIVESSREKVPEKEEIDEKRLTCAFCERMLENAKNYAVTSKTDITSFANTACASLAKGTTSDQCYQMADKKIAELAKFVDQQVVDALWCAELNRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEU2</accession>
    <name>U4PEU2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C32B5.7</name>
        <name evidence="2" type="ORF">CELE_C32B5.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293575.1">
        <property type="nucleotide sequence ID" value="NM_001306646.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEU2"/>
    <dbReference type="SMR" id="U4PEU2"/>
    <dbReference type="GeneID" id="183111"/>
    <dbReference type="AGR" id="WB:WBGene00016300"/>
    <dbReference type="CTD" id="183111"/>
    <dbReference type="WormBase" id="C32B5.7c">
        <property type="protein sequence ID" value="CE49010"/>
        <property type="gene ID" value="WBGene00016300"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2707031_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016300">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEU2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C32B5.7c"/>
        </source>
    </evidence>
    <sequence length="73" mass="8163" checksum="CA6E4C283499C4F7" modified="2013-12-11" version="1">MSDESLALVFIDERGPGLFTMNTPPSFFNYKSGIYNPTEEECKSTNEKRALTIVGYGNDKGQNYWIVKGSFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEU7</accession>
    <name>U4PEU7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear hormone receptor E75</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">nhr-41</name>
        <name evidence="14" type="ORF">CELE_Y104H12A.1</name>
        <name evidence="16" type="ORF">Y104H12A.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294481.1">
        <property type="nucleotide sequence ID" value="NM_001307552.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEU7"/>
    <dbReference type="SMR" id="U4PEU7"/>
    <dbReference type="GeneID" id="190865"/>
    <dbReference type="AGR" id="WB:WBGene00022423"/>
    <dbReference type="CTD" id="190865"/>
    <dbReference type="WormBase" id="Y104H12A.1c">
        <property type="protein sequence ID" value="CE48869"/>
        <property type="gene ID" value="WBGene00022423"/>
        <property type="gene designation" value="nhr-41"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007368_16_2_1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022423">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEU7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000059">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000015">
        <property type="entry name" value="Nuclear receptor subfamily 2, group C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="221"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDH93263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="Y104H12A.1c"/>
        </source>
    </evidence>
    <sequence length="513" mass="57255" checksum="C9B7C39AAD7DDD8B" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEV1</accession>
    <name>U4PEV1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C09E9.1</name>
        <name evidence="1" type="ORF">CELE_C09E9.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368278.1">
        <property type="nucleotide sequence ID" value="NM_001380040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEV1"/>
    <dbReference type="PeptideAtlas" id="U4PEV1"/>
    <dbReference type="GeneID" id="182452"/>
    <dbReference type="AGR" id="WB:WBGene00007476"/>
    <dbReference type="CTD" id="182452"/>
    <dbReference type="WormBase" id="C09E9.1c">
        <property type="protein sequence ID" value="CE48972"/>
        <property type="gene ID" value="WBGene00007476"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2028822_0_0_1"/>
    <dbReference type="OrthoDB" id="9025707at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007476">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEV1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029393">
        <property type="entry name" value="FUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15453">
        <property type="entry name" value="TUMOR SUPPRESSOR CANDIDATE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15453:SF8">
        <property type="entry name" value="TUMOR SUPPRESSOR CANDIDATE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15000">
        <property type="entry name" value="TUSC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="C09E9.1c"/>
        </source>
    </evidence>
    <sequence length="46" mass="5545" checksum="DB4F9850FA30B7C9" modified="2013-12-11" version="1">MSDGEKRRLCRLMKNLRPKGKERYAIPRLKHDIPVVIWEVQQPQET</sequence>
</entry>
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    <accession>U4PEV8</accession>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
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            <end position="376"/>
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            <end position="550"/>
        </location>
    </feature>
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            <begin position="617"/>
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            <begin position="8"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CDH93273.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="F53H1.1c"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="U4PEV8"/>
        </source>
    </evidence>
    <sequence length="833" mass="94689" checksum="45CA9E4E1CB64283" modified="2013-12-11" version="1"> </sequence>
</entry>
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            <strain evidence="6 7">Bristol N2</strain>
        </source>
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        <subcellularLocation>
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        <property type="gene designation" value="osta-3"/>
    </dbReference>
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        <property type="component" value="Chromosome II"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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            <end position="29"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="212"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH93278.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="W01D2.5b"/>
        </source>
    </evidence>
    <sequence length="246" mass="27926" checksum="29189EC29A9D765F" modified="2013-12-11" version="1">MCVPRTAVILTCIGVLYYLMCLFVIVSLARHLFGGRESFSTCLQYDDRPIDFRSPPFCCIIPKLPTARSTEKNIRRLEWCVLQAPIVRSIIIFLDVVAVAEMREDATPYIRYSDMASLCSLLLAIFGVHTLARVTSNKLSAYCFMSMFRLVDISLLFFSAQQPMIFQNVLLRFNLISCGPLLNAQENAYFVCNFIITCEMLLLSVLATWLLAPRHNAMFDAYRPSMALSETTASLNETEQSMILDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF68</accession>
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        <submittedName>
            <fullName evidence="2">TPR_REGION domain-containing protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">CELE_Y76B12C.6</name>
        <name evidence="2 4" type="ORF">Y76B12C.6</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001307654.1"/>
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    <dbReference type="KEGG" id="cel:CELE_Y76B12C.6"/>
    <dbReference type="AGR" id="WB:WBGene00022300"/>
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        <property type="protein sequence ID" value="CE49124"/>
        <property type="gene ID" value="WBGene00022300"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_475091_0_0_1"/>
    <dbReference type="OrthoDB" id="5793189at2759"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022300">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF68">
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y76B12C.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PF68"/>
        </source>
    </evidence>
    <sequence length="551" mass="61639" checksum="6A1429FCDE3F6547" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF73</accession>
    <name>U4PF73_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kazal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ost-1</name>
        <name evidence="10" type="ORF">C44B12.2</name>
        <name evidence="8" type="ORF">CELE_C44B12.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368314.1">
        <property type="nucleotide sequence ID" value="NM_001380031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PF73"/>
    <dbReference type="SMR" id="U4PF73"/>
    <dbReference type="PeptideAtlas" id="U4PF73"/>
    <dbReference type="GeneID" id="176931"/>
    <dbReference type="AGR" id="WB:WBGene00003893"/>
    <dbReference type="CTD" id="176931"/>
    <dbReference type="WormBase" id="C44B12.2b">
        <property type="protein sequence ID" value="CE48586"/>
        <property type="gene ID" value="WBGene00003893"/>
        <property type="gene designation" value="ost-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047416_1_0_1"/>
    <dbReference type="OrthoDB" id="9972865at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003893">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF73">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16231">
        <property type="entry name" value="EFh_SPARC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000234">
        <property type="entry name" value="Protein BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001999">
        <property type="entry name" value="Osteonectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00613">
        <property type="entry name" value="OSTEONECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDH93391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="C44B12.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="U4PF73"/>
        </source>
    </evidence>
    <sequence length="177" mass="20765" checksum="6D62DC0C2BA31801" modified="2013-12-11" version="1">MDKVCANNNQTFTSLCDLYRERCLCKRKSKECSKAFNAKVHLEYLGECKKLDECTEEHMAQFPERMADWLFQVMKELKKRRELHKLEWEELLSEAENDDEKKHVYPVIWKFCELDTKPHDKSVSHHELIPITAPVIPMESCIKPFLEGCDANNDGNISIKEWGKCLGLKEGEIQERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF78</accession>
    <name>U4PF78_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_Y67D8A.2</name>
        <name evidence="5 7" type="ORF">Y67D8A.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PF78"/>
    <dbReference type="SMR" id="U4PF78"/>
    <dbReference type="AGR" id="WB:WBGene00022059"/>
    <dbReference type="WormBase" id="Y67D8A.2d">
        <property type="protein sequence ID" value="CE48776"/>
        <property type="gene ID" value="WBGene00022059"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004177_0_1_1"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022059">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF78">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="4">
        <location>
            <begin position="321"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y67D8A.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="U4PF78"/>
        </source>
    </evidence>
    <sequence length="597" mass="67452" checksum="5E5C0EA648542427" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF86</accession>
    <name>U4PF86_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_Y67D8A.2</name>
        <name evidence="6 8" type="ORF">Y67D8A.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PF86"/>
    <dbReference type="SMR" id="U4PF86"/>
    <dbReference type="PeptideAtlas" id="U4PF86"/>
    <dbReference type="AGR" id="WB:WBGene00022059"/>
    <dbReference type="WormBase" id="Y67D8A.2i">
        <property type="protein sequence ID" value="CE48692"/>
        <property type="gene ID" value="WBGene00022059"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457285_0_0_1"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022059">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF86">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004653335" description="Phosphorylase b kinase regulatory subunit" evidence="4">
        <location>
            <begin position="21"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="5">
        <location>
            <begin position="222"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH93401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y67D8A.2i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="U4PF86"/>
        </source>
    </evidence>
    <sequence length="505" mass="57031" checksum="8FABCA37BA2DB99A" modified="2013-12-11" version="1">MERPRLLAFAIWILWSRTHPDLLVHNFTLRERLEKVYRRACQLRLWWLVRYCAGRLHKAMNSLAPAITNMLVRGKQITLGVRNRPGAREEIIVRPIAPSDLNRLLFECCPADEPQAAVFHQELIIACSDLMSHNPQVFEGVLTIRLSWLSDAISMLLNYVRITGALKFSGVSTGTPPTPGTTGIPTELDFIRKLIRTKYRREKVIEEFKKSCIYDLSPTVVKDVVTALMTRTNWHLLSSLQTRRLNGALNRMPVNFYDRVWTILERSTHGIIIADQFLPQQPTLSDMTRFELTFSYKIEAMLSRISHPEYRQLLVELLSIIATILERNPEIAFTHSRIDCDSLIKKGFALFAAEEGIKDLNDLTPFYQLEGQALSTSTATFLTKAVVEFILAGRHFSQVINIFGEGTPEEKTLPSQHHRGKMPKIAYTGRASSEKKKRHVGGSSSSSQHHHHHQQQQTPLLRLATPLTPEPSSGTVTPRAITPSPLSSSLNTSGGGGQDESCRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>W6RTH3</accession>
    <name>W6RTH3_CAEEL</name>
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        <submittedName>
            <fullName evidence="9">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">sax-7</name>
        <name evidence="11" type="ORF">C18F3.2</name>
        <name evidence="9" type="ORF">CELE_C18F3.2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294162.1">
        <property type="nucleotide sequence ID" value="NM_001307233.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RTH3"/>
    <dbReference type="GeneID" id="177602"/>
    <dbReference type="AGR" id="WB:WBGene00004732"/>
    <dbReference type="CTD" id="177602"/>
    <dbReference type="WormBase" id="C18F3.2f">
        <property type="protein sequence ID" value="CE49486"/>
        <property type="gene ID" value="WBGene00004732"/>
        <property type="gene designation" value="sax-7"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004732">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RTH3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026966">
        <property type="entry name" value="Neurofascin/L1/NrCAM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13882">
        <property type="entry name" value="Bravo_FIGEY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880733" evidence="7">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM63517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C18F3.2f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="W6RTH3"/>
        </source>
    </evidence>
    <sequence length="249" mass="27523" checksum="486F15B87FA8C120" modified="2014-04-16" version="1">MFHIISFLLFTHLRFLASAPNSVDPGVPSLVENAIGDKYFNVSFRPAKYDDESRAPVGNTYEVQYKPQDADEWETVKPADDGLTVHVDGLSPGTKYDVRVAALQVDPEGGETTKTLSGISKITTTGTSSRERNVYLLILLLLILLLLLIICCICCVVCRQRGQNYPVSQREREQGREPILGKPDYKTDDDEKRSLTGSKAESETDSMAQYGDTDPGVFTEDGSFIGQYVPQKSLMPAERPEKGSTSTFV</sequence>
</entry>
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    <accession>G5EDE2-2</accession>
    <name>CBXH2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Chromobox protein homolog hpl-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HP1-like heterochromatin protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 6" type="primary">hpl-2</name>
        <name evidence="4" type="synonym">K01G5.2a</name>
        <name evidence="6" type="ORF">K01G5.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="1999-01" db="EMBL/GenBank/DDBJ databases">
            <title>A novel chromo-domain protein in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Bahrami M."/>
                <person name="Schulze E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2002" name="EMBO Rep." volume="3" first="235" last="241">
            <title>A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development.</title>
            <authorList>
                <person name="Couteau F."/>
                <person name="Guerry F."/>
                <person name="Muller F."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="11850401"/>
            <dbReference type="DOI" id="10.1093/embo-reports/kvf051"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2006" name="Dev. Biol." volume="297" first="308" last="322">
            <title>The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development.</title>
            <authorList>
                <person name="Coustham V."/>
                <person name="Bedet C."/>
                <person name="Monier K."/>
                <person name="Schott S."/>
                <person name="Karali M."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="16890929"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2006.04.474"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT(ISOFORM A)</scope>
        <scope>INTERACTION WITH LIN-13</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2006" name="Dev. Biol." volume="298" first="176" last="187">
            <title>Unique and redundant functions of C. elegans HP1 proteins in post-embryonic development.</title>
            <authorList>
                <person name="Schott S."/>
                <person name="Coustham V."/>
                <person name="Simonet T."/>
                <person name="Bedet C."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="16905130"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2006.06.039"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2007" name="Dev. Biol." volume="312" first="367" last="383">
            <title>Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development.</title>
            <authorList>
                <person name="Simonet T."/>
                <person name="Dulermo R."/>
                <person name="Schott S."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="17967446"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.09.035"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="7">
        <citation type="journal article" date="2009" name="Genetics" volume="181" first="797" last="801">
            <title>HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells.</title>
            <authorList>
                <person name="Schott S."/>
                <person name="Ramos F."/>
                <person name="Coustham V."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="19064713"/>
            <dbReference type="DOI" id="10.1534/genetics.108.089276"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="8">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R123.1" last="R123.18">
            <title>Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism.</title>
            <authorList>
                <person name="Meister P."/>
                <person name="Schott S."/>
                <person name="Bedet C."/>
                <person name="Xiao Y."/>
                <person name="Rohner S."/>
                <person name="Bodennec S."/>
                <person name="Hudry B."/>
                <person name="Molin L."/>
                <person name="Solari F."/>
                <person name="Gasser S.M."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="22185090"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-12-r123"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="9">
        <citation type="journal article" date="2012" name="Mol. Cell. Biol." volume="32" first="251" last="265">
            <title>Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.</title>
            <authorList>
                <person name="Studencka M."/>
                <person name="Konzer A."/>
                <person name="Moneron G."/>
                <person name="Wenzel D."/>
                <person name="Opitz L."/>
                <person name="Salinas-Riester G."/>
                <person name="Bedet C."/>
                <person name="Krueger M."/>
                <person name="Hell S.W."/>
                <person name="Wisniewski J.R."/>
                <person name="Schmidt H."/>
                <person name="Palladino F."/>
                <person name="Schulze E."/>
                <person name="Jedrusik-Bode M."/>
            </authorList>
            <dbReference type="PubMed" id="22083954"/>
            <dbReference type="DOI" id="10.1128/mcb.05229-11"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HIS-24 AND HPL-1</scope>
    </reference>
    <reference evidence="2" key="10">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="e1002940" last="e1002940">
            <title>Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.</title>
            <authorList>
                <person name="Studencka M."/>
                <person name="Wesolowski R."/>
                <person name="Opitz L."/>
                <person name="Salinas-Riester G."/>
                <person name="Wisniewski J.R."/>
                <person name="Jedrusik-Bode M."/>
            </authorList>
            <dbReference type="PubMed" id="23028351"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002940"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HISTONE H3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="11">
        <citation type="journal article" date="2014" name="Proc. Natl. Acad. Sci. U.S.A." volume="111" first="5956" last="5961">
            <title>The Caenorhabditis elegans HP1 family protein HPL-2 maintains ER homeostasis through the UPR and hormesis.</title>
            <authorList>
                <person name="Kozlowski L."/>
                <person name="Garvis S."/>
                <person name="Bedet C."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="24715729"/>
            <dbReference type="DOI" id="10.1073/pnas.1321698111"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="12">
        <citation type="journal article" date="2015" name="Genome Res." volume="25" first="76" last="88">
            <title>Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2.</title>
            <authorList>
                <person name="Garrigues J.M."/>
                <person name="Sidoli S."/>
                <person name="Garcia B.A."/>
                <person name="Strome S."/>
            </authorList>
            <dbReference type="PubMed" id="25467431"/>
            <dbReference type="DOI" id="10.1101/gr.180489.114"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="2" key="13">
        <citation type="journal article" date="2015" name="Nucleic Acids Res." volume="43" first="9694" last="9710">
            <title>H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Vandamme J."/>
                <person name="Sidoli S."/>
                <person name="Mariani L."/>
                <person name="Friis C."/>
                <person name="Christensen J."/>
                <person name="Helin K."/>
                <person name="Jensen O.N."/>
                <person name="Salcini A.E."/>
            </authorList>
            <dbReference type="PubMed" id="26476455"/>
            <dbReference type="DOI" id="10.1093/nar/gkv1063"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HISTONE H3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="14">
        <citation type="journal article" date="2018" name="Mol. Cell. Biol." volume="38" first="0" last="0">
            <title>The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2.</title>
            <authorList>
                <person name="Saldi T.K."/>
                <person name="Gonzales P."/>
                <person name="Garrido-Lecca A."/>
                <person name="Dostal V."/>
                <person name="Roberts C.M."/>
                <person name="Petrucelli L."/>
                <person name="Link C.D."/>
            </authorList>
            <dbReference type="PubMed" id="29760282"/>
            <dbReference type="DOI" id="10.1128/mcb.00668-17"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH TDP-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EDE2-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_061516"/>
        </isoform>
        <isoform>
            <id>G5EDE2-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EDE2-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_061517"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022653.1">
        <property type="nucleotide sequence ID" value="NM_001027482.4"/>
    </dbReference>
    <dbReference type="WormBase" id="K01G5.2b">
        <property type="protein sequence ID" value="CE25037"/>
        <property type="gene ID" value="WBGene00001996"/>
        <property type="gene designation" value="hpl-2"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="11850401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAD21196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAD21197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="K01G5.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K01G5.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="K01G5.2c"/>
        </source>
    </evidence>
    <sequence length="301" mass="34660" checksum="CE305D1775E240A2" modified="2011-12-14" version="1">MSSKSTKRAKIEDPKDNVFMVEKVLDKRTGKAGRDEFLIQWQGFPESDSSWEPRENLQCVEMLDEFEREFSKREKPIRKRHSQKPEPSEDQADPEEDKDEKKETNQNDKFSLEGKQLKCIVGLTKGPGELHFLCKFSDDTARLLPAKEVNSRYRPFVDAYGEFLKKKMERRHKRISEGKKKRSIEEDDADDEWPEMPPGHRILTTEEHELQRRKESKISQDVEMTEAQTAADMLNDMHMAANGDLLSSFPQDFLEDSGDGEVHEAAILSVFDDNSNSPPPCPIVVDTVPDDDDSLLFPRNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-05-25" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>G5EDE2-3</accession>
    <name>CBXH2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform c of Chromobox protein homolog hpl-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HP1-like heterochromatin protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 6" type="primary">hpl-2</name>
        <name evidence="4" type="synonym">K01G5.2a</name>
        <name evidence="6" type="ORF">K01G5.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="1999-01" db="EMBL/GenBank/DDBJ databases">
            <title>A novel chromo-domain protein in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Bahrami M."/>
                <person name="Schulze E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2002" name="EMBO Rep." volume="3" first="235" last="241">
            <title>A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development.</title>
            <authorList>
                <person name="Couteau F."/>
                <person name="Guerry F."/>
                <person name="Muller F."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="11850401"/>
            <dbReference type="DOI" id="10.1093/embo-reports/kvf051"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2006" name="Dev. Biol." volume="297" first="308" last="322">
            <title>The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development.</title>
            <authorList>
                <person name="Coustham V."/>
                <person name="Bedet C."/>
                <person name="Monier K."/>
                <person name="Schott S."/>
                <person name="Karali M."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="16890929"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2006.04.474"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT(ISOFORM A)</scope>
        <scope>INTERACTION WITH LIN-13</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2006" name="Dev. Biol." volume="298" first="176" last="187">
            <title>Unique and redundant functions of C. elegans HP1 proteins in post-embryonic development.</title>
            <authorList>
                <person name="Schott S."/>
                <person name="Coustham V."/>
                <person name="Simonet T."/>
                <person name="Bedet C."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="16905130"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2006.06.039"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2007" name="Dev. Biol." volume="312" first="367" last="383">
            <title>Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development.</title>
            <authorList>
                <person name="Simonet T."/>
                <person name="Dulermo R."/>
                <person name="Schott S."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="17967446"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.09.035"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="7">
        <citation type="journal article" date="2009" name="Genetics" volume="181" first="797" last="801">
            <title>HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells.</title>
            <authorList>
                <person name="Schott S."/>
                <person name="Ramos F."/>
                <person name="Coustham V."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="19064713"/>
            <dbReference type="DOI" id="10.1534/genetics.108.089276"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="8">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R123.1" last="R123.18">
            <title>Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism.</title>
            <authorList>
                <person name="Meister P."/>
                <person name="Schott S."/>
                <person name="Bedet C."/>
                <person name="Xiao Y."/>
                <person name="Rohner S."/>
                <person name="Bodennec S."/>
                <person name="Hudry B."/>
                <person name="Molin L."/>
                <person name="Solari F."/>
                <person name="Gasser S.M."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="22185090"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-12-r123"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="9">
        <citation type="journal article" date="2012" name="Mol. Cell. Biol." volume="32" first="251" last="265">
            <title>Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.</title>
            <authorList>
                <person name="Studencka M."/>
                <person name="Konzer A."/>
                <person name="Moneron G."/>
                <person name="Wenzel D."/>
                <person name="Opitz L."/>
                <person name="Salinas-Riester G."/>
                <person name="Bedet C."/>
                <person name="Krueger M."/>
                <person name="Hell S.W."/>
                <person name="Wisniewski J.R."/>
                <person name="Schmidt H."/>
                <person name="Palladino F."/>
                <person name="Schulze E."/>
                <person name="Jedrusik-Bode M."/>
            </authorList>
            <dbReference type="PubMed" id="22083954"/>
            <dbReference type="DOI" id="10.1128/mcb.05229-11"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HIS-24 AND HPL-1</scope>
    </reference>
    <reference evidence="2" key="10">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="e1002940" last="e1002940">
            <title>Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.</title>
            <authorList>
                <person name="Studencka M."/>
                <person name="Wesolowski R."/>
                <person name="Opitz L."/>
                <person name="Salinas-Riester G."/>
                <person name="Wisniewski J.R."/>
                <person name="Jedrusik-Bode M."/>
            </authorList>
            <dbReference type="PubMed" id="23028351"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002940"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HISTONE H3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="11">
        <citation type="journal article" date="2014" name="Proc. Natl. Acad. Sci. U.S.A." volume="111" first="5956" last="5961">
            <title>The Caenorhabditis elegans HP1 family protein HPL-2 maintains ER homeostasis through the UPR and hormesis.</title>
            <authorList>
                <person name="Kozlowski L."/>
                <person name="Garvis S."/>
                <person name="Bedet C."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="24715729"/>
            <dbReference type="DOI" id="10.1073/pnas.1321698111"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="12">
        <citation type="journal article" date="2015" name="Genome Res." volume="25" first="76" last="88">
            <title>Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2.</title>
            <authorList>
                <person name="Garrigues J.M."/>
                <person name="Sidoli S."/>
                <person name="Garcia B.A."/>
                <person name="Strome S."/>
            </authorList>
            <dbReference type="PubMed" id="25467431"/>
            <dbReference type="DOI" id="10.1101/gr.180489.114"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="2" key="13">
        <citation type="journal article" date="2015" name="Nucleic Acids Res." volume="43" first="9694" last="9710">
            <title>H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Vandamme J."/>
                <person name="Sidoli S."/>
                <person name="Mariani L."/>
                <person name="Friis C."/>
                <person name="Christensen J."/>
                <person name="Helin K."/>
                <person name="Jensen O.N."/>
                <person name="Salcini A.E."/>
            </authorList>
            <dbReference type="PubMed" id="26476455"/>
            <dbReference type="DOI" id="10.1093/nar/gkv1063"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HISTONE H3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="14">
        <citation type="journal article" date="2018" name="Mol. Cell. Biol." volume="38" first="0" last="0">
            <title>The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2.</title>
            <authorList>
                <person name="Saldi T.K."/>
                <person name="Gonzales P."/>
                <person name="Garrido-Lecca A."/>
                <person name="Dostal V."/>
                <person name="Roberts C.M."/>
                <person name="Petrucelli L."/>
                <person name="Link C.D."/>
            </authorList>
            <dbReference type="PubMed" id="29760282"/>
            <dbReference type="DOI" id="10.1128/mcb.00668-17"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH TDP-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EDE2-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EDE2-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_061516"/>
        </isoform>
        <isoform>
            <id>G5EDE2-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_061517"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022654.1">
        <property type="nucleotide sequence ID" value="NM_001027483.3"/>
    </dbReference>
    <dbReference type="WormBase" id="K01G5.2c">
        <property type="protein sequence ID" value="CE25038"/>
        <property type="gene ID" value="WBGene00001996"/>
        <property type="gene designation" value="hpl-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="11850401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAD21196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAD21197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="K01G5.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K01G5.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="K01G5.2c"/>
        </source>
    </evidence>
    <sequence length="303" mass="34935" checksum="84BFAB82427CADC7" modified="2011-12-14" version="1">MSSKSTKRAKIEDPKDNVFMVEKVLDKRTGKAGRDEFLIQWQGFPESDSSWEPRENLQCVEMLDEFEREFSKREKPIRKRHSQKPEPSEDQADPEEDKDEKKETNQNDKFSLEGKQLKCIVGLTKGPGELHFLCKFSDDTARLLPAKEVNSRYRPFVDAYGEFLKKKMERRHKRISEGKKKRSIEEDDADDEWPEMPPGHRILTTEEHELQRRKESKISQDVEMTEAFQQTAADMLNDMHMAANGDLLSSFPQDFLEDSGDGEVHEAAILSVFDDNSNSPPPCPIVVDTVPDDDDSLLFPRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZL4</accession>
    <name>H2KZL4_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">DM13 domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">CELE_W01C8.5</name>
        <name evidence="3 5" type="ORF">W01C8.5</name>
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    <organism evidence="3 4">
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD68671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123187.1">
        <property type="nucleotide sequence ID" value="NM_001129715.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZL4"/>
    <dbReference type="PeptideAtlas" id="H2KZL4"/>
    <dbReference type="GeneID" id="180836"/>
    <dbReference type="KEGG" id="cel:CELE_W01C8.5"/>
    <dbReference type="AGR" id="WB:WBGene00020921"/>
    <dbReference type="CTD" id="180836"/>
    <dbReference type="WormBase" id="W01C8.5b">
        <property type="protein sequence ID" value="CE41163"/>
        <property type="gene ID" value="WBGene00020921"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_861176_0_0_1"/>
    <dbReference type="OrthoDB" id="2448405at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020921">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZL4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF5">
        <property type="entry name" value="THROMBOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM13" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD68671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W01C8.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZL4"/>
        </source>
    </evidence>
    <sequence length="323" mass="36548" checksum="8CA1C208730E65DD" modified="2012-03-21" version="1">MIIPFGRYKLRIRDAILGNYCTLFFLAIAISEISENYRGGKDIILELPENYDIFHIDWISVYCYKYRVNFGSVLVPTDDTLVNLPPYVPSIKKNTDGKPMARGVLKGSAERTNFTFQLGDVEHIKNLNGNLRSPKYVWHVNSVMSPDLYLMRNVTYNFNVEGGREKMIPELYNPLYIGDDENGGFSELSQNEAERVTIHSPGLIESNTGPLCIWMHNKDKAANEPDTYLECDGWPEDVHSFAFTPNETTPSVLYYNSGNNFNMGGRIFIVDELPENIADSAEVPYSREKWHTLALSRQRADKVNGGKATLAAVFLIIVTIILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZL8</accession>
    <name>H2KZL8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">5'-nucleotidase</fullName>
            <ecNumber evidence="3 9">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_F25B5.3</name>
        <name evidence="10 12" type="ORF">F25B5.3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3 9"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD68777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741161.1">
        <property type="nucleotide sequence ID" value="NM_171141.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZL8"/>
    <dbReference type="SMR" id="H2KZL8"/>
    <dbReference type="PeptideAtlas" id="H2KZL8"/>
    <dbReference type="GeneID" id="175843"/>
    <dbReference type="AGR" id="WB:WBGene00017775"/>
    <dbReference type="CTD" id="175843"/>
    <dbReference type="WormBase" id="F25B5.3d">
        <property type="protein sequence ID" value="CE30663"/>
        <property type="gene ID" value="WBGene00017775"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017775">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZL8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07504">
        <property type="entry name" value="HAD_5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.340:FF:000001">
        <property type="entry name" value="Cytosolic 5-nucleotidase 3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000300">
        <property type="entry name" value="Putative cytosolic 5'-nucleotidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.340">
        <property type="entry name" value="Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01544">
        <property type="entry name" value="HAD-SF-IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045:SF0">
        <property type="entry name" value="7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01128">
        <property type="entry name" value="C1.4:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD68777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F25B5.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZL8"/>
        </source>
    </evidence>
    <sequence length="352" mass="39218" checksum="E117F7C28CE0268E" modified="2012-03-21" version="1">MNSANSSETLTDTPLSATLDQSQFSMFKAAEIVNAAAACAEAECIEQLKKTDVVPLLMNYLLGEEQILVADPTAVAAKLRKMVVGGAGKTVVISDFDYTLSRFANEQGERLSTTHGVFDDNVMRLKPELGQKFVDLKNKYYPIEFSPNLTMEEKIPHMEKWWGTSHSLIVNEKFSKNTIEDFVRQSRIVFKDGAEDFIEALDAHNIPLVIFSAGIGNIIEYFLQQKLGAIPRNTHFISNMILFDEDDNACAFSEPLIHTFCKNSSVIQKETSFFHDIAGRVNVILLGDSMGDIHMDVGVERDGPTLKVGYYNGSLDDTAALQHYEEVYDIVLIHDPTLNVAQKIVDIINSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZL9</accession>
    <name>H2KZL9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4139 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_ZK1055.6</name>
        <name evidence="4 6" type="ORF">ZK1055.6</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD68849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZL9"/>
    <dbReference type="SMR" id="H2KZL9"/>
    <dbReference type="PeptideAtlas" id="H2KZL9"/>
    <dbReference type="AGR" id="WB:WBGene00022847"/>
    <dbReference type="WormBase" id="ZK1055.6a">
        <property type="protein sequence ID" value="CE18475"/>
        <property type="gene ID" value="WBGene00022847"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068793at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022847">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZL9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02231">
        <property type="entry name" value="mucoidy inhibitor MuiA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF3">
        <property type="entry name" value="PROTEIN F37C4.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="3">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="2">
        <location>
            <begin position="182"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD68849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="ZK1055.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZL9"/>
        </source>
    </evidence>
    <sequence length="531" mass="59433" checksum="542AB7A8E40C2870" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZM3</accession>
    <name>H2KZM3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUppressor of activated let-60 Ras</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">sur-7</name>
        <name evidence="2" type="ORF">CELE_F01G12.2</name>
        <name evidence="4" type="ORF">F01G12.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD68904.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379862.1">
        <property type="nucleotide sequence ID" value="NM_001392907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZM3"/>
    <dbReference type="PeptideAtlas" id="H2KZM3"/>
    <dbReference type="GeneID" id="181707"/>
    <dbReference type="KEGG" id="cel:CELE_F01G12.2"/>
    <dbReference type="AGR" id="WB:WBGene00006353"/>
    <dbReference type="CTD" id="181707"/>
    <dbReference type="WormBase" id="F01G12.2a">
        <property type="protein sequence ID" value="CE47462"/>
        <property type="gene ID" value="WBGene00006353"/>
        <property type="gene designation" value="sur-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1205713_0_0_1"/>
    <dbReference type="OrthoDB" id="5873812at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006353">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZM3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071294">
        <property type="term" value="P:cellular response to zinc ion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD68904.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F01G12.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZM3"/>
        </source>
    </evidence>
    <sequence length="230" mass="26087" checksum="6F9C27BA8E6553BB" modified="2012-05-16" version="2">MKCTTRFILRYTNHTLYLSTADLVIKAIFSVIYNALSIHFVPNFIALVAPPVLTILIFFYNVNELDYFFGWLNHHLEPVTSILLTIVCISIAIYSLIRKKQFLLAEGPREFKIDDISSSVKAKNSRLEKVDHVHASCEWPQGFTVSLKAYIKVEKTNKDWVAQAASDFYELKALLHHEIKAQGAKEVVVEPVFVDQTELTTDFMDPICISRSCHNEDVGCCTIPKSTGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZN0</accession>
    <name>H2KZN0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">hrpf-1</name>
        <name evidence="6" type="ORF">CELE_W02D3.11</name>
        <name evidence="8" type="ORF">W02D3.11</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD68996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359979.1">
        <property type="nucleotide sequence ID" value="NM_001372997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZN0"/>
    <dbReference type="SMR" id="H2KZN0"/>
    <dbReference type="IntAct" id="H2KZN0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="H2KZN0"/>
    <dbReference type="GeneID" id="172395"/>
    <dbReference type="KEGG" id="cel:CELE_W02D3.11"/>
    <dbReference type="AGR" id="WB:WBGene00020936"/>
    <dbReference type="CTD" id="172395"/>
    <dbReference type="WormBase" id="W02D3.11b">
        <property type="protein sequence ID" value="CE31078"/>
        <property type="gene ID" value="WBGene00020936"/>
        <property type="gene designation" value="hrpf-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_765554_0_0_1"/>
    <dbReference type="OrthoDB" id="431068at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020936">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZN0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="123"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD68996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="W02D3.11b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZN0"/>
        </source>
    </evidence>
    <sequence length="362" mass="40981" checksum="E5626F413DC85EBF" modified="2012-03-21" version="1">MSTAYEVQCRGLPWEATEQELRDFFGNNGIESLEIPRRNGRTSGDAKVVFTNEEDYNNALKKDREHLGSRYIEVFPAGGAPTRRGDRGERGDRGDRDHYRSRGAPPRDRYSDRGGPRSSGPDSIVRLRGLPFSVTSRDISDFLAPLPIVRDGILLPDQQRARPGGEAYVCFETMESVQIAKQRHMKNIGHRYIEVFEATHRDLSRFAEENDLRVPRFGPPPFASAPQTAPRGAYDPYSQPTDPYRNATDYRRAAEPEDPYARSRAPSVQDYGVRASYDPYTQPAAPVSSYPSQQQPSAGYYDNYAPKTAYESYGRERGPDPRDVRDPRDSRMPDPRDSRALSDPYAAESSWRSYAPIRIRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZN3</accession>
    <name>H2KZN3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">kin-9</name>
        <name evidence="8" type="ORF">CELE_F08F1.1</name>
        <name evidence="10" type="ORF">F08F1.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69024.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359980.1">
        <property type="nucleotide sequence ID" value="NM_001373394.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZN3"/>
    <dbReference type="SMR" id="H2KZN3"/>
    <dbReference type="GeneID" id="181098"/>
    <dbReference type="AGR" id="WB:WBGene00002195"/>
    <dbReference type="CTD" id="181098"/>
    <dbReference type="WormBase" id="F08F1.1a">
        <property type="protein sequence ID" value="CE53133"/>
        <property type="gene ID" value="WBGene00002195"/>
        <property type="gene designation" value="kin-9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035850_0_0_1"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002195">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZN3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000575">
        <property type="entry name" value="Protein KINase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="106"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD69024.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F08F1.1a"/>
        </source>
    </evidence>
    <sequence length="418" mass="47859" checksum="3B0FB3B2E5AF36E9" modified="2019-07-31" version="2">MPEENEPWWRPTTPLYYDPYYGGDKHSSEGGVNAVALGLGIGIPLGIIAFGLALFIFFWCRKRRRQNKNQFPLPFPKKVNDYETQLDSPAYSIHDPWLLDRNNLEINYSKKLGSGAFCNVFKGKINGEAPVSQIHPGQRTQLLRDCPVAVKMLPSFADDAARSDFMQEINFMKSLAYHPHLVSMLGFVADRKSPYLLVEFCEHGDLLHMIRNRRQEIINGPTENPDGLKIKDLLMFSWQISNGLEYLNNIGCIHRDIAARNVLVDSANTCKIGDFGLCRLTDSLLYTARGGRLPLKWMAPESLATYEYSYKSDVWSYGVLLWELFSLGEVPYGEVQTTELLQTHRSGKRLLKPEWCPEEIYDVMRLCWQELPDDRPAFQQTCAVLAQMLENATENYGYLIPKHFNNQTRDPSEQCDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZN4</accession>
    <name>H2KZN4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">kin-9</name>
        <name evidence="9" type="ORF">CELE_F08F1.1</name>
        <name evidence="11" type="ORF">F08F1.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69025.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359981.1">
        <property type="nucleotide sequence ID" value="NM_001373393.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZN4"/>
    <dbReference type="SMR" id="H2KZN4"/>
    <dbReference type="STRING" id="6239.F08F1.1b.1"/>
    <dbReference type="PaxDb" id="6239-F08F1.1b"/>
    <dbReference type="GeneID" id="181098"/>
    <dbReference type="AGR" id="WB:WBGene00002195"/>
    <dbReference type="CTD" id="181098"/>
    <dbReference type="WormBase" id="F08F1.1b">
        <property type="protein sequence ID" value="CE53425"/>
        <property type="gene ID" value="WBGene00002195"/>
        <property type="gene designation" value="kin-9"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="PhylomeDB" id="H2KZN4"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002195">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZN4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000575">
        <property type="entry name" value="Protein KINase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020918744" evidence="7">
        <location>
            <begin position="21"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="243"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD69025.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F08F1.1b"/>
        </source>
    </evidence>
    <sequence length="555" mass="63014" checksum="B3799BACC2B1351B" modified="2019-07-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZP1</accession>
    <name>H2KZP1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">kap-1</name>
        <name evidence="1" type="ORF">CELE_F08F8.3</name>
        <name evidence="3" type="ORF">F08F8.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD69059.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367739.1">
        <property type="nucleotide sequence ID" value="NM_001379791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZP1"/>
    <dbReference type="EMDB" id="EMD-64192"/>
    <dbReference type="SMR" id="H2KZP1"/>
    <dbReference type="STRING" id="6239.F08F8.3a.1"/>
    <dbReference type="PaxDb" id="6239-F08F8.3a"/>
    <dbReference type="GeneID" id="176041"/>
    <dbReference type="AGR" id="WB:WBGene00002182"/>
    <dbReference type="CTD" id="176041"/>
    <dbReference type="WormBase" id="F08F8.3a">
        <property type="protein sequence ID" value="CE54188"/>
        <property type="gene ID" value="WBGene00002182"/>
        <property type="gene designation" value="kap-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009879_1_0_1"/>
    <dbReference type="OrthoDB" id="10265679at2759"/>
    <dbReference type="PhylomeDB" id="H2KZP1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002182">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZP1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030993">
        <property type="term" value="C:axonemal heterotrimeric kinesin-II complex"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902856">
        <property type="term" value="P:negative regulation of non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902857">
        <property type="term" value="P:positive regulation of non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001602">
        <property type="entry name" value="Kinesin associated protein kap-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008658">
        <property type="entry name" value="KAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605:SF2">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05804">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01297">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD69059.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F08F8.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZP1"/>
        </source>
    </evidence>
    <sequence length="710" mass="80119" checksum="77599D104E599F8D" modified="2020-06-17" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZP2</accession>
    <name>H2KZP2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F08F8.9</name>
        <name evidence="2 4" type="ORF">F08F8.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD69067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_498623.1">
        <property type="nucleotide sequence ID" value="NM_066222.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZP2"/>
    <dbReference type="SMR" id="H2KZP2"/>
    <dbReference type="PeptideAtlas" id="H2KZP2"/>
    <dbReference type="GeneID" id="176045"/>
    <dbReference type="AGR" id="WB:WBGene00017274"/>
    <dbReference type="CTD" id="176045"/>
    <dbReference type="WormBase" id="F08F8.9b">
        <property type="protein sequence ID" value="CE27937"/>
        <property type="gene ID" value="WBGene00017274"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10686785at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017274">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZP2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
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</entry>
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            <begin position="362"/>
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            <begin position="47"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene designation" value="hgap-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009983at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008430">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2Q8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="D2085.5h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2Q8"/>
        </source>
    </evidence>
    <sequence length="1139" mass="124965" checksum="8840DD6C1DCBAE52" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2R0</accession>
    <name>H9G2R0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F08B12.4</name>
        <name evidence="2 4" type="ORF">F08B12.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCG28116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2R0"/>
    <dbReference type="SMR" id="H9G2R0"/>
    <dbReference type="PeptideAtlas" id="H9G2R0"/>
    <dbReference type="AGR" id="WB:WBGene00008572"/>
    <dbReference type="WormBase" id="F08B12.4g">
        <property type="protein sequence ID" value="CE47172"/>
        <property type="gene ID" value="WBGene00008572"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160206_0_0_1"/>
    <dbReference type="OrthoDB" id="5852690at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008572">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2R0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F08B12.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2R0"/>
        </source>
    </evidence>
    <sequence length="82" mass="8506" checksum="4C2E15ED8C0494EF" modified="2012-05-16" version="1">MPVEQDGLTGGRGVPHPNSAAGQALSGGMTGGSAVPHPNSAAGQELTNKNLEEKSVLEGGTQVKPWLKNQPDLANIREQNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2R1</accession>
    <name>H9G2R1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F08B12.4</name>
        <name evidence="2 4" type="ORF">F08B12.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCG28117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257152.1">
        <property type="nucleotide sequence ID" value="NM_001270223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2R1"/>
    <dbReference type="SMR" id="H9G2R1"/>
    <dbReference type="PeptideAtlas" id="H9G2R1"/>
    <dbReference type="GeneID" id="181333"/>
    <dbReference type="AGR" id="WB:WBGene00008572"/>
    <dbReference type="CTD" id="181333"/>
    <dbReference type="WormBase" id="F08B12.4h">
        <property type="protein sequence ID" value="CE47445"/>
        <property type="gene ID" value="WBGene00008572"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160206_1_0_1"/>
    <dbReference type="OrthoDB" id="5852690at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008572">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2R1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F08B12.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2R1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6657" checksum="D8C75A403B769E41" modified="2012-05-16" version="1">MPVEQDGLTGGRGVPHPNSAAGQELTNKNLEEKSVLEGGTQVKPWLKNQPDLANIREQNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2R2</accession>
    <name>H9G2R2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F08B12.4</name>
        <name evidence="3 5" type="ORF">F08B12.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCG28118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2R2"/>
    <dbReference type="SMR" id="H9G2R2"/>
    <dbReference type="PeptideAtlas" id="H9G2R2"/>
    <dbReference type="AGR" id="WB:WBGene00008572"/>
    <dbReference type="WormBase" id="F08B12.4e">
        <property type="protein sequence ID" value="CE47379"/>
        <property type="gene ID" value="WBGene00008572"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852690at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008572">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2R2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003619608" evidence="2">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F08B12.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2R2"/>
        </source>
    </evidence>
    <sequence length="98" mass="10176" checksum="1A38471BE51AEB2A" modified="2012-05-16" version="1">MNSFVILAIVLAIVNAMPVEQDGLTGGRGVPHPNSAAGQALSGGMTGGSAVPHPNSAAGQELTNKNLEEKSVLEGGTQVKPWLKNQPDLANIREQNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2R3</accession>
    <name>H9G2R3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">slo-2</name>
        <name evidence="14" type="ORF">CELE_F08B12.3</name>
        <name evidence="16" type="ORF">F08B12.3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCG28119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257145.1">
        <property type="nucleotide sequence ID" value="NM_001270216.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2R3"/>
    <dbReference type="SMR" id="H9G2R3"/>
    <dbReference type="GeneID" id="181332"/>
    <dbReference type="AGR" id="WB:WBGene00004831"/>
    <dbReference type="CTD" id="181332"/>
    <dbReference type="WormBase" id="F08B12.3f">
        <property type="protein sequence ID" value="CE47297"/>
        <property type="gene ID" value="WBGene00004831"/>
        <property type="gene designation" value="slo-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257992at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004831">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2R3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000034">
        <property type="entry name" value="Potassium channel subfamily T member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000188">
        <property type="entry name" value="SLOwpoke potassium channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000532">
        <property type="entry name" value="SLOwpoke potassium channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="13">
        <location>
            <begin position="337"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCG28119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="F08B12.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2R3"/>
        </source>
    </evidence>
    <sequence length="1125" mass="129249" checksum="E0C5F740D70265A1" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2R5</accession>
    <name>H9G2R5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F08B12.4</name>
        <name evidence="2 4" type="ORF">F08B12.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCG28121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257156.1">
        <property type="nucleotide sequence ID" value="NM_001270227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2R5"/>
    <dbReference type="PeptideAtlas" id="H9G2R5"/>
    <dbReference type="GeneID" id="181333"/>
    <dbReference type="AGR" id="WB:WBGene00008572"/>
    <dbReference type="CTD" id="181333"/>
    <dbReference type="WormBase" id="F08B12.4c">
        <property type="protein sequence ID" value="CE47129"/>
        <property type="gene ID" value="WBGene00008572"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160206_0_0_1"/>
    <dbReference type="OrthoDB" id="5852690at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008572">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2R5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F08B12.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2R5"/>
        </source>
    </evidence>
    <sequence length="54" mass="5863" checksum="FEF257E17E592A17" modified="2012-05-16" version="1">MTGGSAVPHPNSAAGQELTNKNLEEKSVLEGGTQVKPWLKNQPDLANIREQNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2S4</accession>
    <name>H9G2S4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srm-3</name>
        <name evidence="2" type="ORF">CELE_F58G6.2</name>
        <name evidence="4" type="ORF">F58G6.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255412.1">
        <property type="nucleotide sequence ID" value="NM_001268483.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2S4"/>
    <dbReference type="SMR" id="H9G2S4"/>
    <dbReference type="GeneID" id="186545"/>
    <dbReference type="KEGG" id="cel:CELE_F58G6.2"/>
    <dbReference type="AGR" id="WB:WBGene00010273"/>
    <dbReference type="CTD" id="186545"/>
    <dbReference type="WormBase" id="F58G6.2b">
        <property type="protein sequence ID" value="CE47457"/>
        <property type="gene ID" value="WBGene00010273"/>
        <property type="gene designation" value="srm-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1236019_0_0_1"/>
    <dbReference type="OrthoDB" id="5792363at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010273">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2S4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47758:SF2">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47758">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F58G6.2b"/>
        </source>
    </evidence>
    <sequence length="216" mass="24591" checksum="329E999630ACCD2A" modified="2012-05-16" version="1">MRSLSSKKEANKAISTMPIAVVISSLILIFFGYVPPFYEIHISSLVLEKIAEQGDTAFLIVTVRLTIEDTNTFQLLSQICTLFILIVMFISIIIVILCYTFIQKQMKTRFSASSITKKSQEQLNMTLLLQFILPFVTIHVPFYIIVILPFFRIAGRVLSDHLLLLFCWCPAINPILVILMIKNVQDQLIPKKFSKTSTMSKLSQAQSKSIRVINLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2S5</accession>
    <name>H9G2S5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor elt-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">elt-1</name>
        <name evidence="2" type="ORF">CELE_W09C2.1</name>
        <name evidence="4" type="ORF">W09C2.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255404.1">
        <property type="nucleotide sequence ID" value="NM_001268475.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2S5"/>
    <dbReference type="GeneID" id="177794"/>
    <dbReference type="AGR" id="WB:WBGene00001249"/>
    <dbReference type="CTD" id="177794"/>
    <dbReference type="WormBase" id="W09C2.1e">
        <property type="protein sequence ID" value="CE47448"/>
        <property type="gene ID" value="WBGene00001249"/>
        <property type="gene designation" value="elt-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_662645_0_0_1"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001249">
        <property type="expression patterns" value="Expressed in embryo and 24 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2S5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009957">
        <property type="term" value="P:epidermal cell fate specification"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="W09C2.1e"/>
        </source>
    </evidence>
    <sequence length="106" mass="11738" checksum="DC3A676EBE2CC555" modified="2012-05-16" version="1">MKKDGIQTRNRKLSAKGSRRMKKENGGTPTSMGMPTTSSSISSGIELDQSGVWGMKNTQPMLMTPTAYAFPASNFYFNSIEDQLEYKTCPPMMVDFGGQMKNLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2S6</accession>
    <name>H9G2S6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GATA-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">elt-1</name>
        <name evidence="12" type="ORF">CELE_W09C2.1</name>
        <name evidence="14" type="ORF">W09C2.1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368126.1">
        <property type="nucleotide sequence ID" value="NM_001380414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2S6"/>
    <dbReference type="SMR" id="H9G2S6"/>
    <dbReference type="GeneID" id="177794"/>
    <dbReference type="AGR" id="WB:WBGene00001249"/>
    <dbReference type="CTD" id="177794"/>
    <dbReference type="WormBase" id="W09C2.1c">
        <property type="protein sequence ID" value="CE47204"/>
        <property type="gene ID" value="WBGene00001249"/>
        <property type="gene designation" value="elt-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001249">
        <property type="expression patterns" value="Expressed in embryo and 24 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2S6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009957">
        <property type="term" value="P:epidermal cell fate specification"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000054">
        <property type="entry name" value="Transcription factor elt-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF328">
        <property type="entry name" value="TRANSCRIPTION FACTOR ELT-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="282"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="337"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCG28207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="W09C2.1c"/>
        </source>
    </evidence>
    <sequence length="487" mass="52979" checksum="9F9917BEC8A728EE" modified="2012-05-16" version="1">MHYRDANYSISRNKVNLHHEEFMLDGVVGGEDHDMQNTNEVRAELDSLLRLDPDTNSIIDALHISQPIEENMDYEGKPVEFTLGTSSGGASLAPTSSTTAASIAPFSYNTSATNYYNTTPSSYPMFLNYQYAGGTTVTTDMDAFSGMDMSMNNGVFGTQNNPSYFYPTTQLNTYGYDTLAAATTASGITVNNNQLNVNIVQGNGTIVPQPITQNIISTVSNVQSSVPINNSQPLTPTGLAGCSTSSGSSSASSSSANSTSTPKNTISKANRSSGGANNSQFSTEDRECVNCGVHNTPLWRRDGSGNYLCNACGLYFKMNHHARPLVKPKKRQQNAQKRTGIECVNCRTNTTTLWRRNGEGHPVCNACGLYFKLHKVERPITMKKDGIQTRNRKLSAKGSRRMKKENGGTPTSMGMPTTSSSISSGIELDQSGVWGMKNTQPMLMTPTAYAFPASNFYFNSIEDQLEYKTCPPMMVDFGGQMKNLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2S7</accession>
    <name>H9G2S7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GATA-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">elt-1</name>
        <name evidence="12" type="ORF">CELE_W09C2.1</name>
        <name evidence="14" type="ORF">W09C2.1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255402.1">
        <property type="nucleotide sequence ID" value="NM_001268473.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2S7"/>
    <dbReference type="SMR" id="H9G2S7"/>
    <dbReference type="GeneID" id="177794"/>
    <dbReference type="AGR" id="WB:WBGene00001249"/>
    <dbReference type="CTD" id="177794"/>
    <dbReference type="WormBase" id="W09C2.1d">
        <property type="protein sequence ID" value="CE47360"/>
        <property type="gene ID" value="WBGene00001249"/>
        <property type="gene designation" value="elt-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001249">
        <property type="expression patterns" value="Expressed in embryo and 24 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2S7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009957">
        <property type="term" value="P:epidermal cell fate specification"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000054">
        <property type="entry name" value="Transcription factor elt-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF328">
        <property type="entry name" value="TRANSCRIPTION FACTOR ELT-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="283"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="337"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCG28208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="W09C2.1d"/>
        </source>
    </evidence>
    <sequence length="487" mass="52979" checksum="F68A96E78495BA93" modified="2012-05-16" version="1">MHYRDANYSISRNKVNLHHEEFMLDGVVGGEDHDMQNTNEVRAELDSLLRLDPDTNSIIDALHISQPIEQENMDYEGKPVEFTLGTSSGGASLAPTSSTTAASIAPFSYNTSATNYYNTTPSSYPMFLNYQYAGGTTVTTDMDAFSGMDMSMNNGVFGTQNNPSYFYPTTQLNTYGYDTLAAATTASGITVNNNQLNVNIVQGNGTIVPQPITQNIISTVSNVQSSVPINNSQPLTPTGLAGCSTSSGSSSASSSSANSTSTPKNTISKANRSSGGANNSQFSTEDRECVNCGVHNTPLWRRDGSGNYLCNACGLYFKMNHHARPLVKPKKRQNAQKRTGIECVNCRTNTTTLWRRNGEGHPVCNACGLYFKLHKVERPITMKKDGIQTRNRKLSAKGSRRMKKENGGTPTSMGMPTTSSSISSGIELDQSGVWGMKNTQPMLMTPTAYAFPASNFYFNSIEDQLEYKTCPPMMVDFGGQMKNLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2S9</accession>
    <name>H9G2S9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable insulin-like peptide beta-type 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ins-7</name>
        <name evidence="7" type="ORF">CELE_ZK1251.2</name>
        <name evidence="9" type="ORF">ZK1251.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255417.1">
        <property type="nucleotide sequence ID" value="NM_001268488.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2S9"/>
    <dbReference type="SMR" id="H9G2S9"/>
    <dbReference type="PeptideAtlas" id="H9G2S9"/>
    <dbReference type="GeneID" id="191688"/>
    <dbReference type="AGR" id="WB:WBGene00002090"/>
    <dbReference type="CTD" id="191688"/>
    <dbReference type="WormBase" id="ZK1251.2b">
        <property type="protein sequence ID" value="CE47202"/>
        <property type="gene ID" value="WBGene00002090"/>
        <property type="gene designation" value="ins-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154797_0_0_1"/>
    <dbReference type="PhylomeDB" id="H9G2S9"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002090">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2S9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.100.10:FF:000006">
        <property type="entry name" value="Probable insulin-like peptide beta-type 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052335">
        <property type="entry name" value="Insulin-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003235">
        <property type="entry name" value="Nem_insulin-like_b-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33893:SF5">
        <property type="entry name" value="INSULIN RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33893">
        <property type="entry name" value="INSULIN RELATED-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03488">
        <property type="entry name" value="Ins_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCG28260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="ZK1251.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2S9"/>
        </source>
    </evidence>
    <sequence length="116" mass="13609" checksum="7308E6EC5586A507" modified="2012-05-16" version="1">MYKVHYFLINTMPPIILVFFLVLIPASQQYPFSLESLNDQIINEEVIEYMLENSIRSSRTRRVPDEKKIYRCGRRIHSYVFAVCGKACESNTEVNIASKCCREECTDDFIRKQCCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2T0</accession>
    <name>H9G2T0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nhr-11</name>
        <name evidence="5" type="ORF">CELE_ZC410.1</name>
        <name evidence="7" type="ORF">ZC410.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255360.1">
        <property type="nucleotide sequence ID" value="NM_001268431.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2T0"/>
    <dbReference type="SMR" id="H9G2T0"/>
    <dbReference type="GeneID" id="177724"/>
    <dbReference type="AGR" id="WB:WBGene00003610"/>
    <dbReference type="CTD" id="177724"/>
    <dbReference type="WormBase" id="ZC410.1e">
        <property type="protein sequence ID" value="CE47436"/>
        <property type="gene ID" value="WBGene00003610"/>
        <property type="gene designation" value="nhr-11"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007368_17_0_1"/>
    <dbReference type="OrthoDB" id="9996608at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003610">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2T0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011:SF27">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-86-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="6"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCG28237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="ZC410.1e"/>
        </source>
    </evidence>
    <sequence length="277" mass="32630" checksum="A43B21CD246638E3" modified="2012-05-16" version="1">MLYSIENNSILQYYHSMETGLCSKRRIMYTNTGMDFILDTHANLQCPFTVNDLRPHDYRNFRGMLRHDFVMLFDYATRFPEFNSFTSHEKNMFYRQIVAVDFILSSAYYTAKLGQAHRQMVLTNGEYLNMDPLPMSGNEIDARRYFDCDEDFSKYRALMPMHIAIWEESIVPFSKLNVTFEEFCLLKALTVWQATYFKLTENGREKCRRQRNIIIGFLSKMCHSPGGGGEHRVGELLMSMNYLRESAQKLTTSYVMLTVFNVLNCDSMLHEMLNFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2T1</accession>
    <name>H9G2T1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear hormone receptor family member nhr-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">nhr-11</name>
        <name evidence="15" type="ORF">CELE_ZC410.1</name>
        <name evidence="17" type="ORF">ZC410.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255359.1">
        <property type="nucleotide sequence ID" value="NM_001268430.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2T1"/>
    <dbReference type="GeneID" id="177724"/>
    <dbReference type="AGR" id="WB:WBGene00003610"/>
    <dbReference type="CTD" id="177724"/>
    <dbReference type="WormBase" id="ZC410.1d">
        <property type="protein sequence ID" value="CE03805"/>
        <property type="gene ID" value="WBGene00003610"/>
        <property type="gene designation" value="nhr-11"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9996608at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003610">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2T1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="131"/>
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            <begin position="94"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="RuleBase" id="RU004334"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS51030"/>
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            <dbReference type="PROSITE" id="PS51843"/>
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            <dbReference type="EMBL" id="CCG28238.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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            <dbReference type="WormBase" id="ZC410.1d"/>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCG28102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F59B8.2c"/>
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    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2T3"/>
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    <sequence length="47" mass="5145" checksum="C7037A6CE71FCABA" modified="2012-05-16" version="1">MEAGFLTKDLAICVKGGNASAVTRTDYLNTFEFLDKLAENLAKKQAH</sequence>
</entry>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28163.1"/>
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    <dbReference type="CTD" id="177846"/>
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    <dbReference type="Proteomes" id="UP000001940">
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="542"/>
        </location>
    </feature>
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        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F25H8.5h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2T6"/>
        </source>
    </evidence>
    <sequence length="542" mass="52734" checksum="BBC0D903B1591AA0" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2T7</accession>
    <name>H9G2T7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">dur-1</name>
        <name evidence="3" type="ORF">CELE_F25H8.5</name>
        <name evidence="5" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255433.1">
        <property type="nucleotide sequence ID" value="NM_001268504.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2T7"/>
    <dbReference type="SMR" id="H9G2T7"/>
    <dbReference type="PeptideAtlas" id="H9G2T7"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5j">
        <property type="protein sequence ID" value="CE47174"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2T7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003619614" evidence="2">
        <location>
            <begin position="18"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F25H8.5j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2T7"/>
        </source>
    </evidence>
    <sequence length="520" mass="50315" checksum="C7542B49ABCBFE70" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2T8</accession>
    <name>H9G2T8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">dur-1</name>
        <name evidence="1" type="ORF">CELE_F25H8.5</name>
        <name evidence="3" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380114.1">
        <property type="nucleotide sequence ID" value="NM_001392376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2T8"/>
    <dbReference type="PeptideAtlas" id="H9G2T8"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5o">
        <property type="protein sequence ID" value="CE47468"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2T8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F25H8.5o"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2T8"/>
        </source>
    </evidence>
    <sequence length="267" mass="24469" checksum="656EBC4538DE3356" modified="2012-05-16" version="1">MRMVGENVAHGAGKVADGAKAAGNYAVDSANTAGEAIVDGAKTVGQTASDGMRMIGENVAHGAGVVVEGAKSAGQSIADGAVAAKDAAVEGATTAGNKTVEGMRFVGENVAHGAGKVADGAKAAGDTVVEGGKAAAEKTESGIAFVGQKIAEGAGAVAGGAKAAGGAVVDGVAAAGGAVVGGAKAVGSGIADGAKFVGENVAYGAGAVAGGAKAAGGAVVDGAAAAGGAVVDGAKAVGGFVSDTFSSARDETGEALKTAGSKVKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2T9</accession>
    <name>H9G2T9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">dur-1</name>
        <name evidence="2" type="ORF">CELE_F25H8.5</name>
        <name evidence="4" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255438.1">
        <property type="nucleotide sequence ID" value="NM_001268509.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2T9"/>
    <dbReference type="PeptideAtlas" id="H9G2T9"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5l">
        <property type="protein sequence ID" value="CE47400"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1333000_0_0_1"/>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2T9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F25H8.5l"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2T9"/>
        </source>
    </evidence>
    <sequence length="206" mass="18830" checksum="B92704AD9211B3AE" modified="2012-05-16" version="1">MYDAAAEGASNMAQSMHEAGKSTGDALSEGAEAGYDAVKDGGRWVGENVAHGAGKVADGAKAAGDTVVEGGKAAAEKTESGIAFVGQKIAEGAGAVAGGAKAAGGAVVDGVAAAGGAVVGGAKAVGSGIADGAKFVGENVAYGAGAVAGGAKAAGGAVVDGAAAAGGAVVDGAKAVGGFVSDTFSSARDETGEALKTAGSKVKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2U0</accession>
    <name>H9G2U0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">dur-1</name>
        <name evidence="1" type="ORF">CELE_F25H8.5</name>
        <name evidence="3" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368122.1">
        <property type="nucleotide sequence ID" value="NM_001380423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2U0"/>
    <dbReference type="PeptideAtlas" id="H9G2U0"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5r">
        <property type="protein sequence ID" value="CE47279"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2075267_0_0_1"/>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2U0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F25H8.5r"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2U0"/>
        </source>
    </evidence>
    <sequence length="118" mass="11835" checksum="582FD0BCAE9DF4A0" modified="2012-05-16" version="1">MRMVGENVAHGAGKVADGAKAAGNYAVDSANTAGEAIVDGAKTVGQTASDGMRMIGENVAHGAGVVVEGAKSAGEQTVEGAKSGARWVGENVAHGAGKVADGASKFFTTFFNERFLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2U1</accession>
    <name>H9G2U1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">dur-1</name>
        <name evidence="2" type="ORF">CELE_F25H8.5</name>
        <name evidence="4" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370882.1">
        <property type="nucleotide sequence ID" value="NM_001383173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2U1"/>
    <dbReference type="PeptideAtlas" id="H9G2U1"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5m">
        <property type="protein sequence ID" value="CE47222"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2U1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F25H8.5m"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2U1"/>
        </source>
    </evidence>
    <sequence length="166" mass="15203" checksum="AB050C515B3EC3B4" modified="2012-05-16" version="1">MYDAAAEGASNMAQSMHEAGKSTGDALSEGAEAGYDAVKDGGRWVGENVAHGAGKVADGAKAAGGAVVDGVAAAGGAVVGGAKAVGSGIADGAKFVGENVAYGAGAVAGGAKAAGGAVVDGAAAAGGAVVDGAKAVGGFVSDTFSSARDETGEALKTAGSKVKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2U3</accession>
    <name>H9G2U3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">dur-1</name>
        <name evidence="1" type="ORF">CELE_F25H8.5</name>
        <name evidence="3" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255440.1">
        <property type="nucleotide sequence ID" value="NM_001268511.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2U3"/>
    <dbReference type="PeptideAtlas" id="H9G2U3"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5n">
        <property type="protein sequence ID" value="CE47332"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1612305_0_0_1"/>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2U3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F25H8.5n"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2U3"/>
        </source>
    </evidence>
    <sequence length="165" mass="14801" checksum="1D22CEBA8B733DEE" modified="2012-05-16" version="1">MRMVGENVAHGAGKVADGAKAAGDTVVEGGKAAAEKTESGIAFVGQKIAEGAGAVAGGAKAAGGAVVDGVAAAGGAVVGGAKAVGSGIADGAKFVGENVAYGAGAVAGGAKAAGGAVVDGAAAAGGAVVDGAKAVGGFVSDTFSSARDETGEALKTAGSKVKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2U4</accession>
    <name>H9G2U4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">dur-1</name>
        <name evidence="3" type="ORF">CELE_F25H8.5</name>
        <name evidence="5" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255446.1">
        <property type="nucleotide sequence ID" value="NM_001268517.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2U4"/>
    <dbReference type="SMR" id="H9G2U4"/>
    <dbReference type="PeptideAtlas" id="H9G2U4"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5g">
        <property type="protein sequence ID" value="CE47359"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039440_0_0_1"/>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2U4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003619607" evidence="2">
        <location>
            <begin position="18"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F25H8.5g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2U4"/>
        </source>
    </evidence>
    <sequence length="392" mass="43344" checksum="155384F0BF3EAA50" modified="2012-05-16" version="1">MRTLFILVSLCAALCFSAPVSEQDLRVRRNAEEAAHSGAEAVVHILQPVKTYVYTATGEFVVTQLAEKHTLRVAARLETQNDRLKRQQSAEERARAEADARRRERCRNRRPQPTPGPPPPRNNCLPPPGPPPPCQQYQQPQPPPCQRPQPPQPQPQPYPQRTGGCLPSPRGYENQPQPPQPQQQQYPQPQPQRGGCTYSQPQPQPQQQPQPPCYQRQPEPPRQTGGCLPGPYYSPNTMAPPQHQQPYPERNGGGCRQRSPQPQYPRTNEFRAPVVECHGNGPAPCNPQPQQEDPCVGKVNIVSVDAAGKVDHYLYETKKQSGDVIGEASNKVSETAEQGAHWTGDRAREAGNTLSNAAHDGYEQGRDGVADMRERIDEAGHEVAEAAEEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2U5</accession>
    <name>H9G2U5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">dur-1</name>
        <name evidence="1" type="ORF">CELE_F25H8.5</name>
        <name evidence="3" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360167.1">
        <property type="nucleotide sequence ID" value="NM_001372910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2U5"/>
    <dbReference type="PeptideAtlas" id="H9G2U5"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5p">
        <property type="protein sequence ID" value="CE47154"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1042913_0_0_1"/>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2U5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F25H8.5p"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2U5"/>
        </source>
    </evidence>
    <sequence length="249" mass="22850" checksum="C5B8A92E52641DC8" modified="2012-05-16" version="1">MRMVGENVAHGAGKVADGAKAAGNYAVDSANTAGEAIVDGAKTVGQTASDGMRMIGENVAHGAGVVVEGAKSAGEQTVEGAKSGARWVGENVAHGAGKVADGAKAAGDTVVEGGKAAAEKTESGIAFVGQKIAEGAGAVAGGAKAAGGAVVDGVAAAGGAVVGGAKAVGSGIADGAKFVGENVAYGAGAVAGGAKAAGGAVVDGAAAAGGAVVDGAKAVGGFVSDTFSSARDETGEALKTAGSKVKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2U6</accession>
    <name>H9G2U6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">dur-1</name>
        <name evidence="3" type="ORF">CELE_F25H8.5</name>
        <name evidence="5" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255435.1">
        <property type="nucleotide sequence ID" value="NM_001268506.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2U6"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5i">
        <property type="protein sequence ID" value="CE47088"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2U6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003620728" evidence="2">
        <location>
            <begin position="18"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F25H8.5i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2U6"/>
        </source>
    </evidence>
    <sequence length="543" mass="52904" checksum="0EA13FBDFDB6E4F1" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2U7</accession>
    <name>H9G2U7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">dur-1</name>
        <name evidence="1" type="ORF">CELE_F25H8.5</name>
        <name evidence="3" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370883.1">
        <property type="nucleotide sequence ID" value="NM_001383175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2U7"/>
    <dbReference type="PeptideAtlas" id="H9G2U7"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5q">
        <property type="protein sequence ID" value="CE47228"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1751416_0_0_1"/>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2U7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F25H8.5q"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2U7"/>
        </source>
    </evidence>
    <sequence length="155" mass="14802" checksum="1057FBB0863788BF" modified="2012-05-16" version="1">MRMVGENVAHGAGKVADGAKAAGNYAVDSANTAGEAIVDGAKTVGQTASDGMRMIGENVAHGAGVVVEGAKSAGEQTVEGAKSGARWVGENVAHGAGKVADGAKSAGQSIADGAVAAKDAAVEGATTAGNKTVEGMRFVGENVAHGAGKVADGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2U8</accession>
    <name>H9G2U8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Movement protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">B0001.7</name>
        <name evidence="2" type="ORF">CELE_B0001.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255629.1">
        <property type="nucleotide sequence ID" value="NM_001268700.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2U8"/>
    <dbReference type="GeneID" id="178165"/>
    <dbReference type="AGR" id="WB:WBGene00007092"/>
    <dbReference type="CTD" id="178165"/>
    <dbReference type="WormBase" id="B0001.7c">
        <property type="protein sequence ID" value="CE47208"/>
        <property type="gene ID" value="WBGene00007092"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372657_0_0_1"/>
    <dbReference type="OrthoDB" id="5780504at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007092">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2U8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="B0001.7c"/>
        </source>
    </evidence>
    <sequence length="121" mass="13403" checksum="6C3EE21DC64C1F61" modified="2012-05-16" version="1">MLNRNTYTSKNFPIIFDADGIIKNPIPGAIYCVVILRKKIQVTQTESPTHKYQWIIDSAQSNPFIITEYYNPHNAFNRSFIASKQFSSSAALSTDSKKGSSGSEKSSTSPPLKSLTPPSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>H9G326</accession>
    <name>H9G326_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CUB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">irg-6</name>
        <name evidence="6" type="ORF">C32H11.1</name>
        <name evidence="4" type="ORF">CELE_C32H11.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255688.1">
        <property type="nucleotide sequence ID" value="NM_001268759.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G326"/>
    <dbReference type="SMR" id="H9G326"/>
    <dbReference type="PeptideAtlas" id="H9G326"/>
    <dbReference type="GeneID" id="183126"/>
    <dbReference type="AGR" id="WB:WBGene00007864"/>
    <dbReference type="CTD" id="183126"/>
    <dbReference type="WormBase" id="C32H11.1b">
        <property type="protein sequence ID" value="CE19708"/>
        <property type="gene ID" value="WBGene00007864"/>
        <property type="gene designation" value="irg-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040706_0_0_1"/>
    <dbReference type="OrthoDB" id="5848077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007864">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G326">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003366">
        <property type="entry name" value="CUB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056014">
        <property type="entry name" value="DUF7592"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47919:SF2">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47919">
        <property type="entry name" value="INFECTION RESPONSE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02408">
        <property type="entry name" value="CUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24512">
        <property type="entry name" value="DUF7592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003619129" evidence="1">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="CUB-like" evidence="2">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7592" evidence="3">
        <location>
            <begin position="159"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCG28075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C32H11.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H9G326"/>
        </source>
    </evidence>
    <sequence length="462" mass="52124" checksum="2B7C1E746A975558" modified="2012-05-16" version="1">MLSTVFLLATLAASAAADGYSCARNTLINPPQDLSKPYYYPETWRENMEPPQYAPNQKCNWKINVPQGMYATVIFYKKTKYEIGIQCAYPGKDLEYINDYEQSPYIFTSPQFQVDLKVGDKPGAFSFKVVWSKYPPGSAMNIELDGIHSISGVASSFYTTYTAINQVMIVGFSVPDVDTNLLRQSAIYDGDSVNAKFLGNLFDALEGQIVSTGNKLTIYTFGLENQVDNTLFMGLDTKAAGDIEQYTGLNCPVDRTRGCSIILHSYFYATAEARISRQPDYLMLPDSFPYNATLKIYGETLQDSSLFAAVNKSNYQTMFPMKVTNSLKIYHLDHDIVSIDVTNNADEAKWSTVYDGRNIKVQSMDYGRTSFYQDTMETFTTEPNTQMYFKFNVKYFDVNGPTSLAIKVYNNAKIVYSETYTATNLPTPYNVRVYGDKMDINYQTFGNYTQGFEVNIVTTKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>H9G329</accession>
    <name>H9G329_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">kin-4</name>
        <name evidence="18" type="ORF">C10C6.1</name>
        <name evidence="16" type="ORF">CELE_C10C6.1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255554.1">
        <property type="nucleotide sequence ID" value="NM_001268625.3"/>
    </dbReference>
    <dbReference type="SMR" id="H9G329"/>
    <dbReference type="GeneID" id="178068"/>
    <dbReference type="AGR" id="WB:WBGene00002192"/>
    <dbReference type="CTD" id="178068"/>
    <dbReference type="WormBase" id="C10C6.1e">
        <property type="protein sequence ID" value="CE47411"/>
        <property type="gene ID" value="WBGene00002192"/>
        <property type="gene designation" value="kin-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10070999at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002192">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G329">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06705">
        <property type="entry name" value="PDZ_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000457">
        <property type="entry name" value="Microtubule-associated serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF414">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
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    <sequence length="1649" mass="178753" checksum="F649311A807E16ED" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>H9G330</accession>
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        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
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</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>H9G331</accession>
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            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Nematoda</taxon>
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            <taxon>Rhabditoidea</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCG28214.1"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">Bristol N2</strain>
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    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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            <end position="188"/>
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    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="9">
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    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="9">
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            <begin position="1421"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="9">
        <location>
            <begin position="1485"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="9">
        <location>
            <begin position="1986"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="9">
        <location>
            <begin position="2315"/>
            <end position="2372"/>
        </location>
    </feature>
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        <location>
            <begin position="390"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="775"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
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        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51162"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCG28203.1"/>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>H9G335</accession>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
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    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditoidea</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <sequence length="315" mass="34510" checksum="769938F48FD27192" modified="2012-05-16" version="1">MISLFFKRAMSTNPIVTPQWLMQNVNKVRLIDATYAPTATRDYKEFKTKCYGNFDLLTKNNTVAAYTGEHIPGAAHFGLDSAYFPSQYIKFDLYPPEHFEKYLRLLGINNDEQVVIYSRGPAAGMMFASRAYWTLKAYGLTNLSLLNGGLDAWKAAGGPTDNSVVTPKLGNVNVKSLDNTILAKFEEIPFNEFAENKVDYLDARTTPQFTGEEPLNKTFPDTKATGSHVTGAISFPMAKVIGPDGFISQQDVDAQIANLGLKSGNQVYVACNTGIQASVIFVALERSGIKAKLYNGSMTELASRAPELVNATGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H9G344</accession>
    <name>H9G344_CAEEL</name>
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        <submittedName>
            <fullName evidence="6">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">glb-22</name>
        <name evidence="6" type="ORF">CELE_R11H6.3</name>
        <name evidence="8" type="ORF">R11H6.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256602.1">
        <property type="nucleotide sequence ID" value="NM_001269673.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G344"/>
    <dbReference type="SMR" id="H9G344"/>
    <dbReference type="GeneID" id="187832"/>
    <dbReference type="AGR" id="WB:WBGene00011251"/>
    <dbReference type="CTD" id="187832"/>
    <dbReference type="WormBase" id="R11H6.3b">
        <property type="protein sequence ID" value="CE47200"/>
        <property type="gene ID" value="WBGene00011251"/>
        <property type="gene designation" value="glb-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863194at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011251">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G344">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF18">
        <property type="entry name" value="GLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="70"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCG28263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="R11H6.3b"/>
        </source>
    </evidence>
    <sequence length="320" mass="35683" checksum="63ADAD08F7C256B4" modified="2012-05-16" version="1">MMGAARAGFYKKRVSNPMLTPKKKRNSSASVTSSPARSTTNRLAVPNPPLRKRSGSAPSIKLITLASIWNLKHEHIRALKTTWARLCEPPRANCKGIVSLVERVWEKLDTKDKDVRNIFYNAAFVDSMHERRSGSIATLRDHTHFFVSLVSQVVSSLEKEPAKILEHLDHIGQSHAYLKRYGFKSSHWEKVGEYFVDHVVIQDCVRGFPEACRAWTVLVSSIVDRLRAAPRRGSFLNSPSSSRRGSMCTSSQLSINDEAPKCPFMSKSANNSVTRLSCSESVSRRGSIVLPATTIDMSTLKDALPTPPHNLHQNNNHVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>H9G345</accession>
    <name>H9G345_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">glb-22</name>
        <name evidence="5" type="ORF">CELE_R11H6.3</name>
        <name evidence="7" type="ORF">R11H6.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256601.1">
        <property type="nucleotide sequence ID" value="NM_001269672.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G345"/>
    <dbReference type="SMR" id="H9G345"/>
    <dbReference type="GeneID" id="187832"/>
    <dbReference type="AGR" id="WB:WBGene00011251"/>
    <dbReference type="CTD" id="187832"/>
    <dbReference type="WormBase" id="R11H6.3a">
        <property type="protein sequence ID" value="CE47246"/>
        <property type="gene ID" value="WBGene00011251"/>
        <property type="gene designation" value="glb-22"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842606_0_0_1"/>
    <dbReference type="OrthoDB" id="5863194at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011251">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G345">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF18">
        <property type="entry name" value="GLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCG28264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="R11H6.3a"/>
        </source>
    </evidence>
    <sequence length="324" mass="36228" checksum="A5C9B762C443893C" modified="2012-05-16" version="1">MMGAARAGFYKKRVSNPMLTPKKKRNSSASVTSSPARSTTNRLAVPNPPLRKRSGSAPSIKLITLASIWNLKHEHIRALKTTWARLCEPPRANCKGIVSLVERVWEKLDTKDKDVRNIFYNAAFVDSMHERCERRRSGSIATLRDHTHFFVSLVSQVVSSLEKEPAKILEHLDHIGQSHAYLKRYGFKSSHWEKVGEYFVDHVVIQDCVRGFPEACRAWTVLVSSIVDRLRAAPRRGSFLNSPSSSRRGSMCTSSQLSINDEAPKCPFMSKSANNSVTRLSCSESVSRRGSIVLPATTIDMSTLKDALPTPPHNLHQNNNHVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H9G346</accession>
    <name>H9G346_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_T10C6.15</name>
        <name evidence="1 3" type="ORF">T10C6.15</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256695.1">
        <property type="nucleotide sequence ID" value="NM_001269766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G346"/>
    <dbReference type="GeneID" id="13217259"/>
    <dbReference type="AGR" id="WB:WBGene00050899"/>
    <dbReference type="CTD" id="13217259"/>
    <dbReference type="WormBase" id="T10C6.15c">
        <property type="protein sequence ID" value="CE47253"/>
        <property type="gene ID" value="WBGene00050899"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030831_0_2_1"/>
    <dbReference type="OrthoDB" id="5793453at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00050899">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G346">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T10C6.15c"/>
        </source>
    </evidence>
    <sequence length="40" mass="4781" checksum="5759B2930F411C83" modified="2012-05-16" version="1">MWIFEIPKTDKSILLVHYASRTFRFSKILSSSVEICQNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H9G347</accession>
    <name>H9G347_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T10C6.15</name>
        <name evidence="2 4" type="ORF">T10C6.15</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001269767.1"/>
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        <property type="protein sequence ID" value="CE47375"/>
        <property type="gene ID" value="WBGene00050899"/>
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        <property type="entry name" value="DUF38/FTH_CAE_spp"/>
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        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR23015">
        <property type="entry name" value="UNCHARACTERIZED C.ELEGANS PROTEIN"/>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
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    <sequence length="253" mass="29119" checksum="6454D3870C8549D0" modified="2012-05-16" version="1">MLCKKLSIADMPDLVCENIFRQLDFRSLSTIPHLCKRFQNVFSALQLEIHLESITITIGSYCINIYMDPYNDWTMDIEYHQKDNGCLVRSGNSEKFLEDENSTRLFCDDFGRNVRNQKKPLKMLRLNLENEFENENDNAKLLGSLQSTLISRKPLLKVDELSISSTSISSILPCIDSKSLKKLAIEGSSDQIQDEITNIDEIVQLEQWANLEELVARDFFLRIPVKFLRHFSKIDVSLKSISAMDLCDLKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>H9G348</accession>
    <name>H9G348_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Basement membrane proteoglycan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">unc-52</name>
        <name evidence="19" type="ORF">CELE_ZC101.2</name>
        <name evidence="21" type="ORF">ZC101.2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCG28426.1"/>
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        <property type="gene ID" value="WBGene00006787"/>
        <property type="gene designation" value="unc-52"/>
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        <property type="component" value="Chromosome II"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
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        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
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        <property type="entry name" value="LDL_receptor-like_sf"/>
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        <property type="entry name" value="LE_dom"/>
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        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
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        <property type="entry name" value="BASIGIN RELATED"/>
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        <property type="entry name" value="FASCICLIN-2"/>
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        <property type="entry name" value="EGF_LMN_ATRN"/>
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        <property type="entry name" value="Ldl_recept_a"/>
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        <property type="entry name" value="LDLRECEPTOR"/>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="8 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 13" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
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    </feature>
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    </feature>
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            <end position="2048"/>
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            <begin position="2074"/>
            <end position="2161"/>
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            <begin position="2250"/>
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        <location>
            <begin position="364"/>
            <end position="385"/>
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        <location>
            <begin position="1388"/>
            <end position="1426"/>
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            <begin position="1478"/>
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        <location>
            <begin position="2341"/>
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        <location>
            <begin position="369"/>
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            <begin position="1388"/>
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        <location>
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            <begin position="2341"/>
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        <source>
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        <source>
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    <sequence length="2383" mass="260372" checksum="454B5D21713D1D02" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>H9G349</accession>
    <name>H9G349_CAEEL</name>
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        <submittedName>
            <fullName evidence="19">Basement membrane proteoglycan</fullName>
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        <name evidence="19 21" type="primary">unc-52</name>
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        <name evidence="21" type="ORF">ZC101.2</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
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    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 13" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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            <end position="1004"/>
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            <end position="1060"/>
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            <end position="1222"/>
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            <begin position="1226"/>
            <end position="1311"/>
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    <feature type="domain" description="Ig-like" evidence="17">
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            <begin position="1319"/>
            <end position="1401"/>
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    <feature type="domain" description="Ig-like" evidence="17">
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    <feature type="domain" description="Ig-like" evidence="17">
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    <feature type="domain" description="Ig-like" evidence="17">
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            <begin position="1699"/>
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            <end position="2341"/>
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            <end position="385"/>
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    <sequence length="2388" mass="260944" checksum="D06EABEB61804740" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>H9G350</accession>
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        <submittedName>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19 20">Bristol N2</strain>
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        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="LDLRECEPTOR"/>
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        <property type="match status" value="6"/>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="16"/>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="16"/>
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        <property type="entry name" value="LamB"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="3"/>
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        <property type="match status" value="14"/>
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        <property type="match status" value="3"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
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    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
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        <location>
            <begin position="1"/>
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        <source>
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        <source>
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        <source>
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    <sequence length="2479" mass="271057" checksum="25C3F53540997FDE" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>H9G351</accession>
    <name>H9G351_CAEEL</name>
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        <submittedName>
            <fullName evidence="19">Basement membrane proteoglycan</fullName>
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        <name evidence="19 21" type="primary">unc-52</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19 20">Bristol N2</strain>
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        <subcellularLocation>
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    </comment>
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        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="entry name" value="Terribly reduced optic lobes, isoform AI"/>
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        <property type="entry name" value="EGF-type module"/>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="Laminin_IV"/>
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        <property type="entry name" value="LDL_receptor-like_sf"/>
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    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
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        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
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        <property type="entry name" value="LE_dom"/>
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        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
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        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEPARAN SULFATE PROTEOGLYCAN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="4"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="5"/>
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        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
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    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="6"/>
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    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="14"/>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="14"/>
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        <property type="entry name" value="LamB"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
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    <dbReference type="SUPFAM" id="SSF57196">
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        <property type="match status" value="3"/>
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        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0964">Secreted</keyword>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CCG28429.1"/>
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        <source>
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        <source>
            <dbReference type="WormBase" id="ZC101.2k"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="2296" mass="250395" checksum="4A018183851C3E5B" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>H9G352</accession>
    <name>H9G352_CAEEL</name>
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        <submittedName>
            <fullName evidence="19">Basement membrane proteoglycan</fullName>
        </submittedName>
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        <name evidence="19 21" type="primary">unc-52</name>
        <name evidence="19" type="ORF">CELE_ZC101.2</name>
        <name evidence="21" type="ORF">ZC101.2</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="project" value="UniProtKB-ARBA"/>
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</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>H9G353</accession>
    <name>H9G353_CAEEL</name>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
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    </reference>
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            <location evidence="1">Extracellular matrix</location>
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        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <evidence type="ECO:0000256" key="15">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCG28431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
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    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PeptideAtlas" id="H9G353"/>
        </source>
    </evidence>
    <sequence length="2196" mass="240516" checksum="D86C3BD16DEF2127" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>H9G354</accession>
    <name>H9G354_CAEEL</name>
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        <submittedName>
            <fullName evidence="19">Basement membrane proteoglycan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">unc-52</name>
        <name evidence="19" type="ORF">CELE_ZC101.2</name>
        <name evidence="21" type="ORF">ZC101.2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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    <proteinExistence type="evidence at protein level"/>
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            <dbReference type="EMBL" id="CCG28188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="H09F14.1d"/>
        </source>
    </evidence>
    <sequence length="319" mass="36386" checksum="CC8D0A56E5E74D15" modified="2012-05-16" version="1">MEETGFQFDVYMYLLPLIVIFGLSGNVISLVTIFHSRLRRVNANIYLIVLTLADSIFLTGILLICFKVDWIAYEYCVGLEYVLMTASYISSWSTAALTIERYLAIAHPLSHMKYGHVDRAKVMLYWVPIPFVLQLFQFFSLEPATEERKCALKEANYQIIAQAVDTVLCYVVPCGIIVVLNILVALQVQKSQEHFMAETKKSNSRRTGGSSSSSGTWTRILWVMPLVFVVLNTPFYVIMMIEIVFQIIYQSPPSGDTRSELFVTVYNTAHYMYYMNTAIDVLVYAFSSANFRKTAVIAWKRILCPGYAERQKGKVITSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>H9G357</accession>
    <name>H9G357_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CELE_H09F14.1</name>
        <name evidence="11 13" type="ORF">H09F14.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256230.1">
        <property type="nucleotide sequence ID" value="NM_001269301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G357"/>
    <dbReference type="SMR" id="H9G357"/>
    <dbReference type="GeneID" id="186709"/>
    <dbReference type="KEGG" id="cel:CELE_H09F14.1"/>
    <dbReference type="AGR" id="WB:WBGene00010375"/>
    <dbReference type="CTD" id="186709"/>
    <dbReference type="WormBase" id="H09F14.1e">
        <property type="protein sequence ID" value="CE47091"/>
        <property type="gene ID" value="WBGene00010375"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010375">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G357">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF100">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="77"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCG28189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="H09F14.1e"/>
        </source>
    </evidence>
    <sequence length="328" mass="37109" checksum="96120BB65106F06E" modified="2012-05-16" version="1">MEETGFQFDVYMYLLPLIVIFGLSGNVISLVTIFHSRLRRYGHVDRAKVMLYWVPIPFVLQLFQFFSLEPATEERKCALKEANYQIIAQAVDTVLCYVVPCGIIVVLNILVALQVQKSQEHFMAETKKSNSRRTGGSSSSSGTWTRILWVMPLVFVVLNTPFYVIMMIEIVFQIIYQSPPSGDTRSELFVTVYNTAHYMYYMNTAIDVLVYAFSSANFRKTAVIAWKRILCPGYAERQKGKRFLLSMVHSVSDSIRKRIPIAQPAPHTVLVTDQTSRISYRMTSERSTIRFPNTPSRANSPKLTASNAVSVPLLGTEIQGSSKESTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H9G363</accession>
    <name>H9G363_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Domain of unknown function DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y57G11C.42</name>
        <name evidence="4 6" type="ORF">Y57G11C.42</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255825.1">
        <property type="nucleotide sequence ID" value="NM_001268896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G363"/>
    <dbReference type="GeneID" id="3565027"/>
    <dbReference type="AGR" id="WB:WBGene00013331"/>
    <dbReference type="CTD" id="3565027"/>
    <dbReference type="WormBase" id="Y57G11C.42c">
        <property type="protein sequence ID" value="CE47259"/>
        <property type="gene ID" value="WBGene00013331"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008031_1_0_1"/>
    <dbReference type="OrthoDB" id="5872752at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013331">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G363">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF5">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003619133" description="Domain of unknown function DB domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="3">
        <location>
            <begin position="315"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCG28148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y57G11C.42c"/>
        </source>
    </evidence>
    <sequence length="419" mass="44883" checksum="338579BAAFB6E643" modified="2012-05-16" version="1">MREKYHRTFLFLIPFLISSVHCQLSCHRIPTSFCCTSRIRDQCPEQCASVQCGTDFIHSLFSTDGSRRPAPSGAHDGNANIGGTGSVDNLRSAFGSAGEPFVTSPPPAQPLFPQQTPPPPASPLISNSGDVFARSRKEISGAPDSEQQSGSAATLSGSSHEWKVSIIPRGQNKKPANVKSIPPFTIDGKADERFNKFYRTIDSVINNLDLTNGGNLHEREGEPQIRLEGSTGNSKDLSVESSAAVIVPRTTVAPGVTNKVSVIPFRPLHFTAPPRNGPPGVAPPKGAAGNEQCGVSPDFTPCVSNEIASKSLLECCKRKNLPAGCQQLCRYDITQTEIRAAMDRGQCGIFNVAPFLECASQGKDNSECCRHRGIVQKTGPQCEQFCRPAQGLSSLGVQHIVCGNAVGDMLHCHHSGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>H9G364</accession>
    <name>H9G364_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Domain of unknown function DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y57G11C.42</name>
        <name evidence="4 6" type="ORF">Y57G11C.42</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G364"/>
    <dbReference type="AGR" id="WB:WBGene00013331"/>
    <dbReference type="WormBase" id="Y57G11C.42b">
        <property type="protein sequence ID" value="CE47470"/>
        <property type="gene ID" value="WBGene00013331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013331">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G364">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF5">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003619631" description="Domain of unknown function DB domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="3">
        <location>
            <begin position="460"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCG28149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y57G11C.42b"/>
        </source>
    </evidence>
    <sequence length="564" mass="60245" checksum="7B1295CD03BC9940" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2026-01-28" version="186" xmlns="https://uniprot.org/uniprot">
    <accession>O44960-2</accession>
    <name>NHR64_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Nuclear hormone receptor family member nhr-64</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nhr-64</name>
        <name type="ORF">C45E1.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="J. Mol. Evol." volume="60" first="577" last="586">
            <title>Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes.</title>
            <authorList>
                <person name="Robinson-Rechavi M."/>
                <person name="Maina C.V."/>
                <person name="Gissendanner C.R."/>
                <person name="Laudet V."/>
                <person name="Sluder A."/>
            </authorList>
            <dbReference type="PubMed" id="15983867"/>
            <dbReference type="DOI" id="10.1007/s00239-004-0175-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O44960-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_015669"/>
        </isoform>
        <isoform>
            <id>O44960-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021043.2">
        <property type="nucleotide sequence ID" value="NM_001025872.7"/>
    </dbReference>
    <dbReference type="WormBase" id="C45E1.1b">
        <property type="protein sequence ID" value="CE39697"/>
        <property type="gene ID" value="WBGene00003654"/>
        <property type="gene designation" value="nhr-64"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="344" mass="38738" checksum="8E4F8657D00AB986" modified="2006-09-05" version="2">MTLEEKEEVSTSTSQSPQSSSFENVFCAICGDRATGKHYGAMSCDGCKAKRNSCRKCRFDVCLRKGMRRDAVQTERDRIRPANPLSNGSNGGIVPDDPLLDTLIRAEASTRGLRTTVITKTAEARKQATTNDVTDSMNQQLTLMVEWAKVLEGFQRVDNITQVALLRHFSAQHLVMCAAFRSIHLSDAVWLTNETCLHKDSPKIPDMNRVAERIIDQVTNPMRSLHMNEIEYIALKAIAFFDPLAKGITSESYSDVEEMRQRILESFERHVRYVSPYKDMPLRFANLLLLLPPMLAISRDLVEDVQLAKLFGLASIDNLMLELMLPNEGKNTTDKTSPPIMCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>O76669</accession>
    <name>O76669_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_H10E21.1</name>
        <name evidence="2 4" type="ORF">H10E21.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD68269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T33405">
        <property type="entry name" value="T33405"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O76669"/>
    <dbReference type="SMR" id="O76669"/>
    <dbReference type="UCSC" id="H10E21.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019182"/>
    <dbReference type="WormBase" id="H10E21.1a">
        <property type="protein sequence ID" value="CE32456"/>
        <property type="gene ID" value="WBGene00019182"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099986_0_0_1"/>
    <dbReference type="OrthoDB" id="5834869at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019182">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O76669">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD68269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="H10E21.1a"/>
        </source>
    </evidence>
    <sequence length="87" mass="10728" checksum="2407FCF47EC3328E" modified="2003-03-01" version="2">MAHYPLLMQLNEQLMEISRQLNSVETTNALQLKVIMHLLNRVSKRRTTWTQSICRFFRNFQFFFFAFSWPFIARLLYISYLKMMRNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q09260-2</accession>
    <name>LAG3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Protein lag-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Abnormal cell lineage protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Abnormal germline proliferation protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sel-8</name>
        <name type="synonym">lag-3</name>
        <name type="ORF">C32A3.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Nature" volume="405" first="364" last="368">
            <title>LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway.</title>
            <authorList>
                <person name="Petcherski A.G."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="10830967"/>
            <dbReference type="DOI" id="10.1038/35012645"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Proc. Natl. Acad. Sci. U.S.A." volume="97" first="7877" last="7881">
            <title>SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Doyle T.G."/>
                <person name="Wen C."/>
                <person name="Greenwald I."/>
            </authorList>
            <dbReference type="PubMed" id="10884418"/>
            <dbReference type="DOI" id="10.1073/pnas.97.14.7877"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 409-GLN--ASN-490</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2006" name="Cell" volume="124" first="985" last="996">
            <title>Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.</title>
            <authorList>
                <person name="Wilson J.J."/>
                <person name="Kovall R.A."/>
            </authorList>
            <dbReference type="PubMed" id="16530045"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.01.035"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.12 ANGSTROMS) OF 52-114 IN COMPLEX WITH LIN-12; LAG-1 AND DNA</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="EMBO J." volume="25" first="88" last="96">
            <title>LIP-1 phosphatase controls the extent of germline proliferation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lee M.H."/>
                <person name="Hook B."/>
                <person name="Lamont L.B."/>
                <person name="Wickens M."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="16319922"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600901"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="J. Biol. Chem." volume="282" first="11969" last="11981">
            <title>The notch regulator MAML1 interacts with p53 and functions as a coactivator.</title>
            <authorList>
                <person name="Zhao Y."/>
                <person name="Katzman R.B."/>
                <person name="Delmolino L.M."/>
                <person name="Bhat I."/>
                <person name="Zhang Y."/>
                <person name="Gurumurthy C.B."/>
                <person name="Germaniuk-Kurowska A."/>
                <person name="Reddi H.V."/>
                <person name="Solomon A."/>
                <person name="Zeng M.S."/>
                <person name="Kung A."/>
                <person name="Ma H."/>
                <person name="Gao Q."/>
                <person name="Dimri G."/>
                <person name="Stanculescu A."/>
                <person name="Miele L."/>
                <person name="Wu L."/>
                <person name="Griffin J.D."/>
                <person name="Wazer D.E."/>
                <person name="Band H."/>
                <person name="Band V."/>
            </authorList>
            <dbReference type="PubMed" id="17317671"/>
            <dbReference type="DOI" id="10.1074/jbc.M608974200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2020" name="Proc. Natl. Acad. Sci. U.S.A." volume="117" first="26812" last="26821">
            <title>Two classes of active transcription sites and their roles in developmental regulation.</title>
            <authorList>
                <person name="Robinson-Thiewes S."/>
                <person name="McCloskey J."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="33033228"/>
            <dbReference type="DOI" id="10.1073/pnas.2013163117"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09260-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_003908"/>
        </isoform>
        <isoform>
            <id>Q09260-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021195.1">
        <property type="nucleotide sequence ID" value="NM_001026024.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C32A3.1b">
        <property type="protein sequence ID" value="CE01505"/>
        <property type="gene ID" value="WBGene00004765"/>
        <property type="gene designation" value="sel-8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0007744" key="1">
        <source>
            <dbReference type="PDB" id="2FO1"/>
        </source>
    </evidence>
    <sequence length="468" mass="54008" checksum="B50E623F5AB4D7DB" modified="2002-06-06" version="2">MKPSTSKTTHSPPPEEPTAPFVNDNLPNPEDEPTIGDLNAFHSGEELHRQRSELARANYEKARPEMIANQRAVTAHLFNRYTEDEERKRVEQQKNKEAMNASTSAPTSSRNGGQSVENRKRRNDVVVAPPTSEEEWKRAQQQHWMGQQQPQMQFQMQQQYHSQQQQYIMMQQQHHHMTGMQQIHHQMPSTSSADSIRSVPTPASSMHQPSPAEMRNGCGMSRNATMDMTCSPMSGGQPIVDENNLAVPEGEWFDKLALAVAEQYNVDTILGPDTYDTFLAELDFSSSESPTKQSPMEMNGDRMPSTAPPPAQNPQHIAQLQQQQNKMRLMQQQQQEMQRIEQQRRQQIMQQQQQQQQQEHQRQQMLLQQQQQQQQMQQHHQMNGGGQFATQAHQQAAYMQQMQRMEQIRHQQQQAQQHQQAQQQHQQQAQHHQMGYGIPNGYPQQMHMHPPAYGAHHMPQPTAFANIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXR8</accession>
    <name>Q1ZXR8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1636 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_W09G3.1</name>
        <name evidence="1 3" type="ORF">W09G3.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ85754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXR8"/>
    <dbReference type="SMR" id="Q1ZXR8"/>
    <dbReference type="UCSC" id="W09G3.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012365"/>
    <dbReference type="WormBase" id="W09G3.1b">
        <property type="protein sequence ID" value="CE40147"/>
        <property type="gene ID" value="WBGene00012365"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1972473_0_0_1"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012365">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXR8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ85754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="W09G3.1b"/>
        </source>
    </evidence>
    <sequence length="127" mass="13761" checksum="3BC86538E44737E5" modified="2006-04-18" version="1">MHKTAKYLYIIGGCALAAEREPIRQIERIHVEKAGDSVNVISENCGQLTIARRSPACFLAGNQRILVAGGCSAPNEHTDSMEMLEISEIGEIRSIFLDEKLEIGASCSGFDWDTHSAGTVSLLILAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXR9</accession>
    <name>Q1ZXR9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anticodon-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pars-2</name>
        <name evidence="2" type="ORF">CELE_T27F6.5</name>
        <name evidence="4" type="ORF">T27F6.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ85764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040691.1">
        <property type="nucleotide sequence ID" value="NM_001047226.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXR9"/>
    <dbReference type="SMR" id="Q1ZXR9"/>
    <dbReference type="PeptideAtlas" id="Q1ZXR9"/>
    <dbReference type="GeneID" id="173117"/>
    <dbReference type="UCSC" id="T27F6.5a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004190"/>
    <dbReference type="CTD" id="173117"/>
    <dbReference type="WormBase" id="T27F6.5c">
        <property type="protein sequence ID" value="CE40134"/>
        <property type="gene ID" value="WBGene00004190"/>
        <property type="gene designation" value="pars-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_4_1_1"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004190">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXR9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000080">
        <property type="entry name" value="Prolyl Amino-acyl tRNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon-binding" evidence="1">
        <location>
            <begin position="38"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ85764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T27F6.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q1ZXR9"/>
        </source>
    </evidence>
    <sequence length="166" mass="17853" checksum="6B4F076DE531125B" modified="2006-04-18" version="1">MCCFGIGVTRLLPAAIDLLSVSDKALRLPRAIAPFDAVIIVKKSLMSNVIVEMASSSASRYLKGGILLDDRVEMSAGKRIHDANRLGIPFILVIANETERSLATQKPVIEVFTTHAKSAEPMSQGSMSLDRFVTFVQSTLYGGGGAHDSGHLAHNQVLDQLGSHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXS0</accession>
    <name>Q1ZXS0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anticodon-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pars-2</name>
        <name evidence="2" type="ORF">CELE_T27F6.5</name>
        <name evidence="4" type="ORF">T27F6.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ85763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040690.1">
        <property type="nucleotide sequence ID" value="NM_001047225.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXS0"/>
    <dbReference type="PeptideAtlas" id="Q1ZXS0"/>
    <dbReference type="GeneID" id="173117"/>
    <dbReference type="UCSC" id="T27F6.5a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004190"/>
    <dbReference type="CTD" id="173117"/>
    <dbReference type="WormBase" id="T27F6.5b">
        <property type="protein sequence ID" value="CE40133"/>
        <property type="gene ID" value="WBGene00004190"/>
        <property type="gene designation" value="pars-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_4_1_1"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004190">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXS0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ85763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T27F6.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q1ZXS0"/>
        </source>
    </evidence>
    <sequence length="114" mass="12301" checksum="05713D7DE6B90227" modified="2006-04-18" version="1">MASSSASRYLKGGILLDDRVEMSAGKRIHDANRLGIPFILVIANETERSLATQKPVIEVFTTHAKSAEPMSQGSMSLDRFVTFVQSTLYGGGGAHDSGHLAHNQVLDQLGSHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXS3</accession>
    <name>Q1ZXS3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAP-Gly domain-containing linker protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_T20F10.2</name>
        <name evidence="3 5" type="ORF">T20F10.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ85771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040686.1">
        <property type="nucleotide sequence ID" value="NM_001047221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXS3"/>
    <dbReference type="SMR" id="Q1ZXS3"/>
    <dbReference type="PeptideAtlas" id="Q1ZXS3"/>
    <dbReference type="GeneID" id="172897"/>
    <dbReference type="UCSC" id="T20F10.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011864"/>
    <dbReference type="CTD" id="172897"/>
    <dbReference type="WormBase" id="T20F10.2c">
        <property type="protein sequence ID" value="CE40125"/>
        <property type="gene ID" value="WBGene00011864"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086151_0_0_1"/>
    <dbReference type="OrthoDB" id="5857085at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011864">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXS3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ85771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T20F10.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q1ZXS3"/>
        </source>
    </evidence>
    <sequence length="153" mass="17158" checksum="CA5D262210E5D2BC" modified="2006-04-18" version="1">MQEELSALKEKAEELQRNNTALNSLVSTQAQLINQLNQTIGIIQFEKEELKNAAHLNNLTPKIEKPKDKQAEEQNAEEQHKEKEVTVTTVTTQHSREEAQVKEDNQAQSTTTVTSTESPVGKLDEKNPEIEEPEPIVAEPDAVDGDEQDDKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-18" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXS4</accession>
    <name>Q1ZXS4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine zipper protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_T20F10.2</name>
        <name evidence="4 6" type="ORF">T20F10.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ85770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1ZXS4"/>
    <dbReference type="SMR" id="Q1ZXS4"/>
    <dbReference type="UCSC" id="T20F10.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011864"/>
    <dbReference type="WormBase" id="T20F10.2b">
        <property type="protein sequence ID" value="CE13846"/>
        <property type="gene ID" value="WBGene00011864"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086151_0_0_1"/>
    <dbReference type="OrthoDB" id="5857085at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011864">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1ZXS4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004198788" evidence="3">
        <location>
            <begin position="28"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAJ85770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="T20F10.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q1ZXS4"/>
        </source>
    </evidence>
    <sequence length="262" mass="29607" checksum="6B45B09EA0F93212" modified="2006-04-18" version="1">MRNWPLFVFLICLVLFFYAFYVYQAQGEVLSQTNEEVRQLSAQLSLTKGKLVGSMADLESANSEKKSVSIQLDDITKKNEECMTSLRNTKLRVDTLEKDGKSNTDNYTKMQEELSALKEKAEELQRNNTALNSLVSTQAQLINQLNQTIGIIQFEKEELKNAAHLNNLTPKIEKPKDKQAEEQNAEEQHKEKEVTVTTVTTQHSREEAQVKEDNQAQSTTTVTSTESPVGKLDEKNPEIEEPEPIVAEPDAVDGDEQDDKET</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q21974-2</accession>
    <name>UNC8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Degenerin unc-8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Putative ligand-gated sodium channel unc-8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Uncoordinated protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">unc-8</name>
        <name evidence="1" type="ORF">R13A1.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Tavernarakis N."/>
                <person name="Shreffler W."/>
                <person name="Wang S.L."/>
                <person name="Driscoll M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="J. Neurosci." volume="0" first="0" last="0">
            <title>Transcriptional control of parallel-acting pathways that remove specific presynaptic proteins in remodeling neurons.</title>
            <authorList>
                <person name="Miller-Fleming T.W."/>
                <person name="Cuentas-Condori A."/>
                <person name="Manning L."/>
                <person name="Palumbos S."/>
                <person name="Richmond J.E."/>
                <person name="Miller D.M. III"/>
            </authorList>
            <dbReference type="PubMed" id="34045310"/>
            <dbReference type="DOI" id="10.1523/jneurosci.0893-20.2021"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21974-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q21974-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_061639"/>
        </isoform>
        <isoform>
            <id>Q21974-4</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_061638"/>
        </isoform>
        <isoform>
            <id>Q21974-3</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_061640"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001294292.1">
        <property type="nucleotide sequence ID" value="NM_001307363.3"/>
    </dbReference>
    <dbReference type="WormBase" id="R13A1.4b">
        <property type="protein sequence ID" value="CE48967"/>
        <property type="gene ID" value="WBGene00006748"/>
        <property type="gene designation" value="unc-8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="R13A1.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="R13A1.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="R13A1.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="R13A1.4d"/>
        </source>
    </evidence>
    <sequence length="776" mass="88518" checksum="735E85180E680FF6" modified="1997-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q21974-3</accession>
    <name>UNC8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Degenerin unc-8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Putative ligand-gated sodium channel unc-8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Uncoordinated protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">unc-8</name>
        <name evidence="1" type="ORF">R13A1.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Tavernarakis N."/>
                <person name="Shreffler W."/>
                <person name="Wang S.L."/>
                <person name="Driscoll M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="J. Neurosci." volume="0" first="0" last="0">
            <title>Transcriptional control of parallel-acting pathways that remove specific presynaptic proteins in remodeling neurons.</title>
            <authorList>
                <person name="Miller-Fleming T.W."/>
                <person name="Cuentas-Condori A."/>
                <person name="Manning L."/>
                <person name="Palumbos S."/>
                <person name="Richmond J.E."/>
                <person name="Miller D.M. III"/>
            </authorList>
            <dbReference type="PubMed" id="34045310"/>
            <dbReference type="DOI" id="10.1523/jneurosci.0893-20.2021"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21974-3</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_061640"/>
        </isoform>
        <isoform>
            <id>Q21974-4</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_061638"/>
        </isoform>
        <isoform>
            <id>Q21974-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q21974-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_061639"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001294293.1">
        <property type="nucleotide sequence ID" value="NM_001307364.3"/>
    </dbReference>
    <dbReference type="WormBase" id="R13A1.4c">
        <property type="protein sequence ID" value="CE49123"/>
        <property type="gene ID" value="WBGene00006748"/>
        <property type="gene designation" value="unc-8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="R13A1.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="R13A1.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="R13A1.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="R13A1.4d"/>
        </source>
    </evidence>
    <sequence length="778" mass="89334" checksum="89762F89C2F4471A" modified="1997-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q21974-4</accession>
    <name>UNC8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of Degenerin unc-8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Putative ligand-gated sodium channel unc-8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Uncoordinated protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">unc-8</name>
        <name evidence="1" type="ORF">R13A1.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Tavernarakis N."/>
                <person name="Shreffler W."/>
                <person name="Wang S.L."/>
                <person name="Driscoll M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="J. Neurosci." volume="0" first="0" last="0">
            <title>Transcriptional control of parallel-acting pathways that remove specific presynaptic proteins in remodeling neurons.</title>
            <authorList>
                <person name="Miller-Fleming T.W."/>
                <person name="Cuentas-Condori A."/>
                <person name="Manning L."/>
                <person name="Palumbos S."/>
                <person name="Richmond J.E."/>
                <person name="Miller D.M. III"/>
            </authorList>
            <dbReference type="PubMed" id="34045310"/>
            <dbReference type="DOI" id="10.1523/jneurosci.0893-20.2021"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21974-4</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_061638"/>
        </isoform>
        <isoform>
            <id>Q21974-3</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_061640"/>
        </isoform>
        <isoform>
            <id>Q21974-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_061639"/>
        </isoform>
        <isoform>
            <id>Q21974-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001294294.1">
        <property type="nucleotide sequence ID" value="NM_001307365.3"/>
    </dbReference>
    <dbReference type="WormBase" id="R13A1.4d">
        <property type="protein sequence ID" value="CE04840"/>
        <property type="gene ID" value="WBGene00006748"/>
        <property type="gene designation" value="unc-8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="R13A1.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="R13A1.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="R13A1.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="R13A1.4d"/>
        </source>
    </evidence>
    <sequence length="737" mass="84382" checksum="59FBB861F45E0AB9" modified="1997-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="175" xmlns="https://uniprot.org/uniprot">
    <accession>Q27474-2</accession>
    <name>DNLI1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of DNA ligase 1</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>DNA ligase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Polydeoxyribonucleotide synthase [ATP] 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">lig-1</name>
        <name type="ORF">C29A12.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q27474-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q27474-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_013779 VSP_013778"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_741626.2">
        <property type="nucleotide sequence ID" value="NM_171538.6"/>
    </dbReference>
    <dbReference type="WormBase" id="C29A12.3b">
        <property type="protein sequence ID" value="CE37481"/>
        <property type="gene ID" value="WBGene00002985"/>
        <property type="gene designation" value="lig-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10135"/>
        </source>
    </evidence>
    <sequence length="210" mass="22716" checksum="7384B3AB04FDDF68" modified="2005-05-24" version="2">MFFSKAGKAAVEWAKGSKVPYKEFALTLEKIEELSGKKKVDELAQFFTKVLDFSPDDLTACVYMSVNQLGPSYEGLELGVAENSLIKAVAKATGRTEGKIKEDLRAKGDLGTVAQQSRSNQKMLAVPKALTVPTVFNKLTEIAKLSGTSAMNKKVDAISALLIACQGIEARFLVRMLAGKMRIGLGEQSVLSALGHAFTLSKITDQKRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-01-10" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q2V4Y0</accession>
    <name>Q2V4Y0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_ZK353.10</name>
        <name evidence="2 4" type="ORF">ZK353.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040895.1">
        <property type="nucleotide sequence ID" value="NM_001047430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2V4Y0"/>
    <dbReference type="SMR" id="Q2V4Y0"/>
    <dbReference type="GeneID" id="4363052"/>
    <dbReference type="KEGG" id="cel:CELE_ZK353.10"/>
    <dbReference type="UCSC" id="ZK353.10">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00044677"/>
    <dbReference type="CTD" id="4363052"/>
    <dbReference type="WormBase" id="ZK353.10a">
        <property type="protein sequence ID" value="CE39460"/>
        <property type="gene ID" value="WBGene00044677"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3191811_0_0_1"/>
    <dbReference type="OrthoDB" id="5863557at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044677">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2V4Y0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004217633" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD73209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZK353.10a"/>
        </source>
    </evidence>
    <sequence length="46" mass="5176" checksum="E11B1D78AD7F8033" modified="2006-01-10" version="1">MTLIALALVAFSLALGRKIDLMVEQKVEERMVIYSVHGIELTETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-06-15" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q7K866</accession>
    <name>Q7K866_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Trehalase</fullName>
            <ecNumber evidence="2 4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tre-2</name>
        <name evidence="5" type="synonym">tre2</name>
        <name evidence="6" type="ORF">CELE_T05A12.2</name>
        <name evidence="8" type="ORF">T05A12.2</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2003" name="Int. J. Parasitol." volume="33" first="1195" last="1206">
            <title>Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes.</title>
            <authorList>
                <person name="Pellerone F.I."/>
                <person name="Archer S.K."/>
                <person name="Behm C.A."/>
                <person name="Grant W.N."/>
                <person name="Lacey M.J."/>
                <person name="Somerville A.C."/>
            </authorList>
            <dbReference type="PubMed" id="13678635"/>
            <dbReference type="DOI" id="10.1016/S0020-7519(03)00173-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2 4"/>
    <dbReference type="EMBL" id="AJ512334">
        <property type="protein sequence ID" value="CAD54508.2"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T28884">
        <property type="entry name" value="T28884"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293773.1">
        <property type="nucleotide sequence ID" value="NM_001306844.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7K866"/>
    <dbReference type="SMR" id="Q7K866"/>
    <dbReference type="CAZy" id="GH37">
        <property type="family name" value="Glycoside Hydrolase Family 37"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q7K866"/>
    <dbReference type="GeneID" id="177451"/>
    <dbReference type="KEGG" id="cel:CELE_T05A12.2"/>
    <dbReference type="AGR" id="WB:WBGene00006608"/>
    <dbReference type="CTD" id="177451"/>
    <dbReference type="WormBase" id="T05A12.2b">
        <property type="protein sequence ID" value="CE04897"/>
        <property type="gene ID" value="WBGene00006608"/>
        <property type="gene designation" value="tre-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006451_4_1_1"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006608">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7K866">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF24">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD54508.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDK13500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="T05A12.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q7K866"/>
        </source>
    </evidence>
    <sequence length="585" mass="66485" checksum="A269BAA5817FF1CC" modified="2010-06-15" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N4I5</accession>
    <name>Q9N4I5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Increased recombination centers protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y71F9AL.12</name>
        <name evidence="2 4" type="ORF">Y71F9AL.12</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD73513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491060.3">
        <property type="nucleotide sequence ID" value="NM_058659.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N4I5"/>
    <dbReference type="STRING" id="6239.Y71F9AL.12.1"/>
    <dbReference type="PaxDb" id="6239-Y71F9AL.12"/>
    <dbReference type="PeptideAtlas" id="Q9N4I5"/>
    <dbReference type="GeneID" id="190588"/>
    <dbReference type="UCSC" id="Y71F9AL.12">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022117"/>
    <dbReference type="CTD" id="190588"/>
    <dbReference type="WormBase" id="Y71F9AL.12a">
        <property type="protein sequence ID" value="CE45872"/>
        <property type="gene ID" value="WBGene00022117"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TGXE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082221_0_0_1"/>
    <dbReference type="OMA" id="DLVCTKN"/>
    <dbReference type="OrthoDB" id="5862601at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022117">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N4I5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD73513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y71F9AL.12a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N4I5"/>
        </source>
    </evidence>
    <sequence length="289" mass="32224" checksum="0B5ED609BB51BC64" modified="2011-05-03" version="2">MSEKNEHFMVKCKGPPKQFLAIVGDTDGMIRKSLEERSKAVKEEADCYFIETYYYSAKYGIKTYETLSELSADYEANNAPIMCIFFALKSMDQLEEAKTVSNQVKADTKVIIVESLELCPDFDGLEKFVAENEFEVVFLKPNEDQLVEAAEQAEKIGVDRLIETMEVCNWPWRVVNAIGKGTLSNFMDDEADPTEYNMNEDDTISGPAADQLIRHFAQWIDQNPDATIPAPQHAERVNLSPDSPTTTEGTTNQDDVSISVDIDLVCATKNLGENGGSSGENEKKAEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEY4</accession>
    <name>U4PEY4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Deubiquitinating enzyme A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">otub-4</name>
        <name evidence="12" type="ORF">B0546.2</name>
        <name evidence="10" type="ORF">CELE_B0546.2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C85 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368281.1">
        <property type="nucleotide sequence ID" value="NM_001380141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEY4"/>
    <dbReference type="SMR" id="U4PEY4"/>
    <dbReference type="GeneID" id="177104"/>
    <dbReference type="KEGG" id="cel:CELE_B0546.2"/>
    <dbReference type="AGR" id="WB:WBGene00015249"/>
    <dbReference type="CTD" id="177104"/>
    <dbReference type="WormBase" id="B0546.2b">
        <property type="protein sequence ID" value="CE48773"/>
        <property type="gene ID" value="WBGene00015249"/>
        <property type="gene designation" value="otub-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054844_0_0_1"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015249">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEY4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22752">
        <property type="entry name" value="OTU_OTUD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000018">
        <property type="entry name" value="OTU domain-containing protein 5-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF4">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="9">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDH93299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="B0546.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="U4PEY4"/>
        </source>
    </evidence>
    <sequence length="323" mass="35777" checksum="C02FF1FBC47EA637" modified="2013-12-11" version="1">MQNIRDDEIETEFSNRLAARGLIIKEMVGDGACMFRSIAEQIYGDQEMHGQIRRLCMDYMSNNRDHFKEFITENFENYIQRKREENVHGNHVELQAISEMFARPVEVYQYSDEPINVLLPRPEPEATALTDGSASTSNAAPPPSTVPIQQNPPLRLSYHRAVHYNAILAPNIPTIGIGLGLPGMIPGSADKELMSTAMKTSELEHIEETMLQDKIDMTDFQRTQADIEDQITRESLISYLNDFEKSKNAPSTSAGAPGPSNFSGEPPVSGSGLYEEMLAAQSLEWDAYTDDVAIAEAMLVSQQDYMSNKPSTSSSGSGPSTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEZ3</accession>
    <name>U4PEZ3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C34H4.1</name>
        <name evidence="2" type="ORF">CELE_C34H4.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368284.1">
        <property type="nucleotide sequence ID" value="NM_001380049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEZ3"/>
    <dbReference type="PeptideAtlas" id="U4PEZ3"/>
    <dbReference type="GeneID" id="176963"/>
    <dbReference type="KEGG" id="cel:CELE_C34H4.1"/>
    <dbReference type="AGR" id="WB:WBGene00016424"/>
    <dbReference type="CTD" id="176963"/>
    <dbReference type="WormBase" id="C34H4.1b">
        <property type="protein sequence ID" value="CE48846"/>
        <property type="gene ID" value="WBGene00016424"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040349_1_0_1"/>
    <dbReference type="OrthoDB" id="5817365at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016424">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEZ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005071">
        <property type="entry name" value="Glycoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21733:SF5">
        <property type="entry name" value="AMINE OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21733">
        <property type="entry name" value="CUB_2 DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03409">
        <property type="entry name" value="Glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C34H4.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PEZ3"/>
        </source>
    </evidence>
    <sequence length="97" mass="10896" checksum="C87148989305AA9E" modified="2013-12-11" version="1">MNVTSCYNTDCITEKFVQTMPVYTDIFQYPKNYTTLYMDHTNTNEGIFYLQYCRSEAAVGVSSTTPASMETTTKTSATISLHILLIISLISMISILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEZ8</accession>
    <name>U4PEZ8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nhr-274</name>
        <name evidence="6" type="ORF">CELE_Y41D4B.21</name>
        <name evidence="8" type="ORF">Y41D4B.21</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368289.1">
        <property type="nucleotide sequence ID" value="NM_001380055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEZ8"/>
    <dbReference type="SMR" id="U4PEZ8"/>
    <dbReference type="GeneID" id="189825"/>
    <dbReference type="AGR" id="WB:WBGene00021522"/>
    <dbReference type="CTD" id="189825"/>
    <dbReference type="WormBase" id="Y41D4B.21b">
        <property type="protein sequence ID" value="CE49118"/>
        <property type="gene ID" value="WBGene00021522"/>
        <property type="gene designation" value="nhr-274"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5772425at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021522">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEZ8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587:SF3">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="39"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH93314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y41D4B.21b"/>
        </source>
    </evidence>
    <sequence length="317" mass="36325" checksum="02C3F27CFDC4A675" modified="2013-12-11" version="1">MKASAIQRRDVMGPRKPKIKESIVKTEIIEEVPKLIMSSNPSSTGSMSEGPPKHKRPLLEDLVEVQRWQCSKHHSFFEAHEAINLDGDLSSMTYLKLNGTLHRRARARDVNSMLKLGLIDAATWGNQFDLFRRLSTEEKKHILTEFGFTFMLVDQGYKTAQKAEKGFWLLQNDTYMHEDYFLGLPEEDARKENAATKAKLHPLFVNESLNCVGYPFKNLQIDEHECAVLKTILLLTQQGVFKHCVNEVKHLYDCCMTELMGHSQRKYPDTAAERFGTIILLTSSIRCAINALYNQTRVSDVFDLMKFDPLVRDVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4PF95</accession>
    <name>U4PF95_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Synembryn-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ric-8</name>
        <name evidence="6" type="ORF">CELE_Y69A2AR.2</name>
        <name evidence="8" type="ORF">Y69A2AR.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380145.1">
        <property type="nucleotide sequence ID" value="NM_001392268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PF95"/>
    <dbReference type="SMR" id="U4PF95"/>
    <dbReference type="PeptideAtlas" id="U4PF95"/>
    <dbReference type="GeneID" id="177048"/>
    <dbReference type="AGR" id="WB:WBGene00004367"/>
    <dbReference type="CTD" id="177048"/>
    <dbReference type="WormBase" id="Y69A2AR.2d">
        <property type="protein sequence ID" value="CE48786"/>
        <property type="gene ID" value="WBGene00004367"/>
        <property type="gene designation" value="ric-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018602_1_0_1"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004367">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PF95">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008376">
        <property type="entry name" value="Chaperone_Ric-8_A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01802">
        <property type="entry name" value="SYNEMBRYN"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH93411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y69A2AR.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="U4PF95"/>
        </source>
    </evidence>
    <sequence length="281" mass="31151" checksum="A42CD1CBA9300A08" modified="2013-12-11" version="1">MVLSVLCGKNSKNNGGENEEEKFFVEELSNMQLTEAILMHLDKQLTKVVALLLNDAPNQQQNPMLSAEASTLTDLVGPYFQVLARLCTDSKYVRRYCRIRVIPPLVSEEVQKRPEENNTLRGRIARIMMLPSSTKDVAAEFLFIICKRSVNRMIKYLGFGHSAGHLANLGLLGQINQPKHASDSEDSETEDYNQIKDSVNPVTGAIYPSDHGSALAGMSEEQKEYEAMKLVDAMNQMMETGIVKPGTIGDDGKIREVSHVLELLKNAPEPAPAENSDSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>W6RTC2</accession>
    <name>W6RTC2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">dapk-1</name>
        <name evidence="12" type="ORF">CELE_K12C11.4</name>
        <name evidence="14" type="ORF">K12C11.4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293415.1">
        <property type="nucleotide sequence ID" value="NM_001306486.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RTC2"/>
    <dbReference type="SMR" id="W6RTC2"/>
    <dbReference type="GeneID" id="187322"/>
    <dbReference type="AGR" id="WB:WBGene00003400"/>
    <dbReference type="CTD" id="187322"/>
    <dbReference type="WormBase" id="K12C11.4b">
        <property type="protein sequence ID" value="CE49530"/>
        <property type="gene ID" value="WBGene00003400"/>
        <property type="gene designation" value="dapk-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002849_2_0_1"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003400">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RTC2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08782">
        <property type="entry name" value="Death_DAPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="429"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Roc" evidence="11">
        <location>
            <begin position="534"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="10">
        <location>
            <begin position="1158"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM63492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="K12C11.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="W6RTC2"/>
        </source>
    </evidence>
    <sequence length="1264" mass="140819" checksum="86CB2922964BC0C3" modified="2014-04-16" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-02-22" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>X5LX76-2</accession>
    <name>FGDH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of FYVE, RhoGEF and PH domain-containing protein tag-77</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tag-77</name>
        <name evidence="4" type="ORF">C28C12.10</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Science" volume="377" first="eabo3191" last="eabo3191">
            <title>Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.</title>
            <authorList>
                <person name="Bou Sleiman M."/>
                <person name="Roy S."/>
                <person name="Gao A.W."/>
                <person name="Sadler M.C."/>
                <person name="von Alvensleben G.V.G."/>
                <person name="Li H."/>
                <person name="Sen S."/>
                <person name="Harrison D.E."/>
                <person name="Nelson J.F."/>
                <person name="Strong R."/>
                <person name="Miller R.A."/>
                <person name="Kutalik Z."/>
                <person name="Williams R.W."/>
                <person name="Auwerx J."/>
            </authorList>
            <dbReference type="PubMed" id="36173858"/>
            <dbReference type="DOI" id="10.1126/science.abo3191"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>X5LX76-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>X5LX76-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061766"/>
        </isoform>
        <isoform>
            <id>X5LX76-6</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_061766 VSP_061764"/>
        </isoform>
        <isoform>
            <id>X5LX76-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_061764"/>
        </isoform>
        <isoform>
            <id>X5LX76-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_061765 VSP_061766"/>
        </isoform>
        <isoform>
            <id>X5LX76-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_061765"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_501455.2">
        <property type="nucleotide sequence ID" value="NM_069054.6"/>
    </dbReference>
    <dbReference type="WormBase" id="C28C12.10a">
        <property type="protein sequence ID" value="CE53883"/>
        <property type="gene ID" value="WBGene00006450"/>
        <property type="gene designation" value="tag-77"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C28C12.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C28C12.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C28C12.10c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C28C12.10d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C28C12.10e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C28C12.10f"/>
        </source>
    </evidence>
    <sequence length="1027" mass="118084" checksum="73B63F50EA060461" modified="2020-04-22" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-02-22" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>X5LX76-3</accession>
    <name>FGDH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of FYVE, RhoGEF and PH domain-containing protein tag-77</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tag-77</name>
        <name evidence="4" type="ORF">C28C12.10</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
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                <person name="Sen S."/>
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                <person name="Nelson J.F."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Science" volume="377" first="eabo3191" last="eabo3191">
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                <person name="Gao A.W."/>
                <person name="Sadler M.C."/>
                <person name="von Alvensleben G.V.G."/>
                <person name="Li H."/>
                <person name="Sen S."/>
                <person name="Harrison D.E."/>
                <person name="Nelson J.F."/>
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                <person name="Gao A.W."/>
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                <person name="von Alvensleben G.V.G."/>
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                <person name="Gao A.W."/>
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    <reference evidence="4" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
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            <dbReference type="PubMed" id="17596296"/>
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            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
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                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
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            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
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        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
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                <person name="Lee E.C."/>
                <person name="Strange K."/>
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            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
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                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
            </authorList>
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            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
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        <scope>ACTIVITY REGULATION</scope>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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    <reference evidence="2" key="2">
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            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
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                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
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            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
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            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
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                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
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    <evidence type="ECO:0000305" key="3">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="C46C2.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="C46C2.1n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="22">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="23">
        <source>
            <dbReference type="WormBase" id="C46C2.1s"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="24">
        <source>
            <dbReference type="WormBase" id="C46C2.1t"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="25">
        <source>
            <dbReference type="WormBase" id="C46C2.1u"/>
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    </evidence>
    <evidence type="ECO:0000312" key="26">
        <source>
            <dbReference type="WormBase" id="C46C2.1v"/>
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    </evidence>
    <sequence length="1677" mass="181786" checksum="1BA72D2D756C7958" modified="2014-06-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
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        <name evidence="18" type="primary">wnk-1</name>
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    <organism>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Choe K.P."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="70" last="75">
            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="18049475"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
            <authorList>
                <person name="Lee E.C."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
            <authorList>
                <person name="Boyd-Shiwarski C.R."/>
                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
            </authorList>
            <dbReference type="PubMed" id="36318922"/>
            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
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        <isoform>
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    </evidence>
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    </evidence>
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    <evidence type="ECO:0000312" key="26">
        <source>
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</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
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    <organism>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Choe K.P."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="70" last="75">
            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
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            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
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                <person name="Lee E.C."/>
                <person name="Strange K."/>
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            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
            <authorList>
                <person name="Boyd-Shiwarski C.R."/>
                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
            </authorList>
            <dbReference type="PubMed" id="36318922"/>
            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
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        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <strain evidence="4">Bristol N2</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
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            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
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                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
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            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
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        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
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    <reference evidence="2" key="4">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
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            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
            <authorList>
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                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
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            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
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        <scope>ACTIVITY REGULATION</scope>
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            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
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                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
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            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
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        <scope>ACTIVITY REGULATION</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
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            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
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            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
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                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
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    <reference evidence="2" key="4">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
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                <person name="Strange K."/>
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            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
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        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
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                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
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            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
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        <scope>FUNCTION</scope>
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            <id>X5M5N0-20</id>
            <name evidence="24">t</name>
            <sequence type="described" ref="VSP_057685 VSP_057687 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-13</id>
            <name evidence="16">l</name>
            <sequence type="described" ref="VSP_057688 VSP_057684"/>
        </isoform>
        <isoform>
            <id>X5M5N0-1</id>
            <name evidence="18">n</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>X5M5N0-19</id>
            <name evidence="23">s</name>
            <sequence type="described" ref="VSP_057687 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-5</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_057686 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-4</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_057688 VSP_057685 VSP_057684 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-17</id>
            <name evidence="21">q</name>
            <sequence type="described" ref="VSP_057687 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-14</id>
            <name evidence="17">m</name>
            <sequence type="described" ref="VSP_057686 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_057686 VSP_057688 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-7</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_057688 VSP_057686 VSP_057684"/>
        </isoform>
        <isoform>
            <id>X5M5N0-9</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_057688 VSP_057687 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-16</id>
            <name evidence="20">p</name>
            <sequence type="described" ref="VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-22</id>
            <name evidence="26">v</name>
            <sequence type="described" ref="VSP_057683"/>
        </isoform>
        <isoform>
            <id>X5M5N0-11</id>
            <name evidence="14">j</name>
            <sequence type="described" ref="VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-8</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_057688 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-6</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_057686 VSP_057688 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-18</id>
            <name evidence="22">r</name>
            <sequence type="described" ref="VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-3</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_057688 VSP_057687 VSP_057685 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-15</id>
            <name evidence="19">o</name>
            <sequence type="described" ref="VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-10</id>
            <name evidence="13">i</name>
            <sequence type="described" ref="VSP_057688 VSP_057685 VSP_057684"/>
        </isoform>
        <isoform>
            <id>X5M5N0-12</id>
            <name evidence="15">k</name>
            <sequence type="described" ref="VSP_057688 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-21</id>
            <name evidence="25">u</name>
            <sequence type="described" ref="VSP_057683 VSP_057688"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001255372.1">
        <property type="nucleotide sequence ID" value="NM_001268443.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C46C2.1g">
        <property type="protein sequence ID" value="CE46722"/>
        <property type="gene ID" value="WBGene00006941"/>
        <property type="gene designation" value="wnk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="17596296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C46C2.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C46C2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C46C2.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C46C2.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="C46C2.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="C46C2.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="C46C2.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="C46C2.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="C46C2.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="C46C2.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="C46C2.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="C46C2.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="C46C2.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="C46C2.1n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="C46C2.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
            <dbReference type="WormBase" id="C46C2.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
            <dbReference type="WormBase" id="C46C2.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="22">
        <source>
            <dbReference type="WormBase" id="C46C2.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="23">
        <source>
            <dbReference type="WormBase" id="C46C2.1s"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="24">
        <source>
            <dbReference type="WormBase" id="C46C2.1t"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="25">
        <source>
            <dbReference type="WormBase" id="C46C2.1u"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="26">
        <source>
            <dbReference type="WormBase" id="C46C2.1v"/>
        </source>
    </evidence>
    <sequence length="1841" mass="198759" checksum="CE442AFAA04EC3CD" modified="2014-06-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>X5M5N0-9</accession>
    <name>WNK_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform h of Serine/threonine-protein kinase WNK</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein kinase with no lysine 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">wnk-1</name>
        <name evidence="18" type="ORF">C46C2.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Choe K.P."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="70" last="75">
            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="18049475"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>MUTAGENESIS OF LYS-346; SER-497; PHE-1133 AND PHE-1222</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
            <authorList>
                <person name="Lee E.C."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2022" name="Cell" volume="185" first="4488" last="4506">
            <title>WNK kinases sense molecular crowding and rescue cell volume via phase separation.</title>
            <authorList>
                <person name="Boyd-Shiwarski C.R."/>
                <person name="Shiwarski D.J."/>
                <person name="Griffiths S.E."/>
                <person name="Beacham R.T."/>
                <person name="Norrell L."/>
                <person name="Morrison D.E."/>
                <person name="Wang J."/>
                <person name="Mann J."/>
                <person name="Tennant W."/>
                <person name="Anderson E.N."/>
                <person name="Franks J."/>
                <person name="Calderon M."/>
                <person name="Connolly K.A."/>
                <person name="Cheema M.U."/>
                <person name="Weaver C.J."/>
                <person name="Nkashama L.J."/>
                <person name="Weckerly C.C."/>
                <person name="Querry K.E."/>
                <person name="Pandey U.B."/>
                <person name="Donnelly C.J."/>
                <person name="Sun D."/>
                <person name="Rodan A.R."/>
                <person name="Subramanya A.R."/>
            </authorList>
            <dbReference type="PubMed" id="36318922"/>
            <dbReference type="DOI" id="10.1016/j.cell.2022.09.042"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>X5M5N0-10</id>
            <name evidence="13">i</name>
            <sequence type="described" ref="VSP_057685 VSP_057684 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-9</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_057685 VSP_057687 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-17</id>
            <name evidence="21">q</name>
            <sequence type="described" ref="VSP_057687 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-5</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_057688 VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-14</id>
            <name evidence="17">m</name>
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        </isoform>
        <isoform>
            <id>X5M5N0-8</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_057685 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-1</id>
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            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>X5M5N0-7</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_057684 VSP_057686 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-6</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_057686 VSP_057688 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-16</id>
            <name evidence="20">p</name>
            <sequence type="described" ref="VSP_057686"/>
        </isoform>
        <isoform>
            <id>X5M5N0-22</id>
            <name evidence="26">v</name>
            <sequence type="described" ref="VSP_057683"/>
        </isoform>
        <isoform>
            <id>X5M5N0-18</id>
            <name evidence="22">r</name>
            <sequence type="described" ref="VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-2</id>
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            <sequence type="described" ref="VSP_057685 VSP_057686 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-20</id>
            <name evidence="24">t</name>
            <sequence type="described" ref="VSP_057687 VSP_057686 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-21</id>
            <name evidence="25">u</name>
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        </isoform>
        <isoform>
            <id>X5M5N0-3</id>
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            <sequence type="described" ref="VSP_057687 VSP_057686 VSP_057688 VSP_057685"/>
        </isoform>
        <isoform>
            <id>X5M5N0-15</id>
            <name evidence="19">o</name>
            <sequence type="described" ref="VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-11</id>
            <name evidence="14">j</name>
            <sequence type="described" ref="VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-19</id>
            <name evidence="23">s</name>
            <sequence type="described" ref="VSP_057685 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-4</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_057686 VSP_057685 VSP_057684 VSP_057688"/>
        </isoform>
        <isoform>
            <id>X5M5N0-12</id>
            <name evidence="15">k</name>
            <sequence type="described" ref="VSP_057688 VSP_057687"/>
        </isoform>
        <isoform>
            <id>X5M5N0-13</id>
            <name evidence="16">l</name>
            <sequence type="described" ref="VSP_057688 VSP_057684"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001255373.1">
        <property type="nucleotide sequence ID" value="NM_001268444.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C46C2.1h">
        <property type="protein sequence ID" value="CE46797"/>
        <property type="gene ID" value="WBGene00006941"/>
        <property type="gene designation" value="wnk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="17596296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C46C2.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C46C2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C46C2.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C46C2.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="C46C2.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="C46C2.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="C46C2.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="C46C2.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="C46C2.1i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="C46C2.1j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="C46C2.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="C46C2.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="C46C2.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="C46C2.1n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="C46C2.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
            <dbReference type="WormBase" id="C46C2.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
            <dbReference type="WormBase" id="C46C2.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="22">
        <source>
            <dbReference type="WormBase" id="C46C2.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="23">
        <source>
            <dbReference type="WormBase" id="C46C2.1s"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="24">
        <source>
            <dbReference type="WormBase" id="C46C2.1t"/>
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    <evidence type="ECO:0000312" key="25">
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            <dbReference type="WormBase" id="C46C2.1u"/>
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        <source>
            <dbReference type="WormBase" id="C46C2.1v"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">Bristol N2</strain>
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    </reference>
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    <dbReference type="Bgee" id="WBGene00004123">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="C44H9.5b"/>
        </source>
    </evidence>
    <sequence length="549" mass="62058" checksum="258B0AF0E36FB583" modified="2018-12-05" version="1"> </sequence>
</entry>
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    <accession>A0A3B1E3U1</accession>
    <name>A0A3B1E3U1_CAEEL</name>
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        <name evidence="4" type="ORF">CELE_W09D12.1</name>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="WBGene00012364"/>
        <property type="gene designation" value="zmp-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012364">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1E3U1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000028">
        <property type="entry name" value="Serpentine receptor class gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
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    </dbReference>
    <dbReference type="SMART" id="SM00120">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017334127" evidence="3">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VAY52534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="W09D12.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A3B1E3U1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27516" checksum="664D8032B805E82F" modified="2018-12-05" version="1">MNFNLSSVLLIFSYVLCAIAGPPGIEVDTDTAEDNSVGNEGLSSVDHSTPSSDVDRSKCPKHLDSVVAINDQEWLFFRSNKVYKLNNRKFVDSGRPIQQVFPRGPQFVNATVSSGPLTLLFVERTIYGYEYDGVQFTEAPNYPKELHDRVLFYPQGAFPLNNGSVILLSGNVFATYNVQQNAPSFLNDKNRYFPNLPEDIKSGIEKTQGFTDAYYMFDEATVSDYDMNSKQVLQLQNIPDFLKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1E3V6</accession>
    <name>A0A3B1E3V6_CAEEL</name>
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        </submittedName>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
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    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001368505.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1E3V6"/>
    <dbReference type="SMR" id="A0A3B1E3V6"/>
    <dbReference type="GeneID" id="180826"/>
    <dbReference type="AGR" id="WB:WBGene00003166"/>
    <dbReference type="CTD" id="180826"/>
    <dbReference type="WormBase" id="F14D12.4h">
        <property type="protein sequence ID" value="CE52756"/>
        <property type="gene ID" value="WBGene00003166"/>
        <property type="gene designation" value="mec-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003166">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1E3V6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03403">
        <property type="entry name" value="SPFH_stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
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        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="80"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="422"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VAY52584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F14D12.4h"/>
        </source>
    </evidence>
    <sequence length="422" mass="45913" checksum="933372F5A7007D19" modified="2018-12-05" version="1">MSRKRSIRERMAEMADSRRNPKKPTPPSIFEAAQLIGKFSGQRIDLLSANIQNEFGVCGWILTILSYLLIFFTLPISACMCIKVVQEYERAVIFRLGRLMPGGAKGPGIFFIVPCIDTYRKVDLRVLSFEVPPQEILSKDSVTVAVDAVVYFRISNATISVTNVEDAARSTKLLAQTTLRNILGTKTLAEMLSDREAISHQMQTTLDEATEPWGVKVERVEVKDVRLPVQLQRAMAAEAEAAREARAKVIVAEGEQKASRALKEAAEVIAESPSALQLRYLQTLNSISAEKNSTIIFPFPIDLLSAFLQRTPPKVEEPPSLPKKIRSCCLYKYPDWVQGMVGSEGGGGHGHSHGGGGGGLGSSQGAFHPSQAGSGPSTTTTSGRPLLRSMREAQFHSAAPPISAPNQSQTSVSQLDPALLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-06-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A486WTC7</accession>
    <name>A0A486WTC7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="ORF">C13B4.1</name>
        <name evidence="11" type="ORF">CELE_C13B4.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="VGM69477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360458.1">
        <property type="nucleotide sequence ID" value="NM_001373819.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A486WTC7"/>
    <dbReference type="GeneID" id="175104"/>
    <dbReference type="AGR" id="WB:WBGene00007545"/>
    <dbReference type="CTD" id="175104"/>
    <dbReference type="WormBase" id="C13B4.1e">
        <property type="protein sequence ID" value="CE53102"/>
        <property type="gene ID" value="WBGene00007545"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813822at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A486WTC7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900449">
        <property type="term" value="P:regulation of glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09628">
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR042789">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902:SF1">
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    </dbReference>
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    </dbReference>
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</entry>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
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            <begin position="1"/>
            <end position="12"/>
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        </location>
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            <begin position="575"/>
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        <location>
            <begin position="606"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50042"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG4685893.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="C30D11.1o"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A8D7ZGB1"/>
        </source>
    </evidence>
    <sequence length="724" mass="80869" checksum="8D86EFF33AB2EFFB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-10-23" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>A7WK39</accession>
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            <taxon>Rhabditina</taxon>
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            <taxon>Rhabditidae</taxon>
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        </lineage>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <strain evidence="8 9">Bristol N2</strain>
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        <text evidence="4">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
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        <text evidence="1">Belongs to the isochorismatase family.</text>
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        <property type="project" value="WormBase"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006769">
        <property type="term" value="P:nicotinamide metabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.850:FF:000013">
        <property type="entry name" value="Pyrazinamidase and NiCotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF33">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="7">
        <location>
            <begin position="74"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD70256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y38C1AA.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A7WK39"/>
        </source>
    </evidence>
    <sequence length="315" mass="35428" checksum="E1DC17F775D63338" modified="2007-10-23" version="1">MVHSDNSATTNNNTILGNQSLEAIPEQLSELTGITVEESERIMESWLGNRQLDLRTSVLFDQEVLSRLRSLRVALLVVDFQNDFVDGSLKIGDGDAGQEPSSAITPLNELLQLSSWDLVVYTKDWHPHNHISFLSQAHNSDRVMDEKDENKTLGFFDSVQFLKPIKTEQVLYPDHCIQKSWGSDIHPEIYIADNAEYIMKGVDPYLDSYSAFNDNNGRSKTELEDLLRRENIDAVVIAGLAYDICVRFTCLDAVKQNFLAAVIPECSAGLTKKGIEESEMAFKKQGVAMISKDEARGITEGGFLPREWVQRIVKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-12-20" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>B6VQ60-2</accession>
    <name>BRCA1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Breast cancer type 1 susceptibility protein homolog</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RING-type E3 ubiquitin transferase BRCA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">brc-1</name>
        <name evidence="6" type="ORF">C36A4.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2004" name="Curr. Biol." volume="14" first="33" last="39">
            <title>BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Boulton S.J."/>
                <person name="Martin J.S."/>
                <person name="Polanowska J."/>
                <person name="Hill D.E."/>
                <person name="Gartner A."/>
                <person name="Vidal M."/>
            </authorList>
            <dbReference type="PubMed" id="14711411"/>
            <dbReference type="DOI" id="10.1016/j.cub.2003.11.029"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH BRD-1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2006" name="EMBO J." volume="25" first="2178" last="2188">
            <title>A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.</title>
            <authorList>
                <person name="Polanowska J."/>
                <person name="Martin J.S."/>
                <person name="Garcia-Muse T."/>
                <person name="Petalcorin M.I.R."/>
                <person name="Boulton S.J."/>
            </authorList>
            <dbReference type="PubMed" id="16628214"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7601102"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>PATHWAY</scope>
        <scope>UBIQUITINATION</scope>
        <scope>IDENTIFICATION IN CEBCD COMPLEX WITH BRD-1; RAD-51 AND LET-70</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>PHOSPHORYLATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="287" last="292">
            <title>BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair.</title>
            <authorList>
                <person name="Adamo A."/>
                <person name="Montemauri P."/>
                <person name="Silva N."/>
                <person name="Ward J.D."/>
                <person name="Boulton S.J."/>
                <person name="La Volpe A."/>
            </authorList>
            <dbReference type="PubMed" id="18219312"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7401167"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2009" name="Curr. Biol." volume="19" first="1384" last="1388">
            <title>A robust network of double-strand break repair pathways governs genome integrity during C. elegans development.</title>
            <authorList>
                <person name="Pontier D.B."/>
                <person name="Tijsterman M."/>
            </authorList>
            <dbReference type="PubMed" id="19646877"/>
            <dbReference type="DOI" id="10.1016/j.cub.2009.06.045"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="6">
        <citation type="journal article" date="2010" name="J. Biol. Chem." volume="285" first="13437" last="13443">
            <title>Developmental arrest of Caenorhabditis elegans BRAP-2 mutant exposed to oxidative stress is dependent on BRC-1.</title>
            <authorList>
                <person name="Koon J.C."/>
                <person name="Kubiseski T.J."/>
            </authorList>
            <dbReference type="PubMed" id="20207739"/>
            <dbReference type="DOI" id="10.1074/jbc.M110.107011"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="4" key="7">
        <citation type="journal article" date="2014" name="Genetics" volume="196" first="985" last="999">
            <title>Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants.</title>
            <authorList>
                <person name="Wolters S."/>
                <person name="Ermolaeva M.A."/>
                <person name="Bickel J.S."/>
                <person name="Fingerhut J.M."/>
                <person name="Khanikar J."/>
                <person name="Chan R.C."/>
                <person name="Schumacher B."/>
            </authorList>
            <dbReference type="PubMed" id="24424777"/>
            <dbReference type="DOI" id="10.1534/genetics.113.158295"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="8">
        <citation type="journal article" date="2016" name="Mol. Cells" volume="39" first="204" last="210">
            <title>DNA strand breaks in mitotic germ cells of Caenorhabditis elegans evaluated by comet assay.</title>
            <authorList>
                <person name="Park S."/>
                <person name="Choi S."/>
                <person name="Ahn B."/>
            </authorList>
            <dbReference type="PubMed" id="26903030"/>
            <dbReference type="DOI" id="10.14348/molcells.2016.2206"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2018" name="PLoS Genet." volume="14" first="e1007653" last="e1007653">
            <title>BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis.</title>
            <authorList>
                <person name="Janisiw E."/>
                <person name="Dello Stritto M.R."/>
                <person name="Jantsch V."/>
                <person name="Silva N."/>
            </authorList>
            <dbReference type="PubMed" id="30383754"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1007653"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MSH-5 AND SYP-3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>B6VQ60-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_059259"/>
        </isoform>
        <isoform>
            <id>B6VQ60-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="RefSeq" id="NP_001254882.1">
        <property type="nucleotide sequence ID" value="NM_001267953.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C36A4.8b">
        <property type="protein sequence ID" value="CE43228"/>
        <property type="gene ID" value="WBGene00000264"/>
        <property type="gene designation" value="brc-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16628214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="14711411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C36A4.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C36A4.8b"/>
        </source>
    </evidence>
    <sequence length="117" mass="13737" checksum="A18F6013E5DB7F3E" modified="2008-12-16" version="1">MGWLRSRNDEHGKLFAGRRFMILRKFTMNPYFDYKQLIELVQQCGGEILSCYENLSPEKLYIIFSKHSKAIEESKNIENLYKCDVVTMEWVLDSISEYLILPTQPYKAVDSIGCLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>F8WU09</accession>
    <name>F8WU09_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ttc-7</name>
        <name evidence="4" type="ORF">CELE_Y39A3CR.3</name>
        <name evidence="6" type="ORF">Y39A3CR.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD62162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254846.1">
        <property type="nucleotide sequence ID" value="NM_001267917.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F8WU09"/>
    <dbReference type="SMR" id="F8WU09"/>
    <dbReference type="PeptideAtlas" id="F8WU09"/>
    <dbReference type="GeneID" id="175332"/>
    <dbReference type="AGR" id="WB:WBGene00021444"/>
    <dbReference type="CTD" id="175332"/>
    <dbReference type="WormBase" id="Y39A3CR.3b">
        <property type="protein sequence ID" value="CE46425"/>
        <property type="gene ID" value="WBGene00021444"/>
        <property type="gene designation" value="ttc-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010512_0_0_1"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021444">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F8WU09">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001885">
        <property type="entry name" value="TeTratriCopeptide repeat domain protein related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD62162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y39A3CR.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="F8WU09"/>
        </source>
    </evidence>
    <sequence length="575" mass="62759" checksum="62155C878A702A9A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>F8WU11</accession>
    <name>F8WU11_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y51H7BR.4</name>
        <name evidence="2 4" type="ORF">Y51H7BR.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD72684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254030.1">
        <property type="nucleotide sequence ID" value="NM_001267101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F8WU11"/>
    <dbReference type="SMR" id="F8WU11"/>
    <dbReference type="GeneID" id="190169"/>
    <dbReference type="AGR" id="WB:WBGene00021776"/>
    <dbReference type="CTD" id="190169"/>
    <dbReference type="WormBase" id="Y51H7BR.4b">
        <property type="protein sequence ID" value="CE46351"/>
        <property type="gene ID" value="WBGene00021776"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1836886_0_0_1"/>
    <dbReference type="OrthoDB" id="5841292at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021776">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F8WU11">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD72684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y51H7BR.4b"/>
        </source>
    </evidence>
    <sequence length="140" mass="16189" checksum="392E2115DEF3FAEA" modified="2011-10-19" version="1">MVSMRTLTWTFILMQLVFSCACFIASLAIISAKFNSVSVYEDKQYISFEWWIFCGLSFSMIINTVAAMYALAEHNRFLLIPHIFLLILCNSLACYVLHYTISNFDSTDFNWHIGLMTIICTESFLLSCLVFEVRTLRSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>G4SKK4</accession>
    <name>G4SKK4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc transporter ZIP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">zipt-2.4</name>
        <name evidence="7" type="ORF">CELE_F55F8.9</name>
        <name evidence="9" type="ORF">F55F8.9</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD71891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001249971.1">
        <property type="nucleotide sequence ID" value="NM_001263042.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4SKK4"/>
    <dbReference type="SMR" id="G4SKK4"/>
    <dbReference type="PeptideAtlas" id="G4SKK4"/>
    <dbReference type="GeneID" id="172230"/>
    <dbReference type="KEGG" id="cel:CELE_F55F8.9"/>
    <dbReference type="AGR" id="WB:WBGene00018897"/>
    <dbReference type="CTD" id="172230"/>
    <dbReference type="WormBase" id="F55F8.9b">
        <property type="protein sequence ID" value="CE44985"/>
        <property type="gene ID" value="WBGene00018897"/>
        <property type="gene designation" value="zipt-2.4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040462_1_1_1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018897">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G4SKK4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF219">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD71891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F55F8.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="G4SKK4"/>
        </source>
    </evidence>
    <sequence length="432" mass="47359" checksum="519F7E83B8D514DE" modified="2011-12-14" version="1">MNEAILKLVLMFVMFSLTVIVGLSPLKVLHKLRHEAATAQSSSKHKHVSLVLCLLTCFSGGVFLATCFLHLFPELRENLETLDTVHNFRIDYPVGELLSCLGFFLIFFLEEVVIMIIPSFAHGHGHGHGHDHHHHETTPPLASKSVEASGAGGCCMADTVDEIKKKEDDLVVDETTALTKTTKRAISEEKEGDGHCQTHCPLTVHERRGSNECTANATHTFAPVAFAEPERCETNCEAIDEDPPILMKSRPHAHSHGVRSITFVLALGIHSIIEGLAFGVQSGNDTIIALFLSLMVHKLIVAFSVGLQLFRTHAHQIKWVIISIFTLASMTPLGALIGLAVTSAADNALWKDLTITILQGLAVGTFIYVTFFEVLLHERDNEHPNLLKLLVMFIGFALIGALRGFESSHGHSHSGSTEPHFHGNSSFDDYGH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-02-06" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>G5EBF1-2</accession>
    <name>SAX3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Protein sax-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Sensory axon guidance 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sax-3</name>
        <name evidence="2" type="ORF">ZK377.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Cell" volume="92" first="217" last="227">
            <title>The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans.</title>
            <authorList>
                <person name="Zallen J.A."/>
                <person name="Yi B.A."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="9458046"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(00)80916-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Dev. Biol." volume="226" first="137" last="151">
            <title>Mechanisms controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites.</title>
            <authorList>
                <person name="Branda C.S."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="10993679"/>
            <dbReference type="DOI" id="10.1006/dbio.2000.9853"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="Elife" volume="6" first="0" last="0">
            <title>Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans.</title>
            <authorList>
                <person name="Kim B."/>
                <person name="Emmons S.W."/>
            </authorList>
            <dbReference type="PubMed" id="28901288"/>
            <dbReference type="DOI" id="10.7554/elife.29257"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EBF1-2</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_060409"/>
        </isoform>
        <isoform>
            <id>G5EBF1-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741748.2">
        <property type="nucleotide sequence ID" value="NM_171652.8"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK377.2a">
        <property type="protein sequence ID" value="CE25688"/>
        <property type="gene ID" value="WBGene00004729"/>
        <property type="gene designation" value="sax-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="ZK377.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="ZK377.2b"/>
        </source>
    </evidence>
    <sequence length="1269" mass="138925" checksum="BA3AE63B04662EB3" modified="2011-12-14" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-04-29" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>G5ECU7-2</accession>
    <name>JUN_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isoform b of Transcription factor jun-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Transcription factor AP-1 subunit jun-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">jun-1</name>
        <name evidence="6" type="ORF">T24H10.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Development" volume="134" first="3999" last="4009">
            <title>Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development.</title>
            <authorList>
                <person name="Oommen K.S."/>
                <person name="Newman A.P."/>
            </authorList>
            <dbReference type="PubMed" id="17942488"/>
            <dbReference type="DOI" id="10.1242/dev.002741"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PROBABLE INTERACTION WITH FOS-1</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="3888" last="3895">
            <title>Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation.</title>
            <authorList>
                <person name="Hiatt S.M."/>
                <person name="Duren H.M."/>
                <person name="Shyu Y.J."/>
                <person name="Ellis R.E."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
                <person name="Kariya K."/>
                <person name="Kerppola T.K."/>
                <person name="Hu C.D."/>
            </authorList>
            <dbReference type="PubMed" id="19570917"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-08-0833"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D; E AND F)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2014" name="Genesis" volume="52" first="29" last="38">
            <title>C. elegans nuclear receptor NHR-6 functionally interacts with the jun-1 transcription factor during spermatheca development.</title>
            <authorList>
                <person name="Gissendanner C.R."/>
                <person name="Cardin D."/>
                <person name="Dubose C.J."/>
                <person name="El Sayed M."/>
                <person name="Harmson J.S."/>
                <person name="Praslicka B."/>
                <person name="Rowan B.G."/>
            </authorList>
            <dbReference type="PubMed" id="24178943"/>
            <dbReference type="DOI" id="10.1002/dvg.22723"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5ECU7-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_057615"/>
        </isoform>
        <isoform>
            <id>G5ECU7-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_057619"/>
        </isoform>
        <isoform>
            <id>G5ECU7-6</id>
            <name evidence="1">f</name>
            <sequence type="described" ref="VSP_057617"/>
        </isoform>
        <isoform>
            <id>G5ECU7-1</id>
            <name evidence="6">a</name>
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        </isoform>
        <isoform>
            <id>G5ECU7-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_057618"/>
        </isoform>
        <isoform>
            <id>G5ECU7-5</id>
            <name evidence="10">e</name>
            <sequence type="described" ref="VSP_057616"/>
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    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAI46586" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="19570917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="ACB41727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAB76416.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T24H10.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T24H10.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T24H10.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T24H10.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T24H10.7e"/>
        </source>
    </evidence>
    <sequence length="300" mass="32760" checksum="A1685D036393C998" modified="2011-12-14" version="1">MMNNSFDMNVTQHTNSSPYRRQDMEVDDGEKESTAQYCKGFYDALRVMQTTNKYEFTGGAVSSPVLPVLQTAAFSPITPASASDMHTIVMSLLGNTPITSGPSIAPLSSPTLLPLVTSGDLDDLSMKILASSAIPGPPIISSSNSPDSSTTAVTTSQITAFQPLLNNFVSSTTASTSRPDKLNLTPPQQSAEIYAFNGVNSDDSDGGLDSRSASRCGMALDDQEKKKLERKRARNRQAATKCRQKKMDRIKELEEQVLHEKHRGQRLDAELLELNRALEHFRRTVEHHSGNGCPNNSIRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-04-29" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>G5ECU7-3</accession>
    <name>JUN_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isoform c of Transcription factor jun-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Transcription factor AP-1 subunit jun-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">jun-1</name>
        <name evidence="6" type="ORF">T24H10.7</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Development" volume="134" first="3999" last="4009">
            <title>Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development.</title>
            <authorList>
                <person name="Oommen K.S."/>
                <person name="Newman A.P."/>
            </authorList>
            <dbReference type="PubMed" id="17942488"/>
            <dbReference type="DOI" id="10.1242/dev.002741"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PROBABLE INTERACTION WITH FOS-1</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="3888" last="3895">
            <title>Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation.</title>
            <authorList>
                <person name="Hiatt S.M."/>
                <person name="Duren H.M."/>
                <person name="Shyu Y.J."/>
                <person name="Ellis R.E."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
                <person name="Kariya K."/>
                <person name="Kerppola T.K."/>
                <person name="Hu C.D."/>
            </authorList>
            <dbReference type="PubMed" id="19570917"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-08-0833"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D; E AND F)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2014" name="Genesis" volume="52" first="29" last="38">
            <title>C. elegans nuclear receptor NHR-6 functionally interacts with the jun-1 transcription factor during spermatheca development.</title>
            <authorList>
                <person name="Gissendanner C.R."/>
                <person name="Cardin D."/>
                <person name="Dubose C.J."/>
                <person name="El Sayed M."/>
                <person name="Harmson J.S."/>
                <person name="Praslicka B."/>
                <person name="Rowan B.G."/>
            </authorList>
            <dbReference type="PubMed" id="24178943"/>
            <dbReference type="DOI" id="10.1002/dvg.22723"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5ECU7-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_057619"/>
        </isoform>
        <isoform>
            <id>G5ECU7-6</id>
            <name evidence="1">f</name>
            <sequence type="described" ref="VSP_057617"/>
        </isoform>
        <isoform>
            <id>G5ECU7-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_057618"/>
        </isoform>
        <isoform>
            <id>G5ECU7-5</id>
            <name evidence="10">e</name>
            <sequence type="described" ref="VSP_057616"/>
        </isoform>
        <isoform>
            <id>G5ECU7-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5ECU7-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_057615"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001343787.1">
        <property type="nucleotide sequence ID" value="NM_001356879.3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="19570917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="ACB41727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAB76416.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T24H10.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T24H10.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T24H10.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T24H10.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T24H10.7e"/>
        </source>
    </evidence>
    <sequence length="253" mass="27267" checksum="2E5161DA111955C3" modified="2011-12-14" version="1">MQTTNKYEFTGGAVSSPVLPVLQTAAFSPITPASASDMHTIVMSLLGNTPITSGPSIAPLSSPTLLPLVTSGDLDDLSMKILASSAIPGPPIISSSNSPDSSTTAVTTSQITAFQPLLNNFVSSTTASTSRPDKLNLTPPQQSAEIYAFNGVNSDDSDGGLDSRSASRCGMALDDQEKKKLERKRARNRQAATKCRQKKMDRIKELEEQVLHEKHRGQRLDAELLELNRALEHFRRTVEHHSGNGCPNNSIRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-04-29" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>G5ECU7-4</accession>
    <name>JUN_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isoform d of Transcription factor jun-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Transcription factor AP-1 subunit jun-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">jun-1</name>
        <name evidence="6" type="ORF">T24H10.7</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Development" volume="134" first="3999" last="4009">
            <title>Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development.</title>
            <authorList>
                <person name="Oommen K.S."/>
                <person name="Newman A.P."/>
            </authorList>
            <dbReference type="PubMed" id="17942488"/>
            <dbReference type="DOI" id="10.1242/dev.002741"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PROBABLE INTERACTION WITH FOS-1</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="3888" last="3895">
            <title>Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation.</title>
            <authorList>
                <person name="Hiatt S.M."/>
                <person name="Duren H.M."/>
                <person name="Shyu Y.J."/>
                <person name="Ellis R.E."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
                <person name="Kariya K."/>
                <person name="Kerppola T.K."/>
                <person name="Hu C.D."/>
            </authorList>
            <dbReference type="PubMed" id="19570917"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-08-0833"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D; E AND F)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2014" name="Genesis" volume="52" first="29" last="38">
            <title>C. elegans nuclear receptor NHR-6 functionally interacts with the jun-1 transcription factor during spermatheca development.</title>
            <authorList>
                <person name="Gissendanner C.R."/>
                <person name="Cardin D."/>
                <person name="Dubose C.J."/>
                <person name="El Sayed M."/>
                <person name="Harmson J.S."/>
                <person name="Praslicka B."/>
                <person name="Rowan B.G."/>
            </authorList>
            <dbReference type="PubMed" id="24178943"/>
            <dbReference type="DOI" id="10.1002/dvg.22723"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5ECU7-6</id>
            <name evidence="1">f</name>
            <sequence type="described" ref="VSP_057617"/>
        </isoform>
        <isoform>
            <id>G5ECU7-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_057615"/>
        </isoform>
        <isoform>
            <id>G5ECU7-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5ECU7-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_057619"/>
        </isoform>
        <isoform>
            <id>G5ECU7-5</id>
            <name evidence="10">e</name>
            <sequence type="described" ref="VSP_057616"/>
        </isoform>
        <isoform>
            <id>G5ECU7-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_057618"/>
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    </comment>
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        <property type="nucleotide sequence ID" value="NM_001383910.2"/>
    </dbReference>
    <dbReference type="WormBase" id="T24H10.7d">
        <property type="protein sequence ID" value="CE41026"/>
        <property type="gene ID" value="WBGene00012005"/>
        <property type="gene designation" value="jun-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="19570917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="ACB41727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAB76416.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T24H10.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T24H10.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T24H10.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T24H10.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T24H10.7e"/>
        </source>
    </evidence>
    <sequence length="155" mass="17222" checksum="B00A7AEA1486F37C" modified="2011-12-14" version="1">MLNWGHHHNSYDEPSASSSSGSSSSSVAANLSVSYNSDSRNQGCMGGGQYSGNIGGGGGGYGDYSHIDPINMMALDDQEKKKLERKRARNRQAATKCRQKKMDRIKELEEQVLHEKHRGQRLDAELLELNRALEHFRRTVEHHSGNGCPNNSIRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-04-29" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>G5ECU7-5</accession>
    <name>JUN_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isoform e of Transcription factor jun-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Transcription factor AP-1 subunit jun-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">jun-1</name>
        <name evidence="6" type="ORF">T24H10.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Development" volume="134" first="3999" last="4009">
            <title>Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development.</title>
            <authorList>
                <person name="Oommen K.S."/>
                <person name="Newman A.P."/>
            </authorList>
            <dbReference type="PubMed" id="17942488"/>
            <dbReference type="DOI" id="10.1242/dev.002741"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PROBABLE INTERACTION WITH FOS-1</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="3888" last="3895">
            <title>Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation.</title>
            <authorList>
                <person name="Hiatt S.M."/>
                <person name="Duren H.M."/>
                <person name="Shyu Y.J."/>
                <person name="Ellis R.E."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
                <person name="Kariya K."/>
                <person name="Kerppola T.K."/>
                <person name="Hu C.D."/>
            </authorList>
            <dbReference type="PubMed" id="19570917"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-08-0833"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D; E AND F)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2014" name="Genesis" volume="52" first="29" last="38">
            <title>C. elegans nuclear receptor NHR-6 functionally interacts with the jun-1 transcription factor during spermatheca development.</title>
            <authorList>
                <person name="Gissendanner C.R."/>
                <person name="Cardin D."/>
                <person name="Dubose C.J."/>
                <person name="El Sayed M."/>
                <person name="Harmson J.S."/>
                <person name="Praslicka B."/>
                <person name="Rowan B.G."/>
            </authorList>
            <dbReference type="PubMed" id="24178943"/>
            <dbReference type="DOI" id="10.1002/dvg.22723"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5ECU7-5</id>
            <name evidence="10">e</name>
            <sequence type="described" ref="VSP_057616"/>
        </isoform>
        <isoform>
            <id>G5ECU7-6</id>
            <name evidence="1">f</name>
            <sequence type="described" ref="VSP_057617"/>
        </isoform>
        <isoform>
            <id>G5ECU7-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5ECU7-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_057619"/>
        </isoform>
        <isoform>
            <id>G5ECU7-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_057615"/>
        </isoform>
        <isoform>
            <id>G5ECU7-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_057618"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001129827.1">
        <property type="nucleotide sequence ID" value="NM_001136355.4"/>
    </dbReference>
    <dbReference type="WormBase" id="T24H10.7e">
        <property type="protein sequence ID" value="CE43044"/>
        <property type="gene ID" value="WBGene00012005"/>
        <property type="gene designation" value="jun-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <feature type="sequence conflict" description="In Ref. 1; ACB41731." evidence="2" ref="1">
        <original>I</original>
        <variation>T</variation>
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; ACB41731." evidence="2" ref="1">
        <original>F</original>
        <variation>Y</variation>
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="19570917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="ACB41727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAB76416.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T24H10.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T24H10.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T24H10.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T24H10.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T24H10.7e"/>
        </source>
    </evidence>
    <sequence length="164" mass="18818" checksum="330F3D80C86CBCA5" modified="2011-12-14" version="1">MLNYQPPQWMNSLMNSNIPSSLTLTPTPQFPIMFSSTSPFNFCTSDSSSSPISADSTPKSSPFFGDANPKFPFFNFMNGDSMALDDQEKKKLERKRARNRQAATKCRQKKMDRIKELEEQVLHEKHRGQRLDAELLELNRALEHFRRTVEHHSGNGCPNNSIRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-04-29" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>G5ECU7-6</accession>
    <name>JUN_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isoform f of Transcription factor jun-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Transcription factor AP-1 subunit jun-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">jun-1</name>
        <name evidence="6" type="ORF">T24H10.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2007" name="Development" volume="134" first="3999" last="4009">
            <title>Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development.</title>
            <authorList>
                <person name="Oommen K.S."/>
                <person name="Newman A.P."/>
            </authorList>
            <dbReference type="PubMed" id="17942488"/>
            <dbReference type="DOI" id="10.1242/dev.002741"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PROBABLE INTERACTION WITH FOS-1</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="3888" last="3895">
            <title>Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation.</title>
            <authorList>
                <person name="Hiatt S.M."/>
                <person name="Duren H.M."/>
                <person name="Shyu Y.J."/>
                <person name="Ellis R.E."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
                <person name="Kariya K."/>
                <person name="Kerppola T.K."/>
                <person name="Hu C.D."/>
            </authorList>
            <dbReference type="PubMed" id="19570917"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-08-0833"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D; E AND F)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2014" name="Genesis" volume="52" first="29" last="38">
            <title>C. elegans nuclear receptor NHR-6 functionally interacts with the jun-1 transcription factor during spermatheca development.</title>
            <authorList>
                <person name="Gissendanner C.R."/>
                <person name="Cardin D."/>
                <person name="Dubose C.J."/>
                <person name="El Sayed M."/>
                <person name="Harmson J.S."/>
                <person name="Praslicka B."/>
                <person name="Rowan B.G."/>
            </authorList>
            <dbReference type="PubMed" id="24178943"/>
            <dbReference type="DOI" id="10.1002/dvg.22723"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5ECU7-5</id>
            <name evidence="10">e</name>
            <sequence type="described" ref="VSP_057616"/>
        </isoform>
        <isoform>
            <id>G5ECU7-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5ECU7-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_057618"/>
        </isoform>
        <isoform>
            <id>G5ECU7-6</id>
            <name evidence="1">f</name>
            <sequence type="described" ref="VSP_057617"/>
        </isoform>
        <isoform>
            <id>G5ECU7-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_057615"/>
        </isoform>
        <isoform>
            <id>G5ECU7-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_057619"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022368.1">
        <property type="nucleotide sequence ID" value="NM_001027197.5"/>
    </dbReference>
    <dbReference type="WormBase" id="T24H10.7c">
        <property type="protein sequence ID" value="CE16461"/>
        <property type="gene ID" value="WBGene00012005"/>
        <property type="gene designation" value="jun-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="19570917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="ACB41727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAB76416.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T24H10.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T24H10.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T24H10.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T24H10.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T24H10.7e"/>
        </source>
    </evidence>
    <sequence length="101" mass="12093" checksum="2384E1A5F9AC96B3" modified="2011-12-14" version="1">MVWSSETFGMTPEEQIEWMALDDQEKKKLERKRARNRQAATKCRQKKMDRIKELEEQVLHEKHRGQRLDAELLELNRALEHFRRTVEHHSGNGCPNNSIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZD2</accession>
    <name>H2KZD2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">plpp-1.1</name>
        <name evidence="8" type="ORF">CELE_F53C3.13</name>
        <name evidence="10" type="ORF">F53C3.13</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD67683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_872026.1">
        <property type="nucleotide sequence ID" value="NM_182226.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZD2"/>
    <dbReference type="PeptideAtlas" id="H2KZD2"/>
    <dbReference type="GeneID" id="173734"/>
    <dbReference type="AGR" id="WB:WBGene00018756"/>
    <dbReference type="CTD" id="173734"/>
    <dbReference type="WormBase" id="F53C3.13c">
        <property type="protein sequence ID" value="CE31954"/>
        <property type="gene ID" value="WBGene00018756"/>
        <property type="gene designation" value="plpp-1.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_3_3_1"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018756">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZD2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000031">
        <property type="entry name" value="PhosphoLipid PhosPhatase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF201">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="113"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD67683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F53C3.13c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZD2"/>
        </source>
    </evidence>
    <sequence length="340" mass="39102" checksum="866191F93F70211B" modified="2012-03-21" version="1">MSDNNTIRMSRVLCDFLVLTLIAIPLYVFHEFIPPVRRGFYCDDESIRYPFRDSKVTRQMLIVVGLLIPILLILATELFRTLAWEKKCETEFKTYHVRNHSVHRLVVRLYCFIGYFFVGVCFNQLMVDIAKYTIGRQRPHFMDVCRPDIGYQTCSQPDLYITDFKCTTTDTKKIHEAQLSFYSGHSAFSFYAAWFTSLYLQARLFRPLFSRLLLPVIQFLLFGGAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFVALFVAEVFKRREIPSCGPSNEFGLIRMDRPDGVSNANGNGSNTVVSTQHVIVSEVDPANQRLLWTPSGPASKNYQDERYMDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZD4</accession>
    <name>H2KZD4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cortactin-binding protein-2 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="ORF">C49H3.6</name>
        <name evidence="5" type="ORF">CELE_C49H3.6</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD67708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_501315.1">
        <property type="nucleotide sequence ID" value="NM_068914.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZD4"/>
    <dbReference type="SMR" id="H2KZD4"/>
    <dbReference type="PeptideAtlas" id="H2KZD4"/>
    <dbReference type="GeneID" id="177577"/>
    <dbReference type="KEGG" id="cel:CELE_C49H3.6"/>
    <dbReference type="AGR" id="WB:WBGene00016792"/>
    <dbReference type="CTD" id="177577"/>
    <dbReference type="WormBase" id="C49H3.6b">
        <property type="protein sequence ID" value="CE29380"/>
        <property type="gene ID" value="WBGene00016792"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513119_0_0_1"/>
    <dbReference type="OrthoDB" id="6021133at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016792">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZD4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050719">
        <property type="entry name" value="Cortactin-Actin_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019131">
        <property type="entry name" value="Cortactin-binding_p2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23166:SF5">
        <property type="entry name" value="CTTNBP2 N-TERMINAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23166">
        <property type="entry name" value="FILAMIN/GPBP-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09727">
        <property type="entry name" value="CortBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cortactin-binding protein-2 N-terminal" evidence="4">
        <location>
            <begin position="43"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD67708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C49H3.6b"/>
        </source>
    </evidence>
    <sequence length="498" mass="55662" checksum="F9D782804A44C982" modified="2012-03-21" version="1">MPNLLDDSFDPTFQSTSKKLVLPSIRKVQPEYDNLPEEQGVNDFSSDELMKLLSFMEGEVQAREDVIDHLKRERTKILLSEAKYGKLNMNDPFAALRRDSAITGEQIDEEKIVQMYESQVDQLDKMMAVQKQSQRNAAVLLVALEKKQYKLVKKLEADREAKIRYAKQGDDLVAHLEKERNQLQQQIEFHIEEKRKAEIAKDKMEMTLGNEKKRHESIVLYLIQERKQMLLKMHELRVKAEQIMLQNQNDPTKPGPSSALSERELIEELKKEVTFLRAERESLTKTQKMVKTENLSLRETVRGQEADLQMLRRNLTLTGAKMSIDKPGNVLPQLPPDTGSLIMANRGAKPAVNRQQPAPPPVARLPNSATFPTEKSRLPRAPPPAVTTPVPRMSIGSLPASSSNVPRTMSSPVKKTPVMGVSSTAVRRPQSAATTTMPTTSVITNTSAVMPLSPDLEQLEAAIQSMNAGPSSNVASERKLSGTVKRNGILAKAFGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZD7</accession>
    <name>H2KZD7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_T03F1.6</name>
        <name evidence="1 3" type="ORF">T03F1.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD67790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491239.1">
        <property type="nucleotide sequence ID" value="NM_058838.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZD7"/>
    <dbReference type="GeneID" id="171961"/>
    <dbReference type="AGR" id="WB:WBGene00020188"/>
    <dbReference type="CTD" id="171961"/>
    <dbReference type="WormBase" id="T03F1.6a">
        <property type="protein sequence ID" value="CE13106"/>
        <property type="gene ID" value="WBGene00020188"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_811929_0_0_1"/>
    <dbReference type="OrthoDB" id="5843094at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020188">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZD7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD67790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T03F1.6a"/>
        </source>
    </evidence>
    <sequence length="342" mass="39163" checksum="7DD90BD75957B89E" modified="2012-03-21" version="1">MIPPTTNSLGIFGELPVDLLSSVCRHLPMVDVVTVSMLDSRLGGFVERIIYREIKALRVEVHDNDYSVYFINKDSRVTNLNLTGCDWEDVIKYGTCIEKLELNICPGKSTSQLFQTIKRASFTLRSLKINVLAGADKCVQKMKNLEKRCFDLVSRHSSSLRHLELSTSDEQHVYADLNIATSSMRLTYHQPAEPKPSEQTRHGQNHSFMYIMFHDYLNHHTISNVTLEIASKYDANLALQKAYQAALPHSRRRFLESLTIEFGNSLKAVTEEEMKRVLLCHVDEFHHTTPNLQHFHCSLPHDEIDLSQEFLALLNEPVRKTRQSKSSCPYNSTISLRAVRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZD8</accession>
    <name>H2KZD8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">srv-5</name>
        <name evidence="7" type="ORF">CELE_F48D6.2</name>
        <name evidence="9" type="ORF">F48D6.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024688.1">
        <property type="nucleotide sequence ID" value="NM_001029517.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZD8"/>
    <dbReference type="SMR" id="H2KZD8"/>
    <dbReference type="GeneID" id="185979"/>
    <dbReference type="KEGG" id="cel:CELE_F48D6.2"/>
    <dbReference type="AGR" id="WB:WBGene00005716"/>
    <dbReference type="CTD" id="185979"/>
    <dbReference type="WormBase" id="F48D6.2a">
        <property type="protein sequence ID" value="CE07259"/>
        <property type="gene ID" value="WBGene00005716"/>
        <property type="gene designation" value="srv-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072404_0_0_1"/>
    <dbReference type="OrthoDB" id="5844602at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005716">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZD8">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31552:SF31">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD67845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F48D6.2a"/>
        </source>
    </evidence>
    <sequence length="333" mass="38150" checksum="B2A5ED557CDBA5C9" modified="2012-03-21" version="1">MPALQWFLFISSLISILIYTMIVFTLKRHRSNALLGGSFFRIVEMQYYAELFFFVEFSITMRFRKYSSLYAFFEPDTEFHGIIPRIVSGFHYYIKIVVYIGYLTFALNRLTSALNISSYNSIWTPKLLQRVRIVKWALPLIGILPTHAWPGFTYWFMITSSSIRLTNDSLSTALVAYVDGICCLGTCVFCMICYTATCFLIRKNWKRVKTDTVFRKNNAQSAAERSLLVSAILSFIVLILNTAVQVVTILISWGGATTLLFVQDLSYPMIDLMYSHFPWALLVTSGVLRKQMIYDTKIFLRTAFKLDDASVNTIRVGHTVSPATQKTTNRTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZD9</accession>
    <name>H2KZD9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F48D6.4</name>
        <name evidence="2 4" type="ORF">F48D6.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508724.1">
        <property type="nucleotide sequence ID" value="NM_076323.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZD9"/>
    <dbReference type="PeptideAtlas" id="H2KZD9"/>
    <dbReference type="GeneID" id="180697"/>
    <dbReference type="AGR" id="WB:WBGene00018602"/>
    <dbReference type="CTD" id="180697"/>
    <dbReference type="WormBase" id="F48D6.4b">
        <property type="protein sequence ID" value="CE07261"/>
        <property type="gene ID" value="WBGene00018602"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2656708_0_0_1"/>
    <dbReference type="OrthoDB" id="5839397at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018602">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZD9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD67849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F48D6.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZD9"/>
        </source>
    </evidence>
    <sequence length="76" mass="8613" checksum="57BDEBC7CDE52B40" modified="2012-03-21" version="1">MSTPKLVRVAQSAVFNQFMTREAISSATFRPAEPKMMDQPKMNIRIHDESTHLKFGFPKTEKVSNPVPETVTTSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZF1</accession>
    <name>H2KZF1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAM69 protein-kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C53D5.1</name>
        <name evidence="3" type="ORF">CELE_C53D5.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD67931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_490713.1">
        <property type="nucleotide sequence ID" value="NM_058312.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZF1"/>
    <dbReference type="GeneID" id="171618"/>
    <dbReference type="AGR" id="WB:WBGene00016902"/>
    <dbReference type="CTD" id="171618"/>
    <dbReference type="WormBase" id="C53D5.1b">
        <property type="protein sequence ID" value="CE27884"/>
        <property type="gene ID" value="WBGene00016902"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8543887at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016902">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZF1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093:SF2">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FAM69 protein-kinase" evidence="2">
        <location>
            <begin position="223"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD67931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C53D5.1b"/>
        </source>
    </evidence>
    <sequence length="418" mass="48019" checksum="E9093144C2D27969" modified="2012-03-21" version="1">MYSSSSRRPFRRLVPLKMAQGRTATDYAGQDYDECYDRCEQECGEEAWRIACCSRVGKIAILVMSIIVLYLIISALTPSESTHKTDLNEPRPGINLTRANQVLTGLCDAYERGDVSGDSCNRLCYDRNWLVTDFYEGHKTVVIVKDGGQIAVYKSTKPFMDQFDEPKDHLTDAEFSDRVVDMVNDELRLGWPKHYRRHLMETVWPTLLRTKGEAMSKADRRSLWALLKQPEFILFRVLPLTRVTPKLIGTCGHMYQTESLVAFKMKGYYTNLKAKILVHVMGTLKLLYEFLDEPLQWCDVRFDNLGLSADYPKRFALMDGDMVYTKSKLDSLLKGRPCESDNDCKIGDCEARCTSNMVCSSRSNGNLEVFCDKLVNKLFANQWSKNNKYLVACRDTGRNITTRLNELRLTWSWNLPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZF2</accession>
    <name>H2KZF2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAM69 protein-kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C53D5.1</name>
        <name evidence="3" type="ORF">CELE_C53D5.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD67937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001248830.1">
        <property type="nucleotide sequence ID" value="NM_001261901.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZF2"/>
    <dbReference type="GeneID" id="171618"/>
    <dbReference type="KEGG" id="cel:CELE_C53D5.1"/>
    <dbReference type="AGR" id="WB:WBGene00016902"/>
    <dbReference type="CTD" id="171618"/>
    <dbReference type="WormBase" id="C53D5.1d">
        <property type="protein sequence ID" value="CE44411"/>
        <property type="gene ID" value="WBGene00016902"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8543887at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016902">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZF2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093:SF2">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="FAM69 protein-kinase" evidence="2">
        <location>
            <begin position="194"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD67937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C53D5.1d"/>
        </source>
    </evidence>
    <sequence length="389" mass="44654" checksum="61503829F8E08B8C" modified="2012-03-21" version="1">MFKFIIKLSCEQECGEEAWRIACCSRVGKIAILVMSIIVLYLIISALTPSESTHKTDLNEPRPGINLTRANQVLTGLCDAYERGDVSGDSCNRLCYDRNWLVTDFYEGHKTVVIVKDGGQIAVYKSTKPFMDQFDEPKDHLTDAEFSDRVVDMVNDELRLGWPKHYRRHLMETVWPTLLRTKGEAMSKADRRSLWALLKQPEFILFRVLPLTRVTPKLIGTCGHMYQTESLVAFKMKGYYTNLKAKILVHVMGTLKLLYEFLDEPLQWCDVRFDNLGLSADYPKRFALMDGDMVYTKSKLDSLLKGRPCESDNDCKIGDCEARCTSNMVCSSRSNGNLEVFCDKLVNKLFANQWSKNNKYLVACRDTGRNITTRLNELRLTWSWNLPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZG8</accession>
    <name>H2KZG8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nmtn-1</name>
        <name evidence="2" type="ORF">CELE_K06A5.8</name>
        <name evidence="4" type="ORF">K06A5.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD68119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370607.1">
        <property type="nucleotide sequence ID" value="NM_001383257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZG8"/>
    <dbReference type="SMR" id="H2KZG8"/>
    <dbReference type="GeneID" id="172355"/>
    <dbReference type="KEGG" id="cel:CELE_K06A5.8"/>
    <dbReference type="AGR" id="WB:WBGene00019434"/>
    <dbReference type="CTD" id="172355"/>
    <dbReference type="WormBase" id="K06A5.8d">
        <property type="protein sequence ID" value="CE33139"/>
        <property type="gene ID" value="WBGene00019434"/>
        <property type="gene designation" value="nmtn-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_487659_0_0_1"/>
    <dbReference type="OrthoDB" id="187712at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019434">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZG8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="503"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD68119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K06A5.8d"/>
        </source>
    </evidence>
    <sequence length="559" mass="61033" checksum="BD7C39550268A23E" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZH6</accession>
    <name>H2KZH6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein phosphatase 1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="ORF">CC8.2</name>
        <name evidence="6" type="ORF">CELE_CC8.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">Bristol N2</strain>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="CBM21_dom"/>
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    </dbReference>
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        <property type="entry name" value="Pase-1_reg-su_3B/C/D_met"/>
    </dbReference>
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        <property type="entry name" value="PP1_regulatory_subunit_3"/>
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            <begin position="127"/>
            <end position="234"/>
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            <begin position="247"/>
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            <begin position="261"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022600"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51159"/>
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            <dbReference type="EMBL" id="CCD68223.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="CC8.2a"/>
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    </evidence>
    <sequence length="295" mass="33311" checksum="9CE0FFD48CD2D457" modified="2012-03-21" version="1">MKTKVLFYRPASTGPLWVPSDDDEEEDVLPALRCTRSKTLPSALRRSRSKQSVKRVRFADSLGLDLENLQYFVKEDLHLQKFNIHFSTPSSSTPPPQLPHFPKQLINQPAPRLVLHNFPYRSEQEYQVKTRDSRVCVAALRASGSSIVGQVNLLNVAFDKVVVVRYTIDGWATQDEIVASYSHRLFDTEDIDAFNFTIAIPVKLSEGKCEFCVQYQVAGAEFWDNNGGDNYIVNVSTKGPSSPFTRCYGASTGLPDAPRGSTRRQQQRRWGRALEESDEETPYVSSAPRRGAHFH</sequence>
</entry>
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            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="H2KZI2"/>
    <dbReference type="PaxDb" id="6239-F09E10.7a.1"/>
    <dbReference type="PeptideAtlas" id="H2KZI2"/>
    <dbReference type="AGR" id="WB:WBGene00017297"/>
    <dbReference type="WormBase" id="F09E10.7a">
        <property type="protein sequence ID" value="CE34536"/>
        <property type="gene ID" value="WBGene00017297"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128796_1_1_1"/>
    <dbReference type="OrthoDB" id="5970825at2759"/>
    <dbReference type="PhylomeDB" id="H2KZI2"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017297">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZI2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF4440"/>
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    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
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        <property type="entry name" value="DUF4440 DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR31664">
        <property type="entry name" value="PROTEIN CBG16427"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
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    </dbReference>
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        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
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            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCD68286.1"/>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0007829" key="5">
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            <dbReference type="PeptideAtlas" id="H2KZI2"/>
        </source>
    </evidence>
    <sequence length="109" mass="11896" checksum="DD3C49645FC7317B" modified="2012-03-21" version="1">MKAFNAGDAAGAASVYDPDGYFMPNGRNPVKGRSGIEAYFKEDMADGVQTAQIITEEVNGGGDWAFERGSYHLDGTKGRESGAYLQIWKKVEGVWLIHNDCFNVIKNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZI3</accession>
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        <submittedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </submittedName>
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        <name evidence="4 6" type="primary">zfp-3</name>
        <name evidence="4" type="ORF">CELE_W05H7.4</name>
        <name evidence="6" type="ORF">W05H7.4</name>
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    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
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    <dbReference type="PeptideAtlas" id="H2KZI3"/>
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    <dbReference type="AGR" id="WB:WBGene00021047"/>
    <dbReference type="CTD" id="180479"/>
    <dbReference type="WormBase" id="W05H7.4b">
        <property type="protein sequence ID" value="CE35047"/>
        <property type="gene ID" value="WBGene00021047"/>
        <property type="gene designation" value="zfp-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876176at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021047">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZI3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="467"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="467"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD68295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="W05H7.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZI3"/>
        </source>
    </evidence>
    <sequence length="663" mass="73985" checksum="8DC7651B412E0A72" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZI4</accession>
    <name>H2KZI4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">zfp-3</name>
        <name evidence="3" type="ORF">CELE_W05H7.4</name>
        <name evidence="5" type="ORF">W05H7.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD68296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370614.1">
        <property type="nucleotide sequence ID" value="NM_001383527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZI4"/>
    <dbReference type="GeneID" id="180479"/>
    <dbReference type="AGR" id="WB:WBGene00021047"/>
    <dbReference type="CTD" id="180479"/>
    <dbReference type="WormBase" id="W05H7.4c">
        <property type="protein sequence ID" value="CE38431"/>
        <property type="gene ID" value="WBGene00021047"/>
        <property type="gene designation" value="zfp-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1278650_0_0_1"/>
    <dbReference type="OrthoDB" id="5876176at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021047">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZI4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD68296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W05H7.4c"/>
        </source>
    </evidence>
    <sequence length="216" mass="24902" checksum="FF325985DFAC713D" modified="2012-03-21" version="1">MADVYTPTKTMDGAFLPAVGSPNTSIDSPAVYVPTPLTAPSTSKTTPVKPEDQTTRQKYGGTWKLRHLGMRWRCALPTRRFPLSQPLFLCSVDTTIHILMNYRTLQNFSKILKGLGKMGKCNFKSGQKPRFIIKKRLWIPGNYGHSYGSLFSIVNPHHFSDSPISCSPCFFYVSDFFFFSIFLCVRSFFADALSFIWNILQWFRLQSRAKWRRRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZI5</accession>
    <name>H2KZI5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">zfp-3</name>
        <name evidence="1" type="ORF">CELE_W05H7.4</name>
        <name evidence="3" type="ORF">W05H7.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD68297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367703.1">
        <property type="nucleotide sequence ID" value="NM_001380907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZI5"/>
    <dbReference type="SMR" id="H2KZI5"/>
    <dbReference type="GeneID" id="180479"/>
    <dbReference type="AGR" id="WB:WBGene00021047"/>
    <dbReference type="CTD" id="180479"/>
    <dbReference type="WormBase" id="W05H7.4d">
        <property type="protein sequence ID" value="CE33719"/>
        <property type="gene ID" value="WBGene00021047"/>
        <property type="gene designation" value="zfp-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3336093_0_0_1"/>
    <dbReference type="OrthoDB" id="5876176at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021047">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZI5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD68297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="W05H7.4d"/>
        </source>
    </evidence>
    <sequence length="38" mass="4094" checksum="66B69122BADE40A1" modified="2012-03-21" version="1">MADVYTPTKTMDGAFLPAVGSPNTSIDSPGKSSEFYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZJ0</accession>
    <name>H2KZJ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CRIB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CELE_F09F7.5</name>
        <name evidence="13 15" type="ORF">F09F7.5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC42SE/SPEC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD68387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZJ0"/>
    <dbReference type="PeptideAtlas" id="H2KZJ0"/>
    <dbReference type="AGR" id="WB:WBGene00017302"/>
    <dbReference type="WormBase" id="F09F7.5b">
        <property type="protein sequence ID" value="CE29259"/>
        <property type="gene ID" value="WBGene00017302"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5832373at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017302">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZJ0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039056">
        <property type="entry name" value="SPEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502:SF9">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="12">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD68387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F09F7.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZJ0"/>
        </source>
    </evidence>
    <sequence length="582" mass="64118" checksum="C4F07963DE2493E2" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZJ2</accession>
    <name>H2KZJ2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_R02F2.1</name>
        <name evidence="4 6" type="ORF">R02F2.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD68393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_498176.1">
        <property type="nucleotide sequence ID" value="NM_065775.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZJ2"/>
    <dbReference type="SMR" id="H2KZJ2"/>
    <dbReference type="GeneID" id="175757"/>
    <dbReference type="AGR" id="WB:WBGene00019831"/>
    <dbReference type="CTD" id="175757"/>
    <dbReference type="WormBase" id="R02F2.1a">
        <property type="protein sequence ID" value="CE29436"/>
        <property type="gene ID" value="WBGene00019831"/>
    </dbReference>
    <dbReference type="OrthoDB" id="769138at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019831">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZJ2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000171">
        <property type="entry name" value="Protein CBG05210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000172">
        <property type="entry name" value="Protein CBG05210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="65"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD68393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="R02F2.1a"/>
        </source>
    </evidence>
    <sequence length="309" mass="34529" checksum="532AA8C29366DE0C" modified="2012-03-21" version="1">MNEDFDGLTSGSSAAAGKLMQDGISSTQLLQMLLQREKLLYQNYPLSLASGEGMIGWRERNRECAWMCAAAKRIGLEMDAASLAVSIFDRVVTSVKIPGKYVNCVAVGSLSIAKKLCEDHEEDAPVFLGRLRLEYSAQELKRMEIKILEVLRWDAHLPNLNRFVECLLSELDAAFLLPSIKKHLDFLLCDSTLTSNFRWSVLALSTVSLLVEATNKHWQYPINALARLCKIPMSEVNRCRVKVSNLWSRHVLPMPSTFHLLADLDDQDSDMDVDYPLAYDSSPHPQAPSAEASEYITSPAPRALQPTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZJ6</accession>
    <name>H2KZJ6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mctp-1</name>
        <name evidence="6" type="ORF">CELE_D2092.1</name>
        <name evidence="8" type="ORF">D2092.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD68501.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001382287.1">
        <property type="nucleotide sequence ID" value="NM_001395339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZJ6"/>
    <dbReference type="SMR" id="H2KZJ6"/>
    <dbReference type="GeneID" id="172382"/>
    <dbReference type="AGR" id="WB:WBGene00017063"/>
    <dbReference type="CTD" id="172382"/>
    <dbReference type="WormBase" id="D2092.1a">
        <property type="protein sequence ID" value="CE54335"/>
        <property type="gene ID" value="WBGene00017063"/>
        <property type="gene designation" value="mctp-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011170_0_2_1"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017063">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZJ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04042">
        <property type="entry name" value="C2A_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08376">
        <property type="entry name" value="C2B_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08377">
        <property type="entry name" value="C2C_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000167">
        <property type="entry name" value="Multiple C2 domains, transmembrane 2a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000174">
        <property type="entry name" value="Multiple C2 domains, transmembrane 2a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000256">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="648"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="39"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="196"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="348"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD68501.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="D2092.1a"/>
        </source>
    </evidence>
    <sequence length="724" mass="83321" checksum="213F1F6E832A3D4D" modified="2022-01-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZJ9</accession>
    <name>H2KZJ9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lec-12</name>
        <name evidence="5" type="ORF">CELE_DC2.3</name>
        <name evidence="7" type="ORF">DC2.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD68542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023758.2">
        <property type="nucleotide sequence ID" value="NM_001028587.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZJ9"/>
    <dbReference type="SMR" id="H2KZJ9"/>
    <dbReference type="GeneID" id="178548"/>
    <dbReference type="KEGG" id="cel:CELE_DC2.3"/>
    <dbReference type="AGR" id="WB:WBGene00017080"/>
    <dbReference type="CTD" id="178548"/>
    <dbReference type="WormBase" id="DC2.3a">
        <property type="protein sequence ID" value="CE39484"/>
        <property type="gene ID" value="WBGene00017080"/>
        <property type="gene designation" value="lec-12"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037794_3_1_1"/>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017080">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZJ9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000360">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF171">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD68542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="DC2.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZJ9"/>
        </source>
    </evidence>
    <sequence length="178" mass="19911" checksum="B964384EF5D1D973" modified="2012-03-21" version="1">MSEPSAPPDEAESTIRSPDLPFVSSIVGGLFAGRAIVVSGMVLPGFASDRKRFQIDLCCGLLIDGDHMDNKALHFNPRFDAKTGWFSGPGDDKLVINSFVSGRWGNEERFDNPFKEGEPFQIRIMVFEKYFKISASGKHMCDFPHRVPVESIRTISINGNIRVDYVEFHPPEDSMPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZK2</accession>
    <name>H2KZK2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_E02C12.8</name>
        <name evidence="1 3" type="ORF">E02C12.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD68593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZK2"/>
    <dbReference type="AGR" id="WB:WBGene00017093"/>
    <dbReference type="WormBase" id="E02C12.8b">
        <property type="protein sequence ID" value="CE32850"/>
        <property type="gene ID" value="WBGene00017093"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2661504_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017093">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZK2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF7">
        <property type="entry name" value="CHK DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD68593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="E02C12.8b"/>
        </source>
    </evidence>
    <sequence length="77" mass="8728" checksum="C516988C999D4C90" modified="2012-03-21" version="1">MSLYEPADGILETHVTWEDVEKDLQQSLGTRATFGENKRATNISDLKGFMSRIACLEPDWQNIEEGKELPSKFALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZL1</accession>
    <name>H2KZL1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_W04B5.3</name>
        <name evidence="5 7" type="ORF">W04B5.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD68651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZL1"/>
    <dbReference type="SMR" id="H2KZL1"/>
    <dbReference type="IntAct" id="H2KZL1">
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    </dbReference>
    <dbReference type="PeptideAtlas" id="H2KZL1"/>
    <dbReference type="AGR" id="WB:WBGene00021020"/>
    <dbReference type="WormBase" id="W04B5.3c">
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        <property type="gene ID" value="WBGene00021020"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871144at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
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    <dbReference type="Bgee" id="WBGene00021020">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZL1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="4">
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            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD68651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="W04B5.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZL1"/>
        </source>
    </evidence>
    <sequence length="353" mass="38063" checksum="CE5335A05A4C840D" modified="2012-03-21" version="1">MQNFVLPTMPFRRDIPAGFPVGTTFKLTGKPYEDIQKSIFVIFNTNNGDQALRVELVLVQPSKLKIDCTVSQKKSTAVETLVVCPLNQRAVLKIITSQHSFQILFNESKVADFVHRVDPTLVKSVLVSGPMITEDVTITPGTSQPLPSYEQATSPPVEMMANMNLGTPQKVPLPDNEPFPPAPMPQPAAPPTQITMTTAPGSTGTTSSSFYFTGGSQGFSNHPYPLPGLIDNSTHASQQNPVGTLPPQTSMPSAPPITQAPPTPAGAAYTSPYTSVPMPQPPSSVPLSYTPAPTPSVPYTVTYPQSANSTPGIPQPLPQQMSRQQAPIYQNQQQMPPGYNPYLQQQQQQMAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2V2</accession>
    <name>H9G2V2_CAEEL</name>
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        <recommendedName>
            <fullName evidence="12">Calcium-dependent secretion activator</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Uncoordinated protein 31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">unc-31</name>
        <name evidence="18" type="ORF">CELE_ZK897.1</name>
        <name evidence="20" type="ORF">ZK897.1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255663.1">
        <property type="nucleotide sequence ID" value="NM_001268734.3"/>
    </dbReference>
    <dbReference type="SMR" id="H9G2V2"/>
    <dbReference type="PeptideAtlas" id="H9G2V2"/>
    <dbReference type="GeneID" id="178233"/>
    <dbReference type="AGR" id="WB:WBGene00006767"/>
    <dbReference type="CTD" id="178233"/>
    <dbReference type="WormBase" id="ZK897.1i">
        <property type="protein sequence ID" value="CE47452"/>
        <property type="gene ID" value="WBGene00006767"/>
        <property type="gene designation" value="unc-31"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="PhylomeDB" id="H9G2V2"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006767">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2V2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="project" value="WormBase"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0000315"/>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="SynGO"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001820">
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
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    </dbReference>
    <dbReference type="Pfam" id="PF25341">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="437"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
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            <end position="682"/>
        </location>
    </feature>
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            <begin position="971"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
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        </source>
    </evidence>
    <sequence length="1385" mass="157058" checksum="606EBB5368A86BE4" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2V3</accession>
    <name>H9G2V3_CAEEL</name>
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        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
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        <name evidence="18" type="ORF">CELE_ZK897.1</name>
        <name evidence="20" type="ORF">ZK897.1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255665.1">
        <property type="nucleotide sequence ID" value="NM_001268736.3"/>
    </dbReference>
    <dbReference type="SMR" id="H9G2V3"/>
    <dbReference type="GeneID" id="178233"/>
    <dbReference type="AGR" id="WB:WBGene00006767"/>
    <dbReference type="CTD" id="178233"/>
    <dbReference type="WormBase" id="ZK897.1h">
        <property type="protein sequence ID" value="CE47155"/>
        <property type="gene ID" value="WBGene00006767"/>
        <property type="gene designation" value="unc-31"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006767">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2V3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="SynGO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001820">
        <property type="term" value="P:serotonin secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd01234">
        <property type="entry name" value="PH_CADPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000343">
        <property type="entry name" value="Calcium-dependent secretion activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000239">
        <property type="entry name" value="Calcium-dependent secretion activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057457">
        <property type="entry name" value="CAPS_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25341">
        <property type="entry name" value="C2_CAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="418"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="557"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="17">
        <location>
            <begin position="952"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCG28131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="ZK897.1h"/>
        </source>
    </evidence>
    <sequence length="1366" mass="154839" checksum="83FAFC80EF3E9C95" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2W1</accession>
    <name>H9G2W1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="ORF">AC3.5</name>
        <name evidence="6" type="ORF">CELE_AC3.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28217.1"/>
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    <dbReference type="RefSeq" id="NP_001256215.1">
        <property type="nucleotide sequence ID" value="NM_001269286.3"/>
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    <dbReference type="AGR" id="WB:WBGene00007071"/>
    <dbReference type="CTD" id="179447"/>
    <dbReference type="WormBase" id="AC3.5b">
        <property type="protein sequence ID" value="CE47308"/>
        <property type="gene ID" value="WBGene00007071"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276388_0_0_1"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007071">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2W1">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF201">
        <property type="entry name" value="AMINOPEPTIDASE-LIKE PROTEIN AC3.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="5">
        <location>
            <begin position="156"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="3">
        <location>
            <begin position="317"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="4">
        <location>
            <begin position="621"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="962"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="962"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="974"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCG28217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="AC3.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2W1"/>
        </source>
    </evidence>
    <sequence length="983" mass="111050" checksum="CB9A26DEC9FB2690" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2W3</accession>
    <name>H9G2W3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">fig-1</name>
        <name evidence="2" type="ORF">CELE_F53B7.5</name>
        <name evidence="4" type="ORF">F53B7.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122946.2">
        <property type="nucleotide sequence ID" value="NM_001129474.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2W3"/>
    <dbReference type="SMR" id="H9G2W3"/>
    <dbReference type="GeneID" id="179523"/>
    <dbReference type="KEGG" id="cel:CELE_F53B7.5"/>
    <dbReference type="AGR" id="WB:WBGene00009968"/>
    <dbReference type="CTD" id="179523"/>
    <dbReference type="WormBase" id="F53B7.5a">
        <property type="protein sequence ID" value="CE47474"/>
        <property type="gene ID" value="WBGene00009968"/>
        <property type="gene designation" value="fig-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1857071_0_0_1"/>
    <dbReference type="OrthoDB" id="5873713at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009968">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2W3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31507:SF12">
        <property type="entry name" value="C6 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31507">
        <property type="entry name" value="PROTEIN CBG15923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003620729" evidence="1">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F53B7.5a"/>
        </source>
    </evidence>
    <sequence length="138" mass="14485" checksum="7301DA8BE5A3ECA2" modified="2012-05-16" version="1">MSLSPVALQTALLILSNSSATTLTDIPGSSKKLITGLNVTDFLDQVQKTTSTAAASDCSTSTWNAWQEWSTCTETCGSCGTQQRFRSCNKPVDTCTCSGSAFEKEYCNLAVCKFPLASCCSGFTPQSSGGTFVCLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2W4</accession>
    <name>H9G2W4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GST C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F55A11.6</name>
        <name evidence="3 5" type="ORF">F55A11.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256367.1">
        <property type="nucleotide sequence ID" value="NM_001269438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2W4"/>
    <dbReference type="SMR" id="H9G2W4"/>
    <dbReference type="GeneID" id="179613"/>
    <dbReference type="AGR" id="WB:WBGene00010079"/>
    <dbReference type="CTD" id="179613"/>
    <dbReference type="WormBase" id="F55A11.6d">
        <property type="protein sequence ID" value="CE47194"/>
        <property type="gene ID" value="WBGene00010079"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010079">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2W4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000310">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000077">
        <property type="entry name" value="Protein CBG23268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF256">
        <property type="entry name" value="GST C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="63"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="140"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F55A11.6d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2W4"/>
        </source>
    </evidence>
    <sequence length="271" mass="31607" checksum="9D27EB249BDE42CB" modified="2012-05-16" version="1">MTPSLALQYSITYALSPKFVKSSSSGRHLSVSVSSTTQKNFFQPSPVQSRKNKMDTMHGFLVPTYTLHDFDDGEECKVVRMIFQMSRVPYEFKHVHRDDYILEDYPFYALPTLEMNERKYGSVLSICRHLAWRYNLSGKTAYDDAQVDDIAEKVFEVRMKIKNWIDHIEHAADHACDEECTEEIAPRILTNTLFPCLERMLKSAASCWLVGHTMTWVDLLVACLVNPIIYHRPKLLQDFPLLYLHNEKVAHHDDLVGFLYHVRTRKFQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2W6</accession>
    <name>H9G2W6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane Bound O-Acyl transferase, MBOAT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">mboa-4</name>
        <name evidence="11" type="ORF">C08F8.4</name>
        <name evidence="9" type="ORF">CELE_C08F8.4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255543.1">
        <property type="nucleotide sequence ID" value="NM_001268614.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2W6"/>
    <dbReference type="SMR" id="H9G2W6"/>
    <dbReference type="GeneID" id="182414"/>
    <dbReference type="KEGG" id="cel:CELE_C08F8.4"/>
    <dbReference type="AGR" id="WB:WBGene00007446"/>
    <dbReference type="CTD" id="182414"/>
    <dbReference type="WormBase" id="C08F8.4c">
        <property type="protein sequence ID" value="CE47233"/>
        <property type="gene ID" value="WBGene00007446"/>
        <property type="gene designation" value="mboa-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007446">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2W6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF11">
        <property type="entry name" value="MEMBRANE BOUND O-ACYL TRANSFERASE, MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="456"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCG28250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C08F8.4c"/>
        </source>
    </evidence>
    <sequence length="496" mass="56429" checksum="C78BB71AA6ED4804" modified="2012-05-16" version="1">MSSLNEDVDESNHIFYDPVTLLRPVSRAISMNLDQLNFVTVLLLSFGLGYWFRVQFCDASRTTRAAVTTSVGLIFTYFCYGNAIAHLFINGFGSYLLMVSVPPQHVHKSVFAFAMGYLVLIHSYRWMYQKTYCLDVTGSMMVAVGKITLLASAITDGMGRDPKALNSGQKRDAVKETVIVGPMNHYSTWSAFLELKHVPKNEKTGKPYDPTSTAMKKFEAAIAFSVVYTILGSYLPMSLTNDPSINEYNLLIWWLITVAASTVHRLPYYFAWTISDSICNISGFGYDGLADETLEPKWSRTTNVKPLLVEFGQNYKEMVDNWNIWTVAWLRRVVYERVEGPYRTLAVYVTGAAWHGLAVGYYFSFLTSALFTLSAATFRRCMRHRFLGNSMHKLMYDIFGMLVSKFAIGYIHWPFYVMHFWPSLFMYRKLLMIPHFIALFIYLYLPQIFSPQPKSKITGPNASATSVNTDRISEISQRSSSRTSAIDVSTRTALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2W7</accession>
    <name>H9G2W7_CAEEL</name>
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        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">unc-30</name>
        <name evidence="12" type="ORF">B0564.10</name>
        <name evidence="10" type="ORF">CELE_B0564.10</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255701.1">
        <property type="nucleotide sequence ID" value="NM_001268772.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2W7"/>
    <dbReference type="SMR" id="H9G2W7"/>
    <dbReference type="GeneID" id="178265"/>
    <dbReference type="AGR" id="WB:WBGene00006766"/>
    <dbReference type="CTD" id="178265"/>
    <dbReference type="WormBase" id="B0564.10d">
        <property type="protein sequence ID" value="CE47394"/>
        <property type="gene ID" value="WBGene00006766"/>
        <property type="gene designation" value="unc-30"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_886337_0_0_1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006766">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2W7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="P:dorsal/ventral axon guidance"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="project" value="WormBase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882:SF3">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCG28290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="B0564.10d"/>
        </source>
    </evidence>
    <sequence length="181" mass="20120" checksum="12FDE49C42FE38F8" modified="2012-05-16" version="1">MACREEIAVWISLTEPRVRVWFKNRRAKWRKRERNYVIDNGQGTTKVTAQSLDPLGSLQNTFPQTLLQSSSSQLDDSAVTSSSFYGYGGAWQQNPYYSRNNQTTFNWQIKPQFQTIPMSPTTATSRFSTAANLAPLPTAQAAFSTSATSSNDKLKLMDGLSNSLSSSLGQPYQPCQYSGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2W8</accession>
    <name>H9G2W8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">unc-30</name>
        <name evidence="12" type="ORF">B0564.10</name>
        <name evidence="10" type="ORF">CELE_B0564.10</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255700.1">
        <property type="nucleotide sequence ID" value="NM_001268771.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2W8"/>
    <dbReference type="SMR" id="H9G2W8"/>
    <dbReference type="GeneID" id="178265"/>
    <dbReference type="AGR" id="WB:WBGene00006766"/>
    <dbReference type="CTD" id="178265"/>
    <dbReference type="WormBase" id="B0564.10c">
        <property type="protein sequence ID" value="CE47084"/>
        <property type="gene ID" value="WBGene00006766"/>
        <property type="gene designation" value="unc-30"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1490322_0_0_1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006766">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2W8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033563">
        <property type="term" value="P:dorsal/ventral axon guidance"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097154">
        <property type="term" value="P:GABAergic neuron differentiation"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="P:regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882:SF3">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCG28291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="B0564.10c"/>
        </source>
    </evidence>
    <sequence length="185" mass="20639" checksum="1644712C38F4B13B" modified="2012-05-16" version="1">MACREEIAVWISLTEPRVRVWFKNRRAKWRKRERNYVIDNGQGTTKVTAQSLDPLGSLQNTFPQTLLQSSSSQLDDSAVTSSSFYGYGGAWQQNPYYSRNNQTTFNWQIKPQDQFQFQTIPMSPTTATSRFSTAANLAPLPTAQAAFSTSATSSNDKLKLMDGLSNSLSSSLGQPYQPCQYSGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2W9</accession>
    <name>H9G2W9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_ZK822.9</name>
        <name evidence="1 3" type="ORF">ZK822.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255599.1">
        <property type="nucleotide sequence ID" value="NM_001268670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2W9"/>
    <dbReference type="SMR" id="H9G2W9"/>
    <dbReference type="GeneID" id="13198375"/>
    <dbReference type="AGR" id="WB:WBGene00219327"/>
    <dbReference type="CTD" id="13198375"/>
    <dbReference type="WormBase" id="ZK822.9a">
        <property type="protein sequence ID" value="CE47354"/>
        <property type="gene ID" value="WBGene00219327"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3377573_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00219327">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2W9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="ZK822.9a"/>
        </source>
    </evidence>
    <sequence length="34" mass="4246" checksum="72D762DDF74B7A75" modified="2012-05-16" version="1">MEKSDCVRNWKDRGKKRNEERIIEHIRGLFLFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2X0</accession>
    <name>H9G2X0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">kvs-2</name>
        <name evidence="17" type="ORF">C32C4.1</name>
        <name evidence="15" type="ORF">CELE_C32C4.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256238.1">
        <property type="nucleotide sequence ID" value="NM_001269309.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2X0"/>
    <dbReference type="SMR" id="H9G2X0"/>
    <dbReference type="GeneID" id="183120"/>
    <dbReference type="AGR" id="WB:WBGene00007862"/>
    <dbReference type="CTD" id="183120"/>
    <dbReference type="WormBase" id="C32C4.1i">
        <property type="protein sequence ID" value="CE47110"/>
        <property type="gene ID" value="WBGene00007862"/>
        <property type="gene designation" value="kvs-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007862">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2X0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000088">
        <property type="entry name" value="Protein CBG09661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000176">
        <property type="entry name" value="Protein CBG09661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF121">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="49"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCG28074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C32C4.1i"/>
        </source>
    </evidence>
    <sequence length="515" mass="58691" checksum="D6783EBA6CBEA70F" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2X2</accession>
    <name>H9G2X2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">lips-5</name>
        <name evidence="2" type="ORF">CELE_T12A7.4</name>
        <name evidence="4" type="ORF">T12A7.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255588.1">
        <property type="nucleotide sequence ID" value="NM_001268659.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2X2"/>
    <dbReference type="SMR" id="H9G2X2"/>
    <dbReference type="GeneID" id="188437"/>
    <dbReference type="AGR" id="WB:WBGene00011725"/>
    <dbReference type="CTD" id="188437"/>
    <dbReference type="WormBase" id="T12A7.4c">
        <property type="protein sequence ID" value="CE47365"/>
        <property type="gene ID" value="WBGene00011725"/>
        <property type="gene designation" value="lips-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5821855at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011725">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2X2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000191">
        <property type="entry name" value="LIPaSe related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF2">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003620731" evidence="1">
        <location>
            <begin position="17"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T12A7.4c"/>
        </source>
    </evidence>
    <sequence length="340" mass="37544" checksum="210445878E6459B7" modified="2012-05-16" version="1">MLLLVPSILLISTVLSQDIPEYGPISANFDAWLDRNGYGKYDYARLDLGTAGSFGGMSSDMEYFDTSKDPVIFFHGNSDAALTANNFSTGWTTTVQYFLNQGYTLGHLYGTSWGNTNTTAAVERDHDCVTVFRLRKFVEAVMDYTGAKQINIISHSMGVTLARKVILGGYINADDGSCNIGKPLGNKVRVILGIAGANFGLCACVGHWLGVTWPTCNDDNGLWPGETCYPNPMNGQCAASPLPSPCNGLTYSKFLMDLNNSRFKPAQHIFSMWSMEDELIDLRRMSRDDLIGDGNMVWGRPTSEIPFSDSNKIYKNYTHMETKLNTAADQFHIITQLTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2X3</accession>
    <name>H9G2X3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">pptr-2</name>
        <name evidence="12" type="ORF">C13G3.3</name>
        <name evidence="10" type="ORF">CELE_C13G3.3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256283.1">
        <property type="nucleotide sequence ID" value="NM_001269354.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2X3"/>
    <dbReference type="SMR" id="H9G2X3"/>
    <dbReference type="PeptideAtlas" id="H9G2X3"/>
    <dbReference type="GeneID" id="179526"/>
    <dbReference type="AGR" id="WB:WBGene00007554"/>
    <dbReference type="CTD" id="179526"/>
    <dbReference type="WormBase" id="C13G3.3d">
        <property type="protein sequence ID" value="CE47210"/>
        <property type="gene ID" value="WBGene00007554"/>
        <property type="gene designation" value="pptr-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007554">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2X3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010948">
        <property type="term" value="P:negative regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901990">
        <property type="term" value="P:regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCG28132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C13G3.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2X3"/>
        </source>
    </evidence>
    <sequence length="574" mass="66612" checksum="8A46C7986D8D7457" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2X4</accession>
    <name>H9G2X4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prion-like-(Q/N-rich)-domain-bearing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_D1054.9</name>
        <name evidence="3 5" type="ORF">D1054.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256252.1">
        <property type="nucleotide sequence ID" value="NM_001269323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2X4"/>
    <dbReference type="SMR" id="H9G2X4"/>
    <dbReference type="PeptideAtlas" id="H9G2X4"/>
    <dbReference type="GeneID" id="179495"/>
    <dbReference type="AGR" id="WB:WBGene00008376"/>
    <dbReference type="CTD" id="179495"/>
    <dbReference type="WormBase" id="D1054.9h">
        <property type="protein sequence ID" value="CE47342"/>
        <property type="gene ID" value="WBGene00008376"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846958at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008376">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2X4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0034">Amyloid</keyword>
    <keyword evidence="3" id="KW-0640">Prion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003619123" evidence="2">
        <location>
            <begin position="18"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="D1054.9h"/>
        </source>
    </evidence>
    <sequence length="518" mass="56597" checksum="45C59ECFABF34B0F" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2X5</accession>
    <name>H9G2X5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prion-like-(Q/N-rich)-domain-bearing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_D1054.9</name>
        <name evidence="3 5" type="ORF">D1054.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256254.1">
        <property type="nucleotide sequence ID" value="NM_001269325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2X5"/>
    <dbReference type="SMR" id="H9G2X5"/>
    <dbReference type="GeneID" id="179495"/>
    <dbReference type="AGR" id="WB:WBGene00008376"/>
    <dbReference type="CTD" id="179495"/>
    <dbReference type="WormBase" id="D1054.9g">
        <property type="protein sequence ID" value="CE47322"/>
        <property type="gene ID" value="WBGene00008376"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846958at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008376">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2X5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0034">Amyloid</keyword>
    <keyword evidence="3" id="KW-0640">Prion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003619618" evidence="2">
        <location>
            <begin position="18"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="D1054.9g"/>
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    <dbReference type="HOGENOM" id="CLU_819491_0_0_1"/>
    <dbReference type="OrthoDB" id="10061784at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009389">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2Y0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF4">
        <property type="entry name" value="BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CTCK" evidence="5">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCG28210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F35B12.10b"/>
        </source>
    </evidence>
    <sequence length="98" mass="10905" checksum="FDCB45DA10B2A2EA" modified="2012-05-16" version="1">MNQRCDGQKFKQRIRVDGCLTKVVVNRLCHGACASIFIPRMHSKKLKAAFRSCAACAPAEYDYVDITLDCPGRTPPTATKTIVKVKSCKCKEVRIAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2Y1</accession>
    <name>H9G2Y1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">cnb-1</name>
        <name evidence="6" type="ORF">CELE_F55C10.1</name>
        <name evidence="8" type="ORF">F55C10.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256317.1">
        <property type="nucleotide sequence ID" value="NM_001269388.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2Y1"/>
    <dbReference type="SMR" id="H9G2Y1"/>
    <dbReference type="PeptideAtlas" id="H9G2Y1"/>
    <dbReference type="GeneID" id="179572"/>
    <dbReference type="AGR" id="WB:WBGene00000554"/>
    <dbReference type="CTD" id="179572"/>
    <dbReference type="WormBase" id="F55C10.1b">
        <property type="protein sequence ID" value="CE47380"/>
        <property type="gene ID" value="WBGene00000554"/>
        <property type="gene designation" value="cnb-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000554">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2Y1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCG28054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F55C10.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2Y1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19434" checksum="78A155C90FBA682D" modified="2012-05-16" version="1">MGADASLPMEMCSNFDAYELRRLTRRFKKLDVDGSGSLSVEEFMSLPELQQNPLVQRVIDIFDEDGNGEVDFREFIQGISQFSVKGDKNTKLKFAFRIYDMDRDGFISNGELFQVLKMMVGNNLKDSQLQQIVDKTILFHDKDGDGKISFQEFCDVVGTLDIHEKMVVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2Y2</accession>
    <name>H9G2Y2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_T11F9.1</name>
        <name evidence="7 9" type="ORF">T11F9.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256325.1">
        <property type="nucleotide sequence ID" value="NM_001269396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2Y2"/>
    <dbReference type="SMR" id="H9G2Y2"/>
    <dbReference type="GeneID" id="188419"/>
    <dbReference type="AGR" id="WB:WBGene00011709"/>
    <dbReference type="CTD" id="188419"/>
    <dbReference type="WormBase" id="T11F9.1a">
        <property type="protein sequence ID" value="CE47396"/>
        <property type="gene ID" value="WBGene00011709"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039373_0_0_1"/>
    <dbReference type="OrthoDB" id="5783891at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011709">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2Y2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCG28068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="T11F9.1a"/>
        </source>
    </evidence>
    <sequence length="417" mass="48379" checksum="5E6F7680B7ABA176" modified="2012-05-16" version="1">MDYESTSFDQSIATNDTDQECAYSEPVYVKERFWMVAIFGTAVCIINILENTFLSFMLFKKKSYRSSHMLYLALLAFFDVWMALAYIPLMSLNLFVDYYKSVVLLRAWFAYMLPMITVSHIAMTASSFLMVAASLERYVITCHPTKNRWLSRNRMWIAAFAIFLGTTCKFSQLYEMEIEYLPQCMGTMREYQLNLSALARYEIYGYWRVHFRTIVTILIPFFSLAFINIRIVLVLSKNEFKFLHSTKLSDAKRKSAVRNATRTMVFIVFTYLLSNVLNVIIIIWEYIDMDMLTQQFETFYMFAVDVVSLSTIIFGALRLPIYVICQANLRKEFFAQLKTMLSLNSYTGFLSSSTKNMTIEDMDIDRRTPDISGDGTVLIVESDQKKDSSATCTVIRKNSLHRMNGGFSDMSEKVQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2Y4</accession>
    <name>H9G2Y4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Acetylcholine receptor DES-2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">des-2</name>
        <name evidence="18" type="ORF">CELE_T26H10.1</name>
        <name evidence="20" type="ORF">T26H10.1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380111.1">
        <property type="nucleotide sequence ID" value="NM_001392616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2Y4"/>
    <dbReference type="SMR" id="H9G2Y4"/>
    <dbReference type="PeptideAtlas" id="H9G2Y4"/>
    <dbReference type="GeneID" id="179574"/>
    <dbReference type="AGR" id="WB:WBGene00000955"/>
    <dbReference type="CTD" id="179574"/>
    <dbReference type="WormBase" id="T26H10.1b">
        <property type="protein sequence ID" value="CE47329"/>
        <property type="gene ID" value="WBGene00000955"/>
        <property type="gene designation" value="des-2"/>
    </dbReference>
    <dbReference type="OMA" id="KEHMMEA"/>
    <dbReference type="OrthoDB" id="410315at2759"/>
    <dbReference type="PhylomeDB" id="H9G2Y4"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000955">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2Y4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000049">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000031">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022269414" evidence="14">
        <location>
            <begin position="20"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="28"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="245"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCG28066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="T26H10.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2Y4"/>
        </source>
    </evidence>
    <sequence length="559" mass="63297" checksum="127FA3C876CA5783" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2Y5</accession>
    <name>H9G2Y5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">30S ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F56H9.2</name>
        <name evidence="1 3" type="ORF">F56H9.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256440.1">
        <property type="nucleotide sequence ID" value="NM_001269511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2Y5"/>
    <dbReference type="PeptideAtlas" id="H9G2Y5"/>
    <dbReference type="GeneID" id="179730"/>
    <dbReference type="AGR" id="WB:WBGene00010174"/>
    <dbReference type="CTD" id="179730"/>
    <dbReference type="WormBase" id="F56H9.2b">
        <property type="protein sequence ID" value="CE47264"/>
        <property type="gene ID" value="WBGene00010174"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2998420_0_0_1"/>
    <dbReference type="OrthoDB" id="5782731at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010174">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2Y5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F56H9.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2Y5"/>
        </source>
    </evidence>
    <sequence length="25" mass="2849" checksum="FAF5781E21289183" modified="2012-05-16" version="1">MYKRKISAVGIKDRGVRLEQFAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2Y7</accession>
    <name>H9G2Y7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Protein kinase C</fullName>
            <ecNumber evidence="2 15">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 26" type="primary">pkc-1</name>
        <name evidence="24" type="ORF">CELE_F57F5.5</name>
        <name evidence="26" type="ORF">F57F5.5</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2 15"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256396.1">
        <property type="nucleotide sequence ID" value="NM_001269467.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2Y7"/>
    <dbReference type="SMR" id="H9G2Y7"/>
    <dbReference type="PeptideAtlas" id="H9G2Y7"/>
    <dbReference type="GeneID" id="179649"/>
    <dbReference type="AGR" id="WB:WBGene00004032"/>
    <dbReference type="CTD" id="179649"/>
    <dbReference type="WormBase" id="F57F5.5c">
        <property type="protein sequence ID" value="CE47095"/>
        <property type="gene ID" value="WBGene00004032"/>
        <property type="gene designation" value="pkc-1"/>
    </dbReference>
    <dbReference type="OMA" id="MKIEICE"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="PhylomeDB" id="H9G2Y7"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004032">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2Y7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098981">
        <property type="term" value="C:cholinergic synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="SynGO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007611">
        <property type="term" value="P:learning or memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040012">
        <property type="term" value="P:regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099161">
        <property type="term" value="P:regulation of presynaptic dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="SynGO"/>
    </dbReference>
    <dbReference type="CDD" id="cd20835">
        <property type="entry name" value="C1_nPKC_epsilon-like_rpt1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C1_nPKC_epsilon-like_rpt2"/>
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        <property type="entry name" value="C2_PKC_epsilon"/>
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        <property type="entry name" value="STKc_nPKC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.60.20:FF:000063">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000003">
        <property type="entry name" value="Protein kinase C delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000126">
        <property type="entry name" value="Protein kinase C epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000508">
        <property type="entry name" value="Protein kinase C-like 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
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    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
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    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
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    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
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    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR034669">
        <property type="entry name" value="nPKC_epsilon"/>
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    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
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    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
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    <dbReference type="InterPro" id="IPR014376">
        <property type="entry name" value="Prot_kin_PKC_delta"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="PIRSF" id="PIRSF000551">
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        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
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    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="12 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 15 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="20">
        <location>
            <begin position="37"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="226"/>
            <end position="276"/>
        </location>
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        <location>
            <begin position="304"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="434"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="23">
        <location>
            <begin position="695"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="558"/>
        </location>
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    <feature type="binding site" evidence="17">
        <location>
            <begin position="440"/>
            <end position="448"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="17 18">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-51"/>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CCG28111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WormBase" id="F57F5.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="27">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2Y7"/>
        </source>
    </evidence>
    <sequence length="763" mass="86736" checksum="5A7E8A2BE5BC72ED" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2Y8</accession>
    <name>H9G2Y8_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cest-2.2</name>
        <name evidence="3" type="ORF">CELE_ZC376.2</name>
        <name evidence="5" type="ORF">ZC376.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256568.1">
        <property type="nucleotide sequence ID" value="NM_001269639.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2Y8"/>
    <dbReference type="SMR" id="H9G2Y8"/>
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        <property type="family name" value="Carb_B_Nematoda"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="H9G2Y8"/>
    <dbReference type="GeneID" id="179917"/>
    <dbReference type="AGR" id="WB:WBGene00013874"/>
    <dbReference type="CTD" id="179917"/>
    <dbReference type="WormBase" id="ZC376.2c">
        <property type="protein sequence ID" value="CE47318"/>
        <property type="gene ID" value="WBGene00013874"/>
        <property type="gene designation" value="cest-2.2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1455639_0_0_1"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013874">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2Y8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003620141" evidence="1">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="ZC376.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2Y8"/>
        </source>
    </evidence>
    <sequence length="204" mass="22912" checksum="8433C20DBBE46AC3" modified="2012-05-16" version="1">MFFRFFILWAILQNVRSTKVKLSTGTIEGRTLTASYSPLGNQTGIVFFGVPYVEPPVGNLRFRKPRPPKPWDGVLEAKEYKAACMSDQKKTYKNGVGGPVSEDCLYANVFTNQYCLEHKNCSVMLTIHGGRFVIESASAYDPEIIINNFVGQGRNIVVVTFNYRLGLFGLGMLNGDNQDTNFGLYGLCVNFGSFFRKRNSFKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2Z0</accession>
    <name>H9G2Z0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">cal-1</name>
        <name evidence="6" type="ORF">C13C12.1</name>
        <name evidence="4" type="ORF">CELE_C13C12.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256428.1">
        <property type="nucleotide sequence ID" value="NM_001269499.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2Z0"/>
    <dbReference type="SMR" id="H9G2Z0"/>
    <dbReference type="GeneID" id="179715"/>
    <dbReference type="AGR" id="WB:WBGene00000285"/>
    <dbReference type="CTD" id="179715"/>
    <dbReference type="WormBase" id="C13C12.1b">
        <property type="protein sequence ID" value="CE47386"/>
        <property type="gene ID" value="WBGene00000285"/>
        <property type="gene designation" value="cal-1"/>
    </dbReference>
    <dbReference type="OMA" id="EFRYFMI"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="H9G2Z0"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000285">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2Z0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000238">
        <property type="entry name" value="CALmodulin related genes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000337">
        <property type="entry name" value="CALmodulin related genes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCG28245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C13C12.1b"/>
        </source>
    </evidence>
    <sequence length="180" mass="21002" checksum="3AC51DF10BD20B33" modified="2012-05-16" version="1">MVRFFSSRLARDMAIRAERMAIPSNLMQFSEDIIKQLTPEEIDEFREAFMMFDKDGNGTISTKELGIAMRSLGQNPTEQEILEMINEVDIDGNGQIEFPEFCVMMKRMMKETDSEMIREAFRVFDKDGNGVITAQEFRYFMVHMGMQFSEEEVDEMIKEVDVDGDGEIDYEEFVKMMSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2Z1</accession>
    <name>H9G2Z1_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CELE_M04B2.7</name>
        <name evidence="3 5" type="ORF">M04B2.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255563.1">
        <property type="nucleotide sequence ID" value="NM_001268634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2Z1"/>
    <dbReference type="GeneID" id="3565562"/>
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    <dbReference type="CTD" id="3565562"/>
    <dbReference type="WormBase" id="M04B2.7f">
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        <property type="gene ID" value="WBGene00010849"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115550_0_0_1"/>
    <dbReference type="OrthoDB" id="5788478at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010849">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="M04B2.7f"/>
        </source>
    </evidence>
    <sequence length="206" mass="23429" checksum="5523D73B12293AA7" modified="2012-05-16" version="1">MKVNGQPEEGDEPTVSSLLSSSNSTSHHSNSTNRRITLMDFFDVRKFQSSHRDFVVNDGRLHVVSDYSLIALLPVILVGLLITTIFCVYRFRRWKHNKKQLAELNAFYEIVESSPCLASGKPYLIQHCKDVEKSECDRITRAVCVPTQSSIFFQPIPPKAKSVRCNSDVLKAVNASEVLFHFAQLPTIEKINNNNNKKSLHFIHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2Z2</accession>
    <name>H9G2Z2_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_M04B2.7</name>
        <name evidence="3 5" type="ORF">M04B2.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255562.1">
        <property type="nucleotide sequence ID" value="NM_001268633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2Z2"/>
    <dbReference type="GeneID" id="3565562"/>
    <dbReference type="KEGG" id="cel:CELE_M04B2.7"/>
    <dbReference type="AGR" id="WB:WBGene00010849"/>
    <dbReference type="CTD" id="3565562"/>
    <dbReference type="WormBase" id="M04B2.7d">
        <property type="protein sequence ID" value="CE47409"/>
        <property type="gene ID" value="WBGene00010849"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5788478at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010849">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2Z2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="M04B2.7d"/>
        </source>
    </evidence>
    <sequence length="212" mass="24043" checksum="53049F12DDF2EBF1" modified="2012-05-16" version="1">MVTSKVVKVNGQPEEGDEPTVSSLLSSSNSTSHHSNSTNRRITLMDFFDVRKFQSSHRDFVVNDGRLHVVSDYSLIALLPVILVGLLITTIFCVYRFRRWKHNKKQLAELNAFYEIVESSPCLASGKPYLIQHCKDVEKSECDRITRAVCVPTQSSIFFQPIPPKAKSVRCNSDVLKAVNASEVLFHFAQLPTIEKINNNNNKKSLHFIHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H9G2Z7</accession>
    <name>H9G2Z7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BESS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C30H6.12</name>
        <name evidence="2" type="ORF">CELE_C30H6.12</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255952.1">
        <property type="nucleotide sequence ID" value="NM_001269023.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9G2Z7"/>
    <dbReference type="GeneID" id="3565196"/>
    <dbReference type="AGR" id="WB:WBGene00044238"/>
    <dbReference type="CTD" id="3565196"/>
    <dbReference type="WormBase" id="C30H6.12b">
        <property type="protein sequence ID" value="CE41361"/>
        <property type="gene ID" value="WBGene00044238"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1645306_0_0_1"/>
    <dbReference type="OrthoDB" id="5867728at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044238">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H9G2Z7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C30H6.12b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H9G2Z7"/>
        </source>
    </evidence>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">Bristol N2</strain>
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    </dbReference>
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        <property type="entry name" value="BPI/LBP/Plunc"/>
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        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
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            <begin position="310"/>
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        </location>
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        <location>
            <begin position="421"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="354"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00329"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCG28162.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F10D11.6b"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="H9G2Z9"/>
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    </evidence>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="J. Biol. Chem." volume="285" first="29319" last="29325">
            <title>Contribution of the peroxisomal acox gene to the dynamic balance of daumone production in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Joo H.J."/>
                <person name="Kim K.Y."/>
                <person name="Yim Y.H."/>
                <person name="Jin Y.X."/>
                <person name="Kim H."/>
                <person name="Kim M.Y."/>
                <person name="Paik Y.K."/>
            </authorList>
            <dbReference type="PubMed" id="20610393"/>
            <dbReference type="DOI" id="10.1074/jbc.m110.122663"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2015" name="Proc. Natl. Acad. Sci. U.S.A." volume="112" first="3955" last="3960">
            <title>Acyl-CoA oxidase complexes control the chemical message produced by Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Feng L."/>
                <person name="Chinta S."/>
                <person name="Singh P."/>
                <person name="Wang Y."/>
                <person name="Nunnery J.K."/>
                <person name="Butcher R.A."/>
            </authorList>
            <dbReference type="PubMed" id="25775534"/>
            <dbReference type="DOI" id="10.1073/pnas.1423951112"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>PATHWAY</scope>
        <scope>SUBUNIT</scope>
        <scope>INTERACTION WITH ACOX-1.2 AND ACOX-1.3</scope>
    </reference>
    <reference evidence="9 10 11" key="4">
        <citation type="journal article" date="2016" name="Proc. Natl. Acad. Sci. U.S.A." volume="113" first="10055" last="10060">
            <title>Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Li K."/>
                <person name="Jones R.A."/>
                <person name="Bruner S.D."/>
                <person name="Butcher R.A."/>
            </authorList>
            <dbReference type="PubMed" id="27551084"/>
            <dbReference type="DOI" id="10.1073/pnas.1608262113"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.48 ANGSTROMS) OF APO FORM AND MUTANT ALA-434 IN COMPLEX WITH ATP AND FAD</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>PATHWAY</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF VAL-118; TRP-189; TYR-245; GLY-301; GLN-340; LYS-391; HIS-396; GLU-434; ASN-437; ARG-533 AND ARG-536</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2018" name="ACS Chem. Biol." volume="13" first="1048" last="1056">
            <title>Acyl-CoA Oxidases Fine-Tune the Production of Ascaroside Pheromones with Specific Side Chain Lengths.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Wang Y."/>
                <person name="Perez D.H."/>
                <person name="Jones Lipinski R.A."/>
                <person name="Butcher R.A."/>
            </authorList>
            <dbReference type="PubMed" id="29537254"/>
            <dbReference type="DOI" id="10.1021/acschembio.7b01021"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF HIS-396 AND GLU-434</scope>
    </reference>
    <reference evidence="4" key="6">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans.</title>
            <authorList>
                <person name="Zhou Y."/>
                <person name="Wang Y."/>
                <person name="Zhang X."/>
                <person name="Bhar S."/>
                <person name="Jones Lipinski R.A."/>
                <person name="Han J."/>
                <person name="Feng L."/>
                <person name="Butcher R.A."/>
            </authorList>
            <dbReference type="PubMed" id="29863473"/>
            <dbReference type="DOI" id="10.7554/elife.33286"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF GLU-434</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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            <id>O62140-1</id>
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        <source>
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    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="27551084"/>
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    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F08A8.1b"/>
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    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="F08A8.1c"/>
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    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="5K3G"/>
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    </evidence>
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        <source>
            <dbReference type="PDB" id="5K3H"/>
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        <source>
            <dbReference type="PDB" id="5K3I"/>
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    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2021-04-07" modified="2026-01-28" version="169" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="J. Biol. Chem." volume="285" first="29319" last="29325">
            <title>Contribution of the peroxisomal acox gene to the dynamic balance of daumone production in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Joo H.J."/>
                <person name="Kim K.Y."/>
                <person name="Yim Y.H."/>
                <person name="Jin Y.X."/>
                <person name="Kim H."/>
                <person name="Kim M.Y."/>
                <person name="Paik Y.K."/>
            </authorList>
            <dbReference type="PubMed" id="20610393"/>
            <dbReference type="DOI" id="10.1074/jbc.m110.122663"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2015" name="Proc. Natl. Acad. Sci. U.S.A." volume="112" first="3955" last="3960">
            <title>Acyl-CoA oxidase complexes control the chemical message produced by Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Feng L."/>
                <person name="Chinta S."/>
                <person name="Singh P."/>
                <person name="Wang Y."/>
                <person name="Nunnery J.K."/>
                <person name="Butcher R.A."/>
            </authorList>
            <dbReference type="PubMed" id="25775534"/>
            <dbReference type="DOI" id="10.1073/pnas.1423951112"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>PATHWAY</scope>
        <scope>SUBUNIT</scope>
        <scope>INTERACTION WITH ACOX-1.2 AND ACOX-1.3</scope>
    </reference>
    <reference evidence="9 10 11" key="4">
        <citation type="journal article" date="2016" name="Proc. Natl. Acad. Sci. U.S.A." volume="113" first="10055" last="10060">
            <title>Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Li K."/>
                <person name="Jones R.A."/>
                <person name="Bruner S.D."/>
                <person name="Butcher R.A."/>
            </authorList>
            <dbReference type="PubMed" id="27551084"/>
            <dbReference type="DOI" id="10.1073/pnas.1608262113"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.48 ANGSTROMS) OF APO FORM AND MUTANT ALA-434 IN COMPLEX WITH ATP AND FAD</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>PATHWAY</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF VAL-118; TRP-189; TYR-245; GLY-301; GLN-340; LYS-391; HIS-396; GLU-434; ASN-437; ARG-533 AND ARG-536</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2018" name="ACS Chem. Biol." volume="13" first="1048" last="1056">
            <title>Acyl-CoA Oxidases Fine-Tune the Production of Ascaroside Pheromones with Specific Side Chain Lengths.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Wang Y."/>
                <person name="Perez D.H."/>
                <person name="Jones Lipinski R.A."/>
                <person name="Butcher R.A."/>
            </authorList>
            <dbReference type="PubMed" id="29537254"/>
            <dbReference type="DOI" id="10.1021/acschembio.7b01021"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF HIS-396 AND GLU-434</scope>
    </reference>
    <reference evidence="4" key="6">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans.</title>
            <authorList>
                <person name="Zhou Y."/>
                <person name="Wang Y."/>
                <person name="Zhang X."/>
                <person name="Bhar S."/>
                <person name="Jones Lipinski R.A."/>
                <person name="Han J."/>
                <person name="Feng L."/>
                <person name="Butcher R.A."/>
            </authorList>
            <dbReference type="PubMed" id="29863473"/>
            <dbReference type="DOI" id="10.7554/elife.33286"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF GLU-434</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O62140-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_060949"/>
        </isoform>
        <isoform>
            <id>O62140-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_060950"/>
        </isoform>
        <isoform>
            <id>O62140-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="1.3.3.-" evidence="1 2 3"/>
    <dbReference type="EC" id="1.3.3.6" evidence="1 2 3"/>
    <dbReference type="RefSeq" id="NP_001040649.1">
        <property type="nucleotide sequence ID" value="NM_001047184.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F08A8.1c">
        <property type="protein sequence ID" value="CE39570"/>
        <property type="gene ID" value="WBGene00008564"/>
        <property type="gene designation" value="acox-1.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="25775534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="27551084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="29537254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F08A8.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F08A8.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="F08A8.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="5K3G"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="5K3H"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="11">
        <source>
            <dbReference type="PDB" id="5K3I"/>
        </source>
    </evidence>
    <sequence length="645" mass="72853" checksum="A738A99769B8B5E6" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>P30647-2</accession>
    <name>ARD15_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Arrestin domain-containing protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">arrd-15</name>
        <name type="ORF">ZK643.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Nature" volume="356" first="37" last="41">
            <title>The C. elegans genome sequencing project: a beginning.</title>
            <authorList>
                <person name="Sulston J."/>
                <person name="Du Z."/>
                <person name="Thomas K."/>
                <person name="Wilson R."/>
                <person name="Hillier L."/>
                <person name="Staden R."/>
                <person name="Halloran N."/>
                <person name="Green P."/>
                <person name="Thierry-Mieg J."/>
                <person name="Qiu L."/>
                <person name="Dear S."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Durbin R."/>
                <person name="Berks M."/>
                <person name="Metzstein M."/>
                <person name="Hawkins T."/>
                <person name="Ainscough R."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="1538779"/>
            <dbReference type="DOI" id="10.1038/356037a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P30647-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_039806"/>
        </isoform>
        <isoform>
            <id>P30647-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001254971.1">
        <property type="nucleotide sequence ID" value="NM_001268042.3"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK643.1b">
        <property type="protein sequence ID" value="CE44174"/>
        <property type="gene ID" value="WBGene00014033"/>
        <property type="gene designation" value="arrd-15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="342" mass="38605" checksum="1CE6E0FCAB2EEEAA" modified="2010-10-05" version="2">MPTTQINIVLAEPRCMAGEFFNAKVLLDSSDPDTVVHSFCAEIKGIGRTGWVNIHTDKIFETEKTYIDTQVQLCDSGTCLPVGKHQFPVQIRIPLNCPSSYESQFGSIRYQMKVELRASTDQASCSEVFPLVILTRSFFDDVPLNAMSPIDFKDEVDFTCCTLPFGCVSLNMSLTRTAFRIGESIEAVVTINNRTRKGLKEVALQLIMKTQFEARSRYEHVNEKKLAEQLIEMVPLGAVKSRCRMEFEKCLLRIPDAAPPTQNYNRGAGESSIIAIHYVLKLTALPGIECEIPLIVTSCGYMDPHKQAAFQHHLNRSKAKVSKTEQQQRKTRNIVEENPYFR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>P41936-2</accession>
    <name>HM22_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Homeobox protein ceh-22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ceh-22</name>
        <name type="ORF">F29F11.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Development" volume="120" first="2175" last="2186">
            <title>The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle.</title>
            <authorList>
                <person name="Okkema P.G."/>
                <person name="Fire A."/>
            </authorList>
            <dbReference type="PubMed" id="7925019"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="Development" volume="141" first="209" last="218">
            <title>HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans.</title>
            <authorList>
                <person name="Shibata Y."/>
                <person name="Sawa H."/>
                <person name="Nishiwaki K."/>
            </authorList>
            <dbReference type="PubMed" id="24346701"/>
            <dbReference type="DOI" id="10.1242/dev.090746"/>
        </citation>
        <scope>FUNCTION (ISOFORM B)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Regulates distal tip cell fate.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P41936-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_057962"/>
        </isoform>
        <isoform>
            <id>P41936-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_057963"/>
        </isoform>
        <isoform>
            <id>P41936-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001076744.1">
        <property type="nucleotide sequence ID" value="NM_001083275.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F29F11.5c">
        <property type="protein sequence ID" value="CE40612"/>
        <property type="gene ID" value="WBGene00000445"/>
        <property type="gene designation" value="ceh-22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="24346701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F29F11.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F29F11.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F29F11.5c"/>
        </source>
    </evidence>
    <sequence length="283" mass="31641" checksum="2FBD8B699D98AEFC" modified="1995-11-01" version="1">MQTYAFSRLEAKWDTLLPTDTNLQCSTWPDSIPLLAGYSATPTFSFDPCTYGSYDPSAYFASNGIAGSMYTLPDQFPRSENDMLDNSNTSNGNKSDKDGIKLEDEDEILEDEENDEEDDGTGKRKKRKRRVLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTDKPINAALLTTMPNAFSSQSTAASFPTRAMPIPMLVRDSSARSSDISSTSPYTVAFGSANSGYLPTPSAYLPATSGYFSNGPSAASSYMTNTQWWPS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>P41936-3</accession>
    <name>HM22_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Homeobox protein ceh-22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ceh-22</name>
        <name type="ORF">F29F11.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Development" volume="120" first="2175" last="2186">
            <title>The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle.</title>
            <authorList>
                <person name="Okkema P.G."/>
                <person name="Fire A."/>
            </authorList>
            <dbReference type="PubMed" id="7925019"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="Development" volume="141" first="209" last="218">
            <title>HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans.</title>
            <authorList>
                <person name="Shibata Y."/>
                <person name="Sawa H."/>
                <person name="Nishiwaki K."/>
            </authorList>
            <dbReference type="PubMed" id="24346701"/>
            <dbReference type="DOI" id="10.1242/dev.090746"/>
        </citation>
        <scope>FUNCTION (ISOFORM B)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P41936-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P41936-3</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_057962"/>
        </isoform>
        <isoform>
            <id>P41936-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_057963"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001076743.1">
        <property type="nucleotide sequence ID" value="NM_001083274.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F29F11.5b">
        <property type="protein sequence ID" value="CE40611"/>
        <property type="gene ID" value="WBGene00000445"/>
        <property type="gene designation" value="ceh-22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="F29F11.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F29F11.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F29F11.5c"/>
        </source>
    </evidence>
    <sequence length="215" mass="24247" checksum="2D86D5B60ECAFEF4" modified="1995-11-01" version="1">MYTLPDQFPRSENDMLDNSNTSNGNKSDKDGIKLEDEDEILEDEENDEEDDGTGKRKKRKRRVLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTDKPINAALLTTMPNAFSSQSTAASFPTRAMPIPMLVRDSSARSSDISSTSPYTVAFGSANSGYLPTPSAYLPATSGYFSNGPSAASSYMTNTQWWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-05-01" modified="2026-01-28" version="181" xmlns="https://uniprot.org/uniprot">
    <accession>P91502</accession>
    <name>P91502_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 16">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 16">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">usp-5</name>
        <name evidence="20" type="ORF">CELE_T27A3.2</name>
        <name evidence="22" type="ORF">T27A3.2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 24 25">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 16">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 16"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD72002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T25921">
        <property type="entry name" value="T25921"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491765.2">
        <property type="nucleotide sequence ID" value="NM_059364.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P91502"/>
    <dbReference type="SMR" id="P91502"/>
    <dbReference type="STRING" id="6239.T27A3.2.1"/>
    <dbReference type="MEROPS" id="C19.A41"/>
    <dbReference type="PaxDb" id="6239-T27A3.2"/>
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</entry>
<entry dataset="Swiss-Prot" created="2022-08-03" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q0G825-2</accession>
    <name>PSAP3_CAEEL</name>
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        <recommendedName>
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        </alternativeName>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2006" name="Dev. Cell" volume="11" first="105" last="115">
            <title>Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans.</title>
            <authorList>
                <person name="Arata Y."/>
                <person name="Kouike H."/>
                <person name="Zhang Y."/>
                <person name="Herman M.A."/>
                <person name="Okano H."/>
                <person name="Sawa H."/>
            </authorList>
            <dbReference type="PubMed" id="16824957"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2006.04.020"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CEH-20</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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            <id>Q0G825-1</id>
            <name evidence="4">a</name>
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        </isoform>
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            <sequence type="described" ref="VSP_061534"/>
        </isoform>
        <isoform>
            <id>Q0G825-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_061533"/>
        </isoform>
    </comment>
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        <property type="gene ID" value="WBGene00009560"/>
        <property type="gene designation" value="psa-3"/>
    </dbReference>
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        <property type="component" value="Chromosome X"/>
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            <dbReference type="EMBL" id="AAZ23152.1"/>
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    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F39D8.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F39D8.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F39D8.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F39D8.2d"/>
        </source>
    </evidence>
    <sequence length="241" mass="26710" checksum="B6579A07BEA402B5" modified="2015-11-11" version="2">MSPNIKGISPTATNIKSPKKSALFEKIASHPLMPIVELLLEKCETAATTFDRKAFETDDIKRLFQSLEQRGVQLSSNRDEVDELMETAILALRTCMVELERVYSLMESFKAKYLATLRRTVCHEALVGNNGDSDDELSDNPLMPVLEMSEAAFQAQNKAMESALATLQSVSGSLSLPLQFTHQSITAAQIERNLEFLKQCGFPTQLPPNFLKPSNEKSPEKSEEEKSQKPSSSPKSPSLSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-08-03" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q0G825-3</accession>
    <name>PSAP3_CAEEL</name>
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        <recommendedName>
            <fullName evidence="1">Isoform c of Transcriptional coregulator psa-3</fullName>
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        <alternativeName>
            <fullName evidence="4">Phasmid socket absent protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">psa-3</name>
        <name evidence="4" type="ORF">F39D8.2</name>
    </gene>
    <organism>
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        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2006" name="Dev. Cell" volume="11" first="105" last="115">
            <title>Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans.</title>
            <authorList>
                <person name="Arata Y."/>
                <person name="Kouike H."/>
                <person name="Zhang Y."/>
                <person name="Herman M.A."/>
                <person name="Okano H."/>
                <person name="Sawa H."/>
            </authorList>
            <dbReference type="PubMed" id="16824957"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2006.04.020"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CEH-20</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q0G825-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_061534"/>
        </isoform>
        <isoform>
            <id>Q0G825-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q0G825-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061535"/>
        </isoform>
        <isoform>
            <id>Q0G825-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_061533"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001257263.1">
        <property type="nucleotide sequence ID" value="NM_001270334.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F39D8.2c">
        <property type="protein sequence ID" value="CE34185"/>
        <property type="gene ID" value="WBGene00009560"/>
        <property type="gene designation" value="psa-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAZ23152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F39D8.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F39D8.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F39D8.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F39D8.2d"/>
        </source>
    </evidence>
    <sequence length="209" mass="23321" checksum="3F29F7E14BEDDD0F" modified="2015-11-11" version="2">MPIVELLLEKCETAATTFDRKAFETDDIKRLFQSLEQRGVQLSSNRDEVDELMETAILALRTCMVELERVYSLMESFKAKYLATLRRTVCHEALVGNNGDSDDELSDNPLMPVLEMSEAAFQAQNKAMESALATLQSVSGSLSLPLQFTHQSITAAQIERNLEFLKQCGFPTQLPPNFLKPSNEKSPEKSEEEKSQKPSSSPKSPSLSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-08-03" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q0G825-4</accession>
    <name>PSAP3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of Transcriptional coregulator psa-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Phasmid socket absent protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">psa-3</name>
        <name evidence="4" type="ORF">F39D8.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2006" name="Dev. Cell" volume="11" first="105" last="115">
            <title>Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans.</title>
            <authorList>
                <person name="Arata Y."/>
                <person name="Kouike H."/>
                <person name="Zhang Y."/>
                <person name="Herman M.A."/>
                <person name="Okano H."/>
                <person name="Sawa H."/>
            </authorList>
            <dbReference type="PubMed" id="16824957"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2006.04.020"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CEH-20</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q0G825-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_061534"/>
        </isoform>
        <isoform>
            <id>Q0G825-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061535"/>
        </isoform>
        <isoform>
            <id>Q0G825-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q0G825-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_061533"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001300347.1">
        <property type="nucleotide sequence ID" value="NM_001313418.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F39D8.2d">
        <property type="protein sequence ID" value="CE50444"/>
        <property type="gene ID" value="WBGene00009560"/>
        <property type="gene designation" value="psa-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAZ23152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F39D8.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F39D8.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F39D8.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F39D8.2d"/>
        </source>
    </evidence>
    <sequence length="157" mass="17310" checksum="5F93E6724FCDFD7B" modified="2015-11-11" version="2">METAILALRTCMVELERVYSLMESFKAKYLATLRRTVCHEALVGNNGDSDDELSDNPLMPVLEMSEAAFQAQNKAMESALATLQSVSGSLSLPLQFTHQSITAAQIERNLEFLKQCGFPTQLPPNFLKPSNEKSPEKSEEEKSQKPSSSPKSPSLSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-10-16" modified="2026-01-28" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q22397-2</accession>
    <name>AAT6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform b of Amino acid transporter protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aat-6</name>
        <name evidence="3" type="ORF">T11F9.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E43050" last="E43050">
            <title>NRFL-1, the C. elegans NHERF orthologue, interacts with amino acid transporter 6 (AAT-6) for age-dependent maintenance of AAT-6 on the membrane.</title>
            <authorList>
                <person name="Hagiwara K."/>
                <person name="Nagamori S."/>
                <person name="Umemura Y.M."/>
                <person name="Ohgaki R."/>
                <person name="Tanaka H."/>
                <person name="Murata D."/>
                <person name="Nakagomi S."/>
                <person name="Nomura K.H."/>
                <person name="Kage-Nakadai E."/>
                <person name="Mitani S."/>
                <person name="Nomura K."/>
                <person name="Kanai Y."/>
            </authorList>
            <dbReference type="PubMed" id="22916205"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0043050"/>
        </citation>
        <scope>INTERACTION WITH NRFL-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF 521-THR--MET-523</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2018" name="Front. Mol. Biosci." volume="5" first="109" last="109">
            <title>The Reproduction Rate of Peptide Transporter PEPT-1 Deficient C. elegans Is Dependent on Dietary Glutamate Supply.</title>
            <authorList>
                <person name="Spanier B."/>
                <person name="Wallwitz J."/>
                <person name="Zapoglou D."/>
                <person name="Idrissou B.M.G."/>
                <person name="Fischer C."/>
                <person name="Troll M."/>
                <person name="Petzold K."/>
                <person name="Daniel H."/>
            </authorList>
            <dbReference type="PubMed" id="30560135"/>
            <dbReference type="DOI" id="10.3389/fmolb.2018.00109"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q22397-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q22397-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060386"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001123014.1">
        <property type="nucleotide sequence ID" value="NM_001129542.4"/>
    </dbReference>
    <dbReference type="WormBase" id="T11F9.4b">
        <property type="protein sequence ID" value="CE42501"/>
        <property type="gene ID" value="WBGene00000007"/>
        <property type="gene designation" value="aat-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T11F9.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T11F9.4b"/>
        </source>
    </evidence>
    <sequence length="513" mass="56363" checksum="667AFE48473FA42E" modified="2003-03-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-04-04" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2A7S9</accession>
    <name>Q2A7S9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UNC93-like protein MFSD11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_Y11D7A.3</name>
        <name evidence="7 9" type="ORF">Y11D7A.3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ80824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041018.1">
        <property type="nucleotide sequence ID" value="NM_001047553.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2A7S9"/>
    <dbReference type="PeptideAtlas" id="Q2A7S9"/>
    <dbReference type="GeneID" id="177745"/>
    <dbReference type="UCSC" id="Y11D7A.3b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012428"/>
    <dbReference type="CTD" id="177745"/>
    <dbReference type="WormBase" id="Y11D7A.3b">
        <property type="protein sequence ID" value="CE39969"/>
        <property type="gene ID" value="WBGene00012428"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5778776at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012428">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2A7S9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF21">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ80824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y11D7A.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q2A7S9"/>
        </source>
    </evidence>
    <sequence length="462" mass="51601" checksum="2AB225ABDDB646BF" modified="2006-04-04" version="1">MAWIHRFWMELTPRRHELLSTYLLGIGTLFLYTGYSLQQFIGESVIHSIHEKSPDTISAYAGYYGAAFHLSAFAVFSLITPSLQHFVPSKWFLTLASALFAVYYLGFFQLNKYYFYLTQALMGVGYSFYNNGEGQYLSEHSSRRTIESNTGIETAVGHASMFFGGIALIVLCFLLHTDGGTGIEYSDLQIRFIYGTMFILNIFSVIVFAFLPTKQYDSIASKSSTVVPSFANQIKQLLKAFQSTNLLILMPFFFFQGFAVSFLMTVYPTTLSFTHAFKTDIYIIGIYSVSMGLAEAIGGIFLRPLLKRAGDYGLYVTAGFNFLSYSVVIILAFLSIPNLSTFGPTSSPPIFLTPSRLLVFIIGFLIGFSDFCVTMARAVICQVAVPDCRMQVFSLSKLYQSGSSVVVLLLTPYMTIYIWLCVLTIFLLIGTTCFVIVARRTAADRQKHSIAHPSQAQLADKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-01-10" modified="2025-10-08" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q2V4S5</accession>
    <name>Q2V4S5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">npr-16</name>
        <name evidence="12" type="ORF">CELE_F56B6.5</name>
        <name evidence="14" type="ORF">F56B6.5</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD64322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041259.1">
        <property type="nucleotide sequence ID" value="NM_001047794.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2V4S5"/>
    <dbReference type="SMR" id="Q2V4S5"/>
    <dbReference type="GeneID" id="180643"/>
    <dbReference type="UCSC" id="F56B6.5b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006864"/>
    <dbReference type="CTD" id="180643"/>
    <dbReference type="WormBase" id="F56B6.5b">
        <property type="protein sequence ID" value="CE39375"/>
        <property type="gene ID" value="WBGene00006864"/>
        <property type="gene designation" value="npr-16"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645979_0_0_1"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006864">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2V4S5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000440">
        <property type="entry name" value="NeuroPeptide Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF50">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="25"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD64322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F56B6.5b"/>
        </source>
    </evidence>
    <sequence length="420" mass="48129" checksum="C9B9FDE252BB23E5" modified="2006-01-10" version="1">MSDSSQHLRLALTVTHLLLVALGSVNLIIILLIITRPYLRSITNVYMIGLCLADFIYLADLILVAATSLNGKSWPFGPTICHLFHGTEATGKYASVLFVVLLAADRYIAMCKSDLCGRYRTYRTAIFLSGLAWIAAFICSLPLYVYADEIKVRMRPKNGTDSIENNHTLCIAHWPSPPHAQWYISVCSVMIFILPGLVIFYCYYHVFCKLREAAKGSRRLHRNKRSRSSYQRVTRSVQRVVLFHLLCWSPFWLFNLFSAIFRVRITTQLMRIIVNIIHLFPYVNCALNPVLYAYRAENFRTAFKSLLFWSRRNRPLPLPEDVRSTSASTYYRNSSNLDCLKSSLPIKSTMEPASVYQPEEESPVDSTENLEMERKKAELQAWRPYDGTNCEVLEVQYDHHKCSARSILLPAVTVDEGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-01-10" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q2V4T0</accession>
    <name>Q2V4T0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_T19D12.4</name>
        <name evidence="3 5" type="ORF">T19D12.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD71843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2V4T0"/>
    <dbReference type="SMR" id="Q2V4T0"/>
    <dbReference type="PeptideAtlas" id="Q2V4T0"/>
    <dbReference type="UCSC" id="T19D12.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020579"/>
    <dbReference type="WormBase" id="T19D12.4b">
        <property type="protein sequence ID" value="CE39409"/>
        <property type="gene ID" value="WBGene00020579"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_294780_0_0_1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020579">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2V4T0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052229">
        <property type="entry name" value="Collagen-VI/PIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588:SF19">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="376"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD71843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T19D12.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q2V4T0"/>
        </source>
    </evidence>
    <sequence length="1015" mass="111304" checksum="24F1F1F5E25B91A7" modified="2006-01-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-01-10" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q2V4T1</accession>
    <name>Q2V4T1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PARP catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_ZK813.4</name>
        <name evidence="1 3" type="ORF">ZK813.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041305.1">
        <property type="nucleotide sequence ID" value="NM_001047840.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2V4T1"/>
    <dbReference type="SMR" id="Q2V4T1"/>
    <dbReference type="GeneID" id="180633"/>
    <dbReference type="UCSC" id="ZK813.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022823"/>
    <dbReference type="CTD" id="180633"/>
    <dbReference type="WormBase" id="ZK813.4b">
        <property type="protein sequence ID" value="CE39463"/>
        <property type="gene ID" value="WBGene00022823"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1723925_0_0_1"/>
    <dbReference type="OrthoDB" id="5869600at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022823">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2V4T1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD63037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="ZK813.4b"/>
        </source>
    </evidence>
    <sequence length="152" mass="17280" checksum="7A645A78ADC4AAF6" modified="2006-01-10" version="1">MGCVFGRHCDPGVPDSSVRYRWHVDAFILDDGTNSEIRRGGIVYVADEAIVYRPRRFDCSKRGGSYTAEILNVQKTSKGKTYTPDNHRTIKRNIIWIEVMEGDIAQTLGLVTVGDVHKIYDDICDIINKHRERPKIVQYNSIDIDGVEIDPV</sequence>
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    <accession>Q86MD3-2</accession>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2010" name="PLoS Genet." volume="6" first="e1000892" last="e1000892">
            <title>Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shivers R.P."/>
                <person name="Pagano D.J."/>
                <person name="Kooistra T."/>
                <person name="Richardson C.E."/>
                <person name="Reddy K.C."/>
                <person name="Whitney J.K."/>
                <person name="Kamanzi O."/>
                <person name="Matsumoto K."/>
                <person name="Hisamoto N."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="20369020"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000892"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PMK-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-107</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="e1003324" last="e1003324">
            <title>RFX transcription factor DAF-19 regulates 5-HT and innate immune responses to pathogenic bacteria in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Xie Y."/>
                <person name="Moussaif M."/>
                <person name="Choi S."/>
                <person name="Xu L."/>
                <person name="Sze J.Y."/>
            </authorList>
            <dbReference type="PubMed" id="23505381"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003324"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005265" last="E1005265">
            <title>The developmental intestinal regulator ELT-2 controls p38-dependent immune responses in adult C. elegans.</title>
            <authorList>
                <person name="Block D.H."/>
                <person name="Twumasi-Boateng K."/>
                <person name="Kang H.S."/>
                <person name="Carlisle J.A."/>
                <person name="Hanganu A."/>
                <person name="Lai T.Y."/>
                <person name="Shapira M."/>
            </authorList>
            <dbReference type="PubMed" id="26016853"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005265"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2017" name="PLoS ONE" volume="12" first="e0177432" last="e0177432">
            <title>Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species.</title>
            <authorList>
                <person name="Hall J.A."/>
                <person name="McElwee M.K."/>
                <person name="Freedman J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28632756"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0177432"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2019" name="PLoS Genet." volume="15" first="e1007830" last="e1007830">
            <title>Global transcriptional regulation of innate immunity by ATF-7 in C. elegans.</title>
            <authorList>
                <person name="Fletcher M."/>
                <person name="Tillman E.J."/>
                <person name="Butty V.L."/>
                <person name="Levine S.S."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30789901"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1007830"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q86MD3-2</id>
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            <sequence type="described" ref="VSP_061039"/>
        </isoform>
        <isoform>
            <id>Q86MD3-1</id>
            <name evidence="5">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q86MD3-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_061042 VSP_061038 VSP_061040"/>
        </isoform>
        <isoform>
            <id>Q86MD3-3</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061041 VSP_061039"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_497913.1">
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    <dbReference type="WormBase" id="C07G2.2b">
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        <property type="component" value="Chromosome III"/>
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    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C07G2.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C07G2.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C07G2.2d"/>
        </source>
    </evidence>
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    <accession>Q86MD3-3</accession>
    <name>ATF7_CAEEL</name>
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            <fullName evidence="1">Isoform a of Transcription factor atf-7</fullName>
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    <gene>
        <name evidence="5" type="primary">atf-7</name>
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    <organism>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2010" name="PLoS Genet." volume="6" first="e1000892" last="e1000892">
            <title>Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shivers R.P."/>
                <person name="Pagano D.J."/>
                <person name="Kooistra T."/>
                <person name="Richardson C.E."/>
                <person name="Reddy K.C."/>
                <person name="Whitney J.K."/>
                <person name="Kamanzi O."/>
                <person name="Matsumoto K."/>
                <person name="Hisamoto N."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="20369020"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000892"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PMK-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-107</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="e1003324" last="e1003324">
            <title>RFX transcription factor DAF-19 regulates 5-HT and innate immune responses to pathogenic bacteria in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Xie Y."/>
                <person name="Moussaif M."/>
                <person name="Choi S."/>
                <person name="Xu L."/>
                <person name="Sze J.Y."/>
            </authorList>
            <dbReference type="PubMed" id="23505381"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003324"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005265" last="E1005265">
            <title>The developmental intestinal regulator ELT-2 controls p38-dependent immune responses in adult C. elegans.</title>
            <authorList>
                <person name="Block D.H."/>
                <person name="Twumasi-Boateng K."/>
                <person name="Kang H.S."/>
                <person name="Carlisle J.A."/>
                <person name="Hanganu A."/>
                <person name="Lai T.Y."/>
                <person name="Shapira M."/>
            </authorList>
            <dbReference type="PubMed" id="26016853"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005265"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2017" name="PLoS ONE" volume="12" first="e0177432" last="e0177432">
            <title>Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species.</title>
            <authorList>
                <person name="Hall J.A."/>
                <person name="McElwee M.K."/>
                <person name="Freedman J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28632756"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0177432"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2019" name="PLoS Genet." volume="15" first="e1007830" last="e1007830">
            <title>Global transcriptional regulation of innate immunity by ATF-7 in C. elegans.</title>
            <authorList>
                <person name="Fletcher M."/>
                <person name="Tillman E.J."/>
                <person name="Butty V.L."/>
                <person name="Levine S.S."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30789901"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1007830"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
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        <isoform>
            <id>Q86MD3-3</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061039 VSP_061041"/>
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        <isoform>
            <id>Q86MD3-2</id>
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            <id>Q86MD3-1</id>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C07G2.2d"/>
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    </evidence>
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    <accession>Q86MD3-4</accession>
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    <organism>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2010" name="PLoS Genet." volume="6" first="e1000892" last="e1000892">
            <title>Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shivers R.P."/>
                <person name="Pagano D.J."/>
                <person name="Kooistra T."/>
                <person name="Richardson C.E."/>
                <person name="Reddy K.C."/>
                <person name="Whitney J.K."/>
                <person name="Kamanzi O."/>
                <person name="Matsumoto K."/>
                <person name="Hisamoto N."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="20369020"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000892"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PMK-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-107</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="e1003324" last="e1003324">
            <title>RFX transcription factor DAF-19 regulates 5-HT and innate immune responses to pathogenic bacteria in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Xie Y."/>
                <person name="Moussaif M."/>
                <person name="Choi S."/>
                <person name="Xu L."/>
                <person name="Sze J.Y."/>
            </authorList>
            <dbReference type="PubMed" id="23505381"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003324"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005265" last="E1005265">
            <title>The developmental intestinal regulator ELT-2 controls p38-dependent immune responses in adult C. elegans.</title>
            <authorList>
                <person name="Block D.H."/>
                <person name="Twumasi-Boateng K."/>
                <person name="Kang H.S."/>
                <person name="Carlisle J.A."/>
                <person name="Hanganu A."/>
                <person name="Lai T.Y."/>
                <person name="Shapira M."/>
            </authorList>
            <dbReference type="PubMed" id="26016853"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005265"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2017" name="PLoS ONE" volume="12" first="e0177432" last="e0177432">
            <title>Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species.</title>
            <authorList>
                <person name="Hall J.A."/>
                <person name="McElwee M.K."/>
                <person name="Freedman J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28632756"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0177432"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2019" name="PLoS Genet." volume="15" first="e1007830" last="e1007830">
            <title>Global transcriptional regulation of innate immunity by ATF-7 in C. elegans.</title>
            <authorList>
                <person name="Fletcher M."/>
                <person name="Tillman E.J."/>
                <person name="Butty V.L."/>
                <person name="Levine S.S."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30789901"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1007830"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q86MD3-1</id>
            <name evidence="5">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q86MD3-3</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061039 VSP_061041"/>
        </isoform>
        <isoform>
            <id>Q86MD3-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_061038 VSP_061042 VSP_061040"/>
        </isoform>
        <isoform>
            <id>Q86MD3-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_061039"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379489.1">
        <property type="nucleotide sequence ID" value="NM_001393322.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C07G2.2d">
        <property type="protein sequence ID" value="CE42659"/>
        <property type="gene ID" value="WBGene00000223"/>
        <property type="gene designation" value="atf-7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C07G2.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C07G2.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C07G2.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C07G2.2d"/>
        </source>
    </evidence>
    <sequence length="373" mass="40023" checksum="249D017117FD09D6" modified="2003-06-01" version="1">MGDTTSPFSLDTPNPKLMFTPLDLPTTAELMQRCLAVNPFEAKFREANQKISSGSMQPNTSGANQSLEALEANGGSQFSGSNAGTMSDLLLKIPQASLQHSPGIFSNMLLNAGDSEGTTRENLKTADISKLLSVAGDFSAQAPRTADVLNAVLDMHSDRLHTINYLNNKPDFSALLRSPSSSAPNSASVLTNAMAIPSTSGAPFPGTTLLVPPKTVSSYHSPLGASSQPPSTQKSPADGSWDHINGEKQIKKEIPYFNDDAMMLMERSNMSSSGSDQDQSADMSNAGSTASTSTGNPVGRPQNGTPGRGRGRGRSTTADMQPDERRNTILERNKAAAVRYRKRKKEEHDDMMGRVQAMEAEKNQLLVRNEILY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-10-02" modified="2026-01-28" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>Q86ME6-2</accession>
    <name>DOPR1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform b of Dopamine receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Dopamine D1-like receptor dop-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dop-1</name>
        <name evidence="4" type="ORF">F15A8.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2002" name="Neurosci. Lett." volume="319" first="13" last="16">
            <title>Identification of a dopamine receptor from Caenorhabditis elegans.</title>
            <authorList>
                <person name="Suo S."/>
                <person name="Sasagawa N."/>
                <person name="Ishiura S."/>
            </authorList>
            <dbReference type="PubMed" id="11814642"/>
            <dbReference type="DOI" id="10.1016/s0304-3940(01)02477-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2004" name="EMBO J." volume="23" first="473" last="482">
            <title>Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Sanyal S."/>
                <person name="Wintle R.F."/>
                <person name="Kindt K.S."/>
                <person name="Nuttley W.M."/>
                <person name="Arvan R."/>
                <person name="Fitzmaurice P."/>
                <person name="Bigras E."/>
                <person name="Merz D.C."/>
                <person name="Hebert T.E."/>
                <person name="van der Kooy D."/>
                <person name="Schafer W.R."/>
                <person name="Culotti J.G."/>
                <person name="Van Tol H.H."/>
            </authorList>
            <dbReference type="PubMed" id="14739932"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600057"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2021" name="IScience" volume="24" first="102247" last="102247">
            <title>Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans.</title>
            <authorList>
                <person name="Xu Y."/>
                <person name="Zhang L."/>
                <person name="Liu Y."/>
                <person name="Topalidou I."/>
                <person name="Hassinan C."/>
                <person name="Ailion M."/>
                <person name="Zhao Z."/>
                <person name="Wang T."/>
                <person name="Chen Z."/>
                <person name="Bai J."/>
            </authorList>
            <dbReference type="PubMed" id="33796839"/>
            <dbReference type="DOI" id="10.1016/j.isci.2021.102247"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2022" name="Neurosci. Res." volume="178" first="87" last="92">
            <title>A role for dopamine in C. elegans avoidance behavior induced by mitochondrial stress.</title>
            <authorList>
                <person name="Chou S.H."/>
                <person name="Chen Y.J."/>
                <person name="Liao C.P."/>
                <person name="Pan C.L."/>
            </authorList>
            <dbReference type="PubMed" id="35074444"/>
            <dbReference type="DOI" id="10.1016/j.neures.2022.01.005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q86ME6-1</id>
            <name evidence="4">a</name>
            <name evidence="1">CeDOP1L</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q86ME6-3</id>
            <name evidence="6">c</name>
            <name evidence="1">CeDOP1S</name>
            <sequence type="described" ref="VSP_062403 VSP_062402"/>
        </isoform>
        <isoform>
            <id>Q86ME6-2</id>
            <name evidence="5">b</name>
            <name evidence="1">CeDOP1M</name>
            <sequence type="described" ref="VSP_062402"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024578.1">
        <property type="nucleotide sequence ID" value="NM_001029407.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F15A8.5b">
        <property type="protein sequence ID" value="CE33616"/>
        <property type="gene ID" value="WBGene00001052"/>
        <property type="gene designation" value="dop-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="11814642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F15A8.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F15A8.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F15A8.5c"/>
        </source>
    </evidence>
    <sequence length="402" mass="45857" checksum="06ABE42C0970CBF5" modified="2003-06-01" version="1">MNDLQWPLLGLFSVLIILALFGNLLVCAAILWDRSLRKQPENLFLVSLAVSDLLVSVLVMLFAAVNDILGYWPFGQFYCQFWISFDITTCTASILNLCAISLDRYWHISRPMVYIRYCNRRRINYVIVLVWLISAGIGAAPLGFGFGSKVTINNLTGLPVCEMRLPLPYAIGSSMVSFFLPAMVMVILYTKLYLYARKHVRSIKTQLQQATSFLIMQLASEKIREIRTSIFSKLNFLCPTRFKNQRSPQDPHTPAAHNRSNISDQKARLTLGVIMGTFLVCWLPFFTVNILRAWLPEIFSSKTIMAVTWLGYANSSANPLIYSIFNRDFRRAFKKIIVRVFGCCWEEPDLNKSISSRYAAPDNIERRRSCTRSSESAHDNNNDANATRLNLLSNNNEETIPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-10-02" modified="2026-01-28" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>Q86ME6-3</accession>
    <name>DOPR1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform c of Dopamine receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Dopamine D1-like receptor dop-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dop-1</name>
        <name evidence="4" type="ORF">F15A8.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2002" name="Neurosci. Lett." volume="319" first="13" last="16">
            <title>Identification of a dopamine receptor from Caenorhabditis elegans.</title>
            <authorList>
                <person name="Suo S."/>
                <person name="Sasagawa N."/>
                <person name="Ishiura S."/>
            </authorList>
            <dbReference type="PubMed" id="11814642"/>
            <dbReference type="DOI" id="10.1016/s0304-3940(01)02477-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2004" name="EMBO J." volume="23" first="473" last="482">
            <title>Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Sanyal S."/>
                <person name="Wintle R.F."/>
                <person name="Kindt K.S."/>
                <person name="Nuttley W.M."/>
                <person name="Arvan R."/>
                <person name="Fitzmaurice P."/>
                <person name="Bigras E."/>
                <person name="Merz D.C."/>
                <person name="Hebert T.E."/>
                <person name="van der Kooy D."/>
                <person name="Schafer W.R."/>
                <person name="Culotti J.G."/>
                <person name="Van Tol H.H."/>
            </authorList>
            <dbReference type="PubMed" id="14739932"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600057"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2021" name="IScience" volume="24" first="102247" last="102247">
            <title>Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans.</title>
            <authorList>
                <person name="Xu Y."/>
                <person name="Zhang L."/>
                <person name="Liu Y."/>
                <person name="Topalidou I."/>
                <person name="Hassinan C."/>
                <person name="Ailion M."/>
                <person name="Zhao Z."/>
                <person name="Wang T."/>
                <person name="Chen Z."/>
                <person name="Bai J."/>
            </authorList>
            <dbReference type="PubMed" id="33796839"/>
            <dbReference type="DOI" id="10.1016/j.isci.2021.102247"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2022" name="Neurosci. Res." volume="178" first="87" last="92">
            <title>A role for dopamine in C. elegans avoidance behavior induced by mitochondrial stress.</title>
            <authorList>
                <person name="Chou S.H."/>
                <person name="Chen Y.J."/>
                <person name="Liao C.P."/>
                <person name="Pan C.L."/>
            </authorList>
            <dbReference type="PubMed" id="35074444"/>
            <dbReference type="DOI" id="10.1016/j.neures.2022.01.005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q86ME6-2</id>
            <name evidence="5">b</name>
            <name evidence="1">CeDOP1M</name>
            <sequence type="described" ref="VSP_062402"/>
        </isoform>
        <isoform>
            <id>Q86ME6-1</id>
            <name evidence="4">a</name>
            <name evidence="1">CeDOP1L</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q86ME6-3</id>
            <name evidence="6">c</name>
            <name evidence="1">CeDOP1S</name>
            <sequence type="described" ref="VSP_062402 VSP_062403"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024579.1">
        <property type="nucleotide sequence ID" value="NM_001029408.5"/>
    </dbReference>
    <dbReference type="WormBase" id="F15A8.5c">
        <property type="protein sequence ID" value="CE33617"/>
        <property type="gene ID" value="WBGene00001052"/>
        <property type="gene designation" value="dop-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="11814642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F15A8.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F15A8.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F15A8.5c"/>
        </source>
    </evidence>
    <sequence length="399" mass="45526" checksum="40629EF6E074D048" modified="2003-06-01" version="1">MNDLQWPLLGLFSVLIILALFGNLLVCAAILWDRSLRKQPENLFLVSLAVSDLLVSVLVMLFAAVNDILGYWPFGQFYCQFWISFDITTCTASILNLCAISLDRYWHISRPMVYIRYCNRRRINYVIVLVWLISAGIGAAPLGFGFGSKVTINNLTGLPVCEMRLPLPYAIGSSMVSFFLPAMVMVILYTKLYLYARKHVRSIKTQLQQATSFLIMQLASEKIREIRTSIFSKLNFLCPTRFKNQRSPQDPHTPAAHNRSNISDQKARLTLGVIMGTFLVCWLPFFTVNILRAWLPEIFSSKTIMAVTWLGYANSSANPLIYSIFNRDFRRAFKKIIVRVFGCCWEEPDLNKSIYAAPDNIERRRSCTRSSESAHDNNNDANATRLNLLSNNNEETIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MYM0</accession>
    <name>Q8MYM0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">ztf-20</name>
        <name evidence="3" type="ORF">CELE_Y39B6A.46</name>
        <name evidence="5" type="ORF">Y39B6A.46</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAD31836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741651.1">
        <property type="nucleotide sequence ID" value="NM_171561.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MYM0"/>
    <dbReference type="DIP" id="DIP-25414N"/>
    <dbReference type="IntAct" id="Q8MYM0">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="PaxDb" id="6239-Y39B6A.46"/>
    <dbReference type="GeneID" id="189730"/>
    <dbReference type="UCSC" id="Y39B6A.46">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012702"/>
    <dbReference type="CTD" id="189730"/>
    <dbReference type="WormBase" id="Y39B6A.46a">
        <property type="protein sequence ID" value="CE29881"/>
        <property type="gene ID" value="WBGene00012702"/>
        <property type="gene designation" value="ztf-20"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R7NW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1120974_0_0_1"/>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="1999" name="FEBS Lett." volume="461" first="59" last="62">
            <title>In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin.</title>
            <authorList>
                <person name="Gieseler K."/>
                <person name="Abdel-Dayem M."/>
                <person name="Segalat L."/>
            </authorList>
            <dbReference type="PubMed" id="10561496"/>
            <dbReference type="DOI" id="10.1016/S0014-5793(99)01421-0"/>
        </citation>
        <scope>INTERACTION WITH DYB-1 AND DYS-1</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Gene" volume="294" first="77" last="86">
            <title>Genetic evidence for a dystrophin-glycoprotein complex (DGC) in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Grisoni K."/>
                <person name="Martin E."/>
                <person name="Gieseler K."/>
                <person name="Mariol M.-C."/>
                <person name="Segalat L."/>
            </authorList>
            <dbReference type="PubMed" id="12234669"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(02)00762-X"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2003" name="J. Mol. Biol." volume="332" first="1037" last="1046">
            <title>The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin.</title>
            <authorList>
                <person name="Grisoni K."/>
                <person name="Gieseler K."/>
                <person name="Mariol M.-C."/>
                <person name="Martin E."/>
                <person name="Carre-Pierrat M."/>
                <person name="Moulder G."/>
                <person name="Barstead R."/>
                <person name="Segalat L."/>
            </authorList>
            <dbReference type="PubMed" id="14499607"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2003.08.021"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INTERACTION WITH DYB-1</scope>
        <source>
            <strain evidence="1">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="891" last="896">
            <title>SNF-6 is an acetylcholine transporter interacting with the dystrophin complex in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kim H."/>
                <person name="Rogers M.J."/>
                <person name="Richmond J.E."/>
                <person name="McIntire S.L."/>
            </authorList>
            <dbReference type="PubMed" id="15318222"/>
            <dbReference type="DOI" id="10.1038/nature02798"/>
        </citation>
        <scope>INTERACTION WITH SNF-6</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q93646-2</id>
            <name evidence="1">b</name>
            <name>Beta</name>
            <sequence type="described" ref="VSP_051613"/>
        </isoform>
        <isoform>
            <id>Q93646-1</id>
            <name evidence="1">a</name>
            <name>Alpha</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="14499607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="14499607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAB03025.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47169" checksum="FDA3F126A038664F" modified="1997-02-01" version="1">MAAVRSGLVDIFVQGQWHRVLATLDPTAITLQTMEQNEAEAEKRTVRVVKYDGNGLGISIKGGRDNNMPIVISKIFKGMAADQAGELFLDDVIISVNGENLLDASHEEAVRALKRAGRVVDLQVQYRREDMMHRENIVENVEWDDDIRERVRTIGLKLAYVARAGIDADAEGRILEMRSPSGRYSLAMRCSSSEEADGWFEALHACTTCLLTQALAQVNIMLGNNPQVRHMGWIAEQVSENGISMWKPKFMTLTNSEILFYEAVPQLKAEWAEPRLVRPLVATRVVQTSSRTAPVIKGLTDVISFRMRTGTQQGVRTHTIRVETHAELARWVRAVVIGGYEACLSTSQVSAPCLWRGESCELIVNLDNGISLLSSTGEVLWQHSFETIRATGDDGGRFLWVDFGPPHGEQVKMDFILTLISYL</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-02-01" modified="2025-10-08" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q93652</accession>
    <name>Q93652_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F30F8.5</name>
        <name evidence="2 4" type="ORF">F30F8.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB03032.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21577">
        <property type="entry name" value="T21577"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_492168.2">
        <property type="nucleotide sequence ID" value="NM_059767.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q93652"/>
    <dbReference type="SMR" id="Q93652"/>
    <dbReference type="GeneID" id="185130"/>
    <dbReference type="UCSC" id="F30F8.5a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009274"/>
    <dbReference type="CTD" id="185130"/>
    <dbReference type="WormBase" id="F30F8.5a">
        <property type="protein sequence ID" value="CE37511"/>
        <property type="gene ID" value="WBGene00009274"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001972_0_0_1"/>
    <dbReference type="OrthoDB" id="6497308at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009274">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q93652">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB03032.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F30F8.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q93652"/>
        </source>
    </evidence>
    <sequence length="248" mass="27889" checksum="3B9DFCDB238083DE" modified="2004-11-23" version="2">MDTTTTSSLKSAEKKDTDATPRAHSPEIDVEVIKSDCSTPEKQNGAVGNEQQMNNSTSTRRTDSNKNLSPPPQRLRTSSSTSDGTENLISSLSSWDWVTIDGLKLPAVTRNKERYVAVHMVQLKLLSKFPSDIPRDITRKFTMGSHKMTVTEAWTFNTINAVIRKFDLGCQLFTANDELVKLNDVQMFYWNVKLFNLKRVNGQYETAISSAENNVQLLATAMQLKKQVDSDIQAVCAELKRLEKSYCE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q95XX1-2</accession>
    <name>PNCB_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Nicotinate phosphoribosyltransferase</fullName>
            <shortName evidence="1">NAPRTase</shortName>
            <ecNumber evidence="1">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nprt-1</name>
        <name evidence="3" type="ORF">Y54G2A.17</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95XX1-2</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_030613"/>
        </isoform>
        <isoform>
            <id>Q95XX1-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95XX1-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_030613 VSP_042230 VSP_042231"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001380099.1">
        <property type="nucleotide sequence ID" value="NM_001392274.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y54G2A.17a">
        <property type="protein sequence ID" value="CE46116"/>
        <property type="gene ID" value="WBGene00021882"/>
        <property type="gene designation" value="nprt-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P18133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="Y54G2A.17a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y54G2A.17b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y54G2A.17c"/>
        </source>
    </evidence>
    <sequence length="542" mass="61209" checksum="F598BA246D6E6113" modified="2012-01-25" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q95XX1-3</accession>
    <name>PNCB_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Nicotinate phosphoribosyltransferase</fullName>
            <shortName evidence="1">NAPRTase</shortName>
            <ecNumber evidence="1">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nprt-1</name>
        <name evidence="3" type="ORF">Y54G2A.17</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95XX1-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_042230 VSP_030613 VSP_042231"/>
        </isoform>
        <isoform>
            <id>Q95XX1-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95XX1-2</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_030613"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001368085.1">
        <property type="nucleotide sequence ID" value="NM_001380118.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y54G2A.17c">
        <property type="protein sequence ID" value="CE33887"/>
        <property type="gene ID" value="WBGene00021882"/>
        <property type="gene designation" value="nprt-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P18133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="Y54G2A.17a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y54G2A.17b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y54G2A.17c"/>
        </source>
    </evidence>
    <sequence length="238" mass="26512" checksum="12F03D8AFC08D90D" modified="2012-01-25" version="3">MNGQDSLVQPLLTDFYQITMCYAYWKTGTHNEPAVFDVFFRKNPFQGEFTVFAGLEDCLRFVENFKFSQSDIDYVKKILPENAEPEFYEYLETLNGSHLTIEAVAEGSVVFPKVPLLTINGPLAMCQLIETSILNLVNYASLVATNAARFRQASGWKIQLLEFGLRRAQGPNGGLTASKYCYIGGFDATSNVLAGKLYGIPVKGTQAHSFICSFSSPAEVEHYLSIMGDFALNSSLWF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q965X9-2</accession>
    <name>NAPE2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2</fullName>
            <shortName evidence="2">NAPE-2</shortName>
            <ecNumber evidence="1">3.1.4.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">nape-2</name>
        <name evidence="4" type="ORF">Y37E11AR.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="e113007" last="e113007">
            <title>Characterization of N-acyl phosphatidylethanolamine-specific phospholipase-D isoforms in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Harrison N."/>
                <person name="Lone M.A."/>
                <person name="Kaul T.K."/>
                <person name="Reis Rodrigues P."/>
                <person name="Ogungbe I.V."/>
                <person name="Gill M.S."/>
            </authorList>
            <dbReference type="PubMed" id="25423491"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0113007"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative initiation"/>
        <isoform>
            <id>Q965X9-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_061049"/>
        </isoform>
        <isoform>
            <id>Q965X9-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q965X9-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_061050"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.4.54" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001368057.1">
        <property type="nucleotide sequence ID" value="NM_001380159.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y37E11AR.3b">
        <property type="protein sequence ID" value="CE28519"/>
        <property type="gene ID" value="WBGene00021370"/>
        <property type="gene designation" value="nape-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="25423491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="25423491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="CCD74039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y37E11AR.3a"/>
        </source>
    </evidence>
    <sequence length="376" mass="42636" checksum="5B1081000511F681" modified="2001-12-01" version="1">MRTSFRKRFYRLVACAAGGVVMSAPTTSSSTDEDFAKPVKNGKTFANPKSFTNWGGIPGISDGFKFAFTETNHENVPCDKKILDVEIPVHNITADDFHSESDLFATWLGHATVLVDLEGVKFVTDPVWADRASFTSFAGPKRYRPPPMKLEDLPDLDFAVVSHDHYDHLDADAVKKITDRNPQIKWFVPLGMKKWMEGQGIGVDGSSTAVTELNWGESSEFVKNGKTYTIWCLPAQHWGQRGLFDRNHRLWSGWAVIGENRRFYYSGDTGHCDGEFKKFGEKLGPFDLAAIPIGAYEPRWFMKSQHINPEEAIEVHKLIRAKNSIGIHWGTYHMGSTEYYLEPRDKLKELMDAREDLKNTSFVTIEMGRIWEASDQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q965X9-3</accession>
    <name>NAPE2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2</fullName>
            <shortName evidence="2">NAPE-2</shortName>
            <ecNumber evidence="1">3.1.4.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">nape-2</name>
        <name evidence="4" type="ORF">Y37E11AR.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="e113007" last="e113007">
            <title>Characterization of N-acyl phosphatidylethanolamine-specific phospholipase-D isoforms in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Harrison N."/>
                <person name="Lone M.A."/>
                <person name="Kaul T.K."/>
                <person name="Reis Rodrigues P."/>
                <person name="Ogungbe I.V."/>
                <person name="Gill M.S."/>
            </authorList>
            <dbReference type="PubMed" id="25423491"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0113007"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative initiation"/>
        <isoform>
            <id>Q965X9-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_061049"/>
        </isoform>
        <isoform>
            <id>Q965X9-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q965X9-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_061050"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.4.54" evidence="1"/>
    <dbReference type="RefSeq" id="NP_741361.1">
        <property type="nucleotide sequence ID" value="NM_171307.5"/>
    </dbReference>
    <dbReference type="WormBase" id="Y37E11AR.3c">
        <property type="protein sequence ID" value="CE31637"/>
        <property type="gene ID" value="WBGene00021370"/>
        <property type="gene designation" value="nape-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="25423491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="25423491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="CCD74039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y37E11AR.3a"/>
        </source>
    </evidence>
    <sequence length="376" mass="42545" checksum="8B0E6C92E5671BBF" modified="2001-12-01" version="1">MFVPVVMTIVLLLYATSDSVVMSAPTTSSSTDEDFAKPVKNGKTFANPKSFTNWGGIPGISDGFKFAFTETNHENVPCDKKILDVEIPVHNITADDFHSESDLFATWLGHATVLVDLEGVKFVTDPVWADRASFTSFAGPKRYRPPPMKLEDLPDLDFAVVSHDHYDHLDADAVKKITDRNPQIKWFVPLGMKKWMEGQGIGVDGSSTAVTELNWGESSEFVKNGKTYTIWCLPAQHWGQRGLFDRNHRLWSGWAVIGENRRFYYSGDTGHCDGEFKKFGEKLGPFDLAAIPIGAYEPRWFMKSQHINPEEAIEVHKLIRAKNSIGIHWGTYHMGSTEYYLEPRDKLKELMDAREDLKNTSFVTIEMGRIWEASDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N4A8</accession>
    <name>Q9N4A8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y77E11A.12</name>
        <name evidence="3 5" type="ORF">Y77E11A.12</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD72597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023582.1">
        <property type="nucleotide sequence ID" value="NM_001028411.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N4A8"/>
    <dbReference type="GeneID" id="259552"/>
    <dbReference type="KEGG" id="cel:CELE_Y77E11A.12"/>
    <dbReference type="UCSC" id="Y77E11A.12b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022313"/>
    <dbReference type="CTD" id="259552"/>
    <dbReference type="WormBase" id="Y77E11A.12a">
        <property type="protein sequence ID" value="CE26307"/>
        <property type="gene ID" value="WBGene00022313"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_406656_0_0_1"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022313">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N4A8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD72597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y77E11A.12a"/>
        </source>
    </evidence>
    <sequence length="544" mass="62400" checksum="43AAEE12D0B022E6" modified="2002-10-01" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q9U226-2</accession>
    <name>TAF12_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Transcription initiation factor TFIID subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">taf-12</name>
        <name evidence="3" type="ORF">Y56A3A.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2008" name="Cell" volume="135" first="149" last="160">
            <title>Global transcriptional repression in C. elegans germline precursors by regulated sequestration of TAF-4.</title>
            <authorList>
                <person name="Guven-Ozkan T."/>
                <person name="Nishi Y."/>
                <person name="Robertson S.M."/>
                <person name="Lin R."/>
            </authorList>
            <dbReference type="PubMed" id="18854162"/>
            <dbReference type="DOI" id="10.1016/j.cell.2008.07.040"/>
        </citation>
        <scope>INTERACTION WITH TAF-4</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9U226-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9U226-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_061417"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255145.1">
        <property type="nucleotide sequence ID" value="NM_001268216.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y56A3A.4b">
        <property type="protein sequence ID" value="CE43550"/>
        <property type="gene ID" value="WBGene00006396"/>
        <property type="gene designation" value="taf-12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y56A3A.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y56A3A.4b"/>
        </source>
    </evidence>
    <sequence length="309" mass="34670" checksum="BC934A24C8114B61" modified="2002-10-01" version="2">MQQGIPPQGHQNPNEQQQQQQFVGQPPMGGMGGPMRMQMPQQQIRQMPYPSPQMRAGPPPPQQQQQQHFQQMGIPQQQQPQQFTPNGQSMQMQQRPMQMGMAQGPGPSGHLMGMVGGPPPQHMMQQQGGGGPPQFVPNSSPMPLPPQQIMQVQHQQQHQQPPPSQQIQQPPIPQPQQQQAPPPQMIPAAVPYGSIMEKSKLDDLMQQISSTTVLEENVKDVLVEYADDFVSSLIDKACKMIKNREVKKIESRDIEFILKNVYNMPVVPRAASHNFGSQTEVIDLSKEKFVPTEAHKQRVALLKKQIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4PFB3</accession>
    <name>U4PFB3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATF7IP_BD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_R08C7.5</name>
        <name evidence="2 4" type="ORF">R08C7.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294625.1">
        <property type="nucleotide sequence ID" value="NM_001307696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PFB3"/>
    <dbReference type="SMR" id="U4PFB3"/>
    <dbReference type="GeneID" id="177207"/>
    <dbReference type="AGR" id="WB:WBGene00019949"/>
    <dbReference type="CTD" id="177207"/>
    <dbReference type="WormBase" id="R08C7.5b">
        <property type="protein sequence ID" value="CE48824"/>
        <property type="gene ID" value="WBGene00019949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019949">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PFB3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R08C7.5b"/>
        </source>
    </evidence>
    <sequence length="421" mass="46461" checksum="2FE6D36B5C795090" modified="2013-12-11" version="1">MVFTRSSSRNHTKSDVAGAGPTWDEFLKVDGMSQKLQECENQFEKASNKVFAELFAKLNDVAKKVATEDFPAEQLQKLIDRNYPKPPGFKDVKVEEIEAEEHDELIETAMYLSDASEGGEITMNTEPPGFEEVKAEELKAEEHDDHMDTAMLLDPDSTQDGEEVTMKPVSQDISELSGEEDPDETLIQNTTLHMDNLSMKEELNADTTIVTSTPIRACSTKIMVPVVRPEISPVEKPISSSTHCRNLLNLNPKMPVFTSMFGKMKQEPGVESSHVSNLRQKILNHRKRGKEVQKVPSSPPPKLPKTVVQPSKEEKPTAVIESKLKNSGSTSETSHKFPTTKDPKNRSSTSERKETSHGICENRGSTSEGDQADCCQNNGESGRTCSSKGSETGKSSNSQTGKARHVVQNDSNTRPQAEIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4PFC3</accession>
    <name>U4PFC3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal_L2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">mrpl-2</name>
        <name evidence="1" type="ORF">CELE_F56B3.8</name>
        <name evidence="3" type="ORF">F56B3.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368336.1">
        <property type="nucleotide sequence ID" value="NM_001380018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PFC3"/>
    <dbReference type="SMR" id="U4PFC3"/>
    <dbReference type="PeptideAtlas" id="U4PFC3"/>
    <dbReference type="GeneID" id="176903"/>
    <dbReference type="KEGG" id="cel:CELE_F56B3.8"/>
    <dbReference type="AGR" id="WB:WBGene00018932"/>
    <dbReference type="CTD" id="176903"/>
    <dbReference type="WormBase" id="F56B3.8b">
        <property type="protein sequence ID" value="CE48558"/>
        <property type="gene ID" value="WBGene00018932"/>
        <property type="gene designation" value="mrpl-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_1_1_1"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018932">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PFC3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F56B3.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="U4PFC3"/>
        </source>
    </evidence>
    <sequence length="70" mass="7808" checksum="779DA13470760681" modified="2013-12-11" version="1">MSSGLFHKKDGYFGRKVRALPPVRILDTPPQAPPPNQRFTLSKKDLSGLHGHAKVHNLIPAGYSTRDYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>W6RT88</accession>
    <name>W6RT88_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Grh/CP2 DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">grh-1</name>
        <name evidence="9" type="ORF">CELE_Y48G8AR.1</name>
        <name evidence="11" type="ORF">Y48G8AR.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293411.1">
        <property type="nucleotide sequence ID" value="NM_001306482.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RT88"/>
    <dbReference type="SMR" id="W6RT88"/>
    <dbReference type="GeneID" id="190048"/>
    <dbReference type="AGR" id="WB:WBGene00001707"/>
    <dbReference type="CTD" id="190048"/>
    <dbReference type="WormBase" id="Y48G8AR.1b">
        <property type="protein sequence ID" value="CE49585"/>
        <property type="gene ID" value="WBGene00001707"/>
        <property type="gene designation" value="grh-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7680836at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RT88">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="8">
        <location>
            <begin position="194"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM63467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y48G8AR.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="W6RT88"/>
        </source>
    </evidence>
    <sequence length="563" mass="64163" checksum="9B4FB85D4BA1859F" modified="2014-04-16" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-04-22" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A163UT06-2</accession>
    <name>SET17_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Histone-lysine N-methyltransferase set-17</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
            <ecNumber evidence="1">2.1.1.364</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">set-17</name>
        <name evidence="4" type="ORF">T21B10.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2014" name="Cell Rep." volume="7" first="113" last="126">
            <title>A histone methylation network regulates transgenerational epigenetic memory in C. elegans.</title>
            <authorList>
                <person name="Greer E.L."/>
                <person name="Beese-Sims S.E."/>
                <person name="Brookes E."/>
                <person name="Spadafora R."/>
                <person name="Zhu Y."/>
                <person name="Rothbart S.B."/>
                <person name="Aristizabal-Corrales D."/>
                <person name="Chen S."/>
                <person name="Badeaux A.I."/>
                <person name="Jin Q."/>
                <person name="Wang W."/>
                <person name="Strahl B.D."/>
                <person name="Colaiacovo M.P."/>
                <person name="Shi Y."/>
            </authorList>
            <dbReference type="PubMed" id="24685137"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2014.02.044"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 1-MET--PHE-135</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2018" name="PLoS Genet." volume="14" first="E1007295" last="E1007295">
            <title>A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility.</title>
            <authorList>
                <person name="Engert C.G."/>
                <person name="Droste R."/>
                <person name="van Oudenaarden A."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="29702639"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1007295"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 1-MET--PHE-135 AND 84-TYR--ARG-277</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A163UT06-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_060571"/>
        </isoform>
        <isoform>
            <id>A0A163UT06-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EC" id="2.1.1.364" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001368599.1">
        <property type="nucleotide sequence ID" value="NM_001381544.1"/>
    </dbReference>
    <dbReference type="WormBase" id="T21B10.5b">
        <property type="protein sequence ID" value="CE51577"/>
        <property type="gene ID" value="WBGene00011887"/>
        <property type="gene designation" value="set-17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="24685137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T21B10.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T21B10.5b"/>
        </source>
    </evidence>
    <sequence length="265" mass="30488" checksum="3C5B7EFB4F87A183" modified="2016-07-06" version="1">MNGIQIPGISNPEAIIPITGEKKSYKLVLDFNDGAISIIEARYLDSKLHREIQDLSDNDVTILGTEISDGAYDENLDIHCDKCNKFYRPYCRLHPLFKIPDRVLKRDESSNLSFSQQTLPILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGRRCQKKTDFYKDGYAWLIKSGDKRFYIDGSDAERSNWLRYINSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYGSSYGNEFVESENGNKYKKPAKNPFICVGAQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-01-31" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSL9-10</accession>
    <name>AJM1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform 10 of Apical junction molecule ajm-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">jam-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ajm-1</name>
        <name evidence="3" type="ORF">C25A11.4</name>
        <name type="ORF">CELE_C25A11.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nat. Cell Biol." volume="3" first="983" last="991">
            <title>Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia.</title>
            <authorList>
                <person name="Koeppen M."/>
                <person name="Simske J.S."/>
                <person name="Sims P.A."/>
                <person name="Firestein B.L."/>
                <person name="Hall D.H."/>
                <person name="Radice A.D."/>
                <person name="Rongo C."/>
                <person name="Hardin J.D."/>
            </authorList>
            <dbReference type="PubMed" id="11715019"/>
            <dbReference type="DOI" id="10.1038/ncb1101-983"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INTERACTION WITH DLG-1</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="J. Cell Sci." volume="121" first="1477" last="1487">
            <title>Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.</title>
            <authorList>
                <person name="Lockwood C.A."/>
                <person name="Lynch A.M."/>
                <person name="Hardin J."/>
            </authorList>
            <dbReference type="PubMed" id="18411252"/>
            <dbReference type="DOI" id="10.1242/jcs.017137"/>
        </citation>
        <scope>INTERACTION WITH DLG-1</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="Dev. Cell" volume="38" first="493" last="506">
            <title>A Conserved role for girdin in basal body positioning and ciliogenesis.</title>
            <authorList>
                <person name="Nechipurenko I.V."/>
                <person name="Olivier-Mason A."/>
                <person name="Kazatskaya A."/>
                <person name="Kennedy J."/>
                <person name="McLachlan I.G."/>
                <person name="Heiman M.G."/>
                <person name="Blacque O.E."/>
                <person name="Sengupta P."/>
            </authorList>
            <dbReference type="PubMed" id="27623382"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2016.07.013"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A1C3NSL9-4</id>
            <name>4</name>
            <sequence type="described" ref="VSP_059291"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-3</id>
            <name>3</name>
            <sequence type="described" ref="VSP_059286"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-8</id>
            <name>8</name>
            <sequence type="described" ref="VSP_059294 VSP_059293"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-5</id>
            <name>5</name>
            <sequence type="described" ref="VSP_059292"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-2</id>
            <name>2</name>
            <sequence type="described" ref="VSP_059285"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-9</id>
            <name>9</name>
            <sequence type="described" ref="VSP_059290"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-11</id>
            <name>11</name>
            <sequence type="described" ref="VSP_059287"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-6</id>
            <name>6</name>
            <sequence type="described" ref="VSP_059293"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-10</id>
            <name>10</name>
            <sequence type="described" ref="VSP_059289"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-7</id>
            <name>7</name>
            <sequence type="described" ref="VSP_059288"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367381.1">
        <property type="nucleotide sequence ID" value="NM_001381048.1"/>
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        <property type="protein sequence ID" value="CE27083"/>
        <property type="gene ID" value="WBGene00000100"/>
        <property type="gene designation" value="ajm-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C25A11.4a"/>
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    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C25A11.4k"/>
        </source>
    </evidence>
    <sequence length="1480" mass="175237" checksum="EC9FAA97040EC7BA" modified="2016-11-02" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-01-31" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSL9-11</accession>
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        <recommendedName>
            <fullName evidence="2">Isoform 11 of Apical junction molecule ajm-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">jam-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ajm-1</name>
        <name evidence="3" type="ORF">C25A11.4</name>
        <name type="ORF">CELE_C25A11.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nat. Cell Biol." volume="3" first="983" last="991">
            <title>Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia.</title>
            <authorList>
                <person name="Koeppen M."/>
                <person name="Simske J.S."/>
                <person name="Sims P.A."/>
                <person name="Firestein B.L."/>
                <person name="Hall D.H."/>
                <person name="Radice A.D."/>
                <person name="Rongo C."/>
                <person name="Hardin J.D."/>
            </authorList>
            <dbReference type="PubMed" id="11715019"/>
            <dbReference type="DOI" id="10.1038/ncb1101-983"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INTERACTION WITH DLG-1</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="J. Cell Sci." volume="121" first="1477" last="1487">
            <title>Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.</title>
            <authorList>
                <person name="Lockwood C.A."/>
                <person name="Lynch A.M."/>
                <person name="Hardin J."/>
            </authorList>
            <dbReference type="PubMed" id="18411252"/>
            <dbReference type="DOI" id="10.1242/jcs.017137"/>
        </citation>
        <scope>INTERACTION WITH DLG-1</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="Dev. Cell" volume="38" first="493" last="506">
            <title>A Conserved role for girdin in basal body positioning and ciliogenesis.</title>
            <authorList>
                <person name="Nechipurenko I.V."/>
                <person name="Olivier-Mason A."/>
                <person name="Kazatskaya A."/>
                <person name="Kennedy J."/>
                <person name="McLachlan I.G."/>
                <person name="Heiman M.G."/>
                <person name="Blacque O.E."/>
                <person name="Sengupta P."/>
            </authorList>
            <dbReference type="PubMed" id="27623382"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2016.07.013"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A1C3NSL9-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-9</id>
            <name>9</name>
            <sequence type="described" ref="VSP_059290"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-11</id>
            <name>11</name>
            <sequence type="described" ref="VSP_059287"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-2</id>
            <name>2</name>
            <sequence type="described" ref="VSP_059285"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-4</id>
            <name>4</name>
            <sequence type="described" ref="VSP_059291"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-10</id>
            <name>10</name>
            <sequence type="described" ref="VSP_059289"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-3</id>
            <name>3</name>
            <sequence type="described" ref="VSP_059286"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-7</id>
            <name>7</name>
            <sequence type="described" ref="VSP_059288"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-5</id>
            <name>5</name>
            <sequence type="described" ref="VSP_059292"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-8</id>
            <name>8</name>
            <sequence type="described" ref="VSP_059293 VSP_059294"/>
        </isoform>
        <isoform>
            <id>A0A1C3NSL9-6</id>
            <name>6</name>
            <sequence type="described" ref="VSP_059293"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001317898.1">
        <property type="nucleotide sequence ID" value="NM_001330913.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C25A11.4i">
        <property type="protein sequence ID" value="CE51744"/>
        <property type="gene ID" value="WBGene00000100"/>
        <property type="gene designation" value="ajm-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C25A11.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C25A11.4k"/>
        </source>
    </evidence>
    <sequence length="1300" mass="156389" checksum="753E213AD7B8D061" modified="2016-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1E3Y0</accession>
    <name>A0A3B1E3Y0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mec-2</name>
        <name evidence="7" type="ORF">CELE_F14D12.4</name>
        <name evidence="9" type="ORF">F14D12.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368714.1">
        <property type="nucleotide sequence ID" value="NM_001380976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1E3Y0"/>
    <dbReference type="SMR" id="A0A3B1E3Y0"/>
    <dbReference type="GeneID" id="180826"/>
    <dbReference type="AGR" id="WB:WBGene00003166"/>
    <dbReference type="CTD" id="180826"/>
    <dbReference type="WormBase" id="F14D12.4g">
        <property type="protein sequence ID" value="CE52733"/>
        <property type="gene ID" value="WBGene00003166"/>
        <property type="gene designation" value="mec-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003166">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1E3Y0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
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        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="64"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="861"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1116"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="358"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="559"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="676"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="750"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1116"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VAY52613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F14D12.4g"/>
        </source>
    </evidence>
    <sequence length="1164" mass="128599" checksum="BDFCE485F16E902D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-10-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A565CXN2</accession>
    <name>A0A565CXN2_CAEEL</name>
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        <submittedName>
            <fullName evidence="6">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nhr-62</name>
        <name evidence="6" type="ORF">CELE_Y67A6A.2</name>
        <name evidence="8" type="ORF">Y67A6A.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="VVB27840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368765.1">
        <property type="nucleotide sequence ID" value="NM_001381160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A565CXN2"/>
    <dbReference type="SMR" id="A0A565CXN2"/>
    <dbReference type="GeneID" id="172836"/>
    <dbReference type="AGR" id="WB:WBGene00003652"/>
    <dbReference type="CTD" id="172836"/>
    <dbReference type="WormBase" id="Y67A6A.2d">
        <property type="protein sequence ID" value="CE53607"/>
        <property type="gene ID" value="WBGene00003652"/>
        <property type="gene designation" value="nhr-62"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817395at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A565CXN2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052499">
        <property type="entry name" value="C.elegans_NHRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630:SF4">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="63"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VVB27840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y67A6A.2d"/>
        </source>
    </evidence>
    <sequence length="350" mass="39918" checksum="4DB3E0EB90610637" modified="2019-10-16" version="1">MNPRAVQSERVEREQNGSPNQIEEDDYKDLSSPDTCSVEIQTDVDEQKPSSNNSAPLPSMELEMAKLSEQIVEMHRAVCSYVDPVTKRENFDMKMETETTKIAFMNAFYNPEMIGPRTPLDITGRRVATVKDVMDEWKRNFVLFSDWLRALPEYNQMSIEDQIVLAKNRYGTFHWWMCANWTVQAGCEGVCYSNGAYFPKQPEAQCIPDVKGSSGRMYDSLSIPIKELNLDETEIVLMLAVIIFSDELADLTPAGKEHVRMVGNRFVRMLHHHVNSKEYGEAMENGDDTQNSSESQAAVRIAKMMILLSATTNLVYLTSDNIQLMEVLHVVPSEYLCHEVQFIQNSYETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D7ZEP4</accession>
    <name>A0A8D7ZEP4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">unc-103</name>
        <name evidence="19" type="ORF">C30D11.1</name>
        <name evidence="17" type="ORF">CELE_C30D11.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAG4685891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001407488.1">
        <property type="nucleotide sequence ID" value="NM_001420613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D7ZEP4"/>
    <dbReference type="SMR" id="A0A8D7ZEP4"/>
    <dbReference type="GeneID" id="175527"/>
    <dbReference type="AGR" id="WB:WBGene00006830"/>
    <dbReference type="CTD" id="175527"/>
    <dbReference type="WormBase" id="C30D11.1m">
        <property type="protein sequence ID" value="CE54332"/>
        <property type="gene ID" value="WBGene00006830"/>
        <property type="gene designation" value="unc-103"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000020">
        <property type="entry name" value="Potassium channel, voltage-gated eag-related subfamily H, member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000001">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000107">
        <property type="entry name" value="Potassium voltage-gated channel unc-103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003967">
        <property type="entry name" value="K_chnl_volt-dep_ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF548">
        <property type="entry name" value="GH12235P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01470">
        <property type="entry name" value="ERGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="389"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="532"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG4685891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="C30D11.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8D7ZEP4"/>
        </source>
    </evidence>
    <sequence length="760" mass="85652" checksum="F5158F66328CD0A0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D7ZET0</accession>
    <name>A0A8D7ZET0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mctp-1</name>
        <name evidence="6" type="ORF">CELE_D2092.1</name>
        <name evidence="8" type="ORF">D2092.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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        </location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG4685895.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
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    <dbReference type="GO" id="GO:0061733">
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045141">
        <property type="entry name" value="NAA60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744:SF15">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG4685881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F30F8.10c"/>
        </source>
    </evidence>
    <sequence length="96" mass="10998" checksum="EB11524E8F09E85C" modified="2022-01-19" version="1">MSSLSDHPPYPRAVFLHVLSTNSAALSFYKMHGFEFHASLPYFREYYRIGEQLADGCTYVKYINGTYTNVTFTDVCRTFGNTICMPLKAICKMLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D7ZF36</accession>
    <name>A0A8D7ZF36_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">unc-103</name>
        <name evidence="19" type="ORF">C30D11.1</name>
        <name evidence="17" type="ORF">CELE_C30D11.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAG4685890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001382275.1">
        <property type="nucleotide sequence ID" value="NM_001395354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D7ZF36"/>
    <dbReference type="SMR" id="A0A8D7ZF36"/>
    <dbReference type="GeneID" id="175527"/>
    <dbReference type="AGR" id="WB:WBGene00006830"/>
    <dbReference type="CTD" id="175527"/>
    <dbReference type="WormBase" id="C30D11.1l">
        <property type="protein sequence ID" value="CE54338"/>
        <property type="gene ID" value="WBGene00006830"/>
        <property type="gene designation" value="unc-103"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000020">
        <property type="entry name" value="Potassium channel, voltage-gated eag-related subfamily H, member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000001">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium voltage-gated channel unc-103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003967">
        <property type="entry name" value="K_chnl_volt-dep_ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF548">
        <property type="entry name" value="GH12235P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01470">
        <property type="entry name" value="ERGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="392"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="535"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG4685890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="C30D11.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8D7ZF36"/>
        </source>
    </evidence>
    <sequence length="686" mass="77759" checksum="9F606645F19D7267" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D7ZGA2</accession>
    <name>A0A8D7ZGA2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">unc-103</name>
        <name evidence="19" type="ORF">C30D11.1</name>
        <name evidence="17" type="ORF">CELE_C30D11.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAG4685889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001407487.1">
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    <dbReference type="CTD" id="175527"/>
    <dbReference type="WormBase" id="C30D11.1k">
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        <property type="gene ID" value="WBGene00006830"/>
        <property type="gene designation" value="unc-103"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000001">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
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    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003967">
        <property type="entry name" value="K_chnl_volt-dep_ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF548">
        <property type="entry name" value="GH12235P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
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</entry>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <property type="protein sequence ID" value="CE39676"/>
        <property type="gene ID" value="WBGene00015887"/>
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    <dbReference type="HOGENOM" id="CLU_032690_3_0_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015887">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B0M0L9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA thioesterase II"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
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        <property type="entry name" value="ACOT8-like_C"/>
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    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00189">
        <property type="entry name" value="tesB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="5">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="6">
        <location>
            <begin position="206"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD64833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C17C3.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="B0M0L9"/>
        </source>
    </evidence>
    <sequence length="326" mass="37434" checksum="DD6161A6E8323B72" modified="2008-03-18" version="1">MTTVPLKSEFKKVNNFQEIAHKFFDFTELKKDSFSPSTLSNGRQAHHGAAYGGLIFSQALAAAEKTVDEQFKPHSMHSYFILNVDTKEPISYNVRRIRDGRSFITRTVEAVQKDKVCFVLQCSFHVEEKSSIIHQSEMPKVPEPEVLMSMRDAVPYMKELVEKGEVTPPPAMLARLQSYDSKVYSDDQDLFEMRCTNLGNYYGFASDKKPELYFWMRARGDLSNDERFHRWLIAYNSDSLLVSTAVSPHYTTGFCSSMLFSLDHCVWFHRSEVKADEWLLFECKSRIASGSRATIEGRIWRRDGVLIASCQQEALVRSKSDEPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-03-18" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>B0M0N9</accession>
    <name>B0M0N9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">L-glutamine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">glna-1</name>
        <name evidence="14" type="ORF">C09F9.3</name>
        <name evidence="12" type="ORF">CELE_C09F9.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAP72487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_497054.2">
        <property type="nucleotide sequence ID" value="NM_064653.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0M0N9"/>
    <dbReference type="SMR" id="B0M0N9"/>
    <dbReference type="PeptideAtlas" id="B0M0N9"/>
    <dbReference type="GeneID" id="175130"/>
    <dbReference type="AGR" id="WB:WBGene00007480"/>
    <dbReference type="CTD" id="175130"/>
    <dbReference type="WormBase" id="C09F9.3a">
        <property type="protein sequence ID" value="CE42058"/>
        <property type="gene ID" value="WBGene00007480"/>
        <property type="gene designation" value="glna-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007480">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B0M0N9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000069">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.710.10:FF:000008">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041541">
        <property type="entry name" value="Glutaminase_EF-hand"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF29">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17959">
        <property type="entry name" value="EF-hand_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Glutaminase EF-hand" evidence="11">
        <location>
            <begin position="77"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="613"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="694"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAP72487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="C09F9.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="B0M0N9"/>
        </source>
    </evidence>
    <sequence length="791" mass="89573" checksum="B9D7B3465A2848C5" modified="2008-03-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-03-18" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>B0M0P0</accession>
    <name>B0M0P0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">L-glutamine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">glna-1</name>
        <name evidence="14" type="ORF">C09F9.3</name>
        <name evidence="12" type="ORF">CELE_C09F9.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAP72488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367181.1">
        <property type="nucleotide sequence ID" value="NM_001381664.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0M0P0"/>
    <dbReference type="SMR" id="B0M0P0"/>
    <dbReference type="GeneID" id="175130"/>
    <dbReference type="AGR" id="WB:WBGene00007480"/>
    <dbReference type="CTD" id="175130"/>
    <dbReference type="WormBase" id="C09F9.3b">
        <property type="protein sequence ID" value="CE42229"/>
        <property type="gene ID" value="WBGene00007480"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Glutaminase EF-hand" evidence="11">
        <location>
            <begin position="77"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="696"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
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        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17959"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAP72488.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="C09F9.3b"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="B0M0P0"/>
        </source>
    </evidence>
    <sequence length="793" mass="89773" checksum="D57D37D1408BB440" modified="2008-03-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-02-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>E4MVC8</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="2 4" type="primary">srh-2</name>
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        <name evidence="2" type="ORF">CELE_C05E4.14</name>
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    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD63248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021364.2">
        <property type="nucleotide sequence ID" value="NM_001026193.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E4MVC8"/>
    <dbReference type="GeneID" id="178584"/>
    <dbReference type="KEGG" id="cel:CELE_C05E4.14"/>
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    <dbReference type="CTD" id="178584"/>
    <dbReference type="WormBase" id="C05E4.14a">
        <property type="protein sequence ID" value="CE45683"/>
        <property type="gene ID" value="WBGene00005228"/>
        <property type="gene designation" value="srh-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1490323_0_0_1"/>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005228">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="E4MVC8">
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    </dbReference>
    <dbReference type="InterPro" id="IPR019422">
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    </dbReference>
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        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47405">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C05E4.14a"/>
        </source>
    </evidence>
    <sequence length="181" mass="20163" checksum="6D9FD18330686A51" modified="2011-02-08" version="1">MMETSYDRRALVLWFRRCSEAPNCGGAPAGKADFYGNIVGVGTCDIALDFLKSSHFFEVLAKSPLALLHFHFCGKCSGIVTYKALKVSRASAAVRKIQKNIFMSLVVSTITHLGLLFIPLATFFMLSLLVPEWSKSSIVKYTSDFMVIMIQQHGAVSAVTMFLTNNLLRRTAKQLFYTEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-03-08" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>E7EM33</accession>
    <name>E7EM33_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2 4" type="primary">unc-43</name>
        <name evidence="2" type="ORF">CELE_K11E8.1</name>
        <name evidence="4" type="ORF">K11E8.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBY85348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255483.1">
        <property type="nucleotide sequence ID" value="NM_001268554.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E7EM33"/>
    <dbReference type="SMR" id="E7EM33"/>
    <dbReference type="IntAct" id="E7EM33">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="E7EM33"/>
    <dbReference type="GeneID" id="177921"/>
    <dbReference type="AGR" id="WB:WBGene00006779"/>
    <dbReference type="CTD" id="177921"/>
    <dbReference type="WormBase" id="K11E8.1q">
        <property type="protein sequence ID" value="CE45591"/>
        <property type="gene ID" value="WBGene00006779"/>
        <property type="gene designation" value="unc-43"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_71_2_1"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006779">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E7EM33">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Calcium/calmodulin-dependent protein kinase II association-domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBY85348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K11E8.1q"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="E7EM33"/>
        </source>
    </evidence>
    <sequence length="103" mass="11878" checksum="DF97EAD32ACBC4D6" modified="2011-03-08" version="1">MTCFEPEALGNLIEGIEFHRFYFDGNRKNQVHTTMLNPNVHIIGEDAACVAYVKLTQFLDRNGEAHTRQSQESRVWSKKQGRWVCVHVHRSTQPSTNTTVSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-03-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>E7EM35</accession>
    <name>E7EM35_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3149 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C51E3.10</name>
        <name evidence="2" type="ORF">CELE_C51E3.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBY85344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256191.1">
        <property type="nucleotide sequence ID" value="NM_001269262.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E7EM35"/>
    <dbReference type="GeneID" id="3564871"/>
    <dbReference type="AGR" id="WB:WBGene00008255"/>
    <dbReference type="CTD" id="3564871"/>
    <dbReference type="WormBase" id="C51E3.10c">
        <property type="protein sequence ID" value="CE45694"/>
        <property type="gene ID" value="WBGene00008255"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3261025_0_0_1"/>
    <dbReference type="OrthoDB" id="10404907at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E7EM35">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBY85344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C51E3.10c"/>
        </source>
    </evidence>
    <sequence length="42" mass="4837" checksum="B0165E4600A52109" modified="2011-03-08" version="1">MALLFVFIGFNLAVTVFGYTLFWNLFPKDRMGAIQRQNGEPI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-04-07" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>F5GUE5-2</accession>
    <name>DAF14_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Smad-related protein daf-14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Abnormal dauer formation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">daf-14</name>
        <name evidence="5" type="ORF">F01G10.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2000" name="Dev. Biol." volume="217" first="192" last="204">
            <title>Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation.</title>
            <authorList>
                <person name="Inoue T."/>
                <person name="Thomas J.H."/>
            </authorList>
            <dbReference type="PubMed" id="10625546"/>
            <dbReference type="DOI" id="10.1006/dbio.1999.9545"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 236-GLN--SER-331; GLY-286 AND 302-TRP--SER-331</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2010" name="Development" volume="137" first="477" last="485">
            <title>Antagonistic Smad transcription factors control the dauer/non-dauer switch in C. elegans.</title>
            <authorList>
                <person name="Park D."/>
                <person name="Estevez A."/>
                <person name="Riddle D.L."/>
            </authorList>
            <dbReference type="PubMed" id="20081192"/>
            <dbReference type="DOI" id="10.1242/dev.043752"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH DAF-8 AND DAF-3</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>F5GUE5-1</id>
            <name evidence="5">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>F5GUE5-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_060999"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255476.1">
        <property type="nucleotide sequence ID" value="NM_001268547.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F01G10.8a">
        <property type="protein sequence ID" value="CE29090"/>
        <property type="gene ID" value="WBGene00000910"/>
        <property type="gene designation" value="daf-14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAF03892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F01G10.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F01G10.8b"/>
        </source>
    </evidence>
    <sequence length="287" mass="32740" checksum="96D6A70DC721F30D" modified="2011-06-28" version="1">MYPDQVHLPASINNPNMPINDWLEDAPMPDCYNVPSTSTDENNDPFPFSNISSQSSLKPKTPEKAVVEVRPTGNEMLDPEPKYPKEEKPWCTIFYYELTVRLGKAFEAKVPTITIDGATGASDECRMSLTSQPSSRNSKSSQIRNTVGAGIQLAYENGELWLTVLTDQIVFVQCPFLNQTLNKPLKYVFRLQNKGDQKRMKIFDKEQFEQEKTLALGPLTEKEVADERMRIFSNIRVSFCKGFGETYSRLKVVNLPCWIEIILHEPADEYDTVFRINNERPEIGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G4S8L3</accession>
    <name>G4S8L3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F42A9.6</name>
        <name evidence="2 4" type="ORF">F42A9.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD67668.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4S8L3"/>
    <dbReference type="AGR" id="WB:WBGene00018335"/>
    <dbReference type="WormBase" id="F42A9.6a">
        <property type="protein sequence ID" value="CE49658"/>
        <property type="gene ID" value="WBGene00018335"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2294202_0_0_1"/>
    <dbReference type="OrthoDB" id="5822308at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018335">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G4S8L3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD67668.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F42A9.6a"/>
        </source>
    </evidence>
    <sequence length="123" mass="14397" checksum="7ED1B8D90A2350FF" modified="2014-06-11" version="3">MLPFYLYVLFTIFYLLFLGGYFFFVNIFYKELVKQALGDHSDSVSFIWHFADIMLIMLHAWALSVTSKCRKYFRWVAEGGQKENPKGRLETSNTFEQSNCSMLMVELPTTSTAPRHESKPDIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-07-31" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>G5EC32-2</accession>
    <name>SRBS1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform c of Sorbin and SH3 domain-containing protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">sorb-1</name>
        <name evidence="4" type="ORF">Y45F10D.13</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2017" name="Mol. Biol. Cell" volume="28" first="3621" last="3633">
            <title>Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes.</title>
            <authorList>
                <person name="Loveless T."/>
                <person name="Qadota H."/>
                <person name="Benian G.M."/>
                <person name="Hardin J."/>
            </authorList>
            <dbReference type="PubMed" id="28978740"/>
            <dbReference type="DOI" id="10.1091/mbc.E16-06-0455"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH DEB-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 461-TRP--HIS-1005</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EC32-2</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060226"/>
        </isoform>
        <isoform>
            <id>G5EC32-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255756.1">
        <property type="nucleotide sequence ID" value="NM_001268827.5"/>
    </dbReference>
    <dbReference type="WormBase" id="Y45F10D.13c">
        <property type="protein sequence ID" value="CE39436"/>
        <property type="gene ID" value="WBGene00012891"/>
        <property type="gene designation" value="sorb-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="28978740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y45F10D.13a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y45F10D.13c"/>
        </source>
    </evidence>
    <sequence length="473" mass="54867" checksum="D20A611556410173" modified="2011-12-14" version="1">MCDLPKKDVEFKEIDAIYENMKIKNSQRQRSQNSLDLIRITNNLDETTKSLNLYLQQIDATWKRSKSQPIMKGPNDQYNNQERVKQSNEEELLRLKAEKLAEELRKEKERKHSFIPSSAPSLQNNMDRLNSLLYDFSSDIQEPAHRDYTPQPVMTATAVYKFEPRSARELPLNRGDIIRIIREVDGYWMEGERNGRSGIFPTSYVQINTGNQGDSQKMRAIYPFTARSDTELSLKRGEIITRRRQIDSNWLEGSNQIGIVGIFPASYVEPIEQVEQHIPTIVPNRPKTPKIEDQVYNQVYKPNETVIMQSNQGYYDKAAVVPNNKVRFDLPSGSDSNLQMSLNPHQNQFPPTHTQTSTQQPSNYGMKKIEYEREKVVEEVPPMHMDQYRKLNDEPKNPKKDTNILMNAASLIPKGSEMYRAVYPYQPQKEDELQLYTNDIIFVVEKCDDGWFIGTSLRTGDFGIFPGNYVKRH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-10-14" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>G5EDA5-2</accession>
    <name>KSRB_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Kinase suppressor of Ras B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ksr-2</name>
        <name evidence="4" type="ORF">F58D5.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2002" name="Curr. Biol." volume="12" first="427" last="433">
            <title>C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation.</title>
            <authorList>
                <person name="Ohmachi M."/>
                <person name="Rocheleau C.E."/>
                <person name="Church D."/>
                <person name="Lambie E."/>
                <person name="Schedl T."/>
                <person name="Sundaram M.V."/>
            </authorList>
            <dbReference type="PubMed" id="11882296"/>
            <dbReference type="DOI" id="10.1016/S0960-9822(02)00690-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Development" volume="140" first="3486" last="3495">
            <title>The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans.</title>
            <authorList>
                <person name="Masoudi N."/>
                <person name="Fancsalszky L."/>
                <person name="Pourkarimi E."/>
                <person name="Vellai T."/>
                <person name="Alexa A."/>
                <person name="Remenyi A."/>
                <person name="Gartner A."/>
                <person name="Mehta A."/>
                <person name="Takacs-Vellai K."/>
            </authorList>
            <dbReference type="PubMed" id="23900546"/>
            <dbReference type="DOI" id="10.1242/dev.094011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH NDK-1</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="Genetics" volume="202" first="45" last="59">
            <title>Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling.</title>
            <authorList>
                <person name="Yin Y."/>
                <person name="Donlevy S."/>
                <person name="Smolikove S."/>
            </authorList>
            <dbReference type="PubMed" id="26510792"/>
            <dbReference type="DOI" id="10.1534/genetics.115.177295"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EDA5-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_057950 VSP_057951"/>
        </isoform>
        <isoform>
            <id>G5EDA5-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EDA5-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_057949"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021519.1">
        <property type="nucleotide sequence ID" value="NM_001026348.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F58D5.4b">
        <property type="protein sequence ID" value="CE31018"/>
        <property type="gene ID" value="WBGene00002240"/>
        <property type="gene designation" value="ksr-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAL79358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F58D5.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F58D5.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F58D5.4c"/>
        </source>
    </evidence>
    <sequence length="510" mass="58534" checksum="A6172F792E654D6E" modified="2011-12-14" version="1">MSDEKKKKRYSVLTTSSFSSWRRSSTSGSISQSSRTTSKTTTSSSVTSSNPINAPPPTATSSSSVLPSTSSEPPPPASAPPRISIYHKMVPSKSKFRQCDVCEHIFIFDFVRKQHLDDVYACNVCGIRVHKGCLDRVKNDCKITTQYMGGILENAVIQKNVHKTRKLISMTTSTLDDVTTFNSEINEEMDEETVLMTWEDVTIKLTDVDVMTKIGDGRFGSVYFGGYHGNAAVRFVNMNYLSQEDRRADVFATEIVSAYKNSRHDHIALFYGYVSDPVTNTYAIVTNFYQHNTLYHRIHEQLSEDFDQSWTFQISLQICQAMSYLHKKKILHRDLRTKNILLDNPNRVVVTDFALMKLERLENPRRNCTLLIPNHWIDYLSPEIAGNLMIDWRGDVLFQHELPFSQESDVYSFGTIFFELLLRRMPTGCDSWDQKLYAKMCGQKAALQRLDAQLQKIDGKLHELLLECWSSQPEKRPSFQQIVKRITVQMPRKESNKQKRRSTAHENPLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-10-14" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>G5EDA5-3</accession>
    <name>KSRB_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Kinase suppressor of Ras B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ksr-2</name>
        <name evidence="4" type="ORF">F58D5.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2002" name="Curr. Biol." volume="12" first="427" last="433">
            <title>C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation.</title>
            <authorList>
                <person name="Ohmachi M."/>
                <person name="Rocheleau C.E."/>
                <person name="Church D."/>
                <person name="Lambie E."/>
                <person name="Schedl T."/>
                <person name="Sundaram M.V."/>
            </authorList>
            <dbReference type="PubMed" id="11882296"/>
            <dbReference type="DOI" id="10.1016/S0960-9822(02)00690-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Development" volume="140" first="3486" last="3495">
            <title>The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans.</title>
            <authorList>
                <person name="Masoudi N."/>
                <person name="Fancsalszky L."/>
                <person name="Pourkarimi E."/>
                <person name="Vellai T."/>
                <person name="Alexa A."/>
                <person name="Remenyi A."/>
                <person name="Gartner A."/>
                <person name="Mehta A."/>
                <person name="Takacs-Vellai K."/>
            </authorList>
            <dbReference type="PubMed" id="23900546"/>
            <dbReference type="DOI" id="10.1242/dev.094011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH NDK-1</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="Genetics" volume="202" first="45" last="59">
            <title>Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling.</title>
            <authorList>
                <person name="Yin Y."/>
                <person name="Donlevy S."/>
                <person name="Smolikove S."/>
            </authorList>
            <dbReference type="PubMed" id="26510792"/>
            <dbReference type="DOI" id="10.1534/genetics.115.177295"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EDA5-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_057951 VSP_057950"/>
        </isoform>
        <isoform>
            <id>G5EDA5-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_057949"/>
        </isoform>
        <isoform>
            <id>G5EDA5-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001129779.1">
        <property type="nucleotide sequence ID" value="NM_001136307.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F58D5.4c">
        <property type="protein sequence ID" value="CE42786"/>
        <property type="gene ID" value="WBGene00002240"/>
        <property type="gene designation" value="ksr-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAL79358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F58D5.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F58D5.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F58D5.4c"/>
        </source>
    </evidence>
    <sequence length="458" mass="53044" checksum="C8D388F5C1073E77" modified="2011-12-14" version="1">MVPSKSKFRQCDVCEHIFIFDFVRKQHLDDVYACNVCGIRVHKGCLDRVKNDCKITTQYMGGILENAVIQSNKKQWEKPTTASISKSLTTSPTCSTSTTMSPAGVEKNVHKTRKLISMTTSTLDDVTTFNSEINEEMDEETVLMTWEDVTIKLTDVDVMTKIGDGRFGSVYFGGYHGNAAVRFVNMNYLSQEDRRADVFATEIVSAYKNSRHDHIALFYGYVSDPVTNTYAIVTNFYQHNTLYHRIHEQLSEDFDQSWTFQISLQICQAMSYLHKKKILHRDLRTKNILLDNPNRVVVTDFALMKLERLENPRRNCTLLIPNHWIDYLSPEIAGNLMIDWRGDVLFQHELPFSQESDVYSFGTIFFELLLRRMPTGCDSWDQKLYAKMCGQKAALQRLDAQLQKIDGKLHELLLECWSSQPEKRPSFQQIVKRITVQMPRKESNKQKRRSTAHENPLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-06-28" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>G5EDW5-2</accession>
    <name>ADM2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Disintegrin and metalloproteinase domain-containing protein adm-2</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adm-2</name>
        <name evidence="4" type="ORF">C04A11.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="PLoS Genet." volume="18" first="e1010249" last="e1010249">
            <title>An unexpected role for the conserved ADAM-family metalloprotease ADM-2 in Caenorhabditis elegans molting.</title>
            <authorList>
                <person name="Joseph B.B."/>
                <person name="Edeen P.T."/>
                <person name="Meadows S."/>
                <person name="Binti S."/>
                <person name="Fay D.S."/>
            </authorList>
            <dbReference type="PubMed" id="35639786"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1010249"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 312-HIS--HIS-322 AND 494-TRP--LYS-952</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EDW5-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EDW5-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061940 VSP_061941"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001355451.1">
        <property type="nucleotide sequence ID" value="NM_001368538.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C04A11.4b">
        <property type="protein sequence ID" value="CE52805"/>
        <property type="gene ID" value="WBGene00000074"/>
        <property type="gene designation" value="adm-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q61072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C04A11.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C04A11.4b"/>
        </source>
    </evidence>
    <sequence length="929" mass="103060" checksum="CB10AF72BBBCEB65" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY12</accession>
    <name>G8JY12_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">npr-8</name>
        <name evidence="15" type="ORF">C56G3.1</name>
        <name evidence="13" type="ORF">CELE_C56G3.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741834.1">
        <property type="nucleotide sequence ID" value="NM_171723.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY12"/>
    <dbReference type="SMR" id="G8JY12"/>
    <dbReference type="GeneID" id="183869"/>
    <dbReference type="AGR" id="WB:WBGene00016984"/>
    <dbReference type="CTD" id="183869"/>
    <dbReference type="WormBase" id="C56G3.1b">
        <property type="protein sequence ID" value="CE30923"/>
        <property type="gene ID" value="WBGene00016984"/>
        <property type="gene designation" value="npr-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579001_0_0_1"/>
    <dbReference type="OMA" id="NTNFRHE"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="PhylomeDB" id="G8JY12"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016984">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY12">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR NPR-8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="87"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD63511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="C56G3.1b"/>
        </source>
    </evidence>
    <sequence length="510" mass="58605" checksum="3CF2EA22BE81CD92" modified="2012-01-25" version="1">MDFINELFFTDTDIEDLGMIMEVKDIDNYCDRGISPNASNYLTYPFDGLCLQKFFYQLQTSLRRFTPYEEIIYTTVYIIISVAAVIGNGLVIMAVVRKKTMRTNRNVLILNLALSNLILAITNIPFLWLPSIDFEFPYSRFFCKFANVLPGSNIYCSTLTISVMAIDRYYSVKKLKIASNRKQCFHAVLVSLAIWIVSFILSLPLLLYYETSMLYVMREIRVVDQSGQEVIRSYGWRQCRLVSAGRLPDITQSIQLLMSILQVAFLYIVPLFVLSIFNVKLTRFLKTNANKMSKTRAPPKRFDRSDSHHNSLKNNNNHTSSLRSPSMPSIRSSITERNKTNQRTNRTTSLLIAMAGSYAALWFPFTLITFLIDFELIINQDYVNLVERIDQTCKMVSMLSICVNPFLYGFLNTNFRHEFSDIYYRYIRCETKSQPAGRFHHDVSSIAHHRQDSVYNDEATLLTTGRQSNGKDGSSSPIGFRSSVRVCSGQTKMIGDRIVLDDDIEKDSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY22</accession>
    <name>G8JY22_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">abhd-3.2</name>
        <name evidence="5" type="ORF">C44C1.5</name>
        <name evidence="3" type="ORF">CELE_C44C1.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024459.1">
        <property type="nucleotide sequence ID" value="NM_001029288.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY22"/>
    <dbReference type="SMR" id="G8JY22"/>
    <dbReference type="PeptideAtlas" id="G8JY22"/>
    <dbReference type="GeneID" id="180450"/>
    <dbReference type="AGR" id="WB:WBGene00016644"/>
    <dbReference type="CTD" id="180450"/>
    <dbReference type="WormBase" id="C44C1.5b">
        <property type="protein sequence ID" value="CE33918"/>
        <property type="gene ID" value="WBGene00016644"/>
        <property type="gene designation" value="abhd-3.2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032487_4_0_1"/>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016644">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY22">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="108"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD63975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C44C1.5b"/>
        </source>
    </evidence>
    <sequence length="250" mass="27990" checksum="B9CFB222191457C4" modified="2012-01-25" version="1">MVLPLILTLVIVAPIFLWMYSWYISAIPKHYVKPGTKLQKKVHSNLRILEQKYHPSWWCPFGTTQTVVRQIFRDCPSLPFTREIVEFDDGGAAGIDWLIPEGADDTTPIVVFLPGITGSTHDSSYVLHPVKEARDKGWKCVVVNPRGLGGVKLRTTRTYNAATPHDFAFIAKMINERYPDAKKLGCGFSMGGMILWNYLAMTGENADLDGGMIVSSPWDPLVASDSIECFIPQLIFNSFIAKNLVDMVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY24</accession>
    <name>G8JY24_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">pcm-1</name>
        <name evidence="13" type="ORF">C10F3.5</name>
        <name evidence="11" type="ORF">CELE_C10F3.5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="10"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD64128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122844.1">
        <property type="nucleotide sequence ID" value="NM_001129372.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY24"/>
    <dbReference type="SMR" id="G8JY24"/>
    <dbReference type="PeptideAtlas" id="G8JY24"/>
    <dbReference type="GeneID" id="178981"/>
    <dbReference type="AGR" id="WB:WBGene00003954"/>
    <dbReference type="CTD" id="178981"/>
    <dbReference type="WormBase" id="C10F3.5b">
        <property type="protein sequence ID" value="CE41195"/>
        <property type="gene ID" value="WBGene00003954"/>
        <property type="gene designation" value="pcm-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003954">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY24">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033555">
        <property type="term" value="P:multicellular organismal response to stress"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000235">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD64128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C10F3.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="G8JY24"/>
        </source>
    </evidence>
    <sequence length="219" mass="24144" checksum="41B4DFA26BBC18B1" modified="2012-01-25" version="1">MAWRSSGSTNSELIDNLRNNRVFASQRAYDAMKSVDRGDFAPRAPYEDAPQRIGYNATHAAALDYLQNHLVAGAKALDVGSGSGYLTVCMAMMVGRNGTVVGIEHMPQLVELSEKNIRKHHSEQLERGNVIIIEGDGRQGFAEKAPYNAIHVGAASKGVPKALTDQLAEGGRMMIPVEQVDGNQVFMQIDKINGKIEQKIVEHVIYVPLTSREEQWNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY28</accession>
    <name>G8JY28_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sex-determining transformer protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">tra-2</name>
        <name evidence="4" type="ORF">C15F1.3</name>
        <name evidence="2" type="ORF">CELE_C15F1.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD64620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367508.1">
        <property type="nucleotide sequence ID" value="NM_001381483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY28"/>
    <dbReference type="SMR" id="G8JY28"/>
    <dbReference type="GeneID" id="174137"/>
    <dbReference type="AGR" id="WB:WBGene00006605"/>
    <dbReference type="CTD" id="174137"/>
    <dbReference type="WormBase" id="C15F1.3c">
        <property type="protein sequence ID" value="CE43762"/>
        <property type="gene ID" value="WBGene00006605"/>
        <property type="gene designation" value="tra-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_714196_0_0_1"/>
    <dbReference type="OrthoDB" id="5819423at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006605">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY28">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008585">
        <property type="term" value="P:female gonad development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040021">
        <property type="term" value="P:hermaphrodite germ-line sex determination"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042001">
        <property type="term" value="P:hermaphrodite somatic sex determination"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048599">
        <property type="term" value="P:oocyte development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030716">
        <property type="term" value="P:oocyte fate determination"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048601">
        <property type="term" value="P:oocyte morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032848">
        <property type="entry name" value="Ce-Tra-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39365">
        <property type="entry name" value="MX REGION OF TRA-2 RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39365:SF2">
        <property type="entry name" value="MX REGION OF TRA-2 RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD64620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C15F1.3c"/>
        </source>
    </evidence>
    <sequence length="387" mass="44562" checksum="320ACB21F322928A" modified="2012-01-25" version="1">MFESEVRHYLHRDLRGSTTAVRVYNLVQKQRLASSLDEPQVELDEFSIKRSSPPCRYYAPPPKYSCKKRSRSSDEDEDSDPNQPGPSNRRSPKTGNKRVRGNGDNTELYIPNRYELIVSGKSVGGNTSAAWNGPGSTLEQNMNALEECFELGVDEYDFDEHDGDEGCELVQDMLDRERNLMNKRSTAQRRESRNIEKMKKSQENLDKEKSEEKISESKKNQDDSIESPNLPGTPANLPVDEPLPPVGRLYIVEHVLPEEYRRDPLTEPPSMEDCIRAHSDPNLPPHPRADQYPASFTRPMVEYCEDIYWTHRTGQLPPGLQVPRRPYDYYHITERTPPPEDLNWVPPAESPPIPIPQQAFDLLEERRRNHREQQDEAREGDLSDPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY31</accession>
    <name>G8JY31_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_K07C11.7</name>
        <name evidence="3 5" type="ORF">K07C11.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0046 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD64762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY31"/>
    <dbReference type="SMR" id="G8JY31"/>
    <dbReference type="PeptideAtlas" id="G8JY31"/>
    <dbReference type="AGR" id="WB:WBGene00019479"/>
    <dbReference type="WormBase" id="K07C11.7b">
        <property type="protein sequence ID" value="CE33142"/>
        <property type="gene ID" value="WBGene00019479"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_1_1_1"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019479">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY31">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024201">
        <property type="entry name" value="Calcineurin-like_Pesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF19">
        <property type="entry name" value="UPF0046 PROTEIN K07C11.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035808">
        <property type="entry name" value="Pdiesterase_Brain_239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD64762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K07C11.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="G8JY31"/>
        </source>
    </evidence>
    <sequence length="271" mass="30670" checksum="7509F7CE6DF99363" modified="2012-01-25" version="1">MEAKSQRIDPDAENELWDSIKHTKVQNIVEKNAIGEINSPPTDGTPYLKVVCISDTHEQLHNVTVPDGDVLIHAGDFTNNGKREELIKFNEEMTRFPHKYKLVVAGNHELGFDHDENQGERQDADKGLGTEDGYNILTNVTYLQDKGVTIDGVTFFGSSYHPLRGFPFYRNRAEQLAECWKAVPNDTNVLITHTPPLGYLDQFGDERWGCRDLLKTVERIQPAYHIFGHVHEQHGVLSNGNTTFINAAQCNKGNQIQTRPIVFYIPKKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY36</accession>
    <name>G8JY36_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Protein kinase C</fullName>
            <ecNumber evidence="2 14">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">pkc-2</name>
        <name evidence="25" type="ORF">CELE_E01H11.1</name>
        <name evidence="27" type="ORF">E01H11.1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="18">Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2 14"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD65291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123122.1">
        <property type="nucleotide sequence ID" value="NM_001129650.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY36"/>
    <dbReference type="SMR" id="G8JY36"/>
    <dbReference type="PeptideAtlas" id="G8JY36"/>
    <dbReference type="GeneID" id="181166"/>
    <dbReference type="AGR" id="WB:WBGene00004033"/>
    <dbReference type="CTD" id="181166"/>
    <dbReference type="WormBase" id="E01H11.1d">
        <property type="protein sequence ID" value="CE41783"/>
        <property type="gene ID" value="WBGene00004033"/>
        <property type="gene designation" value="pkc-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_54_2_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004033">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY36">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004698">
        <property type="term" value="F:calcium,diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20833">
        <property type="entry name" value="C1_cPKC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20836">
        <property type="entry name" value="C1_cPKC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04026">
        <property type="entry name" value="C2_PKC_alpha_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05587">
        <property type="entry name" value="STKc_cPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000012">
        <property type="entry name" value="Kinase C alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000023">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000006">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000031">
        <property type="entry name" value="Protein kinase C alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR014375">
        <property type="entry name" value="Protein_kinase_C_a/b/g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000550">
        <property type="entry name" value="PKC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
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    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13 14 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 14 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="23">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="23">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="205"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="393"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="24">
        <location>
            <begin position="655"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="240"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="18">
        <location>
            <position position="295"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="296"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="300"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="302"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
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        <location>
            <begin position="399"/>
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        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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        <source>
            <dbReference type="PROSITE" id="PS50081"/>
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        <source>
            <dbReference type="PROSITE" id="PS51285"/>
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        <source>
            <dbReference type="EMBL" id="CCD65291.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="E01H11.1d"/>
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    <evidence type="ECO:0007829" key="28">
        <source>
            <dbReference type="PeptideAtlas" id="G8JY36"/>
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    <sequence length="725" mass="82408" checksum="9EA97D05B44201F3" modified="2012-01-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY39</accession>
    <name>G8JY39_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </submittedName>
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        <name evidence="7 9" type="primary">acl-6</name>
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        <name evidence="9" type="ORF">F08F3.2</name>
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    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
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        <property type="protein sequence ID" value="CCD65591.1"/>
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        <property type="nucleotide sequence ID" value="NM_001028599.5"/>
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        <property type="protein sequence ID" value="CE35851"/>
        <property type="gene ID" value="WBGene00017261"/>
        <property type="gene designation" value="acl-6"/>
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        <property type="component" value="Chromosome V"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
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        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
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        <property type="entry name" value="GPAT_PlsB"/>
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        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
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        <property type="entry name" value="BCDNA.GH07066"/>
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            <end position="134"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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        <source>
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        <source>
            <dbReference type="PeptideAtlas" id="G8JY39"/>
        </source>
    </evidence>
    <sequence length="558" mass="63048" checksum="D30A5ECE71BBD636" modified="2012-01-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY43</accession>
    <name>G8JY43_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">T-complex protein 1 subunit zeta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cct-6</name>
        <name evidence="8" type="ORF">CELE_F01F1.8</name>
        <name evidence="10" type="ORF">F01F1.8</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD65991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741154.1">
        <property type="nucleotide sequence ID" value="NM_171136.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY43"/>
    <dbReference type="SMR" id="G8JY43"/>
    <dbReference type="PeptideAtlas" id="G8JY43"/>
    <dbReference type="GeneID" id="175819"/>
    <dbReference type="AGR" id="WB:WBGene00000381"/>
    <dbReference type="CTD" id="175819"/>
    <dbReference type="WormBase" id="F01F1.8b">
        <property type="protein sequence ID" value="CE30647"/>
        <property type="gene ID" value="WBGene00000381"/>
        <property type="gene designation" value="cct-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_3_1_1"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000381">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY43">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD65991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F01F1.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="G8JY43"/>
        </source>
    </evidence>
    <sequence length="429" mass="47671" checksum="08003EB3EBE49AB0" modified="2012-01-25" version="1">MSSIQCLNPKAELARHAAALELNISGARGLQDVMRSNLGPKGTLKMLVSGAGDIKLTKDGNVLLHEMAIQHPTASMIAKASTAQDDVTGDGTTSTVLLIGELLKQAESLVLEGLHPRIVTEGFEWANTKTLELLEKFKKEAPVERDLLVEVCRTALRTKLHQKLADHITECVVDAVLAIRRDGEEPDLHMVEKMEMHHDSDMDTTLVRGLVLDHGARHPDMPRHVKDAYILTCNVSLEYEKTEVNSGLFYKTAKEREALLAAEREFITRRVHKIIELKKKVIDNSPDGKNKGFVVINQKGIDPPSLDLLASEGILALRRAKRRNMERLQLAVGGEAVNSVDDLTPEDLGWAGLVYEHSLGEEKYTFIEECRAPKSVTLLIKGPNKHTITQIKDAIHDGLRAVFNTIVDSCSPWSCCFRNCCLRDVEKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY79</accession>
    <name>G8JY79_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">mlc-3</name>
        <name evidence="5" type="ORF">CELE_F09F7.2</name>
        <name evidence="7" type="ORF">F09F7.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD68382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359961.1">
        <property type="nucleotide sequence ID" value="NM_001372589.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY79"/>
    <dbReference type="SMR" id="G8JY79"/>
    <dbReference type="PeptideAtlas" id="G8JY79"/>
    <dbReference type="GeneID" id="175768"/>
    <dbReference type="AGR" id="WB:WBGene00003371"/>
    <dbReference type="CTD" id="175768"/>
    <dbReference type="WormBase" id="F09F7.2b">
        <property type="protein sequence ID" value="CE30652"/>
        <property type="gene ID" value="WBGene00003371"/>
        <property type="gene designation" value="mlc-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2442848_0_0_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003371">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY79">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005863">
        <property type="term" value="C:striated muscle myosin thick filament"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000713">
        <property type="entry name" value="Myosin, essential light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF33">
        <property type="entry name" value="MYOSIN LIGHT CHAIN ALKALI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0518">Myosin</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD68382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F09F7.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="G8JY79"/>
        </source>
    </evidence>
    <sequence length="90" mass="10250" checksum="8B32AEE6B3385E9C" modified="2012-01-25" version="1">MAPPSQDVLKEIFNLYDEELDGKIDGTQVGDVARAAGLKPTQAMVTKAAGQEFKRKGEKRLTFEEWLPMYEQLAKEKVRYFKHLACAFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY82</accession>
    <name>G8JY82_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F25B5.3</name>
        <name evidence="1 3" type="ORF">F25B5.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD68778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY82"/>
    <dbReference type="AGR" id="WB:WBGene00017775"/>
    <dbReference type="WormBase" id="F25B5.3e">
        <property type="protein sequence ID" value="CE30664"/>
        <property type="gene ID" value="WBGene00017775"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3070697_0_0_1"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017775">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY82">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD68778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F25B5.3e"/>
        </source>
    </evidence>
    <sequence length="53" mass="6200" checksum="6C1CA389E6C4A125" modified="2012-01-25" version="1">MSNKVARRLGKCLFVSGRRFESRQSILQLRSVLRESCWLQTVVSVCEHTRNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY85</accession>
    <name>G8JY85_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="4">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">asm-3</name>
        <name evidence="9" type="ORF">CELE_W03G1.7</name>
        <name evidence="11" type="ORF">W03G1.7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="4"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD69085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040997.1">
        <property type="nucleotide sequence ID" value="NM_001047532.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY85"/>
    <dbReference type="SMR" id="G8JY85"/>
    <dbReference type="PeptideAtlas" id="G8JY85"/>
    <dbReference type="GeneID" id="176879"/>
    <dbReference type="AGR" id="WB:WBGene00000213"/>
    <dbReference type="CTD" id="176879"/>
    <dbReference type="WormBase" id="W03G1.7b">
        <property type="protein sequence ID" value="CE39794"/>
        <property type="gene ID" value="WBGene00000213"/>
        <property type="gene designation" value="asm-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014743_3_0_1"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000213">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY85">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF31">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE ASM-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="89"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="486"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD69085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="W03G1.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="G8JY85"/>
        </source>
    </evidence>
    <sequence length="545" mass="62552" checksum="A3CB04786009385F" modified="2012-01-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY94</accession>
    <name>G8JY94_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Intermediate filament protein ifc-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ifc-2</name>
        <name evidence="6" type="ORF">CELE_M6.1</name>
        <name evidence="8" type="ORF">M6.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256975.1">
        <property type="nucleotide sequence ID" value="NM_001270046.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY94"/>
    <dbReference type="SMR" id="G8JY94"/>
    <dbReference type="PeptideAtlas" id="G8JY94"/>
    <dbReference type="GeneID" id="180414"/>
    <dbReference type="KEGG" id="cel:CELE_M6.1"/>
    <dbReference type="AGR" id="WB:WBGene00002056"/>
    <dbReference type="CTD" id="180414"/>
    <dbReference type="WormBase" id="M6.1d">
        <property type="protein sequence ID" value="CE45765"/>
        <property type="gene ID" value="WBGene00002056"/>
        <property type="gene designation" value="ifc-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030212_0_0_1"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="PhylomeDB" id="G8JY94"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002056">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY94">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF1">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="51"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="4">
        <location>
            <begin position="509"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="320"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD69444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="M6.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="G8JY94"/>
        </source>
    </evidence>
    <sequence length="622" mass="70101" checksum="2C60BF55FE97729E" modified="2012-01-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYA2</accession>
    <name>H2KYA2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LIn-26 Related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">lir-1</name>
        <name evidence="1" type="ORF">CELE_F18A1.3</name>
        <name evidence="3" type="ORF">F18A1.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD62038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022096.1">
        <property type="nucleotide sequence ID" value="NM_001026925.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYA2"/>
    <dbReference type="SMR" id="H2KYA2"/>
    <dbReference type="GeneID" id="174240"/>
    <dbReference type="AGR" id="WB:WBGene00003044"/>
    <dbReference type="CTD" id="174240"/>
    <dbReference type="WormBase" id="F18A1.3d">
        <property type="protein sequence ID" value="CE37001"/>
        <property type="gene ID" value="WBGene00003044"/>
        <property type="gene designation" value="lir-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5775637at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003044">
        <property type="expression patterns" value="Expressed in embryo and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYA2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD62038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F18A1.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYA2"/>
        </source>
    </evidence>
    <sequence length="300" mass="34220" checksum="708D4EBF26823C0C" modified="2012-03-21" version="1">MPKFVVIELNDDAATIDLLSYCVKKNFERVSLLTRLEDHPYLRDDQDVVQDDTQSQGTDGMLLQLNDEERQRLMKMISTPGPQTLSMERIQMAPGQGQHILQQHQIPSTSSYTNNSFIYIKSDPQYKDEPQQQSNQFDATVNSVAHGQAGLSTLEMFACNGSPNGGDVLRRKTPSRKAEDSIKATCKVCGHDVMYSPQRTWNLMRHVWIMHQSSKPNQCSICGYSHIKPYVRKHIESQHKHDSNATIIDLKSPELEAEWSQLLDQCFGVTYRKWKHHKEDTQHTGGLLFDDDELRGLCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYA3</accession>
    <name>H2KYA3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ALS/FTD Associated gene homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">alfa-1</name>
        <name evidence="1" type="ORF">CELE_F18A1.6</name>
        <name evidence="3" type="ORF">F18A1.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD62043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_495604.1">
        <property type="nucleotide sequence ID" value="NM_063203.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYA3"/>
    <dbReference type="PeptideAtlas" id="H2KYA3"/>
    <dbReference type="GeneID" id="174236"/>
    <dbReference type="AGR" id="WB:WBGene00017547"/>
    <dbReference type="CTD" id="174236"/>
    <dbReference type="WormBase" id="F18A1.6a">
        <property type="protein sequence ID" value="CE04406"/>
        <property type="gene ID" value="WBGene00017547"/>
        <property type="gene designation" value="alfa-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017547">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYA3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027819">
        <property type="entry name" value="C9orf72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31855">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31855:SF2">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15019">
        <property type="entry name" value="C9orf72-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51835">
        <property type="entry name" value="DENN_C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD62043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F18A1.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYA3"/>
        </source>
    </evidence>
    <sequence length="731" mass="82065" checksum="8785CEA625E64A26" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYA4</accession>
    <name>H2KYA4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">unc-82</name>
        <name evidence="4" type="ORF">B0496.3</name>
        <name evidence="2" type="ORF">CELE_B0496.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD62053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379584.1">
        <property type="nucleotide sequence ID" value="NM_001392329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYA4"/>
    <dbReference type="PeptideAtlas" id="H2KYA4"/>
    <dbReference type="GeneID" id="177514"/>
    <dbReference type="AGR" id="WB:WBGene00006814"/>
    <dbReference type="CTD" id="177514"/>
    <dbReference type="WormBase" id="B0496.3c">
        <property type="protein sequence ID" value="CE44313"/>
        <property type="gene ID" value="WBGene00006814"/>
        <property type="gene designation" value="unc-82"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_957223_0_0_1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006814">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYA4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071688">
        <property type="term" value="P:striated muscle myosin thick filament assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061203">
        <property type="term" value="P:striated muscle paramyosin thick filament assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD62053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="B0496.3c"/>
        </source>
    </evidence>
    <sequence length="291" mass="33519" checksum="0CE6EEF8182BA6FF" modified="2012-03-21" version="1">MNNRFRPTARRVASAMTDADRRNYHRSRSMDRNKVDYEYGSNLLNRLTTPDSHGDYSYVNYHDSSNGRSNITLEKDGQPRSILKNKQSADIEPRVESSYEPSNGVRSHEFLDQLLSMRFILQVFERLRRHLSLEKSVSPQRQVASVGPHSRNIDSTSSALDNPKKKRSLLSFNRRKTSEVRMGADGKLVTNGYDSTPSSRDFKRPSSPIDRIKSLFRKNESSGTGHSDYYNSSRNYTSSNPVSTTREPYVAQYRKYPGSTSRDTSSALNRYSYTPGLTDQRRHWYDDPNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYA6</accession>
    <name>H2KYA6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">unc-82</name>
        <name evidence="11" type="ORF">B0496.3</name>
        <name evidence="9" type="ORF">CELE_B0496.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD62056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359805.1">
        <property type="nucleotide sequence ID" value="NM_001372869.1"/>
    </dbReference>
    <dbReference type="SMR" id="H2KYA6"/>
    <dbReference type="PeptideAtlas" id="H2KYA6"/>
    <dbReference type="GeneID" id="177514"/>
    <dbReference type="AGR" id="WB:WBGene00006814"/>
    <dbReference type="CTD" id="177514"/>
    <dbReference type="WormBase" id="B0496.3g">
        <property type="protein sequence ID" value="CE44297"/>
        <property type="gene ID" value="WBGene00006814"/>
        <property type="gene designation" value="unc-82"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006814">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYA6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071688">
        <property type="term" value="P:striated muscle myosin thick filament assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061203">
        <property type="term" value="P:striated muscle paramyosin thick filament assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd14073">
        <property type="entry name" value="STKc_NUAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000389">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF93">
        <property type="entry name" value="NUAK FAMILY SNF1-LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="58"/>
            <end position="309"/>
        </location>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">Bristol N2</strain>
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    </evidence>
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    </evidence>
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</entry>
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            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="880"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1079"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1104"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1129"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1164"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1174"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1480"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD62061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="B0496.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYA9"/>
        </source>
    </evidence>
    <sequence length="1544" mass="175419" checksum="684351F67F5F7A26" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZE0</accession>
    <name>H2KZE0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">39S ribosomal protein L52, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F48D6.4</name>
        <name evidence="1 3" type="ORF">F48D6.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508723.1">
        <property type="nucleotide sequence ID" value="NM_076322.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZE0"/>
    <dbReference type="PeptideAtlas" id="H2KZE0"/>
    <dbReference type="GeneID" id="180697"/>
    <dbReference type="AGR" id="WB:WBGene00018602"/>
    <dbReference type="CTD" id="180697"/>
    <dbReference type="WormBase" id="F48D6.4c">
        <property type="protein sequence ID" value="CE29328"/>
        <property type="gene ID" value="WBGene00018602"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2335533_0_0_1"/>
    <dbReference type="OrthoDB" id="5839397at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018602">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZE0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD67850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F48D6.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZE0"/>
        </source>
    </evidence>
    <sequence length="96" mass="11191" checksum="0639BCE7B8A75D40" modified="2012-03-21" version="1">MSTPKLVRVAQSAVFNQFMTREAISSATFRPAEPKMMDQPKMNIRIHDESTHLKFGFPKTEKVSNPDDFIQLNCEKLIKEEQDRQCAFLKLTNLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZE2</accession>
    <name>H2KZE2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prion-like-(Q/N-rich)-domain-bearing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C53B7.3</name>
        <name evidence="2" type="ORF">CELE_C53B7.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_509153.1">
        <property type="nucleotide sequence ID" value="NM_076752.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZE2"/>
    <dbReference type="PeptideAtlas" id="H2KZE2"/>
    <dbReference type="GeneID" id="180957"/>
    <dbReference type="AGR" id="WB:WBGene00016894"/>
    <dbReference type="CTD" id="180957"/>
    <dbReference type="WormBase" id="C53B7.3a">
        <property type="protein sequence ID" value="CE06973"/>
        <property type="gene ID" value="WBGene00016894"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855649at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016894">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZE2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36519:SF5">
        <property type="entry name" value="ANTIFREEZE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36519">
        <property type="entry name" value="FIP (FUNGUS-INDUCED PROTEIN) RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0640">Prion</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012926419" evidence="1">
        <location>
            <begin position="16"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD67886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C53B7.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZE2"/>
        </source>
    </evidence>
    <sequence length="243" mass="26299" checksum="6C1E33CB1CA2D16B" modified="2012-03-21" version="1">MQFTILLALFGLASAATYYSSTPSYSNSYRSCSSSYECSSGQTCSNGQCMSSLGYNGGLYSNTYNNNNQYDMNSQYGNQMGTTGSGTYCTTSYSCRSGETCMNNRCQSSYSNNMYNSNSQYSNSGSTCRYSTDCYSGQMCSNGVCVAQYGTSYNNAMYSSSTGNYCTYDNTCGLNQRCVNNMCQSTGSNSMYGSGSSGYNTYGSGNTYGSSNSRCTYNSDCGSNRYCSSGYCTSYVLRQKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZE3</accession>
    <name>H2KZE3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C53B7.3</name>
        <name evidence="2" type="ORF">CELE_C53B7.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123120.1">
        <property type="nucleotide sequence ID" value="NM_001129648.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZE3"/>
    <dbReference type="PeptideAtlas" id="H2KZE3"/>
    <dbReference type="GeneID" id="180957"/>
    <dbReference type="AGR" id="WB:WBGene00016894"/>
    <dbReference type="CTD" id="180957"/>
    <dbReference type="WormBase" id="C53B7.3c">
        <property type="protein sequence ID" value="CE41780"/>
        <property type="gene ID" value="WBGene00016894"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1409984_0_0_1"/>
    <dbReference type="OrthoDB" id="5855649at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016894">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZE3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36519:SF5">
        <property type="entry name" value="ANTIFREEZE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36519">
        <property type="entry name" value="FIP (FUNGUS-INDUCED PROTEIN) RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013288555" evidence="1">
        <location>
            <begin position="16"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD67892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C53B7.3c"/>
        </source>
    </evidence>
    <sequence length="193" mass="21131" checksum="7F5791C9B59B1FE1" modified="2012-03-21" version="1">MQFTILLALFGLASAATYYSSTPSYSNSYRSCSSSYECSSGQTCSNGQCMSSLGYNGGLYSNTYNNNNQYDMNSQYGNQMGTTGSGTYCTTSYSCRSGETCMNNRCQSSYSNNMYNSNSQYSNSGSTCRYSTDCYSGQMCSNGVCVAQYGTSYNNAMYSSSTGSKKHYHNTYPNFTNITIPLSNAHIFSRTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZE7</accession>
    <name>H2KZE7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">kvs-1</name>
        <name evidence="18" type="ORF">C53C9.3</name>
        <name evidence="16" type="ORF">CELE_C53C9.3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024489.1">
        <property type="nucleotide sequence ID" value="NM_001029318.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZE7"/>
    <dbReference type="SMR" id="H2KZE7"/>
    <dbReference type="GeneID" id="183753"/>
    <dbReference type="KEGG" id="cel:CELE_C53C9.3"/>
    <dbReference type="AGR" id="WB:WBGene00002242"/>
    <dbReference type="CTD" id="183753"/>
    <dbReference type="WormBase" id="C53C9.3a">
        <property type="protein sequence ID" value="CE34278"/>
        <property type="gene ID" value="WBGene00002242"/>
        <property type="gene designation" value="kvs-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002242">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZE7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043056">
        <property type="term" value="P:forward locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="project" value="WormBase"/>
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        <property type="term" value="P:mechanosensory behavior"/>
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    </dbReference>
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        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of chemotaxis"/>
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    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CRE-KVS-1 protein"/>
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        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
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        <property type="entry name" value="VG_K_chnl"/>
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        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
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        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
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        <property type="entry name" value="POZ domain"/>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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    <feature type="transmembrane region" description="Helical" evidence="13">
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <end position="402"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="414"/>
            <end position="430"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="442"/>
            <end position="463"/>
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    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="15">
        <location>
            <begin position="73"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="219"/>
            <end position="468"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022448"/>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022826"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD67910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="C53C9.3a"/>
        </source>
    </evidence>
    <sequence length="490" mass="54769" checksum="A8346C293F93D15B" modified="2012-03-21" version="1">MSTERLMYLDLNKGNQIAMVIPSTRKGHAASRDNFGNSNHHGDEIVHRLNNGRRSEIDEVKPDLVSGAGDTVIKLNVGGTSFRIRISSIFARSADEKLSAFAQLNHEQRLQACDAFLMPQEEYYLERSAVLFDSIFKYYISGQLHRPLDVCPTEFATELAYWKINDGLMSNCCWRGYNMSPSLEELVAPKEKKIELHDRSMRSRIHQFCEGDGSLFSTLFTFGSITFVLISVIGLVLGSIHEFQVPIYKKGGKSERISNWSIVENENIIWEPHPIFGYVETVCIIWFTVEFIVRLAVTPNRFQFLVGIMNIVDMIAIIPFYLELGLALFGIDVASLSDIKGALLVVRVLRVLRVVRILKLGRYSSGMRTFALTLKSSARQLGMMGMVLSTGVVFFSTLLYFVEKDEKDTPFTSIPAAFWWAIVTMTTVGYGDYVPVTVPGKLIASGAIISGVLVLALPITIIVDNFMKVSGNVNANIFSSANQRPIDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZE8</accession>
    <name>H2KZE8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">kvs-1</name>
        <name evidence="18" type="ORF">C53C9.3</name>
        <name evidence="16" type="ORF">CELE_C53C9.3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001361979.1">
        <property type="nucleotide sequence ID" value="NM_001375071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZE8"/>
    <dbReference type="SMR" id="H2KZE8"/>
    <dbReference type="GeneID" id="183753"/>
    <dbReference type="AGR" id="WB:WBGene00002242"/>
    <dbReference type="CTD" id="183753"/>
    <dbReference type="WormBase" id="C53C9.3c">
        <property type="protein sequence ID" value="CE36283"/>
        <property type="gene ID" value="WBGene00002242"/>
        <property type="gene designation" value="kvs-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011722_4_1_1"/>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002242">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZE8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043056">
        <property type="term" value="P:forward locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="P:mechanosensory behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050920">
        <property type="term" value="P:regulation of chemotaxis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRE-KVS-1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF262">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="15">
        <location>
            <begin position="73"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="219"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD67912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="C53C9.3c"/>
        </source>
    </evidence>
    <sequence length="477" mass="53428" checksum="336CCDCF6D610C22" modified="2012-03-21" version="1">MSTERLMYLDLNKGNQIAMVIPSTRKGHAASRDNFGNSNHHGDEIVHRLNNGRRSEIDEVKPDLVSGAGDTVIKLNVGGTSFRIRISSIFARSADEKLSAFAQLNHEQRLQACDAFLMPQEEYYLERSAVLFDSIFKYYISGQLHRPLDVCPTEFATELAYWKINDGLMSNCCWRGYNMSPSLEELVAPKEKKIELHDRSMRSRIHQFCEGDGSLFSTLFTFGSITFVLISVIGLVLGSIHEFQVPIYKKGGKSERISNWSIVENENIIWEPHPIFGYVETVCIIWFTVEFIVRLAVTPNRFQFLVGIMNIVDMIAIIPFYLELGLALFGIDVASLSDIKGALLVVRVLRVLRVVRILKLGRYSSGMRTFALTLKSSARQLGMMGMVLSTGVVFFSTLLYFVEKDEKDTPFTSIPAAFWWAIVTMTTVGYGDYVPVTVPGKLIASGAIISGVLVLALPITIIVDNFMKVSGNIDTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>J3JZZ7</accession>
    <name>J3JZZ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">zim-1</name>
        <name evidence="3" type="ORF">CELE_T07G12.6</name>
        <name evidence="5" type="ORF">T07G12.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAD18876.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263777.1">
        <property type="nucleotide sequence ID" value="NM_001276848.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="J3JZZ7"/>
    <dbReference type="SMR" id="J3JZZ7"/>
    <dbReference type="GeneID" id="3565259"/>
    <dbReference type="AGR" id="WB:WBGene00011597"/>
    <dbReference type="CTD" id="3565259"/>
    <dbReference type="WormBase" id="T07G12.6d">
        <property type="protein sequence ID" value="CE35614"/>
        <property type="gene ID" value="WBGene00011597"/>
        <property type="gene designation" value="zim-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007005_0_0_1"/>
    <dbReference type="OrthoDB" id="5865697at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011597">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="J3JZZ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053360">
        <property type="entry name" value="Zinc_finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36945:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36945">
        <property type="entry name" value="HIGH INCIDENCE OF MALES (INCREASED X CHROMOSOME LOSS)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD18876.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T07G12.6d"/>
        </source>
    </evidence>
    <sequence length="218" mass="25378" checksum="FB5286C643A41015" modified="2012-10-03" version="1">MGEFQYNFDDEDTVLIGNYEEVGTEIDEADEQHNEENSEDDEEDESPIPSKKRVSFAVPLVQSRSKQKDEMNKVHIIKCHFDKCNKSYNWRKKYGKLRLVDHAFTHVPHLKMKCNFCDYMCKGIRNIRLHHKKSHPDEQLTGFGIKSVVRTSKKGKDLAKVWDECFKKNRVLQHGSGTDSNLLHFSRQDKGSKRSQKSMDSGAKQKLDEARDEDVKPF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-06-20" modified="2026-01-28" version="160" xmlns="https://uniprot.org/uniprot">
    <accession>O16452-2</accession>
    <name>NHX3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Probable Na(+)/H(+) antiporter nhx-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Na(+)-H(+) exchanger protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nhx-3</name>
        <name type="ORF">C54F6.13</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="J. Biol. Chem." volume="277" first="29036" last="29044">
            <title>The NHX family of Na+-H+ exchangers in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Nehrke K."/>
                <person name="Melvin J.E."/>
            </authorList>
            <dbReference type="PubMed" id="12021279"/>
            <dbReference type="DOI" id="10.1074/jbc.M203200200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O16452-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O16452-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_015557"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001023736.1">
        <property type="nucleotide sequence ID" value="NM_001028565.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C54F6.13b">
        <property type="protein sequence ID" value="CE08985"/>
        <property type="gene ID" value="WBGene00003731"/>
        <property type="gene designation" value="nhx-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="651" mass="73382" checksum="635CC8143F6A3FCB" modified="2003-03-28" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-12-01" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>P28191-2</accession>
    <name>PTP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Tyrosine-protein phosphatase 1</fullName>
            <ecNumber>3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Protein-tyrosine phosphatase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ptp-1</name>
        <name type="ORF">C48D5.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="Immunogenetics" volume="33" first="33" last="41">
            <title>Protein tyrosine phosphatase domains from the protochordate Styela plicata.</title>
            <authorList>
                <person name="Matthews R.J."/>
                <person name="Flores E."/>
                <person name="Thomas M.L."/>
            </authorList>
            <dbReference type="PubMed" id="1704870"/>
            <dbReference type="DOI" id="10.1007/BF00211693"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 844-950</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P28191-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020641 VSP_020644"/>
        </isoform>
        <isoform>
            <id>P28191-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_020642 VSP_020643"/>
        </isoform>
        <isoform>
            <id>P28191-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48"/>
    <dbReference type="RefSeq" id="NP_497733.1">
        <property type="nucleotide sequence ID" value="NM_065332.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C48D5.2b">
        <property type="protein sequence ID" value="CE23603"/>
        <property type="gene ID" value="WBGene00004213"/>
        <property type="gene designation" value="ptp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="624" mass="68783" checksum="04DD488377E2E8B0" modified="2000-05-30" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-12-01" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>P28191-3</accession>
    <name>PTP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Tyrosine-protein phosphatase 1</fullName>
            <ecNumber>3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Protein-tyrosine phosphatase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ptp-1</name>
        <name type="ORF">C48D5.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="Immunogenetics" volume="33" first="33" last="41">
            <title>Protein tyrosine phosphatase domains from the protochordate Styela plicata.</title>
            <authorList>
                <person name="Matthews R.J."/>
                <person name="Flores E."/>
                <person name="Thomas M.L."/>
            </authorList>
            <dbReference type="PubMed" id="1704870"/>
            <dbReference type="DOI" id="10.1007/BF00211693"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 844-950</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P28191-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_020643 VSP_020642"/>
        </isoform>
        <isoform>
            <id>P28191-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P28191-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020644 VSP_020641"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.48"/>
    <dbReference type="RefSeq" id="NP_741112.1">
        <property type="nucleotide sequence ID" value="NM_171099.5"/>
    </dbReference>
    <dbReference type="WormBase" id="C48D5.2c">
        <property type="protein sequence ID" value="CE31450"/>
        <property type="gene ID" value="WBGene00004213"/>
        <property type="gene designation" value="ptp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="589" mass="65125" checksum="1DD1659D73A8BC75" modified="2000-05-30" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-10-01" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>P32742-2</accession>
    <name>IKKE1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform a of Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ikke-1</name>
        <name evidence="3" type="ORF">R107.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2018" name="Nat. Cell Biol." volume="20" first="81" last="91">
            <title>The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Sato M."/>
                <person name="Sato K."/>
                <person name="Tomura K."/>
                <person name="Kosako H."/>
                <person name="Sato K."/>
            </authorList>
            <dbReference type="PubMed" id="29255173"/>
            <dbReference type="DOI" id="10.1038/s41556-017-0008-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>INTERACTION WITH ALLO-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF LYS-49; 126-LEU--CYS-318 AND 131-VAL--ALA-264</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
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<entry dataset="Swiss-Prot" created="1993-10-01" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
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    <name>IKKE1_CAEEL</name>
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            <fullName evidence="3">Isoform c of Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1</fullName>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2018" name="Nat. Cell Biol." volume="20" first="81" last="91">
            <title>The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Sato M."/>
                <person name="Sato K."/>
                <person name="Tomura K."/>
                <person name="Kosako H."/>
                <person name="Sato K."/>
            </authorList>
            <dbReference type="PubMed" id="29255173"/>
            <dbReference type="DOI" id="10.1038/s41556-017-0008-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>INTERACTION WITH ALLO-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF LYS-49; 126-LEU--CYS-318 AND 131-VAL--ALA-264</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P32742-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
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        <isoform>
            <id>P32742-4</id>
            <name evidence="5">d</name>
            <sequence type="described" ref="VSP_004903 VSP_059587"/>
        </isoform>
        <isoform>
            <id>P32742-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_004903"/>
        </isoform>
        <isoform>
            <id>P32742-2</id>
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    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
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<entry dataset="Swiss-Prot" created="1993-10-01" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2018" name="Nat. Cell Biol." volume="20" first="81" last="91">
            <title>The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Sato M."/>
                <person name="Sato K."/>
                <person name="Tomura K."/>
                <person name="Kosako H."/>
                <person name="Sato K."/>
            </authorList>
            <dbReference type="PubMed" id="29255173"/>
            <dbReference type="DOI" id="10.1038/s41556-017-0008-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>INTERACTION WITH ALLO-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF LYS-49; 126-LEU--CYS-318 AND 131-VAL--ALA-264</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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    <evidence type="ECO:0000312" key="4">
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            <dbReference type="WormBase" id="R107.4c"/>
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    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="R107.4d"/>
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<entry dataset="Swiss-Prot" created="1993-10-01" modified="2026-01-28" version="195" xmlns="https://uniprot.org/uniprot">
    <accession>Q03206-2</accession>
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        <alternativeName>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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    <reference key="1">
        <citation type="journal article" date="1993" name="J. Biol. Chem." volume="268" first="320" last="324">
            <title>A new member of the ras superfamily, the rac1 homologue from Caenorhabditis elegans. Cloning and sequence analysis of cDNA, pattern of developmental expression, and biochemical characterization of the protein.</title>
            <authorList>
                <person name="Chen W."/>
                <person name="Lim H.H."/>
                <person name="Lim L."/>
            </authorList>
            <dbReference type="PubMed" id="7677998"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="J. Biol. Chem." volume="271" first="26362" last="26368">
            <title>The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation.</title>
            <authorList>
                <person name="Chen W."/>
                <person name="Chen S."/>
                <person name="Yap S.F."/>
                <person name="Lim L."/>
            </authorList>
            <dbReference type="PubMed" id="8824291"/>
            <dbReference type="DOI" id="10.1074/jbc.271.42.26362"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PAK-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2000" name="Nat. Cell Biol." volume="2" first="131" last="136">
            <title>CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Reddien P.W."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="10707082"/>
            <dbReference type="DOI" id="10.1038/35004000"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Development" volume="133" first="4549" last="4559">
            <title>The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance.</title>
            <authorList>
                <person name="Lucanic M."/>
                <person name="Kiley M."/>
                <person name="Ashcroft N."/>
                <person name="L'Etoile N."/>
                <person name="Cheng H.J."/>
            </authorList>
            <dbReference type="PubMed" id="17050621"/>
            <dbReference type="DOI" id="10.1242/dev.02648"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Curr. Biol." volume="18" first="808" last="813">
            <title>CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.</title>
            <authorList>
                <person name="Quinn C.C."/>
                <person name="Pfeil D.S."/>
                <person name="Wadsworth W.G."/>
            </authorList>
            <dbReference type="PubMed" id="18499456"/>
            <dbReference type="DOI" id="10.1016/j.cub.2008.04.050"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH MIG-10</scope>
        <scope>MUTAGENESIS OF GLY-12 AND GLY-60</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000269" last="E1000269">
            <title>A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.</title>
            <authorList>
                <person name="Lucanic M."/>
                <person name="Cheng H.J."/>
            </authorList>
            <dbReference type="PubMed" id="19023419"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000269"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2009" name="Genetics" volume="183" first="1357" last="1372">
            <title>Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.</title>
            <authorList>
                <person name="Locke C.J."/>
                <person name="Kautu B.B."/>
                <person name="Berry K.P."/>
                <person name="Lee S.K."/>
                <person name="Caldwell K.A."/>
                <person name="Caldwell G.A."/>
            </authorList>
            <dbReference type="PubMed" id="19797046"/>
            <dbReference type="DOI" id="10.1534/genetics.109.106880"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLN-61</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2010" name="PLoS Biol." volume="8" first="E1000297" last="E1000297">
            <title>The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.</title>
            <authorList>
                <person name="Cabello J."/>
                <person name="Neukomm L.J."/>
                <person name="Guenesdogan U."/>
                <person name="Burkart K."/>
                <person name="Charette S.J."/>
                <person name="Lochnit G."/>
                <person name="Hengartner M.O."/>
                <person name="Schnabel R."/>
            </authorList>
            <dbReference type="PubMed" id="20126385"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.1000297"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2013" name="Development" volume="140" first="4020" last="4030">
            <title>C. elegans PVF-1 inhibits permissive UNC-40 signalling through CED-10 GTPase to position the male ray 1 sensillum.</title>
            <authorList>
                <person name="Dalpe G."/>
                <person name="Tarsitano M."/>
                <person name="Persico M.G."/>
                <person name="Zheng H."/>
                <person name="Culotti J."/>
            </authorList>
            <dbReference type="PubMed" id="24004945"/>
            <dbReference type="DOI" id="10.1242/dev.095190"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2014" name="Development" volume="141" first="4395" last="4405">
            <title>The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP.</title>
            <authorList>
                <person name="Norris A.D."/>
                <person name="Sundararajan L."/>
                <person name="Morgan D.E."/>
                <person name="Roberts Z.J."/>
                <person name="Lundquist E.A."/>
            </authorList>
            <dbReference type="PubMed" id="25371370"/>
            <dbReference type="DOI" id="10.1242/dev.110437"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF VAL-190</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005446" last="E1005446">
            <title>The Wnt frizzled receptor MOM-5 regulates the UNC-5 Netrin receptor through small GTPase-dependent signaling to determine the polarity of migrating cells.</title>
            <authorList>
                <person name="Levy-Strumpf N."/>
                <person name="Krizus M."/>
                <person name="Zheng H."/>
                <person name="Brown L."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="26292279"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005446"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="e1006163" last="e1006163">
            <title>The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions.</title>
            <authorList>
                <person name="Guan L."/>
                <person name="Ma X."/>
                <person name="Zhang J."/>
                <person name="Liu J.J."/>
                <person name="Wang Y."/>
                <person name="Ding M."/>
            </authorList>
            <dbReference type="PubMed" id="27415421"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006163"/>
        </citation>
        <scope>INTERACTION WITH CHDP-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF GLY-12; THR-17; SER-22; GLY-60 AND VAL-190</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2018" name="Genetics" volume="210" first="235" last="255">
            <title>Control of Growth Cone Polarity, Microtubule Accumulation, and Protrusion by UNC-6/Netrin and Its Receptors in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gujar M.R."/>
                <person name="Sundararajan L."/>
                <person name="Stricker A."/>
                <person name="Lundquist E.A."/>
            </authorList>
            <dbReference type="PubMed" id="30045855"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301234"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF VAL-190</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2018" name="PLoS Genet." volume="14" first="E1007125" last="E1007125">
            <title>6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33.</title>
            <authorList>
                <person name="Offenburger S.L."/>
                <person name="Ho X.Y."/>
                <person name="Tachie-Menson T."/>
                <person name="Coakley S."/>
                <person name="Hilliard M.A."/>
                <person name="Gartner A."/>
            </authorList>
            <dbReference type="PubMed" id="29346382"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1007125"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-60</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q03206-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q03206-2</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_005711"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_500362.3">
        <property type="nucleotide sequence ID" value="NM_067961.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C09G12.8a">
        <property type="protein sequence ID" value="CE16832"/>
        <property type="gene ID" value="WBGene00000424"/>
        <property type="gene designation" value="ced-10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="C09G12.8a"/>
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    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C09G12.8b"/>
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    </evidence>
    <sequence length="129" mass="14332" checksum="06BE559FFEFDE383" modified="2002-06-06" version="2" precursor="true">MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGRPINLGLWDTAGQEDYDRLRERRLQPVSQTQGYVMAKEIKAVKYLECSALTQRGLKQVFDEAIRAVLTPPQRAKKSKCTVL</sequence>
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<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="166" xmlns="https://uniprot.org/uniprot">
    <accession>Q09476-2</accession>
    <name>PXL1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Paxillin homolog 1</fullName>
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    </protein>
    <gene>
        <name type="primary">pxl-1</name>
        <name type="synonym">tag-327</name>
        <name type="ORF">C28H8.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2011" name="Mol. Biol. Cell" volume="22" first="2551" last="2563">
            <title>The Caenorhabditis elegans paxillin orthologue, PXL-1, is required for pharyngeal muscle contraction and for viability.</title>
            <authorList>
                <person name="Warner A."/>
                <person name="Qadota H."/>
                <person name="Benian G.M."/>
                <person name="Vogl A.W."/>
                <person name="Moerman D.G."/>
            </authorList>
            <dbReference type="PubMed" id="21633109"/>
            <dbReference type="DOI" id="10.1091/mbc.E10-12-0941"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09476-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09476-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_035943 VSP_020535 VSP_020534 VSP_020533"/>
        </isoform>
        <isoform>
            <id>Q09476-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_035944"/>
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    </comment>
    <dbReference type="RefSeq" id="NP_001021186.1">
        <property type="nucleotide sequence ID" value="NM_001026015.3"/>
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    <dbReference type="WormBase" id="C28H8.6b">
        <property type="protein sequence ID" value="CE37096"/>
        <property type="gene ID" value="WBGene00016197"/>
        <property type="gene designation" value="pxl-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
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    <proteinExistence type="evidence at transcript level"/>
    <sequence length="256" mass="28957" checksum="E18C317C558FB020" modified="2008-12-16" version="2">MMRELQQRLDHFNGPNYAQNSHSNHQQHHSVYSSRKSLGPPSQAQSYSDVRSNGRSPSRDPLHSDSMIGTMNGELSSKHGVNTIPKGDCAACGKPIIGQVVIALGKMWHPEHYTCCECGAELGQRPFFERNGRAFCEEDYHNQFSPKCQGCHRAITDRCVSVMNKNFHIECFTCAECNQPFGEDGFHEKNGQTYCKRDFFRLFAPKCNGCSQPITSNFITALGTHWHPDCFVCQGNTHFAQQCPMDVTYFEEENAY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="166" xmlns="https://uniprot.org/uniprot">
    <accession>Q09476-3</accession>
    <name>PXL1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Paxillin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">pxl-1</name>
        <name type="synonym">tag-327</name>
        <name type="ORF">C28H8.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2011" name="Mol. Biol. Cell" volume="22" first="2551" last="2563">
            <title>The Caenorhabditis elegans paxillin orthologue, PXL-1, is required for pharyngeal muscle contraction and for viability.</title>
            <authorList>
                <person name="Warner A."/>
                <person name="Qadota H."/>
                <person name="Benian G.M."/>
                <person name="Vogl A.W."/>
                <person name="Moerman D.G."/>
            </authorList>
            <dbReference type="PubMed" id="21633109"/>
            <dbReference type="DOI" id="10.1091/mbc.E10-12-0941"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Podosome</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09476-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09476-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020534 VSP_035943 VSP_020535 VSP_020533"/>
        </isoform>
        <isoform>
            <id>Q09476-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_035944"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001122677.1">
        <property type="nucleotide sequence ID" value="NM_001129205.4"/>
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    <dbReference type="WormBase" id="C28H8.6c">
        <property type="protein sequence ID" value="CE41531"/>
        <property type="gene ID" value="WBGene00016197"/>
        <property type="gene designation" value="pxl-1"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
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    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="21633109"/>
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    <sequence length="352" mass="39570" checksum="F204DC596B776EFE" modified="2008-12-16" version="2">MPSDDRFADAVKPALEALLSDLQHTTEVLRRAHISDRRSQSRDDFEQSYDLQGNLNTQSSRKSLGPPSQAQSYSDVRSNGRSPSRDPLHSDSMIGTMNGELSSKHGVNTIPKGDCAACGKPIIGQVVIALGKMWHPEHYTCCECGAELGQRPFFERNGRAFCEEDYHNQFSPKCQGCHRAITDRCVSVMNKNFHIECFTCAECNQPFGEDGFHEKNGQTYCKRDFFRLFAPKCNGCSQPITSNFITALGTHWHPDCFVCQHCGVSFNGASFFEHNGAPLCERHYHESRGSICSQCRGAINGRCVAAMGRKFHPEHFRCSYCNHQLTKGTFKEVDRRPFCHKCYNNTYALTPA</sequence>
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<entry dataset="Swiss-Prot" created="1996-02-01" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q10121-2</accession>
    <name>YSD2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of RutC family protein C23G10.2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">C23G10.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q10121-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q10121-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_013905"/>
        </isoform>
        <isoform>
            <id>Q10121-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_013906"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741178.1">
        <property type="nucleotide sequence ID" value="NM_171873.6"/>
    </dbReference>
    <dbReference type="WormBase" id="C23G10.2b">
        <property type="protein sequence ID" value="CE30613"/>
        <property type="gene ID" value="WBGene00016011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="144" mass="15192" checksum="F0464BDB5835BDCA" modified="2005-06-07" version="3">MRTKVLDMAQKVTRQIISSANAPGAIGPYSQAVRAGNTIYLSGSLGLDPKTGDLKEGVVEQTHQSLKNLGEVLKAAGADYGNVVKTTVLLQNIADFAAVNEVYGQYFKSPYPARAAYQVAALPKGGLVEIEAVAIAGEIEEVKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q10121-3</accession>
    <name>YSD2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of RutC family protein C23G10.2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">C23G10.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q10121-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_013905"/>
        </isoform>
        <isoform>
            <id>Q10121-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q10121-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_013906"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021179.1">
        <property type="nucleotide sequence ID" value="NM_001026008.6"/>
    </dbReference>
    <dbReference type="WormBase" id="C23G10.2c">
        <property type="protein sequence ID" value="CE37748"/>
        <property type="gene ID" value="WBGene00016011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="137" mass="14348" checksum="C768546270A907EF" modified="2005-06-07" version="3">MAQKVTRQIISSANAPGAIGPYSQAVRAGNTIYLSGSLGLDPKTGDLKEGVVEQTHQSLKNLGEVLKAAGADYGNVVKTTVLLQNIADFAAVNEVYGQYFKSPYPARAAYQVAALPKGGLVEIEAVAIAGEIEEVKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q11178-2</accession>
    <name>ATTF4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of AT hook-containing protein attf-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">attf-4</name>
        <name evidence="2" type="ORF">C05D10.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q11178-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_057814"/>
        </isoform>
        <isoform>
            <id>Q11178-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q11178-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_057815 VSP_057816"/>
        </isoform>
    </comment>
    <dbReference type="WormBase" id="C05D10.1b">
        <property type="protein sequence ID" value="CE30420"/>
        <property type="gene ID" value="WBGene00015477"/>
        <property type="gene designation" value="attf-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C05D10.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C05D10.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C05D10.1c"/>
        </source>
    </evidence>
    <sequence length="425" mass="45807" checksum="278A8FFA525818C1" modified="2002-06-06" version="2">MEDDVNQKDEDEDLNLVDRVSKLETNFVFIQHQLSSIMNHLHAPQCKCTTCSKVNQPGAEEQKNDTSVLSQLFPNASDQQLKTLLDLSKMNKLPPPVASYYQRKESSNPLVPPTPLSSIPNLITNSNAVSANTSTASPGPSSEGSGDDHLEAPNEVAHMHSSTVPATPTTPGANLFTQSMVDMLKLNAQNAAHSTGSPGFLRGRGRGRPKLIGDELDADLVDYMVSLKNSDPHGGHFTASQALHMARQYILERAPGLLEEHGGHVKLKLTWAMKLVSRIGERQREIELGLPAGTLSNMGRNLTNIPAGGNFMADMMAQNIFSQHMMMVNQQLEGGSPPASSSSTATTSTATKTVKQESKNGHQNEENLNVKQEASTMPEIINIKELNLPFLNNFLAELNDNNSGLIDGEIGAAGPSMAALFAPNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q11178-3</accession>
    <name>ATTF4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of AT hook-containing protein attf-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">attf-4</name>
        <name evidence="2" type="ORF">C05D10.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q11178-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_057815 VSP_057816"/>
        </isoform>
        <isoform>
            <id>Q11178-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q11178-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_057814"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367435.1">
        <property type="nucleotide sequence ID" value="NM_001379742.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C05D10.1c">
        <property type="protein sequence ID" value="CE37698"/>
        <property type="gene ID" value="WBGene00015477"/>
        <property type="gene designation" value="attf-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C05D10.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C05D10.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C05D10.1c"/>
        </source>
    </evidence>
    <sequence length="457" mass="48885" checksum="CC834D3ED3C8C953" modified="2002-06-06" version="2">MNHLHAPQCKCTTCSKVNQPGAEEQKNDTSVLSQLFPNASDQQLKTLLDLSKMNKLPSQVVHKDQQNGSSFLPSANKTSENPKPIELKPLKLGQGYQMANGGGGGKIHTERLSEPARKQSRKVGFPPPVASYYQRKESSNPLVPPTPLSSIPNLITNSNAVSANTSTASPGPSSEGSGDDHLEAPNEVAHMHSSTVPATPTTPGANLFTQSMVDMLKLNAQNAAHSTGSPGFLRGRGRGRPKLIGDELDADLVDYMVSLKNSDPHGGHFTASQALHMARQYILERAPGLLEEHGGHVKLKLTWAMKLVSRIGERQREIELGLPAGTLSNMGRNLTNIPAGGNFMADMMAQNIFSQHMMMVNQQLEGGSPPASSSSTATTSTATKTVKQESKNGHQNEENLNVKQEASTMPEIINIKELNLPFLNNFLAELNDNNSGLIDGEIGAAGPSMAALFAPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="190" xmlns="https://uniprot.org/uniprot">
    <accession>Q18291</accession>
    <accession>Q18294</accession>
    <name>Q18291_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neurexin-3-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nrx-1</name>
        <name evidence="15" type="ORF">C29A12.4</name>
        <name evidence="13" type="ORF">CELE_C29A12.4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA98243.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256262.1">
        <property type="nucleotide sequence ID" value="NM_001269333.4"/>
    </dbReference>
    <dbReference type="SMR" id="Q18291"/>
    <dbReference type="GeneID" id="179503"/>
    <dbReference type="UCSC" id="C29A12.4">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007799"/>
    <dbReference type="CTD" id="42646"/>
    <dbReference type="WormBase" id="C29A12.4a">
        <property type="protein sequence ID" value="CE46835"/>
        <property type="gene ID" value="WBGene00007799"/>
        <property type="gene designation" value="nrx-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275838at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007799">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18291">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000015">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF89">
        <property type="entry name" value="NEUREXIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1424"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="28"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="219"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="269"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="467"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="652"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="693"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="875"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1056"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="1097"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1381"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="1026"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAA98243.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="C29A12.4a"/>
        </source>
    </evidence>
    <sequence length="1540" mass="172903" checksum="7A7484A565ED155B" modified="2012-03-21" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q18879-2</accession>
    <name>CAV2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Caveolin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cav-2</name>
        <name type="ORF">C56A3.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Biol. Chem." volume="272" first="2437" last="2445">
            <title>Identification, sequence, and expression of an invertebrate caveolin gene family from the nematode Caenorhabditis elegans. Implications for the molecular evolution of mammalian caveolin genes.</title>
            <authorList>
                <person name="Tang Z."/>
                <person name="Okamoto T."/>
                <person name="Boontrakulpoontawee P."/>
                <person name="Katada T."/>
                <person name="Otsuka A.J."/>
                <person name="Lisanti M.P."/>
            </authorList>
            <dbReference type="PubMed" id="8999956"/>
            <dbReference type="DOI" id="10.1074/jbc.272.45.28704"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Commun. Integr. Biol." volume="2" first="382" last="384">
            <title>Overexpression of caveolins in Caenorhabditis elegans induces changes in egg-laying and fecundity.</title>
            <authorList>
                <person name="Parker S."/>
                <person name="Baylis H.A."/>
            </authorList>
            <dbReference type="PubMed" id="19907693"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="1763" last="1771">
            <title>Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Parker S."/>
                <person name="Walker D.S."/>
                <person name="Ly S."/>
                <person name="Baylis H.A."/>
            </authorList>
            <dbReference type="PubMed" id="19158391"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-08-0837"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q18879-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_043964"/>
        </isoform>
        <isoform>
            <id>Q18879-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q18879-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_043962"/>
        </isoform>
        <isoform>
            <id>Q18879-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_043963"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001256525.1">
        <property type="nucleotide sequence ID" value="NM_001269596.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C56A3.7b">
        <property type="protein sequence ID" value="CE45292"/>
        <property type="gene ID" value="WBGene00000302"/>
        <property type="gene designation" value="cav-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="319" mass="37122" checksum="CE453BC708A54FDC" modified="2012-06-13" version="3">MDKEDHHHHHHHHEHHHQHQGIAQYDTVEEVETLETVHHRTSLNQEVPTPQRRSHPQYDNLDDIDDQEYITEVEVKSNRGSTLTTRPHVTIKQDEIEDIGERQVTVIEIASQKGSTKRVAPRKDYAPSIPLPEHPAQQSAPPTQQSRPQTTSHKPPNPEMEFDIGVKNIAPVLIHKMNMDDRDPKDSAQYLNTSFFEVFNEPSEQYHSIACVWTLSFKIFEIVRIYSYKILTLIFGLIIAFLGGILFALFAFLNIWIFRPILILTRMAFAQIVLIWPMFLIYIVRPFFYSVGAIFSTARLHTSRGEQVVEVWEKHIHHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q18879-3</accession>
    <name>CAV2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Caveolin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cav-2</name>
        <name type="ORF">C56A3.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Biol. Chem." volume="272" first="2437" last="2445">
            <title>Identification, sequence, and expression of an invertebrate caveolin gene family from the nematode Caenorhabditis elegans. Implications for the molecular evolution of mammalian caveolin genes.</title>
            <authorList>
                <person name="Tang Z."/>
                <person name="Okamoto T."/>
                <person name="Boontrakulpoontawee P."/>
                <person name="Katada T."/>
                <person name="Otsuka A.J."/>
                <person name="Lisanti M.P."/>
            </authorList>
            <dbReference type="PubMed" id="8999956"/>
            <dbReference type="DOI" id="10.1074/jbc.272.45.28704"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Commun. Integr. Biol." volume="2" first="382" last="384">
            <title>Overexpression of caveolins in Caenorhabditis elegans induces changes in egg-laying and fecundity.</title>
            <authorList>
                <person name="Parker S."/>
                <person name="Baylis H.A."/>
            </authorList>
            <dbReference type="PubMed" id="19907693"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="1763" last="1771">
            <title>Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Parker S."/>
                <person name="Walker D.S."/>
                <person name="Ly S."/>
                <person name="Baylis H.A."/>
            </authorList>
            <dbReference type="PubMed" id="19158391"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-08-0837"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q18879-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_043964"/>
        </isoform>
        <isoform>
            <id>Q18879-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q18879-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_043963"/>
        </isoform>
        <isoform>
            <id>Q18879-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_043962"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001256526.1">
        <property type="nucleotide sequence ID" value="NM_001269597.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C56A3.7c">
        <property type="protein sequence ID" value="CE45320"/>
        <property type="gene ID" value="WBGene00000302"/>
        <property type="gene designation" value="cav-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="160" mass="18782" checksum="5B4E592CCF48FDFE" modified="2012-06-13" version="3">MEFDIGVKNIAPVLIHKMNMDDRDPKDSAQYLNTSFFEVFNEPSEQYHSIACVWTLSFKIFEIVRIYSYKILTLIFGLIIAFLGGILFALFAFLNIWIFRPILILTRMAFAQIVLIWPMFLIYIVRPFFYSVGAIFSTARLHTSRGEQVVEVWEKHIHHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q18879-4</accession>
    <name>CAV2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform d of Caveolin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cav-2</name>
        <name type="ORF">C56A3.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Biol. Chem." volume="272" first="2437" last="2445">
            <title>Identification, sequence, and expression of an invertebrate caveolin gene family from the nematode Caenorhabditis elegans. Implications for the molecular evolution of mammalian caveolin genes.</title>
            <authorList>
                <person name="Tang Z."/>
                <person name="Okamoto T."/>
                <person name="Boontrakulpoontawee P."/>
                <person name="Katada T."/>
                <person name="Otsuka A.J."/>
                <person name="Lisanti M.P."/>
            </authorList>
            <dbReference type="PubMed" id="8999956"/>
            <dbReference type="DOI" id="10.1074/jbc.272.45.28704"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Commun. Integr. Biol." volume="2" first="382" last="384">
            <title>Overexpression of caveolins in Caenorhabditis elegans induces changes in egg-laying and fecundity.</title>
            <authorList>
                <person name="Parker S."/>
                <person name="Baylis H.A."/>
            </authorList>
            <dbReference type="PubMed" id="19907693"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="1763" last="1771">
            <title>Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Parker S."/>
                <person name="Walker D.S."/>
                <person name="Ly S."/>
                <person name="Baylis H.A."/>
            </authorList>
            <dbReference type="PubMed" id="19158391"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-08-0837"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q18879-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_043962"/>
        </isoform>
        <isoform>
            <id>Q18879-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_043964"/>
        </isoform>
        <isoform>
            <id>Q18879-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q18879-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_043963"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001256524.1">
        <property type="nucleotide sequence ID" value="NM_001269595.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C56A3.7d">
        <property type="protein sequence ID" value="CE46485"/>
        <property type="gene ID" value="WBGene00000302"/>
        <property type="gene designation" value="cav-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="281" mass="32362" checksum="785D27F2A9A27454" modified="2012-06-13" version="3">MTRQNTSESDNTQRPPIPQYDTVDDIDDQEYITEVEVKSNRGSTLTTRPHVTIKQDEIEDIGERQVTVIEIASQKGSTKRVAPRKDYAPSIPLPEHPAQQSAPPTQQSRPQTTSHKPPNPEMEFDIGVKNIAPVLIHKMNMDDRDPKDSAQYLNTSFFEVFNEPSEQYHSIACVWTLSFKIFEIVRIYSYKILTLIFGLIIAFLGGILFALFAFLNIWIFRPILILTRMAFAQIVLIWPMFLIYIVRPFFYSVGAIFSTARLHTSRGEQVVEVWEKHIHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="168" xmlns="https://uniprot.org/uniprot">
    <accession>Q19581</accession>
    <name>Q19581_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyadenylate-binding protein</fullName>
            <shortName evidence="5">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">pab-2</name>
        <name evidence="9" type="ORF">CELE_F18H3.3</name>
        <name evidence="11" type="ORF">F18H3.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAA90446.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379082.1">
        <property type="nucleotide sequence ID" value="NM_001392874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19581"/>
    <dbReference type="SMR" id="Q19581"/>
    <dbReference type="PeptideAtlas" id="Q19581"/>
    <dbReference type="GeneID" id="181473"/>
    <dbReference type="UCSC" id="F18H3.3a.3">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003903"/>
    <dbReference type="CTD" id="181473"/>
    <dbReference type="WormBase" id="F18H3.3b">
        <property type="protein sequence ID" value="CE46847"/>
        <property type="gene ID" value="WBGene00003903"/>
        <property type="gene designation" value="pab-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_22_4_1"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003903">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q19581">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000009">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polyadenylate-binding protein"/>
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        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
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        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="121"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="226"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="8">
        <location>
            <begin position="484"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAA90446.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F18H3.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="Q19581"/>
        </source>
    </evidence>
    <sequence length="575" mass="63726" checksum="5457F5D7F0E26CE1" modified="2012-03-21" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="175" xmlns="https://uniprot.org/uniprot">
    <accession>Q19583</accession>
    <name>Q19583_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uridine kinase</fullName>
            <ecNumber evidence="10">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CELE_F19B6.1</name>
        <name evidence="14 16" type="ORF">F19B6.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="10"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA93459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21107">
        <property type="entry name" value="T21107"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19583"/>
    <dbReference type="SMR" id="Q19583"/>
    <dbReference type="PeptideAtlas" id="Q19583"/>
    <dbReference type="UCSC" id="F19B6.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008948"/>
    <dbReference type="WormBase" id="F19B6.1a">
        <property type="protein sequence ID" value="CE05666"/>
        <property type="gene ID" value="WBGene00008948"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_0_1_1"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008948">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q19583">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="12">
        <location>
            <begin position="66"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="301"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAA93459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="F19B6.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="Q19583"/>
        </source>
    </evidence>
    <sequence length="515" mass="58452" checksum="9584D947A2D3B5C5" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-12" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q20010-2</accession>
    <name>SAS5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Spindle assembly abnormal protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sas-5</name>
        <name type="ORF">F35B12.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Dev. Cell" volume="7" first="815" last="829">
            <title>Centriole assembly requires both centriolar and pericentriolar material proteins.</title>
            <authorList>
                <person name="Dammermann A."/>
                <person name="Mueller-Reichert T."/>
                <person name="Pelletier L."/>
                <person name="Habermann B."/>
                <person name="Desai A."/>
                <person name="Oegema K."/>
            </authorList>
            <dbReference type="PubMed" id="15572125"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2004.10.015"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Nat. Cell Biol." volume="6" first="656" last="664">
            <title>Centriolar SAS-5 is required for centrosome duplication in C. elegans.</title>
            <authorList>
                <person name="Delattre M."/>
                <person name="Leidel S."/>
                <person name="Wani K."/>
                <person name="Baumer K."/>
                <person name="Bamat J."/>
                <person name="Schnabel H."/>
                <person name="Feichtinger R."/>
                <person name="Schnabel R."/>
                <person name="Goenczy P."/>
            </authorList>
            <dbReference type="PubMed" id="15232593"/>
            <dbReference type="DOI" id="10.1038/ncb1146"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ARG-397</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Nat. Cell Biol." volume="7" first="115" last="125">
            <title>SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells.</title>
            <authorList>
                <person name="Leidel S."/>
                <person name="Delattre M."/>
                <person name="Cerutti L."/>
                <person name="Baumer K."/>
                <person name="Goenczy P."/>
            </authorList>
            <dbReference type="PubMed" id="15665853"/>
            <dbReference type="DOI" id="10.1038/ncb1220"/>
        </citation>
        <scope>INTERACTION WITH SAS-6</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Dev. Cell" volume="20" first="550" last="562">
            <title>PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos.</title>
            <authorList>
                <person name="Kitagawa D."/>
                <person name="Fluckiger I."/>
                <person name="Polanowska J."/>
                <person name="Keller D."/>
                <person name="Reboul J."/>
                <person name="Gonczy P."/>
            </authorList>
            <dbReference type="PubMed" id="21497765"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2011.02.005"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH LET-92</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q20010-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q20010-2</id>
            <name>c</name>
            <sequence type="described" ref="VSP_044039"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001256339.1">
        <property type="nucleotide sequence ID" value="NM_001269410.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F35B12.5c">
        <property type="protein sequence ID" value="CE05804"/>
        <property type="gene ID" value="WBGene00009385"/>
        <property type="gene designation" value="sas-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="288" mass="33367" checksum="DBAA820190361E7A" modified="2001-10-01" version="2">MSAQNTTTTEEQAAENWRDAMKTELQTIRTEIQEETARRQEELNAQNLVKMQELMSNFFQKITIPKQQAIEPVEKDKENFHESPRQSRQQKPASKIASAREVIKRDGVIPPEALTIIEQRLRSDPMFRQQIDNVLADAECDANRAAYSPPPPMSEVRYGSGVNPALMRETLTVERSIRYDNGLASIDSRQWTNERRDNRAPDSYRTYEPDQPCHSLYQKGQSISYYPSEAAGKTTARNNRTGYYVEDSSDHEEDVVVNKRGQNYHEQAVPETPAERERRIREKYARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q20584</accession>
    <name>Q20584_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHK kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F49C12.7</name>
        <name evidence="3 5" type="ORF">F49C12.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA92511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T22412">
        <property type="entry name" value="T22412"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040947.1">
        <property type="nucleotide sequence ID" value="NM_001047482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q20584"/>
    <dbReference type="PeptideAtlas" id="Q20584"/>
    <dbReference type="GeneID" id="177751"/>
    <dbReference type="KEGG" id="cel:CELE_F49C12.7"/>
    <dbReference type="UCSC" id="F49C12.7c.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009877"/>
    <dbReference type="CTD" id="177751"/>
    <dbReference type="WormBase" id="F49C12.7a">
        <property type="protein sequence ID" value="CE03367"/>
        <property type="gene ID" value="WBGene00009877"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_765551_0_0_1"/>
    <dbReference type="OrthoDB" id="5777157at2759"/>
    <dbReference type="PhylomeDB" id="Q20584"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009877">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q20584">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF15">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="2">
        <location>
            <begin position="186"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA92511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F49C12.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q20584"/>
        </source>
    </evidence>
    <sequence length="444" mass="49698" checksum="23136B13D2DAF954" modified="1996-11-01" version="1">MGLCQSTVDVSPAKSNSEENVEKERKAISEMLKTAELADGLLGTTLQWEDVQKIAEESAGHNLKIGEKKTIKPLAEGVGLQSLLGIAEIDWEVEGDDKAPYPNKFALKIGSPVALLQALEAQAAKLPPDVAANISDEFISFLPPCHNSENYFYKYIQSLPKLDILPDFYFGNQIELEKDGNYSKGCIAIELVEDIKTLSPLENFSDDQMLQVLDALAKLQVQFINLSEDKRREAPHQGLSGLYSPFKDWFLQLNNGLMALFPDPEMQKLTETFATTLPEIITADELDLVPCKLGMKKVFVHGDLWSANIMWNQEGHLKKLIDFQMIHFGLAATDLARVMNTCLSPEERHANKEKYLKHYFDCLTKHCKEDDHPVPFDLEQLTTTYNLAYPRVSAYLLPALTAVLEKVVSMPNIPAKPMVIGSFISKVKGIYSDIIATHESRPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q20599</accession>
    <name>Q20599_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carotenoid oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_F49E10.2</name>
        <name evidence="7 9" type="ORF">F49E10.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD71564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34293">
        <property type="entry name" value="T34293"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508987.1">
        <property type="nucleotide sequence ID" value="NM_076586.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q20599"/>
    <dbReference type="SMR" id="Q20599"/>
    <dbReference type="PeptideAtlas" id="Q20599"/>
    <dbReference type="GeneID" id="180855"/>
    <dbReference type="UCSC" id="F49E10.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018640"/>
    <dbReference type="CTD" id="180855"/>
    <dbReference type="WormBase" id="F49E10.2a">
        <property type="protein sequence ID" value="CE07263"/>
        <property type="gene ID" value="WBGene00018640"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017102_0_0_1"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018640">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q20599">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF129">
        <property type="entry name" value="CAROTENOID OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004199023" evidence="6">
        <location>
            <begin position="18"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="575"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="581"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD71564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F49E10.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q20599"/>
        </source>
    </evidence>
    <sequence length="790" mass="88923" checksum="B1AE384B8FECB846" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q564P9</accession>
    <name>Q564P9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">suox-1</name>
        <name evidence="7" type="ORF">CELE_H13N06.4</name>
        <name evidence="9" type="ORF">H13N06.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAI79198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379444.1">
        <property type="nucleotide sequence ID" value="NM_001392901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q564P9"/>
    <dbReference type="SMR" id="Q564P9"/>
    <dbReference type="PeptideAtlas" id="Q564P9"/>
    <dbReference type="GeneID" id="181638"/>
    <dbReference type="UCSC" id="H13N06.4b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010397"/>
    <dbReference type="CTD" id="181638"/>
    <dbReference type="WormBase" id="H13N06.4b">
        <property type="protein sequence ID" value="CE38383"/>
        <property type="gene ID" value="WBGene00010397"/>
        <property type="gene designation" value="suox-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1511965_0_0_1"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010397">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q564P9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF95">
        <property type="entry name" value="CYTOCHROME B5 TYPE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAI79198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="H13N06.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q564P9"/>
        </source>
    </evidence>
    <sequence length="178" mass="20348" checksum="15DA5FA0E2F38CD1" modified="2005-05-10" version="1">MLGRGTSFNRFFRHRRQFNKLSGATSEHQRTNENHSYYKYAYIGGAATAGVLGFKHFVKTAKLDHAKDETMSEKKLENLQIYKQEEVKKHGKDADRIWVTYKDGVYDVTDFIAMHPGGDKILLAAGAAVDPFWALYSQHKTKEVLEILEGYRIGKLDVKDVPKIDFEDLSNVSLVDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q564S2</accession>
    <name>Q564S2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_K10C3.5</name>
        <name evidence="4 6" type="ORF">K10C3.5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAI79209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021565.1">
        <property type="nucleotide sequence ID" value="NM_001026394.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q564S2"/>
    <dbReference type="SMR" id="Q564S2"/>
    <dbReference type="PeptideAtlas" id="Q564S2"/>
    <dbReference type="GeneID" id="172838"/>
    <dbReference type="UCSC" id="K10C3.5b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010732"/>
    <dbReference type="CTD" id="172838"/>
    <dbReference type="WormBase" id="K10C3.5b">
        <property type="protein sequence ID" value="CE38396"/>
        <property type="gene ID" value="WBGene00010732"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_3_1_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010732">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q564S2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001718">
        <property type="entry name" value="Elongation factor Tu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAI79209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="K10C3.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q564S2"/>
        </source>
    </evidence>
    <sequence length="705" mass="78400" checksum="4A9B8728EE78FD4C" modified="2005-05-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q564T0</accession>
    <name>Q564T0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Golgi-associated PDZ and coiled-coil motif-containing protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CFTR-associated ligand</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">PDZ protein interacting specifically with TC10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">gopc-1</name>
        <name evidence="20" type="ORF">CELE_ZK849.2</name>
        <name evidence="22" type="ORF">ZK849.2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAI79281.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021878.2">
        <property type="nucleotide sequence ID" value="NM_001026707.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q564T0"/>
    <dbReference type="SMR" id="Q564T0"/>
    <dbReference type="IntAct" id="Q564T0">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="3565651"/>
    <dbReference type="UCSC" id="ZK849.2c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00014101"/>
    <dbReference type="CTD" id="3565651"/>
    <dbReference type="WormBase" id="ZK849.2b">
        <property type="protein sequence ID" value="CE40679"/>
        <property type="gene ID" value="WBGene00014101"/>
        <property type="gene designation" value="gopc-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10063653at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014101">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q564T0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06800">
        <property type="entry name" value="PDZ_GOPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000067">
        <property type="entry name" value="Golgi-associated PDZ and coiled-coil motif-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038879">
        <property type="entry name" value="GOPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16528">
        <property type="entry name" value="GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16528:SF2">
        <property type="entry name" value="GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="283"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAI79281.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="ZK849.2b"/>
        </source>
    </evidence>
    <sequence length="412" mass="46090" checksum="674A87006FA1BEB6" modified="2007-03-20" version="2">MSHCAACSGARLQAQTVLRVDPESEYFECEASAMEGGSGWTESLEKDFDKAFVSLDLLLGEVDSDQITYEGRQKMTSLSACFAQMMHKCQFMMHTISKQEKEMITMRAEVVEARAARQSMEKEVEQLMIQVHSLQCQLHSKTAPHESDMIKKKLETQLTQFRSELTQGLSTVCELEIARKECDRSKRTIQALETEVFGARLAAKYLDKELAGRIQQIQLLGRNMRGVEHDRLWNQLEAEIHLHRHKTVIRACRGRGNTKGLTAPLRHNFKSLRKRNGVGKSRKVVLSKHPHEGLGISITGGSEHALPIVISEIQPGQPADRCGQVFVGDAILSVNGYDLRTVKHQEAVDILSGQVQQGDLDLELVFVCPDEDSDDDGTVTIEHSDGSIYNLYSMEEPTSSRSSNNSDESRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q564U0</accession>
    <name>Q564U0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">clec-28</name>
        <name evidence="4" type="ORF">CELE_F49A5.5</name>
        <name evidence="6" type="ORF">F49A5.5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAI79191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023951.1">
        <property type="nucleotide sequence ID" value="NM_001028780.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q564U0"/>
    <dbReference type="SMR" id="Q564U0"/>
    <dbReference type="GeneID" id="186005"/>
    <dbReference type="UCSC" id="F49A5.5a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009857"/>
    <dbReference type="CTD" id="186005"/>
    <dbReference type="WormBase" id="F49A5.5b">
        <property type="protein sequence ID" value="CE38363"/>
        <property type="gene ID" value="WBGene00009857"/>
        <property type="gene designation" value="clec-28"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037161_1_0_1"/>
    <dbReference type="OrthoDB" id="5779307at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009857">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q564U0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050976">
        <property type="entry name" value="Snaclec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22991:SF43">
        <property type="entry name" value="C-TYPE LECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22991">
        <property type="entry name" value="PROTEIN CBG13490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="151"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="286"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAI79191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F49A5.5b"/>
        </source>
    </evidence>
    <sequence length="400" mass="43972" checksum="DCF7C01702A1A9AB" modified="2005-05-10" version="1">MSDIDEIQELQEPSQPKTQPYSEKFKLFMTNHWKNILIGGLAEIIIIVFAFMLTFILAKQPACETVTTSIFHTSTLPSTLTYASSSYSTKPDKSSIATSTTLKPKTLPVTTTSNSLSTHTKLDTTSISATFATMPTPVSGNLTCASGFTYVGNKCWKLVTVQKNRADADQACFSLGGSTLFSIRNDQDNQAVLEFLKDQHVENLWTGLNCVGINPFTCTWDVKSGTTSAYNNFADGYPNNMAGGCIYYKTTGTQAGQWSSGSCNEIMSFVCELPATIYDSTCKYNYNNYCYTPYDQLQISSDAQSICASSGSNLATIHSANENRFFMGIFPSFSMIALGGVALSGDKVIWYDGTPSTYTNIRTLTRGNCILLSNDVGRWDGYKCMIDRAKFICKRRIIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2025-10-08" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q564V0</accession>
    <name>Q564V0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_F02E9.10</name>
        <name evidence="5 7" type="ORF">F02E9.10</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAI79161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021084.1">
        <property type="nucleotide sequence ID" value="NM_001025913.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q564V0"/>
    <dbReference type="SMR" id="Q564V0"/>
    <dbReference type="PeptideAtlas" id="Q564V0"/>
    <dbReference type="GeneID" id="172630"/>
    <dbReference type="UCSC" id="F02E9.10c.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008533"/>
    <dbReference type="CTD" id="172630"/>
    <dbReference type="WormBase" id="F02E9.10b">
        <property type="protein sequence ID" value="CE38314"/>
        <property type="gene ID" value="WBGene00008533"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627368_0_0_1"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008533">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q564V0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAI79161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F02E9.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q564V0"/>
        </source>
    </evidence>
    <sequence length="387" mass="43662" checksum="AACA7864AEC53191" modified="2005-05-10" version="1">MDDMMNEEGIPQATIVAKYEKAHNRSVVGIWSFRFCGQIGMLSVSHDCSKLWILQEDSSNNISLDERMVLAKWRTAIQAADISVDGKYMVAVGMNSIVYEVELSRDAKYLAIGQLDGAIEMLYSENFKNYHKYEVHSMRIRKIEFLPNEERFLSACDDRLIKLHSLSEFTETDPSRSTKAIRVYSAHDAPVTGLTIDEKSGGTRFASSSASSQIFIWHIEMTTPIMSITNEHTSTISALSFSPTSRHLLSGGDDAMILIYRIPGVGENTPVHVAYYPPVEQPSDITEPESSSQLAEVPSASPYDEHDQQENEPPSDYTQEGGHEYYRSHEEYDAAQYQEYNPYAEPRTPPREDDEEIGNYVYNSTTEHQQNNESASPPAHEQYDPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q564V5</accession>
    <name>Q564V5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">exo-3</name>
        <name evidence="10" type="ORF">CELE_R09B3.1</name>
        <name evidence="12" type="ORF">R09B3.1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7 8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7 8">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAI79211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021585.1">
        <property type="nucleotide sequence ID" value="NM_001026414.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q564V5"/>
    <dbReference type="SMR" id="Q564V5"/>
    <dbReference type="PeptideAtlas" id="Q564V5"/>
    <dbReference type="GeneID" id="173069"/>
    <dbReference type="UCSC" id="R09B3.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001372"/>
    <dbReference type="CTD" id="173069"/>
    <dbReference type="WormBase" id="R09B3.1b">
        <property type="protein sequence ID" value="CE38407"/>
        <property type="gene ID" value="WBGene00001372"/>
        <property type="gene designation" value="exo-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1455670_0_0_1"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001372">
        <property type="expression patterns" value="Expressed in adult organism and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q564V5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAI79211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="R09B3.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="Q564V5"/>
        </source>
    </evidence>
    <sequence length="186" mass="21031" checksum="E14110040C8B5D7B" modified="2005-05-10" version="1">MSKRKAEEAPAPKLASIFTKKVKPAEEDNNQKSWKFVCWNVAGLRACVKKSDFKEVLAEEPDLVFLGETKCKEWPPEMEETFKNYTKTLVVSTEKNGGYAGVGLLSKCAPMKVHKGIGDPEFDTAGRLIIAEFSKFYFIGAYVPNSGAKLVNLEKRGRWEKLLTEKMKEMDEKKPVIYGESRIKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q564V6</accession>
    <name>Q564V6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">hbs-1</name>
        <name evidence="12" type="ORF">CELE_K07A12.4</name>
        <name evidence="14" type="ORF">K07A12.4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAI79193.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021556.2">
        <property type="nucleotide sequence ID" value="NM_001026385.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q564V6"/>
    <dbReference type="SMR" id="Q564V6"/>
    <dbReference type="PeptideAtlas" id="Q564V6"/>
    <dbReference type="GeneID" id="172672"/>
    <dbReference type="UCSC" id="K07A12.4b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010622"/>
    <dbReference type="CTD" id="172672"/>
    <dbReference type="WormBase" id="K07A12.4b">
        <property type="protein sequence ID" value="CE39389"/>
        <property type="gene ID" value="WBGene00010622"/>
        <property type="gene designation" value="hbs-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_6_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010622">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q564V6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000107">
        <property type="entry name" value="Related to translation elongation factor HBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="168"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAI79193.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="K07A12.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q564V6"/>
        </source>
    </evidence>
    <sequence length="592" mass="65240" checksum="CF94A9063343717D" modified="2005-12-20" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2025-10-08" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q564V7</accession>
    <name>Q564V7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">twk-29</name>
        <name evidence="12" type="ORF">CELE_F46A9.3</name>
        <name evidence="14" type="ORF">F46A9.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAI79227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021468.1">
        <property type="nucleotide sequence ID" value="NM_001026297.7"/>
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    <dbReference type="AlphaFoldDB" id="Q564V7"/>
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    <dbReference type="UCSC" id="F46A9.3b">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00006681"/>
    <dbReference type="CTD" id="185828"/>
    <dbReference type="WormBase" id="F46A9.3b">
        <property type="protein sequence ID" value="CE38354"/>
        <property type="gene ID" value="WBGene00006681"/>
        <property type="gene designation" value="twk-29"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
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    <dbReference type="Bgee" id="WBGene00006681">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q564V7">
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
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    <dbReference type="PANTHER" id="PTHR11003:SF69">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
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    <proteinExistence type="evidence at protein level"/>
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            <end position="44"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="156"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="180"/>
            <end position="200"/>
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        <location>
            <begin position="240"/>
            <end position="261"/>
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    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
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            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
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            <begin position="188"/>
            <end position="261"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="378"/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
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            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="396"/>
            <end position="405"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAI79227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F46A9.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q564V7"/>
        </source>
    </evidence>
    <sequence length="447" mass="50564" checksum="2EFF43D979774659" modified="2005-05-10" version="1">MSLLLFFGLGRCLQHNRRAIAVNGFIIVFLIIYTTIGGFIFLNFEFEYQQYMKQNATLEKRLCIESLLNRDNRLRLTRASDVAAAIAERCLTENVKDDRMQWSFKSAALYSLGILTTLGYGKIEPQTINGRISTVIYGFFGIPLTVILLTNFGRYLEAMATRFRRLISCRRRREDEDENVSGSTLFFIVLVYLILGATMIPLMSGQFDFFNGIYYAFICLTAIEYGDIIPQNNWFLPISVFYMCTGLAISTIALDIGSIYVRKLHFIGKKIKNIANIRIWFGARNLEVRELITAVGQNIGIDQNVIADIDIDTLVKTAIQVKLGRLSRVPQTHMIVEGIWPPELVPLFMKDGQFPLFVDSEDDLTDMRPKKFSVHFEDEPMMSEIEDTSDSETAADKSQTTSSRLSPIPRRRAMQAKLNGSTDSDQACHDGVMNVSTTITSDLSTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q564W2</accession>
    <name>Q564W2_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F28F8.9</name>
        <name evidence="1 3" type="ORF">F28F8.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAI79242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256676.1">
        <property type="nucleotide sequence ID" value="NM_001269747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q564W2"/>
    <dbReference type="SMR" id="Q564W2"/>
    <dbReference type="GeneID" id="3896822"/>
    <dbReference type="UCSC" id="F28F8.9">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00044188"/>
    <dbReference type="CTD" id="3896822"/>
    <dbReference type="WormBase" id="F28F8.9a">
        <property type="protein sequence ID" value="CE38333"/>
        <property type="gene ID" value="WBGene00044188"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1429215_0_0_1"/>
    <dbReference type="OrthoDB" id="5866729at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044188">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q564W2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAI79242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F28F8.9a"/>
        </source>
    </evidence>
    <sequence length="177" mass="21174" checksum="A31BF161352F4F6E" modified="2005-05-10" version="1">MARYLLGATMYVEDVLRRDDWSLEETENVKKYFKNVKSFKIPKIEKRKAEEFDEPCRKRCRVEKEKFENDLQAGIRLMTLFAGFEEIDEKALERLTDLAKLRIITSARQMAIAQRRRKDGFEIPFKSPVEWTLKLQGVQKVLDIKEWYDVTYWTRFRALKMQLIDENGDLKSPKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2025-10-08" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q56VY0</accession>
    <name>Q56VY0_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aat-9</name>
        <name evidence="7" type="ORF">CELE_Y53H1C.1</name>
        <name evidence="9" type="ORF">Y53H1C.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAI79268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="Q56VY0"/>
    <dbReference type="PeptideAtlas" id="Q56VY0"/>
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    <dbReference type="UCSC" id="Y53H1C.1a">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00000010"/>
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    <dbReference type="WormBase" id="Y53H1C.1b">
        <property type="protein sequence ID" value="CE38453"/>
        <property type="gene ID" value="WBGene00000010"/>
        <property type="gene designation" value="aat-9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_3_0_1"/>
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        <property type="component" value="Chromosome I"/>
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q56VY0">
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    </dbReference>
    <dbReference type="GO" id="GO:0009986">
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Amino Acid Transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF502">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAI79268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y53H1C.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q56VY0"/>
        </source>
    </evidence>
    <sequence length="527" mass="57885" checksum="19CA05058D8C77D6" modified="2005-05-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q56VZ4</accession>
    <name>Q56VZ4_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">DUF281 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y68A4A.10</name>
        <name evidence="3 5" type="ORF">Y68A4A.10</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAI79271.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q56VZ4"/>
    <dbReference type="UCSC" id="Y68A4A.10a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013469"/>
    <dbReference type="WormBase" id="Y68A4A.10b">
        <property type="protein sequence ID" value="CE53488"/>
        <property type="gene ID" value="WBGene00013469"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1005556_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005098">
        <property type="entry name" value="DUF281"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03436">
        <property type="entry name" value="DUF281"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020254963" evidence="1">
        <location>
            <begin position="16"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="DUF281" evidence="2">
        <location>
            <begin position="104"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DUF281" evidence="2">
        <location>
            <begin position="219"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAI79271.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y68A4A.10b"/>
        </source>
    </evidence>
    <sequence length="293" mass="30106" checksum="E3BA37C1D2A1507A" modified="2019-07-31" version="2">MIACLLFLLVQPTEPCMRMRPPEDVGVPGSLDPATTTIASGIQTTQCNTCTKTPQRVDPVKTTTKAPAATTKAVPLQCQKCTPFKDPMNAAAKCTATTGMNSPGCSTLSVKCTINAGFECDITKCMADPAYKCTDAALILDLTGGELTFTGTGPGKIAEASVTCGNDAVWVDSRGIRGNTLIASIAPQSCLPCQTCASFTDPMSEKATCTATPGMTPGDCATLAVKCMINAGFECNDVALILEITGGALETSGTGPGQIAETSVTCGNDKIWQDANGVRGNTLIASVAPQTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q69YZ0</accession>
    <name>Q69YZ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pqn-83</name>
        <name evidence="4" type="ORF">CELE_Y39E4B.3</name>
        <name evidence="6" type="ORF">Y39E4B.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAH10818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367104.1">
        <property type="nucleotide sequence ID" value="NM_001379973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q69YZ0"/>
    <dbReference type="PeptideAtlas" id="Q69YZ0"/>
    <dbReference type="GeneID" id="176729"/>
    <dbReference type="KEGG" id="cel:CELE_Y39E4B.3"/>
    <dbReference type="UCSC" id="Y39E4B.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004164"/>
    <dbReference type="CTD" id="176729"/>
    <dbReference type="WormBase" id="Y39E4B.3c">
        <property type="protein sequence ID" value="CE37169"/>
        <property type="gene ID" value="WBGene00004164"/>
        <property type="gene designation" value="pqn-83"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871812at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004164">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q69YZ0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002619">
        <property type="entry name" value="CX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520:SF8">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01705">
        <property type="entry name" value="CX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004270428" evidence="2">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="CX" evidence="3">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH10818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y39E4B.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q69YZ0"/>
        </source>
    </evidence>
    <sequence length="304" mass="30863" checksum="55035EAA218E494A" modified="2004-09-13" version="1">MFRHLYIGLISLLVLTAGPIEARRSSSGGGSLSGGGGGGGGFSSRGQSGSRTGVQQGTGGGGFNNNQGGFHPNQGSGGFNQPRPNNNFNNNPQGGFHPNPNQGGFHPNQGGFHPNNGGFRPGTGLGSQSSSGTFKKALIGGALGAAGGILAYEAGKAIIKSATEPFNYNGRNYNWDNHGQVRNGEFQCSIPLSQLTAQQSTTTTTPTTTSTTTASPDGSTTISPSSTTPTPEQVLQNIQYPDGSRPKNIVWACKAGREVCCGTDCCPAPVQNQNSAGGAGGSHGSGGSAGTIALMYLFALCFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q69YZ1</accession>
    <name>Q69YZ1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pqn-83</name>
        <name evidence="4" type="ORF">CELE_Y39E4B.3</name>
        <name evidence="6" type="ORF">Y39E4B.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAH10817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379425.1">
        <property type="nucleotide sequence ID" value="NM_001392224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q69YZ1"/>
    <dbReference type="GeneID" id="176729"/>
    <dbReference type="UCSC" id="Y39E4B.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004164"/>
    <dbReference type="CTD" id="176729"/>
    <dbReference type="WormBase" id="Y39E4B.3b">
        <property type="protein sequence ID" value="CE37168"/>
        <property type="gene ID" value="WBGene00004164"/>
        <property type="gene designation" value="pqn-83"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871812at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004164">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q69YZ1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002619">
        <property type="entry name" value="CX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520:SF8">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01705">
        <property type="entry name" value="CX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004270049" evidence="2">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="CX" evidence="3">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH10817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y39E4B.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q69YZ1"/>
        </source>
    </evidence>
    <sequence length="307" mass="31055" checksum="F69C458E2A5F1942" modified="2004-09-13" version="1">MFRHLYIGLISLLVLTAGPIEARRSSSGGGSLSGGGGGGGGFSSRGQSGSRTGVQQGTGGGGFNNNQGGFHPNQGSGGFNQPRPNNNFNNNPQGGFHPNPNQGGFHPNQGGFHPNNGGFRPGTGLGSQSSSGTFKKALIGGALGAAGGILAYEAGKAIIKSATEPFNYNGRNYNWDNHGQVRNGEFQCSIPLSQLTAQQSTTTTTPTTTSTTTASPDGSTTISPSSTTPTPEQVLQNIQYPDGSRPKNIVWACKAGREVCCGTDCCPAPVQNQNSAGGAGGSHGSGGSAGTIALMDNYGNAGLVQDY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JLI1-2</accession>
    <name>NAS31_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Zinc metalloproteinase nas-31</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Nematode astacin 31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nas-31</name>
        <name type="ORF">F58B4.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Eur. J. Biochem." volume="270" first="4909" last="4920">
            <title>The astacin protein family in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Moehrlen F."/>
                <person name="Hutter H."/>
                <person name="Zwilling R."/>
            </authorList>
            <dbReference type="PubMed" id="14653817"/>
            <dbReference type="DOI" id="10.1046/j.1432-1033.2003.03891.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 246-296 (ISOFORMS A AND B)</scope>
        <scope>NOMENCLATURE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="BMC Dev. Biol." volume="10" first="14" last="14">
            <title>Characterization of the astacin family of metalloproteases in C. elegans.</title>
            <authorList>
                <person name="Park J.O."/>
                <person name="Pan J."/>
                <person name="Moehrlen F."/>
                <person name="Schupp M.O."/>
                <person name="Johnsen R."/>
                <person name="Baillie D.L."/>
                <person name="Zapf R."/>
                <person name="Moerman D.G."/>
                <person name="Hutter H."/>
            </authorList>
            <dbReference type="PubMed" id="20109220"/>
            <dbReference type="DOI" id="10.1186/1471-213X-10-14"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q7JLI1-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q7JLI1-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_012357 VSP_012356"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001023993.1">
        <property type="nucleotide sequence ID" value="NM_001028822.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F58B4.1a">
        <property type="protein sequence ID" value="CE35881"/>
        <property type="gene ID" value="WBGene00003549"/>
        <property type="gene designation" value="nas-31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A8Q2D1"/>
        </source>
    </evidence>
    <sequence length="578" mass="64678" checksum="2975A841FE70E5E2" modified="2004-07-05" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z1J4</accession>
    <name>Q7Z1J4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leishmanolysin-like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y43F4A.1</name>
        <name evidence="3 5" type="ORF">Y43F4A.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAD92401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022871.1">
        <property type="nucleotide sequence ID" value="NM_001027700.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z1J4"/>
    <dbReference type="GeneID" id="176737"/>
    <dbReference type="UCSC" id="Y43F4A.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012796"/>
    <dbReference type="CTD" id="176737"/>
    <dbReference type="WormBase" id="Y43F4A.1b">
        <property type="protein sequence ID" value="CE34227"/>
        <property type="gene ID" value="WBGene00012796"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2814740_0_0_1"/>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012796">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z1J4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004295542" evidence="2">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD92401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y43F4A.1b"/>
        </source>
    </evidence>
    <sequence length="67" mass="7930" checksum="1CADFCF56EE984A8" modified="2003-10-01" version="1">MKPRLIFIFFACYFLNFLPFSNQLPCSYQNPRIEDILLEVPIEHEHPHRHRRGLPSSDPTSPPVEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z1J7</accession>
    <name>Q7Z1J7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome-b5 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_Y52B11A.3</name>
        <name evidence="8 10" type="ORF">Y52B11A.3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAD91715.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z1J7"/>
    <dbReference type="SMR" id="Q7Z1J7"/>
    <dbReference type="PeptideAtlas" id="Q7Z1J7"/>
    <dbReference type="UCSC" id="Y52B11A.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013123"/>
    <dbReference type="WormBase" id="Y52B11A.3b">
        <property type="protein sequence ID" value="CE41284"/>
        <property type="gene ID" value="WBGene00013123"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013123">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z1J7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000279">
        <property type="entry name" value="Protein CBG08008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000128">
        <property type="entry name" value="Protein CBG08008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="249"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD91715.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y52B11A.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q7Z1J7"/>
        </source>
    </evidence>
    <sequence length="516" mass="58661" checksum="150DE8A806DD86E9" modified="2007-07-10" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2025-10-08" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q86CZ7</accession>
    <name>Q86CZ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tag-273</name>
        <name evidence="7" type="ORF">CELE_Y57G11A.1</name>
        <name evidence="9" type="ORF">Y57G11A.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAD89758.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023517.2">
        <property type="nucleotide sequence ID" value="NM_001028346.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86CZ7"/>
    <dbReference type="SMR" id="Q86CZ7"/>
    <dbReference type="PeptideAtlas" id="Q86CZ7"/>
    <dbReference type="GeneID" id="178388"/>
    <dbReference type="UCSC" id="Y57G11A.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013289"/>
    <dbReference type="CTD" id="178388"/>
    <dbReference type="WormBase" id="Y57G11A.1b">
        <property type="protein sequence ID" value="CE42684"/>
        <property type="gene ID" value="WBGene00013289"/>
        <property type="gene designation" value="tag-273"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1679758at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013289">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86CZ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="190"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="589"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="713"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="739"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD89758.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y57G11A.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q86CZ7"/>
        </source>
    </evidence>
    <sequence length="785" mass="88040" checksum="41CBDE2665F9D942" modified="2008-07-22" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2025-10-08" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q86DA0</accession>
    <name>Q86DA0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PGM_PMM_I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">pgm-2</name>
        <name evidence="10" type="ORF">CELE_Y43F4B.5</name>
        <name evidence="12" type="ORF">Y43F4B.5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAD90182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022873.1">
        <property type="nucleotide sequence ID" value="NM_001027702.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86DA0"/>
    <dbReference type="SMR" id="Q86DA0"/>
    <dbReference type="PeptideAtlas" id="Q86DA0"/>
    <dbReference type="GeneID" id="176749"/>
    <dbReference type="UCSC" id="Y43F4B.5a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012803"/>
    <dbReference type="CTD" id="176749"/>
    <dbReference type="WormBase" id="Y43F4B.5b">
        <property type="protein sequence ID" value="CE34117"/>
        <property type="gene ID" value="WBGene00012803"/>
        <property type="gene designation" value="pgm-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_5_0_1"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012803">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86DA0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glucose 1,6-bisphosphate synthase"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="8">
        <location>
            <begin position="48"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="9">
        <location>
            <begin position="222"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD90182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y43F4B.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="Q86DA0"/>
        </source>
    </evidence>
    <sequence length="459" mass="51907" checksum="B4A7BC7109582D5C" modified="2003-06-01" version="1">MTLGCAKLDKQVADWLAWDKNDKNRNEIQKLVDEKNVDALKARMDTRLVFGTAGVRSPMQAGFGRLNDLTIIQITHGFARHMLNVYGQPKNGVAIGFDGRYNSRRFAELSANVFVRNNIPVYLFSEVSPTPVVSWATIKLGCDAGLIITASHNPKEDNGYKAYWSNGAQIIGPHDTEIVRIKEAEPQPRDEYWDLSELKSSPLFHSADVVIDPYFEVEKSLNFTREINGSTPLKFTYSAFHGIGYHYTKRMFAEFGFPASSFISVAEQQDPNPDFPTIPFPNPEEGRKVLTLAMETADKNGSTVILANDPDADRIQMAEKQKELQKRDHPDRIQMDGKSSRGAPCRWKSGHSGVGRIDRIHARAYHGQGRRVRCRSFRRNRRFPSRGGKIVARPAVRSLQSIWLPFGQIHLLDGTGSGGHQEALQHIESRSEVPDENRRSRSGIRERLDDRIRQLKARQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-02" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q94250-2</accession>
    <name>MBL_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Muscleblind-like protein</fullName>
            <shortName>CeMBL</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mbl-1</name>
        <name type="ORF">K02H8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Development" volume="124" first="4321" last="4331">
            <title>Muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins.</title>
            <authorList>
                <person name="Begemann G."/>
                <person name="Paricio N."/>
                <person name="Artero R."/>
                <person name="Kiss I."/>
                <person name="Perez-Alonso M."/>
                <person name="Mlodzik M."/>
            </authorList>
            <dbReference type="PubMed" id="9334280"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="J. Neurosci. Res." volume="87" first="1090" last="1097">
            <title>Identification of Caenorhabditis elegans K02H8.1 (CeMBL), a functional ortholog of mammalian MBNL proteins.</title>
            <authorList>
                <person name="Sasagawa N."/>
                <person name="Ohno E."/>
                <person name="Kino Y."/>
                <person name="Watanabe Y."/>
                <person name="Ishiura S."/>
            </authorList>
            <dbReference type="PubMed" id="19021294"/>
            <dbReference type="DOI" id="10.1002/jnr.21942"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>RNA-BINDING</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94250-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q94250-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_039465"/>
        </isoform>
        <isoform>
            <id>Q94250-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_039466"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001129931.1">
        <property type="nucleotide sequence ID" value="NM_001136459.4"/>
    </dbReference>
    <dbReference type="WormBase" id="K02H8.1b">
        <property type="protein sequence ID" value="CE42747"/>
        <property type="gene ID" value="WBGene00019347"/>
        <property type="gene designation" value="mbl-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="306" mass="33152" checksum="9F9FDA3A68203700" modified="2006-09-05" version="2">MFDENSNAAGTTPVASSLAATPNANLVSQVFNVKDSRWLQVEVCREFLRGQCARSDQECKFAHPPPNVDVQQGRVTACYDSIKGRCTRENPKCKYLHPPQHIKDQLLINGRNHLALKNLLSAQLNQTGTPMVNPMMALQQQAAAVNLIPNTPIYPPYYNGMMYPQVLQDPYTAAAVNQQLQTAALLGNVGGLLSAQSAAAFMANSSAAAAAAQQTPSPLLRLQRKRALEEENTNGNDMTSAAAAHTQLLSLAAGAVPMKRPTLDKNGAMLYSPVAQQAQQFNPYLLQTLQGYVPAVSCEYMQPPPF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-02" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q94250-3</accession>
    <name>MBL_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Muscleblind-like protein</fullName>
            <shortName>CeMBL</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mbl-1</name>
        <name type="ORF">K02H8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Development" volume="124" first="4321" last="4331">
            <title>Muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins.</title>
            <authorList>
                <person name="Begemann G."/>
                <person name="Paricio N."/>
                <person name="Artero R."/>
                <person name="Kiss I."/>
                <person name="Perez-Alonso M."/>
                <person name="Mlodzik M."/>
            </authorList>
            <dbReference type="PubMed" id="9334280"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="J. Neurosci. Res." volume="87" first="1090" last="1097">
            <title>Identification of Caenorhabditis elegans K02H8.1 (CeMBL), a functional ortholog of mammalian MBNL proteins.</title>
            <authorList>
                <person name="Sasagawa N."/>
                <person name="Ohno E."/>
                <person name="Kino Y."/>
                <person name="Watanabe Y."/>
                <person name="Ishiura S."/>
            </authorList>
            <dbReference type="PubMed" id="19021294"/>
            <dbReference type="DOI" id="10.1002/jnr.21942"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>RNA-BINDING</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94250-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_039466"/>
        </isoform>
        <isoform>
            <id>Q94250-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q94250-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_039465"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379924.1">
        <property type="nucleotide sequence ID" value="NM_001392916.1"/>
    </dbReference>
    <dbReference type="WormBase" id="K02H8.1c">
        <property type="protein sequence ID" value="CE42814"/>
        <property type="gene ID" value="WBGene00019347"/>
        <property type="gene designation" value="mbl-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="231" mass="25622" checksum="DD79B5992B9A2C9E" modified="2006-09-05" version="2">MFDENSNAAGTTPVASSLAATPNANLVSQVFNVKDSRWLQVEVCREFLRGQCARSDQECKFAHPPPNVDVQQGRVTACYDSIKGRCTRENPKCKYLHPPQHIKDQLLINGRNHLALKNLLSAQLNQTGTPMVNPMMALQQQAAAVNLIPNTPIYPPYYNGMMYPQVLQDPYTAAAVNQGAVPMKRPTLDKNGAMLYSPVAQQAQQFNPYLLQTLQGYVPAVSCEYMQPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N2V4</accession>
    <name>Q9N2V4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleckstrin homology domain-containing family G member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">prhg-1</name>
        <name evidence="4" type="ORF">CELE_Y95B8A.12</name>
        <name evidence="6" type="ORF">Y95B8A.12</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD73547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001032992.1">
        <property type="nucleotide sequence ID" value="NM_001037903.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N2V4"/>
    <dbReference type="SMR" id="Q9N2V4"/>
    <dbReference type="GeneID" id="190810"/>
    <dbReference type="KEGG" id="cel:CELE_Y95B8A.12"/>
    <dbReference type="UCSC" id="Y95B8A.12b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022391"/>
    <dbReference type="CTD" id="190810"/>
    <dbReference type="WormBase" id="Y95B8A.12a">
        <property type="protein sequence ID" value="CE31393"/>
        <property type="gene ID" value="WBGene00022391"/>
        <property type="gene designation" value="prhg-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030833_1_0_1"/>
    <dbReference type="OrthoDB" id="5585231at2759"/>
    <dbReference type="PhylomeDB" id="Q9N2V4"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022391">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N2V4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13245">
        <property type="entry name" value="PH_PLEKHG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040181">
        <property type="entry name" value="PKHG5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217:SF6">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16652">
        <property type="entry name" value="PH_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="185"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="433"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD73547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y95B8A.12a"/>
        </source>
    </evidence>
    <sequence length="621" mass="71777" checksum="530B08BB6E60FA97" modified="2002-10-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N2Z3</accession>
    <name>Q9N2Z3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">grl-16</name>
        <name evidence="4" type="ORF">CELE_Y65B4BR.6</name>
        <name evidence="6" type="ORF">Y65B4BR.6</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD71935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_490754.1">
        <property type="nucleotide sequence ID" value="NM_058353.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N2Z3"/>
    <dbReference type="SMR" id="Q9N2Z3"/>
    <dbReference type="GeneID" id="171649"/>
    <dbReference type="KEGG" id="cel:CELE_Y65B4BR.6"/>
    <dbReference type="UCSC" id="Y65B4BR.6a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001725"/>
    <dbReference type="CTD" id="171649"/>
    <dbReference type="WormBase" id="Y65B4BR.6a">
        <property type="protein sequence ID" value="CE25541"/>
        <property type="gene ID" value="WBGene00001725"/>
        <property type="gene designation" value="grl-16"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565300_0_0_1"/>
    <dbReference type="OrthoDB" id="5873773at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N2Z3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004330244" evidence="2">
        <location>
            <begin position="17"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="3">
        <location>
            <begin position="320"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD71935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N2Z3"/>
        </source>
    </evidence>
    <sequence length="393" mass="39109" checksum="F5BFAFA8B6440AB3" modified="2000-10-01" version="1">MRVLVAVLLAVSPALACIGGAGSAGGCCPPSQPSCGGGAPPCSSSSYATGGGGGSYAAAPALPPPPPPPPAPIGGGAGYAAPFGGPGPVGGASYSQGPQGFGGQVGGGAYQAGPGPIGGGASSHAGSQAGPSYAGASQAVGASSYARSQGPIGGGPSYAGASQPAPVAPQGGYNAGPSAPVEQVQQGGYQSGPVSSIQVTQVSQGGNYQAPPEHQAVQEIVAETEAPVVVAETEAPAVVETEAPVVIEETEAPVVVEETPAPVVEETQAPVAAAKEESTYDDIVEEQPSTATETATEQVDTVEETNEAVEYADEEGDEGNCDDPELRAIVEAALKNEKDNLEAARKIEGDASAKFGGRFNAIVSDAEFAYVNWYGKRNCQLRYENRHSLTWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N350</accession>
    <name>Q9N350_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_Y55F3BR.6</name>
        <name evidence="5 7" type="ORF">Y55F3BR.6</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD67293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N350"/>
    <dbReference type="SMR" id="Q9N350"/>
    <dbReference type="IntAct" id="Q9N350">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q9N350"/>
    <dbReference type="UCSC" id="Y55F3BR.6">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021943"/>
    <dbReference type="WormBase" id="Y55F3BR.6a">
        <property type="protein sequence ID" value="CE39864"/>
        <property type="gene ID" value="WBGene00021943"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091813_0_0_1"/>
    <dbReference type="OMA" id="TYEKRII"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="PhylomeDB" id="Q9N350"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021943">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N350">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="62"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD67293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y55F3BR.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N350"/>
        </source>
    </evidence>
    <sequence length="180" mass="19540" checksum="2EB8804420927876" modified="2006-11-28" version="3">MATFNTTSSYNRTYEKKVIEEGSPNVRVTTQTHTAIPGMPDLGNIHSSMLSNFPNLAISSPSVVGSQNGNLTSIRVTNTSFHAILDVSKYDADSLKVTVVDNNIIVEGSHGEKEDTYGTIESTFKRRFPLPKAVAPESVQSQLTADGHLTIDAKAPEPKQEGARPIQIKVINTSAEQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N391</accession>
    <name>Q9N391_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASD2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">B0353.1</name>
        <name evidence="2" type="ORF">CELE_B0353.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379570.1">
        <property type="nucleotide sequence ID" value="NM_001393257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N391"/>
    <dbReference type="SMR" id="Q9N391"/>
    <dbReference type="IntAct" id="Q9N391">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q9N391"/>
    <dbReference type="GeneID" id="175209"/>
    <dbReference type="UCSC" id="Y55B1AL.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00015155"/>
    <dbReference type="CTD" id="175209"/>
    <dbReference type="WormBase" id="B0353.1e">
        <property type="protein sequence ID" value="CE25471"/>
        <property type="gene ID" value="WBGene00015155"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1241107_0_0_1"/>
    <dbReference type="OMA" id="DLECAMV"/>
    <dbReference type="OrthoDB" id="10063560at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015155">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N391">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD61808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="B0353.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N391"/>
        </source>
    </evidence>
    <sequence length="223" mass="25866" checksum="3E672CBA1B9EE8B2" modified="2000-10-01" version="1">MTSLSSPSPIQHTTSSFLNNFMPTPSLINLQQGYRNPDLGSQDLARLDASRHESIQKVSRKLSTYEEEKNLIENELEEIERTGARLLSIVEQKDNFLASRIRRFMEKSKELVGIETLLRLQLNKHNERIKDGLIDISAARGEESYLQKRFKDTDFLRKISARREIDYDKELSEIFTDDQFHRWVMFKKATLQLLQTESSVSYYIRESNAKLDALHLAPRGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>U4PFD5</accession>
    <name>U4PFD5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LIn-26 Related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">lir-1</name>
        <name evidence="1" type="ORF">CELE_F18A1.3</name>
        <name evidence="3" type="ORF">F18A1.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293591.1">
        <property type="nucleotide sequence ID" value="NM_001306662.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PFD5"/>
    <dbReference type="SMR" id="U4PFD5"/>
    <dbReference type="GeneID" id="174240"/>
    <dbReference type="AGR" id="WB:WBGene00003044"/>
    <dbReference type="CTD" id="174240"/>
    <dbReference type="WormBase" id="F18A1.3i">
        <property type="protein sequence ID" value="CE48809"/>
        <property type="gene ID" value="WBGene00003044"/>
        <property type="gene designation" value="lir-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5775637at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003044">
        <property type="expression patterns" value="Expressed in embryo and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PFD5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F18A1.3i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="U4PFD5"/>
        </source>
    </evidence>
    <sequence length="297" mass="33917" checksum="6076823C0C12ED00" modified="2013-12-11" version="1">MPKFVVIELNDDAATIDLLSYCVKKNFERVSLLTRLEDHPYLRDDQDVVQDDTQSQGTDGMLLQLNDEERQRLMKMISTPGPQTLSMERIQMAPGQGQHILQQHQIPSTSSYTNNSFIYIKSDPQYKDEPQQQSNQFDATVNSVAHGQAGLSTLEMFACNGSPNGGDVLRRKTPSRKAEDSIKATCKVCGHDVMYSPQRTWNLMRHVWIMHQSSKPNQCSICGYSHIKPYVRKHIESQHKHDSNATIIDLKSPELEAEWSQLLDQCFGVTYRKWKHHKEDTQHTGGLLFDDDELRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6RT83</accession>
    <name>W6RT83_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 35 member F1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CELE_Y73E7A.3</name>
        <name evidence="9 11" type="ORF">Y73E7A.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative solute transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RT83"/>
    <dbReference type="SMR" id="W6RT83"/>
    <dbReference type="AGR" id="WB:WBGene00022270"/>
    <dbReference type="WormBase" id="Y73E7A.3d">
        <property type="protein sequence ID" value="CE49483"/>
        <property type="gene ID" value="WBGene00022270"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039639_5_1_1"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022270">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RT83">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM63462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y73E7A.3d"/>
        </source>
    </evidence>
    <sequence length="238" mass="26049" checksum="A726ABB558D0DD96" modified="2014-04-16" version="1">MPTKDYSEIRRTFKALILGQILSLCLCGTGVSSQLLVNQNVNAPAAQAFSNYFLLCFVYCISLACKNDENGLVVVLRKRGWRYLILAIIDVEANYMIVKAYQYTNLTSVQLLDCATIPTVLFLSWLFLSVRYLASHILGVTICIIGIACVIWADALGDKGALDGGSNKVLGDILCLAAAVMYAICNVAEEFLVKQHSRTEYLGMLGLFGCIVSGVQTGPSMTFVLWNLIGQKSVIVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>X5MBH0</accession>
    <name>X5MBH0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">grif-1</name>
        <name evidence="1" type="ORF">CELE_Y51F10.2</name>
        <name evidence="3" type="ORF">Y51F10.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDO50121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368469.1">
        <property type="nucleotide sequence ID" value="NM_001381324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="X5MBH0"/>
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    <dbReference type="CTD" id="245998"/>
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        <property type="protein sequence ID" value="CE49624"/>
        <property type="gene ID" value="WBGene00021763"/>
        <property type="gene designation" value="grif-1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021763">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="X5MBH0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO50121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y51F10.2c"/>
        </source>
    </evidence>
    <sequence length="126" mass="15064" checksum="BDCF28C55437B005" modified="2014-06-11" version="1">MQRQENQRRIVGLQDNLHKVQRDFREQLNATMERWAGWNGSHDLSMDKFRELGDTYNQKKVYDAFVHQLRGKTAKIEKLAEHVLRWNDELDREMERPPAHRLPRSSTPAPAPPFDNSVAYYFEHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>X5MBH3</accession>
    <name>X5MBH3_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">spe-48</name>
        <name evidence="3" type="ORF">CELE_Y51F10.10</name>
        <name evidence="5" type="ORF">Y51F10.10</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001306469.2"/>
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    <dbReference type="AlphaFoldDB" id="X5MBH3"/>
    <dbReference type="SMR" id="X5MBH3"/>
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    <dbReference type="KEGG" id="cel:CELE_Y51F10.10"/>
    <dbReference type="AGR" id="WB:WBGene00021771"/>
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    <dbReference type="WormBase" id="Y51F10.10b">
        <property type="protein sequence ID" value="CE49708"/>
        <property type="gene ID" value="WBGene00021771"/>
        <property type="gene designation" value="spe-48"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_824469_0_0_1"/>
    <dbReference type="OrthoDB" id="5824432at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021771">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="X5MBH3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038870">
        <property type="entry name" value="UBAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960:SF5">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="263"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDO50126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y51F10.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="X5MBH3"/>
        </source>
    </evidence>
    <sequence length="312" mass="35522" checksum="05ED1DFE2F33F1FB" modified="2014-06-11" version="1">MSFNDVFHDYIKDIPMDISRKFYPTRNINVDFIQIPDLRFTKFEYSFEAETRAREQFDKQNEPIVLDSTSTKTTTTASPPGGNKNSGEVRTSESRQSVSGYDDVLSQNVLVPCPVNSNPSMTSSSTKPSVSNTSAMVHSLHEFESTNNVFDDIQILALDDRKALQEQQKQHEPINNNNNTEMKPKKLEKAEKTAKNSDQQQHEELRKRLLTKGYRADIVEKALRCLPKSRLVHIEYYMKACRTVEKTGKSSIDETLPFLIQCNLSDKMVILSYSEVCSNLLKMGFPRPQIFEAVAVEKGDQNRALSRLLPNS</sequence>
</entry>
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    <accession>A0A078BQL6</accession>
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        <submittedName>
            <fullName evidence="1">BH4_AAA_HYDROXYL_2 domain-containing protein</fullName>
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        <name evidence="1" type="ORF">CELE_F38C2.1</name>
        <name evidence="1 3" type="ORF">F38C2.1</name>
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    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294105.1">
        <property type="nucleotide sequence ID" value="NM_001307176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BQL6"/>
    <dbReference type="GeneID" id="185459"/>
    <dbReference type="AGR" id="WB:WBGene00009535"/>
    <dbReference type="CTD" id="185459"/>
    <dbReference type="WormBase" id="F38C2.1d">
        <property type="protein sequence ID" value="CE50005"/>
        <property type="gene ID" value="WBGene00009535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009535">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BQL6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDX47470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F38C2.1d"/>
        </source>
    </evidence>
    <sequence length="23" mass="2636" checksum="2AB6013D22E7910E" modified="2014-10-29" version="1">MSNVGYISTFNWRTSAPVFLDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BQM0</accession>
    <name>A0A078BQM0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y65A5A.1</name>
        <name evidence="2 4" type="ORF">Y65A5A.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294110.1">
        <property type="nucleotide sequence ID" value="NM_001307181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BQM0"/>
    <dbReference type="SMR" id="A0A078BQM0"/>
    <dbReference type="GeneID" id="178456"/>
    <dbReference type="KEGG" id="cel:CELE_Y65A5A.1"/>
    <dbReference type="AGR" id="WB:WBGene00013418"/>
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    <dbReference type="WormBase" id="Y65A5A.1b">
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        <property type="gene ID" value="WBGene00013418"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5816200at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013418">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BQM0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y65A5A.1b"/>
        </source>
    </evidence>
    <sequence length="74" mass="8128" checksum="BA67DF40FB9D6416" modified="2014-10-29" version="1">MLPVSPKNCDPADVVLRAASYIDQLVATVQARVKNGTLPMGALSSLPPQYSKPIKSSRRTVSSKKSRRSMEKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BQN0</accession>
    <name>A0A078BQN0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUEL-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">B0207.5</name>
        <name evidence="3" type="ORF">CELE_B0207.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293386.1">
        <property type="nucleotide sequence ID" value="NM_001306457.2"/>
    </dbReference>
    <dbReference type="GeneID" id="172266"/>
    <dbReference type="KEGG" id="cel:CELE_B0207.5"/>
    <dbReference type="AGR" id="WB:WBGene00015028"/>
    <dbReference type="CTD" id="172266"/>
    <dbReference type="WormBase" id="B0207.5a">
        <property type="protein sequence ID" value="CE50098"/>
        <property type="gene ID" value="WBGene00015028"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5809853at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015028">
        <property type="expression patterns" value="Expressed in material anatomical entity and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BQN0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001730243" evidence="2">
        <location>
            <begin position="21"/>
            <end position="3654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CDX47487.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="B0207.5a"/>
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    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BQN0"/>
        </source>
    </evidence>
    <sequence length="3654" mass="423786" checksum="AB5E3CE344CFB2D9" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BQP7</accession>
    <name>A0A078BQP7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
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        <name evidence="7" type="ORF">CELE_Y105C5B.15</name>
        <name evidence="7 9" type="ORF">Y105C5B.15</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
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    </dbReference>
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        <property type="entry name" value="Purple_acid_Pase-like_N"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <begin position="2"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDX47502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y105C5B.15b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BQP7"/>
        </source>
    </evidence>
    <sequence length="364" mass="41705" checksum="3D1BE940CC54A6ED" modified="2014-10-29" version="1">MYGLSKDALRWTAKATTTSWKDQGSHGYVRYTHRATMTKMVPGDTYYYKVGSSQDMSDVYHFHQPDPTQPLRAAIFGDLSVYKGAPSIKQLTDATHDNHFDVIIHIGDIAYDLHDDEGNRGDDYMNAVQPFAAYVPYMVFAGNHESDSHFNQIINRFTMPKNGVYDNNLFWSFDYGLTHFIGLNSEYYAEIHTKEAQAQYKWLQADLAKNKAQWTIVMFHRPWYCSTKDKGGCNDYLDMLSRKGNSELPGLEKLLFDHKVDMVLYGHKHTYERMWPIYDGTGYKSSDSGHIRNAKAPVYILTGSAGCHTHEGPSDAPQSFSATRLGQYGYTRLKVYNTTHLSTYFVDTSDKVGNFMDKFYLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BQQ1</accession>
    <name>A0A078BQQ1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">jac-1</name>
        <name evidence="9" type="ORF">CELE_Y105C5B.21</name>
        <name evidence="11" type="ORF">Y105C5B.21</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294126.1">
        <property type="nucleotide sequence ID" value="NM_001307197.4"/>
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    <dbReference type="GeneID" id="178451"/>
    <dbReference type="AGR" id="WB:WBGene00002175"/>
    <dbReference type="CTD" id="178451"/>
    <dbReference type="WormBase" id="Y105C5B.21h">
        <property type="protein sequence ID" value="CE49998"/>
        <property type="gene ID" value="WBGene00002175"/>
        <property type="gene designation" value="jac-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002175">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BQQ1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Bent, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Juxtamembrane domain-associated catenin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF27">
        <property type="entry name" value="ADHERENS JUNCTION PROTEIN P120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SPS41589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F39D8.1d"/>
        </source>
    </evidence>
    <sequence length="742" mass="79580" checksum="2F1D680F9B980576" modified="2018-09-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-10-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A565CXP8</accession>
    <name>A0A565CXP8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear hormone receptor family member nhr-62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">nhr-62</name>
        <name evidence="15" type="ORF">CELE_Y67A6A.2</name>
        <name evidence="17" type="ORF">Y67A6A.2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="VVB27839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360798.1">
        <property type="nucleotide sequence ID" value="NM_001373584.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A565CXP8"/>
    <dbReference type="SMR" id="A0A565CXP8"/>
    <dbReference type="GeneID" id="172836"/>
    <dbReference type="AGR" id="WB:WBGene00003652"/>
    <dbReference type="CTD" id="172836"/>
    <dbReference type="WormBase" id="Y67A6A.2c">
        <property type="protein sequence ID" value="CE53661"/>
        <property type="gene ID" value="WBGene00003652"/>
        <property type="gene designation" value="nhr-62"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817395at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A565CXP8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052499">
        <property type="entry name" value="C.elegans_NHRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630:SF4">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="225"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VVB27839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="Y67A6A.2c"/>
        </source>
    </evidence>
    <sequence length="512" mass="57726" checksum="DA3EE8ECE3710C3F" modified="2019-10-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I7J7</accession>
    <name>A0A8D9I7J7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">clh-1</name>
        <name evidence="12" type="ORF">CELE_T27D12.2</name>
        <name evidence="14" type="ORF">T27D12.2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAG8860240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001382723.1">
        <property type="nucleotide sequence ID" value="NM_001395813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9I7J7"/>
    <dbReference type="SMR" id="A0A8D9I7J7"/>
    <dbReference type="GeneID" id="174821"/>
    <dbReference type="AGR" id="WB:WBGene00000528"/>
    <dbReference type="CTD" id="174821"/>
    <dbReference type="WormBase" id="T27D12.2g">
        <property type="protein sequence ID" value="CE54389"/>
        <property type="gene ID" value="WBGene00000528"/>
        <property type="gene designation" value="clh-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015108">
        <property type="term" value="F:chloride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03683">
        <property type="entry name" value="ClC_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000020">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000044">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000050">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF5">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="568"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="828"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG8860240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T27D12.2g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8D9I7J7"/>
        </source>
    </evidence>
    <sequence length="861" mass="96313" checksum="D26C568D4E10A9C8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I7K9</accession>
    <name>A0A8D9I7K9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T26A5.2</name>
        <name evidence="2 4" type="ORF">T26A5.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAG8860255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9I7K9"/>
    <dbReference type="AGR" id="WB:WBGene00020819"/>
    <dbReference type="WormBase" id="T26A5.2g">
        <property type="protein sequence ID" value="CE54344"/>
        <property type="gene ID" value="WBGene00020819"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5833282at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG8860255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T26A5.2g"/>
        </source>
    </evidence>
    <sequence length="842" mass="96836" checksum="1B73FA520FF2BDB8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>A1Z6D3</accession>
    <name>A1Z6D3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate exchanger 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 37 member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CELE_T11G6.2</name>
        <name evidence="12 14" type="ORF">T11G6.2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAM06585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001076703.1">
        <property type="nucleotide sequence ID" value="NM_001083234.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1Z6D3"/>
    <dbReference type="SMR" id="A1Z6D3"/>
    <dbReference type="PeptideAtlas" id="A1Z6D3"/>
    <dbReference type="GeneID" id="177977"/>
    <dbReference type="UCSC" id="T11G6.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011717"/>
    <dbReference type="CTD" id="177977"/>
    <dbReference type="WormBase" id="T11G6.2b">
        <property type="protein sequence ID" value="CE06428"/>
        <property type="gene ID" value="WBGene00011717"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_31_6_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011717">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A1Z6D3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17342">
        <property type="entry name" value="MFS_SLC37A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF12">
        <property type="entry name" value="SUGAR PHOSPHATE EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="31"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAM06585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T11G6.2b"/>
        </source>
    </evidence>
    <sequence length="495" mass="55386" checksum="86E6C072303DBC4C" modified="2007-02-06" version="1">MPRIRLRNDVSSSSFWTRITGQKWSKHHVFIFVHTFMSYAMLHATRKTLSTVKPSLIHTWISNTSTPDGPVFPSQQAAAEFLGVLDTGFLVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYSPMVYSFLWILNGFIQSVGWPVEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASYTLFLGYQYSFLIACSLLFIYSFLVFFQLPSAPWEVSSDILPEQMEEEETDDEPTERPPPIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLHAGLHWPESYADSLSTWYDVGGIVAAVLAGAFSDHMRSRTPVVFIMLLMATVSLYIYAHSPESYNWNAFLLLVAGFFIGGPANMISSSITADLGKCDQLRGNAEALSTVTGIIDGTGSIGAAIGQWFIPSVQHWFGWDAVFYGFIVMILCTALCLVPVLWKEHKERRIHRSEEVDSLLQSDSDENLADDIQEIRRRPTNAIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPJ2-2</accession>
    <name>CEH63_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Homeobox protein ceh-63</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ceh-63</name>
        <name evidence="4" type="ORF">C02F12.10</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2012" name="Gene" volume="494" first="73" last="84">
            <title>A regulatory cascade of three transcription factors in a single specific neuron, DVC, in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Feng H."/>
                <person name="Reece-Hoyes J.S."/>
                <person name="Walhout A.J."/>
                <person name="Hope I.A."/>
            </authorList>
            <dbReference type="PubMed" id="22207033"/>
            <dbReference type="DOI" id="10.1016/j.gene.2011.11.042"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CEH-14</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A3FPJ2-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061132"/>
        </isoform>
        <isoform>
            <id>A3FPJ2-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001364844.1">
        <property type="nucleotide sequence ID" value="NM_001377614.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C02F12.10b">
        <property type="protein sequence ID" value="CE50485"/>
        <property type="gene ID" value="WBGene00045215"/>
        <property type="gene designation" value="ceh-63"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="22207033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C02F12.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C02F12.10b"/>
        </source>
    </evidence>
    <sequence length="46" mass="5346" checksum="BC4A22743452FFC0" modified="2007-03-20" version="1">MMKKSDERSPSPQNPSSQHVQNLQTFFHSWPSHFAYSLPSDQQNNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>A5JYW9-2</accession>
    <name>SIN3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Paired amphipathic helix protein sin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Histone deacetylase complex subunit sin-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptional corepressor sin-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sin-3</name>
        <name evidence="2" type="synonym">pqn-28</name>
        <name evidence="6" type="ORF">F02E9.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="PLoS Genet." volume="2" first="E74" last="E74">
            <title>Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.</title>
            <authorList>
                <person name="Cui M."/>
                <person name="Kim E.B."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="16710447"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.0020074"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Biochem. Biophys. Res. Commun." volume="358" first="802" last="807">
            <title>C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development.</title>
            <authorList>
                <person name="Choy S.W."/>
                <person name="Wong Y.-M."/>
                <person name="Ho S.H."/>
                <person name="Chow K.L."/>
            </authorList>
            <dbReference type="PubMed" id="17506990"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2007.04.194"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002267" last="E1002267">
            <title>Caenorhabditis elegans histone methyltransferase MET-2 shields the male X chromosome from checkpoint machinery and mediates meiotic sex chromosome inactivation.</title>
            <authorList>
                <person name="Checchi P.M."/>
                <person name="Engebrecht J."/>
            </authorList>
            <dbReference type="PubMed" id="21909284"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002267"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="0" last="0">
            <title>A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes.</title>
            <authorList>
                <person name="Lee J."/>
                <person name="Taylor C.A."/>
                <person name="Barnes K.M."/>
                <person name="Shen A."/>
                <person name="Stewart E.V."/>
                <person name="Chen A."/>
                <person name="Xiang Y.K."/>
                <person name="Bao Z."/>
                <person name="Shen K."/>
            </authorList>
            <dbReference type="PubMed" id="31386623"/>
            <dbReference type="DOI" id="10.7554/elife.46703"/>
        </citation>
        <scope>INTERACTION WITH ZTF-11</scope>
    </reference>
    <reference evidence="3" key="6">
        <citation type="journal article" date="2019" name="Nucleic Acids Res." volume="47" first="11164" last="11180">
            <title>Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans.</title>
            <authorList>
                <person name="Beurton F."/>
                <person name="Stempor P."/>
                <person name="Caron M."/>
                <person name="Appert A."/>
                <person name="Dong Y."/>
                <person name="Chen R.A."/>
                <person name="Cluet D."/>
                <person name="Coute Y."/>
                <person name="Herbette M."/>
                <person name="Huang N."/>
                <person name="Polveche H."/>
                <person name="Spichty M."/>
                <person name="Bedet C."/>
                <person name="Ahringer J."/>
                <person name="Palladino F."/>
            </authorList>
            <dbReference type="PubMed" id="31602465"/>
            <dbReference type="DOI" id="10.1093/nar/gkz880"/>
        </citation>
        <scope>IDENTIFICATION IN THE SIN3S COMPLEX</scope>
        <scope>INTERACTION WITH CFP-1</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A5JYW9-1</id>
            <name evidence="6">b</name>
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        <isoform>
            <id>A5JYW9-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_058573"/>
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    <dbReference type="RefSeq" id="NP_492284.2">
        <property type="nucleotide sequence ID" value="NM_059883.5"/>
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    <dbReference type="WormBase" id="F02E9.4a">
        <property type="protein sequence ID" value="CE33046"/>
        <property type="gene ID" value="WBGene00004117"/>
        <property type="gene designation" value="sin-3"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O75182"/>
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    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="17506990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F02E9.4a"/>
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    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F02E9.4b"/>
        </source>
    </evidence>
    <sequence length="1505" mass="171497" checksum="C3273743FC0EFD51" modified="2007-06-26" version="1"> </sequence>
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    <accession>A9UJP1</accession>
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        <submittedName>
            <fullName evidence="8">MARVEL domain-containing protein</fullName>
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    <gene>
        <name evidence="8" type="ORF">CELE_K09G1.1</name>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAP59529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A9UJP1"/>
    <dbReference type="PeptideAtlas" id="A9UJP1"/>
    <dbReference type="AGR" id="WB:WBGene00010727"/>
    <dbReference type="WormBase" id="K09G1.1c">
        <property type="protein sequence ID" value="CE42012"/>
        <property type="gene ID" value="WBGene00010727"/>
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        <property type="component" value="Chromosome V"/>
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    <dbReference type="Bgee" id="WBGene00010727">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A9UJP1">
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    </dbReference>
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        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
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    <dbReference type="PANTHER" id="PTHR22776:SF52">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="159"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="193"/>
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    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="87"/>
            <end position="221"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAP59529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="K09G1.1c"/>
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    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A9UJP1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26183" checksum="3E9D10156F0DF828" modified="2008-02-05" version="1">MITHLPASRLEDYYLTSILGEVRRAAASFQENPQEDGKMSETEIITIRKPDGTTETKTVEKKKLQFHMANKVKIIPTNRQGQLNTGYLATLAGVLKIAEIVLSFIAFILAICADRRTTTAAWTEHISFETLLIVSALLLGYVVFPHLTIKDEATREGLIVVELIFYGVNTLLYFISIWLMVHLSASWGTDGRGAAIMTAVICVALTVLFAIETVVKLKAWRGENEPTTVIEAGNAQA</sequence>
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            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
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    <organism evidence="7 8">
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="183513"/>
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    <dbReference type="AGR" id="WB:WBGene00001175"/>
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        <property type="gene ID" value="WBGene00001175"/>
        <property type="gene designation" value="egl-6"/>
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    <dbReference type="HOGENOM" id="CLU_009579_24_4_1"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD67506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C46F4.1b"/>
        </source>
    </evidence>
    <sequence length="384" mass="44787" checksum="368CD18510D94077" modified="2009-03-03" version="1">MNDTLICTYFECYIHMFAMYYDEIHIPLSISICIFGAASNVFNIIVLTRKRMRTPINILLTGLSIAQWLLATNYFLYLLLEYYRYQCVQLLWSEAFTRYRFFNVNLNTVFHTIAFTTTIVVAVFRYCALKFPIQANRFIYKCQPAIAANVIIWIIIPIISLPLFFISEVKIVARDHVAYDLQCEMEGPLYDLSYQESPLLVSAVFWAFGIVFKLLPSLILSILLIALIRSLKSVERRRKNWKRTQGANICTNSERKAKRKLTTRPRTTRMLVIILLLCVMVELPMGILNLCVAIYGEEFGNRYYDPVGNLMEMLTLLYSSVSFVLYCTMSNEYLSTFRALFFPWTRKNSLRGTRRSWNHRHDDETKSPRTFLINRTAPSSYVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-02-09" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>D2KT99</accession>
    <name>D2KT99_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">szy-20</name>
        <name evidence="5" type="ORF">C18E9.3</name>
        <name evidence="3" type="ORF">CELE_C18E9.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CBI68023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254188.1">
        <property type="nucleotide sequence ID" value="NM_001267259.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D2KT99"/>
    <dbReference type="SMR" id="D2KT99"/>
    <dbReference type="GeneID" id="174430"/>
    <dbReference type="AGR" id="WB:WBGene00004105"/>
    <dbReference type="CTD" id="174430"/>
    <dbReference type="WormBase" id="C18E9.3g">
        <property type="protein sequence ID" value="CE44364"/>
        <property type="gene ID" value="WBGene00004105"/>
        <property type="gene designation" value="szy-20"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515108_0_0_1"/>
    <dbReference type="OrthoDB" id="5373615at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004105">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D2KT99">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010824">
        <property type="term" value="P:regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="48"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBI68023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C18E9.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D2KT99"/>
        </source>
    </evidence>
    <sequence length="460" mass="52613" checksum="87BF15DDAF94A83C" modified="2010-02-09" version="1">MSKENVSLVVADSWDDADADPVKELMDKVEKVKLLQRKEEKKEAFFEKVKAEESSGVVSKLQTEEGLGPSAEEPKRVFLRRPKDGFAASENVIEASPPTSADTEEQPVTNVRSRSHHKLNQKEKQPAPTYEERQAAYQAARNRILGTEYKPDNQEIKEIKFIDRSKSPETLKMTQQNMVEHYGEELSRELMEQPAEIVPPERQYTPDFTNYIPYNLPNMAYPPPNFQPQGQLHHQMNAGQLHQIQQQQQQCQQIQHQPPQQHQQVINGQVMNQQNQRNQVNSYPQQNGAGRGQNRQPMMYQMPCNSGPTAKPPPLMNQMQNRCMTNNGQNYQNRNMQQQGQQRSYSSQPQNGQFYQNGNSNQNNPNNGRKQQHQPQQQQNKSGKFGQNRNDMQKNNYQPNLQQPPMSQNPIPFGCPPRNVNAIREQHANNGSPNTGAGILGPHPMMSASQWPALQQNRPQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-11-08" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>G5EBX4-2</accession>
    <name>JKAMP_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of JNK1/MAPK8-associated membrane protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">JAMP (JNK1-Associated Membrane Protein) homolog</fullName>
            <shortName evidence="1">JAMP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">jamp-1</name>
        <name evidence="3" type="synonym">5G528</name>
        <name evidence="5" type="ORF">R01B10.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2000-08" db="EMBL/GenBank/DDBJ databases">
            <title>The Caenorhabditis elegans transcriptome project, a complementary view of the genome.</title>
            <authorList>
                <person name="Kohara Y."/>
                <person name="Shin'i T."/>
                <person name="Suzuki Y."/>
                <person name="Sugano S."/>
                <person name="Potdevin M."/>
                <person name="Thierry-Mieg Y."/>
                <person name="Thierry-Mieg D."/>
                <person name="Thierry-Mieg J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="5019" last="5028">
            <title>JAMP optimizes ERAD to protect cells from unfolded proteins.</title>
            <authorList>
                <person name="Tcherpakov M."/>
                <person name="Broday L."/>
                <person name="Delaunay A."/>
                <person name="Kadoya T."/>
                <person name="Khurana A."/>
                <person name="Erdjument-Bromage H."/>
                <person name="Tempst P."/>
                <person name="Qiu X.-B."/>
                <person name="DeMartino G.N."/>
                <person name="Ronai Z."/>
            </authorList>
            <dbReference type="PubMed" id="18784250"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-08-0839"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EBX4-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EBX4-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_061983 VSP_061984"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001360559.1">
        <property type="nucleotide sequence ID" value="NM_001373030.1"/>
    </dbReference>
    <dbReference type="WormBase" id="R01B10.5b">
        <property type="protein sequence ID" value="CE52972"/>
        <property type="gene ID" value="WBGene00019807"/>
        <property type="gene designation" value="jamp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="18784250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAG50232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="R01B10.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="R01B10.5b"/>
        </source>
    </evidence>
    <sequence length="305" mass="34252" checksum="6D0A34AE8DE7B7DF" modified="2011-12-14" version="1">MSSLSGHASTIQPSCLGFCGRTVLVGNYSEDVEATTTAAGSTSLSRCGPCSFGYRNNAMSICESCDTPLQPYDWMYLLFIALLPLLLHMQFIRIARKYCRTRYYEVSEYLCVILENVIACVIAVLIYPPRFTFFLNGCSKTDIKEWYPACYNPRIGYTKTMRCTYEVVFPLYSITFIHHLILIGSILVLRSTLYCVLLYKTYNGKPFYAAIVSVPILAVIHAVLSGVVFYTFPYILLIGSLWAMCFHLALEGKRPLKEMIVRIATSPTHLIFLSITMLMLSFGVIAIIAPLIIPETSHTVGHSFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-08-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>G5EGQ2-2</accession>
    <name>PZF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Isoform b of Paired zinc finger protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pzf-1</name>
        <name evidence="4" type="ORF">T05G11.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2006" name="PLoS Genet." volume="2" first="e174" last="e174">
            <title>Expression profiling of MAP kinase-mediated meiotic progression in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Leacock S.W."/>
                <person name="Reinke V."/>
            </authorList>
            <dbReference type="PubMed" id="17096596"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.0020174"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EGQ2-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EGQ2-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061536"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001256689.1">
        <property type="nucleotide sequence ID" value="NM_001269760.3"/>
    </dbReference>
    <dbReference type="WormBase" id="T05G11.1b">
        <property type="protein sequence ID" value="CE45365"/>
        <property type="gene ID" value="WBGene00011505"/>
        <property type="gene designation" value="pzf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="17096596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T05G11.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T05G11.1b"/>
        </source>
    </evidence>
    <sequence length="469" mass="52857" checksum="EC5473927DA1A399" modified="2011-12-14" version="1">MTCHMCLLCNRRIPENETLREHMKNKHNIWKLFICVCCNWSFGTEIYLKCHEECMKSTGRPGLLKPLAMPMTAPAREASALNTDPQNGSDDVPHSSPSPVPMIAENSIIQASSLKMEPIESADRSSASTSTPRTLVSGTPREKIPCGFCGKDFFHEGSLREHRRRFHMTGHTCLLCNRQIPENETVRDHMKSQHNIKKVYNCLCCNWTFLNQVHLISHKTCLKQTGKPCCRPGHMEPLAIPRTASIRQFFTLKTETQSGDDDSAAGSQLFSARLSCKSCGKFFYSERSLSKHHRQIHMSGHVCVLCNHQMPKTVTVQEHMEKEHNIRLVFNCRCCNWSFATRRCLMSHVECLKKAGDARNVKPVAIPRMAADSILQSLKESEAQEYPDFSAASTTSSGPASTLKTPRMDFKKNLKICTDAVQILVGNGLFSNEQLAQTETWVMIFSNANKLFHSMNSFGEPSVSRDIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G8JXY3</accession>
    <name>G8JXY3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LUC7 related splicing factor homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">luc-7l</name>
        <name evidence="2" type="synonym">luc-7L</name>
        <name evidence="4" type="ORF">B0495.8</name>
        <name evidence="2" type="ORF">CELE_B0495.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741026.1">
        <property type="nucleotide sequence ID" value="NM_171023.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JXY3"/>
    <dbReference type="PeptideAtlas" id="G8JXY3"/>
    <dbReference type="GeneID" id="174246"/>
    <dbReference type="AGR" id="WB:WBGene00015207"/>
    <dbReference type="CTD" id="174246"/>
    <dbReference type="WormBase" id="B0495.8b">
        <property type="protein sequence ID" value="CE29949"/>
        <property type="gene ID" value="WBGene00015207"/>
        <property type="gene designation" value="luc-7L"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2760117_0_0_1"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015207">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JXY3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD61477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="B0495.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="G8JXY3"/>
        </source>
    </evidence>
    <sequence length="70" mass="7959" checksum="66D04D1AADBAEF32" modified="2012-01-25" version="1">MTDQMRDMIAQLMGSQHVDNKEKPSMPFDHHSVCRAFLLGVCPHDMVPDSRLQVPPQVLRAYRKPSAKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G8JXY4</accession>
    <name>G8JXY4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="ORF">B0244.4</name>
        <name evidence="10" type="ORF">CELE_B0244.4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254930.1">
        <property type="nucleotide sequence ID" value="NM_001268001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JXY4"/>
    <dbReference type="GeneID" id="181875"/>
    <dbReference type="AGR" id="WB:WBGene00015079"/>
    <dbReference type="CTD" id="181875"/>
    <dbReference type="WormBase" id="B0244.4c">
        <property type="protein sequence ID" value="CE46437"/>
        <property type="gene ID" value="WBGene00015079"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047461_1_0_1"/>
    <dbReference type="OrthoDB" id="5790882at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015079">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040435">
        <property type="entry name" value="Put_GPCR_Chromadorea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37441:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR B0244.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37441">
        <property type="entry name" value="PROTEIN CBG16518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD61510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="B0244.4c"/>
        </source>
    </evidence>
    <sequence length="296" mass="33565" checksum="BF26FF3986F21D9C" modified="2012-01-25" version="1">MANIFENCSYHSPYEPYYLNCTNTTNQCTLVQDVETIESIIFWIDFLIPCTLFVVACFLNAYYLSILVPEFTEMNDITKKQYIFMVSRAISALTACVIMLALRILQLITSSFTIYFLFFLIDDLSFYSLLGSYVGSAILLYLATIRPILYSNRISVRTVYKFAIANLITSVVLAIGDFTTDNSVSKSARTRLAWTLFTFTLITLTEAIPSFYLVGTSIDSSMIICSNFYKADHLIVPFTMNSLKTLAWAIALNVDPLCSLLFDPRIRKVWVQHTEKLKLVIQNTICGFSSTKSSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>G8JXY5</accession>
    <name>G8JXY5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="ORF">B0252.3</name>
        <name evidence="7" type="ORF">CELE_B0252.3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021889.1">
        <property type="nucleotide sequence ID" value="NM_001026718.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JXY5"/>
    <dbReference type="SMR" id="G8JXY5"/>
    <dbReference type="PeptideAtlas" id="G8JXY5"/>
    <dbReference type="GeneID" id="174130"/>
    <dbReference type="AGR" id="WB:WBGene00015088"/>
    <dbReference type="CTD" id="174130"/>
    <dbReference type="WormBase" id="B0252.3c">
        <property type="protein sequence ID" value="CE30586"/>
        <property type="gene ID" value="WBGene00015088"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_33_4_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015088">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JXY5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="29"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD61540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="B0252.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="G8JXY5"/>
        </source>
    </evidence>
    <sequence length="464" mass="51437" checksum="076C06E68352F7B6" modified="2012-01-25" version="1">MSSSDKLSADDVLNTLDKSNRHILTCILVCGLAWSPLAFTGLCPSFVVKASENSSFIGVADEFDLTGDASWLAESTTTFYMVGNMIGGMFIPPLADHYGRLPVFVATVLLMAVGGMISAFSTSIMMFCIMRMIHGIFYTAAGLAGWVLGYENTPLRLRFFTSVYFGVMWVVGACFLGLLAYILPDWRYLMFCISVPNIFVALLIYMTVPESLHFLVSSQQNEKIEAWLEKIRGPKGDISASDIVEDRDENGSSFKTLCREMWKHKMFIVYVLVMTYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRKVLISGTHIIAGLSFLGIVLSSEAWHIHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLSHLTAVHALAPAITLSLIAVSGGLLTLILPETLNTKLPSTIAETASRRQLIDDKSDSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>G8JXZ7</accession>
    <name>G8JXZ7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyridoxine kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">pdxk-1</name>
        <name evidence="9" type="ORF">CELE_F57C9.1</name>
        <name evidence="11" type="ORF">F57C9.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD62442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491464.2">
        <property type="nucleotide sequence ID" value="NM_059063.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JXZ7"/>
    <dbReference type="SMR" id="G8JXZ7"/>
    <dbReference type="PeptideAtlas" id="G8JXZ7"/>
    <dbReference type="GeneID" id="172101"/>
    <dbReference type="AGR" id="WB:WBGene00019008"/>
    <dbReference type="CTD" id="172101"/>
    <dbReference type="WormBase" id="F57C9.1b">
        <property type="protein sequence ID" value="CE44115"/>
        <property type="gene ID" value="WBGene00019008"/>
        <property type="gene designation" value="pdxk-1"/>
    </dbReference>
    <dbReference type="OMA" id="HTQYGQW"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="PhylomeDB" id="G8JXZ7"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019008">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JXZ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="8">
        <location>
            <begin position="30"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD62442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F57C9.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="G8JXZ7"/>
        </source>
    </evidence>
    <sequence length="331" mass="37102" checksum="60DA6CF1D1817D73" modified="2012-01-25" version="1">MSLTTFIRSIRSAVQRDLLKMSSSELIAELERERDRRVLSIQSHVVHGYAGNKCSVFPLQLHGFEVDFINSVQFSNHAGYEHVKGQKLTEKELEELYEGLTLNNINNYTHVLTGYCGNVTFLQKIADVVKDLKKKNGNTTFVCDPVMGDNGRYYTPKELMPVYRDLIIPLADVLTPNAFELGELTGSPIETEEDCLRAVNELHAKGVKTVVVTSGVTGAQTNESLRCYASVKGSHVYRFTFPRLVGQFVGTGDTFTSLLVVWLDELNGDVSEAVKRVLASMQCLIRKTSSYAQLQVDTNSRAMCELRLIQSRKDLLWPPTCDQIQVEKIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY63</accession>
    <name>G8JY63_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">sto-1</name>
        <name evidence="7" type="ORF">CELE_F08C6.4</name>
        <name evidence="9" type="ORF">F08C6.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123124.1">
        <property type="nucleotide sequence ID" value="NM_001129652.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY63"/>
    <dbReference type="SMR" id="G8JY63"/>
    <dbReference type="PeptideAtlas" id="G8JY63"/>
    <dbReference type="GeneID" id="181017"/>
    <dbReference type="AGR" id="WB:WBGene00006063"/>
    <dbReference type="CTD" id="181017"/>
    <dbReference type="WormBase" id="F08C6.4b">
        <property type="protein sequence ID" value="CE41113"/>
        <property type="gene ID" value="WBGene00006063"/>
        <property type="gene designation" value="sto-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_0_1"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006063">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY63">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF129">
        <property type="entry name" value="STOMATIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="62"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD67351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F08C6.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="G8JY63"/>
        </source>
    </evidence>
    <sequence length="325" mass="35898" checksum="A853B1F15A786D02" modified="2012-01-25" version="1">MQPSETVEMQEMAQPSGQQRDVEARVQSAPANHSHDAGCTEMFCIAMSYVLIFLTFPVSVFMCIKIVQEYQRAVVFRLGRLVPDVKGPGIFFIIPCIDTFLNIDLRVASYNVPSQEILSRDSVTVSVDAVVYFKVFDPITSVVGVGNATDSTKLLAQTTLRTILGTHTLSEILSDREKISADMKISLDEATEPWGIKVERVELRDVRLPSQMQRAMAAEAEATRDAGAKIIAAEGELRASAALAEAATIISKSEGAMQLRYLHTLNAISSEKTSTIIFPFPMEILGGISKFQPPHLPQEADSDSKQRKMSYSFVKKQNKDQLEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY65</accession>
    <name>G8JY65_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polycomb protein mes-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mes-3</name>
        <name evidence="2" type="ORF">CELE_F54C1.3</name>
        <name evidence="4" type="ORF">F54C1.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD67545.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001361974.1">
        <property type="nucleotide sequence ID" value="NM_001374884.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY65"/>
    <dbReference type="PeptideAtlas" id="G8JY65"/>
    <dbReference type="GeneID" id="172123"/>
    <dbReference type="AGR" id="WB:WBGene00003221"/>
    <dbReference type="CTD" id="172123"/>
    <dbReference type="WormBase" id="F54C1.3b">
        <property type="protein sequence ID" value="CE53747"/>
        <property type="gene ID" value="WBGene00003221"/>
        <property type="gene designation" value="mes-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877057at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003221">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY65">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD67545.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F54C1.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="G8JY65"/>
        </source>
    </evidence>
    <sequence length="735" mass="84289" checksum="2BAAFD5E6A720E89" modified="2019-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>G8JYA7</accession>
    <name>G8JYA7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nhr-1</name>
        <name evidence="13" type="ORF">CELE_R09G11.2</name>
        <name evidence="15" type="ORF">R09G11.2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD70298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367802.1">
        <property type="nucleotide sequence ID" value="NM_001381184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JYA7"/>
    <dbReference type="SMR" id="G8JYA7"/>
    <dbReference type="PeptideAtlas" id="G8JYA7"/>
    <dbReference type="GeneID" id="181783"/>
    <dbReference type="AGR" id="WB:WBGene00003600"/>
    <dbReference type="CTD" id="181783"/>
    <dbReference type="WormBase" id="R09G11.2d">
        <property type="protein sequence ID" value="CE34355"/>
        <property type="gene ID" value="WBGene00003600"/>
        <property type="gene designation" value="nhr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_892083_0_0_1"/>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003600">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JYA7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Nuclear Hormone Receptor family"/>
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    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NHR-like_dom_sf"/>
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        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
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    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    </dbReference>
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        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="70"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD70298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="R09G11.2d"/>
        </source>
    </evidence>
    <sequence length="312" mass="35291" checksum="98A5D35CACE8F64F" modified="2012-01-25" version="1">MNGTLADQLQSHLANYGQPMVNSQRNEDPSMYMNGSAASVSHTNGSSSMGNDQKFPSYKRMAQRRKVPEGELCAVCSDLATGYHYGVASCNGCKTFFRRTIVSEQTFICQYNGNCDVNKNIRCACRHCRFNKCLLVGMDAKAIQNDRDRIGPTKKIKMSSGSDDEQATTPHRLQDQEIIDQLTQVEGLCQELRRCIIPEVTGVTHALTSPCLLFETTDLKVDVSLTNTIFKELFPASMNDIRMWNIREMRICIEWAKTFDVYQRLNLFDQVGTRNFGCWGIEVFILPKNYAVGKLGKSEVVFSQKILEQLQF</sequence>
</entry>
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    <accession>H2KY56</accession>
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        <submittedName>
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        <name evidence="3 5" type="ORF">C06A5.3</name>
        <name evidence="3" type="ORF">CELE_C06A5.3</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_059331.8"/>
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    <dbReference type="AlphaFoldDB" id="H2KY56"/>
    <dbReference type="SMR" id="H2KY56"/>
    <dbReference type="PeptideAtlas" id="H2KY56"/>
    <dbReference type="GeneID" id="172274"/>
    <dbReference type="AGR" id="WB:WBGene00015501"/>
    <dbReference type="CTD" id="172274"/>
    <dbReference type="WormBase" id="C06A5.3a">
        <property type="protein sequence ID" value="CE37699"/>
        <property type="gene ID" value="WBGene00015501"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359119_0_0_1"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015501">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
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    </dbReference>
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        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="473"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="626"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD61212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C06A5.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KY56"/>
        </source>
    </evidence>
    <sequence length="780" mass="86356" checksum="6ACA937D6FA614F6" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY59</accession>
    <name>H2KY59_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ALG-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">ain-2</name>
        <name evidence="4" type="ORF">B0041.2</name>
        <name evidence="2" type="ORF">CELE_B0041.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD61246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367310.1">
        <property type="nucleotide sequence ID" value="NM_001379889.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY59"/>
    <dbReference type="IntAct" id="H2KY59">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="H2KY59"/>
    <dbReference type="GeneID" id="172076"/>
    <dbReference type="AGR" id="WB:WBGene00015007"/>
    <dbReference type="CTD" id="172076"/>
    <dbReference type="WormBase" id="B0041.2a">
        <property type="protein sequence ID" value="CE27563"/>
        <property type="gene ID" value="WBGene00015007"/>
        <property type="gene designation" value="ain-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5818689at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015007">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY59">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="458"/>
        </location>
    </feature>
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            <begin position="665"/>
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            <dbReference type="EMBL" id="CCD61246.1"/>
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</entry>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
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</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <strain evidence="8 9">Bristol N2</strain>
        </source>
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        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
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        <property type="gene ID" value="WBGene00015038"/>
        <property type="gene designation" value="nstp-6"/>
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        <property type="entry name" value="EmrE-like"/>
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        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD61332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="B0212.4a"/>
        </source>
    </evidence>
    <sequence length="382" mass="42457" checksum="BAA4B88573B4DCA9" modified="2012-03-21" version="1">MTLTVKRQKVGHGIEIDRENEQSSNPIIRVICSVQLISMIAVTAHSTAMPFLVRIANKTHFLPTTSVFMMEVLKLGFCLIITLFKSGSIKKTCHELHKTIWQNRLETMKVAVPAVVYAIQNNLYYIALANVDPTTYSVTLQIRILTTAALSVCLLNKKLSWYQWGAQVMALLGVVIVQLDKTNSHKEAVGNFWIGVSAVVGMCWTSAFAGVYFEKMLKNSSADVWIQNIRLSILTLFFAGITMITTDGEAVFGGRMFEGWSNMVWLVTILNSVGGLCISLVMKYADNVMKTYCQSIAIGLTSLVSICLGERILTVYLVYGVTLVTSSVVVYSLFPVAPPALSDYHKLEQQDDVAELLKSSGVEDEEEEEDEIFGELEHKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY68</accession>
    <name>H2KY68_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CYtochrome P450 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cyp-34a9</name>
        <name evidence="7" type="synonym">cyp-34A9</name>
        <name evidence="9" type="ORF">B0213.15</name>
        <name evidence="7" type="ORF">CELE_B0213.15</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD61363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041071.1">
        <property type="nucleotide sequence ID" value="NM_001047606.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY68"/>
    <dbReference type="SMR" id="H2KY68"/>
    <dbReference type="PeptideAtlas" id="H2KY68"/>
    <dbReference type="GeneID" id="181851"/>
    <dbReference type="KEGG" id="cel:CELE_B0213.15"/>
    <dbReference type="AGR" id="WB:WBGene00015044"/>
    <dbReference type="CTD" id="181851"/>
    <dbReference type="WormBase" id="B0213.15a">
        <property type="protein sequence ID" value="CE30582"/>
        <property type="gene ID" value="WBGene00015044"/>
        <property type="gene designation" value="cyp-34A9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_22_3_1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015044">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY68">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000084">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF122">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD61363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="B0213.15a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="H2KY68"/>
        </source>
    </evidence>
    <sequence length="499" mass="57032" checksum="1F1C202D84CF2D45" modified="2012-03-21" version="1">MILILILSAIVAIFTVNLWRARQKLPKGPTPLPLIGNLHQLIYNAWKNGGIVQGFNEFKKQYGNVFTIWMGPIPSVHIADFDVAHETHVKRANTFGHRFSNGGMDYIREGRGIIASNGEFWQEHRRFALTTLRNFGLGRNIMEDKIMEEYRYRFKDFKNTHFKNGGIQVNASSCFDLLVGSIINQLLVSERFEQDNKEFERLKTSLAKGLEKVSIFEAFMPVWVLKSKLMRWRTKTTFEPFDFIFGLVERGIQKRVSAIKNGTHIPSEEGEDFVDAFLIKMEKDKNEGIQSTFDLETLAVDLYDLWLAGQETTSTTLTWACACLLNYPEVVKEIRKELTEVTGGTRSLSLTDRPKTPYLGATINEIQRIASILNVNIFRLMEEDSIIEGQPISAGAVLTTQLAMLHTDEKTFKNHTEFRPERFLENNNLEKRLIPFGIGKRSCLGESLARAELYLITGNMILDFDFESVGAAPRIQTPTPFALMKRPPSYDIRFIPRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY73</accession>
    <name>H2KY73_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">GLutamate Receptor family (AMPA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">glr-4</name>
        <name evidence="22" type="ORF">C06A8.9</name>
        <name evidence="20" type="ORF">CELE_C06A8.9</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359784.1">
        <property type="nucleotide sequence ID" value="NM_001373747.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY73"/>
    <dbReference type="SMR" id="H2KY73"/>
    <dbReference type="GeneID" id="174258"/>
    <dbReference type="AGR" id="WB:WBGene00001615"/>
    <dbReference type="CTD" id="174258"/>
    <dbReference type="WormBase" id="C06A8.9b">
        <property type="protein sequence ID" value="CE43965"/>
        <property type="gene ID" value="WBGene00001615"/>
        <property type="gene designation" value="glr-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007257_1_1_1"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001615">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY73">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000255">
        <property type="entry name" value="GLutamate Receptor family (AMPA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000192">
        <property type="entry name" value="Glutamate receptor, ionotropic kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003563866" evidence="17">
        <location>
            <begin position="26"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="799"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="18">
        <location>
            <begin position="409"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="19">
        <location>
            <begin position="419"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCD61468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="C06A8.9b"/>
        </source>
    </evidence>
    <sequence length="877" mass="100625" checksum="F1381843F950BC59" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY77</accession>
    <name>H2KY77_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Suppressor of white apricot N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">swp-1</name>
        <name evidence="4" type="ORF">B0336.9</name>
        <name evidence="2" type="ORF">CELE_B0336.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379554.1">
        <property type="nucleotide sequence ID" value="NM_001392108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY77"/>
    <dbReference type="GeneID" id="175795"/>
    <dbReference type="AGR" id="WB:WBGene00006359"/>
    <dbReference type="CTD" id="175795"/>
    <dbReference type="WormBase" id="B0336.9c">
        <property type="protein sequence ID" value="CE31144"/>
        <property type="gene ID" value="WBGene00006359"/>
        <property type="gene designation" value="swp-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190920_0_0_1"/>
    <dbReference type="OrthoDB" id="5836667at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006359">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY77">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of white apricot N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD61527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="B0336.9c"/>
        </source>
    </evidence>
    <sequence length="66" mass="7827" checksum="AEDC7A7FCBB48307" modified="2012-03-21" version="1">MGSWNRRNQVGNNDDQNEYKDLLVFGYASTIFPNDYQSEHIAEERHTVPCLGDPENRVDRYGFFHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY78</accession>
    <name>H2KY78_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Suppressor of white apricot N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">swp-1</name>
        <name evidence="4" type="ORF">B0336.9</name>
        <name evidence="2" type="ORF">CELE_B0336.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379555.1">
        <property type="nucleotide sequence ID" value="NM_001392107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY78"/>
    <dbReference type="GeneID" id="175795"/>
    <dbReference type="AGR" id="WB:WBGene00006359"/>
    <dbReference type="CTD" id="175795"/>
    <dbReference type="WormBase" id="B0336.9e">
        <property type="protein sequence ID" value="CE31146"/>
        <property type="gene ID" value="WBGene00006359"/>
        <property type="gene designation" value="swp-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5836667at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006359">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY78">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of white apricot N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD61529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="B0336.9e"/>
        </source>
    </evidence>
    <sequence length="74" mass="8637" checksum="4928AEF972BC0CD5" modified="2012-03-21" version="1">MGSWNRRNQVGNNDDQNEYKDLLVFGYASTIFPNDYQSEHIAEERHTVPCLGDPENRVDRSIDWLAHRTCQITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY79</accession>
    <name>H2KY79_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hpo-28</name>
        <name evidence="7" type="ORF">B0336.11</name>
        <name evidence="5" type="ORF">CELE_B0336.11</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61532.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379556.1">
        <property type="nucleotide sequence ID" value="NM_001392109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY79"/>
    <dbReference type="SMR" id="H2KY79"/>
    <dbReference type="PeptideAtlas" id="H2KY79"/>
    <dbReference type="GeneID" id="175798"/>
    <dbReference type="KEGG" id="cel:CELE_B0336.11"/>
    <dbReference type="AGR" id="WB:WBGene00015148"/>
    <dbReference type="CTD" id="175798"/>
    <dbReference type="WormBase" id="B0336.11b">
        <property type="protein sequence ID" value="CE52296"/>
        <property type="gene ID" value="WBGene00015148"/>
        <property type="gene designation" value="hpo-28"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_7_1_1"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015148">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY79">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053012">
        <property type="entry name" value="ER-organelle_contact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="4">
        <location>
            <begin position="102"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD61532.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="B0336.11b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KY79"/>
        </source>
    </evidence>
    <sequence length="314" mass="36099" checksum="6F6294AC18811F56" modified="2017-12-20" version="2">MDELAKCLPPPPPPKPSPKLLQQRMHSIDDSTNNNVTEFDFSSFQKRNVKFDEESTTKRAPSLSRRSSRGPKSRKSHIPPSLRPLIENRVNAPSDDWSSNDFVSITPRDELRLEKLDGENDLLDVVLVKNQSSDTPIMFKFKTTSPEKFRVRPSSGIVQPGTTEIIRVYLQYEYRHSWNKEKFLLLTMESSSTDVESFSEQFKSASNKAEFKFKCRLSENLKLDQPEERRSSFLLQQQQLLSKPEGFSLGGFNIYLPIITLILFLFLIFQFSYILQMRSDNALLRETLVSLSSQIKEASVPLQETIVEAVKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY81</accession>
    <name>H2KY81_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">slc-36.5</name>
        <name evidence="9" type="ORF">C44B7.6</name>
        <name evidence="7" type="ORF">CELE_C44B7.6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022027.1">
        <property type="nucleotide sequence ID" value="NM_001026856.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY81"/>
    <dbReference type="SMR" id="H2KY81"/>
    <dbReference type="PeptideAtlas" id="H2KY81"/>
    <dbReference type="GeneID" id="174125"/>
    <dbReference type="AGR" id="WB:WBGene00016628"/>
    <dbReference type="CTD" id="174125"/>
    <dbReference type="WormBase" id="C44B7.6b">
        <property type="protein sequence ID" value="CE02544"/>
        <property type="gene ID" value="WBGene00016628"/>
        <property type="gene designation" value="slc-36.5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_0_1_1"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016628">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY81">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF217">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="21"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD61560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C44B7.6b"/>
        </source>
    </evidence>
    <sequence length="434" mass="47757" checksum="CE8B04A92298803D" modified="2012-03-21" version="1">MTVLFPPSESSVDLEHYKKAISSKFALINLMKGMLGAGCFSVPLAFKQSGYVSGLVIIVVLGFLCALCMIKLVKCAGYLSKVNQSAPLDYGNMAYKATQASYTPIRKLAPVSRALVNSSLCILQLGICCCFYIFVVYHLHELLEFVMNDVPSRATLFPMVLPAFILLVSLSSMRALSLVSLGGNFLMLIALAVIMFQLLTTEHKKLADLPPVTDLMGIVSAAGTILYALEGQAMVLPLENRMKKPEDMKGPFGVLSVGVGMVVVIYSFAGFFGFLTYGNDVQDSITLNLPNDHLGIFVKAVLLFVVYSGFLIQVFPIVAMIWPAIKKKLRTTCGVSTTTKRIVHFAFRYSIVIVVFLLSYAIPRLSDMVPLVGVTAGMLLALVFPSLFHLLIFLPQFECRIGFLFDIFLDFVCIILGMFFVIYGSITHVQHLMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY83</accession>
    <name>H2KY83_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">B0281.5</name>
        <name evidence="2" type="ORF">CELE_B0281.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122573.1">
        <property type="nucleotide sequence ID" value="NM_001129101.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY83"/>
    <dbReference type="SMR" id="H2KY83"/>
    <dbReference type="PeptideAtlas" id="H2KY83"/>
    <dbReference type="GeneID" id="181899"/>
    <dbReference type="KEGG" id="cel:CELE_B0281.5"/>
    <dbReference type="AGR" id="WB:WBGene00015112"/>
    <dbReference type="CTD" id="181899"/>
    <dbReference type="WormBase" id="B0281.5b">
        <property type="protein sequence ID" value="CE41547"/>
        <property type="gene ID" value="WBGene00015112"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086154_0_0_1"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015112">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY83">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF19">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD61639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="B0281.5b"/>
        </source>
    </evidence>
    <sequence length="179" mass="20597" checksum="3575D4F07618E98C" modified="2012-03-21" version="1">MSGNTVKLNVGGTVFETLKSTLTKHDGFFKALIETDVPAEKDDSNCFFIDRSPKHFETVLNYMRSGDVVLPDSKKDMLELKKEAEYYLLSNLAKLCQPPTDNFKTCTPEELMRVVANTDKKVIMINYLTYNGRTESQYPEDGPFPNEKPYWTFLVYNSTRSGRRPFRHTVDLEDCMGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY87</accession>
    <name>H2KY87_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F56C9.6</name>
        <name evidence="2 4" type="ORF">F56C9.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_498610.1">
        <property type="nucleotide sequence ID" value="NM_066209.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY87"/>
    <dbReference type="PeptideAtlas" id="H2KY87"/>
    <dbReference type="GeneID" id="176035"/>
    <dbReference type="AGR" id="WB:WBGene00018950"/>
    <dbReference type="CTD" id="176035"/>
    <dbReference type="WormBase" id="F56C9.6a">
        <property type="protein sequence ID" value="CE01325"/>
        <property type="gene ID" value="WBGene00018950"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5796118at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018950">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY87">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD61831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F56C9.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KY87"/>
        </source>
    </evidence>
    <sequence length="329" mass="37088" checksum="9BD36F9C3FEBDEB5" modified="2012-03-21" version="1">MERVNERREQNNPNGCCLRDEDFSQFNSEAFLRELAADLNEDDTNDLSSSLFATSRIPEEHIRSTGLVERAEHYNKSVDQRTMTDARIAFEEEQLKNGKSPNAGTSGMENLADSGTHVPRRGRGDYFGKLRSFENGVSFPSRPPLTSEHSSSGDSYFNNSHKTTPNYRRFANSNDSSRDNSQMEYKAENDASHTSQSSNRFGFNSQINRTDIHPPAARHTFNPAAAYNGKITPDFRFNYIPNAAVPAPSVVPVIATHPGVAPPSIVPSPIRIGQRYPKRPDNMPKPSSEPKHLNHNYYQIELYGATQEDRIAQRIEKTVRQTEAPVRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY88</accession>
    <name>H2KY88_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BCAS3 WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F56C9.10</name>
        <name evidence="3 5" type="ORF">F56C9.10</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741222.1">
        <property type="nucleotide sequence ID" value="NM_171190.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY88"/>
    <dbReference type="SMR" id="H2KY88"/>
    <dbReference type="PeptideAtlas" id="H2KY88"/>
    <dbReference type="GeneID" id="176040"/>
    <dbReference type="AGR" id="WB:WBGene00018953"/>
    <dbReference type="CTD" id="176040"/>
    <dbReference type="WormBase" id="F56C9.10a">
        <property type="protein sequence ID" value="CE01320"/>
        <property type="gene ID" value="WBGene00018953"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_294275_0_0_1"/>
    <dbReference type="OrthoDB" id="25778at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018953">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY88">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001585">
        <property type="entry name" value="Protein CBG00600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048382">
        <property type="entry name" value="BCAS3_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21034">
        <property type="entry name" value="BCAS3_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCAS3 WD40" evidence="2">
        <location>
            <begin position="242"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD61833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F56C9.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KY88"/>
        </source>
    </evidence>
    <sequence length="1028" mass="111747" checksum="B1E994ABFA4D4BFD" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY92</accession>
    <name>H2KY92_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">dagl-2</name>
        <name evidence="18" type="ORF">CELE_F42G9.6</name>
        <name evidence="20" type="ORF">F42G9.6</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370332.1">
        <property type="nucleotide sequence ID" value="NM_001384013.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY92"/>
    <dbReference type="SMR" id="H2KY92"/>
    <dbReference type="GeneID" id="3565075"/>
    <dbReference type="AGR" id="WB:WBGene00018364"/>
    <dbReference type="CTD" id="3565075"/>
    <dbReference type="WormBase" id="F42G9.6a">
        <property type="protein sequence ID" value="CE30791"/>
        <property type="gene ID" value="WBGene00018364"/>
        <property type="gene designation" value="dagl-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008300_2_1_1"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018364">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY92">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000374">
        <property type="entry name" value="DiAcylGlycerol Lipase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF2">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="17">
        <location>
            <begin position="346"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCD61888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="F42G9.6a"/>
        </source>
    </evidence>
    <sequence length="657" mass="73752" checksum="56F8595EEBE514AC" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY94</accession>
    <name>H2KY94_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ptl-1</name>
        <name evidence="8" type="ORF">CELE_F42G9.9</name>
        <name evidence="10" type="ORF">F42G9.9</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379577.1">
        <property type="nucleotide sequence ID" value="NM_001393262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY94"/>
    <dbReference type="PeptideAtlas" id="H2KY94"/>
    <dbReference type="GeneID" id="175230"/>
    <dbReference type="AGR" id="WB:WBGene00004212"/>
    <dbReference type="CTD" id="175230"/>
    <dbReference type="WormBase" id="F42G9.9d">
        <property type="protein sequence ID" value="CE30793"/>
        <property type="gene ID" value="WBGene00004212"/>
        <property type="gene designation" value="ptl-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048796_0_0_1"/>
    <dbReference type="OrthoDB" id="9378527at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004212">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY94">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF18">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD61895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F42G9.9d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="H2KY94"/>
        </source>
    </evidence>
    <sequence length="252" mass="27265" checksum="7D2849554C0E7F7F" modified="2012-03-21" version="1">MEDIAPRELESLNFSETSGTSDQQADRIMQNNENERVEEKKQMSPTPSQPQHKTPQRSGIRPPTAILRQPKPIPASLPRPATATPSSQRAISTPRQTASTAPSPRPISKMSRERSDVQKSTSTRSIDNVGRMTPKVNAKFVNVKSKVGSVTNHKAGGGNVEIFSEKRLYNAQSKVGSLKNATHVAGGGNVQIENRKLDFSAASPKVGSKTNYQPAKSDVKIVSEKLTWQAKSKVGSMDNAAHKPAGGNVQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY95</accession>
    <name>H2KY95_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty Acid/Retinol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">far-7</name>
        <name evidence="7" type="ORF">CELE_K01A2.2</name>
        <name evidence="9" type="ORF">K01A2.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty-acid and retinol-binding protein (FARBP) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61951.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_871991.2">
        <property type="nucleotide sequence ID" value="NM_182191.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY95"/>
    <dbReference type="SMR" id="H2KY95"/>
    <dbReference type="PeptideAtlas" id="H2KY95"/>
    <dbReference type="GeneID" id="173421"/>
    <dbReference type="AGR" id="WB:WBGene00001391"/>
    <dbReference type="CTD" id="173421"/>
    <dbReference type="WormBase" id="K01A2.2b">
        <property type="protein sequence ID" value="CE50695"/>
        <property type="gene ID" value="WBGene00001391"/>
        <property type="gene designation" value="far-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2591943_0_0_1"/>
    <dbReference type="OrthoDB" id="5856727at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001391">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY95">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008632">
        <property type="entry name" value="Gp-FAR-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05823">
        <property type="entry name" value="Gp-FAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD61951.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="K01A2.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="H2KY95"/>
        </source>
    </evidence>
    <sequence length="90" mass="10001" checksum="6401D2C8A1C296CA" modified="2015-11-11" version="2">MIDEVSKKHPELGKRLATVLEGNKKRLDGLSPAAVEYAKKLIHMVTTTLCSLTVGKPIDDADAKRLHQEFQSLSSEDQAALRKNNPDIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY96</accession>
    <name>H2KY96_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">cbn-1</name>
        <name evidence="11" type="ORF">CELE_K01A2.11</name>
        <name evidence="13" type="ORF">K01A2.11</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_493711.2">
        <property type="nucleotide sequence ID" value="NM_061310.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY96"/>
    <dbReference type="SMR" id="H2KY96"/>
    <dbReference type="PeptideAtlas" id="H2KY96"/>
    <dbReference type="GeneID" id="173423"/>
    <dbReference type="AGR" id="WB:WBGene00019285"/>
    <dbReference type="CTD" id="173423"/>
    <dbReference type="WormBase" id="K01A2.11a">
        <property type="protein sequence ID" value="CE35985"/>
        <property type="gene ID" value="WBGene00019285"/>
        <property type="gene designation" value="cbn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019285">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KY96">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF98">
        <property type="entry name" value="45 KDA CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564192" evidence="9">
        <location>
            <begin position="19"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD61962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="K01A2.11a"/>
        </source>
    </evidence>
    <sequence length="585" mass="64910" checksum="F406A3AAB85F0A63" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H2KY98</accession>
    <name>H2KY98_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_Y25C1A.7</name>
        <name evidence="8 10" type="ORF">Y25C1A.7</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_494439.1">
        <property type="nucleotide sequence ID" value="NM_062038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KY98"/>
    <dbReference type="PeptideAtlas" id="H2KY98"/>
    <dbReference type="GeneID" id="173654"/>
    <dbReference type="AGR" id="WB:WBGene00021294"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016192">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Yip1_dom"/>
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    <dbReference type="PANTHER" id="PTHR12822">
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="120"/>
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        <location>
            <begin position="110"/>
            <end position="266"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04893"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD61984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y25C1A.7b"/>
        </source>
    </evidence>
    <sequence length="287" mass="31822" checksum="6D31956ED2CE5C63" modified="2012-03-21" version="1">MAQPAPPSQKWEDVNLDFDNVNSTNEQSGAFGGNIGDRNILVGGSVGATSSAAPSGGVFDDSQSTTSTRKGNFFSFEYYQQFFDVETDQVIKRLLNSVIPTHRNYIQDFLQPIPDLWGPFWVSVTLVFAIGIFGNLAQFIENDGAKGTYGSDFRMVTSASTLIFLYVVIVPLLLYGLLWNRRSELLHPYVDLVCLYGYSLAIFIPVSVLWIVDIGWFRWALIFASVGLSGTVLARAIWPAVQNDNNKMIAFGTVISVVVLHFLLAFTFKVYFFDSMHIVVVASPSPI</sequence>
</entry>
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    <accession>O45527</accession>
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        <name evidence="2" type="ORF">CELE_F47H4.2</name>
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        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB07204.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T22369"/>
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        <property type="nucleotide sequence ID" value="NM_074995.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O45527"/>
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    <dbReference type="UCSC" id="F47H4.2">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="WormBase" id="F47H4.2a">
        <property type="protein sequence ID" value="CE37016"/>
        <property type="gene ID" value="WBGene00009835"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="O45527"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009835">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002900">
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        <property type="entry name" value="DUF38 DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23014">
        <property type="entry name" value="F-BOX A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01827">
        <property type="entry name" value="FTH"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="131"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF38" evidence="1">
        <location>
            <begin position="485"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB07204.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="F47H4.2a"/>
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    </evidence>
    <sequence length="687" mass="80625" checksum="8271E95EF2EB4281" modified="2004-09-13" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>O45530</accession>
    <name>O45530_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
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        <name evidence="4 6" type="primary">clec-24</name>
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    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB04415.4"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001269801.2"/>
    </dbReference>
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    <dbReference type="UCSC" id="F49A5.4">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
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    <dbReference type="WormBase" id="F49A5.4a">
        <property type="protein sequence ID" value="CE48375"/>
        <property type="gene ID" value="WBGene00009856"/>
        <property type="gene designation" value="clec-24"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
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        <property type="entry name" value="Snaclec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22991:SF43">
        <property type="entry name" value="C-TYPE LECTIN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN CBG13490"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="124"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="259"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB04415.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F49A5.4a"/>
        </source>
    </evidence>
    <sequence length="373" mass="42109" checksum="F09D6F8B09F0A35F" modified="2013-06-26" version="4">MFNKFLKRFTAHFSISTICVICITLFTGVTPHLNELIFLSILPIPPVIKMMLGKLNRFLQLHWMVILLGIIFEILFTIGVVRLTYFLTKQASVESNTSPTPRLLSTSSTLASGNRTCTDGFTHINNKCWKLVTGPKSRADADKTCYDLGGSTLFSIRNDQENQALMEFVKDQKVENLWAGLICDRHGPAWCTWDLQSGTTAVYNNFADGWPSNEDKICNYFMTNGTQAGKWASASCTETMSFVCELPATIYDNTCEYNYDNYCYTPYFELKLSSEAQTFCASSGSNLVSIHSANENRFVYNIIPPGTETSIGGVAYSDDSLLWYDGTPPLFTNMIQLENGNCLFLYNDYVHWFGNNCLTTKCHFVCKRRISEK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>O45541</accession>
    <name>O45541_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleolar protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F49E2.5</name>
        <name evidence="2 4" type="ORF">F49E2.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAA86424.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T22454">
        <property type="entry name" value="T22454"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O45541"/>
    <dbReference type="SMR" id="O45541"/>
    <dbReference type="PeptideAtlas" id="O45541"/>
    <dbReference type="UCSC" id="F49E2.5j.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009888"/>
    <dbReference type="WormBase" id="F49E2.5c">
        <property type="protein sequence ID" value="CE31531"/>
        <property type="gene ID" value="WBGene00009888"/>
    </dbReference>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009888">
        <property type="expression patterns" value="Expressed in larva and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O45541">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006836">
        <property type="entry name" value="DUF612"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31765">
        <property type="entry name" value="PROTEIN CBG12783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31765:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04747">
        <property type="entry name" value="DUF612"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA86427.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F49E2.5d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="O45544"/>
        </source>
    </evidence>
    <sequence length="889" mass="98113" checksum="72C6605EE929139D" modified="2002-10-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>O45562</accession>
    <name>O45562_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small, acid-soluble spore protein gamma-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F54B8.4</name>
        <name evidence="2 4" type="ORF">F54B8.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB07626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T22621">
        <property type="entry name" value="T22621"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256685.1">
        <property type="nucleotide sequence ID" value="NM_001269756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O45562"/>
    <dbReference type="GeneID" id="186201"/>
    <dbReference type="UCSC" id="F54B8.4">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010019"/>
    <dbReference type="CTD" id="186201"/>
    <dbReference type="WormBase" id="F54B8.4a">
        <property type="protein sequence ID" value="CE16106"/>
        <property type="gene ID" value="WBGene00010019"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2225539_0_0_1"/>
    <dbReference type="OrthoDB" id="5973225at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010019">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O45562">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007007"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024130">
        <property type="entry name" value="DAP1/DAPL1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15228">
        <property type="entry name" value="DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB07626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F54B8.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="O45562"/>
        </source>
    </evidence>
    <sequence length="96" mass="10496" checksum="6EF276054DE9E094" modified="1998-06-01" version="1">MSKEDNNAVVGHQPATKVGGRRIADHGNQRAQNSTNSSDAVREAMDFDLPAKMEKAYPTAAVKQVHEKPTPAIQPAHYNRATGNGQVRNIPQKQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>O45574</accession>
    <name>O45574_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F56A8.3</name>
        <name evidence="3 5" type="ORF">F56A8.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAB05743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T22764">
        <property type="entry name" value="T22764"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_499731.1">
        <property type="nucleotide sequence ID" value="NM_067330.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O45574"/>
    <dbReference type="SMR" id="O45574"/>
    <dbReference type="PeptideAtlas" id="O45574"/>
    <dbReference type="GeneID" id="176740"/>
    <dbReference type="UCSC" id="F56A8.3a.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010139"/>
    <dbReference type="CTD" id="176740"/>
    <dbReference type="WormBase" id="F56A8.3b">
        <property type="protein sequence ID" value="CE16123"/>
        <property type="gene ID" value="WBGene00010139"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095812_0_0_1"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010139">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O45574">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB05743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F56A8.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="O45574"/>
        </source>
    </evidence>
    <sequence length="254" mass="28124" checksum="B44ACCE8554C2C68" modified="1998-06-01" version="1">MAKKDAKQQRETVNAASHKNNHSQQPKSQKKEPHPKKNEQKKTEQPRGFFRKLFGFVWSCVFYLTIVVATSSTVAIALDCKGLGSPIPGTAPLCKDLTLMATGNKPSAAFVKNTRAAYGSVLQGYHNQVKPHVAPVQAAVSKKWKQFAKSDVGGKVEKIAMNIHAWIVDKWVKIQRFVQQTWNNVAAWWKKNGQKQFGPALEGFVLGVKMVFQVVADALRSVGALLVHFFARAKTFFVAFADGGFNAAMNTLNH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-03-27" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>O76720-2</accession>
    <name>SLFL4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Schlafen-like protein 4</fullName>
            <shortName evidence="1">SLFN-like 4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PUCH complex member slfl-4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">slfl-4</name>
        <name evidence="4" type="ORF">F36H12.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Nature" volume="622" first="402" last="409">
            <title>piRNA processing by a trimeric Schlafen-domain nuclease.</title>
            <authorList>
                <person name="Podvalnaya N."/>
                <person name="Bronkhorst A.W."/>
                <person name="Lichtenberger R."/>
                <person name="Hellmann S."/>
                <person name="Nischwitz E."/>
                <person name="Falk T."/>
                <person name="Karaulanov E."/>
                <person name="Butter F."/>
                <person name="Falk S."/>
                <person name="Ketting R.F."/>
            </authorList>
            <dbReference type="PubMed" id="37758951"/>
            <dbReference type="DOI" id="10.1038/s41586-023-06588-2"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN THE PUCH COMPLEX</scope>
        <scope>INTERACTION WITH TOFU-2</scope>
        <scope>INTERACTION WITH PETISCO COMPLEX</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O76720-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_062237"/>
        </isoform>
        <isoform>
            <id>O76720-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001293742.1">
        <property type="nucleotide sequence ID" value="NM_001306813.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F36H12.2b">
        <property type="protein sequence ID" value="CE49225"/>
        <property type="gene ID" value="WBGene00018118"/>
        <property type="gene designation" value="slfl-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="37758951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F36H12.2a"/>
        </source>
    </evidence>
    <sequence length="384" mass="43861" checksum="DE215E9E5DA0A09E" modified="2003-10-01" version="2">MDSVDFSPTMQSRFSTGFMSFEDNPEDVRTIEMIDKIVFEEDEEYDLTQDSFRYGRVTTGASYNLVTGKIPETVLEQVKAKDDENDDVEFEMDHLEDKEAVQKTKTFDELYESQMPKYFEYQSNFSEVNGIWTLLFDQNHYENMSTFELQAAICAALNSKHYMMICVGIDAFNAVTGVEMSAKDRVVFRMALTRAVAGEFQPPLVKVAPKQLTGVSPMKRDISEVTSSIDVLFIPVIGVTDEVENNRFLIVVRVKEISDKVYQISSGRIYNELEGRVVEMSDMNEAFHKLIVEQSISDIQTRRGSMFMLEPEPFLEDSPVIFTGSKEILRENHEIPNILKENSTERSLSQSLLNLLDIQNIGWIFFGTALSCCIYNNAIKPLVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>O76840-2</accession>
    <name>PPN1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Papilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Abnormal cell migration protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mig-6</name>
        <name type="synonym">ppn-1</name>
        <name type="ORF">C37C3.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Development" volume="127" first="5475" last="5485">
            <title>Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases.</title>
            <authorList>
                <person name="Kramerova I.A."/>
                <person name="Kawaguchi N."/>
                <person name="Fessler L.I."/>
                <person name="Nelson R.E."/>
                <person name="Chen Y."/>
                <person name="Kramerov A.A."/>
                <person name="Kusche-Gullberg M."/>
                <person name="Kramer J.M."/>
                <person name="Ackley B.D."/>
                <person name="Sieron A.L."/>
                <person name="Prockop D.J."/>
                <person name="Fessler J.H."/>
            </authorList>
            <dbReference type="PubMed" id="11076767"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="667" last="672">
            <title>Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Saito H."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Hirabayashi J."/>
                <person name="Kasai K."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="12754521"/>
            <dbReference type="DOI" id="10.1038/nbt829"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-386; ASN-445; ASN-541; ASN-568; ASN-638; ASN-857; ASN-933 AND ASN-1090</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Glycobiology" volume="15" first="952" last="964">
            <title>Identification of the hydrophobic glycoproteins of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Fan X."/>
                <person name="She Y.-M."/>
                <person name="Bagshaw R.D."/>
                <person name="Callahan J.W."/>
                <person name="Schachter H."/>
                <person name="Mahuran D.J."/>
            </authorList>
            <dbReference type="PubMed" id="15888633"/>
            <dbReference type="DOI" id="10.1093/glycob/cwi075"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-445; ASN-857 AND ASN-1090</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-268; ASN-386; ASN-445; ASN-541; ASN-568; ASN-638; ASN-857; ASN-933; ASN-1090 AND ASN-1992</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Development" volume="136" first="1433" last="1442">
            <title>C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IV.</title>
            <authorList>
                <person name="Kawano T."/>
                <person name="Zheng H."/>
                <person name="Merz D.C."/>
                <person name="Kohara Y."/>
                <person name="Tamai K.K."/>
                <person name="Nishiwaki K."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="19297413"/>
            <dbReference type="DOI" id="10.1242/dev.028472"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2010" name="Genetics" volume="186" first="969" last="982">
            <title>Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx model.</title>
            <authorList>
                <person name="Jafari G."/>
                <person name="Burghoorn J."/>
                <person name="Kawano T."/>
                <person name="Mathew M."/>
                <person name="Moerck C."/>
                <person name="Axaeng C."/>
                <person name="Ailion M."/>
                <person name="Thomas J.H."/>
                <person name="Culotti J.G."/>
                <person name="Swoboda P."/>
                <person name="Pilon M."/>
            </authorList>
            <dbReference type="PubMed" id="20805556"/>
            <dbReference type="DOI" id="10.1534/genetics.110.120519"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF TYR-650; CYS-848; 878-GLY-CYS-879; GLY-965 AND CYS-973</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in embryogenesis, the second phase of distal cell tip migration and is required for distribution of the metalloproteinase, mig-17, during organogenesis.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O76840-1</id>
            <name>b</name>
            <name>mig-6L</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O76840-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_020309 VSP_020308 VSP_020307"/>
        </isoform>
        <isoform>
            <id>O76840-2</id>
            <name>a</name>
            <name>mig-6S</name>
            <sequence type="described" ref="VSP_020309 VSP_020308"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001370555.1">
        <property type="nucleotide sequence ID" value="NM_001383344.2"/>
    </dbReference>
    <dbReference type="WormBase" id="C37C3.6a">
        <property type="protein sequence ID" value="CE17535"/>
        <property type="gene ID" value="WBGene00003242"/>
        <property type="gene designation" value="mig-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="19297413"/>
        </source>
    </evidence>
    <sequence length="1558" mass="169604" checksum="38FCAA2CA6B80D6B" modified="1998-11-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>O76840-3</accession>
    <name>PPN1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Papilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Abnormal cell migration protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mig-6</name>
        <name type="synonym">ppn-1</name>
        <name type="ORF">C37C3.6</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Development" volume="127" first="5475" last="5485">
            <title>Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases.</title>
            <authorList>
                <person name="Kramerova I.A."/>
                <person name="Kawaguchi N."/>
                <person name="Fessler L.I."/>
                <person name="Nelson R.E."/>
                <person name="Chen Y."/>
                <person name="Kramerov A.A."/>
                <person name="Kusche-Gullberg M."/>
                <person name="Kramer J.M."/>
                <person name="Ackley B.D."/>
                <person name="Sieron A.L."/>
                <person name="Prockop D.J."/>
                <person name="Fessler J.H."/>
            </authorList>
            <dbReference type="PubMed" id="11076767"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="667" last="672">
            <title>Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Saito H."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Hirabayashi J."/>
                <person name="Kasai K."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="12754521"/>
            <dbReference type="DOI" id="10.1038/nbt829"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-386; ASN-445; ASN-541; ASN-568; ASN-638; ASN-857; ASN-933 AND ASN-1090</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Glycobiology" volume="15" first="952" last="964">
            <title>Identification of the hydrophobic glycoproteins of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Fan X."/>
                <person name="She Y.-M."/>
                <person name="Bagshaw R.D."/>
                <person name="Callahan J.W."/>
                <person name="Schachter H."/>
                <person name="Mahuran D.J."/>
            </authorList>
            <dbReference type="PubMed" id="15888633"/>
            <dbReference type="DOI" id="10.1093/glycob/cwi075"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-445; ASN-857 AND ASN-1090</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-268; ASN-386; ASN-445; ASN-541; ASN-568; ASN-638; ASN-857; ASN-933; ASN-1090 AND ASN-1992</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Development" volume="136" first="1433" last="1442">
            <title>C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IV.</title>
            <authorList>
                <person name="Kawano T."/>
                <person name="Zheng H."/>
                <person name="Merz D.C."/>
                <person name="Kohara Y."/>
                <person name="Tamai K.K."/>
                <person name="Nishiwaki K."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="19297413"/>
            <dbReference type="DOI" id="10.1242/dev.028472"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2010" name="Genetics" volume="186" first="969" last="982">
            <title>Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx model.</title>
            <authorList>
                <person name="Jafari G."/>
                <person name="Burghoorn J."/>
                <person name="Kawano T."/>
                <person name="Mathew M."/>
                <person name="Moerck C."/>
                <person name="Axaeng C."/>
                <person name="Ailion M."/>
                <person name="Thomas J.H."/>
                <person name="Culotti J.G."/>
                <person name="Swoboda P."/>
                <person name="Pilon M."/>
            </authorList>
            <dbReference type="PubMed" id="20805556"/>
            <dbReference type="DOI" id="10.1534/genetics.110.120519"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF TYR-650; CYS-848; 878-GLY-CYS-879; GLY-965 AND CYS-973</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O76840-1</id>
            <name>b</name>
            <name>mig-6L</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O76840-2</id>
            <name>a</name>
            <name>mig-6S</name>
            <sequence type="described" ref="VSP_020308 VSP_020309"/>
        </isoform>
        <isoform>
            <id>O76840-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_020307 VSP_020309 VSP_020308"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741569.1">
        <property type="nucleotide sequence ID" value="NM_171931.7"/>
    </dbReference>
    <dbReference type="WormBase" id="C37C3.6c">
        <property type="protein sequence ID" value="CE30735"/>
        <property type="gene ID" value="WBGene00003242"/>
        <property type="gene designation" value="mig-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="1487" mass="162109" checksum="3DB432B96B90FD4E" modified="1998-11-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-02-01" modified="2026-01-28" version="195" xmlns="https://uniprot.org/uniprot">
    <accession>P20792-2</accession>
    <name>DAF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Cell surface receptor daf-1</fullName>
            <ecNumber>2.7.11.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Abnormal dauer formation protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">daf-1</name>
        <name type="ORF">F29C4.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Cell" volume="61" first="635" last="645">
            <title>daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase.</title>
            <authorList>
                <person name="Georgi L.L."/>
                <person name="Albert P.S."/>
                <person name="Riddle D.L."/>
            </authorList>
            <dbReference type="PubMed" id="2160853"/>
            <dbReference type="DOI" id="10.1016/0092-8674(90)90475-T"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Development" volume="127" first="3337" last="3347">
            <title>A Caenorhabditis elegans type I TGF beta receptor can function in the absence of type II kinase to promote larval development.</title>
            <authorList>
                <person name="Gunther C.V."/>
                <person name="Georgi L.L."/>
                <person name="Riddle D.L."/>
            </authorList>
            <dbReference type="PubMed" id="10887089"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF GLY-70; CYS-90; GLU-105 AND GLY-110</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2008" name="Cell Metab." volume="7" first="249" last="257">
            <title>Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety.</title>
            <authorList>
                <person name="You Y.J."/>
                <person name="Kim J."/>
                <person name="Raizen D.M."/>
                <person name="Avery L."/>
            </authorList>
            <dbReference type="PubMed" id="18316030"/>
            <dbReference type="DOI" id="10.1016/j.cmet.2008.01.005"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="8038" last="8043">
            <title>Acute carbon dioxide avoidance in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hallem E.A."/>
                <person name="Sternberg P.W."/>
            </authorList>
            <dbReference type="PubMed" id="18524955"/>
            <dbReference type="DOI" id="10.1073/pnas.0707469105"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
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            <title>The homeodomain protein hmbx-1 maintains asymmetric gene expression in adult C. elegans olfactory neurons.</title>
            <authorList>
                <person name="Lesch B.J."/>
                <person name="Bargmann C.I."/>
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            <dbReference type="PubMed" id="20713521"/>
            <dbReference type="DOI" id="10.1101/gad.1932610"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-400</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P20792-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P20792-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_007948"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.30"/>
    <dbReference type="RefSeq" id="NP_001023160.1">
        <property type="nucleotide sequence ID" value="NM_001027989.6"/>
    </dbReference>
    <dbReference type="WormBase" id="F29C4.1b">
        <property type="protein sequence ID" value="CE31492"/>
        <property type="gene ID" value="WBGene00000897"/>
        <property type="gene designation" value="daf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="668" mass="74907" checksum="EED85A548CE780B2" modified="1991-02-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>P34422-2</accession>
    <name>DPF6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Dipeptidyl peptidase family member 6</fullName>
            <ecNumber>3.4.14.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dpf-6</name>
        <name type="ORF">F44B9.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
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            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
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                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34422-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34422-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_007096 VSP_007095"/>
        </isoform>
        <isoform>
            <id>P34422-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_007098 VSP_007097"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.14.-"/>
    <dbReference type="RefSeq" id="NP_741242.1">
        <property type="nucleotide sequence ID" value="NM_171205.6"/>
    </dbReference>
    <dbReference type="WormBase" id="F44B9.1b">
        <property type="protein sequence ID" value="CE30990"/>
        <property type="gene ID" value="WBGene00001059"/>
        <property type="gene designation" value="dpf-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="511" mass="57424" checksum="73091F1CFB691558" modified="2003-03-28" version="2">MYNFRPITFDKSNNFMYWIMGDGSDLGNLVVFPFEDPQQKEILYTAQRAQIGNVLIHPTDKTLLAVTEVYHKPELFVANETFMEDLQYLVNMKPSGSMNIVSMSIDMSTWLVTYSSSDEPYDIYLYRRWNKKAELFMSTRPELKKYTLNKQIGFDFRARDEMTIQAYLSLPPQAPLLKSSQVPDGDRPYANLGMIPAVPQKMIVLVHGGPKARDHYGFSPMNAWLTNRGYSVLQVNFRGSTGFGKRLTNAGNGEWGRKMHFDILDAVEFAVSKGIANRSEVAVMGGSYGGYETLVALTFTPQTFACGVDIVGPSNLISLVQAIPPYWLGFRKDLIKMVGADISDEEGRQSLQSRSPLFFADRVTKPIMIIQGANDPRVKQAESDQFVAALEKKHIPVTYLLYPDEGHGVRKPQNSMEQHGHIETFLQQCLGGETQPFQPGQYNSSAIIKKIGIEGAAIARQNLQIAQNQFAQQLPRGPVAPSIFYRPPVRAQRVMLAPNQNVMNRIFPVQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>P34422-3</accession>
    <name>DPF6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Dipeptidyl peptidase family member 6</fullName>
            <ecNumber>3.4.14.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dpf-6</name>
        <name type="ORF">F44B9.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34422-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34422-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_007095 VSP_007096"/>
        </isoform>
        <isoform>
            <id>P34422-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_007098 VSP_007097"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.14.-"/>
    <dbReference type="RefSeq" id="NP_001370390.1">
        <property type="nucleotide sequence ID" value="NM_001382930.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F44B9.1c">
        <property type="protein sequence ID" value="CE30991"/>
        <property type="gene ID" value="WBGene00001059"/>
        <property type="gene designation" value="dpf-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="573" mass="64834" checksum="962A292A11D98EF9" modified="2003-03-28" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-12-11" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>P91277-2</accession>
    <name>HRPK1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform b of Heterogeneous nuclear ribonucleoprotein K homolog</fullName>
            <shortName evidence="1">hnRNP K</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrpk-1</name>
        <name evidence="3" type="ORF">F26B1.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2005" name="Genetics" volume="169" first="1451" last="1460">
            <title>Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Holway A.H."/>
                <person name="Hung C."/>
                <person name="Michael W.M."/>
            </authorList>
            <dbReference type="PubMed" id="15654100"/>
            <dbReference type="DOI" id="10.1534/genetics.104.036137"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2019" name="PLoS Genet." volume="15" first="E1008067" last="E1008067">
            <title>HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development.</title>
            <authorList>
                <person name="Li L."/>
                <person name="Veksler-Lublinsky I."/>
                <person name="Zinovyeva A."/>
            </authorList>
            <dbReference type="PubMed" id="31584932"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1008067"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ALG-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P91277-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060458 VSP_060454 VSP_060455"/>
        </isoform>
        <isoform>
            <id>P91277-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060454 VSP_060456 VSP_060457"/>
        </isoform>
        <isoform>
            <id>P91277-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060459"/>
        </isoform>
        <isoform>
            <id>P91277-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060454"/>
        </isoform>
        <isoform>
            <id>P91277-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379657.1">
        <property type="nucleotide sequence ID" value="NM_001392432.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F26B1.2b">
        <property type="protein sequence ID" value="CE33057"/>
        <property type="gene ID" value="WBGene00017816"/>
        <property type="gene designation" value="hrpk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F26B1.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F26B1.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F26B1.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F26B1.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F26B1.2e"/>
        </source>
    </evidence>
    <sequence length="67" mass="7636" checksum="B3D3EA42FF5C800E" modified="1997-05-01" version="1">MKREHDNDDGDRTGRHKRPKTDGFTEAIQQGKFEVRLLVSSKSAGAIIGKGGENIKRLRAERLHRYC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-12-11" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>P91277-3</accession>
    <name>HRPK1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform c of Heterogeneous nuclear ribonucleoprotein K homolog</fullName>
            <shortName evidence="1">hnRNP K</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrpk-1</name>
        <name evidence="3" type="ORF">F26B1.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2005" name="Genetics" volume="169" first="1451" last="1460">
            <title>Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Holway A.H."/>
                <person name="Hung C."/>
                <person name="Michael W.M."/>
            </authorList>
            <dbReference type="PubMed" id="15654100"/>
            <dbReference type="DOI" id="10.1534/genetics.104.036137"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2019" name="PLoS Genet." volume="15" first="E1008067" last="E1008067">
            <title>HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development.</title>
            <authorList>
                <person name="Li L."/>
                <person name="Veksler-Lublinsky I."/>
                <person name="Zinovyeva A."/>
            </authorList>
            <dbReference type="PubMed" id="31584932"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1008067"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ALG-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P91277-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060455 VSP_060454 VSP_060458"/>
        </isoform>
        <isoform>
            <id>P91277-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P91277-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060456 VSP_060457 VSP_060454"/>
        </isoform>
        <isoform>
            <id>P91277-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060454"/>
        </isoform>
        <isoform>
            <id>P91277-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060459"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379658.1">
        <property type="nucleotide sequence ID" value="NM_001392431.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F26B1.2c">
        <property type="protein sequence ID" value="CE33058"/>
        <property type="gene ID" value="WBGene00017816"/>
        <property type="gene designation" value="hrpk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F26B1.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F26B1.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F26B1.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F26B1.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F26B1.2e"/>
        </source>
    </evidence>
    <sequence length="380" mass="40525" checksum="A2490B4E013AF1F4" modified="1997-05-01" version="1">MKREHDNDDGDRTGRHKRPKTDGFTEAIQQGKFEVRLLVSSKSAGAIIGKGGENIKRLRAEFNAHVQVPDSNTPERVCTVTADEKTVLNILKDVLPRLEDNFSERDPCEVRMLVHQSHAGALIGRNGSKIKELREKCSARLKIFTGCAPGSTDRVLITSGEQKNVLGIIEEVMKELKEIPIKGSATPYLPAFNYDPSNISDYGGFPGNMPAGGPPNNRGPAPQRGGQGPPGGPRSYGGAITQGGGQRSFEAGDFQQFRGGPGPVPGYAMSAPGYPPQQGQFGAPNNAGYGYGPGGGGPVTTAQVTIPSDLGGTIIGRGGERIARIRQESGAQITLEQSNGQPERIITIKGTEQQIHSAQYLLQQCVRNSTQGRERFGGSV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-12-11" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>P91277-4</accession>
    <name>HRPK1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform d of Heterogeneous nuclear ribonucleoprotein K homolog</fullName>
            <shortName evidence="1">hnRNP K</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrpk-1</name>
        <name evidence="3" type="ORF">F26B1.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2005" name="Genetics" volume="169" first="1451" last="1460">
            <title>Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Holway A.H."/>
                <person name="Hung C."/>
                <person name="Michael W.M."/>
            </authorList>
            <dbReference type="PubMed" id="15654100"/>
            <dbReference type="DOI" id="10.1534/genetics.104.036137"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2019" name="PLoS Genet." volume="15" first="E1008067" last="E1008067">
            <title>HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development.</title>
            <authorList>
                <person name="Li L."/>
                <person name="Veksler-Lublinsky I."/>
                <person name="Zinovyeva A."/>
            </authorList>
            <dbReference type="PubMed" id="31584932"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1008067"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ALG-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P91277-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060454 VSP_060457 VSP_060456"/>
        </isoform>
        <isoform>
            <id>P91277-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060455 VSP_060458 VSP_060454"/>
        </isoform>
        <isoform>
            <id>P91277-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060459"/>
        </isoform>
        <isoform>
            <id>P91277-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060454"/>
        </isoform>
        <isoform>
            <id>P91277-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379659.1">
        <property type="nucleotide sequence ID" value="NM_001392433.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F26B1.2d">
        <property type="protein sequence ID" value="CE33059"/>
        <property type="gene ID" value="WBGene00017816"/>
        <property type="gene designation" value="hrpk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F26B1.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F26B1.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F26B1.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F26B1.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F26B1.2e"/>
        </source>
    </evidence>
    <sequence length="71" mass="7888" checksum="D7843B2FDD20CFEA" modified="1997-05-01" version="1">MKREHDNDDGDRTGRHKRPKTDGFTEAIQQGKFEVRLLVSSKSAGAIIGKGGENIKRLRAEVSFTGILLCF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-12-11" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>P91277-5</accession>
    <name>HRPK1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform e of Heterogeneous nuclear ribonucleoprotein K homolog</fullName>
            <shortName evidence="1">hnRNP K</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrpk-1</name>
        <name evidence="3" type="ORF">F26B1.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2005" name="Genetics" volume="169" first="1451" last="1460">
            <title>Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Holway A.H."/>
                <person name="Hung C."/>
                <person name="Michael W.M."/>
            </authorList>
            <dbReference type="PubMed" id="15654100"/>
            <dbReference type="DOI" id="10.1534/genetics.104.036137"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2019" name="PLoS Genet." volume="15" first="E1008067" last="E1008067">
            <title>HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development.</title>
            <authorList>
                <person name="Li L."/>
                <person name="Veksler-Lublinsky I."/>
                <person name="Zinovyeva A."/>
            </authorList>
            <dbReference type="PubMed" id="31584932"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1008067"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ALG-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P91277-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060459"/>
        </isoform>
        <isoform>
            <id>P91277-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P91277-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060456 VSP_060454 VSP_060457"/>
        </isoform>
        <isoform>
            <id>P91277-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060454"/>
        </isoform>
        <isoform>
            <id>P91277-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060455 VSP_060454 VSP_060458"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379660.1">
        <property type="nucleotide sequence ID" value="NM_001392429.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F26B1.2e">
        <property type="protein sequence ID" value="CE33060"/>
        <property type="gene ID" value="WBGene00017816"/>
        <property type="gene designation" value="hrpk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F26B1.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F26B1.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F26B1.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F26B1.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F26B1.2e"/>
        </source>
    </evidence>
    <sequence length="93" mass="10185" checksum="BF21621B241E1161" modified="1997-05-01" version="1">MMIKVGAAINGTDSPKAMKREHDNDDGDRTGRHKRPKTDGFTEAIQQGKFEVRLLVSSKSAGAIIGKGGENIKRLRAEFNAHVQVPDSNTPER</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q18227</accession>
    <name>Q18227_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine 5'-monophosphoramidase HINT3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Histidine triad nucleotide-binding protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">hint-3</name>
        <name evidence="12" type="ORF">C26F1.7</name>
        <name evidence="10" type="ORF">CELE_C26F1.7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD65772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T15638">
        <property type="entry name" value="T15638"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256090.1">
        <property type="nucleotide sequence ID" value="NM_001269161.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18227"/>
    <dbReference type="SMR" id="Q18227"/>
    <dbReference type="PeptideAtlas" id="Q18227"/>
    <dbReference type="GeneID" id="182943"/>
    <dbReference type="AGR" id="WB:WBGene00016150"/>
    <dbReference type="CTD" id="182943"/>
    <dbReference type="WormBase" id="C26F1.7a">
        <property type="protein sequence ID" value="CE06881"/>
        <property type="gene ID" value="WBGene00016150"/>
        <property type="gene designation" value="hint-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_4_0_1"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="PhylomeDB" id="Q18227"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016150">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18227">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01278">
        <property type="entry name" value="aprataxin_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="9">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="7">
        <location>
            <begin position="109"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD65772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C26F1.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="Q18227"/>
        </source>
    </evidence>
    <sequence length="175" mass="19791" checksum="1C950EDC6B920AF8" modified="1996-11-01" version="1">MTSMHTSVNGCKFCDIVKNKKELQLKENKSCVVINDIKPKAKNHYLVLSKQHIAKPTDLTVADVPLLEEMEKTGRELLREHLKKKGEADTVEDMLRIGFHLPPLLSVHHLHMHIIYPISDMGLISRKLTFRPGKVFKPARELIDQLKEDAGVPDPLEGNPAKDDVHEKIPAQVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q19515</accession>
    <name>Q19515_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F17C11.4</name>
        <name evidence="1 3" type="ORF">F17C11.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA96626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21056">
        <property type="entry name" value="T21056"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19515"/>
    <dbReference type="UCSC" id="F17C11.4">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008915"/>
    <dbReference type="WormBase" id="F17C11.4a">
        <property type="protein sequence ID" value="CE05651"/>
        <property type="gene ID" value="WBGene00008915"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097290_0_0_1"/>
    <dbReference type="OrthoDB" id="5776386at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008915">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q19515">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA96626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F17C11.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="Q19515"/>
        </source>
    </evidence>
    <sequence length="175" mass="19337" checksum="2BA46C7014553E9A" modified="1996-11-01" version="1">MPRQRRQGIVYDVREQGTARLIFDENRTKFDGVLETISGETMLVRGRVTSPTDLASTSATTDGSIVMDIDVVDGEEGSAFHVTGVKVLVDEHYAAIDSTAIKFEALDRLIGMKAAVEIQQHISPEIAYDSKEVFIGKMQIHLLTSHRPSPSSRRESVCAENNDIKILEVSDDFLA</sequence>
</entry>
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    <accession>Q19561</accession>
    <name>Q19561_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">CELE_F18E3.4</name>
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    <organism evidence="7 8">
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD69658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29216">
        <property type="entry name" value="T29216"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q19561"/>
    <dbReference type="GeneID" id="184640"/>
    <dbReference type="KEGG" id="cel:CELE_F18E3.4"/>
    <dbReference type="UCSC" id="F18E3.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00005815"/>
    <dbReference type="CTD" id="184640"/>
    <dbReference type="WormBase" id="F18E3.4a">
        <property type="protein sequence ID" value="CE34820"/>
        <property type="gene ID" value="WBGene00005815"/>
        <property type="gene designation" value="srw-68"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5862069at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22751:SF54">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="48"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD69658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F18E3.4a"/>
        </source>
    </evidence>
    <sequence length="338" mass="38819" checksum="1947B374526E89FD" modified="2003-10-01" version="4">MKIVFPLDVEGLDESTINNLMSIGNSISKIKESSLNIFFVLSCVGVVVNIFHLFILTRKSMVNNSIHVMMIGISVCDLLLMSLGVYGHFDFLLRNNDECSPPQSYVYKLFEFWRKALQDHSRRVSAWYGVMMALMRLLIVKFVLNPKFDILSKPLFSYIFMSVAFIVSSGMTLYFWVCFEYITMEIWNPPKQCTGFPPNFSMPRYKSSLEDISLIKHRADLLIFVFIDGFFKIIPAIMFPIITFLLIKQLRAANSKRRQISQRNGSENRKIGFGLIDILAIFVALNATIHCLICLTVSSHYRKTVKDVFKCCRKNSITKIEPTVPGKSFTMVKQKAME</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="160" xmlns="https://uniprot.org/uniprot">
    <accession>Q19565</accession>
    <name>Q19565_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">jmjd-3.1</name>
        <name evidence="13" type="ORF">CELE_F18E9.5</name>
        <name evidence="15" type="ORF">F18E9.5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UTX family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD68427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001381042.1"/>
    </dbReference>
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    <dbReference type="SMR" id="Q19565"/>
    <dbReference type="GeneID" id="181111"/>
    <dbReference type="UCSC" id="F18E9.5a.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017571"/>
    <dbReference type="CTD" id="181111"/>
    <dbReference type="WormBase" id="F18E9.5a">
        <property type="protein sequence ID" value="CE30957"/>
        <property type="gene ID" value="WBGene00017571"/>
        <property type="gene designation" value="jmjd-3.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_296162_0_0_1"/>
    <dbReference type="OrthoDB" id="5876455at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017571">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q19565">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Lysine-specific demethylase jmjd-3.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF29">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="JmjC" evidence="12">
        <location>
            <begin position="719"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="215"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD68427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F18E9.5a"/>
        </source>
    </evidence>
    <sequence length="1020" mass="115959" checksum="F4118CDCFCAC2147" modified="2002-10-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q20508</accession>
    <name>Q20508_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F47B10.8</name>
        <name evidence="2 4" type="ORF">F47B10.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAA91988.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T22339">
        <property type="entry name" value="T22339"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257124.1">
        <property type="nucleotide sequence ID" value="NM_001270195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q20508"/>
    <dbReference type="IntAct" id="Q20508">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="181282"/>
    <dbReference type="UCSC" id="F47B10.8">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009819"/>
    <dbReference type="CTD" id="181282"/>
    <dbReference type="WormBase" id="F47B10.8a">
        <property type="protein sequence ID" value="CE32424"/>
        <property type="gene ID" value="WBGene00009819"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843182at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009819">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q20508">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851:SF3">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851">
        <property type="entry name" value="PROTEIN CBG05235-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA91988.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F47B10.8a"/>
        </source>
    </evidence>
    <sequence length="237" mass="27285" checksum="5F038B8E412C41F8" modified="2003-03-01" version="2">MSKDRNIIYYRDLYYYTVMFADANGNENGNGNGIMKTPQRETVVSLGFTEDPIPPNSYCCNSCHIQKACRAVAVFAFLGFIINLVLYFMGISKLGLNGYLEAFLLIFDCISLLTLFCGVSKQRSGLLKPYLFYNVIWNFGMIILFLVFVYHMLKGTSDVSRNILDNLKALRSNPDEYHFRSRESVTTAILVTLGVMAAMSFVIVINCIFLHVVYRTFQFFAYQEDKKREEMDKKERL</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="167" xmlns="https://uniprot.org/uniprot">
    <accession>Q20514</accession>
    <name>Q20514_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="10">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CELE_F47B7.2</name>
        <name evidence="13 15" type="ORF">F47B7.2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="10"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD70491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T16384">
        <property type="entry name" value="T16384"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508654.1">
        <property type="nucleotide sequence ID" value="NM_076253.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q20514"/>
    <dbReference type="SMR" id="Q20514"/>
    <dbReference type="PeptideAtlas" id="Q20514"/>
    <dbReference type="GeneID" id="180664"/>
    <dbReference type="UCSC" id="F47B7.2c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018533"/>
    <dbReference type="CTD" id="180664"/>
    <dbReference type="WormBase" id="F47B7.2a">
        <property type="protein sequence ID" value="CE04599"/>
        <property type="gene ID" value="WBGene00018533"/>
    </dbReference>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018533">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q20514">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02992">
        <property type="entry name" value="PDI_a_QSOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000005">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000425">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1960">
        <property type="entry name" value="QSOX sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040986">
        <property type="entry name" value="QSOX_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042568">
        <property type="entry name" value="QSOX_FAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF26">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18371">
        <property type="entry name" value="FAD_SOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="11">
        <location>
            <begin position="410"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD70491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F47B7.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="Q20514"/>
        </source>
    </evidence>
    <sequence length="623" mass="70155" checksum="063F31D9CFBF608C" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>Q20518</accession>
    <name>Q20518_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F47B8.4</name>
        <name evidence="2 4" type="ORF">F47B8.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB01193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T22342">
        <property type="entry name" value="T22342"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256579.1">
        <property type="nucleotide sequence ID" value="NM_001269650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q20518"/>
    <dbReference type="SMR" id="Q20518"/>
    <dbReference type="GeneID" id="179930"/>
    <dbReference type="UCSC" id="F47B8.4">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009805"/>
    <dbReference type="CTD" id="179930"/>
    <dbReference type="WormBase" id="F47B8.4a">
        <property type="protein sequence ID" value="CE10638"/>
        <property type="gene ID" value="WBGene00009805"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1095093_0_0_1"/>
    <dbReference type="OrthoDB" id="5801693at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009805">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q20518">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007007"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB01193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F47B8.4a"/>
        </source>
    </evidence>
    <sequence length="248" mass="29032" checksum="71F186AD3A44CF84" modified="1996-11-01" version="1">MIQLRVQFLHFQSIFYHQNKAKIEHEKKSLNVIIIVVQNQIDDIKLIVGEYFKIKNLQMLKTIIDSFEYTLNKIAFEISKAKGQNFFIEKVEKLINNLNPFDVPIYENIQGVVLELNTQVSSMGNIPEKLEIKTQRETFQLEEENEIRMDNCRMMSGQAKIYKIFRKSVVLFVNYLEDEQTLSTIQSLNDNQIEYTIFDVSTDSEIRFISKALSDCETFPQLFVDGAFEPLPILKNLLPKLPKVYTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q20558</accession>
    <name>Q20558_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">gap-1</name>
        <name evidence="2" type="ORF">CELE_T24C12.2</name>
        <name evidence="4" type="ORF">T24C12.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD68820.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508403.2">
        <property type="nucleotide sequence ID" value="NM_076002.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q20558"/>
    <dbReference type="SMR" id="Q20558"/>
    <dbReference type="FunCoup" id="Q20558">
        <property type="interactions" value="1218"/>
    </dbReference>
    <dbReference type="PaxDb" id="6239-F48B9.1"/>
    <dbReference type="GeneID" id="180530"/>
    <dbReference type="UCSC" id="F48B9.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001515"/>
    <dbReference type="CTD" id="180530"/>
    <dbReference type="WormBase" id="T24C12.2c">
        <property type="protein sequence ID" value="CE46654"/>
        <property type="gene ID" value="WBGene00001515"/>
        <property type="gene designation" value="gap-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TFWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489390_0_0_1"/>
    <dbReference type="InParanoid" id="Q20558"/>
    <dbReference type="OMA" id="ICIDIRR"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018587">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD68820.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T24C12.2c"/>
        </source>
    </evidence>
    <sequence length="490" mass="54881" checksum="BD1482F7DF1589EE" modified="2012-01-25" version="2">MSRSNENNAEFDHVENDTDEQDNDASCQDQVSQTDPIENGIVIEEIKDHEENKSPISLIVSPDGSENSTEEFNSLNVSLLPPSERKPSRNLEDIDRTLDELQDLAEDAFLTAQMAQGNQAKLFDKLFESSTVYLKKCETVPEDLTKQQFSDEDGILEEIEEAVRDAEEKQYEPNHVSVVLDTECSSDDEVASDRYPGVGNIDQLRHDDNSLRNVGGHRVRQRVASNATLNDRRSIISGHERARSNDSRATSLFSSSIASFRRPISHFSIDNSCFDINDPPTQRSLMCTPVEKMFVKNSRSAPEMRVHETKIQPFLPSPSPSNDATTTTSDPSVSSEISMEQPIQPIVSNLKLRLSEGLSETVSPAASPIVKTKSRKEKKTNQQMLKGSASSPNMNSQNLIINRKTTEADVENDKPKPNTNRTFEVVTVSVVNVDFARKPKKSVYIMAKFDGKDVHRSSKLRSDNLVHDFSVETTNSFSNLHLVFLEGWFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2026-01-28" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>Q21067-2</accession>
    <name>IFC2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Intermediate filament protein ifc-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cel IF C2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Intermediate filament protein C2</fullName>
            <shortName>IF-C2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ifc-2</name>
        <name type="ORF">M6.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="EMBO J." volume="13" first="2625" last="2638">
            <title>Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dodemont H."/>
                <person name="Riemer D."/>
                <person name="Ledger T.N."/>
                <person name="Weber K."/>
            </authorList>
            <dbReference type="PubMed" id="8013462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND B)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Proc. Natl. Acad. Sci. U.S.A." volume="98" first="7863" last="7868">
            <title>Essential roles for four cytoplasmic intermediate filament proteins in Caenorhabditis elegans development.</title>
            <authorList>
                <person name="Karabinos A."/>
                <person name="Schmidt H."/>
                <person name="Harborth J."/>
                <person name="Schnabel R."/>
                <person name="Weber K."/>
            </authorList>
            <dbReference type="PubMed" id="11427699"/>
            <dbReference type="DOI" id="10.1073/pnas.121169998"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="Mech. Dev." volume="117" first="311" last="314">
            <title>Expression profiles of the essential intermediate filament (IF) protein A2 and the IF protein C2 in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Karabinos A."/>
                <person name="Schulze E."/>
                <person name="Klisch T."/>
                <person name="Wang J."/>
                <person name="Weber K."/>
            </authorList>
            <dbReference type="PubMed" id="12204276"/>
            <dbReference type="DOI" id="10.1016/S0925-4773(02)00192-2"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21067-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_010149 VSP_010150"/>
        </isoform>
        <isoform>
            <id>Q21067-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001380259.1">
        <property type="nucleotide sequence ID" value="NM_001392719.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="502" mass="56208" checksum="A9F468EA955ACFA7" modified="2004-04-26" version="3">MSTYAAYTTSTYQGRGLASGTYASGFGQLVSGMSSAGAICTTQIRDAREREKREIGLLNDRLADYIEKVRFLEAQNRCLSHDIDILRNGFSGGGHVSGLFDAEINQAKHILEQTTAHRSTFERDITGLSAEIEVFRKKWLDAVNAVKAHREDHDVDLDRLAKIEAEISLFKRKIRIVEEDVIRIRRENDGIYNEIARIKQLTHNEIALKNERSLNVSDLLQRINLLQTENNVRIEQELVFIRRDTTADNRDYFRHELQAAIRDIRADYEAISIRNRQDIEVWYREQIRKIQDESVRVNPDLYKEELISIRTTVTNVRSRLAEVEGRNFFLERLIDDLKNNEEAKFFEISLAERDAQIATLRDQCTELSIQMEKLCDNEISLRAEIERYRILLNGANVTTYTSNTHGSGSGIAVGGVVGGSTRVISQTTRTHSSSNTSYSNVPASRGGYSISGNVGGISVGGTIGSHGASAHATGGIIGSGVQAHRGSGTYQQSHHSYSSSNH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="191" xmlns="https://uniprot.org/uniprot">
    <accession>Q21187-2</accession>
    <name>FKH9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform b of Forkhead transcription factor fkh-9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fkh-9</name>
        <name evidence="3" type="ORF">K03C7.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2016" name="Dev. Biol." volume="413" first="112" last="127">
            <title>A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-beta/Sma/Mab pathway.</title>
            <authorList>
                <person name="Goszczynski B."/>
                <person name="Captan V.V."/>
                <person name="Danielson A.M."/>
                <person name="Lancaster B.R."/>
                <person name="McGhee J.D."/>
            </authorList>
            <dbReference type="PubMed" id="26963674"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2016.02.031"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2016" name="Nature" volume="529" first="92" last="96">
            <title>The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.</title>
            <authorList>
                <person name="Kaletsky R."/>
                <person name="Lakhina V."/>
                <person name="Arey R."/>
                <person name="Williams A."/>
                <person name="Landis J."/>
                <person name="Ashraf J."/>
                <person name="Murphy C.T."/>
            </authorList>
            <dbReference type="PubMed" id="26675724"/>
            <dbReference type="DOI" id="10.1038/nature16483"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2018" name="Genetics" volume="210" first="1329" last="1337">
            <title>Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tillman E.J."/>
                <person name="Richardson C.E."/>
                <person name="Cattie D.J."/>
                <person name="Reddy K.C."/>
                <person name="Lehrbach N.J."/>
                <person name="Droste R."/>
                <person name="Ruvkun G."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30287474"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301450"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF GLY-111</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21187-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_061275"/>
        </isoform>
        <isoform>
            <id>Q21187-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q21187-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_061276"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024761.1">
        <property type="nucleotide sequence ID" value="NM_001029590.7"/>
    </dbReference>
    <dbReference type="WormBase" id="K03C7.2b">
        <property type="protein sequence ID" value="CE34332"/>
        <property type="gene ID" value="WBGene00001441"/>
        <property type="gene designation" value="fkh-9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="K03C7.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="K03C7.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="K03C7.2c"/>
        </source>
    </evidence>
    <sequence length="280" mass="31113" checksum="D3A0963C016E815D" modified="2002-10-01" version="2">MDLLRSPIQIPSASDTIKIETPSTISSQPSPIQTPLAAASSDNFERPSLSYKDLIIEAIDRSPEKRLKLNEIYQVIRLLHPYYRHRPDQWGWQNSIRHNLSLHDCFVKLPLKQTSASGVVGHFWTVVPELSDKQTLRRRNRQQPRALAKKSDAGRTLSRDDRGSSGSGETSPSPSQPSISPPNENPMPSVQALNVLELLSGMNDYKGTLFQNNYRTNLIQDNSAVNGLQNLLTTTLMQINPQLGALLSLANLNNLTTNQLQIASPSLSPIKAESQSFLLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="191" xmlns="https://uniprot.org/uniprot">
    <accession>Q21187-3</accession>
    <name>FKH9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform c of Forkhead transcription factor fkh-9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fkh-9</name>
        <name evidence="3" type="ORF">K03C7.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2016" name="Dev. Biol." volume="413" first="112" last="127">
            <title>A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-beta/Sma/Mab pathway.</title>
            <authorList>
                <person name="Goszczynski B."/>
                <person name="Captan V.V."/>
                <person name="Danielson A.M."/>
                <person name="Lancaster B.R."/>
                <person name="McGhee J.D."/>
            </authorList>
            <dbReference type="PubMed" id="26963674"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2016.02.031"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2016" name="Nature" volume="529" first="92" last="96">
            <title>The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.</title>
            <authorList>
                <person name="Kaletsky R."/>
                <person name="Lakhina V."/>
                <person name="Arey R."/>
                <person name="Williams A."/>
                <person name="Landis J."/>
                <person name="Ashraf J."/>
                <person name="Murphy C.T."/>
            </authorList>
            <dbReference type="PubMed" id="26675724"/>
            <dbReference type="DOI" id="10.1038/nature16483"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2018" name="Genetics" volume="210" first="1329" last="1337">
            <title>Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tillman E.J."/>
                <person name="Richardson C.E."/>
                <person name="Cattie D.J."/>
                <person name="Reddy K.C."/>
                <person name="Lehrbach N.J."/>
                <person name="Droste R."/>
                <person name="Ruvkun G."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30287474"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301450"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF GLY-111</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21187-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_061276"/>
        </isoform>
        <isoform>
            <id>Q21187-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q21187-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_061275"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379922.1">
        <property type="nucleotide sequence ID" value="NM_001392752.1"/>
    </dbReference>
    <dbReference type="WormBase" id="K03C7.2c">
        <property type="protein sequence ID" value="CE39581"/>
        <property type="gene ID" value="WBGene00001441"/>
        <property type="gene designation" value="fkh-9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="K03C7.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="K03C7.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="K03C7.2c"/>
        </source>
    </evidence>
    <sequence length="94" mass="10246" checksum="F22658762F7C5B7D" modified="2002-10-01" version="2">MPSVQALNVLELLSGMNDYKGTLFQNNYRTNLIQDNSAVNGLQNLLTTTLMQINPQLGALLSLANLNNLTTNQLQIASPSLSPIKAESQSFLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q21843</accession>
    <name>Q21843_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WAPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">wapl-1</name>
        <name evidence="4" type="ORF">CELE_R08C7.10</name>
        <name evidence="6" type="ORF">R08C7.10</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD73091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29661">
        <property type="entry name" value="T29661"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_500567.1">
        <property type="nucleotide sequence ID" value="NM_068166.8"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q21843"/>
    <dbReference type="SMR" id="Q21843"/>
    <dbReference type="GeneID" id="177211"/>
    <dbReference type="AGR" id="WB:WBGene00019953"/>
    <dbReference type="CTD" id="177211"/>
    <dbReference type="WormBase" id="R08C7.10a">
        <property type="protein sequence ID" value="CE07433"/>
        <property type="gene ID" value="WBGene00019953"/>
        <property type="gene designation" value="wapl-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019953">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q21843">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="3">
        <location>
            <begin position="203"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD73091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="R08C7.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q21843"/>
        </source>
    </evidence>
    <sequence length="746" mass="84091" checksum="20DD20F6576AA479" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-10-25" modified="2025-10-08" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q3LQX0</accession>
    <name>Q3LQX0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear Hormone Receptor family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">nhr-105</name>
        <name evidence="17" type="ORF">C06G3.1</name>
        <name evidence="15" type="ORF">CELE_C06G3.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD83548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021304.1">
        <property type="nucleotide sequence ID" value="NM_001026133.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q3LQX0"/>
    <dbReference type="SMR" id="Q3LQX0"/>
    <dbReference type="GeneID" id="177476"/>
    <dbReference type="UCSC" id="C06G3.1a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003695"/>
    <dbReference type="CTD" id="177476"/>
    <dbReference type="WormBase" id="C06G3.1b">
        <property type="protein sequence ID" value="CE37188"/>
        <property type="gene ID" value="WBGene00003695"/>
        <property type="gene designation" value="nhr-105"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007368_3_3_1"/>
    <dbReference type="OrthoDB" id="5783820at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003695">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q3LQX0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587:SF6">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="147"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD83548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C06G3.1b"/>
        </source>
    </evidence>
    <sequence length="413" mass="47075" checksum="A3EF65D83F695358" modified="2005-10-25" version="1">MTFSDPMDPSIPIFQHHEEEEAGPSTTIKAEEEDGPCCLVCGRVANTGHHYGVTACLGCKTFFRRVVLQKNSPKCKYKNHCRLEKSVNAKRLCRSCRYQKCLEVGMTEDALHPCRDVIGRRVRNNSSDSSPISSPPSIPTPLSTITDMDTDIRTRTAHILGEPANGNEQIHFYSPTPDYTNVIVNHGIGPSLKVDILLLREWVDRIPGFRELSERFQQHLMHRFCLRYTVIEHGLFTAQMPYHKNVWFLSDRTCLVSEFENLPQEIKKHLTPKVINEQQLLASFTEMLIHEVADPLRRLKPDSVEVATVKTLMLLKPTCLREIDGDYLSTETDIKSVNDVRNRVINGLYSHYIKNGMDPEQLPIRVSEILNLTGGVEQCAARALEEMHPTRVFNLSSFDPYSSNVIFGYYRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q56VX4</accession>
    <name>Q56VX4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tight junction protein ZO-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">zoo-1</name>
        <name evidence="5" type="ORF">CELE_Y105E8A.26</name>
        <name evidence="7" type="ORF">Y105E8A.26</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAI79187.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001364648.1">
        <property type="nucleotide sequence ID" value="NM_001377679.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q56VX4"/>
    <dbReference type="SMR" id="Q56VX4"/>
    <dbReference type="GeneID" id="173316"/>
    <dbReference type="UCSC" id="Y105E8A.26b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013683"/>
    <dbReference type="CTD" id="173316"/>
    <dbReference type="WormBase" id="Y105E8A.26b">
        <property type="protein sequence ID" value="CE53794"/>
        <property type="gene ID" value="WBGene00013683"/>
        <property type="gene designation" value="zoo-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001538_3_0_1"/>
    <dbReference type="OrthoDB" id="418634at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013683">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q56VX4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd06727">
        <property type="entry name" value="PDZ1_ZO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06728">
        <property type="entry name" value="PDZ2_ZO1-like_ds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06729">
        <property type="entry name" value="PDZ3_ZO1-like_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11859">
        <property type="entry name" value="SH3_ZO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000138">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000303">
        <property type="entry name" value="ZO-1 (Zonula Occludens tight junctional protein) Ortholog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002258">
        <property type="entry name" value="ZO-1 (Zonula Occludens tight junctional protein) Ortholog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865:SF28">
        <property type="entry name" value="POLYCHAETOID, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865">
        <property type="entry name" value="TIGHT JUNCTION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="45"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="325"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="2">
        <location>
            <begin position="588"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="851"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAI79187.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y105E8A.26b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q56VX4"/>
        </source>
    </evidence>
    <sequence length="1124" mass="124196" checksum="AF73CB9F127ADA83" modified="2020-04-22" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-17" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ52-2</accession>
    <name>BBS4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of BBSome complex member bbs-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Bardet-Biedl syndrome 4 protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bbs-4</name>
        <name evidence="2" type="ORF">F58A4.14</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="Nat. Cell Biol." volume="14" first="950" last="957">
            <title>The BBSome controls IFT assembly and turnaround in cilia.</title>
            <authorList>
                <person name="Wei Q."/>
                <person name="Zhang Y."/>
                <person name="Li Y."/>
                <person name="Zhang Q."/>
                <person name="Ling K."/>
                <person name="Hu J."/>
            </authorList>
            <dbReference type="PubMed" id="22922713"/>
            <dbReference type="DOI" id="10.1038/ncb2560"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11855" last="11855">
            <title>BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors.</title>
            <authorList>
                <person name="Xu Q."/>
                <person name="Zhang Y."/>
                <person name="Wei Q."/>
                <person name="Huang Y."/>
                <person name="Li Y."/>
                <person name="Ling K."/>
                <person name="Hu J."/>
            </authorList>
            <dbReference type="PubMed" id="26150102"/>
            <dbReference type="DOI" id="10.1038/srep11855"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH BBS-5</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-107 AND ALA-388</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q5CZ52-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_044208"/>
        </isoform>
        <isoform>
            <id>Q5CZ52-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255014.1">
        <property type="nucleotide sequence ID" value="NM_001268085.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F58A4.14b">
        <property type="protein sequence ID" value="CE46292"/>
        <property type="gene ID" value="WBGene00043992"/>
        <property type="gene designation" value="bbs-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F58A4.14a"/>
        </source>
    </evidence>
    <sequence length="310" mass="34300" checksum="03689AE304FC2FF0" modified="2012-10-03" version="2">MKDNPKVWYWLARAIYHFPAEKVQGKTFNPVESARTILMKPDIAKDATLICFLGRLCEELGDTSGAIAAYKSSLKLQPDNTEVMNLLGLIYLRTGQVQEGFVQLGNCLAYDPANSQAILTIGSIMQNHSDHDVALNKYRVAADVSDYNGCLWNNIGIGLLARNKPAASHSALKKAAFINPLNYKISYNLGVLHDIMNLHCSALHYIKLCTELYPQNAKAVGAMAVILSHMNDDKNARLAYKKSIELKKNPSTILNYAIFEYRMKDVTAASNALKLYKDLQASGVKCSANNKETANLLESVLKQPDQSAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2025-10-08" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q69Z09</accession>
    <name>Q69Z09_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cec-7</name>
        <name evidence="3" type="ORF">CELE_Y37D8A.11</name>
        <name evidence="5" type="ORF">Y37D8A.11</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAH10813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022828.1">
        <property type="nucleotide sequence ID" value="NM_001027657.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q69Z09"/>
    <dbReference type="SMR" id="Q69Z09"/>
    <dbReference type="PeptideAtlas" id="Q69Z09"/>
    <dbReference type="GeneID" id="176704"/>
    <dbReference type="UCSC" id="Y37D8A.11a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012551"/>
    <dbReference type="CTD" id="176704"/>
    <dbReference type="WormBase" id="Y37D8A.11b">
        <property type="protein sequence ID" value="CE37167"/>
        <property type="gene ID" value="WBGene00012551"/>
        <property type="gene designation" value="cec-7"/>
    </dbReference>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
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        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:chromatin organization"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="C.Elegans Chromodomain protein"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF49">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="246"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="351"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH10813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y37D8A.11b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q69Z09"/>
        </source>
    </evidence>
    <sequence length="406" mass="44823" checksum="006FB8AF23919943" modified="2004-09-13" version="1">MAPNRTPKQNFAIGEDITCVYKTHPYDATIIGIENNREGKECYCVHFKGWNCRYDEKIVIGEEKDRIFKGTVEDYYKKSHKTVVTAVVAGKQKQTASSSADSNGTSSGATEKAAKAPAATMRKSAKKVGESNSEATDPEAKAKESSQSALKVEPPLTTHNSSRKTVEATGAMKRLTVAKETEDEALKSQKKARIEPVEDASKAKGSAAPKSASSRAEDGESSSTNDAAGTRFVIGELVACTYKGKVYDAVITDIKPDKDGKECYCIHFKGWNNRYDEQIPIGEETDRIFKGIADGYRAPVVTMRKSARNHEKSTEPQATKENAPRLVGKRREQFIIGEQVTCTQNGKPYDAYIVDIITDTDGKDFYCVHFKGWNSRYDEKIPVGEEQGRLFKGSAAKYAEMLEMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q69Z10</accession>
    <name>Q69Z10_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_T06G6.3</name>
        <name evidence="3 5" type="ORF">T06G6.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAH10780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021615.1">
        <property type="nucleotide sequence ID" value="NM_001026444.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q69Z10"/>
    <dbReference type="SMR" id="Q69Z10"/>
    <dbReference type="GeneID" id="173139"/>
    <dbReference type="UCSC" id="T06G6.3b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011545"/>
    <dbReference type="CTD" id="173139"/>
    <dbReference type="WormBase" id="T06G6.3b">
        <property type="protein sequence ID" value="CE37142"/>
        <property type="gene ID" value="WBGene00011545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011545">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q69Z10">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH10780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T06G6.3b"/>
        </source>
    </evidence>
    <sequence length="483" mass="56430" checksum="BD69C4074C44DE09" modified="2004-09-13" version="1">MTESWSQVFNNPISAADYFFAESLKLQQRNNLLEMEVVEEKAANTMLRNDLKNCKGMLKEQEELLAAEKRKSPVPGDQESEDTTVYLSRGICMMHREWMLERKEQQDKLLLLSGSLEMERQQTAETCEIITMLEAELEQEQADAKKKQKSLNREIEKLKERIEKMAAEEPEQEAKKDVCKRNVNHFKLDETCPIQIIKSERIKVAQNEIRELNKQLDAEQDPLKKLEYMDSIREKASLIAQEAMDHAELLNSVLDYERDAHTEIRHRQLRKQKKEIEKLIGEWKVKEKEHQNDMCKLAQQILDQALEFKASNKARAKEHPASSKSEEQSSNKEILSSLEAKLKKEQDDHLVTTNQLNYQSAILNEAQSEIKKLEQLILKNSEELESLQTWKSDSTIREQNLMDENCKQYVDICDLQNTIRGLRFADTRWMEEHLKLNEQVDSMKQGFELVDTGYGPTQGTFGVVEKKKAEEEVTVEEEDYEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2025-10-08" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q69Z13</accession>
    <name>Q69Z13_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 9">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">rml-1</name>
        <name evidence="12" type="ORF">CELE_K08E3.5</name>
        <name evidence="14" type="ORF">K08E3.5</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19890"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 9"/>
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        <property type="protein sequence ID" value="CAH10810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022671.1">
        <property type="nucleotide sequence ID" value="NM_001027500.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q69Z13"/>
    <dbReference type="SMR" id="Q69Z13"/>
    <dbReference type="IntAct" id="Q69Z13">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q69Z13"/>
    <dbReference type="GeneID" id="176814"/>
    <dbReference type="KEGG" id="cel:CELE_K08E3.5"/>
    <dbReference type="UCSC" id="K08E3.5f">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010665"/>
    <dbReference type="CTD" id="176814"/>
    <dbReference type="WormBase" id="K08E3.5f">
        <property type="protein sequence ID" value="CE37125"/>
        <property type="gene ID" value="WBGene00010665"/>
        <property type="gene designation" value="rml-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023632_3_0_1"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010665">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q69Z13">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH10810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="K08E3.5f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q69Z13"/>
        </source>
    </evidence>
    <sequence length="493" mass="54962" checksum="BD89CDCFD61B49EF" modified="2004-09-13" version="1">MPSSEEWKTSTKLEALGSMEGELAHLLSTCKPETLNHNKTELSGFRNLFARFLRAKPTVDWSKIEPLPEGAIRPYKSLGHVVDKELIASQLRKLVVVKLNGGLGTSMGCKGPKSVISVRNDLTFLDLTMQQIQTLNKTYGVDVPLVLMNSFNTNEDTQKVLKKYANVKVSVHTFSQSQYPRINRETLLPIVKSLEADDNECWYPPGHGNFYEAFHNSGLLDKFLADGKEYCFLSNIDNMGATVDLSILNFVLNPSPDQTAPEFLMEVTDKTRADVKGGTLIQYEGRLMLLEIAQVPKDYVDEFKSISKFRIFNTNNLWAKLDAMRKIVVENKLEMEVIVNPKHLDRGLDVIQLETAAGAAIKSFSGAVGVNVPRSRFLPVKKTSDLLLLMSNLYDIDNGSLTLSHQRSFPTTPLVKLGSSFDKVKDYLGRFNGIPDLLELDHLTVSGDVWFGKDVSLKGTVIIIANHGDRIDIPPGSILENKIVSGNLRILEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>Q86D21</accession>
    <name>Q86D21_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">tars-1</name>
        <name evidence="16" type="ORF">C47D12.6</name>
        <name evidence="14" type="ORF">CELE_C47D12.6</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAD89723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379393.1">
        <property type="nucleotide sequence ID" value="NM_001393202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86D21"/>
    <dbReference type="SMR" id="Q86D21"/>
    <dbReference type="PeptideAtlas" id="Q86D21"/>
    <dbReference type="GeneID" id="174790"/>
    <dbReference type="UCSC" id="C47D12.6b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006617"/>
    <dbReference type="CTD" id="174790"/>
    <dbReference type="WormBase" id="C47D12.6b">
        <property type="protein sequence ID" value="CE33765"/>
        <property type="gene ID" value="WBGene00006617"/>
        <property type="gene designation" value="tars-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_1"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006617">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86D21">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase mitochondrial 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="13">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="299"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAD89723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="C47D12.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="Q86D21"/>
        </source>
    </evidence>
    <sequence length="684" mass="79464" checksum="DBE1A790C1750389" modified="2003-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QA6-2</accession>
    <name>PAT12_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Protein pat-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Paralyzed arrest at two-fold 12 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pat-12</name>
        <name evidence="3" type="ORF">T17H7.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Dev. Biol." volume="350" first="267" last="278">
            <title>PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.</title>
            <authorList>
                <person name="Hetherington S."/>
                <person name="Gally C."/>
                <person name="Fritz J.A."/>
                <person name="Polanowska J."/>
                <person name="Reboul J."/>
                <person name="Schwab Y."/>
                <person name="Zahreddine H."/>
                <person name="Behm C."/>
                <person name="Labouesse M."/>
            </authorList>
            <dbReference type="PubMed" id="21130760"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.11.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH VAB-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95QA6-11</id>
            <name evidence="12">k</name>
            <sequence type="described" ref="VSP_058354"/>
        </isoform>
        <isoform>
            <id>Q95QA6-8</id>
            <name evidence="9">h</name>
            <sequence type="described" ref="VSP_058361 VSP_058353 VSP_058358"/>
        </isoform>
        <isoform>
            <id>Q95QA6-10</id>
            <name evidence="11">j</name>
            <sequence type="described" ref="VSP_058355"/>
        </isoform>
        <isoform>
            <id>Q95QA6-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_058356"/>
        </isoform>
        <isoform>
            <id>Q95QA6-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_058357"/>
        </isoform>
        <isoform>
            <id>Q95QA6-7</id>
            <name evidence="8">g</name>
            <sequence type="described" ref="VSP_058352 VSP_058359"/>
        </isoform>
        <isoform>
            <id>Q95QA6-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_058360"/>
        </isoform>
        <isoform>
            <id>Q95QA6-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_058359 VSP_058361 VSP_058353"/>
        </isoform>
        <isoform>
            <id>Q95QA6-9</id>
            <name evidence="10">i</name>
            <sequence type="described" ref="VSP_058361 VSP_058353 VSP_058357"/>
        </isoform>
        <isoform>
            <id>Q95QA6-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367550.1">
        <property type="nucleotide sequence ID" value="NM_001381698.1"/>
    </dbReference>
    <dbReference type="WormBase" id="T17H7.4b">
        <property type="protein sequence ID" value="CE28671"/>
        <property type="gene ID" value="WBGene00003936"/>
        <property type="gene designation" value="pat-12"/>
    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T17H7.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T17H7.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T17H7.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T17H7.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T17H7.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T17H7.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T17H7.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T17H7.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T17H7.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T17H7.4k"/>
        </source>
    </evidence>
    <sequence length="603" mass="69925" checksum="DE48ED93417450E8" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QA6-3</accession>
    <name>PAT12_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Protein pat-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Paralyzed arrest at two-fold 12 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pat-12</name>
        <name evidence="3" type="ORF">T17H7.4</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Dev. Biol." volume="350" first="267" last="278">
            <title>PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.</title>
            <authorList>
                <person name="Hetherington S."/>
                <person name="Gally C."/>
                <person name="Fritz J.A."/>
                <person name="Polanowska J."/>
                <person name="Reboul J."/>
                <person name="Schwab Y."/>
                <person name="Zahreddine H."/>
                <person name="Behm C."/>
                <person name="Labouesse M."/>
            </authorList>
            <dbReference type="PubMed" id="21130760"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.11.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH VAB-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95QA6-9</id>
            <name evidence="10">i</name>
            <sequence type="described" ref="VSP_058353 VSP_058357 VSP_058361"/>
        </isoform>
        <isoform>
            <id>Q95QA6-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_058357"/>
        </isoform>
        <isoform>
            <id>Q95QA6-8</id>
            <name evidence="9">h</name>
            <sequence type="described" ref="VSP_058358 VSP_058361 VSP_058353"/>
        </isoform>
        <isoform>
            <id>Q95QA6-7</id>
            <name evidence="8">g</name>
            <sequence type="described" ref="VSP_058352 VSP_058359"/>
        </isoform>
        <isoform>
            <id>Q95QA6-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_058360"/>
        </isoform>
        <isoform>
            <id>Q95QA6-10</id>
            <name evidence="11">j</name>
            <sequence type="described" ref="VSP_058355"/>
        </isoform>
        <isoform>
            <id>Q95QA6-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95QA6-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_058353 VSP_058359 VSP_058361"/>
        </isoform>
        <isoform>
            <id>Q95QA6-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_058356"/>
        </isoform>
        <isoform>
            <id>Q95QA6-11</id>
            <name evidence="12">k</name>
            <sequence type="described" ref="VSP_058354"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367551.1">
        <property type="nucleotide sequence ID" value="NM_001381700.1"/>
    </dbReference>
    <dbReference type="WormBase" id="T17H7.4c">
        <property type="protein sequence ID" value="CE28672"/>
        <property type="gene ID" value="WBGene00003936"/>
        <property type="gene designation" value="pat-12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T17H7.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T17H7.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T17H7.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T17H7.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T17H7.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T17H7.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T17H7.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T17H7.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T17H7.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T17H7.4k"/>
        </source>
    </evidence>
    <sequence length="706" mass="81659" checksum="8343EDF8D3D458D6" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QA6-4</accession>
    <name>PAT12_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of Protein pat-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Paralyzed arrest at two-fold 12 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pat-12</name>
        <name evidence="3" type="ORF">T17H7.4</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Dev. Biol." volume="350" first="267" last="278">
            <title>PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.</title>
            <authorList>
                <person name="Hetherington S."/>
                <person name="Gally C."/>
                <person name="Fritz J.A."/>
                <person name="Polanowska J."/>
                <person name="Reboul J."/>
                <person name="Schwab Y."/>
                <person name="Zahreddine H."/>
                <person name="Behm C."/>
                <person name="Labouesse M."/>
            </authorList>
            <dbReference type="PubMed" id="21130760"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.11.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH VAB-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95QA6-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_058353 VSP_058359 VSP_058361"/>
        </isoform>
        <isoform>
            <id>Q95QA6-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95QA6-10</id>
            <name evidence="11">j</name>
            <sequence type="described" ref="VSP_058355"/>
        </isoform>
        <isoform>
            <id>Q95QA6-8</id>
            <name evidence="9">h</name>
            <sequence type="described" ref="VSP_058358 VSP_058353 VSP_058361"/>
        </isoform>
        <isoform>
            <id>Q95QA6-9</id>
            <name evidence="10">i</name>
            <sequence type="described" ref="VSP_058353 VSP_058357 VSP_058361"/>
        </isoform>
        <isoform>
            <id>Q95QA6-11</id>
            <name evidence="12">k</name>
            <sequence type="described" ref="VSP_058354"/>
        </isoform>
        <isoform>
            <id>Q95QA6-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_058357"/>
        </isoform>
        <isoform>
            <id>Q95QA6-4</id>
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            <sequence type="described" ref="VSP_058356"/>
        </isoform>
        <isoform>
            <id>Q95QA6-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_058360"/>
        </isoform>
        <isoform>
            <id>Q95QA6-7</id>
            <name evidence="8">g</name>
            <sequence type="described" ref="VSP_058359 VSP_058352"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379711.1">
        <property type="nucleotide sequence ID" value="NM_001393260.1"/>
    </dbReference>
    <dbReference type="WormBase" id="T17H7.4d">
        <property type="protein sequence ID" value="CE35016"/>
        <property type="gene ID" value="WBGene00003936"/>
        <property type="gene designation" value="pat-12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T17H7.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T17H7.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T17H7.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T17H7.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T17H7.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T17H7.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T17H7.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T17H7.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T17H7.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T17H7.4k"/>
        </source>
    </evidence>
    <sequence length="1030" mass="117797" checksum="04C4F9F46F43F865" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QA6-5</accession>
    <name>PAT12_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform e of Protein pat-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Paralyzed arrest at two-fold 12 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pat-12</name>
        <name evidence="4" type="ORF">T17H7.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2011" name="Dev. Biol." volume="350" first="267" last="278">
            <title>PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.</title>
            <authorList>
                <person name="Hetherington S."/>
                <person name="Gally C."/>
                <person name="Fritz J.A."/>
                <person name="Polanowska J."/>
                <person name="Reboul J."/>
                <person name="Schwab Y."/>
                <person name="Zahreddine H."/>
                <person name="Behm C."/>
                <person name="Labouesse M."/>
            </authorList>
            <dbReference type="PubMed" id="21130760"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.11.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH VAB-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95QA6-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_058356"/>
        </isoform>
        <isoform>
            <id>Q95QA6-5</id>
            <name evidence="8">e</name>
            <sequence type="described" ref="VSP_058359 VSP_058353 VSP_058361"/>
        </isoform>
        <isoform>
            <id>Q95QA6-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_058353 VSP_058361 VSP_058358"/>
        </isoform>
        <isoform>
            <id>Q95QA6-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_058355"/>
        </isoform>
        <isoform>
            <id>Q95QA6-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_058357"/>
        </isoform>
        <isoform>
            <id>Q95QA6-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95QA6-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_058353 VSP_058357 VSP_058361"/>
        </isoform>
        <isoform>
            <id>Q95QA6-11</id>
            <name evidence="13">k</name>
            <sequence type="described" ref="VSP_058354"/>
        </isoform>
        <isoform>
            <id>Q95QA6-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_058360"/>
        </isoform>
        <isoform>
            <id>Q95QA6-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_058352 VSP_058359"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367552.1">
        <property type="nucleotide sequence ID" value="NM_001381703.2"/>
    </dbReference>
    <dbReference type="WormBase" id="T17H7.4e">
        <property type="protein sequence ID" value="CE31612"/>
        <property type="gene ID" value="WBGene00003936"/>
        <property type="gene designation" value="pat-12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="21130760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T17H7.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T17H7.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T17H7.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T17H7.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T17H7.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T17H7.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T17H7.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T17H7.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T17H7.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="T17H7.4k"/>
        </source>
    </evidence>
    <sequence length="476" mass="55508" checksum="CAB3726B05DF9C11" modified="2001-12-01" version="1">MRQGGIYQTKDANKGPVNAELDELSKRAEELRKRDGWSKYKLVESDIYKTDPDPMPANIKDQVRDLLESRNSVETTTTQRDHDKSGYVTDDKPRSIMKRNDLVRREQMLYPTVDTQVVKSVVKKPTVTETVQRFEETRRTEEVERRVQRREKKERRSRHHSSSRHHSGWEGHTGGYQEYRQGAITSSLPRRQIIREADRAMTEEEMNKVVREAYAAADEARKDSRHRSSSLSRGGHGGGGQETYYRQETTRRQQHNNYDDNFNRGIAHARYGSLSDSLRRGELQYVPNGEVRQSFYRDGSNGGQRMHKSYSTRDVFTGDGYDDRRSVSSFRRGSQQQVSPFVEFPPTLPRRGGGGDYRREEDAYFRPVSKSRSYADWDDAGRAGMGREVRRYDDDMSRLEAEFRDSLLMPMPAGNMNERDHRTEQLPGGYETFNKERHANSGRRSGRDGKPVDFNEATQEYNYKREQTLNDDRRRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QA6-7</accession>
    <name>PAT12_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform g of Protein pat-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Paralyzed arrest at two-fold 12 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pat-12</name>
        <name evidence="3" type="ORF">T17H7.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Dev. Biol." volume="350" first="267" last="278">
            <title>PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.</title>
            <authorList>
                <person name="Hetherington S."/>
                <person name="Gally C."/>
                <person name="Fritz J.A."/>
                <person name="Polanowska J."/>
                <person name="Reboul J."/>
                <person name="Schwab Y."/>
                <person name="Zahreddine H."/>
                <person name="Behm C."/>
                <person name="Labouesse M."/>
            </authorList>
            <dbReference type="PubMed" id="21130760"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.11.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH VAB-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95QA6-8</id>
            <name evidence="9">h</name>
            <sequence type="described" ref="VSP_058353 VSP_058361 VSP_058358"/>
        </isoform>
        <isoform>
            <id>Q95QA6-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_058360"/>
        </isoform>
        <isoform>
            <id>Q95QA6-7</id>
            <name evidence="8">g</name>
            <sequence type="described" ref="VSP_058352 VSP_058359"/>
        </isoform>
        <isoform>
            <id>Q95QA6-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_058356"/>
        </isoform>
        <isoform>
            <id>Q95QA6-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_058357"/>
        </isoform>
        <isoform>
            <id>Q95QA6-9</id>
            <name evidence="10">i</name>
            <sequence type="described" ref="VSP_058361 VSP_058357 VSP_058353"/>
        </isoform>
        <isoform>
            <id>Q95QA6-11</id>
            <name evidence="12">k</name>
            <sequence type="described" ref="VSP_058354"/>
        </isoform>
        <isoform>
            <id>Q95QA6-10</id>
            <name evidence="11">j</name>
            <sequence type="described" ref="VSP_058355"/>
        </isoform>
        <isoform>
            <id>Q95QA6-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_058353 VSP_058361 VSP_058359"/>
        </isoform>
        <isoform>
            <id>Q95QA6-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001359886.1">
        <property type="nucleotide sequence ID" value="NM_001373834.2"/>
    </dbReference>
    <dbReference type="WormBase" id="T17H7.4g">
        <property type="protein sequence ID" value="CE31614"/>
        <property type="gene ID" value="WBGene00003936"/>
        <property type="gene designation" value="pat-12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T17H7.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T17H7.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T17H7.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T17H7.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T17H7.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T17H7.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T17H7.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T17H7.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T17H7.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T17H7.4k"/>
        </source>
    </evidence>
    <sequence length="375" mass="43791" checksum="50A2F4F77251AF9F" modified="2001-12-01" version="1">MPANIKDQVRDLLESRNSVETTTTQRDHDKSGYVTDDKPRSIMKRNDLVRREQMLYPTVDTQVVKSVVKKPTVTETVQRFEETRRTEEVERRVQRREKKERRSRHHSSSRHHSGWEGHTGGYQGHRSSSLSRGGHGGGGQETYYRQETTRRQQHNNYDDNFNRGIAHARYGSLSDSLRRGELQYVPNGEVRQSFYRDGSNGGQRMHKSYSTRDVFTGDGYDDRRSVSSFRRGSQQQVSPFVEFPPTLPRRGGGGDYRREEDAYFRPVSKSRSYADWDDAGRAGMGREVRRYDDDMSRLEAEFRDSLLMPMPAGNMNERDHRTEQLPGGYETFNKERHANSGRRSGRDGKPVDFNEATQEYNYKREQTLNDDRRRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QA6-8</accession>
    <name>PAT12_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform h of Protein pat-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Paralyzed arrest at two-fold 12 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pat-12</name>
        <name evidence="3" type="ORF">T17H7.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Dev. Biol." volume="350" first="267" last="278">
            <title>PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.</title>
            <authorList>
                <person name="Hetherington S."/>
                <person name="Gally C."/>
                <person name="Fritz J.A."/>
                <person name="Polanowska J."/>
                <person name="Reboul J."/>
                <person name="Schwab Y."/>
                <person name="Zahreddine H."/>
                <person name="Behm C."/>
                <person name="Labouesse M."/>
            </authorList>
            <dbReference type="PubMed" id="21130760"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.11.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH VAB-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95QA6-8</id>
            <name evidence="9">h</name>
            <sequence type="described" ref="VSP_058358 VSP_058353 VSP_058361"/>
        </isoform>
        <isoform>
            <id>Q95QA6-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_058360"/>
        </isoform>
        <isoform>
            <id>Q95QA6-10</id>
            <name evidence="11">j</name>
            <sequence type="described" ref="VSP_058355"/>
        </isoform>
        <isoform>
            <id>Q95QA6-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_058356"/>
        </isoform>
        <isoform>
            <id>Q95QA6-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95QA6-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_058357"/>
        </isoform>
        <isoform>
            <id>Q95QA6-9</id>
            <name evidence="10">i</name>
            <sequence type="described" ref="VSP_058353 VSP_058357 VSP_058361"/>
        </isoform>
        <isoform>
            <id>Q95QA6-7</id>
            <name evidence="8">g</name>
            <sequence type="described" ref="VSP_058352 VSP_058359"/>
        </isoform>
        <isoform>
            <id>Q95QA6-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_058353 VSP_058361 VSP_058359"/>
        </isoform>
        <isoform>
            <id>Q95QA6-11</id>
            <name evidence="12">k</name>
            <sequence type="described" ref="VSP_058354"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367554.1">
        <property type="nucleotide sequence ID" value="NM_001381701.2"/>
    </dbReference>
    <dbReference type="WormBase" id="T17H7.4h">
        <property type="protein sequence ID" value="CE31615"/>
        <property type="gene ID" value="WBGene00003936"/>
        <property type="gene designation" value="pat-12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T17H7.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T17H7.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T17H7.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T17H7.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T17H7.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T17H7.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T17H7.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T17H7.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T17H7.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T17H7.4k"/>
        </source>
    </evidence>
    <sequence length="404" mass="47142" checksum="8A294762D8853531" modified="2001-12-01" version="1">MRQGGIYQTKDANKGPVDDKPRSIMKRNDLVRREQMLYPTVDTQVVKSVVKKPTVTETVQRFEETRRTEEVERRVQRREKKERRSRHHSSSRHHSGWEGHTGGYQEYRQGAITSSLPRRQIIREADRAMTEEEMNKVVREAYAAADEARKDSRHRSSSLSRGGHGGGGQETYYRQETTRRQQHNNYDDNFNRGIAHARYGSLSDSLRRGELQYVPNGEVRQSFYRDGSNGGQRMHKSYSTRDVFTGDGYDDRRSVSSFRRGSQQQVSPFVEFPPTLPRRGGGGDYRREEDAYFRPVSKSRSYADWDDAGRAGMGREVRRYDDDMSRLEAEFRDSLLMPMPAGNMNERDHRTEQLPGGYETFNKERHANSGRRSGRDGKPVDFNEATQEYNYKREQTLNDDRRRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QA6-9</accession>
    <name>PAT12_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform i of Protein pat-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Paralyzed arrest at two-fold 12 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pat-12</name>
        <name evidence="4" type="ORF">T17H7.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2011" name="Dev. Biol." volume="350" first="267" last="278">
            <title>PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.</title>
            <authorList>
                <person name="Hetherington S."/>
                <person name="Gally C."/>
                <person name="Fritz J.A."/>
                <person name="Polanowska J."/>
                <person name="Reboul J."/>
                <person name="Schwab Y."/>
                <person name="Zahreddine H."/>
                <person name="Behm C."/>
                <person name="Labouesse M."/>
            </authorList>
            <dbReference type="PubMed" id="21130760"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.11.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH VAB-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95QA6-11</id>
            <name evidence="13">k</name>
            <sequence type="described" ref="VSP_058354"/>
        </isoform>
        <isoform>
            <id>Q95QA6-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95QA6-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_058359 VSP_058352"/>
        </isoform>
        <isoform>
            <id>Q95QA6-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_058357 VSP_058353 VSP_058361"/>
        </isoform>
        <isoform>
            <id>Q95QA6-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_058356"/>
        </isoform>
        <isoform>
            <id>Q95QA6-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_058360"/>
        </isoform>
        <isoform>
            <id>Q95QA6-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_058357"/>
        </isoform>
        <isoform>
            <id>Q95QA6-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_058353 VSP_058361 VSP_058358"/>
        </isoform>
        <isoform>
            <id>Q95QA6-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_058355"/>
        </isoform>
        <isoform>
            <id>Q95QA6-5</id>
            <name evidence="8">e</name>
            <sequence type="described" ref="VSP_058353 VSP_058361 VSP_058359"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367555.1">
        <property type="nucleotide sequence ID" value="NM_001381702.2"/>
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        <property type="protein sequence ID" value="CE31616"/>
        <property type="gene ID" value="WBGene00003936"/>
        <property type="gene designation" value="pat-12"/>
    </dbReference>
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        <property type="component" value="Chromosome III"/>
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    <evidence type="ECO:0000269" key="1">
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            <dbReference type="PubMed" id="21130760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T17H7.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T17H7.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T17H7.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T17H7.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T17H7.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T17H7.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T17H7.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T17H7.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T17H7.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="T17H7.4k"/>
        </source>
    </evidence>
    <sequence length="447" mass="52091" checksum="FAC156E0A33A24FE" modified="2001-12-01" version="1">MRQGGIYQTKDANKGPVTVPPLRTKTPPPPPPPVRRHEIYEQHKRYTSAPNLQSAVIRIQDDKPRSIMKRNDLVRREQMLYPTVDTQVVKSVVKKPTVTETVQRFEETRRTEEVERRVQRREKKERRSRHHSSSRHHSGWEGHTGGYQEYRQGAITSSLPRRQIIREADRAMTEEEMNKVVREAYAAADEARKDSRHRSSSLSRGGHGGGGQETYYRQETTRRQQHNNYDDNFNRGIAHARYGSLSDSLRRGELQYVPNGEVRQSFYRDGSNGGQRMHKSYSTRDVFTGDGYDDRRSVSSFRRGSQQQVSPFVEFPPTLPRRGGGGDYRREEDAYFRPVSKSRSYADWDDAGRAGMGREVRRYDDDMSRLEAEFRDSLLMPMPAGNMNERDHRTEQLPGGYETFNKERHANSGRRSGRDGKPVDFNEATQEYNYKREQTLNDDRRRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-05-25" modified="2026-01-28" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q95Y41-2</accession>
    <name>RCORA_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of REST corepressor rcor-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rcor-1</name>
        <name evidence="5" type="ORF">Y74C9A.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2015" name="Nucleic Acids Res." volume="43" first="9694" last="9710">
            <title>H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Vandamme J."/>
                <person name="Sidoli S."/>
                <person name="Mariani L."/>
                <person name="Friis C."/>
                <person name="Christensen J."/>
                <person name="Helin K."/>
                <person name="Jensen O.N."/>
                <person name="Salcini A.E."/>
            </authorList>
            <dbReference type="PubMed" id="26476455"/>
            <dbReference type="DOI" id="10.1093/nar/gkv1063"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HPL-1</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95Y41-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_061504"/>
        </isoform>
        <isoform>
            <id>Q95Y41-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_061503"/>
        </isoform>
        <isoform>
            <id>Q95Y41-1</id>
            <name evidence="5">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95Y41-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_061505"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_490663.1">
        <property type="nucleotide sequence ID" value="NM_058262.7"/>
    </dbReference>
    <dbReference type="WormBase" id="Y74C9A.4a">
        <property type="protein sequence ID" value="CE24662"/>
        <property type="gene ID" value="WBGene00022278"/>
        <property type="gene designation" value="rcor-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="26476455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y74C9A.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y74C9A.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y74C9A.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y74C9A.4d"/>
        </source>
    </evidence>
    <sequence length="561" mass="65604" checksum="2132CB794E017479" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-05-25" modified="2026-01-28" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q95Y41-3</accession>
    <name>RCORA_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of REST corepressor rcor-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rcor-1</name>
        <name evidence="5" type="ORF">Y74C9A.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2015" name="Nucleic Acids Res." volume="43" first="9694" last="9710">
            <title>H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Vandamme J."/>
                <person name="Sidoli S."/>
                <person name="Mariani L."/>
                <person name="Friis C."/>
                <person name="Christensen J."/>
                <person name="Helin K."/>
                <person name="Jensen O.N."/>
                <person name="Salcini A.E."/>
            </authorList>
            <dbReference type="PubMed" id="26476455"/>
            <dbReference type="DOI" id="10.1093/nar/gkv1063"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HPL-1</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95Y41-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_061503"/>
        </isoform>
        <isoform>
            <id>Q95Y41-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_061504"/>
        </isoform>
        <isoform>
            <id>Q95Y41-1</id>
            <name evidence="5">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95Y41-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_061505"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001293207.1">
        <property type="nucleotide sequence ID" value="NM_001306278.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y74C9A.4c">
        <property type="protein sequence ID" value="CE49153"/>
        <property type="gene ID" value="WBGene00022278"/>
        <property type="gene designation" value="rcor-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="26476455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y74C9A.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y74C9A.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y74C9A.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y74C9A.4d"/>
        </source>
    </evidence>
    <sequence length="533" mass="62534" checksum="DD7579AD6003F07E" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-05-25" modified="2026-01-28" version="174" xmlns="https://uniprot.org/uniprot">
    <accession>Q95Y41-4</accession>
    <name>RCORA_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of REST corepressor rcor-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rcor-1</name>
        <name evidence="5" type="ORF">Y74C9A.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2015" name="Nucleic Acids Res." volume="43" first="9694" last="9710">
            <title>H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Vandamme J."/>
                <person name="Sidoli S."/>
                <person name="Mariani L."/>
                <person name="Friis C."/>
                <person name="Christensen J."/>
                <person name="Helin K."/>
                <person name="Jensen O.N."/>
                <person name="Salcini A.E."/>
            </authorList>
            <dbReference type="PubMed" id="26476455"/>
            <dbReference type="DOI" id="10.1093/nar/gkv1063"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HPL-1</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95Y41-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_061505"/>
        </isoform>
        <isoform>
            <id>Q95Y41-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_061504"/>
        </isoform>
        <isoform>
            <id>Q95Y41-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_061503"/>
        </isoform>
        <isoform>
            <id>Q95Y41-1</id>
            <name evidence="5">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001293208.1">
        <property type="nucleotide sequence ID" value="NM_001306279.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y74C9A.4d">
        <property type="protein sequence ID" value="CE49439"/>
        <property type="gene ID" value="WBGene00022278"/>
        <property type="gene designation" value="rcor-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="26476455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y74C9A.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y74C9A.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y74C9A.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y74C9A.4d"/>
        </source>
    </evidence>
    <sequence length="274" mass="32222" checksum="4E5677B414145DCF" modified="2001-12-01" version="1">MSRHECKPCILYFRLMRVPRPASLRALTKRRQRVLCPEYMKIYVYGYLELMEPANGKAIKRLGIGKEKEEDDDIMVVDDCLLRKPSGPYIVEQSIEADPIDENTCRMTRCFDTPAALALIDNIKRKHHMCVPLVWRVKQTKCMEENEILNEEARQQMFRATMTYSRVPKGEIANWKKDMMALKGRFERFTPELDTTATNGNRSGKVRINYGWSPEEKKNAIRCFHWYKDNFELIAELMATKTVEQIKKFYMDNEKLILESIDTYRAELKSKLGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="183" xmlns="https://uniprot.org/uniprot">
    <accession>Q9GN62-2</accession>
    <name>PAR4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Isoform b of Serine/threonine-protein kinase par-4</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">par-4</name>
        <name type="ORF">Y59A8B.14</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1988" name="Cell" volume="52" first="311" last="320">
            <title>Identification of genes required for cytoplasmic localization in early C. elegans embryos.</title>
            <authorList>
                <person name="Kemphues K.J."/>
                <person name="Priess J.R."/>
                <person name="Morton D.G."/>
                <person name="Cheng N.S."/>
            </authorList>
            <dbReference type="PubMed" id="3345562"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(88)80024-2"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2000" name="Development" volume="127" first="1467" last="1475">
            <title>The Caenorhabditis elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry.</title>
            <authorList>
                <person name="Watts J.L."/>
                <person name="Morton D.G."/>
                <person name="Bestman J."/>
                <person name="Kemphues K.J."/>
            </authorList>
            <dbReference type="PubMed" id="10704392"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2004" name="Genes Dev." volume="18" first="3004" last="3009">
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        <citation type="journal article" date="2010" name="Development" volume="137" first="661" last="670">
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        <citation type="journal article" date="2013" name="Genetics" volume="193" first="897" last="909">
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <citation type="journal article" date="2004" name="Genes Dev." volume="18" first="3004" last="3009">
            <title>The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.</title>
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            <title>The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior.</title>
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            <title>Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisions.</title>
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    <dbReference type="PANTHER" id="PTHR31063:SF3">
        <property type="entry name" value="ENHANCER OF POLYCOMB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31063">
        <property type="entry name" value="PROTEIN CBG08668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="IBR" evidence="6">
        <location>
            <begin position="541"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD62678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F26F12.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N2N2"/>
        </source>
    </evidence>
    <sequence length="805" mass="90984" checksum="B1EA251FB4A31066" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N2S1</accession>
    <name>Q9N2S1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="14">1.8.5.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Sulfide quinone oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CELE_Y9C9A.16</name>
        <name evidence="17 19" type="ORF">Y9C9A.16</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol</text>
            <dbReference type="Rhea" id="RHEA:55156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.8.5.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:55157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10</text>
            <dbReference type="Rhea" id="RHEA:62608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:62609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate</text>
            <dbReference type="Rhea" id="RHEA:38359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:38360"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SQRD family.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.8" evidence="14"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD68699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_500688.2">
        <property type="nucleotide sequence ID" value="NM_068287.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N2S1"/>
    <dbReference type="SMR" id="Q9N2S1"/>
    <dbReference type="PeptideAtlas" id="Q9N2S1"/>
    <dbReference type="GeneID" id="189421"/>
    <dbReference type="UCSC" id="Y9C9A.16">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021183"/>
    <dbReference type="CTD" id="189421"/>
    <dbReference type="WormBase" id="Y9C9A.16a">
        <property type="protein sequence ID" value="CE39879"/>
        <property type="gene ID" value="WBGene00021183"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030742_2_1_1"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021183">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N2S1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106436">
        <property type="term" value="F:glutathione-dependent sulfide quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCD68699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="Y9C9A.16a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N2S1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40578" checksum="B2637C60F46F6C43" modified="2012-01-25" version="2">MTLDSNRKKQVNLIPKGATWIQDKVETFNPSQNTVVLRGGEEISYEYMVIAMGIHLRFDMIKGAVEALETPGVCSNYSPFHVQKHYQEVMNFQKGNAIYTFPNTPIKCAGAPQKACYITDSILRQRGVRDKAHMIYATSLSKIFGVDHYVKALEKVAQEKTIEVKTKRNLIEVVTNNKKAIFELLGDDSKPTGVTEEIEFSLLHISPPCTAPEPLRSSHFADKTGFMDVDPQTLQSKNYPNVFGVGDCMNTPNAKTAASVSTHLKTVDTNLTQVMQGARPFMKYDGYASCPLVVSTNRVILAEFSPNEILETTPLNQSKPSYWAFLMKRYILPVLYWKGLIKGHWNGPSTIRNFSRLLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N302</accession>
    <name>Q9N302_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">acs-13</name>
        <name evidence="15" type="ORF">CELE_Y65B4BL.5</name>
        <name evidence="17" type="ORF">Y65B4BL.5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
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            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
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            <dbReference type="ChEBI" id="CHEBI:7896"/>
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        <property type="component" value="Chromosome I"/>
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        <property type="expression patterns" value="baseline and differential"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2 13 15" id="KW-0436">Ligase</keyword>
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    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="141"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD73491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="Y65B4BL.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N302"/>
        </source>
    </evidence>
    <sequence length="719" mass="79016" checksum="8B292D09EEDDF6FA" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="173" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XU42-2</accession>
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        <recommendedName>
            <fullName evidence="2">Isoform b of Receptor-type guanylate cyclase gcy-27</fullName>
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    <gene>
        <name evidence="4" type="primary">gcy-27</name>
        <name evidence="4" type="ORF">C06A12.4</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2006" name="Genetics" volume="173" first="131" last="149">
            <title>Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases.</title>
            <authorList>
                <person name="Ortiz C.O."/>
                <person name="Etchberger J.F."/>
                <person name="Posy S.L."/>
                <person name="Frokjaer-Jensen C."/>
                <person name="Lockery S."/>
                <person name="Honig B."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="16547101"/>
            <dbReference type="DOI" id="10.1534/genetics.106.055749"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003619" last="E1003619">
            <title>The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity.</title>
            <authorList>
                <person name="Krzyzanowski M.C."/>
                <person name="Brueggemann C."/>
                <person name="Ezak M.J."/>
                <person name="Wood J.F."/>
                <person name="Michaels K.L."/>
                <person name="Jackson C.A."/>
                <person name="Juang B.T."/>
                <person name="Collins K.D."/>
                <person name="Yu M.C."/>
                <person name="L'etoile N.D."/>
                <person name="Ferkey D.M."/>
            </authorList>
            <dbReference type="PubMed" id="23874221"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003619"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide.</title>
            <authorList>
                <person name="Hao Y."/>
                <person name="Yang W."/>
                <person name="Ren J."/>
                <person name="Hall Q."/>
                <person name="Zhang Y."/>
                <person name="Kaplan J.M."/>
            </authorList>
            <dbReference type="PubMed" id="30014846"/>
            <dbReference type="DOI" id="10.7554/eLife.36833"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9XU42-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9XU42-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_057709"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q19187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C06A12.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C06A12.4b"/>
        </source>
    </evidence>
    <sequence length="718" mass="82976" checksum="3B4DA933265FA01B" modified="2007-09-11" version="4" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-05-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCM1-2</accession>
    <name>WDR33_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of pre-mRNA 3' end processing protein pfs-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polyadenylation factor subunit homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">pfs-2</name>
        <name evidence="3" type="ORF">R06A4.9</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Development" volume="137" first="2237" last="2250">
            <title>Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans.</title>
            <authorList>
                <person name="Van Epps H."/>
                <person name="Dai Y."/>
                <person name="Qi Y."/>
                <person name="Goncharov A."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="20530551"/>
            <dbReference type="DOI" id="10.1242/dev.049692"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-147</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>U4PCM1-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_060922"/>
        </isoform>
        <isoform>
            <id>U4PCM1-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_060923 VSP_060924"/>
        </isoform>
        <isoform>
            <id>U4PCM1-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001368351.1">
        <property type="nucleotide sequence ID" value="NM_001381653.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="CE48640"/>
        <property type="gene ID" value="WBGene00011051"/>
        <property type="gene designation" value="pfs-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="20530551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93484.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="R06A4.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="R06A4.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="R06A4.9c"/>
        </source>
    </evidence>
    <sequence length="604" mass="66507" checksum="F467D96379C4C380" modified="2021-04-07" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-05-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>U4PCM1-3</accession>
    <name>WDR33_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform c of pre-mRNA 3' end processing protein pfs-2</fullName>
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        <alternativeName>
            <fullName evidence="1">Polyadenylation factor subunit homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">pfs-2</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Development" volume="137" first="2237" last="2250">
            <title>Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans.</title>
            <authorList>
                <person name="Van Epps H."/>
                <person name="Dai Y."/>
                <person name="Qi Y."/>
                <person name="Goncharov A."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="20530551"/>
            <dbReference type="DOI" id="10.1242/dev.049692"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ARG-147</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>U4PCM1-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>U4PCM1-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_060923 VSP_060924"/>
        </isoform>
        <isoform>
            <id>U4PCM1-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_060922"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379014.1">
        <property type="nucleotide sequence ID" value="NM_001393232.1"/>
    </dbReference>
    <dbReference type="WormBase" id="R06A4.9c">
        <property type="protein sequence ID" value="CE53932"/>
        <property type="gene ID" value="WBGene00011051"/>
        <property type="gene designation" value="pfs-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="20530551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="CDH93484.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="R06A4.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="R06A4.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="R06A4.9c"/>
        </source>
    </evidence>
    <sequence length="219" mass="25476" checksum="D69E6A1EBBECA67D" modified="2021-04-07" version="2">MNGGMMRGNQMPNVTLTIQPSTSSMQNSQPRIMNNHHHPHNRFQREHVMPDVMGDGPGRRLRKNVANVRRHVDYVSTVLNHCENRLWQYGKQRILQQPDILYQQYAVPADSTPDVPVDCILTKFIRTAMNKVKCPVYSVCWSPEGKRLITGCQTGEFTLWNGTAFNFETILQVKHTTRWITILYIMFTFLCSTNKVFTSFLMRHFAVFDVNKRFSFGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>U4PE16</accession>
    <name>U4PE16_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">ctl-3</name>
        <name evidence="15" type="ORF">CELE_Y54G11A.13</name>
        <name evidence="17" type="ORF">Y54G11A.13</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH92994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293540.1">
        <property type="nucleotide sequence ID" value="NM_001306611.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PE16"/>
    <dbReference type="SMR" id="U4PE16"/>
    <dbReference type="PeptideAtlas" id="U4PE16"/>
    <dbReference type="GeneID" id="175086"/>
    <dbReference type="KEGG" id="cel:CELE_Y54G11A.13"/>
    <dbReference type="AGR" id="WB:WBGene00013220"/>
    <dbReference type="CTD" id="175086"/>
    <dbReference type="WormBase" id="Y54G11A.13b">
        <property type="protein sequence ID" value="CE48795"/>
        <property type="gene ID" value="WBGene00013220"/>
        <property type="gene designation" value="ctl-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013220">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PE16">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="20"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDH92994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="Y54G11A.13b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="U4PE16"/>
        </source>
    </evidence>
    <sequence length="493" mass="56925" checksum="89E451425DCD9BED" modified="2013-12-11" version="1">MAEDQLKAYRDRNQEPHLLTTSNGAPIYSKTAVLTAGRRGPMLMQDIVYMDEMAHFDRERIPERVVHAKGGGAHGYFEVTHDITKYCKADMFNKVGKQTPLLVRFSTVAGESGSADTVRDPRGFSLKFYTEEGNWDLVGNNTPIFFIRDAIHFPNFIHALKRNPQTHMRDPNALFDFWMNRPESIHQVMFLYSDRGIPDGFRFMNGYGAHTFKMVNKEGNPIYCKFHFKPAQGSKNLDPTDAGKLASSDPDYAIRDLFNAIESRNFPEWKMFIQVMTFEQAEKWEFNPFDVTKVWPHGDYPLIEVGKMVLNRNVKNYFAEVEQAAFCPAHIVPGIEFSPDKMLQGRIFSYTDTHYHRLGPNYIQLPVNCPYRSRAHTTQRDGAMAYESQGDAPNYFPNSFRGYRTRDDVKESTFQTTGDVDRYETGDDHNYEQPRQFWEKVLKEEERDRLVGNLASDLGGCLEEIQNGMVKEFTKVHPDFGNALRHQLCQKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BQH9</accession>
    <name>A0A078BQH9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y71F9B.6</name>
        <name evidence="3 5" type="ORF">Y71F9B.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293370.1">
        <property type="nucleotide sequence ID" value="NM_001306441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BQH9"/>
    <dbReference type="SMR" id="A0A078BQH9"/>
    <dbReference type="GeneID" id="260184"/>
    <dbReference type="AGR" id="WB:WBGene00022128"/>
    <dbReference type="CTD" id="260184"/>
    <dbReference type="WormBase" id="Y71F9B.6d">
        <property type="protein sequence ID" value="CE50077"/>
        <property type="gene ID" value="WBGene00022128"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5353095at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022128">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BQH9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20556">
        <property type="entry name" value="CYCLIN_CABLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012388">
        <property type="entry name" value="CABLES1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896">
        <property type="entry name" value="CDK5 AND ABL1 ENZYME SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896:SF0">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="109"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y71F9B.6d"/>
        </source>
    </evidence>
    <sequence length="217" mass="24563" checksum="1176CBB39ABB2252" modified="2014-10-29" version="1">MFAETIEVPQAVNRDSSYERGTSIDEKCDLDASRSDEPSSEVIDEYDPIAFSELGIGKRTVIRHECCVASTLHCESAERAKQVINEDFEAKYPMIHLTLSKMKSLKREMAELGVSNGIDVYTVATAYVYFEKIILKGLISKVNRKCVAGAALLVALKMNDYKKSTIKSYIEQAEDQLREPKSDLLAYELPICSVLQFRLQPTIDEIQPHVDRLQFEM</sequence>
</entry>
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    <accession>A0A078BQI3</accession>
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        <name type="scientific">Caenorhabditis elegans</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
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    <dbReference type="WormBase" id="Y71F9B.10e">
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        <property type="gene ID" value="WBGene00004946"/>
        <property type="gene designation" value="sop-3"/>
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    </dbReference>
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="598"/>
            <end position="1165"/>
        </location>
    </feature>
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        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="559"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="605"/>
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            <end position="642"/>
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    </feature>
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        </location>
    </feature>
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            <begin position="998"/>
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        </location>
    </feature>
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        <location>
            <begin position="1010"/>
            <end position="1024"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDX47424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="Y71F9B.10e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BQI3"/>
        </source>
    </evidence>
    <sequence length="1165" mass="129292" checksum="BC5FC23F58BBD152" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BQJ2</accession>
    <name>A0A078BQJ2_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">DUF3456 domain-containing protein</fullName>
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    </gene>
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    <reference evidence="4 5" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cel:CELE_C11H1.7"/>
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        <property type="gene ID" value="WBGene00007531"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDX47439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C11H1.7b"/>
        </source>
    </evidence>
    <sequence length="71" mass="8452" checksum="30AD363D25872EBD" modified="2014-10-29" version="1">MPFEMWDQPSAEIFALRQGCESLLEDYEDLIEEWFINKASLEDLFKQLCARNALKNQETSCFDHLDHKQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BQJ7</accession>
    <name>A0A078BQJ7_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">TSC22 domain family protein 1-like</fullName>
        </submittedName>
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        <name evidence="3 5" type="ORF">C30G4.4</name>
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    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0006357">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDX47444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C30G4.4f"/>
        </source>
    </evidence>
    <sequence length="309" mass="33890" checksum="59DBAD8D23D2CE60" modified="2014-10-29" version="1">MAALFNESLRKVNEQQPPTIIEEDETPKRANRPPDLQGFSILDEKWRSSCSDDSDDSLPVGSYISTAEKPLRFCKSVDFRPLRREAPNLTGDSCSTLPSTPVHKKNPPLPTMSSGGSRFKVVPVETRDPYFSPNGKHAIAKPTAAIKNIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKSVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BQK0</accession>
    <name>A0A078BQK0_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">TSC22 domain family protein 1-like</fullName>
        </submittedName>
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        <name evidence="3 5" type="ORF">C30G4.4</name>
        <name evidence="3" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001307882.3"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A078BQK0"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4k">
        <property type="protein sequence ID" value="CE50008"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BQK0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C30G4.4k"/>
        </source>
    </evidence>
    <sequence length="246" mass="27005" checksum="22FB29F5260AC56A" modified="2014-10-29" version="1">MSSGGSRFKQSESPINMLITHREMKCDMKSEPSLKVVPVETRDPYFSPNGKHAIAKPTAAIKKEEIVNRSSRSLSDIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKRAPLVRAKTVVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BQK4</accession>
    <name>A0A078BQK4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TSC22 domain family protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C30G4.4</name>
        <name evidence="3" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294816.1">
        <property type="nucleotide sequence ID" value="NM_001307887.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BQK4"/>
    <dbReference type="SMR" id="A0A078BQK4"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4p">
        <property type="protein sequence ID" value="CE50023"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BQK4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C30G4.4p"/>
        </source>
    </evidence>
    <sequence length="211" mass="22984" checksum="14FB5601C39158A7" modified="2014-10-29" version="1">MSSGGSRFKVVPVETRDPYFSPNGKHAIAKPTAAIKKEEIVNRSSRSLSDIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKSVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1E507</accession>
    <name>A0A3B1E507_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">try-10</name>
        <name evidence="4" type="ORF">CELE_F15B9.5</name>
        <name evidence="6" type="ORF">F15B9.5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="VAY52522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355438.1">
        <property type="nucleotide sequence ID" value="NM_001368472.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1E507"/>
    <dbReference type="SMR" id="A0A3B1E507"/>
    <dbReference type="IntAct" id="A0A3B1E507">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="179787"/>
    <dbReference type="AGR" id="WB:WBGene00008849"/>
    <dbReference type="CTD" id="179787"/>
    <dbReference type="WormBase" id="F15B9.5d">
        <property type="protein sequence ID" value="CE41118"/>
        <property type="gene ID" value="WBGene00008849"/>
        <property type="gene designation" value="try-10"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5790020at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008849">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1E507">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017485381" evidence="2">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VAY52522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F15B9.5d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A3B1E507"/>
        </source>
    </evidence>
    <sequence length="297" mass="32593" checksum="6E9B0DD7B9C65D0E" modified="2018-12-05" version="1">MNFFILLLSFISYSTSIINGFSANSFDTLSLASVITRFPDGTTNVCGGVLIAPSIVITSAHCVFSGDDFAVTAKVTLGDVHLNKHDDGEQEFRSHAMAISKKFFNDASEANDDVAVIFLPQRADVCHSPLSLQIAKLPSTGSVNFKETAPLTQLQLETSVCYVAGWGKTENKTAKYSDSVRQMMVNLSVRRIGKRKYLIAKAVTGSSRACMGDSGSPVYCFVNGKRILVGTVAHIGSFSKMSEQDPSNHISFCRDFEYTFVSDWRESSERVVEILQKYGELYQLNEGQNMCFGSGIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A486WWJ9-2</accession>
    <name>SOMI1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Zinc finger protein somi-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Suppressor of overexpressed micro-RNA protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">somi-1</name>
        <name evidence="5" type="ORF">M04G12.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Genes Dev." volume="25" first="2079" last="2092">
            <title>The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.</title>
            <authorList>
                <person name="Hayes G.D."/>
                <person name="Riedel C.G."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="21979920"/>
            <dbReference type="DOI" id="10.1101/gad.17153811"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SWSN-9</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 44-GLN--LEU-582; 175-GLN--VAL-582 AND 333-ARG--VAL-582</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A486WWJ9-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060871"/>
        </isoform>
        <isoform>
            <id>A0A486WWJ9-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060872"/>
        </isoform>
        <isoform>
            <id>A0A486WWJ9-1</id>
            <name evidence="5">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A486WWJ9-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060871 VSP_060872"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_506320.3">
        <property type="nucleotide sequence ID" value="NM_073919.5"/>
    </dbReference>
    <dbReference type="WormBase" id="M04G12.4a">
        <property type="protein sequence ID" value="CE36495"/>
        <property type="gene ID" value="WBGene00010868"/>
        <property type="gene designation" value="somi-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="M04G12.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="M04G12.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="M04G12.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="M04G12.4d"/>
        </source>
    </evidence>
    <sequence length="579" mass="63207" checksum="106720325243F92D" modified="2019-06-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A486WWJ9-3</accession>
    <name>SOMI1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Zinc finger protein somi-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Suppressor of overexpressed micro-RNA protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">somi-1</name>
        <name evidence="5" type="ORF">M04G12.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Genes Dev." volume="25" first="2079" last="2092">
            <title>The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.</title>
            <authorList>
                <person name="Hayes G.D."/>
                <person name="Riedel C.G."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="21979920"/>
            <dbReference type="DOI" id="10.1101/gad.17153811"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SWSN-9</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 44-GLN--LEU-582; 175-GLN--VAL-582 AND 333-ARG--VAL-582</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A486WWJ9-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060872 VSP_060871"/>
        </isoform>
        <isoform>
            <id>A0A486WWJ9-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060871"/>
        </isoform>
        <isoform>
            <id>A0A486WWJ9-1</id>
            <name evidence="5">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A486WWJ9-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060872"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379322.1">
        <property type="nucleotide sequence ID" value="NM_001392639.1"/>
    </dbReference>
    <dbReference type="WormBase" id="M04G12.4b">
        <property type="protein sequence ID" value="CE36496"/>
        <property type="gene ID" value="WBGene00010868"/>
        <property type="gene designation" value="somi-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="M04G12.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="M04G12.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="M04G12.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="M04G12.4d"/>
        </source>
    </evidence>
    <sequence length="550" mass="60015" checksum="9A9B18AFD2E002F2" modified="2019-06-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A486WWJ9-4</accession>
    <name>SOMI1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of Zinc finger protein somi-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Suppressor of overexpressed micro-RNA protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">somi-1</name>
        <name evidence="5" type="ORF">M04G12.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Genes Dev." volume="25" first="2079" last="2092">
            <title>The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.</title>
            <authorList>
                <person name="Hayes G.D."/>
                <person name="Riedel C.G."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="21979920"/>
            <dbReference type="DOI" id="10.1101/gad.17153811"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SWSN-9</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 44-GLN--LEU-582; 175-GLN--VAL-582 AND 333-ARG--VAL-582</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A486WWJ9-1</id>
            <name evidence="5">c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A486WWJ9-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060871"/>
        </isoform>
        <isoform>
            <id>A0A486WWJ9-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060872 VSP_060871"/>
        </isoform>
        <isoform>
            <id>A0A486WWJ9-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060872"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001360558.1">
        <property type="nucleotide sequence ID" value="NM_001373145.2"/>
    </dbReference>
    <dbReference type="WormBase" id="M04G12.4d">
        <property type="protein sequence ID" value="CE53125"/>
        <property type="gene ID" value="WBGene00010868"/>
        <property type="gene designation" value="somi-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="M04G12.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="M04G12.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="M04G12.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="M04G12.4d"/>
        </source>
    </evidence>
    <sequence length="553" mass="60344" checksum="59FEAA303C310C82" modified="2019-06-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D7ZEM6</accession>
    <name>A0A8D7ZEM6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">natc-3</name>
        <name evidence="2" type="ORF">CELE_Y48G1C.9</name>
        <name evidence="4" type="ORF">Y48G1C.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAG4685887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001382272.1">
        <property type="nucleotide sequence ID" value="NM_001395347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D7ZEM6"/>
    <dbReference type="GeneID" id="3565103"/>
    <dbReference type="AGR" id="WB:WBGene00021682"/>
    <dbReference type="CTD" id="3565103"/>
    <dbReference type="WormBase" id="Y48G1C.9b">
        <property type="protein sequence ID" value="CE54323"/>
        <property type="gene ID" value="WBGene00021682"/>
        <property type="gene designation" value="natc-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG4685887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y48G1C.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8D7ZEM6"/>
        </source>
    </evidence>
    <sequence length="21" mass="2421" checksum="13E74CF35EEC0962" modified="2022-01-19" version="1">MISKKHVESMHALPDPKETEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D7ZEM7</accession>
    <name>A0A8D7ZEM7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ligand-Gated ion Channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">lgc-56</name>
        <name evidence="14" type="ORF">CELE_F09C12.1</name>
        <name evidence="16" type="ORF">F09C12.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAG4685888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001408257.1">
        <property type="nucleotide sequence ID" value="NM_001421347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D7ZEM7"/>
    <dbReference type="SMR" id="A0A8D7ZEM7"/>
    <dbReference type="GeneID" id="191638"/>
    <dbReference type="KEGG" id="cel:CELE_F09C12.1"/>
    <dbReference type="AGR" id="WB:WBGene00001588"/>
    <dbReference type="CTD" id="191638"/>
    <dbReference type="WormBase" id="F09C12.1b">
        <property type="protein sequence ID" value="CE54319"/>
        <property type="gene ID" value="WBGene00001588"/>
        <property type="gene designation" value="lgc-56"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000039">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000034">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="37"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="250"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG4685888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="F09C12.1b"/>
        </source>
    </evidence>
    <sequence length="438" mass="50685" checksum="DC3197E818169F69" modified="2022-01-19" version="1">MLHDVIYMLLISTVAKEVKTESLVDPAHCEYNSNHRKSILTDLLQDYDKTMVPSNNSVQVSVELTVQDISSISEISSSFIADVWFSQVWYDPRLEYRNISCKTNLSLDSYVSERLWTPNVCFVNSKSTQVHKSPASNILLIIYPNGTVWLNYRVQVSAPCSFELSRFPIDAQECHLVFESYSYNIAEVRLNWQQWAPVTMPPPEDFRLPDFQFYNVTWGKTSNEYTAGMWDQLKVTFRFKRLYGYYVLQMYLPTYLSVFISWIAFWIDTRALPARITLGVSSLMALTFQFGNIVKNLPRVSFVKAIDLWFFVCVAFIFFSLVELAVVGFVDKITEIKRRSRRIKFQRAIAGGTIKKKYSCTSKCNSVRYNINNNDDEELYNISGETNGNGVSWKNNSSREASADMGARVDSFAAKAFPAMFAAFNVFYWWYYLSRERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A9D7B8</accession>
    <name>A9D7B8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 28 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_K04F10.3</name>
        <name evidence="2 4" type="ORF">K04F10.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD70046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122491.1">
        <property type="nucleotide sequence ID" value="NM_001129019.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9D7B8"/>
    <dbReference type="SMR" id="A9D7B8"/>
    <dbReference type="PeptideAtlas" id="A9D7B8"/>
    <dbReference type="GeneID" id="172334"/>
    <dbReference type="UCSC" id="K04F10.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019396"/>
    <dbReference type="CTD" id="172334"/>
    <dbReference type="WormBase" id="K04F10.3b">
        <property type="protein sequence ID" value="CE42009"/>
        <property type="gene ID" value="WBGene00019396"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073175_0_0_1"/>
    <dbReference type="OrthoDB" id="5804051at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019396">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A9D7B8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD70046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K04F10.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A9D7B8"/>
        </source>
    </evidence>
    <sequence length="260" mass="29828" checksum="88691077635F7FF6" modified="2008-02-05" version="1">MSDDESIFVPDENSAQVSAETTVKWTDSASSQKVINNLEKFVLNQSLDKSYKKIASDGIASSKRTLESLLARNGGHQNLLNEEVNKLNNKNYTLDADGRVCLVKNSSNDTSRHQELILLQKDTHELRCLREYLMLALEAIMHNHRQMMVKHVQNVRERPRQVSQAAIDNAIEKANTRIIDEFAQMTLFVDQSIAREEIRSENRRKLKKTIEIETFLMRMMLEMEDIREANVKDLVSLWRSHQRSAKTQPTNNNAAGDSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRG1</accession>
    <name>C6KRG1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pharyngeal MARGginal cell marker</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">marg-1</name>
        <name evidence="2" type="ORF">CELE_F47B7.7</name>
        <name evidence="4" type="ORF">F47B7.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD70499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257005.1">
        <property type="nucleotide sequence ID" value="NM_001270076.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRG1"/>
    <dbReference type="PeptideAtlas" id="C6KRG1"/>
    <dbReference type="GeneID" id="180665"/>
    <dbReference type="AGR" id="WB:WBGene00018538"/>
    <dbReference type="CTD" id="180665"/>
    <dbReference type="WormBase" id="F47B7.7b">
        <property type="protein sequence ID" value="CE43827"/>
        <property type="gene ID" value="WBGene00018538"/>
        <property type="gene designation" value="marg-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1262548_0_0_1"/>
    <dbReference type="OrthoDB" id="5781026at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018538">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRG1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD70499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F47B7.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="C6KRG1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24872" checksum="ABF2C7C765238916" modified="2009-09-01" version="1">MAPPTTIPNLFMSDFGLNTDDIKYFHMDSHIQGRGPNRLKHLDIEGRWVLSGKSIPFISAAFNHLERLNDAQVPLRDITEEPIDAIGMVGWTKSSAPAEEAPKEEKKIPKKFVLQPPVFVEDEVPPSPREVVPHRSAGYGPAHHKRKLSIPDRSRSVSPMPAEAPGQTVFDKYAKYERHRKDSITRYGTKWGDAGYVSHSPSPTGEIHEEYQYTRQYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRH8</accession>
    <name>C6KRH8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTPase-activating protein rrc-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">RhoGAP for Rac-1 and Cdc-42</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">rrc-1</name>
        <name evidence="9" type="ORF">CELE_F47A4.3</name>
        <name evidence="11" type="ORF">F47A4.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAZ65502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257090.1">
        <property type="nucleotide sequence ID" value="NM_001270161.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRH8"/>
    <dbReference type="SMR" id="C6KRH8"/>
    <dbReference type="PeptideAtlas" id="C6KRH8"/>
    <dbReference type="GeneID" id="181195"/>
    <dbReference type="AGR" id="WB:WBGene00009800"/>
    <dbReference type="CTD" id="181195"/>
    <dbReference type="WormBase" id="F47A4.3c">
        <property type="protein sequence ID" value="CE43859"/>
        <property type="gene ID" value="WBGene00009800"/>
        <property type="gene designation" value="rrc-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021271_0_0_1"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009800">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRH8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000140">
        <property type="entry name" value="GTPase-activating protein rrc-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000346">
        <property type="entry name" value="GTPase-activating protein rrc-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051576">
        <property type="entry name" value="PX-Rho_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF10">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN CDGAPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="164"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="280"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAZ65502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F47A4.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="C6KRH8"/>
        </source>
    </evidence>
    <sequence length="758" mass="86933" checksum="E5D2A5487FE54453" modified="2009-09-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D9N119</accession>
    <name>D9N119_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4316 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F26G1.2</name>
        <name evidence="2 4" type="ORF">F26G1.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD65855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040769.2">
        <property type="nucleotide sequence ID" value="NM_001047304.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N119"/>
    <dbReference type="PeptideAtlas" id="D9N119"/>
    <dbReference type="GeneID" id="184993"/>
    <dbReference type="AGR" id="WB:WBGene00017838"/>
    <dbReference type="CTD" id="184993"/>
    <dbReference type="WormBase" id="F26G1.2b">
        <property type="protein sequence ID" value="CE44910"/>
        <property type="gene ID" value="WBGene00017838"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5821797at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017838">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N119">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38608">
        <property type="entry name" value="PROTEIN CBG07207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38608:SF2">
        <property type="entry name" value="SIGNAL PEPTIDE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F26G1.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="D9N119"/>
        </source>
    </evidence>
    <sequence length="118" mass="12845" checksum="E3A41A6186A91C43" modified="2010-10-05" version="1">MLGMMNSPSDSVEFYATNRKVSDELGSAAENSEELKKFSEVKQKDVVSYTEDGRKMINGKLVNESDAPTMWGSALLRGRIRTITGAPLTDKEKKEESNAPQPVEITPVAVVGSDSPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>D9N131</accession>
    <name>D9N131_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">kvs-2</name>
        <name evidence="17" type="ORF">C32C4.1</name>
        <name evidence="15" type="ORF">CELE_C32C4.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO22678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256237.1">
        <property type="nucleotide sequence ID" value="NM_001269308.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N131"/>
    <dbReference type="SMR" id="D9N131"/>
    <dbReference type="GeneID" id="183120"/>
    <dbReference type="AGR" id="WB:WBGene00007862"/>
    <dbReference type="CTD" id="183120"/>
    <dbReference type="WormBase" id="C32C4.1e">
        <property type="protein sequence ID" value="CE45141"/>
        <property type="gene ID" value="WBGene00007862"/>
        <property type="gene designation" value="kvs-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007862">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N131">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000088">
        <property type="entry name" value="Protein CBG09661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000176">
        <property type="entry name" value="Protein CBG09661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF121">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="57"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBO22678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C32C4.1e"/>
        </source>
    </evidence>
    <sequence length="523" mass="59602" checksum="1A9EC636E7A7B3B5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>D9N132</accession>
    <name>D9N132_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">kvs-2</name>
        <name evidence="17" type="ORF">C32C4.1</name>
        <name evidence="15" type="ORF">CELE_C32C4.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO22679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256235.1">
        <property type="nucleotide sequence ID" value="NM_001269306.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N132"/>
    <dbReference type="SMR" id="D9N132"/>
    <dbReference type="GeneID" id="183120"/>
    <dbReference type="AGR" id="WB:WBGene00007862"/>
    <dbReference type="CTD" id="183120"/>
    <dbReference type="WormBase" id="C32C4.1f">
        <property type="protein sequence ID" value="CE45209"/>
        <property type="gene ID" value="WBGene00007862"/>
        <property type="gene designation" value="kvs-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007862">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N132">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein CBG09661"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="Ion_trans_dom"/>
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        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
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        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
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        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
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        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF121">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="69"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBO22679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C32C4.1f"/>
        </source>
    </evidence>
    <sequence length="535" mass="61131" checksum="0A74AEAA62293BAA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>D9N133</accession>
    <name>D9N133_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">kvs-2</name>
        <name evidence="17" type="ORF">C32C4.1</name>
        <name evidence="15" type="ORF">CELE_C32C4.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO22680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256239.1">
        <property type="nucleotide sequence ID" value="NM_001269310.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N133"/>
    <dbReference type="SMR" id="D9N133"/>
    <dbReference type="GeneID" id="183120"/>
    <dbReference type="AGR" id="WB:WBGene00007862"/>
    <dbReference type="CTD" id="183120"/>
    <dbReference type="WormBase" id="C32C4.1g">
        <property type="protein sequence ID" value="CE45168"/>
        <property type="gene ID" value="WBGene00007862"/>
        <property type="gene designation" value="kvs-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007862">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N133">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000088">
        <property type="entry name" value="Protein CBG09661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000176">
        <property type="entry name" value="Protein CBG09661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
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        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF121">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="63"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBO22680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C32C4.1g"/>
        </source>
    </evidence>
    <sequence length="524" mass="59826" checksum="2FC1053B1D6C07B1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D9N135</accession>
    <name>D9N135_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_T11F9.21</name>
        <name evidence="1 3" type="ORF">T11F9.21</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO25503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256328.1">
        <property type="nucleotide sequence ID" value="NM_001269399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N135"/>
    <dbReference type="GeneID" id="13215336"/>
    <dbReference type="AGR" id="WB:WBGene00194712"/>
    <dbReference type="CTD" id="13215336"/>
    <dbReference type="WormBase" id="T11F9.21b">
        <property type="protein sequence ID" value="CE45128"/>
        <property type="gene ID" value="WBGene00194712"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5831709at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N135">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBO25503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T11F9.21b"/>
        </source>
    </evidence>
    <sequence length="17" mass="1938" checksum="0326B03A94578A1C" modified="2010-10-05" version="1">MIAFACLARKNRENEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>D9N138</accession>
    <name>D9N138_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">micu-3</name>
        <name evidence="12" type="ORF">C56A3.6</name>
        <name evidence="10" type="ORF">CELE_C56A3.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO23317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256520.1">
        <property type="nucleotide sequence ID" value="NM_001269591.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N138"/>
    <dbReference type="SMR" id="D9N138"/>
    <dbReference type="GeneID" id="179837"/>
    <dbReference type="AGR" id="WB:WBGene00008345"/>
    <dbReference type="CTD" id="179837"/>
    <dbReference type="WormBase" id="C56A3.6c">
        <property type="protein sequence ID" value="CE45118"/>
        <property type="gene ID" value="WBGene00008345"/>
        <property type="gene designation" value="micu-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859791at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N138">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15900">
        <property type="entry name" value="EFh_MICU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF13">
        <property type="entry name" value="MITOCHONDRIAL CALCIUM UPTAKE 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBO23317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C56A3.6c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="D9N138"/>
        </source>
    </evidence>
    <sequence length="417" mass="48136" checksum="F57342AC9C85D6E4" modified="2010-10-05" version="1">MKRVLSRFWGFSTKHRQHILNQRIVERTSARNVAVLTAAGIGTSIGAYQLIDTARAGILDGSDDASRHNVTTDHKLTKRELRFLQFASVEYDDVIYMSPMDFIDSLTLDAPRERVYRRVLKEKDIQRILKKTPPFRSGGKHFFRTMDQSGIISYSEYIFLLTLLTKSKAAFRIAFLMFDEDDNGNIDRDEFMLIARMFASKAATLSGTRLVHKSEEEVRKQDTTLLLHLFGLRGNATLSFDEFQQFYENLQEELMEIEFYEFARGKTAISPVDFARLILRYSIVNFDDYHKYLQRVQEKSDDDEPGISLSQWATFSRFLNNLAEFQSAVRLYVNSNVPVSEPEFARAVGCTIGKELDPVVVSMIFRIFDENNDGTLSYPEFLAVMSDRLHRGLRGRLEKPWGWKPFKNCVISEVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>D9N139</accession>
    <name>D9N139_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">micu-3</name>
        <name evidence="12" type="ORF">C56A3.6</name>
        <name evidence="10" type="ORF">CELE_C56A3.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO23318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256521.1">
        <property type="nucleotide sequence ID" value="NM_001269592.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N139"/>
    <dbReference type="SMR" id="D9N139"/>
    <dbReference type="GeneID" id="179837"/>
    <dbReference type="AGR" id="WB:WBGene00008345"/>
    <dbReference type="CTD" id="179837"/>
    <dbReference type="WormBase" id="C56A3.6d">
        <property type="protein sequence ID" value="CE32339"/>
        <property type="gene ID" value="WBGene00008345"/>
        <property type="gene designation" value="micu-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859791at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008345">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N139">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15900">
        <property type="entry name" value="EFh_MICU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF13">
        <property type="entry name" value="MITOCHONDRIAL CALCIUM UPTAKE 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBO23318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C56A3.6d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="D9N139"/>
        </source>
    </evidence>
    <sequence length="458" mass="52766" checksum="C8AE6652C8A9BEFE" modified="2010-10-05" version="1">MKRVLSRFWGFSTKHRQHILNQRIVERTSARNVAVLTAAGIGTSIGAYQLIDTARAGILDGSDDASRHNVTTDHKLTKRELRFLQFASVEYDDVIYMSPMDFIDSLTLDAPRERVYRRVLKEKDIQRILKKTPPFRSGGKHFFRTMDQSGIISYSEYIFLLTLLTKSKAAFRIAFLMFDEDDNGNIDRDEFMLIRSLTSSLRSTTRVQPSTASDEEDRRESCQLDAADYHFAVSRIGADRLFTGADSYAVMFTKSEEEVRKQDTTLLLHLFGLRGNATLSFDEFQQFYENLQEELMEIEFYEFARGKTAISPVDFARLILRYSIVNFDDYHKYLQRVQEKSDDDEPGISLSQWATFSRFLNNLAEFQSAVRLYVNSNVPVSEPEFARAVGCTIGKELDPVVVSMIFRIFDENNDGTLSYPEFLAVMSDRLHRGLRGRLEKPWGWKPFKNCVISEVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D9N140</accession>
    <name>D9N140_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F07B10.7</name>
        <name evidence="2 4" type="ORF">F07B10.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO23610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001269382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N140"/>
    <dbReference type="GeneID" id="6418715"/>
    <dbReference type="KEGG" id="cel:CELE_F07B10.7"/>
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    <dbReference type="CTD" id="6418715"/>
    <dbReference type="WormBase" id="F07B10.7b">
        <property type="protein sequence ID" value="CE45208"/>
        <property type="gene ID" value="WBGene00077514"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1289990_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N140">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46891:SF12">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46891">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBO23610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F07B10.7b"/>
        </source>
    </evidence>
    <sequence length="214" mass="24653" checksum="77C17FA499471D43" modified="2010-10-05" version="1">MENPNNIISCDFNQYPAWKNFLVLWAPVYGLPVYVAAVYLLRVHSENQSHYVLASQSIAVLLNYIELADMSSFFFPQYVIPVLGVQVDGILRDVYPRAAVYLIIGMTTHHVINSTTLFTAHCRLMLLSKSLTIQNDSIVRFVKLSNKFAYVGYILLVAAVFDYIYYSLLTQAHQGTAFTLFYVLSHSKIRKVFRRWLRPPRINSDRVFQLSNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D9N141</accession>
    <name>D9N141_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein rnp-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rnp-1</name>
        <name evidence="2" type="ORF">CELE_ZK863.7</name>
        <name evidence="4" type="ORF">ZK863.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO26901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256409.1">
        <property type="nucleotide sequence ID" value="NM_001269480.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N141"/>
    <dbReference type="GeneID" id="179672"/>
    <dbReference type="AGR" id="WB:WBGene00004384"/>
    <dbReference type="CTD" id="179672"/>
    <dbReference type="WormBase" id="ZK863.7b">
        <property type="protein sequence ID" value="CE45158"/>
        <property type="gene ID" value="WBGene00004384"/>
        <property type="gene designation" value="rnp-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_922053_0_0_1"/>
    <dbReference type="OrthoDB" id="79941at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004384">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N141">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBO26901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZK863.7b"/>
        </source>
    </evidence>
    <sequence length="29" mass="3251" checksum="A7276C5D215CB14D" modified="2010-10-05" version="1">MTTQQYLQQIQHQQATGSPAPVPAPPRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>D9N144</accession>
    <name>D9N144_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">gnrr-2</name>
        <name evidence="11" type="ORF">C15H11.2</name>
        <name evidence="9" type="ORF">CELE_C15H11.2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO22274.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256584.2">
        <property type="nucleotide sequence ID" value="NM_001269655.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N144"/>
    <dbReference type="GeneID" id="182647"/>
    <dbReference type="AGR" id="WB:WBGene00007614"/>
    <dbReference type="CTD" id="182647"/>
    <dbReference type="WormBase" id="C15H11.2b">
        <property type="protein sequence ID" value="CE48308"/>
        <property type="gene ID" value="WBGene00007614"/>
        <property type="gene designation" value="gnrr-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_15_7_1"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007614">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N144">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBO22274.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C15H11.2b"/>
        </source>
    </evidence>
    <sequence length="257" mass="29855" checksum="B24C6E97D797C22C" modified="2013-05-01" version="2">MVCIALYRLSALRYPLWVNAVGHSRVPRMLILAWALAVVTMLPQMLVWNEVQFSNITQCVTVWTEIINKREKLSESELRNMKLYSIQNATIIFYIPLMILVACYVLILKDIYKTLNTDTECSSAAYLSEMSSSKTGGKAALHKKDQESFVTLTTRTVRGQEKFRRAKVRSLRITLLLILTYAVTWLPYNLLSWWMVLHWDSYRENLDSNYILNSLVVLNSVINPFIYGRCQGIRFLFKCRERLAAPKTKKICKLLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>D9N145</accession>
    <name>D9N145_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_F58G11.4</name>
        <name evidence="7 9" type="ORF">F58G11.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO24734.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256537.2">
        <property type="nucleotide sequence ID" value="NM_001269608.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N145"/>
    <dbReference type="GeneID" id="186546"/>
    <dbReference type="AGR" id="WB:WBGene00010282"/>
    <dbReference type="CTD" id="186546"/>
    <dbReference type="WormBase" id="F58G11.4b">
        <property type="protein sequence ID" value="CE47966"/>
        <property type="gene ID" value="WBGene00010282"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027024_3_1_1"/>
    <dbReference type="OrthoDB" id="370281at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010282">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N145">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF17">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672386" evidence="6">
        <location>
            <begin position="19"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBO24734.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F58G11.4b"/>
        </source>
    </evidence>
    <sequence length="384" mass="42695" checksum="205136CF6097C6D8" modified="2013-02-06" version="2">MCVGYLLMLLSNCLFLLADHVPAETSAFYIMLCRFLGGLGMGNTSTLRTTLTAHSMSDDRAKAMSVFIGGRALGLILGPGLQLIFLFLGDTGLQLIGPLHIHSHNAAAFISIVLNISAIVALFTVYHEIERNGNSCSQRSVEDDENWPRPDKLAMFVCMLTRYCQNFTYYAIETLAPAFMMMMFNMERDSAVGTMSIIFFIAGVFALSLYSTFVFTDVARKLNIGKVNTISLIIFIIYVLTTYQWPYIPTNVVVNTDGTHGGCDYSLYSWCLGLPKTSQAFFYIGYIIAFGGCVPFINVGDATLYSKLFNPVGQALEQSLYDVSQVFARVVAPVLCTAIYASFGPQRVWELLFAQLVVVTALWIAFAHRMIPLRPKPRPVFYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D9N146</accession>
    <name>D9N146_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_K09G1.1</name>
        <name evidence="8 10" type="ORF">K09G1.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO25097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256124.1">
        <property type="nucleotide sequence ID" value="NM_001269195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N146"/>
    <dbReference type="GeneID" id="179346"/>
    <dbReference type="KEGG" id="cel:CELE_K09G1.1"/>
    <dbReference type="AGR" id="WB:WBGene00010727"/>
    <dbReference type="CTD" id="179346"/>
    <dbReference type="WormBase" id="K09G1.1d">
        <property type="protein sequence ID" value="CE45173"/>
        <property type="gene ID" value="WBGene00010727"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10028364at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010727">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N146">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF52">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="90"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBO25097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="K09G1.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="D9N146"/>
        </source>
    </evidence>
    <sequence length="240" mass="26509" checksum="A27CF8BA3001637A" modified="2010-10-05" version="1">MKNLRFESHRHNGGAAEAEFNFGEVRRAAASFQENPQEDGKMSETEIITIRKPDGTTETKTVEKKKLQFHMANKVKIIPTNRQGQLNTGYLATLAGVLKIAEIVLSFIAFILAICADRRTTTAAWTEHISFETLLIVSALLLGYVVFPHLTIKDEATREGLIVVELIFYGVNTLLYFISIWLMVHLSASWGTDGRGAAIMTAVICVALTVLFAIETVVKLKAWRGENEPTTVIEAGNAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>D9N148</accession>
    <name>D9N148_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Core-2/I-Branching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_F26D2.3</name>
        <name evidence="7 9" type="ORF">F26D2.3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBO24093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9N148"/>
    <dbReference type="AGR" id="WB:WBGene00009148"/>
    <dbReference type="WormBase" id="F26D2.3c">
        <property type="protein sequence ID" value="CE45126"/>
        <property type="gene ID" value="WBGene00009148"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1311107_0_0_1"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009148">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D9N148">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671:SF1">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBO24093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F26D2.3c"/>
        </source>
    </evidence>
    <sequence length="210" mass="24350" checksum="A151AC797F0A4B6B" modified="2010-10-05" version="1">MSQQRQLPYSVILLILGFTFIIYLVSPTTLLNLFYGEFDPYLSADRKVVVYEKMIEALRNMDKYCKDRRFYCKRPETRHVDCRRVLRGDKAYLQSLTGINRIPLIENPFLNLTCSAIKNRIIPKSSQFKLLMLNGTAFARIVFADYEFIEKQVQASYHPQNFFCFAVDANSSAEFQKRMKALERCLPNVFVLPGRFTSNCSAPCLPDSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G8JYD7</accession>
    <name>G8JYD7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermatogenesis-defective protein 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">spe-39</name>
        <name evidence="1" type="ORF">CELE_ZC404.3</name>
        <name evidence="3" type="ORF">ZC404.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD72491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380005.1">
        <property type="nucleotide sequence ID" value="NM_001392537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JYD7"/>
    <dbReference type="GeneID" id="179071"/>
    <dbReference type="AGR" id="WB:WBGene00004975"/>
    <dbReference type="CTD" id="179071"/>
    <dbReference type="WormBase" id="ZC404.3b">
        <property type="protein sequence ID" value="CE29620"/>
        <property type="gene ID" value="WBGene00004975"/>
        <property type="gene designation" value="spe-39"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2529515_0_0_1"/>
    <dbReference type="OrthoDB" id="9977282at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004975">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JYD7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD72491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="ZC404.3b"/>
        </source>
    </evidence>
    <sequence length="84" mass="10016" checksum="77EE5CBFAD28297C" modified="2012-01-25" version="1">MALRRKFTFELPEDSYWNESDSNSSGLFDDLQSKQLEQPSTISSVAMRLRSRTSDRRTQRQLPQMFHCKLTEELLLCQTRRIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>G8JYE4</accession>
    <name>G8JYE4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Glutamate carboxypeptidase 2 homolog</fullName>
            <ecNumber evidence="16">3.4.17.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Glutamate carboxypeptidase II homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 24" type="primary">gcp-2.1</name>
        <name evidence="22" type="ORF">CELE_R57.1</name>
        <name evidence="24" type="ORF">R57.1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.</text>
            <dbReference type="EC" id="3.4.17.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.21" evidence="16"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD73108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024866.1">
        <property type="nucleotide sequence ID" value="NM_001029695.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JYE4"/>
    <dbReference type="SMR" id="G8JYE4"/>
    <dbReference type="MEROPS" id="M28.A19"/>
    <dbReference type="PeptideAtlas" id="G8JYE4"/>
    <dbReference type="GeneID" id="180386"/>
    <dbReference type="AGR" id="WB:WBGene00020082"/>
    <dbReference type="CTD" id="180386"/>
    <dbReference type="WormBase" id="R57.1c">
        <property type="protein sequence ID" value="CE12844"/>
        <property type="gene ID" value="WBGene00020082"/>
        <property type="gene designation" value="gcp-2.1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020082">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JYE4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000009">
        <property type="entry name" value="Glutamate carboxypeptidase 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000033">
        <property type="entry name" value="Glutamate carboxypeptidase 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF77">
        <property type="entry name" value="GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 22" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PA" evidence="19">
        <location>
            <begin position="161"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="21">
        <location>
            <begin position="348"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="20">
        <location>
            <begin position="616"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00075421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCD73108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WormBase" id="R57.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PeptideAtlas" id="G8JYE4"/>
        </source>
    </evidence>
    <sequence length="751" mass="83683" checksum="1A08A44974FA29C7" modified="2012-01-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>G8JYE5</accession>
    <name>G8JYE5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">gldi-11</name>
        <name evidence="6" type="ORF">CELE_ZK546.14</name>
        <name evidence="8" type="ORF">ZK546.14</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD73225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380032.1">
        <property type="nucleotide sequence ID" value="NM_001393056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JYE5"/>
    <dbReference type="SMR" id="G8JYE5"/>
    <dbReference type="PeptideAtlas" id="G8JYE5"/>
    <dbReference type="GeneID" id="173854"/>
    <dbReference type="AGR" id="WB:WBGene00022765"/>
    <dbReference type="CTD" id="173854"/>
    <dbReference type="WormBase" id="ZK546.14b">
        <property type="protein sequence ID" value="CE33503"/>
        <property type="gene ID" value="WBGene00022765"/>
        <property type="gene designation" value="gldi-11"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030916_0_0_1"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022765">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JYE5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="250"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD73225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="ZK546.14b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="G8JYE5"/>
        </source>
    </evidence>
    <sequence length="454" mass="52274" checksum="C19E4D3A5701BA3F" modified="2012-01-25" version="1">MLSFCNLIPVNSWGFDDDVKESLKMRKHSLVNRQLSKKERKSMSAQQKQHLAKGLGLVPNTVQEVLEWMSKSKQHSKVQPQKVVAPVKRPADQNKNKEKVVKKDQKKQDKKADSDSEEDDSSDDEEKEETDEPVAKKQKKEESSDDDEDSEDGEEPEGNNGAVEAEDSDSTDEEEETPSKPNKTVAQSTLKSNGKIDKEIQKLEDDEDNESPEIRRQIALLRLQKKLKEMKVERKGKGPAKVTSAMAEKMAEEKRLKRRESKLKLKQRRAEEKKGKEAAAQVKKETVESTENGNEPVEKQKSGISFNNLKFEIKEDKQRGKKQRTAKKDRALKLTGRDYKSLIAKVEETKATIAKVREADPHKATIMEDELKWEKTLKRAAGGKVKDNLGMLKKALVKKNKMKDRRKQKWENRENKTEGEKQTKQDKRKKNLQKRIDDVKKRKMNKLRNKGRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYN7</accession>
    <name>H2KYN7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">smk-1</name>
        <name evidence="6" type="ORF">CELE_F41E6.4</name>
        <name evidence="8" type="ORF">F41E6.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMEK family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD64094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023910.2">
        <property type="nucleotide sequence ID" value="NM_001028739.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYN7"/>
    <dbReference type="PeptideAtlas" id="H2KYN7"/>
    <dbReference type="GeneID" id="179243"/>
    <dbReference type="AGR" id="WB:WBGene00018285"/>
    <dbReference type="CTD" id="179243"/>
    <dbReference type="WormBase" id="F41E6.4b">
        <property type="protein sequence ID" value="CE41240"/>
        <property type="gene ID" value="WBGene00018285"/>
        <property type="gene designation" value="smk-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004909_2_0_1"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018285">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYN7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010165">
        <property type="term" value="P:response to X-ray"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="5">
        <location>
            <begin position="84"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="688"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="696"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="764"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="838"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD64094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F41E6.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYN7"/>
        </source>
    </evidence>
    <sequence length="849" mass="96182" checksum="D232018247F4037B" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYP8</accession>
    <name>H2KYP8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pantothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">pnk-1</name>
        <name evidence="7" type="ORF">C10G11.5</name>
        <name evidence="5" type="ORF">CELE_C10G11.5</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD64182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_740868.1">
        <property type="nucleotide sequence ID" value="NM_170879.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYP8"/>
    <dbReference type="SMR" id="H2KYP8"/>
    <dbReference type="GeneID" id="172327"/>
    <dbReference type="AGR" id="WB:WBGene00004068"/>
    <dbReference type="CTD" id="172327"/>
    <dbReference type="WormBase" id="C10G11.5b">
        <property type="protein sequence ID" value="CE30488"/>
        <property type="gene ID" value="WBGene00004068"/>
        <property type="gene designation" value="pnk-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275583at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004068">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYP8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000009">
        <property type="entry name" value="PaNtothenate Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD64182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C10G11.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYP8"/>
        </source>
    </evidence>
    <sequence length="392" mass="43613" checksum="66B3C4A6A6EA209C" modified="2012-03-21" version="1">MGHTSVTSSRRISPRGSPPNLRRTPPKIRKVLVLREKRAAATEDQIMDDLLLSSKLKRVDSATGSVSPRVCAADALPTTTPAASTALRQTQKAPKTPYVILPASDTFEKFRKTSRVSVDIGGTLIKVVYSSVMDEELPEESLNGHTRKYAYEDGKRVLVNFKKFTDMDRFINFLKEVWTDRKRGDVIHCTGGGSYKYSEIIMKELGVRLQRTDEMRSLIFGVNFLLSTNVDESFTYHHDAIGRNKFQYRPIAADLIYPFLLVNIGTGISILKVDSPTSYERVGGSSMGGGTFMGLGSLLTPAQNFDELLEMANRGDHRNVDKLVCDIYGGAYDELGLKADLIAGSMAKCNRFEETTKKQQHKPEDIAKSLLLMVSNNIGQIFSDGIFVWHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYP9</accession>
    <name>H2KYP9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Verprolin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C10G11.6</name>
        <name evidence="2" type="ORF">CELE_C10G11.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD64188.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001361942.1">
        <property type="nucleotide sequence ID" value="NM_001374901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYP9"/>
    <dbReference type="GeneID" id="182506"/>
    <dbReference type="AGR" id="WB:WBGene00015686"/>
    <dbReference type="CTD" id="182506"/>
    <dbReference type="WormBase" id="C10G11.6a">
        <property type="protein sequence ID" value="CE53680"/>
        <property type="gene ID" value="WBGene00015686"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_772182_0_0_1"/>
    <dbReference type="OrthoDB" id="10393918at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015686">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYP9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD64188.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C10G11.6a"/>
        </source>
    </evidence>
    <sequence length="348" mass="39105" checksum="CA37D275D95EA586" modified="2019-12-11" version="2">MKYQLDEDDEEGLVHSPHSSFTTENLRSSDPMFFDINRWKREVGTVIRSENHVLIHNDDEIRNAISKAMLLDSASEHLQRKRKRLIDILDEQRVEEGITGKKLFEEKRSKIQEQLGRAYPALENKITKAFYRSSLPIVSPDVRRPPPSLSIPLPPMHIPPPSVYFISTPSIYSTAKSSTSTVTSKLSKAIITPTPPQPLSSPHLLPPRTSDYRKTYAGNFKRSDTSKEGKHVFDATKFKAMVPRDNTSWRTPFHPTPVPPPSIHTFLKGCLPSPFVRKIPEITPRRHSTGTENRPSSPLGRRSLPPPGLVGINVRGLFVGNRSNRQQTPEPDESPKSSSSSGTPSDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYQ1</accession>
    <name>H2KYQ1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cysteine/serine-rich nuclear protein N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="ORF">C41D11.3</name>
        <name evidence="11" type="ORF">CELE_C41D11.3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD64259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370421.1">
        <property type="nucleotide sequence ID" value="NM_001382924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYQ1"/>
    <dbReference type="GeneID" id="3565087"/>
    <dbReference type="AGR" id="WB:WBGene00016562"/>
    <dbReference type="CTD" id="3565087"/>
    <dbReference type="WormBase" id="C41D11.3a">
        <property type="protein sequence ID" value="CE40195"/>
        <property type="gene ID" value="WBGene00016562"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544270_0_0_1"/>
    <dbReference type="OrthoDB" id="5946974at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016562">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYQ1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF9">
        <property type="entry name" value="AXIN1 UP-REGULATED 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02031">
        <property type="entry name" value="CYSSERRICHNP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="244"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD64259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C41D11.3a"/>
        </source>
    </evidence>
    <sequence length="488" mass="54495" checksum="38F8029F29DA9E39" modified="2012-03-21" version="1">MVPLVKKQMSIDEKIMEDDEDEGFGDSMKTIKRGQGSSLARSLSLKLSPKTDQQKPIGADTEKSCSTPSLPTAPLLSRQGSTSSLRFKVSPSTFLKPIATPIIDVSPTPRPDPEPLRIIVAAAAAAPVESTELSEPSTSKTPEQKAEPAMQKSALRKHAANFSVREEIFIPGIRRKKIRFSGLHVHYFDRRQGGSTVPTEGDISLDMHNKHHSHRYFSLSTGKRPILDLLLYADDDLSDGEVIDPDSDEDRDYDEYASAKSIPRINQRHRIKLLKKSGVKVEKNTDAIDSLRNTRVECGCSCENGVCLPETCQCAIDGIHCQVDGGEWPTQPCACFAETCTNPEGRTFYDPEAVHEFRQRTIMNWRASQKTGISGSPVVKKFADSDEEDDKAKTWLLKNAIPIKLEESPTKYPVTPVYTRRSRSSLSDIRESTSETTGSITPSTSLSERIKAMQHLDNEVCVEQEEKDEDDAYFMDNKVRFLLRKYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYQ2</accession>
    <name>H2KYQ2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IgGFc_binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C12D12.1</name>
        <name evidence="3" type="ORF">CELE_C12D12.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD64306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508602.1">
        <property type="nucleotide sequence ID" value="NM_076201.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYQ2"/>
    <dbReference type="PeptideAtlas" id="H2KYQ2"/>
    <dbReference type="GeneID" id="180642"/>
    <dbReference type="AGR" id="WB:WBGene00015713"/>
    <dbReference type="CTD" id="180642"/>
    <dbReference type="WormBase" id="C12D12.1b">
        <property type="protein sequence ID" value="CE29576"/>
        <property type="gene ID" value="WBGene00015713"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363382_0_0_1"/>
    <dbReference type="OrthoDB" id="5868818at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015713">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYQ2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051298">
        <property type="entry name" value="Heme_transport/Cell_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22917:SF6">
        <property type="entry name" value="EG:8D8.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22917">
        <property type="entry name" value="HEMOPEXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003563261" evidence="2">
        <location>
            <begin position="20"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD64306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C12D12.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYQ2"/>
        </source>
    </evidence>
    <sequence length="648" mass="69155" checksum="050EEFE6A298C0BC" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYQ7</accession>
    <name>H2KYQ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rgs-7</name>
        <name evidence="2" type="ORF">CELE_F56B6.2</name>
        <name evidence="4" type="ORF">F56B6.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD64323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123153.1">
        <property type="nucleotide sequence ID" value="NM_001129681.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYQ7"/>
    <dbReference type="SMR" id="H2KYQ7"/>
    <dbReference type="GeneID" id="180645"/>
    <dbReference type="AGR" id="WB:WBGene00004350"/>
    <dbReference type="CTD" id="180645"/>
    <dbReference type="WormBase" id="F56B6.2f">
        <property type="protein sequence ID" value="CE42123"/>
        <property type="gene ID" value="WBGene00004350"/>
        <property type="gene designation" value="rgs-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1157316_0_0_1"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004350">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYQ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000038">
        <property type="entry name" value="Regulator of G-protein signaling rgs-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF259">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="103"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD64323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F56B6.2f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYQ7"/>
        </source>
    </evidence>
    <sequence length="240" mass="27599" checksum="71BC107B3E235CE1" modified="2012-03-21" version="1">MAGSNSSAMSLDTTDFDFTSTIPSTPSSFDDFFLIPTPAKTSRRRFTVAPSDIIRLKRRLVQHRPNRGPISRTLSYLRSKMDLALSTSSLYPSRDDVRQWEISFESLLNNKFGCALFRQFLKKEFSDENMDFWLECEEFKKMKDGKKSTTQKAIEIYSEFVAEHSPKEVNLDSDTRAATKAAVEAGCKPDTFALAQSRVEQLMSKDSYRRFLRDRLFLDLLESYEITDKEDKPSSSKDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYQ8</accession>
    <name>H2KYQ8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rgs-7</name>
        <name evidence="3" type="ORF">CELE_F56B6.2</name>
        <name evidence="5" type="ORF">F56B6.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD64324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123154.1">
        <property type="nucleotide sequence ID" value="NM_001129682.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYQ8"/>
    <dbReference type="SMR" id="H2KYQ8"/>
    <dbReference type="GeneID" id="180645"/>
    <dbReference type="AGR" id="WB:WBGene00004350"/>
    <dbReference type="CTD" id="180645"/>
    <dbReference type="WormBase" id="F56B6.2g">
        <property type="protein sequence ID" value="CE42124"/>
        <property type="gene ID" value="WBGene00004350"/>
        <property type="gene designation" value="rgs-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059863_1_0_1"/>
    <dbReference type="OMA" id="FHHTETH"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004350">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYQ8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000038">
        <property type="entry name" value="Regulator of G-protein signaling rgs-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF259">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="78"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD64324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F56B6.2g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYQ8"/>
        </source>
    </evidence>
    <sequence length="215" mass="24983" checksum="05D4AA8538CE2C70" modified="2012-03-21" version="1">MLSVTYPMIAKTNSQILTKFHHTETHQSTPNLHHHHHHHNISGPISRTLSYLRSKMDLALSTSSLYPSRDDVRQWEISFESLLNNKFGCALFRQFLKKEFSDENMDFWLECEEFKKMKDGKKSTTQKAIEIYSEFVAEHSPKEVNLDSDTRAATKAAVEAGCKPDTFALAQSRVEQLMSKDSYRRFLRDRLFLDLLESYEITDKEDKPSSSKDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYR0</accession>
    <name>H2KYR0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srj-32</name>
        <name evidence="2" type="ORF">CELE_F07G11.5</name>
        <name evidence="4" type="ORF">F07G11.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD64336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256083.1">
        <property type="nucleotide sequence ID" value="NM_001269154.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYR0"/>
    <dbReference type="GeneID" id="191944"/>
    <dbReference type="KEGG" id="cel:CELE_F07G11.5"/>
    <dbReference type="AGR" id="WB:WBGene00005617"/>
    <dbReference type="CTD" id="191944"/>
    <dbReference type="WormBase" id="F07G11.5b">
        <property type="protein sequence ID" value="CE45481"/>
        <property type="gene ID" value="WBGene00005617"/>
        <property type="gene designation" value="srj-32"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036335_0_1_1"/>
    <dbReference type="OrthoDB" id="5788320at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005617">
        <property type="expression patterns" value="Expressed in adult organism"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYR0">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019423">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srj"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45907">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45907:SF21">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10319">
        <property type="entry name" value="7TM_GPCR_Srj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD64336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F07G11.5b"/>
        </source>
    </evidence>
    <sequence length="204" mass="23514" checksum="5643FE9DDC2AF15B" modified="2012-03-21" version="1">MLLLAIRCSLIACTYTILISHFVYRYLAVLGSIFINRLFPYFMIVTLLFCVIASMFWIMIAYFVAVPNFEVRHYIQQNMYEIYGADSITLNFFALLYQIRKKLQSDRYRMSAGTAKMQLELLRSLVVQTVIPIIFSLAPCMLSWFTPMFNLKLDKWLNYTSAVPLSAFPFIDPFAVILCLPAFRRRLLGNAKPNTVVVSVASVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYR2</accession>
    <name>H2KYR2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FCH domain only protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">fcho-1</name>
        <name evidence="10" type="ORF">CELE_F56D12.6</name>
        <name evidence="12" type="ORF">F56D12.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD64351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_493948.1">
        <property type="nucleotide sequence ID" value="NM_061547.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYR2"/>
    <dbReference type="SMR" id="H2KYR2"/>
    <dbReference type="PeptideAtlas" id="H2KYR2"/>
    <dbReference type="GeneID" id="173511"/>
    <dbReference type="AGR" id="WB:WBGene00018974"/>
    <dbReference type="CTD" id="173511"/>
    <dbReference type="WormBase" id="F56D12.6b">
        <property type="protein sequence ID" value="CE11256"/>
        <property type="gene ID" value="WBGene00018974"/>
        <property type="gene designation" value="fcho-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5593455at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018974">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYR2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF15">
        <property type="entry name" value="AT02057P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="9">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="678"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="80"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD64351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F56D12.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYR2"/>
        </source>
    </evidence>
    <sequence length="951" mass="106547" checksum="DD0F1FBCC93AFA10" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYR5</accession>
    <name>H2KYR5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">ensh-1</name>
        <name evidence="3" type="ORF">CELE_D1009.3</name>
        <name evidence="5" type="ORF">D1009.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD64416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024509.1">
        <property type="nucleotide sequence ID" value="NM_001029338.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYR5"/>
    <dbReference type="SMR" id="H2KYR5"/>
    <dbReference type="PeptideAtlas" id="H2KYR5"/>
    <dbReference type="GeneID" id="181135"/>
    <dbReference type="AGR" id="WB:WBGene00017013"/>
    <dbReference type="CTD" id="181135"/>
    <dbReference type="WormBase" id="D1009.3b">
        <property type="protein sequence ID" value="CE04287"/>
        <property type="gene ID" value="WBGene00017013"/>
        <property type="gene designation" value="ensh-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548877_0_0_1"/>
    <dbReference type="OrthoDB" id="7972392at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017013">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYR5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF445">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="213"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD64416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="D1009.3b"/>
        </source>
    </evidence>
    <sequence length="463" mass="52450" checksum="EADF4700700B5CDD" modified="2012-03-21" version="1">MMQDTKDEHLTSFAENPTKSVERDALVEPQFTRPEQVEKTHVEEAKWPWGKGKKNEKMPRFLVTILLICLLVAALLIALIAIVWALNSNSASVREPEIVYTIPSRDNQKDNVVHARSNIPKTLKKSLDLLEEDTTTITTTTSQTPDDYDTTEPFVEEEEYHLEEATEHHEIATIEATTPEPSEIATKKPIIYYSPPTTPKTTTSTGYLQFYDSIDGDASDNCLERLALGSPSGVYSIQSVEKFQAFCDMDTTTGGWTVIQRRVDGDGSFHRGTMKKFVEGFGNLQGSHWLGLEKLHNLAPIGATPAILRIEIQGETCDLTCSKRFANTWVGEWKVNFGKKQDGYKIQITEEGVGNLTYNGVDPFFGANGRRFSTNDNDQDENTFMNCAQFRMVGPWWHPKSCSDVGLNGYFQTTSEKYDVKDRNQNAKRYFVWAFDKQIYNGYPYTIHVRKSTMLLKTGDPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYR8</accession>
    <name>H2KYR8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_F25B4.8</name>
        <name evidence="5 7" type="ORF">F25B4.8</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD64511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYR8"/>
    <dbReference type="SMR" id="H2KYR8"/>
    <dbReference type="PeptideAtlas" id="H2KYR8"/>
    <dbReference type="AGR" id="WB:WBGene00017771"/>
    <dbReference type="WormBase" id="F25B4.8b">
        <property type="protein sequence ID" value="CE30762"/>
        <property type="gene ID" value="WBGene00017771"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_7_3_1"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017771">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYR8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="6"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD64511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F25B4.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYR8"/>
        </source>
    </evidence>
    <sequence length="112" mass="12655" checksum="57DA791BB4A483D6" modified="2012-03-21" version="1">MSEVQHFGSCHCGAVKWSFTGPEVLDGCRCNCSVCDKKQNQHCIIKLDRFKLLEGEDKITVYRFNTGLAQHKFCSICGVQSFYHPRSNPDAVGKPESTWCQAVPSWLDLPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYR9</accession>
    <name>H2KYR9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T26C11.4</name>
        <name evidence="2 4" type="ORF">T26C11.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD64523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256989.1">
        <property type="nucleotide sequence ID" value="NM_001270060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYR9"/>
    <dbReference type="GeneID" id="180502"/>
    <dbReference type="KEGG" id="cel:CELE_T26C11.4"/>
    <dbReference type="AGR" id="WB:WBGene00020830"/>
    <dbReference type="CTD" id="180502"/>
    <dbReference type="WormBase" id="T26C11.4a">
        <property type="protein sequence ID" value="CE46378"/>
        <property type="gene ID" value="WBGene00020830"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8194935at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020830">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYR9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD64523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T26C11.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYR9"/>
        </source>
    </evidence>
    <sequence length="570" mass="65496" checksum="2B0519F19AEE8AD8" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ01</accession>
    <name>H2KZ01_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tent-5</name>
        <name evidence="8" type="synonym">pqn-44</name>
        <name evidence="6" type="ORF">CELE_F55A12.9</name>
        <name evidence="8" type="ORF">F55A12.9</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:11333"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TENT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD65446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_740852.1">
        <property type="nucleotide sequence ID" value="NM_170865.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ01"/>
    <dbReference type="SMR" id="H2KZ01"/>
    <dbReference type="GeneID" id="172187"/>
    <dbReference type="AGR" id="WB:WBGene00004131"/>
    <dbReference type="CTD" id="172187"/>
    <dbReference type="WormBase" id="F55A12.9c">
        <property type="protein sequence ID" value="CE30809"/>
        <property type="gene ID" value="WBGene00004131"/>
        <property type="gene designation" value="tent-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10065073at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004131">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ01">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012937">
        <property type="entry name" value="TET5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974:SF36">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07984">
        <property type="entry name" value="NTP_transf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01153">
        <property type="entry name" value="DUF1693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD65446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F55A12.9c"/>
        </source>
    </evidence>
    <sequence length="465" mass="53624" checksum="49E3F3C018BE493D" modified="2012-03-21" version="1">MGKKKVVWKKVEGIVELAPHGTNRMRNGNGQNQQGNQQYQQCQNNYQNQQNHQNSNQGYQEPQNEQFVSRTMILAKGQMKRLRAVLEERVEIHGRGNFPTISTKLINLIRCLRQHMGSVQVEARDVRLNGGAASFVASSDDFSYADLDLIFPIQIDEESDENVEKQIFDAIRDSVFMTIRELMPDNIGKEKFDFETLKDVYIRKMIKVSTDNDKWSLFSLNNEYGRCIELKFVNKMRRQFEFSVDSFQIHLDPLLNELDECEQKKITIESMYGDVQQAMTHLHERLIDTVKPEEIRGGGLLKYCHLIIRGYKAAKPWNCRKLERYMCSRFFIDFPDLISQENKLRNYLDSHFGTSFNGATYDQWSSSGSDTDSEASTSQATTSSLLVTGQAKYDFLMLLYRVIDESTVCLMAHERNMSLNMIDRVAFQLSMQCYTPPNFSSGSSTPPRTTLFYLPPDAATWIPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ06</accession>
    <name>H2KZ06_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">clec-266</name>
        <name evidence="7" type="ORF">C25B8.4</name>
        <name evidence="5" type="ORF">CELE_C25B8.4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD65630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024427.1">
        <property type="nucleotide sequence ID" value="NM_001029256.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ06"/>
    <dbReference type="SMR" id="H2KZ06"/>
    <dbReference type="PeptideAtlas" id="H2KZ06"/>
    <dbReference type="GeneID" id="180932"/>
    <dbReference type="KEGG" id="cel:CELE_C25B8.4"/>
    <dbReference type="AGR" id="WB:WBGene00016088"/>
    <dbReference type="CTD" id="180932"/>
    <dbReference type="WormBase" id="C25B8.4a">
        <property type="protein sequence ID" value="CE27087"/>
        <property type="gene ID" value="WBGene00016088"/>
        <property type="gene designation" value="clec-266"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093598_0_0_1"/>
    <dbReference type="OrthoDB" id="5775138at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016088">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ06">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051379">
        <property type="entry name" value="C-type_Lectin_Receptor_IMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46746:SF9">
        <property type="entry name" value="CD209 ANTIGEN-LIKE PROTEIN C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46746">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003563880" evidence="3">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="65"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD65630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C25B8.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ06"/>
        </source>
    </evidence>
    <sequence length="212" mass="24758" checksum="7CF2230295E1C66E" modified="2012-03-21" version="1">MSRIFKLVLLVAAVGFVSTRFAQVKLFNWSYKDFGTNAFTDISLDQRQHYHDFPTGTCPDGWVRFSDSCYWIEQHKQSFAEAEKRCYEKNATLFVVNSQDEWDAVREHFPQTGYTWIGLVRFTHFEKSQDAPIWQTEGAVNPTRLNWLIRPYKPVSNGWSALANCAAHFSAAINWDASAYTYFQPCSFKFYSICERNGTILDFLNRKFDFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ18</accession>
    <name>H2KZ18_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="9">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ampd-1</name>
        <name evidence="13" type="ORF">C34F11.3</name>
        <name evidence="11" type="ORF">CELE_C34F11.3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AMP + H2O + H(+) = IMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.5.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="9"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD65832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_494974.3">
        <property type="nucleotide sequence ID" value="NM_062573.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ18"/>
    <dbReference type="SMR" id="H2KZ18"/>
    <dbReference type="PeptideAtlas" id="H2KZ18"/>
    <dbReference type="GeneID" id="173891"/>
    <dbReference type="AGR" id="WB:WBGene00016415"/>
    <dbReference type="CTD" id="173891"/>
    <dbReference type="WormBase" id="C34F11.3a">
        <property type="protein sequence ID" value="CE44871"/>
        <property type="gene ID" value="WBGene00016415"/>
        <property type="gene designation" value="ampd-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003782_4_0_1"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016415">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ18">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD65832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C34F11.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ18"/>
        </source>
    </evidence>
    <sequence length="784" mass="90109" checksum="E110EEC8D503840A" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ19</accession>
    <name>H2KZ19_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="9">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ampd-1</name>
        <name evidence="13" type="ORF">C34F11.3</name>
        <name evidence="11" type="ORF">CELE_C34F11.3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AMP + H2O + H(+) = IMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.5.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="9"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD65833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040752.2">
        <property type="nucleotide sequence ID" value="NM_001047287.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ19"/>
    <dbReference type="SMR" id="H2KZ19"/>
    <dbReference type="PaxDb" id="6239-C34F11.3c"/>
    <dbReference type="PeptideAtlas" id="H2KZ19"/>
    <dbReference type="GeneID" id="173891"/>
    <dbReference type="KEGG" id="cel:CELE_C34F11.3"/>
    <dbReference type="AGR" id="WB:WBGene00016415"/>
    <dbReference type="CTD" id="173891"/>
    <dbReference type="WormBase" id="C34F11.3c">
        <property type="protein sequence ID" value="CE44975"/>
        <property type="gene ID" value="WBGene00016415"/>
        <property type="gene designation" value="ampd-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NFLSGHY"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="PhylomeDB" id="H2KZ19"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016415">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ19">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD65833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C34F11.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ19"/>
        </source>
    </evidence>
    <sequence length="847" mass="97019" checksum="DC1A7AEF73A1E97D" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ21</accession>
    <name>H2KZ21_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_R144.3</name>
        <name evidence="3 5" type="ORF">R144.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD65867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254923.1">
        <property type="nucleotide sequence ID" value="NM_001267994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ21"/>
    <dbReference type="GeneID" id="187900"/>
    <dbReference type="KEGG" id="cel:CELE_R144.3"/>
    <dbReference type="AGR" id="WB:WBGene00020093"/>
    <dbReference type="CTD" id="187900"/>
    <dbReference type="WormBase" id="R144.3a">
        <property type="protein sequence ID" value="CE41692"/>
        <property type="gene ID" value="WBGene00020093"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846646at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020093">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ21">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD65867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="R144.3a"/>
        </source>
    </evidence>
    <sequence length="224" mass="25700" checksum="F38797887D8B71D3" modified="2012-03-21" version="1">MKSSSSWKNRPSSSSYRNPKFFGANPYQVSDLGACQSYGNQSHQPTVYDVTYIENLRKRFNSQQDERRSVRNNEKLGSETRHIHRRLKENTQPCDLSTLTCLVGCCGRSFERIEVLAFHVSYAHQDVMSAESNNLTCLLCGKKWTTRKIMHLSLAHREIGEEHNSQCMLQVESVIAPNAPKARRLVKARMAYDDNRPPGDPKYDGLDPFLESDNPEDDEYTYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ22</accession>
    <name>H2KZ22_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">wip-1</name>
        <name evidence="3" type="ORF">CELE_R144.4</name>
        <name evidence="5" type="ORF">R144.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD65872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741123.2">
        <property type="nucleotide sequence ID" value="NM_171863.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ22"/>
    <dbReference type="SMR" id="H2KZ22"/>
    <dbReference type="PeptideAtlas" id="H2KZ22"/>
    <dbReference type="GeneID" id="175681"/>
    <dbReference type="AGR" id="WB:WBGene00020094"/>
    <dbReference type="CTD" id="175681"/>
    <dbReference type="WormBase" id="R144.4a">
        <property type="protein sequence ID" value="CE34587"/>
        <property type="gene ID" value="WBGene00020094"/>
        <property type="gene designation" value="wip-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769946_0_0_1"/>
    <dbReference type="OrthoDB" id="5877983at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020094">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ22">
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    </dbReference>
    <dbReference type="GO" id="GO:0003779">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010172">
        <property type="term" value="P:embryonic body morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd22064">
        <property type="entry name" value="WH2_WAS_WASL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD65872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="R144.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ22"/>
        </source>
    </evidence>
    <sequence length="360" mass="36448" checksum="1F741336B6136033" modified="2012-03-21" version="1">MPPPPPPPPPPPPPPPPAASAPPPSSNARNALLGDIHKGLKLKKTVTNDRSAPSVGKVVGSSGSSSNGNSGNGNGPAAKPPQMSGGLGGLFANGMPMKPSENKIRRATTSIGPPPTASSAPPVPPPAPVPAVEGKKPSIVSSSSFSHHGATSSAPPPPPPPPPVSVPSSKPTPPPPPPAQQKPSSDREQFRTMRPLRPANDVKPTMYRRSGSSEDIPQATSATRLARPLAPPPARPAAPPPPVPTPSIAQMSSRFQSPAISRTLDDAPPPPPRIASKTSVAPTSSRAPLPPSSSFAPSISASPAPAPPPPPPQAASPYPGMKSTATVSANVPFHPLNRFHFLPLSQLPPPPKVSSGSIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ25</accession>
    <name>H2KZ25_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TAR DNA-binding protein 43 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="ORF">C27H5.2</name>
        <name evidence="4" type="ORF">CELE_C27H5.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD65886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_495485.1">
        <property type="nucleotide sequence ID" value="NM_063084.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ25"/>
    <dbReference type="SMR" id="H2KZ25"/>
    <dbReference type="PeptideAtlas" id="H2KZ25"/>
    <dbReference type="GeneID" id="174176"/>
    <dbReference type="AGR" id="WB:WBGene00016172"/>
    <dbReference type="CTD" id="174176"/>
    <dbReference type="WormBase" id="C27H5.2b">
        <property type="protein sequence ID" value="CE29191"/>
        <property type="gene ID" value="WBGene00016172"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016172">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ25">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TAR DNA-binding protein 43 N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD65886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C27H5.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ25"/>
        </source>
    </evidence>
    <sequence length="459" mass="52410" checksum="FF51E226197829E1" modified="2012-03-21" version="1">MSSITGLQVKSLRIGVEPVEVELDEDAGILWTSLQTAFPGCSGMYYREIGDSCKKSVKFDGKKFMAPGGAWNDREYFVTLSQRCHTAAGNSGHTASYSDATKQFEKSVQAVQKMMLASGMKIDMSHLTKKRQHTSSRETASSTSSSTVTPDPIQAIEERSQMLKTAGRELSPLEQQFLDLCRISTAKDQIIDANRQEITKMNETLRILEKNLKETETNLSEANAMVDCKQQELEMVSEALKRLEESRHTISELNRKSGNLEENVTELQMKLMNVEEENHGLKAQLETSHNRIKEMSDTISMLTSSKDILSKELDQLRPFADAAGIEDYENIPTFIHAIQENKELRKTNENMKLQSEETKDNHKQMQSIHTEVFEENAKLRNRNEDLERRFAHVDDELACVNENWAKELKEKQQDWDKVKYAAESEVLSLREQLVHLQSILESATREAAENARRNVIWDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ26</accession>
    <name>H2KZ26_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TAR DNA-binding protein 43 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="ORF">C27H5.2</name>
        <name evidence="4" type="ORF">CELE_C27H5.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD65887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_872042.1">
        <property type="nucleotide sequence ID" value="NM_182242.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ26"/>
    <dbReference type="SMR" id="H2KZ26"/>
    <dbReference type="GeneID" id="174176"/>
    <dbReference type="AGR" id="WB:WBGene00016172"/>
    <dbReference type="CTD" id="174176"/>
    <dbReference type="WormBase" id="C27H5.2c">
        <property type="protein sequence ID" value="CE32150"/>
        <property type="gene ID" value="WBGene00016172"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016172">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ26">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TAR DNA-binding protein 43 N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD65887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C27H5.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ26"/>
        </source>
    </evidence>
    <sequence length="491" mass="55960" checksum="7425E57D58475671" modified="2012-03-21" version="1">MSSITGLQVKSLRIGVEPVEVELDEDAGILWTSLQTAFPGCSGMYYREIGDSCKKSVKFDGKKFMAPGGAWNDREYFVTLSQRCHTAAGNSGHTASYSDATKQFEKSVQAVQKMMLASGMKIDMSHLTKKRQHTSSRETASSTSSSTVTPDPIQAIEERSQMLKTAGRELSPLEQQFLDLCRISTAKDQIIDANRQEITKMNETLRILEKNLKETETNLSEANAMVDCKQQELEMVSEALKRLEESRHTISELNRKSGNLEENVTELQMKLMNVEEENHGLKAQLETSHNRIKEMSDTISMLTSSKDILSKELDQLRPFADAAGIEDYENIPTFIHAIQENKELRKTNENMKLQSEETKDNHKQMQSIHTEVFEENAKLRNRNEDLERRFAHVDDELACVNENWAKELKEKQQDWDKVKYAAESEVLSLREQLVHLQSILESATREAAENARRVSELEHERHEVRRLSDAMHIKAQVSGSPVHRLSSSIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ31</accession>
    <name>H2KZ31_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enhancer of polycomb-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F13H8.1</name>
        <name evidence="2 4" type="ORF">F13H8.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD66042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022081.1">
        <property type="nucleotide sequence ID" value="NM_001026910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ31"/>
    <dbReference type="SMR" id="H2KZ31"/>
    <dbReference type="GeneID" id="184436"/>
    <dbReference type="KEGG" id="cel:CELE_F13H8.1"/>
    <dbReference type="AGR" id="WB:WBGene00017434"/>
    <dbReference type="CTD" id="184436"/>
    <dbReference type="WormBase" id="F13H8.1a">
        <property type="protein sequence ID" value="CE02635"/>
        <property type="gene ID" value="WBGene00017434"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1688315_0_0_1"/>
    <dbReference type="OrthoDB" id="5784965at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017434">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ31">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD66042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F13H8.1a"/>
        </source>
    </evidence>
    <sequence length="156" mass="17872" checksum="57639395BF80DD02" modified="2012-03-21" version="1">MSSSSGSSQPKRLGRRVFPNQQSDQIRRSQQFLHYVPPPEPPVDYTIRVPQEKDYKVIGDVFQRPSSVDYSKEETHLTSSSKGTPRLGGRRNTVEEVLDELDTVLFEASIPFDELKQKVERFNLTFKPYAPEITVDDLPEIPYSTGNLTKNISWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ34</accession>
    <name>H2KZ34_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein containing ALS2cr12 (ALS2CR12) signature</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">pals-23</name>
        <name evidence="3" type="ORF">C29F9.3</name>
        <name evidence="1" type="ORF">CELE_C29F9.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD66063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741063.1">
        <property type="nucleotide sequence ID" value="NM_171857.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ34"/>
    <dbReference type="SMR" id="H2KZ34"/>
    <dbReference type="GeneID" id="3565025"/>
    <dbReference type="AGR" id="WB:WBGene00016218"/>
    <dbReference type="CTD" id="3565025"/>
    <dbReference type="WormBase" id="C29F9.3c">
        <property type="protein sequence ID" value="CE30624"/>
        <property type="gene ID" value="WBGene00016218"/>
        <property type="gene designation" value="pals-23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016218">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ34">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD66063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C29F9.3c"/>
        </source>
    </evidence>
    <sequence length="286" mass="32934" checksum="A4E924AF51B71678" modified="2012-03-21" version="1">MSHELLFSKVKLKINQFIDDLKSTDSLWNEVRFDAHVDKISDCRTSIKELITNFLEKTNKNPGQFLTAQGNFATSILGILNDRFMIAIVTKDSLINNFRVQISSLNSVKQELTRKRERVGNAKPTIDKFQTILYWTNAIRTNMSIIGAIIYPMQRTVVKVNAKTLNSQFSAMQKNREILEQCHDKFKEFLNNDARVPPELFESFSRFQLNLAELMNNADFIAVCTHLSKAVEENNEEMILYYGKKVRALNQYFAKVTGDTEEELHQIVLENVQEPTSFLQVPSNPT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>O45228-2</accession>
    <name>PROD_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Proline dehydrogenase 1, mitochondrial</fullName>
            <ecNumber evidence="1">1.5.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Proline oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prdh-1</name>
        <name evidence="2" type="synonym">prodh</name>
        <name evidence="3" type="ORF">B0513.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Cell Rep." volume="17" first="2837" last="2844">
            <title>Proline Catabolism Modulates Innate Immunity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tang H."/>
                <person name="Pang S."/>
            </authorList>
            <dbReference type="PubMed" id="27974198"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.11.038"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O45228-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060478"/>
        </isoform>
        <isoform>
            <id>O45228-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001368485.1">
        <property type="nucleotide sequence ID" value="NM_001380524.1"/>
    </dbReference>
    <dbReference type="WormBase" id="B0513.5b">
        <property type="protein sequence ID" value="CE49937"/>
        <property type="gene ID" value="WBGene00007197"/>
        <property type="gene designation" value="prdh-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O43272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="27974198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="B0513.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="B0513.5b"/>
        </source>
    </evidence>
    <sequence length="515" mass="58496" checksum="B5644B68AB6C480F" modified="2005-05-10" version="2" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2025-10-08" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>O45613</accession>
    <name>O45613_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CELE_H09F14.1</name>
        <name evidence="11 13" type="ORF">H09F14.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB08739.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256231.1">
        <property type="nucleotide sequence ID" value="NM_001269302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O45613"/>
    <dbReference type="SMR" id="O45613"/>
    <dbReference type="GeneID" id="186709"/>
    <dbReference type="UCSC" id="H09F14.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010375"/>
    <dbReference type="CTD" id="186709"/>
    <dbReference type="WormBase" id="H09F14.1a">
        <property type="protein sequence ID" value="CE42007"/>
        <property type="gene ID" value="WBGene00010375"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="PhylomeDB" id="O45613"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010375">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O45613">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF100">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="25"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB08739.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="H09F14.1a"/>
        </source>
    </evidence>
    <sequence length="374" mass="42283" checksum="1747C9F7EDFE45DD" modified="2008-02-05" version="2">MEETGFQFDVYMYLLPLIVIFGLSGNVISLVTIFHSRLRRVNANIYLIVLTLADSIFLTGILLICFKVDWIAYEYCVGLEYVLMTASYISSWSTAALTIERYLAIAHPLSHMKYGHVDRAKVMLYWVPIPFVLQLFQFFSLEPATEERKCALKEANYQIIAQAVDTVLCYVVPCGIIVVLNILVALQVQKSQEHFMAETKKSNSRRTGGSSSSSGTWTRILWVMPLVFVVLNTPFYVIMMIEIVFQIIYQSPPSGDTRSELFVTVYNTAHYMYYMNTAIDVLVYAFSSANFRKTAVIAWKRILCPGYAERQKGKVLVTDQTSRISYRMTSERSTIRFPNTPSRANSPKLTASNAVSVPLLGTEIQGSSKESTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2025-10-08" version="168" xmlns="https://uniprot.org/uniprot">
    <accession>O45623</accession>
    <name>O45623_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase 7</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Deubiquitinating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin thioesterase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-specific-processing protease 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">math-33</name>
        <name evidence="16" type="ORF">CELE_H19N07.2</name>
        <name evidence="18" type="ORF">H19N07.2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB07396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T23103">
        <property type="entry name" value="T23103"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_505825.1">
        <property type="nucleotide sequence ID" value="NM_073424.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O45623"/>
    <dbReference type="SMR" id="O45623"/>
    <dbReference type="MEROPS" id="C19.A54"/>
    <dbReference type="GeneID" id="179538"/>
    <dbReference type="UCSC" id="H19N07.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010406"/>
    <dbReference type="CTD" id="179538"/>
    <dbReference type="WormBase" id="H19N07.2a">
        <property type="protein sequence ID" value="CE16182"/>
        <property type="gene ID" value="WBGene00010406"/>
        <property type="gene designation" value="math-33"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010406">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O45623">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031581">
        <property type="term" value="P:hemidesmosome assembly"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03772">
        <property type="entry name" value="MATH_HAUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000015">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000275">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000044">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00917">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="14">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="193"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAB07396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="H19N07.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="O45623"/>
        </source>
    </evidence>
    <sequence length="1133" mass="131356" checksum="6742C643285C6025" modified="1998-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2025-10-08" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>O45624</accession>
    <name>O45624_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase 7</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Deubiquitinating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin thioesterase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-specific-processing protease 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">math-33</name>
        <name evidence="16" type="ORF">CELE_H19N07.2</name>
        <name evidence="18" type="ORF">H19N07.2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB07397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T23104">
        <property type="entry name" value="T23104"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_505826.1">
        <property type="nucleotide sequence ID" value="NM_073425.8"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O45624"/>
    <dbReference type="SMR" id="O45624"/>
    <dbReference type="MEROPS" id="C19.A54"/>
    <dbReference type="GeneID" id="179538"/>
    <dbReference type="UCSC" id="H19N07.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010406"/>
    <dbReference type="CTD" id="179538"/>
    <dbReference type="WormBase" id="H19N07.2b">
        <property type="protein sequence ID" value="CE16183"/>
        <property type="gene ID" value="WBGene00010406"/>
        <property type="gene designation" value="math-33"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010406">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O45624">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031581">
        <property type="term" value="P:hemidesmosome assembly"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03772">
        <property type="entry name" value="MATH_HAUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000015">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000275">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000044">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00917">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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    <accession>P27639-2</accession>
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    <reference key="1">
        <citation type="journal article" date="1992" name="Nucleic Acids Res." volume="20" first="3783" last="3783">
            <title>Caenorhabditis cDNA encodes an eIF-4A-like protein.</title>
            <authorList>
                <person name="Roussell D.L."/>
                <person name="Bennett K.L."/>
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            <dbReference type="PubMed" id="1641346"/>
            <dbReference type="DOI" id="10.1093/nar/20.14.3783"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
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            <strain>Bristol N2</strain>
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    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
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        <event type="alternative splicing"/>
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            <id>P27639-1</id>
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        <isoform>
            <id>P27639-2</id>
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    <proteinExistence type="evidence at transcript level"/>
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    <accession>Q21054-2</accession>
    <name>CGT3_CAEEL</name>
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        <recommendedName>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference key="1">
        <citation type="journal article" date="1995" name="Lipids" volume="30" first="567" last="573">
            <title>The glycosylceramides of the nematode Caenorhabditis elegans contain an unusual, branched-chain sphingoid base.</title>
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                <person name="Chitwood D.J."/>
                <person name="Lusby W.R."/>
                <person name="Thompson M.J."/>
                <person name="Kochansky J.P."/>
                <person name="Howarth O.W."/>
            </authorList>
            <dbReference type="PubMed" id="7651085"/>
            <dbReference type="DOI" id="10.1007/bf02537032"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genomics" volume="89" first="392" last="401">
            <title>The frataxin-encoding operon of Caenorhabditis elegans shows complex structure and regulation.</title>
            <authorList>
                <person name="Vazquez-Manrique R.P."/>
                <person name="Gonzalez-Cabo P."/>
                <person name="Ortiz-Martin I."/>
                <person name="Ros S."/>
                <person name="Baylis H.A."/>
                <person name="Palau F."/>
            </authorList>
            <dbReference type="PubMed" id="17174523"/>
            <dbReference type="DOI" id="10.1016/j.ygeno.2006.10.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND D)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="J. Cell Sci." volume="122" first="822" last="833">
            <title>Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells.</title>
            <authorList>
                <person name="Marza E."/>
                <person name="Simonsen K.T."/>
                <person name="Faergeman N.J."/>
                <person name="Lesa G.M."/>
            </authorList>
            <dbReference type="PubMed" id="19240113"/>
            <dbReference type="DOI" id="10.1242/jcs.042754"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Glycobiology" volume="21" first="834" last="848">
            <title>Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division.</title>
            <authorList>
                <person name="Nomura K.H."/>
                <person name="Murata D."/>
                <person name="Hayashi Y."/>
                <person name="Dejima K."/>
                <person name="Mizuguchi S."/>
                <person name="Kage-Nakadai E."/>
                <person name="Gengyo-Ando K."/>
                <person name="Mitani S."/>
                <person name="Hirabayashi Y."/>
                <person name="Ito M."/>
                <person name="Nomura K."/>
            </authorList>
            <dbReference type="PubMed" id="21325339"/>
            <dbReference type="DOI" id="10.1093/glycob/cwr019"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="PLoS ONE" volume="10" first="e0130778" last="e0130778">
            <title>Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhu M."/>
                <person name="Wu G."/>
                <person name="Li Y.X."/>
                <person name="Stevens J.K."/>
                <person name="Fan C.X."/>
                <person name="Spang A."/>
                <person name="Dong M.Q."/>
            </authorList>
            <dbReference type="PubMed" id="26115433"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0130778"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2016" name="PLoS ONE" volume="11" first="e0163398" last="e0163398">
            <title>Correction: Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhu M."/>
                <person name="Wu G."/>
                <person name="Li Y.X."/>
                <person name="Stevens J.K."/>
                <person name="Fan C.X."/>
                <person name="Spang A."/>
                <person name="Dong M.Q."/>
            </authorList>
            <dbReference type="PubMed" id="27631731"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0163398"/>
        </citation>
        <scope>ERRATUM OF PUBMED:26115433</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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            <id>Q21054-4</id>
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            <sequence type="described" ref="VSP_045383"/>
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        <isoform>
            <id>Q21054-2</id>
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        <property type="gene designation" value="cgt-3"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="21325339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="19240113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="21325339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F59G1.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F59G1.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F59G1.1d"/>
        </source>
    </evidence>
    <sequence length="470" mass="52363" checksum="9D7F5A8FD65763F6" modified="2002-03-01" version="2">MEVAKAVATNLSTAANSTVLRTVASSTSSIIGAAAAAVAEAQPSASPSTSSSFLLLEVPFRHLLRLQPPPYFIAGTRRMAAQLDVTTLIAIVGFVFVFCLYLIHIIALSYSKYRLHHKVKEDSSLPGVSIIKPIVGKDNNLYENIESFFTTQYHKYELLFCFNSSDDEAVEVVKCLMKKYPKVDAKLFFGGETVGLNPKINNMMPAYRSALYPLILVSDSGIFMRSDGVLDMATTMMSHEKMALVTQTPYCKDREGFDAAFEQMYFGTSHGRIYLAGNCMDFVCSTGMSSMMKKEALDECGGISNFGGYLAEDYFFGRELANRGYKSAISSHPALQNSSSVSVSSFLDRICRWVKLRIAMLPHILLVEPLQDCFPSGLIMAFSLNHLVGLNIMPILILHTIYWFSMDYSLMNSMQNGKLSFSPLQFMLIWLLRELTAPFVFIKALLQPTIQWRNNVFHLAWGGQILPPKC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-03-06" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q21054-4</accession>
    <name>CGT3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform d of Ceramide glucosyltransferase 3</fullName>
            <shortName evidence="2 3">CGT-3</shortName>
            <ecNumber evidence="1">2.4.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cgt-3</name>
        <name evidence="4" type="ORF">F59G1.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Lipids" volume="30" first="567" last="573">
            <title>The glycosylceramides of the nematode Caenorhabditis elegans contain an unusual, branched-chain sphingoid base.</title>
            <authorList>
                <person name="Chitwood D.J."/>
                <person name="Lusby W.R."/>
                <person name="Thompson M.J."/>
                <person name="Kochansky J.P."/>
                <person name="Howarth O.W."/>
            </authorList>
            <dbReference type="PubMed" id="7651085"/>
            <dbReference type="DOI" id="10.1007/bf02537032"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genomics" volume="89" first="392" last="401">
            <title>The frataxin-encoding operon of Caenorhabditis elegans shows complex structure and regulation.</title>
            <authorList>
                <person name="Vazquez-Manrique R.P."/>
                <person name="Gonzalez-Cabo P."/>
                <person name="Ortiz-Martin I."/>
                <person name="Ros S."/>
                <person name="Baylis H.A."/>
                <person name="Palau F."/>
            </authorList>
            <dbReference type="PubMed" id="17174523"/>
            <dbReference type="DOI" id="10.1016/j.ygeno.2006.10.007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND D)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="J. Cell Sci." volume="122" first="822" last="833">
            <title>Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells.</title>
            <authorList>
                <person name="Marza E."/>
                <person name="Simonsen K.T."/>
                <person name="Faergeman N.J."/>
                <person name="Lesa G.M."/>
            </authorList>
            <dbReference type="PubMed" id="19240113"/>
            <dbReference type="DOI" id="10.1242/jcs.042754"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Glycobiology" volume="21" first="834" last="848">
            <title>Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division.</title>
            <authorList>
                <person name="Nomura K.H."/>
                <person name="Murata D."/>
                <person name="Hayashi Y."/>
                <person name="Dejima K."/>
                <person name="Mizuguchi S."/>
                <person name="Kage-Nakadai E."/>
                <person name="Gengyo-Ando K."/>
                <person name="Mitani S."/>
                <person name="Hirabayashi Y."/>
                <person name="Ito M."/>
                <person name="Nomura K."/>
            </authorList>
            <dbReference type="PubMed" id="21325339"/>
            <dbReference type="DOI" id="10.1093/glycob/cwr019"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="PLoS ONE" volume="10" first="e0130778" last="e0130778">
            <title>Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhu M."/>
                <person name="Wu G."/>
                <person name="Li Y.X."/>
                <person name="Stevens J.K."/>
                <person name="Fan C.X."/>
                <person name="Spang A."/>
                <person name="Dong M.Q."/>
            </authorList>
            <dbReference type="PubMed" id="26115433"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0130778"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2016" name="PLoS ONE" volume="11" first="e0163398" last="e0163398">
            <title>Correction: Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhu M."/>
                <person name="Wu G."/>
                <person name="Li Y.X."/>
                <person name="Stevens J.K."/>
                <person name="Fan C.X."/>
                <person name="Spang A."/>
                <person name="Dong M.Q."/>
            </authorList>
            <dbReference type="PubMed" id="27631731"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0163398"/>
        </citation>
        <scope>ERRATUM OF PUBMED:26115433</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21054-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_045383"/>
        </isoform>
        <isoform>
            <id>Q21054-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_045384"/>
        </isoform>
        <isoform>
            <id>Q21054-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001367789.1">
        <property type="nucleotide sequence ID" value="NM_001381440.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F59G1.1d">
        <property type="protein sequence ID" value="CE33409"/>
        <property type="gene ID" value="WBGene00019127"/>
        <property type="gene designation" value="cgt-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="21325339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="19240113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="21325339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F59G1.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F59G1.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F59G1.1d"/>
        </source>
    </evidence>
    <sequence length="392" mass="44354" checksum="FB9AA9A5AE413426" modified="2002-03-01" version="2">MAAQLDVTTLIAIVGFVFVFCLYLIHIIALSYSKYRLHHKVKEDSSLPGVSIIKPIVGKDNNLYENIESFFTTQYHKYELLFCFNSSDDEAVEVVKCLMKKYPKVDAKLFFGGETVGLNPKINNMMPAYRSALYPLILVSDSGIFMRSDGVLDMATTMMSHEKMALVTQTPYCKDREGFDAAFEQMYFGTSHGRIYLAGNCMDFVCSTGMSSMMKKEALDECGGISNFGGYLAEDYFFGRELANRGYKSAISSHPALQNSSSVSVSSFLDRICRWVKLRIAMLPHILLVEPLQDCFPSGLIMAFSLNHLVGLNIMPILILHTIYWFSMDYSLMNSMQNGKLSFSPLQFMLIWLLRELTAPFVFIKALLQPTIQWRNNVFHLAWGGQILPPKC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2026-01-28" version="182" xmlns="https://uniprot.org/uniprot">
    <accession>Q22875-2</accession>
    <name>SHOC2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Leucine-rich repeat protein soc-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Suppressor of Clr protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Suppressor of activated let-60 Ras protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">soc-2</name>
        <name type="synonym">sur-8</name>
        <name type="ORF">AC7.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Cell" volume="94" first="119" last="130">
            <title>SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.</title>
            <authorList>
                <person name="Sieburth D.S."/>
                <person name="Sun Q."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="9674433"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(00)81227-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH LET-60</scope>
        <scope>MUTAGENESIS OF CYS-233 AND GLU-430</scope>
        <source>
            <tissue>Vulva</tissue>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Proc. Natl. Acad. Sci. U.S.A." volume="95" first="6903" last="6908">
            <title>Soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.</title>
            <authorList>
                <person name="Selfors L.M."/>
                <person name="Schutzman J.L."/>
                <person name="Borland C.Z."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="9618511"/>
            <dbReference type="DOI" id="10.1073/pnas.95.12.6903"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS A AND B)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1999" name="Genes Dev." volume="13" first="2562" last="2569">
            <title>A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction.</title>
            <authorList>
                <person name="Sieburth D.S."/>
                <person name="Sundaram M."/>
                <person name="Howard R.M."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="10521400"/>
            <dbReference type="DOI" id="10.1101/gad.13.19.2562"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2001" name="Mol. Cell. Biol." volume="21" first="8104" last="8116">
            <title>The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.</title>
            <authorList>
                <person name="Schutzman J.L."/>
                <person name="Borland C.Z."/>
                <person name="Newman J.C."/>
                <person name="Robinson M.K."/>
                <person name="Kokel M."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="11689700"/>
            <dbReference type="DOI" id="10.1128/MCB.21.23.8104-8116.2001"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="EMBO J." volume="23" first="111" last="119">
            <title>Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase.</title>
            <authorList>
                <person name="Yoder J.H."/>
                <person name="Chong H."/>
                <person name="Guan K.-L."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="14685271"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600025"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="EMBO J." volume="24" first="2566" last="2578">
            <title>Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gottschalk A."/>
                <person name="Almedom R.B."/>
                <person name="Schedletzky T."/>
                <person name="Anderson S.D."/>
                <person name="Yates J.R. III"/>
                <person name="Schafer W.R."/>
            </authorList>
            <dbReference type="PubMed" id="15990870"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600741"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLU-430</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q22875-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q22875-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_038198"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741391.2">
        <property type="nucleotide sequence ID" value="NM_171332.5"/>
    </dbReference>
    <dbReference type="WormBase" id="AC7.2b">
        <property type="protein sequence ID" value="CE31275"/>
        <property type="gene ID" value="WBGene00004929"/>
        <property type="gene designation" value="soc-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="558" mass="62862" checksum="E48886B4ABD10412" modified="2001-12-01" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6V0</accession>
    <name>Q2L6V0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4968 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">B0261.6</name>
        <name evidence="1" type="ORF">CELE_B0261.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD61575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379560.1">
        <property type="nucleotide sequence ID" value="NM_001392286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6V0"/>
    <dbReference type="PeptideAtlas" id="Q2L6V0"/>
    <dbReference type="GeneID" id="172166"/>
    <dbReference type="UCSC" id="B0261.6b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00015094"/>
    <dbReference type="CTD" id="172166"/>
    <dbReference type="WormBase" id="B0261.6b">
        <property type="protein sequence ID" value="CE39549"/>
        <property type="gene ID" value="WBGene00015094"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1714929_0_0_1"/>
    <dbReference type="OrthoDB" id="5871241at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015094">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6V0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD61575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="B0261.6b"/>
        </source>
    </evidence>
    <sequence length="84" mass="9272" checksum="6E3054E48D0E033E" modified="2006-02-21" version="1">MSMASAEASVVAPDLTIYHGDRKQSYQLADKGKMVVINRKNGVIVYMLRCVDGRRVYIEKSSEGASLILTNQRGKVIKALAGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6V1</accession>
    <name>Q2L6V1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">mrpl-47</name>
        <name evidence="10" type="ORF">B0261.4</name>
        <name evidence="8" type="ORF">CELE_B0261.4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD61572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367333.1">
        <property type="nucleotide sequence ID" value="NM_001380146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6V1"/>
    <dbReference type="SMR" id="Q2L6V1"/>
    <dbReference type="PeptideAtlas" id="Q2L6V1"/>
    <dbReference type="GeneID" id="172164"/>
    <dbReference type="UCSC" id="B0261.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00015092"/>
    <dbReference type="CTD" id="172164"/>
    <dbReference type="WormBase" id="B0261.4b">
        <property type="protein sequence ID" value="CE39548"/>
        <property type="gene ID" value="WBGene00015092"/>
        <property type="gene designation" value="mrpl-47"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1291781_0_0_1"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015092">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6V1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD61572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="B0261.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q2L6V1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25601" checksum="BF6F0BFF95F5C129" modified="2006-02-21" version="1">MWRSLPSLVSSAVRSQNAVNTRFSSTMKQFFDDEANFGKAELRPKHRPGRSWTAEELRLKSNSDLHKLWYVCLKERNMLITMKKAHTSRARNMPNPERLDRVHETMDRIESVVHERNDAVFRLETGESAAPRKRTITSFAGFTYQKQATEHFAPPQLGQKEYETPYLDDDAYVMQKLWQEKEFMKNRDRLDDEKRRAARTEDMDRFKRGAPRVFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6V9</accession>
    <name>Q2L6V9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">tyra-3</name>
        <name evidence="14" type="ORF">CELE_M03F4.3</name>
        <name evidence="16" type="ORF">M03F4.3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD83481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041275.1">
        <property type="nucleotide sequence ID" value="NM_001047810.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6V9"/>
    <dbReference type="GeneID" id="187427"/>
    <dbReference type="UCSC" id="M03F4.3c.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006475"/>
    <dbReference type="CTD" id="187427"/>
    <dbReference type="WormBase" id="M03F4.3c">
        <property type="protein sequence ID" value="CE39602"/>
        <property type="gene ID" value="WBGene00006475"/>
        <property type="gene designation" value="tyra-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_11_1_1"/>
    <dbReference type="OrthoDB" id="6358729at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006475">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6V9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15061">
        <property type="entry name" value="7tmA_tyramine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000523">
        <property type="entry name" value="5-hydroxytryptamine receptor 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000311">
        <property type="entry name" value="TYRAmine receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="9"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD83481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="M03F4.3c"/>
        </source>
    </evidence>
    <sequence length="485" mass="55124" checksum="166A63E8E637FE76" modified="2006-02-21" version="1">MLILLTIFGNILVVLSVVVYKRMRTFTNILLTSLATADLLVGLIVMPMSLLDLLHNHRWPLGRFLCRMWATSDVLLCTASILNLCVISLDRYFAITSPLKYPRTRSRKMAAGLLTAVWAISFVVCSPPWVIPSWNLFIDNNNNTGSSEDFKCAYSPSVAYRIYSALGSFYLPLLVMLFVYFKIFRVASEREALMRQSVGTCRLSNRLTKTQQKNQRNNLRTASAPHSRTRVQVNHNCGRVNYSVRPVEYANRVENSLKPSHERFDSTDCEDSPPNGDSLEAGTTCNISMSLVTNSPPNGLQKEAKNSMERECHSLADIVNSADTPVRKNTEVGVAPSLSKRARQCNARLQPNNLLQKAHEHYQINGPGKAVRGSKEKMVYMRERKALKTIGIVVLGFIICWMPFFIMYLVEVFISDPVAESPIYRITSEFFLWLGYSNSVLNPIIYTMYNGDFRRCFRDLLSFGCVQHHRRTMSVKKLHQQSTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6W1</accession>
    <name>Q2L6W1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">rml-4</name>
        <name evidence="3" type="ORF">C01F1.3</name>
        <name evidence="1" type="ORF">CELE_C01F1.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD62407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040728.1">
        <property type="nucleotide sequence ID" value="NM_001047263.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6W1"/>
    <dbReference type="SMR" id="Q2L6W1"/>
    <dbReference type="PeptideAtlas" id="Q2L6W1"/>
    <dbReference type="GeneID" id="173762"/>
    <dbReference type="UCSC" id="C01F1.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00015298"/>
    <dbReference type="CTD" id="173762"/>
    <dbReference type="WormBase" id="C01F1.3b">
        <property type="protein sequence ID" value="CE39553"/>
        <property type="gene ID" value="WBGene00015298"/>
        <property type="gene designation" value="rml-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026813_1_0_1"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015298">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6W1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD62407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C01F1.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="Q2L6W1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16606" checksum="7B7C7E0F0CD9BF84" modified="2006-02-21" version="1">MNYFNQNGWENLNVRITLPLSLDLEQPRNLLSKIIKYKELFDIPVSLTILPDCMNAMCNLMEQRSGGTLNLVNPEPISLYEVVKIYKEIVDETVNPTSIGVETERAQHLLATKGNCALDTEKLQSLAPVLSAKQSLIKHFSEMTSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6W3</accession>
    <name>Q2L6W3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_K09C4.1</name>
        <name evidence="3 5" type="ORF">K09C4.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041270.1">
        <property type="nucleotide sequence ID" value="NM_001047805.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6W3"/>
    <dbReference type="SMR" id="Q2L6W3"/>
    <dbReference type="GeneID" id="180621"/>
    <dbReference type="UCSC" id="K09C4.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019547"/>
    <dbReference type="CTD" id="180621"/>
    <dbReference type="WormBase" id="K09C4.1b">
        <property type="protein sequence ID" value="CE39595"/>
        <property type="gene ID" value="WBGene00019547"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042713_0_0_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019547">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6W3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD69242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K09C4.1b"/>
        </source>
    </evidence>
    <sequence length="113" mass="12898" checksum="77AE4151057ECB43" modified="2006-02-21" version="1">MLFGSMAVNSPIVALYPIVNSIFPPIFFVPFVISQMIFGIYLYRHMPETRGRAVYDIIESLDRNVASRTASVTDENTPLFKDQTENRDGKWNSLLNTPRTRALTFEENSHSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6W4</accession>
    <name>Q2L6W4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_K03A1.4</name>
        <name evidence="2 4" type="ORF">K03A1.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD72540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041264.1">
        <property type="nucleotide sequence ID" value="NM_001047799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6W4"/>
    <dbReference type="SMR" id="Q2L6W4"/>
    <dbReference type="GeneID" id="186916"/>
    <dbReference type="UCSC" id="K03A1.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019352"/>
    <dbReference type="CTD" id="186916"/>
    <dbReference type="WormBase" id="K03A1.4b">
        <property type="protein sequence ID" value="CE39580"/>
        <property type="gene ID" value="WBGene00019352"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3242675_0_0_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019352">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6W4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD72540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K03A1.4b"/>
        </source>
    </evidence>
    <sequence length="43" mass="4859" checksum="3A370E7503C185FF" modified="2006-02-21" version="1">MEMLSIVRELSLQASFPRQVVEQLFNEADIDGDGKISFEGMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6X4</accession>
    <name>Q2L6X4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_PDB1.1</name>
        <name evidence="8 10" type="ORF">PDB1.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041278.1">
        <property type="nucleotide sequence ID" value="NM_001047813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6X4"/>
    <dbReference type="SMR" id="Q2L6X4"/>
    <dbReference type="GeneID" id="181016"/>
    <dbReference type="UCSC" id="PDB1.1b.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019803"/>
    <dbReference type="CTD" id="181016"/>
    <dbReference type="WormBase" id="PDB1.1c">
        <property type="protein sequence ID" value="CE39604"/>
        <property type="gene ID" value="WBGene00019803"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_2_1_1"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019803">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6X4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF8">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="7">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD69000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="PDB1.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q2L6X4"/>
        </source>
    </evidence>
    <sequence length="111" mass="13003" checksum="FBFBC337A247D781" modified="2006-02-21" version="1">MVSGFIIVTWFLTIREHIPYLIGRRADQEFINRITNISINHDQRIKALDTVHVYHFGEKFLVEVHAVFDEPAPLQMAHDVAESLQVKLEKLPFVERAFVHCDYKFDGDEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6X5</accession>
    <name>Q2L6X5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CELE_PDB1.1</name>
        <name evidence="11 13" type="ORF">PDB1.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD68999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041277.1">
        <property type="nucleotide sequence ID" value="NM_001047812.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6X5"/>
    <dbReference type="SMR" id="Q2L6X5"/>
    <dbReference type="GeneID" id="181016"/>
    <dbReference type="UCSC" id="PDB1.1b.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019803"/>
    <dbReference type="CTD" id="181016"/>
    <dbReference type="WormBase" id="PDB1.1b">
        <property type="protein sequence ID" value="CE39603"/>
        <property type="gene ID" value="WBGene00019803"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_2_1_1"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019803">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6X5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF8">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="29"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="222"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD68999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="PDB1.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q2L6X5"/>
        </source>
    </evidence>
    <sequence length="306" mass="34838" checksum="2B1E404C94D2A57F" modified="2006-02-21" version="1">MQTLTEEESDKAAEKEKRDLVWDSRITTLTIILNVSLIIAKSIVAYFSGSLAILASVVDSFMDITSGVVVWYACYKIEKMNKEQYPVGMRKLEPLTVVIVGMIMLFANFIVLERATVQTIEDKLDPRVDLTTLIVLCTGTATKFCLFMICRVRKSAACLVLAIDQRNDCLTNIVALLGAWIGQNWWKYADPLGAFMVSGFIIVTWFLTIREHIPYLIGRRADQEFINRITNISINHDQRIKALDTVHVYHFGEKFLVEVHAVFDEPAPLQMAHDVAESLQVKLEKLPFVERAFVHCDYKFDGDEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6X7</accession>
    <name>Q2L6X7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">mct-4</name>
        <name evidence="5" type="ORF">CELE_K05B2.5</name>
        <name evidence="7" type="ORF">K05B2.5</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD72669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370787.1">
        <property type="nucleotide sequence ID" value="NM_001383567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6X7"/>
    <dbReference type="PeptideAtlas" id="Q2L6X7"/>
    <dbReference type="GeneID" id="180766"/>
    <dbReference type="UCSC" id="K05B2.5a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003986"/>
    <dbReference type="CTD" id="180766"/>
    <dbReference type="WormBase" id="K05B2.5c">
        <property type="protein sequence ID" value="CE39590"/>
        <property type="gene ID" value="WBGene00003986"/>
        <property type="gene designation" value="mct-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003986">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6X7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000481">
        <property type="entry name" value="MonoCarboxylate Transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF286">
        <property type="entry name" value="GH22266P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="512"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD72669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="K05B2.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q2L6X7"/>
        </source>
    </evidence>
    <sequence length="710" mass="77209" checksum="66ADA12CA47635AB" modified="2006-02-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q4TTA9</accession>
    <name>Q4TTA9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">praf-3</name>
        <name evidence="6" type="ORF">CELE_D2096.2</name>
        <name evidence="8" type="ORF">D2096.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
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            <begin position="12"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="EMBL" id="CCD68507.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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            <dbReference type="WormBase" id="D2096.2b"/>
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</entry>
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    <accession>Q565A2</accession>
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        <property type="gene ID" value="WBGene00007042"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PeptideAtlas" id="Q565A2"/>
        </source>
    </evidence>
    <sequence length="513" mass="57786" checksum="0949D34E6AAFA23E" modified="2005-05-10" version="1"> </sequence>
</entry>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
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        <property type="gene designation" value="szy-20"/>
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        <property type="component" value="Chromosome II"/>
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        <location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C18E9.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q565A8"/>
        </source>
    </evidence>
    <sequence length="560" mass="64018" checksum="B0630D2B4C616EBB" modified="2007-06-26" version="2"> </sequence>
</entry>
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    <accession>Q565B4</accession>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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    </dbReference>
    <dbReference type="RefSeq" id="NP_001370207.1">
        <property type="nucleotide sequence ID" value="NM_001383161.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q565B4"/>
    <dbReference type="SMR" id="Q565B4"/>
    <dbReference type="GeneID" id="177761"/>
    <dbReference type="UCSC" id="T20D3.3a.1">
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    <dbReference type="AGR" id="WB:WBGene00011857"/>
    <dbReference type="CTD" id="177761"/>
    <dbReference type="WormBase" id="T20D3.3b">
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        <property type="gene ID" value="WBGene00011857"/>
        <property type="gene designation" value="coa-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841606at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011857">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q565B4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAI79220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T20D3.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q565B4"/>
        </source>
    </evidence>
    <sequence length="260" mass="30533" checksum="26B554E159673825" modified="2005-05-10" version="1">MDFLNDFDPSDDENNCKHQEKPTYLPFKPNFHEKYWYRNALKENQTATAITEIDLFRVADCYHNGDFECAENLSSPETSISLQFLSYYESILVDFGDQIQFLRTKAFLLSKLPFTSNYQKEFKNTMALLCQLCGSFENWQLFEIGSKYFTKLEMFGLKLKMKKVLKYEIDHSKGFIQEKLKKRLEKITKELNELEGELESNIIESIHSSINSHKDTTTVESTPNSEFRAHESRSKNKLIPVSDQPATIEDFFHRFPFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2025-10-08" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q565B7</accession>
    <name>Q565B7_CAEEL</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">slo-2</name>
        <name evidence="14" type="ORF">CELE_F08B12.3</name>
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    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
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        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAI79159.1"/>
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    <dbReference type="UCSC" id="F08B12.3b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
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        <property type="gene designation" value="slo-2"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
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    </dbReference>
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        <property type="entry name" value="SLOwpoke potassium channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="13">
        <location>
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            <end position="434"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAI79159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="F08B12.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="Q565B7"/>
        </source>
    </evidence>
    <sequence length="1086" mass="124838" checksum="95B237ADCDE73A37" modified="2005-05-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q565D1</accession>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
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    </dbReference>
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    <dbReference type="UCSC" id="F49E2.5j.1">
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    </dbReference>
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    <dbReference type="WormBase" id="F49E2.5j">
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        <property type="gene ID" value="WBGene00009888"/>
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    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
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    </dbReference>
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    </dbReference>
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            <end position="28"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="82"/>
            <end position="165"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="336"/>
            <end position="345"/>
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            <dbReference type="PROSITE" id="PS50086"/>
        </source>
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            <dbReference type="EMBL" id="CAE45741.2"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
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            <dbReference type="PeptideAtlas" id="Q7K711"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112860" checksum="5A929913E439FCB6" modified="2012-03-21" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q7K712</accession>
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                <person name="Waterston R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="gene ID" value="WBGene00012912"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5814315at2759"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012912">
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    </dbReference>
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    </dbReference>
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            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
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            <end position="245"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="105"/>
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            <begin position="145"/>
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        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB60365.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="Y46G5A.22b"/>
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</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z291</accession>
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        <submittedName>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="CCD67343.2"/>
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        <property type="organism name" value="c. elegans"/>
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    <dbReference type="WormBase" id="F08C6.1c">
        <property type="protein sequence ID" value="CE47865"/>
        <property type="gene ID" value="WBGene00000083"/>
        <property type="gene designation" value="adt-2"/>
    </dbReference>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs adt-2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004295119" evidence="11">
        <location>
            <begin position="18"/>
            <end position="975"/>
        </location>
    </feature>
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        <location>
            <begin position="211"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD67343.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F08C6.1c"/>
        </source>
    </evidence>
    <sequence length="975" mass="108148" checksum="3FB30108D307B3A4" modified="2013-02-06" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z292</accession>
    <name>Q7Z292_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">A disintegrin and metalloproteinase with thrombospondin motifs adt-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">adt-2</name>
        <name evidence="1" type="ORF">CELE_F08C6.1</name>
        <name evidence="3" type="ORF">F08C6.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367660.1">
        <property type="nucleotide sequence ID" value="NM_001381025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z292"/>
    <dbReference type="SMR" id="Q7Z292"/>
    <dbReference type="PeptideAtlas" id="Q7Z292"/>
    <dbReference type="GeneID" id="181022"/>
    <dbReference type="UCSC" id="F08C6.1a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000083"/>
    <dbReference type="CTD" id="181022"/>
    <dbReference type="WormBase" id="F08C6.1b">
        <property type="protein sequence ID" value="CE33991"/>
        <property type="gene ID" value="WBGene00000083"/>
        <property type="gene designation" value="adt-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_296160_0_0_1"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000083">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z292">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000128">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs adt-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000132">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs adt-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD67342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F08C6.1b"/>
        </source>
    </evidence>
    <sequence length="125" mass="13940" checksum="C572F021DE87A468" modified="2003-10-01" version="1">MGASSEQQFCNEQACASSSANDWGTWSGWSQCSVSCGAGVKRRTRTCRTGNCPGNYKESAICNDRDCENKNAAWGGWGYWSSCSETCGDGVRKRVRKCYGSGNCDGQQYEKQYCNLRVCDFRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z297</accession>
    <name>Q7Z297_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nssp-79</name>
        <name evidence="2" type="ORF">CELE_F41B4.2</name>
        <name evidence="4" type="ORF">F41B4.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024646.1">
        <property type="nucleotide sequence ID" value="NM_001029475.8"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z297"/>
    <dbReference type="GeneID" id="180953"/>
    <dbReference type="UCSC" id="F41B4.2b.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018258"/>
    <dbReference type="CTD" id="180953"/>
    <dbReference type="WormBase" id="F41B4.2b">
        <property type="protein sequence ID" value="CE07212"/>
        <property type="gene ID" value="WBGene00018258"/>
        <property type="gene designation" value="nssp-79"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116890_0_0_1"/>
    <dbReference type="OrthoDB" id="10275198at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018258">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z297">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035291">
        <property type="entry name" value="DUF5354"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31712">
        <property type="entry name" value="DIETARY RESTRICTION OVER EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31712:SF1">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17305">
        <property type="entry name" value="DUF5354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004295566" evidence="1">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD67905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F41B4.2b"/>
        </source>
    </evidence>
    <sequence length="156" mass="17287" checksum="7E1F3840A488BDDC" modified="2003-10-01" version="1">MIAFSKLAGVMSVIALANSLAPAENAVQDAKNQEDKLLRCWEKVDVNNPGSGYVLSEPIFTLCSHMIDPKDNSKFHVNGVDENSDDYSPVLKMFADTIDDYAVLTVCLQEAFAFHGPTRNAQISLRCLCKREGCNAPRSLTEFLEFNKKPMPAFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z299</accession>
    <name>Q7Z299_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diacylglycerol kinase</fullName>
            <shortName evidence="7">DAG kinase</shortName>
            <ecNumber evidence="7">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">dgk-2</name>
        <name evidence="9" type="ORF">CELE_F46H6.2</name>
        <name evidence="11" type="ORF">F46H6.2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="7"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379634.1">
        <property type="nucleotide sequence ID" value="NM_001392762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z299"/>
    <dbReference type="SMR" id="Q7Z299"/>
    <dbReference type="GeneID" id="180720"/>
    <dbReference type="UCSC" id="F46H6.2c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000959"/>
    <dbReference type="CTD" id="180720"/>
    <dbReference type="WormBase" id="F46H6.2c">
        <property type="protein sequence ID" value="CE34029"/>
        <property type="gene ID" value="WBGene00000959"/>
        <property type="gene designation" value="dgk-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003770_3_1_1"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000959">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z299">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000019">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000039">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF118">
        <property type="entry name" value="DIACYLGLYCEROL KINASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="8">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD63478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F46H6.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="Q7Z299"/>
        </source>
    </evidence>
    <sequence length="351" mass="39007" checksum="CBEB0B9835348A9B" modified="2003-10-01" version="1">MAVIDKIEIPVDIEKWRPIMVIVNPKSGSGAGKQLLRNFRAHLHPAQVVDVLKSNIAASLRWIDEHPNVDVRILIAGGDGTICSALDQIDTLSRRIPVAVLPLGTGNDLSRLLKWGKKCDGDIDVIKLMEDIQEAEVTLVDRWTIDAESQKKLGVRLQSNKTLSMTNYVSVGVDACVTLGMQNTRESIPRAMSSRLLNKFLFFTFGTKDVFERVCKGLNERIDLYLDDVHVNLPDIEGLIFLNIPYWGAGVKPWATYNDSHRQECDDEMIEVFAVTSSFHIAQMQIGLASPLCIGQAKHAKLVFKGNHSFPMQSDGEAWVNSAGTVLISHKCKTAMLRKAEKQTTGCGMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q86DM0</accession>
    <name>Q86DM0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y110A2AL.4</name>
        <name evidence="2 4" type="ORF">Y110A2AL.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD72974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_872032.1">
        <property type="nucleotide sequence ID" value="NM_182232.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86DM0"/>
    <dbReference type="SMR" id="Q86DM0"/>
    <dbReference type="GeneID" id="173630"/>
    <dbReference type="UCSC" id="Y110A2AL.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022441"/>
    <dbReference type="CTD" id="173630"/>
    <dbReference type="WormBase" id="Y110A2AL.4b">
        <property type="protein sequence ID" value="CE33473"/>
        <property type="gene ID" value="WBGene00022441"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5823236at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022441">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86DM0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004300664" evidence="1">
        <location>
            <begin position="18"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD72974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y110A2AL.4b"/>
        </source>
    </evidence>
    <sequence length="163" mass="17794" checksum="4476C7014AACA693" modified="2003-06-01" version="1">MIFRPLLLIFLAVNSDAQLLPPVKNILQNHLDIFQKAVDAGDKATMSKMIPLNHISDETLDKFIKAHKSMKMTAKSATFIGTGNTQSGISGVVEYARGGRTILLEVVVEKSPSSPSAYKFASIRTPPVPSQRRSFPTCMLGLVACYLHLIDVLPGSAEEILVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q95XP9-2</accession>
    <name>ZWILC_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Protein zwilch homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">zwl-1</name>
        <name type="ORF">Y39G10AR.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Genes Dev." volume="22" first="2385" last="2399">
            <title>A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.</title>
            <authorList>
                <person name="Gassmann R."/>
                <person name="Essex A."/>
                <person name="Hu J.-S."/>
                <person name="Maddox P.S."/>
                <person name="Motegi F."/>
                <person name="Sugimoto A."/>
                <person name="O'Rourke S.M."/>
                <person name="Bowerman B."/>
                <person name="McLeod I."/>
                <person name="Yates J.R. III"/>
                <person name="Oegema K."/>
                <person name="Cheeseman I.M."/>
                <person name="Desai A."/>
            </authorList>
            <dbReference type="PubMed" id="18765790"/>
            <dbReference type="DOI" id="10.1101/gad.1687508"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN RZZ COMPLEX</scope>
        <scope>INTERACTION WITH SPDL-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="1252" last="1267">
            <title>Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches.</title>
            <authorList>
                <person name="Essex A."/>
                <person name="Dammermann A."/>
                <person name="Lewellyn L."/>
                <person name="Oegema K."/>
                <person name="Desai A."/>
            </authorList>
            <dbReference type="PubMed" id="19109417"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-10-1047"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="Nat. Cell Biol." volume="12" first="894" last="901">
            <title>A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis.</title>
            <authorList>
                <person name="Dumont J."/>
                <person name="Oegema K."/>
                <person name="Desai A."/>
            </authorList>
            <dbReference type="PubMed" id="20729837"/>
            <dbReference type="DOI" id="10.1038/ncb2093"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Science" volume="342" first="1239" last="1242">
            <title>Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.</title>
            <authorList>
                <person name="Cheerambathur D.K."/>
                <person name="Gassmann R."/>
                <person name="Cook B."/>
                <person name="Oegema K."/>
                <person name="Desai A."/>
            </authorList>
            <dbReference type="PubMed" id="24231804"/>
            <dbReference type="DOI" id="10.1126/science.1246232"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH NDC-80</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95XP9-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95XP9-4</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_057650 VSP_057649"/>
        </isoform>
        <isoform>
            <id>Q95XP9-3</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_057649"/>
        </isoform>
        <isoform>
            <id>Q95XP9-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_057650"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001249151.1">
        <property type="nucleotide sequence ID" value="NM_001262222.4"/>
    </dbReference>
    <dbReference type="WormBase" id="Y39G10AR.2b">
        <property type="protein sequence ID" value="CE46826"/>
        <property type="gene ID" value="WBGene00021460"/>
        <property type="gene designation" value="zwl-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="Y39G10AR.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="Y39G10AR.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y39G10AR.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y39G10AR.2d"/>
        </source>
    </evidence>
    <sequence length="628" mass="70807" checksum="89A84E946BA44350" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q95XP9-3</accession>
    <name>ZWILC_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Protein zwilch homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">zwl-1</name>
        <name type="ORF">Y39G10AR.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Genes Dev." volume="22" first="2385" last="2399">
            <title>A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.</title>
            <authorList>
                <person name="Gassmann R."/>
                <person name="Essex A."/>
                <person name="Hu J.-S."/>
                <person name="Maddox P.S."/>
                <person name="Motegi F."/>
                <person name="Sugimoto A."/>
                <person name="O'Rourke S.M."/>
                <person name="Bowerman B."/>
                <person name="McLeod I."/>
                <person name="Yates J.R. III"/>
                <person name="Oegema K."/>
                <person name="Cheeseman I.M."/>
                <person name="Desai A."/>
            </authorList>
            <dbReference type="PubMed" id="18765790"/>
            <dbReference type="DOI" id="10.1101/gad.1687508"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN RZZ COMPLEX</scope>
        <scope>INTERACTION WITH SPDL-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="1252" last="1267">
            <title>Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches.</title>
            <authorList>
                <person name="Essex A."/>
                <person name="Dammermann A."/>
                <person name="Lewellyn L."/>
                <person name="Oegema K."/>
                <person name="Desai A."/>
            </authorList>
            <dbReference type="PubMed" id="19109417"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-10-1047"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="Nat. Cell Biol." volume="12" first="894" last="901">
            <title>A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis.</title>
            <authorList>
                <person name="Dumont J."/>
                <person name="Oegema K."/>
                <person name="Desai A."/>
            </authorList>
            <dbReference type="PubMed" id="20729837"/>
            <dbReference type="DOI" id="10.1038/ncb2093"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Science" volume="342" first="1239" last="1242">
            <title>Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.</title>
            <authorList>
                <person name="Cheerambathur D.K."/>
                <person name="Gassmann R."/>
                <person name="Cook B."/>
                <person name="Oegema K."/>
                <person name="Desai A."/>
            </authorList>
            <dbReference type="PubMed" id="24231804"/>
            <dbReference type="DOI" id="10.1126/science.1246232"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH NDC-80</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95XP9-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_057650"/>
        </isoform>
        <isoform>
            <id>Q95XP9-4</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_057650 VSP_057649"/>
        </isoform>
        <isoform>
            <id>Q95XP9-3</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_057649"/>
        </isoform>
        <isoform>
            <id>Q95XP9-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001293318.1">
        <property type="nucleotide sequence ID" value="NM_001306389.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y39G10AR.2c">
        <property type="protein sequence ID" value="CE49916"/>
        <property type="gene ID" value="WBGene00021460"/>
        <property type="gene designation" value="zwl-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="Y39G10AR.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="Y39G10AR.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y39G10AR.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y39G10AR.2d"/>
        </source>
    </evidence>
    <sequence length="309" mass="35226" checksum="3BDDB60F4FB8339D" modified="2001-12-01" version="1">MAPPANFDDLVQEMDALVEASSREDNVFVSNENFRGGDITDKVWNIVRKCNDVKQVTLLFRNFLQALAYGKIKSHAQERNKSHLASLIRISKSSEFKIPVLERLSTIDMMMEIGVESLRRRVIDIFSSQLLYPSDELEFILQTCENDLPAGNGAMNSAAISLLPITMALATANRIYELLNEKDHVILPDLTRRILQKYTASMIEKSRRGETETEYTFETTLPLLRMYKEGFMSKRPCIWTCENSNTVGANVQARVLTSLELQPSLEHINRLVNDSRPVWTATEEKPAMIKDLNADYTVVHTIFSYLPKM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q95XP9-4</accession>
    <name>ZWILC_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform d of Protein zwilch homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">zwl-1</name>
        <name type="ORF">Y39G10AR.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Genes Dev." volume="22" first="2385" last="2399">
            <title>A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.</title>
            <authorList>
                <person name="Gassmann R."/>
                <person name="Essex A."/>
                <person name="Hu J.-S."/>
                <person name="Maddox P.S."/>
                <person name="Motegi F."/>
                <person name="Sugimoto A."/>
                <person name="O'Rourke S.M."/>
                <person name="Bowerman B."/>
                <person name="McLeod I."/>
                <person name="Yates J.R. III"/>
                <person name="Oegema K."/>
                <person name="Cheeseman I.M."/>
                <person name="Desai A."/>
            </authorList>
            <dbReference type="PubMed" id="18765790"/>
            <dbReference type="DOI" id="10.1101/gad.1687508"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN RZZ COMPLEX</scope>
        <scope>INTERACTION WITH SPDL-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="1252" last="1267">
            <title>Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches.</title>
            <authorList>
                <person name="Essex A."/>
                <person name="Dammermann A."/>
                <person name="Lewellyn L."/>
                <person name="Oegema K."/>
                <person name="Desai A."/>
            </authorList>
            <dbReference type="PubMed" id="19109417"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-10-1047"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="Nat. Cell Biol." volume="12" first="894" last="901">
            <title>A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis.</title>
            <authorList>
                <person name="Dumont J."/>
                <person name="Oegema K."/>
                <person name="Desai A."/>
            </authorList>
            <dbReference type="PubMed" id="20729837"/>
            <dbReference type="DOI" id="10.1038/ncb2093"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Science" volume="342" first="1239" last="1242">
            <title>Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.</title>
            <authorList>
                <person name="Cheerambathur D.K."/>
                <person name="Gassmann R."/>
                <person name="Cook B."/>
                <person name="Oegema K."/>
                <person name="Desai A."/>
            </authorList>
            <dbReference type="PubMed" id="24231804"/>
            <dbReference type="DOI" id="10.1126/science.1246232"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH NDC-80</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95XP9-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95XP9-4</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_057650 VSP_057649"/>
        </isoform>
        <isoform>
            <id>Q95XP9-3</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_057649"/>
        </isoform>
        <isoform>
            <id>Q95XP9-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_057650"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001293319.1">
        <property type="nucleotide sequence ID" value="NM_001306390.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y39G10AR.2d">
        <property type="protein sequence ID" value="CE49848"/>
        <property type="gene ID" value="WBGene00021460"/>
        <property type="gene designation" value="zwl-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="Y39G10AR.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="Y39G10AR.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y39G10AR.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y39G10AR.2d"/>
        </source>
    </evidence>
    <sequence length="307" mass="34937" checksum="289B5F0A7111B62E" modified="2001-12-01" version="1">MAPPANFDDLVQEMDALVEASSREDNVFVSNEKGGDITDKVWNIVRKCNDVKQVTLLFRNFLQALAYGKIKSHAQERNKSHLASLIRISKSSEFKIPVLERLSTIDMMMEIGVESLRRRVIDIFSSQLLYPSDELEFILQTCENDLPAGNGAMNSAAISLLPITMALATANRIYELLNEKDHVILPDLTRRILQKYTASMIEKSRRGETETEYTFETTLPLLRMYKEGFMSKRPCIWTCENSNTVGANVQARVLTSLELQPSLEHINRLVNDSRPVWTATEEKPAMIKDLNADYTVVHTIFSYLPKM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2026-01-28" version="165" xmlns="https://uniprot.org/uniprot">
    <accession>Q9NB31-2</accession>
    <name>CST1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Serine/threonine-protein kinase cst-1</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>STE20-like kinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>STE20-like kinase MST</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>cMST</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName>Serine/threonine-protein kinase cst-1 37kDa subunit</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>Serine/threonine-protein kinase cst-1 18kDa subunit</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="2" type="primary">cst-1</name>
        <name evidence="2" type="ORF">F14H12.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="19276" last="19285">
            <title>MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.</title>
            <authorList>
                <person name="Lee K.-K."/>
                <person name="Ohyama T."/>
                <person name="Yajima N."/>
                <person name="Tsubuki S."/>
                <person name="Yonehara S."/>
            </authorList>
            <dbReference type="PubMed" id="11278283"/>
            <dbReference type="DOI" id="10.1074/jbc.M005109200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>PROTEOLYTIC PROCESSING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Cell" volume="125" first="987" last="1001">
            <title>A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.</title>
            <authorList>
                <person name="Lehtinen M.K."/>
                <person name="Yuan Z."/>
                <person name="Boag P.R."/>
                <person name="Yang Y."/>
                <person name="Villen J."/>
                <person name="Becker E.B.E."/>
                <person name="DiBacco S."/>
                <person name="de la Iglesia N."/>
                <person name="Gygi S.P."/>
                <person name="Blackwell T.K."/>
                <person name="Bonni A."/>
            </authorList>
            <dbReference type="PubMed" id="16751106"/>
            <dbReference type="DOI" id="10.1016/j.cell.2006.03.046"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Exp. Cell Res." volume="319" first="1" last="11">
            <title>Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1.</title>
            <authorList>
                <person name="Iwasa H."/>
                <person name="Kuroyanagi H."/>
                <person name="Maimaiti S."/>
                <person name="Ikeda M."/>
                <person name="Nakagawa K."/>
                <person name="Hata Y."/>
            </authorList>
            <dbReference type="PubMed" id="23103556"/>
            <dbReference type="DOI" id="10.1016/j.yexcr.2012.10.008"/>
        </citation>
        <scope>INTERACTION WITH RSF-1</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9NB31-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9NB31-2</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_020043"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="RefSeq" id="NP_508743.4">
        <property type="nucleotide sequence ID" value="NM_076342.5"/>
    </dbReference>
    <dbReference type="WormBase" id="F14H12.4a">
        <property type="protein sequence ID" value="CE39916"/>
        <property type="gene ID" value="WBGene00017472"/>
        <property type="gene designation" value="cst-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="F14H12.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F14H12.4b"/>
        </source>
    </evidence>
    <sequence length="495" mass="55458" checksum="A2664572E91D41DD" modified="2000-10-01" version="1">MPPSTDSSRRNSEEGSSDGFKLDSSALNKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFIKNAPGCDIMQLMIQDAQEKAILGQAPMAASSGNDATLLSEGMSTMIDGGESTLVQHKDNYVTAQSLRSQMESLRIGGEIPKSAYSSSKNGNSPRVQPPGHTASASDPSKNQPFAQDGTGPNFQLGTSESSYKDASYNMMNTEAEYENRFQRAVVDGDFEFLRNITLDELIRRKESLDSEMEEEIRELQRRYKTKRQPILDVIEIKKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>U4PE29</accession>
    <name>U4PE29_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">oac-51</name>
        <name evidence="4" type="ORF">CELE_W03B1.7</name>
        <name evidence="6" type="ORF">W03B1.7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294303.1">
        <property type="nucleotide sequence ID" value="NM_001307374.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PE29"/>
    <dbReference type="GeneID" id="189146"/>
    <dbReference type="KEGG" id="cel:CELE_W03B1.7"/>
    <dbReference type="AGR" id="WB:WBGene00020976"/>
    <dbReference type="CTD" id="189146"/>
    <dbReference type="WormBase" id="W03B1.7b">
        <property type="protein sequence ID" value="CE48730"/>
        <property type="gene ID" value="WBGene00020976"/>
        <property type="gene designation" value="oac-51"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_12_1_1"/>
    <dbReference type="OrthoDB" id="10061508at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020976">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PE29">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF127">
        <property type="entry name" value="ACYL_TRANSF_3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="14"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="3">
        <location>
            <begin position="422"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDH93005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="W03B1.7b"/>
        </source>
    </evidence>
    <sequence length="675" mass="77762" checksum="3456525C37CB3675" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4PE35</accession>
    <name>U4PE35_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome Oxidase Assembly subunits</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">coa-1</name>
        <name evidence="1" type="ORF">CELE_Y38C1AA.14</name>
        <name evidence="3" type="ORF">Y38C1AA.14</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93010.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343699.1">
        <property type="nucleotide sequence ID" value="NM_001356895.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PE35"/>
    <dbReference type="SMR" id="U4PE35"/>
    <dbReference type="PeptideAtlas" id="U4PE35"/>
    <dbReference type="GeneID" id="13191872"/>
    <dbReference type="KEGG" id="cel:CELE_Y38C1AA.14"/>
    <dbReference type="AGR" id="WB:WBGene00195063"/>
    <dbReference type="CTD" id="13191872"/>
    <dbReference type="WormBase" id="Y38C1AA.14b">
        <property type="protein sequence ID" value="CE52366"/>
        <property type="gene ID" value="WBGene00195063"/>
        <property type="gene designation" value="coa-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2887869_0_0_1"/>
    <dbReference type="OrthoDB" id="64291at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00195063">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PE35">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47148">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47148:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93010.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y38C1AA.14b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="U4PE35"/>
        </source>
    </evidence>
    <sequence length="122" mass="13692" checksum="D1C5978D329738CF" modified="2017-12-20" version="2">MGSTGLYLAQKSVQWKVRALPHYNESLKIVMEHPKALEAIGAPISIGSVELSDRLHNYVDKTTSRLRIPVTGVVDCGFMDVLAVRENDKTAFETAKVRLFLNDGVYTIYDTGRWSETETTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4PE42</accession>
    <name>U4PE42_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">tag-244</name>
        <name evidence="4" type="ORF">C34H4.3</name>
        <name evidence="2" type="ORF">CELE_C34H4.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294313.1">
        <property type="nucleotide sequence ID" value="NM_001307384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PE42"/>
    <dbReference type="GeneID" id="176962"/>
    <dbReference type="KEGG" id="cel:CELE_C34H4.3"/>
    <dbReference type="AGR" id="WB:WBGene00044073"/>
    <dbReference type="CTD" id="176962"/>
    <dbReference type="WormBase" id="C34H4.3b">
        <property type="protein sequence ID" value="CE49049"/>
        <property type="gene ID" value="WBGene00044073"/>
        <property type="gene designation" value="tag-244"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040349_1_0_1"/>
    <dbReference type="OrthoDB" id="5869629at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044073">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PE42">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005071">
        <property type="entry name" value="Glycoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21733">
        <property type="entry name" value="CUB_2 DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21733:SF3">
        <property type="entry name" value="EXTRACELLULAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03409">
        <property type="entry name" value="Glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004652807" evidence="1">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C34H4.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PE42"/>
        </source>
    </evidence>
    <sequence length="168" mass="18245" checksum="DF497B52A8534E54" modified="2013-12-11" version="1">MCRRTLYALAFLICSVYADPRIIWLYNYDSGSTQNIVPVENGAKLHVASNDNVTLLQNIKIDAGLGAVSLDQVRSIADFKVSSNQLIITSTLDPPTSATLTGFIYVTTAAQANDNTFSVTTVDDLKTLSITSGKSTSVVLNTQFTTTHIRPFNAPDKTTYVTNVQQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>U4PE47</accession>
    <name>U4PE47_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_K10H10.10</name>
        <name evidence="1 3" type="ORF">K10H10.10</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH93020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293546.1">
        <property type="nucleotide sequence ID" value="NM_001306617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PE47"/>
    <dbReference type="SMR" id="U4PE47"/>
    <dbReference type="GeneID" id="3565646"/>
    <dbReference type="AGR" id="WB:WBGene00010765"/>
    <dbReference type="CTD" id="3565646"/>
    <dbReference type="WormBase" id="K10H10.10b">
        <property type="protein sequence ID" value="CE49062"/>
        <property type="gene ID" value="WBGene00010765"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_897849_0_0_1"/>
    <dbReference type="OrthoDB" id="5788555at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010765">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PE47">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="K10H10.10b"/>
        </source>
    </evidence>
    <sequence length="207" mass="24671" checksum="77E60D0C75ADFA11" modified="2013-12-11" version="1">MTEPDEEIDGLTQQQIQDELRKIIQEELAKKTIQKTSPDDPACSNLRDEYDEVCFSTPPLAAFQETREFCLAFVKNCQNSLLTNVFTNVKNFKIDFSIYCKKHRERFRYVCPDPLRFQSFAENAVDFCVRYQERCPNEPLPAEPIQFHRKDEGHIYTREIEFWCTRTKRTAYNYCTEPDLLRVYKYAMFCGMYKYACIDVYKRVIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>U4PE54</accession>
    <name>U4PE54_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y94H6A.12</name>
        <name evidence="4 6" type="ORF">Y94H6A.12</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PE54"/>
    <dbReference type="SMR" id="U4PE54"/>
    <dbReference type="PeptideAtlas" id="U4PE54"/>
    <dbReference type="AGR" id="WB:WBGene00050885"/>
    <dbReference type="WormBase" id="Y94H6A.12b">
        <property type="protein sequence ID" value="CE48819"/>
        <property type="gene ID" value="WBGene00050885"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119261_1_1_1"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00050885">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PE54">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDH93025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y94H6A.12b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="U4PE54"/>
        </source>
    </evidence>
    <sequence length="60" mass="6820" checksum="B4DBEB47CE04A6E3" modified="2013-12-11" version="1">MHKVTLGVDSEEEIKKVADKLTARNVDHKVWIEDGFPVCIALKPYPKEEVKNALKGLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>U4PE60</accession>
    <name>U4PE60_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">kvs-5</name>
        <name evidence="18" type="ORF">CELE_Y55F3C.3</name>
        <name evidence="20" type="ORF">Y55F3C.3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294323.1">
        <property type="nucleotide sequence ID" value="NM_001307394.3"/>
    </dbReference>
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    <sequence length="529" mass="60161" checksum="AC144C3680675AD2" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDO41071.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C09G4.1b"/>
        </source>
    </evidence>
    <sequence length="372" mass="44313" checksum="6330C48B64BFAEE1" modified="2014-06-11" version="1">MEVYRWAMSYFWHEPYWLPRNVTWPEVPAKFVDLLVPIYLAIPLVIIRILWESTIGVTYLYFRTNAYASRKNITLLGCMWEHMTGGFASVSRAKKILECFWRFSYYTFAFLYGLYVMKNSSWLYDVKQCWIGYPFHPVPDTIWWYYMIETGFYYSLLIGSTFDVRRSDFWQLMVHHVITIFLLSSSWTINFVRVGTLILLSHDVSDVFLEGGKLVRYDAHNKNMTNFMFVLFFSSWVATRLIYYPFIVIRSAVTEAAALIQPDYILWDYQLSPPYAPRLIVFALILLFFLHIFWTFIILRIAYRTSTGGQAKDVRSDSDSDYDEEEMARRERTRLLKKKKNKVSPSTDDDDDEGEEEKNDRKARHRRAPRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>X5LPU4</accession>
    <name>X5LPU4_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">afd-1</name>
        <name evidence="4" type="ORF">CELE_W03F11.6</name>
        <name evidence="6" type="ORF">W03F11.6</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDO41091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293334.1">
        <property type="nucleotide sequence ID" value="NM_001306405.3"/>
    </dbReference>
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        <property type="gene ID" value="WBGene00021009"/>
        <property type="gene designation" value="afd-1"/>
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            <end position="410"/>
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            <end position="624"/>
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        <location>
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            <end position="805"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="882"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1227"/>
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        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="708"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="766"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDO41091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="W03F11.6k"/>
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    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="X5LPU4"/>
        </source>
    </evidence>
    <sequence length="1227" mass="134803" checksum="D35293D88E890D20" modified="2014-06-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>X5LPV0</accession>
    <name>X5LPV0_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Transcription termination factor Rho</fullName>
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        <name evidence="2 4" type="ORF">C28C12.1</name>
        <name evidence="2" type="ORF">CELE_C28C12.1</name>
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    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDO41096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001368456.1">
        <property type="nucleotide sequence ID" value="NM_001380368.1"/>
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    <dbReference type="AlphaFoldDB" id="X5LPV0"/>
    <dbReference type="GeneID" id="182976"/>
    <dbReference type="AGR" id="WB:WBGene00016177"/>
    <dbReference type="CTD" id="182976"/>
    <dbReference type="WormBase" id="C28C12.1c">
        <property type="protein sequence ID" value="CE49668"/>
        <property type="gene ID" value="WBGene00016177"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1367334_0_0_1"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="X5LPV0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO41096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C28C12.1c"/>
        </source>
    </evidence>
    <sequence length="81" mass="9218" checksum="7C52018097B5C0B0" modified="2014-06-11" version="1">MQVSKTKSARNNKQKSDVKESATPGEDDEKEKTKTEGANGKTDEEGTEKKEPTMTESRKEMLREDDTLRDTKSIGKRQKKE</sequence>
</entry>
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    <accession>X5LQ33</accession>
    <name>X5LQ33_CAEEL</name>
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        <submittedName>
            <fullName evidence="16">Ligand-Gated ion Channel</fullName>
        </submittedName>
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        <name evidence="16 18" type="primary">lgc-51</name>
        <name evidence="16" type="ORF">CELE_F12B6.3</name>
        <name evidence="18" type="ORF">F12B6.3</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="CDO41152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001306431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="X5LQ33"/>
    <dbReference type="SMR" id="X5LQ33"/>
    <dbReference type="GeneID" id="184377"/>
    <dbReference type="AGR" id="WB:WBGene00017399"/>
    <dbReference type="CTD" id="184377"/>
    <dbReference type="WormBase" id="F12B6.3b">
        <property type="protein sequence ID" value="CE49642"/>
        <property type="gene ID" value="WBGene00017399"/>
        <property type="gene designation" value="lgc-51"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="X5LQ33">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012745775" evidence="13">
        <location>
            <begin position="16"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="14">
        <location>
            <begin position="36"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="15">
        <location>
            <begin position="216"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="326"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDO41152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="F12B6.3b"/>
        </source>
    </evidence>
    <sequence length="424" mass="48327" checksum="678BB4E201D59A0F" modified="2014-06-11" version="1">MCLFHFLAVIVTTFAQDEGSFVEKCTKPRLTPAAILDVIMANYSRSLPGNPVGVQVEVTVQDVMELSVLSNSFTADIWFSSIWYDPRLAYSHLDNCRQNLSFDDRFEKLIWSPNVCIVNTKSAHVHRSPKPNVLLMLLPNGTIWLNYRIRVQSPCSMDLARFPIDTQYCQLVFESYSYNTASVSVNWMANPVTVLPEISLADFDLSRYRTSRHTELYVPTYISLFISWIAFCIDTKALPARIVLGVNSLMSLTFQFGNIIRSLPPVSYVKAIDLWMCTCVGFIFASLLELAFVAYQDKKLILKSGKSNAAISTLVSYLKHFEPYHDVSSPPPPAPLDEKKSMSRTTSTGTNRSRSELDGLDTKDLEEEIAEYRKLAYARKKWRLLDFGANVDRISFIVFPLTFAAFNVVYWTYYLQDVRISTWT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-30" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MCZ8-2</accession>
    <name>CNNM3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Metal transporter cnnm-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">CNNM family homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cnnm-3</name>
        <name evidence="3" type="ORF">C33D12.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006276" last="E1006276">
            <title>Mg2+ extrusion from intestinal epithelia by CNNM proteins is essential for gonadogenesis via AMPK-TORC1 signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ishii T."/>
                <person name="Funato Y."/>
                <person name="Hashizume O."/>
                <person name="Yamazaki D."/>
                <person name="Hirata Y."/>
                <person name="Nishiwaki K."/>
                <person name="Kono N."/>
                <person name="Arai H."/>
                <person name="Miki H."/>
            </authorList>
            <dbReference type="PubMed" id="27564576"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006276"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A131MCZ8-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A131MCZ8-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_058664 VSP_058663"/>
        </isoform>
        <isoform>
            <id>A0A131MCZ8-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_058662"/>
        </isoform>
        <isoform>
            <id>A0A131MCZ8-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_058662 VSP_058664 VSP_058663"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001370534.1">
        <property type="nucleotide sequence ID" value="NM_001383538.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C33D12.2b">
        <property type="protein sequence ID" value="CE04764"/>
        <property type="gene ID" value="WBGene00016343"/>
        <property type="gene designation" value="cnnm-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C33D12.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C33D12.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C33D12.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C33D12.2d"/>
        </source>
    </evidence>
    <sequence length="250" mass="28001" checksum="4957C3DDD62443FD" modified="2016-05-11" version="1" precursor="true">MSQIVNTAHAKCAINIQMLAVTIQVMSTCHKIFSSNYILPTILEKLIRKNCKKVETTQFSCLKEVGVVQPKPAVLFTKGEFSNKFIMILSGRAVVTIGKEEMRLEAGAWHSFGTEVLDAMAEAIERSLNQSTSRSTVSLNTEITNNSIGFIPDFDTVILYECVFCEITAADLLLAYNSSQIMQNNTKMQVVRSNSRISLIEEIPKDAVSTPIRNGSVKLRTVSEGETVHLLPKNMECHFNKQEKYEEEEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-30" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MCZ8-3</accession>
    <name>CNNM3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Metal transporter cnnm-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">CNNM family homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cnnm-3</name>
        <name evidence="3" type="ORF">C33D12.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006276" last="E1006276">
            <title>Mg2+ extrusion from intestinal epithelia by CNNM proteins is essential for gonadogenesis via AMPK-TORC1 signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ishii T."/>
                <person name="Funato Y."/>
                <person name="Hashizume O."/>
                <person name="Yamazaki D."/>
                <person name="Hirata Y."/>
                <person name="Nishiwaki K."/>
                <person name="Kono N."/>
                <person name="Arai H."/>
                <person name="Miki H."/>
            </authorList>
            <dbReference type="PubMed" id="27564576"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006276"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A131MCZ8-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A131MCZ8-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_058663 VSP_058664"/>
        </isoform>
        <isoform>
            <id>A0A131MCZ8-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_058662 VSP_058663 VSP_058664"/>
        </isoform>
        <isoform>
            <id>A0A131MCZ8-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_058662"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001370952.1">
        <property type="nucleotide sequence ID" value="NM_001383539.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C33D12.2c">
        <property type="protein sequence ID" value="CE51420"/>
        <property type="gene ID" value="WBGene00016343"/>
        <property type="gene designation" value="cnnm-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C33D12.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C33D12.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C33D12.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C33D12.2d"/>
        </source>
    </evidence>
    <sequence length="766" mass="85881" checksum="134B33359ADCF861" modified="2016-05-11" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1I6CMA0</accession>
    <name>A0A1I6CMA0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">grl-23</name>
        <name evidence="3" type="ORF">CELE_E02A10.2</name>
        <name evidence="5" type="ORF">E02A10.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SFQ94299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001334228.1">
        <property type="nucleotide sequence ID" value="NM_001347273.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1I6CMA0"/>
    <dbReference type="GeneID" id="183983"/>
    <dbReference type="AGR" id="WB:WBGene00001732"/>
    <dbReference type="CTD" id="183983"/>
    <dbReference type="WormBase" id="E02A10.2e">
        <property type="protein sequence ID" value="CE51794"/>
        <property type="gene ID" value="WBGene00001732"/>
        <property type="gene designation" value="grl-23"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865457at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1I6CMA0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009303877" evidence="2">
        <location>
            <begin position="18"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SFQ94299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="E02A10.2e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1I6CMA0"/>
        </source>
    </evidence>
    <sequence length="352" mass="34581" checksum="3242B969665C3E65" modified="2017-01-18" version="1">MRKSIIILLLGLSVATAFLFPSGGGGGGGGGCGGGCGGGGGCGGGGGCGGGCGGGGGGCGGGGGGCGGGGGCGGGCAPPPPPPACGGGCGGGGGGCGGGCGGGGGGGCGGGGGGGCGGGGGGCGGGGGGCGGGGGGCGGGGGGGCGGGGGGGCGGGCGRKKREAINVVGHDDLNKCNNEELRIILNENTKETVAESIKTLKEKVAGQDYIVVCNEKPAPFTAETDDFCSLQKENVHCTILRINHKEVAEKNEEDKKEEEPKKEEEKKEEVEKKEEDEKKDEEPKKEEEKKEEEQKEEVEKKEEEEKKDEEPKKEEEKKEEEEKKEDEVEEKSEKVEEKELEPKKDEEETKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1I6CMA3</accession>
    <name>A0A1I6CMA3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">grl-23</name>
        <name evidence="2" type="ORF">CELE_E02A10.2</name>
        <name evidence="4" type="ORF">E02A10.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SFQ94297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001334226.1">
        <property type="nucleotide sequence ID" value="NM_001347276.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1I6CMA3"/>
    <dbReference type="GeneID" id="183983"/>
    <dbReference type="AGR" id="WB:WBGene00001732"/>
    <dbReference type="CTD" id="183983"/>
    <dbReference type="WormBase" id="E02A10.2c">
        <property type="protein sequence ID" value="CE51814"/>
        <property type="gene ID" value="WBGene00001732"/>
        <property type="gene designation" value="grl-23"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865457at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1I6CMA3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009303874" evidence="1">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SFQ94297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="E02A10.2c"/>
        </source>
    </evidence>
    <sequence length="134" mass="10218" checksum="46FE2F4ADE46CE52" modified="2017-01-18" version="1">MRKSIIILLLGLSVATAFLFPSGGGGGGGGGCGGGCGGGGGCGGGGGCGGGCAPPPPPPACGGGCGGGGGGCGGGGGGCGGGGGCGGGGGGCGGGGGGCGGGGGCGGGCAPPPPPPACGGGCGGGGGGCGGGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1I6CMA4</accession>
    <name>A0A1I6CMA4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">grl-23</name>
        <name evidence="3" type="ORF">CELE_E02A10.2</name>
        <name evidence="5" type="ORF">E02A10.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SFQ94301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001334230.1">
        <property type="nucleotide sequence ID" value="NM_001347272.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1I6CMA4"/>
    <dbReference type="GeneID" id="183983"/>
    <dbReference type="AGR" id="WB:WBGene00001732"/>
    <dbReference type="CTD" id="183983"/>
    <dbReference type="WormBase" id="E02A10.2g">
        <property type="protein sequence ID" value="CE51819"/>
        <property type="gene ID" value="WBGene00001732"/>
        <property type="gene designation" value="grl-23"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865457at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1I6CMA4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009303876" evidence="2">
        <location>
            <begin position="18"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SFQ94301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="E02A10.2g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1I6CMA4"/>
        </source>
    </evidence>
    <sequence length="341" mass="33861" checksum="0A11BD64D3BF3DD5" modified="2017-01-18" version="1">MRKSIIILLLGLSVATAFLFPSGGGGGGGGGCGGGCGGGGGCGGGGGCGGGCGGGGGGCGGGGGGCGGGGGCGGGCAPPPPPPACGGGCGGGGGGGCGGGGGGGCGGGGGGCGGGGGGCGGGGGGCGGGGGGGCGGGGGGGCGGGCGRKKREAINVVGHDDLNKCNNEELRIILNENTKETVAESIKTLKEKVAGQDYIVVCNEKPAPFTAETDDFCSLQKENVHCTILRINHKEVAEKNEEDKKEEEPKKEEEKKEEVEKKEEDEKKDEEPKKEEEKKEEEQKEEVEKKEEEEKKDEEPKKEEEKKEEEEKKEDEVEEKSEKVEEKELEPKKDEEETKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1I6CMB8</accession>
    <name>A0A1I6CMB8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">clr-1</name>
        <name evidence="18" type="ORF">CELE_F56D1.4</name>
        <name evidence="20" type="ORF">F56D1.4</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SFQ94275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001334206.1">
        <property type="nucleotide sequence ID" value="NM_001347284.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1I6CMB8"/>
    <dbReference type="GeneID" id="3565419"/>
    <dbReference type="AGR" id="WB:WBGene00000548"/>
    <dbReference type="CTD" id="3565419"/>
    <dbReference type="WormBase" id="F56D1.4e">
        <property type="protein sequence ID" value="CE51835"/>
        <property type="gene ID" value="WBGene00000548"/>
        <property type="gene designation" value="clr-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000548">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1I6CMB8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005001">
        <property type="term" value="F:transmembrane receptor protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000092">
        <property type="entry name" value="Tyrosine-protein phosphatase 69D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF495">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 69D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009303873" description="protein-tyrosine-phosphatase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="159"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="394"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="815"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="1014"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="1157"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="1339"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="SFQ94275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="F56D1.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1I6CMB8"/>
        </source>
    </evidence>
    <sequence length="1431" mass="162559" checksum="11FD7D06E9FDF651" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1I6CMB9</accession>
    <name>A0A1I6CMB9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">aakg-1</name>
        <name evidence="8" type="ORF">CELE_Y111B2A.8</name>
        <name evidence="10" type="ORF">Y111B2A.8</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SFQ94286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368617.1">
        <property type="nucleotide sequence ID" value="NM_001379960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1I6CMB9"/>
    <dbReference type="SMR" id="A0A1I6CMB9"/>
    <dbReference type="GeneID" id="3565679"/>
    <dbReference type="AGR" id="WB:WBGene00013732"/>
    <dbReference type="CTD" id="3565679"/>
    <dbReference type="WormBase" id="Y111B2A.8e">
        <property type="protein sequence ID" value="CE51792"/>
        <property type="gene ID" value="WBGene00013732"/>
        <property type="gene designation" value="aakg-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013732">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1I6CMB9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="95"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="180"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="255"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="324"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SFQ94286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y111B2A.8e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1I6CMB9"/>
        </source>
    </evidence>
    <sequence length="456" mass="51095" checksum="E32BEDB4907935F2" modified="2017-01-18" version="1">MRIQCHHYVSHREQLGHRVLSRRRFPIRTLTFTRGTRLKRVSNLSVVILQASLFSSFDSMSIGTAVPDINAIFFDNHDAVYSLFMKAHKCYDLIPTSSKLVVFDTHLPVRKAFYALVYNGVRAAPLWDTDNQRFTGMLTITDFIKILCKHYDKGDNSERIRALEDQQISHWRDQFELDGTLRPFVYIDPNESLHRAVELLCESKVHRLPVLDRKTGNITYILTHKRIMKFLSLYMRDLPRPSFMSCTPRELGIGAWGDILCCHVDTPIHDALELFLKNRVSALPLIDENGRVVDIYAKFDVISLAAESSYDKLDCTVQEALQHRSEWFEGVQTCLETDSLFQVLEAIVKAEVHRLIVTDQDKKVVGVVSLSDILKNLVLDPCQKPPPPPPQSQQAGGGGPPTRNASGTSTGGASSSDSPPHSIPEGIEVEDDDDDDEEAPPPSIDCSTPGPSSAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ACB0I5V8</accession>
    <name>A0ACB0I5V8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">paml-1</name>
        <name evidence="1" type="ORF">CELE_Y70G10A.2</name>
        <name evidence="3" type="ORF">Y70G10A.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAJ1475114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WormBase" id="Y70G10A.2b">
        <property type="protein sequence ID" value="CE54588"/>
        <property type="gene ID" value="WBGene00013498"/>
        <property type="gene designation" value="paml-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1475114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y70G10A.2b"/>
        </source>
    </evidence>
    <sequence length="1252" mass="136345" checksum="001A3E7E5A2BCD35" modified="2026-01-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-05" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>C0KDV0</accession>
    <accession>D0G908</accession>
    <name>C0KDV0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">K+/Cl-Cotransporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="18">Potassium chloride cotransporter isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">kcc-2</name>
        <name evidence="19" type="ORF">CELE_H16O14.1</name>
        <name evidence="21" type="ORF">H16O14.1</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2008-12" db="EMBL/GenBank/DDBJ databases">
            <title>The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tanis J.E."/>
                <person name="Bellemer A."/>
                <person name="Moresco J.J."/>
                <person name="Forbush B."/>
                <person name="Koelle M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="FJ593903">
        <property type="protein sequence ID" value="ACN62949.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD67534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255281.1">
        <property type="nucleotide sequence ID" value="NM_001268352.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C0KDV0"/>
    <dbReference type="SMR" id="C0KDV0"/>
    <dbReference type="PeptideAtlas" id="C0KDV0"/>
    <dbReference type="GeneID" id="177370"/>
    <dbReference type="AGR" id="WB:WBGene00019205"/>
    <dbReference type="CTD" id="177370"/>
    <dbReference type="WormBase" id="H16O14.1a">
        <property type="protein sequence ID" value="CE44206"/>
        <property type="gene ID" value="WBGene00019205"/>
        <property type="gene designation" value="kcc-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001883_1_1_1"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019205">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C0KDV0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006821">
        <property type="term" value="P:chloride transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032228">
        <property type="term" value="P:regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000049">
        <property type="entry name" value="Solute carrier family 12 (potassium/chloride transporter), member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000040">
        <property type="entry name" value="Solute carrier family 12 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF73">
        <property type="entry name" value="KAZACHOC, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="16">
        <location>
            <begin position="90"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="16">
        <location>
            <begin position="372"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="17">
        <location>
            <begin position="671"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="17">
        <location>
            <begin position="800"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="17">
        <location>
            <begin position="988"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="938"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ACN62949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCD67534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WormBase" id="H16O14.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PeptideAtlas" id="C0KDV0"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117799" checksum="69765909298C1655" modified="2009-05-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRJ0</accession>
    <name>C6KRJ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">hum-4</name>
        <name evidence="12" type="ORF">CELE_F46C3.3</name>
        <name evidence="14" type="ORF">F46C3.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAZ65501.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379502.1">
        <property type="nucleotide sequence ID" value="NM_001392845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRJ0"/>
    <dbReference type="SMR" id="C6KRJ0"/>
    <dbReference type="PeptideAtlas" id="C6KRJ0"/>
    <dbReference type="GeneID" id="181335"/>
    <dbReference type="AGR" id="WB:WBGene00002037"/>
    <dbReference type="CTD" id="181335"/>
    <dbReference type="WormBase" id="F46C3.3c">
        <property type="protein sequence ID" value="CE44831"/>
        <property type="gene ID" value="WBGene00002037"/>
        <property type="gene designation" value="hum-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_14_0_1"/>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002037">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRJ0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.530:FF:000012">
        <property type="entry name" value="Heavy chain, Unconventional Myosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059004">
        <property type="entry name" value="MYO15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26570">
        <property type="entry name" value="MYO15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="356"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="11">
        <location>
            <begin position="486"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="10">
        <location>
            <begin position="647"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAZ65501.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F46C3.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="C6KRJ0"/>
        </source>
    </evidence>
    <sequence length="963" mass="111048" checksum="8A378F3744598A17" modified="2010-07-13" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRJ2</accession>
    <name>C6KRJ2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">cfim-2</name>
        <name evidence="6" type="ORF">CELE_D1046.1</name>
        <name evidence="8" type="ORF">D1046.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367218.1">
        <property type="nucleotide sequence ID" value="NM_001380391.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRJ2"/>
    <dbReference type="SMR" id="C6KRJ2"/>
    <dbReference type="STRING" id="6239.D1046.1c.1"/>
    <dbReference type="PaxDb" id="6239-D1046.1c.1"/>
    <dbReference type="PeptideAtlas" id="C6KRJ2"/>
    <dbReference type="GeneID" id="177710"/>
    <dbReference type="KEGG" id="cel:CELE_D1046.1"/>
    <dbReference type="AGR" id="WB:WBGene00008362"/>
    <dbReference type="CTD" id="177710"/>
    <dbReference type="WormBase" id="D1046.1c">
        <property type="protein sequence ID" value="CE43888"/>
        <property type="gene ID" value="WBGene00008362"/>
        <property type="gene designation" value="cfim-2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KFHENRQ"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008362">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRJ2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12643">
        <property type="entry name" value="RRM_CFIm68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057951">
        <property type="entry name" value="CPSF6/7_RSLD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034769">
        <property type="entry name" value="CPSF6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25524">
        <property type="entry name" value="RSLD_CPSF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSF6/7 RSLD" evidence="5">
        <location>
            <begin position="376"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAZ65481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="D1046.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="C6KRJ2"/>
        </source>
    </evidence>
    <sequence length="491" mass="53836" checksum="E0230F46F14958CE" modified="2009-09-01" version="1">MAELDEAALLGDGNEQHDGPIDENALLDGKELKEEDIDDLYDEAIAPTNSTESAKPVSPTITTVTAPTAGIGAKPATSSEGRKYCCYVGNLLWYTTDADLLKALQSTGLARSQFADMKFFENRTNGQSKGYALLVLNSDAAVKQTMEILPTKTIHGQSPTVLSYNKTNQAKLEDAQAKNQTRPDVKKKGFEEGCVNMGTIRIGAGGQTGRTGTSVSGRSGPPPLMMQQVRPTPLMSQPTSLPSNLNQAPQMRLQINGQQVPLMNRAPVPQQTMLGNGPLGGMNQQIQQQPQMMMGQQVRPMMQTSMGIQPMMGMNAPPPMNNQFQNSSRPPQLGSMGVQPLMQMNTAMRPPINGLPPVHVNPQMFPGLQGTVLSDAEFEDVMTRNQTVSSSAIARAITDASVGDIKGASETILTAIQLIKNSRIGHDERCRQLVYGLEHTLKGLESKGYSSRSKSHRDRSRSRERDRKRRRRSRTRSRSYSRSPSPRRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRJ4</accession>
    <name>C6KRJ4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">chca-1</name>
        <name evidence="5" type="ORF">CELE_F58G6.9</name>
        <name evidence="7" type="ORF">F58G6.9</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255414.1">
        <property type="nucleotide sequence ID" value="NM_001268485.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRJ4"/>
    <dbReference type="SMR" id="C6KRJ4"/>
    <dbReference type="GeneID" id="3565521"/>
    <dbReference type="AGR" id="WB:WBGene00044107"/>
    <dbReference type="CTD" id="3565521"/>
    <dbReference type="WormBase" id="F58G6.9c">
        <property type="protein sequence ID" value="CE43814"/>
        <property type="gene ID" value="WBGene00044107"/>
        <property type="gene designation" value="chca-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2212319_0_0_1"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044107">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRJ4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAZ65504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F58G6.9c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="C6KRJ4"/>
        </source>
    </evidence>
    <sequence length="107" mass="12460" checksum="647C4DB7A90CB41F" modified="2009-09-01" version="1">MNMMNMSMTTMSGPVAKRHRMWMWYHVDVEDTVLFKSWTVFDAGTMVWTCFVVAAAGILLEALKYARWATEERMKIDQENVDSKTKYGGIKIPGKSEKYKWVLLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRJ6</accession>
    <name>C6KRJ6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F44D12.8</name>
        <name evidence="2 4" type="ORF">F44D12.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255454.1">
        <property type="nucleotide sequence ID" value="NM_001268525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRJ6"/>
    <dbReference type="GeneID" id="177864"/>
    <dbReference type="AGR" id="WB:WBGene00009685"/>
    <dbReference type="CTD" id="177864"/>
    <dbReference type="WormBase" id="F44D12.8b">
        <property type="protein sequence ID" value="CE43902"/>
        <property type="gene ID" value="WBGene00009685"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038510_0_0_1"/>
    <dbReference type="OrthoDB" id="5832996at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009685">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRJ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37444:SF1">
        <property type="entry name" value="HUN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37444">
        <property type="entry name" value="PROTEIN CBG24900-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAZ65500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F44D12.8b"/>
        </source>
    </evidence>
    <sequence length="446" mass="49705" checksum="46EFF69DF98CA2CE" modified="2009-09-01" version="1">MKSTTNLPIRQNDDNRRRKEGKSQNRRGGPKSKPQPTIVPPRKTPSPSTVTPLPTVIALPAVSTPSPAQANLLKDPTATSPNVPGRERKAIRRKVTKEKVEKDPPKTTVRKKKNQVNQSLSAENTNAKTSSDNDERAGSKNDKPKKKNSHTSSDSRRRRSSEIPSSGSKEDEKSGQKFNKDLAKNFFKHVQSQRAQKRSDDARLERMPESSQLNASARAMRKKKTNAPKTSLDSDLFKPNGEPVWVVPERAPGDCEKNDEGVPITNPELVAALAEDNIEIDEKSWFDHIGDYMSCAMPRGVTLPENHTFDSLAPRDKLEANSDFVSQETVAYNTVKNLVELSEDAIKRFSMKRDGIDDRARPTVTQDTTVETTIETTMPLPPVKALSTDTISTTPGKAISFHMKNVVCLSYDRNHPIQSIRKFRKKMSSKGVMEQSTQPKDSTKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRJ7</accession>
    <name>C6KRJ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type LECtin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F22B3.5</name>
        <name evidence="2 4" type="ORF">F22B3.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65486.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255550.2">
        <property type="nucleotide sequence ID" value="NM_001268621.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRJ7"/>
    <dbReference type="SMR" id="C6KRJ7"/>
    <dbReference type="GeneID" id="184806"/>
    <dbReference type="AGR" id="WB:WBGene00009036"/>
    <dbReference type="CTD" id="184806"/>
    <dbReference type="WormBase" id="F22B3.5b">
        <property type="protein sequence ID" value="CE50163"/>
        <property type="gene ID" value="WBGene00009036"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855627at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47629:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47629">
        <property type="entry name" value="C-TYPE LECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAZ65486.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F22B3.5b"/>
        </source>
    </evidence>
    <sequence length="201" mass="22185" checksum="A5B685A5A3A54763" modified="2015-11-11" version="2">MLLYFQKMIFSLIFLGFASFVGSKLTMIVVYGVPSSSKNKCSLFRDLLCKFLKGAVNIKNAVGYTYNEAVNACANTSCYPTSVSYLEELSYFTVIAHQNIGRTLSTITYVRIDGIRTSACQATPATSKCMSTEGFKFLGPPPKNFDNYDWVTDPSAKRTKDDNCIVMVVNGIRSIKMDVRSCLGTGSPSSQMLFCAKPAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRJ8</accession>
    <name>C6KRJ8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">magi-1</name>
        <name evidence="5" type="ORF">CELE_K01A6.2</name>
        <name evidence="7" type="ORF">K01A6.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="718"/>
            <end position="788"/>
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    </feature>
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            <end position="144"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        <location>
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        <location>
            <begin position="92"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
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            <dbReference type="EMBL" id="CAZ39165.1"/>
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</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">Bristol N2</strain>
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    <dbReference type="Bgee" id="WBGene00012340">
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    </dbReference>
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    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
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            <begin position="32"/>
            <end position="54"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        <location>
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        <location>
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        <location>
            <begin position="424"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAZ65531.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="W08D2.3c"/>
        </source>
    </evidence>
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</entry>
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    <accession>C6KRK8</accession>
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        <submittedName>
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        <name evidence="7" type="ORF">CELE_R102.4</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
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    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
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        </cofactor>
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        <property type="protein sequence ID" value="CE43916"/>
        <property type="gene ID" value="WBGene00011291"/>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="179"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAZ65516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="R102.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="C6KRK8"/>
        </source>
    </evidence>
    <sequence length="403" mass="44478" checksum="28897BDC89C021B0" modified="2009-09-01" version="1">MTKVNGNSNGNGISASTDLLDTPSAYTQKSNKTHTSIDLRSDTVTVPSVEMRRAMAEAIVGDDVYGEDTTTNRLEQRCAELFGKEAGLFVTSGTMGNLLAIMAHCQRGEEIIVGRYNHIHRWEQGNYAQFAGISATTLEVKPDGTMDLNDIEQAIRVKGGYVQIKDESCDDLEVTSIPDCHMPASKLICIENTHNYTGGKALPIEWMRSVKQLAERRDLKVHMDGARIYNAAVASNCSVSKIASFADTVQMCFSKGLGAPVGSIVVGPKDFIDRARHSRKALGGGWRQSGILAAAAHIALDHADATIRADHERAKTLARMINDATPEEFRTKVFAAEKDITNMVLVHCQNGVTVQQLTDFFQKHDILAMTFDARRIRMVLNWNVSDENLETIVEVYKKFLKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRK9</accession>
    <name>C6KRK9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_R102.4</name>
        <name evidence="6 8" type="ORF">R102.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRK9"/>
    <dbReference type="SMR" id="C6KRK9"/>
    <dbReference type="PeptideAtlas" id="C6KRK9"/>
    <dbReference type="AGR" id="WB:WBGene00011291"/>
    <dbReference type="WormBase" id="R102.4e">
        <property type="protein sequence ID" value="CE43816"/>
        <property type="gene ID" value="WBGene00011291"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1469512_0_0_1"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011291">
        <property type="expression patterns" value="Expressed in material anatomical entity and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRK9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAZ65517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="R102.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="C6KRK9"/>
        </source>
    </evidence>
    <sequence length="184" mass="20257" checksum="B4E78E30019749C5" modified="2009-09-01" version="1">MTKVNGNSNGNGISASTDLLDTPSAYTQKSNKTHTSIDLRSDTVTVPSVEMRRAMAEAIVGDDVYGEDTTTNRLEQRCAELFGKEAGLFVTSGTMGNLLAIMAHCQRGEEIIVGRYNHIHRWEQGNYAQFAGISATTLEVKPDGTMDLNDIEQAIRVKGGYVQIKDESCDDLEVTSIPVRFRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRL4</accession>
    <name>C6KRL4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">DDB1- and CUL4-associated factor 11 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">wdr-23</name>
        <name evidence="8" type="ORF">CELE_D2030.9</name>
        <name evidence="10" type="ORF">D2030.9</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the WD repeat LEC14B family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAZ65482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001250545.1">
        <property type="nucleotide sequence ID" value="NM_001263616.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRL4"/>
    <dbReference type="SMR" id="C6KRL4"/>
    <dbReference type="GeneID" id="172518"/>
    <dbReference type="AGR" id="WB:WBGene00008419"/>
    <dbReference type="CTD" id="172518"/>
    <dbReference type="WormBase" id="D2030.9c">
        <property type="protein sequence ID" value="CE43863"/>
        <property type="gene ID" value="WBGene00008419"/>
        <property type="gene designation" value="wdr-23"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008419">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRL4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080135">
        <property type="term" value="P:regulation of cellular response to stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001891">
        <property type="entry name" value="DDB1-and CUL4-associated factor 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002367">
        <property type="entry name" value="DDB1-and CUL4-associated factor 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017399">
        <property type="entry name" value="DCAF11/LEC14B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038135">
        <property type="entry name" value="WD_repeat_p23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="472"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAZ65482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="D2030.9c"/>
        </source>
    </evidence>
    <sequence length="563" mass="64312" checksum="34C0842A25E58240" modified="2009-09-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRL8</accession>
    <name>C6KRL8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F53F4.4</name>
        <name evidence="3 5" type="ORF">F53F4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAZ39163.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256529.1">
        <property type="nucleotide sequence ID" value="NM_001269600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRL8"/>
    <dbReference type="GeneID" id="186177"/>
    <dbReference type="AGR" id="WB:WBGene00009988"/>
    <dbReference type="CTD" id="186177"/>
    <dbReference type="WormBase" id="F53F4.4a">
        <property type="protein sequence ID" value="CE44169"/>
        <property type="gene ID" value="WBGene00009988"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871362at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009988">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRL8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012022676" evidence="2">
        <location>
            <begin position="16"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAZ39163.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F53F4.4a"/>
        </source>
    </evidence>
    <sequence length="688" mass="76826" checksum="F7693DAA4E486086" modified="2009-11-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRL9</accession>
    <name>C6KRL9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F53F4.4</name>
        <name evidence="2 4" type="ORF">F53F4.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAZ39164.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256530.1">
        <property type="nucleotide sequence ID" value="NM_001269601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRL9"/>
    <dbReference type="GeneID" id="186177"/>
    <dbReference type="AGR" id="WB:WBGene00009988"/>
    <dbReference type="CTD" id="186177"/>
    <dbReference type="WormBase" id="F53F4.4b">
        <property type="protein sequence ID" value="CE44787"/>
        <property type="gene ID" value="WBGene00009988"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2401636_0_0_1"/>
    <dbReference type="OrthoDB" id="5871362at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009988">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRL9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013197927" evidence="1">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAZ39164.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F53F4.4b"/>
        </source>
    </evidence>
    <sequence length="93" mass="11065" checksum="7476578FBF316464" modified="2010-06-15" version="2">MLILFFFIFLNVLAAEDLIPTSQCPDNPTFCMLDLLKTWEELRLPETNATNILLPVCFVNLFSRLYHSYHSYQFLRISRKYWFPNKLSSVARK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-09-07" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>G5ECZ4-2</accession>
    <name>DYF2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of WD repeat-containing protein dyf-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Abnormal dye filling protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dyf-2</name>
        <name evidence="5" type="ORF">ZK520.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2006" name="Mol. Biol. Cell" volume="17" first="4801" last="4811">
            <title>Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia.</title>
            <authorList>
                <person name="Efimenko E."/>
                <person name="Blacque O.E."/>
                <person name="Ou G."/>
                <person name="Haycraft C.J."/>
                <person name="Yoder B.K."/>
                <person name="Scholey J.M."/>
                <person name="Leroux M.R."/>
                <person name="Swoboda P."/>
            </authorList>
            <dbReference type="PubMed" id="16957054"/>
            <dbReference type="DOI" id="10.1091/mbc.E06-04-0260"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2012" name="Nat. Cell Biol." volume="14" first="950" last="957">
            <title>The BBSome controls IFT assembly and turnaround in cilia.</title>
            <authorList>
                <person name="Wei Q."/>
                <person name="Zhang Y."/>
                <person name="Li Y."/>
                <person name="Zhang Q."/>
                <person name="Ling K."/>
                <person name="Hu J."/>
            </authorList>
            <dbReference type="PubMed" id="22922713"/>
            <dbReference type="DOI" id="10.1038/ncb2560"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF GLY-361</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="1448" last="1461">
            <title>Dynein-driven retrograde intraflagellar transport is triphasic in C. elegans sensory cilia.</title>
            <authorList>
                <person name="Yi P."/>
                <person name="Li W.J."/>
                <person name="Dong M.Q."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="28479320"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.04.015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN IFT COMPLEX A</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5ECZ4-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_058484"/>
        </isoform>
        <isoform>
            <id>G5ECZ4-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="WormBase" id="ZK520.3b">
        <property type="protein sequence ID" value="CE40490"/>
        <property type="gene ID" value="WBGene00001118"/>
        <property type="gene designation" value="dyf-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q8NEZ3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="ABC42046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK520.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZK520.3b"/>
        </source>
    </evidence>
    <sequence length="576" mass="65369" checksum="711846D76573FA91" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>G8JYB0</accession>
    <name>G8JYB0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">add-1</name>
        <name evidence="8" type="ORF">CELE_F39C12.2</name>
        <name evidence="10" type="ORF">F39C12.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD70846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367832.1">
        <property type="nucleotide sequence ID" value="NM_001380952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JYB0"/>
    <dbReference type="SMR" id="G8JYB0"/>
    <dbReference type="PeptideAtlas" id="G8JYB0"/>
    <dbReference type="GeneID" id="180760"/>
    <dbReference type="AGR" id="WB:WBGene00000072"/>
    <dbReference type="CTD" id="180760"/>
    <dbReference type="WormBase" id="F39C12.2e">
        <property type="protein sequence ID" value="CE34553"/>
        <property type="gene ID" value="WBGene00000072"/>
        <property type="gene designation" value="add-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000072">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JYB0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000013">
        <property type="entry name" value="Class II aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="7">
        <location>
            <begin position="125"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD70846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F39C12.2e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="G8JYB0"/>
        </source>
    </evidence>
    <sequence length="718" mass="80667" checksum="D556F4244C5F1DA5" modified="2012-01-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G8JYB7</accession>
    <name>G8JYB7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">UBP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">hda-6</name>
        <name evidence="17" type="ORF">CELE_F41H10.6</name>
        <name evidence="19" type="ORF">F41H10.6</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD71107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255270.1">
        <property type="nucleotide sequence ID" value="NM_001268341.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JYB7"/>
    <dbReference type="SMR" id="G8JYB7"/>
    <dbReference type="PeptideAtlas" id="G8JYB7"/>
    <dbReference type="GeneID" id="177316"/>
    <dbReference type="AGR" id="WB:WBGene00018319"/>
    <dbReference type="CTD" id="177316"/>
    <dbReference type="WormBase" id="F41H10.6d">
        <property type="protein sequence ID" value="CE45122"/>
        <property type="gene ID" value="WBGene00018319"/>
        <property type="gene designation" value="hda-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_2_1_1"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018319">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JYB7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033558">
        <property type="term" value="F:protein lysine deacetylase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000342">
        <property type="entry name" value="Histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47665">
        <property type="entry name" value="HISTONE DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47665:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="16">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCD71107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="F41H10.6d"/>
        </source>
    </evidence>
    <sequence length="138" mass="14821" checksum="7EF0BD87087304C2" modified="2012-01-25" version="1">MADQSSSSGSSSSSTRPSHNLEIMDSGPAHAVVPLATCPHLKEVKPLPPAKINARTACSECQIGAEVWTCLTCYKYNCGRFVNEHAMMHHLSSSHPMALSMADLSVWCYPCDSYVHNPALIGAKSAAHESKFGETMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G8JYF1</accession>
    <name>G8JYF1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KASH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">unc-83</name>
        <name evidence="3" type="ORF">CELE_W01A11.3</name>
        <name evidence="5" type="ORF">W01A11.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD74264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380085.1">
        <property type="nucleotide sequence ID" value="NM_001392533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JYF1"/>
    <dbReference type="SMR" id="G8JYF1"/>
    <dbReference type="GeneID" id="179033"/>
    <dbReference type="AGR" id="WB:WBGene00006815"/>
    <dbReference type="CTD" id="179033"/>
    <dbReference type="WormBase" id="W01A11.3c">
        <property type="protein sequence ID" value="CE40371"/>
        <property type="gene ID" value="WBGene00006815"/>
        <property type="gene designation" value="unc-83"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010979_0_0_1"/>
    <dbReference type="OrthoDB" id="5805552at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006815">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JYF1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040025">
        <property type="term" value="P:vulval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD74264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W01A11.3c"/>
        </source>
    </evidence>
    <sequence length="740" mass="83610" checksum="1B1C06D66C9E2F88" modified="2012-01-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>G8JYF5</accession>
    <name>G8JYF5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein 60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">hsp-60</name>
        <name evidence="9" type="ORF">CELE_Y22D7AL.5</name>
        <name evidence="11" type="ORF">Y22D7AL.5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122723.1">
        <property type="nucleotide sequence ID" value="NM_001129251.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JYF5"/>
    <dbReference type="SMR" id="G8JYF5"/>
    <dbReference type="PeptideAtlas" id="G8JYF5"/>
    <dbReference type="GeneID" id="175316"/>
    <dbReference type="AGR" id="WB:WBGene00002025"/>
    <dbReference type="CTD" id="175316"/>
    <dbReference type="WormBase" id="Y22D7AL.5b">
        <property type="protein sequence ID" value="CE42184"/>
        <property type="gene ID" value="WBGene00002025"/>
        <property type="gene designation" value="hsp-60"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_1_1"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002025">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JYF5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000031">
        <property type="entry name" value="60 kDa heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000026">
        <property type="entry name" value="Chaperonin 60 subunit alpha 2 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD73758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y22D7AL.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="G8JYF5"/>
        </source>
    </evidence>
    <sequence length="382" mass="40204" checksum="114BDE2C1FD7CA17" modified="2012-01-25" version="1">MLRLARKGLQTAVVRSYAKDVKFGAEGRQAMLVGVNLLADAVSVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIDLKDKYQNLGAKLIQDVANKANEEAGDGTTCATVLARAIAKEGFESIRQGGNAVEIRRGVMNAVEVVVAELKKISKKVTITKDDTLLLRGRGDQTEIEKRIEHITDEIEQSTSDYEKEKLNERLAKLSKGVAVLKIGGGSEVEVGEKKDRVTDALCATRAAVEEGIVPGGGVALLRSLTALKNYKAANEDQQIGVNIVKKALTQPIATIVKNAGLEPSSIIDEVTGNSNTSYGYDALNGKFVDMFEAGIIDPTKVVRTALQDASGVASLLATTECVVTEIPKEEAVGGPAGGMGGMGGMGGMGGMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>G8JYF6</accession>
    <name>G8JYF6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">pde-6</name>
        <name evidence="9" type="ORF">CELE_Y95B8A.10</name>
        <name evidence="11" type="ORF">Y95B8A.10</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD73549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122555.1">
        <property type="nucleotide sequence ID" value="NM_001129083.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JYF6"/>
    <dbReference type="SMR" id="G8JYF6"/>
    <dbReference type="PeptideAtlas" id="G8JYF6"/>
    <dbReference type="GeneID" id="190808"/>
    <dbReference type="KEGG" id="cel:CELE_Y95B8A.10"/>
    <dbReference type="AGR" id="WB:WBGene00022389"/>
    <dbReference type="CTD" id="190808"/>
    <dbReference type="WormBase" id="Y95B8A.10b">
        <property type="protein sequence ID" value="CE41085"/>
        <property type="gene ID" value="WBGene00022389"/>
        <property type="gene designation" value="pde-6"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022389">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JYF6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900194">
        <property type="term" value="P:negative regulation of oocyte maturation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000020">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="426"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD73549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y95B8A.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="G8JYF6"/>
        </source>
    </evidence>
    <sequence length="697" mass="77366" checksum="489B30332C208C83" modified="2012-01-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>G8JYG1</accession>
    <name>G8JYG1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">nxt-1</name>
        <name evidence="7" type="ORF">CELE_Y71F9AM.5</name>
        <name evidence="9" type="ORF">Y71F9AM.5</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD73518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122551.1">
        <property type="nucleotide sequence ID" value="NM_001129079.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JYG1"/>
    <dbReference type="SMR" id="G8JYG1"/>
    <dbReference type="PeptideAtlas" id="G8JYG1"/>
    <dbReference type="GeneID" id="171866"/>
    <dbReference type="AGR" id="WB:WBGene00003836"/>
    <dbReference type="CTD" id="171866"/>
    <dbReference type="WormBase" id="Y71F9AM.5b">
        <property type="protein sequence ID" value="CE41072"/>
        <property type="gene ID" value="WBGene00003836"/>
        <property type="gene designation" value="nxt-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122448_1_1_1"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003836">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JYG1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000006">
        <property type="entry name" value="NTF2-related export protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="6">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD73518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y71F9AM.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="G8JYG1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14769" checksum="2299410CD6E40FC2" modified="2012-01-25" version="1">MSMKTTQEINKEDEELCNESKKFMDVYYDVMDRKREKIGFLYTQVSNAVWNGNPINGFMKALPSTQHDIQSLDAQRLPEGVTGDMSGGMLLNVAGAVTVDGDSKRAFTQTLLLGVEDGKYKVKSDRFRYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYJ4</accession>
    <name>H2KYJ4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F43E2.6</name>
        <name evidence="2 4" type="ORF">F43E2.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD63546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_495542.2">
        <property type="nucleotide sequence ID" value="NM_063141.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYJ4"/>
    <dbReference type="SMR" id="H2KYJ4"/>
    <dbReference type="MEROPS" id="S16.A05"/>
    <dbReference type="GeneID" id="174206"/>
    <dbReference type="AGR" id="WB:WBGene00018394"/>
    <dbReference type="CTD" id="174206"/>
    <dbReference type="WormBase" id="F43E2.6b">
        <property type="protein sequence ID" value="CE32663"/>
        <property type="gene ID" value="WBGene00018394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018394">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYJ4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F43E2.6b"/>
        </source>
    </evidence>
    <sequence length="96" mass="10951" checksum="30FA144E610CC7D7" modified="2012-03-21" version="1">MGKTKAEIQKEERDNRYNRRHAERESAQAEQENVGDETDRSNEIDENCEDISETSANGSNDTNAMQQNVAQAKTVSDHKMDNFMPIPLSKHQKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYJ9</accession>
    <name>H2KYJ9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Polycystin cation channel PKD1/PKD2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">cup-5</name>
        <name evidence="17" type="ORF">CELE_R13A5.1</name>
        <name evidence="19" type="ORF">R13A5.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022722.2">
        <property type="nucleotide sequence ID" value="NM_001027551.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYJ9"/>
    <dbReference type="SMR" id="H2KYJ9"/>
    <dbReference type="PeptideAtlas" id="H2KYJ9"/>
    <dbReference type="GeneID" id="176074"/>
    <dbReference type="AGR" id="WB:WBGene00000846"/>
    <dbReference type="CTD" id="176074"/>
    <dbReference type="WormBase" id="R13A5.1d">
        <property type="protein sequence ID" value="CE46318"/>
        <property type="gene ID" value="WBGene00000846"/>
        <property type="gene designation" value="cup-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263481at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000846">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYJ9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010877">
        <property type="term" value="P:lipid transport involved in lipid storage"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd21050">
        <property type="entry name" value="ELD_TRPML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000207">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049134">
        <property type="entry name" value="MCLN_ECD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF7">
        <property type="entry name" value="SD02261P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21381">
        <property type="entry name" value="MCLN_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Mucolipin extracytosolic" evidence="16">
        <location>
            <begin position="99"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="15">
        <location>
            <begin position="386"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="634"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCD63597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="R13A5.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYJ9"/>
        </source>
    </evidence>
    <sequence length="664" mass="75537" checksum="8063CBC289DFB5E1" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYK0</accession>
    <name>H2KYK0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Polycystin cation channel PKD1/PKD2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">cup-5</name>
        <name evidence="17" type="ORF">CELE_R13A5.1</name>
        <name evidence="19" type="ORF">R13A5.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022721.2">
        <property type="nucleotide sequence ID" value="NM_001027550.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYK0"/>
    <dbReference type="SMR" id="H2KYK0"/>
    <dbReference type="GeneID" id="176074"/>
    <dbReference type="KEGG" id="cel:CELE_R13A5.1"/>
    <dbReference type="AGR" id="WB:WBGene00000846"/>
    <dbReference type="CTD" id="176074"/>
    <dbReference type="WormBase" id="R13A5.1c">
        <property type="protein sequence ID" value="CE46153"/>
        <property type="gene ID" value="WBGene00000846"/>
        <property type="gene designation" value="cup-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263481at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000846">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYK0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010877">
        <property type="term" value="P:lipid transport involved in lipid storage"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd21050">
        <property type="entry name" value="ELD_TRPML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000207">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049134">
        <property type="entry name" value="MCLN_ECD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF7">
        <property type="entry name" value="SD02261P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21381">
        <property type="entry name" value="MCLN_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Mucolipin extracytosolic" evidence="16">
        <location>
            <begin position="121"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="15">
        <location>
            <begin position="408"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCD63612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="R13A5.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYK0"/>
        </source>
    </evidence>
    <sequence length="629" mass="72036" checksum="D223F7F1C1CF1BC1" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYK2</accession>
    <name>H2KYK2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TSC22 domain family protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C30G4.4</name>
        <name evidence="3" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63632.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024438.2">
        <property type="nucleotide sequence ID" value="NM_001029267.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYK2"/>
    <dbReference type="SMR" id="H2KYK2"/>
    <dbReference type="PeptideAtlas" id="H2KYK2"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4b">
        <property type="protein sequence ID" value="CE49993"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYK2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD63632.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C30G4.4b"/>
        </source>
    </evidence>
    <sequence length="318" mass="34895" checksum="E6230FCA39092632" modified="2014-10-29" version="2">MAALFNESLRKVNEQQPPTIIEEDETPKRANRPPDLQGFSILDEKWRSSCSDDSDDSLPVGSYISTAEKPLRFCKSVDFRPLRREAPNLTGDSCSTLPSTPVHKKNPPLPTMSSGGSRFKVVPVETRDPYFSPNGKHAIAKPTAAIKNIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKRAPLVRAKTVVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYK4</accession>
    <name>H2KYK4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tropomodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tmd-2</name>
        <name evidence="7" type="ORF">C08D8.2</name>
        <name evidence="5" type="ORF">CELE_C08D8.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD63653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_505151.2">
        <property type="nucleotide sequence ID" value="NM_072750.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYK4"/>
    <dbReference type="SMR" id="H2KYK4"/>
    <dbReference type="PeptideAtlas" id="H2KYK4"/>
    <dbReference type="GeneID" id="179216"/>
    <dbReference type="KEGG" id="cel:CELE_C08D8.2"/>
    <dbReference type="AGR" id="WB:WBGene00006582"/>
    <dbReference type="CTD" id="179216"/>
    <dbReference type="WormBase" id="C08D8.2a">
        <property type="protein sequence ID" value="CE35225"/>
        <property type="gene ID" value="WBGene00006582"/>
        <property type="gene designation" value="tmd-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031052_2_0_1"/>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006582">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYK4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000798">
        <property type="entry name" value="TropoMoDulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF16">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD63653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C08D8.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYK4"/>
        </source>
    </evidence>
    <sequence length="308" mass="35140" checksum="07D354CC9D779C6C" modified="2012-03-21" version="1">MEEELQQLRTNASSDLMTDEDFIATIESMGVEAQEREINDLLKAMHENRIVSWDEAERILMETDQTPIKCSLPEQTRPTEPENEVDVDQCIKKLLDNDPSLKEINLNNMKRTPVPAIKRLLEALAYNEHCERISLANMGLYDHDINVLVTVIEMNQAIKKVNLETNYLSGDFFSKLFKAALVNESVEEIKAVNQGVSFSTQSEKEIIDAIVKNHGLTKISINFRLPEGRHKVENATLRNGELKRVKRREAAQKARLEAEELAKNPVPKLAPEPKKEPEPKKMAPKFGEEKQAPMPVYKLNRTLSRDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYK9</accession>
    <name>H2KYK9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4794 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F33D4.6</name>
        <name evidence="3 5" type="ORF">F33D4.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD63771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_501261.2">
        <property type="nucleotide sequence ID" value="NM_068860.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYK9"/>
    <dbReference type="PeptideAtlas" id="H2KYK9"/>
    <dbReference type="GeneID" id="177552"/>
    <dbReference type="AGR" id="WB:WBGene00017998"/>
    <dbReference type="CTD" id="177552"/>
    <dbReference type="WormBase" id="F33D4.6a">
        <property type="protein sequence ID" value="CE33634"/>
        <property type="gene ID" value="WBGene00017998"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696840_0_0_1"/>
    <dbReference type="OrthoDB" id="5865092at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017998">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYK9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564272" evidence="2">
        <location>
            <begin position="18"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD63771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F33D4.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYK9"/>
        </source>
    </evidence>
    <sequence length="396" mass="44539" checksum="187CAD0D3D4C7DD5" modified="2012-03-21" version="1">MRHLFVLLPALLAITNAQDHSIDIRALVRDTIDAIKEVPEMMKNQNQTSTSSTPDVSTPQPEKVVKAREDVYDSLLKLPSDIMSQLARDAGFVSEKDQKIQKNAEVSEKKKEETERVEKKKEDDESFSFKTVDDVKKEERKEEIERPSVAAKADDNEDIFSISRLISATGNAIREAQAAQAAQKPQQTPQQEPMITLPPLVPLPPVPLQMPALHIPTTAAQPVTEIMYRPVTRDGKTVYEQVVVLKEANGSVKILPNTLLQQLPEVSTKRVEIKQVKSRSEATEFLAPTFPPMINLFTDPTTTTTPTTTEEPEVTTIEEVEQETIKPKRKSLPRRKIHYLEKKGKDMHSRQFGAKTVQMSDPIDIQAQEEQEPVNILQKEVSLIYSLSLLGILCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYL4</accession>
    <name>H2KYL4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ligand-Gated ion Channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">lgc-58</name>
        <name evidence="17" type="synonym">ggr-2</name>
        <name evidence="17" type="ORF">C45B2.4</name>
        <name evidence="15" type="ORF">CELE_C45B2.4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367470.1">
        <property type="nucleotide sequence ID" value="NM_001380999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYL4"/>
    <dbReference type="SMR" id="H2KYL4"/>
    <dbReference type="GeneID" id="191637"/>
    <dbReference type="AGR" id="WB:WBGene00001587"/>
    <dbReference type="CTD" id="191637"/>
    <dbReference type="WormBase" id="C45B2.4b">
        <property type="protein sequence ID" value="CE39338"/>
        <property type="gene ID" value="WBGene00001587"/>
        <property type="gene designation" value="lgc-58"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001587">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYL4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000152">
        <property type="entry name" value="GABA/Glycine Receptor family (See gbr)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000039">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003563257" evidence="12">
        <location>
            <begin position="21"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="33"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="245"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD63813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C45B2.4b"/>
        </source>
    </evidence>
    <sequence length="513" mass="59066" checksum="1CDF02E199CE7886" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYL7</accession>
    <name>H2KYL7_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">Troponin T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">tnt-3</name>
        <name evidence="6" type="ORF">C14F5.3</name>
        <name evidence="4" type="ORF">CELE_C14F5.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin T family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63846.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359846.1">
        <property type="nucleotide sequence ID" value="NM_001373380.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYL7"/>
    <dbReference type="SMR" id="H2KYL7"/>
    <dbReference type="PeptideAtlas" id="H2KYL7"/>
    <dbReference type="GeneID" id="181052"/>
    <dbReference type="AGR" id="WB:WBGene00006588"/>
    <dbReference type="CTD" id="181052"/>
    <dbReference type="WormBase" id="C14F5.3a">
        <property type="protein sequence ID" value="CE53253"/>
        <property type="gene ID" value="WBGene00006588"/>
        <property type="gene designation" value="tnt-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792825_0_0_1"/>
    <dbReference type="OrthoDB" id="330499at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006588">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYL7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.350:FF:000006">
        <property type="entry name" value="TropoNin T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF24">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD63846.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C14F5.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYL7"/>
        </source>
    </evidence>
    <sequence length="382" mass="45157" checksum="20DF2F36154D6059" modified="2019-07-31" version="2">MSDEEEQYTDEEVEEVDEEEVEADYAPSETDTTRSDRPKTKSFTEDEEGLTEGERAMAAAKRRHEEEQHAKLQDYEERRRTEREKEEEELKKLKEKQEKRKLEREQEEKEMEERRRAADDRRRQEEEERKAKVDQDRRNREEEKNKKNQLSGFQTGGQGGRNFTVAKKAAQNDKFGNIVQAKQEMGMTKEQQEDAKRAFLAAIRKEIPNASEVPQSELKAKIKELHQRICKLETEKYDLEKRHERQEYDMKELNERQRQVTRNSALKKGIDPAEVGNTRYPPKQLIASKFERQRVQTFSDRRALFTNTKKLDTDAYFDWLNSFNYIAPQSLNIISARDDIHAYLNSPDRCPKYIEKEPTICTSQPVFTPRRLSIPAAFLKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYL8</accession>
    <name>H2KYL8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TropoNin T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">tnt-3</name>
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        <name evidence="4" type="ORF">CELE_C14F5.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin T family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63847.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359847.1">
        <property type="nucleotide sequence ID" value="NM_001373383.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYL8"/>
    <dbReference type="SMR" id="H2KYL8"/>
    <dbReference type="STRING" id="6239.C14F5.3b.1"/>
    <dbReference type="PaxDb" id="6239-C14F5.3b"/>
    <dbReference type="PeptideAtlas" id="H2KYL8"/>
    <dbReference type="GeneID" id="181052"/>
    <dbReference type="AGR" id="WB:WBGene00006588"/>
    <dbReference type="CTD" id="181052"/>
    <dbReference type="WormBase" id="C14F5.3b">
        <property type="protein sequence ID" value="CE53313"/>
        <property type="gene ID" value="WBGene00006588"/>
        <property type="gene designation" value="tnt-3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274547_0_0_1"/>
    <dbReference type="OrthoDB" id="330499at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006588">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYL8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.350:FF:000006">
        <property type="entry name" value="TropoNin T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF24">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="633"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="864"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="916"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD63847.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C14F5.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYL8"/>
        </source>
    </evidence>
    <sequence length="1197" mass="136930" checksum="AA8EDCE390C15D3F" modified="2019-07-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYL9</accession>
    <name>H2KYL9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TropoNin T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">tnt-3</name>
        <name evidence="4" type="ORF">C14F5.3</name>
        <name evidence="2" type="ORF">CELE_C14F5.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379643.1">
        <property type="nucleotide sequence ID" value="NM_001392804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYL9"/>
    <dbReference type="SMR" id="H2KYL9"/>
    <dbReference type="PeptideAtlas" id="H2KYL9"/>
    <dbReference type="GeneID" id="181052"/>
    <dbReference type="AGR" id="WB:WBGene00006588"/>
    <dbReference type="CTD" id="181052"/>
    <dbReference type="WormBase" id="C14F5.3c">
        <property type="protein sequence ID" value="CE37091"/>
        <property type="gene ID" value="WBGene00006588"/>
        <property type="gene designation" value="tnt-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_998311_0_0_1"/>
    <dbReference type="OrthoDB" id="330499at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006588">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYL9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF24">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C14F5.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYL9"/>
        </source>
    </evidence>
    <sequence length="279" mass="32846" checksum="E6417B0482BB91A6" modified="2012-03-21" version="1">MSDEEEQYTDEEVEEVDEEEVEADYAPSETDTTRSDRPKTKSFTEDEEGLTEGERAMAAAKRRHEEEQHAKLQDYEERRRTEREKEEEELKKLKEKQEKRKLEREQEEKEMEERRRAADDRRRQEEEERKAKVDQDRRNREEEKNKKNQLSGFQTGGQGGRNFTVAKKAAQNDKFGNIVQAKQEMGMTKEQQEDAKRTRLSSRKPSGIPCGNSQRNTKRIRSSTKRAEGQDKGASSENMQTRDREVRSRETSRTARVRHERAQRASTSSHSQFGSQERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYM0</accession>
    <name>H2KYM0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C39D10.8</name>
        <name evidence="1" type="ORF">CELE_C39D10.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741850.1">
        <property type="nucleotide sequence ID" value="NM_171963.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYM0"/>
    <dbReference type="SMR" id="H2KYM0"/>
    <dbReference type="PeptideAtlas" id="H2KYM0"/>
    <dbReference type="GeneID" id="181046"/>
    <dbReference type="AGR" id="WB:WBGene00016535"/>
    <dbReference type="CTD" id="181046"/>
    <dbReference type="WormBase" id="C39D10.8a">
        <property type="protein sequence ID" value="CE29713"/>
        <property type="gene ID" value="WBGene00016535"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5778155at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016535">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYM0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664:SF3">
        <property type="entry name" value="DUF4440 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664">
        <property type="entry name" value="PROTEIN CBG16427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD63858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C39D10.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYM0"/>
        </source>
    </evidence>
    <sequence length="133" mass="15311" checksum="CF4FACDFFFEA34F1" modified="2012-03-21" version="1">MEVRTQNCNVDDYAAKLFKVYSDTVFADDYEGLLKFYDDSAVLIERGKGSFYGVDSIIGAIKAYHAGLGPGTTKNSEFKVEHTDNVITIRCKYRVQSVLAHETWEGEYIQYWRSEIGQMPKIIRDEFSIDKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYM1</accession>
    <name>H2KYM1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C39D10.8</name>
        <name evidence="1" type="ORF">CELE_C39D10.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367473.1">
        <property type="nucleotide sequence ID" value="NM_001381032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYM1"/>
    <dbReference type="SMR" id="H2KYM1"/>
    <dbReference type="GeneID" id="181046"/>
    <dbReference type="KEGG" id="cel:CELE_C39D10.8"/>
    <dbReference type="AGR" id="WB:WBGene00016535"/>
    <dbReference type="CTD" id="181046"/>
    <dbReference type="WormBase" id="C39D10.8c">
        <property type="protein sequence ID" value="CE30501"/>
        <property type="gene ID" value="WBGene00016535"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5778155at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016535">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYM1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664:SF3">
        <property type="entry name" value="DUF4440 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664">
        <property type="entry name" value="PROTEIN CBG16427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD63860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C39D10.8c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYM1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15084" checksum="AC3B8FAD4A52A5C8" modified="2012-03-21" version="1">MEVRTQNCNVDDYAAKLFKVYSDTVFADDYEGLLKFYDDSAVLIERGKGSFYGVDSIIGAIKAYHAGLGPGTTKNSEFKVEHTDNVITIRCKYRSVLAHETWEGEYIQYWRSEIGQMPKIIRDEFSIDKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYM2</accession>
    <name>H2KYM2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">unc-73</name>
        <name evidence="10" type="ORF">CELE_F55C7.7</name>
        <name evidence="12" type="ORF">F55C7.7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD63881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001249513.1">
        <property type="nucleotide sequence ID" value="NM_001262584.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYM2"/>
    <dbReference type="SMR" id="H2KYM2"/>
    <dbReference type="PeptideAtlas" id="H2KYM2"/>
    <dbReference type="GeneID" id="171988"/>
    <dbReference type="AGR" id="WB:WBGene00006805"/>
    <dbReference type="CTD" id="171988"/>
    <dbReference type="WormBase" id="F55C7.7g">
        <property type="protein sequence ID" value="CE43442"/>
        <property type="gene ID" value="WBGene00006805"/>
        <property type="gene designation" value="unc-73"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006805">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYM2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036194">
        <property type="term" value="C:muscle cell projection"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048808">
        <property type="term" value="P:male genitalia morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008078">
        <property type="term" value="P:mesodermal cell migration"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045773">
        <property type="term" value="P:positive regulation of axon extension"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035022">
        <property type="term" value="P:positive regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016601">
        <property type="term" value="P:Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040012">
        <property type="term" value="P:regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040028">
        <property type="term" value="P:regulation of vulval development"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd13241">
        <property type="entry name" value="PH2_Kalirin_Trio_p63RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000008">
        <property type="entry name" value="rho guanine nucleotide exchange factor 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SOS1_NGEF_PH"/>
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        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRIO, ISOFORM A"/>
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        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PH"/>
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        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
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        <property type="entry name" value="SH3-domain"/>
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        <property type="entry name" value="DH_1"/>
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        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="249"/>
            <end position="427"/>
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    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="445"/>
            <end position="553"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="543"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="570"/>
            <end position="638"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="124"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="150"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="156"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="523"/>
            <end position="537"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="590"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="604"/>
            <end position="615"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="616"/>
            <end position="630"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD63881.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F55C7.7g"/>
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    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYM2"/>
        </source>
    </evidence>
    <sequence length="638" mass="69931" checksum="6672F94566B0E72E" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYM3</accession>
    <name>H2KYM3_CAEEL</name>
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        <submittedName>
            <fullName evidence="13">Rho guanine nucleotide exchange factor 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">unc-73</name>
        <name evidence="13" type="ORF">CELE_F55C7.7</name>
        <name evidence="15" type="ORF">F55C7.7</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
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        <property type="component" value="Chromosome I"/>
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        <location>
            <begin position="51"/>
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        </location>
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        <location>
            <begin position="484"/>
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        <location>
            <begin position="784"/>
            <end position="869"/>
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        <location>
            <begin position="876"/>
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        <location>
            <begin position="107"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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</entry>
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    <accession>H2KYM4</accession>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYM5</accession>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD63890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491606.2">
        <property type="nucleotide sequence ID" value="NM_059205.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYM5"/>
    <dbReference type="PeptideAtlas" id="H2KYM5"/>
    <dbReference type="GeneID" id="172200"/>
    <dbReference type="AGR" id="WB:WBGene00015635"/>
    <dbReference type="CTD" id="172200"/>
    <dbReference type="WormBase" id="C09D4.4b">
        <property type="protein sequence ID" value="CE34255"/>
        <property type="gene ID" value="WBGene00015635"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015635">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYM5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000653">
        <property type="entry name" value="Protein CBG25340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF5">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="624"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD63890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C09D4.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYM5"/>
        </source>
    </evidence>
    <sequence length="915" mass="103662" checksum="712059CFEA023434" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYM9</accession>
    <name>H2KYM9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">lips-7</name>
        <name evidence="3" type="ORF">C09E8.2</name>
        <name evidence="1" type="ORF">CELE_C09E8.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD63931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370413.1">
        <property type="nucleotide sequence ID" value="NM_001383781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYM9"/>
    <dbReference type="SMR" id="H2KYM9"/>
    <dbReference type="GeneID" id="173446"/>
    <dbReference type="KEGG" id="cel:CELE_C09E8.2"/>
    <dbReference type="AGR" id="WB:WBGene00015645"/>
    <dbReference type="CTD" id="173446"/>
    <dbReference type="WormBase" id="C09E8.2b">
        <property type="protein sequence ID" value="CE32123"/>
        <property type="gene ID" value="WBGene00015645"/>
        <property type="gene designation" value="lips-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104769_0_0_1"/>
    <dbReference type="OrthoDB" id="5792589at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015645">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYM9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000377">
        <property type="entry name" value="LIPaSe related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF3">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD63931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C09E8.2b"/>
        </source>
    </evidence>
    <sequence length="176" mass="19485" checksum="0EF00A7AE5CD7B0F" modified="2012-03-21" version="1">MYYQNFRAMIIAVRQYTGQKVDVIGYSMGSPLARKAILGGQCVDTREILGAPLTELVDTFLSVAGANYGSVLCILPVPVGTCNKKNGLHCDSEFLQDINNQHRYEGSHVFSIFSTADEKIGFRSCGRPVSPIRGGTGFVKRDGLNHDQLMDTTHPLQRNFILYHSPKAPKSHRNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYN1</accession>
    <name>H2KYN1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">pkg-2</name>
        <name evidence="22" type="ORF">C09G4.2</name>
        <name evidence="20" type="ORF">CELE_C09G4.2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="3"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD63995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741468.1">
        <property type="nucleotide sequence ID" value="NM_171402.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYN1"/>
    <dbReference type="SMR" id="H2KYN1"/>
    <dbReference type="PeptideAtlas" id="H2KYN1"/>
    <dbReference type="GeneID" id="177659"/>
    <dbReference type="AGR" id="WB:WBGene00015650"/>
    <dbReference type="CTD" id="177659"/>
    <dbReference type="WormBase" id="C09G4.2a">
        <property type="protein sequence ID" value="CE31156"/>
        <property type="gene ID" value="WBGene00015650"/>
        <property type="gene designation" value="pkg-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_73_2_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015650">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYN1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000334">
        <property type="entry name" value="Protein Kinase, cGMP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF91">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0140">cGMP</keyword>
    <keyword evidence="11" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="36"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="274"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="19">
        <location>
            <begin position="530"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="280"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCD63995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="C09G4.2a"/>
        </source>
    </evidence>
    <sequence length="581" mass="67013" checksum="3744C6D77C64C9A9" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYN4</accession>
    <name>H2KYN4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C28C12.11</name>
        <name evidence="2" type="ORF">CELE_C28C12.11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD64015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_501443.1">
        <property type="nucleotide sequence ID" value="NM_069042.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYN4"/>
    <dbReference type="SMR" id="H2KYN4"/>
    <dbReference type="GeneID" id="177650"/>
    <dbReference type="AGR" id="WB:WBGene00016181"/>
    <dbReference type="CTD" id="177650"/>
    <dbReference type="WormBase" id="C28C12.11a">
        <property type="protein sequence ID" value="CE29192"/>
        <property type="gene ID" value="WBGene00016181"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5860260at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016181">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYN4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD64015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C28C12.11a"/>
        </source>
    </evidence>
    <sequence length="250" mass="28530" checksum="6333E253062F4CB3" modified="2012-03-21" version="1">MLLRRSLFVLDIIALLAIVVFLVFLPADRCLNFEASEQTPRNVDKKCHLHPVHHPNFSFTENLKTNDHLIDPSHQVTICHRLKWSHYSFWDSMYLILLPALTCVFLIFYTVLEICEFDVFVGQVQTTGLVIVSAISVIYSIAVITHEKNRIETEWPLLAHAYVLGAKEGETTVNVPKTWQYSIAMCILSALFKIGRVLVQHFIGDKKFFFDDDSQRDDQNGEPVLLAGSEEVAGTTTILNDSRYSRIETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYP3</accession>
    <name>H2KYP3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Calx-beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24 26" type="primary">ncx-2</name>
        <name evidence="26" type="ORF">C10G8.5</name>
        <name evidence="24" type="ORF">CELE_C10G8.5</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD64161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_504415.2">
        <property type="nucleotide sequence ID" value="NM_072014.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYP3"/>
    <dbReference type="SMR" id="H2KYP3"/>
    <dbReference type="PeptideAtlas" id="H2KYP3"/>
    <dbReference type="GeneID" id="178918"/>
    <dbReference type="AGR" id="WB:WBGene00003567"/>
    <dbReference type="CTD" id="178918"/>
    <dbReference type="WormBase" id="C10G8.5b">
        <property type="protein sequence ID" value="CE30725"/>
        <property type="gene ID" value="WBGene00003567"/>
        <property type="gene designation" value="ncx-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003567">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYP3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032452">
        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00845">
        <property type="entry name" value="caca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF65">
        <property type="entry name" value="NA_CA-EXCHANGE PROTEIN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16494">
        <property type="entry name" value="Na_Ca_ex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 22" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003563874" evidence="22">
        <location>
            <begin position="23"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="899"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="23">
        <location>
            <begin position="356"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="23">
        <location>
            <begin position="487"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="605"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CCD64161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WormBase" id="C10G8.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="27">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYP3"/>
        </source>
    </evidence>
    <sequence length="925" mass="103118" checksum="42A19DA8E003FEEE" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYP4</accession>
    <name>H2KYP4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Calx-beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24 26" type="primary">ncx-2</name>
        <name evidence="26" type="ORF">C10G8.5</name>
        <name evidence="24" type="ORF">CELE_C10G8.5</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD64163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023644.1">
        <property type="nucleotide sequence ID" value="NM_001028473.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYP4"/>
    <dbReference type="SMR" id="H2KYP4"/>
    <dbReference type="GeneID" id="178918"/>
    <dbReference type="AGR" id="WB:WBGene00003567"/>
    <dbReference type="CTD" id="178918"/>
    <dbReference type="WormBase" id="C10G8.5d">
        <property type="protein sequence ID" value="CE32583"/>
        <property type="gene ID" value="WBGene00003567"/>
        <property type="gene designation" value="ncx-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003567">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYP4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032452">
        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00845">
        <property type="entry name" value="caca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF65">
        <property type="entry name" value="NA_CA-EXCHANGE PROTEIN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16494">
        <property type="entry name" value="Na_Ca_ex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 22" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564204" evidence="22">
        <location>
            <begin position="23"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="800"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="909"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="23">
        <location>
            <begin position="353"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="23">
        <location>
            <begin position="484"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="602"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CCD64163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WormBase" id="C10G8.5d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="27">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYP4"/>
        </source>
    </evidence>
    <sequence length="950" mass="105570" checksum="67DD41C0B6B0E348" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYP6</accession>
    <name>H2KYP6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C10G11.1</name>
        <name evidence="2" type="ORF">CELE_C10G11.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD64177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367495.1">
        <property type="nucleotide sequence ID" value="NM_001380507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYP6"/>
    <dbReference type="SMR" id="H2KYP6"/>
    <dbReference type="GeneID" id="182505"/>
    <dbReference type="AGR" id="WB:WBGene00015685"/>
    <dbReference type="CTD" id="182505"/>
    <dbReference type="WormBase" id="C10G11.1a">
        <property type="protein sequence ID" value="CE34257"/>
        <property type="gene ID" value="WBGene00015685"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1220664_0_0_1"/>
    <dbReference type="OrthoDB" id="5891737at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015685">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYP6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD64177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C10G11.1a"/>
        </source>
    </evidence>
    <sequence length="41" mass="4457" checksum="92E1BE4BBD913552" modified="2012-03-21" version="1">MKMPKSTDLPAVPTRAMTPGPKPSCDPPNNNKSAMKMKVMQ</sequence>
</entry>
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    <accession>H2KZ10</accession>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <strain evidence="7 8">Bristol N2</strain>
        </source>
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            <location evidence="1">Membrane</location>
        </subcellularLocation>
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    <dbReference type="WormBase" id="C25E10.3c">
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        <property type="gene ID" value="WBGene00016093"/>
        <property type="gene designation" value="srsx-34"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079993_0_0_1"/>
    <dbReference type="OrthoDB" id="370281at2759"/>
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    </dbReference>
    <dbReference type="Bgee" id="WBGene00016093">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ10">
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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            <end position="32"/>
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            <begin position="44"/>
            <end position="67"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="187"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="237"/>
            <end position="257"/>
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            <begin position="23"/>
            <end position="254"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD65649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C25E10.3c"/>
        </source>
    </evidence>
    <sequence length="299" mass="33651" checksum="D1578DAFFCBB5FCF" modified="2012-03-21" version="1">MLPVELIPLGIILFFVAIIGIIGNSIMIIAFLKHAKLRSPCHYFIAITCLADSLHNYGQIIFTAHLFFDIQTSHFVCTLLNIPTLIGVISGSCWILAMGIDRFFACKWPASYRSLVSYSLYTFLQLVFPFIYTSIFLLFAFLEVDYTPMTCAIPLAMGSKTFVTWSFSNMALNAFTMMLYTSVYFLVRKKETGQKFKAVFKSIFITATLVIIGWTVTCISNTFVVLFVLYGKQIVNMYAGIPVNIACASNIFVFYRINLDYRSGIRKIFPCKTTTVGSIHVHIERNASITTPGHSPNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ13</accession>
    <name>H2KZ13_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Zc3h12a-like Ribonuclease NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">eri-9</name>
        <name evidence="5" type="ORF">C26E6.7</name>
        <name evidence="3" type="ORF">CELE_C26E6.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD65732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_498043.2">
        <property type="nucleotide sequence ID" value="NM_065642.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ13"/>
    <dbReference type="SMR" id="H2KZ13"/>
    <dbReference type="IntAct" id="H2KZ13">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="175665"/>
    <dbReference type="AGR" id="WB:WBGene00016143"/>
    <dbReference type="CTD" id="175665"/>
    <dbReference type="WormBase" id="C26E6.7b">
        <property type="protein sequence ID" value="CE32145"/>
        <property type="gene ID" value="WBGene00016143"/>
        <property type="gene designation" value="eri-9"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TGT3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430988_0_0_1"/>
    <dbReference type="OrthoDB" id="5875795at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016143">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ13">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028079">
        <property type="entry name" value="RNase_Zc3h12a_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14626">
        <property type="entry name" value="RNase_Zc3h12a_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="337"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="68"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="503"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="26"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="42"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD65732.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C26E6.7b"/>
        </source>
    </evidence>
    <sequence length="635" mass="73520" checksum="45511D3B6F9023A1" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ14</accession>
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        <submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Rhabditina</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD65765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001023680.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KZ14"/>
    <dbReference type="GeneID" id="179157"/>
    <dbReference type="KEGG" id="cel:CELE_C26F1.1"/>
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    <dbReference type="CTD" id="179157"/>
    <dbReference type="WormBase" id="C26F1.1a">
        <property type="protein sequence ID" value="CE32807"/>
        <property type="gene ID" value="WBGene00016146"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2266145_0_0_1"/>
    <dbReference type="OrthoDB" id="5877154at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016146">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KZ14">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0640">Prion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C26F1.1a"/>
        </source>
    </evidence>
    <sequence length="103" mass="11035" checksum="DCFCBD724DECF470" modified="2012-03-21" version="1">MLGICLQGYQQQPQQQFMGQVEQGVEITPDQINSGYQPQQQMGFQSQQQQFSSIPNSGSSNYGADSSFSGSQPAGLVQSVASSAAFEAAGVAPSARRLRKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZ17</accession>
    <name>H2KZ17_CAEEL</name>
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        <submittedName>
            <fullName evidence="13">DiSHevelled related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">dsh-1</name>
        <name evidence="15" type="ORF">C34F11.9</name>
        <name evidence="13" type="ORF">CELE_C34F11.9</name>
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    <organism evidence="13 14">
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="interaction">
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            <id>H2KZ17</id>
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        <interactant intactId="EBI-6499941">
            <id>Q8WQC0</id>
            <label>rgs-7</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-2923230">
            <id>H2KZ17</id>
        </interactant>
        <interactant intactId="EBI-311986">
            <id>G5EGG0</id>
            <label>uso-1</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSH family.</text>
    </comment>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD65830.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="H2KZ17"/>
        </source>
    </evidence>
    <sequence length="702" mass="77266" checksum="250E5F559B67DBE4" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>O01159-2</accession>
    <name>RSP7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Probable splicing factor, arginine/serine-rich 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>p54</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rsp-7</name>
        <name type="ORF">D2089.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2000" name="EMBO J." volume="19" first="1625" last="1637">
            <title>Functional characterization of SR and SR-related genes in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Longman D."/>
                <person name="Johnstone I.L."/>
                <person name="Caceres J.F."/>
            </authorList>
            <dbReference type="PubMed" id="10747030"/>
            <dbReference type="DOI" id="10.1093/emboj/19.7.1625"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O01159-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O01159-2</id>
            <name evidence="1">b</name>
            <sequence type="described" ref="VSP_051634 VSP_051635"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379303.1">
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    </dbReference>
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        <property type="protein sequence ID" value="CE30507"/>
        <property type="gene ID" value="WBGene00004704"/>
        <property type="gene designation" value="rsp-7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="CAA85414.2"/>
        </source>
    </evidence>
    <sequence length="137" mass="15287" checksum="50F63764F259C1C7" modified="2002-06-01" version="3">MSGEEKEKVKILHVANISTSATRDHIYNMFNYLGKIQDLKVYPSEGNITANTLLKTAFIKFDDERCVEVAQHLTNTVVIDCAIVCLPYPNPVIPDEESFFNSGGSTTAGQRQLPPHVTNKIQESDDGSALFYWPLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2025-10-08" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>O62178</accession>
    <name>O62178_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rme-8</name>
        <name evidence="3" type="ORF">CELE_F18C12.2</name>
        <name evidence="5" type="ORF">F18C12.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAA99832.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21087">
        <property type="entry name" value="T21087"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021395.1">
        <property type="nucleotide sequence ID" value="NM_001026224.6"/>
    </dbReference>
    <dbReference type="SMR" id="O62178"/>
    <dbReference type="GeneID" id="172594"/>
    <dbReference type="KEGG" id="cel:CELE_F18C12.2"/>
    <dbReference type="AGR" id="WB:WBGene00004378"/>
    <dbReference type="CTD" id="35939"/>
    <dbReference type="WormBase" id="F18C12.2b">
        <property type="protein sequence ID" value="CE30345"/>
        <property type="gene ID" value="WBGene00004378"/>
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        <property type="entry name" value="GRV2/DNAJC13"/>
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        <property type="entry name" value="GRV2/DNAJC13_N"/>
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    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
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        <property type="entry name" value="J_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RME-8_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50076">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="1321"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2250"/>
            <end position="2271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2250"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2261"/>
            <end position="2271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA99832.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F18C12.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="O62178"/>
        </source>
    </evidence>
    <sequence length="2271" mass="258338" checksum="E61592E6AB6F379F" modified="2002-06-01" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>O76788</accession>
    <name>O76788_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Potassium channel domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16">Putative potassium channel subunit n2P17m1-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">twk-17</name>
        <name evidence="19" type="ORF">C44E12.3</name>
        <name evidence="17" type="ORF">CELE_C44E12.3</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="1998" name="Ann. N. Y. Acad. Sci." volume="0" first="0" last="0">
            <title>Analysis of genomic organization of nematode 4TM potassium channels.</title>
            <authorList>
                <person name="Wang Z.-W."/>
                <person name="Kunkel M.T."/>
                <person name="Wei A."/>
                <person name="Butler A."/>
                <person name="Salkoff L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AF083644">
        <property type="protein sequence ID" value="AAC32855.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024463.1">
        <property type="nucleotide sequence ID" value="NM_001029292.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O76788"/>
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        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006671"/>
    <dbReference type="CTD" id="181024"/>
    <dbReference type="WormBase" id="C44E12.3b">
        <property type="protein sequence ID" value="CE30901"/>
        <property type="gene ID" value="WBGene00006671"/>
        <property type="gene designation" value="twk-17"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006671">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O76788">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF322">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="11 12 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="176"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="310"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AAC32855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCD67334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="C44E12.3b"/>
        </source>
    </evidence>
    <sequence length="498" mass="56896" checksum="D23AF21A694BDE33" modified="1998-11-01" version="1">MFAEWARTAHTGIYPDNPTAVALLPFFAAAAIRYQNIGRVKWEEYNRREGIEDVPEQPIVVRVPIWRRILKLLKILLPHVGLNVLLLSYIAMGATVFIWLEADHELEGRKAKVKHVFDIYSQIMNETIALTNNQSDQATIVSRMRPLLESLSRAHEYDDKFTDTNQLWTGEQDGMTTRWTFAAATLYALTVITSTGYDHVTPATDPGRIFTVFFGLIGIPLMFITAADIGKFLSEIVIRTYAKLLAMWKMIANLVELVRTHLFDTDVDSIDSMELKKSKKRNASSLDDEECEDEEDRLQLPIASYFTLIIGYCCVGSLLFNTFEKGPVWSFIHGVFFSFNTITTIGLGNIRVQQHYYLALAVSYVIIGLAVITASLDLCSSTLKRTFTKLHYFGRKIRGARRGFANMSDDIREAMRIIAALKKTRPSKDRITLEDLKRFLEVQEHLLRQPYVPYNVHLLRWIEDNYAQYMDDVSGGKTPMSPSRLSHKMSSSDPMLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2026-01-28" version="177" xmlns="https://uniprot.org/uniprot">
    <accession>O76792</accession>
    <name>O76792_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Potassium channel domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16">Putative potassium channel subunit n2P17m2-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">twk-17</name>
        <name evidence="19" type="ORF">C44E12.3</name>
        <name evidence="17" type="ORF">CELE_C44E12.3</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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                <person name="Kunkel M.T."/>
                <person name="Wei A."/>
                <person name="Butler A."/>
                <person name="Salkoff L."/>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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                <person name="Waterston R."/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AAC32862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCD67336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="C44E12.3d"/>
        </source>
    </evidence>
    <sequence length="562" mass="63991" checksum="1CD297F057B64CF6" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>P34568-2</accession>
    <name>SPOP_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Speckle-type POZ protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">BTB and MATH domain-containing protein 43</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">HIB homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spop-1</name>
        <name evidence="2" type="synonym">bath-43</name>
        <name evidence="2" type="ORF">T16H12.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Dev. Cell" volume="10" first="719" last="729">
            <title>A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.</title>
            <authorList>
                <person name="Zhang Q."/>
                <person name="Zhang L."/>
                <person name="Wang B."/>
                <person name="Ou C.-Y."/>
                <person name="Chien C.-T."/>
                <person name="Jiang J."/>
            </authorList>
            <dbReference type="PubMed" id="16740475"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2006.05.004"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="Proc. Natl. Acad. Sci. U.S.A." volume="118" first="0" last="0">
            <title>The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity.</title>
            <authorList>
                <person name="Snoznik C."/>
                <person name="Medvedeva V."/>
                <person name="Mojsilovic-Petrovic J."/>
                <person name="Rudich P."/>
                <person name="Oosten J."/>
                <person name="Kalb R.G."/>
                <person name="Lamitina T."/>
            </authorList>
            <dbReference type="PubMed" id="34593637"/>
            <dbReference type="DOI" id="10.1073/pnas.2104664118"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 187-TYR--TYR-451; TRP-195 AND PHE-197</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34568-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_014361"/>
        </isoform>
        <isoform>
            <id>P34568-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022765.1">
        <property type="nucleotide sequence ID" value="NM_001027594.6"/>
    </dbReference>
    <dbReference type="WormBase" id="T16H12.5b">
        <property type="protein sequence ID" value="CE00510"/>
        <property type="gene ID" value="WBGene00011815"/>
        <property type="gene designation" value="spop-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T16H12.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T16H12.5b"/>
        </source>
    </evidence>
    <sequence length="409" mass="46414" checksum="7A6E116683EB098A" modified="2002-05-15" version="2">MEVGMGNDEVVSSGSGNSAHGRSISPSPSSASHGDPLLPVAENWCHTQVKVVKFNYMWTINNFSFCREEMGEVLKSSTFSAGCNDKLKWCLRINPKGLDEESRDYLSLYLLLVQCNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPGDRLSIFCEVSVVAETVNVTGQTNVSQLFKVPPCRLADDMYGLFDNKQFSDFTLVCKSDLGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDNASLTLMLADMYSASQLRAHSINFINVNANEVMDTEGWEDLVRDHPKLLEEVFRALATQQTPPVVLVQPPKKRPKHNCPY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2026-01-28" version="179" xmlns="https://uniprot.org/uniprot">
    <accession>Q19289-2</accession>
    <name>IFB1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Intermediate filament protein ifb-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cel IF B1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Intermediate filament protein B1</fullName>
            <shortName>IF-B1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ifb-1</name>
        <name type="ORF">F10C1.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="EMBO J." volume="13" first="2625" last="2638">
            <title>Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dodemont H."/>
                <person name="Riemer D."/>
                <person name="Ledger T.N."/>
                <person name="Weber K."/>
            </authorList>
            <dbReference type="PubMed" id="8013462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Proc. Natl. Acad. Sci. U.S.A." volume="98" first="7863" last="7868">
            <title>Essential roles for four cytoplasmic intermediate filament proteins in Caenorhabditis elegans development.</title>
            <authorList>
                <person name="Karabinos A."/>
                <person name="Schmidt H."/>
                <person name="Harborth J."/>
                <person name="Schnabel R."/>
                <person name="Weber K."/>
            </authorList>
            <dbReference type="PubMed" id="11427699"/>
            <dbReference type="DOI" id="10.1073/pnas.121169998"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="J. Mol. Biol." volume="333" first="307" last="319">
            <title>In vivo and in vitro evidence that the four essential intermediate filament (IF) proteins A1, A2, A3 and B1 of the nematode Caenorhabditis elegans form an obligate heteropolymeric IF system.</title>
            <authorList>
                <person name="Karabinos A."/>
                <person name="Schulze E."/>
                <person name="Schuenemann J."/>
                <person name="Parry D.A.D."/>
                <person name="Weber K."/>
            </authorList>
            <dbReference type="PubMed" id="14529618"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2003.08.041"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH IFA-1; IFA-2; IFA-3 AND IFA-4</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="Dev. Biol." volume="267" first="216" last="229">
            <title>Intermediate filaments are required for C. elegans epidermal elongation.</title>
            <authorList>
                <person name="Woo W.-M."/>
                <person name="Goncharov A."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="14975728"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2003.11.007"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="Dev. Biol." volume="350" first="267" last="278">
            <title>PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.</title>
            <authorList>
                <person name="Hetherington S."/>
                <person name="Gally C."/>
                <person name="Fritz J.A."/>
                <person name="Polanowska J."/>
                <person name="Reboul J."/>
                <person name="Schwab Y."/>
                <person name="Zahreddine H."/>
                <person name="Behm C."/>
                <person name="Labouesse M."/>
            </authorList>
            <dbReference type="PubMed" id="21130760"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.11.025"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19289-1</id>
            <name>a</name>
            <name>B1b</name>
            <name>IFB-1B</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q19289-2</id>
            <name>b</name>
            <name>B1a IFB-1A</name>
            <sequence type="described" ref="VSP_010147"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_495137.1">
        <property type="nucleotide sequence ID" value="NM_062736.5"/>
    </dbReference>
    <dbReference type="WormBase" id="F10C1.2a">
        <property type="protein sequence ID" value="CE02618"/>
        <property type="gene ID" value="WBGene00002053"/>
        <property type="gene designation" value="ifb-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="558" mass="63700" checksum="A25DFFAE9DAD7AAF" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-06-13" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q1HAZ7</accession>
    <name>Q1HAZ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM GPCR serpentine receptor class x (Srx) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">srx-125</name>
        <name evidence="3" type="ORF">CELE_F32H5.6</name>
        <name evidence="5" type="ORF">F32H5.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAK12564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041111.1">
        <property type="nucleotide sequence ID" value="NM_001047646.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1HAZ7"/>
    <dbReference type="GeneID" id="185218"/>
    <dbReference type="UCSC" id="F32H5.6a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006016"/>
    <dbReference type="CTD" id="185218"/>
    <dbReference type="WormBase" id="F32H5.6b">
        <property type="protein sequence ID" value="CE40227"/>
        <property type="gene ID" value="WBGene00006016"/>
        <property type="gene designation" value="srx-125"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070417_0_0_1"/>
    <dbReference type="OrthoDB" id="5837543at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006016">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46611:SF3">
        <property type="entry name" value="7TM GPCR SERPENTINE RECEPTOR CLASS X (SRX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46611">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAK12564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F32H5.6b"/>
        </source>
    </evidence>
    <sequence length="90" mass="10561" checksum="53E89743AA608283" modified="2006-06-13" version="1">MYIQSVLQDTLHLIDMINCTILFKLNSAIWYQFIFLSVSFLSIHALDGSVMLYFHTEIHPQWCRRLLKPKSRTGTIFVNRSKISSFHPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-06-13" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q1HAZ8</accession>
    <name>Q1HAZ8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zf-C3H1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F53C11.5</name>
        <name evidence="2 4" type="ORF">F53C11.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAK12562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041122.1">
        <property type="nucleotide sequence ID" value="NM_001047657.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1HAZ8"/>
    <dbReference type="PeptideAtlas" id="Q1HAZ8"/>
    <dbReference type="GeneID" id="179874"/>
    <dbReference type="UCSC" id="F53C11.5a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009975"/>
    <dbReference type="CTD" id="179874"/>
    <dbReference type="WormBase" id="F53C11.5c">
        <property type="protein sequence ID" value="CE40231"/>
        <property type="gene ID" value="WBGene00009975"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_321657_0_0_1"/>
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    </protein>
    <gene>
        <name type="primary">mig-15</name>
        <name type="ORF">ZC504.4</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="1998-08" db="EMBL/GenBank/DDBJ databases">
            <title>MIG-15, a NIK ortholog of the STE20 family of serine/threonine protein kinases, is involved in cell migration and signal transduction in C. elegans.</title>
            <authorList>
                <person name="Zhu X."/>
                <person name="Acharya P."/>
                <person name="Hedgecock E.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 369-1096 (ISOFORM C)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Curr. Biol." volume="12" first="622" last="631">
            <title>A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans.</title>
            <authorList>
                <person name="Poinat P."/>
                <person name="De Arcangelis A."/>
                <person name="Sookhareea S."/>
                <person name="Zhu X."/>
                <person name="Hedgecock E.M."/>
                <person name="Labouesse M."/>
                <person name="Georges-Labouesse E."/>
            </authorList>
            <dbReference type="PubMed" id="11967148"/>
            <dbReference type="DOI" id="10.1016/S0960-9822(02)00764-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Dev. Biol." volume="368" first="404" last="414">
            <title>mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites.</title>
            <authorList>
                <person name="Martynovsky M."/>
                <person name="Wong M.C."/>
                <person name="Byrd D.T."/>
                <person name="Kimble J."/>
                <person name="Schwarzbauer J.E."/>
            </authorList>
            <dbReference type="PubMed" id="22732572"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2012.06.011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="online journal article" date="1997" name="Worm Breeder's Gazette">
            <title>mig-15 encodes a novel Ser/Thr protein kinase of the Ste-20/p65PAK family.</title>
            <authorList>
                <person name="Zhu X."/>
                <person name="Hedgecock E.M."/>
            </authorList>
            <locator>14(5):76</locator>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <id>Q23356-4</id>
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            <sequence type="described" ref="VSP_014010 VSP_014012"/>
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            <sequence type="described" ref="VSP_014011 VSP_014012"/>
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        <name type="primary">mig-15</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="1998-08" db="EMBL/GenBank/DDBJ databases">
            <title>MIG-15, a NIK ortholog of the STE20 family of serine/threonine protein kinases, is involved in cell migration and signal transduction in C. elegans.</title>
            <authorList>
                <person name="Zhu X."/>
                <person name="Acharya P."/>
                <person name="Hedgecock E.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 369-1096 (ISOFORM C)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Curr. Biol." volume="12" first="622" last="631">
            <title>A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans.</title>
            <authorList>
                <person name="Poinat P."/>
                <person name="De Arcangelis A."/>
                <person name="Sookhareea S."/>
                <person name="Zhu X."/>
                <person name="Hedgecock E.M."/>
                <person name="Labouesse M."/>
                <person name="Georges-Labouesse E."/>
            </authorList>
            <dbReference type="PubMed" id="11967148"/>
            <dbReference type="DOI" id="10.1016/S0960-9822(02)00764-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Dev. Biol." volume="368" first="404" last="414">
            <title>mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites.</title>
            <authorList>
                <person name="Martynovsky M."/>
                <person name="Wong M.C."/>
                <person name="Byrd D.T."/>
                <person name="Kimble J."/>
                <person name="Schwarzbauer J.E."/>
            </authorList>
            <dbReference type="PubMed" id="22732572"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2012.06.011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="online journal article" date="1997" name="Worm Breeder's Gazette">
            <title>mig-15 encodes a novel Ser/Thr protein kinase of the Ste-20/p65PAK family.</title>
            <authorList>
                <person name="Zhu X."/>
                <person name="Hedgecock E.M."/>
            </authorList>
            <locator>14(5):76</locator>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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            <id>Q23356-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_014012 VSP_014011"/>
        </isoform>
        <isoform>
            <id>Q23356-2</id>
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            <sequence type="described" ref="VSP_014012"/>
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            <id>Q23356-1</id>
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        <isoform>
            <id>Q23356-4</id>
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    <accession>Q23356-4</accession>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="1998-08" db="EMBL/GenBank/DDBJ databases">
            <title>MIG-15, a NIK ortholog of the STE20 family of serine/threonine protein kinases, is involved in cell migration and signal transduction in C. elegans.</title>
            <authorList>
                <person name="Zhu X."/>
                <person name="Acharya P."/>
                <person name="Hedgecock E.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 369-1096 (ISOFORM C)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Curr. Biol." volume="12" first="622" last="631">
            <title>A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans.</title>
            <authorList>
                <person name="Poinat P."/>
                <person name="De Arcangelis A."/>
                <person name="Sookhareea S."/>
                <person name="Zhu X."/>
                <person name="Hedgecock E.M."/>
                <person name="Labouesse M."/>
                <person name="Georges-Labouesse E."/>
            </authorList>
            <dbReference type="PubMed" id="11967148"/>
            <dbReference type="DOI" id="10.1016/S0960-9822(02)00764-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Dev. Biol." volume="368" first="404" last="414">
            <title>mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites.</title>
            <authorList>
                <person name="Martynovsky M."/>
                <person name="Wong M.C."/>
                <person name="Byrd D.T."/>
                <person name="Kimble J."/>
                <person name="Schwarzbauer J.E."/>
            </authorList>
            <dbReference type="PubMed" id="22732572"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2012.06.011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="online journal article" date="1997" name="Worm Breeder's Gazette">
            <title>mig-15 encodes a novel Ser/Thr protein kinase of the Ste-20/p65PAK family.</title>
            <authorList>
                <person name="Zhu X."/>
                <person name="Hedgecock E.M."/>
            </authorList>
            <locator>14(5):76</locator>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q23356-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_014012"/>
        </isoform>
        <isoform>
            <id>Q23356-3</id>
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            <sequence type="described" ref="VSP_014012 VSP_014011"/>
        </isoform>
        <isoform>
            <id>Q23356-1</id>
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            <sequence type="displayed"/>
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        <isoform>
            <id>Q23356-4</id>
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    </comment>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
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        <submittedName>
            <fullName evidence="8">TMEM9 protein</fullName>
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        <name evidence="8" type="ORF">CELE_R12C12.6</name>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD72325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040797.1">
        <property type="nucleotide sequence ID" value="NM_001047332.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6Y3"/>
    <dbReference type="SMR" id="Q2L6Y3"/>
    <dbReference type="GeneID" id="187840"/>
    <dbReference type="UCSC" id="R12C12.6a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020026"/>
    <dbReference type="CTD" id="187840"/>
    <dbReference type="WormBase" id="R12C12.6b">
        <property type="protein sequence ID" value="CE39619"/>
        <property type="gene ID" value="WBGene00020026"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093267_0_0_1"/>
    <dbReference type="OrthoDB" id="10059035at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020026">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6Y3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008853">
        <property type="entry name" value="TMEM9/TMEM9B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13064:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13064">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05434">
        <property type="entry name" value="Tmemb_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD72325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="R12C12.6b"/>
        </source>
    </evidence>
    <sequence length="128" mass="14719" checksum="7CBD8BE702AB3C13" modified="2006-02-21" version="1">MDAFLANCDCRYESRNTVLLKVVVIFVICVIAVLTGYMVFLMCLDPMLRKKRLSISYQQHNDEMEDNIFAAAPSTDDESSSASNSMDTQGTTRARSNVLGRVEAEQNRWMKKVEEQRRNIFEDHTMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6Y4</accession>
    <name>Q2L6Y4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="5">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">ogt-1</name>
        <name evidence="14" type="ORF">CELE_K04G7.3</name>
        <name evidence="16" type="ORF">K04G7.3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="5"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040861.1">
        <property type="nucleotide sequence ID" value="NM_001047396.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6Y4"/>
    <dbReference type="SMR" id="Q2L6Y4"/>
    <dbReference type="PeptideAtlas" id="Q2L6Y4"/>
    <dbReference type="GeneID" id="176000"/>
    <dbReference type="UCSC" id="K04G7.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003858"/>
    <dbReference type="CTD" id="176000"/>
    <dbReference type="WormBase" id="K04G7.3b">
        <property type="protein sequence ID" value="CE39588"/>
        <property type="gene ID" value="WBGene00003858"/>
        <property type="gene designation" value="ogt-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001721_1_0_1"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003858">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6Y4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016262">
        <property type="term" value="F:protein N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040024">
        <property type="term" value="P:dauer larval development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006112">
        <property type="term" value="P:energy reserve metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.150:FF:000003">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000013">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000019">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000001">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000012">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="13">
        <location>
            <begin position="402"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD61615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="K04G7.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="Q2L6Y4"/>
        </source>
    </evidence>
    <sequence length="973" mass="108957" checksum="102031BE8C6AFF2C" modified="2006-02-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6Y5</accession>
    <name>Q2L6Y5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">sma-4</name>
        <name evidence="4" type="ORF">CELE_R12B2.1</name>
        <name evidence="6" type="ORF">R12B2.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040865.1">
        <property type="nucleotide sequence ID" value="NM_001047400.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6Y5"/>
    <dbReference type="SMR" id="Q2L6Y5"/>
    <dbReference type="GeneID" id="175815"/>
    <dbReference type="UCSC" id="R12B2.1a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004858"/>
    <dbReference type="CTD" id="175815"/>
    <dbReference type="WormBase" id="R12B2.1b">
        <property type="protein sequence ID" value="CE39618"/>
        <property type="gene ID" value="WBGene00004858"/>
        <property type="gene designation" value="sma-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026736_1_2_1"/>
    <dbReference type="OrthoDB" id="5875866at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004858">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6Y5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040024">
        <property type="term" value="P:dauer larval development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045138">
        <property type="term" value="P:nematode male tail tip morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045793">
        <property type="term" value="P:positive regulation of cell size"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046622">
        <property type="term" value="P:positive regulation of organ growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF45">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MH2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD73314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="R12B2.1b"/>
        </source>
    </evidence>
    <sequence length="189" mass="21186" checksum="461185C6BC1DA366" modified="2006-02-21" version="1">MDPHGENEGRLCLGALSNVHRTEASEKARIHIGRGVELTAHADGNISITSNCKIFVRSGYLDYTHGSEYSSKAHRFTPNESSFTVFDIRWAYMQMLRRSRSSNEAVRAQAAAVAGYAPMSVMPAIMPDSGVDRMRRDFCTIAISFVKAWGDVYQRKTIKETPCWIEVTLHRPLQILDQLLKNSSQFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-08-02" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q4JFH6</accession>
    <name>Q4JFH6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">spp-10</name>
        <name evidence="7" type="ORF">C28C12.7</name>
        <name evidence="5" type="ORF">CELE_C28C12.7</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD64008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741466.1">
        <property type="nucleotide sequence ID" value="NM_171400.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4JFH6"/>
    <dbReference type="SMR" id="Q4JFH6"/>
    <dbReference type="PeptideAtlas" id="Q4JFH6"/>
    <dbReference type="GeneID" id="177651"/>
    <dbReference type="UCSC" id="C28C12.7a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004995"/>
    <dbReference type="CTD" id="177651"/>
    <dbReference type="WormBase" id="C28C12.7a">
        <property type="protein sequence ID" value="CE29486"/>
        <property type="gene ID" value="WBGene00004995"/>
        <property type="gene designation" value="spp-10"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1171545_0_0_1"/>
    <dbReference type="OrthoDB" id="69496at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004995">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q4JFH6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004239044" evidence="3">
        <location>
            <begin position="17"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="4">
        <location>
            <begin position="34"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="4">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD64008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C28C12.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q4JFH6"/>
        </source>
    </evidence>
    <sequence length="238" mass="27291" checksum="828EF6D21EA03866" modified="2005-08-02" version="1">MKYFILTLAVLGSTLAYSKQNMLDTNRVQAEVIENSSCEECENVIKRISEAAKDPKKIEELKIVLGMMCRETSYADECRLFVSQLDKFIDKLQPFLKNPHAVCTRLHICSNKKIDSFRRILLEFAKRAQKTFDAPAIVCDECQFVVKELKTVVEDKKSQAEARDFLRENVCKSLGQYRGFCDLVVDEYLPQFIQELDAILQDPHQVCVDIKACNSASAQGLKARKYVGILGYFQRHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-08-02" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q4JFH7</accession>
    <name>Q4JFH7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUP50 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_ZK470.2</name>
        <name evidence="2 4" type="ORF">ZK470.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4JFH7"/>
    <dbReference type="UCSC" id="ZK470.2c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022745"/>
    <dbReference type="WormBase" id="ZK470.2b">
        <property type="protein sequence ID" value="CE05087"/>
        <property type="gene ID" value="WBGene00022745"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1070532_0_0_1"/>
    <dbReference type="OrthoDB" id="5824236at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022745">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q4JFH7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD69106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZK470.2b"/>
        </source>
    </evidence>
    <sequence length="78" mass="8323" checksum="2957EC59A092D42C" modified="2005-08-02" version="1">MSVATATMPQQQNNFAQTLSQSSSTASAPAPTSAPVTTPAPGSRGAALFGGVFHRGFFSKPVERTEEENYRYLMALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q7K742</accession>
    <name>Q7K742_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ddl-3</name>
        <name evidence="8" type="ORF">CELE_Y54G11A.8</name>
        <name evidence="10" type="ORF">Y54G11A.8</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TTC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAE46690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022476.1">
        <property type="nucleotide sequence ID" value="NM_001027305.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7K742"/>
    <dbReference type="SMR" id="Q7K742"/>
    <dbReference type="PeptideAtlas" id="Q7K742"/>
    <dbReference type="GeneID" id="175087"/>
    <dbReference type="UCSC" id="Y54G11A.8a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013217"/>
    <dbReference type="CTD" id="175087"/>
    <dbReference type="WormBase" id="Y54G11A.8b">
        <property type="protein sequence ID" value="CE35682"/>
        <property type="gene ID" value="WBGene00013217"/>
        <property type="gene designation" value="ddl-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061872_0_0_1"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013217">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7K742">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001126">
        <property type="entry name" value="Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002247">
        <property type="entry name" value="Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040395">
        <property type="entry name" value="TTC19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143:SF6">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE46690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y54G11A.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q7K742"/>
        </source>
    </evidence>
    <sequence length="395" mass="45174" checksum="D90E121F84F80C10" modified="2004-07-05" version="1">MLPSMSKLCTSTVRPVAAAFSTGTTRQHHSSGRSRQQHHRHGGSGGKTNGGGRWSYGKSAATGGTTVLALSWMTTIKDVLGIEKVQLDADPLKEKVKQSWLYRKRRQYDDAIQVLQLALEEAEERKEDMPITRVYDEMANTFYEKMNLDEADKYFRIVIQRLVQLHGKKDFDPEFIGVSLKLADILAHRGDLESAESGFKHCVRRQMKVMEEHMKKFSVAHGALVEDRHTVDTFGPMYTDPIALFGMTLEAYANFLINYCGETRMAEVEEYIDEVMKISYQIYGASSAHTINMLNNFGATLVLKNRFELAKKYLAIGVDRILYVNECAHMLPGYYCNYAESLFHTGQKNEALEFARKAVQMSRSGDDRVRHYTQNFLNDLEKDINRGKPKSWWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXR6</accession>
    <name>Q8MXR6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">sqd-1</name>
        <name evidence="7" type="ORF">CELE_Y73B6BL.6</name>
        <name evidence="9" type="ORF">Y73B6BL.6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD74155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380079.1">
        <property type="nucleotide sequence ID" value="NM_001392316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXR6"/>
    <dbReference type="SMR" id="Q8MXR6"/>
    <dbReference type="IntAct" id="Q8MXR6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q8MXR6"/>
    <dbReference type="GeneID" id="177392"/>
    <dbReference type="UCSC" id="Y73B6BL.6a.7">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022235"/>
    <dbReference type="CTD" id="177392"/>
    <dbReference type="WormBase" id="Y73B6BL.6a">
        <property type="protein sequence ID" value="CE29008"/>
        <property type="gene ID" value="WBGene00022235"/>
        <property type="gene designation" value="sqd-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_1_1_1"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022235">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXR6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21608">
        <property type="entry name" value="RRM2_NsCP33_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001007">
        <property type="entry name" value="Homologous to Drosophila SQD (Squid) protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001014">
        <property type="entry name" value="Homologous to Drosophila SQD (Squid) protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048289">
        <property type="entry name" value="RRM2_NsCP33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF10">
        <property type="entry name" value="RNA-BINDING PROTEIN SQUID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD74155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y73B6BL.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MXR6"/>
        </source>
    </evidence>
    <sequence length="305" mass="33467" checksum="3B005BF7D73877D6" modified="2002-10-01" version="1">MEATDNKINGNASETIKENGHSTKGNEDKKIFVGGISPEVNNEDLSSHFTQYGEVAQAQVKYDRTNGRSRGFAFVEFTTGEGCKLALAAREQTIKGKSVEVKPAKSRENKKVFVGGLPSDYSEQDLRSHFEQFGKVDDIEWPFDKQTKARRNFAFIVFEEEESADKASSQTKQTFGTRECDVKKAVPQGKRFPGAQGRMPGGRGMYGGRGGNNNSGWYAGWGQIGAMPYGATGAAWGDWYGNGYYGQQGAAHHNNSGSSQGYGSGYQRNNSGFDYQQAQGARQGNNGQPRFQQQPQQQTAQAQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="183" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXS0</accession>
    <name>Q8MXS0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 23" type="primary">mca-3</name>
        <name evidence="21" type="ORF">CELE_Y67D8C.10</name>
        <name evidence="23" type="ORF">Y67D8C.10</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD74100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370848.1">
        <property type="nucleotide sequence ID" value="NM_001383061.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXS0"/>
    <dbReference type="SMR" id="Q8MXS0"/>
    <dbReference type="PeptideAtlas" id="Q8MXS0"/>
    <dbReference type="GeneID" id="177089"/>
    <dbReference type="UCSC" id="Y67D8C.10c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003153"/>
    <dbReference type="CTD" id="177089"/>
    <dbReference type="WormBase" id="Y67D8C.10c">
        <property type="protein sequence ID" value="CE31664"/>
        <property type="gene ID" value="WBGene00003153"/>
        <property type="gene designation" value="mca-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003153">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXS0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="entry name" value="ATPase-IIB_Ca"/>
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        <property type="entry name" value="ATPase_P-type"/>
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        <property type="entry name" value="Hydrolase_3"/>
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        <property type="entry name" value="CATATPASE"/>
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    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
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    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="330"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="373"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="823"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="854"/>
            <end position="872"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="900"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="938"/>
            <end position="956"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="976"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1041"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1117"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1124"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCD74100.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WormBase" id="Y67D8C.10c"/>
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    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MXS0"/>
        </source>
    </evidence>
    <sequence length="1137" mass="124597" checksum="4F2C79A7E225EA59" modified="2002-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXS6</accession>
    <name>Q8MXS6_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rbm-39</name>
        <name evidence="7" type="ORF">CELE_Y55F3AM.3</name>
        <name evidence="9" type="ORF">Y55F3AM.3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD74061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001380075.1">
        <property type="nucleotide sequence ID" value="NM_001392253.1"/>
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        <property type="organism name" value="c. elegans"/>
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        <property type="protein sequence ID" value="CE31656"/>
        <property type="gene ID" value="WBGene00021921"/>
        <property type="gene designation" value="rbm-39"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020551_5_1_1"/>
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        <property type="component" value="Chromosome IV"/>
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    <dbReference type="Bgee" id="WBGene00021921">
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd12283">
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    <dbReference type="CDD" id="cd12285">
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        <property type="entry name" value="RNA Binding Motif protein homolog"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA-binding protein 39 isoform X2"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBM39_linker"/>
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        <property type="entry name" value="RRM_euk-type"/>
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        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
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    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="127"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD74061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y55F3AM.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MXS6"/>
        </source>
    </evidence>
    <sequence length="435" mass="47532" checksum="9FFE26FBF21F3114" modified="2002-10-01" version="1">MPFNPRHSPPKNAKLELTAEERDQRTLLIMQIARDTRPRDLEEFFSAVGAVRDVRIITDSRTGRSKGICYVEFWDEESVPLGLALNGQRLMGAPLQIQRTCAERNRAANSSVASTLGFVAPGNKGPTHVLVENLHPKIDEKMIRDIFESFGRIEKIDLEVDSNRENRGFATITFRNADDAQKSCEQLNNFELAGRCIRLSIKQESQAPAVKKEEASIHQRSLDDVGDRQGFSLGAGGRQQLMAKLAQGTGSGMELTASAQMAAQHAGHSQIPSIATQCFLLSNMFDPSKETEPAWDHDIREDVIEQCLAHGGALHVFVDKGSEQGNVYVKCPSIVIAHQAVSALHGRWFSGKVITANYVPVNSYHDLFPDAVHARIVLTTRGAAPVVPIVPMVPVVPPQGIANGYGAYGMMAPAHGAPPPPPPQQQGQYGGYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXT2</accession>
    <name>Q8MXT2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y38C1AA.1</name>
        <name evidence="4 6" type="ORF">Y38C1AA.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD70244.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXT2"/>
    <dbReference type="SMR" id="Q8MXT2"/>
    <dbReference type="UCSC" id="Y38C1AA.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021394"/>
    <dbReference type="WormBase" id="Y38C1AA.1b">
        <property type="protein sequence ID" value="CE52353"/>
        <property type="gene ID" value="WBGene00021394"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2335523_0_0_1"/>
    <dbReference type="OrthoDB" id="44277at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021394">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXT2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753:SF14">
        <property type="entry name" value="MONOACYLGLYCEROL_DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD70244.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y38C1AA.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MXT2"/>
        </source>
    </evidence>
    <sequence length="366" mass="42403" checksum="2097AFC1CC79F17C" modified="2017-12-20" version="2">MFQWLHETILNWAHAIYEFVPEYLLWLLLPFFILFIFPIFLVFFIYGCVIFVHIYGHRHQIREAYHTSYWEGARVAIASFWDGVGNVWHGYELRGIENVPDEGSALFIYYHGCLPLDVYYLISKLVIHKNRSLHCVGDKFIFKIPGWRPLCKLFSITSGTVEECTEELKEGNLLCIAPGGVREALFSDPNVYDILWGKRLGFAKVIIGSKTPVIPMFTENCRESFRTPEWGRSFFRWIYEKTKIPLCPIYGGFPVKMITHLGKPIYFDFDTVTPEEVRKTVKREIRMMIKEHQRLPGSVWRGIAQRWSSTSSKKKNSDEPEQAELLQRNGAGTTSPTSDSEDIVVLRRDRSGVEDDDDEVDELGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXU2</accession>
    <name>Q8MXU2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">mgl-3</name>
        <name evidence="14" type="ORF">CELE_Y4C6A.2</name>
        <name evidence="16" type="ORF">Y4C6A.2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD74029.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741400.2">
        <property type="nucleotide sequence ID" value="NM_171341.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXU2"/>
    <dbReference type="SMR" id="Q8MXU2"/>
    <dbReference type="GeneID" id="177327"/>
    <dbReference type="UCSC" id="Y4C6A.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021152"/>
    <dbReference type="CTD" id="177327"/>
    <dbReference type="WormBase" id="Y4C6A.2a">
        <property type="protein sequence ID" value="CE49472"/>
        <property type="gene ID" value="WBGene00021152"/>
        <property type="gene designation" value="mgl-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005389_0_0_1"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021152">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXU2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15934">
        <property type="entry name" value="7tmC_mGluRs_group2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000008">
        <property type="entry name" value="Metabotropic GLutamate receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000377">
        <property type="entry name" value="Metabotropic GLutamate receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="577"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="765"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="793"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="577"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="863"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD74029.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="Y4C6A.2a"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112390" checksum="4B94AE386F7A532B" modified="2014-02-19" version="2"> </sequence>
</entry>
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    <accession>Q8MXU9</accession>
    <name>Q8MXU9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_K08D12.3</name>
        <name evidence="4 6" type="ORF">K08D12.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD72802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXU9"/>
    <dbReference type="PeptideAtlas" id="Q8MXU9"/>
    <dbReference type="UCSC" id="K08D12.3a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019537"/>
    <dbReference type="WormBase" id="K08D12.3b">
        <property type="protein sequence ID" value="CE31712"/>
        <property type="gene ID" value="WBGene00019537"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3261022_0_0_1"/>
    <dbReference type="OrthoDB" id="5870588at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019537">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXU9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000083">
        <property type="entry name" value="Protein CBG13587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD72802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="K08D12.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MXU9"/>
        </source>
    </evidence>
    <sequence length="42" mass="4308" checksum="37671D6B7A21A567" modified="2002-10-01" version="1">MSDRNCYKCQQPGHISRNCPNGESDGGRRGGGGGGVVLNLGC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-05-03" modified="2026-01-28" version="167" xmlns="https://uniprot.org/uniprot">
    <accession>Q8WQC9-2</accession>
    <name>DNM1L_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform a of Dynamin-1-like protein drp-1</fullName>
            <ecNumber evidence="1">3.6.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 7">Dynamin-related protein drp-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">drp-1</name>
        <name evidence="7" type="ORF">T12E12.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="1999" name="Mol. Cell" volume="4" first="815" last="826">
            <title>C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane.</title>
            <authorList>
                <person name="Labrousse A.M."/>
                <person name="Zappaterra M.D."/>
                <person name="Rube D.A."/>
                <person name="van der Bliek A.M."/>
            </authorList>
            <dbReference type="PubMed" id="10619028"/>
            <dbReference type="DOI" id="10.1016/S1097-2765(00)80391-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF LYS-40; VAL-43 AND THR-61</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2005" name="Nature" volume="433" first="754" last="760">
            <title>DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans.</title>
            <authorList>
                <person name="Jagasia R."/>
                <person name="Grote P."/>
                <person name="Westermann B."/>
                <person name="Conradt B."/>
            </authorList>
            <dbReference type="PubMed" id="15716954"/>
            <dbReference type="DOI" id="10.1038/nature03316"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF LYS-40</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2008" name="Mol. Cell" volume="31" first="586" last="597">
            <title>Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.</title>
            <authorList>
                <person name="Breckenridge D.G."/>
                <person name="Kang B.H."/>
                <person name="Kokel D."/>
                <person name="Mitani S."/>
                <person name="Staehelin L.A."/>
                <person name="Xue D."/>
            </authorList>
            <dbReference type="PubMed" id="18722182"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2008.07.015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ASP-118</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2009" name="Curr. Biol." volume="19" first="768" last="773">
            <title>Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Breckenridge D.G."/>
                <person name="Kang B.H."/>
                <person name="Xue D."/>
            </authorList>
            <dbReference type="PubMed" id="19327994"/>
            <dbReference type="DOI" id="10.1016/j.cub.2009.03.022"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="3" key="6">
        <citation type="journal article" date="2011" name="Aging Cell" volume="10" first="724" last="728">
            <title>The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity.</title>
            <authorList>
                <person name="Yang C.C."/>
                <person name="Chen D."/>
                <person name="Lee S.S."/>
                <person name="Walter L."/>
            </authorList>
            <dbReference type="PubMed" id="21463460"/>
            <dbReference type="DOI" id="10.1111/j.1474-9726.2011.00711.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="7">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="E813" last="E822">
            <title>A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lu Y."/>
                <person name="Rolland S.G."/>
                <person name="Conradt B."/>
            </authorList>
            <dbReference type="PubMed" id="21949250"/>
            <dbReference type="DOI" id="10.1073/pnas.1103218108"/>
        </citation>
        <scope>INTERACTION WITH CED-9</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF SER-41</scope>
    </reference>
    <reference evidence="3" key="8">
        <citation type="journal article" date="2021" name="J. Cell Biol." volume="220" first="0" last="0">
            <title>Autophagy facilitates mitochondrial rebuilding after acute heat stress via a DRP-1-dependent process.</title>
            <authorList>
                <person name="Chen Y."/>
                <person name="Leboutet R."/>
                <person name="Largeau C."/>
                <person name="Zentout S."/>
                <person name="Lefebvre C."/>
                <person name="Delahodde A."/>
                <person name="Culetto E."/>
                <person name="Legouis R."/>
            </authorList>
            <dbReference type="PubMed" id="33734301"/>
            <dbReference type="DOI" id="10.1083/jcb.201909139"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q8WQC9-2</id>
            <name evidence="6">a</name>
            <sequence type="described" ref="VSP_061809"/>
        </isoform>
        <isoform>
            <id>Q8WQC9-1</id>
            <name evidence="7">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001023375.1">
        <property type="nucleotide sequence ID" value="NM_001028204.4"/>
    </dbReference>
    <dbReference type="WormBase" id="T12E12.4a">
        <property type="protein sequence ID" value="CE30172"/>
        <property type="gene ID" value="WBGene00001093"/>
        <property type="gene designation" value="drp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="10619028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAD49861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T12E12.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T12E12.4b"/>
        </source>
    </evidence>
    <sequence length="705" mass="79265" checksum="77AECCACB4E61A33" modified="2002-03-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q95Q18-2</accession>
    <name>LACB2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Beta-lactamase-like protein 2 homolog</fullName>
            <ecNumber>3.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">Y53F4B.39</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95Q18-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95Q18-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_030694"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.-.-.-"/>
    <dbReference type="RefSeq" id="NP_001122663.1">
        <property type="nucleotide sequence ID" value="NM_001129191.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y53F4B.39b">
        <property type="protein sequence ID" value="CE41183"/>
        <property type="gene ID" value="WBGene00013176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="329" mass="36987" checksum="C51F5AB2ADDE3C74" modified="2001-12-01" version="1">MTAYVGRAWTMLRFYTDFAYAGVAYLVNSKAHRAMPSLTHVEPIEKLSDAVTRILGHNPGPFTLQGTNTYLLGTGAKKILVDTGEPNVTEYISALKSVLASTNSHIEYIVITHWHGDHVGGIDNITDEILDKKKIPIYKMKRDKDEGVERFHYVDDGFEVAVDGATLKLIATPGHTADHFSLWLQEERALFSGDCILGEGTTVFEDLHDYMTSLQKIKDLNATRIYPGHGPVIDKVVEKVDEYIEHRMKREREIIKVLKEHEEITSMDVTNQVYADSPWAVRLAALNNVKLVLKKLCKDGVVENPHFETFKWIGGSSSGEEKKNESSNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2026-01-28" version="187" xmlns="https://uniprot.org/uniprot">
    <accession>Q968Y9-3</accession>
    <name>INSR_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Insulin-like receptor</fullName>
            <shortName evidence="1">IR</shortName>
            <ecNumber>2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Abnormal dauer formation protein 2</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">Insulin-like receptor subunit alpha</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Insulin-like receptor subunit beta</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="primary">daf-2</name>
        <name evidence="6" type="ORF">Y55D5A.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1997" name="Science" volume="277" first="942" last="946">
            <title>daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kimura K.D."/>
                <person name="Tissenbaum H.A."/>
                <person name="Liu Y."/>
                <person name="Ruvkun G."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.277.5328.942"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-401; CYS-469; PRO-470; SER-573; ASP-648; ASP-1374; PRO-1434 AND PRO-1465</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
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    </reference>
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            <dbReference type="PubMed" id="9790527"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-1465</scope>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ALA-580 AND PRO-1465</scope>
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        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-383</scope>
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            <dbReference type="PubMed" id="16950159"/>
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        <scope>MUTAGENESIS OF GLY-383; ASP-1374 AND PRO-1465</scope>
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            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
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        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-364; ASN-453; ASN-696; ASN-1017 AND ASN-1078</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
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                <person name="Evans E.A."/>
                <person name="Chen W.C."/>
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            <dbReference type="PubMed" id="18782349"/>
            <dbReference type="DOI" id="10.1111/j.1474-9726.2008.00435.x"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-1465</scope>
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            <dbReference type="PubMed" id="18436204"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2008.03.019"/>
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        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-383; GLY-547; CYS-1045; PRO-1434 AND PRO-1465</scope>
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            <dbReference type="PubMed" id="18832074"/>
            <dbReference type="DOI" id="10.1101/gad.478408"/>
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        <scope>ACTIVITY REGULATION</scope>
        <scope>INTERACTION WITH SHC-1</scope>
    </reference>
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            <dbReference type="PubMed" id="18245374"/>
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        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-146 AND PRO-1465</scope>
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        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF PRO-1465</scope>
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        <scope>MUTAGENESIS OF PRO-1465</scope>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF PRO-1465</scope>
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        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF PRO-1465</scope>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-1434 AND PRO-1465</scope>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF SER-573</scope>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH DAF-18</scope>
        <scope>MUTAGENESIS OF PRO-1465</scope>
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        <scope>FUNCTION (ISOFORMS A AND C)</scope>
        <scope>SUBCELLULAR LOCATION (ISOFORM C)</scope>
        <scope>INTERACTION WITH CASY-1 (ISOFORM C)</scope>
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            <dbReference type="PubMed" id="26552888"/>
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        <scope>MUTAGENESIS OF PRO-1465</scope>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-1465</scope>
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                <person name="De Magalhaes Filho C.D."/>
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        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF PRO-1465</scope>
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    <comment type="function">
        <text evidence="2">Required for taste avoidance learning in axons of ASER gustatory neurons.</text>
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    <comment type="subunit">
        <text evidence="2">Interacts with casy-1; promoting axonal localization.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
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        <event type="alternative splicing"/>
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            <id>Q9GQ60-2</id>
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            <id>Q9GQ60-1</id>
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    <proteinExistence type="predicted"/>
    <sequence length="278" mass="30586" checksum="77CED956E4B94923" modified="2012-02-22" version="2">MSRSIDSSSSRMLPSPITNFVTPSSSFSSHQMHDIYSLAASYLQAPPPPYTPTTAFHPHNAHQLLLLHNMTAAVQTPEDPDIDVVGLADTTNLVSLNDKEDEEKLDQTTESEESDRISISTTEECPLDLTFKPTSLDSPTSSTFIPLRPSVIIDHHIPKPHTSVRRSMSSVSSSASSTQEEVAAHFRRSLSGKWPKRCKVNSEEARNSPLRRRPSFNTHTSVSSLSVHSVSPTPPVTSSAQTIIVNNHCSDTTLSVADHFRRALLGKGLFDFQRKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N3F4</accession>
    <name>Q9N3F4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">vbh-1</name>
        <name evidence="14" type="ORF">CELE_Y54E10A.9</name>
        <name evidence="16" type="ORF">Y54E10A.9</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD72826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491113.1">
        <property type="nucleotide sequence ID" value="NM_058712.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N3F4"/>
    <dbReference type="SMR" id="Q9N3F4"/>
    <dbReference type="DIP" id="DIP-24878N"/>
    <dbReference type="PeptideAtlas" id="Q9N3F4"/>
    <dbReference type="GeneID" id="171888"/>
    <dbReference type="UCSC" id="Y54E10A.9a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006888"/>
    <dbReference type="CTD" id="171888"/>
    <dbReference type="WormBase" id="Y54E10A.9a">
        <property type="protein sequence ID" value="CE24451"/>
        <property type="gene ID" value="WBGene00006888"/>
        <property type="gene designation" value="vbh-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006888">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N3F4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="151"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="352"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="578"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD72826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="Y54E10A.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N3F4"/>
        </source>
    </evidence>
    <sequence length="641" mass="69219" checksum="D7C0181C72F4C206" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="170" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N3F8</accession>
    <name>Q9N3F8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">ral-1</name>
        <name evidence="13" type="ORF">CELE_Y53G8AR.3</name>
        <name evidence="15" type="ORF">Y53G8AR.3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254867.1">
        <property type="nucleotide sequence ID" value="NM_001267938.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N3F8"/>
    <dbReference type="SMR" id="Q9N3F8"/>
    <dbReference type="GeneID" id="175433"/>
    <dbReference type="UCSC" id="Y53G8AR.3">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021811"/>
    <dbReference type="CTD" id="175433"/>
    <dbReference type="WormBase" id="Y53G8AR.3a">
        <property type="protein sequence ID" value="CE25424"/>
        <property type="gene ID" value="WBGene00021811"/>
        <property type="gene designation" value="ral-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="PhylomeDB" id="Q9N3F8"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021811">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N3F8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040026">
        <property type="term" value="P:positive regulation of vulval development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd04139">
        <property type="entry name" value="RalA_RalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000203">
        <property type="entry name" value="Putative ras-related protein ral-a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD73808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="Y53G8AR.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N3F8"/>
        </source>
    </evidence>
    <sequence length="213" mass="23970" checksum="1C7D10A511B5912E" modified="2000-10-01" version="1">MASKKASGTLPPQQQVVHKVIMVGTGGVGKSALTLQFMYDEFVEEYEPTKADSYRKKVVLDGEECSIDILDTAGQEDYSAIRDNYYRSGEGFICVFSILDMESFEATNEFREQILRVKNSDSSVPIVLVGNKGDMRDQRVVSAELCRQRAEQWGCHYVETSAKRRENVDKVFYDLMREMKRRKGGSQAQTGIDASASSGRKKRSGIKKHCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N3M7</accession>
    <name>Q9N3M7_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y48G9A.6</name>
        <name evidence="3 5" type="ORF">Y48G9A.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD67068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_497503.2">
        <property type="nucleotide sequence ID" value="NM_065102.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N3M7"/>
    <dbReference type="PaxDb" id="6239-Y48G9A.6"/>
    <dbReference type="GeneID" id="190053"/>
    <dbReference type="UCSC" id="Y48G9A.6">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00021700"/>
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    <dbReference type="WormBase" id="Y48G9A.6a">
        <property type="protein sequence ID" value="CE35094"/>
        <property type="gene ID" value="WBGene00021700"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_967193_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021700">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058721">
        <property type="entry name" value="NTF2_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33940:SF1">
        <property type="entry name" value="APOLIPOPHORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33940">
        <property type="entry name" value="PROTEIN CBG13625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26530">
        <property type="entry name" value="NTF2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013379849" evidence="1">
        <location>
            <begin position="16"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="2">
        <location>
            <begin position="110"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD67068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y48G9A.6a"/>
        </source>
    </evidence>
    <sequence length="288" mass="33450" checksum="E20D1745A647EFB7" modified="2003-10-01" version="2">MRLQVLLLLAVGSAASDFGSPLVAPISTSEPWDDTVLKIREFANIFTAALRTRSWYKIEKFFDKDFYMLCLADDRKTVMRRDERCSPEIPSNSIHHKTALASAEQLTTLEHITKFLELFEAAIATRDWYQIEKRFGKYFFLERCWIDNHYTLRTSRTEFITMLTNIPRNNDVSFDLLSYHGEVYGGRLTDSISIEVTISGIMATPLRFKFMFSHRGYLLEIGHRIECEYVRFADDENYDVGHEFAVAPASSGALSPTVERINEFLESFKAAIETRDWYQIEKHFRSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N3M9</accession>
    <name>Q9N3M9_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">CsbD family protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y48G9A.7</name>
        <name evidence="1 3" type="ORF">Y48G9A.7</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD67069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N3M9"/>
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    <dbReference type="GeneID" id="190054"/>
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        <property type="organism name" value="c. elegans"/>
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    <dbReference type="CTD" id="190054"/>
    <dbReference type="WormBase" id="Y48G9A.7a">
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        <property type="gene ID" value="WBGene00021701"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2656698_0_0_1"/>
    <dbReference type="PhylomeDB" id="Q9N3M9"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021701">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD67069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y48G9A.7a"/>
        </source>
    </evidence>
    <sequence length="76" mass="7932" checksum="246E5BA49F7E6558" modified="2000-10-01" version="1">MENKTIQLFGNITGGPIELHSQTGSRRRRDTVENAGKSAWDTAGDVGKSVIDTVENAGAAVKNGASDLDEKLMGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>U4PDU4</accession>
    <name>U4PDU4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flocculation protein FLO11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F28E10.1</name>
        <name evidence="3 5" type="ORF">F28E10.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH92926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294243.1">
        <property type="nucleotide sequence ID" value="NM_001307314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PDU4"/>
    <dbReference type="SMR" id="U4PDU4"/>
    <dbReference type="GeneID" id="177223"/>
    <dbReference type="AGR" id="WB:WBGene00017900"/>
    <dbReference type="CTD" id="177223"/>
    <dbReference type="WormBase" id="F28E10.1i">
        <property type="protein sequence ID" value="CE48705"/>
        <property type="gene ID" value="WBGene00017900"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864201at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017900">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PDU4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="790"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="950"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1167"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="951"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH92926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F28E10.1i"/>
        </source>
    </evidence>
    <sequence length="1263" mass="142307" checksum="A9DD45F276B0F037" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>U4PDV0</accession>
    <name>U4PDV0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_K09B3.1</name>
        <name evidence="4 6" type="ORF">K09B3.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH92932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PDV0"/>
    <dbReference type="SMR" id="U4PDV0"/>
    <dbReference type="AGR" id="WB:WBGene00019545"/>
    <dbReference type="WormBase" id="K09B3.1c">
        <property type="protein sequence ID" value="CE49064"/>
        <property type="gene ID" value="WBGene00019545"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109952_0_0_1"/>
    <dbReference type="OrthoDB" id="5868945at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019545">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PDV0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDH92932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="K09B3.1c"/>
        </source>
    </evidence>
    <sequence length="121" mass="12356" checksum="4B3A017CADEC40C4" modified="2013-12-11" version="1">MMSGGGGMYGAGGCMDLSPQCSVWASTGQCSTNPMMMRQTCAMSCGTCSTGVGALGSMGSYNPFGGYGGMGYPQAGLLDPLAQFIGRSIYETGILRQPTPSSSSKSIGILTKAKSEQLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>U4PDV5</accession>
    <name>U4PDV5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mog-4</name>
        <name evidence="4" type="ORF">C04H5.6</name>
        <name evidence="2" type="ORF">CELE_C04H5.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH92937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293532.1">
        <property type="nucleotide sequence ID" value="NM_001306603.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PDV5"/>
    <dbReference type="SMR" id="U4PDV5"/>
    <dbReference type="PeptideAtlas" id="U4PDV5"/>
    <dbReference type="GeneID" id="175117"/>
    <dbReference type="AGR" id="WB:WBGene00003392"/>
    <dbReference type="CTD" id="175117"/>
    <dbReference type="WormBase" id="C04H5.6b">
        <property type="protein sequence ID" value="CE48983"/>
        <property type="gene ID" value="WBGene00003392"/>
        <property type="gene designation" value="mog-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_7_1_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003392">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PDV5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH92937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C04H5.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PDV5"/>
        </source>
    </evidence>
    <sequence length="43" mass="4965" checksum="E647C830E8F43886" modified="2013-12-11" version="1">MSEIESGWLLEVAPHYYKGRELEDATNKKMPKNKGKSGKDLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>U4PDW0</accession>
    <name>U4PDW0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SEC63 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CELE_Y54E2A.4</name>
        <name evidence="13 15" type="ORF">Y54E2A.4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDH92943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293536.1">
        <property type="nucleotide sequence ID" value="NM_001306607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PDW0"/>
    <dbReference type="SMR" id="U4PDW0"/>
    <dbReference type="PeptideAtlas" id="U4PDW0"/>
    <dbReference type="GeneID" id="190256"/>
    <dbReference type="AGR" id="WB:WBGene00013189"/>
    <dbReference type="CTD" id="190256"/>
    <dbReference type="WormBase" id="Y54E2A.4c">
        <property type="protein sequence ID" value="CE48569"/>
        <property type="gene ID" value="WBGene00013189"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_2_1_1"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013189">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PDW0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000412">
        <property type="entry name" value="Protein CBG04253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF6">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SEC63" evidence="12">
        <location>
            <begin position="127"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDH92943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="Y54E2A.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="U4PDW0"/>
        </source>
    </evidence>
    <sequence length="476" mass="53929" checksum="B469B0900FE2AB87" modified="2013-12-11" version="1">MMGRAGRPQFDDSAVAVIYVQDAKKTFYKKFLYEPFPVESSLLPVLPNHVNAEISAGTIDSKQAIVEYLSKTYLYRRLFANPNYYGLEEDSEEAMLKFITKIVDDSVAELLASECIHVDSEQDVIKPTPCGRIASVYYLQHETVRFLVKSLHSGCSVENMLKILTDVPEYAEIPVRHNEDLINTELQKKLRIRFSTSVMGTSACKAHLLFQAHFMRTVLPTDYRTDLKSVLDQCIRILQAMREMARLKNWLSATMNIILLQQMCHSARWHDDHPLLCLPHLSHEDARSIGDGMTIPQLQNHLEIEKSTSLDDAKLARRAQKLFRECTKLDEAQSREVLKALCNWPIINMKIMQLVDSRGNCVDIDETKKPVKVTAGEVYKLRIVMERVGPGKNNSSMHLPQWPKPKQAGWIIVVGNVSADMILNTTTVTGSHSTRSTAKLDIRAPATKGNHELAVLILSDCYLGIDQEYTLRLDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>U4PDW4</accession>
    <name>U4PDW4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Yeast DiM Like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">dml-1</name>
        <name evidence="2" type="ORF">CELE_Y54G2A.5</name>
        <name evidence="4" type="ORF">Y54G2A.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH92948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294254.1">
        <property type="nucleotide sequence ID" value="NM_001307325.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PDW4"/>
    <dbReference type="SMR" id="U4PDW4"/>
    <dbReference type="GeneID" id="177071"/>
    <dbReference type="AGR" id="WB:WBGene00021871"/>
    <dbReference type="CTD" id="177071"/>
    <dbReference type="WormBase" id="Y54G2A.5c">
        <property type="protein sequence ID" value="CE48813"/>
        <property type="gene ID" value="WBGene00021871"/>
        <property type="gene designation" value="dml-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1195788_0_0_1"/>
    <dbReference type="OrthoDB" id="5877318at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021871">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PDW4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH92948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y54G2A.5c"/>
        </source>
    </evidence>
    <sequence length="214" mass="22881" checksum="99D2A9E6D09C229E" modified="2013-12-11" version="1">MPAPAVAAQSIGGQILTRAALSVMRQMGMLDGSSAMDDGVEKPKVIDGGRARRVVEEEEPKTVSPMCMEEFRNILQNGVSTGSPCSPRRRASLMAELVGPVPRLELESKFVEPAAPPRKSIPGFMAAPKFASTPKPDGIRRSMVDGSLPTPRRGSLVKQQRAPAIGDVTPMENKASRLRRLKLEETRKSMTGGGGGSGKELNLDISLNSSCGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4PDX1</accession>
    <name>U4PDX1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ashwin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y54G2A.26</name>
        <name evidence="2 4" type="ORF">Y54G2A.26</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH92953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PDX1"/>
    <dbReference type="PeptideAtlas" id="U4PDX1"/>
    <dbReference type="AGR" id="WB:WBGene00021890"/>
    <dbReference type="WormBase" id="Y54G2A.26c">
        <property type="protein sequence ID" value="CE48762"/>
        <property type="gene ID" value="WBGene00021890"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042198_0_0_1"/>
    <dbReference type="OrthoDB" id="5817233at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021890">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PDX1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH92953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y54G2A.26c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PDX1"/>
        </source>
    </evidence>
    <sequence length="326" mass="34624" checksum="89EEC0FDC79B3A24" modified="2013-12-11" version="1">MGISLATVRKCIDMAVDEEVFTRCTDKNLVNLTPSERAEREELLSKLSTVFEDEKSLGAGTAGMTIAEYSPRRSYSNTLLRQSTDDKSSTSSYNANGGEYGGSTETTLLNLDDHSNSSKDYGMTPTTPAAPVASSVTSDLGGGGGQVFEEIGAIGGGMSTESSLDDKSAVKIPKRGRPCKAPGTTATNKSTKRKESQDGGQEVGGPVEDKDDHEKKTEDEDETNEETEKIEVQQADQAEREDDAASSEGTNRSETATPELATDTTAVAKKTRSAAARRKNTKTVDDEFAGATKKKRGSVTAATAGIGGDDENSDHKMVTRARSRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>U4PDX5</accession>
    <name>U4PDX5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y54G2A.45</name>
        <name evidence="1 3" type="ORF">Y54G2A.45</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH92958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PDX5"/>
    <dbReference type="AGR" id="WB:WBGene00044488"/>
    <dbReference type="WormBase" id="Y54G2A.45c">
        <property type="protein sequence ID" value="CE48621"/>
        <property type="gene ID" value="WBGene00044488"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032957_0_0_1"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044488">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PDX5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF10">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH92958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y54G2A.45c"/>
        </source>
    </evidence>
    <sequence length="62" mass="7274" checksum="3C266E5D54341036" modified="2013-12-11" version="1">MYHHRTEVWYNNDMSVGSSYQICPEADGLYCVNQQVDLSWNDHTHYFNTDLNVYGDLGCPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>U4PE86</accession>
    <name>U4PE86_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_K08F11.1</name>
        <name evidence="1 3" type="ORF">K08F11.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PE86"/>
    <dbReference type="AGR" id="WB:WBGene00019541"/>
    <dbReference type="WormBase" id="K08F11.1b">
        <property type="protein sequence ID" value="CE48836"/>
        <property type="gene ID" value="WBGene00019541"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1898091_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019541">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PE86">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="K08F11.1b"/>
        </source>
    </evidence>
    <sequence length="55" mass="6019" checksum="797B8DA2B2C039C8" modified="2013-12-11" version="1">MDRTSMIQVTTDFNAGWVAARNEANVAQLDALRGQADNIDSMAKKCFGRSTAQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>X5LPT9</accession>
    <name>X5LPT9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Afadin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">afd-1</name>
        <name evidence="6" type="ORF">CELE_W03F11.6</name>
        <name evidence="8" type="ORF">W03F11.6</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDO41086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293329.1">
        <property type="nucleotide sequence ID" value="NM_001306400.4"/>
    </dbReference>
    <dbReference type="SMR" id="X5LPT9"/>
    <dbReference type="GeneID" id="171776"/>
    <dbReference type="AGR" id="WB:WBGene00021009"/>
    <dbReference type="CTD" id="171776"/>
    <dbReference type="WormBase" id="W03F11.6f">
        <property type="protein sequence ID" value="CE49723"/>
        <property type="gene ID" value="WBGene00021009"/>
        <property type="gene designation" value="afd-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260541at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021009">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="X5LPT9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15471">
        <property type="entry name" value="Myo5p-like_CBD_afadin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06789">
        <property type="entry name" value="PDZ_AFDN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01782">
        <property type="entry name" value="RA1_Afadin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000237">
        <property type="entry name" value="AFaDin (Actin filament binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000492">
        <property type="entry name" value="AFaDin (Actin filament binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000025">
        <property type="entry name" value="Afadin, adherens junction formation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028842">
        <property type="entry name" value="Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037977">
        <property type="entry name" value="CBD_Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398:SF2">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="4">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="4">
        <location>
            <begin position="217"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="5">
        <location>
            <begin position="612"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="972"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1503"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1214"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1522"/>
            <end position="1544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDO41086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="W03F11.6f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="X5LPT9"/>
        </source>
    </evidence>
    <sequence length="1564" mass="173732" checksum="6BEBDBFA84EE9321" modified="2014-06-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>X5LPW2</accession>
    <name>X5LPW2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y20F4.4</name>
        <name evidence="2 4" type="ORF">Y20F4.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDO41106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293338.1">
        <property type="nucleotide sequence ID" value="NM_001306409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="X5LPW2"/>
    <dbReference type="GeneID" id="245999"/>
    <dbReference type="KEGG" id="cel:CELE_Y20F4.4"/>
    <dbReference type="AGR" id="WB:WBGene00021239"/>
    <dbReference type="CTD" id="245999"/>
    <dbReference type="WormBase" id="Y20F4.4b">
        <property type="protein sequence ID" value="CE49702"/>
        <property type="gene ID" value="WBGene00021239"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385980_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021239">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="X5LPW2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDO41106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y20F4.4b"/>
        </source>
    </evidence>
    <sequence length="120" mass="13947" checksum="A49235C341459717" modified="2014-06-11" version="1">MRKIKEKGRRLEQEKMGDSIAPNAAGTPPPTPPSVAAMLEPKEELDEDEPSTSTNVPVLRRVNSPPAQSTSYARRNDGKRHPSKSRSSRDDRDHRRDRDYDRRRGDDRRRDNHSHPYRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>X5LPW7</accession>
    <name>X5LPW7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">pcyt-2.1</name>
        <name evidence="13" type="ORF">CELE_Y37E3.11</name>
        <name evidence="15" type="ORF">Y37E3.11</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDO41111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293343.1">
        <property type="nucleotide sequence ID" value="NM_001306414.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="X5LPW7"/>
    <dbReference type="SMR" id="X5LPW7"/>
    <dbReference type="PeptideAtlas" id="X5LPW7"/>
    <dbReference type="GeneID" id="171770"/>
    <dbReference type="AGR" id="WB:WBGene00021352"/>
    <dbReference type="CTD" id="171770"/>
    <dbReference type="WormBase" id="Y37E3.11d">
        <property type="protein sequence ID" value="CE49716"/>
        <property type="gene ID" value="WBGene00021352"/>
        <property type="gene designation" value="pcyt-2.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031246_2_2_1"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021352">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="X5LPW7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="140"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDO41111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="Y37E3.11d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="X5LPW7"/>
        </source>
    </evidence>
    <sequence length="302" mass="34221" checksum="75F307291F65E8A3" modified="2014-06-11" version="1">MVAGIKWVDEVVENAPYATTVETLDKYDCDFCVHGDDITLTADGKDTYQEVKDHQRYRECKRTCGVSTTDLVGRMLLLTKNHHTQDEHIEQHVERARSLSTDNVAMSPWTRVSRFIPTTTTILEFAEGRPPKPTDKVVYVTGSFDLFHIGHLAFLEKAKEFGDYLIVGILSDQTVNQYKGSNHPIMSIHERVLSVLAYKPVNEVVFGAPYEITSDILDQFNVQAVINGFRDNNSSVVNSSLASIDPFAEAKRRGIYHEVDSGSDMTTDLIIDRIIHHRLEYETRNKKKEKKEADVAKAMNLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-30" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MCZ8-4</accession>
    <name>CNNM3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of Metal transporter cnnm-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">CNNM family homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cnnm-3</name>
        <name evidence="3" type="ORF">C33D12.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006276" last="E1006276">
            <title>Mg2+ extrusion from intestinal epithelia by CNNM proteins is essential for gonadogenesis via AMPK-TORC1 signaling in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ishii T."/>
                <person name="Funato Y."/>
                <person name="Hashizume O."/>
                <person name="Yamazaki D."/>
                <person name="Hirata Y."/>
                <person name="Nishiwaki K."/>
                <person name="Kono N."/>
                <person name="Arai H."/>
                <person name="Miki H."/>
            </authorList>
            <dbReference type="PubMed" id="27564576"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006276"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A131MCZ8-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_058664 VSP_058663"/>
        </isoform>
        <isoform>
            <id>A0A131MCZ8-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_058662 VSP_058664 VSP_058663"/>
        </isoform>
        <isoform>
            <id>A0A131MCZ8-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A131MCZ8-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_058662"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001368594.1">
        <property type="nucleotide sequence ID" value="NM_001380926.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C33D12.2d">
        <property type="protein sequence ID" value="CE51314"/>
        <property type="gene ID" value="WBGene00016343"/>
        <property type="gene designation" value="cnnm-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C33D12.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C33D12.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C33D12.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C33D12.2d"/>
        </source>
    </evidence>
    <sequence length="219" mass="24595" checksum="BA735514F6AAFC3F" modified="2016-05-11" version="1" precursor="true">MSQIVNTAHAKCAINIQMLAVTIQVMSTCHKIFSSNYILPTILEKLIRKNCKKVETTQFSCLKEVGVVQPKPAVLFTKGEFSNKFIMILSGRAVVTIGKEEMRLEAGAWHSFGTEVLDAMAEAIERSLNQSTSRSTVSLNTEITNNSIGFIPDFDTVILYECVFCEITAADLLLAYNSSQIMQNNTKMQVVRSNSRISLIEEIPKKYLIGRWKRRGTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1I6CM53</accession>
    <name>A0A1I6CM53_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Adenomatous polyposis coli protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">apr-1</name>
        <name evidence="16" type="ORF">CELE_K04G2.8</name>
        <name evidence="18" type="ORF">K04G2.8</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Interacts (via N-terminus) with bar-1 and hmp-2; the interaction with hmp-2 is relatively weak. Interacts (via C-terminus) with pry-1 (via N-terminus). Probably associates with bar-1, gsk-3, pry-1 in a complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenomatous polyposis coli (APC) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SFQ94271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001334202.1">
        <property type="nucleotide sequence ID" value="NM_001347280.1"/>
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    <dbReference type="SMR" id="A0A1I6CM53"/>
    <dbReference type="GeneID" id="172591"/>
    <dbReference type="AGR" id="WB:WBGene00000156"/>
    <dbReference type="CTD" id="172591"/>
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        <property type="protein sequence ID" value="CE51809"/>
        <property type="gene ID" value="WBGene00000156"/>
        <property type="gene designation" value="apr-1"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
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    <dbReference type="Bgee" id="WBGene00000156">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Adenomatous polyposis coli protein-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026818">
        <property type="entry name" value="Apc_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607">
        <property type="entry name" value="ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607:SF12">
        <property type="entry name" value="APC-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0879">Wnt signaling pathway</keyword>
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            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="726"/>
            <end position="751"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="778"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="800"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="876"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SFQ94271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="K04G2.8c"/>
        </source>
    </evidence>
    <sequence length="892" mass="99599" checksum="E0AC49C88CF2F1DA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1I6CM55</accession>
    <name>A0A1I6CM55_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hgap-2</name>
        <name evidence="3" type="ORF">CELE_D2085.5</name>
        <name evidence="5" type="ORF">D2085.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SFQ94273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001334204.1">
        <property type="nucleotide sequence ID" value="NM_001347287.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1I6CM55"/>
    <dbReference type="GeneID" id="3564922"/>
    <dbReference type="AGR" id="WB:WBGene00008430"/>
    <dbReference type="CTD" id="3564922"/>
    <dbReference type="WormBase" id="D2085.5l">
        <property type="protein sequence ID" value="CE51796"/>
        <property type="gene ID" value="WBGene00008430"/>
        <property type="gene designation" value="hgap-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009983at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008430">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1I6CM55">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
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        <property type="entry name" value="Rap/Ran-GAP_sf"/>
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    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
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        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="206"/>
            <end position="326"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1519"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="784"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SFQ94273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="D2085.5l"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1I6CM55"/>
        </source>
    </evidence>
    <sequence length="1742" mass="192196" checksum="F4B3D8C5877E34DC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1I6CM68</accession>
    <name>A0A1I6CM68_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1 3" type="ORF">C40H1.7</name>
        <name evidence="1" type="ORF">CELE_C40H1.7</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SFQ94281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001334210.1">
        <property type="nucleotide sequence ID" value="NM_001347285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1I6CM68"/>
    <dbReference type="SMR" id="A0A1I6CM68"/>
    <dbReference type="ESTHER" id="caeel-C40H1.7">
        <property type="family name" value="Lipase_3"/>
    </dbReference>
    <dbReference type="GeneID" id="176311"/>
    <dbReference type="KEGG" id="cel:CELE_C40H1.7"/>
    <dbReference type="AGR" id="WB:WBGene00008042"/>
    <dbReference type="CTD" id="176311"/>
    <dbReference type="WormBase" id="C40H1.7b">
        <property type="protein sequence ID" value="CE51810"/>
        <property type="gene ID" value="WBGene00008042"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008042">
        <property type="expression patterns" value="Expressed in material anatomical entity and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1I6CM68">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SFQ94281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C40H1.7b"/>
        </source>
    </evidence>
    <sequence length="48" mass="5435" checksum="4BA9A09F68D1C0DE" modified="2017-01-18" version="1">MDLYRWSADGCPKNKEDYRPIAESAVKNGKTFSYDLLIVILGAVIIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1E4W4</accession>
    <name>A0A3B1E4W4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">abts-3</name>
        <name evidence="11" type="ORF">CELE_F57F10.1</name>
        <name evidence="13" type="ORF">F57F10.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="VAY52101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355398.1">
        <property type="nucleotide sequence ID" value="NM_001368589.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1E4W4"/>
    <dbReference type="SMR" id="A0A3B1E4W4"/>
    <dbReference type="GeneID" id="174024"/>
    <dbReference type="KEGG" id="cel:CELE_F57F10.1"/>
    <dbReference type="AGR" id="WB:WBGene00019018"/>
    <dbReference type="CTD" id="174024"/>
    <dbReference type="WormBase" id="F57F10.1d">
        <property type="protein sequence ID" value="CE52683"/>
        <property type="gene ID" value="WBGene00019018"/>
        <property type="gene designation" value="abts-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019018">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1E4W4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000018">
        <property type="entry name" value="Sodium bicarbonate transporter protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000002">
        <property type="entry name" value="Solute carrier family 4 member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="638"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="843"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="10">
        <location>
            <begin position="336"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VAY52101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F57F10.1d"/>
        </source>
    </evidence>
    <sequence length="878" mass="99164" checksum="8D53854A4A1A58C7" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1E567</accession>
    <name>A0A3B1E567_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F55F3.4</name>
        <name evidence="2 4" type="ORF">F55F3.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1E567"/>
    <dbReference type="AGR" id="WB:WBGene00010118"/>
    <dbReference type="WormBase" id="F55F3.4b">
        <property type="protein sequence ID" value="CE52794"/>
        <property type="gene ID" value="WBGene00010118"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5807411at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010118">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1E567">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017266123" evidence="1">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VAY52624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F55F3.4b"/>
        </source>
    </evidence>
    <sequence length="334" mass="38003" checksum="B9063E8693A39811" modified="2018-12-05" version="1">MVFRKRILLFLLVPFVTTSKKWLEIGSQKSESVIFPSNDIYGLIGPGDNPVVCLNISFERPMEVSLGDCYTSIPIRSIQNKIIHINRSQVDHAFNQILEGHESCEPNQLEIHIANNENYTVTGWYEVYRCMRQRTQFPSSGKQDTVVLHNDEYLPVVSTWEDRLTSIRFRLSRGVGVRRRIDMFQAIHAAIVSFSKTICFEYHGVGFIKFSMSKCDVSTKITVVLNSDTVFGLSHKEKSILKKINFEKCTGNEEWFIDIEPISEHAVTGLLDIYSCSPDSGEAEDIGSYFPTWIPNTSIMGLTRTIYFALLPYSEGHYSADLKQLLDTAVCDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P6PCU5</accession>
    <name>A0A3P6PCU5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">grd-6</name>
        <name evidence="4" type="ORF">CELE_T18H9.1</name>
        <name evidence="6" type="ORF">T18H9.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="417"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="560"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG4685896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="C30D11.1r"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8D7ZEX1"/>
        </source>
    </evidence>
    <sequence length="788" mass="88216" checksum="338EB50C3005D80A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D7ZEX2</accession>
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        <submittedName>
            <fullName evidence="6">C2 domain-containing protein</fullName>
        </submittedName>
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        <name evidence="6 8" type="primary">mctp-1</name>
        <name evidence="6" type="ORF">CELE_D2092.1</name>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAG4685879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001382264.1">
        <property type="nucleotide sequence ID" value="NM_001395338.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A8D7ZEX2"/>
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    <dbReference type="AGR" id="WB:WBGene00017063"/>
    <dbReference type="CTD" id="172382"/>
    <dbReference type="WormBase" id="D2092.1c">
        <property type="protein sequence ID" value="CE54325"/>
        <property type="gene ID" value="WBGene00017063"/>
        <property type="gene designation" value="mctp-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG4685879.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="D2092.1c"/>
        </source>
    </evidence>
    <sequence length="770" mass="89436" checksum="60CDF48322A47B9D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D7ZEY3</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    <dbReference type="WormBase" id="C30D11.1p">
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        <property type="gene ID" value="WBGene00006830"/>
        <property type="gene designation" value="unc-103"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000001">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000107">
        <property type="entry name" value="Potassium voltage-gated channel unc-103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003967">
        <property type="entry name" value="K_chnl_volt-dep_ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF548">
        <property type="entry name" value="GH12235P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01470">
        <property type="entry name" value="ERGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="427"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="570"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="701"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG4685894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="C30D11.1p"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8D7ZEY3"/>
        </source>
    </evidence>
    <sequence length="798" mass="88762" checksum="2E8E7C9D5ADC1847" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I7Y6</accession>
    <name>A0A8D9I7Y6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">pat-9</name>
        <name evidence="11" type="ORF">CELE_T27B1.2</name>
        <name evidence="13" type="ORF">T27B1.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAG8860265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001382748.1">
        <property type="nucleotide sequence ID" value="NM_001395794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9I7Y6"/>
    <dbReference type="GeneID" id="181714"/>
    <dbReference type="AGR" id="WB:WBGene00003933"/>
    <dbReference type="CTD" id="181714"/>
    <dbReference type="WormBase" id="T27B1.2b">
        <property type="protein sequence ID" value="CE54366"/>
        <property type="gene ID" value="WBGene00003933"/>
        <property type="gene designation" value="pat-9"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001666">
        <property type="entry name" value="MDS1 and EVI1 complex locus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001729">
        <property type="entry name" value="Zinc finger protein 337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF106">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG8860265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="T27B1.2b"/>
        </source>
    </evidence>
    <sequence length="472" mass="52712" checksum="A9CA26F7F1A2DFB0" modified="2022-01-19" version="1">MENRTPMQHHSGYEIVKSEPPSTPKTLIKSSYMENTPEMVFGSFPIHSGFCTQVVTHTDPMNNNNQPKTNANGRALAADRKRPYPCNLCSSKFGSKMELEEHQNSHTGQKPFECDFQTCNARFNRRSTLWNHKRIHSDAKPFVCTVCQMTFKWKNSLKCHKDMHQRKNETSAHLDNDLRQLTYATAAKRKLQMEQEENGGLPASSSASSVISHPLITTTSGNKKRSKAAKAKQTPSSLATTLSQVHLGAVQPLHASALVPPSDHQIDLDTTSLDSLMQSQNQNFLMQLYGYSDDGRHNGGMLSLDDTMLSNLSDSKSDSGSSSGGLSIQLPMQTINMLNFRNLGTQQLPPVHQLASSLPSVSSGMDYVNVNQHDSHYIVSQPDMMLGNQPLYHNGSFANIEKSNPHNNQFTIDSCVLLPSSRQDYPFDYTMVNQQYPMQEQVHDQTVGVSVVQQHYAEQAHAHGKTVPHEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4SQK1</accession>
    <name>A0A8S4SQK1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-binding domain-containing protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diphthamide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein DPH6 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">dph-6</name>
        <name evidence="14" type="ORF">CELE_E01A2.5</name>
        <name evidence="16" type="ORF">E01A2.5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Diphthine--ammonia ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="3"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAH2652341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001407515.1">
        <property type="nucleotide sequence ID" value="NM_001420551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4SQK1"/>
    <dbReference type="SMR" id="A0A8S4SQK1"/>
    <dbReference type="GeneID" id="183978"/>
    <dbReference type="KEGG" id="cel:CELE_E01A2.5"/>
    <dbReference type="AGR" id="WB:WBGene00017087"/>
    <dbReference type="CTD" id="183978"/>
    <dbReference type="WormBase" id="E01A2.5b">
        <property type="protein sequence ID" value="CE54551"/>
        <property type="gene ID" value="WBGene00017087"/>
        <property type="gene designation" value="dph-6"/>
    </dbReference>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH2652341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="E01A2.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4SQK1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21222" checksum="185490CD7F67D26B" modified="2022-10-12" version="1">MQLPLYRREITGEPKNQKSDYEKTDGDEVEDLFELLCEVKKHHPEVKGVSAGAILSSYQKVRVEDICRRLDLVPLCFLWEREQNGLLAEMVENGLDAILIKVAAIGLGEQHLGKTLSEMAPIMKVLQDKYGVHPCGEGGEFESFVRDCPLFKKRIVIDETETVTHQDDPIAPVFYLRLKKMHLEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4SQL1</accession>
    <name>A0A8S4SQL1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T24B8.4</name>
        <name evidence="2 4" type="ORF">T24B8.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAH2659124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4SQL1"/>
    <dbReference type="AGR" id="WB:WBGene00011978"/>
    <dbReference type="WormBase" id="T24B8.4j">
        <property type="protein sequence ID" value="CE54526"/>
        <property type="gene ID" value="WBGene00011978"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877983at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH2659124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T24B8.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4SQL1"/>
        </source>
    </evidence>
    <sequence length="268" mass="28870" checksum="6F8FBC52CB1DFBCD" modified="2022-10-12" version="1">MSPISSSVSSASAPSPSSLSAGSVSPDSTPKKRIVGSNANFEKAKEKWGAAPKADDSPPTTRGYLMRESKTPTREETTPVREKTPVKTIEEPKSKKVTASSALNKNKEKEKSPPCFAVTAAEAKGAAAVAKSKSRKKSLKNTPSVPTSTITTTSTTTNKPTSTSTKQTTSSSSTEHSPSPMATSSQKRDSISNTDVKKKTPYGQPMSGTVADRANKFRQQLQADNEKGKKPWQISFDEFTVPHPSQMRDNIRFNIDLSHDLPLSISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4SQL6</accession>
    <name>A0A8S4SQL6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome activator PA28 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">psme-3</name>
        <name evidence="4" type="ORF">CELE_Y66D12A.9</name>
        <name evidence="6" type="ORF">Y66D12A.9</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA28 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAH2663879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001407530.1">
        <property type="nucleotide sequence ID" value="NM_001420556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4SQL6"/>
    <dbReference type="SMR" id="A0A8S4SQL6"/>
    <dbReference type="GeneID" id="176588"/>
    <dbReference type="KEGG" id="cel:CELE_Y66D12A.9"/>
    <dbReference type="AGR" id="WB:WBGene00013435"/>
    <dbReference type="CTD" id="176588"/>
    <dbReference type="WormBase" id="Y66D12A.9b">
        <property type="protein sequence ID" value="CE54531"/>
        <property type="gene ID" value="WBGene00013435"/>
        <property type="gene designation" value="psme-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6591885at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.180:FF:000001">
        <property type="entry name" value="Proteasome activator complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009077">
        <property type="entry name" value="Proteasome_activ_PA28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660:SF2">
        <property type="entry name" value="LD45860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660">
        <property type="entry name" value="PROTEASOME REGULATOR PA28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH2663879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y66D12A.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4SQL6"/>
        </source>
    </evidence>
    <sequence length="136" mass="16091" checksum="0FC933E041041B40" modified="2022-10-12" version="1">MDLVRPKLRDAVEQCNNVKMWITLLIPRIEDGNNFGVGIQEETLSEVRNVESEAASFLDQMSRYFTTRGKLITKIAKYPHVDDYRRAILDMDEKQFINIRLVVLEMRNHFSTLHDMIMKNYEKIKVPRTSNTEHLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-09-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C0HLB4</accession>
    <accession>P34546</accession>
    <accession>P83577</accession>
    <name>VATL3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase 16 kDa proteolipid subunit c 3</fullName>
            <shortName evidence="6">V-ATPase 16 kDa proteolipid subunit c 3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump 16 kDa proteolipid subunit c 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vha-2</name>
        <name evidence="7" type="ORF">R10E11.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="22570" last="22576">
            <title>Multiple genes for vacuolar-type ATPase proteolipids in Caenorhabditis elegans: a new gene, vha-3, has a distinct cell-specific distribution.</title>
            <authorList>
                <person name="Oka T."/>
                <person name="Yamamoto R."/>
                <person name="Futai M."/>
            </authorList>
            <dbReference type="PubMed" id="9712884"/>
            <dbReference type="DOI" id="10.1074/jbc.273.35.22570"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Involved in necrotic cell death. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-ATPase accumulation in proximal oocytes and induces lysosomal acidification which leads to engulfing of protein aggregates by lysosomes and subsequent clearance of the aggregates. Lysosomal acidification also leads to changes in mitochondrial morphology and function. Mitochondria in distal immature oocytes are fragmented, produce high levels of reactive oxygen species (ROS) and have high membrane potential, indicative of metabolic inactivity. In contrast, mitochondria in proximal mature oocytes are tubular with lower ROS levels and membrane potential, indicative of an active metabolic state required for aggregate mobilization before clearance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="tissue specificity">
        <text evidence="5">Expressed ubiquitously. Higher levels of vha-2 are found in adult H-shaped excretory cell and rectum. Higher levels of vha-3 are found in gastrointestinal and hypodermal cells, as well as H-shaped excretory cell.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="5">High levels during embryogenesis, moderate levels during L1, L4 and adult stages and very low levels during L2 and L3 stages.</text>
    </comment>
    <comment type="miscellaneous">
        <text>Vha-11 and vha-3 are transcribed on a dicistronic transcript where vha-3 is the upstream transcript and vha-11 the downstream.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AB009566">
        <property type="protein sequence ID" value="BAA75066.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAA82355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S40714">
        <property type="entry name" value="S40714"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_499166.1">
        <property type="nucleotide sequence ID" value="NM_066765.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C0HLB4"/>
    <dbReference type="SMR" id="C0HLB4"/>
    <dbReference type="FunCoup" id="C0HLB4">
        <property type="interactions" value="2184"/>
    </dbReference>
    <dbReference type="IntAct" id="C0HLB4">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="R10E11.2.1">
        <property type="protein sequence ID" value="R10E11.2.1"/>
        <property type="gene ID" value="WBGene00006911"/>
    </dbReference>
    <dbReference type="GeneID" id="187779"/>
    <dbReference type="KEGG" id="cel:CELE_R10E11.2"/>
    <dbReference type="KEGG" id="cel:CELE_Y38F2AL.4"/>
    <dbReference type="AGR" id="WB:WBGene00006911"/>
    <dbReference type="CTD" id="177018"/>
    <dbReference type="WormBase" id="R10E11.2">
        <property type="protein sequence ID" value="CE06290"/>
        <property type="gene ID" value="WBGene00006911"/>
        <property type="gene designation" value="vha-2"/>
    </dbReference>
    <dbReference type="InParanoid" id="C0HLB4"/>
    <dbReference type="OMA" id="MGVMKPD"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Reactome" id="R-CEL-1222556">
        <property type="pathway name" value="ROS and RNS production in phagocytes"/>
    </dbReference>
    <dbReference type="Reactome" id="R-CEL-6798695">
        <property type="pathway name" value="Neutrophil degranulation"/>
    </dbReference>
    <dbReference type="Reactome" id="R-CEL-77387">
        <property type="pathway name" value="Insulin receptor recycling"/>
    </dbReference>
    <dbReference type="Reactome" id="R-CEL-917977">
        <property type="pathway name" value="Transferrin endocytosis and recycling"/>
    </dbReference>
    <dbReference type="Reactome" id="R-CEL-9639288">
        <property type="pathway name" value="Amino acids regulate mTORC1"/>
    </dbReference>
    <dbReference type="Reactome" id="R-CEL-983712">
        <property type="pathway name" value="Ion channel transport"/>
    </dbReference>
    <dbReference type="PRO" id="PR:C0HLB4"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006911">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C0HLB4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1210">Necrosis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000445076" description="V-type proton ATPase 16 kDa proteolipid subunit c 3">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="4">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="4">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="4">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="4">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="site" description="Essential for proton translocation" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="C0HLB3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P23956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P63081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="9712884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="R10E11.2"/>
        </source>
    </evidence>
    <sequence length="161" mass="16410" checksum="67EDBD2124F12F6E" modified="2018-09-12" version="1">MSYDLETAERAAYAPFFGYMGAASAQIFTVLGAAYGTAKSAVGICSMGVMRPELIMKSVIPVIMAGIIGIYGLVVAMVLKGKVTSASAGYDLNKGFAHLAAGLTCGLCGLGAGYAIGIVGDAGVRGTAQQPRLFVGMILILIFSEVLGLYGMIVALILGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-05" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C0P272</accession>
    <name>C0P272_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_K11H3.8</name>
        <name evidence="2 4" type="ORF">K11H3.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAX51681.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C0P272"/>
    <dbReference type="STRING" id="6239.K11H3.8a.1"/>
    <dbReference type="PaxDb" id="6239-K11H3.8a"/>
    <dbReference type="AGR" id="WB:WBGene00185002"/>
    <dbReference type="WormBase" id="K11H3.8a">
        <property type="protein sequence ID" value="CE54106"/>
        <property type="gene ID" value="WBGene00185002"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5829632at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00185002">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C0P272">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAX51681.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K11H3.8a"/>
        </source>
    </evidence>
    <sequence length="246" mass="28541" checksum="22A9B92E8FA9CCAC" modified="2020-06-17" version="2">MPETGMEIMKIEMNMVITVIDKVQAQWILGTNLYRPNRPLEQQKEARKRCLSGNSGPEPGEINTDSQEMSDMVPYGPEPPPPKKRNDEYVLRSKGNIRSSDEKRLTVGKRSLPFYYGDEDKKKTSLKKIIALEFASILRTDYVKLEKRQRDQLHNICNQWELPDNCRFCKCALKFAPNFLSHVLSIPHITKSMDQYDRRFTFEGDYRMLKNEIEKVKTNCRDAPSPLPPAMDPVAPYHVRDKCTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-05" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>C0P274</accession>
    <name>C0P274_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">ced-7</name>
        <name evidence="12" type="ORF">C48B4.4</name>
        <name evidence="10" type="ORF">CELE_C48B4.4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAX51629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255012.1">
        <property type="nucleotide sequence ID" value="NM_001268083.3"/>
    </dbReference>
    <dbReference type="SMR" id="C0P274"/>
    <dbReference type="PeptideAtlas" id="C0P274"/>
    <dbReference type="GeneID" id="176352"/>
    <dbReference type="AGR" id="WB:WBGene00000421"/>
    <dbReference type="CTD" id="176352"/>
    <dbReference type="WormBase" id="C48B4.4d">
        <property type="protein sequence ID" value="CE20575"/>
        <property type="gene ID" value="WBGene00000421"/>
        <property type="gene designation" value="ced-7"/>
    </dbReference>
    <dbReference type="OMA" id="IITINTY"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="PhylomeDB" id="C0P274"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000421">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C0P274">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0000315"/>
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</entry>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2009-05-05" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAX51660.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F45H7.2c"/>
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    </evidence>
    <sequence length="228" mass="25950" checksum="05CFA5F25DE257FF" modified="2009-05-05" version="1">MDAEDDNPNLTELGLKGPRSFLVDRVIDLIRDHSDQWKNWTIEGSFRGIEISSKRPSDSHPLKTFRVWLNVPAGPKSVMMRLLKERYTWDSSVINWRHLEYVSAPDTDIHQYVVNETIGHPTKDCHVARFHSSGLTEIRGACAIAERSVKCTEDQLLGGVSATIFDQRFLIEPVSGGQSRVNYIARVDLKGRSLQWYNKSFGSIMCRHLDRLRESFHLGDKGGPETNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-05" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C0P283</accession>
    <name>C0P283_CAEEL</name>
    <protein>
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        <alternativeName>
            <fullName evidence="8">Uncoordinated protein 119</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">unc-119</name>
        <name evidence="10" type="ORF">CELE_M142.1</name>
        <name evidence="12" type="ORF">M142.1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAX51683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255090.1">
        <property type="nucleotide sequence ID" value="NM_001268161.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C0P283"/>
    <dbReference type="SMR" id="C0P283"/>
    <dbReference type="PeptideAtlas" id="C0P283"/>
    <dbReference type="GeneID" id="176519"/>
    <dbReference type="AGR" id="WB:WBGene00006843"/>
    <dbReference type="CTD" id="31664"/>
    <dbReference type="WormBase" id="M142.1b">
        <property type="protein sequence ID" value="CE43523"/>
        <property type="gene ID" value="WBGene00006843"/>
        <property type="gene designation" value="unc-119"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088825_1_1_1"/>
    <dbReference type="OrthoDB" id="10248777at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006843">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C0P283">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010171">
        <property type="term" value="P:body morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040024">
        <property type="term" value="P:dauer larval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007631">
        <property type="term" value="P:feeding behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030517">
        <property type="term" value="P:negative regulation of axon extension"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046662">
        <property type="term" value="P:regulation of egg-laying behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043051">
        <property type="term" value="P:regulation of nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.40:FF:000005">
        <property type="entry name" value="Protein unc-119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051519">
        <property type="entry name" value="PDE6D_unc-119_myristoyl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951:SF1">
        <property type="entry name" value="PROTEIN UNC-119 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951">
        <property type="entry name" value="RETINAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="9">
        <location>
            <begin position="45"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAX51683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="M142.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="C0P283"/>
        </source>
    </evidence>
    <sequence length="199" mass="23147" checksum="C5702CE74F770C35" modified="2009-05-05" version="1">MPRPPPVTEQAITTEAELLAKNQITPNDVLALPGITQGFLCSPSANVYNIEFTKFQIRDLDTEHVLFEIAKPENETEENLQAQAESARYVRYRFAPNFLKLKTVGATVEFKVGDVPITHFRMIERHFFKDRLLKCFDFEFGFCMPNSRNNCEHIYEFPQLSQQLMDDMINNPNETRSDSFYFVENKLVMHNKADYSYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-05" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>C0P284</accession>
    <name>C0P284_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_F11E6.8</name>
        <name evidence="6 8" type="ORF">F11E6.8</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAX51641.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255961.2">
        <property type="nucleotide sequence ID" value="NM_001269032.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C0P284"/>
    <dbReference type="SMR" id="C0P284"/>
    <dbReference type="GeneID" id="178530"/>
    <dbReference type="AGR" id="WB:WBGene00008711"/>
    <dbReference type="CTD" id="178530"/>
    <dbReference type="WormBase" id="F11E6.8b">
        <property type="protein sequence ID" value="CE50655"/>
        <property type="gene ID" value="WBGene00008711"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_7_40_1"/>
    <dbReference type="OMA" id="NAKVRHY"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008711">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C0P284">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000743">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000975">
        <property type="entry name" value="Protein CBG00445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="79"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAX51641.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F11E6.8b"/>
        </source>
    </evidence>
    <sequence length="385" mass="43173" checksum="5CE312DA27494805" modified="2015-11-11" version="2">MGEVFMNPVFLDTSDSDSEQSSSSRYRSPSHPSSLPRSSSRQQSSTSVSSTYSTQSLLQLIGSDLRQSLQGLLLPSEAVVLETIVGKGYFGNVYRGRMRDPAGRLIPVAVKTLKGERARDIAHIEKFLREGVVMKHLDHPHVLSLLGISISPAGNPWVVLPYMEGGDLKTYIADPNRALCVLELLDFAHQVAQGMSYLAAQHFVHRDLAARNCMISADRIVKVADFGLAVDLLDKESYIDESETGPARLPLKWLAPESLRDRRVFSSATDVWSFGVLMWELLTRAASPYGEVSNTKVRHYLETGMRLPQPTHCPDIIYDLMQCCWRSTPEDRPDFVFLSHRLRALLQENTPDPFTRRVRPGAEQFLLPVLPGRLFTNYFAAQMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-05" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>C0P286</accession>
    <name>C0P286_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">anoh-1</name>
        <name evidence="12" type="ORF">CELE_F56A8.1</name>
        <name evidence="14" type="ORF">F56A8.1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAX51675.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255191.1">
        <property type="nucleotide sequence ID" value="NM_001268262.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C0P286"/>
    <dbReference type="SMR" id="C0P286"/>
    <dbReference type="TCDB" id="1.A.17.1.9">
        <property type="family name" value="the calcium-dependent chloride channel (ca-clc) family"/>
    </dbReference>
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    <dbReference type="AGR" id="WB:WBGene00010138"/>
    <dbReference type="CTD" id="176739"/>
    <dbReference type="WormBase" id="F56A8.1a">
        <property type="protein sequence ID" value="CE44118"/>
        <property type="gene ID" value="WBGene00010138"/>
        <property type="gene designation" value="anoh-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010873_0_0_1"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010138">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C0P286">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
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            <end position="293"/>
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            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="633"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="679"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="728"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="255"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAX51675.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F56A8.1a"/>
        </source>
    </evidence>
    <sequence length="822" mass="94816" checksum="8B784E13BD6CEED8" modified="2009-09-22" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRI6</accession>
    <name>C6KRI6_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">FIP (Fungus-Induced Protein) Related</fullName>
        </submittedName>
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    <gene>
        <name evidence="1 3" type="ORF">C09G9.8</name>
        <name evidence="1" type="ORF">CELE_C09G9.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001268418.1"/>
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    <dbReference type="AlphaFoldDB" id="C6KRI6"/>
    <dbReference type="GeneID" id="3565974"/>
    <dbReference type="KEGG" id="cel:CELE_C09G9.8"/>
    <dbReference type="AGR" id="WB:WBGene00007497"/>
    <dbReference type="CTD" id="3565974"/>
    <dbReference type="WormBase" id="C09G9.8b">
        <property type="protein sequence ID" value="CE43935"/>
        <property type="gene ID" value="WBGene00007497"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3225100_0_0_1"/>
    <dbReference type="OrthoDB" id="5869021at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007497">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAZ65466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C09G9.8b"/>
        </source>
    </evidence>
    <sequence length="44" mass="4856" checksum="12EAEB114CE397A0" modified="2009-09-01" version="1">MNKIIVTFLFIIVIYFTCSEASLFGMKVKMLKSTPVGAANISVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRI7</accession>
    <name>C6KRI7_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Glycine-rich cell wall structural protein 1.8-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="3 5" type="primary">grsp-2</name>
        <name evidence="3" type="ORF">CELE_T28C6.1</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255333.1">
        <property type="nucleotide sequence ID" value="NM_001268404.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRI7"/>
    <dbReference type="PeptideAtlas" id="C6KRI7"/>
    <dbReference type="GeneID" id="177693"/>
    <dbReference type="AGR" id="WB:WBGene00012118"/>
    <dbReference type="CTD" id="177693"/>
    <dbReference type="WormBase" id="T28C6.1b">
        <property type="protein sequence ID" value="CE43858"/>
        <property type="gene ID" value="WBGene00012118"/>
        <property type="gene designation" value="grsp-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012118">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRI7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002967286" evidence="2">
        <location>
            <begin position="18"/>
            <end position="293"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAZ65527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T28C6.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="C6KRI7"/>
        </source>
    </evidence>
    <sequence length="293" mass="25740" checksum="FD874869E5DE6436" modified="2009-09-01" version="1">MRLTLLLLAVVLAYVAAQGDGLFGGSDAGSGIGSSGGWGGSDASAGASAGGTGGGRGGGRGGSGGGRGGGSGGGRGGSGGAGAGGSGSGSGGWGGQDGGSSAGGWGGSQGGSQGGSSGGWGGSSRSDSGSGQGGWGGQQGGNSNAGGWGGSQGGQNGGGGRGGSGGQGGWGGSQDGGSQGGWGGQNGGGQGGNQGGGGGRGGNQGGEQGGWGGQGGSQGGSQGGSQGGWGNQGGQQGGGRGGQQGPGGWGGGGRGGGWGGHGGVGWGGRGDGWGRGSRWGWGRPSWGGWGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRI8</accession>
    <name>C6KRI8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine-rich cell wall structural protein 1.8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">grsp-2</name>
        <name evidence="3" type="ORF">CELE_T28C6.1</name>
        <name evidence="5" type="ORF">T28C6.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255336.1">
        <property type="nucleotide sequence ID" value="NM_001268407.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6KRI8"/>
    <dbReference type="GeneID" id="177693"/>
    <dbReference type="AGR" id="WB:WBGene00012118"/>
    <dbReference type="CTD" id="177693"/>
    <dbReference type="WormBase" id="T28C6.1c">
        <property type="protein sequence ID" value="CE43903"/>
        <property type="gene ID" value="WBGene00012118"/>
        <property type="gene designation" value="grsp-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012118">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6KRI8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002965787" evidence="2">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAZ65528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T28C6.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="C6KRI8"/>
        </source>
    </evidence>
    <sequence length="262" mass="22393" checksum="66865671B9F8D9C1" modified="2009-09-01" version="1">MRLTLLLLAVVLAYVAAQGDGLFGGSDAGSGIGSSGGWGGSDASAGASAGGTGGGRGGGRGGSGGGRGGGSGGGRGGSGGAGAGGSGSGSGGWGGQDGGSSAGGWGGSQGGSQGGSSGGWGGSSRSDSGSGQGGWGGQQGGNSNAGGWGGSQGGQNGGGGRGGSGGQGGWGGSQDGGSQGGWGGQNGGGQGGNQGGGGGRGGNQGGEQGGWGGQGGSQGGSQGGSQGGWGNQGGQQGGGRGGQQGPGGWGGGGRGGGWGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C6KRI9</accession>
    <name>C6KRI9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="E1B6R1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31238" checksum="127899C0BD1AE643" modified="2010-11-02" version="1">MCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARGYSIEKGAYVMALHKAAKDKRDKQVDSDSDSSERQRKKKNKRKHREIVEHENIVLINTIIGELGSQAASVSGTDYQNSPNGVSVDPGQPQPHHWGFAIKRSKYAQLNQPVANGANTPPEPSEGTPQEEEEFEEDFEEIEEETETEPGKGQSVSSKRRARRNRMQKYMQVMQRGRFHEIQAIREEVALSHGSARD</sequence>
</entry>
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    <accession>E1B6R9</accession>
    <name>E1B6R9_CAEEL</name>
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        <submittedName>
            <fullName evidence="8">Transmembrane protein 115</fullName>
        </submittedName>
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    <gene>
        <name evidence="8" type="ORF">CELE_F11A10.6</name>
        <name evidence="8 10" type="ORF">F11A10.6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBW48358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255619.1">
        <property type="nucleotide sequence ID" value="NM_001268690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6R9"/>
    <dbReference type="PeptideAtlas" id="E1B6R9"/>
    <dbReference type="GeneID" id="178149"/>
    <dbReference type="AGR" id="WB:WBGene00008687"/>
    <dbReference type="CTD" id="178149"/>
    <dbReference type="WormBase" id="F11A10.6b">
        <property type="protein sequence ID" value="CE45350"/>
        <property type="gene ID" value="WBGene00008687"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_903821_0_0_1"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008687">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6R9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBW48358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F11A10.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="E1B6R9"/>
        </source>
    </evidence>
    <sequence length="215" mass="24247" checksum="69DF015CCDB55D46" modified="2010-11-02" version="1">MTPICASVMVLMKQFLPDTIVLATPLGRIKYAHLPFLAIFVSFILALTKFTYFVSFLQITIGVQVSWTYLRFYKPHETDEIYGDGSEHFTWASLFPSRTQLFFTLIGKVCFRTLARMGVCKRQVRHVDLHSLQSGSVGINLPALENSAKDSERRRQKALKELNDRLNKTRTAEVASYGNWDDGDDDEPTEVTVVAPPPVSNVHSSKPAMDKESMA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-10-14" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>G5ECJ6-2</accession>
    <name>CSK1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Tyrosine-protein kinase csk-1</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">C-terminal src kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">csk-1</name>
        <name evidence="5" type="ORF">Y48G1C.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2003" name="FEBS Lett." volume="534" first="133" last="138">
            <title>Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans.</title>
            <authorList>
                <person name="Hirose T."/>
                <person name="Koga M."/>
                <person name="Ohshima Y."/>
                <person name="Okada M."/>
            </authorList>
            <dbReference type="PubMed" id="12527374"/>
            <dbReference type="DOI" id="10.1016/S0014-5793(02)03819-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF LYS-310</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2009" name="Genes Cells" volume="14" first="381" last="393">
            <title>Non-receptor tyrosine kinase CSK-1 controls pharyngeal muscle organization in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Takata N."/>
                <person name="Itoh B."/>
                <person name="Misaki K."/>
                <person name="Hirose T."/>
                <person name="Yonemura S."/>
                <person name="Okada M."/>
            </authorList>
            <dbReference type="PubMed" id="19210548"/>
            <dbReference type="DOI" id="10.1111/j.1365-2443.2008.01275.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF LYS-310</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5ECJ6-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_057936"/>
        </isoform>
        <isoform>
            <id>G5ECJ6-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001293162.1">
        <property type="nucleotide sequence ID" value="NM_001306233.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y48G1C.2b">
        <property type="protein sequence ID" value="CE49183"/>
        <property type="gene ID" value="WBGene00000812"/>
        <property type="gene designation" value="csk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="12527374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="BAC76831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y48G1C.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y48G1C.2b"/>
        </source>
    </evidence>
    <sequence length="624" mass="69914" checksum="9980A7D158AA3251" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-10-16" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>G5EDB9-2</accession>
    <name>RPGF_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Rap guanine nucleotide exchange factor</fullName>
            <shortName>RA-GEF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>PDZ-domain-containing exchange factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pxf-1</name>
        <name type="synonym">ra-gef</name>
        <name type="ORF">T14G10.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1999" name="J. Biol. Chem." volume="274" first="37815" last="37820">
            <title>RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans.</title>
            <authorList>
                <person name="Liao Y."/>
                <person name="Kariya K."/>
                <person name="Hu C.-D."/>
                <person name="Shibatohge M."/>
                <person name="Goshima M."/>
                <person name="Okada T."/>
                <person name="Watari Y."/>
                <person name="Gao X."/>
                <person name="Jin T.-G."/>
                <person name="Yamawaki-Kataoka Y."/>
                <person name="Kataoka T."/>
            </authorList>
            <dbReference type="PubMed" id="10608844"/>
            <dbReference type="DOI" id="10.1074/jbc.274.53.37815"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>POSSIBLE FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Mol. Biol. Cell" volume="16" first="106" last="116">
            <title>Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.</title>
            <authorList>
                <person name="Berkel W.P."/>
                <person name="Verheijen M.H."/>
                <person name="Cuppen E."/>
                <person name="Asahina M."/>
                <person name="de Rooij J."/>
                <person name="Jansen G."/>
                <person name="Plasterk R.H."/>
                <person name="Bos J.L."/>
                <person name="Zwartkruis F.J."/>
            </authorList>
            <dbReference type="PubMed" id="15525675"/>
            <dbReference type="DOI" id="10.1091/mbc.E04-06-0492"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND D)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EDB9-2</id>
            <name>b</name>
            <name>PXF-1-B</name>
            <sequence type="described" ref="VSP_053270 VSP_053269"/>
        </isoform>
        <isoform>
            <id>G5EDB9-3</id>
            <name>d</name>
            <name>PXF-1-C</name>
            <sequence type="described" ref="VSP_053271"/>
        </isoform>
        <isoform>
            <id>G5EDB9-1</id>
            <name>a</name>
            <name>PXF-1-A</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001023390.1">
        <property type="nucleotide sequence ID" value="NM_001028219.3"/>
    </dbReference>
    <dbReference type="WormBase" id="T14G10.2b">
        <property type="protein sequence ID" value="CE28081"/>
        <property type="gene ID" value="WBGene00004254"/>
        <property type="gene designation" value="pxf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="1311" mass="147004" checksum="A4870F07DC201F97" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-10-16" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>G5EDB9-3</accession>
    <name>RPGF_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform d of Rap guanine nucleotide exchange factor</fullName>
            <shortName>RA-GEF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>PDZ-domain-containing exchange factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pxf-1</name>
        <name type="synonym">ra-gef</name>
        <name type="ORF">T14G10.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1999" name="J. Biol. Chem." volume="274" first="37815" last="37820">
            <title>RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans.</title>
            <authorList>
                <person name="Liao Y."/>
                <person name="Kariya K."/>
                <person name="Hu C.-D."/>
                <person name="Shibatohge M."/>
                <person name="Goshima M."/>
                <person name="Okada T."/>
                <person name="Watari Y."/>
                <person name="Gao X."/>
                <person name="Jin T.-G."/>
                <person name="Yamawaki-Kataoka Y."/>
                <person name="Kataoka T."/>
            </authorList>
            <dbReference type="PubMed" id="10608844"/>
            <dbReference type="DOI" id="10.1074/jbc.274.53.37815"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>POSSIBLE FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Mol. Biol. Cell" volume="16" first="106" last="116">
            <title>Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.</title>
            <authorList>
                <person name="Berkel W.P."/>
                <person name="Verheijen M.H."/>
                <person name="Cuppen E."/>
                <person name="Asahina M."/>
                <person name="de Rooij J."/>
                <person name="Jansen G."/>
                <person name="Plasterk R.H."/>
                <person name="Bos J.L."/>
                <person name="Zwartkruis F.J."/>
            </authorList>
            <dbReference type="PubMed" id="15525675"/>
            <dbReference type="DOI" id="10.1091/mbc.E04-06-0492"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND D)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EDB9-2</id>
            <name>b</name>
            <name>PXF-1-B</name>
            <sequence type="described" ref="VSP_053269 VSP_053270"/>
        </isoform>
        <isoform>
            <id>G5EDB9-1</id>
            <name>a</name>
            <name>PXF-1-A</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EDB9-3</id>
            <name>d</name>
            <name>PXF-1-C</name>
            <sequence type="described" ref="VSP_053271"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255465.1">
        <property type="nucleotide sequence ID" value="NM_001268536.3"/>
    </dbReference>
    <dbReference type="WormBase" id="T14G10.2d">
        <property type="protein sequence ID" value="CE46125"/>
        <property type="gene ID" value="WBGene00004254"/>
        <property type="gene designation" value="pxf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="1347" mass="149268" checksum="19708909E535BC0E" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYF1</accession>
    <name>H2KYF1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Downstream Neighbor of SoN homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">dnsn-1</name>
        <name evidence="8" type="ORF">C24H12.5</name>
        <name evidence="6" type="ORF">CELE_C24H12.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DONSON family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD62830.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_493727.2">
        <property type="nucleotide sequence ID" value="NM_061326.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYF1"/>
    <dbReference type="SMR" id="H2KYF1"/>
    <dbReference type="GeneID" id="173431"/>
    <dbReference type="AGR" id="WB:WBGene00016074"/>
    <dbReference type="CTD" id="173431"/>
    <dbReference type="WormBase" id="C24H12.5a">
        <property type="protein sequence ID" value="CE50975"/>
        <property type="gene ID" value="WBGene00016074"/>
        <property type="gene designation" value="dnsn-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_530225_0_0_1"/>
    <dbReference type="OrthoDB" id="534063at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016074">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYF1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024861">
        <property type="entry name" value="Donson"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972">
        <property type="entry name" value="DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972:SF0">
        <property type="entry name" value="PROTEIN DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD62830.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="C24H12.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYF1"/>
        </source>
    </evidence>
    <sequence length="433" mass="48115" checksum="40F02145F8FE842D" modified="2015-11-11" version="2">MRIVSKVSFPWMNTRKSTGNVIVKFQTNDRFDGMQYFNKTFLNGYEDPTVPLPVSPMSILEAASLFYQFPVIPGLKMYPRITAEQENVSRVSLAPLVTSTMLEQWQECYAELYSSYKKGQRGSFYVATAVCNVLFTKMPLSGGGDDVAADDTSQSCSQAFRGQKLVAVITHTTSAIREHLRSQGVDFEAPKPTSSLKRVSSSPQLHHDQSTLDCLLASESKENSQMGPTTFGGIENSENSDESPLKKDQDSDENESPMKLANQWLNEIGVSPRTVKNTVSRELSSQVTDRAGFQCLVVHGSKIHALFNALMDSDVVHEKTGPYTKIPPTLIATSPFLYGQLLSLTKSSNIFAKAGTKCTEYELKLENGPVLPHCAKMMTQFIRSTNMCSTEEKPVTMQVMDRHTSQGMSDWTETATNWNTVTIAENCVKWTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYF3</accession>
    <name>H2KYF3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">vpat-1</name>
        <name evidence="7" type="ORF">CELE_F55A4.8</name>
        <name evidence="9" type="ORF">F55A4.8</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD62875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741718.2">
        <property type="nucleotide sequence ID" value="NM_171626.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYF3"/>
    <dbReference type="SMR" id="H2KYF3"/>
    <dbReference type="GeneID" id="180457"/>
    <dbReference type="AGR" id="WB:WBGene00018860"/>
    <dbReference type="CTD" id="180457"/>
    <dbReference type="WormBase" id="F55A4.8c">
        <property type="protein sequence ID" value="CE41818"/>
        <property type="gene ID" value="WBGene00018860"/>
        <property type="gene designation" value="vpat-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2529518_0_0_1"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018860">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYF3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD62875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F55A4.8c"/>
        </source>
    </evidence>
    <sequence length="84" mass="9544" checksum="077BEF711AEA2B56" modified="2012-03-21" version="1">MWQHFTCKSKFCRDKGFDDNFHTYGCVSGIFQAAFGFGSFIGPTFGSVVVERVGFRWTTTMIAFLHIILSTVVLLGIIIKKCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYF4</accession>
    <name>H2KYF4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SRR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_M02E1.1</name>
        <name evidence="2 4" type="ORF">M02E1.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD62918.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508088.3">
        <property type="nucleotide sequence ID" value="NM_075687.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYF4"/>
    <dbReference type="GeneID" id="180389"/>
    <dbReference type="AGR" id="WB:WBGene00019733"/>
    <dbReference type="CTD" id="180389"/>
    <dbReference type="WormBase" id="M02E1.1b">
        <property type="protein sequence ID" value="CE51105"/>
        <property type="gene ID" value="WBGene00019733"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400230_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019733">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYF4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD62918.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="M02E1.1b"/>
        </source>
    </evidence>
    <sequence length="677" mass="77804" checksum="F110FDC0B480600E" modified="2015-12-09" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYF7</accession>
    <name>H2KYF7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CLaudin-like in Caenorhabditis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">clc-3</name>
        <name evidence="6" type="ORF">CELE_ZK563.4</name>
        <name evidence="8" type="ORF">ZK563.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024994.1">
        <property type="nucleotide sequence ID" value="NM_001029823.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYF7"/>
    <dbReference type="GeneID" id="180625"/>
    <dbReference type="AGR" id="WB:WBGene00000524"/>
    <dbReference type="CTD" id="180625"/>
    <dbReference type="WormBase" id="ZK563.4b">
        <property type="protein sequence ID" value="CE33749"/>
        <property type="gene ID" value="WBGene00000524"/>
        <property type="gene designation" value="clc-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5831864at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000524">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYF7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD63044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="ZK563.4b"/>
        </source>
    </evidence>
    <sequence length="205" mass="23626" checksum="08DB2EF6B7E3EEA9" modified="2012-03-21" version="1">MAMQFTGLQVVSWILLLVGTGMLVIALISDYWSIHQPRNQMDNLQMHRGVLRQCITTRQYGSCNFRLSSMFKQLRNFMDGYDMYSERSMYRHLPTQTYEVFVALFLAISCMIASTVLLFGPFCCQRCKPSTTLLIFITGVFSGSGCLIYWNANREGKTFTLQQLQFQDVYHYDYGSDMNILSWSFWMAVVSTGILLCSAFLLCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYF9</accession>
    <name>H2KYF9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_R13H7.2</name>
        <name evidence="8 10" type="ORF">R13H7.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD63079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741432.3">
        <property type="nucleotide sequence ID" value="NM_171369.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYF9"/>
    <dbReference type="SMR" id="H2KYF9"/>
    <dbReference type="GeneID" id="177450"/>
    <dbReference type="AGR" id="WB:WBGene00020069"/>
    <dbReference type="CTD" id="177450"/>
    <dbReference type="WormBase" id="R13H7.2b">
        <property type="protein sequence ID" value="CE39028"/>
        <property type="gene ID" value="WBGene00020069"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020069">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYF9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895">
        <property type="entry name" value="PROTEIN CBG20548-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD63079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="R13H7.2b"/>
        </source>
    </evidence>
    <sequence length="408" mass="47648" checksum="283303500786E3B8" modified="2012-03-21" version="1">MLELIRMQSEEYLNADVSKWVEKFRREHGGDDSALLTLVPPGLYVTLNKYVFPFQFCFGVIGNVLNLCVLLSRNMRNEANILLSAMAICDIILLVTMLPNSLGVWYPMYMSDWFRKFIFNSNTWTIFLANFCSCITSWLILAVSVERYMGIRSPIHFRYHWRTARVFYLIFSIILGSFLLTFFHTFEYKYGYAMIRNGTKLYGSPVNVDKLVDVPTWVKTMIKTFKILQVVVGVVLPTIGIFIFNMLIVLMLRKSEYFNFRSAETKDENSNRKYSDLEIRQKRDIKVTFTVLAIICCYFVTHIPSVIPFVIELFNYHPDWVKVYAIPISGSWLITGKVANFVLFCMSSVYFRRRLRDLIRGRFDMCGAKKKFSGVSSAQSIKSQAYRLTRFRDRDDIQRQSSCLTQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYG1</accession>
    <name>H2KYG1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolethalus syndrome protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">hyls-1</name>
        <name evidence="3" type="ORF">C05C8.9</name>
        <name evidence="1" type="ORF">CELE_C05C8.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD63095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367430.1">
        <property type="nucleotide sequence ID" value="NM_001380690.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYG1"/>
    <dbReference type="SMR" id="H2KYG1"/>
    <dbReference type="GeneID" id="179118"/>
    <dbReference type="AGR" id="WB:WBGene00015466"/>
    <dbReference type="CTD" id="179118"/>
    <dbReference type="WormBase" id="C05C8.9b">
        <property type="protein sequence ID" value="CE29481"/>
        <property type="gene ID" value="WBGene00015466"/>
        <property type="gene designation" value="hyls-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1636953_0_0_1"/>
    <dbReference type="OrthoDB" id="6343432at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015466">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYG1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060756">
        <property type="term" value="P:foraging behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD63095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C05C8.9b"/>
        </source>
    </evidence>
    <sequence length="162" mass="19025" checksum="A74A039E266E6AAD" modified="2012-03-21" version="1">MANFTTENELEDILHQMGHHIHDKNQFATFKNEIDNLLDRELCLSDADEDVMNESLFASLSVDPAAQFIRQERNFPTENLNIQSPIVSRKRQGKRFIYENVELQSDFDDESSNEYPERNLLVDRAWRSIHRAMETCNGATEVLTFSFFFLLKNADFHSRFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYG2</accession>
    <name>H2KYG2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransf_11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C13A2.7</name>
        <name evidence="2" type="ORF">CELE_C13A2.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD63109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359829.1">
        <property type="nucleotide sequence ID" value="NM_001373052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYG2"/>
    <dbReference type="SMR" id="H2KYG2"/>
    <dbReference type="GeneID" id="182555"/>
    <dbReference type="AGR" id="WB:WBGene00015724"/>
    <dbReference type="CTD" id="182555"/>
    <dbReference type="WormBase" id="C13A2.7a">
        <property type="protein sequence ID" value="CE35233"/>
        <property type="gene ID" value="WBGene00015724"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2086982_0_0_1"/>
    <dbReference type="OrthoDB" id="428346at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYG2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C13A2.7a"/>
        </source>
    </evidence>
    <sequence length="117" mass="13375" checksum="437900DD5570F4B3" modified="2012-03-21" version="1">MHLRSFRIFSNKLWNILIYCATIVFIFIVIAKIIKASTFLLTDGYTTEEIPVEEETTTEASYDLSTYNTKTRKGLVTLEELNEKVLAGTGKVAETHERKNKSCFDNYKAKLACNQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYG4</accession>
    <name>H2KYG4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aromatic-L-amino-acid decarboxylase</fullName>
            <ecNumber evidence="8">4.1.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DOPA decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">bas-1</name>
        <name evidence="15" type="ORF">C05D2.4</name>
        <name evidence="13" type="ORF">CELE_C05D2.4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.28" evidence="8"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021150.1">
        <property type="nucleotide sequence ID" value="NM_001025979.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYG4"/>
    <dbReference type="SMR" id="H2KYG4"/>
    <dbReference type="PeptideAtlas" id="H2KYG4"/>
    <dbReference type="GeneID" id="175778"/>
    <dbReference type="KEGG" id="cel:CELE_C05D2.4"/>
    <dbReference type="AGR" id="WB:WBGene00000239"/>
    <dbReference type="CTD" id="175778"/>
    <dbReference type="WormBase" id="C05D2.4a">
        <property type="protein sequence ID" value="CE01141"/>
        <property type="gene ID" value="WBGene00000239"/>
        <property type="gene designation" value="bas-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_3_0_1"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000239">
        <property type="expression patterns" value="Expressed in material anatomical entity and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYG4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042416">
        <property type="term" value="P:dopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031987">
        <property type="term" value="P:locomotion involved in locomotory behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042427">
        <property type="term" value="P:serotonin biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034607">
        <property type="term" value="P:turning behavior involved in mating"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000186">
        <property type="entry name" value="Biogenic Amine Synthesis related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF167">
        <property type="entry name" value="AROMATIC-L-AMINO-ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0127">Catecholamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6 11 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD63122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="C05D2.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYG4"/>
        </source>
    </evidence>
    <sequence length="514" mass="58301" checksum="222EC5F65CCC5EAD" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYG5</accession>
    <name>H2KYG5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">madf-11</name>
        <name evidence="5" type="ORF">C05D2.6</name>
        <name evidence="3" type="ORF">CELE_C05D2.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001033348.1">
        <property type="nucleotide sequence ID" value="NM_001038259.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYG5"/>
    <dbReference type="PeptideAtlas" id="H2KYG5"/>
    <dbReference type="GeneID" id="175775"/>
    <dbReference type="AGR" id="WB:WBGene00015468"/>
    <dbReference type="CTD" id="175775"/>
    <dbReference type="WormBase" id="C05D2.6b">
        <property type="protein sequence ID" value="CE38996"/>
        <property type="gene ID" value="WBGene00015468"/>
        <property type="gene designation" value="madf-11"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6515516at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015468">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYG5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF66">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="55"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD63126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C05D2.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYG5"/>
        </source>
    </evidence>
    <sequence length="515" mass="58217" checksum="CA42B95470B56D78" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYH0</accession>
    <name>H2KYH0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srh-2</name>
        <name evidence="4" type="ORF">C05E4.14</name>
        <name evidence="2" type="ORF">CELE_C05E4.14</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD63245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379628.1">
        <property type="nucleotide sequence ID" value="NM_001392470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYH0"/>
    <dbReference type="SMR" id="H2KYH0"/>
    <dbReference type="GeneID" id="178584"/>
    <dbReference type="AGR" id="WB:WBGene00005228"/>
    <dbReference type="CTD" id="178584"/>
    <dbReference type="WormBase" id="C05E4.14b">
        <property type="protein sequence ID" value="CE45179"/>
        <property type="gene ID" value="WBGene00005228"/>
        <property type="gene designation" value="srh-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047463_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005228">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYH0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019422">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srh"/>
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        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS H"/>
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        <property type="entry name" value="7TM_GPCR_Srh"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C05E4.14b"/>
        </source>
    </evidence>
    <sequence length="257" mass="29386" checksum="2877B487C9A63D0B" modified="2012-03-21" version="1">MEIHTGATWKISTSFPFPLCSNGFLGEYGPECFLILVVILIYNGLACIFIFLYRMEVASKHTAPTMLYKITHFQTYLLYFLLVMLSGITVFMYPVLKEQLDYKQRLEMKVGPIPTFMLCDSCVFMIYDSPIFLIWFLVAYICIALAYIILFSSGIVTYKALKVSRASAAVRKIQKNIFMSLVVSTITHLGLLFIPLATFFMLSLLVPEWSKSSIVKYTSDFMVIMIQQHGAVSAVTMFLTNNLLRRTAKQLFYTEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Prion-like-(Q/N-rich)-domain-bearing protein</fullName>
        </submittedName>
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        <name evidence="2 4" type="primary">pqn-65</name>
        <name evidence="2" type="ORF">CELE_T13H2.4</name>
        <name evidence="4" type="ORF">T13H2.4</name>
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    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="PaxDb" id="6239-T13H2.4a"/>
    <dbReference type="PeptideAtlas" id="H2KYH2"/>
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    <dbReference type="KEGG" id="cel:CELE_T13H2.4"/>
    <dbReference type="AGR" id="WB:WBGene00004148"/>
    <dbReference type="CTD" id="180734"/>
    <dbReference type="WormBase" id="T13H2.4a">
        <property type="protein sequence ID" value="CE53672"/>
        <property type="gene ID" value="WBGene00004148"/>
        <property type="gene designation" value="pqn-65"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QR8W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240839_0_0_1"/>
    <dbReference type="OrthoDB" id="10685133at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004148">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYH2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0640">Prion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="858"/>
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        </location>
    </feature>
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        <location>
            <begin position="974"/>
            <end position="1013"/>
        </location>
    </feature>
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        <location>
            <begin position="1029"/>
            <end position="1131"/>
        </location>
    </feature>
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        <location>
            <begin position="1343"/>
            <end position="1435"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
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        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
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        </location>
    </feature>
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            <begin position="222"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
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        <location>
            <begin position="657"/>
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        </location>
    </feature>
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        <location>
            <begin position="791"/>
            <end position="806"/>
        </location>
    </feature>
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        <location>
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    </feature>
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            <begin position="1100"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1380"/>
            <end position="1418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63267.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T13H2.4a"/>
        </source>
    </evidence>
    <sequence length="1583" mass="176681" checksum="85B1A66447C144E8" modified="2019-11-13" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYH5</accession>
    <name>H2KYH5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TOM1-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tmyb-1</name>
        <name evidence="9" type="ORF">C07A12.7</name>
        <name evidence="7" type="ORF">CELE_C07A12.7</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508776.1">
        <property type="nucleotide sequence ID" value="NM_076375.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYH5"/>
    <dbReference type="SMR" id="H2KYH5"/>
    <dbReference type="PeptideAtlas" id="H2KYH5"/>
    <dbReference type="GeneID" id="180723"/>
    <dbReference type="KEGG" id="cel:CELE_C07A12.7"/>
    <dbReference type="AGR" id="WB:WBGene00015561"/>
    <dbReference type="CTD" id="180723"/>
    <dbReference type="WormBase" id="C07A12.7b">
        <property type="protein sequence ID" value="CE27055"/>
        <property type="gene ID" value="WBGene00015561"/>
        <property type="gene designation" value="tmyb-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043812_3_1_1"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015561">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYH5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14233">
        <property type="entry name" value="GAT_TOM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03565">
        <property type="entry name" value="VHS_Tom1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014645">
        <property type="entry name" value="TOM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF137">
        <property type="entry name" value="GH05942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036948">
        <property type="entry name" value="TOM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="5">
        <location>
            <begin position="47"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="6">
        <location>
            <begin position="215"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD63281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C07A12.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYH5"/>
        </source>
    </evidence>
    <sequence length="403" mass="44617" checksum="AC492C6E7218E1E6" modified="2012-03-21" version="1">MSNVSEQVSKAAESARETVAKVGESVSDFFQGNPFATPVGRKIELATDANLLATENWGLNMEICDFINGTEDGPRDAVRALKKRLHNAMSKNNAVVMYTLTVLETAVKNCNHHFHVLVCNKDFVQDLIKLIGPKFDAPQIIQERVLSLIQAWADAFRGDPTLAGVVQSYDDLKSKGVEFPAADLDTLAPIKTPKRTYDVLTIREQGQEPISATPAQLTKLRADLDVVNQNIKVFRETLTDVVPRKETADELQLLSDLNDTCRHMQQRVLDLIRYVSNDEVTYELLMVNDSLNSVFEKYDRFVSNRDGEKQAAEARDLIDMGDGKSLGDQLSALKVTAASGEPSSSASTSQDAYKANAEPQTDVGLAAAVSNKLPTEHEAAEMEKWLENQSEKKTKEQEENDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYH9</accession>
    <name>H2KYH9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rcs-1</name>
        <name evidence="8" type="ORF">C28G1.5</name>
        <name evidence="6" type="ORF">CELE_C28G1.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001361935.1">
        <property type="nucleotide sequence ID" value="NM_001375093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYH9"/>
    <dbReference type="SMR" id="H2KYH9"/>
    <dbReference type="PeptideAtlas" id="H2KYH9"/>
    <dbReference type="GeneID" id="259719"/>
    <dbReference type="AGR" id="WB:WBGene00016190"/>
    <dbReference type="CTD" id="259719"/>
    <dbReference type="WormBase" id="C28G1.5a">
        <property type="protein sequence ID" value="CE37204"/>
        <property type="gene ID" value="WBGene00016190"/>
        <property type="gene designation" value="rcs-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2294209_0_0_1"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016190">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYH9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16516">
        <property type="entry name" value="RING-HC_malin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052667">
        <property type="entry name" value="E3_ubiquitin-ligase_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47156:SF10">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47156">
        <property type="entry name" value="PROTEIN CBG20824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD63332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="C28G1.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYH9"/>
        </source>
    </evidence>
    <sequence length="101" mass="11304" checksum="DF9B01DA93278938" modified="2012-03-21" version="1">MSFPKCKICFDRFSDTDSEHIPRNLTCGHALCHKCITAMVNNSTVECPFCRTVTNIVNNDITKLLKNFALIEVIEDARYSLNKKDVVVSCITEGLLNSSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYI1</accession>
    <name>H2KYI1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">prk-1</name>
        <name evidence="17" type="ORF">C06E8.3</name>
        <name evidence="15" type="ORF">CELE_C06E8.3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001364690.1">
        <property type="nucleotide sequence ID" value="NM_001377564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYI1"/>
    <dbReference type="SMR" id="H2KYI1"/>
    <dbReference type="IntAct" id="H2KYI1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="175980"/>
    <dbReference type="AGR" id="WB:WBGene00004182"/>
    <dbReference type="CTD" id="175980"/>
    <dbReference type="WormBase" id="C06E8.3a">
        <property type="protein sequence ID" value="CE29027"/>
        <property type="gene ID" value="WBGene00004182"/>
        <property type="gene designation" value="prk-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479987_0_0_1"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="PhylomeDB" id="H2KYI1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004182">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYI1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14005">
        <property type="entry name" value="STKc_PIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000708">
        <property type="entry name" value="serine/threonine-protein kinase par-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000547">
        <property type="entry name" value="Serine/threonine-protein kinase prk-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051138">
        <property type="entry name" value="PIM_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984:SF25">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="34"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD63391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C06E8.3a"/>
        </source>
    </evidence>
    <sequence length="566" mass="63562" checksum="71B7E5E7F4C526C1" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYI2</accession>
    <name>H2KYI2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">prk-1</name>
        <name evidence="17" type="ORF">C06E8.3</name>
        <name evidence="15" type="ORF">CELE_C06E8.3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CE29028"/>
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        <property type="gene designation" value="prk-1"/>
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    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="34"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
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        <ligand>
            <name>ATP</name>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD63392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C06E8.3b"/>
        </source>
    </evidence>
    <sequence length="211" mass="24207" checksum="9626AB89E27E7C37" modified="2012-03-21" version="1">MIKRKLQDLAVCCSYQVDFLHEKKHSVKEFKRKYEVLDEIGRGGFGIVYEATTRQDGQQPVAVKFVQHKHVRSWTMTCRQLIPSEVCHLETCEDIPGVIKILDWFANSKGFLIVMERPANCMDLFDMVSVHGPLNEDMGKFIFKQVITTVFNMYSKHGLLHRDIKDENLIVNMNTGEVKLVDFGATAYAEKATKKEFQGLHSVILPSRMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYI3</accession>
    <name>H2KYI3_CAEEL</name>
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        <submittedName>
            <fullName evidence="5">WAPL domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="5 7" type="primary">cyk-1</name>
        <name evidence="5" type="ORF">CELE_F11H8.4</name>
        <name evidence="7" type="ORF">F11H8.4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
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    <dbReference type="AGR" id="WB:WBGene00000872"/>
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        <property type="protein sequence ID" value="CE47965"/>
        <property type="gene ID" value="WBGene00000872"/>
        <property type="gene designation" value="cyk-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_259864_0_0_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:small GTPase binding"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="196"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="806"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1197"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1197"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1397"/>
            <end position="1427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD63398.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F11H8.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYI3"/>
        </source>
    </evidence>
    <sequence length="1435" mass="159729" checksum="148759A045894146" modified="2013-02-06" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYI4</accession>
    <name>H2KYI4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipid-binding serum glycoprotein C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C06G1.1</name>
        <name evidence="3" type="ORF">CELE_C06G1.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_510689.1">
        <property type="nucleotide sequence ID" value="NM_078288.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYI4"/>
    <dbReference type="SMR" id="H2KYI4"/>
    <dbReference type="GeneID" id="181720"/>
    <dbReference type="AGR" id="WB:WBGene00015545"/>
    <dbReference type="CTD" id="181720"/>
    <dbReference type="WormBase" id="C06G1.1a">
        <property type="protein sequence ID" value="CE27054"/>
        <property type="gene ID" value="WBGene00015545"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_525014_0_0_1"/>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015545">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYI4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF133">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564296" evidence="1">
        <location>
            <begin position="18"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="2">
        <location>
            <begin position="282"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD63409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C06G1.1a"/>
        </source>
    </evidence>
    <sequence length="519" mass="57929" checksum="F874BA02D80604AB" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYI6</accession>
    <name>H2KYI6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">srx-50</name>
        <name evidence="7" type="ORF">CELE_Y43B11AL.2</name>
        <name evidence="9" type="ORF">Y43B11AL.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD63424.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367448.1">
        <property type="nucleotide sequence ID" value="NM_001380303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYI6"/>
    <dbReference type="SMR" id="H2KYI6"/>
    <dbReference type="GeneID" id="177478"/>
    <dbReference type="AGR" id="WB:WBGene00005941"/>
    <dbReference type="CTD" id="177478"/>
    <dbReference type="WormBase" id="Y43B11AL.2a">
        <property type="protein sequence ID" value="CE49365"/>
        <property type="gene ID" value="WBGene00005941"/>
        <property type="gene designation" value="srx-50"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059630_2_0_1"/>
    <dbReference type="OrthoDB" id="5825164at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYI6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017:SF44">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD63424.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y43B11AL.2a"/>
        </source>
    </evidence>
    <sequence length="293" mass="33584" checksum="670FF8DF160E1B50" modified="2014-02-19" version="2">MANWTVALLIRRLPSLKNSFGRLTASQSIGDAIHSTVFAFIFSPMCFFSVEIMKTYSSAFGHILLIAYDISTYSHLCISLNRFCSIVAPIKYDTIFSMSNTKKLIMFSWACAVLPSFYLYIYQDCRFYYIEDFWVFTFSTTPVCNTIVWYADFLKYNSIVISIVIIDVITVSKVRSYKAGLSKTTSQSHEKKRSAEMNFLKQACLQAFVFVCELITYFLITPRVDGSERWLRFFLSTVAWVCVHMLDGVITLSFNKEFTQTIFRGIKIKDLSGHIGHHQENSSNAGATHTTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYI8</accession>
    <name>H2KYI8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">cgef-1</name>
        <name evidence="6" type="ORF">C14A11.3</name>
        <name evidence="4" type="ORF">CELE_C14A11.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123105.1">
        <property type="nucleotide sequence ID" value="NM_001129633.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYI8"/>
    <dbReference type="SMR" id="H2KYI8"/>
    <dbReference type="GeneID" id="180571"/>
    <dbReference type="KEGG" id="cel:CELE_C14A11.3"/>
    <dbReference type="AGR" id="WB:WBGene00006496"/>
    <dbReference type="CTD" id="180571"/>
    <dbReference type="WormBase" id="C14A11.3c">
        <property type="protein sequence ID" value="CE41760"/>
        <property type="gene ID" value="WBGene00006496"/>
        <property type="gene designation" value="cgef-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_592164_0_0_1"/>
    <dbReference type="OrthoDB" id="10004999at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006496">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYI8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000054">
        <property type="entry name" value="CDC-42 Guanine nucleotide Exchange Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000559">
        <property type="entry name" value="CDC-42 Guanine nucleotide Exchange Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF211">
        <property type="entry name" value="LD43457P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="65"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD63472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C14A11.3c"/>
        </source>
    </evidence>
    <sequence length="464" mass="53105" checksum="99194D08977565D4" modified="2012-03-21" version="1">MKRTLPRFLSFRRSKRRLITSVSAPLIVMNYHDGHQYELDSKDVPSCSGESTPAGTLSPRRETREVTNAFDEMIATEISYVADLKDIIIHYLEPFEATENQNSLPDTLRGKPDCLFGNVRELYKFHHRTVLEDLVAARSTAEMCRVLMQHRNQIYVTYRTYCQIHGSNQKVRDSVKNHPFFKECQRNANHNMDMSSYLLKPIQRIMKYQLLLGNIMDDCPADVRDEVAMTRDSMVELLNQIDASMQQLHISGYNGDLKSLGLLRLQTECDVFTYNRKKKAKLSRAQKRFIFFFDGAVMFCKKRVSNPGTTLNSEPEYFEHKFCIPIISLGYDTSSRTGASRFEVWDDAKTDAYVIETIDQTARTKWIQRLGKSETAQDACLENRQRPKSWASTVSNESSCSSSTRESDSTDSTMDTNGNTQTTQVDVPYSPTLDSSIDLSFQMDTTTPLRTSEINNEVELVDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYJ0</accession>
    <name>H2KYJ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUppressor of Tau pathology</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">sut-1</name>
        <name evidence="2" type="ORF">CELE_T13B5.8</name>
        <name evidence="4" type="ORF">T13B5.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD63491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_493917.2">
        <property type="nucleotide sequence ID" value="NM_061516.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYJ0"/>
    <dbReference type="SMR" id="H2KYJ0"/>
    <dbReference type="GeneID" id="173496"/>
    <dbReference type="AGR" id="WB:WBGene00020475"/>
    <dbReference type="CTD" id="173496"/>
    <dbReference type="WormBase" id="T13B5.8a">
        <property type="protein sequence ID" value="CE36017"/>
        <property type="gene ID" value="WBGene00020475"/>
        <property type="gene designation" value="sut-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5860800at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020475">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYJ0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T13B5.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYJ0"/>
        </source>
    </evidence>
    <sequence length="234" mass="26271" checksum="21D275B68CFF8435" modified="2012-03-21" version="1">MSGASKKVSEEELQKQYADYRAQFEQWKENNKGSIGTEAYNSYVQQFEQWEKEVEARTSQQQKHRKAAAVDKEAEAAAAAYAQSQEAYMAHHLRGMEQTEMQKRAAAAAQLQQQQMMQNMMMQRPPQHQQPPPQDVMFGAVGRVAQGAPAAAPPPTQQPPPQLWGNNKPIYDARDPLFAKWGERAASAHCKPETEQQINPVACWLLLDALREKKMVLAPHSNTCPPPQIGGHQI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYJ8-10</accession>
    <name>NHR66_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform j of Nuclear hormone receptor family member nhr-66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nhr-66</name>
        <name evidence="5" type="ORF">T09A12.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="e1002645" last="e1002645">
            <title>Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships.</title>
            <authorList>
                <person name="Pathare P.P."/>
                <person name="Lin A."/>
                <person name="Bornfeldt K.E."/>
                <person name="Taubert S."/>
                <person name="Van Gilst M.R."/>
            </authorList>
            <dbReference type="PubMed" id="22511885"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002645"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH NHR-49</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="Curr. Biol." volume="31" first="527" last="539.e7">
            <title>Dual Role of an mps-2/KCNE-Dependent Pathway in Long-Term Memory and Age-Dependent Memory Decline.</title>
            <authorList>
                <person name="Fenyves B.G."/>
                <person name="Arnold A."/>
                <person name="Gharat V.G."/>
                <person name="Haab C."/>
                <person name="Tishinov K."/>
                <person name="Peter F."/>
                <person name="de Quervain D."/>
                <person name="Papassotiropoulos A."/>
                <person name="Stetak A."/>
            </authorList>
            <dbReference type="PubMed" id="33259792"/>
            <dbReference type="DOI" id="10.1016/j.cub.2020.10.069"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KYJ8-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_061624 VSP_061623"/>
        </isoform>
        <isoform>
            <id>H2KYJ8-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_061621"/>
        </isoform>
        <isoform>
            <id>H2KYJ8-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061624 VSP_061622"/>
        </isoform>
        <isoform>
            <id>H2KYJ8-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_061620"/>
        </isoform>
        <isoform>
            <id>H2KYJ8-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_061622"/>
        </isoform>
        <isoform>
            <id>H2KYJ8-6</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_061624"/>
        </isoform>
        <isoform>
            <id>H2KYJ8-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_061621 VSP_061624"/>
        </isoform>
        <isoform>
            <id>H2KYJ8-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_061624 VSP_061620"/>
        </isoform>
        <isoform>
            <id>H2KYJ8-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_061623"/>
        </isoform>
        <isoform>
            <id>H2KYJ8-1</id>
            <name evidence="5">c</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001370926.1">
        <property type="nucleotide sequence ID" value="NM_001383139.1"/>
    </dbReference>
    <dbReference type="WormBase" id="T09A12.4j">
        <property type="protein sequence ID" value="CE49515"/>
        <property type="gene ID" value="WBGene00003656"/>
        <property type="gene designation" value="nhr-66"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T09A12.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T09A12.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T09A12.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T09A12.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T09A12.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T09A12.4f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T09A12.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T09A12.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T09A12.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T09A12.4j"/>
        </source>
    </evidence>
    <sequence length="528" mass="59004" checksum="2AD8DA7F5BEFF5E0" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYL2</accession>
    <name>H2KYL2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M13 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nep-16</name>
        <name evidence="6" type="ORF">CELE_F45E4.7</name>
        <name evidence="8" type="ORF">F45E4.7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD63783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023205.2">
        <property type="nucleotide sequence ID" value="NM_001028034.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYL2"/>
    <dbReference type="SMR" id="H2KYL2"/>
    <dbReference type="GeneID" id="177541"/>
    <dbReference type="AGR" id="WB:WBGene00018472"/>
    <dbReference type="CTD" id="177541"/>
    <dbReference type="WormBase" id="F45E4.7c">
        <property type="protein sequence ID" value="CE37645"/>
        <property type="gene ID" value="WBGene00018472"/>
        <property type="gene designation" value="nep-16"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5809267at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018472">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYL2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF206">
        <property type="entry name" value="PEPTIDASE M13 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003564299" evidence="4">
        <location>
            <begin position="28"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="5">
        <location>
            <begin position="172"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD63783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F45E4.7c"/>
        </source>
    </evidence>
    <sequence length="784" mass="90669" checksum="72ECE001AAC08C46" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2025-10-08" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>O62109</accession>
    <name>O62109_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">efsc-1</name>
        <name evidence="6" type="synonym">selb-1</name>
        <name evidence="6" type="ORF">C47B2.7</name>
        <name evidence="4" type="ORF">CELE_C47B2.7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB16863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T19991">
        <property type="entry name" value="T19991"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_493276.1">
        <property type="nucleotide sequence ID" value="NM_060875.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O62109"/>
    <dbReference type="SMR" id="O62109"/>
    <dbReference type="GeneID" id="173172"/>
    <dbReference type="UCSC" id="C47B2.7b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008133"/>
    <dbReference type="CTD" id="173172"/>
    <dbReference type="WormBase" id="C47B2.7a">
        <property type="protein sequence ID" value="CE17567"/>
        <property type="gene ID" value="WBGene00008133"/>
        <property type="gene designation" value="efsc-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008133">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O62109">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04094">
        <property type="entry name" value="eSelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03696">
        <property type="entry name" value="SelB_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000263">
        <property type="entry name" value="Eukaryotic Elongation Factor, SelenoCysteine-tRNA-specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049394">
        <property type="entry name" value="eEFSec_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049393">
        <property type="entry name" value="eEFSec_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF11">
        <property type="entry name" value="SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21131">
        <property type="entry name" value="eEFSec_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21208">
        <property type="entry name" value="euk_SelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="14"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Selenocysteine-specific elongation factor 3rd" evidence="3">
        <location>
            <begin position="256"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Selenocysteine-specific elongation factor C-terminal RIFT" evidence="2">
        <location>
            <begin position="363"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB16863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C47B2.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="O62109"/>
        </source>
    </evidence>
    <sequence length="459" mass="50627" checksum="C78F991B76270918" modified="1998-08-01" version="1">MTSPPSTSSSVGPLNLGILGHVDSGKTTLTRRIAELGSTSAFDAHATSTTTDGIRRNTLDLGFSTMTSLSGRRLALIDCPGHSGLIRAVLAASTVFDMAIVISESAKKVRKGLKSMGVDENSPIVEMSLADGYFKEEMLQNLKLAIESRIFEPKRDEEGEFLIAIDHCFAIKGQGTVLTGTVIRGVLRLNTEIEFPALNEKRRVKTLETWKQRVGQVAAGARAAFLVAPSFDEHRFSRCICGPLGTLKSTKFVLATVEPIQFFRKSINSKSKIHVAVAFETVMAECQFLKEKENGEFEMLPSLLAPCQVLFSFEKSIFLPENYSNPFMAARLEQQPGSGCRFAFSGIFSQILPENGKNLPPRFTRKCRKGHVERVEKDGFSAICTGMFKAETNFDVFRGFQICTSSGPRGKIEGAFGKSGKFRVTFAEKIDGILTEKEEISLFLKKYHNENRLVSYVPD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-10-01" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>P32743-2</accession>
    <name>YNH5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Uncharacterized protein R107.5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">R107.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P32743-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P32743-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_015949"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_499004.1">
        <property type="nucleotide sequence ID" value="NM_066603.8"/>
    </dbReference>
    <dbReference type="WormBase" id="R107.5a">
        <property type="protein sequence ID" value="CE00300"/>
        <property type="gene ID" value="WBGene00011300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="272" mass="31149" checksum="5087A6E56318FBB5" modified="2005-10-25" version="3">MTQLTNFSESFSNQNSNLHQPYNFNSHQPPEENHYYVREPNGKRPFPVEFELDMEYVPRTKRRFDKISACLENFSISNDKPSPINMESSSDEEMDEVYDDSNFDQCTESTSIPLVVEPDDEPAVAKKIRLDESIQRYFEKCRQGPIDFLPKPEKLKGNEMVIWQPRILVSPKNDFNMAGRIQEIDDEEEDRVNEEIKTRIIENEGMIDEDTRNETTGIVELGTGSDHSDIGSSWSSPMASPTGSSQIVELDPDSPNSLTNGSVTDEEMMEFE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>P34590-2</accession>
    <name>YN56_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Uncharacterized protein ZC21.6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZC21.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34590-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34590-2</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_061055"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367403.1">
        <property type="nucleotide sequence ID" value="NM_001379838.1"/>
    </dbReference>
    <dbReference type="WormBase" id="ZC21.6a">
        <property type="protein sequence ID" value="CE54098"/>
        <property type="gene ID" value="WBGene00022506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="ZC21.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="ZC21.6b"/>
        </source>
    </evidence>
    <sequence length="396" mass="44855" checksum="93B32B9C7C7422FB" modified="2021-06-02" version="3">MIPPPPNTSSLTCTPEEESENYKAVENMFATLYFFLPFSAFAALLANVIYLIVVTVGIRKGKLPLKRYALTINRTCADIFTILVGTYFYMKQKMDRCDSHICLPVETDMSRYVLQVVFVLNYWCVSLSYSGIAVLTNYAVRAPLQYKVNLTSMKVAKYILMGWIALLFCFLLCILLVHQGELDYNSNSVIHLFLDDFDSDEFIGEWLVDLCNHIKSHPGSRSLIVTILPPIVFYCISVVSYVFIIHLLFSRRKVSSYHRHWGSMLRLGIHLILFAGTCALTGTAYLGSFSIGDICENYKTNEPMCLDPVVLYMWNTAAALIGWICRMVIDATVDTVDIACFFVFHTKISCNKTSTGPSRKTESVQMESLMKIKPSRSRRLKINAQKSATIIEENIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2026-01-28" version="209" xmlns="https://uniprot.org/uniprot">
    <accession>Q06561-2</accession>
    <name>UNC52_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform a of Basement membrane proteoglycan</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Perlecan homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Uncoordinated protein 52</fullName>
            <shortName evidence="1 2">Protein unc-52</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">unc-52</name>
        <name evidence="7" type="ORF">ZC101.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Genes Dev." volume="7" first="1471" last="1484">
            <title>Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan.</title>
            <authorList>
                <person name="Rogalski T.M."/>
                <person name="Williams B.D."/>
                <person name="Mullen G.P."/>
                <person name="Moerman D.G."/>
            </authorList>
            <dbReference type="PubMed" id="8393416"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1999" name="Mol. Biol. Cell" volume="10" first="3205" last="3221">
            <title>Complex patterns of alternative splicing mediate the spatial and temporal distribution of perlecan/UNC-52 in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mullen G.P."/>
                <person name="Rogalski T.M."/>
                <person name="Bush J.A."/>
                <person name="Gorji P.R."/>
                <person name="Moerman D.G."/>
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            <dbReference type="PubMed" id="10512861"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 2451-3375 (ISOFORMS C/E)</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
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            <strain>Bristol N2</strain>
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    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Cell. Biol." volume="21" first="4985" last="4995">
            <title>Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans.</title>
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                <person name="Spike C.A."/>
                <person name="Shaw J.E."/>
                <person name="Herman R.K."/>
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            <dbReference type="PubMed" id="11438655"/>
            <dbReference type="DOI" id="10.1128/MCB.21.15.4985-4995.2001"/>
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        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="667" last="672">
            <title>Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Saito H."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Hirabayashi J."/>
                <person name="Kasai K."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
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            <dbReference type="PubMed" id="12754521"/>
            <dbReference type="DOI" id="10.1038/nbt829"/>
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        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1422</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="Development" volume="133" first="1263" last="1275">
            <title>FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dixon S.J."/>
                <person name="Alexander M."/>
                <person name="Fernandes R."/>
                <person name="Ricker N."/>
                <person name="Roy P.J."/>
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            <dbReference type="DOI" id="10.1242/dev.02300"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Dev. Dyn." volume="236" first="1093" last="1105">
            <title>Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.</title>
            <authorList>
                <person name="Ono K."/>
                <person name="Yu R."/>
                <person name="Ono S."/>
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            <dbReference type="PubMed" id="17326220"/>
            <dbReference type="DOI" id="10.1002/dvdy.21091"/>
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        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
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            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
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        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1422</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1002471" last="E1002471">
            <title>Calpains mediate integrin attachment complex maintenance of adult muscle in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Etheridge T."/>
                <person name="Oczypok E.A."/>
                <person name="Lehmann S."/>
                <person name="Fields B.D."/>
                <person name="Shephard F."/>
                <person name="Jacobson L.A."/>
                <person name="Szewczyk N.J."/>
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            <dbReference type="PubMed" id="22253611"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002471"/>
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        <scope>FUNCTION</scope>
        <scope>COMPONENT OF AN INTEGRIN CONTAINING ATTACHMENT COMPLEX</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="3" key="10">
        <citation type="journal article" date="2022" name="Science" volume="377" first="eabo3191" last="eabo3191">
            <title>Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.</title>
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                <person name="Bou Sleiman M."/>
                <person name="Roy S."/>
                <person name="Gao A.W."/>
                <person name="Sadler M.C."/>
                <person name="von Alvensleben G.V.G."/>
                <person name="Li H."/>
                <person name="Sen S."/>
                <person name="Harrison D.E."/>
                <person name="Nelson J.F."/>
                <person name="Strong R."/>
                <person name="Miller R.A."/>
                <person name="Kutalik Z."/>
                <person name="Williams R.W."/>
                <person name="Auwerx J."/>
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            <dbReference type="DOI" id="10.1126/science.abo3191"/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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        <citation type="journal article" date="1993" name="Genes Dev." volume="7" first="1471" last="1484">
            <title>Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan.</title>
            <authorList>
                <person name="Rogalski T.M."/>
                <person name="Williams B.D."/>
                <person name="Mullen G.P."/>
                <person name="Moerman D.G."/>
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            <dbReference type="PubMed" id="8393416"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
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        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
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    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="3">
        <citation type="journal article" date="1999" name="Mol. Biol. Cell" volume="10" first="3205" last="3221">
            <title>Complex patterns of alternative splicing mediate the spatial and temporal distribution of perlecan/UNC-52 in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mullen G.P."/>
                <person name="Rogalski T.M."/>
                <person name="Bush J.A."/>
                <person name="Gorji P.R."/>
                <person name="Moerman D.G."/>
            </authorList>
            <dbReference type="PubMed" id="10512861"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 2451-3375 (ISOFORMS C/E)</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Cell. Biol." volume="21" first="4985" last="4995">
            <title>Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Spike C.A."/>
                <person name="Shaw J.E."/>
                <person name="Herman R.K."/>
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            <dbReference type="PubMed" id="11438655"/>
            <dbReference type="DOI" id="10.1128/MCB.21.15.4985-4995.2001"/>
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        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="667" last="672">
            <title>Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Saito H."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Hirabayashi J."/>
                <person name="Kasai K."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
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            <dbReference type="PubMed" id="12754521"/>
            <dbReference type="DOI" id="10.1038/nbt829"/>
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        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1422</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
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    <reference key="6">
        <citation type="journal article" date="2006" name="Development" volume="133" first="1263" last="1275">
            <title>FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.</title>
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                <person name="Dixon S.J."/>
                <person name="Alexander M."/>
                <person name="Fernandes R."/>
                <person name="Ricker N."/>
                <person name="Roy P.J."/>
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            <dbReference type="DOI" id="10.1242/dev.02300"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Dev. Dyn." volume="236" first="1093" last="1105">
            <title>Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.</title>
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                <person name="Ono K."/>
                <person name="Yu R."/>
                <person name="Ono S."/>
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            <dbReference type="DOI" id="10.1002/dvdy.21091"/>
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        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference key="8">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
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                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
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            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
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        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1422</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
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    <reference key="9">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1002471" last="E1002471">
            <title>Calpains mediate integrin attachment complex maintenance of adult muscle in Caenorhabditis elegans.</title>
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                <person name="Etheridge T."/>
                <person name="Oczypok E.A."/>
                <person name="Lehmann S."/>
                <person name="Fields B.D."/>
                <person name="Shephard F."/>
                <person name="Jacobson L.A."/>
                <person name="Szewczyk N.J."/>
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            <dbReference type="PubMed" id="22253611"/>
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        <scope>FUNCTION</scope>
        <scope>COMPONENT OF AN INTEGRIN CONTAINING ATTACHMENT COMPLEX</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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        <citation type="journal article" date="2022" name="Science" volume="377" first="eabo3191" last="eabo3191">
            <title>Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.</title>
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                <person name="Bou Sleiman M."/>
                <person name="Roy S."/>
                <person name="Gao A.W."/>
                <person name="Sadler M.C."/>
                <person name="von Alvensleben G.V.G."/>
                <person name="Li H."/>
                <person name="Sen S."/>
                <person name="Harrison D.E."/>
                <person name="Nelson J.F."/>
                <person name="Strong R."/>
                <person name="Miller R.A."/>
                <person name="Kutalik Z."/>
                <person name="Williams R.W."/>
                <person name="Auwerx J."/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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        <citation type="journal article" date="1993" name="Genes Dev." volume="7" first="1471" last="1484">
            <title>Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan.</title>
            <authorList>
                <person name="Rogalski T.M."/>
                <person name="Williams B.D."/>
                <person name="Mullen G.P."/>
                <person name="Moerman D.G."/>
            </authorList>
            <dbReference type="PubMed" id="8393416"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1999" name="Mol. Biol. Cell" volume="10" first="3205" last="3221">
            <title>Complex patterns of alternative splicing mediate the spatial and temporal distribution of perlecan/UNC-52 in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mullen G.P."/>
                <person name="Rogalski T.M."/>
                <person name="Bush J.A."/>
                <person name="Gorji P.R."/>
                <person name="Moerman D.G."/>
            </authorList>
            <dbReference type="PubMed" id="10512861"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 2451-3375 (ISOFORMS C/E)</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Cell. Biol." volume="21" first="4985" last="4995">
            <title>Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Spike C.A."/>
                <person name="Shaw J.E."/>
                <person name="Herman R.K."/>
            </authorList>
            <dbReference type="PubMed" id="11438655"/>
            <dbReference type="DOI" id="10.1128/MCB.21.15.4985-4995.2001"/>
        </citation>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="667" last="672">
            <title>Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Saito H."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Hirabayashi J."/>
                <person name="Kasai K."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="12754521"/>
            <dbReference type="DOI" id="10.1038/nbt829"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1422</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="Development" volume="133" first="1263" last="1275">
            <title>FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dixon S.J."/>
                <person name="Alexander M."/>
                <person name="Fernandes R."/>
                <person name="Ricker N."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="16495308"/>
            <dbReference type="DOI" id="10.1242/dev.02300"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Dev. Dyn." volume="236" first="1093" last="1105">
            <title>Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.</title>
            <authorList>
                <person name="Ono K."/>
                <person name="Yu R."/>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="17326220"/>
            <dbReference type="DOI" id="10.1002/dvdy.21091"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1422</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1002471" last="E1002471">
            <title>Calpains mediate integrin attachment complex maintenance of adult muscle in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Etheridge T."/>
                <person name="Oczypok E.A."/>
                <person name="Lehmann S."/>
                <person name="Fields B.D."/>
                <person name="Shephard F."/>
                <person name="Jacobson L.A."/>
                <person name="Szewczyk N.J."/>
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            <dbReference type="PubMed" id="22253611"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002471"/>
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        <scope>FUNCTION</scope>
        <scope>COMPONENT OF AN INTEGRIN CONTAINING ATTACHMENT COMPLEX</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="10">
        <citation type="journal article" date="2022" name="Science" volume="377" first="eabo3191" last="eabo3191">
            <title>Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.</title>
            <authorList>
                <person name="Bou Sleiman M."/>
                <person name="Roy S."/>
                <person name="Gao A.W."/>
                <person name="Sadler M.C."/>
                <person name="von Alvensleben G.V.G."/>
                <person name="Li H."/>
                <person name="Sen S."/>
                <person name="Harrison D.E."/>
                <person name="Nelson J.F."/>
                <person name="Strong R."/>
                <person name="Miller R.A."/>
                <person name="Kutalik Z."/>
                <person name="Williams R.W."/>
                <person name="Auwerx J."/>
            </authorList>
            <dbReference type="PubMed" id="36173858"/>
            <dbReference type="DOI" id="10.1126/science.abo3191"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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            <taxon>Rhabditomorpha</taxon>
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    <reference key="1">
        <citation type="journal article" date="1993" name="Genes Dev." volume="7" first="1471" last="1484">
            <title>Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan.</title>
            <authorList>
                <person name="Rogalski T.M."/>
                <person name="Williams B.D."/>
                <person name="Mullen G.P."/>
                <person name="Moerman D.G."/>
            </authorList>
            <dbReference type="PubMed" id="8393416"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1999" name="Mol. Biol. Cell" volume="10" first="3205" last="3221">
            <title>Complex patterns of alternative splicing mediate the spatial and temporal distribution of perlecan/UNC-52 in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mullen G.P."/>
                <person name="Rogalski T.M."/>
                <person name="Bush J.A."/>
                <person name="Gorji P.R."/>
                <person name="Moerman D.G."/>
            </authorList>
            <dbReference type="PubMed" id="10512861"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 2451-3375 (ISOFORMS C/E)</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Cell. Biol." volume="21" first="4985" last="4995">
            <title>Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Spike C.A."/>
                <person name="Shaw J.E."/>
                <person name="Herman R.K."/>
            </authorList>
            <dbReference type="PubMed" id="11438655"/>
            <dbReference type="DOI" id="10.1128/MCB.21.15.4985-4995.2001"/>
        </citation>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="667" last="672">
            <title>Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Saito H."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Hirabayashi J."/>
                <person name="Kasai K."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="12754521"/>
            <dbReference type="DOI" id="10.1038/nbt829"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1422</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="Development" volume="133" first="1263" last="1275">
            <title>FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dixon S.J."/>
                <person name="Alexander M."/>
                <person name="Fernandes R."/>
                <person name="Ricker N."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="16495308"/>
            <dbReference type="DOI" id="10.1242/dev.02300"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Dev. Dyn." volume="236" first="1093" last="1105">
            <title>Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.</title>
            <authorList>
                <person name="Ono K."/>
                <person name="Yu R."/>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="17326220"/>
            <dbReference type="DOI" id="10.1002/dvdy.21091"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
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        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1422</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1002471" last="E1002471">
            <title>Calpains mediate integrin attachment complex maintenance of adult muscle in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Etheridge T."/>
                <person name="Oczypok E.A."/>
                <person name="Lehmann S."/>
                <person name="Fields B.D."/>
                <person name="Shephard F."/>
                <person name="Jacobson L.A."/>
                <person name="Szewczyk N.J."/>
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            <dbReference type="PubMed" id="22253611"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002471"/>
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        <scope>FUNCTION</scope>
        <scope>COMPONENT OF AN INTEGRIN CONTAINING ATTACHMENT COMPLEX</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="3" key="10">
        <citation type="journal article" date="2022" name="Science" volume="377" first="eabo3191" last="eabo3191">
            <title>Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.</title>
            <authorList>
                <person name="Bou Sleiman M."/>
                <person name="Roy S."/>
                <person name="Gao A.W."/>
                <person name="Sadler M.C."/>
                <person name="von Alvensleben G.V.G."/>
                <person name="Li H."/>
                <person name="Sen S."/>
                <person name="Harrison D.E."/>
                <person name="Nelson J.F."/>
                <person name="Strong R."/>
                <person name="Miller R.A."/>
                <person name="Kutalik Z."/>
                <person name="Williams R.W."/>
                <person name="Auwerx J."/>
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            <dbReference type="PubMed" id="36173858"/>
            <dbReference type="DOI" id="10.1126/science.abo3191"/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of KH domain-containing protein akap-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">akap-1</name>
        <name evidence="2" type="ORF">C56G2.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09285-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09285-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_002856 VSP_002857"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741191.1">
        <property type="nucleotide sequence ID" value="NM_171164.7"/>
    </dbReference>
    <dbReference type="WormBase" id="C56G2.1b">
        <property type="protein sequence ID" value="CE30637"/>
        <property type="gene ID" value="WBGene00016977"/>
        <property type="gene designation" value="akap-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C56G2.1a"/>
        </source>
    </evidence>
    <sequence length="409" mass="46067" checksum="B5A1193CE50D9D2A" modified="2002-11-25" version="2">MKVYAKVQEEVKTRRLRKNSTTSSGYGYSVPMTPNTEILFDTASSQDSGRATGPLASPHEDGLTTEDDFLPMYEFEIPNSLVGLIIGVKGKTIKELSVRTNVRMLIRQHHETDKVKTHQICQVRGKRDEINHCLQMLRRRFPPARFPELNLQPVVPPVLPNSNFDMLSTQPTWLTLPEDIKCEVAVSSIISASHFFIQQPTHPSFASLRHLDMYMGSLYGEQSNLPELPIPCQNGLLCAAPVGNAWFRAVTVQYFDETDEVFVKFVDYGGYSKMARQDLRQIRTDLMSLPFQSTEVMLAHVRPVDGTTNWSDAAMQKFRAMCIGKVINCKMVGQSHDTRIPMVELYMMSKDGKDAQEVRFDQVLMNCGLARTADPSKMSRITVPAALDTESRMKRPSFSSQTSQTAVVC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q19143-2</accession>
    <name>KBRAS_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of NF-kappa-B inhibitor-interacting Ras-like protein</fullName>
            <shortName>Kappa B-Ras</shortName>
            <shortName>KappaB-Ras</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kbrl-1</name>
        <name evidence="2" type="ORF">F52A8.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19143-2</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_038728"/>
        </isoform>
        <isoform>
            <id>Q19143-1</id>
            <name evidence="2">c</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_492076.1">
        <property type="nucleotide sequence ID" value="NM_059675.7"/>
    </dbReference>
    <dbReference type="WormBase" id="F52A8.6a">
        <property type="protein sequence ID" value="CE20840"/>
        <property type="gene ID" value="WBGene00009919"/>
        <property type="gene designation" value="kbrl-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="F52A8.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F52A8.6c"/>
        </source>
    </evidence>
    <sequence length="364" mass="41629" checksum="0DD706A61896912E" modified="2006-03-07" version="4">MLKLKNKHVKTGKCANTPTRFHRRCIRVGDNLTNKRVRFFGSASNSCEFLYYLFKENWIRPSSRKFSLGVTPRALSRIDATSTPSLDVPQKATNRRFSLAATFFDAAKADRKTSLCVEKDYLNHQGRYRTVADPDLERPLFVERSEEKGVRTFRSDSIKPARSRRMGRAMRVVVVGGKKVGKTAILRQVACVEDVTNKPYEPTIEDTYQVLLEEPDKAREILILHDTAGVSNYGPIELKKAYVQAADAFVLVYSSADYESFNRVDLLKKWIDRQFGKDKKEVPIVVLANMRDRPATVDSAFAHSWAAREKVKLFEVTAKDRQSLVDFIHYVGHRHFHPTKESKFSLSKKLKSEKSSNPAILMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q564X1</accession>
    <name>Q564X1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">IntraMembrane Protease (IMPAS) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">imp-1</name>
        <name evidence="12" type="ORF">C36B1.12</name>
        <name evidence="10" type="ORF">CELE_C36B1.12</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAI79137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021024.1">
        <property type="nucleotide sequence ID" value="NM_001025853.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q564X1"/>
    <dbReference type="MEROPS" id="A22.A08"/>
    <dbReference type="GeneID" id="172684"/>
    <dbReference type="UCSC" id="C36B1.12c.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007979"/>
    <dbReference type="CTD" id="172684"/>
    <dbReference type="WormBase" id="C36B1.12b">
        <property type="protein sequence ID" value="CE38290"/>
        <property type="gene ID" value="WBGene00007979"/>
        <property type="gene designation" value="imp-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436338_0_0_1"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007979">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q564X1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF103">
        <property type="entry name" value="INTRAMEMBRANE PROTEASE (IMPAS) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004250811" evidence="9">
        <location>
            <begin position="23"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAI79137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C36B1.12b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="Q564X1"/>
        </source>
    </evidence>
    <sequence length="640" mass="72242" checksum="F75DD80DA6A98480" modified="2005-05-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q564Y4</accession>
    <name>Q564Y4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein sleepless</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">nssp-70</name>
        <name evidence="5" type="ORF">C30G7.2</name>
        <name evidence="3" type="ORF">CELE_C30G7.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAI79140.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256634.2">
        <property type="nucleotide sequence ID" value="NM_001269705.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q564Y4"/>
    <dbReference type="GeneID" id="3565427"/>
    <dbReference type="UCSC" id="C30G7.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00044176"/>
    <dbReference type="CTD" id="3565427"/>
    <dbReference type="WormBase" id="C30G7.2a">
        <property type="protein sequence ID" value="CE48034"/>
        <property type="gene ID" value="WBGene00044176"/>
        <property type="gene designation" value="nssp-70"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428346at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044176">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q564Y4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332">
        <property type="entry name" value="PROTEIN CBG11604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332:SF1">
        <property type="entry name" value="RE49668P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAI79140.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C30G7.2a"/>
        </source>
    </evidence>
    <sequence length="184" mass="20095" checksum="6141412FDC57F239" modified="2013-02-06" version="3">MSRLVCPSVKPSSSVLLLFPPIYKQFAVFLVLSLAVMEGVSGIGCFVCSSFDGENKGCEDPFNSTMDLSSRDRDASAVANYNYPCWAYKKGRHGLFPADHCIKIVGYRADNESKTLVIRTCALDSGTLTADTEIVRISHCGSFKYEGHQYKGCVQSCDTDGCNSSSVHSFLLPLCFLIVFSLLS</sequence>
</entry>
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    <accession>Q564Z6</accession>
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        <name evidence="3" type="ORF">CELE_D1054.9</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAI79165.3"/>
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    <dbReference type="AlphaFoldDB" id="Q564Z6"/>
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    <dbReference type="UCSC" id="D1054.9b.1">
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    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008376"/>
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    <dbReference type="WormBase" id="D1054.9e">
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        <property type="gene ID" value="WBGene00008376"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846958at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="17"/>
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            <begin position="18"/>
            <end position="533"/>
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        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
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        <location>
            <begin position="272"/>
            <end position="372"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="310"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAI79165.3"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="D1054.9e"/>
        </source>
    </evidence>
    <sequence length="533" mass="58043" checksum="1CAAE61A928B5D19" modified="2012-01-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q564Z7</accession>
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        <submittedName>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAI79164.3"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cel:CELE_D1054.9"/>
    <dbReference type="UCSC" id="D1054.9b.1">
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    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008376"/>
    <dbReference type="CTD" id="179495"/>
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        <property type="protein sequence ID" value="CE46776"/>
        <property type="gene ID" value="WBGene00008376"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5846958at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="17"/>
        </location>
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        <location>
            <begin position="18"/>
            <end position="529"/>
        </location>
    </feature>
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            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
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        <location>
            <begin position="272"/>
            <end position="365"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="201"/>
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        <location>
            <begin position="274"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAI79164.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="D1054.9d"/>
        </source>
    </evidence>
    <sequence length="529" mass="57982" checksum="4872A48E86721E51" modified="2012-01-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-02-15" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5H9M9</accession>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
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        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
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    </dbReference>
    <dbReference type="PeptideAtlas" id="Q5H9M9"/>
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    <dbReference type="WormBase" id="C09B8.6c">
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        <property type="gene ID" value="WBGene00002023"/>
        <property type="gene designation" value="hsp-25"/>
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    <dbReference type="Bgee" id="WBGene00002023">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q5H9M9">
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    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BMA-HSP-25, isoform c"/>
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    </dbReference>
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        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD63803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C09B8.6c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q5H9M9"/>
        </source>
    </evidence>
    <sequence length="108" mass="12417" checksum="D1B9767A472CBC8F" modified="2005-02-15" version="1">MAHRPTYDPYLDNLKSPLIKDESDGKTLRLRFDVANYKPEEVTVKTIDNRLLVHAKHEEKTPQRTVFREYNQEFLLPRGTNPEQISSTLSTDGVLTVEAPLPQLAIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z1N9</accession>
    <name>Q7Z1N9_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_D1007.10</name>
        <name evidence="1 3" type="ORF">D1007.10</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD67323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021069.1">
        <property type="nucleotide sequence ID" value="NM_001025898.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z1N9"/>
    <dbReference type="GeneID" id="183889"/>
    <dbReference type="UCSC" id="D1007.10c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017007"/>
    <dbReference type="CTD" id="183889"/>
    <dbReference type="WormBase" id="D1007.10c">
        <property type="protein sequence ID" value="CE34282"/>
        <property type="gene ID" value="WBGene00017007"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691237_0_0_1"/>
    <dbReference type="OrthoDB" id="5797982at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017007">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z1N9">
        <property type="expression patterns" value="baseline and differential"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039934">
        <property type="entry name" value="C2CD2/C2CD2L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119:SF5">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004295103" evidence="4">
        <location>
            <begin position="29"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="297"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="724"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="580"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD62667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="R11G1.6c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q7Z1P9"/>
        </source>
    </evidence>
    <sequence length="811" mass="91453" checksum="6B3AFE35DAD9BD76" modified="2003-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z1Q2</accession>
    <name>Q7Z1Q2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">alh-12</name>
        <name evidence="4" type="ORF">CELE_Y69F12A.2</name>
        <name evidence="6" type="ORF">Y69F12A.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD72350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370775.1">
        <property type="nucleotide sequence ID" value="NM_001382916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z1Q2"/>
    <dbReference type="SMR" id="Q7Z1Q2"/>
    <dbReference type="PeptideAtlas" id="Q7Z1Q2"/>
    <dbReference type="GeneID" id="176056"/>
    <dbReference type="UCSC" id="Y69F12A.2a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000118"/>
    <dbReference type="CTD" id="176056"/>
    <dbReference type="WormBase" id="Y69F12A.2b">
        <property type="protein sequence ID" value="CE34423"/>
        <property type="gene ID" value="WBGene00000118"/>
        <property type="gene designation" value="alh-12"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000118">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z1Q2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD72350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y69F12A.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q7Z1Q2"/>
        </source>
    </evidence>
    <sequence length="430" mass="45562" checksum="352E3434D5EFFF1B" modified="2003-10-01" version="1">MVFTVPSDLSGGLYFLNGKRTTIESTETFDVIEPRIGQVVAKCPKATADIVDQYVKAAADAQSAWGETTALDRGKVLHKVADLIREHAEEIAIWEVKTNGKPIYEARCDIASSADTFDFFGGIATAVLQGDSLELPGGPSQRIAYTRREPYGVVGCIGAWNYPFQTCVWKVAPALAAGNAVVYKPSPFAPASPVLLGEILTAAGVPKGVYNVIQGEQEAGVALCEHNLVAKVSFTGSVASGEAVQRQAATKNVKPVTLELGGKSEIIIFDDSDVKSAVASAMLANFLNQGQVCTNATRVFVQKGILASFTEAIVQEANDKLKVGDPLLEDTRVGANINEGHLQRILGYVESAKQEGGVVLRGGVRVHPTGVEGGAYFEPAIITGLSDEARAVREEIFGAVMLILPFETEEEVIARANNTTYGLAAGVFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z1Q7</accession>
    <name>Q7Z1Q7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y82E9BR.17</name>
        <name evidence="1 3" type="ORF">Y82E9BR.17</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z1Q7"/>
    <dbReference type="UCSC" id="Y82E9BR.17b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022349"/>
    <dbReference type="WormBase" id="Y82E9BR.17b">
        <property type="protein sequence ID" value="CE42918"/>
        <property type="gene ID" value="WBGene00022349"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564112_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022349">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z1Q7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD73055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y82E9BR.17b"/>
        </source>
    </evidence>
    <sequence length="101" mass="11678" checksum="ED17F89FA379B0D3" modified="2008-09-23" version="2">MSNYDNRFVDLGTFFLQSNGICVEQFKMKNGCVIDKEGLEQAKDNGFQIVCTKCAFKCITVTSFNLHFYFKHADWDNDQKPLPIEDFAIVDDIFESSFEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z1Q8</accession>
    <name>Q7Z1Q8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">lelo-2</name>
        <name evidence="8" type="ORF">CELE_Y82E9BR.16</name>
        <name evidence="10" type="ORF">Y82E9BR.16</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367979.1">
        <property type="nucleotide sequence ID" value="NM_001381733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z1Q8"/>
    <dbReference type="SMR" id="Q7Z1Q8"/>
    <dbReference type="PeptideAtlas" id="Q7Z1Q8"/>
    <dbReference type="GeneID" id="175300"/>
    <dbReference type="KEGG" id="cel:CELE_Y82E9BR.16"/>
    <dbReference type="UCSC" id="Y82E9BR.16a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022348"/>
    <dbReference type="CTD" id="175300"/>
    <dbReference type="WormBase" id="Y82E9BR.16b">
        <property type="protein sequence ID" value="CE23368"/>
        <property type="gene ID" value="WBGene00022348"/>
        <property type="gene designation" value="lelo-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_33_4_1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022348">
        <property type="expression patterns" value="Expressed in material anatomical entity and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z1Q8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD73049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y82E9BR.16b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q7Z1Q8"/>
        </source>
    </evidence>
    <sequence length="132" mass="14480" checksum="AECDEAEC356B40DC" modified="2003-10-01" version="1">MGDNVQLWMAITQMAFTKGSITGVYAAIYTYSPELFPTVIRNTAMGFCSTIARVGAIAASYISMWIAEQFGKVFMIIPFGCMAVLAAVMTLLFLPETMGKPLPESIEEIEEGDSYRSSHEMQPLSKSTEETA</sequence>
</entry>
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    <accession>Q7Z1R1</accession>
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        <submittedName>
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        <name type="scientific">Caenorhabditis elegans</name>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD71354.1"/>
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    <dbReference type="WormBase" id="F46H5.2c">
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        <property type="gene ID" value="WBGene00018518"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625906_0_0_1"/>
    <dbReference type="OrthoDB" id="10036177at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF6">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="67"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
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        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
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        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD71354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F46H5.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q7Z1R1"/>
        </source>
    </evidence>
    <sequence length="374" mass="40798" checksum="F4DC91BC4766BE89" modified="2003-10-01" version="1">MDQCEASASNSSCPSTGSNSNSNNSNANAKLGATFNHGEDIPPASSPATSISSVISEQSEAFRNSPYHAQSPLSAVLFQRPDFLSSEGDRPMSYPSMSSFSTNVPDSENSSRSSVDGYNLKDTTSEKIKQFRENNKRKTSNSSSEEEPETEEGDPSRKLSSKSAEDKFVGRGIDAPRGRIANIRRESSCSVDSEAAHERLTKASQQVSTGFDDIALDSERSPGTSAEFRRRAPSFNTVIGEPISVVTNAFIPHSCSPSPTRQQADLIKQCYSPSTQQMVRPNISYSPSPRESPAQSPTRHAHKLKFQRAESPICRQPIKRKLTVTTLAETDIKRLFVPRSNTSPLVTDKTFPYPQNVGQLFESASTSSEFSSFS</sequence>
</entry>
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    <accession>Q7Z1R2</accession>
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        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM122 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD71353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024675.1">
        <property type="nucleotide sequence ID" value="NM_001029504.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z1R2"/>
    <dbReference type="PeptideAtlas" id="Q7Z1R2"/>
    <dbReference type="GeneID" id="180989"/>
    <dbReference type="KEGG" id="cel:CELE_F46H5.2"/>
    <dbReference type="UCSC" id="F46H5.2b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018518"/>
    <dbReference type="CTD" id="180989"/>
    <dbReference type="WormBase" id="F46H5.2b">
        <property type="protein sequence ID" value="CE34024"/>
        <property type="gene ID" value="WBGene00018518"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10036177at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018518">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z1R2">
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    </dbReference>
    <dbReference type="GO" id="GO:0016301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF6">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="272"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="25"/>
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    </feature>
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        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
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            <begin position="272"/>
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        </location>
    </feature>
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        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD71353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F46H5.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q7Z1R2"/>
        </source>
    </evidence>
    <sequence length="362" mass="39931" checksum="CCCDE3A056245A76" modified="2003-10-01" version="1">MSYPSMSSFSTNVPDSENSSRSSVDGYNLKDTTSEKIKQFRENNKRKTSNSSSEEEPETEEGDPSRKLSSKSAEDKFVGRGIDAPRGRIANIRRESSCSVDSEAAHERLTKASQQVSTGFDDIALDSERSPGTSAEFRRRAPSFNTVIGEPISVVTNAFIPHSCSPSPTRQQADLIKQCYSPSTQQMVRPNISYSPSPRESPAQSPTRHAHKLKFQRAESPICRQPIKRKLTVTTLAETDIKRLFVPRSNTSPLVTDKTFPYPQNVGQLFESASTSSEFSSFSVPHSPGPLRAMTPLSSVSVGDQEENSPSVKDAEEKTTDNDEEMQDVEMSDNGTEVDDDLIRAATEAPLPDDDDQNDFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q7Z204</accession>
    <name>Q7Z204_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">sup-26</name>
        <name evidence="2" type="ORF">CELE_R10E4.2</name>
        <name evidence="4" type="ORF">R10E4.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAD91698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022716.1">
        <property type="nucleotide sequence ID" value="NM_001027545.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7Z204"/>
    <dbReference type="PeptideAtlas" id="Q7Z204"/>
    <dbReference type="GeneID" id="175551"/>
    <dbReference type="KEGG" id="cel:CELE_R10E4.2"/>
    <dbReference type="UCSC" id="R10E4.2a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006331"/>
    <dbReference type="CTD" id="175551"/>
    <dbReference type="WormBase" id="R10E4.2c">
        <property type="protein sequence ID" value="CE34085"/>
        <property type="gene ID" value="WBGene00006331"/>
        <property type="gene designation" value="sup-26"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146229_0_0_1"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006331">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7Z204">
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD91698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R10E4.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q7Z204"/>
        </source>
    </evidence>
    <sequence length="150" mass="16568" checksum="DFE6179503067C39" modified="2003-10-01" version="1">MNASSAPQQQQQQQQPQQGQAPQQQQQGPPQHQYQQQRPFHGHSMNNPEMLQRMQYPQVYQSYYGYHPAAVYQQHYDVNSLASQMGGMHVGGGNPQANGGGDMYGAHMYGQNAGGQGGQGVGQGGQGGNQQFYNPNNGRNKKYFQPMNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q86DB4</accession>
    <name>Q86DB4_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">eat-18</name>
        <name evidence="2" type="ORF">CELE_EAT-18</name>
        <name evidence="4" type="ORF">Y105E8A.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAD88218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021693.1">
        <property type="nucleotide sequence ID" value="NM_001026522.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86DB4"/>
    <dbReference type="SMR" id="Q86DB4"/>
    <dbReference type="GeneID" id="24105308"/>
    <dbReference type="KEGG" id="cel:CELE_EAT-18"/>
    <dbReference type="UCSC" id="Y105E8A.7d">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001147"/>
    <dbReference type="CTD" id="24105308"/>
    <dbReference type="WormBase" id="Y105E8A.7c">
        <property type="protein sequence ID" value="CE33723"/>
        <property type="gene ID" value="WBGene00001147"/>
        <property type="gene designation" value="eat-18"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2624241_0_0_1"/>
    <dbReference type="OrthoDB" id="6022136at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001147">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86DB4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043051">
        <property type="term" value="P:regulation of nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD88218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y105E8A.7c"/>
        </source>
    </evidence>
    <sequence length="71" mass="8397" checksum="7E008FAA558F5C58" modified="2003-06-01" version="1">MRSLERIVETRIELLEWDSKETKEDCARCRALDCDIIFALLFTIVIACLLVLIMVFWLKGVLQYEEMRSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q86DC0</accession>
    <name>Q86DC0_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C46H3.2</name>
        <name evidence="3" type="ORF">CELE_C46H3.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD65701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359896.1">
        <property type="nucleotide sequence ID" value="NM_001373221.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86DC0"/>
    <dbReference type="SMR" id="Q86DC0"/>
    <dbReference type="GeneID" id="3564865"/>
    <dbReference type="UCSC" id="C46H3.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016725"/>
    <dbReference type="CTD" id="3564865"/>
    <dbReference type="WormBase" id="C46H3.2b">
        <property type="protein sequence ID" value="CE33921"/>
        <property type="gene ID" value="WBGene00016725"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014129_0_0_1"/>
    <dbReference type="OrthoDB" id="5314041at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016725">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86DC0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd09497">
        <property type="entry name" value="SAM_caskin1_2_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09498">
        <property type="entry name" value="SAM_caskin1_2_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000071">
        <property type="entry name" value="Caskin, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000028">
        <property type="entry name" value="caskin-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035497">
        <property type="entry name" value="Caskin1/2_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035498">
        <property type="entry name" value="Caskin1/2_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155:SF11">
        <property type="entry name" value="CASKIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155">
        <property type="entry name" value="OSTEOCLAST-STIMULATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="197"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="267"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD65701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C46H3.2b"/>
        </source>
    </evidence>
    <sequence length="577" mass="62835" checksum="909DBDADFA1A735C" modified="2003-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q86DC5</accession>
    <name>Q86DC5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent RNA helicase RhlE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_R04E5.8</name>
        <name evidence="2 4" type="ORF">R04E5.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD65957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86DC5"/>
    <dbReference type="UCSC" id="R04E5.8a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019871"/>
    <dbReference type="WormBase" id="R04E5.8b">
        <property type="protein sequence ID" value="CE33934"/>
        <property type="gene ID" value="WBGene00019871"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1817518_0_0_1"/>
    <dbReference type="OrthoDB" id="10675309at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019871">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86DC5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R04E5.8b"/>
        </source>
    </evidence>
    <sequence length="142" mass="16993" checksum="C1B7E9AFAB102D3D" modified="2003-06-01" version="1">MHLARMVRDQIEREGGEALEPAETEYSHFAHDTSGRGRHQQNDGYRGDRRHRSPGKHIAPARAHNRGQHHNRGHHHGPPRNHNQDRNRHRNHDGNRHQNQDRSRHHNQDRNRRQNHDRNRHQSQGRNRQQDHERGDEAHEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2025-10-08" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q86DD0</accession>
    <name>Q86DD0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y42G9A.3</name>
        <name evidence="3 5" type="ORF">Y42G9A.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD71153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022865.1">
        <property type="nucleotide sequence ID" value="NM_001027694.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86DD0"/>
    <dbReference type="SMR" id="Q86DD0"/>
    <dbReference type="GeneID" id="175865"/>
    <dbReference type="UCSC" id="Y42G9A.3b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021533"/>
    <dbReference type="CTD" id="175865"/>
    <dbReference type="WormBase" id="Y42G9A.3b">
        <property type="protein sequence ID" value="CE33945"/>
        <property type="gene ID" value="WBGene00021533"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_18_2_1"/>
    <dbReference type="OrthoDB" id="1053178at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021533">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86DD0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD71153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y42G9A.3b"/>
        </source>
    </evidence>
    <sequence length="295" mass="33299" checksum="DD684A1B0420720E" modified="2003-06-01" version="1">MSDTPSTSSVFLPTWPTRRTDANLYPNGSTKSDELVLHDYGLEEIPMRYHIEQPEEDYDPQNVKKLDLTHNSFVILRGLTTFNNVSVLDVSFNSLSALPEDIGTLSSLTTLIARNNLLEHLPKGLQLLENLEHLYLSGNRLEYVPPVILTMRKLKTLHLGGNYIDSCPSNISVLTLLRVLYLGGNRLREIPASIGCLDELENLGLCDNILETIPSTLGDLHYLETLSLHNNRLRTLPTDILNLRRLQQLSLRNNPLVHSFVHNMDLAPPSLKELSGRTVRQNYHKVPNLDEILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q86DD2</accession>
    <name>Q86DD2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inappropriate Vulval cell Proliferation Homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">ivph-3</name>
        <name evidence="2" type="ORF">CELE_Y67D8C.3</name>
        <name evidence="4" type="ORF">Y67D8C.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD74093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368058.1">
        <property type="nucleotide sequence ID" value="NM_001380125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86DD2"/>
    <dbReference type="SMR" id="Q86DD2"/>
    <dbReference type="PeptideAtlas" id="Q86DD2"/>
    <dbReference type="GeneID" id="177086"/>
    <dbReference type="UCSC" id="Y67D8C.3b.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022067"/>
    <dbReference type="CTD" id="177086"/>
    <dbReference type="WormBase" id="Y67D8C.3b">
        <property type="protein sequence ID" value="CE33951"/>
        <property type="gene ID" value="WBGene00022067"/>
        <property type="gene designation" value="ivph-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020701_0_0_1"/>
    <dbReference type="OrthoDB" id="5784093at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022067">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86DD2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040027">
        <property type="term" value="P:negative regulation of vulval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040129">
        <property type="entry name" value="Lin-15B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22716">
        <property type="entry name" value="ETS CLASS TRANSCRIPTION FACTOR-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22716:SF5">
        <property type="entry name" value="INAPPROPRIATE VULVAL CELL PROLIFERATION HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD74093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y67D8C.3b"/>
        </source>
    </evidence>
    <sequence length="612" mass="70216" checksum="3C145E38BB79BB41" modified="2003-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q86DD3</accession>
    <name>Q86DD3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">epg-9</name>
        <name evidence="4" type="ORF">CELE_Y69A2AR.7</name>
        <name evidence="6" type="ORF">Y69A2AR.7</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD74115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023565.1">
        <property type="nucleotide sequence ID" value="NM_001028394.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86DD3"/>
    <dbReference type="SMR" id="Q86DD3"/>
    <dbReference type="GeneID" id="177040"/>
    <dbReference type="KEGG" id="cel:CELE_Y69A2AR.7"/>
    <dbReference type="UCSC" id="Y69A2AR.7a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022078"/>
    <dbReference type="CTD" id="177040"/>
    <dbReference type="WormBase" id="Y69A2AR.7c">
        <property type="protein sequence ID" value="CE33953"/>
        <property type="gene ID" value="WBGene00022078"/>
        <property type="gene designation" value="epg-9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110397_0_0_1"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022078">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86DD3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD74115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y69A2AR.7c"/>
        </source>
    </evidence>
    <sequence length="187" mass="20986" checksum="E80BEF3C42E9EA72" modified="2003-06-01" version="1">MCVDEDIRQFKCEVEEATCSGSIPRRTPTVGSPTDSAIPLLSAQIGLQFYTKSKKPNSVIGTAVTWFGGAAATATGATVADDGTSWEEWKLILDVFRVESIDELQKMRQRVADDIGEKVLDICEHINHNHYTPKMPTKTEIPEIFETKFSDCQPYLFKIRRQAVPQMEHKQSLAQVALSRWKDILAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-06-01" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q86DD5</accession>
    <name>Q86DD5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prion-like-(Q/N-rich)-domain-bearing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pqn-89</name>
        <name evidence="4" type="ORF">CELE_Y73B6BR.1</name>
        <name evidence="6" type="ORF">Y73B6BR.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD62457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370356.1">
        <property type="nucleotide sequence ID" value="NM_001383105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86DD5"/>
    <dbReference type="PeptideAtlas" id="Q86DD5"/>
    <dbReference type="GeneID" id="177412"/>
    <dbReference type="UCSC" id="Y73B6BR.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004169"/>
    <dbReference type="CTD" id="177412"/>
    <dbReference type="WormBase" id="Y73B6BR.1b">
        <property type="protein sequence ID" value="CE42205"/>
        <property type="gene ID" value="WBGene00004169"/>
        <property type="gene designation" value="pqn-89"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855624at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004169">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q86DD5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0640">Prion</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004302321" evidence="3">
        <location>
            <begin position="23"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD62457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y73B6BR.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q86DD5"/>
        </source>
    </evidence>
    <sequence length="454" mass="49873" checksum="C3164386204821DD" modified="2012-01-25" version="2">MITRRIVSFLTCLSLLSLTINAQYQVNSQNQNPYQQQQYGQQTQNQQQNRNQNTNTNTNTGYGTQSQNYGNANSNSWGSAAANVANTLQTGYQNIQNRGLFNNQSPFGATSNNTNSNSNKGVTIQFQLRGYSNPSSALPNSQTCTCPSGYTCSFLKTSPRCYFAFTFIVSSPDESVRYQITDFFYLDTNGQLPQSSQGQWSQNYVMNLPSKPAAIDVFAHHLGAVITQTGQLVQDDTLTHVDTFVVPLSDTLPAVEGVQNMNQQRTYQGKLLGTSLSMSFSISCSGSLIGPSCDLTCKASHVNANVAACVSNSTGFFSICNYITNGQVDNCKNCPWGIKDNTYCQDDHGSVLDPSEAGLVGMGWRTATIILAILTFLFLLLLCALALFTCVRSRQAPAEKEMTTFNRTSSDREPLHSEKHREAAAYRQDSTDRRPMMPPAQDAKPINDPLYTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXF9</accession>
    <name>Q8MXF9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_ZK1055.6</name>
        <name evidence="1 3" type="ORF">ZK1055.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD68851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741556.1">
        <property type="nucleotide sequence ID" value="NM_171474.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXF9"/>
    <dbReference type="PeptideAtlas" id="Q8MXF9"/>
    <dbReference type="GeneID" id="179050"/>
    <dbReference type="UCSC" id="ZK1055.6b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022847"/>
    <dbReference type="CTD" id="179050"/>
    <dbReference type="WormBase" id="ZK1055.6c">
        <property type="protein sequence ID" value="CE31138"/>
        <property type="gene ID" value="WBGene00022847"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3070701_0_0_1"/>
    <dbReference type="OrthoDB" id="10068793at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022847">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXF9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD68851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="ZK1055.6c"/>
        </source>
    </evidence>
    <sequence length="53" mass="5947" checksum="BFE2D8F8F0680F6A" modified="2002-10-01" version="1">MASIYELDIRNQEISGITILSDRAEVKRRVPVNLKAGVSEICLKVVGKQQFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXG5</accession>
    <name>Q8MXG5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">grld-1</name>
        <name evidence="10" type="ORF">CELE_F29C4.7</name>
        <name evidence="12" type="ORF">F29C4.7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM Spen family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD62181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741284.1">
        <property type="nucleotide sequence ID" value="NM_171238.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXG5"/>
    <dbReference type="SMR" id="Q8MXG5"/>
    <dbReference type="PeptideAtlas" id="Q8MXG5"/>
    <dbReference type="GeneID" id="176827"/>
    <dbReference type="UCSC" id="F29C4.7a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017929"/>
    <dbReference type="CTD" id="176827"/>
    <dbReference type="WormBase" id="F29C4.7b">
        <property type="protein sequence ID" value="CE31493"/>
        <property type="gene ID" value="WBGene00017929"/>
        <property type="gene designation" value="grld-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10050565at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017929">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXG5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010912">
        <property type="entry name" value="SPOC_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50917">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="169"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="251"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="SPOC" evidence="9">
        <location>
            <begin position="365"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD62181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F29C4.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MXG5"/>
        </source>
    </evidence>
    <sequence length="423" mass="48406" checksum="1BE08B208ECA1AAB" modified="2002-10-01" version="1">MAEERGRPQYRPNCNGLSSYYRERFGSHSPEVYLNLRISGFDDRLEREQIKQYLTQELKKYAPFEIKVVKNPEEDERLAYVNFERNDCARKVRYTLMDRLKSVLGKRVQCDPAGILRDQEGKYIPDRFNRAQHGADSKREGGSGSGNRGRPTKEPSTWRLKQDDDEATRTLFVGNMPSDVKEREIRHVFEEHGKVEEVDIKTPINTDAAYAFVMFQTVDQAIQAKAEEQDRPIRAGGSRMKIGYGKSQVSRRLFVGGLGSWCDKEILQKAFGEFGFVENIDYDHGQPYAYVVYENTHTSQEACRSLRGACISKGNHPIMVDYAKDLTAQPEKQQFMRKRRASKSPVGASAVRTPPGSPKDVVRNFAELEEAYAATWSGKMALKKTDYPVKFYRVYGAERLPVKLLRDEDDVPLRLLITQSVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXG8</accession>
    <name>Q8MXG8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">inx-18</name>
        <name evidence="12" type="synonym">inx</name>
        <name evidence="15" type="ORF">C18H7.2</name>
        <name evidence="13" type="ORF">CELE_C18H7.2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD63290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741295.1">
        <property type="nucleotide sequence ID" value="NM_171247.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXG8"/>
    <dbReference type="SMR" id="Q8MXG8"/>
    <dbReference type="GeneID" id="182801"/>
    <dbReference type="UCSC" id="C18H7.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00002140"/>
    <dbReference type="CTD" id="182801"/>
    <dbReference type="WormBase" id="C18H7.2b">
        <property type="protein sequence ID" value="CE31309"/>
        <property type="gene ID" value="WBGene00002140"/>
        <property type="gene designation" value="inx-18"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035763_0_1_1"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002140">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXG8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF25">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD63290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="C18H7.2b"/>
        </source>
    </evidence>
    <sequence length="412" mass="47668" checksum="FE54BF40B5BAC083" modified="2002-10-01" version="1">MVGGFRIGMHFLASALRFLEPRVDDDFVDRLHYLYTSTMVLMFAVLVSAKQYVGHPIECFVPAQFTRAMEQYTENYCWVQNTYWVPFQDLIPHRLDDRERRQIGYYQWVPFVLAVAALTFHIPSSVWRMLAGQSGLNAGLVLQLVCGDENVDPVVRDKTVDIVARHIDDALMYQRDHGARRHSVYIFAIFKLGKFYGAYVSSVYIFIKALHLANVILQFMLLNSFLQTSDYPMFGAHVLYDLFMGREWRDSGKFPRVTLCDFEIRVLGNVHRHTVQCVLVINMLTEKIFIFLWLWLTVLAIVTALNLIFWFIALVSNSCREHFVSKHLDIQSDQISRFVHRFLRADGVFLLQMIASHSGNLMAAKVTEQLWMIFVRRSGKPVIEDKIEDRGSVRSTNGNDWESVGELSIVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXH5</accession>
    <name>Q8MXH5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">unc-77</name>
        <name evidence="27" type="ORF">C11D2.6</name>
        <name evidence="25" type="ORF">CELE_C11D2.6</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD64245.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T32962">
        <property type="entry name" value="T32962"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741414.2">
        <property type="nucleotide sequence ID" value="NM_171353.6"/>
    </dbReference>
    <dbReference type="SMR" id="Q8MXH5"/>
    <dbReference type="GeneID" id="177379"/>
    <dbReference type="UCSC" id="C11D2.6d">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006809"/>
    <dbReference type="CTD" id="177379"/>
    <dbReference type="WormBase" id="C11D2.6c">
        <property type="protein sequence ID" value="CE48978"/>
        <property type="gene ID" value="WBGene00006809"/>
        <property type="gene designation" value="unc-77"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006809">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXH5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032224">
        <property type="term" value="P:positive regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000089">
        <property type="entry name" value="Four domain-type voltage-gated ion channel alpha-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000080">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000060">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000061">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000066">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000030">
        <property type="entry name" value="sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000032">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000034">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF2">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="864"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="909"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="944"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1006"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1120"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1201"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1233"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1273"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1307"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1345"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1430"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="369"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="870"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="1199"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1633"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1642"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="1658"/>
            <end position="1668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CCD64245.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="C11D2.6c"/>
        </source>
    </evidence>
    <sequence length="1801" mass="208832" checksum="1E241F7AD10DF772" modified="2013-12-11" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1997-02-01" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q93547</accession>
    <name>Q93547_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine-protein kinase TOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">htt-1</name>
        <name evidence="1" type="ORF">CELE_F21G4.6</name>
        <name evidence="3" type="ORF">F21G4.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAB02662.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_077262.5"/>
    </dbReference>
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    <dbReference type="STRING" id="6239.F21G4.6.1"/>
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    <dbReference type="UCSC" id="F21G4.6">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="CTD" id="181204"/>
    <dbReference type="WormBase" id="F21G4.6a">
        <property type="protein sequence ID" value="CE42980"/>
        <property type="gene ID" value="WBGene00009027"/>
        <property type="gene designation" value="htt-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RT5G">
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        <property type="component" value="Chromosome X"/>
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        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
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        <property type="term" value="P:vesicle transport along microtubule"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="InterPro" id="IPR028426">
        <property type="entry name" value="Huntingtin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170:SF10">
        <property type="entry name" value="HUNTINGTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170">
        <property type="entry name" value="HUNTINGTON DISEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB02662.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F21G4.6a"/>
        </source>
    </evidence>
    <sequence length="2022" mass="232043" checksum="206D5D9A342B9CFF" modified="2008-11-04" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N3B7</accession>
    <name>Q9N3B7_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y54G2A.16</name>
        <name evidence="2 4" type="ORF">Y54G2A.16</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD83504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_500263.2">
        <property type="nucleotide sequence ID" value="NM_067862.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="177069"/>
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        <property type="organism name" value="c. elegans"/>
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    <dbReference type="CTD" id="177069"/>
    <dbReference type="WormBase" id="Y54G2A.16a">
        <property type="protein sequence ID" value="CE34412"/>
        <property type="gene ID" value="WBGene00021881"/>
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    <dbReference type="HOGENOM" id="CLU_099987_0_0_1"/>
    <dbReference type="OrthoDB" id="5811368at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021881">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N3B7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD83504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y54G2A.16a"/>
        </source>
    </evidence>
    <sequence length="167" mass="18490" checksum="95BC939E6AB60CC1" modified="2003-10-01" version="2">MARYRCCFGTCRLRVGACVIGIACILIAILSLCSLLSVSTAMTSDAQSFLTTPIVLSLLQFATSMIMIVAVLTSFHWLLLPFMLSCIANLLALVVLCSWGVLRRHELSNSVVPLLLIGSTGIGLLYLWFLTIISMTFVLIRDRKIMGYDDEFNIENRQFDRASSSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N3C5</accession>
    <name>Q9N3C5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="12">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">pign-1</name>
        <name evidence="14" type="ORF">CELE_Y54E10BR.1</name>
        <name evidence="16" type="ORF">Y54E10BR.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="12"/>
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        <property type="protein sequence ID" value="CCD72995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001262368.4"/>
    </dbReference>
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        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021840"/>
    <dbReference type="CTD" id="171881"/>
    <dbReference type="WormBase" id="Y54E10BR.1b">
        <property type="protein sequence ID" value="CE34410"/>
        <property type="gene ID" value="WBGene00021840"/>
        <property type="gene designation" value="pign-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007676_0_0_1"/>
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    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021840">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9N3C5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000088">
        <property type="entry name" value="Phosphatidylinositol glycan anchor biosynthesis, class N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol glycan anchor biosynthesis, class N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="13">
        <location>
            <begin position="403"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD72995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="Y54E10BR.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N3C5"/>
        </source>
    </evidence>
    <sequence length="906" mass="102548" checksum="7E3D3ED300333CAF" modified="2012-01-25" version="5"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N3I1</accession>
    <name>Q9N3I1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y51H7C.13</name>
        <name evidence="3 5" type="ORF">Y51H7C.13</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD71799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_493976.2">
        <property type="nucleotide sequence ID" value="NM_061575.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N3I1"/>
    <dbReference type="SMR" id="Q9N3I1"/>
    <dbReference type="STRING" id="6239.Y51H7C.13.1"/>
    <dbReference type="PaxDb" id="6239-Y51H7C.13"/>
    <dbReference type="PeptideAtlas" id="Q9N3I1"/>
    <dbReference type="GeneID" id="190180"/>
    <dbReference type="UCSC" id="Y51H7C.13">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021791"/>
    <dbReference type="CTD" id="190180"/>
    <dbReference type="WormBase" id="Y51H7C.13a">
        <property type="protein sequence ID" value="CE36040"/>
        <property type="gene ID" value="WBGene00021791"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QS87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_807070_0_0_1"/>
    <dbReference type="OMA" id="VCRLCCI"/>
    <dbReference type="OrthoDB" id="5877900at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021791">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331550" evidence="2">
        <location>
            <begin position="18"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD71799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y51H7C.13a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q9N3I1"/>
        </source>
    </evidence>
    <sequence length="344" mass="36095" checksum="FC05E523F4A9EA6D" modified="2004-03-01" version="2">MLHNSFLLSVLIGCSLASFIAPHYVGYGYYQTGPQNPDGSGVNPPGVSPNFGTGTGTIDGNGNGNGITGTTARPIRIVRVGPNGRLIVTNCSVCRLCCVGRNISYRIEDGTTAVVPPAVSGTSPPAPVDQKPPPCIPPTTTTTTTTTTRPPCPYPPATNTPPAPEPTLPYEYTTQPPATWPPVENTTPEQPTVPTPGPSRECCYIDLRTLQATVSCGVAIGTKCCHQSCSGTSQRQITLNYDIIARLFPNLPSQIQCSEAVRLGLVQSTEIQGVCTRYEPYPVPTENPPSPTNYPPEVTTGSPGGEVEIPTNGPVDAYVVQTTTSSAPILASLLTFVVATVLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>U4PDZ2</accession>
    <name>U4PDZ2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_T26C12.3</name>
        <name evidence="3 5" type="ORF">T26C12.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH92974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PDZ2"/>
    <dbReference type="SMR" id="U4PDZ2"/>
    <dbReference type="AGR" id="WB:WBGene00020833"/>
    <dbReference type="WormBase" id="T26C12.3b">
        <property type="protein sequence ID" value="CE48905"/>
        <property type="gene ID" value="WBGene00020833"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068965_0_0_1"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020833">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PDZ2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003797">
        <property type="entry name" value="Protein CBG01632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDH92974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T26C12.3b"/>
        </source>
    </evidence>
    <sequence length="238" mass="26662" checksum="AF560AB8DDF2A501" modified="2013-12-11" version="1">MGISQRVPSTLPGSNGIVMYRTPRCPVCSAPPSRSPPVPNLALDHLLRNMRTFRWNQIEKDVSSRGSRKWDDGPIQDCRIAVLGSSKVGKTCFTMVQNGNEVMFPDVHSENEDADAYMVEIADGMSIERSCVASNGIIIMYSVVDRQSFYHAAEIFKRLEHSREHNQPIVLVGSKKDMRVKRVVTSFEGQQLARTLGIPFLEVSSKQNDCVFEAFEELVSLIQKQNAAFKNVVKQSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4PDZ7</accession>
    <name>U4PDZ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">srv-4</name>
        <name evidence="6" type="ORF">CELE_F15E6.7</name>
        <name evidence="8" type="ORF">F15E6.7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH92979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294282.1">
        <property type="nucleotide sequence ID" value="NM_001307353.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PDZ7"/>
    <dbReference type="SMR" id="U4PDZ7"/>
    <dbReference type="GeneID" id="184535"/>
    <dbReference type="KEGG" id="cel:CELE_F15E6.7"/>
    <dbReference type="AGR" id="WB:WBGene00005715"/>
    <dbReference type="CTD" id="184535"/>
    <dbReference type="WormBase" id="F15E6.7b">
        <property type="protein sequence ID" value="CE48514"/>
        <property type="gene ID" value="WBGene00005715"/>
        <property type="gene designation" value="srv-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1185958_0_0_1"/>
    <dbReference type="OrthoDB" id="5838958at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005715">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PDZ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627:SF14">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH92979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F15E6.7b"/>
        </source>
    </evidence>
    <sequence length="234" mass="27510" checksum="E4749924042CD4E5" modified="2013-12-11" version="1">MPLSINLSLLPISHLIFIPICWFSVFLYLRVLYIIHQLRKNVFKSSFFLIIRMHAITDLLMFLYVELVARPRKYRVHNLFEAANDHWIPQLLWFSLTVIKNAMFLGYTVVAVNRCSEIFRFRNHVKFWSPTLILIVYLSEWLAPTIVLIPLFYTGNHNFSLIAAPSGGLFLRASPEFIKMCSRTSLYRYFASWSAHFCISSLLCIWCRLCRKLCQTHSSVLIDRNLQISTHQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>W6RRZ0</accession>
    <name>W6RRZ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myosin VI cargo binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">spe-15</name>
        <name evidence="3" type="ORF">CELE_F47G6.4</name>
        <name evidence="5" type="ORF">F47G6.4</name>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C06A8.8c"/>
        </source>
    </evidence>
    <sequence length="168" mass="19215" checksum="1AF64D404A422E3D" modified="2018-12-05" version="1">MSIFSRFLSFFYSVKAKIVSKMESENRKFIGVFELLDHLKESENERRKSEILPFDSHLKDEPKQTEMSYIELDKGILLPLKSKPKMRETKTIVGLYDTDSEDEEILFSKEMLNRLRKREAVMKNPQLPTTSAITETIAIDTSCEKSAPVSSSSSSKQQSSVSPPLSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1E4T2</accession>
    <name>A0A3B1E4T2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Globin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">glb-9</name>
        <name evidence="9" type="ORF">C28F5.2</name>
        <name evidence="7" type="ORF">CELE_C28F5.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="VAY52122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355412.1">
        <property type="nucleotide sequence ID" value="NM_001368598.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1E4T2"/>
    <dbReference type="SMR" id="A0A3B1E4T2"/>
    <dbReference type="GeneID" id="182985"/>
    <dbReference type="AGR" id="WB:WBGene00016184"/>
    <dbReference type="CTD" id="182985"/>
    <dbReference type="WormBase" id="C28F5.2e">
        <property type="protein sequence ID" value="CE52761"/>
        <property type="gene ID" value="WBGene00016184"/>
        <property type="gene designation" value="glb-9"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5848155at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016184">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1E4T2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF11">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="6">
        <location>
            <begin position="52"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VAY52122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C28F5.2e"/>
        </source>
    </evidence>
    <sequence length="261" mass="29907" checksum="11D1EBF29592A8F0" modified="2018-12-05" version="1">MDELSTSPYQFRRTQSCRVTNKGPNGLARRGTQRGCSRSKSTRRGNLGTIASLTFSQKQALNLSWRLLKPQASACFRKIFLELEIASPKVKQIFYKAALVDAFNKDDDNSATMEVHIKLTTKFFDELLVSLDDETEFVNKIRGIGSAHAILAKGSNFSSDIWERLGEIAMERVCSHEVVTKTREASRAWRTLIAILIDELRGGFEGELRQHRSQSQKRMMFMRRKSSSTDQIEMGKMEDEEELHAKLQQLRMDYNQTLPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1E520</accession>
    <name>A0A3B1E520_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mec-2</name>
        <name evidence="7" type="ORF">CELE_F14D12.4</name>
        <name evidence="9" type="ORF">F14D12.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368716.1">
        <property type="nucleotide sequence ID" value="NM_001380975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1E520"/>
    <dbReference type="SMR" id="A0A3B1E520"/>
    <dbReference type="GeneID" id="180826"/>
    <dbReference type="AGR" id="WB:WBGene00003166"/>
    <dbReference type="CTD" id="180826"/>
    <dbReference type="WormBase" id="F14D12.4o">
        <property type="protein sequence ID" value="CE52722"/>
        <property type="gene ID" value="WBGene00003166"/>
        <property type="gene designation" value="mec-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003166">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1E520">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03403">
        <property type="entry name" value="SPFH_stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="72"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VAY52618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F14D12.4o"/>
        </source>
    </evidence>
    <sequence length="432" mass="47386" checksum="C2936B746C8E3B45" modified="2018-12-05" version="1">MYDDPAERKFSVPPPREFKFSPYIPRIHTDVKRPPTEPLGANIQNEFGVCGWILTILSYLLIFFTLPISACMCIKVVQEYERAVIFRLGRLMPGGAKGPGIFFIVPCIDTYRKVDLRVLSFEVPPQEILSKDSVTVAVDAVVYFRISNATISVTNVEDAARSTKLLAQTTLRNILGTKTLAEMLSDREAISHQMQTTLDEATEPWGVKVERVEVKDVRLPVQLQRAMAAEAEAAREARAKVIVAEGEQKASRALKEAAEVIAESPSALQLRYLQTLNSISAEKNSTIIFPFPIDLLSAFLQRTPPKVEEPPSLPKKIRSCCLYKYPDWVQGMVGSEGGGGHGHSHGGGGGGLGSSQVRAKGSIPSISSRFRPEHHNHQWPSAAPQHARSAVSLRSTADLSSKSVPNISESVGPRFTVWSTIASKQQTGRCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1E532</accession>
    <name>A0A3B1E532_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mec-2</name>
        <name evidence="7" type="ORF">CELE_F14D12.4</name>
        <name evidence="9" type="ORF">F14D12.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355458.1">
        <property type="nucleotide sequence ID" value="NM_001368508.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1E532"/>
    <dbReference type="SMR" id="A0A3B1E532"/>
    <dbReference type="GeneID" id="180826"/>
    <dbReference type="AGR" id="WB:WBGene00003166"/>
    <dbReference type="CTD" id="180826"/>
    <dbReference type="WormBase" id="F14D12.4k">
        <property type="protein sequence ID" value="CE52760"/>
        <property type="gene ID" value="WBGene00003166"/>
        <property type="gene designation" value="mec-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003166">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1E532">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03403">
        <property type="entry name" value="SPFH_stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="80"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VAY52585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F14D12.4k"/>
        </source>
    </evidence>
    <sequence length="333" mass="36824" checksum="FD1358B88D28BBD5" modified="2018-12-05" version="1">MSRKRSIRERMAEMADSRRNPKKPTPPSIFEAAQLIGKFSGQRIDLLSANIQNEFGVCGWILTILSYLLIFFTLPISACMCIKVVQEYERAVIFRLGRLMPGGAKGPGIFFIVPCIDTYRKVDLRVLSFEVPPQEILSKDSVTVAVDAVVYFRISNATISVTNVEDAARSTKLLAQTTLRNILGTKTLAEMLSDREAISHQMQTTLDEATEPWGVKVERVEVKDVRLPVQLQRAMAAEAEAAREARAKVIVAEGEQKASRALKEAAEVIAESPSALQLRYLQTLNSISAEKNSTIIFPFPIDLLSAFLQRTPPKVDNNFAFPTHKAGGIPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3B1E553</accession>
    <name>A0A3B1E553_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mec-2</name>
        <name evidence="7" type="ORF">CELE_F14D12.4</name>
        <name evidence="9" type="ORF">F14D12.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VAY52614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355478.1">
        <property type="nucleotide sequence ID" value="NM_001368511.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3B1E553"/>
    <dbReference type="SMR" id="A0A3B1E553"/>
    <dbReference type="GeneID" id="180826"/>
    <dbReference type="AGR" id="WB:WBGene00003166"/>
    <dbReference type="CTD" id="180826"/>
    <dbReference type="WormBase" id="F14D12.4i">
        <property type="protein sequence ID" value="CE52720"/>
        <property type="gene ID" value="WBGene00003166"/>
        <property type="gene designation" value="mec-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003166">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3B1E553">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03403">
        <property type="entry name" value="SPFH_stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="72"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VAY52614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F14D12.4i"/>
        </source>
    </evidence>
    <sequence length="414" mass="45123" checksum="D5158BF076797ABE" modified="2018-12-05" version="1">MYDDPAERKFSVPPPREFKFSPYIPRIHTDVKRPPTEPLGANIQNEFGVCGWILTILSYLLIFFTLPISACMCIKVVQEYERAVIFRLGRLMPGGAKGPGIFFIVPCIDTYRKVDLRVLSFEVPPQEILSKDSVTVAVDAVVYFRISNATISVTNVEDAARSTKLLAQTTLRNILGTKTLAEMLSDREAISHQMQTTLDEATEPWGVKVERVEVKDVRLPVQLQRAMAAEAEAAREARAKVIVAEGEQKASRALKEAAEVIAESPSALQLRYLQTLNSISAEKNSTIIFPFPIDLLSAFLQRTPPKVEEPPSLPKKIRSCCLYKYPDWVQGMVGSEGGGGHGHSHGGGGGGLGSSQGAFHPSQAGSGPSTTTTSGRPLLRSMREAQFHSAAPPISAPNQSQTSVSQLDPALLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P6NNU2</accession>
    <name>A0A3P6NNU2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein TAPT1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_F26F2.7</name>
        <name evidence="8 10" type="ORF">F26F2.7</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="VDJ65107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P6NNU2"/>
    <dbReference type="SMR" id="A0A3P6NNU2"/>
    <dbReference type="AGR" id="WB:WBGene00009172"/>
    <dbReference type="WormBase" id="F26F2.7c">
        <property type="protein sequence ID" value="CE52948"/>
        <property type="gene ID" value="WBGene00009172"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3P6NNU2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDJ65107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F26F2.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A3P6NNU2"/>
        </source>
    </evidence>
    <sequence length="504" mass="57106" checksum="21CF03A070B42DE1" modified="2019-02-13" version="1">MSIFGALLRIKRWTSAETCDFLKVVIIVAASMLIREIDSSFLYHQVRSQGVIKLYIFYNMLEVADRLFSSLGQDIFDALLWTANSEKRFSVGYFIRTCGHLIVAILYATLHSFLVILQATTLNVAFNSHNQTVLAIMMSNNFVELKGSVFKKFAKANLFQMACSDVRERFHIFALLFVVMIRNMTAVNWNIDSFTEMIPDIIMVVGCEYFVDWLKHAFITKFNEINAEVYKDFTITIAFDVIRSRDQSAFSDYSDQVSRRMGFIPIPLSIMIIRVLSQTFTLDNWGSCIIFGIGWLLVFAVKICNGVVMLGQACHHVKRFRDIQARAEFELFRKRMVEKKSKSAPNSPRMSLIDFTDVLHQPAAGKGFTVSDMLSQWEELQPSLLSSEIRRSTDRETAVSHLTARSDERTPRRAVSMAHIPRRDRSEPPPAPSMDQDPQLDTEDPVVTENNTNSNSEQASPVKKKTTAAPVTSSASTNTNATSSDELADVTAYKMPEQGVQRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P6NNV9</accession>
    <name>A0A3P6NNV9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SANT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">swsn-1</name>
        <name evidence="11" type="ORF">CELE_Y113G7B.23</name>
        <name evidence="13" type="ORF">Y113G7B.23</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMARCC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="VDJ65117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368722.1">
        <property type="nucleotide sequence ID" value="NM_001380878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P6NNV9"/>
    <dbReference type="SMR" id="A0A3P6NNV9"/>
    <dbReference type="GeneID" id="180324"/>
    <dbReference type="AGR" id="WB:WBGene00004203"/>
    <dbReference type="CTD" id="180324"/>
    <dbReference type="WormBase" id="Y113G7B.23d">
        <property type="protein sequence ID" value="CE52890"/>
        <property type="gene ID" value="WBGene00004203"/>
        <property type="gene designation" value="swsn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3P6NNV9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032448">
        <property type="entry name" value="SWIRM-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16498">
        <property type="entry name" value="SWIRM-assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDJ65117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="688" mass="74301" checksum="D3958460656788DD" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P6PCZ1</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="2">
        <location>
            <begin position="300"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDJ66188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F46G11.1b"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A3P6PCZ1"/>
        </source>
    </evidence>
    <sequence length="568" mass="65595" checksum="31EBFE4E713C7BC7" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5S9MRT4</accession>
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        <submittedName>
            <fullName evidence="2">Citrate-sodium symporter</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">CELE_F02E11.7</name>
        <name evidence="2 4" type="ORF">F02E11.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A5S9MRT4"/>
    <dbReference type="AGR" id="WB:WBGene00195073"/>
    <dbReference type="WormBase" id="F02E11.7d">
        <property type="protein sequence ID" value="CE54022"/>
        <property type="gene ID" value="WBGene00195073"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5773905at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A5S9MRT4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035161">
        <property type="entry name" value="DUF5332"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38612:SF2">
        <property type="entry name" value="PROTEIN DCT-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38612">
        <property type="entry name" value="PROTEIN DCT-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA0059149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F02E11.7d"/>
        </source>
    </evidence>
    <sequence length="69" mass="8012" checksum="427F3F25DABF6CC8" modified="2020-04-22" version="1">MSGSGEKMIMTRKITLGTDQDPYNKEELVNTLKGRELGFFVIFYIFAVMCIVMAFEFFKPIIFTDNYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7R9XLP7</accession>
    <name>A0A7R9XLP7_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">Nanos-type domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4 6" type="primary">nos-3</name>
        <name evidence="4" type="ORF">CELE_Y53C12B.3</name>
        <name evidence="6" type="ORF">Y53C12B.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nanos family.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001393164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7R9XLP7"/>
    <dbReference type="SMR" id="A0A7R9XLP7"/>
    <dbReference type="GeneID" id="174535"/>
    <dbReference type="KEGG" id="cel:CELE_Y53C12B.3"/>
    <dbReference type="AGR" id="WB:WBGene00003785"/>
    <dbReference type="CTD" id="174535"/>
    <dbReference type="WormBase" id="Y53C12B.3d">
        <property type="protein sequence ID" value="CE54289"/>
        <property type="gene ID" value="WBGene00003785"/>
        <property type="gene designation" value="nos-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870823at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Nanos, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038129">
        <property type="entry name" value="Nanos_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024161">
        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05741">
        <property type="entry name" value="zf-nanos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
        <property type="entry name" value="ZF_NANOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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            <begin position="714"/>
            <end position="768"/>
        </location>
    </feature>
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            <begin position="24"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="616"/>
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    </feature>
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            <end position="33"/>
        </location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="790"/>
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        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD8118735.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y53C12B.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A7R9XLP7"/>
        </source>
    </evidence>
    <sequence length="886" mass="97898" checksum="3F5FB2F2BDAAC693" modified="2021-06-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I7W4</accession>
    <name>A0A8D9I7W4_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Activated in Blocked Unfolded protein response</fullName>
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        <name evidence="2" type="ORF">CELE_M195.2</name>
        <name evidence="2 4" type="ORF">M195.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAG8860235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9I7W4"/>
    <dbReference type="AGR" id="WB:WBGene00010948"/>
    <dbReference type="WormBase" id="M195.2d">
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        <property type="gene ID" value="WBGene00010948"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5849845at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33750:SF3">
        <property type="entry name" value="ACTIVATED IN BLOCKED UNFOLDED PROTEIN RESPONSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33750">
        <property type="entry name" value="PROTEIN CBG02727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG8860235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="M195.2d"/>
        </source>
    </evidence>
    <sequence length="256" mass="26724" checksum="8B4E4B5DD2D10CE6" modified="2022-01-19" version="1">MSTCSDTCRSSCSNRVSQSTCDATCQNTCSSMCPSQSPQGSPQLPTQTTTTNAPIKIKIQVQQQQPQQSPQNSPQQQAQPQASQPIAQTTQTIPASIPQAAPQQQPNCMAQCQTGCANSCAQLSPQPTEGCPTNCRNTCNEVCAPTVASQPSTQAPQSYPVLLDPQQRCSSECQSVCQLACVTQKSAPPSSCLDKCSPQCDSACTSPQVQRNSAQLFTPSADQAPASSAQPIKINISLAPLKPSASTSSSPSPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4QFA8</accession>
    <name>A0A8S4QFA8_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">NR LBD domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">CELE_Y39E4B.10</name>
        <name evidence="1 3" type="ORF">Y39E4B.10</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A8S4QFA8"/>
    <dbReference type="AGR" id="WB:WBGene00012719"/>
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        <property type="gene ID" value="WBGene00012719"/>
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    <dbReference type="OrthoDB" id="5839964at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH2176115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y39E4B.10c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4QFA8"/>
        </source>
    </evidence>
    <sequence length="262" mass="30543" checksum="EA3EAE97516C235C" modified="2022-10-12" version="1">MRALMWDVLSSMTKLGGIAWFNIDKTFAKMAIQMNHVEMQMSLHDPQNLDVLQFCRHLRILELYTNAICDSEMFGEDGMEVIPHTVGDSTKFILLFWVEAYLQKIQIPTQMSLSIFNFAVFLFCHEELAITEEKVRKHIGEVMLDTAFTVLEEASESDLRGEVGQLFSDILERLAELEVLNERVPLFLMKYLDKIRCAEDYEGWKGRVIDCKCCIMDLRGRVDWYSVKTLKESRQLLPKFTDPEQHELGQLFTIFDKLPRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4QFB7</accession>
    <name>A0A8S4QFB7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GHMP kinase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mvk-1</name>
        <name evidence="7" type="ORF">CELE_Y42G9A.4</name>
        <name evidence="9" type="ORF">Y42G9A.4</name>
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    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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</entry>
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        <property type="component" value="Chromosome III"/>
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            <dbReference type="EMBL" id="CBB16282.1"/>
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    </evidence>
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        <source>
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</entry>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="2">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBW48397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F54C8.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="E1B6R4"/>
        </source>
    </evidence>
    <sequence length="223" mass="25062" checksum="6E19751F952E615C" modified="2010-11-02" version="1">MGKIDKTVDPEFEAQCEVLKDIHRRYGLVVAAAKNFSHVLTQMAEAEKKLSESFYQLSMKEEQIKAQCTMTSETMRGVGEQAASLDACLRYFISSMETVYNQTITDTLHTIYNTESARIEYDVDRNDISAATNPPQGQLTKNLPVGATEKCEEKKAKYEKLKNDAKIKMRLLEENRISVVAAQLEKLQSALAAYYSGNAKLLEASVRELSFLQSPQPSFIPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6R5</accession>
    <name>E1B6R5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F54C8.7</name>
        <name evidence="3 5" type="ORF">F54C8.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CBW48398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6R5"/>
    <dbReference type="SMR" id="E1B6R5"/>
    <dbReference type="PeptideAtlas" id="E1B6R5"/>
    <dbReference type="AGR" id="WB:WBGene00010040"/>
    <dbReference type="WormBase" id="F54C8.7f">
        <property type="protein sequence ID" value="CE45308"/>
        <property type="gene ID" value="WBGene00010040"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047975_1_0_1"/>
    <dbReference type="OrthoDB" id="9994780at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010040">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6R5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000085">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF5">
        <property type="entry name" value="ARFAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBW48398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F54C8.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="E1B6R5"/>
        </source>
    </evidence>
    <sequence length="154" mass="17188" checksum="C53F5AA056E2CA55" modified="2010-11-02" version="1">MTSETMRGVGEQAASLDACLRYFISSMETVYNQTITDTLHTIYNTESARIEYDVDRNDISAATNPPQGQLTKNLPVGATEKCEEKKAKYEKLKNDAKIKMRLLEENRISVVAAQLEKLQSALAAYYSGNAKLLEASVRELSFLQSPQPSFIPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>E1B6S0</accession>
    <name>E1B6S0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Equilibrative Nucleoside Transporter (ENT) Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ent-7</name>
        <name evidence="10" type="synonym">ent-4</name>
        <name evidence="8" type="ORF">CELE_F44D12.9</name>
        <name evidence="10" type="ORF">F44D12.9</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBW48389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255452.1">
        <property type="nucleotide sequence ID" value="NM_001268523.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1B6S0"/>
    <dbReference type="SMR" id="E1B6S0"/>
    <dbReference type="GeneID" id="177862"/>
    <dbReference type="KEGG" id="cel:CELE_F44D12.9"/>
    <dbReference type="AGR" id="WB:WBGene00009686"/>
    <dbReference type="CTD" id="177862"/>
    <dbReference type="WormBase" id="F44D12.9b">
        <property type="protein sequence ID" value="CE45325"/>
        <property type="gene ID" value="WBGene00009686"/>
        <property type="gene designation" value="ent-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021611_0_1_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009686">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1B6S0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF28">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER (ENT) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBW48389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F44D12.9b"/>
        </source>
    </evidence>
    <sequence length="161" mass="18275" checksum="15D119AFA1A21345" modified="2010-11-02" version="1">MMTDSVYSDPTNGITSVFGDSLFFPITTFLNFNLFAWIGSSLANYVQFPSEKYLWIGVALRTVFIPFYLFCNYRPDTRRWPVWFKNEWWFTIGCTIMAFTCGYMSSLALIYTPSKVPARYQKLSGMLASIFLMLGILIGVASTPIAAWAVDSIGSRKNMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>G4S9F5</accession>
    <name>G4S9F5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">I/LWEQ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tln-1</name>
        <name evidence="6" type="ORF">CELE_Y71G12B.11</name>
        <name evidence="8" type="ORF">Y71G12B.11</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD67997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001249039.1">
        <property type="nucleotide sequence ID" value="NM_001262110.3"/>
    </dbReference>
    <dbReference type="SMR" id="G4S9F5"/>
    <dbReference type="PeptideAtlas" id="G4S9F5"/>
    <dbReference type="GeneID" id="171736"/>
    <dbReference type="KEGG" id="cel:CELE_Y71G12B.11"/>
    <dbReference type="AGR" id="WB:WBGene00006771"/>
    <dbReference type="CTD" id="171736"/>
    <dbReference type="WormBase" id="Y71G12B.11c">
        <property type="protein sequence ID" value="CE46470"/>
        <property type="gene ID" value="WBGene00006771"/>
        <property type="gene designation" value="tln-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000364_1_0_1"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006771">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G4S9F5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000040">
        <property type="entry name" value="TaLiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.10:FF:000017">
        <property type="entry name" value="Talin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000001">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054082">
        <property type="entry name" value="Talin_IBS2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049108">
        <property type="entry name" value="Talin_R4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054060">
        <property type="entry name" value="TLN1-like_RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015009">
        <property type="entry name" value="Vinculin-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21896">
        <property type="entry name" value="Talin_IBS2B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21692">
        <property type="entry name" value="Talin_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21865">
        <property type="entry name" value="TLN1-like_RS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08913">
        <property type="entry name" value="VBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="I/LWEQ" evidence="5">
        <location>
            <begin position="1648"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1854"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD67997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y71G12B.11c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="G4S9F5"/>
        </source>
    </evidence>
    <sequence length="1890" mass="204646" checksum="2AE3A1453ACA223D" modified="2012-01-25" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-05-23" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform b of Ubiquilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ubql-1</name>
        <name evidence="3" type="ORF">F15C11.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2009" name="J. Cell Biol." volume="187" first="201" last="217">
            <title>Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD.</title>
            <authorList>
                <person name="Lim P.J."/>
                <person name="Danner R."/>
                <person name="Liang J."/>
                <person name="Doong H."/>
                <person name="Harman C."/>
                <person name="Srinivasan D."/>
                <person name="Rothenberg C."/>
                <person name="Wang H."/>
                <person name="Ye Y."/>
                <person name="Fang S."/>
                <person name="Monteiro M.J."/>
            </authorList>
            <dbReference type="PubMed" id="19822669"/>
            <dbReference type="DOI" id="10.1083/jcb.200903024"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2018" name="Proc. Natl. Acad. Sci. U.S.A." volume="115" first="E4199" last="E4208">
            <title>Nuclear export of ubiquitinated proteins via the UBIN-POST system.</title>
            <authorList>
                <person name="Hirayama S."/>
                <person name="Sugihara M."/>
                <person name="Morito D."/>
                <person name="Iemura S.I."/>
                <person name="Natsume T."/>
                <person name="Murata S."/>
                <person name="Nagata K."/>
            </authorList>
            <dbReference type="PubMed" id="29666234"/>
            <dbReference type="DOI" id="10.1073/pnas.1711017115"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2019" name="Cell" volume="0" first="0" last="0">
            <title>UBQLN4 represses homologous recombination and is overexpressed in aggressive tumors.</title>
            <authorList>
                <person name="Jachimowicz R.D."/>
                <person name="Beleggia F."/>
                <person name="Isensee J."/>
                <person name="Velpula B.B."/>
                <person name="Goergens J."/>
                <person name="Bustos M.A."/>
                <person name="Doll M.A."/>
                <person name="Shenoy A."/>
                <person name="Checa-Rodriguez C."/>
                <person name="Wiederstein J.L."/>
                <person name="Baranes-Bachar K."/>
                <person name="Bartenhagen C."/>
                <person name="Hertwig F."/>
                <person name="Teper N."/>
                <person name="Nishi T."/>
                <person name="Schmitt A."/>
                <person name="Distelmaier F."/>
                <person name="Luedecke H.J."/>
                <person name="Albrecht B."/>
                <person name="Krueger M."/>
                <person name="Schumacher B."/>
                <person name="Geiger T."/>
                <person name="Hoon D.S.B."/>
                <person name="Huertas P."/>
                <person name="Fischer M."/>
                <person name="Hucho T."/>
                <person name="Peifer M."/>
                <person name="Ziv Y."/>
                <person name="Reinhardt H.C."/>
                <person name="Wieczorek D."/>
                <person name="Shiloh Y."/>
            </authorList>
            <dbReference type="PubMed" id="30612738"/>
            <dbReference type="DOI" id="10.1016/j.cell.2018.11.024"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EFF7-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_059588"/>
        </isoform>
        <isoform>
            <id>G5EFF7-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EFF7-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_059589 VSP_059590"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_740884.1">
        <property type="nucleotide sequence ID" value="NM_171839.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F15C11.2b">
        <property type="protein sequence ID" value="CE31479"/>
        <property type="gene ID" value="WBGene00008852"/>
        <property type="gene designation" value="ubql-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F15C11.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F15C11.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F15C11.2c"/>
        </source>
    </evidence>
    <sequence length="484" mass="52278" checksum="2557845731C13A99" modified="2011-12-14" version="1">MATESALIKVHVKSPSNKYDVEIAADASVSELKDKVLVFVPTANKEQVCIIYTGKILKDEETLTQHKIADGHTVHLVIRNQARPTPAPAAATPTASSAPTMGGMGSPADILNNPDAMRSVMDNPITQQLLGNPEFMRTIIQSNPQFQALIERNPEVGHILNDPNVMRQTMEMIRNPNMFQEMMRNHDQAIRNLQGIPGGEAALERLYNDVQEPLLNSATNSLSGNPFASLRGDQSSEPRVDRAGQENNEALPNPWASNANQATNNQSNNRSADFNSLLDSPGISSLMEQMMSNPSMQASMFSPEVINSIRQNMSNNPGLIDSIVGQIPSARDNPQISEGIRRSFPQMLNMMSDPSVMEAMRNPRVSEAFRQIQEGFSTLRREAPQLLNLFQAGAMGGGAFGSDANASSAGANSANGLADLFNSMNMGGGRPSSTAAPVNPEQTYASQLEQLQSMGFSDRARNVAALTATFGDLNAAVERLLNSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-05-23" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>G5EFF7-3</accession>
    <name>UBQL_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform c of Ubiquilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ubql-1</name>
        <name evidence="3" type="ORF">F15C11.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2009" name="J. Cell Biol." volume="187" first="201" last="217">
            <title>Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD.</title>
            <authorList>
                <person name="Lim P.J."/>
                <person name="Danner R."/>
                <person name="Liang J."/>
                <person name="Doong H."/>
                <person name="Harman C."/>
                <person name="Srinivasan D."/>
                <person name="Rothenberg C."/>
                <person name="Wang H."/>
                <person name="Ye Y."/>
                <person name="Fang S."/>
                <person name="Monteiro M.J."/>
            </authorList>
            <dbReference type="PubMed" id="19822669"/>
            <dbReference type="DOI" id="10.1083/jcb.200903024"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2018" name="Proc. Natl. Acad. Sci. U.S.A." volume="115" first="E4199" last="E4208">
            <title>Nuclear export of ubiquitinated proteins via the UBIN-POST system.</title>
            <authorList>
                <person name="Hirayama S."/>
                <person name="Sugihara M."/>
                <person name="Morito D."/>
                <person name="Iemura S.I."/>
                <person name="Natsume T."/>
                <person name="Murata S."/>
                <person name="Nagata K."/>
            </authorList>
            <dbReference type="PubMed" id="29666234"/>
            <dbReference type="DOI" id="10.1073/pnas.1711017115"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2019" name="Cell" volume="0" first="0" last="0">
            <title>UBQLN4 represses homologous recombination and is overexpressed in aggressive tumors.</title>
            <authorList>
                <person name="Jachimowicz R.D."/>
                <person name="Beleggia F."/>
                <person name="Isensee J."/>
                <person name="Velpula B.B."/>
                <person name="Goergens J."/>
                <person name="Bustos M.A."/>
                <person name="Doll M.A."/>
                <person name="Shenoy A."/>
                <person name="Checa-Rodriguez C."/>
                <person name="Wiederstein J.L."/>
                <person name="Baranes-Bachar K."/>
                <person name="Bartenhagen C."/>
                <person name="Hertwig F."/>
                <person name="Teper N."/>
                <person name="Nishi T."/>
                <person name="Schmitt A."/>
                <person name="Distelmaier F."/>
                <person name="Luedecke H.J."/>
                <person name="Albrecht B."/>
                <person name="Krueger M."/>
                <person name="Schumacher B."/>
                <person name="Geiger T."/>
                <person name="Hoon D.S.B."/>
                <person name="Huertas P."/>
                <person name="Fischer M."/>
                <person name="Hucho T."/>
                <person name="Peifer M."/>
                <person name="Ziv Y."/>
                <person name="Reinhardt H.C."/>
                <person name="Wieczorek D."/>
                <person name="Shiloh Y."/>
            </authorList>
            <dbReference type="PubMed" id="30612738"/>
            <dbReference type="DOI" id="10.1016/j.cell.2018.11.024"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EFF7-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EFF7-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_059590 VSP_059589"/>
        </isoform>
        <isoform>
            <id>G5EFF7-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_059588"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_740885.1">
        <property type="nucleotide sequence ID" value="NM_170895.6"/>
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    <dbReference type="WormBase" id="F15C11.2c">
        <property type="protein sequence ID" value="CE31480"/>
        <property type="gene ID" value="WBGene00008852"/>
        <property type="gene designation" value="ubql-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F15C11.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F15C11.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F15C11.2c"/>
        </source>
    </evidence>
    <sequence length="454" mass="49037" checksum="DF5B5BB55E933484" modified="2011-12-14" version="1">MATESALIKVHVKSPSNKYDVEIAADASVSELKDKVLVFVPTANKEQVCIIYTGKILKDEETLTQHKIADGHTVHLVIRNQARPTPAPAAATPTASSAPSSNPTPSSQPNPTNNPFAAMGGMGSPADILNNPDAMRSVMDNPITQQLLGNPEFMRTIIQSNPQFQALIERNPEVGHILNDPNVMRQTMEMIRNPNMFQEMMRNHDQAIRNLQGIPGGEAALERLYNDVQEPLLNSATNSLSGNPFASLRGDQSSEPRVDRAGQENNEALPNPWASNANQATNNQSNNRSADFNSLLDSPGISSLMEQMMSNPSMQASMFSPEVINSIRQNMSNNPGLIDSIVGQIPSARDNPQISEGIRRSFPQMLNMMSDPSVMEAMRNPRVSEAFRQIQEGFSTLRREAPQLLNLFQAGAMGGGAFGSDANASSAGANSANGLADLFNSMNMGGGRVSILNI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-10-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G5EG14-2</accession>
    <name>CATIN_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cacn-1</name>
        <name type="ORF">W03H9.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Dev. Biol." volume="341" first="176" last="185">
            <title>CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans.</title>
            <authorList>
                <person name="Tannoury H."/>
                <person name="Rodriguez V."/>
                <person name="Kovacevic I."/>
                <person name="Ibourk M."/>
                <person name="Lee M."/>
                <person name="Cram E.J."/>
            </authorList>
            <dbReference type="PubMed" id="20188721"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.02.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EG14-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_044144"/>
        </isoform>
        <isoform>
            <id>G5EG14-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_044143"/>
        </isoform>
        <isoform>
            <id>G5EG14-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001254420.1">
        <property type="nucleotide sequence ID" value="NM_001267491.3"/>
    </dbReference>
    <dbReference type="WormBase" id="W03H9.4b">
        <property type="protein sequence ID" value="CE46257"/>
        <property type="gene ID" value="WBGene00012230"/>
        <property type="gene designation" value="cacn-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="345" mass="40449" checksum="1845FA431495EC9A" modified="2011-12-14" version="1">MDAKIRGNSGNKGYWQDLDDQLKVFIARKRLREHHGRVLRLQLAIIKEEQKKEIQQQESEELLPVAEVPPQVKIQKEEEEEEEEDEDDEKISKKVRRKIDVQTLDDPELDEPERERKWRALTGDQLDDVTRELYRIGCYSPTYISADDTMPGIEILDEQADVDNLTERRNRNRGTLPSSSAASSGAPQGASSKMMAIAREGMEADESIFGAEEQLAAQRHLWSDKYRPRKPTYLNRVQTGFDWNKYNQTHYDQDNPPPKIVQGYKFNIFYPDLLDMTVAPRFGLTSCEDPDFAIIRFKAGPPYEDIAFKVVNREWETLHKNGYKCQFQNGVFQLWFMFKKYRYRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-10-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G5EG14-3</accession>
    <name>CATIN_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cacn-1</name>
        <name type="ORF">W03H9.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Dev. Biol." volume="341" first="176" last="185">
            <title>CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans.</title>
            <authorList>
                <person name="Tannoury H."/>
                <person name="Rodriguez V."/>
                <person name="Kovacevic I."/>
                <person name="Ibourk M."/>
                <person name="Lee M."/>
                <person name="Cram E.J."/>
            </authorList>
            <dbReference type="PubMed" id="20188721"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.02.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EG14-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_044144"/>
        </isoform>
        <isoform>
            <id>G5EG14-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_044143"/>
        </isoform>
        <isoform>
            <id>G5EG14-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001254421.1">
        <property type="nucleotide sequence ID" value="NM_001267492.3"/>
    </dbReference>
    <dbReference type="WormBase" id="W03H9.4c">
        <property type="protein sequence ID" value="CE45519"/>
        <property type="gene ID" value="WBGene00012230"/>
        <property type="gene designation" value="cacn-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="196" mass="22807" checksum="7526F77A5EC98D2E" modified="2011-12-14" version="1">MPGIEILDEQADVDNLTERRNRNRGTLPSSSAASSGAPQGASSKMMAIAREGMEADESIFGAEEQLAAQRHLWSDKYRPRKPTYLNRVQTGFDWNKYNQTHYDQDNPPPKIVQGYKFNIFYPDLLDMTVAPRFGLTSCEDPDFAIIRFKAGPPYEDIAFKVVNREWETLHKNGYKCQFQNGVFQLWFMFKKYRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYB2</accession>
    <name>H2KYB2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">sup-37</name>
        <name evidence="11" type="ORF">C01B7.1</name>
        <name evidence="9" type="ORF">CELE_C01B7.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD62082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741578.1">
        <property type="nucleotide sequence ID" value="NM_171493.8"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYB2"/>
    <dbReference type="SMR" id="H2KYB2"/>
    <dbReference type="PeptideAtlas" id="H2KYB2"/>
    <dbReference type="GeneID" id="179257"/>
    <dbReference type="AGR" id="WB:WBGene00006342"/>
    <dbReference type="CTD" id="179257"/>
    <dbReference type="WormBase" id="C01B7.1a">
        <property type="protein sequence ID" value="CE29553"/>
        <property type="gene ID" value="WBGene00006342"/>
        <property type="gene designation" value="sup-37"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5844122at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006342">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYB2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048557">
        <property type="term" value="P:embryonic digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="668"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="910"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="186"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD62082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C01B7.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYB2"/>
        </source>
    </evidence>
    <sequence length="935" mass="103480" checksum="BA31E55B4BEFEB13" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYB4</accession>
    <name>H2KYB4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_ZC196.9</name>
        <name evidence="2 4" type="ORF">ZC196.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD62090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256105.1">
        <property type="nucleotide sequence ID" value="NM_001269176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYB4"/>
    <dbReference type="SMR" id="H2KYB4"/>
    <dbReference type="GeneID" id="191107"/>
    <dbReference type="KEGG" id="cel:CELE_ZC196.9"/>
    <dbReference type="AGR" id="WB:WBGene00022552"/>
    <dbReference type="CTD" id="191107"/>
    <dbReference type="WormBase" id="ZC196.9b">
        <property type="protein sequence ID" value="CE45867"/>
        <property type="gene ID" value="WBGene00022552"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1994674_0_0_1"/>
    <dbReference type="OrthoDB" id="5860892at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022552">
        <property type="expression patterns" value="Expressed in multicellular organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006874">
        <property type="entry name" value="DUF621"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31406:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31406">
        <property type="entry name" value="PROTEIN CBG06702-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04789">
        <property type="entry name" value="DUF621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD62090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZC196.9b"/>
        </source>
    </evidence>
    <sequence length="125" mass="14506" checksum="03FA6DBAB5BE47C8" modified="2012-03-21" version="1">MEKRLEGPMRELLLDISDSEKNWLYYSVVSLFVVSTIGATILTMSFLVLSILLWRHFKSMRFFWFLTQLTTSAFVISAANLFINIPAALSLFSKEVTQSHGNTCRCSHTFIFLFHIERNTETCFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYC1</accession>
    <name>H2KYC1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UNC93-like protein MFSD11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_Y39D8A.1</name>
        <name evidence="7 9" type="ORF">Y39D8A.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">Bristol N2</strain>
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    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
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    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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            <end position="69"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD62246.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y39D8A.1a"/>
        </source>
    </evidence>
    <sequence length="463" mass="51088" checksum="E02385428B87C11C" modified="2012-03-21" version="1">MNQRRFGLLCAVMLGFGQLCMFTGFDAESFILESVIHSIHEREPERISSYAGYYGQAVIYAFYMISCLFSPSIAAVSTPKINLILAATFFSAFPLGFLFTNSYYYYASSALVVFYQGQGGYLTSHSTRNTIESNVSISWSVGSCCMILGSAIMATITHLSSATTEHIMGSLNVTSEAHKMERQFGELEINLLFSAFTGISVLGIITFFVMPSKDVENCIESSSEKKETFLEALKLTCSTLVSPTMLQLFPLFVLSGFNTSFWLSVFPTAMSFTMQNSKLIYLAAVYSLGVGSGEVIIGLAISFLSKRIKDFGQKPTMTIGAIFITMYCAMIHMSTPYDAPIRPTSKEPLFFGHSYLLALIIGLFCGIGDCCVNSVRSVICALLMPKRRPQAFSVSKIYHAFGSTILFFMSPITPLYVYTIGLPILAIIATILFFSISKRTQIMERKMTEASKNAAEIGKKLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYC5</accession>
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        <submittedName>
            <fullName evidence="3">Apical junction molecule</fullName>
        </submittedName>
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        <name evidence="3 5" type="primary">ajm-1</name>
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    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD62270.2"/>
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        <property type="nucleotide sequence ID" value="NM_001381047.3"/>
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    <dbReference type="PeptideAtlas" id="H2KYC5"/>
    <dbReference type="GeneID" id="181148"/>
    <dbReference type="AGR" id="WB:WBGene00000100"/>
    <dbReference type="CTD" id="181148"/>
    <dbReference type="WormBase" id="C25A11.4b">
        <property type="protein sequence ID" value="CE51747"/>
        <property type="gene ID" value="WBGene00000100"/>
        <property type="gene designation" value="ajm-1"/>
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    <dbReference type="HOGENOM" id="CLU_004797_1_0_1"/>
    <dbReference type="OrthoDB" id="6431454at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000100">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYC5">
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    </dbReference>
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        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
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    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0000314"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0000304"/>
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        <property type="term" value="P:cell-cell junction organization"/>
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    </dbReference>
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        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
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        <property type="entry name" value="Apical_junction"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517:SF3">
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    </dbReference>
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    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="44"/>
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        <location>
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            <end position="1293"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD62270.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C25A11.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYC5"/>
        </source>
    </evidence>
    <sequence length="1293" mass="151464" checksum="854CF1DF71C7C04D" modified="2016-11-02" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYC7</accession>
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        <submittedName>
            <fullName evidence="2">Histone H1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">hil-7</name>
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        <name evidence="2" type="ORF">CELE_C01B10.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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    </dbReference>
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        <property type="gene ID" value="WBGene00001858"/>
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    </dbReference>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD62327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C01B10.5a"/>
        </source>
    </evidence>
    <sequence length="62" mass="6453" checksum="FF301204D637D406" modified="2012-03-21" version="1">MAAVQKAKKVAKTKKVAAKPKAPKVKKIQASPKKAAAPKAKKPVKKAAAKKSPAKKAAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYC8</accession>
    <name>H2KYC8_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">Histone H1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">hil-7</name>
        <name evidence="3" type="ORF">C01B10.5</name>
        <name evidence="1" type="ORF">CELE_C01B10.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD62330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367386.1">
        <property type="nucleotide sequence ID" value="NM_001380286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYC8"/>
    <dbReference type="SMR" id="H2KYC8"/>
    <dbReference type="GeneID" id="177433"/>
    <dbReference type="AGR" id="WB:WBGene00001858"/>
    <dbReference type="CTD" id="177433"/>
    <dbReference type="WormBase" id="C01B10.5e">
        <property type="protein sequence ID" value="CE33357"/>
        <property type="gene ID" value="WBGene00001858"/>
        <property type="gene designation" value="hil-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3320511_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001858">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYC8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD62330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C01B10.5e"/>
        </source>
    </evidence>
    <sequence length="39" mass="4356" checksum="5D184507C06555C5" modified="2012-03-21" version="1">MAAVQKAKKVAKTKKVAAKPKAPKVKKVRFLFISFIENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYD1</accession>
    <name>H2KYD1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SPK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="ORF">C16A11.4</name>
        <name evidence="6" type="ORF">CELE_C16A11.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD62426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122586.1">
        <property type="nucleotide sequence ID" value="NM_001129114.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYD1"/>
    <dbReference type="GeneID" id="173755"/>
    <dbReference type="KEGG" id="cel:CELE_C16A11.4"/>
    <dbReference type="AGR" id="WB:WBGene00015817"/>
    <dbReference type="CTD" id="173755"/>
    <dbReference type="WormBase" id="C16A11.4b">
        <property type="protein sequence ID" value="CE41103"/>
        <property type="gene ID" value="WBGene00015817"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877798at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015817">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYD1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053315">
        <property type="entry name" value="Peptidase_C14A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006570">
        <property type="entry name" value="SPK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23362">
        <property type="entry name" value="L-PLASTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23362:SF8">
        <property type="entry name" value="SPK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04435">
        <property type="entry name" value="SPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00583">
        <property type="entry name" value="SPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPK" evidence="5">
        <location>
            <begin position="113"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD62426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="C16A11.4b"/>
        </source>
    </evidence>
    <sequence length="510" mass="57979" checksum="1A669E25F7D7A7EF" modified="2012-03-21" version="1">MDDSSEEANQFEPPPAIRKSTRAVNNLSPHQKEVRCQCGTNNTDNRLIKCVECEKWQHAICMSVMPLDIIMTYKCEMCEPRLLMVSRSQARAYQGVEPEPREVRKKGRNQSVNLEEFLEFLSEASENISRPLALTTLFEDYKEHINYPQSVRILRKQLESNLLETISMSPNYYADRKAQMLFAMGLRVKGEFLERLERNAVVEVDGYHRITFYKSKNLEFRGKHRVGRFPLVNRRKSAESTSQQHGNSGNSRWNQFPVKQEIPDEQSFGSASTLPNAEIEPNLQYSLSDTMTTGSASTWNMAATPPSEMRGIMMESMNGLHALQSASYPPYQEMQEMLCVQHTMMKSMHEIIKTQSDFYREMFKTRAIAGAPPAPATTSLRAFLHFLKGYVDYLESEQLVDCSRLTQQHLETCRAADKLISMEKLLTGLAVATTIAEAHLSDVSAIINGASAMEFYKFIEIYASNQSNSAFSGLCTDLKQKIQALVNMDKKIPFKELSRAFRTAISLVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYD2</accession>
    <name>H2KYD2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rga-6</name>
        <name evidence="6" type="ORF">C01F4.2</name>
        <name evidence="4" type="ORF">CELE_C01F4.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD62430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491466.2">
        <property type="nucleotide sequence ID" value="NM_059065.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYD2"/>
    <dbReference type="GeneID" id="172102"/>
    <dbReference type="AGR" id="WB:WBGene00015303"/>
    <dbReference type="CTD" id="172102"/>
    <dbReference type="WormBase" id="C01F4.2b">
        <property type="protein sequence ID" value="CE33358"/>
        <property type="gene ID" value="WBGene00015303"/>
        <property type="gene designation" value="rga-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_439570_0_0_1"/>
    <dbReference type="OrthoDB" id="10024839at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015303">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYD2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037863">
        <property type="entry name" value="RHOGAP6/36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12635:SF7">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12635">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="512"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD62430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C01F4.2b"/>
        </source>
    </evidence>
    <sequence length="622" mass="67955" checksum="7ED5DD78B50D6CAF" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYD3</accession>
    <name>H2KYD3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F57C9.4</name>
        <name evidence="3 5" type="ORF">F57C9.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD62435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYD3"/>
    <dbReference type="SMR" id="H2KYD3"/>
    <dbReference type="PeptideAtlas" id="H2KYD3"/>
    <dbReference type="AGR" id="WB:WBGene00019011"/>
    <dbReference type="WormBase" id="F57C9.4a">
        <property type="protein sequence ID" value="CE28474"/>
        <property type="gene ID" value="WBGene00019011"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019011">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYD3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47645:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47645">
        <property type="entry name" value="PROTEIN CBG08267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD62435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F57C9.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYD3"/>
        </source>
    </evidence>
    <sequence length="653" mass="74194" checksum="E50A59132514916D" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYD5</accession>
    <name>H2KYD5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C01G8.1</name>
        <name evidence="2" type="ORF">CELE_C01G8.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD62466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122413.1">
        <property type="nucleotide sequence ID" value="NM_001128941.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYD5"/>
    <dbReference type="SMR" id="H2KYD5"/>
    <dbReference type="PeptideAtlas" id="H2KYD5"/>
    <dbReference type="GeneID" id="172170"/>
    <dbReference type="KEGG" id="cel:CELE_C01G8.1"/>
    <dbReference type="AGR" id="WB:WBGene00015312"/>
    <dbReference type="CTD" id="172170"/>
    <dbReference type="WormBase" id="C01G8.1b">
        <property type="protein sequence ID" value="CE41975"/>
        <property type="gene ID" value="WBGene00015312"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5786564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015312">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYD5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD62466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C01G8.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H2KYD5"/>
        </source>
    </evidence>
    <sequence length="314" mass="34243" checksum="63AA1F96929BC1AC" modified="2012-03-21" version="1">MLRRIKRFLGLSTHAYFPNNEVAPTADGSLISTMSRKSTKSERKAAKKEKKRSQLADTSAPAIFHVPTAPADIVTEGEGSTVGQGSEIDRRTVITDSLPYREPSDIYMGSPPSTVPQAPESSSSTRSLVGSDSIKSRLESMTIDGTSSVLQHVDSLTNSVYSAEFCQEVDSQNTCDAKSRELPVDCDIPTATEPLPISTKSNPVSNSSLTYMADVKLILPDKRDEKSEEVAGMKQLNAELDGLLKTSAPPFQVSTARLPPMLRELPPPANDESMLSGNDEFDDSKNNSVARYLNESHEVMMRSPENKHLRSCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYE6</accession>
    <name>H2KYE6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Inward rectifier potassium channel irk-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">irk-2</name>
        <name evidence="16" type="ORF">CELE_M02A10.2</name>
        <name evidence="18" type="ORF">M02A10.2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD62724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256977.1">
        <property type="nucleotide sequence ID" value="NM_001270048.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYE6"/>
    <dbReference type="SMR" id="H2KYE6"/>
    <dbReference type="GeneID" id="191695"/>
    <dbReference type="AGR" id="WB:WBGene00002150"/>
    <dbReference type="CTD" id="191695"/>
    <dbReference type="WormBase" id="M02A10.2a">
        <property type="protein sequence ID" value="CE43848"/>
        <property type="gene ID" value="WBGene00002150"/>
        <property type="gene designation" value="irk-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="PhylomeDB" id="H2KYE6"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002150">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYE6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000230">
        <property type="entry name" value="Inward Rectifying K (Potassium) channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="33"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="180"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD62724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="M02A10.2a"/>
        </source>
    </evidence>
    <sequence length="463" mass="53240" checksum="4A309EACC0F1010A" modified="2012-03-21" version="1">MLDIEEPLVKNKKYPFFKTPRLGGSRRIRNRLVQKQGLCNISLKNVPKQRRKYFSDIFTTVIEMKWRWCLLYFSLSFMISWSFFATVYFLIAKQHGDIEQIANATWTPCIVNVHNELNAFLFSFTTQTTIGYGFRYPTDACPLTIVTMCFQFMWGVMTQTLMAGIIFSKLARPIKRAATLIFSKNAVICLRDGKLCLLFRVGDMRKSSLAEAHVRLQMIKRCVTYEGELLPFHQFDMDVGYDQGLDRVFVIWPITICHEIDERSPLWEIGADDLKSAKFEIIAILEGVVESVGSTTQARTSYLPSEILWGHRFEKLVHYKKENGQYNIDFGKFHNVYSVNTPTCSAAEIERLRSEGIFNESEYQMYPPSDNKLNLLDNDEMSPVRDSIDLNQVPQIQILRRDSDEDPDAGEESMELVDLGIHHKCSIRSQSPIINSTSHLLQPMHKNSCSVRRGMLAPPASHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYE7</accession>
    <name>H2KYE7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C41A3.2</name>
        <name evidence="2" type="ORF">CELE_C41A3.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD62781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367415.1">
        <property type="nucleotide sequence ID" value="NM_001380969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYE7"/>
    <dbReference type="SMR" id="H2KYE7"/>
    <dbReference type="GeneID" id="180814"/>
    <dbReference type="KEGG" id="cel:CELE_C41A3.2"/>
    <dbReference type="AGR" id="WB:WBGene00016559"/>
    <dbReference type="CTD" id="180814"/>
    <dbReference type="WormBase" id="C41A3.2b">
        <property type="protein sequence ID" value="CE39138"/>
        <property type="gene ID" value="WBGene00016559"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518011_0_0_1"/>
    <dbReference type="OrthoDB" id="5849288at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016559">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYE7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD62781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C41A3.2b"/>
        </source>
    </evidence>
    <sequence length="526" mass="60781" checksum="0BDA52349ADC8D6F" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYE8</accession>
    <name>H2KYE8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HotDog ACOT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_D2021.4</name>
        <name evidence="2 4" type="ORF">D2021.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD62805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYE8"/>
    <dbReference type="SMR" id="H2KYE8"/>
    <dbReference type="PeptideAtlas" id="H2KYE8"/>
    <dbReference type="AGR" id="WB:WBGene00017048"/>
    <dbReference type="WormBase" id="D2021.4b">
        <property type="protein sequence ID" value="CE40033"/>
        <property type="gene ID" value="WBGene00017048"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2135745_0_0_1"/>
    <dbReference type="OrthoDB" id="5796505at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017048">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYE8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF66">
        <property type="entry name" value="THIOESTERASE_THIOL ESTER DEHYDRASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD62805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="D2021.4b"/>
        </source>
    </evidence>
    <sequence length="113" mass="12824" checksum="624891750715152C" modified="2012-03-21" version="1">MVTRPQLISAMLSIDNIDDNIYRSEGPHIGGIFGVNRLFGGYIAGQVYEAVRIYKNKIKDENVIFSMHYNFVSAGDPRKLIDIKIEKVGNVYTADVYHENKKIGLAHIKVRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYG8</accession>
    <name>H2KYG8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T26A5.2</name>
        <name evidence="2 4" type="ORF">T26A5.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63218.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYG8"/>
    <dbReference type="STRING" id="6239.T26A5.2a.1"/>
    <dbReference type="PaxDb" id="6239-T26A5.2a"/>
    <dbReference type="AGR" id="WB:WBGene00020819"/>
    <dbReference type="WormBase" id="T26A5.2a">
        <property type="protein sequence ID" value="CE54341"/>
        <property type="gene ID" value="WBGene00020819"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TH0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017461_0_0_1"/>
    <dbReference type="InParanoid" id="H2KYG8"/>
    <dbReference type="OrthoDB" id="5833282at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020819">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYG8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63218.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T26A5.2a"/>
        </source>
    </evidence>
    <sequence length="839" mass="96458" checksum="A9A39DD70AEDE56A" modified="2022-01-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYG9</accession>
    <name>H2KYG9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srh-2</name>
        <name evidence="4" type="ORF">C05E4.14</name>
        <name evidence="2" type="ORF">CELE_C05E4.14</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD63244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367443.1">
        <property type="nucleotide sequence ID" value="NM_001380592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2KYG9"/>
    <dbReference type="PaxDb" id="6239-C05E4.14c"/>
    <dbReference type="GeneID" id="178584"/>
    <dbReference type="AGR" id="WB:WBGene00005228"/>
    <dbReference type="CTD" id="178584"/>
    <dbReference type="WormBase" id="C05E4.14c">
        <property type="protein sequence ID" value="CE45153"/>
        <property type="gene ID" value="WBGene00005228"/>
        <property type="gene designation" value="srh-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047463_0_0_1"/>
    <dbReference type="PhylomeDB" id="H2KYG9"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005228">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H2KYG9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019422">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47405:SF3">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47405">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10318">
        <property type="entry name" value="7TM_GPCR_Srh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C05E4.14c"/>
        </source>
    </evidence>
    <sequence length="336" mass="38041" checksum="BFB4270366E884C5" modified="2012-03-21" version="1">MMETSYDRRALVLWFRRCSEAPNCGGAPAGKADFYGNIVGVGTCDIALDFLKSSHFFEVLAKSPLALLHFHFCGKCGILMEIHTGATWKISTSFPFPLCSNGFLGEYGPECFLILVVILIYNGLACIFIFLYRMEVASKHTAPTMLYKITHFQTYLLYFLLVMLSGITVFMYPVLKEQLDYKQRLEMKVGPIPTFMLCDSCVFMIYDSPIFLIWFLVAYICIALAYIILFSSGIVTYKALKVSRASAAVRKIQKNIFMSLVVSTITHLGLLFIPLATFFMLSLLVPEWSKSSIVKYTSDFMVIMIQQHGAVSAVTMFLTNNLLRRTAKQLFYTEMS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>O17405-2</accession>
    <name>PLDL_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Probable phospholipase D F09G2.8</fullName>
            <ecNumber>3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Choline phosphatase F09G2.8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Phosphatidylcholine-hydrolyzing phospholipase D F09G2.8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">F09G2.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="667" last="672">
            <title>Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Saito H."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Hirabayashi J."/>
                <person name="Kasai K."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="12754521"/>
            <dbReference type="DOI" id="10.1038/nbt829"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-333</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-333 AND ASN-350</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O17405-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_042410 VSP_042409"/>
        </isoform>
        <isoform>
            <id>O17405-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.4.4"/>
    <dbReference type="RefSeq" id="NP_001256080.1">
        <property type="nucleotide sequence ID" value="NM_001269151.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F09G2.8a">
        <property type="protein sequence ID" value="CE09303"/>
        <property type="gene ID" value="WBGene00017316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="516" mass="58573" checksum="62747B31104FAE57" modified="2012-02-22" version="2"> </sequence>
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<entry dataset="Swiss-Prot" created="1990-11-01" modified="2026-01-28" version="175" xmlns="https://uniprot.org/uniprot">
    <accession>P18948-2</accession>
    <name>VIT6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Vitellogenin-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">vit-6</name>
        <name type="ORF">K07H8.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1985" name="Mol. Cell. Biol." volume="5" first="2495" last="2501">
            <title>The Caenorhabditis elegans vitellogenin gene family includes a gene encoding a distantly related protein.</title>
            <authorList>
                <person name="Spieth J."/>
                <person name="Blumenthal T."/>
            </authorList>
            <dbReference type="PubMed" id="3841791"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-259</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1985" name="Nucleic Acids Res." volume="13" first="5283" last="5295">
            <title>The C. elegans vitellogenin genes: short sequence repeats in the promoter regions and homology to the vertebrate genes.</title>
            <authorList>
                <person name="Spieth J."/>
                <person name="Denison K."/>
                <person name="Kirtland S."/>
                <person name="Cane J."/>
                <person name="Blumenthal T."/>
            </authorList>
            <dbReference type="PubMed" id="4022780"/>
            <dbReference type="DOI" id="10.1093/nar/13.14.5283"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1991" name="J. Mol. Evol." volume="32" first="429" last="438">
            <title>Vitellogenin motifs conserved in nematodes and vertebrates.</title>
            <authorList>
                <person name="Spieth J."/>
                <person name="Nettleton M."/>
                <person name="Zucker-Aprison E."/>
                <person name="Lea K."/>
                <person name="Blumenthal T."/>
            </authorList>
            <dbReference type="PubMed" id="1904098"/>
            <dbReference type="DOI" id="10.1007/BF02101283"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORM A)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="Biochem. Biophys. Res. Commun." volume="264" first="580" last="583">
            <title>Vitellogenin-6 is a major carbonylated protein in aged nematode, Caenorhabditis elegans.</title>
            <authorList>
                <person name="Nakamura A."/>
                <person name="Yasuda K."/>
                <person name="Adachi H."/>
                <person name="Sakurai Y."/>
                <person name="Ishii N."/>
                <person name="Goto S."/>
            </authorList>
            <dbReference type="PubMed" id="10529405"/>
            <dbReference type="DOI" id="10.1006/bbrc.1999.1549"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 779-780 AND 1220-1232</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Glycobiology" volume="15" first="952" last="964">
            <title>Identification of the hydrophobic glycoproteins of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Fan X."/>
                <person name="She Y.-M."/>
                <person name="Bagshaw R.D."/>
                <person name="Callahan J.W."/>
                <person name="Schachter H."/>
                <person name="Mahuran D.J."/>
            </authorList>
            <dbReference type="PubMed" id="15888633"/>
            <dbReference type="DOI" id="10.1093/glycob/cwi075"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-252 AND ASN-1288</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1288</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2014" name="Genes Nutr." volume="9" first="414" last="414">
            <title>The zinc matrix metalloproteinase ZMP-2 increases survival of Caenorhabditis elegans through interference with lipoprotein absorption.</title>
            <authorList>
                <person name="Fischer M."/>
                <person name="Fitzenberger E."/>
                <person name="Kull R."/>
                <person name="Boll M."/>
                <person name="Wenzel U."/>
            </authorList>
            <dbReference type="PubMed" id="24957743"/>
            <dbReference type="DOI" id="10.1007/s12263-014-0414-6"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P18948-1</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P18948-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_020107"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001023274.1">
        <property type="nucleotide sequence ID" value="NM_001028103.4"/>
    </dbReference>
    <dbReference type="WormBase" id="K07H8.6a">
        <property type="protein sequence ID" value="CE28594"/>
        <property type="gene ID" value="WBGene00006930"/>
        <property type="gene designation" value="vit-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="1650" mass="193219" checksum="8258153500C48673" modified="2006-09-05" version="5" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="178" xmlns="https://uniprot.org/uniprot">
    <accession>P34374-2</accession>
    <name>UNC36_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Voltage-dependent calcium channel unc-36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Pharyngeal calcium channel subunit alpha-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Uncoordinated protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">unc-36</name>
        <name type="synonym">unc-72</name>
        <name type="ORF">C50C3.9/C50C3.10/C50C3.11</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Genetics" volume="133" first="897" last="917">
            <title>The genetics of feeding in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Avery L."/>
            </authorList>
            <dbReference type="PubMed" id="8462849"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1996" name="Genetics" volume="143" first="1219" last="1230">
            <title>Genes affecting sensitivity to serotonin in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Schafer W.R."/>
                <person name="Sanchez B.M."/>
                <person name="Kenyon C.J."/>
            </authorList>
            <dbReference type="PubMed" id="8807295"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="Cell" volume="99" first="387" last="398">
            <title>Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans.</title>
            <authorList>
                <person name="Troemel E.R."/>
                <person name="Sagasti A."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="10571181"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(00)81525-1"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="J. Neurobiol." volume="66" first="1125" last="1139">
            <title>Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons.</title>
            <authorList>
                <person name="Frokjaer-Jensen C."/>
                <person name="Kindt K.S."/>
                <person name="Kerr R.A."/>
                <person name="Suzuki H."/>
                <person name="Melnik-Martinez K."/>
                <person name="Gerstbreih B."/>
                <person name="Driscol M."/>
                <person name="Schafer W.R."/>
            </authorList>
            <dbReference type="PubMed" id="16838374"/>
            <dbReference type="DOI" id="10.1002/neu.20261"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-100 AND ASN-757</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34374-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_036007"/>
        </isoform>
        <isoform>
            <id>P34374-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001040852.1">
        <property type="nucleotide sequence ID" value="NM_001047387.4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="104" mass="11942" checksum="A36E1FA05E6E9B46" modified="2003-05-16" version="2" precursor="true">MEASFVDGTNLVMVWITQDKASENCYDESECSMEISNQVPFGFEEVKNEETCEENEKRKSKANDVCYSIDDDDSENERRPCSTSPTIVSIFQILFGVFLHFCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-05-01" modified="2025-10-08" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>P90946</accession>
    <name>P90946_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_R13H4.7</name>
        <name evidence="6 8" type="ORF">R13H4.7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB04652.4"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256381.1">
        <property type="nucleotide sequence ID" value="NM_001269452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P90946"/>
    <dbReference type="SMR" id="P90946"/>
    <dbReference type="GeneID" id="187874"/>
    <dbReference type="UCSC" id="R13H4.7">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00011265"/>
    <dbReference type="CTD" id="187874"/>
    <dbReference type="WormBase" id="R13H4.7a">
        <property type="protein sequence ID" value="CE43990"/>
        <property type="gene ID" value="WBGene00011265"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061652_1_0_1"/>
    <dbReference type="OrthoDB" id="5774177at2759"/>
    <dbReference type="PhylomeDB" id="P90946"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011265">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="P90946">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
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    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
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    <dbReference type="PANTHER" id="PTHR24238:SF20">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB04652.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="R13H4.7a"/>
        </source>
    </evidence>
    <sequence length="341" mass="39400" checksum="E1AFA86E2469EF9F" modified="2009-09-22" version="4">MDASDAAAGIFLLLFGIVGCALYGLIVCSMWRMVNEIVGFRFLISQALTDILLMIQFGIWPGIVILTQNEIINESWRWNIHIYLDFTWWAMVYHYTVIAWSRLAAVQWPNWFRTLPHGTSIMICAIPWFTGLLQSLVEHQFDWFTPLFYSPTRYGMHSDWEKYELSGTNTYYMVCNVILMVVPFPLYVLALAVLFQRQTSRNMQLRSKYSHAPISTSSYAAQQRQLSIETRLLVPCIINTILFVVGQVFISQCSKHGKWMNWAVMVVFATNSFVNPLLYLFFSSVIRKGVLSNCRKNFSLSAIYNDYEMRSSPRTSSIVMRLNHRDSTITSNLNCRVNSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-05-01" modified="2025-10-08" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>P90958</accession>
    <name>P90958_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">vap-2</name>
        <name evidence="3" type="ORF">CELE_T05A10.5</name>
        <name evidence="5" type="ORF">T05A10.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAA92136.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_509802.2">
        <property type="nucleotide sequence ID" value="NM_077401.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P90958"/>
    <dbReference type="SMR" id="P90958"/>
    <dbReference type="GeneID" id="181273"/>
    <dbReference type="UCSC" id="T05A10.5">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011462"/>
    <dbReference type="CTD" id="181273"/>
    <dbReference type="WormBase" id="T05A10.5a">
        <property type="protein sequence ID" value="CE44291"/>
        <property type="gene ID" value="WBGene00011462"/>
        <property type="gene designation" value="vap-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645976_0_0_1"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="PhylomeDB" id="P90958"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011462">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="P90958">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004161447" evidence="1">
        <location>
            <begin position="20"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="69"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="280"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA92136.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T05A10.5a"/>
        </source>
    </evidence>
    <sequence length="473" mass="54121" checksum="1170F86A03E580A0" modified="2010-01-19" version="2">MNVVLSAVTLFLIFRYAQTVNIEGSGGNDELLEQNVWNDVDDKVVEALGGLDDELLTEHVCNKSTITQLQQEIILTTHNELRRSLAFGKQRNKRGLMNGARNMYKLDWDCELASLAANWSTSCPQHFMPQSVLGSNAQLFKRFYFYFDGHDSTVHMRNAMKYWWQQGEEKGNEDQKNRFYARRNYFGWANMAKGKTYRVGCSYIMCGDGESALFTCLYNEKAQCEKEMIYENGKPCCEDKDCFTYPGSKCLVPEGLCQAPSMVKDDGGSFQCDNSLVSDVTRNFTLEQHNFYRSRLAKGFEWNGETNTSQPKASQMIKMEYDCMLERFAQNWANNCVFAHSAHYERPNQGQNLYMSSFSNPDPRSLIHTAVEKWWQELEEFGTPIDNVLTPELWDLKGKAIGHYTQMAWDRTYRLGCGIANCPKMSYVVCHYGPAGNRKNNKIYEIGDPCEVDDDCPIGTDCEKTTSLCVISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-06-13" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q1HB00</accession>
    <name>Q1HB00_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F57B1.6</name>
        <name evidence="2 4" type="ORF">F57B1.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAK12566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041129.1">
        <property type="nucleotide sequence ID" value="NM_001047664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1HB00"/>
    <dbReference type="GeneID" id="179805"/>
    <dbReference type="UCSC" id="F57B1.6a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010189"/>
    <dbReference type="CTD" id="179805"/>
    <dbReference type="WormBase" id="F57B1.6b">
        <property type="protein sequence ID" value="CE40233"/>
        <property type="gene ID" value="WBGene00010189"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1397535_0_0_1"/>
    <dbReference type="OrthoDB" id="5867138at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010189">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1HB00">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAK12566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F57B1.6b"/>
        </source>
    </evidence>
    <sequence length="195" mass="21557" checksum="EE6718D89104ED78" modified="2006-06-13" version="1">MQTSTFIFCCNIALVIVSISGLCLTSSVFDFIVVSRLYYTVPDHKVLINPRMAFWLFPSSTFSLILSFLSLLFLSAGPRVIKFAVDNQMILSLAHALLMCGACILSSFVSFICAQNANDIAGYAAFATPAQFQLASAWYYSRLRALVVISVIQSLLNGIIVSTLYLGISCKYRTFVQLAEKPPQQGLIERTTYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-06-13" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q1HB03</accession>
    <name>Q1HB03_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serpentine Receptor, class D (Delta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">srd-35</name>
        <name evidence="1" type="ORF">CELE_R186.2</name>
        <name evidence="3" type="ORF">R186.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAK12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041153.1">
        <property type="nucleotide sequence ID" value="NM_001047688.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1HB03"/>
    <dbReference type="GeneID" id="187918"/>
    <dbReference type="UCSC" id="R186.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00005113"/>
    <dbReference type="CTD" id="187918"/>
    <dbReference type="WormBase" id="R186.2b">
        <property type="protein sequence ID" value="CE40235"/>
        <property type="gene ID" value="WBGene00005113"/>
        <property type="gene designation" value="srd-35"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057924_2_0_1"/>
    <dbReference type="OrthoDB" id="5873158at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005113">
        <property type="expression patterns" value="Expressed in embryo and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1HB03">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAK12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="R186.2b"/>
        </source>
    </evidence>
    <sequence length="52" mass="5924" checksum="AF214443CD43C1A8" modified="2006-06-13" version="1">MAMSPNLAASFDPLINLYFVVPYRTKIKSWFGKKHQQTSTIRIASLTPSGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-06-13" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q1HB04</accession>
    <name>Q1HB04_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">anp-1</name>
        <name evidence="16" type="ORF">CELE_T07F10.1</name>
        <name evidence="18" type="ORF">T07F10.1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="BX284605">
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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        <ligand>
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    <feature type="binding site" evidence="9">
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        <ligand>
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    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="471"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11838"/>
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        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CAK12563.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="1995" name="Cell" volume="83" first="207" last="218">
            <title>Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans.</title>
            <authorList>
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                <person name="Chou J.H."/>
                <person name="Dwyer N.D."/>
                <person name="Colbert H.A."/>
                <person name="Bargmann C.I."/>
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            <dbReference type="DOI" id="10.1016/0092-8674(95)90162-0"/>
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        <scope>TISSUE SPECIFICITY</scope>
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    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
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            <authorList>
                <person name="Robinson-Rechavi M."/>
                <person name="Maina C.V."/>
                <person name="Gissendanner C.R."/>
                <person name="Laudet V."/>
                <person name="Sluder A."/>
            </authorList>
            <dbReference type="PubMed" id="15983867"/>
            <dbReference type="DOI" id="10.1007/s00239-004-0175-8"/>
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        <event type="alternative splicing"/>
        <isoform>
            <id>Q21006-4</id>
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        <isoform>
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            <sequence type="described" ref="VSP_003725 VSP_020156"/>
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        <isoform>
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        <isoform>
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    </comment>
    <dbReference type="UCSC" id="F58G6.5a">
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    <proteinExistence type="evidence at transcript level"/>
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</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2026-01-28" version="193" xmlns="https://uniprot.org/uniprot">
    <accession>Q21006-2</accession>
    <name>NHR34_CAEEL</name>
    <protein>
        <recommendedName>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="J. Mol. Evol." volume="60" first="577" last="586">
            <title>Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes.</title>
            <authorList>
                <person name="Robinson-Rechavi M."/>
                <person name="Maina C.V."/>
                <person name="Gissendanner C.R."/>
                <person name="Laudet V."/>
                <person name="Sluder A."/>
            </authorList>
            <dbReference type="PubMed" id="15983867"/>
            <dbReference type="DOI" id="10.1007/s00239-004-0175-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21006-1</id>
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            <sequence type="described" ref="VSP_020155"/>
        </isoform>
        <isoform>
            <id>Q21006-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_020156 VSP_003725"/>
        </isoform>
        <isoform>
            <id>Q21006-3</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q21006-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_053631"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741480.1">
        <property type="nucleotide sequence ID" value="NM_171412.5"/>
    </dbReference>
    <dbReference type="WormBase" id="F58G6.5a">
        <property type="protein sequence ID" value="CE27764"/>
        <property type="gene ID" value="WBGene00003627"/>
        <property type="gene designation" value="nhr-34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="499" mass="57088" checksum="2E13343C94AE11D8" modified="2006-09-05" version="3">MAESKFSILKGEEFTGLKCRVCGDSRAGRHYGTIACNGCKGFFRRSIWEQRDYVCRFGGKCLVVQEYRNRCRACRLRKCFTVGMDARAVQSERDKHKKNPKDSNNEGSTSPQYPTASTPISIPSTSTSQTPTSSVNSYNFQNIPGIVSRSFSENLIMRDNSVPVMETSQSAALSHVPLVRYLIDLEKATDNLIDENCDFMSMEFDQLCRVDVTIEAAFRQPGVVAKRTPPRWLALERLTTLEDVHIAWCRSFVLCIDYAKIMKDYQELSPTDQFTLLRNRVISVNWLCHTYKTFKAGCDGVALVNGSWYPRDKELQKQLDPGCNHYFRILSEHLMEDLVIPMREMDMDEGEFVILKALILFRAHRRLSEEGRAHIKRVRDKYIEALYQHVQHQHRHFSSVQTSMRISKILLLLPSIEHLSQQEDDNVQFLALFNLANLNGLPYELHSSIKQHIPNGDDSDDTQVNEVTSNNDGPRSSESSHTPQSVSTSQFLEFKPSLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2026-01-28" version="193" xmlns="https://uniprot.org/uniprot">
    <accession>Q21006-4</accession>
    <name>NHR34_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform d of Nuclear hormone receptor family member nhr-34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nhr-34</name>
        <name type="ORF">F58G6.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="J. Mol. Evol." volume="60" first="577" last="586">
            <title>Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes.</title>
            <authorList>
                <person name="Robinson-Rechavi M."/>
                <person name="Maina C.V."/>
                <person name="Gissendanner C.R."/>
                <person name="Laudet V."/>
                <person name="Sluder A."/>
            </authorList>
            <dbReference type="PubMed" id="15983867"/>
            <dbReference type="DOI" id="10.1007/s00239-004-0175-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21006-3</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q21006-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_053631"/>
        </isoform>
        <isoform>
            <id>Q21006-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_003725 VSP_020156"/>
        </isoform>
        <isoform>
            <id>Q21006-1</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020155"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001129859.1">
        <property type="nucleotide sequence ID" value="NM_001136387.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F58G6.5d">
        <property type="protein sequence ID" value="CE42612"/>
        <property type="gene ID" value="WBGene00003627"/>
        <property type="gene designation" value="nhr-34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="563" mass="63633" checksum="5F0B487DC9529DA4" modified="2006-09-05" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6U4</accession>
    <name>Q2L6U4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein containing ALS2cr12 (ALS2CR12) signature</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pals-11</name>
        <name evidence="4" type="ORF">C17H1.13</name>
        <name evidence="2" type="ORF">CELE_C17H1.13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ58494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040636.1">
        <property type="nucleotide sequence ID" value="NM_001047171.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6U4"/>
    <dbReference type="SMR" id="Q2L6U4"/>
    <dbReference type="GeneID" id="4363012"/>
    <dbReference type="KEGG" id="cel:CELE_C17H1.13"/>
    <dbReference type="UCSC" id="C17H1.13">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00044708"/>
    <dbReference type="CTD" id="4363012"/>
    <dbReference type="WormBase" id="C17H1.13a">
        <property type="protein sequence ID" value="CE39559"/>
        <property type="gene ID" value="WBGene00044708"/>
        <property type="gene designation" value="pals-11"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_915972_0_0_1"/>
    <dbReference type="PhylomeDB" id="Q2L6U4"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044708">
        <property type="expression patterns" value="Expressed in adult organism"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6U4">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ58494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C17H1.13a"/>
        </source>
    </evidence>
    <sequence length="293" mass="34355" checksum="DAA30E5D04A0AEA9" modified="2006-02-21" version="1">MKELREEQRIALADKKKSNNSELENKRNELQLEEEQFRSNIQNMEHSMRMQAKEEQRSDIENHELRKREIIEKHQETISNLNRSMSEAEKSMREQKFIHQTKCEEIDLKMKLKQGDLAKAVRNDILEEKYNSTVQHVKHIWALISKAVTVVHKSLSNDDKQTISTRNREILVTLVKNKMDNLEEASEKVSNFKGYDGMKGGANTNVVKQILNKIVDVRNSLNTFLSTFSELDKSITAFKAFKDRMNMLNYAVSKLRNIKLKKHADIEIRNMELILYEWKKDCESAQNSKSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6U6</accession>
    <name>Q2L6U6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CELE_D2023.1</name>
        <name evidence="16 18" type="ORF">D2023.1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAJ58492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T20347">
        <property type="entry name" value="T20347"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6U6"/>
    <dbReference type="SMR" id="Q2L6U6"/>
    <dbReference type="UCSC" id="D2023.1d">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00014300"/>
    <dbReference type="WormBase" id="D2023.1b">
        <property type="protein sequence ID" value="CE09071"/>
        <property type="gene ID" value="WBGene00014300"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102602_3_2_1"/>
    <dbReference type="OMA" id="PEHEQTH"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="PhylomeDB" id="Q2L6U6"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014300">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6U6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAJ58492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="D2023.1b"/>
        </source>
    </evidence>
    <sequence length="103" mass="11495" checksum="3FFF1516FBEA4D4E" modified="2006-02-21" version="1">MSDSIITRSEVNMHCSEDDCWIIVGNYVYDVTKFVDLHPGGPEILLEFAGGDATDAFESVGHSMCARMMLTKFKIGSLPEDERPDFIQAEYITHAKISLPMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6U7</accession>
    <name>Q2L6U7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GST C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F55A11.6</name>
        <name evidence="3 5" type="ORF">F55A11.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAJ58499.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041124.2">
        <property type="nucleotide sequence ID" value="NM_001047659.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6U7"/>
    <dbReference type="SMR" id="Q2L6U7"/>
    <dbReference type="GeneID" id="179613"/>
    <dbReference type="UCSC" id="F55A11.6a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010079"/>
    <dbReference type="CTD" id="179613"/>
    <dbReference type="WormBase" id="F55A11.6b">
        <property type="protein sequence ID" value="CE40967"/>
        <property type="gene ID" value="WBGene00010079"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_937616_0_0_1"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010079">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6U7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000310">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000077">
        <property type="entry name" value="Protein CBG23268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF256">
        <property type="entry name" value="GST C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ58499.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F55A11.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q2L6U7"/>
        </source>
    </evidence>
    <sequence length="218" mass="25791" checksum="A00312F047AE6096" modified="2007-06-26" version="2">MDTMHGFLVPTYTLHDFDDGEECKVVRMIFQMSRVPYEFKHVHRDDYILEDYPFYALPTLEMNERKYGSVLSICRHLAWRYNLSGKTAYDDAQVDDIAEKVFEVRMKIKNWIDHIEHAADHACDEECTEEIAPRILTNTLFPCLERMLKSAASCWLVGHTMTWVDLLVACLVNPIIYHRPKLLQDFPLLYLHNEKVAHHDDLVGFLYHVRTRKFQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-02-21" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L6U9</accession>
    <name>Q2L6U9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Papain family cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_R07E3.1</name>
        <name evidence="10 12" type="ORF">R07E3.1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAJ58500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041281.1">
        <property type="nucleotide sequence ID" value="NM_001047816.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L6U9"/>
    <dbReference type="SMR" id="Q2L6U9"/>
    <dbReference type="MEROPS" id="C01.A43"/>
    <dbReference type="PeptideAtlas" id="Q2L6U9"/>
    <dbReference type="GeneID" id="181242"/>
    <dbReference type="UCSC" id="R07E3.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011102"/>
    <dbReference type="CTD" id="181242"/>
    <dbReference type="WormBase" id="R07E3.1b">
        <property type="protein sequence ID" value="CE39608"/>
        <property type="gene ID" value="WBGene00011102"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012184_1_3_1"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011102">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2L6U9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000103">
        <property type="entry name" value="Hypothetical LOC496748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012519891" evidence="7">
        <location>
            <begin position="16"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="36"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="132"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAJ58500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="R07E3.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="Q2L6U9"/>
        </source>
    </evidence>
    <sequence length="348" mass="39356" checksum="A124843493F7A9DE" modified="2006-02-21" version="1">MFIIFVVPLFTKLQAEKVSRRAHTNERGIQNIAKEYIAYTEKFDKSYATSQESLKRLNAYYNTDENIANWNIQNEHGSAEYGHNDMSDWTDEEFEKTLLPKSFYKRLHKEAEFIEPIPESLTAKKGESSSPFPDFFDWRDKNVITPVKAQGQCGSCWAFASTATVEAAWAIAHGEKRNLSEQTLLDCDLVDNACDGGDEDKAFRYIHRNGLANAVDLPYVAHRQNGCAVNDHWNTTRIKAAYFLHHDEDSIINWLVNFGPVNIGMAVIQPMRAYKGGVFTPSEYACKNEVIGLHALLITGYGTSKTGEKYWIVKNSWGNTWGVEHGYIYFARGINACGIEDEPIGILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-08-02" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q4JFB7</accession>
    <name>Q4JFB7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gla-3</name>
        <name evidence="7" type="ORF">CELE_T02E1.3</name>
        <name evidence="9" type="ORF">T02E1.3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB04667.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_492238.2">
        <property type="nucleotide sequence ID" value="NM_059837.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4JFB7"/>
    <dbReference type="SMR" id="Q4JFB7"/>
    <dbReference type="IntAct" id="Q4JFB7">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="172604"/>
    <dbReference type="UCSC" id="T02E1.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011376"/>
    <dbReference type="CTD" id="172604"/>
    <dbReference type="WormBase" id="T02E1.3a">
        <property type="protein sequence ID" value="CE32481"/>
        <property type="gene ID" value="WBGene00011376"/>
        <property type="gene designation" value="gla-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5844568at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011376">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q4JFB7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CCCH zinc finger"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="C18F3.2d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="Q53U86"/>
        </source>
    </evidence>
    <sequence length="1147" mass="127880" checksum="803AFCBCB18A645E" modified="2005-05-24" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-08-30" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q564Q1-2</accession>
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        <alternativeName>
            <fullName evidence="3">Galactowaldenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylgalactosamine 4-epimerase</fullName>
            <shortName evidence="1">UDP-GalNAc 4-epimerase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylglucosamine 4-epimerase</fullName>
            <shortName evidence="1">UDP-GlcNAc 4-epimerase</shortName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="2">UDP-galactose 4-epimerase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="7" type="primary">gale-1</name>
        <name evidence="7" type="ORF">C47B2.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2014" name="Genetics" volume="198" first="1559" last="1569">
            <title>Developmental defects in a Caenorhabditis elegans model for type III galactosemia.</title>
            <authorList>
                <person name="Brokate-Llanos A.M."/>
                <person name="Monje J.M."/>
                <person name="Murdoch P."/>
                <person name="Munoz M.J."/>
            </authorList>
            <dbReference type="PubMed" id="25298520"/>
            <dbReference type="DOI" id="10.1534/genetics.114.170084"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF PRO-314</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q564Q1-2</id>
            <name evidence="6">a</name>
            <sequence type="described" ref="VSP_059051"/>
        </isoform>
        <isoform>
            <id>Q564Q1-1</id>
            <name evidence="7">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="4"/>
    <dbReference type="EC" id="5.1.3.7" evidence="4"/>
    <dbReference type="RefSeq" id="NP_001021051.1">
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    </dbReference>
    <dbReference type="WormBase" id="C47B2.6a">
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        <property type="gene ID" value="WBGene00008132"/>
        <property type="gene designation" value="gale-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q14376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="25298520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="25298520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C47B2.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C47B2.6b"/>
        </source>
    </evidence>
    <sequence length="347" mass="37683" checksum="7F727FBFF7BE37AB" modified="2005-05-10" version="1">MHILVTGAAGFIGSHTVLELLNSGYTVLCIDNFANAISDEHGNAISLKRVAQLTGKDVPFQNVDVCDEAALEKVFSENKFDGIIHLAALKAVGESVAKPLQYYSNNLVASLNLIQMCLKYNVKNFVFSSSATVYGPPSELPITEKSQTGQGITNPYGQTKYMMEQILIDVGKANPEWNVVLLRYFNPVGAHKSGLIGEDPKGVPNNLMPYVSQVAIGKLPVLTIYGDQFDTVDGTGVRDYIHVVDLAKGHVKAFDRIKTVGNIGTEIYNLGTGVGYSVRQMVDALKKVSGRDIPVKIGVPRPGDVASVYCDPSLAQEKLGWRAETGLEEMCADLWNWQTKNPQGFSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2026-01-28" version="160" xmlns="https://uniprot.org/uniprot">
    <accession>Q6BER5-2</accession>
    <name>NU301_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Nucleosome-remodeling factor subunit NURF301-like</fullName>
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    <gene>
        <name type="primary">nurf-1</name>
        <name type="ORF">F26H11.2</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Development" volume="133" first="2695" last="2704">
            <title>C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.</title>
            <authorList>
                <person name="Andersen E.C."/>
                <person name="Lu X."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="16774993"/>
            <dbReference type="DOI" id="10.1242/dev.02444"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q6BER5-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_020411 VSP_020420"/>
        </isoform>
        <isoform>
            <id>Q6BER5-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_020413"/>
        </isoform>
        <isoform>
            <id>Q6BER5-1</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q6BER5-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_020410 VSP_020421"/>
        </isoform>
        <isoform>
            <id>Q6BER5-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020415 VSP_020418"/>
        </isoform>
        <isoform>
            <id>Q6BER5-3</id>
            <name>a</name>
            <sequence type="described" ref="VSP_044204"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_496994.3">
        <property type="nucleotide sequence ID" value="NM_064593.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F26H11.2b">
        <property type="protein sequence ID" value="CE46841"/>
        <property type="gene ID" value="WBGene00009180"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="1621" mass="185717" checksum="FF400C89951C0A92" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2026-01-28" version="160" xmlns="https://uniprot.org/uniprot">
    <accession>Q6BER5-3</accession>
    <name>NU301_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Nucleosome-remodeling factor subunit NURF301-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nurf-1</name>
        <name type="ORF">F26H11.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Development" volume="133" first="2695" last="2704">
            <title>C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.</title>
            <authorList>
                <person name="Andersen E.C."/>
                <person name="Lu X."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="16774993"/>
            <dbReference type="DOI" id="10.1242/dev.02444"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q6BER5-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_020413"/>
        </isoform>
        <isoform>
            <id>Q6BER5-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020418 VSP_020415"/>
        </isoform>
        <isoform>
            <id>Q6BER5-3</id>
            <name>a</name>
            <sequence type="described" ref="VSP_044204"/>
        </isoform>
        <isoform>
            <id>Q6BER5-1</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q6BER5-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_020410 VSP_020421"/>
        </isoform>
        <isoform>
            <id>Q6BER5-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_020420 VSP_020411"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_496995.3">
        <property type="nucleotide sequence ID" value="NM_064594.9"/>
    </dbReference>
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        <property type="gene ID" value="WBGene00009180"/>
        <property type="gene designation" value="nurf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="2197" mass="252551" checksum="965F4D71C150C834" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2026-01-28" version="160" xmlns="https://uniprot.org/uniprot">
    <accession>Q6BER5-4</accession>
    <name>NU301_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform d of Nucleosome-remodeling factor subunit NURF301-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nurf-1</name>
        <name type="ORF">F26H11.2</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
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            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Development" volume="133" first="2695" last="2704">
            <title>C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.</title>
            <authorList>
                <person name="Andersen E.C."/>
                <person name="Lu X."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="16774993"/>
            <dbReference type="DOI" id="10.1242/dev.02444"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q6BER5-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020415 VSP_020418"/>
        </isoform>
        <isoform>
            <id>Q6BER5-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_020410 VSP_020421"/>
        </isoform>
        <isoform>
            <id>Q6BER5-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_020413"/>
        </isoform>
        <isoform>
            <id>Q6BER5-1</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q6BER5-3</id>
            <name>a</name>
            <sequence type="described" ref="VSP_044204"/>
        </isoform>
        <isoform>
            <id>Q6BER5-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_020411 VSP_020420"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379249.1">
        <property type="nucleotide sequence ID" value="NM_001393233.1"/>
    </dbReference>
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        <property type="gene ID" value="WBGene00009180"/>
        <property type="gene designation" value="nurf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2026-01-28" version="160" xmlns="https://uniprot.org/uniprot">
    <accession>Q6BER5-5</accession>
    <name>NU301_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform e of Nucleosome-remodeling factor subunit NURF301-like</fullName>
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    </protein>
    <gene>
        <name type="primary">nurf-1</name>
        <name type="ORF">F26H11.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Development" volume="133" first="2695" last="2704">
            <title>C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.</title>
            <authorList>
                <person name="Andersen E.C."/>
                <person name="Lu X."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="16774993"/>
            <dbReference type="DOI" id="10.1242/dev.02444"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q6BER5-3</id>
            <name>a</name>
            <sequence type="described" ref="VSP_044204"/>
        </isoform>
        <isoform>
            <id>Q6BER5-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_020413"/>
        </isoform>
        <isoform>
            <id>Q6BER5-1</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q6BER5-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_020410 VSP_020421"/>
        </isoform>
        <isoform>
            <id>Q6BER5-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_020420 VSP_020411"/>
        </isoform>
        <isoform>
            <id>Q6BER5-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020415 VSP_020418"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022119.1">
        <property type="nucleotide sequence ID" value="NM_001026948.6"/>
    </dbReference>
    <dbReference type="WormBase" id="F26H11.2e">
        <property type="protein sequence ID" value="CE15909"/>
        <property type="gene ID" value="WBGene00009180"/>
        <property type="gene designation" value="nurf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="405" mass="46199" checksum="DE6BE7384A5AEB2F" modified="2012-10-03" version="2">MKALHVFFLPAAKPKAEVKKEVINPADITLGGDTYDYVKEQKPTESIATNVSRRRRTSANLSKSEDDRDKPESQSTAPKSKERRTSEPPASHVAFHTPGSATPHDINLSIEHCTCQKIFDASKLYIQCELCARWYHGDCVGVAEQTILGLEHWSCEECIEEQERVKDQPALYCVCQKPYDDTKFYVGCDSCQGWFHPECVGTTRAEAEQAADYNCPACTREAEGYESEASDVSGSSRVSVQLTRADYTHVFELLELLLEHRMSTPFRNPVDLNEFPDYEKFIKKPMDLSTITKKVERTEYLYLSQFVNDVNQMFENAKTYNPKGNAVFKCAETMQEVFDKKLIDVREQMTARQQMLLLATAQQQDPMSSIRKRVQSESQRTVDSLDIDSDQLLPLDANLMRLYDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2026-01-28" version="160" xmlns="https://uniprot.org/uniprot">
    <accession>Q6BER5-6</accession>
    <name>NU301_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform f of Nucleosome-remodeling factor subunit NURF301-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nurf-1</name>
        <name type="ORF">F26H11.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Development" volume="133" first="2695" last="2704">
            <title>C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.</title>
            <authorList>
                <person name="Andersen E.C."/>
                <person name="Lu X."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="16774993"/>
            <dbReference type="DOI" id="10.1242/dev.02444"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q6BER5-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_020411 VSP_020420"/>
        </isoform>
        <isoform>
            <id>Q6BER5-3</id>
            <name>a</name>
            <sequence type="described" ref="VSP_044204"/>
        </isoform>
        <isoform>
            <id>Q6BER5-1</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q6BER5-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_020413"/>
        </isoform>
        <isoform>
            <id>Q6BER5-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020415 VSP_020418"/>
        </isoform>
        <isoform>
            <id>Q6BER5-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_020410 VSP_020421"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022120.1">
        <property type="nucleotide sequence ID" value="NM_001026949.5"/>
    </dbReference>
    <dbReference type="WormBase" id="F26H11.2f">
        <property type="protein sequence ID" value="CE15910"/>
        <property type="gene ID" value="WBGene00009180"/>
        <property type="gene designation" value="nurf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="510" mass="57881" checksum="C567A57D0DBE160F" modified="2012-10-03" version="2">MVLRTVILPTATYTAPSQYCPSTVLSNLTLSCPYQDQEADASLEISDFAEVLPKFESAEQDWNSFGYLLNEQPGTSSDKTTTPIKKITVFQKPVEPIGKGPRRRRRCADREISELAAKPKAEVKKEVINPADITLGGDTYDYVKEQKPTESIATNVSRRRRTSANLSKSEDDRDKPESQSTAPKSKERRTSEPPASHVAFHTPGSATPHDINLSIEHCTCQKIFDASKLYIQCELCARWYHGDCVGVAEQTILGLEHWSCEECIEEQERVKDQPALYCVCQKPYDDTKFYVGCDSCQGWFHPECVGTTRAEAEQAADYNCPACTREAEGYESEASDVSGSSRVSVQLTRADYTHVFELLELLLEHRMSTPFRNPVDLNEFPDYEKFIKKPMDLSTITKKVERTEYLYLSQFVNDVNQMFENAKTYNPKGNAVFKCAETMQEVFDKKLIDVREQMTARQQMLLLATAQQQDPMSSIRKRVQSESQRTVDSLDIDSDQLLPLDANLMRLYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JKL2</accession>
    <name>Q7JKL2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Equilibrative nucleoside transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ent-4</name>
        <name evidence="10" type="synonym">ent-6</name>
        <name evidence="10" type="ORF">C47A4.2</name>
        <name evidence="8" type="ORF">CELE_C47A4.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAE46670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023068.1">
        <property type="nucleotide sequence ID" value="NM_001027897.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JKL2"/>
    <dbReference type="SMR" id="Q7JKL2"/>
    <dbReference type="GeneID" id="178339"/>
    <dbReference type="KEGG" id="cel:CELE_C47A4.2"/>
    <dbReference type="UCSC" id="C47A4.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008123"/>
    <dbReference type="CTD" id="178339"/>
    <dbReference type="WormBase" id="C47A4.2a">
        <property type="protein sequence ID" value="CE35435"/>
        <property type="gene ID" value="WBGene00008123"/>
        <property type="gene designation" value="ent-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008123">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JKL2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF36">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE46670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="C47A4.2a"/>
        </source>
    </evidence>
    <sequence length="445" mass="49789" checksum="E088AE11B3F00FF7" modified="2004-07-05" version="1">MEKEFVDPPPLYTQDQNTEDLASIVDGADSSDEHNELIPEDKGRIVFWIILLNGIGVLLPWNMFITIAPQYYVDYWFTVNGTATHYADSFQSAMGVVAQVPNLIVAIINVLNLIRGPLLYRVLAPLAFNSLLIVIILALVIFQQPSDQARNWFYIVSLIIVMAMNASNGLYQNSFFGMAADFPAKYSNAVVIGTNICGTFTSVLAIVATLAFSTQAETVALIYFGISLLILFVCLVSWWFCKKMDFYKYYVSKGNRLRAAQEQSSFDYRPYLETIKYCWLQCICVFLVYFVSLSVFPTVLAGFQPGYTVFPNDVYAGIAVFLNFNFFAAVGNVAATFVTFPGPRLLIVPCVIRLLFIPFFMFSNYLPHSRTMGVLFTNEWIFFFGNTLLAFTSGYFSSLGMMYTPRVCPPEYSKLAGQVSALSLVLGITAGVSFTYAITAMVNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q7YWT5</accession>
    <name>Q7YWT5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_T23B5.4</name>
        <name evidence="7 9" type="ORF">T23B5.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAE17950.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255661.1">
        <property type="nucleotide sequence ID" value="NM_001268732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7YWT5"/>
    <dbReference type="SMR" id="Q7YWT5"/>
    <dbReference type="GeneID" id="3565854"/>
    <dbReference type="UCSC" id="T23B5.4">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011941"/>
    <dbReference type="CTD" id="3565854"/>
    <dbReference type="WormBase" id="T23B5.4a">
        <property type="protein sequence ID" value="CE45582"/>
        <property type="gene ID" value="WBGene00011941"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="PhylomeDB" id="Q7YWT5"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011941">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7YWT5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="26"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE17950.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="T23B5.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q7YWT5"/>
        </source>
    </evidence>
    <sequence length="133" mass="15672" checksum="F50F5FB4D8281A24" modified="2011-02-08" version="2">MILKWTLIRRMLATPKQKLKNYKFPDVRKEDCEQKYISGWGPGGQKVNTAQNAVQLTHLPTGTVLKVHESRLLPKNIDIAFERMKFVLDRQINGENCYEEQLKRLQIAKEEKSNKRRVQARKEKESYKNESVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXE4</accession>
    <name>Q8MXE4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dipeptidyl Peptidase Four (IV) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">dpf-7</name>
        <name evidence="1" type="ORF">CELE_R11E3.7</name>
        <name evidence="3" type="ORF">R11E3.7</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD72243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367922.1">
        <property type="nucleotide sequence ID" value="NM_001380209.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXE4"/>
    <dbReference type="PeptideAtlas" id="Q8MXE4"/>
    <dbReference type="GeneID" id="177250"/>
    <dbReference type="KEGG" id="cel:CELE_R11E3.7"/>
    <dbReference type="UCSC" id="R11E3.7a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001060"/>
    <dbReference type="CTD" id="177250"/>
    <dbReference type="WormBase" id="R11E3.7b">
        <property type="protein sequence ID" value="CE31721"/>
        <property type="gene ID" value="WBGene00001060"/>
        <property type="gene designation" value="dpf-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1620536_0_0_1"/>
    <dbReference type="OrthoDB" id="5868991at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001060">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXE4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD72243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="R11E3.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MXE4"/>
        </source>
    </evidence>
    <sequence length="164" mass="19532" checksum="092571362B56B5CC" modified="2002-10-01" version="1">MSTDEEVPLATRQMHEAFVTISQQMLQFRVNTARITTPSDYEPQEVWVIYETLECPDQRQYMRSRGLVSRNKLWMLMETETDKDWKYFTHIFSDDCKVCVFVAESIEMGHDKDVIQVEDVQYKKAKFTDQMLISNFLEIIKNCSTLHYQMKNKRKRRDVVSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="166" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXE5</accession>
    <name>Q8MXE5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nhr-104</name>
        <name evidence="13" type="ORF">CELE_R11E3.5</name>
        <name evidence="15" type="ORF">R11E3.5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD72240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741385.1">
        <property type="nucleotide sequence ID" value="NM_171327.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXE5"/>
    <dbReference type="SMR" id="Q8MXE5"/>
    <dbReference type="GeneID" id="177248"/>
    <dbReference type="UCSC" id="R11E3.5a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003694"/>
    <dbReference type="CTD" id="177248"/>
    <dbReference type="WormBase" id="R11E3.5b">
        <property type="protein sequence ID" value="CE31720"/>
        <property type="gene ID" value="WBGene00003694"/>
        <property type="gene designation" value="nhr-104"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007368_1_1_1"/>
    <dbReference type="OrthoDB" id="5830034at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003694">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXE5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011:SF13">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-86-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="120"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD72240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="R11E3.5b"/>
        </source>
    </evidence>
    <sequence length="242" mass="28206" checksum="DA585997F2E7A585" modified="2002-10-01" version="1">MRFNPCDVCLSPGNGKHFGVDACRGCTAFFRRTIVNKRNYSCSEDDTCEIEKSEGLLCKKCRFEKCLKVGMKKESIQKHRDIYGRRNPENRALIISPSTSQLQVTIPITLLSSVKRNYAELENVREIVHRMDGFSMFLKPAPRGQTYKETYRLLLREFYLVSDWVSNCFPLFKELPNSQKDILLRNFYLTFYNLEAGFFACQHNKIDVWFLPNGNFIDCQNLEAFYYDPHNQQPMTSADAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXE9</accession>
    <name>Q8MXE9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FERM and PDZ domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">frm-8</name>
        <name evidence="5" type="ORF">CELE_H09G03.2</name>
        <name evidence="7" type="ORF">H09G03.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD72288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741110.1">
        <property type="nucleotide sequence ID" value="NM_171097.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXE9"/>
    <dbReference type="SMR" id="Q8MXE9"/>
    <dbReference type="GeneID" id="175428"/>
    <dbReference type="UCSC" id="H09G03.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001494"/>
    <dbReference type="CTD" id="175428"/>
    <dbReference type="WormBase" id="H09G03.2a">
        <property type="protein sequence ID" value="CE31024"/>
        <property type="gene ID" value="WBGene00001494"/>
        <property type="gene designation" value="frm-8"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859304at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001494">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXE9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17088">
        <property type="entry name" value="FERM_F1_FRMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000036">
        <property type="entry name" value="FERM domain (Protein4.1-ezrin-radixin-moesin) family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF3">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
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    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="95"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="3">
        <location>
            <begin position="208"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD72288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="H09G03.2a"/>
        </source>
    </evidence>
    <sequence length="814" mass="91389" checksum="4232CF8820BE768F" modified="2002-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXF3</accession>
    <name>Q8MXF3_CAEEL</name>
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        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="8 10" type="primary">hrpa-2</name>
        <name evidence="8" type="ORF">CELE_H28G03.1</name>
        <name evidence="10" type="ORF">H28G03.1</name>
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    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD72473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380004.1">
        <property type="nucleotide sequence ID" value="NM_001392774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXF3"/>
    <dbReference type="SMR" id="Q8MXF3"/>
    <dbReference type="GeneID" id="180791"/>
    <dbReference type="KEGG" id="cel:CELE_H28G03.1"/>
    <dbReference type="UCSC" id="H28G03.1a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019249"/>
    <dbReference type="CTD" id="180791"/>
    <dbReference type="WormBase" id="H28G03.1c">
        <property type="protein sequence ID" value="CE31190"/>
        <property type="gene ID" value="WBGene00019249"/>
        <property type="gene designation" value="hrpa-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6019873at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019249">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXF3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098687">
        <property type="term" value="C:chromosomal region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000040">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A2/B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001345">
        <property type="entry name" value="Protein CBG14639"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF17">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="335"/>
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    </feature>
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        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD72473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="H28G03.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MXF3"/>
        </source>
    </evidence>
    <sequence length="335" mass="37673" checksum="31593BC7871E35FD" modified="2002-10-01" version="1">MYGPYPYPPEVAEMIQSGGFPFAMMNRGMPPPPQWNGYPVIHPYELHQMLRFQQMGMGQYQHDSPPQLRKLFIGGLSHDTTDEQLGNYFSQWGPVVDAIVIRDPNTKHSRGFGFVTFASIFSAESAMNDRPHKLGGKTVDSKRAIPREQMSSMIPPPFFETDPAPGCKLLLNGITNGVHSVDSLRVYFETFGTLDQVEILGQPRGLGFVIYEDKESADRCLAHNSGRHIVNERKIEVRVFTKHPNGSTYWKRPQSQSHSQRDLFEQLSQLNLKDGDRKSTGNSSSAADTPQNFDEDSNYGGTTTEDDCNVFEHEEGSSEESSTEQTLENEKENSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXI7</accession>
    <name>Q8MXI7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 196</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F37C4.4</name>
        <name evidence="3 5" type="ORF">F37C4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD70195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXI7"/>
    <dbReference type="UCSC" id="F37C4.4b.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018144"/>
    <dbReference type="WormBase" id="F37C4.4b">
        <property type="protein sequence ID" value="CE31505"/>
        <property type="gene ID" value="WBGene00018144"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5822050at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018144">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXI7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD70195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F37C4.4b"/>
        </source>
    </evidence>
    <sequence length="237" mass="26610" checksum="BBC8D0B4F4FC97C7" modified="2002-10-01" version="1">MGLLRPNFEEPTARLMPGPVTSEEEEEFSSNERRRYKAYTVMQKAGFQHTEYAQIMVHLCRAEILISLIFLAHGTTCPGYPTEAEYQSTCHMNTVSAIVSLLTGAMGLGAVHRYRWRTMLILWLVFCIMSAVGSLLAVITTGIWLDHYSKMKVRTAIGNGLSGFMLLASVALGVCFILTAVMICHYWNSNTTGYQPVQKIAKRARSLRRRLSRAKSCDKKDARPPTSNPEDKGYHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXJ1</accession>
    <name>Q8MXJ1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aggrecan core protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T23E7.2</name>
        <name evidence="2 4" type="ORF">T23E7.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD83565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXJ1"/>
    <dbReference type="PeptideAtlas" id="Q8MXJ1"/>
    <dbReference type="UCSC" id="T23E7.2e">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020732"/>
    <dbReference type="WormBase" id="T23E7.2e">
        <property type="protein sequence ID" value="CE31244"/>
        <property type="gene ID" value="WBGene00020732"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870358at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020732">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXJ1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD83565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T23E7.2e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MXJ1"/>
        </source>
    </evidence>
    <sequence length="908" mass="98284" checksum="11C0CD0C7EA6F0E4" modified="2002-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXJ3</accession>
    <name>Q8MXJ3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">math-3</name>
        <name evidence="4" type="ORF">C08F1.4</name>
        <name evidence="2" type="ORF">CELE_C08F1.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD63711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367464.1">
        <property type="nucleotide sequence ID" value="NM_001381336.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXJ3"/>
    <dbReference type="SMR" id="Q8MXJ3"/>
    <dbReference type="GeneID" id="173547"/>
    <dbReference type="KEGG" id="cel:CELE_C08F1.4"/>
    <dbReference type="UCSC" id="C08F1.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00015608"/>
    <dbReference type="CTD" id="173547"/>
    <dbReference type="WormBase" id="C08F1.4b">
        <property type="protein sequence ID" value="CE31771"/>
        <property type="gene ID" value="WBGene00015608"/>
        <property type="gene designation" value="math-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622931_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015608">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXJ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46308">
        <property type="entry name" value="MATH (MEPRIN-ASSOCIATED TRAF HOMOLOGY) DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46308:SF1">
        <property type="entry name" value="MATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00917">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C08F1.4b"/>
        </source>
    </evidence>
    <sequence length="225" mass="26927" checksum="34A4F3A94F739F95" modified="2002-10-01" version="1">MKGYRKLMKWEKLVSNHLVNDSVTVEADLNVFNLAGYKIFDKSTTKKFVLSQQFSDVSRIEEGESRFSRFEKRFNIPWRIELQRVSGFLEIHLHRGIEIEKPDDVFTIIKADCWFNLVSTNGKNLMRQMSAVFCRDVDMESLKKVIRWDDMMTDYVINDSFIIEAHIEILRIIEKKNFSPNWLSYMKPVFYERCFYITCKVNNVSRFQDGEKQWGNTELRYDIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXJ7</accession>
    <name>Q8MXJ7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">alh-4</name>
        <name evidence="8" type="ORF">CELE_T05H4.13</name>
        <name evidence="10" type="ORF">T05H4.13</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD72038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741554.1">
        <property type="nucleotide sequence ID" value="NM_171472.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXJ7"/>
    <dbReference type="SMR" id="Q8MXJ7"/>
    <dbReference type="GeneID" id="179026"/>
    <dbReference type="UCSC" id="T05H4.13a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000110"/>
    <dbReference type="CTD" id="179026"/>
    <dbReference type="WormBase" id="T05H4.13b">
        <property type="protein sequence ID" value="CE30827"/>
        <property type="gene ID" value="WBGene00000110"/>
        <property type="gene designation" value="alh-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000110">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXJ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07087">
        <property type="entry name" value="ALDH_F3-13-14_CALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD72038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="T05H4.13b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MXJ7"/>
        </source>
    </evidence>
    <sequence length="493" mass="55553" checksum="9590C0ADA1831AE5" modified="2002-10-01" version="1">MAFTELVETQRKYFRTGETKPVKFRKQQLLKLKKFIEENREALSEAVWKDLRRRHESTEILEIGMTIQEIDYFLKNIDDWVKPTHVEKTFTTALDKPVIEKDPKGVVLIISPWNYPVSMILLPMVPAIAAGNTVVIKPSELSENVAATFEKLIPKYFESKYVTVVNGGIPETTDLLKERFDHILYTGCPPVAKIIMTAAAKHLTPVTLELGGKCPVVVEDDADIDISAKRIAWGKWLNCGQTCLAPDYILVNSTVKPKLVAAIRKYVNEFYGEDVKASKDYARMINQRHFDRISGLLDKTQGAVLIGGERDRADLYIPPTVLDVEKSDPFMHDEIFGPVLPIITVQSFSESLEYIADGEKPLAAYIFTRNEAKVKRLLNETSSGGVTVNDVLMHITVDTLPFGGVGVSGMGRYRGKYGFDTFTHEKSVLHRGFFGESLLAARYPPLSQQKLDQMRRLTGKRISLNLMNVATLPIVMASFVFGMLFQFIFRFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="177" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXK0</accession>
    <name>Q8MXK0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear Hormone Receptor family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">nhr-142</name>
        <name evidence="15" type="ORF">CELE_F44E7.8</name>
        <name evidence="17" type="ORF">F44E7.8</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD67867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_504518.3">
        <property type="nucleotide sequence ID" value="NM_072117.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXK0"/>
    <dbReference type="SMR" id="Q8MXK0"/>
    <dbReference type="IntAct" id="Q8MXK0">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="185740"/>
    <dbReference type="UCSC" id="F44E7.8">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018430"/>
    <dbReference type="CTD" id="185740"/>
    <dbReference type="WormBase" id="F44E7.8a">
        <property type="protein sequence ID" value="CE35972"/>
        <property type="gene ID" value="WBGene00018430"/>
        <property type="gene designation" value="nhr-142"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007368_7_0_1"/>
    <dbReference type="OrthoDB" id="10018779at2759"/>
    <dbReference type="PhylomeDB" id="Q8MXK0"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018430">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXK0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051152">
        <property type="entry name" value="C.elegans_Orphan_NR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680:SF29">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="140"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD67867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="F44E7.8a"/>
        </source>
    </evidence>
    <sequence length="417" mass="48607" checksum="6ABF14C2A892FEAA" modified="2004-03-01" version="2">MSPPAFIEQSRMSVDQPSSSSSDSECRVCAHTAHGVHFGVLSCRACAAFFRRSVVMDKKYSCRKASQGCRIDKSERYLCRLCRYKKCLQLGMTADNVQWNRDMISSTDRKRQSEEDDATDVDAYSDWSPGSKKSCLDAPPLYDLSRTLNKIHKTFMEFKIPVDDPVYQSTSTLGKMDWALRRHRKNKKMQNFRIINTIRLDQLVDMWGMEMTKQAEFMMHSEEFRELSLEEKFSIFKLVWQVSQRFEKLTMSLEIFGKRAIEEKILITSNSTAIRMEDVEIDLSKITDYTSLELRKMFQHVCSQMYEEVARPLMELDPSTIEISYMLCQIIWHIAGKTLQGDILDAGEKFIGKIADDLHQYYLKEYKMSNYAGRLIKLMTVVNSLQRIHLDRLKIMELAKIFEVFKVKVTDPCVFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MXK1</accession>
    <name>Q8MXK1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Insulin-degrading enzyme</fullName>
            <ecNumber evidence="8">3.4.24.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Insulin protease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Insulysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CELE_F44E7.4</name>
        <name evidence="16 18" type="ORF">F44E7.4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Degradation of insulin, glucagon and other polypeptides. No action on proteins.</text>
            <dbReference type="EC" id="3.4.24.56"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.56" evidence="8"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD67861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741542.1">
        <property type="nucleotide sequence ID" value="NM_171461.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MXK1"/>
    <dbReference type="SMR" id="Q8MXK1"/>
    <dbReference type="MEROPS" id="M16.A09"/>
    <dbReference type="PeptideAtlas" id="Q8MXK1"/>
    <dbReference type="GeneID" id="178966"/>
    <dbReference type="UCSC" id="F44E7.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018426"/>
    <dbReference type="CTD" id="178966"/>
    <dbReference type="WormBase" id="F44E7.4b">
        <property type="protein sequence ID" value="CE30799"/>
        <property type="gene ID" value="WBGene00018426"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7784541at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018426">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MXK1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000066">
        <property type="entry name" value="Putative zinc protease mug138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="13">
        <location>
            <begin position="95"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="14">
        <location>
            <begin position="259"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="15">
        <location>
            <begin position="444"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="14">
        <location>
            <begin position="731"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD67861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="F44E7.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MXK1"/>
        </source>
    </evidence>
    <sequence length="1051" mass="120130" checksum="EBB83366D0007B45" modified="2002-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2026-01-28" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>Q9GSX9-2</accession>
    <name>RIC8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Chaperone ric-8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Resistance to inhibitors of cholinesterase protein 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Synembryn</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ric-8</name>
        <name type="ORF">Y69A2AR.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Genetics" volume="156" first="1649" last="1660">
            <title>A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Miller K.G."/>
                <person name="Rand J.B."/>
            </authorList>
            <dbReference type="PubMed" id="11102364"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Neuron" volume="27" first="289" last="299">
            <title>RIC-8 (Synembryn): a novel conserved protein that is required for Gq alpha signaling in the C. elegans nervous system.</title>
            <authorList>
                <person name="Miller K.G."/>
                <person name="Emerson M.D."/>
                <person name="McManus J.R."/>
                <person name="Rand J.B."/>
            </authorList>
            <dbReference type="PubMed" id="10985349"/>
            <dbReference type="DOI" id="10.1016/S0896-6273(00)00037-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF LEU-267 AND ALA-275</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Cell" volume="119" first="209" last="218">
            <title>RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans.</title>
            <authorList>
                <person name="Hess H.A."/>
                <person name="Roeper J.-C."/>
                <person name="Grill S.W."/>
                <person name="Koelle M.R."/>
            </authorList>
            <dbReference type="PubMed" id="15479638"/>
            <dbReference type="DOI" id="10.1016/j.cell.2004.09.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH GOA-1</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="Cell" volume="119" first="219" last="230">
            <title>RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos.</title>
            <authorList>
                <person name="Afshar K."/>
                <person name="Willard F.S."/>
                <person name="Colombo K."/>
                <person name="Johnston C.A."/>
                <person name="McCudden C.R."/>
                <person name="Siderovski D.P."/>
                <person name="Goenczy P."/>
            </authorList>
            <dbReference type="PubMed" id="15479639"/>
            <dbReference type="DOI" id="10.1016/j.cell.2004.09.026"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH GOA-1</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="Curr. Biol." volume="14" first="1871" last="1876">
            <title>Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8.</title>
            <authorList>
                <person name="Couwenbergs C."/>
                <person name="Spilker A.C."/>
                <person name="Gotta M."/>
            </authorList>
            <dbReference type="PubMed" id="15498497"/>
            <dbReference type="DOI" id="10.1016/j.cub.2004.09.059"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH GOA-1</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="Development" volume="132" first="4449" last="4459">
            <title>Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division.</title>
            <authorList>
                <person name="Afshar K."/>
                <person name="Willard F.S."/>
                <person name="Colombo K."/>
                <person name="Siderovski D.P."/>
                <person name="Goenczy P."/>
            </authorList>
            <dbReference type="PubMed" id="16162648"/>
            <dbReference type="DOI" id="10.1242/dev.02039"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH GPA-16</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2005" name="Genetics" volume="169" first="631" last="649">
            <title>Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network.</title>
            <authorList>
                <person name="Schade M.A."/>
                <person name="Reynolds N.K."/>
                <person name="Dollins C.M."/>
                <person name="Miller K.G."/>
            </authorList>
            <dbReference type="PubMed" id="15489510"/>
            <dbReference type="DOI" id="10.1534/genetics.104.032334"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2005" name="Genetics" volume="169" first="651" last="670">
            <title>Convergent, RIC-8-dependent Galpha signaling pathways in the Caenorhabditis elegans synaptic signaling network.</title>
            <authorList>
                <person name="Reynolds N.K."/>
                <person name="Schade M.A."/>
                <person name="Miller K.G."/>
            </authorList>
            <dbReference type="PubMed" id="15489511"/>
            <dbReference type="DOI" id="10.1534/genetics.104.031286"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2018" name="Sci. Signal." volume="11" first="eaap8113" last="eaap8113">
            <title>Dual phosphorylation of Ric-8A enhances its ability to mediate G protein alpha subunit folding and to stimulate guanine nucleotide exchange.</title>
            <authorList>
                <person name="Papasergi-Scott M.M."/>
                <person name="Stoveken H.M."/>
                <person name="MacConnachie L."/>
                <person name="Chan P.-Y."/>
                <person name="Gabay M."/>
                <person name="Wong D."/>
                <person name="Freeman R.S."/>
                <person name="Beg A.A."/>
                <person name="Tall G.G."/>
            </authorList>
            <dbReference type="PubMed" id="29844055"/>
            <dbReference type="DOI" id="10.1126/scisignal.aap8113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF SER-467 AND SER-472</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9GSX9-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_018516 VSP_018517"/>
        </isoform>
        <isoform>
            <id>Q9GSX9-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001421841.1">
        <property type="nucleotide sequence ID" value="NM_001434912.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y69A2AR.2b">
        <property type="protein sequence ID" value="CE33952"/>
        <property type="gene ID" value="WBGene00004367"/>
        <property type="gene designation" value="ric-8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="157" mass="17438" checksum="7A61D0D2EE8F6325" modified="2001-03-01" version="1">MSEELHSDLIASIFGGKPAKIEEFFSKWNFANAAVSKFDMANSAKNELGDRICEVIENGELTHVLLETIKILSREKDGLEGLLNDPLCDKILAFAELSSNENNSKTVHSKAILSLKILEFPAKNHNFSTNGGAKMSNQHFVSLTTNERSILCKPENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2025-10-08" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N3E5</accession>
    <name>Q9N3E5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rom-5</name>
        <name evidence="11" type="ORF">CELE_Y54E10A.14</name>
        <name evidence="13" type="ORF">Y54E10A.14</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD72837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491125.4">
        <property type="nucleotide sequence ID" value="NM_058724.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N3E5"/>
    <dbReference type="STRING" id="6239.Y54E10A.14.1"/>
    <dbReference type="PaxDb" id="6239-Y54E10A.14"/>
    <dbReference type="GeneID" id="190260"/>
    <dbReference type="UCSC" id="Y54E10A.14">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004404"/>
    <dbReference type="CTD" id="190260"/>
    <dbReference type="WormBase" id="Y54E10A.14a">
        <property type="protein sequence ID" value="CE45659"/>
        <property type="gene ID" value="WBGene00004404"/>
        <property type="gene designation" value="rom-5"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034022_0_0_1"/>
    <dbReference type="OMA" id="ASIVEIW"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="PhylomeDB" id="Q9N3E5"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004404">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000012">
        <property type="entry name" value="Rhomboid family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="161"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD72837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="Y54E10A.14a"/>
        </source>
    </evidence>
    <sequence length="325" mass="36487" checksum="D253226967E00779" modified="2011-02-08" version="3">MLSNRLVGFLCSRSFTKCTSLPSRFTRDGLRDRLRQQELKELTKNHQIKQAFSPDARTVRPMSDLWKALQFTLATGVTTFSIAIVADSWNRRKEERTAPINVFDAVEAGIEYKLTNGEKHLALLIGLNVVVYLMWKGKSLNPFMTRYFTNSYASKSLCSPMLLSAFSHSSIIHLGLNMYVLSTFAPHIIEKFMGVEQFWSFYVTAAVVSSFVSIVDKAVVRSPIRALGASGAILAALTYTCMQIPDGRLSLVFIPNFDFSAQNAVYGIIAFDLLGLLLRFRLFDHAAHLGGSLFGVGYALFLQDALWEKYGEWLENLLFSSSEDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2026-01-28" version="167" xmlns="https://uniprot.org/uniprot">
    <accession>Q9U308-2</accession>
    <name>JAC1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Juxtamembrane domain-associated catenin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>p120 catenin homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">jac-1</name>
        <name type="ORF">Y105C5B.21</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Genetics" volume="159" first="159" last="172">
            <title>The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo.</title>
            <authorList>
                <person name="Natarajan L."/>
                <person name="Witwer N.E."/>
                <person name="Eisenmann D.M."/>
            </authorList>
            <dbReference type="PubMed" id="11560894"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="J. Cell Biol." volume="162" first="15" last="22">
            <title>The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis.</title>
            <authorList>
                <person name="Pettitt J."/>
                <person name="Cox E.A."/>
                <person name="Broadbent I.D."/>
                <person name="Flett A."/>
                <person name="Hardin J."/>
            </authorList>
            <dbReference type="PubMed" id="12847081"/>
            <dbReference type="DOI" id="10.1083/jcb.200212136"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HMR-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2015" name="Nat. Cell Biol." volume="17" first="726" last="735">
            <title>An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity.</title>
            <authorList>
                <person name="Klompstra D."/>
                <person name="Anderson D.C."/>
                <person name="Yeh J.Y."/>
                <person name="Zilberman Y."/>
                <person name="Nance J."/>
            </authorList>
            <dbReference type="PubMed" id="25938815"/>
            <dbReference type="DOI" id="10.1038/ncb3168"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ASSOCIATION WITH THE CATENIN-CADHERIN COMPLEX</scope>
        <scope>INTERACTION WITH PICC-1 AND HMR-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9U308-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_021980"/>
        </isoform>
        <isoform>
            <id>Q9U308-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001041008.1">
        <property type="nucleotide sequence ID" value="NM_001047543.4"/>
    </dbReference>
    <dbReference type="WormBase" id="Y105C5B.21b">
        <property type="protein sequence ID" value="CE39806"/>
        <property type="gene ID" value="WBGene00002175"/>
        <property type="gene designation" value="jac-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="1084" mass="119316" checksum="6B0C7214A8EB6926" modified="2003-03-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEA1</accession>
    <name>U4PEA1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_ZK185.1</name>
        <name evidence="2 4" type="ORF">ZK185.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294335.1">
        <property type="nucleotide sequence ID" value="NM_001307406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEA1"/>
    <dbReference type="SMR" id="U4PEA1"/>
    <dbReference type="GeneID" id="191242"/>
    <dbReference type="AGR" id="WB:WBGene00022681"/>
    <dbReference type="CTD" id="191242"/>
    <dbReference type="WormBase" id="ZK185.1d">
        <property type="protein sequence ID" value="CE48818"/>
        <property type="gene ID" value="WBGene00022681"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051735_0_0_1"/>
    <dbReference type="OrthoDB" id="5855987at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022681">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEA1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34850:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34850">
        <property type="entry name" value="PROTEIN CBG21297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZK185.1d"/>
        </source>
    </evidence>
    <sequence length="196" mass="22516" checksum="2E156C054A7FABCF" modified="2013-12-11" version="1">MRHLQVNFQEVSQTLTEGIVLKLQIASTSYTIIFSFHKVDKARRRIKREMARKSLERRLRVLELRCARTWVPDDDVVFKKKRTSEENKALIQALKLPATSSHDDIVLKINEMKTQHDEMVNNVYTNNVKPNGQIMSAEEKRLISSLTNDMVTPVSGKRKTTFKNPSELQQSSRKRQKTLSPASQSPPEPAATRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U4PEA7</accession>
    <name>U4PEA7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_R05C11.4</name>
        <name evidence="1 3" type="ORF">R05C11.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PEA7"/>
    <dbReference type="AGR" id="WB:WBGene00044467"/>
    <dbReference type="WormBase" id="R05C11.4b">
        <property type="protein sequence ID" value="CE48757"/>
        <property type="gene ID" value="WBGene00044467"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1379246_0_0_1"/>
    <dbReference type="OrthoDB" id="5873684at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044467">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PEA7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDH93053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="R05C11.4b"/>
        </source>
    </evidence>
    <sequence length="74" mass="8392" checksum="F79C542443A7A841" modified="2013-12-11" version="1">MYQSIHMITRSNESPSALYRPVDQIPPKMYEAPPPYECFVPPPVVATSSTDNNEWNCILENEVNGSRRTPPQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>W6RRU8</accession>
    <name>W6RRU8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">CCR4-NOT transcription complex subunit 4</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">CCR4-associated factor 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">E3 ubiquitin-protein ligase CNOT4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Potential transcriptional repressor NOT4Hp</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">RING-type E3 ubiquitin transferase CNOT4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30 32" type="primary">ntl-4</name>
        <name evidence="32" type="ORF">C49H3.5</name>
        <name evidence="30" type="ORF">CELE_C49H3.5</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with CNOT1 via its C-terminus but does not stably associate with the CCR4-NOT complex. Interacts (via RING domain) with UBE2D2. Interacts with ABCE1, PINK1 and PELO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294150.1">
        <property type="nucleotide sequence ID" value="NM_001307221.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RRU8"/>
    <dbReference type="SMR" id="W6RRU8"/>
    <dbReference type="IntAct" id="W6RRU8">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="177580"/>
    <dbReference type="KEGG" id="cel:CELE_C49H3.5"/>
    <dbReference type="AGR" id="WB:WBGene00003827"/>
    <dbReference type="CTD" id="177580"/>
    <dbReference type="WormBase" id="C49H3.5c">
        <property type="protein sequence ID" value="CE49549"/>
        <property type="gene ID" value="WBGene00003827"/>
        <property type="gene designation" value="ntl-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003827">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RRU8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000044">
        <property type="entry name" value="Putative ccr4-not transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 26" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="28">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="29">
        <location>
            <begin position="108"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="291"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="527"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="589"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="683"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="CDM63496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="WormBase" id="C49H3.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="33">
        <source>
            <dbReference type="PeptideAtlas" id="W6RRU8"/>
        </source>
    </evidence>
    <sequence length="794" mass="90020" checksum="7F90F1C0162577FD" modified="2014-04-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6RRW5</accession>
    <name>W6RRW5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Neuropeptide-Like Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C49H3.12</name>
        <name evidence="1" type="ORF">CELE_C49H3.12</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368438.1">
        <property type="nucleotide sequence ID" value="NM_001380348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RRW5"/>
    <dbReference type="GeneID" id="183629"/>
    <dbReference type="KEGG" id="cel:CELE_C49H3.12"/>
    <dbReference type="AGR" id="WB:WBGene00016795"/>
    <dbReference type="CTD" id="183629"/>
    <dbReference type="WormBase" id="C49H3.12b">
        <property type="protein sequence ID" value="CE49514"/>
        <property type="gene ID" value="WBGene00016795"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131703_0_0_1"/>
    <dbReference type="OrthoDB" id="5876210at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016795">
        <property type="expression patterns" value="Expressed in material anatomical entity and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RRW5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM63501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C49H3.12b"/>
        </source>
    </evidence>
    <sequence length="46" mass="5493" checksum="E208A726F4877B94" modified="2014-04-16" version="1">MSLVYSKPRTVDDDIGMPLNQPIFTKDKTNFYNYGKLYQNYWQNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W6RRX0</accession>
    <name>W6RRX0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SOSS complex subunit A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ints-3</name>
        <name evidence="11" type="ORF">CELE_Y92H12A.4</name>
        <name evidence="13" type="ORF">Y92H12A.4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368443.1">
        <property type="nucleotide sequence ID" value="NM_001381224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RRX0"/>
    <dbReference type="SMR" id="W6RRX0"/>
    <dbReference type="PeptideAtlas" id="W6RRX0"/>
    <dbReference type="GeneID" id="3565441"/>
    <dbReference type="AGR" id="WB:WBGene00022360"/>
    <dbReference type="CTD" id="3565441"/>
    <dbReference type="WormBase" id="Y92H12A.4d">
        <property type="protein sequence ID" value="CE49509"/>
        <property type="gene ID" value="WBGene00022360"/>
        <property type="gene designation" value="ints-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007659_0_0_1"/>
    <dbReference type="OrthoDB" id="2021145at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022360">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RRX0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056518">
        <property type="entry name" value="HEAT_Ints3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045334">
        <property type="entry name" value="INTS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019333">
        <property type="entry name" value="INTS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587:SF7">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24566">
        <property type="entry name" value="HEAT_Ints3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10189">
        <property type="entry name" value="Ints3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ints3-like C-terminal" evidence="10">
        <location>
            <begin position="202"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="608"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM63511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="Y92H12A.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="W6RRX0"/>
        </source>
    </evidence>
    <sequence length="668" mass="75499" checksum="48EC1368C2365400" modified="2014-04-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>W6RRX6</accession>
    <name>W6RRX6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">sax-7</name>
        <name evidence="11" type="ORF">C18F3.2</name>
        <name evidence="9" type="ORF">CELE_C18F3.2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDM63516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294161.1">
        <property type="nucleotide sequence ID" value="NM_001307232.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6RRX6"/>
    <dbReference type="PeptideAtlas" id="W6RRX6"/>
    <dbReference type="GeneID" id="177602"/>
    <dbReference type="AGR" id="WB:WBGene00004732"/>
    <dbReference type="CTD" id="177602"/>
    <dbReference type="WormBase" id="C18F3.2e">
        <property type="protein sequence ID" value="CE49593"/>
        <property type="gene ID" value="WBGene00004732"/>
        <property type="gene designation" value="sax-7"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096603_0_0_1"/>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004732">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6RRX6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDO41126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="C53B4.4f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="X5LQ14"/>
        </source>
    </evidence>
    <sequence length="1264" mass="140299" checksum="5F33198001EF72E5" modified="2014-06-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>X5LQ22</accession>
    <name>X5LQ22_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F42A9.8</name>
        <name evidence="1 3" type="ORF">F42A9.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDO41136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="X5LQ22"/>
    <dbReference type="AGR" id="WB:WBGene00018337"/>
    <dbReference type="WormBase" id="F42A9.8b">
        <property type="protein sequence ID" value="CE49713"/>
        <property type="gene ID" value="WBGene00018337"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2063604_0_0_1"/>
    <dbReference type="OrthoDB" id="5791056at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018337">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="X5LQ22">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDO41136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F42A9.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="X5LQ22"/>
        </source>
    </evidence>
    <sequence length="62" mass="7076" checksum="BD31DDAD1B1E9C5B" modified="2014-06-11" version="1">MRTVMRGATQNGSRLLDYDSIAEFFANSEFRALKDFFPERVRFDEIESEILPTRATGPSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>X5LQ30</accession>
    <name>X5LQ30_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">egl-30</name>
        <name evidence="12" type="ORF">CELE_M01D7.7</name>
        <name evidence="14" type="ORF">M01D7.7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 11">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDO41146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293357.1">
        <property type="nucleotide sequence ID" value="NM_001306428.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="X5LQ30"/>
    <dbReference type="SMR" id="X5LQ30"/>
    <dbReference type="PeptideAtlas" id="X5LQ30"/>
    <dbReference type="GeneID" id="171751"/>
    <dbReference type="KEGG" id="cel:CELE_M01D7.7"/>
    <dbReference type="AGR" id="WB:WBGene00001196"/>
    <dbReference type="CTD" id="171751"/>
    <dbReference type="WormBase" id="M01D7.7c">
        <property type="protein sequence ID" value="CE49743"/>
        <property type="gene ID" value="WBGene00001196"/>
        <property type="gene designation" value="egl-30"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001196">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="X5LQ30">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000654">
        <property type="entry name" value="Gprotein_alpha_Q"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF365">
        <property type="entry name" value="EGL-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00442">
        <property type="entry name" value="GPROTEINAQ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="27"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDO41146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="M01D7.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="X5LQ30"/>
        </source>
    </evidence>
    <sequence length="112" mass="13153" checksum="E3AB47229FFB5E7A" modified="2014-06-11" version="1">MEESKALFRTIITYPWFTNSSVILFLNKKDLLEEKILYSHLADYFPEYDGPPRDPIAAREFILKMFVDLNPDADKIIYSHFTCATDTENIRFVFAAVKDTILQHNLKEYNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPN3</accession>
    <name>A0A078BPN3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">srv-15</name>
        <name evidence="7" type="ORF">CELE_Y105C5B.6</name>
        <name evidence="9" type="ORF">Y105C5B.6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294119.1">
        <property type="nucleotide sequence ID" value="NM_001307190.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPN3"/>
    <dbReference type="SMR" id="A0A078BPN3"/>
    <dbReference type="GeneID" id="190889"/>
    <dbReference type="AGR" id="WB:WBGene00005726"/>
    <dbReference type="CTD" id="190889"/>
    <dbReference type="WormBase" id="Y105C5B.6d">
        <property type="protein sequence ID" value="CE50037"/>
        <property type="gene ID" value="WBGene00005726"/>
        <property type="gene designation" value="srv-15"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5798218at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005726">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPN3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31748:SF11">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31748">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDX47500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y105C5B.6d"/>
        </source>
    </evidence>
    <sequence length="219" mass="25214" checksum="E140258265362B75" modified="2014-10-29" version="1">MCVSLMATNRVSAILFPNRHSRIWSSTRLRIAIAVQFLPGLLAGLATFFNETQLYRNTKNGLIPRFKRSDSGKRKNFIAVLFVIAGGFLATVCIYLIIAYCYLIFMLRKSSNAIKNTQFHKSRAVIKKKEVKLFFMSSITVAIQISILCLVIVYATSLLNFPLDKFYLFYNAISDLYAGINPYLLWIFSDSLRKHIWHRIGWRRTWKIPTSSVVTVNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H4M8</accession>
    <name>A0A168H4M8_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">Spastin/Vps4 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">figl-1</name>
        <name evidence="4" type="ORF">CELE_F32D1.1</name>
        <name evidence="6" type="ORF">F32D1.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317806.1">
        <property type="nucleotide sequence ID" value="NM_001330856.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H4M8"/>
    <dbReference type="SMR" id="A0A168H4M8"/>
    <dbReference type="GeneID" id="178829"/>
    <dbReference type="AGR" id="WB:WBGene00017981"/>
    <dbReference type="CTD" id="178829"/>
    <dbReference type="WormBase" id="F32D1.1c">
        <property type="protein sequence ID" value="CE51574"/>
        <property type="gene ID" value="WBGene00017981"/>
        <property type="gene designation" value="figl-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017981">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A168H4M8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spastin/Vps4 C-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SAP35566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F32D1.1c"/>
        </source>
    </evidence>
    <sequence length="39" mass="4325" checksum="87F0F7CFCEF4F400" modified="2016-07-06" version="1">MDFAEAARVVRPTVDDSQLDAYAAWDKKFGCLPPPSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H4W1</accession>
    <name>A0A168H4W1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GMP reductase</fullName>
            <ecNumber evidence="1">1.7.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">gmpr-1</name>
        <name evidence="6" type="ORF">CELE_F32D1.5</name>
        <name evidence="8" type="ORF">F32D1.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.1.7" evidence="1"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317809.1">
        <property type="nucleotide sequence ID" value="NM_001330859.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H4W1"/>
    <dbReference type="SMR" id="A0A168H4W1"/>
    <dbReference type="GeneID" id="178834"/>
    <dbReference type="AGR" id="WB:WBGene00017984"/>
    <dbReference type="CTD" id="178834"/>
    <dbReference type="WormBase" id="F32D1.5b">
        <property type="protein sequence ID" value="CE51586"/>
        <property type="gene ID" value="WBGene00017984"/>
        <property type="gene designation" value="gmpr-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017984">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A168H4W1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF5">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SAP35569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F32D1.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A0A168H4W1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9713" checksum="E8D60E1B2ACA66E6" modified="2016-07-06" version="1">MSSDTAMKKHHGSVAEYRASEGKTVTIPYRGDVNGTVQDILGGIRSACTYTGAKHLKELAKRATFIRVTQQTNDMYVPFEVPTVPAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-09-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2X0REA8</accession>
    <name>A0A2X0REA8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">twk-2</name>
        <name evidence="12" type="ORF">CELE_T12C9.3</name>
        <name evidence="14" type="ORF">T12C9.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SPS41580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001350987.1">
        <property type="nucleotide sequence ID" value="NM_001364062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="188452"/>
    <dbReference type="AGR" id="WB:WBGene00006657"/>
    <dbReference type="CTD" id="188452"/>
    <dbReference type="WormBase" id="T12C9.3d">
        <property type="protein sequence ID" value="CE52668"/>
        <property type="gene ID" value="WBGene00006657"/>
        <property type="gene designation" value="twk-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006657">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2X0REA8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF110">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="163"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="286"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="564"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="831"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1179"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="831"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1015"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1179"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SPS41580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T12C9.3d"/>
        </source>
    </evidence>
    <sequence length="1448" mass="165202" checksum="B1E3024B5E06775E" modified="2018-09-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4QFC8</accession>
    <name>A0A8S4QFC8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">wht-7</name>
        <name evidence="11" type="ORF">CELE_Y42G9A.6</name>
        <name evidence="13" type="ORF">Y42G9A.6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAH2176192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001391163.1">
        <property type="nucleotide sequence ID" value="NM_001404163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4QFC8"/>
    <dbReference type="SMR" id="A0A8S4QFC8"/>
    <dbReference type="GeneID" id="175864"/>
    <dbReference type="AGR" id="WB:WBGene00021535"/>
    <dbReference type="CTD" id="175864"/>
    <dbReference type="WormBase" id="Y42G9A.6f">
        <property type="protein sequence ID" value="CE54501"/>
        <property type="gene ID" value="WBGene00021535"/>
        <property type="gene designation" value="wht-7"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="WHiTe (Drosophila) related ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
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            <begin position="606"/>
            <end position="630"/>
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    </feature>
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            <begin position="37"/>
            <end position="278"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH2176192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="Y42G9A.6f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4QFC8"/>
        </source>
    </evidence>
    <sequence length="636" mass="71911" checksum="61781EEB249D7B19" modified="2022-10-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4QFI2</accession>
    <name>A0A8S4QFI2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">igcm-3</name>
        <name evidence="9" type="ORF">CELE_T02C5.3</name>
        <name evidence="11" type="ORF">T02C5.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAH2193563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001391197.1">
        <property type="nucleotide sequence ID" value="NM_001404198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4QFI2"/>
    <dbReference type="GeneID" id="180569"/>
    <dbReference type="AGR" id="WB:WBGene00020160"/>
    <dbReference type="CTD" id="180569"/>
    <dbReference type="WormBase" id="T02C5.3f">
        <property type="protein sequence ID" value="CE54394"/>
        <property type="gene ID" value="WBGene00020160"/>
        <property type="gene designation" value="igcm-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6107927at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277:SF108">
        <property type="entry name" value="FASCICLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
        <property type="entry name" value="NECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="149"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH2193563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="T02C5.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4QFI2"/>
        </source>
    </evidence>
    <sequence length="471" mass="51945" checksum="66C2052326BEA237" modified="2022-10-12" version="1">MCQAALNGGTVDSSPATVDVRYLRQPHVVDSNGQSPVLIGNQGYRFFVECVRGADGLCQQSGRRKTLKCDVQSNPPATQYRWLKNGSPSGTGAEITIGTEMIGQSIQCQANNGLHDESNMPLSQAVQIDPYSSAKLLKDNFQKLQSTSPFLASNRIEMNQQVNMGCEVEGNPRPIVYWRMRKPNGDVVDAACPQGLEGQYQELPPEGGRSANIVRLTALCSLRISNYSYSGQYWCAACSQVSQGEPECSPSLETPGTSSLNVQVIGAPSNSDAPPSIEQRGNDATVLVHYCAEPMPRPPREIVFSIDQNDLQVGQSWENFRFDSAVTNNTVPNCYIARLSISPVREEDQYRRIALKLQNQFGSKQIPVSMDALLGGDSAMVGRMPTFWMYILIGVAALLFVICIIAVCVRRRVKDHPDYNEPKTKANLNIHQENDYFEPPPNAPRLFAQHPPEVNAYDQAVKDAQLRMSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4QFJ4</accession>
    <name>A0A8S4QFJ4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">ekl-5</name>
        <name evidence="2" type="ORF">CELE_Y26E6A.1</name>
        <name evidence="4" type="ORF">Y26E6A.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAH2194081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001391205.1">
        <property type="nucleotide sequence ID" value="NM_001404213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4QFJ4"/>
    <dbReference type="GeneID" id="181500"/>
    <dbReference type="KEGG" id="cel:CELE_Y26E6A.1"/>
    <dbReference type="AGR" id="WB:WBGene00012512"/>
    <dbReference type="CTD" id="181500"/>
    <dbReference type="WormBase" id="Y26E6A.1b">
        <property type="protein sequence ID" value="CE16607"/>
        <property type="gene ID" value="WBGene00012512"/>
        <property type="gene designation" value="ekl-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5887280at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH2194081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y26E6A.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4QFJ4"/>
        </source>
    </evidence>
    <sequence length="449" mass="51880" checksum="067CD3FA63ECBA23" modified="2022-10-12" version="1">MLPVANNPEEQANEEELRDQAADIPQARNHNLRNHARRHREMFERARANRRLQADRGAQAARERGGPAAGRAQLGRARAREALARANNARQALQPDAAVLEALDEINGIDFDDEEVPNRRDVRQDPQVLEFANLFPRLIALDPHDAQLANQNLARMARHLAPENYIRVARREQRQSFMCGICKSSVHNVAFLNHLDTCAASKGACKIMKDMEYHHFLSSTYSLRQQLYKLRERLELEYFEARVNPERLEHMECAGCITCAEHLLGACMPNMQRDVYQIHANKIEKTVMAHFEQFLELTKEDGLGEIISKHTAHFDSIQDCIEDGPTDFETQNRRHGTWYEFRKDTVEEQQLEKNKYLEETIEKHLVKYRSHRTEVTKLIGLFMDKMLACIEELKNSPRLARIIQLRRVHCIDPIRGQVPLEGEAEEIEDDEEDINAVVQAEEFLQLGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>A3RMS7</accession>
    <name>A3RMS7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RRM_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C37H5.13</name>
        <name evidence="2" type="ORF">CELE_C37H5.13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD66995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367644.1">
        <property type="nucleotide sequence ID" value="NM_001380640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3RMS7"/>
    <dbReference type="PeptideAtlas" id="A3RMS7"/>
    <dbReference type="GeneID" id="178878"/>
    <dbReference type="KEGG" id="cel:CELE_C37H5.13"/>
    <dbReference type="UCSC" id="C37H5.13a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016511"/>
    <dbReference type="CTD" id="178878"/>
    <dbReference type="WormBase" id="C37H5.13c">
        <property type="protein sequence ID" value="CE39688"/>
        <property type="gene ID" value="WBGene00016511"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158182_0_0_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016511">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A3RMS7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD66995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C37H5.13c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A3RMS7"/>
        </source>
    </evidence>
    <sequence length="99" mass="11279" checksum="9C4F62FBCF3DDB68" modified="2007-04-03" version="1">MSSPSSTHANTAPVVQSHFAHRPQHVSSAPSRSMEIDDQNGVQHYPMLLNVTHIDMTSRADDIRAGLIDTFLNLERVDKNLYLTYFPPTIEEFFYGWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A9QY31</accession>
    <name>A9QY31_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM GPCR serpentine receptor class x (Srx) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">srx-130</name>
        <name evidence="3" type="ORF">CELE_F09F3.1</name>
        <name evidence="5" type="ORF">F09F3.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAP46772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122904.1">
        <property type="nucleotide sequence ID" value="NM_001129432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9QY31"/>
    <dbReference type="GeneID" id="184249"/>
    <dbReference type="KEGG" id="cel:CELE_F09F3.1"/>
    <dbReference type="UCSC" id="F09F3.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006021"/>
    <dbReference type="CTD" id="184249"/>
    <dbReference type="WormBase" id="F09F3.1b">
        <property type="protein sequence ID" value="CE41890"/>
        <property type="gene ID" value="WBGene00006021"/>
        <property type="gene designation" value="srx-130"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070417_0_0_1"/>
    <dbReference type="OrthoDB" id="5891847at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006021">
        <property type="expression patterns" value="Expressed in adult organism"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A9QY31">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46611:SF1">
        <property type="entry name" value="7TM GPCR SERPENTINE RECEPTOR CLASS X (SRX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46611">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAP46772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F09F3.1b"/>
        </source>
    </evidence>
    <sequence length="108" mass="12713" checksum="2C8CA8442871EDD6" modified="2008-02-05" version="1">MSNSGVNAEESRARRKRWMVNFTQCVIQDSLQLFDTINAYYMWRFYDAAWYRFLFATLSFILVSALDGFVMFIYHQECLKLITLKWKSTTVEPSPVNSLPSGHRTLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQA2</accession>
    <name>D3NQA2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein Rab-44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rabr-2</name>
        <name evidence="5" type="ORF">4R79.2</name>
        <name evidence="3" type="ORF">CELE_4R79.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255967.1">
        <property type="nucleotide sequence ID" value="NM_001269038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQA2"/>
    <dbReference type="SMR" id="D3NQA2"/>
    <dbReference type="PeptideAtlas" id="D3NQA2"/>
    <dbReference type="GeneID" id="181797"/>
    <dbReference type="AGR" id="WB:WBGene00007067"/>
    <dbReference type="CTD" id="181797"/>
    <dbReference type="WormBase" id="4R79.2b">
        <property type="protein sequence ID" value="CE44666"/>
        <property type="gene ID" value="WBGene00007067"/>
        <property type="gene designation" value="rabr-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767750_0_0_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007067">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQA2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001822">
        <property type="entry name" value="RAB family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBK19358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="4R79.2b"/>
        </source>
    </evidence>
    <sequence length="311" mass="35977" checksum="8BFD9D2F83A992B3" modified="2010-04-20" version="1">MAKNEVEIPCILDKSQYLEESSLEDEMREIEQNKSYLDDPLTKILKKELEEIKNYEDFQVRNEQVLDNIIIKKPLYRPIQPEQSIPKVSSLAEELNAIGKKVLQKEEIEEEVTQPDRIFKVVFVGDSAVGKTCFLHRFCHNRFKPLFNATIGVDFTVKTMKIPPNRAIAMQLWDTAGQERFRSITKQYFRKADGVVLMFDVTSEQSFLNVRNWIDSVRAGVDDATVMCLVGNKMDLFGSDIARSAVYRAAEKLAVEFKIPFFETSAYTGFGIDTCMRQMAENLQRREDNHLEEALKLDINSNYKKRSWCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQA6</accession>
    <name>D3NQA6_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_Y105C5A.15</name>
        <name evidence="7 9" type="ORF">Y105C5A.15</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19481.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255877.1">
        <property type="nucleotide sequence ID" value="NM_001268948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQA6"/>
    <dbReference type="SMR" id="D3NQA6"/>
    <dbReference type="GeneID" id="178442"/>
    <dbReference type="AGR" id="WB:WBGene00013639"/>
    <dbReference type="CTD" id="178442"/>
    <dbReference type="WormBase" id="Y105C5A.15a">
        <property type="protein sequence ID" value="CE46279"/>
        <property type="gene ID" value="WBGene00013639"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1607513at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013639">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQA6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF29">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBK19481.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y105C5A.15a"/>
        </source>
    </evidence>
    <sequence length="762" mass="84852" checksum="D36825A075C93DF7" modified="2011-11-16" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQA7</accession>
    <name>D3NQA7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair and recombination protein RAD54-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein okra</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">rad-54.b</name>
        <name evidence="12" type="synonym">rad-54.B</name>
        <name evidence="12" type="ORF">CELE_Y116A8C.13</name>
        <name evidence="14" type="ORF">Y116A8C.13</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts (via N-terminus) with spn-A/Rad51.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255914.1">
        <property type="nucleotide sequence ID" value="NM_001268985.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQA7"/>
    <dbReference type="SMR" id="D3NQA7"/>
    <dbReference type="PeptideAtlas" id="D3NQA7"/>
    <dbReference type="GeneID" id="190999"/>
    <dbReference type="AGR" id="WB:WBGene00013792"/>
    <dbReference type="CTD" id="190999"/>
    <dbReference type="WormBase" id="Y116A8C.13b">
        <property type="protein sequence ID" value="CE44656"/>
        <property type="gene ID" value="WBGene00013792"/>
        <property type="gene designation" value="rad-54.B"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_3_1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013792">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQA7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="112"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="414"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="615"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBK19482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="Y116A8C.13b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="D3NQA7"/>
        </source>
    </evidence>
    <sequence length="720" mass="80752" checksum="DFB67A93C947F8FE" modified="2010-04-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQA8</accession>
    <name>D3NQA8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3800 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y116A8C.27</name>
        <name evidence="1 3" type="ORF">Y116A8C.27</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255921.1">
        <property type="nucleotide sequence ID" value="NM_001268992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQA8"/>
    <dbReference type="SMR" id="D3NQA8"/>
    <dbReference type="PeptideAtlas" id="D3NQA8"/>
    <dbReference type="GeneID" id="191004"/>
    <dbReference type="AGR" id="WB:WBGene00013804"/>
    <dbReference type="CTD" id="191004"/>
    <dbReference type="WormBase" id="Y116A8C.27b">
        <property type="protein sequence ID" value="CE44714"/>
        <property type="gene ID" value="WBGene00013804"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047893_2_0_1"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013804">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQA8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043461">
        <property type="term" value="P:proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y116A8C.27b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="D3NQA8"/>
        </source>
    </evidence>
    <sequence length="181" mass="20707" checksum="E3B27CD6DDFF71B4" modified="2010-04-20" version="1">MRLTGLAFTAQDNPLEQTADTISQKILDYVEGDTVLFFNTESSKLHRYQEEKWAPLIKNLNNDLGIKVRPSENILDCDVASENDKEKIDRWIRQHNFPALVGLQYATESVKSFVIAYNAIRHHIDPDTAIDAATLEQRTQAETWGNVEWAHGIEREELMTRLSAACLFVYFNSNNFTSKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQB0</accession>
    <name>D3NQB0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">bca-2</name>
        <name evidence="1" type="ORF">CELE_Y116A8C.28</name>
        <name evidence="3" type="ORF">Y116A8C.28</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255923.1">
        <property type="nucleotide sequence ID" value="NM_001268994.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQB0"/>
    <dbReference type="SMR" id="D3NQB0"/>
    <dbReference type="PeptideAtlas" id="D3NQB0"/>
    <dbReference type="GeneID" id="178484"/>
    <dbReference type="AGR" id="WB:WBGene00013805"/>
    <dbReference type="CTD" id="178484"/>
    <dbReference type="WormBase" id="Y116A8C.28e">
        <property type="protein sequence ID" value="CE44625"/>
        <property type="gene ID" value="WBGene00013805"/>
        <property type="gene designation" value="bca-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_5_3_1"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013805">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQB0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y116A8C.28e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="D3NQB0"/>
        </source>
    </evidence>
    <sequence length="31" mass="3702" checksum="D7BF450EA423C1EA" modified="2010-04-20" version="1">MHMFSKPNKQFVLVDESNVEELIDEVEKHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQB1</accession>
    <name>D3NQB1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cyn-13</name>
        <name evidence="3" type="ORF">CELE_Y116A8C.34</name>
        <name evidence="5" type="ORF">Y116A8C.34</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255926.1">
        <property type="nucleotide sequence ID" value="NM_001268997.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQB1"/>
    <dbReference type="SMR" id="D3NQB1"/>
    <dbReference type="PeptideAtlas" id="D3NQB1"/>
    <dbReference type="GeneID" id="178487"/>
    <dbReference type="AGR" id="WB:WBGene00000889"/>
    <dbReference type="CTD" id="178487"/>
    <dbReference type="WormBase" id="Y116A8C.34b">
        <property type="protein sequence ID" value="CE23338"/>
        <property type="gene ID" value="WBGene00000889"/>
        <property type="gene designation" value="cyn-13"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_27_0_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000889">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQB1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF575">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBK19486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y116A8C.34b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D3NQB1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11106" checksum="DD353D4E9B3ECA23" modified="2010-04-20" version="1">MPGTVSMANCGANTNGSQFFICTEKTDWLDGKHVVFGHVVEGMNIVRQVEQQGTPSGKPQMVVKIVESGEIEPEKRIAAEKLAQKAVVPGAEIQEPLPQAMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQB3</accession>
    <name>D3NQB3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">General transcription factor IIH subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gtf-2h4</name>
        <name evidence="12" type="synonym">gtf-2H4</name>
        <name evidence="12" type="ORF">CELE_Y73F8A.24</name>
        <name evidence="14" type="ORF">Y73F8A.24</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255864.1">
        <property type="nucleotide sequence ID" value="NM_001268935.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQB3"/>
    <dbReference type="SMR" id="D3NQB3"/>
    <dbReference type="PeptideAtlas" id="D3NQB3"/>
    <dbReference type="GeneID" id="178431"/>
    <dbReference type="AGR" id="WB:WBGene00013529"/>
    <dbReference type="CTD" id="178431"/>
    <dbReference type="WormBase" id="Y73F8A.24b">
        <property type="protein sequence ID" value="CE44553"/>
        <property type="gene ID" value="WBGene00013529"/>
        <property type="gene designation" value="gtf-2H4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027280_4_0_1"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013529">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQB3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="11">
        <location>
            <begin position="345"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBK19514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="Y73F8A.24b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="D3NQB3"/>
        </source>
    </evidence>
    <sequence length="431" mass="49091" checksum="946011034128756F" modified="2010-04-20" version="1">MLPPIAQQTTIQLIWKGSFPTASDVEETKEIEDQVKLLKDLGLVHRQTTDGKLNIDTDYKRSYMYAAMLGAAQISSLVLEPNEGNRRGKDVEKKAVERWDCILRYLALPSEENTQAVSETTRNLFKKANFTSGGDTQIEITTFGFQFLLLSPVKQMWTYVIEYLKLEMSQGQDIVEVIEPLIQIVLLANRGFKAERECYQIDANWTEPQNELLNHLRELGVIFIRKRKDGVFFLTQLLTHLATNETIDDVSAEKVSNGKVIVETNFRVYAYTSSLLQLAIIALFTEMTYRFQDMSVGMITRESVRGALQHGITAAQIISFLRANAHPQCIATSGPVNCLPITVADQIRLWEDERRRMNLKDAYIYSHFESEDEFHGVCEYARQQNILLWSDNQQKLVIVNEDGHELVRQWYKREKSKTGAGGEASSSTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQB4</accession>
    <name>D3NQB4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">ari-1.4</name>
        <name evidence="12" type="ORF">CELE_Y73F8A.34</name>
        <name evidence="14" type="ORF">Y73F8A.34</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255868.1">
        <property type="nucleotide sequence ID" value="NM_001268939.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQB4"/>
    <dbReference type="SMR" id="D3NQB4"/>
    <dbReference type="PeptideAtlas" id="D3NQB4"/>
    <dbReference type="GeneID" id="178437"/>
    <dbReference type="AGR" id="WB:WBGene00013538"/>
    <dbReference type="CTD" id="178437"/>
    <dbReference type="WormBase" id="Y73F8A.34c">
        <property type="protein sequence ID" value="CE44555"/>
        <property type="gene ID" value="WBGene00013538"/>
        <property type="gene designation" value="ari-1.4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009823_4_2_1"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013538">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQB4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="72"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBK19515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="Y73F8A.34c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="D3NQB4"/>
        </source>
    </evidence>
    <sequence length="436" mass="50059" checksum="BB00131202944C41" modified="2010-04-20" version="1">MSKTISEVQAILQVEPGICRILLHKFKWNKDRLLDKFYEHSDTTEFLAEAQVIPKTSSSEEAAGSSAPPPGGDAECDVCCSMTRLSGLACAHRACDECWKAYLTEKIVDVGQSEIECMMMDCKLLIEDEKVMSYITDPFVIAAYRKLIISSYVETNSQLKWCPGAGCGKAVKGEPSDREPAVCTCGERFCFACAQDWHDPLSCRHMKMWRKKCSDDSETLNWINANTKPCPKCSVTIEKNGGCNHMSCKSSSCRYEFCWLCLGDWKNHAQCNRYVEDDNKTDSRSLSRKNLQRYLFYYNRFMAHQNSMKLEGKLYAKVEVKMDLMQALSMSWIEVQFLRRAVDALCECRRTLKYAYAFAYYLEANNMTTLFETNQSDLELATEQLSGMLEGDLEDNDLAELKRKVQDKYRYVELRRKKMLDHCAEGVELDSWVFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQB5</accession>
    <name>D3NQB5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ari-1.4</name>
        <name evidence="11" type="ORF">CELE_Y73F8A.34</name>
        <name evidence="13" type="ORF">Y73F8A.34</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAB60562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255869.1">
        <property type="nucleotide sequence ID" value="NM_001268940.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQB5"/>
    <dbReference type="SMR" id="D3NQB5"/>
    <dbReference type="PeptideAtlas" id="D3NQB5"/>
    <dbReference type="GeneID" id="178437"/>
    <dbReference type="AGR" id="WB:WBGene00013538"/>
    <dbReference type="CTD" id="178437"/>
    <dbReference type="WormBase" id="Y73F8A.34d">
        <property type="protein sequence ID" value="CE24653"/>
        <property type="gene ID" value="WBGene00013538"/>
        <property type="gene designation" value="ari-1.4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009823_4_2_1"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013538">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQB5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB60562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="Y73F8A.34d"/>
        </source>
    </evidence>
    <sequence length="305" mass="35529" checksum="7CB5144530B84D6F" modified="2010-04-20" version="1">MSYITDPFVIAAYRKLIISSYVETNSQLKWCPGAGCGKAVKGEPSDREPAVCTCGERFCFACAQDWHDPLSCRHMKMWRKKCSDDSETLNWINANTKPCPKCSVTIEKNGGCNHMSCKSSSCRYEFCWLCLGDWKNHAQCNRYVEDDNKTDSRSLSRKNLQRYLFYYNRFMAHQNSMKLEGKLYAKVEVKMDLMQALSMSWIEVQFLRRAVDALCECRRTLKYAYAFAYYLEANNMTTLFETNQSDLELATEQLSGMLEGDLEDNDLAELKRKVQDKYRYVELRRKKMLDHCAEGVELDSWVFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQB6</accession>
    <name>D3NQB6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_Y62E10A.13</name>
        <name evidence="10 12" type="ORF">Y62E10A.13</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041052.2">
        <property type="nucleotide sequence ID" value="NM_001047587.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQB6"/>
    <dbReference type="SMR" id="D3NQB6"/>
    <dbReference type="PeptideAtlas" id="D3NQB6"/>
    <dbReference type="GeneID" id="178304"/>
    <dbReference type="KEGG" id="cel:CELE_Y62E10A.13"/>
    <dbReference type="AGR" id="WB:WBGene00013379"/>
    <dbReference type="CTD" id="178304"/>
    <dbReference type="WormBase" id="Y62E10A.13d">
        <property type="protein sequence ID" value="CE44613"/>
        <property type="gene ID" value="WBGene00013379"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036368_2_1_1"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013379">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQB6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000542">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBK19509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y62E10A.13d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="D3NQB6"/>
        </source>
    </evidence>
    <sequence length="66" mass="7326" checksum="A76FCB6F63966CA3" modified="2010-04-20" version="1">MYNYKTVVMVGDGATDVEASPPADAFIGFGGNVIREGVKARAKWYVTDFDVLRKDLDHDESDIDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQB7</accession>
    <name>D3NQB7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serpentine Receptor, class SX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">srsx-25</name>
        <name evidence="6" type="ORF">CELE_Y62E10A.4</name>
        <name evidence="8" type="ORF">Y62E10A.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255733.1">
        <property type="nucleotide sequence ID" value="NM_001268804.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQB7"/>
    <dbReference type="SMR" id="D3NQB7"/>
    <dbReference type="GeneID" id="190453"/>
    <dbReference type="AGR" id="WB:WBGene00013375"/>
    <dbReference type="CTD" id="190453"/>
    <dbReference type="WormBase" id="Y62E10A.4b">
        <property type="protein sequence ID" value="CE44647"/>
        <property type="gene ID" value="WBGene00013375"/>
        <property type="gene designation" value="srsx-25"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087184_0_0_1"/>
    <dbReference type="OrthoDB" id="5863619at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013375">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQB7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047130">
        <property type="entry name" value="7TM_GPCR_Srsx_nematod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360:SF16">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23360">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBK19510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y62E10A.4b"/>
        </source>
    </evidence>
    <sequence length="107" mass="12231" checksum="D2854B814ADB5A43" modified="2010-04-20" version="1">MDAVNRLLKSLSIVVTIYVCTWFLTISSLVVSQLITFSPPVTAEINRQLGWLVIINASLNFFVYLWRNSEYRKAFIRLYGLSRLFSVENTSIDAATRVMKSSHVRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQB9</accession>
    <name>D3NQB9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_Y67H2A.10</name>
        <name evidence="8 10" type="ORF">Y67H2A.10</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255718.1">
        <property type="nucleotide sequence ID" value="NM_001268789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQB9"/>
    <dbReference type="SMR" id="D3NQB9"/>
    <dbReference type="PeptideAtlas" id="D3NQB9"/>
    <dbReference type="GeneID" id="259340"/>
    <dbReference type="KEGG" id="cel:CELE_Y67H2A.10"/>
    <dbReference type="AGR" id="WB:WBGene00013465"/>
    <dbReference type="CTD" id="259340"/>
    <dbReference type="WormBase" id="Y67H2A.10b">
        <property type="protein sequence ID" value="CE44570"/>
        <property type="gene ID" value="WBGene00013465"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863628at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013465">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQB9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <location>
            <begin position="153"/>
            <end position="178"/>
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        <location>
            <begin position="271"/>
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            <begin position="204"/>
            <end position="268"/>
        </location>
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        <location>
            <begin position="317"/>
            <end position="362"/>
        </location>
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        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
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            <begin position="426"/>
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            <end position="215"/>
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        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
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        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
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            <begin position="342"/>
            <end position="362"/>
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            <end position="473"/>
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            <begin position="549"/>
            <end position="561"/>
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            <begin position="568"/>
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            <begin position="585"/>
            <end position="597"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBK19511.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="Y67H2A.10b"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="D3NQB9"/>
        </source>
    </evidence>
    <sequence length="605" mass="68868" checksum="3A6BCEFD8597C416" modified="2010-04-20" version="1"> </sequence>
</entry>
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        <name evidence="2" type="ORF">CELE_Y67H2A.10</name>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="CBK19512.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="Y67H2A.10c"/>
        </source>
    </evidence>
    <sequence length="23" mass="2593" checksum="1819AB1E658E3AC4" modified="2010-04-20" version="1">MMSSPPNNSQQMTPSQQPPPYNM</sequence>
</entry>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C11E4.7b"/>
        </source>
    </evidence>
    <sequence length="343" mass="39121" checksum="2E49EBE0D3F1E99E" modified="2011-10-19" version="1">MSSISSLNTATKITPHISSSSCFLPSFSHQVEENFQKRKIFNEKPQPEKRICMENMSHPVPSIPIISAPSIQQTKHPKHVFNDWMNFFSSFNGAVNLKLDDGTKGNNFYYQFHLQLAQYYQDKMCMEGVIQLGKPFKLEETSDADRMNIITTSVASTYKAMYDKEIERLTLENKNMADKIRTQHATSIYLFPGIAYGRNPSEDSPEVIDHLMFEIIYKGFMEVTPEKDTNNFGKQVHGVLTSINCKTRNECSTRVSMMTVSNSEIVVQIPFTSRIKISNILAVGKYGEDRNYFCIAYHNSKTVEHVKIIVFCTHSCFTSSDIVNSIIRKTAINKGREALMIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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    <dbReference type="AlphaFoldDB" id="G1K0Y0"/>
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    <dbReference type="AGR" id="WB:WBGene00008832"/>
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    <dbReference type="WormBase" id="F14H8.1c">
        <property type="protein sequence ID" value="CE46315"/>
        <property type="gene ID" value="WBGene00008832"/>
        <property type="gene designation" value="obr-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007105_6_2_1"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008832">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCC42169.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="G1K0Y0"/>
        </source>
    </evidence>
    <sequence length="264" mass="30580" checksum="36B875B5B8C9446B" modified="2011-10-19" version="1">MTKLLANPHAHLKLTFKKTGETYSWSAPKCAIYNVIMGKMYMNFTSHMKIESSGTYDAVFSFDNKGYYNHKGGDVHVEGHIFEGKNKIKALYGNWTLFLASCDNEDFKHHRKEYLRMFNETVSEKDQGPVVPGSKILWVSNQIPKLFDDQFHFTNFTLSLNEMYPGMSDTVAPTDSRRRKDMKALEDGKNDEAEEFKHKYEEEQRERRTTKTGDVPMWFAKNDEGHWAYKGGYWDRDYSNCLELFESLENSSTNSSNSSISSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0Y1</accession>
    <name>G1K0Y1_CAEEL</name>
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        <submittedName>
            <fullName evidence="5">DOCKER domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_F22G12.5</name>
        <name evidence="5 7" type="ORF">F22G12.5</name>
    </gene>
    <organism evidence="5 6">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCC42170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001252089.1">
        <property type="nucleotide sequence ID" value="NM_001265160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0Y1"/>
    <dbReference type="SMR" id="G1K0Y1"/>
    <dbReference type="PeptideAtlas" id="G1K0Y1"/>
    <dbReference type="GeneID" id="173181"/>
    <dbReference type="AGR" id="WB:WBGene00009065"/>
    <dbReference type="CTD" id="173181"/>
    <dbReference type="WormBase" id="F22G12.5b">
        <property type="protein sequence ID" value="CE46442"/>
        <property type="gene ID" value="WBGene00009065"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000624_1_0_1"/>
    <dbReference type="OrthoDB" id="47328at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009065">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0Y1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
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        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF26">
        <property type="entry name" value="ZIZIMIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="4">
        <location>
            <begin position="791"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC42170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F22G12.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="G1K0Y1"/>
        </source>
    </evidence>
    <sequence length="1267" mass="141571" checksum="7152B12E4E210BA0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0Y6</accession>
    <name>G1K0Y6_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F20E11.18</name>
        <name evidence="2 4" type="ORF">F20E11.18</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCC42172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256743.1">
        <property type="nucleotide sequence ID" value="NM_001269814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0Y6"/>
    <dbReference type="GeneID" id="13217856"/>
    <dbReference type="KEGG" id="cel:CELE_F20E11.18"/>
    <dbReference type="AGR" id="WB:WBGene00206495"/>
    <dbReference type="CTD" id="13217856"/>
    <dbReference type="WormBase" id="F20E11.18b">
        <property type="protein sequence ID" value="CE46472"/>
        <property type="gene ID" value="WBGene00206495"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2123286_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0Y6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003412886" evidence="1">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC42172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F20E11.18b"/>
        </source>
    </evidence>
    <sequence length="108" mass="11645" checksum="3570D11AA1E46717" modified="2011-10-19" version="1">MHFVVYILVLVACAPIIGFSQMYDDGSYSSHEDGAVKGIVQDAENTLTDGLSKILPQGSNHEHQLQNRPQLYEGGVGNGILQEGILRDGFVEGGILNKGKNGRDYIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0Y8</accession>
    <name>G1K0Y8_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">B0250.18</name>
        <name evidence="1" type="ORF">CELE_B0250.18</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCC42178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294678.1">
        <property type="nucleotide sequence ID" value="NM_001307749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0Y8"/>
    <dbReference type="GeneID" id="13218813"/>
    <dbReference type="AGR" id="WB:WBGene00206505"/>
    <dbReference type="CTD" id="13218813"/>
    <dbReference type="WormBase" id="B0250.18b">
        <property type="protein sequence ID" value="CE46126"/>
        <property type="gene ID" value="WBGene00206505"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3426978_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00206505">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0Y8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC42178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="B0250.18b"/>
        </source>
    </evidence>
    <sequence length="21" mass="2322" checksum="051DD042117FAE72" modified="2011-10-19" version="1">MNLIGMRKVTQINLCGSTDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0Z6</accession>
    <name>G1K0Z6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C08F11.13</name>
        <name evidence="2" type="ORF">CELE_C08F11.13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCC42150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379532.1">
        <property type="nucleotide sequence ID" value="NM_001392434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0Z6"/>
    <dbReference type="GeneID" id="178327"/>
    <dbReference type="AGR" id="WB:WBGene00007460"/>
    <dbReference type="CTD" id="178327"/>
    <dbReference type="WormBase" id="C08F11.13b">
        <property type="protein sequence ID" value="CE46121"/>
        <property type="gene ID" value="WBGene00007460"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1929467_0_0_1"/>
    <dbReference type="OrthoDB" id="5908928at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007460">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0Z6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC42150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C08F11.13b"/>
        </source>
    </evidence>
    <sequence length="131" mass="14992" checksum="27E6B6FEA0EF3729" modified="2011-10-19" version="1">MSEKCGSKFFETGDEKQNLDGQNGDYAPGKIELLLKKLNPILISFSTYPLYILILIIASESELLSNIVPIPLILGLFATFELFDLLLLNPPRRYKNGLQLETIVLPEEDDFNEFKGKIRRIEIFHCFTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0Z7</accession>
    <name>G1K0Z7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C08F11.13</name>
        <name evidence="2" type="ORF">CELE_C08F11.13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCC42151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359766.1">
        <property type="nucleotide sequence ID" value="NM_001372955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0Z7"/>
    <dbReference type="GeneID" id="178327"/>
    <dbReference type="AGR" id="WB:WBGene00007460"/>
    <dbReference type="CTD" id="178327"/>
    <dbReference type="WormBase" id="C08F11.13c">
        <property type="protein sequence ID" value="CE46232"/>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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                <person name="Waterston R."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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            <strain evidence="4">Bristol N2</strain>
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        <citation type="journal article" date="2000" name="J. Mol. Neurosci." volume="15" first="231" last="241">
            <title>The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans.</title>
            <authorList>
                <person name="Kiehl T.R."/>
                <person name="Shibata H."/>
                <person name="Pulst S.M."/>
            </authorList>
            <dbReference type="PubMed" id="11303786"/>
            <dbReference type="DOI" id="10.1385/JMN:15:3:231"/>
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        <citation type="journal article" date="2004" name="Development" volume="131" first="4831" last="4841">
            <title>ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline.</title>
            <authorList>
                <person name="Ciosk R."/>
                <person name="DePalma M."/>
                <person name="Priess J.R."/>
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            <dbReference type="PubMed" id="15342467"/>
            <dbReference type="DOI" id="10.1242/dev.01352"/>
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        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="3" key="4">
        <citation type="journal article" date="2004" name="Genetics" volume="168" first="817" last="830">
            <title>Caenorhabditis elegans atx-2 promotes germline proliferation and the oocyte fate.</title>
            <authorList>
                <person name="Maine E.M."/>
                <person name="Hansen D."/>
                <person name="Springer D."/>
                <person name="Vought V.E."/>
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            <dbReference type="PubMed" id="15514056"/>
            <dbReference type="DOI" id="10.1534/genetics.104.029355"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006370" last="E1006370">
            <title>ATX-2, the C. elegans ortholog of human Ataxin-2, regulates centrosome size and microtubule dynamics.</title>
            <authorList>
                <person name="Stubenvoll M.D."/>
                <person name="Medley J.C."/>
                <person name="Irwin M."/>
                <person name="Song M.H."/>
            </authorList>
            <dbReference type="PubMed" id="27689799"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006370"/>
        </citation>
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        <scope>INTERACTION WITH SZY-20</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2016" name="Proc. Natl. Acad. Sci. U.S.A." volume="113" first="E4620" last="E4629">
            <title>Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor.</title>
            <authorList>
                <person name="Bar D.Z."/>
                <person name="Charar C."/>
                <person name="Dorfman J."/>
                <person name="Yadid T."/>
                <person name="Tafforeau L."/>
                <person name="Lafontaine D.L."/>
                <person name="Gruenbaum Y."/>
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            <dbReference type="PubMed" id="27457958"/>
            <dbReference type="DOI" id="10.1073/pnas.1512156113"/>
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        <scope>INTERACTION WITH GDI-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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        <isoform>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2000" name="J. Mol. Neurosci." volume="15" first="231" last="241">
            <title>The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans.</title>
            <authorList>
                <person name="Kiehl T.R."/>
                <person name="Shibata H."/>
                <person name="Pulst S.M."/>
            </authorList>
            <dbReference type="PubMed" id="11303786"/>
            <dbReference type="DOI" id="10.1385/JMN:15:3:231"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2004" name="Development" volume="131" first="4831" last="4841">
            <title>ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline.</title>
            <authorList>
                <person name="Ciosk R."/>
                <person name="DePalma M."/>
                <person name="Priess J.R."/>
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            <dbReference type="PubMed" id="15342467"/>
            <dbReference type="DOI" id="10.1242/dev.01352"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PAB-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="3" key="4">
        <citation type="journal article" date="2004" name="Genetics" volume="168" first="817" last="830">
            <title>Caenorhabditis elegans atx-2 promotes germline proliferation and the oocyte fate.</title>
            <authorList>
                <person name="Maine E.M."/>
                <person name="Hansen D."/>
                <person name="Springer D."/>
                <person name="Vought V.E."/>
            </authorList>
            <dbReference type="PubMed" id="15514056"/>
            <dbReference type="DOI" id="10.1534/genetics.104.029355"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006370" last="E1006370">
            <title>ATX-2, the C. elegans ortholog of human Ataxin-2, regulates centrosome size and microtubule dynamics.</title>
            <authorList>
                <person name="Stubenvoll M.D."/>
                <person name="Medley J.C."/>
                <person name="Irwin M."/>
                <person name="Song M.H."/>
            </authorList>
            <dbReference type="PubMed" id="27689799"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006370"/>
        </citation>
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        <scope>INTERACTION WITH SZY-20</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2016" name="Proc. Natl. Acad. Sci. U.S.A." volume="113" first="E4620" last="E4629">
            <title>Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor.</title>
            <authorList>
                <person name="Bar D.Z."/>
                <person name="Charar C."/>
                <person name="Dorfman J."/>
                <person name="Yadid T."/>
                <person name="Tafforeau L."/>
                <person name="Lafontaine D.L."/>
                <person name="Gruenbaum Y."/>
            </authorList>
            <dbReference type="PubMed" id="27457958"/>
            <dbReference type="DOI" id="10.1073/pnas.1512156113"/>
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        <scope>SUBCELLULAR LOCATION</scope>
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        <source>
            <dbReference type="WormBase" id="D2045.1a"/>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bristol N2</strain>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2005" name="J. Gen. Physiol." volume="125" first="113" last="125">
            <title>GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel.</title>
            <authorList>
                <person name="Denton J."/>
                <person name="Nehrke K."/>
                <person name="Yin X."/>
                <person name="Morrison R."/>
                <person name="Strange K."/>
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            <dbReference type="PubMed" id="15684092"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CLH-3</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Choe K.P."/>
                <person name="Strange K."/>
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            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH WNK-1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="4" key="4">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="70" last="75">
            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH WNK-1</scope>
        <scope>PHOSPHORYLATION AT THR-280 AND SER-419</scope>
        <scope>MUTAGENESIS OF THR-280 AND SER-419</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2010" name="Dev. Biol." volume="344" first="758" last="771">
            <title>The Caenorhabditis elegans Ste20 kinase, GCK-3, is essential for postembryonic developmental timing and regulates meiotic chromosome segregation.</title>
            <authorList>
                <person name="Kupinski A.P."/>
                <person name="Muller-Reichert T."/>
                <person name="Eckmann C.R."/>
            </authorList>
            <dbReference type="PubMed" id="20595048"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.05.505"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PHOSPHORYLATION AT THR-13; THR-32; SER-190 AND SER-405</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>MUTAGENESIS OF LYS-137</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
            <authorList>
                <person name="Lee E.C."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EEN4-3</id>
            <name evidence="9">c</name>
            <sequence type="described" ref="VSP_057537 VSP_057538"/>
        </isoform>
        <isoform>
            <id>G5EEN4-2</id>
            <name evidence="8">b</name>
            <sequence type="described" ref="VSP_057536"/>
        </isoform>
        <isoform>
            <id>G5EEN4-1</id>
            <name evidence="7">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 2"/>
    <dbReference type="RefSeq" id="NP_001129918.1">
        <property type="nucleotide sequence ID" value="NM_001136446.4"/>
    </dbReference>
    <dbReference type="WormBase" id="Y59A8B.23b">
        <property type="protein sequence ID" value="CE43021"/>
        <property type="gene ID" value="WBGene00013355"/>
        <property type="gene designation" value="gck-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="20595048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="15684092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="AAU89102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y59A8B.23a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y59A8B.23b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="Y59A8B.23c"/>
        </source>
    </evidence>
    <sequence length="439" mass="48146" checksum="6BDFA9E06F4DE48F" modified="2011-12-14" version="1">MSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFFKKGKDKKYLVHTLIENLASVPVVAHHSSKKVASGKLRKDAHGNWEFEYDSPQESDDDSDLEDEEREKKKKKASASASGAGAAGAAGGATGGAASGAPSAQEGGGATTPCPETLNMVLRVRNQQRELNDIKFDYTKSADTVEGIAHELVTAELIDCHDLVIVAANLQKLIDFAESKSDRRSITFALNSGVHANEIPDERTLTGFAQISLLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-04-01" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>G5EEN4-3</accession>
    <name>GCK3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform c of Germinal center kinase 3</fullName>
            <ecNumber evidence="1 2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">STE20-like serine/threonine kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gck-3</name>
        <name evidence="7" type="ORF">Y59A8B.23</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2005" name="J. Gen. Physiol." volume="125" first="113" last="125">
            <title>GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel.</title>
            <authorList>
                <person name="Denton J."/>
                <person name="Nehrke K."/>
                <person name="Yin X."/>
                <person name="Morrison R."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="15684092"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CLH-3</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2007" name="Am. J. Physiol." volume="293" first="C915" last="927">
            <title>Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Choe K.P."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="17596296"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00126.2007"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH WNK-1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="70" last="75">
            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="18049475"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INTERACTION WITH WNK-1</scope>
        <scope>PHOSPHORYLATION AT THR-280 AND SER-419</scope>
        <scope>MUTAGENESIS OF THR-280 AND SER-419</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2010" name="Dev. Biol." volume="344" first="758" last="771">
            <title>The Caenorhabditis elegans Ste20 kinase, GCK-3, is essential for postembryonic developmental timing and regulates meiotic chromosome segregation.</title>
            <authorList>
                <person name="Kupinski A.P."/>
                <person name="Muller-Reichert T."/>
                <person name="Eckmann C.R."/>
            </authorList>
            <dbReference type="PubMed" id="20595048"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.05.505"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PHOSPHORYLATION AT THR-13; THR-32; SER-190 AND SER-405</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>MUTAGENESIS OF LYS-137</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
            <authorList>
                <person name="Lee E.C."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EEN4-2</id>
            <name evidence="8">b</name>
            <sequence type="described" ref="VSP_057536"/>
        </isoform>
        <isoform>
            <id>G5EEN4-1</id>
            <name evidence="7">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EEN4-3</id>
            <name evidence="9">c</name>
            <sequence type="described" ref="VSP_057538 VSP_057537"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 2"/>
    <dbReference type="RefSeq" id="NP_001379534.1">
        <property type="nucleotide sequence ID" value="NM_001392687.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y59A8B.23c">
        <property type="protein sequence ID" value="CE46529"/>
        <property type="gene ID" value="WBGene00013355"/>
        <property type="gene designation" value="gck-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="20595048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="15684092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="AAU89102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y59A8B.23a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y59A8B.23b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="Y59A8B.23c"/>
        </source>
    </evidence>
    <sequence length="541" mass="58231" checksum="5BEC80D9197AA723" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESD1</accession>
    <name>H8ESD1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1330 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_H04D03.2</name>
        <name evidence="2 4" type="ORF">H04D03.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCG28193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_499303.2">
        <property type="nucleotide sequence ID" value="NM_066902.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESD1"/>
    <dbReference type="SMR" id="H8ESD1"/>
    <dbReference type="GeneID" id="186678"/>
    <dbReference type="KEGG" id="cel:CELE_H04D03.2"/>
    <dbReference type="AGR" id="WB:WBGene00010363"/>
    <dbReference type="CTD" id="186678"/>
    <dbReference type="WormBase" id="H04D03.2b">
        <property type="protein sequence ID" value="CE47327"/>
        <property type="gene ID" value="WBGene00010363"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432957_0_0_1"/>
    <dbReference type="OrthoDB" id="10635500at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010363">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESD1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="H04D03.2b"/>
        </source>
    </evidence>
    <sequence length="115" mass="12981" checksum="8445FC59B949E078" modified="2012-05-16" version="1">MAQKSMSPAPQSIETPSPIAPEPAAEFLIYQKTIDDTGDIVKYYRELEKPPISFHENGLSFVREGDKMELKLVNKPREMIREETGPPEIPHRGSTPPPICNGNARRTRFASVRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESD2</accession>
    <name>H8ESD2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y2H9A.4</name>
        <name evidence="3 5" type="ORF">Y2H9A.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256506.1">
        <property type="nucleotide sequence ID" value="NM_001269577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESD2"/>
    <dbReference type="SMR" id="H8ESD2"/>
    <dbReference type="GeneID" id="189352"/>
    <dbReference type="AGR" id="WB:WBGene00012381"/>
    <dbReference type="CTD" id="189352"/>
    <dbReference type="WormBase" id="Y2H9A.4c">
        <property type="protein sequence ID" value="CE47268"/>
        <property type="gene ID" value="WBGene00012381"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877453at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012381">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESD2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007883">
        <property type="entry name" value="DUF713"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21566">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251-LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21566:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05218">
        <property type="entry name" value="DUF713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCG28070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y2H9A.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="H8ESD2"/>
        </source>
    </evidence>
    <sequence length="597" mass="69051" checksum="B5E38362CDE3C8BA" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESD4</accession>
    <name>H8ESD4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 12 member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">nkcc-1</name>
        <name evidence="9" type="ORF">CELE_Y37A1C.1</name>
        <name evidence="11" type="ORF">Y37A1C.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255791.1">
        <property type="nucleotide sequence ID" value="NM_001268862.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESD4"/>
    <dbReference type="SMR" id="H8ESD4"/>
    <dbReference type="GeneID" id="3565648"/>
    <dbReference type="AGR" id="WB:WBGene00012543"/>
    <dbReference type="CTD" id="3565648"/>
    <dbReference type="WormBase" id="Y37A1C.1f">
        <property type="protein sequence ID" value="CE47205"/>
        <property type="gene ID" value="WBGene00012543"/>
        <property type="gene designation" value="nkcc-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012543">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESD4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015377">
        <property type="term" value="F:chloride:monoatomic cation symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000022">
        <property type="entry name" value="Bumetanide-sensitive na-k-cl cotransport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="643"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="225"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="8">
        <location>
            <begin position="727"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="879"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="900"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCG28055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y37A1C.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="H8ESD4"/>
        </source>
    </evidence>
    <sequence length="1186" mass="131931" checksum="54738CE82963C92F" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESD6</accession>
    <name>H8ESD6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 24" type="primary">slo-1</name>
        <name evidence="22" type="ORF">CELE_Y51A2D.19</name>
        <name evidence="24" type="ORF">Y51A2D.19</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256801.1">
        <property type="nucleotide sequence ID" value="NM_001269872.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESD6"/>
    <dbReference type="SMR" id="H8ESD6"/>
    <dbReference type="GeneID" id="180203"/>
    <dbReference type="AGR" id="WB:WBGene00004830"/>
    <dbReference type="CTD" id="180203"/>
    <dbReference type="WormBase" id="Y51A2D.19m">
        <property type="protein sequence ID" value="CE47416"/>
        <property type="gene ID" value="WBGene00004830"/>
        <property type="gene designation" value="slo-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004830">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESD6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000035">
        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="386"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="805"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCG28223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WormBase" id="Y51A2D.19m"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PeptideAtlas" id="H8ESD6"/>
        </source>
    </evidence>
    <sequence length="1146" mass="130490" checksum="5FD43F988B35EB7D" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESD8</accession>
    <name>H8ESD8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 24" type="primary">slo-1</name>
        <name evidence="22" type="ORF">CELE_Y51A2D.19</name>
        <name evidence="24" type="ORF">Y51A2D.19</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256808.1">
        <property type="nucleotide sequence ID" value="NM_001269879.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESD8"/>
    <dbReference type="SMR" id="H8ESD8"/>
    <dbReference type="GeneID" id="180203"/>
    <dbReference type="AGR" id="WB:WBGene00004830"/>
    <dbReference type="CTD" id="180203"/>
    <dbReference type="WormBase" id="Y51A2D.19k">
        <property type="protein sequence ID" value="CE47333"/>
        <property type="gene ID" value="WBGene00004830"/>
        <property type="gene designation" value="slo-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004830">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESD8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="P:response to xenobiotic stimulus"/>
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        <property type="project" value="WormBase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
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    </dbReference>
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        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="371"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="797"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCG28225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WormBase" id="Y51A2D.19k"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PeptideAtlas" id="H8ESD8"/>
        </source>
    </evidence>
    <sequence length="1138" mass="129399" checksum="9BB92DB9C2A2A9FE" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESE2</accession>
    <name>H8ESE2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 24" type="primary">slo-1</name>
        <name evidence="22" type="ORF">CELE_Y51A2D.19</name>
        <name evidence="24" type="ORF">Y51A2D.19</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256807.1">
        <property type="nucleotide sequence ID" value="NM_001269878.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESE2"/>
    <dbReference type="SMR" id="H8ESE2"/>
    <dbReference type="GeneID" id="180203"/>
    <dbReference type="AGR" id="WB:WBGene00004830"/>
    <dbReference type="CTD" id="180203"/>
    <dbReference type="WormBase" id="Y51A2D.19i">
        <property type="protein sequence ID" value="CE47162"/>
        <property type="gene ID" value="WBGene00004830"/>
        <property type="gene designation" value="slo-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004830">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESE2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000035">
        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="371"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="819"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCG28229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WormBase" id="Y51A2D.19i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PeptideAtlas" id="H8ESE2"/>
        </source>
    </evidence>
    <sequence length="1160" mass="131895" checksum="4DB05CA327440DB7" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESE3</accession>
    <name>H8ESE3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 24" type="primary">slo-1</name>
        <name evidence="22" type="ORF">CELE_Y51A2D.19</name>
        <name evidence="24" type="ORF">Y51A2D.19</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256809.1">
        <property type="nucleotide sequence ID" value="NM_001269880.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESE3"/>
    <dbReference type="SMR" id="H8ESE3"/>
    <dbReference type="GeneID" id="180203"/>
    <dbReference type="AGR" id="WB:WBGene00004830"/>
    <dbReference type="CTD" id="180203"/>
    <dbReference type="WormBase" id="Y51A2D.19j">
        <property type="protein sequence ID" value="CE47368"/>
        <property type="gene ID" value="WBGene00004830"/>
        <property type="gene designation" value="slo-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004830">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESE3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000035">
        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="371"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="812"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCG28230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WormBase" id="Y51A2D.19j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PeptideAtlas" id="H8ESE3"/>
        </source>
    </evidence>
    <sequence length="1153" mass="131125" checksum="D4ED41EEA1B1B86E" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESE4</accession>
    <name>H8ESE4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 24" type="primary">slo-1</name>
        <name evidence="22" type="ORF">CELE_Y51A2D.19</name>
        <name evidence="24" type="ORF">Y51A2D.19</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256803.1">
        <property type="nucleotide sequence ID" value="NM_001269874.3"/>
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    <dbReference type="AlphaFoldDB" id="H8ESE4"/>
    <dbReference type="SMR" id="H8ESE4"/>
    <dbReference type="GeneID" id="180203"/>
    <dbReference type="AGR" id="WB:WBGene00004830"/>
    <dbReference type="CTD" id="180203"/>
    <dbReference type="WormBase" id="Y51A2D.19g">
        <property type="protein sequence ID" value="CE47078"/>
        <property type="gene ID" value="WBGene00004830"/>
        <property type="gene designation" value="slo-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004830">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESE4">
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    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="371"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="797"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCG28231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WormBase" id="Y51A2D.19g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PeptideAtlas" id="H8ESE4"/>
        </source>
    </evidence>
    <sequence length="1138" mass="129403" checksum="A1F890CBD48D3C9C" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESE5</accession>
    <name>H8ESE5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 24" type="primary">slo-1</name>
        <name evidence="22" type="ORF">CELE_Y51A2D.19</name>
        <name evidence="24" type="ORF">Y51A2D.19</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256805.1">
        <property type="nucleotide sequence ID" value="NM_001269876.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESE5"/>
    <dbReference type="SMR" id="H8ESE5"/>
    <dbReference type="GeneID" id="180203"/>
    <dbReference type="AGR" id="WB:WBGene00004830"/>
    <dbReference type="CTD" id="180203"/>
    <dbReference type="WormBase" id="Y51A2D.19f">
        <property type="protein sequence ID" value="CE47218"/>
        <property type="gene ID" value="WBGene00004830"/>
        <property type="gene designation" value="slo-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004830">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESE5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048149">
        <property type="term" value="P:behavioral response to ethanol"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="P:sarcomere organization"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="371"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="21">
        <location>
            <begin position="799"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CCG28232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WormBase" id="Y51A2D.19f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PeptideAtlas" id="H8ESE5"/>
        </source>
    </evidence>
    <sequence length="1140" mass="129534" checksum="D14E56F373D2E23D" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESE6</accession>
    <name>H8ESE6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nhr-68</name>
        <name evidence="5" type="ORF">CELE_H12C20.3</name>
        <name evidence="7" type="ORF">H12C20.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368113.1">
        <property type="nucleotide sequence ID" value="NM_001380770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESE6"/>
    <dbReference type="SMR" id="H8ESE6"/>
    <dbReference type="PeptideAtlas" id="H8ESE6"/>
    <dbReference type="GeneID" id="179589"/>
    <dbReference type="AGR" id="WB:WBGene00003658"/>
    <dbReference type="CTD" id="179589"/>
    <dbReference type="WormBase" id="H12C20.3b">
        <property type="protein sequence ID" value="CE47189"/>
        <property type="gene ID" value="WBGene00003658"/>
        <property type="gene designation" value="nhr-68"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007368_3_3_1"/>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003658">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESE6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCG28060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="H12C20.3b"/>
        </source>
    </evidence>
    <sequence length="103" mass="11812" checksum="0DC7D9E143B0A813" modified="2012-05-16" version="1">MEINFNEFAAFKAITFLNPDADISLESKHAINEERVLITKQLYAYMVQKDGLEKAIYRFGRLILMGTSMSKMACESKEAVWIADFFENIGFTSFAKELIFGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESE9</accession>
    <name>H8ESE9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y11D7A.10</name>
        <name evidence="1 3" type="ORF">Y11D7A.10</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255382.1">
        <property type="nucleotide sequence ID" value="NM_001268453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESE9"/>
    <dbReference type="SMR" id="H8ESE9"/>
    <dbReference type="PeptideAtlas" id="H8ESE9"/>
    <dbReference type="GeneID" id="177747"/>
    <dbReference type="AGR" id="WB:WBGene00012434"/>
    <dbReference type="CTD" id="177747"/>
    <dbReference type="WormBase" id="Y11D7A.10c">
        <property type="protein sequence ID" value="CE47321"/>
        <property type="gene ID" value="WBGene00012434"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_204805_0_0_1"/>
    <dbReference type="OrthoDB" id="5833121at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012434">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESE9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y11D7A.10c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H8ESE9"/>
        </source>
    </evidence>
    <sequence length="51" mass="6028" checksum="63C2012982F56C02" modified="2012-05-16" version="1">MHVAYYTIQNNPSLVAPHQRQELFYVRWLKEKIPALRPYGVTDDKTPKADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESF0</accession>
    <name>H8ESF0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Complex I-B8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y11D7A.10</name>
        <name evidence="1 3" type="ORF">Y11D7A.10</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255381.1">
        <property type="nucleotide sequence ID" value="NM_001268452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESF0"/>
    <dbReference type="GeneID" id="177747"/>
    <dbReference type="AGR" id="WB:WBGene00012434"/>
    <dbReference type="CTD" id="177747"/>
    <dbReference type="WormBase" id="Y11D7A.10d">
        <property type="protein sequence ID" value="CE47158"/>
        <property type="gene ID" value="WBGene00012434"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5833121at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012434">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESF0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCG28178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y11D7A.10d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H8ESF0"/>
        </source>
    </evidence>
    <sequence length="68" mass="8072" checksum="786871FF60F7516B" modified="2012-05-16" version="1">MVVFRTFSELNHNYFSAMHVAYYTIQNNPSLVAPHQRQELFYVRWLKEKIPALRPYGVTDDKTPKADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESF4</accession>
    <name>H8ESF4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SANT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">swsn-1</name>
        <name evidence="11" type="ORF">CELE_Y113G7B.23</name>
        <name evidence="13" type="ORF">Y113G7B.23</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMARCC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCG28100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256908.1">
        <property type="nucleotide sequence ID" value="NM_001269979.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESF4"/>
    <dbReference type="SMR" id="H8ESF4"/>
    <dbReference type="PeptideAtlas" id="H8ESF4"/>
    <dbReference type="GeneID" id="180324"/>
    <dbReference type="AGR" id="WB:WBGene00004203"/>
    <dbReference type="CTD" id="180324"/>
    <dbReference type="WormBase" id="Y113G7B.23b">
        <property type="protein sequence ID" value="CE47143"/>
        <property type="gene ID" value="WBGene00004203"/>
        <property type="gene designation" value="swsn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004203">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESF4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035262">
        <property type="term" value="P:gonad morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040027">
        <property type="term" value="P:negative regulation of vulval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040010">
        <property type="term" value="P:positive regulation of growth rate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046662">
        <property type="term" value="P:regulation of egg-laying behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50090"/>
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        <source>
            <dbReference type="PROSITE" id="PS51293"/>
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        <source>
            <dbReference type="EMBL" id="CCG28100.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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        <source>
            <dbReference type="WormBase" id="Y113G7B.23b"/>
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    <sequence length="685" mass="73968" checksum="A9CCE96B5B8573F3" modified="2012-05-16" version="1"> </sequence>
</entry>
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    <accession>H8ESF5</accession>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">Bristol N2</strain>
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        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
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        </source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="H8ESF5"/>
        </source>
    </evidence>
    <sequence length="263" mass="29235" checksum="FE0B9B7AFBF0A826" modified="2012-05-16" version="1">MEKAADQHPWFGMEQEYTLLDIDGHPFGWPKNGFPGPQGPYYCGVGANKVYGRDIVEAHYRACLYAGIQISGTNAEVMPGQWEFQVGPCEGIQMGDQLWVARYLLQRVAEEFGVIASFDCKPIKGDWNGAGCHTNFSTDKMRNPGGIDEIMSAINKLSLVHPQHIAYYDPHGGKDNERRLTGLHETASIDKFSYGVASRASSIRIPRSTDDDGYGYFEDRRPSSNCDPYTVTGALVRTVCLEGAERKLSMMYVPSQAPNITKH</sequence>
</entry>
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    <accession>H8ESF6</accession>
    <name>H8ESF6_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">CELE_Y79H2A.3</name>
        <name evidence="2 4" type="ORF">Y79H2A.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCG28285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255159.1">
        <property type="nucleotide sequence ID" value="NM_001268230.1"/>
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    <dbReference type="AGR" id="WB:WBGene00013580"/>
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        <property type="protein sequence ID" value="CE47352"/>
        <property type="gene ID" value="WBGene00013580"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877502at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013580">
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF132">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="905"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28285.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y79H2A.3c"/>
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    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="1086" mass="125413" checksum="283FB0BDBB7F58F3" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
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        <property type="protein sequence ID" value="CAB61084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254462.1">
        <property type="nucleotide sequence ID" value="NM_001267533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESH7"/>
    <dbReference type="SMR" id="H8ESH7"/>
    <dbReference type="PeptideAtlas" id="H8ESH7"/>
    <dbReference type="GeneID" id="175157"/>
    <dbReference type="AGR" id="WB:WBGene00013161"/>
    <dbReference type="CTD" id="175157"/>
    <dbReference type="WormBase" id="Y53F4B.14b">
        <property type="protein sequence ID" value="CE22403"/>
        <property type="gene ID" value="WBGene00013161"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2442845_0_0_1"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013161">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESH7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y53F4B.14b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="H8ESH7"/>
        </source>
    </evidence>
    <sequence length="56" mass="6495" checksum="DB2FF0C1D5339A8B" modified="2012-05-16" version="1">MRGYRIPDSSAGDKAMAEFKEQLLATKRKEEYENFLREQMAFEEAKKIRGAAANRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESI2</accession>
    <name>H8ESI2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y67H2A.2</name>
        <name evidence="2 4" type="ORF">Y67H2A.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESI2"/>
    <dbReference type="AGR" id="WB:WBGene00013461"/>
    <dbReference type="WormBase" id="Y67H2A.2d">
        <property type="protein sequence ID" value="CE47455"/>
        <property type="gene ID" value="WBGene00013461"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1409979_0_0_1"/>
    <dbReference type="OrthoDB" id="7676067at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013461">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESI2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y67H2A.2d"/>
        </source>
    </evidence>
    <sequence length="193" mass="21972" checksum="96EDEA3DBD45503C" modified="2012-05-16" version="1">MNVSGSLATFLQSSGERMAELNSANQKLTELDKIQWERRDMTGTAVILETRKPNLNSVMEAMSMLMFHRMTIGNCQIGSEIDKIKDIFQIVHQPEQEPARRRPRVQIRQRPQVNIEAAAPIGNIQRRLQLIFDQLFAGDEGAVGDEEEEEEYSGDDDSGEETDSEDDDDDRGRFGAVEQQLQIARNNEEMNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H8ESI3</accession>
    <name>H8ESI3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y67H2A.2</name>
        <name evidence="2 4" type="ORF">Y67H2A.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCG28242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8ESI3"/>
    <dbReference type="SMR" id="H8ESI3"/>
    <dbReference type="AGR" id="WB:WBGene00013461"/>
    <dbReference type="WormBase" id="Y67H2A.2c">
        <property type="protein sequence ID" value="CE47477"/>
        <property type="gene ID" value="WBGene00013461"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492785_0_0_1"/>
    <dbReference type="OrthoDB" id="7676067at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013461">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8ESI3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y67H2A.2c"/>
        </source>
    </evidence>
    <sequence length="210" mass="24431" checksum="B39AE783CF1AC8A9" modified="2012-05-16" version="1">MLTFGGVHGIRGNAPRNNILLSSWIGVPRLQRFAIESLRLSFPHKFSGLYCGNLRANQVPEIYSIFYKLGKVEEKERQIIERFQIKFHEREDRTRYFLNSNSGEYVFRHQPEQEPARRRPRVQIRQRPQVNIEAAAPIGNIQRRLQLIFDQLFAGDEGAVGDEEEEEEYSGDDDSGEETDSEDDDDDRGRFGAVEQQLQIARNNEEMNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-07-01" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>O01659</accession>
    <name>O01659_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Vacuolar protein sorting-associated protein 13D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_T28F2.2</name>
        <name evidence="1 3" type="ORF">T28F2.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD68361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T15139">
        <property type="entry name" value="T15139"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O01659"/>
    <dbReference type="SMR" id="O01659"/>
    <dbReference type="PeptideAtlas" id="O01659"/>
    <dbReference type="UCSC" id="T28F2.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020901"/>
    <dbReference type="WormBase" id="T28F2.2a">
        <property type="protein sequence ID" value="CE31075"/>
        <property type="gene ID" value="WBGene00020901"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1526585_0_0_1"/>
    <dbReference type="OrthoDB" id="284322at2759"/>
    <dbReference type="PhylomeDB" id="O01659"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020901">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O01659">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD68361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="T28F2.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="O01659"/>
        </source>
    </evidence>
    <sequence length="175" mass="19654" checksum="1ABA1669368D95FA" modified="2002-10-01" version="2">MECPSWLLEEICTNFSNLTVLKFKELCNRASHLVLCGHDKPILSDTSEGINSVNNHTNLVLIGNWLLLKPAGYDCPSTDLEKEVVQLGLPPEHGIQLRKVYENYKSELREKVCSSVYREPHATIIDASPSSITFQADTQMYDVSMSGSMMNQLKNDVENALSKMKDFAETLPMTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>O18229-2</accession>
    <name>6PGL_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Putative 6-phosphogluconolactonase</fullName>
            <shortName>6PGL</shortName>
            <ecNumber>3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y57G11C.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>A Tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans.</title>
            <authorList>
                <person name="Manage K.I."/>
                <person name="Rogers A.K."/>
                <person name="Wallis D.C."/>
                <person name="Uebel C.J."/>
                <person name="Anderson D.C."/>
                <person name="Nguyen D.A.H."/>
                <person name="Arca K."/>
                <person name="Brown K.C."/>
                <person name="Cordeiro Rodrigues R.J."/>
                <person name="de Albuquerque B.F.M."/>
                <person name="Ketting R.F."/>
                <person name="Montgomery T.A."/>
                <person name="Phillips C.M."/>
            </authorList>
            <dbReference type="PubMed" id="32338603"/>
            <dbReference type="DOI" id="10.7554/elife.56731"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O18229-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_020096"/>
        </isoform>
        <isoform>
            <id>O18229-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.1.31"/>
    <dbReference type="RefSeq" id="NP_001367136.1">
        <property type="nucleotide sequence ID" value="NM_001380535.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y57G11C.3b">
        <property type="protein sequence ID" value="CE14930"/>
        <property type="gene ID" value="WBGene00013301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="Y57G11C.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="Y57G11C.3b"/>
        </source>
    </evidence>
    <sequence length="257" mass="29075" checksum="40A593793C9F5BA1" modified="2001-07-11" version="2">MKPALNVSGDEKELILQLRRYLEEKLTYLLDQNGTVSIGVSGGSMPRVFSKAILSLPQEQLNWKRIRIFMVDERNVDLDSEESNQGEYLRLFPNELRDVFVPMQIFKDPCLTAQHYEISLRKYLLPEQLNNTARFDILFLGVGPDGHTASIFPGKERLEKITELNWVSVITDSPKPPPSRITLTLQTLQHAKNVAFIICGKQKAEIVRGICDRDQKYPAAQARPFNDKLTLFLDEDAATGVPDRDSSDSDSPPPFDG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2026-01-28" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>P24585-2</accession>
    <name>DEG1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform Short of Degenerin deg-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Degeneration of certain neurons protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">deg-1</name>
        <name evidence="1" type="ORF">C47C12.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Nature" volume="345" first="410" last="416">
            <title>The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chalfie M."/>
                <person name="Wolinsky E."/>
            </authorList>
            <dbReference type="PubMed" id="2342572"/>
            <dbReference type="DOI" id="10.1038/345410a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 485-778 (ISOFORM LONG)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Curr. Biol." volume="5" first="441" last="448">
            <title>Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain.</title>
            <authorList>
                <person name="Garcia-Anoveros J."/>
                <person name="Ma C."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="7627559"/>
            <dbReference type="DOI" id="10.1016/S0960-9822(95)00085-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>MUTAGENESIS OF ALA-393; ALA-707; GLY-710 AND SER-720</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P24585-2</id>
            <name>Short</name>
            <sequence type="described" ref="VSP_006198"/>
        </isoform>
        <isoform>
            <id>P24585-1</id>
            <name>Long</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="C47C12.6a"/>
        </source>
    </evidence>
    <sequence length="754" mass="85403" checksum="B8264B4E8E197C76" modified="1996-10-01" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>P34552-4</accession>
    <name>ALXA_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform d of Apoptosis-linked gene 2-interacting protein X 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Prion-like-(Q/N-rich) domain-bearing protein 58</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Protein YNK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">alx-1</name>
        <name type="synonym">pqn-58</name>
        <name type="ORF">R10E12.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Biochim. Biophys. Acta" volume="1354" first="231" last="240">
            <title>Molecular cloning of a splice variant of Caenorhabditis elegans YNK1, a putative element in signal transduction.</title>
            <authorList>
                <person name="Che S."/>
                <person name="Weil M.M."/>
                <person name="Etkin L.D."/>
                <person name="Epstein H.F."/>
                <person name="Kuang J."/>
            </authorList>
            <dbReference type="PubMed" id="9427532"/>
            <dbReference type="DOI" id="10.1016/S0167-4781(97)00112-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Development" volume="132" first="5081" last="5092">
            <title>LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shaye D.D."/>
                <person name="Greenwald I."/>
            </authorList>
            <dbReference type="PubMed" id="16236769"/>
            <dbReference type="DOI" id="10.1242/dev.02076"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34552-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34552-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_016613"/>
        </isoform>
        <isoform>
            <id>P34552-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_016612"/>
        </isoform>
        <isoform>
            <id>P34552-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_016611"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022715.1">
        <property type="nucleotide sequence ID" value="NM_001027544.3"/>
    </dbReference>
    <dbReference type="WormBase" id="R10E12.1d">
        <property type="protein sequence ID" value="CE34084"/>
        <property type="gene ID" value="WBGene00007010"/>
        <property type="gene designation" value="alx-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="498" mass="55166" checksum="7B098D5B5F599A2D" modified="2005-12-20" version="3">MATFGFLSAPLKSTNEVDLVKPLTSYIDNVYNTSDNNRSDVAEAVQELNKLRSKACCQPLDKHQSALDVLTRYYDQLVAIENKIIISATQNPVVFKWKDAFDKGSLFSSRASLSLSDGSFERAAVLFNIGSLMSQIGAAQQFHTDDEIKVSAKLFQQSAGVFARLRDVVLGMVQQEPTPDLMPDTLAALSALMTAQAQEAIYIKGHKDKMKATSMVKISAQVAEFYSEAQKMMSKDIVRGLWDKDWSAIVSGKNLAYQALAQYHQSEVCGEARQIGEQLSRLAESLKLFDTAQKYLPRDITGIWDIYPSVSKAHAAAKKDNDFIYHEKVSDFRTLPTLPKAVLAKPTPMQTPMTPSFRGTNAAQSPANAPPRPPPPRPAAPSVESPIPPPRTQQSMQATPGAPPQYNPYQQQQQPQMQQFQQHPGYYQQPMPYGQPQPMFQPQYQPTFAAPYPTFPGAFPSYQQQWPQQQQQGGFPPNPQFGQQNQQQGGGGGANPFQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>P34624-2</accession>
    <name>CCNY_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Cyclin-Y</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cyy-1</name>
        <name evidence="2" type="ORF">ZK353.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Cell" volume="141" first="846" last="858">
            <title>Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components.</title>
            <authorList>
                <person name="Ou C.Y."/>
                <person name="Poon V.Y."/>
                <person name="Maeder C.I."/>
                <person name="Watanabe S."/>
                <person name="Lehrman E.K."/>
                <person name="Fu A.K."/>
                <person name="Park M."/>
                <person name="Fu W.Y."/>
                <person name="Jorgensen E.M."/>
                <person name="Ip N.Y."/>
                <person name="Shen K."/>
            </authorList>
            <dbReference type="PubMed" id="20510931"/>
            <dbReference type="DOI" id="10.1016/j.cell.2010.04.011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PCT-1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Neuron" volume="70" first="742" last="757">
            <title>CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits.</title>
            <authorList>
                <person name="Park M."/>
                <person name="Watanabe S."/>
                <person name="Poon V.Y."/>
                <person name="Ou C.Y."/>
                <person name="Jorgensen E.M."/>
                <person name="Shen K."/>
            </authorList>
            <dbReference type="PubMed" id="21609829"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2011.04.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34624-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_002453"/>
        </isoform>
        <isoform>
            <id>P34624-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_498858.2">
        <property type="nucleotide sequence ID" value="NM_066457.6"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK353.1a">
        <property type="protein sequence ID" value="CE34452"/>
        <property type="gene ID" value="WBGene00022697"/>
        <property type="gene designation" value="cyy-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1">
        <source>
            <dbReference type="PubMed" id="20510931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="ZK353.1b"/>
        </source>
    </evidence>
    <sequence length="355" mass="41232" checksum="347320D3F72B049C" modified="2003-11-14" version="3">MGNSSCCLRTRSSSGEDKSYNNDGQYIRTNQVEYVNQVFPRDETSTNFLPHISEREVTEGYEEDPSTNPTARPTFMERSKSEMKLKDNRRSCYMLDALAAGGHHPGILPRSLRKSSSCSTIYIDDSTVSQPHLKNTIKCISLAIYYHISNRKNRGHERLMEIFEERLHPIFRDPIPPEQMTRDPDHRNIYRFVRNLFSSAQLTAECAIITLVYIERLLNYAEMDLCPSNWRRVVLGSIMLASKVWDDQAVWNVDYCQILRDTNVDDMNELERRFLECLDFNIEVPSSVYAKYYFDLRTLALANDLQLPIQPLYKERAQRLEALSRVFEDKIQSSSLPKRARSAEHLVFEHPAVLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="204" xmlns="https://uniprot.org/uniprot">
    <accession>P51559-6</accession>
    <name>BLI4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Endoprotease bli-4</fullName>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Blisterase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Blistered cuticle protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bli-4</name>
        <name type="synonym">kpc-4</name>
        <name type="ORF">K04F10.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Genes Dev." volume="9" first="956" last="971">
            <title>The bli-4 locus of Caenorhabditis elegans encodes structurally distinct kex2/subtilisin-like endoproteases essential for early development and adult morphology.</title>
            <authorList>
                <person name="Thacker C."/>
                <person name="Peters K.W."/>
                <person name="Srayko M."/>
                <person name="Rose A.M."/>
            </authorList>
            <dbReference type="PubMed" id="7774813"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Gene" volume="252" first="15" last="25">
            <title>Mutational analysis of bli-4/kpc-4 reveals critical residues required for proprotein convertase function in C. elegans.</title>
            <authorList>
                <person name="Thacker C."/>
                <person name="Srayko M."/>
                <person name="Rose A.M."/>
            </authorList>
            <dbReference type="PubMed" id="10903434"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(00)00211-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>MUTAGENESIS OF HIS-127; GLY-307; PRO-313; GLY-341; GLU-378 AND SER-415</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="Mol. Biochem. Parasitol." volume="169" first="1" last="11">
            <title>The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes.</title>
            <authorList>
                <person name="Stepek G."/>
                <person name="McCormack G."/>
                <person name="Page A.P."/>
            </authorList>
            <dbReference type="PubMed" id="19716386"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2009.08.005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Nat. Neurosci." volume="16" first="1461" last="1467">
            <title>Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Leinwand S.G."/>
                <person name="Chalasani S.H."/>
            </authorList>
            <dbReference type="PubMed" id="24013594"/>
            <dbReference type="DOI" id="10.1038/nn.3511"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2023" name="PLoS Genet." volume="19" first="e1010944" last="e1010944">
            <title>The proprotein convertase BLI-4 promotes collagen secretion prior to assembly of the Caenorhabditis elegans cuticle.</title>
            <authorList>
                <person name="Birnbaum S.K."/>
                <person name="Cohen J.D."/>
                <person name="Belfi A."/>
                <person name="Murray J.I."/>
                <person name="Adams J.R.G."/>
                <person name="Chisholm A.D."/>
                <person name="Sundaram M.V."/>
            </authorList>
            <dbReference type="PubMed" id="37721936"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1010944"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in cuticle biosynthesis but dispensable for larval development.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P51559-15</id>
            <name evidence="9">d</name>
            <name evidence="5">D</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P51559-6</id>
            <name evidence="6">a</name>
            <name evidence="5">A</name>
            <sequence type="described" ref="VSP_058866 VSP_058863"/>
        </isoform>
        <isoform>
            <id>P51559-13</id>
            <name evidence="14">i</name>
            <sequence type="described" ref="VSP_058868 VSP_058861"/>
        </isoform>
        <isoform>
            <id>P51559-9</id>
            <name evidence="10">e</name>
            <sequence type="described" ref="VSP_058869 VSP_058860"/>
        </isoform>
        <isoform>
            <id>P51559-10</id>
            <name evidence="11">f</name>
            <sequence type="described" ref="VSP_058864 VSP_058865"/>
        </isoform>
        <isoform>
            <id>P51559-11</id>
            <name evidence="12">g</name>
            <sequence type="described" ref="VSP_058871 VSP_058858"/>
        </isoform>
        <isoform>
            <id>P51559-14</id>
            <name evidence="15">j</name>
            <sequence type="described" ref="VSP_058867 VSP_058862"/>
        </isoform>
        <isoform>
            <id>P51559-7</id>
            <name evidence="7">b</name>
            <name evidence="5">B</name>
            <sequence type="described" ref="VSP_058870 VSP_058859"/>
        </isoform>
        <isoform>
            <id>P51559-8</id>
            <name evidence="8">c</name>
            <name evidence="5">C</name>
            <sequence type="described" ref="VSP_058873 VSP_058874"/>
        </isoform>
        <isoform>
            <id>P51559-12</id>
            <name evidence="13">h</name>
            <sequence type="described" ref="VSP_058857 VSP_058872"/>
        </isoform>
    </comment>
    <comment type="tissue specificity">
        <text evidence="2">Expressed primarily in the germline.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="RefSeq" id="NP_001021540.1">
        <property type="nucleotide sequence ID" value="NM_001026369.7"/>
    </dbReference>
    <dbReference type="WormBase" id="K04F10.4a">
        <property type="protein sequence ID" value="CE11728"/>
        <property type="gene ID" value="WBGene00000254"/>
        <property type="gene designation" value="bli-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="10903434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="37721936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="7774813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="24013594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="7774813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="K04F10.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K04F10.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="K04F10.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="K04F10.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="K04F10.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="K04F10.4f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="K04F10.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="K04F10.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="K04F10.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="K04F10.4j"/>
        </source>
    </evidence>
    <sequence length="670" mass="73896" checksum="9BE756ACC83F3565" modified="2017-04-12" version="3" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="204" xmlns="https://uniprot.org/uniprot">
    <accession>P51559-7</accession>
    <name>BLI4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Endoprotease bli-4</fullName>
            <ecNumber evidence="1">3.4.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Blisterase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Blistered cuticle protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bli-4</name>
        <name type="synonym">kpc-4</name>
        <name type="ORF">K04F10.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Genes Dev." volume="9" first="956" last="971">
            <title>The bli-4 locus of Caenorhabditis elegans encodes structurally distinct kex2/subtilisin-like endoproteases essential for early development and adult morphology.</title>
            <authorList>
                <person name="Thacker C."/>
                <person name="Peters K.W."/>
                <person name="Srayko M."/>
                <person name="Rose A.M."/>
            </authorList>
            <dbReference type="PubMed" id="7774813"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Gene" volume="252" first="15" last="25">
            <title>Mutational analysis of bli-4/kpc-4 reveals critical residues required for proprotein convertase function in C. elegans.</title>
            <authorList>
                <person name="Thacker C."/>
                <person name="Srayko M."/>
                <person name="Rose A.M."/>
            </authorList>
            <dbReference type="PubMed" id="10903434"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(00)00211-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>MUTAGENESIS OF HIS-127; GLY-307; PRO-313; GLY-341; GLU-378 AND SER-415</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="Mol. Biochem. Parasitol." volume="169" first="1" last="11">
            <title>The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes.</title>
            <authorList>
                <person name="Stepek G."/>
                <person name="McCormack G."/>
                <person name="Page A.P."/>
            </authorList>
            <dbReference type="PubMed" id="19716386"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2009.08.005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Nat. Neurosci." volume="16" first="1461" last="1467">
            <title>Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Leinwand S.G."/>
                <person name="Chalasani S.H."/>
            </authorList>
            <dbReference type="PubMed" id="24013594"/>
            <dbReference type="DOI" id="10.1038/nn.3511"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2023" name="PLoS Genet." volume="19" first="e1010944" last="e1010944">
            <title>The proprotein convertase BLI-4 promotes collagen secretion prior to assembly of the Caenorhabditis elegans cuticle.</title>
            <authorList>
                <person name="Birnbaum S.K."/>
                <person name="Cohen J.D."/>
                <person name="Belfi A."/>
                <person name="Murray J.I."/>
                <person name="Adams J.R.G."/>
                <person name="Chisholm A.D."/>
                <person name="Sundaram M.V."/>
            </authorList>
            <dbReference type="PubMed" id="37721936"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1010944"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P51559-15</id>
            <name evidence="6">d</name>
            <name evidence="2">D</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P51559-10</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_058865 VSP_058864"/>
        </isoform>
        <isoform>
            <id>P51559-7</id>
            <name evidence="4">b</name>
            <name evidence="2">B</name>
            <sequence type="described" ref="VSP_058859 VSP_058870"/>
        </isoform>
        <isoform>
            <id>P51559-6</id>
            <name evidence="3">a</name>
            <name evidence="2">A</name>
            <sequence type="described" ref="VSP_058866 VSP_058863"/>
        </isoform>
        <isoform>
            <id>P51559-12</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_058872 VSP_058857"/>
        </isoform>
        <isoform>
            <id>P51559-14</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_058862 VSP_058867"/>
        </isoform>
        <isoform>
            <id>P51559-11</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_058871 VSP_058858"/>
        </isoform>
        <isoform>
            <id>P51559-9</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_058860 VSP_058869"/>
        </isoform>
        <isoform>
            <id>P51559-8</id>
            <name evidence="5">c</name>
            <name evidence="2">C</name>
            <sequence type="described" ref="VSP_058874 VSP_058873"/>
        </isoform>
        <isoform>
            <id>P51559-13</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_058861 VSP_058868"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001367785.1">
        <property type="nucleotide sequence ID" value="NM_001380518.3"/>
    </dbReference>
    <dbReference type="WormBase" id="K04F10.4b">
        <property type="protein sequence ID" value="CE11730"/>
        <property type="gene ID" value="WBGene00000254"/>
        <property type="gene designation" value="bli-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="24013594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="7774813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="K04F10.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="K04F10.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="K04F10.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="K04F10.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K04F10.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="K04F10.4f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="K04F10.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="K04F10.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="K04F10.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="K04F10.4j"/>
        </source>
    </evidence>
    <sequence length="730" mass="81303" checksum="F71E48017F872214" modified="2017-04-12" version="3" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="204" xmlns="https://uniprot.org/uniprot">
    <accession>P51559-8</accession>
    <name>BLI4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Endoprotease bli-4</fullName>
            <ecNumber evidence="1">3.4.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Blisterase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Blistered cuticle protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bli-4</name>
        <name type="synonym">kpc-4</name>
        <name type="ORF">K04F10.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Genes Dev." volume="9" first="956" last="971">
            <title>The bli-4 locus of Caenorhabditis elegans encodes structurally distinct kex2/subtilisin-like endoproteases essential for early development and adult morphology.</title>
            <authorList>
                <person name="Thacker C."/>
                <person name="Peters K.W."/>
                <person name="Srayko M."/>
                <person name="Rose A.M."/>
            </authorList>
            <dbReference type="PubMed" id="7774813"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Gene" volume="252" first="15" last="25">
            <title>Mutational analysis of bli-4/kpc-4 reveals critical residues required for proprotein convertase function in C. elegans.</title>
            <authorList>
                <person name="Thacker C."/>
                <person name="Srayko M."/>
                <person name="Rose A.M."/>
            </authorList>
            <dbReference type="PubMed" id="10903434"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(00)00211-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>MUTAGENESIS OF HIS-127; GLY-307; PRO-313; GLY-341; GLU-378 AND SER-415</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="Mol. Biochem. Parasitol." volume="169" first="1" last="11">
            <title>The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes.</title>
            <authorList>
                <person name="Stepek G."/>
                <person name="McCormack G."/>
                <person name="Page A.P."/>
            </authorList>
            <dbReference type="PubMed" id="19716386"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2009.08.005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Nat. Neurosci." volume="16" first="1461" last="1467">
            <title>Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Leinwand S.G."/>
                <person name="Chalasani S.H."/>
            </authorList>
            <dbReference type="PubMed" id="24013594"/>
            <dbReference type="DOI" id="10.1038/nn.3511"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2023" name="PLoS Genet." volume="19" first="e1010944" last="e1010944">
            <title>The proprotein convertase BLI-4 promotes collagen secretion prior to assembly of the Caenorhabditis elegans cuticle.</title>
            <authorList>
                <person name="Birnbaum S.K."/>
                <person name="Cohen J.D."/>
                <person name="Belfi A."/>
                <person name="Murray J.I."/>
                <person name="Adams J.R.G."/>
                <person name="Chisholm A.D."/>
                <person name="Sundaram M.V."/>
            </authorList>
            <dbReference type="PubMed" id="37721936"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1010944"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P51559-6</id>
            <name evidence="3">a</name>
            <name evidence="2">A</name>
            <sequence type="described" ref="VSP_058863 VSP_058866"/>
        </isoform>
        <isoform>
            <id>P51559-15</id>
            <name evidence="6">d</name>
            <name evidence="2">D</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P51559-14</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_058862 VSP_058867"/>
        </isoform>
        <isoform>
            <id>P51559-13</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_058868 VSP_058861"/>
        </isoform>
        <isoform>
            <id>P51559-9</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_058860 VSP_058869"/>
        </isoform>
        <isoform>
            <id>P51559-12</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_058857 VSP_058872"/>
        </isoform>
        <isoform>
            <id>P51559-10</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_058865 VSP_058864"/>
        </isoform>
        <isoform>
            <id>P51559-8</id>
            <name evidence="5">c</name>
            <name evidence="2">C</name>
            <sequence type="described" ref="VSP_058874 VSP_058873"/>
        </isoform>
        <isoform>
            <id>P51559-11</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_058871 VSP_058858"/>
        </isoform>
        <isoform>
            <id>P51559-7</id>
            <name evidence="4">b</name>
            <name evidence="2">B</name>
            <sequence type="described" ref="VSP_058859 VSP_058870"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001367786.1">
        <property type="nucleotide sequence ID" value="NM_001380517.2"/>
    </dbReference>
    <dbReference type="WormBase" id="K04F10.4c">
        <property type="protein sequence ID" value="CE11732"/>
        <property type="gene ID" value="WBGene00000254"/>
        <property type="gene designation" value="bli-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="24013594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="7774813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="K04F10.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="K04F10.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="K04F10.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="K04F10.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K04F10.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="K04F10.4f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="K04F10.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="K04F10.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="K04F10.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="K04F10.4j"/>
        </source>
    </evidence>
    <sequence length="827" mass="91177" checksum="AE25AC5832466CA8" modified="2017-04-12" version="3" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="204" xmlns="https://uniprot.org/uniprot">
    <accession>P51559-9</accession>
    <name>BLI4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform e of Endoprotease bli-4</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Blisterase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Blistered cuticle protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bli-4</name>
        <name type="synonym">kpc-4</name>
        <name type="ORF">K04F10.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Genes Dev." volume="9" first="956" last="971">
            <title>The bli-4 locus of Caenorhabditis elegans encodes structurally distinct kex2/subtilisin-like endoproteases essential for early development and adult morphology.</title>
            <authorList>
                <person name="Thacker C."/>
                <person name="Peters K.W."/>
                <person name="Srayko M."/>
                <person name="Rose A.M."/>
            </authorList>
            <dbReference type="PubMed" id="7774813"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Gene" volume="252" first="15" last="25">
            <title>Mutational analysis of bli-4/kpc-4 reveals critical residues required for proprotein convertase function in C. elegans.</title>
            <authorList>
                <person name="Thacker C."/>
                <person name="Srayko M."/>
                <person name="Rose A.M."/>
            </authorList>
            <dbReference type="PubMed" id="10903434"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(00)00211-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>MUTAGENESIS OF HIS-127; GLY-307; PRO-313; GLY-341; GLU-378 AND SER-415</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="Mol. Biochem. Parasitol." volume="169" first="1" last="11">
            <title>The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes.</title>
            <authorList>
                <person name="Stepek G."/>
                <person name="McCormack G."/>
                <person name="Page A.P."/>
            </authorList>
            <dbReference type="PubMed" id="19716386"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2009.08.005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Nat. Neurosci." volume="16" first="1461" last="1467">
            <title>Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Leinwand S.G."/>
                <person name="Chalasani S.H."/>
            </authorList>
            <dbReference type="PubMed" id="24013594"/>
            <dbReference type="DOI" id="10.1038/nn.3511"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2023" name="PLoS Genet." volume="19" first="e1010944" last="e1010944">
            <title>The proprotein convertase BLI-4 promotes collagen secretion prior to assembly of the Caenorhabditis elegans cuticle.</title>
            <authorList>
                <person name="Birnbaum S.K."/>
                <person name="Cohen J.D."/>
                <person name="Belfi A."/>
                <person name="Murray J.I."/>
                <person name="Adams J.R.G."/>
                <person name="Chisholm A.D."/>
                <person name="Sundaram M.V."/>
            </authorList>
            <dbReference type="PubMed" id="37721936"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1010944"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2">Involved in cuticle biosynthesis but dispensable for larval development.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P51559-8</id>
            <name evidence="7">c</name>
            <name evidence="4">C</name>
            <sequence type="described" ref="VSP_058874 VSP_058873"/>
        </isoform>
        <isoform>
            <id>P51559-14</id>
            <name evidence="14">j</name>
            <sequence type="described" ref="VSP_058867 VSP_058862"/>
        </isoform>
        <isoform>
            <id>P51559-6</id>
            <name evidence="5">a</name>
            <name evidence="4">A</name>
            <sequence type="described" ref="VSP_058866 VSP_058863"/>
        </isoform>
        <isoform>
            <id>P51559-10</id>
            <name evidence="10">f</name>
            <sequence type="described" ref="VSP_058865 VSP_058864"/>
        </isoform>
        <isoform>
            <id>P51559-11</id>
            <name evidence="11">g</name>
            <sequence type="described" ref="VSP_058858 VSP_058871"/>
        </isoform>
        <isoform>
            <id>P51559-7</id>
            <name evidence="6">b</name>
            <name evidence="4">B</name>
            <sequence type="described" ref="VSP_058859 VSP_058870"/>
        </isoform>
        <isoform>
            <id>P51559-13</id>
            <name evidence="13">i</name>
            <sequence type="described" ref="VSP_058868 VSP_058861"/>
        </isoform>
        <isoform>
            <id>P51559-15</id>
            <name evidence="8">d</name>
            <name evidence="4">D</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P51559-12</id>
            <name evidence="12">h</name>
            <sequence type="described" ref="VSP_058857 VSP_058872"/>
        </isoform>
        <isoform>
            <id>P51559-9</id>
            <name evidence="9">e</name>
            <sequence type="described" ref="VSP_058860 VSP_058869"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="RefSeq" id="NP_001367787.1">
        <property type="nucleotide sequence ID" value="NM_001380523.1"/>
    </dbReference>
    <dbReference type="WormBase" id="K04F10.4e">
        <property type="protein sequence ID" value="CE51144"/>
        <property type="gene ID" value="WBGene00000254"/>
        <property type="gene designation" value="bli-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="10903434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="7774813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="24013594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="7774813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="K04F10.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="K04F10.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K04F10.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="K04F10.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="K04F10.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="K04F10.4f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="K04F10.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="K04F10.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="K04F10.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="K04F10.4j"/>
        </source>
    </evidence>
    <sequence length="724" mass="80363" checksum="174822BDA2B8EC2B" modified="2017-04-12" version="3" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>P90754-2</accession>
    <name>ENPP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">enpp-1</name>
        <name evidence="1" type="ORF">C27A7.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="667" last="672">
            <title>Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Saito H."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Hirabayashi J."/>
                <person name="Kasai K."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="12754521"/>
            <dbReference type="DOI" id="10.1038/nbt829"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-424</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-424 AND ASN-649</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P90754-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020299"/>
        </isoform>
        <isoform>
            <id>P90754-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="RefSeq" id="NP_001041086.1">
        <property type="nucleotide sequence ID" value="NM_001047621.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C27A7.1b">
        <property type="protein sequence ID" value="CE39478"/>
        <property type="gene ID" value="WBGene00007753"/>
        <property type="gene designation" value="enpp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="C27A7.1a"/>
        </source>
    </evidence>
    <sequence length="824" mass="92521" checksum="461CE3079728C515" modified="1997-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1997-05-01" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>P90902</accession>
    <name>P90902_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">gfi-2</name>
        <name evidence="4" type="ORF">CELE_K02A11.1</name>
        <name evidence="6" type="ORF">K02A11.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAA99881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T23213">
        <property type="entry name" value="T23213"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001366793.1">
        <property type="nucleotide sequence ID" value="NM_001381136.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P90902"/>
    <dbReference type="SMR" id="P90902"/>
    <dbReference type="PeptideAtlas" id="P90902"/>
    <dbReference type="GeneID" id="172825"/>
    <dbReference type="UCSC" id="K02A11.1b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001582"/>
    <dbReference type="CTD" id="172825"/>
    <dbReference type="WormBase" id="K02A11.1a">
        <property type="protein sequence ID" value="CE11616"/>
        <property type="gene ID" value="WBGene00001582"/>
        <property type="gene designation" value="gfi-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001582">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="P90902">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF29">
        <property type="entry name" value="LD46604P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA99881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="K02A11.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="P90902"/>
        </source>
    </evidence>
    <sequence length="476" mass="53687" checksum="A869509038F18CF3" modified="1997-05-01" version="1">MDHSELIAELPEIERMTAQERIALARDRRRLQLRRNDERERALPPPRPRRQRLHFAAEVELLEATCRADYAEVERLLNDNANPNLHNDDGLTPLHQCAIDDNQQIMLLLLERGANVNAQDTEQWTPLHAAACCAHINIVKILIQAGANLLAVNAEGNMPYDICDHEETLDVIESEMAARGITQSYIDEMRGAPEKAMLDDMKMLHQQGRELDARAPDGSTYLHVASANGYYDVAAFLLTCSVSPLIRDNDFWQPVHAAACWAQPDLIELLCQYGGDIHAKTKNGETPMDLCEDMSTKQVISQLVQTEARRRRLAFGVRDSRRQSKKRKKFESPQQGATTGDNPFSARGAIRRQSLRDRSGLTPARIEAQKEGADILRTWSKEDVSADVHSSQGSLQHQRESPSKRVLKSSQNKQAKPMSPDEWLRKLETNADDDLDTTPKRSGSTRRRQKKVPGDMSDSRNGDVRRQKSTCCCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-05-01" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>P90926</accession>
    <name>P90926_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nematode Specific Peptide family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">nsph-1.1</name>
        <name evidence="1" type="ORF">CELE_K08F8.5</name>
        <name evidence="3" type="ORF">K08F8.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAA91288.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_495864.2">
        <property type="nucleotide sequence ID" value="NM_063463.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P90926"/>
    <dbReference type="SMR" id="P90926"/>
    <dbReference type="PaxDb" id="6239-K08F8.5b"/>
    <dbReference type="GeneID" id="187165"/>
    <dbReference type="UCSC" id="K08F8.5b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010682"/>
    <dbReference type="CTD" id="187165"/>
    <dbReference type="WormBase" id="K08F8.5b">
        <property type="protein sequence ID" value="CE43295"/>
        <property type="gene ID" value="WBGene00010682"/>
        <property type="gene designation" value="nsph-1.1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTBD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068746_0_0_1"/>
    <dbReference type="OMA" id="GFFYEWI"/>
    <dbReference type="OrthoDB" id="5863054at2759"/>
    <dbReference type="PhylomeDB" id="P90926"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010682">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="P90926">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021010">
        <property type="entry name" value="Cytosolic_motility_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578:SF5">
        <property type="entry name" value="NEMATODE SPECIFIC PEPTIDE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578">
        <property type="entry name" value="PROTEIN CBG21223-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12150">
        <property type="entry name" value="MFP2b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141739">
        <property type="entry name" value="MFPT repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA91288.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="K08F8.5b"/>
        </source>
    </evidence>
    <sequence length="363" mass="40660" checksum="92D6362D360FD8C2" modified="2008-12-16" version="2">MDRKGFTMEKGNIDDIWTLQKVGTPFPPNVAKAPGETNKYVALWYKHGKPVMGRAWNDSGVVKCMFVLDDKIYSGADVGGSIQLLILDHIEKSKSFHYDWVNFKKAQSLTIEGKYEMVRCEYSASMYWPEHGLLGCVNTEKLVAHFVDNEMQIKTTKKLEHLLVLCKIAGSRDATEKEKEKGSTGSASKLLTVVNDWEDFNWGSAWPSNKNVMSIPKNIPSAGIDQFVALWYRHGKPIMGRAWQSNGRIEASFVDAKREFTGATVGSLQLLISLPPTTVGYDYVWMTYTQAIDYRDKDYVPVHLSYICPAIVPVDGKFFLGQVNMKTECATVALNGSVTQLDGGPVKSIMVLCRKEMAETMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-05-01" modified="2025-10-08" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>P90952</accession>
    <name>P90952_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lon proteolytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_R13H4.6</name>
        <name evidence="2 4" type="ORF">R13H4.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB04658.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_505987.3">
        <property type="nucleotide sequence ID" value="NM_073586.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P90952"/>
    <dbReference type="SMR" id="P90952"/>
    <dbReference type="MEROPS" id="S16.A08"/>
    <dbReference type="PaxDb" id="6239-R13H4.6"/>
    <dbReference type="GeneID" id="187873"/>
    <dbReference type="UCSC" id="R13H4.6">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011264"/>
    <dbReference type="CTD" id="187873"/>
    <dbReference type="WormBase" id="R13H4.6a">
        <property type="protein sequence ID" value="CE48408"/>
        <property type="gene ID" value="WBGene00011264"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1050661_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="P90952">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="1">
        <location>
            <begin position="100"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB04658.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R13H4.6a"/>
        </source>
    </evidence>
    <sequence length="265" mass="28900" checksum="AB3105FA4D54FBCC" modified="2013-06-26" version="3">MVVSIISKQSTCTNTVIMPARAGGNPSQLNTSIHATRAPADPAIKSISKLEFGKIWVNGLGVIKPNGEQKTSAEKGPIVPIFCTFFKFKTDSFHCYALESIGEDMKEGARLAYDAVTFNLCSMGVSQHPREVRVQYYAESHLDRKSAILTTALGLMAAFTGMIIPDYIAATGKLDLPGNVGDIELKIDAAIQNKKTIVIVPKDNFESISKDMKAQINGVPVSHLLEAFQVVSQQGKKKIIVNCSHSFFAKMSRISLYCAIEIDQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q09279-2</accession>
    <name>YQI6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Uncharacterized protein C45G9.6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">C45G9.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09279-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09279-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_002444 VSP_002443"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741125.1">
        <property type="nucleotide sequence ID" value="NM_171111.8"/>
    </dbReference>
    <dbReference type="WormBase" id="C45G9.6b">
        <property type="protein sequence ID" value="CE30634"/>
        <property type="gene ID" value="WBGene00016677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="155" mass="15384" checksum="A7128528C0BFC603" modified="2002-06-20" version="3">MILALLLLCSTITQFSDGYVIGGGTQPGGNQNNPNSPTYNGGIGGGVYPGGGGNNGGVQRDEGGYCNSNTDCRSGLYCTASVNGVKICLSTSNGGGGNGFPSGNGGCQTSSNCQYGSVCVVTNGQGNCQIQTGGYVSPARQGMVRYPSSNSITVG</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="169" xmlns="https://uniprot.org/uniprot">
    <accession>Q17686</accession>
    <name>Q17686_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acyl-aliphatic-L-amino acid amidohydrolase</fullName>
            <ecNumber evidence="3">3.5.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acyl-L-amino-acid amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="ORF">C06A6.4</name>
        <name evidence="12" type="ORF">CELE_C06A6.4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="3"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD63305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29267">
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        <property type="entry name" value="Zn-dependent exopeptidases"/>
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    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="189"/>
            <end position="294"/>
        </location>
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        </location>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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    <feature type="binding site" evidence="10">
        <location>
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        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <feature type="binding site" evidence="10">
        <location>
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        <ligand>
            <name>Zn(2+)</name>
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        <location>
            <position position="368"/>
        </location>
        <ligand>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00029656"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD63305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="C06A6.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q17686"/>
        </source>
    </evidence>
    <sequence length="397" mass="45465" checksum="A45C53C310FEE1D6" modified="2003-10-01" version="3">MSEDIGVTRFREYLRVNTEQPKPDYEACRDFLFKYADELGIERRSVETAPGTYFVIMTIPGSKPDLPSIMLYSHTDVVPTFREYWTHDPYSAFKDEDGNIFARGAQDMKCVGVQYMEALRNWFAKGVKQWTRTIHIVWGPDEEIGHINGMKGFAVTEEFKKLNIDFALDEGIATEDDVYKIFYAERIPWWVKVTLPGHPGHGSKFIEKTAIEKLHKLIASVDEFRNEQKSLLAEHPEWTVGDVTTSNITIINGGVQVNVVPEKFEAYIDIRVTPLQDLDAVLARVDQWAKEAGEGVTYEFMQFSNFKLISPNTREDPFWAAIDDALQKEGCKYKKEIFIGATDSRFVRAQGIRAIGFSPIINTPSLLHDHNEFLNEKTFLRGVEIYETLINKLANVN</sequence>
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<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="173" xmlns="https://uniprot.org/uniprot">
    <accession>Q19336-2</accession>
    <name>PCGF3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Polycomb group RING finger protein 3 homolog mig-32</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RING-domain-containing protein mig-32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mig-32</name>
        <name evidence="4" type="ORF">F11A10.3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Development" volume="136" first="943" last="953">
            <title>MIG-32 and SPAT-3A are PRC1 homologs that control neuronal migration in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Karakuzu O."/>
                <person name="Wang D.P."/>
                <person name="Cameron S."/>
            </authorList>
            <dbReference type="PubMed" id="19211678"/>
            <dbReference type="DOI" id="10.1242/dev.029363"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19336-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061240"/>
        </isoform>
        <isoform>
            <id>Q19336-1</id>
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            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255621.1">
        <property type="nucleotide sequence ID" value="NM_001268692.3"/>
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    <dbReference type="WormBase" id="F11A10.3b">
        <property type="protein sequence ID" value="CE44701"/>
        <property type="gene ID" value="WBGene00008684"/>
        <property type="gene designation" value="mig-32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="19211678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F11A10.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F11A10.3b"/>
        </source>
    </evidence>
    <sequence length="40" mass="4879" checksum="8F456EB4D5BFE68C" modified="2010-07-13" version="4">MFCDGQLMGKDFSVRFVWMMKRRGQPKSEPLIIRYHMTRT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-08-30" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXS5-2</accession>
    <name>VPS39_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Vacuolar protein sorting-associated protein 39 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">vps-39</name>
        <name evidence="4" type="ORF">T08G5.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="PLoS ONE" volume="4" first="e5117" last="e5117">
            <title>CUTI-1: A novel tetraspan protein involved in C. elegans CUTicle formation and epithelial integrity.</title>
            <authorList>
                <person name="Fritz J.A."/>
                <person name="Behm C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19357781"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0005117"/>
        </citation>
        <scope>INTERACTION WITH CUTI-1</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2014" name="Autophagy" volume="10" first="1868" last="1872">
            <title>Human GABARAP can restore autophagosome biogenesis in a C. elegans lgg-1 mutant.</title>
            <authorList>
                <person name="Jenzer C."/>
                <person name="Manil-Segalen M."/>
                <person name="Lefebvre C."/>
                <person name="Largeau C."/>
                <person name="Glatigny A."/>
                <person name="Legouis R."/>
            </authorList>
            <dbReference type="PubMed" id="25126728"/>
            <dbReference type="DOI" id="10.4161/auto.29745"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2014" name="Dev. Cell" volume="28" first="43" last="55">
            <title>The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39.</title>
            <authorList>
                <person name="Manil-Segalen M."/>
                <person name="Lefebvre C."/>
                <person name="Jenzer C."/>
                <person name="Trichet M."/>
                <person name="Boulogne C."/>
                <person name="Satiat-Jeunemaitre B."/>
                <person name="Legouis R."/>
            </authorList>
            <dbReference type="PubMed" id="24374177"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2013.11.022"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH LGG-2</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2014" name="Mol. Biol. Cell" volume="25" first="1073" last="1096">
            <title>Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1.</title>
            <authorList>
                <person name="Delahaye J.L."/>
                <person name="Foster O.K."/>
                <person name="Vine A."/>
                <person name="Saxton D.S."/>
                <person name="Curtin T.P."/>
                <person name="Somhegyi H."/>
                <person name="Salesky R."/>
                <person name="Hermann G.J."/>
            </authorList>
            <dbReference type="PubMed" id="24501423"/>
            <dbReference type="DOI" id="10.1091/mbc.E13-09-0521"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2014" name="Mol. Biol. Cell" volume="25" first="3909" last="3925">
            <title>Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Solinger J.A."/>
                <person name="Spang A."/>
            </authorList>
            <dbReference type="PubMed" id="25273556"/>
            <dbReference type="DOI" id="10.1091/mbc.E13-12-0710"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q1ZXS5-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_059059"/>
        </isoform>
        <isoform>
            <id>Q1ZXS5-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_059059 VSP_059058"/>
        </isoform>
        <isoform>
            <id>Q1ZXS5-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001041163.1">
        <property type="nucleotide sequence ID" value="NM_001047698.5"/>
    </dbReference>
    <dbReference type="WormBase" id="T08G5.5a">
        <property type="protein sequence ID" value="CE18946"/>
        <property type="gene ID" value="WBGene00011625"/>
        <property type="gene designation" value="vps-39"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T08G5.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T08G5.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T08G5.5c"/>
        </source>
    </evidence>
    <sequence length="923" mass="104950" checksum="34BF7C0AB207F676" modified="2006-04-18" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-08-30" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q1ZXS5-3</accession>
    <name>VPS39_CAEEL</name>
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        <recommendedName>
            <fullName evidence="1">Isoform c of Vacuolar protein sorting-associated protein 39 homolog</fullName>
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    <gene>
        <name evidence="4" type="primary">vps-39</name>
        <name evidence="4" type="ORF">T08G5.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="PLoS ONE" volume="4" first="e5117" last="e5117">
            <title>CUTI-1: A novel tetraspan protein involved in C. elegans CUTicle formation and epithelial integrity.</title>
            <authorList>
                <person name="Fritz J.A."/>
                <person name="Behm C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19357781"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0005117"/>
        </citation>
        <scope>INTERACTION WITH CUTI-1</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2014" name="Autophagy" volume="10" first="1868" last="1872">
            <title>Human GABARAP can restore autophagosome biogenesis in a C. elegans lgg-1 mutant.</title>
            <authorList>
                <person name="Jenzer C."/>
                <person name="Manil-Segalen M."/>
                <person name="Lefebvre C."/>
                <person name="Largeau C."/>
                <person name="Glatigny A."/>
                <person name="Legouis R."/>
            </authorList>
            <dbReference type="PubMed" id="25126728"/>
            <dbReference type="DOI" id="10.4161/auto.29745"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2014" name="Dev. Cell" volume="28" first="43" last="55">
            <title>The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39.</title>
            <authorList>
                <person name="Manil-Segalen M."/>
                <person name="Lefebvre C."/>
                <person name="Jenzer C."/>
                <person name="Trichet M."/>
                <person name="Boulogne C."/>
                <person name="Satiat-Jeunemaitre B."/>
                <person name="Legouis R."/>
            </authorList>
            <dbReference type="PubMed" id="24374177"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2013.11.022"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH LGG-2</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2014" name="Mol. Biol. Cell" volume="25" first="1073" last="1096">
            <title>Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1.</title>
            <authorList>
                <person name="Delahaye J.L."/>
                <person name="Foster O.K."/>
                <person name="Vine A."/>
                <person name="Saxton D.S."/>
                <person name="Curtin T.P."/>
                <person name="Somhegyi H."/>
                <person name="Salesky R."/>
                <person name="Hermann G.J."/>
            </authorList>
            <dbReference type="PubMed" id="24501423"/>
            <dbReference type="DOI" id="10.1091/mbc.E13-09-0521"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2014" name="Mol. Biol. Cell" volume="25" first="3909" last="3925">
            <title>Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Solinger J.A."/>
                <person name="Spang A."/>
            </authorList>
            <dbReference type="PubMed" id="25273556"/>
            <dbReference type="DOI" id="10.1091/mbc.E13-12-0710"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q1ZXS5-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_059059 VSP_059058"/>
        </isoform>
        <isoform>
            <id>Q1ZXS5-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_059059"/>
        </isoform>
        <isoform>
            <id>Q1ZXS5-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001123010.1">
        <property type="nucleotide sequence ID" value="NM_001129538.6"/>
    </dbReference>
    <dbReference type="WormBase" id="T08G5.5c">
        <property type="protein sequence ID" value="CE41694"/>
        <property type="gene ID" value="WBGene00011625"/>
        <property type="gene designation" value="vps-39"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T08G5.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T08G5.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T08G5.5c"/>
        </source>
    </evidence>
    <sequence length="920" mass="104635" checksum="10BB42E711809EC3" modified="2006-04-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q22214</accession>
    <name>Q22214_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T05B9.2</name>
        <name evidence="2 4" type="ORF">T05B9.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAA88961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T24500">
        <property type="entry name" value="T24500"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q22214"/>
    <dbReference type="SMR" id="Q22214"/>
    <dbReference type="PaxDb" id="6239-T05B9.2"/>
    <dbReference type="UCSC" id="T05B9.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011465"/>
    <dbReference type="WormBase" id="T05B9.2a">
        <property type="protein sequence ID" value="CE02311"/>
        <property type="gene ID" value="WBGene00011465"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130584_0_0_1"/>
    <dbReference type="OMA" id="CIEDFSC"/>
    <dbReference type="OrthoDB" id="5782698at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011465">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q22214">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA88961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T05B9.2a"/>
        </source>
    </evidence>
    <sequence length="177" mass="20656" checksum="7399A53A89DF7D19" modified="1996-11-01" version="1">MSIEGGNYRRIRNFVDRECAKECIEDFSCFGYEWNSEEKICYLKSRSTSGKLIAKPNTMVGFCQDDEDEVRYRLQDHVIVGPIVMEADDVPDGEECKENCRKVGALYYSWRPNSDNQRSNVVPVEEEEDDEEQEVLGHCECISTMNELRLEYDAFSGFIPIPKHKHRRSILLRPFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q22218</accession>
    <name>Q22218_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T05C1.2</name>
        <name evidence="2 4" type="ORF">T05C1.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61743.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T16808">
        <property type="entry name" value="T16808"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q22218"/>
    <dbReference type="SMR" id="Q22218"/>
    <dbReference type="UCSC" id="T05C1.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020249"/>
    <dbReference type="WormBase" id="T05C1.2b">
        <property type="protein sequence ID" value="CE52345"/>
        <property type="gene ID" value="WBGene00020249"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TIK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1788569_0_0_1"/>
    <dbReference type="OrthoDB" id="5838463at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020249">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q22218">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD61743.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T05C1.2b"/>
        </source>
    </evidence>
    <sequence length="43" mass="4843" checksum="F298C8F9E8C78ACE" modified="2017-12-20" version="2">MRRFSQADTARHPAAPLLSKLAARQQIPEAVAEKKDDEKPENK</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q23505</accession>
    <accession>Q23506</accession>
    <name>Q23505_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_ZK470.2</name>
        <name evidence="2 4" type="ORF">ZK470.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T27875">
        <property type="entry name" value="T27875"/>
    </dbReference>
    <dbReference type="PIR" id="T27876">
        <property type="entry name" value="T27876"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508704.1">
        <property type="nucleotide sequence ID" value="NM_076303.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q23505"/>
    <dbReference type="PeptideAtlas" id="Q23505"/>
    <dbReference type="GeneID" id="180689"/>
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    <dbReference type="AGR" id="WB:WBGene00022745"/>
    <dbReference type="CTD" id="180689"/>
    <dbReference type="WormBase" id="ZK470.2a">
        <property type="protein sequence ID" value="CE05086"/>
        <property type="gene ID" value="WBGene00022745"/>
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    <dbReference type="HOGENOM" id="CLU_1533957_0_0_1"/>
    <dbReference type="OrthoDB" id="5824236at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022745">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q23505">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD69105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZK470.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q23505"/>
        </source>
    </evidence>
    <sequence length="175" mass="19020" checksum="22E47978F7060ADC" modified="1996-11-01" version="1">MNFVGTNQLETGLHFPCSSAALLSQESLHQPPLRKSSSAIDWNGAVVEATRKTSRQFDWQTALFDNSRKTSFSNLQPFSQAQQGGLVMSNLDNKQQGMSVATATMPQQQNNFAQTLSQSSSTASAPAPTSAPVTTPAPGSRGAALFGGVFHRGFFSKPVERTEEENYRYLMALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q23509</accession>
    <name>Q23509_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MD-2-related lipid-recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_ZK470.6</name>
        <name evidence="3 5" type="ORF">ZK470.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD69111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T27879">
        <property type="entry name" value="T27879"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508709.1">
        <property type="nucleotide sequence ID" value="NM_076308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q23509"/>
    <dbReference type="FunCoup" id="Q23509">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="6239.ZK470.6.1"/>
    <dbReference type="PaxDb" id="6239-ZK470.6"/>
    <dbReference type="GeneID" id="191326"/>
    <dbReference type="UCSC" id="ZK470.6">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022747"/>
    <dbReference type="CTD" id="191326"/>
    <dbReference type="WormBase" id="ZK470.6a">
        <property type="protein sequence ID" value="CE05091"/>
        <property type="gene ID" value="WBGene00022747"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SSFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1112185_0_0_1"/>
    <dbReference type="InParanoid" id="Q23509"/>
    <dbReference type="OMA" id="FRMIHYD"/>
    <dbReference type="OrthoDB" id="5863283at2759"/>
    <dbReference type="PhylomeDB" id="Q23509"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022747">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35573:SF2">
        <property type="entry name" value="MD-2-RELATED LIPID-RECOGNITION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35573">
        <property type="entry name" value="PROTEIN CBG22129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004201462" evidence="2">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD69111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="ZK470.6a"/>
        </source>
    </evidence>
    <sequence length="250" mass="28620" checksum="9C2B1AA7857A14ED" modified="1996-11-01" version="1">MNFRFILLFLIFPFVFASLEEFEQDSAEIKKEVPARFRSFKNFGSHQDASNQAAEVAGSNEDNTDDPEVAPDAPYLMADSSLEQEEECVALPNRTRVRPSFFQCKEDTKFELHGGAITNGNGDDTYPVSFNSPIRIFLDITSNSNKRYDNLGVEVSIFKRSTGWFGCGWMFLPSFGLLSNYDMCDDNPSCPVTPGRQVIEFEIDPTKLFTNLFRMIHYDLSAYQMMVRVRDNRDPYRELLCATIQTRITL</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="170" xmlns="https://uniprot.org/uniprot">
    <accession>Q23542</accession>
    <name>Q23542_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">dnc-1</name>
        <name evidence="12" type="ORF">CELE_ZK593.5</name>
        <name evidence="14" type="ORF">ZK593.5</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA93427.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T27925">
        <property type="entry name" value="T27925"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379109.1">
        <property type="nucleotide sequence ID" value="NM_001392398.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q23542"/>
    <dbReference type="GeneID" id="177987"/>
    <dbReference type="UCSC" id="ZK593.5">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001017"/>
    <dbReference type="CTD" id="177987"/>
    <dbReference type="WormBase" id="ZK593.5a">
        <property type="protein sequence ID" value="CE30718"/>
        <property type="gene ID" value="WBGene00001017"/>
        <property type="gene designation" value="dnc-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="PhylomeDB" id="Q23542"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001017">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q23542">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000235">
        <property type="term" value="C:astral microtubule"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035047">
        <property type="term" value="P:centrosomal and pronuclear rotation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035046">
        <property type="term" value="P:pronuclear migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF93">
        <property type="entry name" value="RESTIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="11">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="978"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1077"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1164"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAA93427.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="ZK593.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q23542"/>
        </source>
    </evidence>
    <sequence length="1326" mass="148430" checksum="CA67A559CF537CEA" modified="2002-10-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-01-24" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q2PJ91</accession>
    <name>Q2PJ91_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sialin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">H(+)/nitrate cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">H(+)/sialic acid cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Vesicular excitatory amino acid transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28 30" type="primary">slc-17.1</name>
        <name evidence="28" type="ORF">CELE_ZK54.1</name>
        <name evidence="30" type="ORF">ZK54.1</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitrate(out) + H(+)(out) = 2 nitrate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71539"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71540"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72591"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:72592"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-aspartate(out) = L-aspartate(in)</text>
            <dbReference type="Rhea" id="RHEA:66332"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66333"/>
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    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-glutamate(out) = L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:66336"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66337"/>
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    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-L-aspartyl-L-glutamate(out) = N-acetyl-L-aspartyl-L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:72599"/>
            <dbReference type="ChEBI" id="CHEBI:76931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:72600"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-acetylneuraminate(in) + H(+)(in) = N-acetylneuraminate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28987"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:28989"/>
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    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD66906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001041301.1">
        <property type="nucleotide sequence ID" value="NM_001047836.7"/>
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    <dbReference type="AlphaFoldDB" id="Q2PJ91"/>
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    <dbReference type="UCSC" id="ZK54.1a">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00022647"/>
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        <property type="protein sequence ID" value="CE39537"/>
        <property type="gene ID" value="WBGene00022647"/>
        <property type="gene designation" value="slc-17.1"/>
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    <dbReference type="HOGENOM" id="CLU_001265_5_0_1"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
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    <dbReference type="Bgee" id="WBGene00022647">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline and differential"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
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        <property type="term" value="F:symporter activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:carboxylic acid transport"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="MFS_SLC17"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
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    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
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    <keyword evidence="9 26" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="35"/>
            <end position="59"/>
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    <feature type="transmembrane region" description="Helical" evidence="26">
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    <feature type="transmembrane region" description="Helical" evidence="26">
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            <begin position="41"/>
            <end position="459"/>
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            <dbReference type="ARBA" id="ARBA00004638"/>
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            <dbReference type="ARBA" id="ARBA00023018"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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            <dbReference type="ARBA" id="ARBA00023228"/>
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            <dbReference type="ARBA" id="ARBA00050101"/>
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            <dbReference type="ARBA" id="ARBA00050554"/>
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            <dbReference type="ARBA" id="ARBA00050625"/>
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    <sequence length="474" mass="52631" checksum="6DFF2403CDECE6FB" modified="2006-01-24" version="1">MEAEPPPSRTLPYGTSETIDDDEALESKRWKRRHVVAILALLGFANIYAMRANLSIAIVEMTSGTERKVNGTTLHVLGDFENWTPMTQGVVLSSFFYGYIVSQLPGGYLAYTHGAKTIFFAGTFGTAVFTLLTPPFARMGYGMLVFARFMEGLLEGVTYPAMHVIWSRWAPPMEQTKLATFAFSGSYFGTVVAMPLSAYLGEHFGWPMIFWFFGALGVIWCMVWYKTVHDRPEDDPKISTSELALLQRDAVSQNHYIVPWAQILRSKPVWAVIVAHSAQNLGFYIMLTNLPKMLKDIAGYNVEKAGIASSLPYFLMGFQIITGGQLCDYLRRDKHYDTLFVRKMACALGFIGQSVFLFLVMTTSNSLLLVLFFSISIGLGGICWCGFSVNHLDLAPQYAGHLMATSNTFATIPGIFGPLLVGAIVQNGTIGEWNVIMYIIISAYLLGAAIFWKFADATLQPWAAEHTSFVGQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-01-24" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q2PJ95</accession>
    <name>Q2PJ95_CAEEL</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="16" type="ORF">T21F2.1</name>
    </gene>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
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        <property type="nucleotide sequence ID" value="NM_001392910.1"/>
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    <dbReference type="UCSC" id="T21F2.1a">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="WormBase" id="T21F2.1b">
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        <property type="gene ID" value="WBGene00020657"/>
        <property type="gene designation" value="lgc-53"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005230">
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        <property type="entry name" value="LGIC_TM_anion"/>
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    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
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        <property type="entry name" value="Neur_channel"/>
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        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
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        <property type="entry name" value="Neuro_actylchol_rec"/>
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    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
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        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="83"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD64118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="T21F2.1b"/>
        </source>
    </evidence>
    <sequence length="278" mass="32430" checksum="4418C79E8FDFE4B9" modified="2006-01-24" version="1">MDRQSCNLVFESYSYNTAEVRIVWRDWDAVTIPDPDSKNLPDFELVNIEHMNATLVYTAGLWDQLEVKFTFRRLYGYYVLQAYMPTYLSVFISWIAFWIDTKALPARITLGVSSLMALTFQFGNIVKNLPRVSYVKALDIWMFGCVGFIFLSLVELAVVGFADKLEAKRRRHNRCKEQLMMRSDSEQQWLSRLSGQRPQVSETNSDATHTIQINDGNGNVRRRKSEEKRQKLLLQMESPMFVNGEKIDEISAKLFPLLFTAFNIFYWFYYIGMSGGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JKI1</accession>
    <name>Q7JKI1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <ecNumber evidence="4">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">pck-2</name>
        <name evidence="17" type="ORF">CELE_R11A5.4</name>
        <name evidence="19" type="ORF">R11A5.4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="function">
        <text evidence="13">In parasitic nematodes PEPCK carboxylates phosphoenolpyruvate to oxaloacetate thus introducing the products of glycolysis to mitochondrial metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAF31484.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379420.1">
        <property type="nucleotide sequence ID" value="NM_001392619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JKI1"/>
    <dbReference type="SMR" id="Q7JKI1"/>
    <dbReference type="PeptideAtlas" id="Q7JKI1"/>
    <dbReference type="GeneID" id="172556"/>
    <dbReference type="UCSC" id="R11A5.4b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011232"/>
    <dbReference type="CTD" id="172556"/>
    <dbReference type="WormBase" id="R11A5.4b">
        <property type="protein sequence ID" value="CE53966"/>
        <property type="gene ID" value="WBGene00011232"/>
        <property type="gene designation" value="pck-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841594at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011232">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JKI1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF16">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="16">
        <location>
            <begin position="35"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="15">
        <location>
            <begin position="266"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAF31484.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="R11A5.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="Q7JKI1"/>
        </source>
    </evidence>
    <sequence length="629" mass="70706" checksum="0384BAB10C58D52A" modified="2020-04-22" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JKI2</accession>
    <name>Q7JKI2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <ecNumber evidence="4">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">pck-2</name>
        <name evidence="17" type="ORF">CELE_R11A5.4</name>
        <name evidence="19" type="ORF">R11A5.4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="function">
        <text evidence="13">In parasitic nematodes PEPCK carboxylates phosphoenolpyruvate to oxaloacetate thus introducing the products of glycolysis to mitochondrial metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAF31483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367091.1">
        <property type="nucleotide sequence ID" value="NM_001380768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JKI2"/>
    <dbReference type="SMR" id="Q7JKI2"/>
    <dbReference type="PeptideAtlas" id="Q7JKI2"/>
    <dbReference type="GeneID" id="172556"/>
    <dbReference type="UCSC" id="R11A5.4b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011232"/>
    <dbReference type="CTD" id="172556"/>
    <dbReference type="WormBase" id="R11A5.4d">
        <property type="protein sequence ID" value="CE36360"/>
        <property type="gene ID" value="WBGene00011232"/>
        <property type="gene designation" value="pck-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841594at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011232">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JKI2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF16">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="16">
        <location>
            <begin position="24"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="15">
        <location>
            <begin position="255"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAF31483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="R11A5.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="Q7JKI2"/>
        </source>
    </evidence>
    <sequence length="618" mass="69523" checksum="686201679AF26153" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JKI3</accession>
    <name>Q7JKI3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <ecNumber evidence="4">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">pck-2</name>
        <name evidence="17" type="ORF">CELE_R11A5.4</name>
        <name evidence="19" type="ORF">R11A5.4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="function">
        <text evidence="13">In parasitic nematodes PEPCK carboxylates phosphoenolpyruvate to oxaloacetate thus introducing the products of glycolysis to mitochondrial metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAF31482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367090.1">
        <property type="nucleotide sequence ID" value="NM_001380772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JKI3"/>
    <dbReference type="SMR" id="Q7JKI3"/>
    <dbReference type="PeptideAtlas" id="Q7JKI3"/>
    <dbReference type="GeneID" id="172556"/>
    <dbReference type="UCSC" id="R11A5.4b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011232"/>
    <dbReference type="CTD" id="172556"/>
    <dbReference type="WormBase" id="R11A5.4c">
        <property type="protein sequence ID" value="CE36359"/>
        <property type="gene ID" value="WBGene00011232"/>
        <property type="gene designation" value="pck-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028872_1_1_1"/>
    <dbReference type="OrthoDB" id="5841594at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011232">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JKI3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
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    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF16">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="15">
        <location>
            <begin position="224"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAF31482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="R11A5.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="Q7JKI3"/>
        </source>
    </evidence>
    <sequence length="587" mass="65984" checksum="5F231AF9D07F3776" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="160" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JKI4</accession>
    <name>Q7JKI4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">AcetylCholine Receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">acr-20</name>
        <name evidence="17" type="ORF">CELE_R06A4.10</name>
        <name evidence="19" type="ORF">R06A4.10</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAE46678.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022273.1">
        <property type="nucleotide sequence ID" value="NM_001027102.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JKI4"/>
    <dbReference type="SMR" id="Q7JKI4"/>
    <dbReference type="GeneID" id="187632"/>
    <dbReference type="KEGG" id="cel:CELE_R06A4.10"/>
    <dbReference type="UCSC" id="R06A4.10a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000059"/>
    <dbReference type="CTD" id="187632"/>
    <dbReference type="WormBase" id="R06A4.10b">
        <property type="protein sequence ID" value="CE36709"/>
        <property type="gene ID" value="WBGene00000059"/>
        <property type="gene designation" value="acr-20"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018074_2_5_1"/>
    <dbReference type="OrthoDB" id="5802429at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000059">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JKI4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000049">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000031">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="3"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="203"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAE46678.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="R06A4.10b"/>
        </source>
    </evidence>
    <sequence length="511" mass="58783" checksum="5DB6E84EC0C8B533" modified="2004-09-13" version="2">MGKKSPIEVHFSMELYQIISVNEPQQFLMLNAWVVERWTDRLLGWDPEKFGNVTEIMLPHHFIWLPDTTLYNSLVMKDDENRRLLHAKVTTLGEGNGAFIELLYPTIYKLSCLLNLRFFPFDVQSCRLLFGSWTFDNTKIDYFAFNESQAIGTTNCIENEGWNVLSTSVIRHENKYDCCPNNYTLLEFRLTIQRKPLYYIINLIIPTSIITFISIIGFFSTSSINEPREEKITLGITTLLSMSILIFMVSDKMPSTSSFIPLIGLFYTSMILLISFSTICSSVVIYVQKQGNLGNPPSKNFMNIARAVNRFIRMEMPLIMKQAYAQKAREEKLRRQQMGRKQSLWTRVYKLAREQALRKTSQNSSKFNEVLTPEKLIDNGGKRCTINKDVTCISDSGIVAMGVPTLASEDDDQDVSLLELETTPTPAMQRPTRLHKASTCGSFDSMMFRQIEVPVSPRTARNLAEIEYDWLAALLERIFLITFLFIFVLTSIGINLIGFFYWWMAPDTVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JKM0</accession>
    <name>Q7JKM0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TEP1-F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">tep-1</name>
        <name evidence="11" type="ORF">CELE_ZK337.1</name>
        <name evidence="13" type="ORF">ZK337.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a TEP1-N chain and an TEP1-C chain non-covalently linked. Forms a complex composed of TEP1-N and TEP1-C heterodimer, LRIM1 and APL1C; the interaction stabilizes TEP1-N and TEP1-C heterodimer, prevents its binding to tissues while circulating in the hemolymph and protects the thioester bond from hydrolysis. Mature TEP1 and to a lesser extent full-length TEP1 interact with SPCLIP1; the interaction is induced by microbial infection.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB05006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379225.1">
        <property type="nucleotide sequence ID" value="NM_001392981.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q7JKM0"/>
    <dbReference type="GeneID" id="173367"/>
    <dbReference type="UCSC" id="ZK337.1c.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013969"/>
    <dbReference type="CTD" id="173367"/>
    <dbReference type="WormBase" id="ZK337.1a">
        <property type="protein sequence ID" value="CE16718"/>
        <property type="gene ID" value="WBGene00013969"/>
        <property type="gene designation" value="tep-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013969">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JKM0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF175">
        <property type="entry name" value="TEP (THIOLESTER CONTAINING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004287645" description="TEP1-F" evidence="7">
        <location>
            <begin position="21"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="8">
        <location>
            <begin position="495"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="9">
        <location>
            <begin position="750"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="10">
        <location>
            <begin position="1365"/>
            <end position="1454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB05006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="ZK337.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q7JKM0"/>
        </source>
    </evidence>
    <sequence length="1508" mass="167191" checksum="A49CFF65FA067FAE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JKN1</accession>
    <name>Q7JKN1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_W09H1.1</name>
        <name evidence="3 5" type="ORF">W09H1.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAE46685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022403.1">
        <property type="nucleotide sequence ID" value="NM_001027232.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JKN1"/>
    <dbReference type="SMR" id="Q7JKN1"/>
    <dbReference type="GeneID" id="174961"/>
    <dbReference type="UCSC" id="W09H1.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012372"/>
    <dbReference type="CTD" id="174961"/>
    <dbReference type="WormBase" id="W09H1.1b">
        <property type="protein sequence ID" value="CE35639"/>
        <property type="gene ID" value="WBGene00012372"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696822_0_0_1"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012372">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JKN1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF529">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE46685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W09H1.1b"/>
        </source>
    </evidence>
    <sequence length="395" mass="43957" checksum="D5F559304797B8CD" modified="2004-07-05" version="1">MKGSSKSATYQSPNAKPLTVRARAGSTPGLDSKQIHSLINKNNTFNRILCKNADTVDSPTPTPSLTASRSSSVISIASTVSTETVVSSGRLIKVAPAKVRQSKSASRWPGFCHSVQDTFSILSDECDVTETPRTPVSLSNVEIFDSDNDYPGTGLSPKSPPFSEGSEDVFERVKTAKVPTTPVKASVTNPFRSLYIDEVVWQIDDVVFASAIDAVNNNSLMCRLNIEFICEIADETADHVQEARRQNRGFECPCFCNRSSSHFRYYLSYSLPETEQRCMMLTEDTKLNDMFDGFLDLVQRARRAKRNVLVCSTRGRNRAPAFASAYLMSKEQIPRQAAVAKVRTAMGTMRPPVNISDFMQRKLMRYQQHLGIDLSNAYDPTHTLPLFHVKRSAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JKP1</accession>
    <name>Q7JKP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">scrm-1</name>
        <name evidence="3" type="ORF">CELE_T22H2.5</name>
        <name evidence="5" type="ORF">T22H2.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB04755.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379216.1">
        <property type="nucleotide sequence ID" value="NM_001392951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JKP1"/>
    <dbReference type="GeneID" id="173053"/>
    <dbReference type="UCSC" id="T22H2.5a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011935"/>
    <dbReference type="CTD" id="173053"/>
    <dbReference type="WormBase" id="T22H2.5a">
        <property type="protein sequence ID" value="CE36204"/>
        <property type="gene ID" value="WBGene00011935"/>
        <property type="gene designation" value="scrm-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10041953at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011935">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JKP1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF63">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB04755.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T22H2.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q7JKP1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32084" checksum="8CC553ABF1723FDE" modified="2004-07-05" version="1">MQQPVINQQPGYNPQGMNPVQQFEMHQQQHQQAITTQPGVFVQPAPGSVWMPMPPAIQGVPTGLEYLTYLDTIMVHQIKELIEIVTDWETKNKYVLKNANGEQCYYAFEESGCCERQCCGPQRGFVMHIVDNFKREVLTIKREFKCCGGGCCGCLACIGCCQQECIIETPSMGVLGIIRQRCGCMSSNYDIMDGDGNVIFQIDGPCCCMLCGCQDKEFPIKTANNGTVVGAITKKWGGCFREAFTDADTFAVNFPGDLDVKLKGVLIGATFLIDFMEFEQQSQNRNNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JKP7</accession>
    <name>Q7JKP7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srh-75</name>
        <name evidence="2" type="ORF">CELE_T04C12.2</name>
        <name evidence="4" type="ORF">T04C12.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAE53738.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024100.2">
        <property type="nucleotide sequence ID" value="NM_001028929.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JKP7"/>
    <dbReference type="SMR" id="Q7JKP7"/>
    <dbReference type="GeneID" id="188057"/>
    <dbReference type="UCSC" id="T04C12.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00005296"/>
    <dbReference type="CTD" id="188057"/>
    <dbReference type="WormBase" id="T04C12.2b">
        <property type="protein sequence ID" value="CE48106"/>
        <property type="gene ID" value="WBGene00005296"/>
        <property type="gene designation" value="srh-75"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042960_2_2_1"/>
    <dbReference type="OrthoDB" id="5838269at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019422">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053220">
        <property type="entry name" value="Nematode_rcpt-like_serp_H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22941">
        <property type="entry name" value="SERPENTINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22941:SF302">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10318">
        <property type="entry name" value="7TM_GPCR_Srh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE53738.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T04C12.2b"/>
        </source>
    </evidence>
    <sequence length="330" mass="38149" checksum="6C9C68E6B36D60EB" modified="2013-04-03" version="2">MTTSTNLYYSNEWKKKCSNDSSFLASWQGLSVFSHSMCCYVDILICSLITPYFFFPTISGFPVGLLRVLKVPTSVQVLIGFISALFMAISLVALFENRSSAIQNNKFRITKKRWKLLYYSVNCFIVLVYLIPPYCNVPEQESAKLHLLQAIPCPTEEFFYSDVFVWTIDKFWINYLWMSTGVIVLMLFSQLGFFTICCIYYLYISTAIMISSNTRKFQRSFFLGTITQAVVPLIFLLLPVIIGIVVIYCEYYNQELNNSLVLFLSLHGFTSTFVIILVHHPYRRFLIKVVTFDRSAEVTGISYITKGARVDNNVLRRLPNRTSPYIRTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2025-10-08" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JL02</accession>
    <name>Q7JL02_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_T01D3.3</name>
        <name evidence="5 7" type="ORF">T01D3.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB03259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_506390.1">
        <property type="nucleotide sequence ID" value="NM_073989.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JL02"/>
    <dbReference type="SMR" id="Q7JL02"/>
    <dbReference type="GeneID" id="179861"/>
    <dbReference type="UCSC" id="T01D3.3b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011328"/>
    <dbReference type="CTD" id="179861"/>
    <dbReference type="WormBase" id="T01D3.3a">
        <property type="protein sequence ID" value="CE18162"/>
        <property type="gene ID" value="WBGene00011328"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011328">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JL02">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="82"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="150"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="279"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="420"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="576"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB03259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="T01D3.3a"/>
        </source>
    </evidence>
    <sequence length="802" mass="86644" checksum="DA102AF631A26813" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q7YWZ3</accession>
    <name>Q7YWZ3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_M05D6.9</name>
        <name evidence="3 5" type="ORF">M05D6.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAE17856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022254.1">
        <property type="nucleotide sequence ID" value="NM_001027083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7YWZ3"/>
    <dbReference type="PaxDb" id="6239-M05D6.9"/>
    <dbReference type="GeneID" id="3564998"/>
    <dbReference type="KEGG" id="cel:CELE_M05D6.9"/>
    <dbReference type="UCSC" id="M05D6.9">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010881"/>
    <dbReference type="CTD" id="3564998"/>
    <dbReference type="WormBase" id="M05D6.9a">
        <property type="protein sequence ID" value="CE34947"/>
        <property type="gene ID" value="WBGene00010881"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SNXS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1027552_0_0_1"/>
    <dbReference type="OMA" id="FIMNYTS"/>
    <dbReference type="OrthoDB" id="5868576at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010881">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7YWZ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004298349" evidence="2">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE17856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="M05D6.9a"/>
        </source>
    </evidence>
    <sequence length="271" mass="31692" checksum="0324DF24BB3B3B18" modified="2003-10-01" version="1">MQLCLLTFFILILFSFLVESRIPRARYRKRGPTGFSLARIQKEYDEDYDSTDDSSTSRKSSVDGSRRRDEVVNDAKCLQKCNNQLNIGMDMVNAHMAFGSIDVPSVVEKRDLEMFCMLDYQHSQCIDECGYSVQFNLREYVCRNRFPEMLQHLPCYARAAPALIRHCRPRCGGYKALVHTQDGYSQRCRQLLCDHTCSTYILKRLCPEETGIAAANYLLEFTRLQVDYWMKDFTKQAKSRVPLTCRKVQCKDFKLANCRTQKRYRKRVVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q7YWZ4</accession>
    <name>Q7YWZ4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_M05D6.8</name>
        <name evidence="4 6" type="ORF">M05D6.8</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAE17855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254150.1">
        <property type="nucleotide sequence ID" value="NM_001267221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7YWZ4"/>
    <dbReference type="SMR" id="Q7YWZ4"/>
    <dbReference type="GeneID" id="3565415"/>
    <dbReference type="UCSC" id="M05D6.8">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010880"/>
    <dbReference type="CTD" id="3565415"/>
    <dbReference type="WormBase" id="M05D6.8a">
        <property type="protein sequence ID" value="CE34946"/>
        <property type="gene ID" value="WBGene00010880"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872986at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010880">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7YWZ4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219">
        <property type="entry name" value="PROTEIN CBG11138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219:SF5">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004295070" evidence="2">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAE17855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="M05D6.8a"/>
        </source>
    </evidence>
    <sequence length="155" mass="17894" checksum="6EB1D61A35D38E69" modified="2003-10-01" version="1">MFSIRLVFFVFFLVISVKSFINHLNPESTFNEEQFLMRDVKSDQHIDQEGSGEDNEDVLINENSTTTSISESTTTTTVTKITTAAPKPINCYDISKRCSKVKPLCTRNEYKTIMMRQCAKTCGFCPQFVRLPQTSRCRDSFQRYKSKNIAIRKCF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-04-30" modified="2026-01-28" version="172" xmlns="https://uniprot.org/uniprot">
    <accession>Q8WQG9-2</accession>
    <name>JNK1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Stress-activated protein kinase jnk-1</fullName>
            <ecNumber evidence="1 2 3">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">jnk-1</name>
        <name type="ORF">B0478.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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    <reference key="2">
        <citation type="journal article" date="1999" name="EMBO J." volume="18" first="3604" last="3615">
            <title>A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons.</title>
            <authorList>
                <person name="Kawasaki M."/>
                <person name="Hisamoto N."/>
                <person name="Iino Y."/>
                <person name="Yamamoto M."/>
                <person name="Ninomiya-Tsuji J."/>
                <person name="Matsumoto K."/>
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        <scope>ACTIVITY REGULATION</scope>
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        <scope>TISSUE SPECIFICITY</scope>
    </reference>
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            <title>jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Villanueva A."/>
                <person name="Lozano J."/>
                <person name="Morales A."/>
                <person name="Lin X."/>
                <person name="Deng X."/>
                <person name="Hengartner M.O."/>
                <person name="Kolesnick R.N."/>
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        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
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    <reference key="4">
        <citation type="journal article" date="2001" name="Neuron" volume="32" first="787" last="800">
            <title>UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans.</title>
            <authorList>
                <person name="Byrd D.T."/>
                <person name="Kawasaki M."/>
                <person name="Walcoff M."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
                <person name="Jin Y."/>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
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    <reference key="5">
        <citation type="journal article" date="2005" name="Proc. Natl. Acad. Sci. U.S.A." volume="102" first="4494" last="4499">
            <title>JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.</title>
            <authorList>
                <person name="Oh S.W."/>
                <person name="Mukhopadhyay A."/>
                <person name="Svrzikapa N."/>
                <person name="Jiang F."/>
                <person name="Davis R.J."/>
                <person name="Tissenbaum H.A."/>
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            <dbReference type="DOI" id="10.1073/pnas.0500749102"/>
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        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
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        <scope>PHOSPHORYLATION AT THR-276 AND TYR-278</scope>
        <scope>MUTAGENESIS OF THR-276 AND TYR-278</scope>
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    <reference key="6">
        <citation type="journal article" date="2008" name="Chem. Res. Toxicol." volume="21" first="1530" last="1535">
            <title>Arsenite-induced germline apoptosis through a MAPK-dependent, p53-independent pathway in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Pei B."/>
                <person name="Wang S."/>
                <person name="Guo X."/>
                <person name="Wang J."/>
                <person name="Yang G."/>
                <person name="Hang H."/>
                <person name="Wu L."/>
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            <dbReference type="DOI" id="10.1021/tx800074e"/>
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        <scope>FUNCTION</scope>
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    <reference key="7">
        <citation type="journal article" date="2008" name="J. Cell. Physiol." volume="214" first="721" last="729">
            <title>The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness.</title>
            <authorList>
                <person name="Wolf M."/>
                <person name="Nunes F."/>
                <person name="Henkel A."/>
                <person name="Heinick A."/>
                <person name="Paul R.J."/>
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            <dbReference type="DOI" id="10.1002/jcp.21269"/>
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        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>PHOSPHORYLATION AT THR-276 AND TYR-278</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2009" name="Chem. Biol. Interact." volume="180" first="151" last="157">
            <title>Copper-induced germline apoptosis in Caenorhabditis elegans: the independent roles of DNA damage response signaling and the dependent roles of MAPK cascades.</title>
            <authorList>
                <person name="Wang S."/>
                <person name="Wu L."/>
                <person name="Wang Y."/>
                <person name="Luo X."/>
                <person name="Lu Y."/>
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            <dbReference type="DOI" id="10.1016/j.cbi.2009.03.012"/>
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        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="NeuroToxicology" volume="38" first="51" last="60">
            <title>The Nrf2/SKN-1-dependent glutathione S-transferase pi homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism.</title>
            <authorList>
                <person name="Settivari R."/>
                <person name="VanDuyn N."/>
                <person name="LeVora J."/>
                <person name="Nass R."/>
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        <scope>FUNCTION</scope>
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    <reference key="10">
        <citation type="journal article" date="2018" name="BMC Neurosci." volume="19" first="10" last="10">
            <title>Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep.</title>
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                <person name="Khoruzhik Y."/>
                <person name="Hayden D."/>
                <person name="Huang H."/>
                <person name="Sanders J."/>
                <person name="Walsh M.B."/>
                <person name="Biron D."/>
                <person name="Hart A.C."/>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002010" last="E1002010">
            <title>A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Nelson M.D."/>
                <person name="Zhou E."/>
                <person name="Kiontke K."/>
                <person name="Fradin H."/>
                <person name="Maldonado G."/>
                <person name="Martin D."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1002010"/>
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        <citation type="journal article" date="2014" name="Dev. Cell" volume="28" first="697" last="710">
            <title>DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation.</title>
            <authorList>
                <person name="Horn M."/>
                <person name="Geisen C."/>
                <person name="Cermak L."/>
                <person name="Becker B."/>
                <person name="Nakamura S."/>
                <person name="Klein C."/>
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        <citation type="journal article" date="2014" name="PLoS Genet." volume="10" first="E1004428" last="E1004428">
            <title>BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans.</title>
            <authorList>
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                <person name="Cho C.Y."/>
                <person name="Cheng Y.T."/>
                <person name="Huang J.W."/>
                <person name="Wu Y.Z."/>
                <person name="Yeh A.Y."/>
                <person name="Nishiwaki K."/>
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        <citation type="journal article" date="2015" name="Biochim. Biophys. Acta" volume="1849" first="1229" last="1236">
            <title>Direct and positive regulation of Caenorhabditis elegans bed-3 by PRDM1/BLIMP1 ortholog BLMP-1.</title>
            <authorList>
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            <title>LDB1 and the SWI/SNF complex participate in both transcriptional activation and repression by Caenorhabditis elegans BLIMP1/PRDM1.</title>
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        <citation type="journal article" date="2005" name="J. Mol. Evol." volume="60" first="577" last="586">
            <title>Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes.</title>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2000" name="Nature" volume="408" first="470" last="475">
            <title>MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans.</title>
            <authorList>
                <person name="Ranganathan R."/>
                <person name="Cannon S.C."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="11100728"/>
            <dbReference type="DOI" id="10.1038/35044083"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ALA-281</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2003" name="J. Am. Chem. Soc." volume="125" first="6850" last="6851">
            <title>Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge?</title>
            <authorList>
                <person name="Mu T.W."/>
                <person name="Lester H.A."/>
                <person name="Dougherty D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12783521"/>
            <dbReference type="DOI" id="10.1021/ja0348086"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2005" name="J. Biol. Chem." volume="280" first="27502" last="27507">
            <title>Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability.</title>
            <authorList>
                <person name="Menard C."/>
                <person name="Horvitz H.R."/>
                <person name="Cannon S."/>
            </authorList>
            <dbReference type="PubMed" id="15878844"/>
            <dbReference type="DOI" id="10.1074/jbc.m501624200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 266-LYS--ALA-267; 266-LYS--THR-272 AND ALA-270</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2005" name="J. Neurosci." volume="25" first="10671" last="10681">
            <title>The G-protein-coupled serotonin receptor SER-1 regulates egg laying and male mating behaviors in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Carnell L."/>
                <person name="Illi J."/>
                <person name="Hong S.W."/>
                <person name="McIntire S.L."/>
            </authorList>
            <dbReference type="PubMed" id="16291940"/>
            <dbReference type="DOI" id="10.1523/jneurosci.3399-05.2005"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="179" last="184">
            <title>Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Lu H."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="16281027"/>
            <dbReference type="DOI" id="10.1038/nature04216"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="7">
        <citation type="journal article" date="2009" name="J. Neurosci." volume="29" first="1446" last="1456">
            <title>Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Harris G.P."/>
                <person name="Hapiak V.M."/>
                <person name="Wragg R.T."/>
                <person name="Miller S.B."/>
                <person name="Hughes L.J."/>
                <person name="Hobson R.J."/>
                <person name="Steven R."/>
                <person name="Bamber B."/>
                <person name="Komuniecki R.W."/>
            </authorList>
            <dbReference type="PubMed" id="19193891"/>
            <dbReference type="DOI" id="10.1523/jneurosci.4585-08.2009"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="8">
        <citation type="journal article" date="2012" name="Genetics" volume="192" first="1359" last="1371">
            <title>Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Guerel G."/>
                <person name="Gustafson M.A."/>
                <person name="Pepper J.S."/>
                <person name="Horvitz H.R."/>
                <person name="Koelle M.R."/>
            </authorList>
            <dbReference type="PubMed" id="23023001"/>
            <dbReference type="DOI" id="10.1534/genetics.112.142125"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="2" key="9">
        <citation type="journal article" date="2013" name="Cell" volume="154" first="1023" last="1035">
            <title>Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans.</title>
            <authorList>
                <person name="Flavell S.W."/>
                <person name="Pokala N."/>
                <person name="Macosko E.Z."/>
                <person name="Albrecht D.R."/>
                <person name="Larsch J."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="23972393"/>
            <dbReference type="DOI" id="10.1016/j.cell.2013.08.001"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="2" key="10">
        <citation type="journal article" date="2013" name="Cell Metab." volume="18" first="672" last="684">
            <title>An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat.</title>
            <authorList>
                <person name="Noble T."/>
                <person name="Stieglitz J."/>
                <person name="Srinivasan S."/>
            </authorList>
            <dbReference type="PubMed" id="24120942"/>
            <dbReference type="DOI" id="10.1016/j.cmet.2013.09.007"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9GQ00-2</id>
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        <isoform>
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    </dbReference>
    <dbReference type="WormBase" id="K06C4.6b">
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    <proteinExistence type="evidence at transcript level"/>
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        <source>
            <dbReference type="PubMed" id="11100728"/>
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    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAG36975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="K06C4.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="K06C4.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K06C4.6c"/>
        </source>
    </evidence>
    <sequence length="475" mass="54547" checksum="984B0C10A8D055DC" modified="2001-03-01" version="1" precursor="true">MKFIPEITLLLLLFVHSTQAKGKRRKCPEGAWSEGKIMNTIMSNYTKMLPDAEDSVQVNIEIHVQDMGSLNEISSDFEIDILFTQLWHDSALSFAHLPACKRNITMETRLLPKIWSPNTCMINSKRTTVHASPSENVMVILYENGTVWINHRLSVKSPCNLDLRQFPFDTQTCILIFESYSHNSEEVELHWMEEAVTLMKPIQLPDFDMVHYSTKKETLLYPNGYWDQLQVTFTFKRRYGFYIIQAYVPTYLTIIVSWVSFCMEPKALPARTTVGISSLLALTFQFGNILKNLPRVSYVKAMDVWMLGCISFVFGTMVELAFVCYISRCQNSVRNAERRRERMRNSQVWANGSCRTRSNGYANGGSVISHYHPTSNGNGNNNRHDTPQVTGRGSLHRNGPPSPLNLQMTTFDSEIPLTFDQMRSTSPPPPSGCLARFHPEAVDKFSIVAFPLAFTMFNLVYWWHYLSQTFDQNYQ</sequence>
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    <accession>Q9GQ00-3</accession>
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        <recommendedName>
            <fullName evidence="1">Isoform c of Serotonin-gated chloride channel mod-1</fullName>
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        <alternativeName>
            <fullName evidence="5">Modulation Of locomotion defective protein 1</fullName>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2000" name="Nature" volume="408" first="470" last="475">
            <title>MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans.</title>
            <authorList>
                <person name="Ranganathan R."/>
                <person name="Cannon S.C."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="11100728"/>
            <dbReference type="DOI" id="10.1038/35044083"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ALA-281</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2003" name="J. Am. Chem. Soc." volume="125" first="6850" last="6851">
            <title>Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge?</title>
            <authorList>
                <person name="Mu T.W."/>
                <person name="Lester H.A."/>
                <person name="Dougherty D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12783521"/>
            <dbReference type="DOI" id="10.1021/ja0348086"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2005" name="J. Biol. Chem." volume="280" first="27502" last="27507">
            <title>Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability.</title>
            <authorList>
                <person name="Menard C."/>
                <person name="Horvitz H.R."/>
                <person name="Cannon S."/>
            </authorList>
            <dbReference type="PubMed" id="15878844"/>
            <dbReference type="DOI" id="10.1074/jbc.m501624200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 266-LYS--ALA-267; 266-LYS--THR-272 AND ALA-270</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2005" name="J. Neurosci." volume="25" first="10671" last="10681">
            <title>The G-protein-coupled serotonin receptor SER-1 regulates egg laying and male mating behaviors in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Carnell L."/>
                <person name="Illi J."/>
                <person name="Hong S.W."/>
                <person name="McIntire S.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1523/jneurosci.3399-05.2005"/>
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        <scope>FUNCTION</scope>
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    <reference evidence="2" key="6">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="179" last="184">
            <title>Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Lu H."/>
                <person name="Bargmann C.I."/>
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            <dbReference type="PubMed" id="16281027"/>
            <dbReference type="DOI" id="10.1038/nature04216"/>
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        <scope>FUNCTION</scope>
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    <reference evidence="2" key="7">
        <citation type="journal article" date="2009" name="J. Neurosci." volume="29" first="1446" last="1456">
            <title>Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Harris G.P."/>
                <person name="Hapiak V.M."/>
                <person name="Wragg R.T."/>
                <person name="Miller S.B."/>
                <person name="Hughes L.J."/>
                <person name="Hobson R.J."/>
                <person name="Steven R."/>
                <person name="Bamber B."/>
                <person name="Komuniecki R.W."/>
            </authorList>
            <dbReference type="PubMed" id="19193891"/>
            <dbReference type="DOI" id="10.1523/jneurosci.4585-08.2009"/>
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        <scope>FUNCTION</scope>
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    <reference evidence="2" key="8">
        <citation type="journal article" date="2012" name="Genetics" volume="192" first="1359" last="1371">
            <title>Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Guerel G."/>
                <person name="Gustafson M.A."/>
                <person name="Pepper J.S."/>
                <person name="Horvitz H.R."/>
                <person name="Koelle M.R."/>
            </authorList>
            <dbReference type="PubMed" id="23023001"/>
            <dbReference type="DOI" id="10.1534/genetics.112.142125"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="2" key="9">
        <citation type="journal article" date="2013" name="Cell" volume="154" first="1023" last="1035">
            <title>Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans.</title>
            <authorList>
                <person name="Flavell S.W."/>
                <person name="Pokala N."/>
                <person name="Macosko E.Z."/>
                <person name="Albrecht D.R."/>
                <person name="Larsch J."/>
                <person name="Bargmann C.I."/>
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            <dbReference type="PubMed" id="23972393"/>
            <dbReference type="DOI" id="10.1016/j.cell.2013.08.001"/>
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        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="2" key="10">
        <citation type="journal article" date="2013" name="Cell Metab." volume="18" first="672" last="684">
            <title>An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat.</title>
            <authorList>
                <person name="Noble T."/>
                <person name="Stieglitz J."/>
                <person name="Srinivasan S."/>
            </authorList>
            <dbReference type="PubMed" id="24120942"/>
            <dbReference type="DOI" id="10.1016/j.cmet.2013.09.007"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
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            <sequence type="described" ref="VSP_061452 VSP_061453"/>
        </isoform>
        <isoform>
            <id>Q9GQ00-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_061451"/>
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    <dbReference type="RefSeq" id="NP_001024035.1">
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    <proteinExistence type="evidence at transcript level"/>
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        <source>
            <dbReference type="PubMed" id="11100728"/>
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    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAG36975.1"/>
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    <evidence type="ECO:0000312" key="4">
        <source>
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    <evidence type="ECO:0000312" key="5">
        <source>
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    <evidence type="ECO:0000312" key="6">
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    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K06C4.6c"/>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
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            <sequence type="described" ref="VSP_025998"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="381" mass="44483" checksum="B224ED9936924F15" modified="2000-05-01" version="1">MSSHRRGSFRGRKRFYRDTFAPGGSKTDPLNIEIELTENPEEEKKRLGLLDPTTERSKKRKVEKDEKSEKPAENSPFKKLQKNQYNSPRKDSRRPPQLSKEEKSAAENRKQKTEYFNKKYRYGNFDRYYGIRLNPGESDKRLSVFQKDWFEHKQALDIGCNAGFLTLSIAKDFSPRRIIGIDIDEHLIGVARKNIRHYCDHETEVSGKFPASFGVQFGTVSQRNEAPRSFSTKFPDNIWFKKENYVLESDEMLDMIQPEFDVILALSITKWIHLNWGDDGMRRFFRRAYAQLHPGGRLIIEPQAFDSYKKRAKMSEELKANYSKIEFKPEDFEMWLIETVGFESVEKLGVVGAKSKGFERPIDVYLKPLHPKTDAIPLGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPI1</accession>
    <name>A0A078BPI1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TSC22 domain family protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C30G4.4</name>
        <name evidence="2" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294809.1">
        <property type="nucleotide sequence ID" value="NM_001307880.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPI1"/>
    <dbReference type="SMR" id="A0A078BPI1"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4i">
        <property type="protein sequence ID" value="CE50086"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPI1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C30G4.4i"/>
        </source>
    </evidence>
    <sequence length="233" mass="25518" checksum="2D6E751975D17F57" modified="2014-10-29" version="1">MSSGGSRFKQSESPINMLITHREMKCDMKSEPSLKVVPVETRDPYFSPNGKHAIAKPTAAIKNIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKRAPLVRAKTVVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPI4</accession>
    <name>A0A078BPI4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F38C2.1</name>
        <name evidence="2 4" type="ORF">F38C2.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294104.1">
        <property type="nucleotide sequence ID" value="NM_001307175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPI4"/>
    <dbReference type="SMR" id="A0A078BPI4"/>
    <dbReference type="GeneID" id="185459"/>
    <dbReference type="AGR" id="WB:WBGene00009535"/>
    <dbReference type="CTD" id="185459"/>
    <dbReference type="WormBase" id="F38C2.1c">
        <property type="protein sequence ID" value="CE49991"/>
        <property type="gene ID" value="WBGene00009535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009535">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPI4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664:SF9">
        <property type="entry name" value="DUF4440 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664">
        <property type="entry name" value="PROTEIN CBG16427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F38C2.1c"/>
        </source>
    </evidence>
    <sequence length="105" mass="11541" checksum="3C9FA677AD23BAF5" modified="2014-10-29" version="1">MSNEAEALLKLQFDKYAKFIDDEVWAEVEGYYHPSGVLVHKGKEAVYGNKDKSTYIAKFAEGTGKSVGTTTNAKYEGSGDYLIITADFSSETEKAGTVKGRFVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPI6</accession>
    <name>A0A078BPI6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TSC22 domain family protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C30G4.4</name>
        <name evidence="2" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294814.1">
        <property type="nucleotide sequence ID" value="NM_001307885.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPI6"/>
    <dbReference type="SMR" id="A0A078BPI6"/>
    <dbReference type="PaxDb" id="6239-C30G4.7"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4n">
        <property type="protein sequence ID" value="CE50095"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPI6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C30G4.4n"/>
        </source>
    </evidence>
    <sequence length="198" mass="21497" checksum="1E6E7063464D5329" modified="2014-10-29" version="1">MSSGGSRFKVVPVETRDPYFSPNGKHAIAKPTAAIKNIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKSVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPI8</accession>
    <name>A0A078BPI8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leprecan-like alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y73F8A.26</name>
        <name evidence="4 6" type="ORF">Y73F8A.26</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294109.1">
        <property type="nucleotide sequence ID" value="NM_001307180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPI8"/>
    <dbReference type="SMR" id="A0A078BPI8"/>
    <dbReference type="GeneID" id="178435"/>
    <dbReference type="KEGG" id="cel:CELE_Y73F8A.26"/>
    <dbReference type="AGR" id="WB:WBGene00013531"/>
    <dbReference type="CTD" id="178435"/>
    <dbReference type="WormBase" id="Y73F8A.26b">
        <property type="protein sequence ID" value="CE50003"/>
        <property type="gene ID" value="WBGene00013531"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8517835at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013531">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPI8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052284">
        <property type="entry name" value="Collagen_mod_leprecan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056585">
        <property type="entry name" value="Leprecan_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986:SF8">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986">
        <property type="entry name" value="PROTEIN LYSINE HYDROXYLATION COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23557">
        <property type="entry name" value="TPR_leprecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Leprecan-like alpha-helical" evidence="3">
        <location>
            <begin position="11"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDX47476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y73F8A.26b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BPI8"/>
        </source>
    </evidence>
    <sequence length="375" mass="44064" checksum="2DB13B8131974DD8" modified="2014-10-29" version="1">MFGDHQSIKKMSVYHDLEERKPYQYMHICYYHQGELAMAVQSAYTFLVANPDDKDIKQSLNWYMNRDGYSDDMLIDMERKDHEAKFINGVEAYDQQDWGRCVNEFESALEKSIIQDEKCRLLCQDKIDWSVVDGNPEIDILLASMRASVIRCEHNCLYKLARINGHYVGHLFAAHFEYLHFCHFKMQRGAEAAQTVANYLLFDDSPLMRRNRYFYGKQYKKNELFTPSQEVLDIYRRRDLEARFLEFMEKRFVVKDGELPPEQADDRNPLSLDIHVEDNFPYEQIPSLMTSSECKILRSALDTRERDGFVKELEQRVKLWPNSSYSNVTCGSPVREAQCSRAIVFSAEHNDCGEWLGKWFNGCAVVFCDEKKIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPJ1</accession>
    <name>A0A078BPJ1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TSC22 domain family protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C30G4.4</name>
        <name evidence="2" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294819.1">
        <property type="nucleotide sequence ID" value="NM_001307890.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPJ1"/>
    <dbReference type="SMR" id="A0A078BPJ1"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4s">
        <property type="protein sequence ID" value="CE50109"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPJ1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C30G4.4s"/>
        </source>
    </evidence>
    <sequence length="56" mass="6596" checksum="1C852AFFC2A82810" modified="2014-10-29" version="1">MDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPJ4</accession>
    <name>A0A078BPJ4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">InTestinal NeureXin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">itx-1</name>
        <name evidence="7" type="ORF">CELE_W03D8.6</name>
        <name evidence="9" type="ORF">W03D8.6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293384.1">
        <property type="nucleotide sequence ID" value="NM_001306455.3"/>
    </dbReference>
    <dbReference type="GeneID" id="171846"/>
    <dbReference type="AGR" id="WB:WBGene00002174"/>
    <dbReference type="CTD" id="171846"/>
    <dbReference type="WormBase" id="W03D8.6e">
        <property type="protein sequence ID" value="CE50118"/>
        <property type="gene ID" value="WBGene00002174"/>
        <property type="gene designation" value="itx-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5989513at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002174">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPJ4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:001029">
        <property type="entry name" value="InTestinal NeureXin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000341">
        <property type="entry name" value="InTestinal NeureXin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF94">
        <property type="entry name" value="INTESTINAL NEUREXIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1261"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="302"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="531"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="691"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="735"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="1001"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1404"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDX47481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="W03D8.6e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BPJ4"/>
        </source>
    </evidence>
    <sequence length="1453" mass="161903" checksum="D95A62D3E1C3A8A3" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPJ6</accession>
    <name>A0A078BPJ6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_Y105C5A.15</name>
        <name evidence="7 9" type="ORF">Y105C5A.15</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294100.1">
        <property type="nucleotide sequence ID" value="NM_001307171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPJ6"/>
    <dbReference type="GeneID" id="178442"/>
    <dbReference type="AGR" id="WB:WBGene00013639"/>
    <dbReference type="CTD" id="178442"/>
    <dbReference type="WormBase" id="Y105C5A.15e">
        <property type="protein sequence ID" value="CE49994"/>
        <property type="gene ID" value="WBGene00013639"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1607513at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013639">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPJ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF29">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="6">
        <location>
            <begin position="242"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDX47462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y105C5A.15e"/>
        </source>
    </evidence>
    <sequence length="856" mass="94972" checksum="3C21468523B9BE1C" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPK0</accession>
    <name>A0A078BPK0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase FkbM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y40H7A.4</name>
        <name evidence="2 4" type="ORF">Y40H7A.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294114.1">
        <property type="nucleotide sequence ID" value="NM_001307185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPK0"/>
    <dbReference type="GeneID" id="189803"/>
    <dbReference type="AGR" id="WB:WBGene00012744"/>
    <dbReference type="CTD" id="189803"/>
    <dbReference type="WormBase" id="Y40H7A.4c">
        <property type="protein sequence ID" value="CE50115"/>
        <property type="gene ID" value="WBGene00012744"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5815019at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012744">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPK0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF5">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y40H7A.4c"/>
        </source>
    </evidence>
    <sequence length="131" mass="15302" checksum="DF4D838084EEC2A4" modified="2014-10-29" version="1">MNTLRIFSTLKSHVYVGMIPDNLTIAHIMHSEYKTEVEILKIDIEGGEHTGLEQFLRDFFVCQILIEIHGWPPEHLDMLQKISRYGFRIFNIEPNRLCTRCAEYSFINELCMSQYSVLPLANMIPRNLTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPK5</accession>
    <name>A0A078BPK5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">dlc-4</name>
        <name evidence="2" type="ORF">CELE_Y10G11A.3</name>
        <name evidence="4" type="ORF">Y10G11A.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294115.1">
        <property type="nucleotide sequence ID" value="NM_001307186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPK5"/>
    <dbReference type="SMR" id="A0A078BPK5"/>
    <dbReference type="GeneID" id="3565151"/>
    <dbReference type="AGR" id="WB:WBGene00012425"/>
    <dbReference type="CTD" id="3565151"/>
    <dbReference type="WormBase" id="Y10G11A.3b">
        <property type="protein sequence ID" value="CE50114"/>
        <property type="gene ID" value="WBGene00012425"/>
        <property type="gene designation" value="dlc-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012425">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPK5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21450">
        <property type="entry name" value="DLC-like_DYNLL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000006">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF88">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y10G11A.3b"/>
        </source>
    </evidence>
    <sequence length="111" mass="13005" checksum="947BBCEAC30B2597" modified="2014-10-29" version="1">MLAIARKKLSIRRKESRKWREPPEKALRFENVIIQETNLPFEQVEESKKMLGDALQLCGIENEIASFMKRKFDAKYGGHWQCVVGRNFGSHLDPIQFIHFTVSKISVILFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPK7</accession>
    <name>A0A078BPK7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">ntl-11</name>
        <name evidence="1" type="ORF">CELE_Y73F8A.25</name>
        <name evidence="3" type="ORF">Y73F8A.25</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDX47475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294108.1">
        <property type="nucleotide sequence ID" value="NM_001307179.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPK7"/>
    <dbReference type="SMR" id="A0A078BPK7"/>
    <dbReference type="GeneID" id="178432"/>
    <dbReference type="AGR" id="WB:WBGene00013530"/>
    <dbReference type="CTD" id="178432"/>
    <dbReference type="WormBase" id="Y73F8A.25f">
        <property type="protein sequence ID" value="CE50012"/>
        <property type="gene ID" value="WBGene00013530"/>
        <property type="gene designation" value="ntl-11"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013530">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPK7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDX47475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y73F8A.25f"/>
        </source>
    </evidence>
    <sequence length="75" mass="8243" checksum="C28C689625AF65F3" modified="2014-10-29" version="1">MCLICSFVNSAAAPIIASGPSSNFSIISSKSDTHTVVQAFESSKDVKKGVFQRFFVPENAEKGENRKKIDKFDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPL3</accession>
    <name>A0A078BPL3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">InTestinal NeureXin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">itx-1</name>
        <name evidence="7" type="ORF">CELE_W03D8.6</name>
        <name evidence="9" type="ORF">W03D8.6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293383.1">
        <property type="nucleotide sequence ID" value="NM_001306454.3"/>
    </dbReference>
    <dbReference type="GeneID" id="171846"/>
    <dbReference type="AGR" id="WB:WBGene00002174"/>
    <dbReference type="CTD" id="171846"/>
    <dbReference type="WormBase" id="W03D8.6d">
        <property type="protein sequence ID" value="CE50017"/>
        <property type="gene ID" value="WBGene00002174"/>
        <property type="gene designation" value="itx-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5989513at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002174">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPL3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        </source>
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</entry>
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        </source>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
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    <sequence length="334" mass="38991" checksum="B02CDE1ED1A9D7C2" modified="2014-10-29" version="1">MHTSPNCTAAVLESIATSKQGSYIFLEIFGVLMCVFSVPLTYYSCECFEKERVQMHLKILMYFHHIALIMYSLSYISLGTYHLLSRLVFDGCDLLVPIDICIWVRIFQSFSSIFFQLFYIAVVLNTFMAKFQFWRSNENFVRGVAYFCAFFSIFEPLPSVYKDIQRDGHQLNCSSFEHKDALVQKNIFIGFLTLDFGSAIGFCIAMILQKRDMKDPVLKFNITKKHREMELHRTLILIFPNLILNMFCYVYFAGISMRWAAENQLDGNAFLVANSVPVYVFFSPIMWMITLRRWKGRVNPAPIEPDDYWKILTDTWNQKPIGKCILLNNRHGTR</sequence>
</entry>
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    <accession>A0A078BPM1</accession>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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    <dbReference type="CTD" id="178451"/>
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        <property type="protein sequence ID" value="CE50030"/>
        <property type="gene ID" value="WBGene00002175"/>
        <property type="gene designation" value="jac-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002175">
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    </dbReference>
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        <property type="entry name" value="Bent, isoform J"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
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            <begin position="145"/>
            <end position="241"/>
        </location>
    </feature>
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            <end position="348"/>
        </location>
    </feature>
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            <begin position="360"/>
            <end position="454"/>
        </location>
    </feature>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2004" name="EMBO J." volume="23" first="2226" last="2234">
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        <citation type="journal article" date="2010" name="Mol. Cell. Biol." volume="30" first="995" last="1003">
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        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="10738" last="10743">
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            <title>Endocannabinoid-Goalpha signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqalpha-PKC-JNK signalling.</title>
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            <title>The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade.</title>
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    <reference evidence="3" key="4">
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        <citation type="journal article" date="2012" name="Nat. Commun." volume="3" first="1136" last="1136">
            <title>Endocannabinoid-Goalpha signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqalpha-PKC-JNK signalling.</title>
            <authorList>
                <person name="Pastuhov S.I."/>
                <person name="Fujiki K."/>
                <person name="Nix P."/>
                <person name="Kanao S."/>
                <person name="Bastiani M."/>
                <person name="Matsumoto K."/>
                <person name="Hisamoto N."/>
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            <dbReference type="PubMed" id="23072806"/>
            <dbReference type="DOI" id="10.1038/ncomms2136"/>
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        <scope>ACTIVITY REGULATION</scope>
        <scope>INTERACTION WITH TPA-1</scope>
        <scope>PHOSPHORYLATION AT SER-355</scope>
        <scope>MUTAGENESIS OF SER-355</scope>
    </reference>
    <reference evidence="3" key="7">
        <citation type="journal article" date="2012" name="Nat. Neurosci." volume="15" first="551" last="557">
            <title>The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade.</title>
            <authorList>
                <person name="Li C."/>
                <person name="Hisamoto N."/>
                <person name="Nix P."/>
                <person name="Kanao S."/>
                <person name="Mizuno T."/>
                <person name="Bastiani M."/>
                <person name="Matsumoto K."/>
            </authorList>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>INTERACTION WITH SVH-2</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006475" last="E1006475">
            <title>The C. elegans discoidin domain receptor DDR-2 modulates the Met-like RTK-JNK signaling pathway in axon regeneration.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Nagamori Y."/>
                <person name="Shimizu T."/>
                <person name="Pastuhov S.I."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="27984580"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006475"/>
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        <scope>PHOSPHORYLATION</scope>
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            <id>A0A0K3AV08-2</id>
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        <source>
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    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CTQ86850.1"/>
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    <evidence type="ECO:0000312" key="5">
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    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="K11D12.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K11D12.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="K11D12.10c"/>
        </source>
    </evidence>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2004" name="EMBO J." volume="23" first="2226" last="2234">
            <title>The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response.</title>
            <authorList>
                <person name="Mizuno T."/>
                <person name="Hisamoto N."/>
                <person name="Terada T."/>
                <person name="Kondo T."/>
                <person name="Adachi M."/>
                <person name="Nishida E."/>
                <person name="Kim D.H."/>
                <person name="Ausubel F.M."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="15116070"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600226"/>
        </citation>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>MUTAGENESIS OF GLY-253</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2008" name="Mol. Cell. Biol." volume="28" first="7041" last="7049">
            <title>Role of the Caenorhabditis elegans Shc adaptor protein in the c-Jun N-terminal kinase signaling pathway.</title>
            <authorList>
                <person name="Mizuno T."/>
                <person name="Fujiki K."/>
                <person name="Sasakawa A."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="18809575"/>
            <dbReference type="DOI" id="10.1128/MCB.00938-08"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SHC-1</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MOTIF</scope>
        <scope>PHOSPHORYLATION AT TYR-940</scope>
        <scope>MUTAGENESIS OF TYR-940</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2010" name="Mol. Cell. Biol." volume="30" first="995" last="1003">
            <title>The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response.</title>
            <authorList>
                <person name="Fujiki K."/>
                <person name="Mizuno T."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="20008556"/>
            <dbReference type="DOI" id="10.1128/MCB.01131-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>INTERACTION WITH MAX-2</scope>
        <scope>PHOSPHORYLATION AT SER-355</scope>
        <scope>MUTAGENESIS OF LYS-193 AND SER-355</scope>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="10738" last="10743">
            <title>Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways.</title>
            <authorList>
                <person name="Nix P."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
                <person name="Bastiani M."/>
            </authorList>
            <dbReference type="PubMed" id="21670305"/>
            <dbReference type="DOI" id="10.1073/pnas.1104830108"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>UBIQUITINATION</scope>
    </reference>
    <reference evidence="3" key="6">
        <citation type="journal article" date="2012" name="Nat. Commun." volume="3" first="1136" last="1136">
            <title>Endocannabinoid-Goalpha signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqalpha-PKC-JNK signalling.</title>
            <authorList>
                <person name="Pastuhov S.I."/>
                <person name="Fujiki K."/>
                <person name="Nix P."/>
                <person name="Kanao S."/>
                <person name="Bastiani M."/>
                <person name="Matsumoto K."/>
                <person name="Hisamoto N."/>
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            <dbReference type="PubMed" id="23072806"/>
            <dbReference type="DOI" id="10.1038/ncomms2136"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>INTERACTION WITH TPA-1</scope>
        <scope>PHOSPHORYLATION AT SER-355</scope>
        <scope>MUTAGENESIS OF SER-355</scope>
    </reference>
    <reference evidence="3" key="7">
        <citation type="journal article" date="2012" name="Nat. Neurosci." volume="15" first="551" last="557">
            <title>The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade.</title>
            <authorList>
                <person name="Li C."/>
                <person name="Hisamoto N."/>
                <person name="Nix P."/>
                <person name="Kanao S."/>
                <person name="Mizuno T."/>
                <person name="Bastiani M."/>
                <person name="Matsumoto K."/>
            </authorList>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>INTERACTION WITH SVH-2</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006475" last="E1006475">
            <title>The C. elegans discoidin domain receptor DDR-2 modulates the Met-like RTK-JNK signaling pathway in axon regeneration.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Nagamori Y."/>
                <person name="Shimizu T."/>
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            </authorList>
            <dbReference type="PubMed" id="27984580"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006475"/>
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        <scope>PHOSPHORYLATION</scope>
    </reference>
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            <id>A0A0K3AV08-4</id>
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    <dbReference type="WormBase" id="K11D12.10d">
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        <source>
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    </evidence>
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    <evidence type="ECO:0000312" key="4">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <submittedName>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
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    </reference>
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        <location>
            <begin position="17"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="55"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="SAP35570.1"/>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
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    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH2190574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F48E3.8h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4QFG5"/>
        </source>
    </evidence>
    <sequence length="1726" mass="188952" checksum="67B5D1EC8382361F" modified="2022-10-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>E0R7K3</accession>
    <name>E0R7K3_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">DUF904 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y113G7B.27</name>
        <name evidence="2 4" type="ORF">Y113G7B.27</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256901.1">
        <property type="nucleotide sequence ID" value="NM_001269972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0R7K3"/>
    <dbReference type="SMR" id="E0R7K3"/>
    <dbReference type="GeneID" id="13218745"/>
    <dbReference type="KEGG" id="cel:CELE_Y113G7B.27"/>
    <dbReference type="AGR" id="WB:WBGene00195241"/>
    <dbReference type="CTD" id="13218745"/>
    <dbReference type="WormBase" id="Y113G7B.27b">
        <property type="protein sequence ID" value="CE45362"/>
        <property type="gene ID" value="WBGene00195241"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2833505_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00195241">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBW48569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y113G7B.27b"/>
        </source>
    </evidence>
    <sequence length="38" mass="4800" checksum="BE8C018F4005BD35" modified="2010-11-02" version="1">MLDEYFENLHRRICEEARHLKEEIHATRRELNELFKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>E0R7K5</accession>
    <name>E0R7K5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y37H2A.10</name>
        <name evidence="2 4" type="ORF">Y37H2A.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256790.1">
        <property type="nucleotide sequence ID" value="NM_001269861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0R7K5"/>
    <dbReference type="GeneID" id="189633"/>
    <dbReference type="AGR" id="WB:WBGene00012570"/>
    <dbReference type="CTD" id="189633"/>
    <dbReference type="WormBase" id="Y37H2A.10b">
        <property type="protein sequence ID" value="CE45336"/>
        <property type="gene ID" value="WBGene00012570"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1788583_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012570">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0R7K5">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002601">
        <property type="entry name" value="C6_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01681">
        <property type="entry name" value="C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01048">
        <property type="entry name" value="C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C6" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBW48577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y37H2A.10b"/>
        </source>
    </evidence>
    <sequence length="81" mass="8611" checksum="7AE6FF7A34CF7B1D" modified="2010-11-02" version="1">MTPIQTPGTDANNCAILTLTCQGTPVDPLNNVYLIYYSDSKVPRDAGADSGTGSIQTVLTCVNGVWDKGGYEINEVECQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>E0R7K7</accession>
    <name>E0R7K7_CAEEL</name>
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        <submittedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="5 7" type="primary">nova-1</name>
        <name evidence="5" type="ORF">CELE_Y59A8B.10</name>
        <name evidence="7" type="ORF">Y59A8B.10</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256770.1">
        <property type="nucleotide sequence ID" value="NM_001269841.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0R7K7"/>
    <dbReference type="SMR" id="E0R7K7"/>
    <dbReference type="IntAct" id="E0R7K7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="E0R7K7"/>
    <dbReference type="GeneID" id="180183"/>
    <dbReference type="AGR" id="WB:WBGene00013347"/>
    <dbReference type="CTD" id="180183"/>
    <dbReference type="WormBase" id="Y59A8B.10b">
        <property type="protein sequence ID" value="CE45369"/>
        <property type="gene ID" value="WBGene00013347"/>
        <property type="gene designation" value="nova-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_6_1_1"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013347">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0R7K7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22436">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047276">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBW48583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y59A8B.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="E0R7K7"/>
        </source>
    </evidence>
    <sequence length="312" mass="31229" checksum="7A1640E65ECF3594" modified="2010-11-02" version="1">MAVIESIQDKIREKCADQGGSDAFDHKNTSRGAEIKIVMPNTSAGMVIGKSGANIKDIREQFGCQIQVYPKAGSVEAKTSLERVVTVAHDEASALLQAASRVLEKVASDPHHASEINKEDFGKGSGPSGSANSGPSGGGGGGGGGGQSNNNSSFSSVPAFNGGGGGGGGMNVGAAGFGGGGGQGYGGPQFGGQGGPQFGNGNNKYPMSGLGNNELLSFLDNLQSTLRTSGFNEQSVSEVMQAMQVLAKYNIMGLGLGLGVAAMAQMRTGQESQGMSANHGSAGFGDGYGQGGVQGGPQGPQGGGGDQSYWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>E0R7K8</accession>
    <name>E0R7K8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nova-1</name>
        <name evidence="2" type="ORF">CELE_Y59A8B.10</name>
        <name evidence="4" type="ORF">Y59A8B.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256771.1">
        <property type="nucleotide sequence ID" value="NM_001269842.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0R7K8"/>
    <dbReference type="PeptideAtlas" id="E0R7K8"/>
    <dbReference type="GeneID" id="180183"/>
    <dbReference type="AGR" id="WB:WBGene00013347"/>
    <dbReference type="CTD" id="180183"/>
    <dbReference type="WormBase" id="Y59A8B.10c">
        <property type="protein sequence ID" value="CE45342"/>
        <property type="gene ID" value="WBGene00013347"/>
        <property type="gene designation" value="nova-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_6_1_1"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013347">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0R7K8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBW48584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y59A8B.10c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="E0R7K8"/>
        </source>
    </evidence>
    <sequence length="61" mass="5984" checksum="9E6F70A654E52EC8" modified="2010-11-02" version="1">MGLGLGLGVAAMAQMRTGQESQGMSANHGSAGFGDGYGQGGVQGGPQGPQGGGGDQSYWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>E0R7L3</accession>
    <name>E0R7L3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y111B2A.12</name>
        <name evidence="4 6" type="ORF">Y111B2A.12</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CBW48562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0R7L3"/>
    <dbReference type="SMR" id="E0R7L3"/>
    <dbReference type="PeptideAtlas" id="E0R7L3"/>
    <dbReference type="AGR" id="WB:WBGene00013735"/>
    <dbReference type="WormBase" id="Y111B2A.12b">
        <property type="protein sequence ID" value="CE45370"/>
        <property type="gene ID" value="WBGene00013735"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_9_1"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013735">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0R7L3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBW48562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y111B2A.12b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="E0R7L3"/>
        </source>
    </evidence>
    <sequence length="224" mass="24336" checksum="86BB35EEF1218AD8" modified="2010-11-02" version="1">MPDGKRIMCGYSDGIVRLWLLREETSTHLYFHSPITAIDHHVTQTVAIIGTQSGTVNVVNTASPDNVLKKISLLPPPGVKSTTITAAGTAAMEEGRQEEEEDEDVGNCVESLAMAPSHPWFAVGRNDGTMCIYEMDSNSPRSIFQSNQMMAIVKVIWSMEGNAPYVTAGSIDGTIRIFDARDSSLVKELHNGGDEVLDVLVIQSNPHRFMTAGSGGIVRVFDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>E0R7L7</accession>
    <name>E0R7L7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine specific protein phosphatases domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">pph-5</name>
        <name evidence="5" type="ORF">CELE_Y39B6A.2</name>
        <name evidence="7" type="ORF">Y39B6A.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256850.1">
        <property type="nucleotide sequence ID" value="NM_001269921.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0R7L7"/>
    <dbReference type="SMR" id="E0R7L7"/>
    <dbReference type="PeptideAtlas" id="E0R7L7"/>
    <dbReference type="GeneID" id="180263"/>
    <dbReference type="KEGG" id="cel:CELE_Y39B6A.2"/>
    <dbReference type="AGR" id="WB:WBGene00012665"/>
    <dbReference type="CTD" id="180263"/>
    <dbReference type="WormBase" id="Y39B6A.2b">
        <property type="protein sequence ID" value="CE45307"/>
        <property type="gene ID" value="WBGene00012665"/>
        <property type="gene designation" value="pph-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_5_2_1"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012665">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0R7L7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045920">
        <property type="term" value="P:negative regulation of exocytosis"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033365">
        <property type="term" value="P:protein localization to organelle"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000299">
        <property type="entry name" value="Serine/threonine-protein phosphatase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBW48579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y39B6A.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="E0R7L7"/>
        </source>
    </evidence>
    <sequence length="117" mass="13072" checksum="D4F21781DE7F11E4" modified="2010-11-02" version="1">MCDLLWSDPQPINGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGDNLTPRFTPFDAVPHPKLPPMAYANSLFGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>E0R7L8</accession>
    <name>E0R7L8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y39B6A.5</name>
        <name evidence="2 4" type="ORF">Y39B6A.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW48580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256845.1">
        <property type="nucleotide sequence ID" value="NM_001269916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0R7L8"/>
    <dbReference type="PeptideAtlas" id="E0R7L8"/>
    <dbReference type="GeneID" id="180260"/>
    <dbReference type="AGR" id="WB:WBGene00012668"/>
    <dbReference type="CTD" id="180260"/>
    <dbReference type="WormBase" id="Y39B6A.5b">
        <property type="protein sequence ID" value="CE45367"/>
        <property type="gene ID" value="WBGene00012668"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2560381_0_0_1"/>
    <dbReference type="OrthoDB" id="10393294at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012668">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0R7L8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBW48580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y39B6A.5b"/>
        </source>
    </evidence>
    <sequence length="36" mass="4089" checksum="A59BDD378B5086F0" modified="2010-11-02" version="1">MIGAGRGHRVQNWKSSQGATDKSDQPQQQQHQDQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>E7FM69</accession>
    <name>E7FM69_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hormone-sensitive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hosl-1</name>
        <name evidence="7" type="ORF">C46C11.1</name>
        <name evidence="5" type="ORF">CELE_C46C11.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367667.1">
        <property type="nucleotide sequence ID" value="NM_001380950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E7FM69"/>
    <dbReference type="SMR" id="E7FM69"/>
    <dbReference type="ESTHER" id="caeel-C46C11.1">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="E7FM69"/>
    <dbReference type="GeneID" id="180737"/>
    <dbReference type="AGR" id="WB:WBGene00016704"/>
    <dbReference type="CTD" id="180737"/>
    <dbReference type="WormBase" id="C46C11.1b">
        <property type="protein sequence ID" value="CE39698"/>
        <property type="gene ID" value="WBGene00016704"/>
        <property type="gene designation" value="hosl-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010288_1_0_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016704">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E7FM69">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010468">
        <property type="entry name" value="HSL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06350">
        <property type="entry name" value="HSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hormone-sensitive lipase N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="345"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="798"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD67458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C46C11.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="E7FM69"/>
        </source>
    </evidence>
    <sequence length="908" mass="101494" checksum="687293F01197B35B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0V0</accession>
    <name>G1K0V0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 96</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C56E10.3</name>
        <name evidence="2" type="ORF">CELE_C56E10.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD65642.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359895.1">
        <property type="nucleotide sequence ID" value="NM_001373334.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0V0"/>
    <dbReference type="SMR" id="G1K0V0"/>
    <dbReference type="GeneID" id="183863"/>
    <dbReference type="AGR" id="WB:WBGene00016976"/>
    <dbReference type="CTD" id="183863"/>
    <dbReference type="WormBase" id="C56E10.3b">
        <property type="protein sequence ID" value="CE53201"/>
        <property type="gene ID" value="WBGene00016976"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514130_0_0_1"/>
    <dbReference type="OrthoDB" id="5805620at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016976">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0V0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="348"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65642.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C56E10.3b"/>
        </source>
    </evidence>
    <sequence length="528" mass="61471" checksum="19A529A90B28CB23" modified="2019-07-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0V7</accession>
    <name>G1K0V7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prothymosin alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_T05G5.1</name>
        <name evidence="3 5" type="ORF">T05G5.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCC42198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255019.1">
        <property type="nucleotide sequence ID" value="NM_001268090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0V7"/>
    <dbReference type="PeptideAtlas" id="G1K0V7"/>
    <dbReference type="GeneID" id="3565362"/>
    <dbReference type="AGR" id="WB:WBGene00011498"/>
    <dbReference type="CTD" id="3565362"/>
    <dbReference type="WormBase" id="T05G5.1b">
        <property type="protein sequence ID" value="CE46297"/>
        <property type="gene ID" value="WBGene00011498"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650896_0_0_1"/>
    <dbReference type="OrthoDB" id="5870055at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011498">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0V7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC42198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T05G5.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="G1K0V7"/>
        </source>
    </evidence>
    <sequence length="179" mass="20649" checksum="470FDFA3E824D867" modified="2011-10-19" version="1">MNEQFEYEGGDEEYPQVAEKEDEYDEGYETDNTEDVTITTTKTTKLMKPMVEESKGVDGDDGSDMIMEKDEMEDDKEPIRKEDEKLIDSIKHVFNKAVDETVKEHPIEEDEYWDETSKKTDEDSWTAENEGTKKTEEADEYGMEEGTEGWMMVKKENENAAVGTTVSLITVTFLFTLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0V8</accession>
    <name>G1K0V8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">iff-1</name>
        <name evidence="10" type="ORF">CELE_T05G5.10</name>
        <name evidence="12" type="ORF">T05G5.10</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCC42199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255021.1">
        <property type="nucleotide sequence ID" value="NM_001268092.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0V8"/>
    <dbReference type="SMR" id="G1K0V8"/>
    <dbReference type="PeptideAtlas" id="G1K0V8"/>
    <dbReference type="GeneID" id="176373"/>
    <dbReference type="KEGG" id="cel:CELE_T05G5.10"/>
    <dbReference type="AGR" id="WB:WBGene00002064"/>
    <dbReference type="CTD" id="176373"/>
    <dbReference type="WormBase" id="T05G5.10b">
        <property type="protein sequence ID" value="CE00503"/>
        <property type="gene ID" value="WBGene00002064"/>
        <property type="gene designation" value="iff-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_0_0_1"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="PhylomeDB" id="G1K0V8"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002064">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0V8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007276">
        <property type="term" value="P:gamete generation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC42199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="T05G5.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="G1K0V8"/>
        </source>
    </evidence>
    <sequence length="161" mass="17867" checksum="7BD03FAE52D6387C" modified="2011-10-19" version="1">MSEDHHDEEQFDSAESGAAATFPKQCSALRKNEHVMIRGRPCKIVEMSTSKTGKHGHAKVHMVAIDIFTTKKLEDICPSTHNMDVPVVKRREYILMSIEDGFCSLMDPESCELKDDLKMPEGDLGNTIREALEKDEGSVLVQVVAACGEEAILGYKISTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0V9</accession>
    <name>G1K0V9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation elongation factor IF5A C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">iff-1</name>
        <name evidence="5" type="ORF">CELE_T05G5.10</name>
        <name evidence="7" type="ORF">T05G5.10</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCC42200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255022.1">
        <property type="nucleotide sequence ID" value="NM_001268093.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0V9"/>
    <dbReference type="SMR" id="G1K0V9"/>
    <dbReference type="PeptideAtlas" id="G1K0V9"/>
    <dbReference type="GeneID" id="176373"/>
    <dbReference type="AGR" id="WB:WBGene00002064"/>
    <dbReference type="CTD" id="176373"/>
    <dbReference type="WormBase" id="T05G5.10c">
        <property type="protein sequence ID" value="CE46328"/>
        <property type="gene ID" value="WBGene00002064"/>
        <property type="gene designation" value="iff-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_0_0_1"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002064">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0V9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007276">
        <property type="term" value="P:gamete generation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0385">Hypusine</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC42200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="T05G5.10c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="G1K0V9"/>
        </source>
    </evidence>
    <sequence length="66" mass="7152" checksum="BB1B6BBCCFD2E481" modified="2011-10-19" version="1">MSIEDGFCSLMDPESCELKDDLKMPEGDLGNTIREALEKDEGSVLVQVVAACGEEAILGYKISTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0W1</accession>
    <name>G1K0W1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GDP-fucose protein O-fucosyltransferase 2</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Peptide-O-fucosyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">pad-2</name>
        <name evidence="20" type="ORF">CELE_K10G9.3</name>
        <name evidence="22" type="ORF">K10G9.3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCC42186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255069.1">
        <property type="nucleotide sequence ID" value="NM_001268140.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0W1"/>
    <dbReference type="SMR" id="G1K0W1"/>
    <dbReference type="PeptideAtlas" id="G1K0W1"/>
    <dbReference type="GeneID" id="259529"/>
    <dbReference type="AGR" id="WB:WBGene00010757"/>
    <dbReference type="CTD" id="259529"/>
    <dbReference type="WormBase" id="K10G9.3b">
        <property type="protein sequence ID" value="CE46519"/>
        <property type="gene ID" value="WBGene00010757"/>
        <property type="gene designation" value="pad-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033856_0_0_1"/>
    <dbReference type="OMA" id="RNAVWPI"/>
    <dbReference type="OrthoDB" id="422368at2759"/>
    <dbReference type="PhylomeDB" id="G1K0W1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010757">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0W1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11298">
        <property type="entry name" value="O-FucT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11340:FF:000007">
        <property type="entry name" value="GDP-fucose protein O-fucosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000002">
        <property type="entry name" value="GDP-fucose protein O-fucosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003412882" description="GDP-fucose protein O-fucosyltransferase 2" evidence="19">
        <location>
            <begin position="21"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCC42186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="K10G9.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="G1K0W1"/>
        </source>
    </evidence>
    <sequence length="426" mass="50336" checksum="96EE1E5870B686E8" modified="2011-10-19" version="1">MHFFPIQLLVLFFAEKIAFAENSDQTVSRVDSNRYSVAAEKKFLLYDVNFGEGFNLRRDVYMRVANTVRSLRDSGENYILVLPPWGRLHHWKRMEVALSWRLFFDLESLNRFIPVIEFEDFLDETENRPIDQVIYLQHYAEGWGTEYVRKFEKRSCLPPAESHYKQVEEFKWKGWFYSYEDVYSRNFQCVSIQGDSGTLKDLLKHSNFSESTSIMVDRAETILHEHYGEVDYWKARRSMRYSNDLVDVADAFRKKYLDSDDKRDKTKLVDDWTKEKPRRTAIGGPYLGIHWRRRDFLYARRAQLPTIPGTAKILQDLCKKLDLQKIYLATDAPDQEVDELKALLNGELEVYRFTDTQKLNDGQIAIIDQYLCAHAAYFIGSYESTFTFRIQEDREIIGFPISTTFNRLCPDTEPTCEQPAKWKIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0W2</accession>
    <name>G1K0W2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">mpz-1</name>
        <name evidence="5" type="ORF">C52A11.4</name>
        <name evidence="3" type="ORF">CELE_C52A11.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCC42158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254264.1">
        <property type="nucleotide sequence ID" value="NM_001267335.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0W2"/>
    <dbReference type="SMR" id="G1K0W2"/>
    <dbReference type="PeptideAtlas" id="G1K0W2"/>
    <dbReference type="GeneID" id="174657"/>
    <dbReference type="AGR" id="WB:WBGene00003404"/>
    <dbReference type="CTD" id="174657"/>
    <dbReference type="WormBase" id="C52A11.4j">
        <property type="protein sequence ID" value="CE46131"/>
        <property type="gene ID" value="WBGene00003404"/>
        <property type="gene designation" value="mpz-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000856_1_0_1"/>
    <dbReference type="OrthoDB" id="6022711at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003404">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0W2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd06673">
        <property type="entry name" value="PDZ10_MUPP1-PDZ8_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06674">
        <property type="entry name" value="PDZ11_MUPP1-PDZ9_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000038">
        <property type="entry name" value="Multiple PDZ domain protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000058">
        <property type="entry name" value="multiple PDZ domain protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="39"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="139"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="389"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC42158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C52A11.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="G1K0W2"/>
        </source>
    </evidence>
    <sequence length="470" mass="50188" checksum="C3818458FCEF3CFA" modified="2011-10-19" version="1">MPTTTEGIENAAPNQEELSRKKSFSQERTQAIENGRETMIEIDKDGKGLGLSIVGGADTVLGTVVIHEVYSDGAAAHDGRLKPGDQVLEVNGTSLRGVTHDQSIAYLRRTPPKVRLLIYRDVNLQLSLLDPTQIYNIFEIDLVKKTGRGLGISIVGRKNEPGVYVSEIVKGGLAESDGRLMTGDQILEVNGKDVRGCMQEDVAAMLKTITGKVHLKLGRWKITETANRVHAATQALAKSATTPRTTENNNDPVRPVAVAVSSPAATPSTSASVTVTSAPATSVPEPNVVVEPIPGPTSAREERNDVPPPAPPMRPIITHTSPEGCETQQEPAGLSPVTEEPSSGCDFMSVQEEEQPRTPTTTTSSSNNNNSLAIDIIHDLKEEGSDTLLVELKKVVDQQLGMGIGKRSRGILVTSLQPGSAAAEKLKVGDRILAVNALPVSDQLSAVTFVKASGQRLYLQIARPHSIPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0W3</accession>
    <name>G1K0W3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">mpz-1</name>
        <name evidence="5" type="ORF">C52A11.4</name>
        <name evidence="3" type="ORF">CELE_C52A11.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCC42159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254263.1">
        <property type="nucleotide sequence ID" value="NM_001267334.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0W3"/>
    <dbReference type="SMR" id="G1K0W3"/>
    <dbReference type="PeptideAtlas" id="G1K0W3"/>
    <dbReference type="GeneID" id="174657"/>
    <dbReference type="AGR" id="WB:WBGene00003404"/>
    <dbReference type="CTD" id="174657"/>
    <dbReference type="WormBase" id="C52A11.4i">
        <property type="protein sequence ID" value="CE46169"/>
        <property type="gene ID" value="WBGene00003404"/>
        <property type="gene designation" value="mpz-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000856_1_0_1"/>
    <dbReference type="OrthoDB" id="6022711at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003404">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0W3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd06673">
        <property type="entry name" value="PDZ10_MUPP1-PDZ8_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06674">
        <property type="entry name" value="PDZ11_MUPP1-PDZ9_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06671">
        <property type="entry name" value="PDZ7_MUPP1-PD6_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000269">
        <property type="entry name" value="Multiple PDZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000038">
        <property type="entry name" value="Multiple PDZ domain protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="388"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="549"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="649"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="899"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC42159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C52A11.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="G1K0W3"/>
        </source>
    </evidence>
    <sequence length="980" mass="105529" checksum="0F7D9C9FC1722F36" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0W4</accession>
    <name>G1K0W4_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">mpz-1</name>
        <name evidence="5" type="ORF">C52A11.4</name>
        <name evidence="3" type="ORF">CELE_C52A11.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCC42160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254262.1">
        <property type="nucleotide sequence ID" value="NM_001267333.3"/>
    </dbReference>
    <dbReference type="SMR" id="G1K0W4"/>
    <dbReference type="PeptideAtlas" id="G1K0W4"/>
    <dbReference type="GeneID" id="174657"/>
    <dbReference type="AGR" id="WB:WBGene00003404"/>
    <dbReference type="CTD" id="174657"/>
    <dbReference type="WormBase" id="C52A11.4h">
        <property type="protein sequence ID" value="CE46289"/>
        <property type="gene ID" value="WBGene00003404"/>
        <property type="gene designation" value="mpz-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022711at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003404">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0W4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd06673">
        <property type="entry name" value="PDZ10_MUPP1-PDZ8_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06674">
        <property type="entry name" value="PDZ11_MUPP1-PDZ9_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06670">
        <property type="entry name" value="PDZ6_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06671">
        <property type="entry name" value="PDZ7_MUPP1-PD6_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000269">
        <property type="entry name" value="Multiple PDZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000038">
        <property type="entry name" value="Multiple PDZ domain protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF96">
        <property type="entry name" value="FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="463"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="817"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1328"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
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        <location>
            <begin position="1199"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC42160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C52A11.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="G1K0W4"/>
        </source>
    </evidence>
    <sequence length="1409" mass="152394" checksum="B656E7B98106867D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0W6</accession>
    <name>G1K0W6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial fission factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F11C1.7</name>
        <name evidence="2 4" type="ORF">F11C1.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango11 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCC42165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257209.1">
        <property type="nucleotide sequence ID" value="NM_001270280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0W6"/>
    <dbReference type="SMR" id="G1K0W6"/>
    <dbReference type="GeneID" id="6418845"/>
    <dbReference type="AGR" id="WB:WBGene00045495"/>
    <dbReference type="CTD" id="6418845"/>
    <dbReference type="WormBase" id="F11C1.7c">
        <property type="protein sequence ID" value="CE46336"/>
        <property type="gene ID" value="WBGene00045495"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1918930_0_0_1"/>
    <dbReference type="OrthoDB" id="5817180at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00045495">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K0W6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008518">
        <property type="entry name" value="Mff/Tango-11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16501:SF19">
        <property type="entry name" value="MITOCHONDRIAL FISSION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16501">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="1" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC42165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F11C1.7c"/>
        </source>
    </evidence>
    <sequence length="135" mass="15337" checksum="1AACC17CCCE26FF5" modified="2011-10-19" version="1">MYMPEHISGTGDAMSMTGMENFSNPATNPTDDQRKIEAGHDHFFIPEEAVGSIYESADYMAIMDKFADHFHSDVEAHCETDPVRQIKTVRTQLRDITHTLDKLLEDNAKRDRREQFIWAGLAGLALVTLISLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>G1K0X0</accession>
    <name>G1K0X0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-GlycoProtein related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">pgp-6</name>
        <name evidence="11" type="ORF">CELE_T21E8.1</name>
        <name evidence="13" type="ORF">T21E8.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCC42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257118.1">
        <property type="nucleotide sequence ID" value="NM_001270189.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K0X0"/>
    <dbReference type="SMR" id="G1K0X0"/>
    <dbReference type="PeptideAtlas" id="G1K0X0"/>
    <dbReference type="GeneID" id="181278"/>
    <dbReference type="AGR" id="WB:WBGene00004000"/>
    <dbReference type="CTD" id="181278"/>
    <dbReference type="WormBase" id="T21E8.1c">
        <property type="protein sequence ID" value="CE46295"/>
        <property type="gene ID" value="WBGene00004000"/>
        <property type="gene designation" value="pgp-6"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004000">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2005" name="Biochem. Biophys. Res. Commun." volume="330" first="967" last="974">
            <title>Molecular characterization of two G protein-coupled receptor splice variants as FLP2 receptors in Caenorhabditis elegans.</title>
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                <person name="Mertens I."/>
                <person name="Meeusen T."/>
                <person name="Janssen T."/>
                <person name="Nachman R."/>
                <person name="Schoofs L."/>
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        <citation type="journal article" date="2013" name="Int. J. Parasitol. Drugs Drug Resist." volume="3" first="1" last="7">
            <title>Functional expression and characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in mammalian cells and yeast.</title>
            <authorList>
                <person name="Larsen M.J."/>
                <person name="Lancheros E.R."/>
                <person name="Williams T."/>
                <person name="Lowery D.E."/>
                <person name="Geary T.G."/>
                <person name="Kubiak T.M."/>
            </authorList>
            <dbReference type="PubMed" id="24533288"/>
            <dbReference type="DOI" id="10.1016/j.ijpddr.2012.10.002"/>
        </citation>
        <scope>FUNCTION</scope>
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        <citation type="journal article" date="2016" name="Genetics" volume="204" first="1151" last="1159">
            <title>The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion.</title>
            <authorList>
                <person name="Chen D."/>
                <person name="Taylor K.P."/>
                <person name="Hall Q."/>
                <person name="Kaplan J.M."/>
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            <dbReference type="PubMed" id="27585848"/>
            <dbReference type="DOI" id="10.1534/genetics.116.192898"/>
        </citation>
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        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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        <isoform>
            <id>G5EEB1-2</id>
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        </isoform>
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            <dbReference type="PubMed" id="15809090"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T19F4.1a"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="T19F4.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T19F4.1c"/>
        </source>
    </evidence>
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</entry>
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    <accession>G5EEB1-3</accession>
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        <recommendedName>
            <fullName evidence="5">Isoform c of FMRFamide peptide receptor frpr-18</fullName>
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    <gene>
        <name evidence="5" type="primary">frpr-18</name>
        <name evidence="5" type="ORF">T19F4.1</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2005" name="Biochem. Biophys. Res. Commun." volume="330" first="967" last="974">
            <title>Molecular characterization of two G protein-coupled receptor splice variants as FLP2 receptors in Caenorhabditis elegans.</title>
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                <person name="Mertens I."/>
                <person name="Meeusen T."/>
                <person name="Janssen T."/>
                <person name="Nachman R."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="15809090"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2005.03.071"/>
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        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2013" name="Int. J. Parasitol. Drugs Drug Resist." volume="3" first="1" last="7">
            <title>Functional expression and characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in mammalian cells and yeast.</title>
            <authorList>
                <person name="Larsen M.J."/>
                <person name="Lancheros E.R."/>
                <person name="Williams T."/>
                <person name="Lowery D.E."/>
                <person name="Geary T.G."/>
                <person name="Kubiak T.M."/>
            </authorList>
            <dbReference type="PubMed" id="24533288"/>
            <dbReference type="DOI" id="10.1016/j.ijpddr.2012.10.002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2016" name="Genetics" volume="204" first="1151" last="1159">
            <title>The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion.</title>
            <authorList>
                <person name="Chen D."/>
                <person name="Taylor K.P."/>
                <person name="Hall Q."/>
                <person name="Kaplan J.M."/>
            </authorList>
            <dbReference type="PubMed" id="27585848"/>
            <dbReference type="DOI" id="10.1534/genetics.116.192898"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
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            <id>G5EEB1-3</id>
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        </isoform>
        <isoform>
            <id>G5EEB1-2</id>
            <name evidence="4">a</name>
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        </isoform>
        <isoform>
            <id>G5EEB1-1</id>
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        </isoform>
    </comment>
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        <property type="gene designation" value="frpr-18"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T19F4.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T19F4.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T19F4.1c"/>
        </source>
    </evidence>
    <sequence length="369" mass="42411" checksum="9C90BD0848E337DF" modified="2011-12-14" version="1">MESQQLMACAILVIVLVGIFGNSLSFILFSRPHMRSSSVNVLLCALSFFDFSLLTLSIPIFVIPNLDLWANDLSLSTYMAYILKLIYPINLMMQTCSVYIMVMITLERWVAVCRPLQVRVWCTPRKSRNAILVIIVSAFLYNFVRFFEYRFVVTESGALYEKWLRDPGKHRWYYVGYYTILYIVTHFLVPFSVMAFANGHVIVAMCKLSKTRQMLTRQSTRGLAYWLNDLSNLLVVLNSGTTFIIYFTFSEKYRQTLVFILKNGCCATVSDYNNYTAMSRTASMRISSETGGQIQRQGSKMSNSSYRKPILNAHLSEPLIGRSSQTNLHAEKKRTLLVGVQRTNLQTPCSFRRAQITKIAEREEEEETT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-02-04" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>G5EFZ1-2</accession>
    <name>GPMI_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform b of 2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="3">iPGM</shortName>
            <ecNumber evidence="1 2">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ipgm-1</name>
        <name evidence="8" type="ORF">F57B10.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="37185" last="37190">
            <title>Cofactor-independent phosphoglycerate mutase has an essential role in Caenorhabditis elegans and is conserved in parasitic nematodes.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Foster J.M."/>
                <person name="Kumar S."/>
                <person name="Fougere M."/>
                <person name="Carlow C.K."/>
            </authorList>
            <dbReference type="PubMed" id="15234973"/>
            <dbReference type="DOI" id="10.1074/jbc.M405877200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2007" name="Mol. Biochem. Parasitol." volume="156" first="210" last="216">
            <title>Molecular and biochemical characterization of nematode cofactor independent phosphoglycerate mutases.</title>
            <authorList>
                <person name="Raverdy S."/>
                <person name="Zhang Y."/>
                <person name="Foster J."/>
                <person name="Carlow C.K."/>
            </authorList>
            <dbReference type="PubMed" id="17897734"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2007.08.002"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EFZ1-1</id>
            <name evidence="8">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EFZ1-2</id>
            <name evidence="9">b</name>
            <sequence type="described" ref="VSP_057382"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="1 2"/>
    <dbReference type="RefSeq" id="NP_871851.1">
        <property type="nucleotide sequence ID" value="NM_182051.6"/>
    </dbReference>
    <dbReference type="WormBase" id="F57B10.3b">
        <property type="protein sequence ID" value="CE33113"/>
        <property type="gene ID" value="WBGene00019001"/>
        <property type="gene designation" value="ipgm-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="15234973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="17897734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="15234973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="15234973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="AAT01444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="F57B10.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="F57B10.3b"/>
        </source>
    </evidence>
    <sequence length="521" mass="57110" checksum="D13B64A84C99EC83" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1997-07-01" modified="2025-10-08" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>O01607</accession>
    <name>O01607_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">acdh-4</name>
        <name evidence="10" type="ORF">CELE_T10E9.9</name>
        <name evidence="12" type="ORF">T10E9.9</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD68108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T25885">
        <property type="entry name" value="T25885"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491886.2">
        <property type="nucleotide sequence ID" value="NM_059485.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O01607"/>
    <dbReference type="SMR" id="O01607"/>
    <dbReference type="PaxDb" id="6239-T10E9.9"/>
    <dbReference type="PeptideAtlas" id="O01607"/>
    <dbReference type="GeneID" id="172367"/>
    <dbReference type="UCSC" id="T10E9.9">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020419"/>
    <dbReference type="CTD" id="172367"/>
    <dbReference type="WormBase" id="T10E9.9a">
        <property type="protein sequence ID" value="CE34367"/>
        <property type="gene ID" value="WBGene00020419"/>
        <property type="gene designation" value="acdh-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_0_1"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="PhylomeDB" id="O01607"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020419">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O01607">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000086">
        <property type="entry name" value="Acyl CoA DeHydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000026">
        <property type="entry name" value="Acyl-CoA dehydrogenase medium chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF17">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="91"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="198"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD68108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="T10E9.9a"/>
        </source>
    </evidence>
    <sequence length="319" mass="35040" checksum="72BD7F1A0412351A" modified="2003-10-01" version="3">MDRTSEMTPAVINGCFENGLMGIEVPEKYGGPGATFFDAALVIEEISKVDASVGAMVDVHNTLFIPLIIELGTEKQKEKYLPKCYTSSVGSFALSETGSGSDAFALKTTAKKDGDDYVINGSKMWISNSEQSETFLVFANADPSKGYKGITCFIVEKGTKGFTIGKHEDKLGVRSSSTCPLHFDNVRVHKSAILGEFGKGYKYAIEYLNAGRIGIGAQMLGLAQGCFDQTIPYLQQREQFGQRIIDFQGMQHQIAQVRTEIEAARLLVYNAARMKQHGLPFVREAAMAKLFASPKNSPSRNTIVTVKLERFTKELPTFN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-28" modified="2026-01-28" version="206" xmlns="https://uniprot.org/uniprot">
    <accession>O01761-2</accession>
    <name>UNC89_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Muscle M-line assembly protein unc-89</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Inactive serine/threonine-protein kinase unc-89</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Obscurin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Uncoordinated protein 89</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">unc-89</name>
        <name type="ORF">C09D1.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="1996" name="J. Cell Biol." volume="132" first="835" last="848">
            <title>The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="Tinley T.L."/>
                <person name="Tang X."/>
                <person name="Borodovsky M."/>
            </authorList>
            <dbReference type="PubMed" id="8603916"/>
            <dbReference type="DOI" id="10.1083/jcb.132.5.835"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Structure" volume="8" first="1079" last="1087">
            <title>Structure of a PH domain from the C. elegans muscle protein UNC-89 suggests a novel function.</title>
            <authorList>
                <person name="Blomberg N."/>
                <person name="Baraldi E."/>
                <person name="Sattler M."/>
                <person name="Saraste M."/>
                <person name="Nilges M."/>
            </authorList>
            <dbReference type="PubMed" id="11080629"/>
            <dbReference type="DOI" id="10.1016/S0969-2126(00)00509-8"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 341-458</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="J. Mol. Biol." volume="342" first="91" last="108">
            <title>Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains.</title>
            <authorList>
                <person name="Small T.M."/>
                <person name="Gernert K.M."/>
                <person name="Flaherty D.B."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
                <person name="Benian G.M."/>
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            <dbReference type="DOI" id="10.1016/j.jmb.2004.07.006"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 5922-7990 (ISOFORMS B/F)</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="J. Muscle Res. Cell Motil." volume="26" first="435" last="447">
            <title>Titin/connectin-related proteins in C. elegans: a review and new findings.</title>
            <authorList>
                <person name="Ferrara T.M."/>
                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="16453163"/>
            <dbReference type="DOI" id="10.1007/s10974-005-9027-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="Dev. Dyn." volume="236" first="1093" last="1105">
            <title>Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.</title>
            <authorList>
                <person name="Ono K."/>
                <person name="Yu R."/>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="17326220"/>
            <dbReference type="DOI" id="10.1002/dvdy.21091"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="383" first="747" last="752">
            <title>The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Blangy A."/>
                <person name="Xiong G."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="18801371"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2008.08.083"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH RHO-1; CED-10; MIG-2 AND CDC-42</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="2424" last="2432">
            <title>A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="McGaha L.A."/>
                <person name="Mercer K.B."/>
                <person name="Stark T.J."/>
                <person name="Ferrara T.M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="18337465"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-01-0053"/>
        </citation>
        <scope>INTERACTION WITH SCPL-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2009" name="J. Mol. Biol." volume="386" first="976" last="988">
            <title>A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Xiong G."/>
                <person name="Qadota H."/>
                <person name="Mercer K.B."/>
                <person name="McGaha L.A."/>
                <person name="Oberhauser A.F."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="19244614"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2009.01.016"/>
        </citation>
        <scope>INTERACTION WITH LIM-9</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Genetics" volume="189" first="885" last="897">
            <title>Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.</title>
            <authorList>
                <person name="Raharjo W.H."/>
                <person name="Ghai V."/>
                <person name="Dineen A."/>
                <person name="Bastiani M."/>
                <person name="Gaudet J."/>
            </authorList>
            <dbReference type="PubMed" id="21868609"/>
            <dbReference type="DOI" id="10.1534/genetics.111.132449"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2012" name="Mol. Biol. Cell" volume="23" first="2623" last="2634">
            <title>UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wilson K.J."/>
                <person name="Qadota H."/>
                <person name="Mains P.E."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="22621901"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-01-0055"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MEL-26</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E40182" last="E40182">
            <title>Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Spooner P.M."/>
                <person name="Bonner J."/>
                <person name="Maricq A.V."/>
                <person name="Benian G.M."/>
                <person name="Norman K.R."/>
            </authorList>
            <dbReference type="PubMed" id="22768340"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0040182"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2013" name="Mol. Biol. Cell" volume="24" first="601" last="616">
            <title>CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Warner A."/>
                <person name="Xiong G."/>
                <person name="Qadota H."/>
                <person name="Rogalski T."/>
                <person name="Vogl A.W."/>
                <person name="Moerman D.G."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="23283987"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-06-0478"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CPNA-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2016" name="Mol. Biol. Cell" volume="27" first="1606" last="1620">
            <title>The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Mayans O."/>
                <person name="Matsunaga Y."/>
                <person name="McMurry J.L."/>
                <person name="Wilson K.J."/>
                <person name="Kwon G.E."/>
                <person name="Stanford R."/>
                <person name="Deehan K."/>
                <person name="Tinley T.L."/>
                <person name="Ngwa V.M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="27009202"/>
            <dbReference type="DOI" id="10.1091/mbc.E15-09-0675"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH UNC-15</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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            <id>O01761-3</id>
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            <fullName evidence="1">Inactive serine/threonine-protein kinase unc-89</fullName>
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            <fullName>Uncoordinated protein 89</fullName>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="1996" name="J. Cell Biol." volume="132" first="835" last="848">
            <title>The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="Tinley T.L."/>
                <person name="Tang X."/>
                <person name="Borodovsky M."/>
            </authorList>
            <dbReference type="PubMed" id="8603916"/>
            <dbReference type="DOI" id="10.1083/jcb.132.5.835"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Structure" volume="8" first="1079" last="1087">
            <title>Structure of a PH domain from the C. elegans muscle protein UNC-89 suggests a novel function.</title>
            <authorList>
                <person name="Blomberg N."/>
                <person name="Baraldi E."/>
                <person name="Sattler M."/>
                <person name="Saraste M."/>
                <person name="Nilges M."/>
            </authorList>
            <dbReference type="PubMed" id="11080629"/>
            <dbReference type="DOI" id="10.1016/S0969-2126(00)00509-8"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 341-458</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="J. Mol. Biol." volume="342" first="91" last="108">
            <title>Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains.</title>
            <authorList>
                <person name="Small T.M."/>
                <person name="Gernert K.M."/>
                <person name="Flaherty D.B."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="15313609"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2004.07.006"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 5922-7990 (ISOFORMS B/F)</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="J. Muscle Res. Cell Motil." volume="26" first="435" last="447">
            <title>Titin/connectin-related proteins in C. elegans: a review and new findings.</title>
            <authorList>
                <person name="Ferrara T.M."/>
                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="16453163"/>
            <dbReference type="DOI" id="10.1007/s10974-005-9027-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="Dev. Dyn." volume="236" first="1093" last="1105">
            <title>Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.</title>
            <authorList>
                <person name="Ono K."/>
                <person name="Yu R."/>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="17326220"/>
            <dbReference type="DOI" id="10.1002/dvdy.21091"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="383" first="747" last="752">
            <title>The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Blangy A."/>
                <person name="Xiong G."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="18801371"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2008.08.083"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH RHO-1; CED-10; MIG-2 AND CDC-42</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="2424" last="2432">
            <title>A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="McGaha L.A."/>
                <person name="Mercer K.B."/>
                <person name="Stark T.J."/>
                <person name="Ferrara T.M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="18337465"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-01-0053"/>
        </citation>
        <scope>INTERACTION WITH SCPL-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2009" name="J. Mol. Biol." volume="386" first="976" last="988">
            <title>A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Xiong G."/>
                <person name="Qadota H."/>
                <person name="Mercer K.B."/>
                <person name="McGaha L.A."/>
                <person name="Oberhauser A.F."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="19244614"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2009.01.016"/>
        </citation>
        <scope>INTERACTION WITH LIM-9</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Genetics" volume="189" first="885" last="897">
            <title>Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.</title>
            <authorList>
                <person name="Raharjo W.H."/>
                <person name="Ghai V."/>
                <person name="Dineen A."/>
                <person name="Bastiani M."/>
                <person name="Gaudet J."/>
            </authorList>
            <dbReference type="PubMed" id="21868609"/>
            <dbReference type="DOI" id="10.1534/genetics.111.132449"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2012" name="Mol. Biol. Cell" volume="23" first="2623" last="2634">
            <title>UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wilson K.J."/>
                <person name="Qadota H."/>
                <person name="Mains P.E."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="22621901"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-01-0055"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MEL-26</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E40182" last="E40182">
            <title>Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Spooner P.M."/>
                <person name="Bonner J."/>
                <person name="Maricq A.V."/>
                <person name="Benian G.M."/>
                <person name="Norman K.R."/>
            </authorList>
            <dbReference type="PubMed" id="22768340"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0040182"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2013" name="Mol. Biol. Cell" volume="24" first="601" last="616">
            <title>CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Warner A."/>
                <person name="Xiong G."/>
                <person name="Qadota H."/>
                <person name="Rogalski T."/>
                <person name="Vogl A.W."/>
                <person name="Moerman D.G."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="23283987"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-06-0478"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CPNA-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2016" name="Mol. Biol. Cell" volume="27" first="1606" last="1620">
            <title>The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Mayans O."/>
                <person name="Matsunaga Y."/>
                <person name="McMurry J.L."/>
                <person name="Wilson K.J."/>
                <person name="Kwon G.E."/>
                <person name="Stanford R."/>
                <person name="Deehan K."/>
                <person name="Tinley T.L."/>
                <person name="Ngwa V.M."/>
                <person name="Benian G.M."/>
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        <citation type="journal article" date="1996" name="J. Cell Biol." volume="132" first="835" last="848">
            <title>The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="Tinley T.L."/>
                <person name="Tang X."/>
                <person name="Borodovsky M."/>
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            <dbReference type="PubMed" id="8603916"/>
            <dbReference type="DOI" id="10.1083/jcb.132.5.835"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain>Bristol N2</strain>
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    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
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    <reference key="3">
        <citation type="journal article" date="2000" name="Structure" volume="8" first="1079" last="1087">
            <title>Structure of a PH domain from the C. elegans muscle protein UNC-89 suggests a novel function.</title>
            <authorList>
                <person name="Blomberg N."/>
                <person name="Baraldi E."/>
                <person name="Sattler M."/>
                <person name="Saraste M."/>
                <person name="Nilges M."/>
            </authorList>
            <dbReference type="PubMed" id="11080629"/>
            <dbReference type="DOI" id="10.1016/S0969-2126(00)00509-8"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 341-458</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="J. Mol. Biol." volume="342" first="91" last="108">
            <title>Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains.</title>
            <authorList>
                <person name="Small T.M."/>
                <person name="Gernert K.M."/>
                <person name="Flaherty D.B."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="15313609"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2004.07.006"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 5922-7990 (ISOFORMS B/F)</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="J. Muscle Res. Cell Motil." volume="26" first="435" last="447">
            <title>Titin/connectin-related proteins in C. elegans: a review and new findings.</title>
            <authorList>
                <person name="Ferrara T.M."/>
                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="16453163"/>
            <dbReference type="DOI" id="10.1007/s10974-005-9027-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="Dev. Dyn." volume="236" first="1093" last="1105">
            <title>Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.</title>
            <authorList>
                <person name="Ono K."/>
                <person name="Yu R."/>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="17326220"/>
            <dbReference type="DOI" id="10.1002/dvdy.21091"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference key="7">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="383" first="747" last="752">
            <title>The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Blangy A."/>
                <person name="Xiong G."/>
                <person name="Benian G.M."/>
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            <dbReference type="PubMed" id="18801371"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2008.08.083"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH RHO-1; CED-10; MIG-2 AND CDC-42</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference key="8">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="2424" last="2432">
            <title>A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="McGaha L.A."/>
                <person name="Mercer K.B."/>
                <person name="Stark T.J."/>
                <person name="Ferrara T.M."/>
                <person name="Benian G.M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1091/mbc.E08-01-0053"/>
        </citation>
        <scope>INTERACTION WITH SCPL-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
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    <reference key="9">
        <citation type="journal article" date="2009" name="J. Mol. Biol." volume="386" first="976" last="988">
            <title>A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Xiong G."/>
                <person name="Qadota H."/>
                <person name="Mercer K.B."/>
                <person name="McGaha L.A."/>
                <person name="Oberhauser A.F."/>
                <person name="Benian G.M."/>
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            <dbReference type="PubMed" id="19244614"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2009.01.016"/>
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        <scope>INTERACTION WITH LIM-9</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Genetics" volume="189" first="885" last="897">
            <title>Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.</title>
            <authorList>
                <person name="Raharjo W.H."/>
                <person name="Ghai V."/>
                <person name="Dineen A."/>
                <person name="Bastiani M."/>
                <person name="Gaudet J."/>
            </authorList>
            <dbReference type="PubMed" id="21868609"/>
            <dbReference type="DOI" id="10.1534/genetics.111.132449"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2012" name="Mol. Biol. Cell" volume="23" first="2623" last="2634">
            <title>UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wilson K.J."/>
                <person name="Qadota H."/>
                <person name="Mains P.E."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="22621901"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-01-0055"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MEL-26</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E40182" last="E40182">
            <title>Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Spooner P.M."/>
                <person name="Bonner J."/>
                <person name="Maricq A.V."/>
                <person name="Benian G.M."/>
                <person name="Norman K.R."/>
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            <dbReference type="PubMed" id="22768340"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0040182"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2013" name="Mol. Biol. Cell" volume="24" first="601" last="616">
            <title>CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Warner A."/>
                <person name="Xiong G."/>
                <person name="Qadota H."/>
                <person name="Rogalski T."/>
                <person name="Vogl A.W."/>
                <person name="Moerman D.G."/>
                <person name="Benian G.M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1091/mbc.E12-06-0478"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CPNA-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2016" name="Mol. Biol. Cell" volume="27" first="1606" last="1620">
            <title>The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Mayans O."/>
                <person name="Matsunaga Y."/>
                <person name="McMurry J.L."/>
                <person name="Wilson K.J."/>
                <person name="Kwon G.E."/>
                <person name="Stanford R."/>
                <person name="Deehan K."/>
                <person name="Tinley T.L."/>
                <person name="Ngwa V.M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="27009202"/>
            <dbReference type="DOI" id="10.1091/mbc.E15-09-0675"/>
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        <scope>INTERACTION WITH UNC-15</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
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        <citation type="journal article" date="1996" name="J. Cell Biol." volume="132" first="835" last="848">
            <title>The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="Tinley T.L."/>
                <person name="Tang X."/>
                <person name="Borodovsky M."/>
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            <dbReference type="DOI" id="10.1083/jcb.132.5.835"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Structure" volume="8" first="1079" last="1087">
            <title>Structure of a PH domain from the C. elegans muscle protein UNC-89 suggests a novel function.</title>
            <authorList>
                <person name="Blomberg N."/>
                <person name="Baraldi E."/>
                <person name="Sattler M."/>
                <person name="Saraste M."/>
                <person name="Nilges M."/>
            </authorList>
            <dbReference type="PubMed" id="11080629"/>
            <dbReference type="DOI" id="10.1016/S0969-2126(00)00509-8"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 341-458</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="J. Mol. Biol." volume="342" first="91" last="108">
            <title>Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains.</title>
            <authorList>
                <person name="Small T.M."/>
                <person name="Gernert K.M."/>
                <person name="Flaherty D.B."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="15313609"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2004.07.006"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 5922-7990 (ISOFORMS B/F)</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="J. Muscle Res. Cell Motil." volume="26" first="435" last="447">
            <title>Titin/connectin-related proteins in C. elegans: a review and new findings.</title>
            <authorList>
                <person name="Ferrara T.M."/>
                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="16453163"/>
            <dbReference type="DOI" id="10.1007/s10974-005-9027-4"/>
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        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="Dev. Dyn." volume="236" first="1093" last="1105">
            <title>Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.</title>
            <authorList>
                <person name="Ono K."/>
                <person name="Yu R."/>
                <person name="Ono S."/>
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            <dbReference type="DOI" id="10.1002/dvdy.21091"/>
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        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="383" first="747" last="752">
            <title>The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Blangy A."/>
                <person name="Xiong G."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="18801371"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2008.08.083"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH RHO-1; CED-10; MIG-2 AND CDC-42</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="2424" last="2432">
            <title>A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="McGaha L.A."/>
                <person name="Mercer K.B."/>
                <person name="Stark T.J."/>
                <person name="Ferrara T.M."/>
                <person name="Benian G.M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1091/mbc.E08-01-0053"/>
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        <scope>INTERACTION WITH SCPL-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
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    <reference key="9">
        <citation type="journal article" date="2009" name="J. Mol. Biol." volume="386" first="976" last="988">
            <title>A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Xiong G."/>
                <person name="Qadota H."/>
                <person name="Mercer K.B."/>
                <person name="McGaha L.A."/>
                <person name="Oberhauser A.F."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="19244614"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2009.01.016"/>
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        <scope>INTERACTION WITH LIM-9</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Genetics" volume="189" first="885" last="897">
            <title>Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.</title>
            <authorList>
                <person name="Raharjo W.H."/>
                <person name="Ghai V."/>
                <person name="Dineen A."/>
                <person name="Bastiani M."/>
                <person name="Gaudet J."/>
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            <dbReference type="PubMed" id="21868609"/>
            <dbReference type="DOI" id="10.1534/genetics.111.132449"/>
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        <scope>FUNCTION</scope>
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    <reference key="11">
        <citation type="journal article" date="2012" name="Mol. Biol. Cell" volume="23" first="2623" last="2634">
            <title>UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wilson K.J."/>
                <person name="Qadota H."/>
                <person name="Mains P.E."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="22621901"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-01-0055"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MEL-26</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E40182" last="E40182">
            <title>Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Spooner P.M."/>
                <person name="Bonner J."/>
                <person name="Maricq A.V."/>
                <person name="Benian G.M."/>
                <person name="Norman K.R."/>
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            <dbReference type="PubMed" id="22768340"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0040182"/>
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        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2013" name="Mol. Biol. Cell" volume="24" first="601" last="616">
            <title>CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Warner A."/>
                <person name="Xiong G."/>
                <person name="Qadota H."/>
                <person name="Rogalski T."/>
                <person name="Vogl A.W."/>
                <person name="Moerman D.G."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="23283987"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-06-0478"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CPNA-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2016" name="Mol. Biol. Cell" volume="27" first="1606" last="1620">
            <title>The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Mayans O."/>
                <person name="Matsunaga Y."/>
                <person name="McMurry J.L."/>
                <person name="Wilson K.J."/>
                <person name="Kwon G.E."/>
                <person name="Stanford R."/>
                <person name="Deehan K."/>
                <person name="Tinley T.L."/>
                <person name="Ngwa V.M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="27009202"/>
            <dbReference type="DOI" id="10.1091/mbc.E15-09-0675"/>
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        <scope>INTERACTION WITH UNC-15</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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        <citation type="journal article" date="1996" name="J. Cell Biol." volume="132" first="835" last="848">
            <title>The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="Tinley T.L."/>
                <person name="Tang X."/>
                <person name="Borodovsky M."/>
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            <dbReference type="DOI" id="10.1083/jcb.132.5.835"/>
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        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
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    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain>Bristol N2</strain>
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    <reference key="3">
        <citation type="journal article" date="2000" name="Structure" volume="8" first="1079" last="1087">
            <title>Structure of a PH domain from the C. elegans muscle protein UNC-89 suggests a novel function.</title>
            <authorList>
                <person name="Blomberg N."/>
                <person name="Baraldi E."/>
                <person name="Sattler M."/>
                <person name="Saraste M."/>
                <person name="Nilges M."/>
            </authorList>
            <dbReference type="PubMed" id="11080629"/>
            <dbReference type="DOI" id="10.1016/S0969-2126(00)00509-8"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 341-458</scope>
        <scope>DOMAIN</scope>
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    <reference key="4">
        <citation type="journal article" date="2004" name="J. Mol. Biol." volume="342" first="91" last="108">
            <title>Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains.</title>
            <authorList>
                <person name="Small T.M."/>
                <person name="Gernert K.M."/>
                <person name="Flaherty D.B."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="15313609"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2004.07.006"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 5922-7990 (ISOFORMS B/F)</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="J. Muscle Res. Cell Motil." volume="26" first="435" last="447">
            <title>Titin/connectin-related proteins in C. elegans: a review and new findings.</title>
            <authorList>
                <person name="Ferrara T.M."/>
                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="16453163"/>
            <dbReference type="DOI" id="10.1007/s10974-005-9027-4"/>
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        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference key="6">
        <citation type="journal article" date="2007" name="Dev. Dyn." volume="236" first="1093" last="1105">
            <title>Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.</title>
            <authorList>
                <person name="Ono K."/>
                <person name="Yu R."/>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="17326220"/>
            <dbReference type="DOI" id="10.1002/dvdy.21091"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference key="7">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="383" first="747" last="752">
            <title>The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Blangy A."/>
                <person name="Xiong G."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="18801371"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2008.08.083"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH RHO-1; CED-10; MIG-2 AND CDC-42</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference key="8">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="2424" last="2432">
            <title>A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="McGaha L.A."/>
                <person name="Mercer K.B."/>
                <person name="Stark T.J."/>
                <person name="Ferrara T.M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="18337465"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-01-0053"/>
        </citation>
        <scope>INTERACTION WITH SCPL-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
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    <reference key="9">
        <citation type="journal article" date="2009" name="J. Mol. Biol." volume="386" first="976" last="988">
            <title>A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Xiong G."/>
                <person name="Qadota H."/>
                <person name="Mercer K.B."/>
                <person name="McGaha L.A."/>
                <person name="Oberhauser A.F."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="19244614"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2009.01.016"/>
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        <scope>INTERACTION WITH LIM-9</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
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    <reference key="10">
        <citation type="journal article" date="2011" name="Genetics" volume="189" first="885" last="897">
            <title>Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.</title>
            <authorList>
                <person name="Raharjo W.H."/>
                <person name="Ghai V."/>
                <person name="Dineen A."/>
                <person name="Bastiani M."/>
                <person name="Gaudet J."/>
            </authorList>
            <dbReference type="PubMed" id="21868609"/>
            <dbReference type="DOI" id="10.1534/genetics.111.132449"/>
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        <scope>FUNCTION</scope>
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    <reference key="11">
        <citation type="journal article" date="2012" name="Mol. Biol. Cell" volume="23" first="2623" last="2634">
            <title>UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wilson K.J."/>
                <person name="Qadota H."/>
                <person name="Mains P.E."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="22621901"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-01-0055"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MEL-26</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E40182" last="E40182">
            <title>Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Spooner P.M."/>
                <person name="Bonner J."/>
                <person name="Maricq A.V."/>
                <person name="Benian G.M."/>
                <person name="Norman K.R."/>
            </authorList>
            <dbReference type="PubMed" id="22768340"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0040182"/>
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        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2013" name="Mol. Biol. Cell" volume="24" first="601" last="616">
            <title>CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Warner A."/>
                <person name="Xiong G."/>
                <person name="Qadota H."/>
                <person name="Rogalski T."/>
                <person name="Vogl A.W."/>
                <person name="Moerman D.G."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="23283987"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-06-0478"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CPNA-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
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    <reference key="14">
        <citation type="journal article" date="2016" name="Mol. Biol. Cell" volume="27" first="1606" last="1620">
            <title>The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Mayans O."/>
                <person name="Matsunaga Y."/>
                <person name="McMurry J.L."/>
                <person name="Wilson K.J."/>
                <person name="Kwon G.E."/>
                <person name="Stanford R."/>
                <person name="Deehan K."/>
                <person name="Tinley T.L."/>
                <person name="Ngwa V.M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="27009202"/>
            <dbReference type="DOI" id="10.1091/mbc.E15-09-0675"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH UNC-15</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
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    <dbReference type="RefSeq" id="NP_001020989.1">
        <property type="nucleotide sequence ID" value="NM_001025818.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C09D1.1f">
        <property type="protein sequence ID" value="CE37703"/>
        <property type="gene ID" value="WBGene00006820"/>
        <property type="gene designation" value="unc-89"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="7441" mass="824244" checksum="4B102760FC1131D7" modified="2005-09-13" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-28" modified="2026-01-28" version="206" xmlns="https://uniprot.org/uniprot">
    <accession>O01761-7</accession>
    <name>UNC89_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform g of Muscle M-line assembly protein unc-89</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Inactive serine/threonine-protein kinase unc-89</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Obscurin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Uncoordinated protein 89</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">unc-89</name>
        <name type="ORF">C09D1.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="1996" name="J. Cell Biol." volume="132" first="835" last="848">
            <title>The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="Tinley T.L."/>
                <person name="Tang X."/>
                <person name="Borodovsky M."/>
            </authorList>
            <dbReference type="PubMed" id="8603916"/>
            <dbReference type="DOI" id="10.1083/jcb.132.5.835"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Structure" volume="8" first="1079" last="1087">
            <title>Structure of a PH domain from the C. elegans muscle protein UNC-89 suggests a novel function.</title>
            <authorList>
                <person name="Blomberg N."/>
                <person name="Baraldi E."/>
                <person name="Sattler M."/>
                <person name="Saraste M."/>
                <person name="Nilges M."/>
            </authorList>
            <dbReference type="PubMed" id="11080629"/>
            <dbReference type="DOI" id="10.1016/S0969-2126(00)00509-8"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 341-458</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="J. Mol. Biol." volume="342" first="91" last="108">
            <title>Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains.</title>
            <authorList>
                <person name="Small T.M."/>
                <person name="Gernert K.M."/>
                <person name="Flaherty D.B."/>
                <person name="Mercer K.B."/>
                <person name="Borodovsky M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="15313609"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2004.07.006"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 5922-7990 (ISOFORMS B/F)</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="J. Muscle Res. Cell Motil." volume="26" first="435" last="447">
            <title>Titin/connectin-related proteins in C. elegans: a review and new findings.</title>
            <authorList>
                <person name="Ferrara T.M."/>
                <person name="Flaherty D.B."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="16453163"/>
            <dbReference type="DOI" id="10.1007/s10974-005-9027-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="Dev. Dyn." volume="236" first="1093" last="1105">
            <title>Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.</title>
            <authorList>
                <person name="Ono K."/>
                <person name="Yu R."/>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="17326220"/>
            <dbReference type="DOI" id="10.1002/dvdy.21091"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="383" first="747" last="752">
            <title>The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Blangy A."/>
                <person name="Xiong G."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="18801371"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2008.08.083"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH RHO-1; CED-10; MIG-2 AND CDC-42</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="2424" last="2432">
            <title>A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="McGaha L.A."/>
                <person name="Mercer K.B."/>
                <person name="Stark T.J."/>
                <person name="Ferrara T.M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="18337465"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-01-0053"/>
        </citation>
        <scope>INTERACTION WITH SCPL-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2009" name="J. Mol. Biol." volume="386" first="976" last="988">
            <title>A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Xiong G."/>
                <person name="Qadota H."/>
                <person name="Mercer K.B."/>
                <person name="McGaha L.A."/>
                <person name="Oberhauser A.F."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="19244614"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2009.01.016"/>
        </citation>
        <scope>INTERACTION WITH LIM-9</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Genetics" volume="189" first="885" last="897">
            <title>Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.</title>
            <authorList>
                <person name="Raharjo W.H."/>
                <person name="Ghai V."/>
                <person name="Dineen A."/>
                <person name="Bastiani M."/>
                <person name="Gaudet J."/>
            </authorList>
            <dbReference type="PubMed" id="21868609"/>
            <dbReference type="DOI" id="10.1534/genetics.111.132449"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2012" name="Mol. Biol. Cell" volume="23" first="2623" last="2634">
            <title>UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wilson K.J."/>
                <person name="Qadota H."/>
                <person name="Mains P.E."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="22621901"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-01-0055"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MEL-26</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E40182" last="E40182">
            <title>Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Spooner P.M."/>
                <person name="Bonner J."/>
                <person name="Maricq A.V."/>
                <person name="Benian G.M."/>
                <person name="Norman K.R."/>
            </authorList>
            <dbReference type="PubMed" id="22768340"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0040182"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2013" name="Mol. Biol. Cell" volume="24" first="601" last="616">
            <title>CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Warner A."/>
                <person name="Xiong G."/>
                <person name="Qadota H."/>
                <person name="Rogalski T."/>
                <person name="Vogl A.W."/>
                <person name="Moerman D.G."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="23283987"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-06-0478"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CPNA-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2016" name="Mol. Biol. Cell" volume="27" first="1606" last="1620">
            <title>The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Mayans O."/>
                <person name="Matsunaga Y."/>
                <person name="McMurry J.L."/>
                <person name="Wilson K.J."/>
                <person name="Kwon G.E."/>
                <person name="Stanford R."/>
                <person name="Deehan K."/>
                <person name="Tinley T.L."/>
                <person name="Ngwa V.M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="27009202"/>
            <dbReference type="DOI" id="10.1091/mbc.E15-09-0675"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH UNC-15</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O01761-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_015545"/>
        </isoform>
        <isoform>
            <id>O01761-6</id>
            <name>f</name>
            <sequence type="described" ref="VSP_015543"/>
        </isoform>
        <isoform>
            <id>O01761-3</id>
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            <sequence type="described" ref="VSP_015547 VSP_015541"/>
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        <isoform>
            <id>O01761-7</id>
            <name>g</name>
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        </isoform>
        <isoform>
            <id>O01761-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O01761-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_015545 VSP_015543"/>
        </isoform>
        <isoform>
            <id>O01761-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_015546 VSP_015542"/>
        </isoform>
    </comment>
    <dbReference type="WormBase" id="C09D1.1g">
        <property type="protein sequence ID" value="CE52389"/>
        <property type="gene ID" value="WBGene00006820"/>
        <property type="gene designation" value="unc-89"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="7122" mass="786772" checksum="E0AADE021082BD5B" modified="2005-09-13" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>O17261</accession>
    <name>O17261_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T23F4.2</name>
        <name evidence="2 4" type="ORF">T23F4.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD73620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PIR" id="T32398">
        <property type="entry name" value="T32398"/>
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    <dbReference type="RefSeq" id="NP_493923.2">
        <property type="nucleotide sequence ID" value="NM_061522.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O17261"/>
    <dbReference type="SMR" id="O17261"/>
    <dbReference type="PaxDb" id="6239-T23F4.2"/>
    <dbReference type="PeptideAtlas" id="O17261"/>
    <dbReference type="GeneID" id="173501"/>
    <dbReference type="UCSC" id="T23F4.2">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00020740"/>
    <dbReference type="CTD" id="173501"/>
    <dbReference type="WormBase" id="T23F4.2a">
        <property type="protein sequence ID" value="CE32070"/>
        <property type="gene ID" value="WBGene00020740"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SWNR">
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    <dbReference type="HOGENOM" id="CLU_1300688_0_0_1"/>
    <dbReference type="OMA" id="EPNKLWE"/>
    <dbReference type="OrthoDB" id="5805034at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020740">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O17261">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38608">
        <property type="entry name" value="PROTEIN CBG07207"/>
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    <dbReference type="PANTHER" id="PTHR38608:SF4">
        <property type="entry name" value="PROTEIN CBG07207"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="27"/>
            <end position="82"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="36"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="153"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="167"/>
            <end position="177"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="CCD73620.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        <source>
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        <recommendedName>
            <fullName evidence="3">Isoform b of Zinc phosphodiesterase ELAC protein 2 homolog</fullName>
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        <alternativeName>
            <fullName evidence="1">tRNA 3 endonuclease 2</fullName>
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        <alternativeName>
            <fullName evidence="1">tRNase Z 2</fullName>
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    <gene>
        <name evidence="5" type="primary">elac-2</name>
        <name evidence="5" type="ORF">E04A4.4</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Dev. Biol." volume="266" first="151" last="160">
            <title>The Caenorhabditis elegans homolog of the putative prostate cancer susceptibility gene ELAC2, hoe-1, plays a role in germline proliferation.</title>
            <authorList>
                <person name="Smith M.M."/>
                <person name="Levitan D.J."/>
            </authorList>
            <dbReference type="PubMed" id="14729485"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2003.10.016"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2022" name="Elife" volume="11" first="0" last="0">
            <title>A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response.</title>
            <authorList>
                <person name="Held J.P."/>
                <person name="Feng G."/>
                <person name="Saunders B.R."/>
                <person name="Pereira C.V."/>
                <person name="Burkewitz K."/>
                <person name="Patel M.R."/>
            </authorList>
            <dbReference type="PubMed" id="35451962"/>
            <dbReference type="DOI" id="10.7554/elife.71634"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF MET-1; 636-LYS--ARG-639; ASP-697 AND 804-VAL--ILE-812</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a role in mitochondrial unfolded protein response (PubMed:35451962). Upon mitochondrial stress is exported from the nucleus where its tRNA endonuclease activity is negatively regulated (PubMed:35451962). In response to mitochondrial stress, might be involved in activating a transcriptional response in an ATFS-1- and DVE-1-dependent manner (PubMed:35451962). May play a role in negatively regulating the mitochondrial membrane potential (PubMed:35451962).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <text evidence="2">Accumulates in the nucleus upon mitochondrial stress.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O44476-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_009390"/>
        </isoform>
        <isoform>
            <id>O44476-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="RefSeq" id="NP_001023110.1">
        <property type="nucleotide sequence ID" value="NM_001027939.2"/>
    </dbReference>
    <dbReference type="WormBase" id="E04A4.4b">
        <property type="protein sequence ID" value="CE36588"/>
        <property type="gene ID" value="WBGene00001983"/>
        <property type="gene designation" value="elac-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9BQ52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="35451962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="35451962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="E04A4.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="E04A4.4b"/>
        </source>
    </evidence>
    <sequence length="760" mass="85514" checksum="E0BB04F6A6DF58D7" modified="2001-12-01" version="2" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>O44780</accession>
    <name>O44780_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GlycosylPhosphatidylinositol Anchor Attachment 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">gpaa-1</name>
        <name evidence="5" type="synonym">hpo-3</name>
        <name evidence="3" type="ORF">CELE_F33D11.9</name>
        <name evidence="5" type="ORF">F33D11.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD66442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T32772">
        <property type="entry name" value="T32772"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379761.1">
        <property type="nucleotide sequence ID" value="NM_001392367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O44780"/>
    <dbReference type="SMR" id="O44780"/>
    <dbReference type="PeptideAtlas" id="O44780"/>
    <dbReference type="GeneID" id="172256"/>
    <dbReference type="UCSC" id="F33D11.9a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018006"/>
    <dbReference type="CTD" id="172256"/>
    <dbReference type="WormBase" id="F33D11.9a">
        <property type="protein sequence ID" value="CE37904"/>
        <property type="gene ID" value="WBGene00018006"/>
        <property type="gene designation" value="gpaa-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_987771_0_0_1"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018006">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O44780">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD66442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F33D11.9a"/>
        </source>
    </evidence>
    <sequence length="282" mass="31831" checksum="0DEBB33F8F3AB0C5" modified="2005-02-01" version="3">MYIIPLTILVSPLVISAYFEWTKIQEFQFPVVHLAFHVLGFFYYIATTYVFQTIGTTFVLQWMQWPFVGIDGCDGQFTPSWSLINSFLIFFMIPLGPYVFLKEPVRCVPSMRIVCLLETSLVLYGICLTNFGLAILCTAFVVPIVFLMTYESSDRTRSIFRSSVLAILNPISVLAFVAINIPGMFGQLFPTISQDSWLAAAQSIALTAIREDVEFKVNHFFLLCCFGYPIWNMLFACSMRYGPEPQGSLGIFGNGSDDDDGDDDDGPQKTNRGHSTKKNKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>O44791</accession>
    <name>O44791_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">dmsr-4</name>
        <name evidence="7" type="ORF">CELE_D1069.4</name>
        <name evidence="9" type="ORF">D1069.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD67131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T32778">
        <property type="entry name" value="T32778"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379796.1">
        <property type="nucleotide sequence ID" value="NM_001392993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O44791"/>
    <dbReference type="SMR" id="O44791"/>
    <dbReference type="PaxDb" id="6239-D1069.4"/>
    <dbReference type="GeneID" id="183924"/>
    <dbReference type="UCSC" id="D1069.4">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017038"/>
    <dbReference type="CTD" id="183924"/>
    <dbReference type="WormBase" id="D1069.4a">
        <property type="protein sequence ID" value="CE17616"/>
        <property type="gene ID" value="WBGene00017038"/>
        <property type="gene designation" value="dmsr-4"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RFAV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_24_4_1"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="PhylomeDB" id="O44791"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017038">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O44791">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="49"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD67131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="D1069.4a"/>
        </source>
    </evidence>
    <sequence length="379" mass="43881" checksum="F514A73C6E396E04" modified="1998-06-01" version="1">MCQDEGGTLFDPQDPAVSGLIDALEQFQSFYTYFHRYACLFICIVGVFSNAIHIAVLSRPRMRRCAVNSVLTAVAFCDVITMTSYSIYLMRFRFYETDHGYSYIWLVFLKFHVWSSMTLHAITLYMGGALAFIRWQALGNIHSKWLQPRNSWQLFGVVSVVLSIVCLPTLVLHKIYEIESPEIETSTVSEVLRLSGQSIPKEVRYSLNFSTYSCAFFKFNLWMLAIVLKAIPCALLLWFTIALVVKLRQTDEKRNYLYSKSFRKHVKKTTVPDRTTYMLIIMLVVFLVTELPQGFLALLNGLYTGDVNIYIYKNLSELLDFLSLINCSVDFLLYCVMSSRYRQTFGHMLIRVESWLRNHGERRRLAREIKKKLPAPVGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-07-24" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>O45879-2</accession>
    <name>MNR1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform 2 of Menorin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mnr-1</name>
        <name evidence="4" type="ORF">W01F3.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="Cell" volume="155" first="296" last="307">
            <title>An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis.</title>
            <authorList>
                <person name="Dong X."/>
                <person name="Liu O.W."/>
                <person name="Howell A.S."/>
                <person name="Shen K."/>
            </authorList>
            <dbReference type="PubMed" id="24120131"/>
            <dbReference type="DOI" id="10.1016/j.cell.2013.08.059"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SAX-7 AND DMA-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 107-TRP--LEU-530</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2013" name="Cell" volume="155" first="308" last="320">
            <title>Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Salzberg Y."/>
                <person name="Diaz-Balzac C.A."/>
                <person name="Ramirez-Suarez N.J."/>
                <person name="Attreed M."/>
                <person name="Tecle E."/>
                <person name="Desbois M."/>
                <person name="Kaprielian Z."/>
                <person name="Buelow H.E."/>
            </authorList>
            <dbReference type="PubMed" id="24120132"/>
            <dbReference type="DOI" id="10.1016/j.cell.2013.08.058"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SAX-7</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLY-42; VAL-131; 209-ARG--LEU-530; GLY-370 AND 462-GLN--LEU-530</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2016" name="Elife" volume="5" first="0" last="0">
            <title>A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans.</title>
            <authorList>
                <person name="Zou W."/>
                <person name="Shen A."/>
                <person name="Dong X."/>
                <person name="Tugizova M."/>
                <person name="Xiang Y.K."/>
                <person name="Shen K."/>
            </authorList>
            <dbReference type="PubMed" id="27705746"/>
            <dbReference type="DOI" id="10.7554/elife.18345"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O45879-2</id>
            <name>2</name>
            <sequence type="described" ref="VSP_062343"/>
        </isoform>
        <isoform>
            <id>O45879-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_507991.1">
        <property type="nucleotide sequence ID" value="NM_075590.6"/>
    </dbReference>
    <dbReference type="WormBase" id="W01F3.1b">
        <property type="protein sequence ID" value="CE26982"/>
        <property type="gene ID" value="WBGene00012184"/>
        <property type="gene designation" value="mnr-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="24120132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="W01F3.1a"/>
        </source>
    </evidence>
    <sequence length="476" mass="54322" checksum="624972D8A5BF6051" modified="2001-06-01" version="2" precursor="true">MMISILLVFAVSTAYCRDYGREMRATRMSVVDFWKNETKGDGLNVRVAHGVNSWPDLVDQLHAIKINFRSNEVVRPVLQDLYASQADPTSPVLQYPVILHANVFRSPRSVETEVDPSTFVEKAKDLFPDATLSLGWTKQSNFSHLHPKFKKLSWRQLFHILEYISRLDQPVMLSVRLSVAAHSKEQLLWLLGMDQSISLLLWSDAEDHVTNWTPIVELRRSTTKNRILYDLDPKHRKFLQTDSNEPIATPPTFSLQDWQAVEFSSSGSQLSTVVRSEKGPAFLGEPTALLLSKIPPPNFPSEQKISGKVHFLPKKGMENVDLDENSGVSIYLMDKVQDIDSPKIKNSLEVFIGFDGKIKITNGQLKNLPYYETKSVGQLPDSDCYGFEVTDMGWRVKLDAWTAECGNQKLRKRRTVSIELDTPFQKNRHLRNVVVSKKGDSAVDFLLEELQHKNAYNYRNPWITVVSTILLMIYLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>P34445-2</accession>
    <name>YL87_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Uncharacterized protein F54C8.7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">F54C8.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34445-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_016114"/>
        </isoform>
        <isoform>
            <id>P34445-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022604.1">
        <property type="nucleotide sequence ID" value="NM_001027433.7"/>
    </dbReference>
    <dbReference type="WormBase" id="F54C8.7a">
        <property type="protein sequence ID" value="CE28833"/>
        <property type="gene ID" value="WBGene00010040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="288" mass="32554" checksum="4C0827EA7DF4FAD4" modified="2005-11-08" version="3">MGLLSKKNSIKLYRQNRQPLTTPVSKRPLEKCPRIDTAQVAAKVESFKKWTIGTFKNSKQQLLEHMGKIDKTVDPEFEAQCEVLKDIHRRYGLVVAAAKNFSHVLTQMAEAEKKLSESFYQLSMKEEQIKAQCTMTSETMRGVGEQAASLDACLRYFISSMETVYNQTITDTLHTIYNTESARIEYDVDRNDISAATNPPQGQLTKNLPVGATEKCEEKKAKYEKLKNDAKIKMRLLEENRISVVAAQLEKLQSALAAYYSGNAKLLEASVRELSFLQSPQPSFIPTM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>P34552-2</accession>
    <name>ALXA_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Apoptosis-linked gene 2-interacting protein X 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Prion-like-(Q/N-rich) domain-bearing protein 58</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Protein YNK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">alx-1</name>
        <name type="synonym">pqn-58</name>
        <name type="ORF">R10E12.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Biochim. Biophys. Acta" volume="1354" first="231" last="240">
            <title>Molecular cloning of a splice variant of Caenorhabditis elegans YNK1, a putative element in signal transduction.</title>
            <authorList>
                <person name="Che S."/>
                <person name="Weil M.M."/>
                <person name="Etkin L.D."/>
                <person name="Epstein H.F."/>
                <person name="Kuang J."/>
            </authorList>
            <dbReference type="PubMed" id="9427532"/>
            <dbReference type="DOI" id="10.1016/S0167-4781(97)00112-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Development" volume="132" first="5081" last="5092">
            <title>LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shaye D.D."/>
                <person name="Greenwald I."/>
            </authorList>
            <dbReference type="PubMed" id="16236769"/>
            <dbReference type="DOI" id="10.1242/dev.02076"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34552-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_016612"/>
        </isoform>
        <isoform>
            <id>P34552-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34552-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_016611"/>
        </isoform>
        <isoform>
            <id>P34552-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_016613"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_499213.1">
        <property type="nucleotide sequence ID" value="NM_066812.8"/>
    </dbReference>
    <dbReference type="WormBase" id="R10E12.1a">
        <property type="protein sequence ID" value="CE25075"/>
        <property type="gene ID" value="WBGene00007010"/>
        <property type="gene designation" value="alx-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="861" mass="96246" checksum="F2F600623FF74965" modified="2005-12-20" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>P34552-3</accession>
    <name>ALXA_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Apoptosis-linked gene 2-interacting protein X 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Prion-like-(Q/N-rich) domain-bearing protein 58</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Protein YNK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">alx-1</name>
        <name type="synonym">pqn-58</name>
        <name type="ORF">R10E12.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Biochim. Biophys. Acta" volume="1354" first="231" last="240">
            <title>Molecular cloning of a splice variant of Caenorhabditis elegans YNK1, a putative element in signal transduction.</title>
            <authorList>
                <person name="Che S."/>
                <person name="Weil M.M."/>
                <person name="Etkin L.D."/>
                <person name="Epstein H.F."/>
                <person name="Kuang J."/>
            </authorList>
            <dbReference type="PubMed" id="9427532"/>
            <dbReference type="DOI" id="10.1016/S0167-4781(97)00112-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Development" volume="132" first="5081" last="5092">
            <title>LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shaye D.D."/>
                <person name="Greenwald I."/>
            </authorList>
            <dbReference type="PubMed" id="16236769"/>
            <dbReference type="DOI" id="10.1242/dev.02076"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34552-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_016611"/>
        </isoform>
        <isoform>
            <id>P34552-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_016612"/>
        </isoform>
        <isoform>
            <id>P34552-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34552-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_016613"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022714.1">
        <property type="nucleotide sequence ID" value="NM_001027543.4"/>
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    <dbReference type="WormBase" id="R10E12.1c">
        <property type="protein sequence ID" value="CE31853"/>
        <property type="gene ID" value="WBGene00007010"/>
        <property type="gene designation" value="alx-1"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="846" mass="93987" checksum="B8124DFFD49D1A46" modified="2005-12-20" version="3"> </sequence>
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<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>P34709-2</accession>
    <name>TRA2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Sex-determining transformer protein 2</fullName>
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        <alternativeName>
            <fullName>Ce-Tra-2</fullName>
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    <gene>
        <name type="primary">tra-2</name>
        <name type="ORF">C15F1.3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="EMBO J." volume="10" first="171" last="176">
            <title>Molecular analysis of tra-2, a sex determining gene in C.elegans.</title>
            <authorList>
                <person name="Okkema P.G."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="1703488"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="Mol. Biol. Cell" volume="3" first="461" last="473">
            <title>tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway.</title>
            <authorList>
                <person name="Kuwabara P.E."/>
                <person name="Okkema P.G."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="1498366"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRA-2A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Dev. Biol." volume="204" first="251" last="262">
            <title>Germ-line regulation of the Caenorhabditis elegans sex-determining gene tra-2.</title>
            <authorList>
                <person name="Kuwabara P.E."/>
                <person name="Okkema P.G."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="9851857"/>
            <dbReference type="DOI" id="10.1006/dbio.1998.9062"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRA-2A)</scope>
        <scope>ALTERNATIVE INITIATION (ISOFORM TRA-2B)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="Genes Dev." volume="13" first="1453" last="1463">
            <title>Negative regulation of male development in Caenorhabditis elegans by a protein-protein interaction between TRA-2A and FEM-3.</title>
            <authorList>
                <person name="Mehra A."/>
                <person name="Gaudet J."/>
                <person name="Heck L."/>
                <person name="Kuwabara P.E."/>
                <person name="Spence A.M."/>
            </authorList>
            <dbReference type="PubMed" id="10364161"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH FEM-3</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2000" name="Genes Dev." volume="14" first="901" last="906">
            <title>Proteolysis in Caenorhabditis elegans sex determination: cleavage of TRA-2A by TRA-3.</title>
            <authorList>
                <person name="Sokol S.B."/>
                <person name="Kuwabara P.E."/>
            </authorList>
            <dbReference type="PubMed" id="10783162"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CLEAVAGE BY TRA-3</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2000" name="Genes Dev." volume="14" first="3153" last="3165">
            <title>Direct protein-protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans.</title>
            <authorList>
                <person name="Lum D.H."/>
                <person name="Kuwabara P.E."/>
                <person name="Zarkower D."/>
                <person name="Spence A.M."/>
            </authorList>
            <dbReference type="PubMed" id="11124807"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH TRA-1</scope>
        <scope>MUTAGENESIS OF CYS-1392; GLU-1393 AND ARG-1400</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2001" name="EMBO J." volume="20" first="1363" last="1372">
            <title>The TRA-1 transcription factor binds TRA-2 to regulate sexual fates in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wang S."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="11250902"/>
            <dbReference type="DOI" id="10.1093/emboj/20.6.1363"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH TRA-1</scope>
        <scope>MUTAGENESIS OF GLU-1393; ARG-1400 AND PRO-1411</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2002" name="Curr. Biol." volume="12" first="2035" last="2041">
            <title>Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2.</title>
            <authorList>
                <person name="Haag E.S."/>
                <person name="Wang S."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="12477393"/>
            <dbReference type="DOI" id="10.1016/S0960-9822(02)01333-7"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH FEM-3</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2002" name="Genetics" volume="161" first="99" last="107">
            <title>Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis.</title>
            <authorList>
                <person name="Graustein A."/>
                <person name="Gaspar J.M."/>
                <person name="Walters J.R."/>
                <person name="Palopoli M.F."/>
            </authorList>
            <dbReference type="PubMed" id="12019226"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-142</scope>
        <source>
            <strain>AB1</strain>
            <strain>AB2</strain>
            <strain>CB4507</strain>
            <strain>CB4851</strain>
            <strain>CB4852</strain>
            <strain>CB4853</strain>
            <strain>CB4854</strain>
            <strain>CB4855</strain>
            <strain>CB4856</strain>
            <strain>CB4857</strain>
            <strain>CB4858</strain>
            <strain>CB4932</strain>
            <strain>DH424</strain>
            <strain>DR1344</strain>
            <strain>PB303</strain>
            <strain>PB305</strain>
            <strain>PB306</strain>
            <strain>PB307</strain>
            <strain>TR388</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <event type="alternative initiation"/>
        <isoform>
            <id>P34709-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_011746 VSP_011747"/>
        </isoform>
        <isoform>
            <id>P34709-1</id>
            <name>Tra-2A</name>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34709-3</id>
            <name>Tra-2B</name>
            <sequence type="described" ref="VSP_018823"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021954.1">
        <property type="nucleotide sequence ID" value="NM_001026783.6"/>
    </dbReference>
    <dbReference type="WormBase" id="C15F1.3b">
        <property type="protein sequence ID" value="CE23547"/>
        <property type="gene ID" value="WBGene00006605"/>
        <property type="gene designation" value="tra-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="1147" mass="133168" checksum="5B083B97EB9AA13D" modified="1994-02-01" version="1" precursor="true"> </sequence>
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<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>P34709-3</accession>
    <name>TRA2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform Tra-2B of Sex-determining transformer protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Ce-Tra-2</fullName>
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    </protein>
    <gene>
        <name type="primary">tra-2</name>
        <name type="ORF">C15F1.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="EMBO J." volume="10" first="171" last="176">
            <title>Molecular analysis of tra-2, a sex determining gene in C.elegans.</title>
            <authorList>
                <person name="Okkema P.G."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="1703488"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="Mol. Biol. Cell" volume="3" first="461" last="473">
            <title>tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway.</title>
            <authorList>
                <person name="Kuwabara P.E."/>
                <person name="Okkema P.G."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="1498366"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRA-2A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Dev. Biol." volume="204" first="251" last="262">
            <title>Germ-line regulation of the Caenorhabditis elegans sex-determining gene tra-2.</title>
            <authorList>
                <person name="Kuwabara P.E."/>
                <person name="Okkema P.G."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="9851857"/>
            <dbReference type="DOI" id="10.1006/dbio.1998.9062"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRA-2A)</scope>
        <scope>ALTERNATIVE INITIATION (ISOFORM TRA-2B)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="Genes Dev." volume="13" first="1453" last="1463">
            <title>Negative regulation of male development in Caenorhabditis elegans by a protein-protein interaction between TRA-2A and FEM-3.</title>
            <authorList>
                <person name="Mehra A."/>
                <person name="Gaudet J."/>
                <person name="Heck L."/>
                <person name="Kuwabara P.E."/>
                <person name="Spence A.M."/>
            </authorList>
            <dbReference type="PubMed" id="10364161"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH FEM-3</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2000" name="Genes Dev." volume="14" first="901" last="906">
            <title>Proteolysis in Caenorhabditis elegans sex determination: cleavage of TRA-2A by TRA-3.</title>
            <authorList>
                <person name="Sokol S.B."/>
                <person name="Kuwabara P.E."/>
            </authorList>
            <dbReference type="PubMed" id="10783162"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CLEAVAGE BY TRA-3</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2000" name="Genes Dev." volume="14" first="3153" last="3165">
            <title>Direct protein-protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans.</title>
            <authorList>
                <person name="Lum D.H."/>
                <person name="Kuwabara P.E."/>
                <person name="Zarkower D."/>
                <person name="Spence A.M."/>
            </authorList>
            <dbReference type="PubMed" id="11124807"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH TRA-1</scope>
        <scope>MUTAGENESIS OF CYS-1392; GLU-1393 AND ARG-1400</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2001" name="EMBO J." volume="20" first="1363" last="1372">
            <title>The TRA-1 transcription factor binds TRA-2 to regulate sexual fates in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wang S."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="11250902"/>
            <dbReference type="DOI" id="10.1093/emboj/20.6.1363"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH TRA-1</scope>
        <scope>MUTAGENESIS OF GLU-1393; ARG-1400 AND PRO-1411</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2002" name="Curr. Biol." volume="12" first="2035" last="2041">
            <title>Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2.</title>
            <authorList>
                <person name="Haag E.S."/>
                <person name="Wang S."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="12477393"/>
            <dbReference type="DOI" id="10.1016/S0960-9822(02)01333-7"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH FEM-3</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2002" name="Genetics" volume="161" first="99" last="107">
            <title>Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis.</title>
            <authorList>
                <person name="Graustein A."/>
                <person name="Gaspar J.M."/>
                <person name="Walters J.R."/>
                <person name="Palopoli M.F."/>
            </authorList>
            <dbReference type="PubMed" id="12019226"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-142</scope>
        <source>
            <strain>AB1</strain>
            <strain>AB2</strain>
            <strain>CB4507</strain>
            <strain>CB4851</strain>
            <strain>CB4852</strain>
            <strain>CB4853</strain>
            <strain>CB4854</strain>
            <strain>CB4855</strain>
            <strain>CB4856</strain>
            <strain>CB4857</strain>
            <strain>CB4858</strain>
            <strain>CB4932</strain>
            <strain>DH424</strain>
            <strain>DR1344</strain>
            <strain>PB303</strain>
            <strain>PB305</strain>
            <strain>PB306</strain>
            <strain>PB307</strain>
            <strain>TR388</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <event type="alternative initiation"/>
        <isoform>
            <id>P34709-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_011746 VSP_011747"/>
        </isoform>
        <isoform>
            <id>P34709-3</id>
            <name>Tra-2B</name>
            <sequence type="described" ref="VSP_018823"/>
        </isoform>
        <isoform>
            <id>P34709-1</id>
            <name>Tra-2A</name>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Produced by alternative initiation at Met-1089 of isoform Tra-2A.</text>
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    <dbReference type="RefSeq" id="NP_001367508.1">
        <property type="nucleotide sequence ID" value="NM_001381483.1"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Caenorhabditis</taxon>
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        <citation type="submission" date="1997-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ernsting B.R."/>
                <person name="Li L."/>
                <person name="Wishart M.J."/>
                <person name="Dixon J.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C)</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="J. Cell Biol." volume="158" first="901" last="914">
            <title>The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo.</title>
            <authorList>
                <person name="Gruneberg U."/>
                <person name="Glotzer M."/>
                <person name="Gartner A."/>
                <person name="Nigg E.A."/>
            </authorList>
            <dbReference type="PubMed" id="12213836"/>
            <dbReference type="DOI" id="10.1083/jcb.200202054"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-295</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Nat. Cell Biol." volume="6" first="777" last="783">
            <title>The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans.</title>
            <authorList>
                <person name="Saito R.M."/>
                <person name="Perreault A."/>
                <person name="Peach B."/>
                <person name="Satterlee J.S."/>
                <person name="van den Heuvel S."/>
            </authorList>
            <dbReference type="PubMed" id="15247923"/>
            <dbReference type="DOI" id="10.1038/ncb1154"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; C; D AND E)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 446-GLN--SER-709</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Mech. Dev." volume="128" first="317" last="326">
            <title>Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Roy S.H."/>
                <person name="Clayton J.E."/>
                <person name="Holmen J."/>
                <person name="Beltz E."/>
                <person name="Saito R.M."/>
            </authorList>
            <dbReference type="PubMed" id="21723944"/>
            <dbReference type="DOI" id="10.1016/j.mod.2011.06.001"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION (ISOFORM C)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>NUCLEAR EXPORT SIGNAL</scope>
        <scope>NUCLEAR LOCALIZATION SIGNAL</scope>
        <scope>MUTAGENESIS OF 366-LYS--ARG-371 AND 372-LEU--LEU-381</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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            <sequence type="displayed"/>
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            <id>P81299-4</id>
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            <id>P81299-5</id>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10044"/>
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    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="12213836"/>
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        <source>
            <dbReference type="PubMed" id="12213836"/>
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        <source>
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        <source>
            <dbReference type="WormBase" id="C17G10.4a"/>
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    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C17G10.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="C17G10.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="C17G10.4h"/>
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    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2003-04-30" modified="2026-01-28" version="182" xmlns="https://uniprot.org/uniprot">
    <accession>P81299-3</accession>
    <name>CDC14_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Tyrosine-protein phosphatase cdc-14</fullName>
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        <alternativeName>
            <fullName>Cell division cycle-related protein 14</fullName>
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    <gene>
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        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Rhabditida</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="1997-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ernsting B.R."/>
                <person name="Li L."/>
                <person name="Wishart M.J."/>
                <person name="Dixon J.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C)</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="J. Cell Biol." volume="158" first="901" last="914">
            <title>The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo.</title>
            <authorList>
                <person name="Gruneberg U."/>
                <person name="Glotzer M."/>
                <person name="Gartner A."/>
                <person name="Nigg E.A."/>
            </authorList>
            <dbReference type="PubMed" id="12213836"/>
            <dbReference type="DOI" id="10.1083/jcb.200202054"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-295</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Nat. Cell Biol." volume="6" first="777" last="783">
            <title>The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans.</title>
            <authorList>
                <person name="Saito R.M."/>
                <person name="Perreault A."/>
                <person name="Peach B."/>
                <person name="Satterlee J.S."/>
                <person name="van den Heuvel S."/>
            </authorList>
            <dbReference type="PubMed" id="15247923"/>
            <dbReference type="DOI" id="10.1038/ncb1154"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; C; D AND E)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 446-GLN--SER-709</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Mech. Dev." volume="128" first="317" last="326">
            <title>Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Roy S.H."/>
                <person name="Clayton J.E."/>
                <person name="Holmen J."/>
                <person name="Beltz E."/>
                <person name="Saito R.M."/>
            </authorList>
            <dbReference type="PubMed" id="21723944"/>
            <dbReference type="DOI" id="10.1016/j.mod.2011.06.001"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION (ISOFORM C)</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>NUCLEAR EXPORT SIGNAL</scope>
        <scope>NUCLEAR LOCALIZATION SIGNAL</scope>
        <scope>MUTAGENESIS OF 366-LYS--ARG-371 AND 372-LEU--LEU-381</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Main regulator of cell cycle arrest in vulval precursor cells.</text>
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            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <text evidence="3">Localizes to the cytoplasm during interphase, but localizes to the nucleus during cell cycle arrest.</text>
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            <sequence type="described" ref="VSP_059807 VSP_059808"/>
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            <id>P81299-7</id>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="Swiss-Prot" created="2003-04-30" modified="2026-01-28" version="182" xmlns="https://uniprot.org/uniprot">
    <accession>P81299-4</accession>
    <name>CDC14_CAEEL</name>
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        <recommendedName>
            <fullName>Isoform d of Tyrosine-protein phosphatase cdc-14</fullName>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="1997-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ernsting B.R."/>
                <person name="Li L."/>
                <person name="Wishart M.J."/>
                <person name="Dixon J.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C)</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="J. Cell Biol." volume="158" first="901" last="914">
            <title>The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo.</title>
            <authorList>
                <person name="Gruneberg U."/>
                <person name="Glotzer M."/>
                <person name="Gartner A."/>
                <person name="Nigg E.A."/>
            </authorList>
            <dbReference type="PubMed" id="12213836"/>
            <dbReference type="DOI" id="10.1083/jcb.200202054"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-295</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Nat. Cell Biol." volume="6" first="777" last="783">
            <title>The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans.</title>
            <authorList>
                <person name="Saito R.M."/>
                <person name="Perreault A."/>
                <person name="Peach B."/>
                <person name="Satterlee J.S."/>
                <person name="van den Heuvel S."/>
            </authorList>
            <dbReference type="PubMed" id="15247923"/>
            <dbReference type="DOI" id="10.1038/ncb1154"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; C; D AND E)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 446-GLN--SER-709</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Mech. Dev." volume="128" first="317" last="326">
            <title>Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Roy S.H."/>
                <person name="Clayton J.E."/>
                <person name="Holmen J."/>
                <person name="Beltz E."/>
                <person name="Saito R.M."/>
            </authorList>
            <dbReference type="PubMed" id="21723944"/>
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        <scope>NUCLEAR EXPORT SIGNAL</scope>
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                <person name="Li L."/>
                <person name="Wishart M.J."/>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain>Bristol N2</strain>
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        <citation type="journal article" date="2002" name="J. Cell Biol." volume="158" first="901" last="914">
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            <dbReference type="DOI" id="10.1083/jcb.200202054"/>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-295</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Nat. Cell Biol." volume="6" first="777" last="783">
            <title>The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans.</title>
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        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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                <person name="Clayton J.E."/>
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        <scope>SUBCELLULAR LOCATION (ISOFORM C)</scope>
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        <scope>NUCLEAR EXPORT SIGNAL</scope>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference key="3">
        <citation type="journal article" date="2002" name="J. Cell Biol." volume="158" first="901" last="914">
            <title>The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo.</title>
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        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-295</scope>
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    <reference key="4">
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            <title>The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans.</title>
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        <scope>FUNCTION</scope>
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                <person name="Waaijers S."/>
                <person name="Munoz J."/>
                <person name="Berends C."/>
                <person name="Ramalho J.J."/>
                <person name="Goerdayal S.S."/>
                <person name="Low T.Y."/>
                <person name="Zoumaro-Djayoon A.D."/>
                <person name="Hoffmann M."/>
                <person name="Koorman T."/>
                <person name="Tas R.P."/>
                <person name="Harterink M."/>
                <person name="Seelk S."/>
                <person name="Kerver J."/>
                <person name="Hoogenraad C.C."/>
                <person name="Bossinger O."/>
                <person name="Tursun B."/>
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            <dbReference type="DOI" id="10.1186/s12915-016-0286-x"/>
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        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
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        <property type="gene designation" value="maph-1.1"/>
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    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F32A7.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="F32A7.5c"/>
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    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F32A7.5d"/>
        </source>
    </evidence>
    <sequence length="764" mass="80276" checksum="4328DA5142855306" modified="1997-05-01" version="1"> </sequence>
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<entry dataset="Swiss-Prot" created="2017-07-05" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>P91859-3</accession>
    <name>MAP11_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform c of Microtubule-associated protein homolog maph-1.1</fullName>
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        <name evidence="1 4" type="primary">maph-1.1</name>
        <name evidence="4" type="ORF">F32A7.5</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="BMC Biol." volume="14" first="66" last="66">
            <title>A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large.</title>
            <authorList>
                <person name="Waaijers S."/>
                <person name="Munoz J."/>
                <person name="Berends C."/>
                <person name="Ramalho J.J."/>
                <person name="Goerdayal S.S."/>
                <person name="Low T.Y."/>
                <person name="Zoumaro-Djayoon A.D."/>
                <person name="Hoffmann M."/>
                <person name="Koorman T."/>
                <person name="Tas R.P."/>
                <person name="Harterink M."/>
                <person name="Seelk S."/>
                <person name="Kerver J."/>
                <person name="Hoogenraad C.C."/>
                <person name="Bossinger O."/>
                <person name="Tursun B."/>
                <person name="van den Heuvel S."/>
                <person name="Heck A.J."/>
                <person name="Boxem M."/>
            </authorList>
            <dbReference type="PubMed" id="27506200"/>
            <dbReference type="DOI" id="10.1186/s12915-016-0286-x"/>
        </citation>
        <scope>INTERACTION WITH DLG-1</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P91859-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_058989"/>
        </isoform>
        <isoform>
            <id>P91859-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_058990 VSP_058991"/>
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        <isoform>
            <id>P91859-1</id>
            <name evidence="4">a</name>
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        </isoform>
        <isoform>
            <id>P91859-3</id>
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    <dbReference type="RefSeq" id="NP_001021438.1">
        <property type="nucleotide sequence ID" value="NM_001026267.3"/>
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    <dbReference type="WormBase" id="F32A7.5c">
        <property type="protein sequence ID" value="CE34179"/>
        <property type="gene ID" value="WBGene00009306"/>
        <property type="gene designation" value="maph-1.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
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    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="27506200"/>
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    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F32A7.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F32A7.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F32A7.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F32A7.5d"/>
        </source>
    </evidence>
    <sequence length="877" mass="92181" checksum="269CA82D440A6B0A" modified="1997-05-01" version="1"> </sequence>
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<entry dataset="Swiss-Prot" created="2017-07-05" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>P91859-4</accession>
    <name>MAP11_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform d of Microtubule-associated protein homolog maph-1.1</fullName>
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    <gene>
        <name evidence="1 4" type="primary">maph-1.1</name>
        <name evidence="4" type="ORF">F32A7.5</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="BMC Biol." volume="14" first="66" last="66">
            <title>A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large.</title>
            <authorList>
                <person name="Waaijers S."/>
                <person name="Munoz J."/>
                <person name="Berends C."/>
                <person name="Ramalho J.J."/>
                <person name="Goerdayal S.S."/>
                <person name="Low T.Y."/>
                <person name="Zoumaro-Djayoon A.D."/>
                <person name="Hoffmann M."/>
                <person name="Koorman T."/>
                <person name="Tas R.P."/>
                <person name="Harterink M."/>
                <person name="Seelk S."/>
                <person name="Kerver J."/>
                <person name="Hoogenraad C.C."/>
                <person name="Bossinger O."/>
                <person name="Tursun B."/>
                <person name="van den Heuvel S."/>
                <person name="Heck A.J."/>
                <person name="Boxem M."/>
            </authorList>
            <dbReference type="PubMed" id="27506200"/>
            <dbReference type="DOI" id="10.1186/s12915-016-0286-x"/>
        </citation>
        <scope>INTERACTION WITH DLG-1</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P91859-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_058990 VSP_058991"/>
        </isoform>
        <isoform>
            <id>P91859-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_058992"/>
        </isoform>
        <isoform>
            <id>P91859-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_058989"/>
        </isoform>
        <isoform>
            <id>P91859-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
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    </comment>
    <dbReference type="RefSeq" id="NP_001252456.1">
        <property type="nucleotide sequence ID" value="NM_001265527.4"/>
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    <dbReference type="WormBase" id="F32A7.5d">
        <property type="protein sequence ID" value="CE47031"/>
        <property type="gene ID" value="WBGene00009306"/>
        <property type="gene designation" value="maph-1.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="27506200"/>
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    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F32A7.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F32A7.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F32A7.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F32A7.5d"/>
        </source>
    </evidence>
    <sequence length="819" mass="85883" checksum="AF040AFA4BF3A7AA" modified="1997-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>Q18066-2</accession>
    <name>DIM_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Disorganized muscle protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>2D-page protein spot 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">dim-1</name>
        <name type="ORF">C18A11.7/C18A11.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Electrophoresis" volume="18" first="557" last="562">
            <title>Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates and identification of protein spots by microsequencing.</title>
            <authorList>
                <person name="Bini L."/>
                <person name="Heid H."/>
                <person name="Liberatori S."/>
                <person name="Geier G."/>
                <person name="Pallini V."/>
                <person name="Zwilling R."/>
            </authorList>
            <dbReference type="PubMed" id="9150941"/>
            <dbReference type="DOI" id="10.1002/elps.1150180337"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 318-327 (ISOFORM B)</scope>
        <scope>CLEAVAGE OF INITIATOR METHIONINE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Genetics" volume="163" first="905" last="915">
            <title>DIM-1, a novel immunoglobulin superfamily protein in Caenorhabditis elegans, is necessary for maintaining bodywall muscle integrity.</title>
            <authorList>
                <person name="Rogalski T.M."/>
                <person name="Gilbert M.M."/>
                <person name="Devenport D."/>
                <person name="Norman K.R."/>
                <person name="Moerman D.G."/>
            </authorList>
            <dbReference type="PubMed" id="12663531"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative promoter"/>
        <isoform>
            <id>Q18066-1</id>
            <name>a</name>
            <name>Long</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q18066-2</id>
            <name>b</name>
            <name>Short</name>
            <sequence type="described" ref="VSP_009228"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024421.1">
        <property type="nucleotide sequence ID" value="NM_001029250.5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="324" mass="35539" checksum="CDBEF0FEF8336A3E" modified="2004-01-16" version="3">MPDGKAPHFPQQPVARQNDDGSLELECFVDANPTPQVKWYYDNKEVENSGRFSANLANKGSDSYSAILTIKELADADAGAYRCAIVNPHGKGNANFNLKLTGFSSPTFVEKPQISSRDDGQVMVMEFRAKSILEPTFVWQKLVGGGAEEIIANSDRIKAVKKLEAGNVYYSALEIKEPTKDKDAGQFICTVKNESGKLTATFTVKFEVPEGAPSFTRKPQILQQTSAGGEPAICFDIGYSARMNPQVTWISPKSKKMKESSRIKFKTNDEGNGNFTAQLELTNYKAKDSGTYTCNIKNDAGEANVELTLNIEGPLDDYADDSEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-08-10" modified="2026-01-28" version="189" xmlns="https://uniprot.org/uniprot">
    <accession>Q19469-2</accession>
    <name>SAD1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isoform b of Serine/threonine kinase SAD-1</fullName>
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        <alternativeName>
            <fullName evidence="4">Synapses of Amphids Defective</fullName>
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    <gene>
        <name evidence="8" type="primary">sad-1</name>
        <name type="ORF">F15A2.6</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="7">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2001" name="Neuron" volume="29" first="115" last="129">
            <title>The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination.</title>
            <authorList>
                <person name="Crump J.G."/>
                <person name="Zhen M."/>
                <person name="Jin Y."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="11182085"/>
            <dbReference type="DOI" id="10.1016/S0896-6273(01)00184-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2007" name="Development" volume="134" first="237" last="249">
            <title>Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hung W."/>
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                <person name="Narbonne P."/>
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    <dbReference type="SMR" id="Q1XFY3"/>
    <dbReference type="GeneID" id="180946"/>
    <dbReference type="UCSC" id="H22K11.4b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019227"/>
    <dbReference type="CTD" id="180946"/>
    <dbReference type="WormBase" id="H22K11.4b">
        <property type="protein sequence ID" value="CE40082"/>
        <property type="gene ID" value="WBGene00019227"/>
        <property type="gene designation" value="sgca-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048167_0_0_1"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019227">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1XFY3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016012">
        <property type="term" value="C:sarcoglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008908">
        <property type="entry name" value="Sarcoglycan_alpha/epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10132">
        <property type="entry name" value="ALPHA-/EPSILON-SARCOGLYCAN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10132:SF14">
        <property type="entry name" value="SARCOGLYCAN ALPHA, ISOFORM C"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD72419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="H22K11.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q1XFY3"/>
        </source>
    </evidence>
    <sequence length="348" mass="39176" checksum="7C937223E4AE1050" modified="2006-05-02" version="1">MVVINLVEDSLYQGNTQQVFELPINGLDVEDLVSNRDRKISQLENSLRNTFRGRNVNPYIAGVRSRYIIPRGKEHIFKNSFGTMVYVGTQQKFYPGTMSIVHNLQTMPEFCSNPSSVVMNKYFAPTFPVDWCNVAVRNISSLEGEGIDELIKDEQEEKLTKANPDQNLNEKPEQPPRELYGYSEHGFSIVLFAIILGVSILFVFALVLIFFGSREGQKWRDDKTSGETLGEFISIRDNQKKLRELSLQRQLLSMGPDTNSTAPSGIHSYLQSRSRAPSTSIARFSKSASRLNDKEDTIELLPSVDHVPVGKQTVAEAAKQCGSSLHLYRNPLSNESDEQDTESSDEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-05-02" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q1XFY7</accession>
    <name>Q1XFY7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F49D11.3</name>
        <name evidence="1 3" type="ORF">F49D11.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD71535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040667.1">
        <property type="nucleotide sequence ID" value="NM_001047202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1XFY7"/>
    <dbReference type="SMR" id="Q1XFY7"/>
    <dbReference type="GeneID" id="186032"/>
    <dbReference type="UCSC" id="F49D11.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018627"/>
    <dbReference type="CTD" id="186032"/>
    <dbReference type="WormBase" id="F49D11.3b">
        <property type="protein sequence ID" value="CE40066"/>
        <property type="gene ID" value="WBGene00018627"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069458_0_0_1"/>
    <dbReference type="OrthoDB" id="408912at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018627">
        <property type="expression patterns" value="Expressed in embryo and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1XFY7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF3">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD71535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F49D11.3b"/>
        </source>
    </evidence>
    <sequence length="238" mass="28283" checksum="185E9DCE92364866" modified="2006-05-02" version="1">MTQLTMNIMCLLYNETQFYDDNQSLNDTWLTERKCLENDDFIYPTESLENDIETARFAFIRDPIQRFVSLYLNKCVREKSCYNCGDDMRCTVWKIYEGLKKIQDHWDGHSEIGFMEGHAAPLSWNCDFDKDLPKWQLLMMGADSNERKSSILHLANILKKQGVKQELVEKIQEDMIAGETGHSTHKSAERIEAERQVREDPFIRDLLHKIYFFDYVVFPFKRDHLDPKYQSNFWTLPK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-01-20" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q20026-2</accession>
    <name>CTL1L_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Choline transporter-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">chtl-1</name>
        <name type="ORF">F35C8.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q20026-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_036155"/>
        </isoform>
        <isoform>
            <id>Q20026-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_036154"/>
        </isoform>
        <isoform>
            <id>Q20026-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741790.2">
        <property type="nucleotide sequence ID" value="NM_171686.5"/>
    </dbReference>
    <dbReference type="WormBase" id="F35C8.7b">
        <property type="protein sequence ID" value="CE30970"/>
        <property type="gene ID" value="WBGene00018037"/>
        <property type="gene designation" value="chtl-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="730" mass="82686" checksum="3AA855D3F5E0210F" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-01-20" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q20026-3</accession>
    <name>CTL1L_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Choline transporter-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">chtl-1</name>
        <name type="ORF">F35C8.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q20026-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_036154"/>
        </isoform>
        <isoform>
            <id>Q20026-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_036155"/>
        </isoform>
        <isoform>
            <id>Q20026-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367417.1">
        <property type="nucleotide sequence ID" value="NM_001380967.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F35C8.7c">
        <property type="protein sequence ID" value="CE42729"/>
        <property type="gene ID" value="WBGene00018037"/>
        <property type="gene designation" value="chtl-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="773" mass="87508" checksum="A8DCA2EE3ABF0691" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q20432-2</accession>
    <name>CNEP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of CTD nuclear envelope phosphatase 1 homolog</fullName>
            <shortName>CTDNEP1</shortName>
            <ecNumber>3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Serine/threonine-protein phosphatase dullard homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Small C-terminal domain phosphatase-like phosphatase 21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">cnep-1</name>
        <name type="synonym">scpl-2</name>
        <name type="ORF">F45E12.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Biochem. Biophys. Res. Commun." volume="295" first="85" last="91">
            <title>Molecular cloning and characterization of dullard: a novel gene required for neural development.</title>
            <authorList>
                <person name="Satow R."/>
                <person name="Chan T.C."/>
                <person name="Asashima M."/>
            </authorList>
            <dbReference type="PubMed" id="12083771"/>
            <dbReference type="DOI" id="10.1016/S0006-291X(02)00641-1"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Biol. Chem." volume="287" first="3123" last="3137">
            <title>Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is the metazoan SPO7 ortholog and functions in the lipin activation pathway.</title>
            <authorList>
                <person name="Han S."/>
                <person name="Bahmanyar S."/>
                <person name="Zhang P."/>
                <person name="Grishin N."/>
                <person name="Oegema K."/>
                <person name="Crooke R."/>
                <person name="Graham M."/>
                <person name="Reue K."/>
                <person name="Dixon J.E."/>
                <person name="Goodman J.M."/>
            </authorList>
            <dbReference type="PubMed" id="22134922"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.324350"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2020" name="J. Cell Biol." volume="219" first="0" last="0">
            <title>Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure.</title>
            <authorList>
                <person name="Penfield L."/>
                <person name="Shankar R."/>
                <person name="Szentgyoergyi E."/>
                <person name="Laffitte A."/>
                <person name="Mauro M.S."/>
                <person name="Audhya A."/>
                <person name="Mueller-Reichert T."/>
                <person name="Bahmanyar S."/>
            </authorList>
            <dbReference type="PubMed" id="32271860"/>
            <dbReference type="DOI" id="10.1083/jcb.201908179"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2022" name="Elife" volume="11" first="0" last="0">
            <title>Ndc1 drives nuclear pore complex assembly independent of membrane biogenesis to promote nuclear formation and growth.</title>
            <authorList>
                <person name="Mauro M.S."/>
                <person name="Celma G."/>
                <person name="Zimyanin V."/>
                <person name="Magaj M.M."/>
                <person name="Gibson K.H."/>
                <person name="Redemann S."/>
                <person name="Bahmanyar S."/>
            </authorList>
            <dbReference type="PubMed" id="35852146"/>
            <dbReference type="DOI" id="10.7554/elife.75513"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q20432-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q20432-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_056100"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.3.16"/>
    <dbReference type="RefSeq" id="NP_001254123.1">
        <property type="nucleotide sequence ID" value="NM_001267194.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F45E12.1b">
        <property type="protein sequence ID" value="CE46930"/>
        <property type="gene ID" value="WBGene00018474"/>
        <property type="gene designation" value="cnep-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="276" mass="31895" checksum="1C1AE11E1C600915" modified="1996-11-01" version="1">MYVPNRQFGGGNPESHRRRDQKQASLVLRTMTTIAQSVFCFLAGFFNFFLLYFRKTSRAYCKYQVVKYHSNIPMSPLTTHRLLTVKRKILVLDLDETLIHSHHDGVLRQTVKPGTPSDFTIRVVIDRHPVKFSVHERPHVDYFLSVVSQWYELVVFTASMEVYGTSVADRLDRGRGILKRRYFRQHCTMEVGGYTKDLSAIHPDLSSICILDNSPGAYRKFPHNAIPIPSWFSDPNDTCLLNLLPFLDALRFTSDVRSVLSRNMQALPETQSVQYY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-02-21" modified="2026-01-28" version="180" xmlns="https://uniprot.org/uniprot">
    <accession>Q21153-2</accession>
    <name>CMC1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Probable calcium-binding mitochondrial carrier K02F3.2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">K02F3.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21153-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_053225"/>
        </isoform>
        <isoform>
            <id>Q21153-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_497274.3">
        <property type="nucleotide sequence ID" value="NM_064873.6"/>
    </dbReference>
    <dbReference type="WormBase" id="K02F3.2a">
        <property type="protein sequence ID" value="CE48021"/>
        <property type="gene ID" value="WBGene00019326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="708" mass="78727" checksum="08EF7F94A4B0B1B1" modified="2013-10-16" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2026-01-28" version="176" xmlns="https://uniprot.org/uniprot">
    <accession>Q21286-2</accession>
    <name>CATP5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform a of Cation-transporting ATPase catp-5</fullName>
            <ecNumber>7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">catp-5</name>
        <name evidence="3" type="ORF">K07E3.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="FASEB J." volume="24" first="206" last="217">
            <title>Caenorhabditis elegans P5B-type ATPase CATP-5 operates in polyamine transport and is crucial for norspermidine-mediated suppression of RNA interference.</title>
            <authorList>
                <person name="Heinick A."/>
                <person name="Urban K."/>
                <person name="Roth S."/>
                <person name="Spies D."/>
                <person name="Nunes F."/>
                <person name="Phanstiel O. IV"/>
                <person name="Liebau E."/>
                <person name="Lueersen K."/>
            </authorList>
            <dbReference type="PubMed" id="19762559"/>
            <dbReference type="DOI" id="10.1096/fj.09-135889"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21286-2</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_012458"/>
        </isoform>
        <isoform>
            <id>Q21286-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="7.2.2.-"/>
    <dbReference type="RefSeq" id="NP_001379600.1">
        <property type="nucleotide sequence ID" value="NM_001392807.1"/>
    </dbReference>
    <dbReference type="WormBase" id="K07E3.7a">
        <property type="protein sequence ID" value="CE37253"/>
        <property type="gene ID" value="WBGene00019493"/>
        <property type="gene designation" value="catp-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="19762559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="K07E3.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="K07E3.7b"/>
        </source>
    </evidence>
    <sequence length="1174" mass="131352" checksum="136A66790C63D166" modified="2005-01-04" version="4"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-06-06" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>Q21955-2</accession>
    <name>MED15_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Mediator of RNA polymerase II transcription subunit 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mdt-15</name>
        <name type="ORF">R12B2.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Genes Dev." volume="20" first="1137" last="1149">
            <title>A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans.</title>
            <authorList>
                <person name="Taubert S."/>
                <person name="Van Gilst M.R."/>
                <person name="Hansen M."/>
                <person name="Yamamoto K.R."/>
            </authorList>
            <dbReference type="PubMed" id="16651656"/>
            <dbReference type="DOI" id="10.1101/gad.1395406"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH NHR-49 AND NHR-64</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Nature" volume="442" first="700" last="704">
            <title>An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.</title>
            <authorList>
                <person name="Yang F."/>
                <person name="Vought B.W."/>
                <person name="Satterlee J.S."/>
                <person name="Walker A.K."/>
                <person name="Jim Sun Z.-Y."/>
                <person name="Watts J.L."/>
                <person name="DeBeaumont R."/>
                <person name="Saito R.M."/>
                <person name="Hyberts S.G."/>
                <person name="Yang S."/>
                <person name="Macol C."/>
                <person name="Iyer L."/>
                <person name="Tjian R."/>
                <person name="van den Heuvel S."/>
                <person name="Hart A.C."/>
                <person name="Wagner G."/>
                <person name="Naeaer A.M."/>
            </authorList>
            <dbReference type="PubMed" id="16799563"/>
            <dbReference type="DOI" id="10.1038/nature04942"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SBP-1</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2020" name="Biochem. Biophys. Res. Commun." volume="528" first="28" last="34">
            <title>Lipid metabolic sensors of MDT-15 and SBP-1 regulated the response to simulated microgravity in the intestine of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Liu H."/>
                <person name="Li D."/>
                <person name="Zhang R."/>
                <person name="Sun L."/>
                <person name="Wang D."/>
            </authorList>
            <dbReference type="PubMed" id="32448509"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2020.05.099"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21955-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020624"/>
        </isoform>
        <isoform>
            <id>Q21955-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741151.1">
        <property type="nucleotide sequence ID" value="NM_171134.9"/>
    </dbReference>
    <dbReference type="WormBase" id="R12B2.5b">
        <property type="protein sequence ID" value="CE25078"/>
        <property type="gene ID" value="WBGene00007016"/>
        <property type="gene designation" value="mdt-15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="777" mass="84230" checksum="489F9D46BA7F0BFC" modified="2002-03-01" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q65CL5</accession>
    <name>Q65CL5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">gei-4</name>
        <name evidence="3" type="ORF">CELE_W07B3.2</name>
        <name evidence="5" type="ORF">W07B3.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD72890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022811.1">
        <property type="nucleotide sequence ID" value="NM_001027640.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q65CL5"/>
    <dbReference type="SMR" id="Q65CL5"/>
    <dbReference type="PeptideAtlas" id="Q65CL5"/>
    <dbReference type="GeneID" id="175195"/>
    <dbReference type="KEGG" id="cel:CELE_W07B3.2"/>
    <dbReference type="UCSC" id="W07B3.2a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001561"/>
    <dbReference type="CTD" id="175195"/>
    <dbReference type="WormBase" id="W07B3.2f">
        <property type="protein sequence ID" value="CE37419"/>
        <property type="gene ID" value="WBGene00001561"/>
        <property type="gene designation" value="gei-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5816839at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001561">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q65CL5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040027">
        <property type="term" value="P:negative regulation of vulval development"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22084:SF4">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22084">
        <property type="entry name" value="GEX INTERACTING PROTEIN PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="482"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD72890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W07B3.2f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q65CL5"/>
        </source>
    </evidence>
    <sequence length="564" mass="65040" checksum="566A16D43AA4270C" modified="2004-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>Q65CM2</accession>
    <name>Q65CM2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">cdk-14</name>
        <name evidence="11" type="ORF">CELE_ZC123.4</name>
        <name evidence="13" type="ORF">ZC123.4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD73561.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001382290.1">
        <property type="nucleotide sequence ID" value="NM_001395342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q65CM2"/>
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    <dbReference type="IntAct" id="Q65CM2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="171672"/>
    <dbReference type="UCSC" id="ZC123.4c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022519"/>
    <dbReference type="CTD" id="171672"/>
    <dbReference type="WormBase" id="ZC123.4c">
        <property type="protein sequence ID" value="CE17302"/>
        <property type="gene ID" value="WBGene00022519"/>
        <property type="gene designation" value="cdk-14"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022519">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q65CM2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000524">
        <property type="entry name" value="Cell division protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000781">
        <property type="entry name" value="Protein CBG18552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF189">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="60"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD73561.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="ZC123.4c"/>
        </source>
    </evidence>
    <sequence length="378" mass="43145" checksum="7D7B1386662B862B" modified="2022-01-19" version="2">MSTVPLNKNSPSMPPPPSSNTVADFTHLRRRRPRSAHYDPNTITLPAKEEVTPQDVNDLYKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQEGLPFTAIREASLLRNLRHANIVSLHDIFYQHHQLTFVFEYMKMDLSKYLEQNVYGLDSIDIKLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVPSRTYSHEVVTLWYRPPDVLMGSTDYSTSLDMWGVGCIFAEICTGAALFPGSKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYTPELFPRYRELSFIAVNPMFTKILKTGQELLGMLLQLRPESRVSAASAMLHPYFASFPREVHLLAPSQSIFRLKELKDLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JKB8</accession>
    <name>Q7JKB8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_H01G02.3</name>
        <name evidence="3 5" type="ORF">H01G02.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAE46677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023251.1">
        <property type="nucleotide sequence ID" value="NM_001028080.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JKB8"/>
    <dbReference type="SMR" id="Q7JKB8"/>
    <dbReference type="GeneID" id="259600"/>
    <dbReference type="UCSC" id="H01G02.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010350"/>
    <dbReference type="CTD" id="259600"/>
    <dbReference type="WormBase" id="H01G02.3b">
        <property type="protein sequence ID" value="CE35569"/>
        <property type="gene ID" value="WBGene00010350"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106876_0_0_1"/>
    <dbReference type="OrthoDB" id="5802886at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010350">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JKB8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004287644" evidence="2">
        <location>
            <begin position="29"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE46677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="H01G02.3b"/>
        </source>
    </evidence>
    <sequence length="177" mass="19786" checksum="BF4851EB481B6EDC" modified="2004-07-05" version="1">MRPGRQRWRYHNQLLLLLLFLLPGVANSVKCYCTDDHCVPYGSCDGTVCLVGILRDSNQVIRTCGTNTLGCHKNEDDKWTDLCACDQPFCNTFAFLRTHTSRQEDSMSPADPHHDAPLVFHRMDRPDDGIPPPPPGLMEREGPNKTSLLTLLLVVVPLTVGAATVMVVAFNYYCHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JKG4</accession>
    <name>Q7JKG4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">snRNA-activating protein complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_K04B12.2</name>
        <name evidence="2 4" type="ORF">K04B12.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAE46672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JKG4"/>
    <dbReference type="SMR" id="Q7JKG4"/>
    <dbReference type="UCSC" id="K04B12.2b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010550"/>
    <dbReference type="WormBase" id="K04B12.2b">
        <property type="protein sequence ID" value="CE35577"/>
        <property type="gene ID" value="WBGene00010550"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_669452_0_0_1"/>
    <dbReference type="OrthoDB" id="5804320at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010550">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JKG4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAE46672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K04B12.2b"/>
        </source>
    </evidence>
    <sequence length="381" mass="43335" checksum="B06E72E33772CE38" modified="2004-07-05" version="1">MRLTSIDETLRALESRISTEVEHRVANAVQNILETDEIKNLINERVSEAVQAGSSSLNMPSSSSSSCTSSDSEESELSLPARSRTPSVCAERSTTGDEEPVPSCSVVPDIVALQTAPHYPNKWEFISSLLQNGPITDFKLDHFTNSVRSSLKMTSDQEVFPRMSLEEMIERDHPTTSESSLFDEKKISCHNRPKGKNLLDEEFFCLAPCCSGMRLFQAETYTFLPGFVKNRLKQADDCRVIVHKTSNGIELITPIKWQRVTPIFPENTKNIQPPDERIEEDEAEEEDPLANREIVEQLMHEYFIPTPALPLDDLVFGPYLQRVRESEPFPENLLHDLVRRVNSNLDNSYDSHQELELFDKLDEVPIDEKYGRLPFDPMDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q7YWP7</accession>
    <name>Q7YWP7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y47D3A.32</name>
        <name evidence="3 5" type="ORF">Y47D3A.32</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAE18010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255115.1">
        <property type="nucleotide sequence ID" value="NM_001268186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7YWP7"/>
    <dbReference type="GeneID" id="3564848"/>
    <dbReference type="UCSC" id="Y47D3A.32">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012938"/>
    <dbReference type="CTD" id="3564848"/>
    <dbReference type="WormBase" id="Y47D3A.32a">
        <property type="protein sequence ID" value="CE35091"/>
        <property type="gene ID" value="WBGene00012938"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2335522_0_0_1"/>
    <dbReference type="OrthoDB" id="10514677at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012938">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7YWP7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAE18010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y47D3A.32a"/>
        </source>
    </evidence>
    <sequence length="98" mass="11584" checksum="6A943667EA643494" modified="2003-10-01" version="1">MNETIIVDMWNVNATTGPTIISAKKEQLYESLILSGSAIIFILLAILILYYIKTSRYYRHWWRGRQCEKAAKKEEKARLKAKVEREKLEQEDEEEYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q7YX26</accession>
    <name>Q7YX26_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-alpha-acetyltransferase 60</fullName>
            <ecNumber evidence="7">2.3.1.259</ecNumber>
            <ecNumber evidence="1">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CELE_F30F8.10</name>
        <name evidence="12 14" type="ORF">F30F8.10</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-[transmembrane protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50604"/>
            <dbReference type="Rhea" id="RHEA-COMP:12745"/>
            <dbReference type="Rhea" id="RHEA-COMP:12746"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="ChEBI" id="CHEBI:133414"/>
            <dbReference type="EC" id="2.3.1.259"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetyltransferase family. NAA60 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.259" evidence="7"/>
    <dbReference type="EC" id="2.3.1.48" evidence="1"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAE17804.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122467.1">
        <property type="nucleotide sequence ID" value="NM_001128995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7YX26"/>
    <dbReference type="SMR" id="Q7YX26"/>
    <dbReference type="PaxDb" id="6239-F30F8.10a"/>
    <dbReference type="GeneID" id="3565178"/>
    <dbReference type="KEGG" id="cel:CELE_F30F8.10"/>
    <dbReference type="UCSC" id="F30F8.10a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009277"/>
    <dbReference type="CTD" id="3565178"/>
    <dbReference type="WormBase" id="F30F8.10a">
        <property type="protein sequence ID" value="CE41233"/>
        <property type="gene ID" value="WBGene00009277"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="Q7YX26"/>
    <dbReference type="OMA" id="IHFYKKM"/>
    <dbReference type="OrthoDB" id="47017at2759"/>
    <dbReference type="PhylomeDB" id="Q7YX26"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009277">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7YX26">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000290">
        <property type="entry name" value="Protein CBG23731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045141">
        <property type="entry name" value="NAA60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744:SF15">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="46"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAE17804.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F30F8.10a"/>
        </source>
    </evidence>
    <sequence length="242" mass="27253" checksum="9DB8D90E1FFDBC14" modified="2007-07-10" version="3">MEGTARLGWSFDQNARRSKGLWMESVDMTPSSSTHIQQPLALSDSFTLRRLQTWDRMAVEALCNESFPIQYPDCWYDEVVSGGLLSTGLFDGEQLAAMVVSETKFLYDCNLEDQGILPSSNAHVAYILSIAVDKKFRRLGLATRLLNNLMSSLSDHPPYPRAVFLHVLSTNSAALSFYKMHGFEFHASLPEYYRIGEQLADGCTYVKYINGTYTNVTFTDVCRTFGNTICMPLKAICKMLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q7YX42</accession>
    <name>Q7YX42_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CTCK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_F35B12.10</name>
        <name evidence="7 9" type="ORF">F35B12.10</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAE17778.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256341.1">
        <property type="nucleotide sequence ID" value="NM_001269412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7YX42"/>
    <dbReference type="GeneID" id="179595"/>
    <dbReference type="UCSC" id="F35B12.10">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009389"/>
    <dbReference type="CTD" id="179595"/>
    <dbReference type="WormBase" id="F35B12.10a">
        <property type="protein sequence ID" value="CE41317"/>
        <property type="gene ID" value="WBGene00009389"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_819491_0_0_1"/>
    <dbReference type="OrthoDB" id="10061784at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009389">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7YX42">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF4">
        <property type="entry name" value="BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CTCK" evidence="6">
        <location>
            <begin position="248"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAE17778.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F35B12.10a"/>
        </source>
    </evidence>
    <sequence length="339" mass="38093" checksum="5E18DF4441516C49" modified="2007-08-21" version="2">MKRKDGRGQQSLRTEDNNDESGCSGQREHESPTDSPIPTSNDDEATTAAAAMTNERSRTQRRSRRFSVLPSSHFPNTSASFYSLLKFQPLSSTFSWRHMYYAVFLICWIGSGVVAAPTDRNDRQPTVEILDGYVNYSVNGSSSVPTFQEISRNAFLQLKGTPVESRFRLGTAYQLESTEEVNHVNHVDHQSHVDHLTRHHRKKNRKPVGKLKKLGKDEHGDTVFEGRKHALLQLADPDALIMNQRCDGQKFKQRIRVDGCLTKVVVNRLCHGACASIFIPRMHSKKLKAAFRSCAACAPAEYDYVDITLDCPGRTPPTATKTIVKVKSCKCKEVRIAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I0Y7</accession>
    <name>Q8I0Y7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein aurora borealis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_ZK673.11</name>
        <name evidence="2 4" type="ORF">ZK673.11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAD59166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040834.1">
        <property type="nucleotide sequence ID" value="NM_001047369.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I0Y7"/>
    <dbReference type="SMR" id="Q8I0Y7"/>
    <dbReference type="GeneID" id="259463"/>
    <dbReference type="KEGG" id="cel:CELE_ZK673.11"/>
    <dbReference type="UCSC" id="ZK673.11a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00014065"/>
    <dbReference type="CTD" id="259463"/>
    <dbReference type="WormBase" id="ZK673.11a">
        <property type="protein sequence ID" value="CE33019"/>
        <property type="gene ID" value="WBGene00014065"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821915_0_0_1"/>
    <dbReference type="OrthoDB" id="5825563at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014065">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8I0Y7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD59166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZK673.11a"/>
        </source>
    </evidence>
    <sequence length="347" mass="38079" checksum="D0EA4CFB7945C8FC" modified="2003-03-01" version="1">MFCCTRAQRKKAAEKISGSLRKHDSGPMFARLEEFDVLTPLQTTPAVSIASGNYKNYGSSSPSTSSGSDSRIQLLPPILSSSSSDSPPPPRRPNHGKTLIVPLNASRYRSPMTMNLVGTPDSRLTSFECGTTKSCATIPEDDEDEMNELLSIDRTSLSVYEQPSGRYGYSAYNLCLPQPTPEFQSSSSGFSPMLPAPTYSPPSLPSESPASKPTKIDIPEAILNDRDDILDREDDHNEDQVSIYEFSRVSDPNSEHSSSNSISDSFYLNNFDVISSAANSQIFEASICGESDVASKFQLHRIEEESENGDEQSCAGAHDPLINSMTHSPSQFFPRSISQQFDMMRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I0Y8</accession>
    <name>Q8I0Y8_CAEEL</name>
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        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ntl-11</name>
        <name evidence="11" type="ORF">CELE_Y73F8A.25</name>
        <name evidence="13" type="ORF">Y73F8A.25</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAD59165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367046.1">
        <property type="nucleotide sequence ID" value="NM_001380548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I0Y8"/>
    <dbReference type="SMR" id="Q8I0Y8"/>
    <dbReference type="PeptideAtlas" id="Q8I0Y8"/>
    <dbReference type="GeneID" id="178432"/>
    <dbReference type="UCSC" id="Y73F8A.25b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013530"/>
    <dbReference type="CTD" id="178432"/>
    <dbReference type="WormBase" id="Y73F8A.25b">
        <property type="protein sequence ID" value="CE33000"/>
        <property type="gene ID" value="WBGene00013530"/>
        <property type="gene designation" value="ntl-11"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_861175_0_0_1"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013530">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8I0Y8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="243"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD59165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="Y73F8A.25b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q8I0Y8"/>
        </source>
    </evidence>
    <sequence length="323" mass="35790" checksum="1EB35E31CDD3A326" modified="2003-03-01" version="1">MLSVVEELNKQIDCDDQMSQSSDSAPPSEVSSDLELDTALDIRDGMTMPLVDLKDEVIEGCVDRILDGTTLTTSKSDMMIQFVRTALITHPQYDRLLQASVLDENIISFIRTNVKFAGAFLVRNALSEQDTCLLFKRYMRLCEGVNSTVHSLETVLKLSKEFIEHDKLTQEHREVVLAFVRHTIRTCEGDRTVRLVAMLVKKLLRERVLNVEDIAADVKPFTLKYTDNRECTALYQSMINMQNGGGGGGQENMTTSTTTTTTTTKSSSPNSLSTTTTTTSHNPGASATTTTTTVVKTCGPATFKQTSRKVVLQFKNPSQNAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I0Z2</accession>
    <name>Q8I0Z2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y48E1C.4</name>
        <name evidence="1 3" type="ORF">Y48E1C.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAD59168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_872006.1">
        <property type="nucleotide sequence ID" value="NM_182206.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I0Z2"/>
    <dbReference type="PeptideAtlas" id="Q8I0Z2"/>
    <dbReference type="GeneID" id="174984"/>
    <dbReference type="UCSC" id="Y48E1C.4b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013017"/>
    <dbReference type="CTD" id="174984"/>
    <dbReference type="WormBase" id="Y48E1C.4b">
        <property type="protein sequence ID" value="CE32978"/>
        <property type="gene ID" value="WBGene00013017"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5809659at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013017">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8I0Z2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD59168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y48E1C.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="Q8I0Z2"/>
        </source>
    </evidence>
    <sequence length="193" mass="22180" checksum="CE0DCC1241588A3F" modified="2003-03-01" version="1">MNLASRVSGFLTMTSRYSSLATLKPTVAAALAPNFQRSFSDQKPTSTAPSTSTLLKVDWLLQKITPLVLKSNVRDFMDICKDDVQFDDRIFSKKLGGRTQLMSHIAKVRMYYRYLSPFNKVEWIGSCVYENEDVIVVMWRLTTLDSSFMSYFPSFITKKENKMIVKEGALDVQIDREGHVLRIVNRPVLLFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I0Z6</accession>
    <name>Q8I0Z6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-rich adhesin for platelets</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y48C3A.5</name>
        <name evidence="3 5" type="ORF">Y48C3A.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAD57712.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_496810.3">
        <property type="nucleotide sequence ID" value="NM_064409.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I0Z6"/>
    <dbReference type="GeneID" id="174973"/>
    <dbReference type="UCSC" id="Y48C3A.5a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012989"/>
    <dbReference type="CTD" id="174973"/>
    <dbReference type="WormBase" id="Y48C3A.5a">
        <property type="protein sequence ID" value="CE38245"/>
        <property type="gene ID" value="WBGene00012989"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033105_0_0_1"/>
    <dbReference type="OrthoDB" id="6247020at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012989">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8I0Z6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD57712.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y48C3A.5a"/>
        </source>
    </evidence>
    <sequence length="587" mass="66782" checksum="1AF94BA13B170885" modified="2005-04-26" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2025-10-08" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I0Z7</accession>
    <name>Q8I0Z7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">efhd-1</name>
        <name evidence="6" type="ORF">CELE_Y48B6A.6</name>
        <name evidence="8" type="ORF">Y48B6A.6</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
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        <property type="protein sequence ID" value="CAD59175.2"/>
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    <dbReference type="RefSeq" id="NP_871966.2">
        <property type="nucleotide sequence ID" value="NM_182166.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I0Z7"/>
    <dbReference type="SMR" id="Q8I0Z7"/>
    <dbReference type="PeptideAtlas" id="Q8I0Z7"/>
    <dbReference type="GeneID" id="175073"/>
    <dbReference type="UCSC" id="Y48B6A.6a.1">
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    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012980"/>
    <dbReference type="CTD" id="175073"/>
    <dbReference type="WormBase" id="Y48B6A.6b">
        <property type="protein sequence ID" value="CE41852"/>
        <property type="gene ID" value="WBGene00012980"/>
        <property type="gene designation" value="efhd-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025467_0_0_1"/>
    <dbReference type="OrthoDB" id="6572480at2759"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012980">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8I0Z7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000112">
        <property type="entry name" value="EF-hand domain family, member D2"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040365">
        <property type="entry name" value="EFHD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025:SF6">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00018">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
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            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
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            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAD59175.2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y48B6A.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q8I0Z7"/>
        </source>
    </evidence>
    <sequence length="203" mass="23695" checksum="8C3FB9E17D6394B2" modified="2008-01-15" version="2">MKTEDTKPVETAPAPVDEAELNDALDRRNKINEGENVPLKMNKKISLYAEFSEFSRKQIQYFSGIFKKYDEDQDSYIDFNELKRMMEKLGEAQTHIALKELIKKVDEDQDGKISQREFFLIFRLAASGELSCSEVFKTLAESVDVSKEGVLGAANFFQAKIEEQTKLSRFEEEMKEEKEEKKRQEEEKRARREKFLASKSIFH</sequence>
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<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="173" xmlns="https://uniprot.org/uniprot">
    <accession>Q94131-2</accession>
    <name>PIE1_CAEEL</name>
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        <recommendedName>
            <fullName>Isoform b of Pharynx and intestine in excess protein 1</fullName>
            <shortName>Protein pie-1</shortName>
        </recommendedName>
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        <name evidence="2" type="primary">pie-1</name>
        <name evidence="2" type="synonym">pic-1</name>
        <name evidence="2" type="ORF">Y49E10.14</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Cell" volume="70" first="163" last="176">
            <title>The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos.</title>
            <authorList>
                <person name="Mello C.C."/>
                <person name="Draper B.W."/>
                <person name="Krause M."/>
                <person name="Weintraub H."/>
                <person name="Priess J.R."/>
            </authorList>
            <dbReference type="PubMed" id="1623520"/>
            <dbReference type="DOI" id="10.1016/0092-8674(92)90542-K"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="Nature" volume="382" first="710" last="712">
            <title>The PIE-1 protein and germline specification in C. elegans embryos.</title>
            <authorList>
                <person name="Mello C.C."/>
                <person name="Schubert C."/>
                <person name="Draper B."/>
                <person name="Zhang W."/>
                <person name="Lobel R."/>
                <person name="Priess J.R."/>
            </authorList>
            <dbReference type="PubMed" id="8751440"/>
            <dbReference type="DOI" id="10.1038/382710a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1996" name="Nature" volume="382" first="713" last="716">
            <title>Repression of gene expression in the embryonic germ lineage of C. elegans.</title>
            <authorList>
                <person name="Seydoux G."/>
                <person name="Mello C.C."/>
                <person name="Pettitt J."/>
                <person name="Wood W.B."/>
                <person name="Priess J.R."/>
                <person name="Fire A."/>
            </authorList>
            <dbReference type="PubMed" id="8751441"/>
            <dbReference type="DOI" id="10.1038/382713a0"/>
        </citation>
        <scope>CHARACTERIZATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="Mol. Cell" volume="6" first="445" last="455">
            <title>Asymmetric segregation of PIE-1 in C. elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domains.</title>
            <authorList>
                <person name="Reese K.J."/>
                <person name="Dunn M.A."/>
                <person name="Waddle J.A."/>
                <person name="Seydoux G."/>
            </authorList>
            <dbReference type="PubMed" id="10983990"/>
            <dbReference type="DOI" id="10.1016/S1097-2765(00)00043-5"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>JJ532</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2001" name="Genes Dev." volume="15" first="1031" last="1040">
            <title>PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tenenhaus C."/>
                <person name="Subramaniam K."/>
                <person name="Dunn M.A."/>
                <person name="Seydoux G."/>
            </authorList>
            <dbReference type="PubMed" id="11316796"/>
            <dbReference type="DOI" id="10.1101/gad.876201"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 69-ARG--LEU-72</scope>
        <source>
            <strain>JJ532</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2002" name="Cell" volume="111" first="991" last="1002">
            <title>MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans.</title>
            <authorList>
                <person name="Unhavaithaya Y."/>
                <person name="Shin T.H."/>
                <person name="Miliaras N."/>
                <person name="Lee J."/>
                <person name="Oyama T."/>
                <person name="Mello C.C."/>
            </authorList>
            <dbReference type="PubMed" id="12507426"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(02)01202-3"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HDA-1; LET-418 AND MEP-1</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2003" name="Genes Dev." volume="17" first="748" last="758">
            <title>A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.</title>
            <authorList>
                <person name="Zhang F."/>
                <person name="Barboric M."/>
                <person name="Blackwell T.K."/>
                <person name="Peterlin B.M."/>
            </authorList>
            <dbReference type="PubMed" id="12651893"/>
            <dbReference type="DOI" id="10.1101/gad.1068203"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CIT-1.1</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2008" name="Genetics" volume="178" first="235" last="243">
            <title>Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation.</title>
            <authorList>
                <person name="Ghosh D."/>
                <person name="Seydoux G."/>
            </authorList>
            <dbReference type="PubMed" id="18202370"/>
            <dbReference type="DOI" id="10.1534/genetics.107.083212"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CIT-1.1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="3791" last="3801">
            <title>PIE-1 Translation in the Germline Lineage Contributes to PIE-1 Asymmetry in the Early Caenorhabditis elegans Embryo.</title>
            <authorList>
                <person name="Gauvin T.J."/>
                <person name="Han B."/>
                <person name="Sun M.J."/>
                <person name="Griffin E.E."/>
            </authorList>
            <dbReference type="PubMed" id="30279189"/>
            <dbReference type="DOI" id="10.1534/g3.118.200744"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="11">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans.</title>
            <authorList>
                <person name="Kim H."/>
                <person name="Ding Y.H."/>
                <person name="Lu S."/>
                <person name="Zuo M.Q."/>
                <person name="Tan W."/>
                <person name="Conte D. Jr."/>
                <person name="Dong M.Q."/>
                <person name="Mello C.C."/>
            </authorList>
            <dbReference type="PubMed" id="34003111"/>
            <dbReference type="DOI" id="10.7554/elife.63300"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUMOYLATION AT LYS-68</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF LYS-68</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94131-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q94131-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_044040"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255167.1">
        <property type="nucleotide sequence ID" value="NM_001268238.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y49E10.14b">
        <property type="protein sequence ID" value="CE45773"/>
        <property type="gene ID" value="WBGene00004027"/>
        <property type="gene designation" value="pie-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="Y49E10.14a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y49E10.14b"/>
        </source>
    </evidence>
    <sequence length="124" mass="13908" checksum="B5F042393DB2987D" modified="1997-02-01" version="1">MQHFNANATVYAPPSSDCPPPIAYYHHHPQHQQQFLPFPMPYFLAPPPQAQQGAPFPVQYIPQQHDLMNSQPMYAPMAPTYYYQPINSNGMPMMDVTIDPNATGGAFEVFPDGFFSQPPPTIIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-01-27" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q95NU5-2</accession>
    <name>TORS_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Torsin-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Abnormal oocyte formation protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ooc-5</name>
        <name type="ORF">C18E9.11</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="book" date="2001" name="Proceedings of the 13th international C. elegans meeting" first="159" last="159" publisher="Los Angeles">
            <title>OOC-5, required for polarity in the 2-cell embryo, encodes a AAA+ ATPase related to the human disease protein Torsin A.</title>
            <authorList>
                <person name="Basham S.E."/>
                <person name="Rose L.S."/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-125</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95NU5-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95NU5-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_001107"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_495917.1">
        <property type="nucleotide sequence ID" value="NM_063516.6"/>
    </dbReference>
    <dbReference type="WormBase" id="C18E9.11a">
        <property type="protein sequence ID" value="CE28283"/>
        <property type="gene ID" value="WBGene00003870"/>
        <property type="gene designation" value="ooc-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="350" mass="40185" checksum="19813FF9670CAB4A" modified="2001-12-01" version="1" precursor="true">MKLDYVLLLLFHLCFVNTELISVITGTTIAISAGAFWGLKDRLKCYLYECCHEPDVNFNYHTLDADIANLLFGQHLVKDVVVNSIKSHWYNENPRKPLVLSFHGYTGSGKNYVAEIIANNTFRLGLRSTFVQHIVATNDFPDKNKLEEYQVELRNRILTTVQKCQRSIFIFDEADKLPEQLLGAIKPFLDYYSTISGVDFRRSIFILLSNKGGGEIARITKEQYESGYPREQLRLEAFERELMNFSYNEKGGLQMSELISNHLIDHFVPFLPLQREHVRSCVGAYLRKRGRGDLVSNVDFVERVLNSLQYFPESSKAFSSSGCKRVDAKTDLEMAKIRPLLSSVHFDDEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q9GYH7-2</accession>
    <name>GAPD1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of GTPase-activating protein and VPS9 domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Receptor-mediated endocytosis protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rme-6</name>
        <name evidence="2" type="ORF">F49E7.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nat. Cell Biol." volume="7" first="559" last="569">
            <title>Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit.</title>
            <authorList>
                <person name="Sato M."/>
                <person name="Sato K."/>
                <person name="Fonarev P."/>
                <person name="Huang C.-J."/>
                <person name="Liou W."/>
                <person name="Grant B.D."/>
            </authorList>
            <dbReference type="PubMed" id="15895077"/>
            <dbReference type="DOI" id="10.1038/ncb1261"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH RAB5 AND ALPHA-ADAPTIN</scope>
        <scope>MUTAGENESIS OF VAL-65; CYS-1017 AND TRP-1079</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9GYH7-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_032369"/>
        </isoform>
        <isoform>
            <id>Q9GYH7-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379623.1">
        <property type="nucleotide sequence ID" value="NM_001392724.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F49E7.1b">
        <property type="protein sequence ID" value="CE26468"/>
        <property type="gene ID" value="WBGene00004377"/>
        <property type="gene designation" value="rme-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F49E7.1a"/>
        </source>
    </evidence>
    <sequence length="94" mass="10445" checksum="564E9CAFF7C80900" modified="2005-07-19" version="2">MLDIYVTAQDKLNCVVRCCDVINNLVALSSKNAVASADDLTPVLVFVIIKANPRALLSNVQFVETFAGDRIESGRDAYYWVNFKSAVEYIKTIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2026-01-28" version="167" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XWD6-2</accession>
    <name>CED1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Cell death abnormality protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">ced-1</name>
        <name evidence="6" type="ORF">Y47H9C.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1983" name="Science" volume="220" first="1277" last="1279">
            <title>Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hedgecock E.M."/>
                <person name="Sulston J.E."/>
                <person name="Thomson J.N."/>
            </authorList>
            <dbReference type="PubMed" id="6857247"/>
            <dbReference type="DOI" id="10.1126/science.6857247"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="1991" name="Genetics" volume="129" first="79" last="94">
            <title>Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ellis R.E."/>
                <person name="Jacobson D.M."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="1936965"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="4">
        <citation type="journal article" date="2001" name="Cell" volume="104" first="43" last="56">
            <title>CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans.</title>
            <authorList>
                <person name="Zhou Z."/>
                <person name="Hartwieg E."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="11163239"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(01)00190-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>IDENTIFICATION OF NPXY AND YXXL MOTIFS</scope>
        <scope>PHOSPHORYLATION AT TYR-1019</scope>
        <scope>MUTAGENESIS OF PRO-124; CYS-136; CYS-330; CYS-448; CYS-501; CYS-803; ASN-962; TYR-965 AND TYR-1019</scope>
        <source>
            <tissue evidence="1">Embryo</tissue>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2002" name="J. Biol. Chem." volume="277" first="11772" last="11779">
            <title>Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).</title>
            <authorList>
                <person name="Su H.P."/>
                <person name="Nakada-Tsukui K."/>
                <person name="Tosello-Trampont A.-C."/>
                <person name="Li Y."/>
                <person name="Bu G."/>
                <person name="Henson P.M."/>
                <person name="Ravichandran K.S."/>
            </authorList>
            <dbReference type="PubMed" id="11729193"/>
            <dbReference type="DOI" id="10.1074/jbc.M109336200"/>
        </citation>
        <scope>INTERACTION WITH CED-6</scope>
    </reference>
    <reference evidence="3" key="6">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="667" last="672">
            <title>Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Saito H."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Hirabayashi J."/>
                <person name="Kasai K."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="12754521"/>
            <dbReference type="DOI" id="10.1038/nbt829"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-333</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2003" name="Nature" volume="424" first="1066" last="1071">
            <title>Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Bloss T.A."/>
                <person name="Witze E.S."/>
                <person name="Rothman J.H."/>
            </authorList>
            <dbReference type="PubMed" id="12944970"/>
            <dbReference type="DOI" id="10.1038/nature01920"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 375-GLN--THR-1111</scope>
    </reference>
    <reference evidence="3" key="8">
        <citation type="journal article" date="2005" name="Nature" volume="434" first="93" last="99">
            <title>Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.</title>
            <authorList>
                <person name="Kinchen J.M."/>
                <person name="Cabello J."/>
                <person name="Klingele D."/>
                <person name="Wong K."/>
                <person name="Feichtinger R."/>
                <person name="Schnabel H."/>
                <person name="Schnabel R."/>
                <person name="Hengartner M.O."/>
            </authorList>
            <dbReference type="PubMed" id="15744306"/>
            <dbReference type="DOI" id="10.1038/nature03263"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="3" key="9">
        <citation type="journal article" date="2006" name="Dev. Cell" volume="10" first="743" last="757">
            <title>C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells.</title>
            <authorList>
                <person name="Yu X."/>
                <person name="Odera S."/>
                <person name="Chuang C.H."/>
                <person name="Lu N."/>
                <person name="Zhou Z."/>
            </authorList>
            <dbReference type="PubMed" id="16740477"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2006.04.007"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="10">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-66 AND ASN-333</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="11">
        <citation type="journal article" date="2008" name="Dev. Cell" volume="15" first="87" last="97">
            <title>Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.</title>
            <authorList>
                <person name="Haskins K.A."/>
                <person name="Russell J.F."/>
                <person name="Gaddis N."/>
                <person name="Dressman H.K."/>
                <person name="Aballay A."/>
            </authorList>
            <dbReference type="PubMed" id="18606143"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2008.05.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="12">
        <citation type="journal article" date="2008" name="PLoS Biol." volume="6" first="E61" last="E61">
            <title>Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells.</title>
            <authorList>
                <person name="Yu X."/>
                <person name="Lu N."/>
                <person name="Zhou Z."/>
            </authorList>
            <dbReference type="PubMed" id="18351800"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.0060061"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2016" name="J. Cell Sci." volume="129" first="341" last="353">
            <title>Loss of PGL-1 and PGL-3, members of a family of constitutive germ-granule components, promotes germline apoptosis in C. elegans.</title>
            <authorList>
                <person name="Min H."/>
                <person name="Shim Y.H."/>
                <person name="Kawasaki I."/>
            </authorList>
            <dbReference type="PubMed" id="26598553"/>
            <dbReference type="DOI" id="10.1242/jcs.174201"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="33884" last="33884">
            <title>Somatically expressed germ-granule components, PGL-1 and PGL-3, repress programmed cell death in C. elegans.</title>
            <authorList>
                <person name="Al-Amin M."/>
                <person name="Min H."/>
                <person name="Shim Y.H."/>
                <person name="Kawasaki I."/>
            </authorList>
            <dbReference type="PubMed" id="27650246"/>
            <dbReference type="DOI" id="10.1038/srep33884"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2022" name="Elife" volume="11" first="0" last="0">
            <title>trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans.</title>
            <authorList>
                <person name="Yuan L."/>
                <person name="Li P."/>
                <person name="Jing H."/>
                <person name="Zheng Q."/>
                <person name="Xiao H."/>
            </authorList>
            <dbReference type="PubMed" id="35929733"/>
            <dbReference type="DOI" id="10.7554/elife.76436"/>
        </citation>
        <scope>INTERACTION WITH CED-6; NCK-1 AND VHA-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>UBIQUITINATION</scope>
        <scope>PHOSPHORYLATION AT TYR-1019</scope>
        <scope>MUTAGENESIS OF ASN-962; TYR-965 AND TYR-1019</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9XWD6-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9XWD6-4</id>
            <name evidence="9">d</name>
            <sequence type="described" ref="VSP_053133 VSP_053134"/>
        </isoform>
        <isoform>
            <id>Q9XWD6-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_053135 VSP_053137"/>
        </isoform>
        <isoform>
            <id>Q9XWD6-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_053136"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021772.1">
        <property type="nucleotide sequence ID" value="NM_001026601.7"/>
    </dbReference>
    <dbReference type="WormBase" id="Y47H9C.4b">
        <property type="protein sequence ID" value="CE30361"/>
        <property type="gene ID" value="WBGene00000415"/>
        <property type="gene designation" value="ced-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="11163239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="11163239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAG60061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="CAA21739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y47H9C.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y47H9C.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y47H9C.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="Y47H9C.4d"/>
        </source>
    </evidence>
    <sequence length="1070" mass="114181" checksum="75254D0DD5643AE5" modified="1999-11-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2026-01-28" version="167" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XWD6-3</accession>
    <name>CED1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform c of Cell death abnormality protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">ced-1</name>
        <name evidence="6" type="ORF">Y47H9C.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1983" name="Science" volume="220" first="1277" last="1279">
            <title>Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hedgecock E.M."/>
                <person name="Sulston J.E."/>
                <person name="Thomson J.N."/>
            </authorList>
            <dbReference type="PubMed" id="6857247"/>
            <dbReference type="DOI" id="10.1126/science.6857247"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="1991" name="Genetics" volume="129" first="79" last="94">
            <title>Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ellis R.E."/>
                <person name="Jacobson D.M."/>
                <person name="Horvitz H.R."/>
            </authorList>
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        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="4">
        <citation type="journal article" date="2001" name="Cell" volume="104" first="43" last="56">
            <title>CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans.</title>
            <authorList>
                <person name="Zhou Z."/>
                <person name="Hartwieg E."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="11163239"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(01)00190-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>IDENTIFICATION OF NPXY AND YXXL MOTIFS</scope>
        <scope>PHOSPHORYLATION AT TYR-1019</scope>
        <scope>MUTAGENESIS OF PRO-124; CYS-136; CYS-330; CYS-448; CYS-501; CYS-803; ASN-962; TYR-965 AND TYR-1019</scope>
        <source>
            <tissue evidence="1">Embryo</tissue>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2002" name="J. Biol. Chem." volume="277" first="11772" last="11779">
            <title>Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).</title>
            <authorList>
                <person name="Su H.P."/>
                <person name="Nakada-Tsukui K."/>
                <person name="Tosello-Trampont A.-C."/>
                <person name="Li Y."/>
                <person name="Bu G."/>
                <person name="Henson P.M."/>
                <person name="Ravichandran K.S."/>
            </authorList>
            <dbReference type="PubMed" id="11729193"/>
            <dbReference type="DOI" id="10.1074/jbc.M109336200"/>
        </citation>
        <scope>INTERACTION WITH CED-6</scope>
    </reference>
    <reference evidence="3" key="6">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="667" last="672">
            <title>Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Saito H."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Hirabayashi J."/>
                <person name="Kasai K."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="12754521"/>
            <dbReference type="DOI" id="10.1038/nbt829"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-333</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2003" name="Nature" volume="424" first="1066" last="1071">
            <title>Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Bloss T.A."/>
                <person name="Witze E.S."/>
                <person name="Rothman J.H."/>
            </authorList>
            <dbReference type="PubMed" id="12944970"/>
            <dbReference type="DOI" id="10.1038/nature01920"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 375-GLN--THR-1111</scope>
    </reference>
    <reference evidence="3" key="8">
        <citation type="journal article" date="2005" name="Nature" volume="434" first="93" last="99">
            <title>Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.</title>
            <authorList>
                <person name="Kinchen J.M."/>
                <person name="Cabello J."/>
                <person name="Klingele D."/>
                <person name="Wong K."/>
                <person name="Feichtinger R."/>
                <person name="Schnabel H."/>
                <person name="Schnabel R."/>
                <person name="Hengartner M.O."/>
            </authorList>
            <dbReference type="PubMed" id="15744306"/>
            <dbReference type="DOI" id="10.1038/nature03263"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="3" key="9">
        <citation type="journal article" date="2006" name="Dev. Cell" volume="10" first="743" last="757">
            <title>C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells.</title>
            <authorList>
                <person name="Yu X."/>
                <person name="Odera S."/>
                <person name="Chuang C.H."/>
                <person name="Lu N."/>
                <person name="Zhou Z."/>
            </authorList>
            <dbReference type="PubMed" id="16740477"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2006.04.007"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="10">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-66 AND ASN-333</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="11">
        <citation type="journal article" date="2008" name="Dev. Cell" volume="15" first="87" last="97">
            <title>Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.</title>
            <authorList>
                <person name="Haskins K.A."/>
                <person name="Russell J.F."/>
                <person name="Gaddis N."/>
                <person name="Dressman H.K."/>
                <person name="Aballay A."/>
            </authorList>
            <dbReference type="PubMed" id="18606143"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2008.05.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="12">
        <citation type="journal article" date="2008" name="PLoS Biol." volume="6" first="E61" last="E61">
            <title>Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells.</title>
            <authorList>
                <person name="Yu X."/>
                <person name="Lu N."/>
                <person name="Zhou Z."/>
            </authorList>
            <dbReference type="PubMed" id="18351800"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.0060061"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2016" name="J. Cell Sci." volume="129" first="341" last="353">
            <title>Loss of PGL-1 and PGL-3, members of a family of constitutive germ-granule components, promotes germline apoptosis in C. elegans.</title>
            <authorList>
                <person name="Min H."/>
                <person name="Shim Y.H."/>
                <person name="Kawasaki I."/>
            </authorList>
            <dbReference type="PubMed" id="26598553"/>
            <dbReference type="DOI" id="10.1242/jcs.174201"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="33884" last="33884">
            <title>Somatically expressed germ-granule components, PGL-1 and PGL-3, repress programmed cell death in C. elegans.</title>
            <authorList>
                <person name="Al-Amin M."/>
                <person name="Min H."/>
                <person name="Shim Y.H."/>
                <person name="Kawasaki I."/>
            </authorList>
            <dbReference type="PubMed" id="27650246"/>
            <dbReference type="DOI" id="10.1038/srep33884"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2022" name="Elife" volume="11" first="0" last="0">
            <title>trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans.</title>
            <authorList>
                <person name="Yuan L."/>
                <person name="Li P."/>
                <person name="Jing H."/>
                <person name="Zheng Q."/>
                <person name="Xiao H."/>
            </authorList>
            <dbReference type="PubMed" id="35929733"/>
            <dbReference type="DOI" id="10.7554/elife.76436"/>
        </citation>
        <scope>INTERACTION WITH CED-6; NCK-1 AND VHA-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>UBIQUITINATION</scope>
        <scope>PHOSPHORYLATION AT TYR-1019</scope>
        <scope>MUTAGENESIS OF ASN-962; TYR-965 AND TYR-1019</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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            <id>Q9XWD6-2</id>
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            <dbReference type="WormBase" id="Y47H9C.4b"/>
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            <dbReference type="WormBase" id="Y47H9C.4c"/>
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            <taxon>Rhabditoidea</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="1983" name="Science" volume="220" first="1277" last="1279">
            <title>Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hedgecock E.M."/>
                <person name="Sulston J.E."/>
                <person name="Thomson J.N."/>
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            <dbReference type="PubMed" id="6857247"/>
            <dbReference type="DOI" id="10.1126/science.6857247"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="1991" name="Genetics" volume="129" first="79" last="94">
            <title>Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ellis R.E."/>
                <person name="Jacobson D.M."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="1936965"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="4">
        <citation type="journal article" date="2001" name="Cell" volume="104" first="43" last="56">
            <title>CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans.</title>
            <authorList>
                <person name="Zhou Z."/>
                <person name="Hartwieg E."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="11163239"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(01)00190-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>IDENTIFICATION OF NPXY AND YXXL MOTIFS</scope>
        <scope>PHOSPHORYLATION AT TYR-1019</scope>
        <scope>MUTAGENESIS OF PRO-124; CYS-136; CYS-330; CYS-448; CYS-501; CYS-803; ASN-962; TYR-965 AND TYR-1019</scope>
        <source>
            <tissue evidence="1">Embryo</tissue>
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    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2002" name="J. Biol. Chem." volume="277" first="11772" last="11779">
            <title>Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).</title>
            <authorList>
                <person name="Su H.P."/>
                <person name="Nakada-Tsukui K."/>
                <person name="Tosello-Trampont A.-C."/>
                <person name="Li Y."/>
                <person name="Bu G."/>
                <person name="Henson P.M."/>
                <person name="Ravichandran K.S."/>
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            <dbReference type="PubMed" id="11729193"/>
            <dbReference type="DOI" id="10.1074/jbc.M109336200"/>
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        <scope>INTERACTION WITH CED-6</scope>
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    <reference evidence="3" key="6">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="667" last="672">
            <title>Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Saito H."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Hirabayashi J."/>
                <person name="Kasai K."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
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            <dbReference type="PubMed" id="12754521"/>
            <dbReference type="DOI" id="10.1038/nbt829"/>
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        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-333</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
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    <reference key="7">
        <citation type="journal article" date="2003" name="Nature" volume="424" first="1066" last="1071">
            <title>Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Bloss T.A."/>
                <person name="Witze E.S."/>
                <person name="Rothman J.H."/>
            </authorList>
            <dbReference type="PubMed" id="12944970"/>
            <dbReference type="DOI" id="10.1038/nature01920"/>
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        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 375-GLN--THR-1111</scope>
    </reference>
    <reference evidence="3" key="8">
        <citation type="journal article" date="2005" name="Nature" volume="434" first="93" last="99">
            <title>Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.</title>
            <authorList>
                <person name="Kinchen J.M."/>
                <person name="Cabello J."/>
                <person name="Klingele D."/>
                <person name="Wong K."/>
                <person name="Feichtinger R."/>
                <person name="Schnabel H."/>
                <person name="Schnabel R."/>
                <person name="Hengartner M.O."/>
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            <dbReference type="PubMed" id="15744306"/>
            <dbReference type="DOI" id="10.1038/nature03263"/>
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        <scope>FUNCTION</scope>
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    <reference evidence="3" key="9">
        <citation type="journal article" date="2006" name="Dev. Cell" volume="10" first="743" last="757">
            <title>C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells.</title>
            <authorList>
                <person name="Yu X."/>
                <person name="Odera S."/>
                <person name="Chuang C.H."/>
                <person name="Lu N."/>
                <person name="Zhou Z."/>
            </authorList>
            <dbReference type="PubMed" id="16740477"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2006.04.007"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="10">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-66 AND ASN-333</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="11">
        <citation type="journal article" date="2008" name="Dev. Cell" volume="15" first="87" last="97">
            <title>Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.</title>
            <authorList>
                <person name="Haskins K.A."/>
                <person name="Russell J.F."/>
                <person name="Gaddis N."/>
                <person name="Dressman H.K."/>
                <person name="Aballay A."/>
            </authorList>
            <dbReference type="PubMed" id="18606143"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2008.05.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="12">
        <citation type="journal article" date="2008" name="PLoS Biol." volume="6" first="E61" last="E61">
            <title>Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells.</title>
            <authorList>
                <person name="Yu X."/>
                <person name="Lu N."/>
                <person name="Zhou Z."/>
            </authorList>
            <dbReference type="PubMed" id="18351800"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.0060061"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2016" name="J. Cell Sci." volume="129" first="341" last="353">
            <title>Loss of PGL-1 and PGL-3, members of a family of constitutive germ-granule components, promotes germline apoptosis in C. elegans.</title>
            <authorList>
                <person name="Min H."/>
                <person name="Shim Y.H."/>
                <person name="Kawasaki I."/>
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            <title>Somatically expressed germ-granule components, PGL-1 and PGL-3, repress programmed cell death in C. elegans.</title>
            <authorList>
                <person name="Al-Amin M."/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference key="15">
        <citation type="journal article" date="2022" name="Elife" volume="11" first="0" last="0">
            <title>trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans.</title>
            <authorList>
                <person name="Yuan L."/>
                <person name="Li P."/>
                <person name="Jing H."/>
                <person name="Zheng Q."/>
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            <dbReference type="DOI" id="10.7554/elife.76436"/>
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        <scope>INTERACTION WITH CED-6; NCK-1 AND VHA-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>UBIQUITINATION</scope>
        <scope>PHOSPHORYLATION AT TYR-1019</scope>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPF2</accession>
    <name>A0A078BPF2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y71F9B.6</name>
        <name evidence="2 4" type="ORF">Y71F9B.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293368.1">
        <property type="nucleotide sequence ID" value="NM_001306439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPF2"/>
    <dbReference type="GeneID" id="260184"/>
    <dbReference type="KEGG" id="cel:CELE_Y71F9B.6"/>
    <dbReference type="AGR" id="WB:WBGene00022128"/>
    <dbReference type="CTD" id="260184"/>
    <dbReference type="WormBase" id="Y71F9B.6b">
        <property type="protein sequence ID" value="CE50092"/>
        <property type="gene ID" value="WBGene00022128"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5353095at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022128">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPF2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20556">
        <property type="entry name" value="CYCLIN_CABLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012388">
        <property type="entry name" value="CABLES1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896">
        <property type="entry name" value="CDK5 AND ABL1 ENZYME SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896:SF0">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y71F9B.6b"/>
        </source>
    </evidence>
    <sequence length="451" mass="50931" checksum="DE11F1A2F2514221" modified="2014-10-29" version="1">MVKKKSNYHILVAQNFLSNISVDGSHNDTNLRIFQTKGLPKISPTEKKFSNGASSTTTIRNNESVISLGTSASLGERLSSSNLPQEYAETPQKKTSIFRRIAKIMSSDDVIYSMTATNSRSPILEEGVGREDSGLIEFRSESPSCSSNQFSFLRRLKSTITHADSSDRMRHQAHLSTEELRPFVFRDAEDQVILGQIRRKRNPSPFFTLFDKSPASISRKERRESFRNGETSEEMFAETIEVPQAVNRDSSYERGTSIDEKCDLDASRSDEPSSEVIDEYDPIAFSELGIGKRTVIRHECCVASTLHCESAERAKQVINEDFEAKYPMIHLTLSKMKSLKREMAELGVSNGIDVYTVATAYVYFEKIILKGLISKVNRKCVAGAALLVALKMNDYKKSTIKSYIEQAEDQLREPKSDLLAYELPICSVLQFRLQPTIDEIQPHVDRLQFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPF6</accession>
    <name>A0A078BPF6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mediator of RNA polymerase II transcription subunit 1.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">sop-3</name>
        <name evidence="2" type="ORF">CELE_Y71F9B.10</name>
        <name evidence="4" type="ORF">Y71F9B.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDX47422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293373.1">
        <property type="nucleotide sequence ID" value="NM_001306444.3"/>
    </dbReference>
    <dbReference type="GeneID" id="171840"/>
    <dbReference type="AGR" id="WB:WBGene00004946"/>
    <dbReference type="CTD" id="171840"/>
    <dbReference type="WormBase" id="Y71F9B.10c">
        <property type="protein sequence ID" value="CE50044"/>
        <property type="gene ID" value="WBGene00004946"/>
        <property type="gene designation" value="sop-3"/>
    </dbReference>
    <dbReference type="OMA" id="PWGDMAK"/>
    <dbReference type="OrthoDB" id="5861512at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004946">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPF6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="921"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="975"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1248"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1431"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y71F9B.10c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A078BPF6"/>
        </source>
    </evidence>
    <sequence length="1481" mass="165218" checksum="6099C10A6D046340" modified="2014-10-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPF7</accession>
    <name>A0A078BPF7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TSC22 domain family protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C30G4.4</name>
        <name evidence="3" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294805.1">
        <property type="nucleotide sequence ID" value="NM_001307876.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPF7"/>
    <dbReference type="SMR" id="A0A078BPF7"/>
    <dbReference type="PeptideAtlas" id="A0A078BPF7"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4e">
        <property type="protein sequence ID" value="CE50101"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPF7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C30G4.4e"/>
        </source>
    </evidence>
    <sequence length="335" mass="36905" checksum="A0BF74B371790FCA" modified="2014-10-29" version="1">MAALFNESLRKVNEQQPPTIIEEDETPKRANRPPDLQGFSILDEKWRSSCSDDSDDSLPVGSYISTAEKPLRFCKSVDFRPLRREAPNLTGDSCSTLPSTPVHKKNPPLPTMSSGGSRFKQSESPINMLITHREMKCDMKSEPSLKVVPVETRDPYFSPNGKHAIAKPTAAIKNIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKSVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPG4</accession>
    <name>A0A078BPG4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TSC22 domain family protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C30G4.4</name>
        <name evidence="2" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294810.1">
        <property type="nucleotide sequence ID" value="NM_001307881.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPG4"/>
    <dbReference type="SMR" id="A0A078BPG4"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4j">
        <property type="protein sequence ID" value="CE50108"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPG4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDX47448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C30G4.4j"/>
        </source>
    </evidence>
    <sequence length="207" mass="22502" checksum="2566ED1F43749C6B" modified="2014-10-29" version="1">MSSGGSRFKVVPVETRDPYFSPNGKHAIAKPTAAIKNIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKRAPLVRAKTVVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPG5</accession>
    <name>A0A078BPG5_CAEEL</name>
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        <submittedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">ceh-37</name>
        <name evidence="11" type="ORF">C37E2.5</name>
        <name evidence="9" type="ORF">CELE_C37E2.5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294799.1">
        <property type="nucleotide sequence ID" value="NM_001307870.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPG5"/>
    <dbReference type="SMR" id="A0A078BPG5"/>
    <dbReference type="GeneID" id="181530"/>
    <dbReference type="AGR" id="WB:WBGene00000458"/>
    <dbReference type="CTD" id="181530"/>
    <dbReference type="WormBase" id="C37E2.5b">
        <property type="protein sequence ID" value="CE50091"/>
        <property type="gene ID" value="WBGene00000458"/>
        <property type="gene designation" value="ceh-37"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000458">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPG5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF27">
        <property type="entry name" value="HOMEOBOX PROTEIN CEH-37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDX47432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C37E2.5b"/>
        </source>
    </evidence>
    <sequence length="251" mass="28133" checksum="1B9B9709FE43BA49" modified="2014-10-29" version="1">MNLYYEKSMIPRKNRRERTTYSRQQLEILETLFNETQYPDVFARERVADQIRLQESRIQVWFKNRRAKYRLQEKQKPKRSNEKSQEHKSEDQQQTDVLDGEPLKGGSPGYQPQIKSELESCDGAVASGKLGTPKSISPVETTASTTSSNTSAAELQWNGDHKILGFGKNETTTSAAVSPTADNASTPSSSSSITATSSLPTTSSSLSVYNYPAIYPQWGLDYSTYANPQYAQFSHNPYAGTPFWYSNGNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPG8</accession>
    <name>A0A078BPG8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TSC22 domain family protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C30G4.4</name>
        <name evidence="3" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294815.1">
        <property type="nucleotide sequence ID" value="NM_001307886.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPG8"/>
    <dbReference type="SMR" id="A0A078BPG8"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4o">
        <property type="protein sequence ID" value="CE50000"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPG8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C30G4.4o"/>
        </source>
    </evidence>
    <sequence length="237" mass="26000" checksum="3CB2A6F78B99C0A1" modified="2014-10-29" version="1">MSSGGSRFKQSESPINMLITHREMKCDMKSEPSLKVVPVETRDPYFSPNGKHAIAKPTAAIKKEEIVNRSSRSLSDIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKSVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A078BPH7</accession>
    <name>A0A078BPH7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TSC22 domain family protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C30G4.4</name>
        <name evidence="3" type="ORF">CELE_C30G4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDX47442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294804.1">
        <property type="nucleotide sequence ID" value="NM_001307875.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A078BPH7"/>
    <dbReference type="SMR" id="A0A078BPH7"/>
    <dbReference type="GeneID" id="181746"/>
    <dbReference type="AGR" id="WB:WBGene00016269"/>
    <dbReference type="CTD" id="181746"/>
    <dbReference type="WormBase" id="C30G4.4d">
        <property type="protein sequence ID" value="CE50082"/>
        <property type="gene ID" value="WBGene00016269"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016269">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A078BPH7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348:SF27">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDX47442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C30G4.4d"/>
        </source>
    </evidence>
    <sequence length="331" mass="36383" checksum="44FAB8032600F3D5" modified="2014-10-29" version="1">MAALFNESLRKVNEQQPPTIIEEDETPKRANRPPDLQGFSILDEKWRSSCSDDSDDSLPVGSYISTAEKPLRFCKSVDFRPLRREAPNLTGDSCSTLPSTPVHKKNPPLPTMSSGGSRFKVVPVETRDPYFSPNGKHAIAKPTAAIKKEEIVNRSSRSLSDIHPSSSPSVVQPTSGIPVQQRPASHLIAPNPKPVYTVPKVAPTAQVKASTIIQPTVNGQVKVSSETQISTGVMVAEANQSRRTKRAPLVRAKTVVAASPPAHNVLNIDNKIEQAMDLVKTHLMFAVREEVDGLRGKIFDLENHVRRLEAENSILKRTIPNDTLKQLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H3Y9</accession>
    <name>A0A168H3Y9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 17 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C49G7.12</name>
        <name evidence="1" type="ORF">CELE_C49G7.12</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317799.1">
        <property type="nucleotide sequence ID" value="NM_001330825.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H3Y9"/>
    <dbReference type="GeneID" id="6418710"/>
    <dbReference type="AGR" id="WB:WBGene00077593"/>
    <dbReference type="CTD" id="6418710"/>
    <dbReference type="WormBase" id="C49G7.12b">
        <property type="protein sequence ID" value="CE51612"/>
        <property type="gene ID" value="WBGene00077593"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5779082at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00077593">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A168H3Y9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SAP35556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C49G7.12b"/>
        </source>
    </evidence>
    <sequence length="247" mass="29839" checksum="705E9031CEE08943" modified="2016-07-06" version="1">MKTYHLSSEAFHKKISQQDLTPFVKYSLNKKRRWETKCDLETISQLEEAYCNMDVLVFDRVLLYYDPFWYLFYHTFYYHDFLLKFPIRQFYHKHSNKNYQYTSGNSTFGQSYKSLLPESRSPRIPEASKKLESGLSPKVAYHIITPPKNYEKLRNNDFNPVSSFRKGHRVISHWRRTDEMLDIWFALRYEELEDLDEKLIEEHDDGNYSFHSKFYNLEDHYVDKPKLSKRCRSNSNSSWSIVSETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H4D4</accession>
    <name>A0A168H4D4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">M-phase phosphoprotein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F13A2.5</name>
        <name evidence="1 3" type="ORF">F13A2.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317804.1">
        <property type="nucleotide sequence ID" value="NM_001330865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H4D4"/>
    <dbReference type="SMR" id="A0A168H4D4"/>
    <dbReference type="GeneID" id="184396"/>
    <dbReference type="KEGG" id="cel:CELE_F13A2.5"/>
    <dbReference type="AGR" id="WB:WBGene00017414"/>
    <dbReference type="CTD" id="184396"/>
    <dbReference type="WormBase" id="F13A2.5b">
        <property type="protein sequence ID" value="CE51638"/>
        <property type="gene ID" value="WBGene00017414"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876982at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017414">
        <property type="expression patterns" value="Expressed in anatomical system and 2 other cell types or tissues"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SAP35564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F13A2.5b"/>
        </source>
    </evidence>
    <sequence length="146" mass="16860" checksum="A26379402431FAC0" modified="2016-07-06" version="1">MASNSEFTFDMRKKTSPISVCHYEDVMMTLESEMEGLDGYIASLSPEEQIWVKEDALQNEQLVKEAVPWMRKEEAQATTKYRQMLIAQKKKAINKLHGHGAVVRFNPARNAKAPVNYNEGDTEDDIQFLKEIRKKSKKPKKTLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H4I0</accession>
    <name>A0A168H4I0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">figl-1</name>
        <name evidence="8" type="ORF">CELE_F32D1.1</name>
        <name evidence="10" type="ORF">F32D1.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317805.1">
        <property type="nucleotide sequence ID" value="NM_001330855.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H4I0"/>
    <dbReference type="SMR" id="A0A168H4I0"/>
    <dbReference type="GeneID" id="178829"/>
    <dbReference type="AGR" id="WB:WBGene00017981"/>
    <dbReference type="CTD" id="178829"/>
    <dbReference type="WormBase" id="F32D1.1b">
        <property type="protein sequence ID" value="CE51584"/>
        <property type="gene ID" value="WBGene00017981"/>
        <property type="gene designation" value="figl-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017981">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A168H4I0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="5">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="7">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Spastin/Vps4 C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SAP35565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F32D1.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A168H4I0"/>
        </source>
    </evidence>
    <sequence length="231" mass="25863" checksum="A933CF7AF9585AC5" modified="2016-07-06" version="1">MIGRCVASQCKATFFNISASSLTSKWVGEGEKLVRALFSVARLKLPSVIFIDEIDSLLSSRSESEHESSRRIKTEFLVQLDGVNTAPDERLLVLGATNRPQELDEAARRRFQKRLYIALPEPESRTQIVQNLLVGTRHDITNHNLERIRELTDGYSGADMRQLCTEAAMGPIRDIGDDIETIDKDDIRAVTVMDFAEAARVVRPTVDDSQLDAYAAWDKKFGCLPPPSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSJ0</accession>
    <name>A0A1C3NSJ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">sbsp-1</name>
        <name evidence="5" type="ORF">CELE_R17.3</name>
        <name evidence="7" type="ORF">R17.3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SBV53371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317878.1">
        <property type="nucleotide sequence ID" value="NM_001330968.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSJ0"/>
    <dbReference type="GeneID" id="176513"/>
    <dbReference type="AGR" id="WB:WBGene00011269"/>
    <dbReference type="CTD" id="176513"/>
    <dbReference type="WormBase" id="R17.3c">
        <property type="protein sequence ID" value="CE51699"/>
        <property type="gene ID" value="WBGene00011269"/>
        <property type="gene designation" value="sbsp-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="98591at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011269">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSJ0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056801">
        <property type="entry name" value="SBSPON_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF5">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25031">
        <property type="entry name" value="SBSPON_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SMB" evidence="4">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SBV53371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="R17.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSJ0"/>
        </source>
    </evidence>
    <sequence length="254" mass="29158" checksum="421E822A49AECF81" modified="2016-11-02" version="1">MPLKVTSTPLLYEENRVQPANNLYYLESSISECYCDEHCVTLGDCCSDYTFVCPPRDCVLTDWDSWTQCTADNGTCGIGTQKRLRHVIQHAERGGAACEPLKEMRTCFVECRPKKSALDDITTVALILDYRHNKTRSKIRRNNIYWDLPNVAEKMKKATYYCVHYTIDWVNRNCVSRLLNKGLSEGSVMCAECQPEATYHRNNGRCASDLEDGDQGFWKLIGPQSCNGIWTRINRTENCQCQIEYPKDHPFLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSJ2</accession>
    <name>A0A1C3NSJ2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SOSS complex subunit A homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y56A3A.31</name>
        <name evidence="1 3" type="ORF">Y56A3A.31</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SBV53377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317884.1">
        <property type="nucleotide sequence ID" value="NM_001330972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSJ2"/>
    <dbReference type="GeneID" id="190330"/>
    <dbReference type="KEGG" id="cel:CELE_Y56A3A.31"/>
    <dbReference type="AGR" id="WB:WBGene00013243"/>
    <dbReference type="CTD" id="190330"/>
    <dbReference type="WormBase" id="Y56A3A.31c">
        <property type="protein sequence ID" value="CE51724"/>
        <property type="gene ID" value="WBGene00013243"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5861309at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013243">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSJ2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027844">
        <property type="entry name" value="INTS15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14540">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14540:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14964">
        <property type="entry name" value="INTS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SBV53377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y56A3A.31c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSJ2"/>
        </source>
    </evidence>
    <sequence length="340" mass="39487" checksum="0278C8EE921CE663" modified="2016-11-02" version="1">MSRSRGSALAEKPEVQAMLDKDLFLIQSDRRTKMNAMQQLQLVRVLAQFFLERVDDGHRYSYFEAIFLGRSDDPTLHEYRLSVMFQLVSFSIQYPVLQILNHVMGWLCQMKNVEQERIYSDRLIDMIIEHFVRLSNEQNRMHEYLIPLEGTCSEFCALFVSRATLHGPLSPPMITLIVRYCTRNMQFILRHLRDTSWLGNDFAEKVVPKLVEQTLLDDDSDSLGSCLCYVLFRWHIDVLANEDRKGPTKRIEVLDLLLSADYPWTKRRACVLASAIGASTRPEAEIQKELQRLEVPEHFQPVIDLLCSKGIKKSSQTVLDAISEMHLVEEMDRMITEDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSJ3</accession>
    <name>A0A1C3NSJ3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">unc-13</name>
        <name evidence="11" type="ORF">CELE_ZK524.2</name>
        <name evidence="13" type="ORF">ZK524.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SBV53357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317867.1">
        <property type="nucleotide sequence ID" value="NM_001330931.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1C3NSJ3"/>
    <dbReference type="GeneID" id="172497"/>
    <dbReference type="AGR" id="WB:WBGene00006752"/>
    <dbReference type="CTD" id="43841"/>
    <dbReference type="WormBase" id="ZK524.2g">
        <property type="protein sequence ID" value="CE33016"/>
        <property type="gene ID" value="WBGene00006752"/>
        <property type="gene designation" value="unc-13"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10053234at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006752">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSJ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04027">
        <property type="entry name" value="C2B_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08395">
        <property type="entry name" value="C2C_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000002">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000037">
        <property type="entry name" value="RAS guanyl releasing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037302">
        <property type="entry name" value="Unc-13_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_DAG_PE_1"/>
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        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="344"/>
            <end position="394"/>
        </location>
    </feature>
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        <location>
            <begin position="450"/>
            <end position="578"/>
        </location>
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        <location>
            <begin position="862"/>
            <end position="1005"/>
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        <location>
            <begin position="1108"/>
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            <begin position="1279"/>
            <end position="1407"/>
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            <begin position="1"/>
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        <location>
            <begin position="125"/>
            <end position="152"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SBV53357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="ZK524.2g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSJ3"/>
        </source>
    </evidence>
    <sequence length="1465" mass="166382" checksum="AE14A54637032299" modified="2016-11-02" version="1"> </sequence>
</entry>
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    <accession>A0A1C3NSJ8</accession>
    <name>A0A1C3NSJ8_CAEEL</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="12 14" type="primary">sms-3</name>
        <name evidence="12" type="ORF">CELE_Y22D7AL.8</name>
        <name evidence="14" type="ORF">Y22D7AL.8</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
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    </dbReference>
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        <property type="protein sequence ID" value="CE51755"/>
        <property type="gene ID" value="WBGene00004894"/>
        <property type="gene designation" value="sms-3"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
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    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="92"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
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        <location>
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            <end position="281"/>
        </location>
    </feature>
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        <location>
            <begin position="328"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SBV53374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="Y22D7AL.8d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSJ8"/>
        </source>
    </evidence>
    <sequence length="374" mass="42252" checksum="94F56B50286FE0BF" modified="2016-11-02" version="1">MVKTVEFREIVPKNFEYSPETDDSYCGDEEQRRSMGSVSKTVISARGASPDDEQNGTKNGISNGSEWAKCIFLFFFLFIAGMSNWAVLAYTHDYVPRESLPDIVFSLVSEQRWASSLGDFCVALCIVMLGALLVIHQHRGTILKRVVFCAGTLYAMRSVTLAATQLPSGYTDNQGRCRDQVESEAGVFFGRLFEQTIRIGFQSKDQMLCGDLLFSGHTLVMVTCSLAVAYYLPKSIKPLQWVSHVACLIGMICMTISRTHYTIDVVIAYWLSNMVFRMYHAYCEVDMCMERRKSILYSWWPCRIVDWLEQDIVPGRLENRCQLPWRRSTPRGQERGGASAESSDSSVTMCDNITTSHHQKHVSISSSSTYPLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSJ9</accession>
    <name>A0A1C3NSJ9_CAEEL</name>
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        <submittedName>
            <fullName evidence="12">Sphingomyelin synthase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="12 14" type="primary">sms-3</name>
        <name evidence="12" type="ORF">CELE_Y22D7AL.8</name>
        <name evidence="14" type="ORF">Y22D7AL.8</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SBV53375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317882.1">
        <property type="nucleotide sequence ID" value="NM_001330980.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSJ9"/>
    <dbReference type="SMR" id="A0A1C3NSJ9"/>
    <dbReference type="GeneID" id="175313"/>
    <dbReference type="AGR" id="WB:WBGene00004894"/>
    <dbReference type="CTD" id="175313"/>
    <dbReference type="WormBase" id="Y22D7AL.8e">
        <property type="protein sequence ID" value="CE51713"/>
        <property type="gene ID" value="WBGene00004894"/>
        <property type="gene designation" value="sms-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004894">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSJ9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF34">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="11">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SBV53375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="Y22D7AL.8e"/>
        </source>
    </evidence>
    <sequence length="168" mass="19245" checksum="69B897972A8B4FD3" modified="2016-11-02" version="1">MLCGDLLFSGHTLVMVTCSLAVAYYLPKSIKPLQWVSHVACLIGMICMTISRTHYTIDVVIAYWLSNMVFRMYHAYCEVDMCMERRKSILYSWWPCRIVDWLEQDIVPGRLENRCQLPWRRSTPRGQERGGASAESSDSSVTMCDNITTSHHQKHVSISSSSTYPLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSK5</accession>
    <name>A0A1C3NSK5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sphingomyelin synthase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">sms-3</name>
        <name evidence="12" type="ORF">CELE_Y22D7AL.8</name>
        <name evidence="14" type="ORF">Y22D7AL.8</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SBV53373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317880.1">
        <property type="nucleotide sequence ID" value="NM_001330978.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSK5"/>
    <dbReference type="SMR" id="A0A1C3NSK5"/>
    <dbReference type="GeneID" id="175313"/>
    <dbReference type="AGR" id="WB:WBGene00004894"/>
    <dbReference type="CTD" id="175313"/>
    <dbReference type="WormBase" id="Y22D7AL.8c">
        <property type="protein sequence ID" value="CE51745"/>
        <property type="gene ID" value="WBGene00004894"/>
        <property type="gene designation" value="sms-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004894">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSK5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF34">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="11">
        <location>
            <begin position="195"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SBV53373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="Y22D7AL.8c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSK5"/>
        </source>
    </evidence>
    <sequence length="360" mass="40460" checksum="2F5917E63EA465BD" modified="2016-11-02" version="1">MADTITTDDSYCGDEEQRRSMGSVSKTVISARGASPDDEQNGTKNGISNGSEWAKCIFLFFFLFIAGMSNWAVLAYTHDYVPRESLPDIVFSLVSEQRWASSLGDFCVALCIVMLGALLVIHQHRGTILKRVVFCAGTLYAMRSVTLAATQLPSGYTDNQGRCRDQVESEAGVFFGRLFEQTIRIGFQSKDQMLCGDLLFSGHTLVMVTCSLAVAYYLPKSIKPLQWVSHVACLIGMICMTISRTHYTIDVVIAYWLSNMVFRMYHAYCEVDMCMERRKSILYSWWPCRIVDWLEQDIVPGRLENRCQLPWRRSTPRGQERGGASAESSDSSVTMCDNITTSHHQKHVSISSSSTYPLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSK7</accession>
    <name>A0A1C3NSK7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">mig-39</name>
        <name evidence="8" type="ORF">CELE_F42H10.5</name>
        <name evidence="10" type="ORF">F42H10.5</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SBV53369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317876.1">
        <property type="nucleotide sequence ID" value="NM_001330939.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSK7"/>
    <dbReference type="GeneID" id="185686"/>
    <dbReference type="AGR" id="WB:WBGene00018369"/>
    <dbReference type="CTD" id="185686"/>
    <dbReference type="WormBase" id="F42H10.5b">
        <property type="protein sequence ID" value="CE51710"/>
        <property type="gene ID" value="WBGene00018369"/>
        <property type="gene designation" value="mig-39"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839926at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018369">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSK7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="773"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SBV53369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F42H10.5b"/>
        </source>
    </evidence>
    <sequence length="851" mass="93518" checksum="D48A04F994CED32B" modified="2016-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSK8</accession>
    <name>A0A1C3NSK8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IRS-type PTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">ist-1</name>
        <name evidence="4" type="ORF">C54D1.3</name>
        <name evidence="2" type="ORF">CELE_C54D1.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="SBV53385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317892.1">
        <property type="nucleotide sequence ID" value="NM_001330903.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSK8"/>
    <dbReference type="SMR" id="A0A1C3NSK8"/>
    <dbReference type="STRING" id="6239.C54D1.3b.1"/>
    <dbReference type="PaxDb" id="6239-C54D1.3"/>
    <dbReference type="GeneID" id="180978"/>
    <dbReference type="KEGG" id="cel:CELE_C54D1.3"/>
    <dbReference type="AGR" id="WB:WBGene00002163"/>
    <dbReference type="CTD" id="180978"/>
    <dbReference type="WormBase" id="C54D1.3b">
        <property type="protein sequence ID" value="CE51697"/>
        <property type="gene ID" value="WBGene00002163"/>
        <property type="gene designation" value="ist-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUNU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="946068at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002163">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSK8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48232">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48232:SF1">
        <property type="entry name" value="IRS-TYPE PTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SBV53385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C54D1.3b"/>
        </source>
    </evidence>
    <sequence length="1093" mass="123782" checksum="7657E83394051A26" modified="2016-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSL0</accession>
    <name>A0A1C3NSL0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sphingomyelin synthase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">sms-3</name>
        <name evidence="12" type="ORF">CELE_Y22D7AL.8</name>
        <name evidence="14" type="ORF">Y22D7AL.8</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SBV53372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317879.1">
        <property type="nucleotide sequence ID" value="NM_001330977.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSL0"/>
    <dbReference type="SMR" id="A0A1C3NSL0"/>
    <dbReference type="GeneID" id="175313"/>
    <dbReference type="KEGG" id="cel:CELE_Y22D7AL.8"/>
    <dbReference type="AGR" id="WB:WBGene00004894"/>
    <dbReference type="CTD" id="175313"/>
    <dbReference type="WormBase" id="Y22D7AL.8b">
        <property type="protein sequence ID" value="CE51698"/>
        <property type="gene ID" value="WBGene00004894"/>
        <property type="gene designation" value="sms-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004894">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSL0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF34">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="11">
        <location>
            <begin position="260"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SBV53372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="Y22D7AL.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSL0"/>
        </source>
    </evidence>
    <sequence length="425" mass="47650" checksum="F27AAC27A3455194" modified="2016-11-02" version="1">MIEYPITHATTSKTHHHHYSPSLATSLSSDKSATSSTYRLNRVESEEEFDERPGAESATSNTVLLMADTITTDDSYCGDEEQRRSMGSVSKTVISARGASPDDEQNGTKNGISNGSEWAKCIFLFFFLFIAGMSNWAVLAYTHDYVPRESLPDIVFSLVSEQRWASSLGDFCVALCIVMLGALLVIHQHRGTILKRVVFCAGTLYAMRSVTLAATQLPSGYTDNQGRCRDQVESEAGVFFGRLFEQTIRIGFQSKDQMLCGDLLFSGHTLVMVTCSLAVAYYLPKSIKPLQWVSHVACLIGMICMTISRTHYTIDVVIAYWLSNMVFRMYHAYCEVDMCMERRKSILYSWWPCRIVDWLEQDIVPGRLENRCQLPWRRSTPRGQERGGASAESSDSSVTMCDNITTSHHQKHVSISSSSTYPLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSL2</accession>
    <name>A0A1C3NSL2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">IRK_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">irk-3</name>
        <name evidence="15" type="ORF">CELE_K04G11.5</name>
        <name evidence="17" type="ORF">K04G11.5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="SBV53397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317904.1">
        <property type="nucleotide sequence ID" value="NM_001330921.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSL2"/>
    <dbReference type="SMR" id="A0A1C3NSL2"/>
    <dbReference type="GeneID" id="191696"/>
    <dbReference type="AGR" id="WB:WBGene00002151"/>
    <dbReference type="CTD" id="191696"/>
    <dbReference type="WormBase" id="K04G11.5e">
        <property type="protein sequence ID" value="CE51711"/>
        <property type="gene ID" value="WBGene00002151"/>
        <property type="gene designation" value="irk-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002151">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSL2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000007">
        <property type="entry name" value="Inward Rectifying K (Potassium) channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF61">
        <property type="entry name" value="IRK_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="14">
        <location>
            <begin position="57"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SBV53397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="K04G11.5e"/>
        </source>
    </evidence>
    <sequence length="245" mass="28329" checksum="F13F95C4E35FFFE9" modified="2016-11-02" version="1">MESQHTIGYGLRYMTDLCPPAYLTLCVQCVVGVFLQTILAGIVIAKILRPKKRRQEMRFSRMAVIGPLDEHDKRPTLMIRLADIQEKLFLAESHVRLYMACSKINSRGDRELIGVKDMNVGYDSGWDRVLLLWPIIVRHVINEDSPLYGMSRENIVKADFELIMTVEGIVEATGMTFQARTSFLPDEILWGYKFKPMVLMNEKLSKYEVHYSFFDQTERVCDFDAQTIETEETEDEHHHNASGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSL4</accession>
    <name>A0A1C3NSL4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phorbol ester/diacylglycerol-binding protein unc-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">unc-13</name>
        <name evidence="11" type="ORF">CELE_ZK524.2</name>
        <name evidence="13" type="ORF">ZK524.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SBV53356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317866.1">
        <property type="nucleotide sequence ID" value="NM_001330929.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1C3NSL4"/>
    <dbReference type="GeneID" id="172497"/>
    <dbReference type="AGR" id="WB:WBGene00006752"/>
    <dbReference type="CTD" id="43841"/>
    <dbReference type="WormBase" id="ZK524.2k">
        <property type="protein sequence ID" value="CE51726"/>
        <property type="gene ID" value="WBGene00006752"/>
        <property type="gene designation" value="unc-13"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10053234at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006752">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSL4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08394">
        <property type="entry name" value="C2A_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04027">
        <property type="entry name" value="C2B_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08395">
        <property type="entry name" value="C2C_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000002">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000031">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000037">
        <property type="entry name" value="RAS guanyl releasing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037302">
        <property type="entry name" value="Unc-13_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="677"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="783"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="9">
        <location>
            <begin position="1195"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="10">
        <location>
            <begin position="1441"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1612"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SBV53356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="ZK524.2k"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSL4"/>
        </source>
    </evidence>
    <sequence length="1798" mass="205610" checksum="92A343A6388D0092" modified="2016-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSL5</accession>
    <name>A0A1C3NSL5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Abnormal cell migration protein 18-like fibronectin type I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_ZC412.3</name>
        <name evidence="3 5" type="ORF">ZC412.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SBV53379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317886.1">
        <property type="nucleotide sequence ID" value="NM_001330883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSL5"/>
    <dbReference type="GeneID" id="3565691"/>
    <dbReference type="AGR" id="WB:WBGene00013884"/>
    <dbReference type="CTD" id="3565691"/>
    <dbReference type="WormBase" id="ZC412.3b">
        <property type="protein sequence ID" value="CE51758"/>
        <property type="gene ID" value="WBGene00013884"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5785512at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013884">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSL5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040282">
        <property type="entry name" value="Mig-18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572:SF7">
        <property type="entry name" value="PROTEIN CBG04538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572">
        <property type="entry name" value="PROTEIN CBG04538-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008679465" evidence="1">
        <location>
            <begin position="18"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="106"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="175"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="256"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="337"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="2">
        <location>
            <begin position="409"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SBV53379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="ZC412.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSL5"/>
        </source>
    </evidence>
    <sequence length="477" mass="51543" checksum="0B67B0ADF2192DF4" modified="2016-11-02" version="1">MRTLVLLSSVAILSTLAVKCKYDGKDLENNEVITVQNAFRIKCLTEDNGSWKTEIIGCVTPDGTEINAGEKKEVGDKVHECVKSESGQVSLKESKGRTAACPGGQKHGEQWQEKSFKFRCGDGGVVKFEACVGQDGSVIPAGETGKIGGFDVKCEQHANGTITMQAANDPKSYDCTAKDGSSKKNGEEYVEGNFVRKCGDYGQGKIIGCHAENVGNTIGINQNVTSGDIVYSCTKDGSNYSFKTYSLKKPEVYAMCAHEGKQYKNDTTFISQGSFRMKCVTFKNLTSTLEVISCITPAGVEISIGTQLEEGDKVFECTPGNVTLKSTPGQTGKCRGVYSVGDTWVEDSFRLLCEPYGKVNLKSCISKEGVEIPLGEARRVPAGYAMECVTVNGNVALQTAKTFDCETGTGEIKKFGDTWNEGNFVRRCANYGVSAIIGCYADGVGSIGLNQNMTSGDFLYMCINQNEQFKFRTLKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSM0</accession>
    <name>A0A1C3NSM0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C46H3.2</name>
        <name evidence="3" type="ORF">CELE_C46H3.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="SBV53394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317901.1">
        <property type="nucleotide sequence ID" value="NM_001330892.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSM0"/>
    <dbReference type="SMR" id="A0A1C3NSM0"/>
    <dbReference type="GeneID" id="3564865"/>
    <dbReference type="AGR" id="WB:WBGene00016725"/>
    <dbReference type="CTD" id="3564865"/>
    <dbReference type="WormBase" id="C46H3.2c">
        <property type="protein sequence ID" value="CE51750"/>
        <property type="gene ID" value="WBGene00016725"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5314041at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016725">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSM0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd09497">
        <property type="entry name" value="SAM_caskin1_2_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09498">
        <property type="entry name" value="SAM_caskin1_2_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000071">
        <property type="entry name" value="Caskin, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000028">
        <property type="entry name" value="caskin-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035497">
        <property type="entry name" value="Caskin1/2_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035498">
        <property type="entry name" value="Caskin1/2_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155:SF11">
        <property type="entry name" value="CASKIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155">
        <property type="entry name" value="OSTEOCLAST-STIMULATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="170"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SBV53394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C46H3.2c"/>
        </source>
    </evidence>
    <sequence length="480" mass="52364" checksum="D942009FE844B493" modified="2016-11-02" version="1">MYSSSSCLYPVKVENHYASIGSSSSQSSSGFESAKCSTSTSASSFPSGVQSNESGCESAHSVRSVESGSGSSSSIHGLDDSLYRSIHEVDVTSMVQSGVPHAEVLANWLDSINMSNYLAVFLKQGYDLQTIARCTPADLLSLGIKNPDHRKKLMSDIHSWKIIDQWPSVVPNNSLREWLHAIALAEYIPMFESQRYTSVSDVLDLQWEDFEDIGVKRLGHLKRFGLTIKKLKDHQRHASNSLHPSHYAVHSNTSSYNSSYSSPQSFGYSTPSPIQRQPASASRLNDPPPPAPSAPNRAFRASCDKIDYLSYQQNNWKSASALPEAPAFLSVKPKSTSDLLFGDDTPIRLNLVPTGKILSDISKLKKDEEEDQELDDPNECPPPPAPLHCNVGLHHISSGNLSSFNSSLSNDQFPFANENCGTIRYSSTRPATAFDIPAALPPLLSDDHASDHSSVGSCNKPTIDEMLQDIQGAMDNLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSM1</accession>
    <name>A0A1C3NSM1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">unc-9</name>
        <name evidence="12" type="synonym">inx</name>
        <name evidence="13" type="ORF">CELE_R12H7.1</name>
        <name evidence="15" type="ORF">R12H7.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="SBV53401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317908.1">
        <property type="nucleotide sequence ID" value="NM_001330917.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSM1"/>
    <dbReference type="SMR" id="A0A1C3NSM1"/>
    <dbReference type="GeneID" id="181443"/>
    <dbReference type="AGR" id="WB:WBGene00006749"/>
    <dbReference type="CTD" id="181443"/>
    <dbReference type="WormBase" id="R12H7.1b">
        <property type="protein sequence ID" value="CE51729"/>
        <property type="gene ID" value="WBGene00006749"/>
        <property type="gene designation" value="unc-9"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006749">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSM1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF30">
        <property type="entry name" value="INNEXIN UNC-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SBV53401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="R12H7.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSM1"/>
        </source>
    </evidence>
    <sequence length="322" mass="37847" checksum="ACD7F4F17FC2F394" modified="2016-11-02" version="1">MEQYTENYCWVQNTYFLPLHDYIPHNYAERENRQIGYYQWVPFVLALEALLFYVPTIVWRLLSWQSGIHVQSLVQMACDSRLLDLESRNRALQTIATNVEEALHVKHQVMSGNRLKLLNLIICTRSSGAAVTFLYISVKILYTVNIVGQIFLLNTFLGNRSKWYGLQVLNDLMNGREWEESGHFPRVTLCDFEVKVLGNVHRHTVQCVLMINMFNEKIFLFLWFWYFLLAGATLCSLFYWIYISVVPSRQLNFVGKYLTGIEGYKMVDSQSLRRFVFHFLRQDGVFLLRMVATHAGELPCYELAKTLWNNYCDNKEGKMHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSM2</accession>
    <name>A0A1C3NSM2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_D2007.2</name>
        <name evidence="2 4" type="ORF">D2007.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SBV53368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317875.1">
        <property type="nucleotide sequence ID" value="NM_001330934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSM2"/>
    <dbReference type="SMR" id="A0A1C3NSM2"/>
    <dbReference type="GeneID" id="183938"/>
    <dbReference type="AGR" id="WB:WBGene00017042"/>
    <dbReference type="CTD" id="183938"/>
    <dbReference type="WormBase" id="D2007.2d">
        <property type="protein sequence ID" value="CE51714"/>
        <property type="gene ID" value="WBGene00017042"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5854456at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017042">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSM2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF1">
        <property type="entry name" value="PROTEIN CBG16675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SBV53368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="D2007.2d"/>
        </source>
    </evidence>
    <sequence length="80" mass="9051" checksum="CA9296FC9D4BFDB2" modified="2016-11-02" version="1">MYRVTPVYATVEPGQSLPLHIARITSDLIKRDRLCVNILEADGNKEAREIFKKNANTRAPASINMALEATNDNQNHHHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSM6</accession>
    <name>A0A1C3NSM6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid synthase</fullName>
            <ecNumber evidence="2">2.3.1.85</ecNumber>
            <ecNumber evidence="1">3.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">pks-1</name>
        <name evidence="15" type="ORF">C41A3.1</name>
        <name evidence="13" type="ORF">CELE_C41A3.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.85" evidence="2"/>
    <dbReference type="EC" id="3.1.2.14" evidence="1"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="SBV53393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317900.1">
        <property type="nucleotide sequence ID" value="NM_001330898.4"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1C3NSM6"/>
    <dbReference type="GeneID" id="180815"/>
    <dbReference type="KEGG" id="cel:CELE_C41A3.1"/>
    <dbReference type="AGR" id="WB:WBGene00016558"/>
    <dbReference type="CTD" id="180815"/>
    <dbReference type="WormBase" id="C41A3.1b">
        <property type="protein sequence ID" value="CE51741"/>
        <property type="gene ID" value="WBGene00016558"/>
        <property type="gene designation" value="pks-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016558">
        <property type="expression patterns" value="Expressed in material anatomical entity and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSM6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="824"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="1468"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="1888"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2796"/>
            <end position="2874"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2948"/>
            <end position="3025"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3476"/>
            <end position="3553"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="4261"/>
            <end position="4335"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1468"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1627"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2923"/>
            <end position="2944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SBV53393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="C41A3.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSM6"/>
        </source>
    </evidence>
    <sequence length="4584" mass="510112" checksum="7FE31ABCAA571466" modified="2016-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSN2</accession>
    <name>A0A1C3NSN2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T08H10.3</name>
        <name evidence="2 4" type="ORF">T08H10.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SBV53378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSN2"/>
    <dbReference type="SMR" id="A0A1C3NSN2"/>
    <dbReference type="AGR" id="WB:WBGene00020370"/>
    <dbReference type="WormBase" id="T08H10.3b">
        <property type="protein sequence ID" value="CE51752"/>
        <property type="gene ID" value="WBGene00020370"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877342at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020370">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSN2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SBV53378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T08H10.3b"/>
        </source>
    </evidence>
    <sequence length="105" mass="11849" checksum="2AA902ACE2668E58" modified="2016-11-02" version="1">MAKVGSDEKKEDPKDDKGDTKSPVPDGGAADAKPVDQSQKPFPKFEMPTESKKKKKMAENEVDKKEKMKNGFYQEKSDEDDTLEKVASLKVEQSDKTKRSKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSN4</accession>
    <name>A0A1C3NSN4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SMB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">sbsp-1</name>
        <name evidence="6" type="ORF">CELE_R17.3</name>
        <name evidence="8" type="ORF">R17.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SBV53370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317877.1">
        <property type="nucleotide sequence ID" value="NM_001330967.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSN4"/>
    <dbReference type="GeneID" id="176513"/>
    <dbReference type="KEGG" id="cel:CELE_R17.3"/>
    <dbReference type="AGR" id="WB:WBGene00011269"/>
    <dbReference type="CTD" id="176513"/>
    <dbReference type="WormBase" id="R17.3b">
        <property type="protein sequence ID" value="CE51722"/>
        <property type="gene ID" value="WBGene00011269"/>
        <property type="gene designation" value="sbsp-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="98591at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011269">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSN4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056801">
        <property type="entry name" value="SBSPON_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF5">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25031">
        <property type="entry name" value="SBSPON_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008679460" evidence="4">
        <location>
            <begin position="20"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="5">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SBV53370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="R17.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSN4"/>
        </source>
    </evidence>
    <sequence length="429" mass="49006" checksum="180E5A5A4BF7A119" modified="2016-11-02" version="1">MRHFLFVSLVFSIPYTCHAGCYQRRLCCAGRNNTCKGVDDGIAHLPTVSTIHNEEAQTFHQRPTVRTEKEYYTPHYESSGDGYDLIFPDVFDEESDERIGKLVLPDIIEMDGSGADKVYERYGLGSGDGEPEDVETQEIPLTTPAPRLKTLIFGLKRDQRTPPEEITRYSLLSKFMPLKVTSTPLLYEENRVQPANNLYYLESSISECYCDEHCVTLGDCCSDYTFVCPPRDCVLTDWDSWTQCTADNGTCGIGTQKRLRHVIQHAERGGAACEPLKEMRTCFVECRPKKSALDDITTVALILDYRHNKTRSKIRRNNIYWDLPNVAEKMKKATYYCVHYTIDWVNRNCVSRLLNKGLSEGSVMCAECQPEATYHRNNGRCASDLEDGDQGFWKLIGPQSCNGIWTRINRTENCQCQIEYPKDHPFLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSN5</accession>
    <name>A0A1C3NSN5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phorbol ester/diacylglycerol-binding protein unc-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">unc-13</name>
        <name evidence="11" type="ORF">CELE_ZK524.2</name>
        <name evidence="13" type="ORF">ZK524.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SBV53354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317864.1">
        <property type="nucleotide sequence ID" value="NM_001330927.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1C3NSN5"/>
    <dbReference type="GeneID" id="172497"/>
    <dbReference type="AGR" id="WB:WBGene00006752"/>
    <dbReference type="CTD" id="43841"/>
    <dbReference type="WormBase" id="ZK524.2i">
        <property type="protein sequence ID" value="CE32552"/>
        <property type="gene ID" value="WBGene00006752"/>
        <property type="gene designation" value="unc-13"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10053234at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006752">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSN5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08394">
        <property type="entry name" value="C2A_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04027">
        <property type="entry name" value="C2B_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08395">
        <property type="entry name" value="C2C_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000002">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000031">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000037">
        <property type="entry name" value="RAS guanyl releasing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037302">
        <property type="entry name" value="Unc-13_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="695"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="801"/>
            <end position="929"/>
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        <source>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y72A10A.1</name>
        <name evidence="2 4" type="ORF">Y72A10A.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="SBV53388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317895.1">
        <property type="nucleotide sequence ID" value="NM_001330902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSP0"/>
    <dbReference type="GeneID" id="190620"/>
    <dbReference type="KEGG" id="cel:CELE_Y72A10A.1"/>
    <dbReference type="AGR" id="WB:WBGene00022202"/>
    <dbReference type="CTD" id="190620"/>
    <dbReference type="WormBase" id="Y72A10A.1b">
        <property type="protein sequence ID" value="CE51715"/>
        <property type="gene ID" value="WBGene00022202"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5824934at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022202">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSP0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SBV53388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y72A10A.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSP0"/>
        </source>
    </evidence>
    <sequence length="138" mass="15654" checksum="B04D8648EA9D31B8" modified="2016-11-02" version="1">MAILEKFEQRVERVCLVDKPVDYPFLPDSLFSYMANKMPKLQFIYLRELDLEKINRGTVVELANHPNLKKVIVHLCRNYEVLEDFRNLPQLLVVKGEIMGLKAMLGDFEEEIAKSTASSSAQSSEASAHSPVPVNNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSP3</accession>
    <name>A0A1C3NSP3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_D2007.2</name>
        <name evidence="4 6" type="ORF">D2007.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SBV53366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317873.1">
        <property type="nucleotide sequence ID" value="NM_001330932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSP3"/>
    <dbReference type="SMR" id="A0A1C3NSP3"/>
    <dbReference type="GeneID" id="183938"/>
    <dbReference type="KEGG" id="cel:CELE_D2007.2"/>
    <dbReference type="AGR" id="WB:WBGene00017042"/>
    <dbReference type="CTD" id="183938"/>
    <dbReference type="WormBase" id="D2007.2b">
        <property type="protein sequence ID" value="CE51735"/>
        <property type="gene ID" value="WBGene00017042"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5854456at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017042">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSP3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF1">
        <property type="entry name" value="PROTEIN CBG16675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="3">
        <location>
            <begin position="129"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SBV53366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="D2007.2b"/>
        </source>
    </evidence>
    <sequence length="248" mass="27453" checksum="3A0BC01D3CF3BCCE" modified="2016-11-02" version="1">MAEHVALEDITNCPIHNIDEDNNVFSTTTTRPSRTEHRLRMLAKNFKDIRSSSMASSSSAALRPFGTARLTPGRQTGRQTQQQISAPEPMIAIALSDMEYLMRSARSSRSSGRSERQPGCTCCCHIAAGVTVIPRVARFSIEGGLSTHTLMNHSDNRIAVKITCSDNNMYRVTPVYATVEPGQSLPLHIARITSDLIKRDRLCVNILEADGNKEAREIFKKNANTRAPASINMALEATNDNQNHHHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSP8</accession>
    <name>A0A1C3NSP8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Inward rectifier potassium channel C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">irk-3</name>
        <name evidence="13" type="ORF">CELE_K04G11.5</name>
        <name evidence="15" type="ORF">K04G11.5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="SBV53398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317905.1">
        <property type="nucleotide sequence ID" value="NM_001330922.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSP8"/>
    <dbReference type="SMR" id="A0A1C3NSP8"/>
    <dbReference type="GeneID" id="191696"/>
    <dbReference type="AGR" id="WB:WBGene00002151"/>
    <dbReference type="CTD" id="191696"/>
    <dbReference type="WormBase" id="K04G11.5f">
        <property type="protein sequence ID" value="CE51742"/>
        <property type="gene ID" value="WBGene00002151"/>
        <property type="gene designation" value="irk-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002151">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSP8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000017">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF61">
        <property type="entry name" value="IRK_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SBV53398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="K04G11.5f"/>
        </source>
    </evidence>
    <sequence length="128" mass="14956" checksum="8FF722504E9FEE46" modified="2016-11-02" version="1">MNVGYDSGWDRVLLLWPIIVRHVINEDSPLYGMSRENIVKADFELIMTVEGIVEATGMTFQARTSFLPDEILWGYKFKPMVLMNEKLSKYEVHYSFFDQTERVCDFDAQTIETEETEDEHHHNASGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3Q9</accession>
    <name>A0A2C9C3Q9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dendritic cell-specific transmembrane protein-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">spe-49</name>
        <name evidence="7" type="ORF">CELE_K12B6.2</name>
        <name evidence="9" type="ORF">K12B6.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SOF58871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="W06H8.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3S7"/>
        </source>
    </evidence>
    <sequence length="608" mass="68689" checksum="CF9A5532AF28A22E" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3S8</accession>
    <name>A0A2C9C3S8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sugar transporter SWEET1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">swt-2</name>
        <name evidence="16" type="ORF">C54F6.4</name>
        <name evidence="14" type="ORF">CELE_C54F6.4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343831.1">
        <property type="nucleotide sequence ID" value="NM_001356698.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3S8"/>
    <dbReference type="SMR" id="A0A2C9C3S8"/>
    <dbReference type="GeneID" id="183804"/>
    <dbReference type="AGR" id="WB:WBGene00016922"/>
    <dbReference type="CTD" id="183804"/>
    <dbReference type="WormBase" id="C54F6.4b">
        <property type="protein sequence ID" value="CE52140"/>
        <property type="gene ID" value="WBGene00016922"/>
        <property type="gene designation" value="swt-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016922">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans)"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3S8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000004">
        <property type="entry name" value="Sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF43">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SOF58830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="C54F6.4b"/>
        </source>
    </evidence>
    <sequence length="197" mass="22451" checksum="97330AD0073B9CBD" modified="2017-12-20" version="1">MGTLVLPFWLRYGFLRNDVMLISINCAGIPIAVFNAMFFLYFSKPKKYYMTQLSIVTIIILTMLMLIHFNPNVQFLGFVCIVLNLITFGSPLAGLRVVLRDREVITLPFVLCLVQLIVQCLWNLYGILIQDFFLVIPTAVGIMISLVQLSLFLIFPRKRDGYSPMAKVARCVFGSSNNRKEVPDEPQKIVVESNTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3V8</accession>
    <name>A0A2C9C3V8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F44E7.7</name>
        <name evidence="2 4" type="ORF">F44E7.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3V8"/>
    <dbReference type="SMR" id="A0A2C9C3V8"/>
    <dbReference type="AGR" id="WB:WBGene00018429"/>
    <dbReference type="WormBase" id="F44E7.7c">
        <property type="protein sequence ID" value="CE52249"/>
        <property type="gene ID" value="WBGene00018429"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018429">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3V8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F44E7.7c"/>
        </source>
    </evidence>
    <sequence length="82" mass="9270" checksum="3EFEE33C4EFC660B" modified="2017-12-20" version="1">MGTVKCLQLRCQQHVHFATVVVAFMACIWQFLVPLGVGYLCPNNTPEEWSFLFFIVSGIVLIVNIPFPFLTTAEAADYAKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3Z4</accession>
    <name>A0A2C9C3Z4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dynamin-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">rme-1</name>
        <name evidence="15" type="ORF">CELE_W06H8.1</name>
        <name evidence="17" type="ORF">W06H8.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343865.1">
        <property type="nucleotide sequence ID" value="NM_001356657.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3Z4"/>
    <dbReference type="SMR" id="A0A2C9C3Z4"/>
    <dbReference type="GeneID" id="179010"/>
    <dbReference type="AGR" id="WB:WBGene00004373"/>
    <dbReference type="CTD" id="179010"/>
    <dbReference type="WormBase" id="W06H8.1g">
        <property type="protein sequence ID" value="CE52182"/>
        <property type="gene ID" value="WBGene00004373"/>
        <property type="gene designation" value="rme-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004373">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3Z4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00047761"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
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    </evidence>
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            <dbReference type="EMBL" id="CAH2125335.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="624" mass="71211" checksum="1F5AB3ACC8486F34" modified="2022-10-12" version="1"> </sequence>
</entry>
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    <accession>A0A8S4QF14</accession>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">Bristol N2</strain>
        </source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4QF14"/>
        </source>
    </evidence>
    <sequence length="454" mass="49738" checksum="A331C5513857B0E3" modified="2022-10-12" version="1">MDQTVLDSAFNSPVDSGIAGTTTGSGSTTHFGVGTNLRSSSRSTDGTDSTDGANSDNVTGSTGSTPAHHSITNLNMALSQHSIDSATAASSTNPFPHFNQADLLNFHQNSLLPHHMFSQFGRYPQFEQKPDVGVLQQQMQMREAKPYKCTQCVKAFANSSYLSQHMRIHLGIKPFGPCNYCGKKFTQLSHLQQHIRTHTGEKPYKCKFTGCDKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFTDEQSLLDHIPKHKESKHLKRLKIHICPFCGKSYTQQTYLQKHMTKHADRSKASNFGNDVVPADPFDPSLLSWNPMQGMGDNAHDSSSFNINQFAANTMIGSQSTNYNPAFQNSAFSQLFNIRNNRYLSEYPTSTKNGERAPGFNMITPLENIQRYNGSSSSATAVVTATGSAVVSSTPSSTSSSSAGSSSSQGGVFNPQSLINNMKNHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4SL56</accession>
    <name>A0A8S4SL56_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CELE_T24B8.4</name>
        <name evidence="3 5" type="ORF">T24B8.4</name>
    </gene>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="152"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH2659121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T24B8.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4SL56"/>
        </source>
    </evidence>
    <sequence length="776" mass="83734" checksum="C7D69955EB0CFAA1" modified="2022-10-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4SL65</accession>
    <name>A0A8S4SL65_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">par-2</name>
        <name evidence="1" type="ORF">CELE_F58B6.3</name>
        <name evidence="3" type="ORF">F58B6.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAH2662237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001407527.1">
        <property type="nucleotide sequence ID" value="NM_001420609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4SL65"/>
    <dbReference type="SMR" id="A0A8S4SL65"/>
    <dbReference type="GeneID" id="175275"/>
    <dbReference type="AGR" id="WB:WBGene00003917"/>
    <dbReference type="CTD" id="175275"/>
    <dbReference type="WormBase" id="F58B6.3e">
        <property type="protein sequence ID" value="CE54523"/>
        <property type="gene ID" value="WBGene00003917"/>
        <property type="gene designation" value="par-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH2662237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F58B6.3e"/>
        </source>
    </evidence>
    <sequence length="161" mass="17837" checksum="01B35E09CEE7B759" modified="2022-10-12" version="1">MMPFPEGDNRLPHIVSMVLNNDETDMEYVLDIIDPEYDNSNLPQAYMDACDAAYLLVDTRNPASILSAHQIHRNMKHAQHIHVQCEMLMNVPSEASGQTRVLSANALETTMKTIPIRDVCANQLDKGVVEEMLLSICERVTTARNPQTPTSSPIATSSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4SL80</accession>
    <name>A0A8S4SL80_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T24B8.4</name>
        <name evidence="2 4" type="ORF">T24B8.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4SL80"/>
    <dbReference type="AGR" id="WB:WBGene00011978"/>
    <dbReference type="WormBase" id="T24B8.4h">
        <property type="protein sequence ID" value="CE54540"/>
        <property type="gene ID" value="WBGene00011978"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877983at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH2659122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T24B8.4h"/>
        </source>
    </evidence>
    <sequence length="205" mass="22588" checksum="C009ACEA4BC9272B" modified="2022-10-12" version="1">MSPISSSVSSASAPSPSSLSAGSVSPDSTPKKRIVGSNANFEKAKEKWGAAPKADDSPPTTRGYLMRESKTPTREETTPVREKTPVKTIEEPKSKKHPFMSSNVPPSSLSAREQLFSSSSLPRHHRNSSNQNVINVPISAPWYSRDPIVNPEPPSVGSRRPSKQSTNPYRISFDEFTVPHPSQMRDNIRFNIDLSHDLPLSISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G1K100</accession>
    <name>G1K100_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_M04C3.5</name>
        <name evidence="1 3" type="ORF">M04C3.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCC42187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256862.1">
        <property type="nucleotide sequence ID" value="NM_001269933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K100"/>
    <dbReference type="GeneID" id="13218533"/>
    <dbReference type="AGR" id="WB:WBGene00206418"/>
    <dbReference type="CTD" id="13218533"/>
    <dbReference type="WormBase" id="M04C3.5b">
        <property type="protein sequence ID" value="CE46414"/>
        <property type="gene ID" value="WBGene00206418"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2962995_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00206418">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K100">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC42187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="M04C3.5b"/>
        </source>
    </evidence>
    <sequence length="59" mass="6867" checksum="C3C9D7CF3A5EB4E4" modified="2011-10-19" version="1">MTEVNEDTMRKSREILWPNGKIDSIGKQFSYLTRELPNESTVAFGTINITYKYLSKSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>G1K101</accession>
    <name>G1K101_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNF2 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_M04C3.2</name>
        <name evidence="2 4" type="ORF">M04C3.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCC42188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K101"/>
    <dbReference type="SMR" id="G1K101"/>
    <dbReference type="PeptideAtlas" id="G1K101"/>
    <dbReference type="AGR" id="WB:WBGene00010851"/>
    <dbReference type="WormBase" id="M04C3.2b">
        <property type="protein sequence ID" value="CE46290"/>
        <property type="gene ID" value="WBGene00010851"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_471927_0_0_1"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010851">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K101">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21516:SF4">
        <property type="entry name" value="AAA_LID_7 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21516">
        <property type="entry name" value="AAA_LID_7 DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNF2 N-terminal" evidence="1">
        <location>
            <begin position="264"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC42188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="M04C3.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="G1K101"/>
        </source>
    </evidence>
    <sequence length="578" mass="67559" checksum="6DD8CC6E1D5B2A65" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G1K102</accession>
    <name>G1K102_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spiroplasma plectrovirus-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_M04C3.5</name>
        <name evidence="1 3" type="ORF">M04C3.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCC42189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256861.1">
        <property type="nucleotide sequence ID" value="NM_001269932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K102"/>
    <dbReference type="GeneID" id="13218533"/>
    <dbReference type="AGR" id="WB:WBGene00206418"/>
    <dbReference type="CTD" id="13218533"/>
    <dbReference type="WormBase" id="M04C3.5d">
        <property type="protein sequence ID" value="CE46150"/>
        <property type="gene ID" value="WBGene00206418"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2442858_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00206418">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K102">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC42189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="M04C3.5d"/>
        </source>
    </evidence>
    <sequence length="90" mass="10732" checksum="8B78D72EDA78A9FD" modified="2011-10-19" version="1">MTCHKNFYELNYIDKDGRNKYIESVEYMKTFFSEVNEDTMRKSREILWPNGKIDSIGKQFSYLTRELPNESTVAFGTINITYKYLSKSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>G1K105</accession>
    <name>G1K105_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CELE_F22G12.4</name>
        <name evidence="9 11" type="ORF">F22G12.4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
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    <dbReference type="SMR" id="G1K105"/>
    <dbReference type="PeptideAtlas" id="G1K105"/>
    <dbReference type="GeneID" id="173180"/>
    <dbReference type="AGR" id="WB:WBGene00009064"/>
    <dbReference type="CTD" id="173180"/>
    <dbReference type="WormBase" id="F22G12.4c">
        <property type="protein sequence ID" value="CE46335"/>
        <property type="gene ID" value="WBGene00009064"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010618_0_0_1"/>
    <dbReference type="OrthoDB" id="2306477at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009064">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K105">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
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    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="561"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="683"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="752"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC42175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F22G12.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="G1K105"/>
        </source>
    </evidence>
    <sequence length="810" mass="88224" checksum="1B727800E820E1B6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>G1K106</accession>
    <name>G1K106_CAEEL</name>
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        <submittedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </submittedName>
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        <name evidence="9 11" type="ORF">F22G12.4</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001265157.1"/>
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    <dbReference type="SMR" id="G1K106"/>
    <dbReference type="PeptideAtlas" id="G1K106"/>
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    <dbReference type="AGR" id="WB:WBGene00009064"/>
    <dbReference type="CTD" id="173180"/>
    <dbReference type="WormBase" id="F22G12.4b">
        <property type="protein sequence ID" value="CE46473"/>
        <property type="gene ID" value="WBGene00009064"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010618_0_0_1"/>
    <dbReference type="OrthoDB" id="2306477at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009064">
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    </dbReference>
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        <property type="project" value="WormBase"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
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    </feature>
    <feature type="repeat" description="ANK" evidence="6">
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    <feature type="repeat" description="ANK" evidence="6">
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    <feature type="repeat" description="ANK" evidence="6">
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    </feature>
    <feature type="repeat" description="ANK" evidence="6">
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    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="776"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="845"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC42176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F22G12.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="G1K106"/>
        </source>
    </evidence>
    <sequence length="903" mass="98430" checksum="29CFC530A480146F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>G1K108</accession>
    <name>G1K108_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">atgp-2</name>
        <name evidence="6" type="ORF">C38C6.2</name>
        <name evidence="4" type="ORF">CELE_C38C6.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCC42154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254436.1">
        <property type="nucleotide sequence ID" value="NM_001267507.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K108"/>
    <dbReference type="SMR" id="G1K108"/>
    <dbReference type="PeptideAtlas" id="G1K108"/>
    <dbReference type="GeneID" id="175125"/>
    <dbReference type="AGR" id="WB:WBGene00000225"/>
    <dbReference type="CTD" id="175125"/>
    <dbReference type="WormBase" id="C38C6.2b">
        <property type="protein sequence ID" value="CE46309"/>
        <property type="gene ID" value="WBGene00000225"/>
        <property type="gene designation" value="atgp-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_8_0_1"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000225">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K108">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000334">
        <property type="entry name" value="Amino acid Transporter GlycoProtein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031984">
        <property type="entry name" value="SLC3A2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF230">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16028">
        <property type="entry name" value="SLC3A2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="97"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC42154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C38C6.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="G1K108"/>
        </source>
    </evidence>
    <sequence length="603" mass="68541" checksum="848BB6DA15746F85" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>G1K109</accession>
    <name>G1K109_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Basement membrane-specific heparan sulfate proteoglycan core protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">unc-52</name>
        <name evidence="6" type="ORF">CELE_ZC101.2</name>
        <name evidence="8" type="ORF">ZC101.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCC42155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254438.1">
        <property type="nucleotide sequence ID" value="NM_001267509.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K109"/>
    <dbReference type="SMR" id="G1K109"/>
    <dbReference type="PeptideAtlas" id="G1K109"/>
    <dbReference type="GeneID" id="175126"/>
    <dbReference type="AGR" id="WB:WBGene00006787"/>
    <dbReference type="CTD" id="175126"/>
    <dbReference type="WormBase" id="ZC101.2g">
        <property type="protein sequence ID" value="CE46415"/>
        <property type="gene ID" value="WBGene00006787"/>
        <property type="gene designation" value="unc-52"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000078_0_0_1"/>
    <dbReference type="OrthoDB" id="10055367at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006787">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K109">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031581">
        <property type="term" value="P:hemidesmosome assembly"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048644">
        <property type="term" value="P:muscle organ morphogenesis"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:001396">
        <property type="entry name" value="Basement membrane proteoglycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000286">
        <property type="entry name" value="Basement membrane proteoglycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="210"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="294"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="638"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="681"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC42155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="ZC101.2g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="G1K109"/>
        </source>
    </evidence>
    <sequence length="876" mass="96929" checksum="B7F4C3B0B43E0F4A" modified="2011-10-19" version="1"> </sequence>
</entry>
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    <accession>G1K110</accession>
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        <submittedName>
            <fullName evidence="2">Aamy domain-containing protein</fullName>
        </submittedName>
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        <name evidence="2 4" type="primary">atgp-2</name>
        <name evidence="4" type="ORF">C38C6.2</name>
        <name evidence="2" type="ORF">CELE_C38C6.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCC42156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254437.1">
        <property type="nucleotide sequence ID" value="NM_001267508.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1K110"/>
    <dbReference type="SMR" id="G1K110"/>
    <dbReference type="PeptideAtlas" id="G1K110"/>
    <dbReference type="GeneID" id="175125"/>
    <dbReference type="AGR" id="WB:WBGene00000225"/>
    <dbReference type="CTD" id="175125"/>
    <dbReference type="WormBase" id="C38C6.2c">
        <property type="protein sequence ID" value="CE46420"/>
        <property type="gene ID" value="WBGene00000225"/>
        <property type="gene designation" value="atgp-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_8_0_1"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000225">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G1K110">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF230">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="1">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC42156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C38C6.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="G1K110"/>
        </source>
    </evidence>
    <sequence length="191" mass="21229" checksum="CA8371FC647D1F15" modified="2011-10-19" version="1">MVLQMILPGTNNIYYGEEIGMRNLANDSRVPPQKGAMQWDDSLNGGFTSAISPPVPSNIDVANINWKRQYAEPQSTLKIFAKLAKLRQREDALMTGTTLIGRLVDGAFTITRFNNFENRTTGNIYVAALNFAEHPVKLPLTDLPSNSKLHKSTIVTATSNCVAYYARQTVDFGLKEIELEPNEGVVFRYSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-10-05" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>G5EET6-2</accession>
    <name>EFA6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform a of Exchange factor for Arf-6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Arf guanine nucleotide exchange factor efa-6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pleckstrin homology domain-containing protein efa-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 11" type="primary">efa-6</name>
        <name evidence="11" type="ORF">Y55D9A.1</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="8 10">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="PLoS Genet." volume="3" first="E128" last="E128">
            <title>Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants.</title>
            <authorList>
                <person name="O'Rourke S.M."/>
                <person name="Dorfman M.D."/>
                <person name="Carter J.C."/>
                <person name="Bowerman B."/>
            </authorList>
            <dbReference type="PubMed" id="17676955"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.0030128"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C)</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Nat. Cell Biol." volume="12" first="1235" last="1241">
            <title>Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex.</title>
            <authorList>
                <person name="O'Rourke S.M."/>
                <person name="Christensen S.N."/>
                <person name="Bowerman B."/>
            </authorList>
            <dbReference type="PubMed" id="21076413"/>
            <dbReference type="DOI" id="10.1038/ncb2128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-449</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Neuron" volume="71" first="1043" last="1057">
            <title>Axon regeneration pathways identified by systematic genetic screening in C. elegans.</title>
            <authorList>
                <person name="Chen L."/>
                <person name="Wang Z."/>
                <person name="Ghosh-Roy A."/>
                <person name="Hubert T."/>
                <person name="Yan D."/>
                <person name="O'Rourke S."/>
                <person name="Bowerman B."/>
                <person name="Wu Z."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="21943602"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2011.07.009"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-449</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2015" name="Elife" volume="4" first="0" last="0">
            <title>Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase.</title>
            <authorList>
                <person name="Chen L."/>
                <person name="Chuang M."/>
                <person name="Koorman T."/>
                <person name="Boxem M."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="26339988"/>
            <dbReference type="DOI" id="10.7554/eLife.08695"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH TAC-1 AND ZYG-8</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EET6-4</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_058546"/>
        </isoform>
        <isoform>
            <id>G5EET6-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_058547"/>
        </isoform>
        <isoform>
            <id>G5EET6-3</id>
            <name evidence="1 4">c</name>
            <sequence type="described" ref="VSP_058548 VSP_058547"/>
        </isoform>
        <isoform>
            <id>G5EET6-1</id>
            <name evidence="1 4">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_502417.1">
        <property type="nucleotide sequence ID" value="NM_070016.7"/>
    </dbReference>
    <dbReference type="WormBase" id="Y55D9A.1a">
        <property type="protein sequence ID" value="CE19234"/>
        <property type="gene ID" value="WBGene00013223"/>
        <property type="gene designation" value="efa-6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="17676955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="21943602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="26339988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="ABQ42569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="ABQ42570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="CAA21701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="CAC70120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="EMBL" id="CAM82814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="Y55D9A.1a"/>
        </source>
    </evidence>
    <sequence length="816" mass="90450" checksum="0049910DC458F2E6" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-10-05" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>G5EET6-3</accession>
    <name>EFA6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform c of Exchange factor for Arf-6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Arf guanine nucleotide exchange factor efa-6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pleckstrin homology domain-containing protein efa-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 11" type="primary">efa-6</name>
        <name evidence="11" type="ORF">Y55D9A.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="8 10">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="PLoS Genet." volume="3" first="E128" last="E128">
            <title>Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants.</title>
            <authorList>
                <person name="O'Rourke S.M."/>
                <person name="Dorfman M.D."/>
                <person name="Carter J.C."/>
                <person name="Bowerman B."/>
            </authorList>
            <dbReference type="PubMed" id="17676955"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.0030128"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C)</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Nat. Cell Biol." volume="12" first="1235" last="1241">
            <title>Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex.</title>
            <authorList>
                <person name="O'Rourke S.M."/>
                <person name="Christensen S.N."/>
                <person name="Bowerman B."/>
            </authorList>
            <dbReference type="PubMed" id="21076413"/>
            <dbReference type="DOI" id="10.1038/ncb2128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-449</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Neuron" volume="71" first="1043" last="1057">
            <title>Axon regeneration pathways identified by systematic genetic screening in C. elegans.</title>
            <authorList>
                <person name="Chen L."/>
                <person name="Wang Z."/>
                <person name="Ghosh-Roy A."/>
                <person name="Hubert T."/>
                <person name="Yan D."/>
                <person name="O'Rourke S."/>
                <person name="Bowerman B."/>
                <person name="Wu Z."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="21943602"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2011.07.009"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-449</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2015" name="Elife" volume="4" first="0" last="0">
            <title>Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase.</title>
            <authorList>
                <person name="Chen L."/>
                <person name="Chuang M."/>
                <person name="Koorman T."/>
                <person name="Boxem M."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="26339988"/>
            <dbReference type="DOI" id="10.7554/eLife.08695"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH TAC-1 AND ZYG-8</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EET6-3</id>
            <name evidence="1 4">c</name>
            <sequence type="described" ref="VSP_058548 VSP_058547"/>
        </isoform>
        <isoform>
            <id>G5EET6-4</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_058546"/>
        </isoform>
        <isoform>
            <id>G5EET6-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_058547"/>
        </isoform>
        <isoform>
            <id>G5EET6-1</id>
            <name evidence="1 4">b</name>
            <sequence type="displayed"/>
        </isoform>
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    <dbReference type="RefSeq" id="NP_001122818.1">
        <property type="nucleotide sequence ID" value="NM_001129346.3"/>
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    <dbReference type="WormBase" id="Y55D9A.1c">
        <property type="protein sequence ID" value="CE40826"/>
        <property type="gene ID" value="WBGene00013223"/>
        <property type="gene designation" value="efa-6"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="21943602"/>
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    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="26339988"/>
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    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="9851916"/>
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    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="ABQ42569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="ABQ42570.1"/>
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    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="CAA21701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="CAC70120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="EMBL" id="CAM82814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="Y55D9A.1a"/>
        </source>
    </evidence>
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    <reference evidence="7 8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="8 10">Bristol N2</strain>
        </source>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="PLoS Genet." volume="3" first="E128" last="E128">
            <title>Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants.</title>
            <authorList>
                <person name="O'Rourke S.M."/>
                <person name="Dorfman M.D."/>
                <person name="Carter J.C."/>
                <person name="Bowerman B."/>
            </authorList>
            <dbReference type="PubMed" id="17676955"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.0030128"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C)</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Nat. Cell Biol." volume="12" first="1235" last="1241">
            <title>Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex.</title>
            <authorList>
                <person name="O'Rourke S.M."/>
                <person name="Christensen S.N."/>
                <person name="Bowerman B."/>
            </authorList>
            <dbReference type="PubMed" id="21076413"/>
            <dbReference type="DOI" id="10.1038/ncb2128"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-449</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Neuron" volume="71" first="1043" last="1057">
            <title>Axon regeneration pathways identified by systematic genetic screening in C. elegans.</title>
            <authorList>
                <person name="Chen L."/>
                <person name="Wang Z."/>
                <person name="Ghosh-Roy A."/>
                <person name="Hubert T."/>
                <person name="Yan D."/>
                <person name="O'Rourke S."/>
                <person name="Bowerman B."/>
                <person name="Wu Z."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="21943602"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2011.07.009"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-449</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2015" name="Elife" volume="4" first="0" last="0">
            <title>Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase.</title>
            <authorList>
                <person name="Chen L."/>
                <person name="Chuang M."/>
                <person name="Koorman T."/>
                <person name="Boxem M."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="26339988"/>
            <dbReference type="DOI" id="10.7554/eLife.08695"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH TAC-1 AND ZYG-8</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EET6-4</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_058546"/>
        </isoform>
        <isoform>
            <id>G5EET6-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_058547"/>
        </isoform>
        <isoform>
            <id>G5EET6-3</id>
            <name evidence="1 4">c</name>
            <sequence type="described" ref="VSP_058548 VSP_058547"/>
        </isoform>
        <isoform>
            <id>G5EET6-1</id>
            <name evidence="1 4">b</name>
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        </isoform>
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    <dbReference type="RefSeq" id="NP_001255652.1">
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    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="17676955"/>
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    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="21943602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="26339988"/>
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    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="ABQ42569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="ABQ42570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="CAA21701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="CAC70120.1"/>
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    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="EMBL" id="CAM82814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="Y55D9A.1a"/>
        </source>
    </evidence>
    <sequence length="634" mass="70786" checksum="97F0EF50D6C9D786" modified="2011-12-14" version="1"> </sequence>
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    <accession>G5EGC9-2</accession>
    <name>PES1_CAEEL</name>
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        <recommendedName>
            <fullName evidence="2">Isoform b of Forkhead box protein pes-1</fullName>
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            <fullName evidence="1">Pattern expression site 1</fullName>
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    <gene>
        <name evidence="7" type="primary">pes-1</name>
        <name evidence="7" type="ORF">T28H11.4</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="journal article" date="1994" name="Development" volume="120" first="505" last="514">
            <title>PES-1 is expressed during early embryogenesis in Caenorhabditis elegans and has homology to the fork head family of transcription factors.</title>
            <authorList>
                <person name="Hope I.A."/>
            </authorList>
            <dbReference type="PubMed" id="8162851"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain evidence="3 4 5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="1999" name="Genetics" volume="151" first="131" last="141">
            <title>Complexity of developmental control: analysis of embryonic cell lineage specification in Caenorhabditis elegans using pes-1 as an early marker.</title>
            <authorList>
                <person name="Molin L."/>
                <person name="Schnabel H."/>
                <person name="Kaletta T."/>
                <person name="Feichtinger R."/>
                <person name="Hope I.A."/>
                <person name="Schnabel R."/>
            </authorList>
            <dbReference type="PubMed" id="9872954"/>
            <dbReference type="DOI" id="10.1093/genetics/151.1.131"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2000" name="Development" volume="127" first="4825" last="4835">
            <title>Evolutionary conservation of redundancy between a diverged pair of forkhead transcription factor homologues.</title>
            <authorList>
                <person name="Molin L."/>
                <person name="Mounsey A."/>
                <person name="Aslam S."/>
                <person name="Bauer P."/>
                <person name="Young J."/>
                <person name="James M."/>
                <person name="Sharma-Oates A."/>
                <person name="Hope I.A."/>
            </authorList>
            <dbReference type="PubMed" id="11044397"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EGC9-2</id>
            <name evidence="8">b</name>
            <sequence type="described" ref="VSP_061478"/>
        </isoform>
        <isoform>
            <id>G5EGC9-1</id>
            <name evidence="7">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001380128.1">
        <property type="nucleotide sequence ID" value="NM_001392306.1"/>
    </dbReference>
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        <property type="gene ID" value="WBGene00003976"/>
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    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="8162851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="CAA82224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAA82225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="CAA82226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T28H11.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T28H11.4b"/>
        </source>
    </evidence>
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    <accession>G8JYC6-2</accession>
    <name>PDF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Pigment dispersing factor homolog pdf-1</fullName>
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    <gene>
        <name evidence="5" type="primary">pdf-1</name>
        <name evidence="5" type="ORF">T07E3.6</name>
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    <organism>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2008" name="J. Biol. Chem." volume="283" first="15241" last="15249">
            <title>Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Janssen T."/>
                <person name="Husson S.J."/>
                <person name="Lindemans M."/>
                <person name="Mertens I."/>
                <person name="Rademakers S."/>
                <person name="Donck K.V."/>
                <person name="Geysen J."/>
                <person name="Jansen G."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="18390545"/>
            <dbReference type="DOI" id="10.1074/jbc.M709060200"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2009" name="J. Neurochem." volume="111" first="228" last="241">
            <title>Discovery and characterization of a conserved pigment dispersing factor-like neuropeptide pathway in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Janssen T."/>
                <person name="Husson S.J."/>
                <person name="Meelkop E."/>
                <person name="Temmerman L."/>
                <person name="Lindemans M."/>
                <person name="Verstraelen K."/>
                <person name="Rademakers S."/>
                <person name="Mertens I."/>
                <person name="Nitabach M."/>
                <person name="Jansen G."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="19686386"/>
            <dbReference type="DOI" id="10.1111/j.1471-4159.2009.06323.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2012" name="Mol. Cell. Endocrinol." volume="361" first="232" last="240">
            <title>PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying.</title>
            <authorList>
                <person name="Meelkop E."/>
                <person name="Temmerman L."/>
                <person name="Janssen T."/>
                <person name="Suetens N."/>
                <person name="Beets I."/>
                <person name="Van Rompay L."/>
                <person name="Shanmugam N."/>
                <person name="Husson S.J."/>
                <person name="Schoofs L."/>
            </authorList>
            <dbReference type="PubMed" id="22579613"/>
            <dbReference type="DOI" id="10.1016/j.mce.2012.05.001"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2012" name="Nat. Neurosci." volume="15" first="1675" last="1682">
            <title>PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans.</title>
            <authorList>
                <person name="Barrios A."/>
                <person name="Ghosh R."/>
                <person name="Fang C."/>
                <person name="Emmons S.W."/>
                <person name="Barr M.M."/>
            </authorList>
            <dbReference type="PubMed" id="23143519"/>
            <dbReference type="DOI" id="10.1038/nn.3253"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="Cell" volume="154" first="1023" last="1035">
            <title>Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans.</title>
            <authorList>
                <person name="Flavell S.W."/>
                <person name="Pokala N."/>
                <person name="Macosko E.Z."/>
                <person name="Albrecht D.R."/>
                <person name="Larsch J."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="23972393"/>
            <dbReference type="DOI" id="10.1016/j.cell.2013.08.001"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="7">
        <citation type="journal article" date="2013" name="Neuron" volume="78" first="869" last="880">
            <title>Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans.</title>
            <authorList>
                <person name="Choi S."/>
                <person name="Chatzigeorgiou M."/>
                <person name="Taylor K.P."/>
                <person name="Schafer W.R."/>
                <person name="Kaplan J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23764289"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2013.04.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="8">
        <citation type="journal article" date="2015" name="Genes Brain Behav." volume="14" first="493" last="501">
            <title>Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Herrero A."/>
                <person name="Romanowski A."/>
                <person name="Meelkop E."/>
                <person name="Caldart C.S."/>
                <person name="Schoofs L."/>
                <person name="Golombek D.A."/>
            </authorList>
            <dbReference type="PubMed" id="26113231"/>
            <dbReference type="DOI" id="10.1111/gbb.12231"/>
        </citation>
        <scope>FUNCTION</scope>
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    <reference evidence="1" key="9">
        <citation type="journal article" date="2016" name="Genetics" volume="204" first="1151" last="1159">
            <title>The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion.</title>
            <authorList>
                <person name="Chen D."/>
                <person name="Taylor K.P."/>
                <person name="Hall Q."/>
                <person name="Kaplan J.M."/>
            </authorList>
            <dbReference type="PubMed" id="27585848"/>
            <dbReference type="DOI" id="10.1534/genetics.116.192898"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="10">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans.</title>
            <authorList>
                <person name="Hilbert Z.A."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30024377"/>
            <dbReference type="DOI" id="10.7554/elife.36547"/>
        </citation>
        <scope>FUNCTION</scope>
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        <event type="alternative splicing"/>
        <isoform>
            <id>G8JYC6-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G8JYC6-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_061252"/>
        </isoform>
    </comment>
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        <property type="nucleotide sequence ID" value="NM_001392134.1"/>
    </dbReference>
    <dbReference type="WormBase" id="T07E3.6b">
        <property type="protein sequence ID" value="CE52158"/>
        <property type="gene ID" value="WBGene00020317"/>
        <property type="gene designation" value="pdf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
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        <source>
            <dbReference type="EMBL" id="ABO42258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="ABO42259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T07E3.6a"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="T07E3.6b"/>
        </source>
    </evidence>
    <sequence length="86" mass="9330" checksum="4AB84B246282CDAE" modified="2017-12-20" version="1" precursor="true">MNRFIISMIALLAVFCAVSTASPLLYRAPQMYDDVQFVKRSNAELINGLIGMDLGKLSAVGKRSNAELINGLLSMNLNKLSGAGRR</sequence>
</entry>
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        <submittedName>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
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    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
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    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCJ09395.1"/>
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        <property type="nucleotide sequence ID" value="NM_001276728.3"/>
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        <property type="protein sequence ID" value="CE47739"/>
        <property type="gene ID" value="WBGene00018819"/>
        <property type="gene designation" value="rog-1"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
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    <dbReference type="Bgee" id="WBGene00018819">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="I7LFE2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
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        <property type="entry name" value="FRS2_PTB"/>
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        <property type="entry name" value="IRS_PTB"/>
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        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCJ09395.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="F54D12.6b"/>
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    </evidence>
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    <accession>I7LFE6</accession>
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        <submittedName>
            <fullName evidence="11">EGF-like domain-containing protein</fullName>
        </submittedName>
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        <name evidence="11" type="ORF">CELE_ZK783.1</name>
        <name evidence="13" type="ORF">ZK783.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCJ09405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263715.1">
        <property type="nucleotide sequence ID" value="NM_001276786.3"/>
    </dbReference>
    <dbReference type="GeneID" id="176076"/>
    <dbReference type="AGR" id="WB:WBGene00022816"/>
    <dbReference type="CTD" id="176076"/>
    <dbReference type="WormBase" id="ZK783.1f">
        <property type="protein sequence ID" value="CE47720"/>
        <property type="gene ID" value="WBGene00022816"/>
        <property type="gene designation" value="fbn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022816">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="I7LFE6">
        <property type="expression patterns" value="baseline and differential"/>
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    <dbReference type="GO" id="GO:0005509">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Dumpy, isoform I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="9"/>
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        <property type="match status" value="17"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
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        <property type="match status" value="9"/>
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        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
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    <feature type="chain" id="PRO_5003711908" evidence="8">
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            <end position="2703"/>
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    </feature>
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        <location>
            <begin position="2667"/>
            <end position="2687"/>
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    <feature type="domain" description="EGF-like" evidence="9">
        <location>
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            <end position="130"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
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            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="172"/>
            <end position="211"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="344"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1431"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1473"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1565"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1606"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1699"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1838"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1879"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="2176"/>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="2308"/>
            <end position="2348"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCJ09420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="R13H4.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="I7LFF2"/>
        </source>
    </evidence>
    <sequence length="883" mass="98447" checksum="CBC0705741B75480" modified="2012-10-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>O17273</accession>
    <name>O17273_CAEEL</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="2 4" type="ORF">T27A1.2</name>
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        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD73625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F88022">
        <property type="entry name" value="F88022"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="O17273"/>
    <dbReference type="GeneID" id="188963"/>
    <dbReference type="UCSC" id="T27A1.2">
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    <dbReference type="CTD" id="188963"/>
    <dbReference type="WormBase" id="T27A1.2a">
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        <property type="gene ID" value="WBGene00020834"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049370_1_0_1"/>
    <dbReference type="OMA" id="CIRETEC"/>
    <dbReference type="PhylomeDB" id="O17273"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020834">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O17273">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012885">
        <property type="entry name" value="F-box_Sdz-33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21503:SF8">
        <property type="entry name" value="F-BOX ASSOCIATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07735">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="142"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD73625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T27A1.2a"/>
        </source>
    </evidence>
    <sequence length="283" mass="34014" checksum="6C38B7498FDCC24F" modified="2004-03-01" version="2">MQFAYHFMMNQEQGINWATHQNVHYFINLFCTYHKDVNKSPCLSYETSQELINLLGILNDSFKIDHVELAMERDEIFGEFKSALSHPLFRKCHFVKVLGELSFVDTEDVEFILKNFDLKFGFSNCSFQLVGFNKKLIKLFYNIPRLDLRRCPKLTLDDLKLMNCETIRFDYFGGFSGIQLNWHIQYWFAGNMSKLRRFQLNYWPYEWTDDLCDGLPHSEWNPKRRARYFYDDLEVVDCLKGRDIERSDGLLATILVEYDTMYFLIWHDRFPMDQQTLFRFTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>O17275</accession>
    <name>O17275_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF472">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD73629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="T27A1.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="O17275"/>
        </source>
    </evidence>
    <sequence length="344" mass="38501" checksum="FFBD2694221DD7C7" modified="2012-01-25" version="2">MDYANVMRSAVELGPAWIRGHGYLFKQMVNINMFVAQFGFCCVYFVFMADNLKQFFDQTSSIHISQAGWIALLLIPISALCTIRELKALAPLAAVANFVYIIAVVIVLADLFSDWQPLDSLPAFGAVENLPLFFGTVMFAFEGVAVVLPIENQMNEPIHFITPNGVLNTSCILVLLVYMTVGFFGFLRYGNDIKDTLTLNLPQTPFYQAIKVMFVLCILVSYPLQFYVPMERVEKWIKRKVVEAKQEPMIYAIRFGGVLLTCAMAQLIPHLALFISLVGSVAGTSLTLVFPPLIELLCSYSKQELTKWVWIRNIGLMAFAMVGFTTGTYASMVQIIEAFGKEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>O44841</accession>
    <name>O44841_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class I</fullName>
        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_494300.1">
        <property type="nucleotide sequence ID" value="NM_061899.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O44841"/>
    <dbReference type="PaxDb" id="6239-F33H12.5"/>
    <dbReference type="GeneID" id="191910"/>
    <dbReference type="UCSC" id="F33H12.5">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00005548"/>
    <dbReference type="CTD" id="191910"/>
    <dbReference type="WormBase" id="F33H12.5a">
        <property type="protein sequence ID" value="CE25868"/>
        <property type="gene ID" value="WBGene00005548"/>
        <property type="gene designation" value="sri-36"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TJHZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067919_1_0_1"/>
    <dbReference type="InParanoid" id="O44841"/>
    <dbReference type="OMA" id="QISALVW"/>
    <dbReference type="PhylomeDB" id="O44841"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005548">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019429">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sri"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45830">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45830:SF19">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10327">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="65"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="212"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="263"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="317" mass="36239" checksum="1E9276BB369214F0" modified="2001-10-01" version="2">MTINFTTPVWLIRYYYIVGTVSLIINFGTSYLVIAKSEKIDGIRYLLLVFQFLCTITNINFTLLMQPMSLFPIMAAYCNGVLVKVFNIYSHYLLAVWTSLLISEIVCLTICFAWKHRKISKLANRLNDGTYNLLAVFAIFIALSYYFLATQMDVKREFQMQYVREMYPDYYDQFQSLKNFVIYTENTWATLGIITCSIGSLFCGTVLTYTTIDMLKILKKLKMKISSNSYTRYKNAVKSLLAHFYTSLLSILPVTAAMIVMYAKIENGQDLVNGAAAIGGLHSSVNAVVLITFTIPYRKFVIRKSAEIFGVRNIAMF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>P34325-2</accession>
    <name>CYK7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Cytokinesis defective protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cyk-7</name>
        <name evidence="1" type="ORF">C08C3.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34325-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34325-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_032728 VSP_032727"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001040846.1">
        <property type="nucleotide sequence ID" value="NM_001047381.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C08C3.4b">
        <property type="protein sequence ID" value="CE39671"/>
        <property type="gene ID" value="WBGene00015591"/>
        <property type="gene designation" value="cyk-7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="C08C3.4a"/>
        </source>
    </evidence>
    <sequence length="248" mass="28261" checksum="39F8AA38DE24598E" modified="2008-04-08" version="2">MTNRETSDDVVIARSSFDDFSQSTPWRKFEISCGNRSFFVNPGWLAELSPYFADELYVRKPNVQRYVIDQATPDEVLEFLRCITFCPMRKPLTVKNVSLVLTFANRFEMRPVQARCENFIAQNATSLSRDKTKLFQVTCAMSQCDPNSSTMSVLVDKLAGIKDDELSRLHFAEMPGDVVAEVYAQKIQRTKDKKAQRQAGASDETAAGCCFMQWASSLFNRRRQRNQADQSILPPSGDQQHHRSELHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>P45895-2</accession>
    <name>CHSSB_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Chondroitin sulfate synthase mig-22</fullName>
            <ecNumber>2.4.1.175</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Abnormal cell migration</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chondroitin-polymerizing factor</fullName>
            <shortName evidence="1">ChPF</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1</fullName>
            <ecNumber>2.4.1.226</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mig-22</name>
        <name type="synonym">pfc-1</name>
        <name type="ORF">PAR2.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="53755" last="53761">
            <title>Nematode chondroitin polymerizing factor showing cell-/organ-specific expression is indispensable for chondroitin synthesis and embryonic cell division.</title>
            <authorList>
                <person name="Izumikawa T."/>
                <person name="Kitagawa H."/>
                <person name="Mizuguchi S."/>
                <person name="Nomura K.H."/>
                <person name="Nomura K."/>
                <person name="Tamura J."/>
                <person name="Gengyo-Ando K."/>
                <person name="Mitani S."/>
                <person name="Sugahara K."/>
            </authorList>
            <dbReference type="PubMed" id="15485872"/>
            <dbReference type="DOI" id="10.1074/jbc.M409615200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Dev. Biol." volume="300" first="635" last="646">
            <title>Chondroitin acts in the guidance of gonadal distal tip cells in C. elegans.</title>
            <authorList>
                <person name="Suzuki N."/>
                <person name="Toyoda H."/>
                <person name="Sano M."/>
                <person name="Nishiwaki K."/>
            </authorList>
            <dbReference type="PubMed" id="16982046"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2006.08.037"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="J. Biol. Chem." volume="282" first="8533" last="8544">
            <title>Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.</title>
            <authorList>
                <person name="Kitagawa H."/>
                <person name="Izumikawa T."/>
                <person name="Mizuguchi S."/>
                <person name="Dejima K."/>
                <person name="Nomura K.H."/>
                <person name="Egusa N."/>
                <person name="Taniguchi F."/>
                <person name="Tamura J."/>
                <person name="Gengyo-Ando K."/>
                <person name="Mitani S."/>
                <person name="Nomura K."/>
                <person name="Sugahara K."/>
            </authorList>
            <dbReference type="PubMed" id="17237233"/>
            <dbReference type="DOI" id="10.1074/jbc.M611107200"/>
        </citation>
        <scope>INTERACTION WITH SQV-5</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P45895-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_019778"/>
        </isoform>
        <isoform>
            <id>P45895-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.4.1.175"/>
    <dbReference type="EC" id="2.4.1.226"/>
    <dbReference type="RefSeq" id="NP_001360092.1">
        <property type="nucleotide sequence ID" value="NM_001372637.3"/>
    </dbReference>
    <dbReference type="WormBase" id="PAR2.4b">
        <property type="protein sequence ID" value="CE32699"/>
        <property type="gene ID" value="WBGene00003253"/>
        <property type="gene designation" value="mig-22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="15485872"/>
        </source>
    </evidence>
    <sequence length="606" mass="69200" checksum="D93977F40E22A1CA" modified="1995-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-10-25" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>P91535-2</accession>
    <name>SRG20_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Serpentine receptor class gamma-20</fullName>
            <shortName>Protein srg-20</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">srg-20</name>
        <name type="ORF">ZC204.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P91535-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P91535-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_020532"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022490.1">
        <property type="nucleotide sequence ID" value="NM_001027319.3"/>
    </dbReference>
    <dbReference type="WormBase" id="ZC204.4a">
        <property type="protein sequence ID" value="CE36350"/>
        <property type="gene ID" value="WBGene00005177"/>
        <property type="gene designation" value="srg-20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="337" mass="38428" checksum="6F4B74423854784E" modified="2006-09-19" version="4">MSTRLIIPANFSYDDPLPFTCNQDSHVMLSILEYLVQATYLSVSAVLNSMIVYTIFRCKGKHSYRRNPFFVLYAAEAVMNVYSCVIEVLFGRLIIYMTPLCPALSPFFFTPSILTKLYFLLNHYCLAFKTLSQIAISFNRMTCVIFPVHHFKLWQNILAPVLVSLFVLPLGVTWNILVSRVYVNPNGAGFSVNYRDAVAWANISFLHLFHCIPCLFLMIVFFLASIFGLTMLENRLRSAERSLIIFTMTLGVETMLFAIAQIYFAFLAGYLPGIRPLMLLISFNVFDVLYVYSPIALILMNRQLRRDIFHLKGDDPGFLSASSHNQPAARVMAPVMH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-11-27" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>P91820-2</accession>
    <name>LST1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Lateral signaling target 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lst-1</name>
        <name evidence="3" type="ORF">T22A3.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="48968" last="48968">
            <title>A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity.</title>
            <authorList>
                <person name="Qiu C."/>
                <person name="Bhat V.D."/>
                <person name="Rajeev S."/>
                <person name="Zhang C."/>
                <person name="Lasley A.E."/>
                <person name="Wine R.N."/>
                <person name="Campbell Z.T."/>
                <person name="Hall T.M.T."/>
            </authorList>
            <dbReference type="PubMed" id="31397673"/>
            <dbReference type="DOI" id="10.7554/eLife.48968"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 74-98 IN COMPLEX WITH FBF-2 164-575 AND RNA</scope>
        <scope>INTERACTION WITH FBF-2</scope>
        <scope>MUTAGENESIS OF LEU-76; LYS-80; LEU-83 AND TYR-85</scope>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2022" name="Nucleic Acids Res." volume="50" first="536" last="548">
            <title>Bipartite interaction sites differentially modulate RNA-binding affinity of a protein complex essential for germline stem cell self-renewal.</title>
            <authorList>
                <person name="Qiu C."/>
                <person name="Wine R.N."/>
                <person name="Campbell Z.T."/>
                <person name="Hall T.M.T."/>
            </authorList>
            <dbReference type="PubMed" id="34908132"/>
            <dbReference type="DOI" id="10.1093/nar/gkab1220"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.34 ANGSTROMS) OF 19-50 IN COMPLEX WITH FBF-2 164-575 AND RNA</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>INTERACTION WITH FBF-2</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF 76-LEU--GLN-79; 85-TYR--LYS-88 AND TYR-85</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2023" name="Nat. Commun." volume="14" first="7323" last="7323">
            <title>Intra- and inter-molecular regulation by intrinsically-disordered regions governs PUF protein RNA binding.</title>
            <authorList>
                <person name="Qiu C."/>
                <person name="Zhang Z."/>
                <person name="Wine R.N."/>
                <person name="Campbell Z.T."/>
                <person name="Zhang J."/>
                <person name="Hall T.M.T."/>
            </authorList>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH FBF-2</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P91820-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P91820-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_062455"/>
        </isoform>
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        <property type="nucleotide sequence ID" value="NM_001392939.1"/>
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        <property type="protein sequence ID" value="CE38421"/>
        <property type="gene ID" value="WBGene00003083"/>
        <property type="gene designation" value="lst-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T22A3.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T22A3.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="5">
        <source>
            <dbReference type="PDB" id="6PUN"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="6">
        <source>
            <dbReference type="PDB" id="7RZZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7S02"/>
        </source>
    </evidence>
    <sequence length="234" mass="26196" checksum="C04D63EECF37BFC7" modified="2018-03-28" version="3">MIPQQQHYHAFDRPTHYNSRKTSGPPPLMRTPSSGFSSASSSENMFSGLTLSDNENKIHEIMDPSVDVDLDMFLLPDCRYKQPVQPSTSTSRNNVSQISGSSRLNGSTRHVAPIVPKVAMPSELSYANVKRSSGYVDYMPTTYNSNVTSNSSAASVPMSPGTWVRCHYCWESYVKLCQRVANLEPLISCDGPWNWHTLYDMQGRVTCPRLWFAQLDRAGSEMVEQMGHARNVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q17728</accession>
    <name>Q17728_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2 4" type="ORF">C06E4.2</name>
        <name evidence="2" type="ORF">CELE_C06E4.2</name>
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    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD63337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29802">
        <property type="entry name" value="T29802"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_501158.1">
        <property type="nucleotide sequence ID" value="NM_068757.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q17728"/>
    <dbReference type="DIP" id="DIP-27236N"/>
    <dbReference type="IntAct" id="Q17728">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="182325"/>
    <dbReference type="UCSC" id="C06E4.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00015531"/>
    <dbReference type="CTD" id="182325"/>
    <dbReference type="WormBase" id="C06E4.2a">
        <property type="protein sequence ID" value="CE03950"/>
        <property type="gene ID" value="WBGene00015531"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TJ2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2560372_0_0_1"/>
    <dbReference type="OrthoDB" id="5781984at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015531">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q17728">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004185979" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C06E4.2a"/>
        </source>
    </evidence>
    <sequence length="82" mass="9058" checksum="E6CAC722EBB125B6" modified="1996-11-01" version="1">MNPMSSTLLIFLITILLASVKADSEVTESSDIKQSSAQAVAPTQFQIATSPHPFSRQIAAPSRIHRRSITPVPIRAHRVYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="168" xmlns="https://uniprot.org/uniprot">
    <accession>Q17744</accession>
    <name>Q17744_CAEEL</name>
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        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_F43B10.1</name>
        <name evidence="5 7" type="ORF">F43B10.1</name>
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    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
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        <interactant intactId="EBI-2315966">
            <id>Q17744</id>
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        <interactant intactId="EBI-312747">
            <id>O18302</id>
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        <organismsDiffer>false</organismsDiffer>
        <experiments>4</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-2315966">
            <id>Q17744</id>
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        <interactant intactId="EBI-325337">
            <id>G5EC32</id>
            <label>sorb-1</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>6</experiments>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63412.1"/>
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        <property type="entry name" value="T30080"/>
    </dbReference>
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        <property type="entry name" value="PP2A-F43B10.1 phosphatase complex"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="UCSC" id="C06G1.5">
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    <dbReference type="AGR" id="WB:WBGene00018373"/>
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    <dbReference type="WormBase" id="F43B10.1c">
        <property type="protein sequence ID" value="CE37187"/>
        <property type="gene ID" value="WBGene00018373"/>
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    <dbReference type="OrthoDB" id="5586at2759"/>
    <dbReference type="PhylomeDB" id="Q17744"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018373">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q17744">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
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        <property type="project" value="ComplexPortal"/>
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    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PPP2R3A_B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein CBG16342"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein CBG16342"/>
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        <property type="entry name" value="serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="MIP22305P"/>
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    </dbReference>
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        <property type="entry name" value="PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED"/>
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    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21161">
        <property type="entry name" value="P2R3B_EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD63412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F43B10.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q17744"/>
        </source>
    </evidence>
    <sequence length="557" mass="63214" checksum="C28FBC29874ED5C5" modified="2004-10-11" version="4"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>Q17782</accession>
    <name>Q17782_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="3 5" type="primary">bath-44</name>
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    <organism evidence="3 4">
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            <taxon>Rhabditidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
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    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD63529.1"/>
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        <property type="nucleotide sequence ID" value="NM_063149.5"/>
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    </dbReference>
    <dbReference type="GeneID" id="174210"/>
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    <dbReference type="AGR" id="WB:WBGene00015567"/>
    <dbReference type="CTD" id="174210"/>
    <dbReference type="WormBase" id="C07D10.2a">
        <property type="protein sequence ID" value="CE27057"/>
        <property type="gene ID" value="WBGene00015567"/>
        <property type="gene designation" value="bath-44"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004253_2_0_1"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015567">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q17782">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000038">
        <property type="entry name" value="BTB and MATH domain containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000025">
        <property type="entry name" value="BTB and MATH domain containing"/>
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        <property type="entry name" value="BTB and MATH domain containing"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.25.40.420">
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    <sequence length="390" mass="43861" checksum="E36FCB03526B3268" modified="2001-06-01" version="2">MDNSLMQMRHAADSWSTSEVRSLVHKHMWTIRGFSQLECRYLETSAKIKDITVPLTHQPSSSGGLPELPDITFRIRLHPQGNKESNKDFTFFQCFTNQATTTTTPTFRAKFKFTVFNQRTEETPTTVYSGTQQLHGYFEYIRREVLVGHVQPADDLILCLTITITFDTVTKAAQNTRSVPPELPMPSDVTKDLENLYRSGKHADFTLVVEERELKAHKAILAARSPVFAAMMEPHTAEAQNSRAILRDIDYEVVQAILYYIYTGTCTNMGGNALDILAAAERFALPGLKNIAEVAMRNGLATETVCKNLAFAEMYGLVDFKKEAIKYICMNANAVINSEGFLRLSRQNPDLIVDIMTVLVNERHNSPSCFSLDGTLEPASKRARMTETNL</sequence>
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        <interactant intactId="EBI-316320">
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</entry>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        </source>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD61396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C07G1.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="Q17795"/>
        </source>
    </evidence>
    <sequence length="607" mass="65108" checksum="D76CCF399BAA1CBF" modified="2003-03-01" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1999-07-15" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q19157-2</accession>
    <name>PIN2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of LIM domain-containing protein pin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">pin-2</name>
        <name type="ORF">F07C6.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1999" name="J. Cell Biol." volume="144" first="45" last="57">
            <title>A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hobert O."/>
                <person name="Moerman D.G."/>
                <person name="Clark K.A."/>
                <person name="Beckerle M.C."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="9885243"/>
            <dbReference type="DOI" id="10.1083/jcb.144.1.45"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19157-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q19157-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_044155"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255673.1">
        <property type="nucleotide sequence ID" value="NM_001268744.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F07C6.1b">
        <property type="protein sequence ID" value="CE47192"/>
        <property type="gene ID" value="WBGene00004030"/>
        <property type="gene designation" value="pin-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="56" mass="6560" checksum="E5BFE08B01ED16DF" modified="2012-10-03" version="2">MVHVFGKAFCPECYRCRGCDKVLHYKDKVMELDLMPLCKKCLGNKTFQKALKYKSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q19958-2</accession>
    <name>STO2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Stomatin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sto-2</name>
        <name type="ORF">F32A6.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Curr. Biol." volume="15" first="935" last="941">
            <title>Functional genomics of the cilium, a sensory organelle.</title>
            <authorList>
                <person name="Blacque O.E."/>
                <person name="Perens E.A."/>
                <person name="Boroevich K.A."/>
                <person name="Inglis P.N."/>
                <person name="Li C."/>
                <person name="Warner A."/>
                <person name="Khattra J."/>
                <person name="Holt R.A."/>
                <person name="Ou G."/>
                <person name="Mah A.K."/>
                <person name="McKay S.J."/>
                <person name="Huang P."/>
                <person name="Swoboda P."/>
                <person name="Jones S.J.M."/>
                <person name="Marra M.A."/>
                <person name="Baillie D.L."/>
                <person name="Moerman D.G."/>
                <person name="Shaham S."/>
                <person name="Leroux M.R."/>
            </authorList>
            <dbReference type="PubMed" id="15916950"/>
            <dbReference type="DOI" id="10.1016/j.cub.2005.04.059"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19958-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_039802 VSP_039801"/>
        </isoform>
        <isoform>
            <id>Q19958-1</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q19958-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_039799"/>
        </isoform>
        <isoform>
            <id>Q19958-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_039800 VSP_039803"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001257023.1">
        <property type="nucleotide sequence ID" value="NM_001270094.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F32A6.5a">
        <property type="protein sequence ID" value="CE43778"/>
        <property type="gene ID" value="WBGene00006064"/>
        <property type="gene designation" value="sto-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="320" mass="35731" checksum="BD5EEA53CB42CC3C" modified="2010-10-05" version="4">MESDDEGNIQIPVPTGQPRGRMGRRFTLNPLIFAKEEREARRQSLAQLKLSYYPKHMNPEHYDTGLGFCGWFLMGLSWIMVISTFPVSIYFCMKVVQEYERAVIFRLGRLIGGGAKGPGIFFVLPCIESYTKVDLRTVSFSVPPQEILTKDSVTTSVDAVIYYRISNATVSVANVENAHHSTRLLAQTTLRNMLGTRSLSEILSDRETLAASMQTILDEATESWGIKVERVEIKDVRLPIQLQRAMAAEAEATREARAKVIAAEGEQKASRALRDAASVIAQSPAALQLRYLQTLNSVAAEKNSTIIFPLPMELVRHLIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q19958-3</accession>
    <name>STO2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Stomatin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sto-2</name>
        <name type="ORF">F32A6.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Curr. Biol." volume="15" first="935" last="941">
            <title>Functional genomics of the cilium, a sensory organelle.</title>
            <authorList>
                <person name="Blacque O.E."/>
                <person name="Perens E.A."/>
                <person name="Boroevich K.A."/>
                <person name="Inglis P.N."/>
                <person name="Li C."/>
                <person name="Warner A."/>
                <person name="Khattra J."/>
                <person name="Holt R.A."/>
                <person name="Ou G."/>
                <person name="Mah A.K."/>
                <person name="McKay S.J."/>
                <person name="Huang P."/>
                <person name="Swoboda P."/>
                <person name="Jones S.J.M."/>
                <person name="Marra M.A."/>
                <person name="Baillie D.L."/>
                <person name="Moerman D.G."/>
                <person name="Shaham S."/>
                <person name="Leroux M.R."/>
            </authorList>
            <dbReference type="PubMed" id="15916950"/>
            <dbReference type="DOI" id="10.1016/j.cub.2005.04.059"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19958-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_039800 VSP_039803"/>
        </isoform>
        <isoform>
            <id>Q19958-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_039801 VSP_039802"/>
        </isoform>
        <isoform>
            <id>Q19958-1</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q19958-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_039799"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001257020.1">
        <property type="nucleotide sequence ID" value="NM_001270091.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F32A6.5b">
        <property type="protein sequence ID" value="CE44788"/>
        <property type="gene ID" value="WBGene00006064"/>
        <property type="gene designation" value="sto-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="358" mass="39605" checksum="268651F31C88428A" modified="2010-10-05" version="4">MSKSEGSRKVKLRFAASGVSSSNGGDSGDSSSNESERLMESDDEGNIQIPVPTGQPRGRMGRRFTLNPLIFAKEEREARRQSLAQLKLSYYPKHMNPEHYDTGLGFCGWFLMGLSWIMVISTFPVSIYFCMKVVQEYERAVIFRLGRLIGGGAKGPGIFFVLPCIESYTKVDLRTVSFSVPPQEILTKDSVTTSVDAVIYYRISNATVSVANVENAHHSTRLLAQTTLRNMLGTRSLSEILSDRETLAASMQTILDEATESWGIKVERVEIKDVRLPIQLQRAMAAEAEATREARAKVIAAEGEQKASRALRDAASVIAQSPAALQLRYLQTLNSVAAEKNSTIIFPLPMELVRHLIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q19958-4</accession>
    <name>STO2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform d of Stomatin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sto-2</name>
        <name type="ORF">F32A6.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Curr. Biol." volume="15" first="935" last="941">
            <title>Functional genomics of the cilium, a sensory organelle.</title>
            <authorList>
                <person name="Blacque O.E."/>
                <person name="Perens E.A."/>
                <person name="Boroevich K.A."/>
                <person name="Inglis P.N."/>
                <person name="Li C."/>
                <person name="Warner A."/>
                <person name="Khattra J."/>
                <person name="Holt R.A."/>
                <person name="Ou G."/>
                <person name="Mah A.K."/>
                <person name="McKay S.J."/>
                <person name="Huang P."/>
                <person name="Swoboda P."/>
                <person name="Jones S.J.M."/>
                <person name="Marra M.A."/>
                <person name="Baillie D.L."/>
                <person name="Moerman D.G."/>
                <person name="Shaham S."/>
                <person name="Leroux M.R."/>
            </authorList>
            <dbReference type="PubMed" id="15916950"/>
            <dbReference type="DOI" id="10.1016/j.cub.2005.04.059"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19958-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_039799"/>
        </isoform>
        <isoform>
            <id>Q19958-1</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q19958-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_039802 VSP_039801"/>
        </isoform>
        <isoform>
            <id>Q19958-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_039800 VSP_039803"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001257022.1">
        <property type="nucleotide sequence ID" value="NM_001270093.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F32A6.5d">
        <property type="protein sequence ID" value="CE44767"/>
        <property type="gene ID" value="WBGene00006064"/>
        <property type="gene designation" value="sto-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="347" mass="38598" checksum="8D41118167CACBC6" modified="2010-10-05" version="4">MEFLEVRQGSPNGGDSGDSSSNESERLMESDDEGNIQIPVPTGQPRGRMGRRFTLNPLIFAKEEREARRQSLAQLKLSYYPKHMNPEHYDTGLGFCGWFLMGLSWIMVISTFPVSIYFCMKVVQEYERAVIFRLGRLIGGGAKGPGIFFVLPCIESYTKVDLRTVSFSVPPQEILTKDSVTTSVDAVIYYRISNATVSVANVENAHHSTRLLAQTTLRNMLGTRSLSEILSDRETLAASMQTILDEATESWGIKVERVEIKDVRLPIQLQRAMAAEAEATREARAKVIAAEGEQKASRALRDAASVIAQSPAALQLRYLQTLNSVAAEKNSTIIFPLPMELVRHLIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q23444-2</accession>
    <name>RFT1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein RFT1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfth-1</name>
        <name evidence="2" type="ORF">ZK180.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q23444-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q23444-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_029511"/>
        </isoform>
        <isoform>
            <id>Q23444-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_053991"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367982.1">
        <property type="nucleotide sequence ID" value="NM_001380194.1"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK180.3b">
        <property type="protein sequence ID" value="CE48802"/>
        <property type="gene ID" value="WBGene00022677"/>
        <property type="gene designation" value="rfth-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q96AA3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="ZK180.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK180.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK180.3c"/>
        </source>
    </evidence>
    <sequence length="374" mass="41613" checksum="052EF04B3EAEF09F" modified="1996-11-01" version="1">MLICVKRIFVLAGLFMFPGMYHLELFAYAQYIGAIAYLLFNFVAFYIYIRNKSIPELEQFSTFSDLFPKFSEGIDRDSIHAVFTMFSHSILKQLLTDGSAYVMTFTELLSLKDQAVYDAVERVGSIIVRTILSPIDENCNAYFSNTIRKESSVFNKNTDNHDDLVDTLSKVLHVVGVIGFVACTFGIPYSPVVISLYGGKLLSENGGALLLSLYSGYILVTAINGITEGFAMASMDNRQIFTHGKFLFVTSIIHLIINYVLCVYMNSAGFIVANIINMSVRIIYNWRTIREYLGDKCPSFTEVLPTGQTSIFLGVSLLATSFTYLLFATTPGLSYTLAHIAIGAVCLILTAQDTAQHDSVFTVIVDSLAKKHRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q23444-3</accession>
    <name>RFT1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein RFT1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfth-1</name>
        <name evidence="2" type="ORF">ZK180.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q23444-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_053991"/>
        </isoform>
        <isoform>
            <id>Q23444-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_029511"/>
        </isoform>
        <isoform>
            <id>Q23444-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001368266.1">
        <property type="nucleotide sequence ID" value="NM_001380195.1"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK180.3c">
        <property type="protein sequence ID" value="CE48641"/>
        <property type="gene ID" value="WBGene00022677"/>
        <property type="gene designation" value="rfth-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q96AA3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="ZK180.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK180.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK180.3c"/>
        </source>
    </evidence>
    <sequence length="143" mass="15912" checksum="A5FC0917069DE813" modified="1996-11-01" version="1">MASMDNRQIFTHGKFLFVTSIIHLIINYVLCVYMNSAGFIVANIINMSVRIIYNWRTIREYLGDKCPSFTEVLPTGQTSIFLGVSLLATSFTYLLFATTPGLSYTLAHIAIGAVCLILTAQDTAQHDSVFTVIVDSLAKKHRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-02-08" modified="2026-01-28" version="201" xmlns="https://uniprot.org/uniprot">
    <accession>Q23551-2</accession>
    <name>UNC22_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isoform a of Twitchin</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Uncoordinated protein 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">unc-22</name>
        <name type="ORF">ZK617.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="1980" name="Dev. Biol." volume="77" first="271" last="302">
            <title>Mutants with altered muscle structure of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Waterston R.H."/>
                <person name="Thomson J.N."/>
                <person name="Brenner S."/>
            </authorList>
            <dbReference type="PubMed" id="7190524"/>
            <dbReference type="DOI" id="10.1016/0012-1606(80)90475-3"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="1988" name="Genes Dev." volume="2" first="93" last="105">
            <title>Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Moerman D.G."/>
                <person name="Benian G.M."/>
                <person name="Barstead R.J."/>
                <person name="Schriefer L.A."/>
                <person name="Waterston R.H."/>
            </authorList>
            <dbReference type="PubMed" id="2833427"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="1989" name="Nature" volume="342" first="45" last="50">
            <title>Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="Kiff J.E."/>
                <person name="Neckelmann N."/>
                <person name="Moerman D.G."/>
                <person name="Waterston R.H."/>
            </authorList>
            <dbReference type="PubMed" id="2812002"/>
            <dbReference type="DOI" id="10.1038/342045a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="1993" name="Genetics" volume="134" first="1097" last="1104">
            <title>Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="L'Hernault S.W."/>
                <person name="Morris M.E."/>
            </authorList>
            <dbReference type="PubMed" id="8397135"/>
        </citation>
        <scope>SEQUENCE REVISION TO N-TERMINUS</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1994" name="Nature" volume="369" first="581" last="584">
            <title>Insights into autoregulation from the crystal structure of twitchin kinase.</title>
            <authorList>
                <person name="Hu S.H."/>
                <person name="Parker M.W."/>
                <person name="Lei J.Y."/>
                <person name="Wilce M.C."/>
                <person name="Benian G.M."/>
                <person name="Kemp B.E."/>
            </authorList>
            <dbReference type="PubMed" id="8202162"/>
            <dbReference type="DOI" id="10.1038/369581a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 6211-6699</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>REGION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1996" name="J. Mol. Biol." volume="264" first="624" last="639">
            <title>Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Fong S."/>
                <person name="Hamill S.J."/>
                <person name="Proctor M."/>
                <person name="Freund S.M."/>
                <person name="Benian G.M."/>
                <person name="Chothia C."/>
                <person name="Bycroft M."/>
                <person name="Clarke J."/>
            </authorList>
            <dbReference type="PubMed" id="8969309"/>
            <dbReference type="DOI" id="10.1006/jmbi.1996.0665"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 4148-4240</scope>
    </reference>
    <reference evidence="7 9" key="7">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="9">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="journal article" date="2006" name="Mutat. Res." volume="601" first="19" last="29">
            <title>A mutational analysis of Caenorhabditis elegans in space.</title>
            <authorList>
                <person name="Zhao Y."/>
                <person name="Lai K."/>
                <person name="Cheung I."/>
                <person name="Youds J."/>
                <person name="Tarailo M."/>
                <person name="Tarailo S."/>
                <person name="Rose A."/>
            </authorList>
            <dbReference type="PubMed" id="16765996"/>
            <dbReference type="DOI" id="10.1016/j.mrfmmm.2006.05.001"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="7" key="9">
        <citation type="journal article" date="2008" name="Biophys. J." volume="95" first="1360" last="1370">
            <title>Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.</title>
            <authorList>
                <person name="Greene D.N."/>
                <person name="Garcia T."/>
                <person name="Sutton R.B."/>
                <person name="Gernert K.M."/>
                <person name="Benian G.M."/>
                <person name="Oberhauser A.F."/>
            </authorList>
            <dbReference type="PubMed" id="18390597"/>
            <dbReference type="DOI" id="10.1529/biophysj.108.130237"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2015" name="Mol. Biol. Cell" volume="26" first="2096" last="2111">
            <title>Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.</title>
            <authorList>
                <person name="Matsunaga Y."/>
                <person name="Qadota H."/>
                <person name="Furukawa M."/>
                <person name="Choe H.H."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="25851606"/>
            <dbReference type="DOI" id="10.1091/mbc.E14-05-1009"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MAK-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>PHOSPHORYLATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q23551-4</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_040608 VSP_040611"/>
        </isoform>
        <isoform>
            <id>Q23551-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_040607 VSP_040606"/>
        </isoform>
        <isoform>
            <id>Q23551-5</id>
            <name evidence="4">e</name>
            <sequence type="described" ref="VSP_040611 VSP_040605"/>
        </isoform>
        <isoform>
            <id>Q23551-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q23551-2</id>
            <name evidence="2 3 4">a</name>
            <sequence type="described" ref="VSP_040609 VSP_040611"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_502273.2">
        <property type="nucleotide sequence ID" value="NM_069872.5"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK617.1a">
        <property type="protein sequence ID" value="CE33017"/>
        <property type="gene ID" value="WBGene00006759"/>
        <property type="gene designation" value="unc-22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18390597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="2812002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="8397135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="2812002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="7190524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="CAA33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="EMBL" id="CAA98065.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="ZK617.1b"/>
        </source>
    </evidence>
    <sequence length="6839" mass="753500" checksum="0C911B40FAB7C7E9" modified="2003-06-01" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-02-08" modified="2026-01-28" version="201" xmlns="https://uniprot.org/uniprot">
    <accession>Q23551-3</accession>
    <name>UNC22_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isoform c of Twitchin</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Uncoordinated protein 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">unc-22</name>
        <name type="ORF">ZK617.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="1980" name="Dev. Biol." volume="77" first="271" last="302">
            <title>Mutants with altered muscle structure of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Waterston R.H."/>
                <person name="Thomson J.N."/>
                <person name="Brenner S."/>
            </authorList>
            <dbReference type="PubMed" id="7190524"/>
            <dbReference type="DOI" id="10.1016/0012-1606(80)90475-3"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="1988" name="Genes Dev." volume="2" first="93" last="105">
            <title>Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Moerman D.G."/>
                <person name="Benian G.M."/>
                <person name="Barstead R.J."/>
                <person name="Schriefer L.A."/>
                <person name="Waterston R.H."/>
            </authorList>
            <dbReference type="PubMed" id="2833427"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="1989" name="Nature" volume="342" first="45" last="50">
            <title>Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="Kiff J.E."/>
                <person name="Neckelmann N."/>
                <person name="Moerman D.G."/>
                <person name="Waterston R.H."/>
            </authorList>
            <dbReference type="PubMed" id="2812002"/>
            <dbReference type="DOI" id="10.1038/342045a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="1993" name="Genetics" volume="134" first="1097" last="1104">
            <title>Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="L'Hernault S.W."/>
                <person name="Morris M.E."/>
            </authorList>
            <dbReference type="PubMed" id="8397135"/>
        </citation>
        <scope>SEQUENCE REVISION TO N-TERMINUS</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1994" name="Nature" volume="369" first="581" last="584">
            <title>Insights into autoregulation from the crystal structure of twitchin kinase.</title>
            <authorList>
                <person name="Hu S.H."/>
                <person name="Parker M.W."/>
                <person name="Lei J.Y."/>
                <person name="Wilce M.C."/>
                <person name="Benian G.M."/>
                <person name="Kemp B.E."/>
            </authorList>
            <dbReference type="PubMed" id="8202162"/>
            <dbReference type="DOI" id="10.1038/369581a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 6211-6699</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>REGION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1996" name="J. Mol. Biol." volume="264" first="624" last="639">
            <title>Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Fong S."/>
                <person name="Hamill S.J."/>
                <person name="Proctor M."/>
                <person name="Freund S.M."/>
                <person name="Benian G.M."/>
                <person name="Chothia C."/>
                <person name="Bycroft M."/>
                <person name="Clarke J."/>
            </authorList>
            <dbReference type="PubMed" id="8969309"/>
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        <scope>STRUCTURE BY NMR OF 4148-4240</scope>
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    <reference evidence="7 9" key="7">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="9">Bristol N2</strain>
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    </reference>
    <reference evidence="7" key="8">
        <citation type="journal article" date="2006" name="Mutat. Res." volume="601" first="19" last="29">
            <title>A mutational analysis of Caenorhabditis elegans in space.</title>
            <authorList>
                <person name="Zhao Y."/>
                <person name="Lai K."/>
                <person name="Cheung I."/>
                <person name="Youds J."/>
                <person name="Tarailo M."/>
                <person name="Tarailo S."/>
                <person name="Rose A."/>
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            <dbReference type="DOI" id="10.1016/j.mrfmmm.2006.05.001"/>
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    <reference evidence="7" key="9">
        <citation type="journal article" date="2008" name="Biophys. J." volume="95" first="1360" last="1370">
            <title>Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.</title>
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                <person name="Greene D.N."/>
                <person name="Garcia T."/>
                <person name="Sutton R.B."/>
                <person name="Gernert K.M."/>
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        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
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                <person name="Matsunaga Y."/>
                <person name="Qadota H."/>
                <person name="Furukawa M."/>
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        <scope>INTERACTION WITH MAK-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>PHOSPHORYLATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="1980" name="Dev. Biol." volume="77" first="271" last="302">
            <title>Mutants with altered muscle structure of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Waterston R.H."/>
                <person name="Thomson J.N."/>
                <person name="Brenner S."/>
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            <dbReference type="DOI" id="10.1016/0012-1606(80)90475-3"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="1988" name="Genes Dev." volume="2" first="93" last="105">
            <title>Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Moerman D.G."/>
                <person name="Benian G.M."/>
                <person name="Barstead R.J."/>
                <person name="Schriefer L.A."/>
                <person name="Waterston R.H."/>
            </authorList>
            <dbReference type="PubMed" id="2833427"/>
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        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="1989" name="Nature" volume="342" first="45" last="50">
            <title>Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="Kiff J.E."/>
                <person name="Neckelmann N."/>
                <person name="Moerman D.G."/>
                <person name="Waterston R.H."/>
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            <dbReference type="PubMed" id="2812002"/>
            <dbReference type="DOI" id="10.1038/342045a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
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    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="1993" name="Genetics" volume="134" first="1097" last="1104">
            <title>Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="L'Hernault S.W."/>
                <person name="Morris M.E."/>
            </authorList>
            <dbReference type="PubMed" id="8397135"/>
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        <scope>SEQUENCE REVISION TO N-TERMINUS</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
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    </reference>
    <reference key="5">
        <citation type="journal article" date="1994" name="Nature" volume="369" first="581" last="584">
            <title>Insights into autoregulation from the crystal structure of twitchin kinase.</title>
            <authorList>
                <person name="Hu S.H."/>
                <person name="Parker M.W."/>
                <person name="Lei J.Y."/>
                <person name="Wilce M.C."/>
                <person name="Benian G.M."/>
                <person name="Kemp B.E."/>
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            <dbReference type="PubMed" id="8202162"/>
            <dbReference type="DOI" id="10.1038/369581a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 6211-6699</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>REGION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1996" name="J. Mol. Biol." volume="264" first="624" last="639">
            <title>Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans.</title>
            <authorList>
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                <person name="Hamill S.J."/>
                <person name="Proctor M."/>
                <person name="Freund S.M."/>
                <person name="Benian G.M."/>
                <person name="Chothia C."/>
                <person name="Bycroft M."/>
                <person name="Clarke J."/>
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            <dbReference type="PubMed" id="8969309"/>
            <dbReference type="DOI" id="10.1006/jmbi.1996.0665"/>
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        <scope>STRUCTURE BY NMR OF 4148-4240</scope>
    </reference>
    <reference evidence="7 9" key="7">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="9">Bristol N2</strain>
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    </reference>
    <reference evidence="7" key="8">
        <citation type="journal article" date="2006" name="Mutat. Res." volume="601" first="19" last="29">
            <title>A mutational analysis of Caenorhabditis elegans in space.</title>
            <authorList>
                <person name="Zhao Y."/>
                <person name="Lai K."/>
                <person name="Cheung I."/>
                <person name="Youds J."/>
                <person name="Tarailo M."/>
                <person name="Tarailo S."/>
                <person name="Rose A."/>
            </authorList>
            <dbReference type="PubMed" id="16765996"/>
            <dbReference type="DOI" id="10.1016/j.mrfmmm.2006.05.001"/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="7" key="9">
        <citation type="journal article" date="2008" name="Biophys. J." volume="95" first="1360" last="1370">
            <title>Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.</title>
            <authorList>
                <person name="Greene D.N."/>
                <person name="Garcia T."/>
                <person name="Sutton R.B."/>
                <person name="Gernert K.M."/>
                <person name="Benian G.M."/>
                <person name="Oberhauser A.F."/>
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            <dbReference type="PubMed" id="18390597"/>
            <dbReference type="DOI" id="10.1529/biophysj.108.130237"/>
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        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
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    <reference key="10">
        <citation type="journal article" date="2015" name="Mol. Biol. Cell" volume="26" first="2096" last="2111">
            <title>Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.</title>
            <authorList>
                <person name="Matsunaga Y."/>
                <person name="Qadota H."/>
                <person name="Furukawa M."/>
                <person name="Choe H.H."/>
                <person name="Benian G.M."/>
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            <dbReference type="DOI" id="10.1091/mbc.E14-05-1009"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MAK-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>PHOSPHORYLATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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        <citation type="journal article" date="1980" name="Dev. Biol." volume="77" first="271" last="302">
            <title>Mutants with altered muscle structure of Caenorhabditis elegans.</title>
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                <person name="Thomson J.N."/>
                <person name="Brenner S."/>
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            <dbReference type="DOI" id="10.1016/0012-1606(80)90475-3"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="1988" name="Genes Dev." volume="2" first="93" last="105">
            <title>Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Moerman D.G."/>
                <person name="Benian G.M."/>
                <person name="Barstead R.J."/>
                <person name="Schriefer L.A."/>
                <person name="Waterston R.H."/>
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            <dbReference type="PubMed" id="2833427"/>
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    <reference evidence="8" key="3">
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            <title>Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans.</title>
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                <person name="Benian G.M."/>
                <person name="Kiff J.E."/>
                <person name="Neckelmann N."/>
                <person name="Moerman D.G."/>
                <person name="Waterston R.H."/>
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            <dbReference type="PubMed" id="2812002"/>
            <dbReference type="DOI" id="10.1038/342045a0"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
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            <strain evidence="8">Bristol N2</strain>
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    <reference evidence="7" key="4">
        <citation type="journal article" date="1993" name="Genetics" volume="134" first="1097" last="1104">
            <title>Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Benian G.M."/>
                <person name="L'Hernault S.W."/>
                <person name="Morris M.E."/>
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            <dbReference type="PubMed" id="8397135"/>
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        <scope>SEQUENCE REVISION TO N-TERMINUS</scope>
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            <strain evidence="3">Bristol N2</strain>
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    <reference key="5">
        <citation type="journal article" date="1994" name="Nature" volume="369" first="581" last="584">
            <title>Insights into autoregulation from the crystal structure of twitchin kinase.</title>
            <authorList>
                <person name="Hu S.H."/>
                <person name="Parker M.W."/>
                <person name="Lei J.Y."/>
                <person name="Wilce M.C."/>
                <person name="Benian G.M."/>
                <person name="Kemp B.E."/>
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            <dbReference type="DOI" id="10.1038/369581a0"/>
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        <scope>REGION</scope>
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    <reference key="6">
        <citation type="journal article" date="1996" name="J. Mol. Biol." volume="264" first="624" last="639">
            <title>Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans.</title>
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                <person name="Fong S."/>
                <person name="Hamill S.J."/>
                <person name="Proctor M."/>
                <person name="Freund S.M."/>
                <person name="Benian G.M."/>
                <person name="Chothia C."/>
                <person name="Bycroft M."/>
                <person name="Clarke J."/>
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            <dbReference type="PubMed" id="8969309"/>
            <dbReference type="DOI" id="10.1006/jmbi.1996.0665"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 4148-4240</scope>
    </reference>
    <reference evidence="7 9" key="7">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="9">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="journal article" date="2006" name="Mutat. Res." volume="601" first="19" last="29">
            <title>A mutational analysis of Caenorhabditis elegans in space.</title>
            <authorList>
                <person name="Zhao Y."/>
                <person name="Lai K."/>
                <person name="Cheung I."/>
                <person name="Youds J."/>
                <person name="Tarailo M."/>
                <person name="Tarailo S."/>
                <person name="Rose A."/>
            </authorList>
            <dbReference type="PubMed" id="16765996"/>
            <dbReference type="DOI" id="10.1016/j.mrfmmm.2006.05.001"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="7" key="9">
        <citation type="journal article" date="2008" name="Biophys. J." volume="95" first="1360" last="1370">
            <title>Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.</title>
            <authorList>
                <person name="Greene D.N."/>
                <person name="Garcia T."/>
                <person name="Sutton R.B."/>
                <person name="Gernert K.M."/>
                <person name="Benian G.M."/>
                <person name="Oberhauser A.F."/>
            </authorList>
            <dbReference type="PubMed" id="18390597"/>
            <dbReference type="DOI" id="10.1529/biophysj.108.130237"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2015" name="Mol. Biol. Cell" volume="26" first="2096" last="2111">
            <title>Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.</title>
            <authorList>
                <person name="Matsunaga Y."/>
                <person name="Qadota H."/>
                <person name="Furukawa M."/>
                <person name="Choe H.H."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="25851606"/>
            <dbReference type="DOI" id="10.1091/mbc.E14-05-1009"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MAK-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>PHOSPHORYLATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q23551-5</id>
            <name evidence="4">e</name>
            <sequence type="described" ref="VSP_040611 VSP_040605"/>
        </isoform>
        <isoform>
            <id>Q23551-3</id>
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            <sequence type="described" ref="VSP_040607 VSP_040606"/>
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        <isoform>
            <id>Q23551-4</id>
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        </isoform>
        <isoform>
            <id>Q23551-1</id>
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            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q23551-2</id>
            <name evidence="2 3 4">a</name>
            <sequence type="described" ref="VSP_040609 VSP_040611"/>
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    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
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        <property type="component" value="Chromosome IV"/>
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    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18390597"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="9851916"/>
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    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="2812002"/>
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    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="7190524"/>
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    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="CAA33463.1"/>
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    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="EMBL" id="CAA98065.2"/>
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    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="ZK617.1b"/>
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    <accession>Q65XX7-2</accession>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2003" name="Development" volume="130" first="2881" last="2892">
            <title>The C. elegans Hand gene controls embryogenesis and early gonadogenesis.</title>
            <authorList>
                <person name="Mathies L.D."/>
                <person name="Henderson S.T."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="12756172"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ARG-41</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2004" name="Development" volume="131" first="4333" last="4343">
            <title>TRA-1/GLI controls development of somatic gonadal precursors in C. elegans.</title>
            <authorList>
                <person name="Mathies L.D."/>
                <person name="Schvarzstein M."/>
                <person name="Morphy K.M."/>
                <person name="Blelloch R."/>
                <person name="Spence A.M."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="15294864"/>
            <dbReference type="DOI" id="10.1242/dev.01288"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2010" name="Dev. Biol." volume="339" first="51" last="64">
            <title>hunchback and Ikaros-like zinc finger genes control reproductive system development in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Large E.E."/>
                <person name="Mathies L.D."/>
            </authorList>
            <dbReference type="PubMed" id="20026024"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2009.12.013"/>
        </citation>
        <scope>FUNCTION (ISOFORMS A AND B)</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2014" name="G3 (Bethesda)" volume="4" first="471" last="483">
            <title>Caenorhabditis elegans SWI/SNF subunits control sequential developmental stages in the somatic gonad.</title>
            <authorList>
                <person name="Large E.E."/>
                <person name="Mathies L.D."/>
            </authorList>
            <dbReference type="PubMed" id="24402584"/>
            <dbReference type="DOI" id="10.1534/g3.113.009852"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
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            <name evidence="5">c</name>
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            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK616.10a"/>
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    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK616.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK616.10c"/>
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    <accession>Q65XX7-3</accession>
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        <recommendedName>
            <fullName evidence="1">Isoform c of Zinc finger protein ehn-3</fullName>
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    <gene>
        <name evidence="3" type="primary">ehn-3</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2003" name="Development" volume="130" first="2881" last="2892">
            <title>The C. elegans Hand gene controls embryogenesis and early gonadogenesis.</title>
            <authorList>
                <person name="Mathies L.D."/>
                <person name="Henderson S.T."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="12756172"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ARG-41</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2004" name="Development" volume="131" first="4333" last="4343">
            <title>TRA-1/GLI controls development of somatic gonadal precursors in C. elegans.</title>
            <authorList>
                <person name="Mathies L.D."/>
                <person name="Schvarzstein M."/>
                <person name="Morphy K.M."/>
                <person name="Blelloch R."/>
                <person name="Spence A.M."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="15294864"/>
            <dbReference type="DOI" id="10.1242/dev.01288"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2010" name="Dev. Biol." volume="339" first="51" last="64">
            <title>hunchback and Ikaros-like zinc finger genes control reproductive system development in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Large E.E."/>
                <person name="Mathies L.D."/>
            </authorList>
            <dbReference type="PubMed" id="20026024"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2009.12.013"/>
        </citation>
        <scope>FUNCTION (ISOFORMS A AND B)</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2014" name="G3 (Bethesda)" volume="4" first="471" last="483">
            <title>Caenorhabditis elegans SWI/SNF subunits control sequential developmental stages in the somatic gonad.</title>
            <authorList>
                <person name="Large E.E."/>
                <person name="Mathies L.D."/>
            </authorList>
            <dbReference type="PubMed" id="24402584"/>
            <dbReference type="DOI" id="10.1534/g3.113.009852"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q65XX7-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060360"/>
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            <id>Q65XX7-3</id>
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            <sequence type="described" ref="VSP_060360 VSP_060361"/>
        </isoform>
        <isoform>
            <id>Q65XX7-1</id>
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            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001023617.1">
        <property type="nucleotide sequence ID" value="NM_001028446.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="CE37600"/>
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        <property type="component" value="Chromosome IV"/>
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    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
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    <name>Q7JL40_CAEEL</name>
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            <fullName evidence="5 15">Pyruvate kinase</fullName>
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    <gene>
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        <name evidence="18" type="ORF">CELE_F25H5.3</name>
        <name evidence="20" type="ORF">F25H5.3</name>
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    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
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    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
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    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
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    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="21" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14 18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
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            <begin position="47"/>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAE54896.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    <sequence length="531" mass="57401" checksum="A14B4169DDFEE02A" modified="2004-07-05" version="1"> </sequence>
</entry>
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            <taxon>Metazoa</taxon>
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            <taxon>Rhabditina</taxon>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
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        <property type="protein sequence ID" value="CE35914"/>
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        <property type="gene designation" value="ret-1"/>
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        <property type="entry name" value="RTN1-4"/>
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        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="38"/>
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            <end position="153"/>
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    <feature type="domain" description="Reticulon" evidence="7">
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            <end position="204"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004477"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAE48546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="W06A7.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q7JLB0"/>
        </source>
    </evidence>
    <sequence length="204" mass="22626" checksum="FE3B9B945165A274" modified="2004-07-05" version="1">MLSCQCQKVLDVIYWRDAKKSAIVLSLALLVLFVLAKYPLLTVVTYSLLLALGAAAGFRVFKKVEAQIKKTDSEHPFSEILAQDLTLPQEKVHAQADVFVEHATCIANKLKKLVFVESPLESIKFGLVLWSLTYIASWFSGFTLAILGLLGVFSVPKVYESNQEAIDPHLATISGHLKNVQNIIDEKLPFLRSAPVAAEEKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JLB1</accession>
    <name>Q7JLB1_CAEEL</name>
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        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">ret-1</name>
        <name evidence="9" type="ORF">CELE_W06A7.3</name>
        <name evidence="11" type="ORF">W06A7.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAE48544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379411.1">
        <property type="nucleotide sequence ID" value="NM_001392661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JLB1"/>
    <dbReference type="SMR" id="Q7JLB1"/>
    <dbReference type="PeptideAtlas" id="Q7JLB1"/>
    <dbReference type="GeneID" id="179981"/>
    <dbReference type="UCSC" id="W06A7.3b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004336"/>
    <dbReference type="CTD" id="179981"/>
    <dbReference type="WormBase" id="W06A7.3d">
        <property type="protein sequence ID" value="CE35913"/>
        <property type="gene ID" value="WBGene00004336"/>
        <property type="gene designation" value="ret-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478366_0_0_1"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="WormBase" id="K08G2.12b"/>
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</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QA6-10</accession>
    <name>PAT12_CAEEL</name>
    <protein>
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            <fullName evidence="2">Isoform j of Protein pat-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Paralyzed arrest at two-fold 12 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pat-12</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2011" name="Dev. Biol." volume="350" first="267" last="278">
            <title>PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.</title>
            <authorList>
                <person name="Hetherington S."/>
                <person name="Gally C."/>
                <person name="Fritz J.A."/>
                <person name="Polanowska J."/>
                <person name="Reboul J."/>
                <person name="Schwab Y."/>
                <person name="Zahreddine H."/>
                <person name="Behm C."/>
                <person name="Labouesse M."/>
            </authorList>
            <dbReference type="PubMed" id="21130760"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.11.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH VAB-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Hemidesmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Basal cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95QA6-5</id>
            <name evidence="8">e</name>
            <sequence type="described" ref="VSP_058361 VSP_058353 VSP_058359"/>
        </isoform>
        <isoform>
            <id>Q95QA6-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_058356"/>
        </isoform>
        <isoform>
            <id>Q95QA6-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_058360"/>
        </isoform>
        <isoform>
            <id>Q95QA6-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_058355"/>
        </isoform>
        <isoform>
            <id>Q95QA6-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_058352 VSP_058359"/>
        </isoform>
        <isoform>
            <id>Q95QA6-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_058358 VSP_058353 VSP_058361"/>
        </isoform>
        <isoform>
            <id>Q95QA6-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_058353 VSP_058361 VSP_058357"/>
        </isoform>
        <isoform>
            <id>Q95QA6-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_058357"/>
        </isoform>
        <isoform>
            <id>Q95QA6-11</id>
            <name evidence="13">k</name>
            <sequence type="described" ref="VSP_058354"/>
        </isoform>
        <isoform>
            <id>Q95QA6-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741076.1">
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    </dbReference>
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        <property type="protein sequence ID" value="CE31617"/>
        <property type="gene ID" value="WBGene00003936"/>
        <property type="gene designation" value="pat-12"/>
    </dbReference>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="T17H7.4a"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="T17H7.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T17H7.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T17H7.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T17H7.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T17H7.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="T17H7.4k"/>
        </source>
    </evidence>
    <sequence length="716" mass="82921" checksum="C3888625994AE39D" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QA6-11</accession>
    <name>PAT12_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform k of Protein pat-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Paralyzed arrest at two-fold 12 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pat-12</name>
        <name evidence="4" type="ORF">T17H7.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2011" name="Dev. Biol." volume="350" first="267" last="278">
            <title>PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.</title>
            <authorList>
                <person name="Hetherington S."/>
                <person name="Gally C."/>
                <person name="Fritz J.A."/>
                <person name="Polanowska J."/>
                <person name="Reboul J."/>
                <person name="Schwab Y."/>
                <person name="Zahreddine H."/>
                <person name="Behm C."/>
                <person name="Labouesse M."/>
            </authorList>
            <dbReference type="PubMed" id="21130760"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2010.11.025"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH VAB-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Hemidesmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <text evidence="1">Co-localizes with actin.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95QA6-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95QA6-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_058356"/>
        </isoform>
        <isoform>
            <id>Q95QA6-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_058360"/>
        </isoform>
        <isoform>
            <id>Q95QA6-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_058355"/>
        </isoform>
        <isoform>
            <id>Q95QA6-5</id>
            <name evidence="8">e</name>
            <sequence type="described" ref="VSP_058361 VSP_058359 VSP_058353"/>
        </isoform>
        <isoform>
            <id>Q95QA6-11</id>
            <name evidence="13">k</name>
            <sequence type="described" ref="VSP_058354"/>
        </isoform>
        <isoform>
            <id>Q95QA6-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_058357"/>
        </isoform>
        <isoform>
            <id>Q95QA6-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_058359 VSP_058352"/>
        </isoform>
        <isoform>
            <id>Q95QA6-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_058361 VSP_058358 VSP_058353"/>
        </isoform>
        <isoform>
            <id>Q95QA6-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_058357 VSP_058361 VSP_058353"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741077.1">
        <property type="nucleotide sequence ID" value="NM_171068.5"/>
    </dbReference>
    <dbReference type="WormBase" id="T17H7.4k">
        <property type="protein sequence ID" value="CE31618"/>
        <property type="gene ID" value="WBGene00003936"/>
        <property type="gene designation" value="pat-12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="21130760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T17H7.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T17H7.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T17H7.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="T17H7.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="T17H7.4e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="T17H7.4g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="T17H7.4h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="T17H7.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="T17H7.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="T17H7.4k"/>
        </source>
    </evidence>
    <sequence length="657" mass="76294" checksum="6B33DA15F9185B7A" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q9BI64</accession>
    <name>Q9BI64_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nrde-4</name>
        <name evidence="2" type="ORF">CELE_F45E4.10</name>
        <name evidence="4" type="ORF">F45E4.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD63786.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343615.1">
        <property type="nucleotide sequence ID" value="NM_001356928.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9BI64"/>
    <dbReference type="SMR" id="Q9BI64"/>
    <dbReference type="GeneID" id="177544"/>
    <dbReference type="UCSC" id="F45E4.10b.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001584"/>
    <dbReference type="CTD" id="177544"/>
    <dbReference type="WormBase" id="F45E4.10a">
        <property type="protein sequence ID" value="CE52211"/>
        <property type="gene ID" value="WBGene00001584"/>
        <property type="gene designation" value="nrde-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10630722at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001584">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9BI64">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63786.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F45E4.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q9BI64"/>
        </source>
    </evidence>
    <sequence length="780" mass="91417" checksum="7A06A76204415497" modified="2017-12-20" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2025-10-08" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q9BI72</accession>
    <name>Q9BI72_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ENTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">epn-1</name>
        <name evidence="9" type="ORF">CELE_T04C10.2</name>
        <name evidence="11" type="ORF">T04C10.2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAC35824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_510459.1">
        <property type="nucleotide sequence ID" value="NM_078058.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9BI72"/>
    <dbReference type="SMR" id="Q9BI72"/>
    <dbReference type="DIP" id="DIP-25420N"/>
    <dbReference type="PeptideAtlas" id="Q9BI72"/>
    <dbReference type="GeneID" id="181577"/>
    <dbReference type="UCSC" id="T04C10.2b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001329"/>
    <dbReference type="CTD" id="181577"/>
    <dbReference type="WormBase" id="T04C10.2a">
        <property type="protein sequence ID" value="CE26820"/>
        <property type="gene ID" value="WBGene00001329"/>
        <property type="gene designation" value="epn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001329">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9BI72">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16990">
        <property type="entry name" value="ENTH_Epsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000002">
        <property type="entry name" value="epsin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF115">
        <property type="entry name" value="FI19443P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC35824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="T04C10.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="Q9BI72"/>
        </source>
    </evidence>
    <sequence length="467" mass="50777" checksum="6E22FFE7733D7210" modified="2001-06-01" version="1">MSISTIRRQVKNVAYNFSDAQVKVREATSNDPWGPSTALMSEIADLTHNPMAFTEIMSIVWKRLNDSGKNWRHVYKSLVLLDFLIKCGHEKVAQQCRENVFTIETLKDFQHVEDNRDQGLNIREKAKQITSLLSDDERLKNERTRFILTRNKFKQNNPGPVGAESRRSNRHHVTDASLDPEYEDARPSTATEEEMQLQIALALSREECEKADEMRKSDDARLQMALEESQKDADRLATTKQGTVSSGQLTQSALDDLLSLGVGELVSGNNDQPSSSSAWGMNDPWGAPQASASLNTNDQMFANSMSNNDPWATSTVAQPVAATAPNSDPFASWDAPAPAATTPSTMPTSSSFDLLGGDLLSPTNSLSANINTNNSTNGTRKTPENFLGENSNLVNLDNLLGSGTPSTTGGNPFLTGAAPANANPFAAQQRKSPTLNEMRAAQGQAPPIPSMAPRGTLPQANPFANPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2026-01-28" version="176" xmlns="https://uniprot.org/uniprot">
    <accession>Q9BI73</accession>
    <name>Q9BI73_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">prps-1</name>
        <name evidence="14" type="ORF">CELE_R151.2</name>
        <name evidence="16" type="ORF">R151.2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. The active form is probably a hexamer composed of 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD70752.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367827.1">
        <property type="nucleotide sequence ID" value="NM_001379786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9BI73"/>
    <dbReference type="SMR" id="Q9BI73"/>
    <dbReference type="PeptideAtlas" id="Q9BI73"/>
    <dbReference type="GeneID" id="176016"/>
    <dbReference type="UCSC" id="R151.2d.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020107"/>
    <dbReference type="CTD" id="176016"/>
    <dbReference type="WormBase" id="R151.2b">
        <property type="protein sequence ID" value="CE48046"/>
        <property type="gene ID" value="WBGene00020107"/>
        <property type="gene designation" value="prps-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_3_0_1"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020107">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9BI73">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000011">
        <property type="entry name" value="Putative ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD70752.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="R151.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="Q9BI73"/>
        </source>
    </evidence>
    <sequence length="319" mass="34773" checksum="0D6C109A6BB0A485" modified="2013-02-06" version="3">MPNIKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIASSCRVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNWQTSVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADKVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDENMKKCSKIQCIDISMILAEAIRRTHNGESVSYLFSHVPIC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q9NAA7-2</accession>
    <name>NSUN5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform a of 26S rRNA (cytosine-C(5))-methyltransferase nsun-5</fullName>
            <ecNumber evidence="1 2 5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>5-methylcytosine rRNA methyltransferase nsun-5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NOL1/NOP2/Sun domain family member 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">RNA cytosine C(5)-methyltransferase nsun-5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">rRNA cytosine C(5)-methyltransferase nsun-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">nsun-5</name>
        <name evidence="7" type="ORF">Y53F4B.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="6158" last="6158">
            <title>Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.</title>
            <authorList>
                <person name="Schosserer M."/>
                <person name="Minois N."/>
                <person name="Angerer T.B."/>
                <person name="Amring M."/>
                <person name="Dellago H."/>
                <person name="Harreither E."/>
                <person name="Calle-Perez A."/>
                <person name="Pircher A."/>
                <person name="Gerstl M.P."/>
                <person name="Pfeifenberger S."/>
                <person name="Brandl C."/>
                <person name="Sonntagbauer M."/>
                <person name="Kriegner A."/>
                <person name="Linder A."/>
                <person name="Weinhaeusel A."/>
                <person name="Mohr T."/>
                <person name="Steiger M."/>
                <person name="Mattanovich D."/>
                <person name="Rinnerthaler M."/>
                <person name="Karl T."/>
                <person name="Sharma S."/>
                <person name="Entian K.D."/>
                <person name="Kos M."/>
                <person name="Breitenbach M."/>
                <person name="Wilson I.B."/>
                <person name="Polacek N."/>
                <person name="Grillari-Voglauer R."/>
                <person name="Breitenbach-Koller L."/>
                <person name="Grillari J."/>
            </authorList>
            <dbReference type="PubMed" id="25635753"/>
            <dbReference type="DOI" id="10.1038/ncomms7158"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2019" name="Cell. Physiol. Biochem." volume="52" first="970" last="983">
            <title>A Novel Caenorhabditis Elegans Proteinopathy Model Shows Changes in mRNA Translational Frameshifting During Aging.</title>
            <authorList>
                <person name="Adamla F."/>
                <person name="Rollins J."/>
                <person name="Newsom M."/>
                <person name="Snow S."/>
                <person name="Schosserer M."/>
                <person name="Heissenberger C."/>
                <person name="Horrocks J."/>
                <person name="Rogers A.N."/>
                <person name="Ignatova Z."/>
            </authorList>
            <dbReference type="PubMed" id="30977983"/>
            <dbReference type="DOI" id="10.33594/000000067"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Heissenberger C."/>
                <person name="Rollins J.A."/>
                <person name="Krammer T.L."/>
                <person name="Nagelreiter F."/>
                <person name="Stocker I."/>
                <person name="Wacheul L."/>
                <person name="Shpylovyi A."/>
                <person name="Tav K."/>
                <person name="Snow S."/>
                <person name="Grillari J."/>
                <person name="Rogers A.N."/>
                <person name="Lafontaine D.L."/>
                <person name="Schosserer M."/>
            </authorList>
            <dbReference type="PubMed" id="33289480"/>
            <dbReference type="DOI" id="10.7554/elife.56205"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2020" name="EMBO J." volume="0" first="0" last="0">
            <title>Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Navarro I.C."/>
                <person name="Tuorto F."/>
                <person name="Jordan D."/>
                <person name="Legrand C."/>
                <person name="Price J."/>
                <person name="Braukmann F."/>
                <person name="Hendrick A.G."/>
                <person name="Akay A."/>
                <person name="Kotter A."/>
                <person name="Helm M."/>
                <person name="Lyko F."/>
                <person name="Miska E.A."/>
            </authorList>
            <dbReference type="PubMed" id="33283887"/>
            <dbReference type="DOI" id="10.15252/embj.2020105496"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9NAA7-2</id>
            <name evidence="6">a</name>
            <sequence type="described" ref="VSP_060574"/>
        </isoform>
        <isoform>
            <id>Q9NAA7-1</id>
            <name evidence="7">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9NAA7-3</id>
            <name evidence="8">c</name>
            <sequence type="described" ref="VSP_060575"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1 2 5"/>
    <dbReference type="RefSeq" id="NP_001366973.1">
        <property type="nucleotide sequence ID" value="NM_001381672.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y53F4B.4a">
        <property type="protein sequence ID" value="CE39655"/>
        <property type="gene ID" value="WBGene00013151"/>
        <property type="gene designation" value="nsun-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="33283887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="33289480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="25635753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="25635753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y53F4B.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y53F4B.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y53F4B.4c"/>
        </source>
    </evidence>
    <sequence length="285" mass="32309" checksum="9B4F6336298BFD90" modified="2004-07-05" version="2">MKTLETEKWKILGTLKPENFAEMVTKMKDDEVYVDPHVENLIIFAPNIQNFYEYWMVEQRYLILQDKASCLPAFLLNPRPGSQVFDTCAAPGMKTSHAAAIMENQGKVWAMDRAADRVATMKQLLDASKVAIASSFCGDFLKTDVTDKKFSKVKFAIVDPPCSGSGIVKRMDEITGGNAEKERLEKLKNLQAMILKHALKLPGLKRAVYSTCSVHEEENEQVVDEVLLDTYVRQNYVLKKNVLPEWTYRGLKTYEVGEHCLRANPKVTLTNGFFVAVFERVKSSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q9NAA7-3</accession>
    <name>NSUN5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform c of 26S rRNA (cytosine-C(5))-methyltransferase nsun-5</fullName>
            <ecNumber evidence="1 2 5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>5-methylcytosine rRNA methyltransferase nsun-5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NOL1/NOP2/Sun domain family member 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">RNA cytosine C(5)-methyltransferase nsun-5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">rRNA cytosine C(5)-methyltransferase nsun-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">nsun-5</name>
        <name evidence="7" type="ORF">Y53F4B.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="6158" last="6158">
            <title>Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.</title>
            <authorList>
                <person name="Schosserer M."/>
                <person name="Minois N."/>
                <person name="Angerer T.B."/>
                <person name="Amring M."/>
                <person name="Dellago H."/>
                <person name="Harreither E."/>
                <person name="Calle-Perez A."/>
                <person name="Pircher A."/>
                <person name="Gerstl M.P."/>
                <person name="Pfeifenberger S."/>
                <person name="Brandl C."/>
                <person name="Sonntagbauer M."/>
                <person name="Kriegner A."/>
                <person name="Linder A."/>
                <person name="Weinhaeusel A."/>
                <person name="Mohr T."/>
                <person name="Steiger M."/>
                <person name="Mattanovich D."/>
                <person name="Rinnerthaler M."/>
                <person name="Karl T."/>
                <person name="Sharma S."/>
                <person name="Entian K.D."/>
                <person name="Kos M."/>
                <person name="Breitenbach M."/>
                <person name="Wilson I.B."/>
                <person name="Polacek N."/>
                <person name="Grillari-Voglauer R."/>
                <person name="Breitenbach-Koller L."/>
                <person name="Grillari J."/>
            </authorList>
            <dbReference type="PubMed" id="25635753"/>
            <dbReference type="DOI" id="10.1038/ncomms7158"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference key="3">
        <citation type="journal article" date="2019" name="Cell. Physiol. Biochem." volume="52" first="970" last="983">
            <title>A Novel Caenorhabditis Elegans Proteinopathy Model Shows Changes in mRNA Translational Frameshifting During Aging.</title>
            <authorList>
                <person name="Adamla F."/>
                <person name="Rollins J."/>
                <person name="Newsom M."/>
                <person name="Snow S."/>
                <person name="Schosserer M."/>
                <person name="Heissenberger C."/>
                <person name="Horrocks J."/>
                <person name="Rogers A.N."/>
                <person name="Ignatova Z."/>
            </authorList>
            <dbReference type="PubMed" id="30977983"/>
            <dbReference type="DOI" id="10.33594/000000067"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Heissenberger C."/>
                <person name="Rollins J.A."/>
                <person name="Krammer T.L."/>
                <person name="Nagelreiter F."/>
                <person name="Stocker I."/>
                <person name="Wacheul L."/>
                <person name="Shpylovyi A."/>
                <person name="Tav K."/>
                <person name="Snow S."/>
                <person name="Grillari J."/>
                <person name="Rogers A.N."/>
                <person name="Lafontaine D.L."/>
                <person name="Schosserer M."/>
            </authorList>
            <dbReference type="PubMed" id="33289480"/>
            <dbReference type="DOI" id="10.7554/elife.56205"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2020" name="EMBO J." volume="0" first="0" last="0">
            <title>Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Navarro I.C."/>
                <person name="Tuorto F."/>
                <person name="Jordan D."/>
                <person name="Legrand C."/>
                <person name="Price J."/>
                <person name="Braukmann F."/>
                <person name="Hendrick A.G."/>
                <person name="Akay A."/>
                <person name="Kotter A."/>
                <person name="Helm M."/>
                <person name="Lyko F."/>
                <person name="Miska E.A."/>
            </authorList>
            <dbReference type="PubMed" id="33283887"/>
            <dbReference type="DOI" id="10.15252/embj.2020105496"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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            <dbReference type="PubMed" id="33289480"/>
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    <sequence length="375" mass="42532" checksum="C487BE948D40CEE4" modified="2004-07-05" version="2">MKRDANIGGSVELLYVLMYETLVGSGLTRCSQELKSVISRRIQRIKEVEHAMQDEGRGIKAMKEADDGMKKIQIPRYARINTLKWTADEAMKTLETEKWKILGTLKPENFAEMVTKMKDDEVYVDPHVENLIIFAPNIQNFYEYWMVEQRYLILQDKASCLPAFLLNPRPGSQVFDTCAAPGMKTSHAAAIMENQGKVWAMDRAADRVATMKQLLDASKVAIASSFCGDFLKTDVTDKKFSKVKFAIVDPPCSGSGIVKRMDEITGGNAEKERLEKLKNLQAMILKHALKLPGLKRAVYSTCSVHEEENEQVVDEVLLDTYVRQNYVLKKNVLPEWTYRGLKTYEVGEHCLRANPKVTLTNGFFVAVFERVKSSE</sequence>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <strain evidence="7 8">Bristol N2</strain>
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    </dbReference>
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    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="68"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR32624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T05A1.1c"/>
        </source>
    </evidence>
    <sequence length="412" mass="47153" checksum="E385485D0D944C74" modified="2014-09-03" version="1">MLRQSDGTRMLQEMRRKLIQLHSSQMINETEETCDRYIDKHPDMTNEPTVLVTFSLLYLHIFLLGILGNSAVLYLTMKHRQLQTVQNIFILNLCASNVLMCLTSLPITFITNVYKQWFFSSPVCKLIPLVQGASIFVSTFSLSAIALDRYNLVVRPHKQKLSSRSAMMIALLIWVISVVVCMPYGWYMDVEKLNGLCGEYCSEHWPLAEVRKGYTFLVLITQFLFPFATMAFCYYNIFSRLRQRVETKLKKLSERSQLLENSTTCGTTNHIVSINAEAVQNGLENKQRLAVLAQQRRTTTILSCMVLLFAFTWLPHNVVTLMIEYDGFFFHSDETSATSTDHTYIVSMTAHLISMLTNVTNPFLYAWLNPMFKEMLIKTLRGGSKSPKPADIKQTSFIRMPNSGAPSQSSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AQS0</accession>
    <name>A0A0K3AQS0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGC-kinase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_W05F2.8</name>
        <name evidence="1 3" type="ORF">W05F2.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300445.1">
        <property type="nucleotide sequence ID" value="NM_001313516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AQS0"/>
    <dbReference type="GeneID" id="13179739"/>
    <dbReference type="AGR" id="WB:WBGene00195045"/>
    <dbReference type="CTD" id="13179739"/>
    <dbReference type="WormBase" id="W05F2.8b">
        <property type="protein sequence ID" value="CE50223"/>
        <property type="gene ID" value="WBGene00195045"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00195045">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AQS0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CTQ86384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="W05F2.8b"/>
        </source>
    </evidence>
    <sequence length="90" mass="10092" checksum="BDBD215B98E030F7" modified="2015-11-11" version="1">MQRRKESKISQDVEMTEAFDLQKMREFFPANGDLLSSFPQDFLEDSGDGEVHEAAILSVFDDNSNSPPPCPIVVDTVPDDDDSLLFPRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AQS4</accession>
    <name>A0A0K3AQS4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rhgf-3</name>
        <name evidence="8" type="ORF">CELE_Y105E8A.25</name>
        <name evidence="10" type="ORF">Y105E8A.25</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001313521.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AQS4"/>
    <dbReference type="SMR" id="A0A0K3AQS4"/>
    <dbReference type="PeptideAtlas" id="A0A0K3AQS4"/>
    <dbReference type="GeneID" id="3564893"/>
    <dbReference type="AGR" id="WB:WBGene00013682"/>
    <dbReference type="CTD" id="3564893"/>
    <dbReference type="WormBase" id="Y105E8A.25e">
        <property type="protein sequence ID" value="CE50227"/>
        <property type="gene ID" value="WBGene00013682"/>
        <property type="gene designation" value="rhgf-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28045at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013682">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AQS4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF21">
        <property type="entry name" value="CYSTS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="7">
        <location>
            <begin position="63"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="793"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="742"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="800"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CTQ86389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y105E8A.25e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AQS4"/>
        </source>
    </evidence>
    <sequence length="863" mass="96859" checksum="F24DE3C2C3B7D3DD" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AQS9</accession>
    <name>A0A0K3AQS9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Levamisole resistant protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lev-11</name>
        <name evidence="6" type="ORF">CELE_Y105E8B.1</name>
        <name evidence="8" type="ORF">Y105E8B.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300455.1">
        <property type="nucleotide sequence ID" value="NM_001313526.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AQS9"/>
    <dbReference type="SMR" id="A0A0K3AQS9"/>
    <dbReference type="PeptideAtlas" id="A0A0K3AQS9"/>
    <dbReference type="GeneID" id="173319"/>
    <dbReference type="AGR" id="WB:WBGene00002978"/>
    <dbReference type="CTD" id="173319"/>
    <dbReference type="WormBase" id="Y105E8B.1m">
        <property type="protein sequence ID" value="CE50134"/>
        <property type="gene ID" value="WBGene00002978"/>
        <property type="gene designation" value="lev-11"/>
    </dbReference>
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            <begin position="1"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="EMBL" id="CTQ86394.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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        <source>
            <dbReference type="WormBase" id="Y105E8B.1m"/>
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    <evidence type="ECO:0007829" key="9">
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            <dbReference type="PeptideAtlas" id="A0A0K3AQS9"/>
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    <sequence length="193" mass="22600" checksum="0B3C3ECA6531E9C7" modified="2015-11-11" version="1">MTLLEEELERAEERLKIATEKLEEATHNVDESERVRKVMENRSLQDEERANTVEAQLKEAQLLAEEADRKYDEVARKLAMVEADLERAEERAEAGENKIVELEEELRVVGNNLKSLEVSEEKALQREDSYEEQIRTVSSRLKEAETRAEFAERSVQKLQKEVDRLEDELVHEKERYKTISEELDSTFQELSGY</sequence>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
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        <source>
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        <source>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AQT4"/>
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    </evidence>
    <sequence length="284" mass="33033" checksum="3FC9019191E2FD7B" modified="2015-11-11" version="1">MDAIKKKMQAMKIEKDNALDRADAAEEKVRQITEKLERVEEELRDTQKKMTQTGDDLDKAQEDLSAATSKLEEKEKTVQEAEAEVASLNRRMTLLEEELERAEERLKIATEKLEEATHNVDESERSRRALSNQIDMDDDRCSDLERKLRECQSILHETENKAEEVARKLAMVEADLERAEERAEAGENKIVELEEELRVVGNNLKSLEVSEEKALQREDSYEEQIRTVSSRLKEAETRAEFAERSVQKLQKEVDRLEDELVHEKERYKTISEELDSTFQELSGY</sequence>
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    <accession>A0A0K3AQT9</accession>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CE50138"/>
        <property type="gene ID" value="WBGene00003060"/>
        <property type="gene designation" value="lpd-3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
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    </dbReference>
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            <begin position="3865"/>
            <end position="3887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CTQ86404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y47G6A.23b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AQT9"/>
        </source>
    </evidence>
    <sequence length="4020" mass="451807" checksum="C0B209F634D1F28D" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AQV8</accession>
    <name>A0A0K3AQV8_CAEEL</name>
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        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">max-2</name>
        <name evidence="17" type="ORF">CELE_Y38F1A.10</name>
        <name evidence="19" type="ORF">Y38F1A.10</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300485.1">
        <property type="nucleotide sequence ID" value="NM_001313556.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AQV8"/>
    <dbReference type="SMR" id="A0A0K3AQV8"/>
    <dbReference type="GeneID" id="3565400"/>
    <dbReference type="AGR" id="WB:WBGene00003144"/>
    <dbReference type="CTD" id="3565400"/>
    <dbReference type="WormBase" id="Y38F1A.10e">
        <property type="protein sequence ID" value="CE50753"/>
        <property type="gene ID" value="WBGene00003144"/>
        <property type="gene designation" value="max-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1022360at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003144">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AQV8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000759">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="16">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="379"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="140"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CTQ86424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="Y38F1A.10e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AQV8"/>
        </source>
    </evidence>
    <sequence length="649" mass="71157" checksum="A3B491F7AE54DE21" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR42</accession>
    <name>A0A0K3AR42_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">etr-1</name>
        <name evidence="4" type="ORF">CELE_T01D1.2</name>
        <name evidence="6" type="ORF">T01D1.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001368530.1">
        <property type="nucleotide sequence ID" value="NM_001381305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR42"/>
    <dbReference type="SMR" id="A0A0K3AR42"/>
    <dbReference type="GeneID" id="173401"/>
    <dbReference type="AGR" id="WB:WBGene00001340"/>
    <dbReference type="CTD" id="173401"/>
    <dbReference type="WormBase" id="T01D1.2u">
        <property type="protein sequence ID" value="CE50532"/>
        <property type="gene ID" value="WBGene00001340"/>
        <property type="gene designation" value="etr-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001340">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR42">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12362">
        <property type="entry name" value="RRM3_CELF1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000569">
        <property type="entry name" value="ELAV-Type RNA binding-protein family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="196"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CTQ86524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="T01D1.2u"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AR42"/>
        </source>
    </evidence>
    <sequence length="281" mass="29019" checksum="27AFEF49667A593D" modified="2015-11-11" version="1">MITGSGAGSPKGGAASLLQNLNPALLQQLGGGQNYQAVASLLSLINGQQGQQQQHQQQQNVLGILGTGNPLLGNPAMAAQNQFDAITMAQIAHQQQMLALQGFAVQQGAPSQQQQGLAGGMAGAKTTSPVAASLANHQQIALTPFAGGAAALDHFQAMQQYALLANLQATGGVGVQATTSAAQMVGNGDVKGPDGANLFIYHLPQDFGDSDLINTFAPFGGILSAKVFIDKVTNLSKCFGFVSYENAQSATNAISAMNGFQIGSKRLKVQLKVDRGNPYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR55</accession>
    <name>A0A0K3AR55_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">chil-25</name>
        <name evidence="3" type="ORF">CELE_T19H5.1</name>
        <name evidence="5" type="ORF">T19H5.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300595.1">
        <property type="nucleotide sequence ID" value="NM_001313666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR55"/>
    <dbReference type="SMR" id="A0A0K3AR55"/>
    <dbReference type="GeneID" id="188614"/>
    <dbReference type="KEGG" id="cel:CELE_T19H5.1"/>
    <dbReference type="AGR" id="WB:WBGene00011846"/>
    <dbReference type="CTD" id="188614"/>
    <dbReference type="WormBase" id="T19H5.1a">
        <property type="protein sequence ID" value="CE50300"/>
        <property type="gene ID" value="WBGene00011846"/>
        <property type="gene designation" value="chil-25"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10063355at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011846">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46073">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46073:SF11">
        <property type="entry name" value="GH18 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="101"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CTQ86534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T19H5.1a"/>
        </source>
    </evidence>
    <sequence length="475" mass="54291" checksum="A1E23E6CFC35421E" modified="2015-11-11" version="1">MINSLILVAFSIFSQTEMSTREEFFELSSPLDFRPDSNLPTRKYLCRTPGKYIYIILFVILMLLLGIWFLIWSFDTVEKKSRTSTIQPKIDPTSTVSNCNKRVVGYYSRSETSKITSVQVSKLTHAVFAFVYMNSDGTLKFEKQDEEDRFMQLKDIVNMGTSPVKIMISIGGKENSQNFSPVIESEYRRQIFINSILTFLKENDLDGIDLFWEWPCSTYKSVYLHFICELKQQLQTKDKDYILSIVVPPPEVGGWIDGFDMNNIVQIVDFINVFSLDYYGPTQNDFGKITGPTAPMFNGVPGRETFNVDHTSKVLSCETMQSNKFNIAIPFYTTLWENVQGPIDKIEIFRNVNKVHGKIVGQSHMSRMIVQQKGFVLTPYSFDNATRNAFIYNSSTKIYLTFETDQSIVAKIEYVSEHLLGGICIWTVDKDDEGNSQLNAISFDGLCTTGNVPKYDCSYWNGNTLPPTQCNLTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR57</accession>
    <name>A0A0K3AR57_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pre-mRNA-splicing factor SYF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_K07A12.5</name>
        <name evidence="2 4" type="ORF">K07A12.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300398.1">
        <property type="nucleotide sequence ID" value="NM_001313469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR57"/>
    <dbReference type="PaxDb" id="6239-K07A12.5"/>
    <dbReference type="GeneID" id="187086"/>
    <dbReference type="KEGG" id="cel:CELE_K07A12.5"/>
    <dbReference type="AGR" id="WB:WBGene00010623"/>
    <dbReference type="CTD" id="187086"/>
    <dbReference type="WormBase" id="K07A12.5a">
        <property type="protein sequence ID" value="CE50455"/>
        <property type="gene ID" value="WBGene00010623"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5798077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010623">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR57">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K07A12.5a"/>
        </source>
    </evidence>
    <sequence length="370" mass="42736" checksum="909088AA5234CDA7" modified="2015-11-11" version="1">MSYKKKMQQRYKLSDDQYETHKKDAQKQLKNWEEFRKEQVVEIFHTQSQYVSKSKNSDVRHPKMQRANTVVNRQGVKVDVEFGRLKEYYLSTLAPQKKFVSIRDHAAREKELDALRKKQKISLEQRKDKQDNIKKSQAEYDQMKSLYAAPVDPKQTKVETMEQKEVLEPTAPMEKFVVNTTDDKRALFPASWYQQPISRSQLKKGKMIYWMAKDEEEDMTLDDDPEGKYTVTAEKLIETMTAGGKVKHAGITEPPSNTANTIMSESLASINARYKKSCERNAVFMNTLHGTIEFNKKQVSVDKTLSTSSISQDDATDAPNQIIFAPTITSHVFKGRSLKRQYAVKNKALETFEEDRKDYTREAGEETSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H4B1</accession>
    <name>A0A168H4B1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srt-12</name>
        <name evidence="2" type="ORF">CELE_E03D2.4</name>
        <name evidence="4" type="ORF">E03D2.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317803.1">
        <property type="nucleotide sequence ID" value="NM_001330844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H4B1"/>
    <dbReference type="SMR" id="A0A168H4B1"/>
    <dbReference type="GeneID" id="184010"/>
    <dbReference type="KEGG" id="cel:CELE_E03D2.4"/>
    <dbReference type="AGR" id="WB:WBGene00017107"/>
    <dbReference type="CTD" id="184010"/>
    <dbReference type="WormBase" id="E03D2.4b">
        <property type="protein sequence ID" value="CE51668"/>
        <property type="gene ID" value="WBGene00017107"/>
        <property type="gene designation" value="srt-12"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5796184at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF14">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SAP35562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="E03D2.4b"/>
        </source>
    </evidence>
    <sequence length="302" mass="34681" checksum="6B9E5C396D31A30D" modified="2016-07-06" version="1">MSNFQMSLAYMLTHSFTLYPDRYKCPENMMIVRTERPILGAYFLISGLILILFYTPCFIVMVRSKCQVPAFQVMLILSVFDILSLSVNSVITGVLDLMGASFCHYPLFIFCAGAIGKGSWMGGCVACILLAVDRCVEVNSKFRLGFLFRKKVFRVVFCLMVLYWIYSWAFTKPLLFTSEYSSWFFDPKIGKEIIMQAVILCTFHAIAAYIYVYMQFFHSPPWLIIIGQLAWQWSNGCFCVSYLTLNQAIRNAVVRMIVPKSIRERLDLHIGIDEHLMNPRQQERGTIAINTVSTLVKVDTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSH2</accession>
    <name>A0A1C3NSH2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phorbol ester/diacylglycerol-binding protein unc-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">unc-13</name>
        <name evidence="11" type="ORF">CELE_ZK524.2</name>
        <name evidence="13" type="ORF">ZK524.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SBV53355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317865.1">
        <property type="nucleotide sequence ID" value="NM_001330928.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1C3NSH2"/>
    <dbReference type="GeneID" id="172497"/>
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    <sequence length="1801" mass="205953" checksum="C39D4F3CF9D8633D" modified="2016-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSI0</accession>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">Bristol N2</strain>
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    </dbReference>
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    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
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            <begin position="351"/>
            <end position="401"/>
        </location>
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        <location>
            <begin position="457"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="9">
        <location>
            <begin position="869"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="10">
        <location>
            <begin position="1115"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1286"/>
            <end position="1414"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
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        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
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        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
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            <begin position="161"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SBV53353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="ZK524.2h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A1C3NSI0"/>
        </source>
    </evidence>
    <sequence length="1472" mass="168357" checksum="ECAB186C9C8A3099" modified="2016-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSI2</accession>
    <name>A0A1C3NSI2_CAEEL</name>
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        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
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        <name evidence="4" type="ORF">CELE_D2007.2</name>
        <name evidence="4 6" type="ORF">D2007.2</name>
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    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
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        <property type="protein sequence ID" value="SBV53367.1"/>
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    </dbReference>
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    <dbReference type="SMR" id="A0A1C3NSI2"/>
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    <dbReference type="CTD" id="183938"/>
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        <property type="gene ID" value="WBGene00017042"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5854456at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017042">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSI2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="MSP_dom"/>
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        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF1">
        <property type="entry name" value="PROTEIN CBG16675"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="32"/>
            <end position="140"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SBV53367.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="D2007.2c"/>
        </source>
    </evidence>
    <sequence length="151" mass="16775" checksum="E5849C9A2C27EF59" modified="2016-11-02" version="1">MEYLMRSARSSRSSGRSERQPGCTCCCHIAAGVTVIPRVARFSIEGGLSTHTLMNHSDNRIAVKITCSDNNMYRVTPVYATVEPGQSLPLHIARITSDLIKRDRLCVNILEADGNKEAREIFKKNANTRAPASINMALEATNDNQNHHHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3A3</accession>
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        <submittedName>
            <fullName evidence="2">Serpentine receptor class gamma</fullName>
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        <name evidence="2 4" type="ORF">C50E3.7</name>
        <name evidence="2" type="ORF">CELE_C50E3.7</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
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            <taxon>Rhabditina</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58825.1"/>
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    </dbReference>
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    <dbReference type="PaxDb" id="6239-C50E3.8"/>
    <dbReference type="GeneID" id="183659"/>
    <dbReference type="KEGG" id="cel:CELE_C50E3.7"/>
    <dbReference type="AGR" id="WB:WBGene00016818"/>
    <dbReference type="CTD" id="183659"/>
    <dbReference type="WormBase" id="C50E3.7b">
        <property type="protein sequence ID" value="CE52147"/>
        <property type="gene ID" value="WBGene00016818"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5871355at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016818">
        <property type="expression patterns" value="Expressed in embryo"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718:SF36">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C50E3.7b"/>
        </source>
    </evidence>
    <sequence length="355" mass="40233" checksum="2C39ADCDB9830E1E" modified="2017-12-20" version="1">MSFSFYFEGSDGKNQEVNIDKPYCPRLKCEDEDYVNELAVALGNSKSTGFLSIAVFVHLTVNVFNFATQLFSAKYIVKFKYFQKSTFFKILLIQCFVVSLRVFLHILTICIIIYVSNTESSVSKFLSQCSLYVDYCSNFFSLTVTFLMSLNRCFCFVSYTWNARIFDGKNVIYSVSIGAVISIVSAVLCIITSQIRRNFLTITGFVDMGPDIGFKVLINRLFFIFPFGSIACYVILFFVIRKQNQQALTKTSNRSRGEHKVFVQLLITAVLYGIMSIVYETINFIYWIDVGIQLAVISVFDVLNYLPEISLPLLLICSSVQIRKAISDWIAPKGDRTMGGVTTEGPRTTSMSNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3A7</accession>
    <name>A0A2C9C3A7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">anc-1</name>
        <name evidence="20" type="ORF">CELE_ZK973.6</name>
        <name evidence="22" type="ORF">ZK973.6</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Single-pass type IV membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus membrane</location>
            <topology evidence="14">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nesprin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SOF58697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343707.1">
        <property type="nucleotide sequence ID" value="NM_001356817.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2C9C3A7"/>
    <dbReference type="GeneID" id="172034"/>
    <dbReference type="AGR" id="WB:WBGene00000140"/>
    <dbReference type="CTD" id="172034"/>
    <dbReference type="WormBase" id="ZK973.6c">
        <property type="protein sequence ID" value="CE52179"/>
        <property type="gene ID" value="WBGene00000140"/>
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        <property type="entry name" value="SCP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012925899" evidence="1">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K02E11.4c"/>
        </source>
    </evidence>
    <sequence length="94" mass="10188" checksum="C55D8EA9ABB6E48D" modified="2017-12-20" version="1">MVRTCILAIFSLLVIGTNSQPGGGGMPGGGGMMYGKVNATVTISLPNKKKVPSGVTTYNKNKKALIIKKMRLEDFGDYMTGNKKTKLFVMNQTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3B5</accession>
    <name>A0A2C9C3B5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_T19D12.1</name>
        <name evidence="3 5" type="ORF">T19D12.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2C9C3B5"/>
    <dbReference type="AGR" id="WB:WBGene00020576"/>
    <dbReference type="WormBase" id="T19D12.1c">
        <property type="protein sequence ID" value="CE52151"/>
        <property type="gene ID" value="WBGene00020576"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5872342at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020576">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3B5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37972:SF2">
        <property type="entry name" value="PRION-LIKE-(Q_N-RICH)-DOMAIN-BEARING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37972">
        <property type="entry name" value="PROTEIN CBG25533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="825"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SOF58775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T19D12.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3B5"/>
        </source>
    </evidence>
    <sequence length="1679" mass="171074" checksum="0C9C96EA50BD9ABE" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3B7</accession>
    <name>A0A2C9C3B7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Muscle M-line assembly protein unc-89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">unc-89</name>
        <name evidence="19" type="ORF">C09D1.1</name>
        <name evidence="17" type="ORF">CELE_C09D1.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Myofibril</location>
            <location evidence="8">Sarcomere</location>
            <location evidence="8">M line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SOF58707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343717.1">
        <property type="nucleotide sequence ID" value="NM_001356807.3"/>
    </dbReference>
    <dbReference type="GeneID" id="171990"/>
    <dbReference type="AGR" id="WB:WBGene00006820"/>
    <dbReference type="CTD" id="171990"/>
    <dbReference type="WormBase" id="C09D1.1n">
        <property type="protein sequence ID" value="CE52393"/>
        <property type="gene ID" value="WBGene00006820"/>
        <property type="gene designation" value="unc-89"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006820">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3B7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of striated muscle contraction"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="IgI_telokin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14112">
        <property type="entry name" value="STKc_Unc-89_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000902">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="48"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
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    </dbReference>
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        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007850">
        <property type="entry name" value="RCSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
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        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF3">
        <property type="entry name" value="STRIATED MUSCLE PREFERENTIALLY EXPRESSED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05177">
        <property type="entry name" value="RCSD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="44"/>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="38"/>
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        <property type="entry name" value="IGv"/>
        <property type="match status" value="4"/>
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    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <begin position="19"/>
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            <dbReference type="EMBL" id="SOF58844.1"/>
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            <dbReference type="Proteomes" id="UP000001940"/>
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        <source>
            <dbReference type="WormBase" id="F36D4.4a"/>
        </source>
    </evidence>
    <sequence length="452" mass="51651" checksum="C17DCBD624E8CF1A" modified="2017-12-20" version="1">MATTAVFLCGHLGALSVILNLFVIIALLRHRRRVLSNVFYVIVLHCAVLDVARGVCLILYGLPYFANSFYNINLDIHTRIHLFQLSRFALVILRVCNLLTIFNLLVFTTNEYIVIRYPLHYRRYFRRKFVLIILAICWTMSIMMALGILYSSSKSQTEWLPPEERGIDFATITMVLISSLCFVTLGTVVICYISILRTIRKFKDEGCLNNDESHRIHNRSLHRPINGQGSNCSNGSRGSKWRSVQAMSRHKYIYVIGSVLIVDLLFLCPYSGIQMVSFLHINNFLQITHGSTLIRWWLQVLIGVHSVCQPLCYFRMTEFRRLACCNPRRPWNRTKSFSQMNKSFANTRSNVREDENGNNTAEIEVTPNEPLLRNGENGGTPSRRSPTIAWTRGESVRFRTYGNEIGHHIPTKKNESKEPQCEIEMIPISTGSASPSDDSAVQIPIIDDSPLV</sequence>
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        </source>
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        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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            <dbReference type="EMBL" id="SOF58854.1"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="702" mass="77671" checksum="ADB05A8DAE6BD716" modified="2017-12-20" version="1"> </sequence>
</entry>
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    <reference evidence="2 3" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58849.1"/>
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    <dbReference type="AGR" id="WB:WBGene00018429"/>
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        <property type="gene ID" value="WBGene00018429"/>
    </dbReference>
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="51"/>
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            <begin position="84"/>
            <end position="106"/>
        </location>
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            <dbReference type="EMBL" id="SOF58849.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F44E7.7b"/>
        </source>
    </evidence>
    <sequence length="117" mass="12873" checksum="D761F7BC67BBA3AC" modified="2017-12-20" version="1">MIGLAAGFVVMSLTSSRTIAQISYTFAVTLSGITIMGTVKCLQLRCQQHVHFATVVVAFMACIWQFLVPLGVGYLCPNNTPEEWSFLFFIVSGIVLIVNIPFPFLTTAEAADYAKRF</sequence>
</entry>
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    <accession>A0A2X0REL6</accession>
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        <submittedName>
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        </submittedName>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="CE52654"/>
        <property type="gene ID" value="WBGene00006657"/>
        <property type="gene designation" value="twk-2"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
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        </source>
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</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12348">
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            <begin position="622"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAD8118568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A7R9XN21"/>
        </source>
    </evidence>
    <sequence length="659" mass="70275" checksum="F68DE3F52E61BA5D" modified="2021-06-02" version="1"> </sequence>
</entry>
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    <accession>A0A7R9XN27</accession>
    <name>A0A7R9XN27_CAEEL</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="4 6" type="primary">nos-3</name>
        <name evidence="4" type="ORF">CELE_Y53C12B.3</name>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nanos family.</text>
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    <dbReference type="SMR" id="A0A7R9XN27"/>
    <dbReference type="GeneID" id="174535"/>
    <dbReference type="AGR" id="WB:WBGene00003785"/>
    <dbReference type="CTD" id="174535"/>
    <dbReference type="WormBase" id="Y53C12B.3e">
        <property type="protein sequence ID" value="CE54300"/>
        <property type="gene ID" value="WBGene00003785"/>
        <property type="gene designation" value="nos-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870823at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05741">
        <property type="entry name" value="zf-nanos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nanos-type" evidence="3">
        <location>
            <begin position="583"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="754"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
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        </location>
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            <end position="121"/>
        </location>
    </feature>
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            <end position="146"/>
        </location>
    </feature>
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        </location>
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            <begin position="252"/>
            <end position="264"/>
        </location>
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            <end position="436"/>
        </location>
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            <end position="484"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD8118740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y53C12B.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A7R9XN27"/>
        </source>
    </evidence>
    <sequence length="754" mass="83448" checksum="A0D9696557C284A2" modified="2021-06-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7R9XN32</accession>
    <name>A0A7R9XN32_CAEEL</name>
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        <recommendedName>
            <fullName evidence="2">ATP synthase subunit s-like protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">CELE_Y53G8AR.8</name>
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    </gene>
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        <name type="scientific">Caenorhabditis elegans</name>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP synthase subunit s family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAD8126359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7R9XN32"/>
    <dbReference type="SMR" id="A0A7R9XN32"/>
    <dbReference type="AGR" id="WB:WBGene00021815"/>
    <dbReference type="WormBase" id="Y53G8AR.8b">
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        <property type="gene ID" value="WBGene00021815"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1708588at2759"/>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000168">
        <property type="entry name" value="Distal membrane arm assembly complex 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
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        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006901"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CAD8126359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y53G8AR.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A7R9XN32"/>
        </source>
    </evidence>
    <sequence length="446" mass="51610" checksum="CF08E0974CA6D68C" modified="2021-06-02" version="1">MNRVYCTARSFRTSVKSNGWVHKWSRFKRWQEMQAAHVENVQEKQRNKNFIRLPTGLYITPERPDDLNPKKAPADMTRKDTGQLPMELLTWHTQMRYVDHSIDNIKRYRRYKKVIPERLLFLGPDLAAAHFLVHRGAAVKFVGDDNWYKKDKWNRYSLPGRKVDNLFIEAIDASGTQIMFEGLENLENLQKLRLLRLANSEYVDDWCIGRIGGLLPNLEMLDLSGCHRISSKGLMGLKASKNLKFLRLEGLSGIRNLGKSALILEDLLPKLQILGMDYELSFRQIEAENRLLEQERVVLDGRGNAFVEDDNSRLFLVMSTSSDDKAVTDDHDNPIMTSTVRREIPKMDDAEFEEINALSGGKLRHLLVGSPSGYEWTETTERILEHEAELNLTDNVITDPKMLPRGKRPEFELPEHRSRLEDAKAQFLKEFGDFEENSDKEQLKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I6W5</accession>
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        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3 5" type="primary">rtkn-1</name>
        <name evidence="5" type="ORF">C07B5.4</name>
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    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="WBGene00007409"/>
        <property type="gene designation" value="rtkn-1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001940">
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        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG8860261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C07B5.4d"/>
        </source>
    </evidence>
    <sequence length="470" mass="52048" checksum="13B88310C6505304" modified="2022-01-19" version="1">MLPGDGLGLSPTSSRANVGLSQISLPLAWKPKETRTFSMFLVIQSKTRVIDTKIISHVDKNMTDVIIPDSFVFDNEPEDFNVDILIYAARTDYGLENNTGGSLKSRITRSIGRKFGSSVKSQVSTPEMLKSPRLDQTISGAHYNLLAKATLSIADACEEATIHNLRMSAFADLSGPPLYGHIICRLAIQPHSVLRPILEGVLSVQHVEEGVELENTAARLQAGNLHFYSIGDIANSSKNTVLIIPLSSRSRIVPTPSARTFLLRTDESKEVPASSVYIVTNSDRDYEIWRRAIEIQIYDIGIWGRFATKISSLLTQKREDPIRETLSRGTGSNLYETISIKGSISKAFGGLSLVPCDGQPHPNGAATAPVKRPQVKQRAKVIDFFQAQSPKPSRKSIIHEPSSNYVIQLNIGEDVMENEYNSYSPLYRMSPRPPSSYRHHSDDQYKDGKKSWSKSIGSLINRNASHVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4QF54</accession>
    <name>A0A8S4QF54_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activated in Blocked Unfolded protein response</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">appg-1</name>
        <name evidence="2" type="ORF">CELE_M02G9.1</name>
        <name evidence="4" type="ORF">M02G9.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAH2171118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001391116.1">
        <property type="nucleotide sequence ID" value="NM_001404234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8S4QF54"/>
    <dbReference type="GeneID" id="174597"/>
    <dbReference type="AGR" id="WB:WBGene00010830"/>
    <dbReference type="CTD" id="174597"/>
    <dbReference type="WormBase" id="M02G9.1d">
        <property type="protein sequence ID" value="CE54452"/>
        <property type="gene ID" value="WBGene00010830"/>
        <property type="gene designation" value="appg-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5813501at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33750:SF2">
        <property type="entry name" value="ACTIVATED IN BLOCKED UNFOLDED PROTEIN RESPONSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33750">
        <property type="entry name" value="PROTEIN CBG02727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035907978" evidence="1">
        <location>
            <begin position="23"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH2171118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="M02G9.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4QF54"/>
        </source>
    </evidence>
    <sequence length="633" mass="66663" checksum="6FA7ABBB89D052A9" modified="2022-10-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4QF65</accession>
    <name>A0A8S4QF65_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">lin-29</name>
        <name evidence="12" type="ORF">CELE_W03C9.4</name>
        <name evidence="14" type="ORF">W03C9.4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAH2171942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001407504.1">
        <property type="nucleotide sequence ID" value="NM_001420602.1"/>
    </dbReference>
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    <dbReference type="WormBase" id="W03C9.4j">
        <property type="protein sequence ID" value="CE54418"/>
        <property type="gene ID" value="WBGene00003015"/>
        <property type="gene designation" value="lin-29"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein rotund"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH2171942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="W03C9.4j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8S4QF65"/>
        </source>
    </evidence>
    <sequence length="313" mass="34807" checksum="9472B33137B33D57" modified="2022-10-12" version="1">MQMREAKPYKCTQCVKAFANSSYLSQHMRIHLGIKPFGPCNYCGKKFTQLSHLQQHIRTHTGEKPYKCKFTGCDKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFTDEQSLLDHIPKHKESKHLKIHICPFCGKSYTQQTYLQKHMTKHADRSKASNFGNDVVPADPFDPSLLSWNPMQGMGDNAHDSSSFNINQFAANTMIGSQSTNYNPAFQNSAFSQLFNIRNNRYLSEYPTSTKNGERAPGFNMITPLENIQRYNGSSSSATAVVTATGSAVVSSTPSSTSSSSAGSSSSQGGVFNPQSLINNMKNHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-06-28" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9J5HXB2</accession>
    <name>A0A9J5HXB2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">aprt-1</name>
        <name evidence="13" type="ORF">CELE_T19B4.3</name>
        <name evidence="15" type="ORF">T19B4.3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAI3820551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001407543.1">
        <property type="nucleotide sequence ID" value="NM_001420561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9J5HXB2"/>
    <dbReference type="SMR" id="A0A9J5HXB2"/>
    <dbReference type="GeneID" id="172232"/>
    <dbReference type="AGR" id="WB:WBGene00020557"/>
    <dbReference type="CTD" id="172232"/>
    <dbReference type="WormBase" id="T19B4.3b">
        <property type="protein sequence ID" value="CE54564"/>
        <property type="gene ID" value="WBGene00020557"/>
        <property type="gene designation" value="aprt-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAI3820551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="T19B4.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="A0A9J5HXB2"/>
        </source>
    </evidence>
    <sequence length="152" mass="16162" checksum="E98133CCE310FF35" modified="2023-06-28" version="1">MPLFTNPQLVNELCVVIADHVRHTVGHVDSVAGLEARGFLFGPQVAIQLGVPFVPIRKKGKLPGATIEASYVKEYGEDRVEIQEGAIKNGDIVFLIDDLLATGGTLRAATDLVVKAGGKVGEAFVLIELAPLNGRSKLPDVNLTTLISYDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2026-01-28" modified="2026-01-28" version="1" xmlns="https://uniprot.org/uniprot">
    <accession>A0ACB0I4H0</accession>
    <name>A0ACB0I4H0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein NOB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">nobh-1</name>
        <name evidence="1" type="ORF">CELE_Y54E10BR.4</name>
        <name evidence="3" type="ORF">Y54E10BR.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAJ1466077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WormBase" id="Y54E10BR.4b">
        <property type="protein sequence ID" value="CE54586"/>
        <property type="gene ID" value="WBGene00021843"/>
        <property type="gene designation" value="nobh-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ1466077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y54E10BR.4b"/>
        </source>
    </evidence>
    <sequence length="280" mass="31621" checksum="7F4F57A8462F3497" modified="2026-01-28" version="1">MVDIKMIALTYDLHRQYVAENDVAETTEDDEKKNIEDLSAKVEQVTVGENTEDTKEEEIEENEESEDSAVSEGSESSESSESFDEDGWITQDNIEETLKKLGAFEIEENMLVGCLTTDFALQNVLLAMNLSLVSLSGYRIRKLKSFVLRCRTCFSTTSVMTKEFCPACGHKTLHKCAVSVDEDGNQQLHINWNRMANRRGLVYTLANPKGGKHATNERLFEDQPMPHMRMAKIHMDPLADGPFSVHDVTSRSAMLGVRTINNRAKQNRNPNESKRGGRRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-01-09" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>A7IQW5-2</accession>
    <name>MT21_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Protein-lysine methyltransferase vkmt-1</fullName>
            <ecNumber>2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Valosin containing protein lysine (K) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">vkmt-1</name>
        <name type="ORF">C42C1.13</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="Nat. Commun." volume="3" first="1038" last="1038">
            <title>Lysine methylation of VCP by a member of a novel human protein methyltransferase family.</title>
            <authorList>
                <person name="Kernstock S."/>
                <person name="Davydova E."/>
                <person name="Jakobsson M."/>
                <person name="Moen A."/>
                <person name="Pettersen S."/>
                <person name="Maelandsmo G.M."/>
                <person name="Egge-Jacobsen W."/>
                <person name="Falnes P.O."/>
            </authorList>
            <dbReference type="PubMed" id="22948820"/>
            <dbReference type="DOI" id="10.1038/ncomms2041"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A7IQW5-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A7IQW5-2</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_044622"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.1.1.-"/>
    <dbReference type="RefSeq" id="NP_502334.2">
        <property type="nucleotide sequence ID" value="NM_069933.7"/>
    </dbReference>
    <dbReference type="WormBase" id="C42C1.13a">
        <property type="protein sequence ID" value="CE39692"/>
        <property type="gene ID" value="WBGene00016591"/>
        <property type="gene designation" value="vkmt-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C42C1.13a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C42C1.13b"/>
        </source>
    </evidence>
    <sequence length="167" mass="18843" checksum="AFDE513A0E5A8F24" modified="2007-09-11" version="1">MTIHYFFKYPKPFEGKKVLELGSGTGVGGIALAALGADVIITDLPERLALIEKNVEANRKLTGNRIKVQVLDWTKDRIPEGLDMVLAIDCVYYNSTIDPLITLLNDCDAKEIMVVSEERDIGEAHLAQKSFFKDIQKFFRLELIPQKELDEDYCADDIIIGKLIRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-11-13" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>A8DYR9</accession>
    <name>A8DYR9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">etr-1</name>
        <name evidence="5" type="ORF">CELE_T01D1.2</name>
        <name evidence="7" type="ORF">T01D1.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD71500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367869.1">
        <property type="nucleotide sequence ID" value="NM_001381302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8DYR9"/>
    <dbReference type="PeptideAtlas" id="A8DYR9"/>
    <dbReference type="GeneID" id="173401"/>
    <dbReference type="UCSC" id="T01D1.2a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001340"/>
    <dbReference type="CTD" id="173401"/>
    <dbReference type="WormBase" id="T01D1.2b">
        <property type="protein sequence ID" value="CE41582"/>
        <property type="gene ID" value="WBGene00001340"/>
        <property type="gene designation" value="etr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_788080_0_0_1"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001340">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A8DYR9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd12362">
        <property type="entry name" value="RRM3_CELF1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000569">
        <property type="entry name" value="ELAV-Type RNA binding-protein family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="267"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD71500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="T01D1.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="A8DYR9"/>
        </source>
    </evidence>
    <sequence length="352" mass="36582" checksum="D4BB277E360E8970" modified="2007-11-13" version="1">MITGSGAGSPKGGAASLLQNLNPALLQQLGGGQNYQAVASLLSLINGQQGQQQQHQQQQNVLGILGTVLSALGKLTEGGDDASAKSSSEKPRHQALMTSPAPTATSSTSSSASHHHQQHQQQLSQQQQQQQHPQQQGLGNPLLGNPAMAAQNQFDAITMAQIAHQQQMLALQGFAVQQGAPSQQQQGLAGGMAGAKTTSPVAASLANHQQIALTPFAGGAAALDHFQAMQQYALLANLQATGGVGVQATTSAAQMVGNGDVKGPDGANLFIYHLPQDFGDSDLINTFAPFGGILSAKVFIDKVTNLSKCFGFVSYENAQSATNAISAMNGFQIGSKRLKVQLKVDRGNPYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-11-13" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>A8DYS0</accession>
    <name>A8DYS0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">etr-1</name>
        <name evidence="7" type="ORF">CELE_T01D1.2</name>
        <name evidence="9" type="ORF">T01D1.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CELF/BRUNOL family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD71502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367871.1">
        <property type="nucleotide sequence ID" value="NM_001381292.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8DYS0"/>
    <dbReference type="SMR" id="A8DYS0"/>
    <dbReference type="IntAct" id="A8DYS0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PaxDb" id="6239-T01D1.2f.4"/>
    <dbReference type="GeneID" id="173401"/>
    <dbReference type="UCSC" id="T01D1.2a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001340"/>
    <dbReference type="CTD" id="173401"/>
    <dbReference type="WormBase" id="T01D1.2f">
        <property type="protein sequence ID" value="CE41585"/>
        <property type="gene ID" value="WBGene00001340"/>
        <property type="gene designation" value="etr-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="PhylomeDB" id="A8DYS0"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001340">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A8DYS0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd12631">
        <property type="entry name" value="RRM1_CELF1_2_Bruno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12636">
        <property type="entry name" value="RRM2_Bruno_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12362">
        <property type="entry name" value="RRM3_CELF1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000013">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000569">
        <property type="entry name" value="ELAV-Type RNA binding-protein family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000641">
        <property type="entry name" value="ELAV-Type RNA binding-protein family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034196">
        <property type="entry name" value="CELF1/2_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="55"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="142"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="503"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD71502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A8DYS0"/>
        </source>
    </evidence>
    <sequence length="588" mass="62868" checksum="B51345CC29475A52" modified="2007-11-13" version="1"> </sequence>
</entry>
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    <accession>A8DYS1</accession>
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            <dbReference type="ARBA" id="ARBA00009621"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50102"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD71501.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="T01D1.2e"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A8DYS1"/>
        </source>
    </evidence>
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</entry>
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    <accession>A8DYS3</accession>
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            <strain evidence="7 8">Bristol N2</strain>
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    </reference>
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    <dbReference type="SMR" id="A8DYS3"/>
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    <dbReference type="CTD" id="173401"/>
    <dbReference type="WormBase" id="T01D1.2d">
        <property type="protein sequence ID" value="CE41583"/>
        <property type="gene ID" value="WBGene00001340"/>
        <property type="gene designation" value="etr-1"/>
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    <dbReference type="PANTHER" id="PTHR24012">
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    <dbReference type="SUPFAM" id="SSF54928">
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    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
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        <location>
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            <begin position="312"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009621"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD71499.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="T01D1.2d"/>
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    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="A8DYS3"/>
        </source>
    </evidence>
    <sequence length="535" mass="57547" checksum="684EA693067C52FD" modified="2007-11-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-11-13" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Neurexin-3-beta</fullName>
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    <gene>
        <name evidence="2 4" type="primary">nrx-1</name>
        <name evidence="4" type="ORF">C29A12.4</name>
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    <organism evidence="2 3">
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAP09177.1"/>
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    <dbReference type="AlphaFoldDB" id="A8DZ40"/>
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    <dbReference type="AGR" id="WB:WBGene00007799"/>
    <dbReference type="CTD" id="42646"/>
    <dbReference type="WormBase" id="C29A12.4i">
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        <property type="gene ID" value="WBGene00007799"/>
        <property type="gene designation" value="nrx-1"/>
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    <dbReference type="OrthoDB" id="6275838at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007799">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A8DZ40">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAP09177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C29A12.4i"/>
        </source>
    </evidence>
    <sequence length="100" mass="11313" checksum="3BD274A1A3FEB5B6" modified="2007-11-13" version="1">MVFLEHLRGGTPRGTTTVSPILCLMNWNDEQCRQQLKSYIPKFASNFDAPRHVPQPPSSPSYDYEGDEDEEKKEEKDHGIADRSMNDVSGETTGRMCFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-11-13" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>A8DZ44</accession>
    <name>A8DZ44_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GLOBIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T19C4.5</name>
        <name evidence="2 4" type="ORF">T19C4.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAP09187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123017.1">
        <property type="nucleotide sequence ID" value="NM_001129545.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8DZ44"/>
    <dbReference type="SMR" id="A8DZ44"/>
    <dbReference type="GeneID" id="188594"/>
    <dbReference type="UCSC" id="T19C4.5a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011839"/>
    <dbReference type="CTD" id="188594"/>
    <dbReference type="WormBase" id="T19C4.5b">
        <property type="protein sequence ID" value="CE41590"/>
        <property type="gene ID" value="WBGene00011839"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065869_0_0_1"/>
    <dbReference type="OrthoDB" id="5810844at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011839">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A8DZ44">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAP09187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T19C4.5b"/>
        </source>
    </evidence>
    <sequence length="265" mass="30245" checksum="50507471F2FCC440" modified="2007-11-13" version="1">MGRRMFEHVFTENPQYLAFIDLKNEVNWWNHINFKIHVQRFVTVLIETMRRLKEPSTSIDILRDFGAIYAKYPKRVSALYFERLANSMNEAAGQLQESDHLDVEKTQSRMEDAVTDSSSTDNTSNMCNSCTSLSSGQRYPKPLTTRNSETQMQTLKEESSFCSSCVSSRRCSHEVDGVKSVCPITSEAWLVLSAYIANQIKFGYELEKLLINEMSKLGIDTLPCQMGDSAETESDGQESNNHSHNHHHRSTTSSSRFTEQQSQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-11-13" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A8DZ45</accession>
    <name>A8DZ45_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin-like protein vab-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">vab-8</name>
        <name evidence="3" type="ORF">CELE_K12F2.2</name>
        <name evidence="5" type="ORF">K12F2.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAP09183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122977.1">
        <property type="nucleotide sequence ID" value="NM_001129505.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8DZ45"/>
    <dbReference type="SMR" id="A8DZ45"/>
    <dbReference type="GeneID" id="179675"/>
    <dbReference type="UCSC" id="K12F2.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006874"/>
    <dbReference type="CTD" id="179675"/>
    <dbReference type="WormBase" id="K12F2.2c">
        <property type="protein sequence ID" value="CE21070"/>
        <property type="gene ID" value="WBGene00006874"/>
        <property type="gene designation" value="vab-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287890_0_0_1"/>
    <dbReference type="OrthoDB" id="8862460at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006874">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A8DZ45">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005865">
        <property type="term" value="C:striated muscle thin filament"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008078">
        <property type="term" value="P:mesodermal cell migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040025">
        <property type="term" value="P:vulval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608:SF7">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAP09183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K12F2.2c"/>
        </source>
    </evidence>
    <sequence length="617" mass="68998" checksum="8E72B134AA56E740" modified="2007-11-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQ95</accession>
    <name>D3NQ95_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF547 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y45F10A.7</name>
        <name evidence="3 5" type="ORF">Y45F10A.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255747.1">
        <property type="nucleotide sequence ID" value="NM_001268818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQ95"/>
    <dbReference type="PeptideAtlas" id="D3NQ95"/>
    <dbReference type="GeneID" id="178318"/>
    <dbReference type="AGR" id="WB:WBGene00012869"/>
    <dbReference type="CTD" id="178318"/>
    <dbReference type="WormBase" id="Y45F10A.7c">
        <property type="protein sequence ID" value="CE44679"/>
        <property type="gene ID" value="WBGene00012869"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012751_1_0_1"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012869">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQ95">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF5">
        <property type="entry name" value="DEP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF547" evidence="2">
        <location>
            <begin position="122"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBK19502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y45F10A.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D3NQ95"/>
        </source>
    </evidence>
    <sequence length="351" mass="40233" checksum="5BC0F1C48FB2C2EF" modified="2010-04-20" version="1">MRQKGIKRSEALEIGQELIDRHVGQQTSKESGMTFSPDRYYQLVEDDENKPLNAGEDDGDKKQSFPVAECNEKFSKLLKPIFNDILTDDNQSIIYGGLSTNDNFTRYLQFSRELNHVTFEGSTSDDRLTFFINVYNMMLIHITLKHGPPIGIWQRRKLVNGTYYLIGGHRYALHSIINGILRGNKKGPGMLWKAFGKQDARLPISLAVCDPLIYFSLCSGSKTTPPLRVYHSKSIHQEMRENARQTLLRGDKFLRVDMKKNVIHLGKTFKWFSDDFGGSTEKILQWILDVLDTNESDKKHNLQKLFFTGEYSIEYIPYDWSTNGRMDEKEREDIDGGGGGGGDVRRTKTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQ96</accession>
    <name>D3NQ96_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF547 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y45F10A.7</name>
        <name evidence="3 5" type="ORF">Y45F10A.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255748.1">
        <property type="nucleotide sequence ID" value="NM_001268819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQ96"/>
    <dbReference type="GeneID" id="178318"/>
    <dbReference type="AGR" id="WB:WBGene00012869"/>
    <dbReference type="CTD" id="178318"/>
    <dbReference type="WormBase" id="Y45F10A.7d">
        <property type="protein sequence ID" value="CE44652"/>
        <property type="gene ID" value="WBGene00012869"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012751_1_0_1"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012869">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQ96">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF5">
        <property type="entry name" value="DEP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF547" evidence="2">
        <location>
            <begin position="90"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBK19503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y45F10A.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D3NQ96"/>
        </source>
    </evidence>
    <sequence length="319" mass="36641" checksum="0D6BB3EE4C08F734" modified="2010-04-20" version="1">MTFSPDRYYQLVEDDENKPLNAGEDDGDKKQSFPVAECNEKFSKLLKPIFNDILTDDNQSIIYGGLSTNDNFTRYLQFSRELNHVTFEGSTSDDRLTFFINVYNMMLIHITLKHGPPIGIWQRRKLVNGTYYLIGGHRYALHSIINGILRGNKKGPGMLWKAFGKQDARLPISLAVCDPLIYFSLCSGSKTTPPLRVYHSKSIHQEMRENARQTLLRGDKFLRVDMKKNVIHLGKTFKWFSDDFGGSTEKILQWILDVLDTNESDKKHNLQKLFFTGEYSIEYIPYDWSTNGRMDEKEREDIDGGGGGGGDVRRTKTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQ97</accession>
    <name>D3NQ97_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integrin Cytoplasmic domain-Associated Protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">icap-1</name>
        <name evidence="1" type="ORF">CELE_Y45F10D.10</name>
        <name evidence="3" type="ORF">Y45F10D.10</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255758.1">
        <property type="nucleotide sequence ID" value="NM_001268829.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQ97"/>
    <dbReference type="SMR" id="D3NQ97"/>
    <dbReference type="GeneID" id="189926"/>
    <dbReference type="AGR" id="WB:WBGene00012889"/>
    <dbReference type="CTD" id="189926"/>
    <dbReference type="WormBase" id="Y45F10D.10b">
        <property type="protein sequence ID" value="CE44556"/>
        <property type="gene ID" value="WBGene00012889"/>
        <property type="gene designation" value="icap-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1723947_0_0_1"/>
    <dbReference type="OrthoDB" id="10060702at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012889">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQ97">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0401">Integrin</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y45F10D.10b"/>
        </source>
    </evidence>
    <sequence length="98" mass="10924" checksum="AA264952325D2CE5" modified="2010-04-20" version="1">MEVTKHGLRISSRRTRLVKLRIPLIELILLTTYADGFGRTNIVFVEKSTTTRYQLHLLQATDDASSNILCNLVKNAFIEAEEASALIEVIEPPSPSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>D3NQ99</accession>
    <name>D3NQ99_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methanethiol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">semo-1</name>
        <name evidence="3" type="ORF">CELE_Y37A1B.5</name>
        <name evidence="5" type="ORF">Y37A1B.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenium-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255778.1">
        <property type="nucleotide sequence ID" value="NM_001268849.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3NQ99"/>
    <dbReference type="SMR" id="D3NQ99"/>
    <dbReference type="PeptideAtlas" id="D3NQ99"/>
    <dbReference type="GeneID" id="178360"/>
    <dbReference type="AGR" id="WB:WBGene00012538"/>
    <dbReference type="CTD" id="178360"/>
    <dbReference type="WormBase" id="Y37A1B.5b">
        <property type="protein sequence ID" value="CE44562"/>
        <property type="gene ID" value="WBGene00012538"/>
        <property type="gene designation" value="semo-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032512_0_0_1"/>
    <dbReference type="OrthoDB" id="10252446at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012538">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3NQ99">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008826">
        <property type="entry name" value="Se-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300:SF0">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05694">
        <property type="entry name" value="SBP56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBK19492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y37A1B.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D3NQ99"/>
        </source>
    </evidence>
    <sequence length="164" mass="18632" checksum="9B0E8CDEE42249CF" modified="2010-04-20" version="1">MPALITDILISMDDRFLYVSCWLHGDIRQYDISDPLKVKLNSQVYIGGSVHTESNVKVLEGEKPIEALYVKGRKIEGGPQMLQLSLDGKRLYVTTSLYKKWDDQFYPEHVKSGATMVQVNIDPESGKMEINRDFLIDFGKIEGGPYLAHEMRYPGGDCTSDIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G4RUC0</accession>
    <name>G4RUC0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prion-like-(Q/N-rich)-domain-bearing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">idpp-15</name>
        <name evidence="3" type="ORF">CELE_ZC21.3</name>
        <name evidence="5" type="ORF">ZC21.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD62578.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367405.1">
        <property type="nucleotide sequence ID" value="NM_001379833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4RUC0"/>
    <dbReference type="GeneID" id="191053"/>
    <dbReference type="AGR" id="WB:WBGene00022505"/>
    <dbReference type="CTD" id="191053"/>
    <dbReference type="WormBase" id="ZC21.3b">
        <property type="protein sequence ID" value="CE54077"/>
        <property type="gene ID" value="WBGene00022505"/>
        <property type="gene designation" value="idpp-15"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067654_0_0_1"/>
    <dbReference type="OrthoDB" id="5875516at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022505">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G4RUC0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0034">Amyloid</keyword>
    <keyword evidence="3" id="KW-0640">Prion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025598017" evidence="2">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD62578.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="ZC21.3b"/>
        </source>
    </evidence>
    <sequence length="205" mass="22547" checksum="CC16E32B1DBAAF4A" modified="2020-06-17" version="2">MMLRVLVFTSLVALSIAQLTSSCPSCNTNSNYGTSSGSSSYNTNGVQRDSTDGSSNNQPGYLPDYQGDRYTDPQRIAETQALNKAFFDSIGGAPSPPPLTPAQQGMNGSSSSTGQYNQQQYNSQQQQPQQQYNTQQYNPQQQQYNPQQQQQYGTTSFSSNGQAMYQTGTTNYPTLYQPSSSSPQYSNGCTTCRFRRHFGFGPAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY02</accession>
    <name>G8JY02_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="5">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 23" type="primary">daf-4</name>
        <name evidence="23" type="ORF">C05D2.1</name>
        <name evidence="21" type="ORF">CELE_C05D2.1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="5"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021149.1">
        <property type="nucleotide sequence ID" value="NM_001025978.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY02"/>
    <dbReference type="SMR" id="G8JY02"/>
    <dbReference type="PeptideAtlas" id="G8JY02"/>
    <dbReference type="GeneID" id="175781"/>
    <dbReference type="AGR" id="WB:WBGene00000900"/>
    <dbReference type="CTD" id="175781"/>
    <dbReference type="WormBase" id="C05D2.1d">
        <property type="protein sequence ID" value="CE33555"/>
        <property type="gene ID" value="WBGene00000900"/>
        <property type="gene designation" value="daf-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_614279_0_0_1"/>
    <dbReference type="OrthoDB" id="547665at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000900">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY02">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040024">
        <property type="term" value="P:dauer larval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030513">
        <property type="term" value="P:positive regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd23617">
        <property type="entry name" value="TFP_LU_ECD_Daf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000958">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF100">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 19" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003511045" description="receptor protein serine/threonine kinase" evidence="19">
        <location>
            <begin position="32"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="306"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCD63120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WormBase" id="C05D2.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PeptideAtlas" id="G8JY02"/>
        </source>
    </evidence>
    <sequence length="446" mass="50831" checksum="1E23AC85BF5FA481" modified="2012-01-25" version="1">MNQKGTVRLKALVLICLPLFLIATPVPVAVTEDDRQDRIESEAAEKEWANTLVSKVAQSNGTGTIKVSAPAKPTLRRMDNEEDEVISIECVYYDEMECEKSGDCEITKKTCYSEAHLKAVGCLAVFGLPTQEINSTEPYLKVDKPQYKSLGCMPYQHADSMNCENESSCRQGRSFRGGIGMCCCSTNNCNMPDLIEMVNPSLKKDSDNSALLWASTPSNMDLESLDKFPFYWIIIIALSVILCIALLILAYVGWKFQQNKKEEIKKQQKIKFDMEKTDALEAGNVPLVEPEEEMIEMVETPKELPITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEKIGDEYWIVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFFGHPKKPIIHRLVENENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY03</accession>
    <name>G8JY03_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DEAH box protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">ddx-15</name>
        <name evidence="16" type="ORF">CELE_F56D2.6</name>
        <name evidence="18" type="ORF">F56D2.6</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741148.2">
        <property type="nucleotide sequence ID" value="NM_171131.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G8JY03"/>
    <dbReference type="SMR" id="G8JY03"/>
    <dbReference type="PeptideAtlas" id="G8JY03"/>
    <dbReference type="GeneID" id="175771"/>
    <dbReference type="AGR" id="WB:WBGene00018967"/>
    <dbReference type="CTD" id="175771"/>
    <dbReference type="WormBase" id="F56D2.6b">
        <property type="protein sequence ID" value="CE32900"/>
        <property type="gene ID" value="WBGene00018967"/>
        <property type="gene designation" value="ddx-15"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018967">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY03">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
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        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
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        <property type="entry name" value="DHX15_DEXHc"/>
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        <property type="entry name" value="HA2_WH"/>
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    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="86"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="282"/>
            <end position="462"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="35"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00083333"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51192"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD63139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="F56D2.6b"/>
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    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="G8JY03"/>
        </source>
    </evidence>
    <sequence length="700" mass="79818" checksum="7A05351F331BE9B1" modified="2012-01-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-01-25" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G8JY06</accession>
    <name>G8JY06_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">set-1</name>
        <name evidence="2" type="ORF">CELE_T26A5.7</name>
        <name evidence="4" type="ORF">T26A5.7</name>
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    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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    <dbReference type="AGR" id="WB:WBGene00004781"/>
    <dbReference type="CTD" id="175918"/>
    <dbReference type="WormBase" id="T26A5.7b">
        <property type="protein sequence ID" value="CE34599"/>
        <property type="gene ID" value="WBGene00004781"/>
        <property type="gene designation" value="set-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047978_2_1_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004781">
        <property type="expression patterns" value="Expressed in embryo and 9 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G8JY06">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
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        <property type="evidence" value="ECO:0000315"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KMT5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167:SF1">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T26A5.7b"/>
        </source>
    </evidence>
    <sequence length="105" mass="12301" checksum="4241BA9A0D5AA807" modified="2012-01-25" version="1">MEYSEAKVIEEQYSNDEEIGSYMYFFEHNNKKWCIDATKESPWKGRLINHSVLRPNLKTKVVEIDGSHHLILVARRQIAQGEELLYDYGDRSAETIAKNPWLVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H8P172</accession>
    <name>H8P172_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polycomb protein sop-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">sop-2</name>
        <name evidence="4" type="ORF">C50E10.4</name>
        <name evidence="2" type="ORF">CELE_C50E10.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
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    </dbReference>
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    <dbReference type="PeptideAtlas" id="H8P172"/>
    <dbReference type="GeneID" id="174874"/>
    <dbReference type="AGR" id="WB:WBGene00004945"/>
    <dbReference type="CTD" id="174874"/>
    <dbReference type="WormBase" id="C50E10.4b">
        <property type="protein sequence ID" value="CE47166"/>
        <property type="gene ID" value="WBGene00004945"/>
        <property type="gene designation" value="sop-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022573_0_0_1"/>
    <dbReference type="OMA" id="ENNHEAT"/>
    <dbReference type="OrthoDB" id="5911739at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004945">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8P172">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="P:axon guidance"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010607">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="WormBase"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell migration"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="project" value="WormBase"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="288"/>
        </location>
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        <location>
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            <end position="536"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
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        </location>
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        <location>
            <begin position="317"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
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        <location>
            <begin position="452"/>
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        </location>
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        <location>
            <begin position="473"/>
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        </location>
    </feature>
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        <location>
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            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C50E10.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H8P172"/>
        </source>
    </evidence>
    <sequence length="737" mass="81089" checksum="2EF22C81A8DB0A43" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H8P173</accession>
    <name>H8P173_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">sop-2</name>
        <name evidence="4" type="ORF">C50E10.4</name>
        <name evidence="2" type="ORF">CELE_C50E10.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCG28196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254342.1">
        <property type="nucleotide sequence ID" value="NM_001267413.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H8P173"/>
    <dbReference type="PeptideAtlas" id="H8P173"/>
    <dbReference type="GeneID" id="174874"/>
    <dbReference type="AGR" id="WB:WBGene00004945"/>
    <dbReference type="CTD" id="174874"/>
    <dbReference type="WormBase" id="C50E10.4c">
        <property type="protein sequence ID" value="CE47133"/>
        <property type="gene ID" value="WBGene00004945"/>
        <property type="gene designation" value="sop-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022573_0_0_1"/>
    <dbReference type="OrthoDB" id="5911739at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004945">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="H8P173">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010607">
        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040015">
        <property type="term" value="P:negative regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048665">
        <property type="term" value="P:neuron fate specification"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042659">
        <property type="term" value="P:regulation of cell fate specification"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040034">
        <property type="term" value="P:regulation of development, heterochronic"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCG28196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C50E10.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="H8P173"/>
        </source>
    </evidence>
    <sequence length="509" mass="55082" checksum="6D2A18EAA5AAFEA6" modified="2012-05-16" version="1">MAARRGGRPGYRGAFRGAARGAPSRRPAPAAEVAPETPVAAPMAPAAPAAPATPEAAPAAEVMDTSIATEMPQESAVDLSNVSAATEMDTSKEGEASRPTSEKKKFQKIRTTEMDRLMSMDLGPKDGGRVGELGHMWPESRRRPAAPLPETPAAQPRKSLPRRAAEKKKPEDSDAAEEQEVEMEVDNDASTSTPRNARGGRGGGNRRGSRRGQKRTSGGSGKLVEPKKEPVDEPAEKIPKRSEAAPEVPATATTKEAPPSTSSSPPDAPATPATPASSDSRDSPRKIRAMIFSLTGSPPESETPPVLQQEQVISTAAPTAGRHPNIIQQVPHINRIPPQPLRRLTAPQAPPASQPEEPPVQQTVPVVKVELASAPAPIVRDPQSTEPVPPAMPTLVENNHEATLILPPNKTSDYTRWNAQDLINWVRLLITNNVDSTIAIMVREEFDGETLACLVLDDDFRKEVPIPYGHYKKMKIYGTEVLNHYRTEKYQADLRKFHEELAAWKAQQR</sequence>
</entry>
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    <accession>O01700-2</accession>
    <name>DLK1_CAEEL</name>
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        <recommendedName>
            <fullName evidence="1">Isoform b of Mitogen-activated protein kinase kinase kinase dlk-1</fullName>
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            <fullName>DAP kinase-like kinase</fullName>
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        <alternativeName>
            <fullName>Death-associated protein kinase-like kinase</fullName>
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    <gene>
        <name type="primary">dlk-1</name>
        <name type="ORF">F33E2.2</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2005" name="Cell" volume="120" first="407" last="420">
            <title>Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development.</title>
            <authorList>
                <person name="Nakata K."/>
                <person name="Abrams B."/>
                <person name="Grill B."/>
                <person name="Goncharov A."/>
                <person name="Huang X."/>
                <person name="Chisholm A.D."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="15707898"/>
            <dbReference type="DOI" id="10.1016/j.cell.2004.12.017"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>UBIQUITINATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2007" name="Neuron" volume="55" first="587" last="601">
            <title>C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1.</title>
            <authorList>
                <person name="Grill B."/>
                <person name="Bienvenut W.V."/>
                <person name="Brown H.M."/>
                <person name="Ackley B.D."/>
                <person name="Quadroni M."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="17698012"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2007.07.009"/>
        </citation>
        <scope>ACTIVITY REGULATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2008" name="Dev. Dyn." volume="237" first="630" last="639">
            <title>Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions.</title>
            <authorList>
                <person name="Abrams B."/>
                <person name="Grill B."/>
                <person name="Huang X."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="18224716"/>
            <dbReference type="DOI" id="10.1002/dvdy.21446"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2009" name="Cell" volume="138" first="1005" last="1018">
            <title>The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.</title>
            <authorList>
                <person name="Yan D."/>
                <person name="Wu Z."/>
                <person name="Chisholm A.D."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="19737525"/>
            <dbReference type="DOI" id="10.1016/j.cell.2009.06.023"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Science" volume="323" first="802" last="806">
            <title>Axon regeneration requires a conserved MAP kinase pathway.</title>
            <authorList>
                <person name="Hammarlund M."/>
                <person name="Nix P."/>
                <person name="Hauth L."/>
                <person name="Jorgensen E.M."/>
                <person name="Bastiani M."/>
            </authorList>
            <dbReference type="PubMed" id="19164707"/>
            <dbReference type="DOI" id="10.1126/science.1165527"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="7">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="3982" last="3987">
            <title>Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway.</title>
            <authorList>
                <person name="Bounoutas A."/>
                <person name="Kratz J."/>
                <person name="Emtage L."/>
                <person name="Ma C."/>
                <person name="Nguyen K.C."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="21368137"/>
            <dbReference type="DOI" id="10.1073/pnas.1101360108"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-144; 166-GLN--ILE-928; 181-GLN--ILE-928; ASP-246 AND GLY-308</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2012" name="Dev. Cell" volume="23" first="716" last="728">
            <title>Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration.</title>
            <authorList>
                <person name="Ghosh-Roy A."/>
                <person name="Goncharov A."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="23000142"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2012.08.010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="Neuron" volume="76" first="534" last="548">
            <title>Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform.</title>
            <authorList>
                <person name="Yan D."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="23141066"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2012.08.043"/>
        </citation>
        <scope>FUNCTION (ISOFORMS A AND C)</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION (ISOFORMS A AND C)</scope>
        <scope>ALTERNATIVE POLYADENYLATION</scope>
        <scope>DOMAIN</scope>
        <scope>MOTIF</scope>
        <scope>PHOSPHORYLATION AT SER-874 AND SER-878</scope>
        <scope>MUTAGENESIS OF 312-TRP--ILE-928; ARG-363; 449-LEU--LEU-480; LEU-459; 605-SER--ASP-814; 523-ARG--ILE-928; 631-GLY--ILE-928; 816-ARG--ILE-928; GLY-870; SER-874; SER-878 AND 874-SER--ASP-879</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2015" name="Genes Dev." volume="29" first="2377" last="2390">
            <title>Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development.</title>
            <authorList>
                <person name="Chen F."/>
                <person name="Zhou Y."/>
                <person name="Qi Y.B."/>
                <person name="Khivansara V."/>
                <person name="Li H."/>
                <person name="Chun S.Y."/>
                <person name="Kim J.K."/>
                <person name="Fu X.D."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="26588990"/>
            <dbReference type="DOI" id="10.1101/gad.266650.115"/>
        </citation>
        <scope>ALTERNATIVE POLYADENYLATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005733" last="E1005733">
            <title>DLK-1/p38 MAP Kinase signaling controls cilium length by regulating RAB-5 mediated endocytosis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="van der Vaart A."/>
                <person name="Rademakers S."/>
                <person name="Jansen G."/>
            </authorList>
            <dbReference type="PubMed" id="26657059"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005733"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006010" last="E1006010">
            <title>The MADD-3 LAMMER kinase interacts with a p38 MAP kinase pathway to regulate the display of the EVA-1 guidance receptor in Caenorhabditis elegans.</title>
            <authorList>
                <person name="D'Souza S.A."/>
                <person name="Rajendran L."/>
                <person name="Bagg R."/>
                <person name="Barbier L."/>
                <person name="van Pel D.M."/>
                <person name="Moshiri H."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="27123983"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O01700-4</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_052964"/>
        </isoform>
        <isoform>
            <id>O01700-1</id>
            <name evidence="5">a</name>
            <name evidence="2">DLK-1L</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O01700-3</id>
            <name evidence="7">c</name>
            <name evidence="2">DLK-1S</name>
            <sequence type="described" ref="VSP_052965 VSP_052966"/>
        </isoform>
        <isoform>
            <id>O01700-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_052967"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001021444.1">
        <property type="nucleotide sequence ID" value="NM_001026273.7"/>
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    <dbReference type="WormBase" id="F33E2.2b">
        <property type="protein sequence ID" value="CE36154"/>
        <property type="gene ID" value="WBGene00001008"/>
        <property type="gene designation" value="dlk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O43283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="23141066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAB06544.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F33E2.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F33E2.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F33E2.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="F33E2.2d"/>
        </source>
    </evidence>
    <sequence length="921" mass="102824" checksum="302577E5324813B4" modified="2004-07-05" version="4"> </sequence>
</entry>
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    <accession>O01700-3</accession>
    <name>DLK1_CAEEL</name>
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        <recommendedName>
            <fullName evidence="1">Isoform c of Mitogen-activated protein kinase kinase kinase dlk-1</fullName>
            <ecNumber evidence="1">2.7.11.25</ecNumber>
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        <alternativeName>
            <fullName>DAP kinase-like kinase</fullName>
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        <alternativeName>
            <fullName>Death-associated protein kinase-like kinase</fullName>
        </alternativeName>
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    <gene>
        <name type="primary">dlk-1</name>
        <name type="ORF">F33E2.2</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="6">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2005" name="Cell" volume="120" first="407" last="420">
            <title>Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development.</title>
            <authorList>
                <person name="Nakata K."/>
                <person name="Abrams B."/>
                <person name="Grill B."/>
                <person name="Goncharov A."/>
                <person name="Huang X."/>
                <person name="Chisholm A.D."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="15707898"/>
            <dbReference type="DOI" id="10.1016/j.cell.2004.12.017"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>UBIQUITINATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2007" name="Neuron" volume="55" first="587" last="601">
            <title>C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1.</title>
            <authorList>
                <person name="Grill B."/>
                <person name="Bienvenut W.V."/>
                <person name="Brown H.M."/>
                <person name="Ackley B.D."/>
                <person name="Quadroni M."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="17698012"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2007.07.009"/>
        </citation>
        <scope>ACTIVITY REGULATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2008" name="Dev. Dyn." volume="237" first="630" last="639">
            <title>Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions.</title>
            <authorList>
                <person name="Abrams B."/>
                <person name="Grill B."/>
                <person name="Huang X."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="18224716"/>
            <dbReference type="DOI" id="10.1002/dvdy.21446"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2009" name="Cell" volume="138" first="1005" last="1018">
            <title>The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.</title>
            <authorList>
                <person name="Yan D."/>
                <person name="Wu Z."/>
                <person name="Chisholm A.D."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="19737525"/>
            <dbReference type="DOI" id="10.1016/j.cell.2009.06.023"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Science" volume="323" first="802" last="806">
            <title>Axon regeneration requires a conserved MAP kinase pathway.</title>
            <authorList>
                <person name="Hammarlund M."/>
                <person name="Nix P."/>
                <person name="Hauth L."/>
                <person name="Jorgensen E.M."/>
                <person name="Bastiani M."/>
            </authorList>
            <dbReference type="PubMed" id="19164707"/>
            <dbReference type="DOI" id="10.1126/science.1165527"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="5" key="7">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="3982" last="3987">
            <title>Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway.</title>
            <authorList>
                <person name="Bounoutas A."/>
                <person name="Kratz J."/>
                <person name="Emtage L."/>
                <person name="Ma C."/>
                <person name="Nguyen K.C."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="21368137"/>
            <dbReference type="DOI" id="10.1073/pnas.1101360108"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-144; 166-GLN--ILE-928; 181-GLN--ILE-928; ASP-246 AND GLY-308</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2012" name="Dev. Cell" volume="23" first="716" last="728">
            <title>Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration.</title>
            <authorList>
                <person name="Ghosh-Roy A."/>
                <person name="Goncharov A."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="23000142"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2012.08.010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="Neuron" volume="76" first="534" last="548">
            <title>Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform.</title>
            <authorList>
                <person name="Yan D."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="23141066"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2012.08.043"/>
        </citation>
        <scope>FUNCTION (ISOFORMS A AND C)</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION (ISOFORMS A AND C)</scope>
        <scope>ALTERNATIVE POLYADENYLATION</scope>
        <scope>DOMAIN</scope>
        <scope>MOTIF</scope>
        <scope>PHOSPHORYLATION AT SER-874 AND SER-878</scope>
        <scope>MUTAGENESIS OF 312-TRP--ILE-928; ARG-363; 449-LEU--LEU-480; LEU-459; 605-SER--ASP-814; 523-ARG--ILE-928; 631-GLY--ILE-928; 816-ARG--ILE-928; GLY-870; SER-874; SER-878 AND 874-SER--ASP-879</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2015" name="Genes Dev." volume="29" first="2377" last="2390">
            <title>Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development.</title>
            <authorList>
                <person name="Chen F."/>
                <person name="Zhou Y."/>
                <person name="Qi Y.B."/>
                <person name="Khivansara V."/>
                <person name="Li H."/>
                <person name="Chun S.Y."/>
                <person name="Kim J.K."/>
                <person name="Fu X.D."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="26588990"/>
            <dbReference type="DOI" id="10.1101/gad.266650.115"/>
        </citation>
        <scope>ALTERNATIVE POLYADENYLATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005733" last="E1005733">
            <title>DLK-1/p38 MAP Kinase signaling controls cilium length by regulating RAB-5 mediated endocytosis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="van der Vaart A."/>
                <person name="Rademakers S."/>
                <person name="Jansen G."/>
            </authorList>
            <dbReference type="PubMed" id="26657059"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005733"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006010" last="E1006010">
            <title>The MADD-3 LAMMER kinase interacts with a p38 MAP kinase pathway to regulate the display of the EVA-1 guidance receptor in Caenorhabditis elegans.</title>
            <authorList>
                <person name="D'Souza S.A."/>
                <person name="Rajendran L."/>
                <person name="Bagg R."/>
                <person name="Barbier L."/>
                <person name="van Pel D.M."/>
                <person name="Moshiri H."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="27123983"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">By forming heterooligomers with isoform a, acts as an inhibitor of isoform a activation. Its inhibitory function is independent of its catalytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synapse</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <text evidence="2">Co-localizes with isoform c in synapses and axons; however, localization is dependent of its interaction with isoform a.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O01700-4</id>
            <name evidence="10">d</name>
            <sequence type="described" ref="VSP_052964"/>
        </isoform>
        <isoform>
            <id>O01700-3</id>
            <name evidence="9">c</name>
            <name evidence="4">DLK-1S</name>
            <sequence type="described" ref="VSP_052965 VSP_052966"/>
        </isoform>
        <isoform>
            <id>O01700-1</id>
            <name evidence="7">a</name>
            <name evidence="4">DLK-1L</name>
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        </isoform>
        <isoform>
            <id>O01700-2</id>
            <name evidence="8">b</name>
            <sequence type="described" ref="VSP_052967"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2 3">Produced by alternative polyadenylation. The alternative polyadenylation site is in intron 7. In neurons, the usage of this polyadenylation site is regulated by the antagonist action of sydn-1 and ssup-72.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001021445.1">
        <property type="nucleotide sequence ID" value="NM_001026274.5"/>
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        <property type="protein sequence ID" value="CE36155"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O43283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23141066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="26588990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="23141066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="CAB06544.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F33E2.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="F33E2.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="F33E2.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="F33E2.2d"/>
        </source>
    </evidence>
    <sequence length="577" mass="65401" checksum="BEDDDCCA10DB525A" modified="2004-07-05" version="4"> </sequence>
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<entry dataset="Swiss-Prot" created="2008-11-04" modified="2026-01-28" version="191" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Isoform d of Mitogen-activated protein kinase kinase kinase dlk-1</fullName>
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        <alternativeName>
            <fullName>DAP kinase-like kinase</fullName>
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        <alternativeName>
            <fullName>Death-associated protein kinase-like kinase</fullName>
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        <name type="primary">dlk-1</name>
        <name type="ORF">F33E2.2</name>
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    <organism>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2005" name="Cell" volume="120" first="407" last="420">
            <title>Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development.</title>
            <authorList>
                <person name="Nakata K."/>
                <person name="Abrams B."/>
                <person name="Grill B."/>
                <person name="Goncharov A."/>
                <person name="Huang X."/>
                <person name="Chisholm A.D."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="15707898"/>
            <dbReference type="DOI" id="10.1016/j.cell.2004.12.017"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>UBIQUITINATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2007" name="Neuron" volume="55" first="587" last="601">
            <title>C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1.</title>
            <authorList>
                <person name="Grill B."/>
                <person name="Bienvenut W.V."/>
                <person name="Brown H.M."/>
                <person name="Ackley B.D."/>
                <person name="Quadroni M."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="17698012"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2007.07.009"/>
        </citation>
        <scope>ACTIVITY REGULATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2008" name="Dev. Dyn." volume="237" first="630" last="639">
            <title>Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions.</title>
            <authorList>
                <person name="Abrams B."/>
                <person name="Grill B."/>
                <person name="Huang X."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="18224716"/>
            <dbReference type="DOI" id="10.1002/dvdy.21446"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2009" name="Cell" volume="138" first="1005" last="1018">
            <title>The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.</title>
            <authorList>
                <person name="Yan D."/>
                <person name="Wu Z."/>
                <person name="Chisholm A.D."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="19737525"/>
            <dbReference type="DOI" id="10.1016/j.cell.2009.06.023"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Science" volume="323" first="802" last="806">
            <title>Axon regeneration requires a conserved MAP kinase pathway.</title>
            <authorList>
                <person name="Hammarlund M."/>
                <person name="Nix P."/>
                <person name="Hauth L."/>
                <person name="Jorgensen E.M."/>
                <person name="Bastiani M."/>
            </authorList>
            <dbReference type="PubMed" id="19164707"/>
            <dbReference type="DOI" id="10.1126/science.1165527"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="7">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="3982" last="3987">
            <title>Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway.</title>
            <authorList>
                <person name="Bounoutas A."/>
                <person name="Kratz J."/>
                <person name="Emtage L."/>
                <person name="Ma C."/>
                <person name="Nguyen K.C."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="21368137"/>
            <dbReference type="DOI" id="10.1073/pnas.1101360108"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-144; 166-GLN--ILE-928; 181-GLN--ILE-928; ASP-246 AND GLY-308</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2012" name="Dev. Cell" volume="23" first="716" last="728">
            <title>Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration.</title>
            <authorList>
                <person name="Ghosh-Roy A."/>
                <person name="Goncharov A."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="23000142"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2012.08.010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="Neuron" volume="76" first="534" last="548">
            <title>Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform.</title>
            <authorList>
                <person name="Yan D."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="23141066"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2012.08.043"/>
        </citation>
        <scope>FUNCTION (ISOFORMS A AND C)</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION (ISOFORMS A AND C)</scope>
        <scope>ALTERNATIVE POLYADENYLATION</scope>
        <scope>DOMAIN</scope>
        <scope>MOTIF</scope>
        <scope>PHOSPHORYLATION AT SER-874 AND SER-878</scope>
        <scope>MUTAGENESIS OF 312-TRP--ILE-928; ARG-363; 449-LEU--LEU-480; LEU-459; 605-SER--ASP-814; 523-ARG--ILE-928; 631-GLY--ILE-928; 816-ARG--ILE-928; GLY-870; SER-874; SER-878 AND 874-SER--ASP-879</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2015" name="Genes Dev." volume="29" first="2377" last="2390">
            <title>Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development.</title>
            <authorList>
                <person name="Chen F."/>
                <person name="Zhou Y."/>
                <person name="Qi Y.B."/>
                <person name="Khivansara V."/>
                <person name="Li H."/>
                <person name="Chun S.Y."/>
                <person name="Kim J.K."/>
                <person name="Fu X.D."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="26588990"/>
            <dbReference type="DOI" id="10.1101/gad.266650.115"/>
        </citation>
        <scope>ALTERNATIVE POLYADENYLATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005733" last="E1005733">
            <title>DLK-1/p38 MAP Kinase signaling controls cilium length by regulating RAB-5 mediated endocytosis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="van der Vaart A."/>
                <person name="Rademakers S."/>
                <person name="Jansen G."/>
            </authorList>
            <dbReference type="PubMed" id="26657059"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005733"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006010" last="E1006010">
            <title>The MADD-3 LAMMER kinase interacts with a p38 MAP kinase pathway to regulate the display of the EVA-1 guidance receptor in Caenorhabditis elegans.</title>
            <authorList>
                <person name="D'Souza S.A."/>
                <person name="Rajendran L."/>
                <person name="Bagg R."/>
                <person name="Barbier L."/>
                <person name="van Pel D.M."/>
                <person name="Moshiri H."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="27123983"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O01700-1</id>
            <name evidence="5">a</name>
            <name evidence="2">DLK-1L</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O01700-3</id>
            <name evidence="7">c</name>
            <name evidence="2">DLK-1S</name>
            <sequence type="described" ref="VSP_052966 VSP_052965"/>
        </isoform>
        <isoform>
            <id>O01700-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_052967"/>
        </isoform>
        <isoform>
            <id>O01700-4</id>
            <name evidence="8">d</name>
            <sequence type="described" ref="VSP_052964"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001129769.1">
        <property type="nucleotide sequence ID" value="NM_001136297.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F33E2.2d">
        <property type="protein sequence ID" value="CE23702"/>
        <property type="gene ID" value="WBGene00001008"/>
        <property type="gene designation" value="dlk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O43283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="23141066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAB06544.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F33E2.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F33E2.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F33E2.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="F33E2.2d"/>
        </source>
    </evidence>
    <sequence length="855" mass="95787" checksum="F44DD2538CB7D95A" modified="2004-07-05" version="4"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>O17201</accession>
    <name>O17201_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">fbxa-158</name>
        <name evidence="4" type="ORF">C08E3.10</name>
        <name evidence="2" type="ORF">CELE_C08E3.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD63675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040734.1">
        <property type="nucleotide sequence ID" value="NM_001047269.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O17201"/>
    <dbReference type="SMR" id="O17201"/>
    <dbReference type="GeneID" id="182402"/>
    <dbReference type="AGR" id="WB:WBGene00015602"/>
    <dbReference type="CTD" id="182402"/>
    <dbReference type="WormBase" id="C08E3.10b">
        <property type="protein sequence ID" value="CE39672"/>
        <property type="gene ID" value="WBGene00015602"/>
        <property type="gene designation" value="fbxa-158"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030831_3_2_1"/>
    <dbReference type="OrthoDB" id="616263at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015602">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O17201">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd22150">
        <property type="entry name" value="F-box_CeFBXA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002900">
        <property type="entry name" value="DUF38/FTH_CAE_spp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040161">
        <property type="entry name" value="FB224"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23015:SF4">
        <property type="entry name" value="DUF38 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23015">
        <property type="entry name" value="UNCHARACTERIZED C.ELEGANS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01827">
        <property type="entry name" value="FTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C08E3.10b"/>
        </source>
    </evidence>
    <sequence length="352" mass="41517" checksum="16B579129796D355" modified="2012-01-25" version="3">MTQYDFDFWFYRFYHGNHDLLYDRSADPVPKSLPNMPLNIISEILAHLDIMDLLVMMKVSRNLRSVVQAKVDVVDSIGVRFFEGKNAKIVYNDRFIITYEPKGGGCTVIYFDSYVNEDDYFLEEYDERSNKKEIFVPGKDYLELFNKDLKCLLENRKIQLETIEFTFGTGKELCEKCMNGIVEALKSAKSLTSRTVRIWPFSFSELAQLVAFFPAETLEEIYFAGEKDTGFEQLVSLDQWKNARKFDADGKLSVPIEHFLHFEWFEVCLATFTESDAMKIRDMIDRSTHFGHAEIRSKDMNISELMRVFAAHNQNQNFAYETPDKRFFNVKIYSYLFRITKLSYRYDYNDWL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-02-26" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>O17907-2</accession>
    <name>CTG1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Protein ctg-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ctg-1</name>
        <name evidence="3" type="ORF">H06O01.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2016" name="Elife" volume="5" first="0" last="0">
            <title>Boundary cells restrict dystroglycan trafficking to control basement membrane sliding during tissue remodeling.</title>
            <authorList>
                <person name="McClatchey S.T."/>
                <person name="Wang Z."/>
                <person name="Linden L.M."/>
                <person name="Hastie E.L."/>
                <person name="Wang L."/>
                <person name="Shen W."/>
                <person name="Chen A."/>
                <person name="Chi Q."/>
                <person name="Sherwood D.R."/>
            </authorList>
            <dbReference type="PubMed" id="27661254"/>
            <dbReference type="DOI" id="10.7554/elife.17218"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O17907-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O17907-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060470"/>
        </isoform>
        <isoform>
            <id>O17907-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060471"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001263451.1">
        <property type="nucleotide sequence ID" value="NM_001276522.3"/>
    </dbReference>
    <dbReference type="WormBase" id="H06O01.3b">
        <property type="protein sequence ID" value="CE48027"/>
        <property type="gene ID" value="WBGene00010370"/>
        <property type="gene designation" value="ctg-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="H06O01.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="H06O01.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="H06O01.3c"/>
        </source>
    </evidence>
    <sequence length="288" mass="32950" checksum="CB202C056AD1F2C0" modified="1998-08-01" version="2">MSLLGNVDVEGLLRSVASLDYIKFSLAAIEKGMKLCEEKAKESGRPFEQMTLVFDLENITSAHFSCKQFASSFTTLVSLFQDHYPLFLRKILIIRAPEMARIAYASITAILQDPITRLVEMPSESDWKWSLAQIVNLDAWPMYWGGNLVENGDPKCPSRIKYGGGAVDESYFVDPKKAMADYDQLTTVYAGDKHLIQIKVKRPSRISWTYMTDEDDIGFEIHYDKTGSCDKLTEMETVYPYIRLECTNVPITGHLDVTDVGNYVLEFDNYYSWFSAKQLRYNIEIEDL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-02-26" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>O17907-3</accession>
    <name>CTG1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Protein ctg-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ctg-1</name>
        <name evidence="3" type="ORF">H06O01.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2016" name="Elife" volume="5" first="0" last="0">
            <title>Boundary cells restrict dystroglycan trafficking to control basement membrane sliding during tissue remodeling.</title>
            <authorList>
                <person name="McClatchey S.T."/>
                <person name="Wang Z."/>
                <person name="Linden L.M."/>
                <person name="Hastie E.L."/>
                <person name="Wang L."/>
                <person name="Shen W."/>
                <person name="Chen A."/>
                <person name="Chi Q."/>
                <person name="Sherwood D.R."/>
            </authorList>
            <dbReference type="PubMed" id="27661254"/>
            <dbReference type="DOI" id="10.7554/elife.17218"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O17907-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060471"/>
        </isoform>
        <isoform>
            <id>O17907-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O17907-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060470"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001263452.1">
        <property type="nucleotide sequence ID" value="NM_001276523.3"/>
    </dbReference>
    <dbReference type="WormBase" id="H06O01.3c">
        <property type="protein sequence ID" value="CE47872"/>
        <property type="gene ID" value="WBGene00010370"/>
        <property type="gene designation" value="ctg-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="H06O01.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="H06O01.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="H06O01.3c"/>
        </source>
    </evidence>
    <sequence length="239" mass="27565" checksum="022F1A31034C079C" modified="1998-08-01" version="2">MTLVFDLENITSAHFSCKQFASSFTTLVSLFQDHYPLFLRKILIIRAPEMARIAYASITAILQDPITRLVEMPSESDWKWSLAQIVNLDAWPMYWGGNLVENGDPKCPSRIKYGGGAVDESYFVDPKKAMADYDQLTTVYAGDKHLIQIKVKRPSRISWTYMTDEDDIGFEIHYDKTGSCDKLTEMETVYPYIRLECTNVPITGHLDVTDVGNYVLEFDNYYSWFSAKQLRYNIEIEDL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1989-07-01" modified="2026-01-28" version="190" xmlns="https://uniprot.org/uniprot">
    <accession>P10567-2</accession>
    <name>MYSP_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Paramyosin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Uncoordinated protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">unc-15</name>
        <name type="ORF">F07A5.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1989" name="J. Mol. Biol." volume="207" first="311" last="333">
            <title>Paramyosin gene (unc-15) of Caenorhabditis elegans. Molecular cloning, nucleotide sequence and models for thick filament structure.</title>
            <authorList>
                <person name="Kagawa H."/>
                <person name="Gengyo K."/>
                <person name="McLachlan A.D."/>
                <person name="Brenner S."/>
                <person name="Karn J."/>
            </authorList>
            <dbReference type="PubMed" id="2754728"/>
            <dbReference type="DOI" id="10.1016/0022-2836(89)90257-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PARTIAL PROTEIN SEQUENCE</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1989" name="J. Mol. Biol." volume="207" first="451" last="454">
            <title>Phosphorylation of the N-terminal region of Caenorhabditis elegans paramyosin.</title>
            <authorList>
                <person name="Schriefer L.A."/>
                <person name="Waterston R.H."/>
            </authorList>
            <dbReference type="PubMed" id="2754733"/>
            <dbReference type="DOI" id="10.1016/0022-2836(89)90267-2"/>
        </citation>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1990" name="J. Mol. Biol." volume="211" first="665" last="665">
            <authorList>
                <person name="Kagawa H."/>
                <person name="Gengyo K."/>
                <person name="McLachlan A.D."/>
                <person name="Brenner S."/>
                <person name="Karn J."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:2754728</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Dev. Dyn." volume="236" first="1093" last="1105">
            <title>Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.</title>
            <authorList>
                <person name="Ono K."/>
                <person name="Yu R."/>
                <person name="Ono S."/>
            </authorList>
            <dbReference type="PubMed" id="17326220"/>
            <dbReference type="DOI" id="10.1002/dvdy.21091"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2016" name="Mol. Biol. Cell" volume="27" first="1606" last="1620">
            <title>The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.</title>
            <authorList>
                <person name="Qadota H."/>
                <person name="Mayans O."/>
                <person name="Matsunaga Y."/>
                <person name="McMurry J.L."/>
                <person name="Wilson K.J."/>
                <person name="Kwon G.E."/>
                <person name="Stanford R."/>
                <person name="Deehan K."/>
                <person name="Tinley T.L."/>
                <person name="Ngwa V.M."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="27009202"/>
            <dbReference type="DOI" id="10.1091/mbc.E15-09-0675"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH UNC-89</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>REGION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006010" last="E1006010">
            <title>The MADD-3 LAMMER kinase interacts with a p38 MAP kinase pathway to regulate the display of the EVA-1 guidance receptor in Caenorhabditis elegans.</title>
            <authorList>
                <person name="D'Souza S.A."/>
                <person name="Rajendran L."/>
                <person name="Bagg R."/>
                <person name="Barbier L."/>
                <person name="van Pel D.M."/>
                <person name="Moshiri H."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="27123983"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P10567-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P10567-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_058762"/>
        </isoform>
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    <dbReference type="RefSeq" id="NP_001367193.1">
        <property type="nucleotide sequence ID" value="NM_001380695.1"/>
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    <dbReference type="WormBase" id="F07A5.7b">
        <property type="protein sequence ID" value="CE42754"/>
        <property type="gene ID" value="WBGene00006754"/>
        <property type="gene designation" value="unc-15"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="F07A5.7a"/>
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    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F07A5.7b"/>
        </source>
    </evidence>
    <sequence length="553" mass="63702" checksum="043B3F8FC8167168" modified="2017-02-15" version="2"> </sequence>
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<entry dataset="TrEMBL" created="1997-05-01" modified="2025-10-08" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>P90862</accession>
    <name>P90862_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH_hydro domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">CELE_F36A2.9</name>
        <name evidence="3 5" type="ORF">F36A2.9</name>
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    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB03072.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21835">
        <property type="entry name" value="T21835"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_492385.2">
        <property type="nucleotide sequence ID" value="NM_059984.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P90862"/>
    <dbReference type="DIP" id="DIP-26503N"/>
    <dbReference type="PeptideAtlas" id="P90862"/>
    <dbReference type="GeneID" id="172695"/>
    <dbReference type="KEGG" id="cel:CELE_F36A2.9"/>
    <dbReference type="UCSC" id="F36A2.9b">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00009456"/>
    <dbReference type="CTD" id="172695"/>
    <dbReference type="WormBase" id="F36A2.9a">
        <property type="protein sequence ID" value="CE32407"/>
        <property type="gene ID" value="WBGene00009456"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497174_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
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    <dbReference type="Bgee" id="WBGene00009456">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="P90862">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
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    <dbReference type="CDD" id="cd01824">
        <property type="entry name" value="Phospholipase_B_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035547">
        <property type="entry name" value="Phospholipase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
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        <property type="entry name" value="LIPASE_GDSL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
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            <begin position="1"/>
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            <begin position="17"/>
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        <location>
            <begin position="48"/>
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            <begin position="52"/>
            <end position="73"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="87"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB03072.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F36A2.9a"/>
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    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="P90862"/>
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    </evidence>
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        <submittedName>
            <fullName evidence="2">Cadherin_C domain-containing protein</fullName>
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        <name evidence="2" type="ORF">CELE_F46F3.3</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB03113.2"/>
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    <dbReference type="PIR" id="T22314">
        <property type="entry name" value="T22314"/>
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    <dbReference type="RefSeq" id="NP_001256352.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="P90877"/>
    <dbReference type="GeneID" id="185854"/>
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        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00009791"/>
    <dbReference type="CTD" id="185854"/>
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        <property type="protein sequence ID" value="CE39576"/>
        <property type="gene ID" value="WBGene00009791"/>
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    <dbReference type="HOGENOM" id="CLU_1705844_0_0_1"/>
    <dbReference type="OrthoDB" id="5850842at2759"/>
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        <property type="component" value="Chromosome V"/>
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    <dbReference type="Bgee" id="WBGene00009791">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="P90877">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB03113.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F46F3.3a"/>
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    </evidence>
    <sequence length="126" mass="13812" checksum="5B78FDE3079CF58F" modified="2006-02-21" version="2">MVDNEWMDKFIPREYKRTHSLSGSDEQDVTKDNNFGYSEQGMKDLDEVGGLVGGGDSDLLGILRPYYSMVEMTANGNKQGMGQYLHVLPDSSEGDTPIYSVGGSMYGGVEPAGAKLGYMNRPFGKR</sequence>
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        <submittedName>
            <fullName evidence="3">GST C-terminal domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">CELE_F55A11.6</name>
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    <organism evidence="3 4">
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Peloderinae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
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    <dbReference type="EMBL" id="BX284605">
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        <property type="entry name" value="T22691"/>
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    <dbReference type="RefSeq" id="NP_001041123.2">
        <property type="nucleotide sequence ID" value="NM_001047658.2"/>
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    <dbReference type="AlphaFoldDB" id="P90887"/>
    <dbReference type="SMR" id="P90887"/>
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    <dbReference type="KEGG" id="cel:CELE_F55A11.6"/>
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        <property type="organism name" value="c. elegans"/>
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        <property type="protein sequence ID" value="CE40966"/>
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        <property type="component" value="Chromosome V"/>
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    <dbReference type="Bgee" id="WBGene00010079">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Protein CBG23268"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF256">
        <property type="entry name" value="GST C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="61"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="138"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA96662.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F55A11.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="P90887"/>
        </source>
    </evidence>
    <sequence length="269" mass="31332" checksum="0DF1E0D655C6C846" modified="2007-06-26" version="3">MTPSLALQYSITYALSPKFVKSSSSGRHLSVSVSSTTQKNFPSPVQSRKNKMDTMHGFLVPTYTLHDFDDGEECKVVRMIFQMSRVPYEFKHVHRDDYILEDYPFYALPTLEMNERKYGSVLSICRHLAWRYNLSGKTAYDDAQVDDIAEKVFEVRMKIKNWIDHIEHAADHACDEECTEEIAPRILTNTLFPCLERMLKSAASCWLVGHTMTWVDLLVACLVNPIIYHRPKLLQDFPLLYLHNEKVAHHDDLVGFLYHVRTRKFQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-05-01" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>P90899</accession>
    <name>P90899_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SPX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F59B8.1</name>
        <name evidence="1 3" type="ORF">F59B8.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA92779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T22984">
        <property type="entry name" value="T22984"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023249.1">
        <property type="nucleotide sequence ID" value="NM_001028078.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P90899"/>
    <dbReference type="SMR" id="P90899"/>
    <dbReference type="PeptideAtlas" id="P90899"/>
    <dbReference type="GeneID" id="177774"/>
    <dbReference type="UCSC" id="F59B8.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010316"/>
    <dbReference type="CTD" id="177774"/>
    <dbReference type="WormBase" id="F59B8.1b">
        <property type="protein sequence ID" value="CE11454"/>
        <property type="gene ID" value="WBGene00010316"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076202_0_0_1"/>
    <dbReference type="OrthoDB" id="10052054at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010316">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="P90899">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21010">
        <property type="entry name" value="AGAP001581-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21010:SF3">
        <property type="entry name" value="DAXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA92779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F59B8.1b"/>
        </source>
    </evidence>
    <sequence length="213" mass="24843" checksum="3F79E4DB2E246B8B" modified="1997-05-01" version="1">MFRTAETSRDTLITTAYRLHRTRWRILEPYRRLKNALKKLQEDYLKSKEANALMRYVKLGQSVREVAMLEKQYWKLLNIPAQEGTEDANCYVVKIIELLEDTPTQLPPTRGIGALLQSTIGKPAEANVDTVLHDSLKARKSEDLVKECEGLYAQLYRLTKKYLGLRRLIKELHDKYEATRMFPIVPRYAMLKKMIKATLRAPEFADICHEQTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="168" xmlns="https://uniprot.org/uniprot">
    <accession>Q20624-2</accession>
    <name>MOCS1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform a of Molybdenum cofactor biosynthesis protein moc-5</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName>GTP 3',8-cyclase</fullName>
                <ecNumber evidence="1">4.1.99.22</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">MOCS1A</fullName>
            </alternativeName>
            <alternativeName>
                <fullName>Molybdenum cofactor biosynthesis protein A</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>Cyclic pyranopterin monophosphate synthase</fullName>
                <ecNumber evidence="2">4.6.1.17</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">MOCS1B</fullName>
            </alternativeName>
            <alternativeName>
                <fullName>Molybdenum cofactor biosynthesis protein C</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="5" type="primary">moc-5</name>
        <name evidence="5" type="ORF">F49E2.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably forms a complex with isoform b that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP) (By similarity). Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q20624-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_060750"/>
        </isoform>
        <isoform>
            <id>Q20624-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_011903 VSP_011904"/>
        </isoform>
        <isoform>
            <id>Q20624-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_060752 VSP_060751"/>
        </isoform>
        <isoform>
            <id>Q20624-1</id>
            <name evidence="5">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="1"/>
    <dbReference type="EC" id="4.6.1.17" evidence="2"/>
    <dbReference type="RefSeq" id="NP_509611.3">
        <property type="nucleotide sequence ID" value="NM_077210.5"/>
    </dbReference>
    <dbReference type="WormBase" id="F49E2.1a">
        <property type="protein sequence ID" value="CE27759"/>
        <property type="gene ID" value="WBGene00009885"/>
        <property type="gene designation" value="moc-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P69848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9NZB8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F49E2.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F49E2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F49E2.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F49E2.1d"/>
        </source>
    </evidence>
    <sequence length="389" mass="44285" checksum="4D5BD4E0D2808871" modified="2004-11-23" version="3">MSCRAGKKLFQWSRVKSSTEEIVKQLTVPLREHAEPILTLTPEQKREAVRLKIQEIEHTKGQPPFFDMFMREHTYLRISLTEKCNFRCLYCMPAEGVPLKPKDKMLSNSEVLRLVKLFAAHGVDKVRLTGGEPTIRKDIVHIVEGISSTPGIKEVGITTNGLVLQRFLPQLRDAGLTKINISIDSLDREKFAKMTRRDGFDKVWKAIELARGYYPKVKLNVVVLKHQNENEVVDFVNLTKDRNLDVRFIEFMPFGGNEFKNDNFIGYREMLNLIVDKYGDGVIRLSDSPNDTTKAYKIDGFQGQFGFITSMSDHFCNTCNRLRITADGNLKVCLHGNSEVSLRDRIRCGDSDEQLSEVIQKAVNNKKARHAGMDALKNLPNRPMILIGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="168" xmlns="https://uniprot.org/uniprot">
    <accession>Q20624-3</accession>
    <name>MOCS1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform c of Molybdenum cofactor biosynthesis protein moc-5</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName>GTP 3',8-cyclase</fullName>
                <ecNumber evidence="1">4.1.99.22</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">MOCS1A</fullName>
            </alternativeName>
            <alternativeName>
                <fullName>Molybdenum cofactor biosynthesis protein A</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>Cyclic pyranopterin monophosphate synthase</fullName>
                <ecNumber evidence="2">4.6.1.17</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">MOCS1B</fullName>
            </alternativeName>
            <alternativeName>
                <fullName>Molybdenum cofactor biosynthesis protein C</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="5" type="primary">moc-5</name>
        <name evidence="5" type="ORF">F49E2.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q20624-1</id>
            <name evidence="5">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q20624-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_060750"/>
        </isoform>
        <isoform>
            <id>Q20624-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_060752 VSP_060751"/>
        </isoform>
        <isoform>
            <id>Q20624-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_011903 VSP_011904"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="1"/>
    <dbReference type="EC" id="4.6.1.17" evidence="2"/>
    <dbReference type="RefSeq" id="NP_001343868.1">
        <property type="nucleotide sequence ID" value="NM_001356794.4"/>
    </dbReference>
    <dbReference type="WormBase" id="F49E2.1c">
        <property type="protein sequence ID" value="CE52186"/>
        <property type="gene ID" value="WBGene00009885"/>
        <property type="gene designation" value="moc-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P69848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9NZB8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F49E2.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F49E2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F49E2.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F49E2.1d"/>
        </source>
    </evidence>
    <sequence length="492" mass="56009" checksum="6383412E94FF8711" modified="2004-11-23" version="3">MSCRAGKKLFQWSRVKSSTEEIVKQLTVPLREHAEPILTLTPEQKREAVRLKIQEIEHTKGQPPFFDMFMREHTYLRISLTEKCNFRCLYCMPAEGVPLKPKDKMLSNSEVLRLVKLFAAHGVDKVRLTGGEPTIRKDIVHIVEGISSTPGIKEVGITTNGLVLQRFLPQLRDAGLTKINISIDSLDREKFAKMTRRDGFDKVWKAIELARGYYPKVKLNVVVLKHQNENEVVDFVNLTKDRNLDVRFIEFMPFGGNEFKNDNFIGYREMLNLIVDKYGDGVIRLSDSPNDTTKAYKIDGFQGQFGFITSMSDHFCNTCNRLRITADGNLKVCLHGNSEVSLRDRIRCGDSDEQLSEVIQKAVNNKKARHAVFRNGRSEEPAKSSNDSYRGLTPVTSASSILVHLPSSSLYHSHLHSSRHFFISQIRCFSTTYSVSSITHLLTHVDNNGNAKQVDVSQKDTSTRTAVARGTIIVSFSTNYEIMLIWNKFFYF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="168" xmlns="https://uniprot.org/uniprot">
    <accession>Q20624-4</accession>
    <name>MOCS1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform d of Molybdenum cofactor biosynthesis protein moc-5</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName>GTP 3',8-cyclase</fullName>
                <ecNumber evidence="1">4.1.99.22</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">MOCS1A</fullName>
            </alternativeName>
            <alternativeName>
                <fullName>Molybdenum cofactor biosynthesis protein A</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>Cyclic pyranopterin monophosphate synthase</fullName>
                <ecNumber evidence="2">4.6.1.17</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">MOCS1B</fullName>
            </alternativeName>
            <alternativeName>
                <fullName>Molybdenum cofactor biosynthesis protein C</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="5" type="primary">moc-5</name>
        <name evidence="5" type="ORF">F49E2.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q20624-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_060752 VSP_060751"/>
        </isoform>
        <isoform>
            <id>Q20624-1</id>
            <name evidence="5">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q20624-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_060750"/>
        </isoform>
        <isoform>
            <id>Q20624-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_011904 VSP_011903"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="1"/>
    <dbReference type="EC" id="4.6.1.17" evidence="2"/>
    <dbReference type="RefSeq" id="NP_001380230.1">
        <property type="nucleotide sequence ID" value="NM_001392824.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F49E2.1d">
        <property type="protein sequence ID" value="CE52073"/>
        <property type="gene ID" value="WBGene00009885"/>
        <property type="gene designation" value="moc-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P69848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9NZB8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F49E2.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F49E2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F49E2.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F49E2.1d"/>
        </source>
    </evidence>
    <sequence length="50" mass="5586" checksum="CA298DA6D1A6799D" modified="2004-11-23" version="3">MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGKTTYTIDNENQI</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q22234</accession>
    <name>Q22234_CAEEL</name>
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        <submittedName>
            <fullName evidence="6">CLaudin-like in Caenorhabditis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">clc-9</name>
        <name evidence="6" type="ORF">CELE_T05E11.2</name>
        <name evidence="8" type="ORF">T05E11.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA92972.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T24520">
        <property type="entry name" value="T24520"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_502078.3">
        <property type="nucleotide sequence ID" value="NM_069677.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q22234"/>
    <dbReference type="GeneID" id="188130"/>
    <dbReference type="UCSC" id="T05E11.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011479"/>
    <dbReference type="CTD" id="188130"/>
    <dbReference type="WormBase" id="T05E11.2a">
        <property type="protein sequence ID" value="CE49841"/>
        <property type="gene ID" value="WBGene00011479"/>
        <property type="gene designation" value="clc-9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012777_0_0_1"/>
    <dbReference type="OrthoDB" id="5803795at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011479">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q22234">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF104">
        <property type="entry name" value="CLAUDIN-LIKE IN CAENORHABDITIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA92972.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="T05E11.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q22234"/>
        </source>
    </evidence>
    <sequence length="220" mass="24439" checksum="7002B176806CEF69" modified="2014-09-03" version="3">MASRGRICCIGFSSTFAIVSMILLAICMFSASFRYNLDNLGGVKDYGLFRFCYTPKSQPLSRDDDSNSKTCHLRNYINSAHCQEGGSHTQPSRDCFGDFELASIILISASLGCCILAICFAICTIFTSFGALAHSVVLIAAAMCSLSGFLTYTYYYELKDNQYELVSGYQFQIHYGWAYYVFGFSSLLQWAAFVCSLFGSAFVLVHKNKKRQSKVTSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q22290</accession>
    <name>Q22290_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T07C4.3</name>
        <name evidence="2 4" type="ORF">T07C4.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-329777">
            <id>Q22290</id>
        </interactant>
        <interactant intactId="EBI-316320">
            <id>O45904</id>
            <label>lec-1</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>5</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-329777">
            <id>Q22290</id>
        </interactant>
        <interactant intactId="EBI-312125">
            <id>Q8I4A4</id>
            <label>lec-3</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAA82576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S41016">
        <property type="entry name" value="S41016"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_499288.1">
        <property type="nucleotide sequence ID" value="NM_066887.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q22290"/>
    <dbReference type="DIP" id="DIP-25707N"/>
    <dbReference type="IntAct" id="Q22290">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="6239.T07C4.3a.1"/>
    <dbReference type="PaxDb" id="6239-T07C4.3a.1"/>
    <dbReference type="PeptideAtlas" id="Q22290"/>
    <dbReference type="GeneID" id="176451"/>
    <dbReference type="UCSC" id="T07C4.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011560"/>
    <dbReference type="CTD" id="176451"/>
    <dbReference type="WormBase" id="T07C4.3a">
        <property type="protein sequence ID" value="CE00602"/>
        <property type="gene ID" value="WBGene00011560"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R36B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422265_0_0_1"/>
    <dbReference type="InParanoid" id="Q22290"/>
    <dbReference type="OMA" id="DGSMMCR"/>
    <dbReference type="OrthoDB" id="5844168at2759"/>
    <dbReference type="PhylomeDB" id="Q22290"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011560">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q22290">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA82576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T07C4.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q22290"/>
        </source>
    </evidence>
    <sequence length="649" mass="71300" checksum="F17DEF7D069B9CDE" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2026-01-28" version="175" xmlns="https://uniprot.org/uniprot">
    <accession>Q22366-2</accession>
    <name>RIM_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Rab-3-interacting molecule unc-10</fullName>
            <shortName>Rim</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Uncoordinated protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">unc-10</name>
        <name evidence="1" type="ORF">T10A3.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nat. Neurosci." volume="4" first="997" last="1005">
            <title>A post-docking role for active zone protein Rim.</title>
            <authorList>
                <person name="Koushika S.P."/>
                <person name="Richmond J.E."/>
                <person name="Hadwiger G."/>
                <person name="Weimer R.M."/>
                <person name="Jorgensen E.M."/>
                <person name="Nonet M.L."/>
            </authorList>
            <dbReference type="PubMed" id="11559854"/>
            <dbReference type="DOI" id="10.1038/nn732"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2017" name="Anim. Cells Syst. (Seoul)" volume="21" first="185" last="189">
            <title>CFL-1, a novel F-box protein with leucine-rich repeat may interact with UNC-10 for the regulation of defecation and daumone response in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kim S.M."/>
                <person name="Hwang S.Y."/>
            </authorList>
            <dbReference type="PubMed" id="30460068"/>
            <dbReference type="DOI" id="10.1080/19768354.2017.1325779"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q22366-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q22366-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_009141 VSP_009140 VSP_009139"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024901.1">
        <property type="nucleotide sequence ID" value="NM_001029730.6"/>
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        <property type="protein sequence ID" value="CE31234"/>
        <property type="gene ID" value="WBGene00006750"/>
        <property type="gene designation" value="unc-10"/>
    </dbReference>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="T10A3.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T10A3.1b"/>
        </source>
    </evidence>
    <sequence length="1371" mass="154681" checksum="B6D7D918E58EFB71" modified="2002-06-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="201" xmlns="https://uniprot.org/uniprot">
    <accession>Q23587</accession>
    <accession>G4SPX0</accession>
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        <submittedName>
            <fullName evidence="11">EGF-like domain-containing protein</fullName>
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        <name evidence="11 13" type="primary">fbn-1</name>
        <name evidence="11" type="ORF">CELE_ZK783.1</name>
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    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD65255.1"/>
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        <property type="nucleotide sequence ID" value="NM_066269.6"/>
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        <property type="protein sequence ID" value="CE44082"/>
        <property type="gene ID" value="WBGene00022816"/>
        <property type="gene designation" value="fbn-1"/>
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    <dbReference type="Bgee" id="WBGene00022816">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="CDD" id="cd00054">
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        <property type="match status" value="17"/>
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        <property type="entry name" value="NELL2-like_EGF"/>
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        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="UROMODULIN-LIKE"/>
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        <property type="match status" value="4"/>
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        </location>
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    <feature type="chain" id="PRO_5004201582" evidence="8">
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        </location>
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    <feature type="domain" description="EGF-like" evidence="9">
        <location>
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            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
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        </location>
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    <feature type="domain" description="EGF-like" evidence="9">
        <location>
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        <location>
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        <location>
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            <end position="1646"/>
        </location>
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        <location>
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            <end position="1740"/>
        </location>
    </feature>
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        <location>
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            <end position="1878"/>
        </location>
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    <feature type="domain" description="EGF-like" evidence="9">
        <location>
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            <end position="1919"/>
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            <end position="2198"/>
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        <location>
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        <location>
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            <end position="2584"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1929"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="1094"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <end position="1111"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="1205"/>
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        <location>
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            <end position="1259"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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        </location>
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        <location>
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    </feature>
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    <feature type="disulfide bond" evidence="5">
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    <feature type="disulfide bond" evidence="5">
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="ZK783.1e"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="Q23587"/>
        </source>
    </evidence>
    <sequence length="2687" mass="282293" checksum="3BDADDDE6425EFA9" modified="2012-01-25" version="4"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-09-13" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q4A1S8</accession>
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            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
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            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
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        <name evidence="13" type="primary">bckd-1a</name>
        <name evidence="11" type="synonym">bckd-1A</name>
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        <name evidence="13" type="ORF">Y39E4A.3</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAJ21557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001033377.1">
        <property type="nucleotide sequence ID" value="NM_001038288.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4A1S8"/>
    <dbReference type="SMR" id="Q4A1S8"/>
    <dbReference type="IntAct" id="Q4A1S8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="176716"/>
    <dbReference type="UCSC" id="Y39E4A.3b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012713"/>
    <dbReference type="CTD" id="176716"/>
    <dbReference type="WormBase" id="Y39E4A.3b">
        <property type="protein sequence ID" value="CE38987"/>
        <property type="gene ID" value="WBGene00012713"/>
        <property type="gene designation" value="bckd-1A"/>
    </dbReference>
    <dbReference type="OMA" id="GMFRGVN"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="PhylomeDB" id="Q4A1S8"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012713">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q4A1S8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="90"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAJ21557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="Y39E4A.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q4A1S8"/>
        </source>
    </evidence>
    <sequence length="432" mass="49152" checksum="6671ADBF7F30B442" modified="2005-09-13" version="1">MMHRALLNASRRVATVRSMASTVEGDAFRLSEYSSKYLGHRKAAFTEKLEIVNADDTPALPIYRVTNAVGDVIDKSQDPNFDEQTSLKMYKTMTQLNIMDRILYDSQRQGRISFYMTSFGEEGNHVGSAAALEPQDLIYGQYREAGVLLWRGYTMENFMNQCYGNADDLGKGRQMPMHFGTKERNFVTISSPLTTQLPQAVGSAYAFKQQKDNNRIAVVYFGDGAASEGDAHAAFNFAATLKCPIIFFCRNNGYAISTPTSEQYGGDGIAGKGPAYGLHTIRVDGNDLLAVYNATKEARRVALTNRPVLIEAMTYRLGHHSTSDDSTAYRSSDEVQTWGDKDHPITRFKKYITERGWWNEEKEMEWQKEVKKRVLTEFAAAEKRKKAHYHDLFEDVYDELPLRLRRQRDELDAHVAEYKEHYPMLETLQSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-11-23" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ZEQ4</accession>
    <name>Q5ZEQ4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Copper transport protein 86</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y37H9A.1</name>
        <name evidence="1 3" type="ORF">Y37H9A.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAH60795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021753.1">
        <property type="nucleotide sequence ID" value="NM_001026582.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ZEQ4"/>
    <dbReference type="PeptideAtlas" id="Q5ZEQ4"/>
    <dbReference type="GeneID" id="173243"/>
    <dbReference type="UCSC" id="Y37H9A.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012576"/>
    <dbReference type="CTD" id="173243"/>
    <dbReference type="WormBase" id="Y37H9A.1b">
        <property type="protein sequence ID" value="CE37562"/>
        <property type="gene ID" value="WBGene00012576"/>
    </dbReference>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012576">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q5ZEQ4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH60795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y37H9A.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="Q5ZEQ4"/>
        </source>
    </evidence>
    <sequence length="498" mass="56751" checksum="C4DBE8DAA6EC73F5" modified="2004-11-23" version="1">MEKLLSELAELGARQKFNGEIDFGAEIASDSLLEVMKIVGSEELSQQVLEGFLEQAPTIHQVLLGMTFASYLQSTTSGEASPGAQELSEPLKKARRSIRLLLNLTQRSPDFASRISSESVELLETLLATGSFDVECLIILLKTSQATWLEFQKSPRYSALLQRVLSKYSPDFSENSTILAYFSVLFEMDYGFLSMCYAEMDAPTFCEILDVLRVILTRKTLKIHSNNLLFVLNLLELVVVDYEAFWRARERKEPQSVEQRRVATVEILNLEVEIVGEMCSNTEMTSYLNEKATAMNSVVDVLDAILHAEALFADFRAEQPSDWPKIESEHPRFEVLKRKIEEERRYEETQRRYPDRPRQPLPPKIQRVESSESLSLLANTIFSKYRSIDDVIGVPRVGELKLNCLKAIANLANLSDSNKLATLQNGRQGLISVLQCTTRRPEYFLESFTMRNQSIFCVRQLTDGCQENKEVVFNLQQPNQPIIDRKRLLEELGVHVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-11-23" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q60F71</accession>
    <name>Q60F71_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">clec-80</name>
        <name evidence="3" type="ORF">CELE_Y54G2A.39</name>
        <name evidence="5" type="ORF">Y54G2A.39</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD83527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023504.1">
        <property type="nucleotide sequence ID" value="NM_001028333.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q60F71"/>
    <dbReference type="SMR" id="Q60F71"/>
    <dbReference type="PaxDb" id="6239-Y54G2A.39"/>
    <dbReference type="PeptideAtlas" id="Q60F71"/>
    <dbReference type="GeneID" id="3565458"/>
    <dbReference type="KEGG" id="cel:CELE_Y54G2A.39"/>
    <dbReference type="UCSC" id="Y54G2A.39">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00043062"/>
    <dbReference type="CTD" id="3565458"/>
    <dbReference type="WormBase" id="Y54G2A.39a">
        <property type="protein sequence ID" value="CE37574"/>
        <property type="gene ID" value="WBGene00043062"/>
        <property type="gene designation" value="clec-80"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057197_1_0_1"/>
    <dbReference type="OMA" id="QDARNWC"/>
    <dbReference type="OrthoDB" id="5862733at2759"/>
    <dbReference type="PhylomeDB" id="Q60F71"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00043062">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q60F71">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23062:SF3">
        <property type="entry name" value="ANF_RECEPTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23062">
        <property type="entry name" value="HYPOTHETICAL PROTEIN C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004265766" evidence="1">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD83527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y54G2A.39a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q60F71"/>
        </source>
    </evidence>
    <sequence length="178" mass="20054" checksum="47454E86200D7E90" modified="2004-11-23" version="1">MKQFLLILLFFTSLAAAQQCWDSSDRLINGRCYKLVNQQLSYQDARSWCRYQNSVVSYLATVSDQITASFLASYAVTAFGSNEGSFWIGLSRSSSTYKWDDGTPLGWTNFNYQNSQDYVAESVTNAKWTAYNSETELKFVCSYYPLMPTTNLASSTDAPRTTEASTYWTSETLTSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2025-10-08" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6A576</accession>
    <name>Q6A576_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase M14 carboxypeptidase A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CELE_T06A4.3</name>
        <name evidence="14 16" type="ORF">T06A4.3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD73369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021612.1">
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    <keyword evidence="4" id="KW-0645">Protease</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
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        <location>
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            <end position="19"/>
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    <feature type="chain" id="PRO_5004271227" evidence="12">
        <location>
            <begin position="20"/>
            <end position="455"/>
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    <feature type="domain" description="Peptidase M14" evidence="13">
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            <end position="438"/>
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    <feature type="active site" description="Proton donor/acceptor" evidence="11">
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD73369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="T06A4.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="Q6A576"/>
        </source>
    </evidence>
    <sequence length="455" mass="52372" checksum="D40D8B58F3BFA307" modified="2004-09-13" version="1">MSYNTSLLIFLCFSAVSLSTQSFAVYRLLPKSQTDFQAIQRLYKNATDHDLNFWKTGKDKHGFWDVMVDMKNSKYFLDFLQVNDISYIKTIDDVEGLITKHENNKTLSNMFPRLWDDSSSAHYDFHTYGSYQRMTDWMKQLVVKYPKMVQYISIGKTTEGRNIDGVEIGGDSRTKKIFWIDGGIHAREWAAPHTALFFIHQLTSRANEPGIKKLLNEITFVVVPCLNPDGYEFTRSSTNPHVRLWRKNRSKMQCRKDIWGRNRCCRGVDLNRNFDFHFRESGTSDDPCSEIYQGPSPFSEPEAKAVRDALLSQRYKGRTDAYITLHTYSQIWIHPYGHKKDAYPGDIKDLYEVGKKAAQALKRVYGTKYVVGSGADTLYPASGGSEDWAKHEAKVKFVYLLELRPDEKNWDGFILDEKELIPTARETWEGVRVVAEAVLDRIVAGKSTAPRVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6A578</accession>
    <name>Q6A578_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">DUF4200 domain-containing protein</fullName>
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        <name evidence="2 4" type="ORF">C16A11.2</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD62419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367390.1">
        <property type="nucleotide sequence ID" value="NM_001381387.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6A578"/>
    <dbReference type="SMR" id="Q6A578"/>
    <dbReference type="PeptideAtlas" id="Q6A578"/>
    <dbReference type="GeneID" id="173758"/>
    <dbReference type="UCSC" id="C16A11.2a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00015815"/>
    <dbReference type="CTD" id="173758"/>
    <dbReference type="WormBase" id="C16A11.2b">
        <property type="protein sequence ID" value="CE36979"/>
        <property type="gene ID" value="WBGene00015815"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023953_0_0_1"/>
    <dbReference type="OrthoDB" id="16092at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015815">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6A578">
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    </dbReference>
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        <property type="entry name" value="CCDC93"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16441:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16441">
        <property type="entry name" value="FIDIPIDINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD62419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C16A11.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q6A578"/>
        </source>
    </evidence>
    <sequence length="431" mass="50665" checksum="BE35877CA9783C03" modified="2004-09-13" version="1">MHHEHRDEALKDFRHHLRRGVTTTRYMKRFDNSAMFNLSMDAKCTLAEYVVYSRTGDRLVGFTDETEETDNLKEASTKKHVPTTTVRKMMDEAVVETFKNDTESIKTSREGMCKEVDELNIPQRLEALESLVIDEAELFQQVKDTHKQLSDRYNTIKNRVVSNDQMFTFYNSNSDLDQLAEIVKFFEVTQARADELRACAECDVRMAQNHENLLRQNRDKNGKMQKYCVKQREIVDDWAERMKMVYVTCRDVVALQFRLDRYLKTLISHYRKRHMEKLLESSELTQEAKTNVIDHNVTIDILTFSAKIKGFMDEVEKSLVVEPASQEYRDAFVSYMNDVRTQLGEYHWKAKLTQDKTLAEKDTLAALRTRIRQKEREVSNTSDEMKRMLKIYESLKEVDSLLAQREEISPAFQYALDSREAEEEDEEAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JL32</accession>
    <name>Q7JL32_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sushi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cfh-1</name>
        <name evidence="8" type="ORF">CELE_F36H2.3</name>
        <name evidence="10" type="ORF">F36H2.3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB03077.4"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359596.1">
        <property type="nucleotide sequence ID" value="NM_001373341.1"/>
    </dbReference>
    <dbReference type="GeneID" id="185381"/>
    <dbReference type="UCSC" id="F36H2.3">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009500"/>
    <dbReference type="CTD" id="185381"/>
    <dbReference type="WormBase" id="F36H2.3a">
        <property type="protein sequence ID" value="CE42998"/>
        <property type="gene ID" value="WBGene00009500"/>
        <property type="gene designation" value="cfh-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6480633at2759"/>
    <dbReference type="PhylomeDB" id="Q7JL32"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009500">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JL32">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051503">
        <property type="entry name" value="ComplSys_Reg/VirEntry_Med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785:SF2">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004287657" evidence="6">
        <location>
            <begin position="21"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="191"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="275"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="346"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="421"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="492"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="630"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="701"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="771"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="842"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="912"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="983"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="1255"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="1328"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="494"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1360"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB03077.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F36H2.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q7JL32"/>
        </source>
    </evidence>
    <sequence length="1390" mass="142158" checksum="ABC554D2BE30C6A1" modified="2008-11-04" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JL36</accession>
    <name>Q7JL36_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tbc-3</name>
        <name evidence="5" type="ORF">CELE_F32B6.8</name>
        <name evidence="7" type="ORF">F32B6.8</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAE46669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023164.1">
        <property type="nucleotide sequence ID" value="NM_001027993.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JL36"/>
    <dbReference type="SMR" id="Q7JL36"/>
    <dbReference type="PeptideAtlas" id="Q7JL36"/>
    <dbReference type="GeneID" id="177845"/>
    <dbReference type="KEGG" id="cel:CELE_F32B6.8"/>
    <dbReference type="UCSC" id="F32B6.8a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009322"/>
    <dbReference type="CTD" id="177845"/>
    <dbReference type="WormBase" id="F32B6.8a">
        <property type="protein sequence ID" value="CE35519"/>
        <property type="gene ID" value="WBGene00009322"/>
        <property type="gene designation" value="tbc-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018687_5_1_1"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009322">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JL36">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000004">
        <property type="entry name" value="TBC1 domain family, member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="173"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAE46669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F32B6.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q7JL36"/>
        </source>
    </evidence>
    <sequence length="475" mass="54449" checksum="1C1A307C8C03AA38" modified="2004-07-05" version="1">MLLCTNLCFKRLDQFSAGKIGHEINNNDVSDAWDTRVKVDETLASASAAKVLAAHAAGKTHRDEEIMPPVSAAPTKNSRQQALQRLAIQKEPLPSSVSSTPQTANPIYPKLPEISDQPRSAVPMASAPPHGGDRDQTRFARLRRLFSNGKSSGKNSPPVDVDLEKLREDCWMGIPHKLRPQAWRLLSGYLPTNAERREVTLQCKRDEYWHYVEQYFHSRFDDQNADTFRQINIDIPRMCPLIPLFQQKMVQEMFERILYIWAIRHPASGYVQGINDLVTPFFVVFLSEFIPQDVEVGSFDVSQLPLEQCQLIEADSFWCVSSLLDSIQDNYTFAQPGIQRKVLQLRHLMSRVDRPLHKHLESNGIEYLQFAFRWMNNLLMREIPLRATIRLWDTYLSEPDGFMQFHNYVCAAFLRTWSKQLQAEKDFQGVMILLQNLPTQSWGDREICELTADAFSLQSVFDGARRHLSAQAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JL61</accession>
    <name>Q7JL61_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UNC-76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">unc-76</name>
        <name evidence="7" type="ORF">C01G10.11</name>
        <name evidence="5" type="ORF">CELE_C01G10.11</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zygin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAC70075.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741641.2">
        <property type="nucleotide sequence ID" value="NM_171553.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JL61"/>
    <dbReference type="SMR" id="Q7JL61"/>
    <dbReference type="GeneID" id="180014"/>
    <dbReference type="UCSC" id="C01G10.11a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006808"/>
    <dbReference type="CTD" id="31179"/>
    <dbReference type="WormBase" id="C01G10.11b">
        <property type="protein sequence ID" value="CE39211"/>
        <property type="gene ID" value="WBGene00006808"/>
        <property type="gene designation" value="unc-76"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7959977at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006808">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JL61">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099641">
        <property type="term" value="P:anterograde axonal protein transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="SynGO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007413">
        <property type="term" value="P:axonal fasciculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030516">
        <property type="term" value="P:regulation of axon extension"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050807">
        <property type="term" value="P:regulation of synapse organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011680">
        <property type="entry name" value="FEZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394:SF12">
        <property type="entry name" value="LD08195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394">
        <property type="entry name" value="ZYGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07763">
        <property type="entry name" value="FEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC70075.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C01G10.11b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q7JL61"/>
        </source>
    </evidence>
    <sequence length="369" mass="41587" checksum="BF29AC6D8FD0823A" modified="2005-12-20" version="1">MEAADLRVPDIPLASCDDDDIDSNKNLSNHSSDEKHHCNSNSDEERLHDEFSGSLEDLVGNFDEKIAACLKDHEVTTADIAPVQIRTQEEVMNESQTWWTLTGNFGNIQPLDFGTSSICKKMAAALDSDSLKDDASTRRSMTNSDDEDLLRQQMDVHQMIGHHHGSTDTGGETPPQTADQVIEEIDEMLQSCDFTGSMMTDRTMESVDSMYSSMRSPFPSSIQSSDADIKLRSAQALVSNPDNLQELSYSKLVTLCAEMEQLIRVYNESLVDELAHRDELDYEKEMKNSFISLLLAIQNKRRVYANDRKRKVGKASDASQLPQYLTATIPYNDHQHIDNASIASLIKSEKMKRDINKYLIDKEYQLCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JL62</accession>
    <name>Q7JL62_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UNC-76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">unc-76</name>
        <name evidence="7" type="ORF">C01G10.11</name>
        <name evidence="5" type="ORF">CELE_C01G10.11</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zygin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAB02712.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T18821">
        <property type="entry name" value="T18821"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_506712.4">
        <property type="nucleotide sequence ID" value="NM_074311.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7JL62"/>
    <dbReference type="SMR" id="Q7JL62"/>
    <dbReference type="IntAct" id="Q7JL62">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="180014"/>
    <dbReference type="UCSC" id="C01G10.11a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006808"/>
    <dbReference type="CTD" id="31179"/>
    <dbReference type="WormBase" id="C01G10.11a">
        <property type="protein sequence ID" value="CE39210"/>
        <property type="gene ID" value="WBGene00006808"/>
        <property type="gene designation" value="unc-76"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041596_2_0_1"/>
    <dbReference type="OrthoDB" id="7959977at2759"/>
    <dbReference type="PhylomeDB" id="Q7JL62"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006808">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7JL62">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099641">
        <property type="term" value="P:anterograde axonal protein transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="SynGO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007413">
        <property type="term" value="P:axonal fasciculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030516">
        <property type="term" value="P:regulation of axon extension"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050807">
        <property type="term" value="P:regulation of synapse organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011680">
        <property type="entry name" value="FEZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394:SF12">
        <property type="entry name" value="LD08195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394">
        <property type="entry name" value="ZYGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07763">
        <property type="entry name" value="FEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB02712.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C01G10.11a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q7JL62"/>
        </source>
    </evidence>
    <sequence length="378" mass="42336" checksum="4BBC004A395800EB" modified="2005-12-20" version="1">MEAADLRVPDIPLASCDDDDIDSNKNLSNHSSDEKHHCNSNSDEERLHDEFSGSLEDLVGNFDEKIAACLKDHEVTTADIAPVQIRTQEEVMNESQTWWTLTGNFGNIQPLDFGTSSICKKMAAALDSDSLKDDASTRRSMTNSDDEDLLRQQMDVHQMIGHHHGSTDTGGETPPQTADQVIEEIDEMLQSCDFTGSMMTDRTMESVDSMYSSMRSPFPSSIQSSDADIKLRSAQALVSNPDNLQELSYSKLVTLCAEMEQLIRVYNESLVDELAHRDELDYEKEMKNSFISLLLAIQNKRRVYANDRKRKVGKASDASQLPQYLTATIPYNDHQHIDNASIASLIKILRAIHDDNTTVPTLLTDYILTHVCPKNISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q7YXB6</accession>
    <name>Q7YXB6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_M01F1.8</name>
        <name evidence="1 3" type="ORF">M01F1.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAD92393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022689.1">
        <property type="nucleotide sequence ID" value="NM_001027518.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7YXB6"/>
    <dbReference type="PeptideAtlas" id="Q7YXB6"/>
    <dbReference type="GeneID" id="175454"/>
    <dbReference type="UCSC" id="M01F1.8b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00010814"/>
    <dbReference type="CTD" id="175454"/>
    <dbReference type="WormBase" id="M01F1.8b">
        <property type="protein sequence ID" value="CE34206"/>
        <property type="gene ID" value="WBGene00010814"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163562_0_0_1"/>
    <dbReference type="OrthoDB" id="5791987at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010814">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7YXB6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD92393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="M01F1.8b"/>
        </source>
    </evidence>
    <sequence length="124" mass="14006" checksum="89959511FC609B12" modified="2003-10-01" version="1">MATILHKQGSVVAVSHDMMMVRYDGKGVLFKKELLTRGYKHDDIVQFNARKATTVDIEVGDKLSQMANYELAWVGTELKFIKQGRMLVAEGAVINIPDDKAQYMFVDWKYTKNPPTLAKAILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q7YXC4</accession>
    <name>Q7YXC4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">pha-1</name>
        <name evidence="1" type="ORF">CELE_Y48A6C.5</name>
        <name evidence="3" type="ORF">Y48A6C.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAD91711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022891.1">
        <property type="nucleotide sequence ID" value="NM_001027720.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7YXC4"/>
    <dbReference type="GeneID" id="176543"/>
    <dbReference type="AGR" id="WB:WBGene00004010"/>
    <dbReference type="CTD" id="176543"/>
    <dbReference type="WormBase" id="Y48A6C.5b">
        <property type="protein sequence ID" value="CE34124"/>
        <property type="gene ID" value="WBGene00004010"/>
        <property type="gene designation" value="pha-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5902596at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004010">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7YXC4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048557">
        <property type="term" value="P:embryonic digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009497">
        <property type="entry name" value="Regulator_protein_PHA-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06542">
        <property type="entry name" value="PHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD91711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y48A6C.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="Q7YXC4"/>
        </source>
    </evidence>
    <sequence length="453" mass="53053" checksum="CE799DEAFFFADA70" modified="2003-10-01" version="1">MNTPNSSCTILFENLYDNDLALKLFNNRTIVDNILRNVKGDINNRLELRLVNKSFNLAAIHVIRKENRTVVFHKFNRCDRLHKISPCPDCSVHLNSVKLNKKNIFQYARFLKQTMKIMVIKIRIEDSKRVCCMITDVHQVIHKSLIGSDYDKVEEFVGIDQISFSTCIPCEKIAANCKVFGPVQNDMFNAILRLKHHYDVLQVKDMRLYKLMILNKEDPTVVEDFINSNITCSKLTIFLMYMYEKEAFGYSLPREFLDLLIKKWNVKTVEIVPRQDQPIPYYFHCNTDFIVPKAKFYVDYWTQPRSKYTLDGVEIDLQLTKVVEQQIKNRKSLFDNFIANARRIFPSNKITVRFSKEVCQEMMSQGNVEDFISGIILMTQKDAQPNSHISLKLYPEEVDAPLIDSFLRENFEKKFDSWNLETVSDSSANLPAEKCYQFFNQSTNCKIIFYICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2025-10-08" version="165" xmlns="https://uniprot.org/uniprot">
    <accession>Q7YXC6</accession>
    <name>Q7YXC6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear Hormone Receptor family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nhr-95</name>
        <name evidence="13" type="ORF">CELE_Y39B6A.17</name>
        <name evidence="15" type="ORF">Y39B6A.17</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAD91709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001024230.1">
        <property type="nucleotide sequence ID" value="NM_001029059.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7YXC6"/>
    <dbReference type="SMR" id="Q7YXC6"/>
    <dbReference type="GeneID" id="180254"/>
    <dbReference type="UCSC" id="Y39B6A.17a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003685"/>
    <dbReference type="CTD" id="180254"/>
    <dbReference type="WormBase" id="Y39B6A.17b">
        <property type="protein sequence ID" value="CE34507"/>
        <property type="gene ID" value="WBGene00003685"/>
        <property type="gene designation" value="nhr-95"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007368_7_1_1"/>
    <dbReference type="OrthoDB" id="5816380at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003685">
        <property type="expression patterns" value="Expressed in anatomical system and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7YXC6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051152">
        <property type="entry name" value="C.elegans_Orphan_NR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680:SF13">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="124"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAD91709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="Y39B6A.17b"/>
        </source>
    </evidence>
    <sequence length="399" mass="46266" checksum="3044D16D789A33FD" modified="2003-10-01" version="1">MKIAKISHILPQKCEICKIQKCHGNHFGVNSCRACAAFFRRTVNSKWSRMRCLGGSCNQISFLCKPCRLQQCFNGGMMTNNFQYNRDVICPMDPQPTVSIPKSLEIYLGKPYFVMLSEKNSEKTEIDLHRLLGEASKILSQGSASPSFCAGNQLKKLSLGLPNQIIAPRFKMAEKVAKAELVANWEYYVKKVAAWLAHFDDFRRLDVDLQMKLLQSIWHIWSRLEKLSATAKYRKTAQSYKKTDVVLQGDIVVDVEHVYMDTRWLSNFPLEQFRRFMIHSSCDQYDVTQALYDLSPTDIELTYMLAQLCFQYAGNRYQGRILEVCDRFLTVLSNDLHDYYIKDLGMLRYAGRLAKMMQVNNSIQENIRKGRERMQLIRCFGVLKLEFSHPEMFLDSGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2025-10-08" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q7YXD9</accession>
    <name>Q7YXD9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ccch-1</name>
        <name evidence="8" type="ORF">CELE_F38B7.1</name>
        <name evidence="10" type="ORF">F38B7.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA98476.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21955">
        <property type="entry name" value="T21955"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_505927.2">
        <property type="nucleotide sequence ID" value="NM_073526.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7YXD9"/>
    <dbReference type="PeptideAtlas" id="Q7YXD9"/>
    <dbReference type="GeneID" id="179584"/>
    <dbReference type="UCSC" id="F38B7.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009532"/>
    <dbReference type="CTD" id="179584"/>
    <dbReference type="WormBase" id="F38B7.1b">
        <property type="protein sequence ID" value="CE31934"/>
        <property type="gene ID" value="WBGene00009532"/>
        <property type="gene designation" value="ccch-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009532">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q7YXD9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF185">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA98476.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F38B7.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q7YXD9"/>
        </source>
    </evidence>
    <sequence length="419" mass="45036" checksum="1E37F78B2DB0A6BC" modified="2003-10-01" version="1">MSIENYHLSFLKSLCSADNGVGVPSHSINGFGSTPSTQSSPTSAPNTIESLLEPFGLQNSQADFAAALAQLTGQSVKQMDRQQASAIQRPTSFAGSSLFGASEFGNPLGAPGTPIGSQHQMSIGQNLVSASSPYSTPQLTPMATPNGQAPPPKNPKLYKTELCRSWMDHGRCNYGERCQYAHGELEKRPVPRHPKYKTEACQSFHQSGYCPYGPRCHFIHNEPPSAQSQYSTPISTPVPHQTTPSLYASQYHNVTMKQQQPTQNASNVPNNVLQRVYSLPNGGYGSAGESPPCSSNDSGSESPNGSFSPGLDLEDSGPFSAGFLSASPHKLQQQKTNAAPRVPTSRFLSYDQSNLNDSQFSNLLNDICQWNIEDSLSTPFSGFLPSKWSTTTEETSPATTTPVSTPGRLPVFAQLSNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MNR7</accession>
    <name>Q8MNR7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuropeptide-Like Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nssp-53</name>
        <name evidence="2" type="ORF">CELE_F27B10.1</name>
        <name evidence="4" type="ORF">F27B10.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD70072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741563.1">
        <property type="nucleotide sequence ID" value="NM_171480.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MNR7"/>
    <dbReference type="PaxDb" id="6239-F27B10.1"/>
    <dbReference type="GeneID" id="259627"/>
    <dbReference type="UCSC" id="F27B10.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017850"/>
    <dbReference type="CTD" id="259627"/>
    <dbReference type="WormBase" id="F27B10.1a">
        <property type="protein sequence ID" value="CE30769"/>
        <property type="gene ID" value="WBGene00017850"/>
        <property type="gene designation" value="nssp-53"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TIIH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2796215_0_0_1"/>
    <dbReference type="OMA" id="EVHPSIN"/>
    <dbReference type="OrthoDB" id="5837210at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017850">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MNR7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004312570" evidence="1">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD70072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F27B10.1a"/>
        </source>
    </evidence>
    <sequence length="68" mass="7815" checksum="83B96D0D9B2C7329" modified="2002-10-01" version="1">MVRSIVLLLLLVALVSATYSRFGSNKANKPEEAHPSINDQIMQGSHIRYYGRFRDGSDDVLNRYFNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MNS6</accession>
    <name>Q8MNS6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">alh-11</name>
        <name evidence="6" type="ORF">CELE_F42G9.5</name>
        <name evidence="8" type="ORF">F42G9.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379575.1">
        <property type="nucleotide sequence ID" value="NM_001393265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MNS6"/>
    <dbReference type="SMR" id="Q8MNS6"/>
    <dbReference type="PeptideAtlas" id="Q8MNS6"/>
    <dbReference type="GeneID" id="185679"/>
    <dbReference type="UCSC" id="F42G9.5a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000117"/>
    <dbReference type="CTD" id="185679"/>
    <dbReference type="WormBase" id="F42G9.5b">
        <property type="protein sequence ID" value="CE30790"/>
        <property type="gene ID" value="WBGene00000117"/>
        <property type="gene designation" value="alh-11"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000117">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MNS6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07090">
        <property type="entry name" value="ALDH_F9_TMBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD61887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F42G9.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MNS6"/>
        </source>
    </evidence>
    <sequence length="503" mass="54743" checksum="16E6ECE8A559E4B2" modified="2002-10-01" version="1">MRIFPNLINLNSLTETKLLELSSHFVAGNHVEFPSDRKFEVIEPRSGKPMATWHYATRDQVDLTVKEAKKAQKQWAKSSWMERSEILKKTGDLLKTHCNDIAYWECISNGKPIAEAKADVLSCVDTFYFYSGIASDLLGQHVPLDASRYAYTRRLPVGVVAAIGAWNYPIQTCSWKTAPALACGNAVIYKPSPLSPVTALILAEILKSAGLPDGVFNVIQGDAETAQDLIHHDGVSKVSFTGSIPTGKKIMKACADRNIKPVTLELGGKSALIVFDDADIDSAVSCAMMANFYSQGQVCSNASKVLVHKSVLKEFTKKLVDHTQKMKIGDPLKEDTQVGSHISAEHRNKVEGYISTAIAEGATKLCGGDRVAVHGLENGFYLSPCILTGITPKMTVYREEIFGSVLLIIPFDTEDEAIKIANDTDMGLAAGLVTKDLSRSYRVSEQLNAGNVYVNTYNDVSPLVPFGGVGESGFGRENGTAVLEHYTHLKSVFVNTGTCPNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MNS7</accession>
    <name>Q8MNS7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exosome complex component RRP45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">exos-9</name>
        <name evidence="1" type="ORF">CELE_F37C12.13</name>
        <name evidence="3" type="ORF">F37C12.13</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD70742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379934.1">
        <property type="nucleotide sequence ID" value="NM_001392139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MNS7"/>
    <dbReference type="SMR" id="Q8MNS7"/>
    <dbReference type="PeptideAtlas" id="Q8MNS7"/>
    <dbReference type="GeneID" id="176012"/>
    <dbReference type="KEGG" id="cel:CELE_F37C12.13"/>
    <dbReference type="UCSC" id="F37C12.13a.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018154"/>
    <dbReference type="CTD" id="176012"/>
    <dbReference type="WormBase" id="F37C12.13b">
        <property type="protein sequence ID" value="CE30780"/>
        <property type="gene ID" value="WBGene00018154"/>
        <property type="gene designation" value="exos-9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3052274_0_0_1"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018154">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MNS7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD70742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F37C12.13b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MNS7"/>
        </source>
    </evidence>
    <sequence length="65" mass="7248" checksum="64EEA596DC7AEE9D" modified="2002-10-01" version="1">MRVQPVTNCEKAVILEALKIGKRFDFRSLEEFRDVKLVVGAEVGTAICTIGNTKFSNGCSKCRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MNT7</accession>
    <name>Q8MNT7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxyisobutyryl-CoA hydrolase, mitochondrial</fullName>
            <ecNumber evidence="5">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">hach-1</name>
        <name evidence="13" type="ORF">CELE_F09F7.4</name>
        <name evidence="15" type="ORF">F09F7.4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="5"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD68385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741144.1">
        <property type="nucleotide sequence ID" value="NM_171127.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MNT7"/>
    <dbReference type="SMR" id="Q8MNT7"/>
    <dbReference type="GeneID" id="175766"/>
    <dbReference type="UCSC" id="F09F7.4a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017301"/>
    <dbReference type="CTD" id="175766"/>
    <dbReference type="WormBase" id="F09F7.4b">
        <property type="protein sequence ID" value="CE30654"/>
        <property type="gene ID" value="WBGene00017301"/>
        <property type="gene designation" value="hach-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_22_1_1"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017301">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MNT7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD68385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F09F7.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MNT7"/>
        </source>
    </evidence>
    <sequence length="363" mass="40142" checksum="C81843837FBAF2A9" modified="2002-10-01" version="1">MSFSVSAAAKSEILVDTHGSKKVVTLNRPKALNALNLEMVREFYPKLQAWNSSSDVDLVILKGSGDKAFCAGGDVLAVVRSFKDSESGKECTMHKDFFREEYILNHLIGTLNKQYVCLIDGIVMGGGCGLSVNGRFRVATEKTMLAMPETALGLFPDVGGSYFLSRLKGNLGMYLALTGYRLLGADAFHAGLATHFVESSELAKLEKELVNIKDVTENSVDEVIRSFEPKKIPEFSLSKNLAQIRDSFKAKSVEEILASLEKDGSDWAKKQAATLGKMSPTSLKVTHRQITEGSKMSYAKIFTMEYRLTQRFLADKDFHEGCRAILVDKDRKPKWNPATLADVKDSVVDNYFSPLPNNSDLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MNV2</accession>
    <name>Q8MNV2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C18F10.7</name>
        <name evidence="2" type="ORF">CELE_C18F10.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD65205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741185.1">
        <property type="nucleotide sequence ID" value="NM_171160.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MNV2"/>
    <dbReference type="SMR" id="Q8MNV2"/>
    <dbReference type="GeneID" id="175889"/>
    <dbReference type="UCSC" id="C18F10.7a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00015978"/>
    <dbReference type="CTD" id="175889"/>
    <dbReference type="WormBase" id="C18F10.7b">
        <property type="protein sequence ID" value="CE30608"/>
        <property type="gene ID" value="WBGene00015978"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1911427_0_0_1"/>
    <dbReference type="OrthoDB" id="1585644at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015978">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MNV2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF31">
        <property type="entry name" value="LD31969P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C18F10.7b"/>
        </source>
    </evidence>
    <sequence length="136" mass="15629" checksum="DEDF1A77CF3D4A27" modified="2002-10-01" version="1">MPLDSPAKLEFPLHWAVYVDCKDELNELLKNKSTLEIDKIDPRGRTPLMLAVTLQHFDCARLLMDAGADASIPNKEMWSVSNEAVAQGNEQFIQEVIHHRDYQRANRGAHAMKRSLEKLAEVPDFFCEMNWDFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MNV5</accession>
    <name>Q8MNV5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C18C4.7</name>
        <name evidence="3" type="ORF">CELE_C18C4.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD65107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359878.1">
        <property type="nucleotide sequence ID" value="NM_001373024.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MNV5"/>
    <dbReference type="SMR" id="Q8MNV5"/>
    <dbReference type="GeneID" id="178941"/>
    <dbReference type="UCSC" id="C18C4.5b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00015968"/>
    <dbReference type="CTD" id="178941"/>
    <dbReference type="WormBase" id="C18C4.7e">
        <property type="protein sequence ID" value="CE30729"/>
        <property type="gene ID" value="WBGene00015968"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011277_0_0_1"/>
    <dbReference type="OrthoDB" id="5832686at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015968">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MNV5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="911"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD65107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C18C4.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MNV5"/>
        </source>
    </evidence>
    <sequence length="1022" mass="118466" checksum="939520B2D5EA107B" modified="2002-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MNV9</accession>
    <name>Q8MNV9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">sup-37</name>
        <name evidence="5" type="ORF">C01B7.1</name>
        <name evidence="3" type="ORF">CELE_C01B7.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD62083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370344.1">
        <property type="nucleotide sequence ID" value="NM_001383359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MNV9"/>
    <dbReference type="SMR" id="Q8MNV9"/>
    <dbReference type="PeptideAtlas" id="Q8MNV9"/>
    <dbReference type="GeneID" id="179257"/>
    <dbReference type="UCSC" id="C01B7.1a.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006342"/>
    <dbReference type="CTD" id="179257"/>
    <dbReference type="WormBase" id="C01B7.1b">
        <property type="protein sequence ID" value="CE30719"/>
        <property type="gene ID" value="WBGene00006342"/>
        <property type="gene designation" value="sup-37"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495436_0_0_1"/>
    <dbReference type="OrthoDB" id="5844122at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006342">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MNV9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048557">
        <property type="term" value="P:embryonic digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD62083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C01B7.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q8MNV9"/>
        </source>
    </evidence>
    <sequence length="550" mass="59867" checksum="D2FE2C614ECCEB7B" modified="2002-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MNW1</accession>
    <name>Q8MNW1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rbm-5</name>
        <name evidence="2" type="ORF">CELE_T08B2.5</name>
        <name evidence="4" type="ORF">T08B2.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD67606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T28753">
        <property type="entry name" value="T28753"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379814.1">
        <property type="nucleotide sequence ID" value="NM_001392416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MNW1"/>
    <dbReference type="SMR" id="Q8MNW1"/>
    <dbReference type="GeneID" id="172312"/>
    <dbReference type="UCSC" id="T08B2.5c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020346"/>
    <dbReference type="CTD" id="172312"/>
    <dbReference type="WormBase" id="T08B2.5d">
        <property type="protein sequence ID" value="CE13429"/>
        <property type="gene ID" value="WBGene00020346"/>
        <property type="gene designation" value="rbm-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020346">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MNW1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD67606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T08B2.5d"/>
        </source>
    </evidence>
    <sequence length="163" mass="19094" checksum="E127E7F4B0BE8166" modified="2002-10-01" version="1">MLPFVFNADDDGKRVQNEEGNYDPTDHQRQMEDYYKQYEEQRVANSFHNTTGRPDLVAMQARLAETEQAIHRLNEEKKQPPPGFPIMTTPATQPEISIPRSGENKSSRSPSWAREARRSRSRSRDRRGGRSRSRSPSRRRTSRDRRDDRSSRRRRGPIINQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2025-10-08" version="167" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MNW2</accession>
    <name>Q8MNW2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear Hormone Receptor family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">nhr-117</name>
        <name evidence="14" type="ORF">CELE_F16B4.12</name>
        <name evidence="16" type="ORF">F16B4.12</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD69577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E88954">
        <property type="entry name" value="E88954"/>
    </dbReference>
    <dbReference type="PIR" id="T32674">
        <property type="entry name" value="T32674"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294718.1">
        <property type="nucleotide sequence ID" value="NM_001307789.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MNW2"/>
    <dbReference type="GeneID" id="24104436"/>
    <dbReference type="KEGG" id="cel:CELE_F16B4.12"/>
    <dbReference type="UCSC" id="F16B4.12a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003707"/>
    <dbReference type="CTD" id="24104436"/>
    <dbReference type="WormBase" id="F16B4.12a">
        <property type="protein sequence ID" value="CE24906"/>
        <property type="gene ID" value="WBGene00003707"/>
        <property type="gene designation" value="nhr-117"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007368_7_1_1"/>
    <dbReference type="OrthoDB" id="5788487at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003707">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MNW2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051152">
        <property type="entry name" value="C.elegans_Orphan_NR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680:SF33">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="191"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD69577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="F16B4.12a"/>
        </source>
    </evidence>
    <sequence length="435" mass="50794" checksum="2346129E23EAB918" modified="2002-10-01" version="1">MQNSIDFCSASSSTSSNYSSPPAVLDIDQVLEKCQICYQPGHGYHFGAFICRACAAFFRRCHFSLALDQRKCRLLSGSCQPNKNGRWFCKKCRFDKCLELGMTTTNIQYDRDAFKSSASFLKNKSVAKRVADRVSVPMTVESALGINPIMIFTYADENKQFPFIDISQLVDKALSSILTPISVRKIKKMSNLEQLTQGLDEFQWTQKESVSQIVRLSANDHLNDFQTYMCAAAKWLSYSDRIRNLDDELKIQILQCIWFNWGRLERIATTAKMRNKRKCGKKQFVFSNNILLDYDEMSSDLSFWSNYTFEEMKYFFIPTEMFYDEVICEMEEVQPDNMETTFIISLMCFHLTGKQFGGQVQEEMDQLQDLLSDELHEYYLKKNMTMYSLRLKQLMKIKEKFLKLRYKRCEKYKIAGIFEAFHTNLSNPEFFMIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MNX2</accession>
    <name>Q8MNX2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein containing ALS2cr12 (ALS2CR12) signature</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">pals-23</name>
        <name evidence="3" type="ORF">C29F9.3</name>
        <name evidence="1" type="ORF">CELE_C29F9.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD66062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379740.1">
        <property type="nucleotide sequence ID" value="NM_001393245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MNX2"/>
    <dbReference type="SMR" id="Q8MNX2"/>
    <dbReference type="GeneID" id="3565025"/>
    <dbReference type="UCSC" id="C29F9.3b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016218"/>
    <dbReference type="CTD" id="3565025"/>
    <dbReference type="WormBase" id="C29F9.3b">
        <property type="protein sequence ID" value="CE30623"/>
        <property type="gene ID" value="WBGene00016218"/>
        <property type="gene designation" value="pals-23"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2560368_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016218">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8MNX2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007007"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD66062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C29F9.3b"/>
        </source>
    </evidence>
    <sequence length="82" mass="9474" checksum="CAEF2A72E70D3235" modified="2002-10-01" version="1">MSHELLFSKVKLKINQFIDDLKSTDSLFSGMKFASMLMLIRYRTAELLSRSLSLISWKKRTKTPANSSRRKGLVDSLTMEVF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-11-11" modified="2026-01-28" version="163" xmlns="https://uniprot.org/uniprot">
    <accession>Q95Y80-2</accession>
    <name>BET1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Bromodomain-containing protein bet-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bet-1</name>
        <name evidence="3" type="ORF">Y119C1B.8</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2010" name="Development" volume="137" first="1045" last="1053">
            <title>Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans.</title>
            <authorList>
                <person name="Shibata Y."/>
                <person name="Takeshita H."/>
                <person name="Sasakawa N."/>
                <person name="Sawa H."/>
            </authorList>
            <dbReference type="PubMed" id="20181741"/>
            <dbReference type="DOI" id="10.1242/dev.042812"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HISTONE H4</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF VAL-113 AND GLU-585</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Biol. Open" volume="2" first="1354" last="1363">
            <title>Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation.</title>
            <authorList>
                <person name="Fisher K."/>
                <person name="Gee F."/>
                <person name="Wang S."/>
                <person name="Xue F."/>
                <person name="Knapp S."/>
                <person name="Philpott M."/>
                <person name="Wells C."/>
                <person name="Rodriguez M."/>
                <person name="Snoek L.B."/>
                <person name="Kammenga J."/>
                <person name="Poulin G.B."/>
            </authorList>
            <dbReference type="PubMed" id="24285704"/>
            <dbReference type="DOI" id="10.1242/bio.20136007"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E83659" last="E83659">
            <title>An RNAi-based dimorphic genetic screen identified the double bromodomain protein BET-1 as a sumo-dependent attenuator of RAS-mediated signalling.</title>
            <authorList>
                <person name="Gee F."/>
                <person name="Fisher K."/>
                <person name="Klemstein U."/>
                <person name="Poulin G.B."/>
            </authorList>
            <dbReference type="PubMed" id="24349540"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0083659"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SMO-1 AND UBC-9</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUMOYLATION AT LYS-252</scope>
        <scope>MUTAGENESIS OF LYS-252; LYS-253; LYS-264; 276-LYS-LYS-277; LYS-304; LYS-313 AND LYS-315</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2014" name="Development" volume="141" first="209" last="218">
            <title>HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans.</title>
            <authorList>
                <person name="Shibata Y."/>
                <person name="Sawa H."/>
                <person name="Nishiwaki K."/>
            </authorList>
            <dbReference type="PubMed" id="24346701"/>
            <dbReference type="DOI" id="10.1242/dev.090746"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2021" name="Proc. Natl. Acad. Sci. U.S.A." volume="118" first="0" last="0">
            <title>The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity.</title>
            <authorList>
                <person name="Snoznik C."/>
                <person name="Medvedeva V."/>
                <person name="Mojsilovic-Petrovic J."/>
                <person name="Rudich P."/>
                <person name="Oosten J."/>
                <person name="Kalb R.G."/>
                <person name="Lamitina T."/>
            </authorList>
            <dbReference type="PubMed" id="34593637"/>
            <dbReference type="DOI" id="10.1073/pnas.2104664118"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q95Y80-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q95Y80-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_057965 VSP_057964"/>
        </isoform>
    </comment>
    <dbReference type="WormBase" id="Y119C1B.8b">
        <property type="protein sequence ID" value="CE33207"/>
        <property type="gene ID" value="WBGene00022473"/>
        <property type="gene designation" value="bet-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y119C1B.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y119C1B.8b"/>
        </source>
    </evidence>
    <sequence length="765" mass="84900" checksum="3C0724E9B6F53E79" modified="2012-01-25" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q966A0-2</accession>
    <name>SVH11_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Putative galactoside 2-alpha-L-fucosyltransferase svh-11</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Suppressor of vhp-1 deletion lethality protein svh-11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">svh-11</name>
        <name evidence="5" type="ORF">Y5H2B.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2019" name="Genetics" volume="213" first="491" last="500">
            <title>N-Glycosylation of the Discoidin Domain Receptor Is Required for Axon Regeneration in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shimizu T."/>
                <person name="Kato Y."/>
                <person name="Sakai Y."/>
                <person name="Hisamoto N."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="31371405"/>
            <dbReference type="DOI" id="10.1534/genetics.119.302492"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q966A0-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q966A0-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_060577"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="RefSeq" id="NP_001303775.1">
        <property type="nucleotide sequence ID" value="NM_001316846.1"/>
    </dbReference>
    <dbReference type="WormBase" id="Y5H2B.1b">
        <property type="protein sequence ID" value="CE51117"/>
        <property type="gene ID" value="WBGene00021164"/>
        <property type="gene designation" value="svh-11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="31371405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="31371405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y5H2B.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y5H2B.1b"/>
        </source>
    </evidence>
    <sequence length="356" mass="41571" checksum="92CE18917FCBBE69" modified="2001-12-01" version="1">MRLFHFLKFLTINNFSRYCLKIVKVHIIWITIICIIYFNWRFKKLDFMAIPYPPAVIKFNTSAKYLSSNLASSSQLGNNIFEIASLYGLSKHLNRTPLFFIENGYHKKMLDNLRKTMPRLMEKFRILNGSVPRSISETKFQRACCLHKSPWSLEKNRDEYLHLSGKYYQSWKYFPNMRNELIEFLNPTSIQIFGNLPISDDQNHVTCVHSRRGDFVEYLFYASDPKFMKNAVTFLNENEKVGSRNRKIVLFGDDLNFLETYFSDAVLSTDVGKNAEYYISQNPPIDDFLYSKNNCDVVLITETPKFQLPAQHSAGGLGIFRKETKFTIWILNTLGIIFLNLEVLLQVTSTHHTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>Q9BHL3</accession>
    <name>Q9BHL3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">gldi-8</name>
        <name evidence="8" type="ORF">CELE_Y111B2A.10</name>
        <name evidence="10" type="ORF">Y111B2A.10</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAC35839.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379274.1">
        <property type="nucleotide sequence ID" value="NM_001392218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9BHL3"/>
    <dbReference type="GeneID" id="176678"/>
    <dbReference type="KEGG" id="cel:CELE_Y111B2A.10"/>
    <dbReference type="UCSC" id="Y111B2A.10b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013734"/>
    <dbReference type="CTD" id="176678"/>
    <dbReference type="WormBase" id="Y111B2A.10b">
        <property type="protein sequence ID" value="CE36669"/>
        <property type="gene ID" value="WBGene00013734"/>
        <property type="gene designation" value="gldi-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052407_0_0_1"/>
    <dbReference type="OrthoDB" id="5800876at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013734">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9BHL3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC35839.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y111B2A.10b"/>
        </source>
    </evidence>
    <sequence length="312" mass="35554" checksum="93CE808779085862" modified="2004-09-13" version="2">MSQSQWKVEQKQQLEDSLLKPHTAGSIFTCVMCSKAFPNAEALQIHTDQVHDLSRLKHRCKLCGKAYKRKKNLDAHMALHLKEIQCDNCSLVFQSEKSLQSHIIRHHQEDADELEVWKAPCSICKELFPSTSVKTHEWYCKNREKIIEKQRVSKILKVQSLPSSPALSTVSYASFSSCQPGPITSPVSYRDKSCQVCGESFASRQSMLRHVGRKHPDAKNDPNVTAVRYISAESPKHPYACIECGKRFTTVTALSTHKARVHSQSNRFECTICHKSYPVPSELRKHIKRVHEKDAPKSRSALEELPEMDDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q9BHL6</accession>
    <name>Q9BHL6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">aakg-1</name>
        <name evidence="8" type="ORF">CELE_Y111B2A.8</name>
        <name evidence="10" type="ORF">Y111B2A.8</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAC35836.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370107.1">
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        <property type="gene ID" value="WBGene00013732"/>
        <property type="gene designation" value="aakg-1"/>
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    <dbReference type="OrthoDB" id="449052at2759"/>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013732">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <location>
            <begin position="221"/>
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    <feature type="domain" description="CBS" evidence="7">
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    <feature type="domain" description="CBS" evidence="7">
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            <begin position="381"/>
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        <location>
            <begin position="450"/>
            <end position="511"/>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="122"/>
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        <location>
            <begin position="131"/>
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        <location>
            <begin position="85"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="531"/>
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        <location>
            <begin position="553"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="571"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC35836.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y111B2A.8a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q9BHL6"/>
        </source>
    </evidence>
    <sequence length="582" mass="64153" checksum="D0FCF77F406EA2C6" modified="2003-10-01" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q9NHZ6-2</accession>
    <name>OAZ_CAEEL</name>
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        <recommendedName>
            <fullName>Isoform b of Ornithine decarboxylase antizyme</fullName>
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        <name evidence="2" type="primary">oaz-1</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Ecdysozoa</taxon>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="EMBO J." volume="19" first="1907" last="1917">
            <title>Conservation of polyamine regulation by translational frameshifting from yeast to mammals.</title>
            <authorList>
                <person name="Ivanov I.P."/>
                <person name="Matsufuji S."/>
                <person name="Murakami Y."/>
                <person name="Gesteland R.F."/>
                <person name="Atkins J.F."/>
            </authorList>
            <dbReference type="PubMed" id="10775274"/>
            <dbReference type="DOI" id="10.1093/emboj/19.8.1907"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
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    </reference>
    <comment type="alternative products">
        <event type="ribosomal frameshifting"/>
        <isoform>
            <id>Q9NHZ6-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_032960"/>
        </isoform>
        <isoform>
            <id>Q9NHZ6-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <text evidence="1">A ribosomal frameshift occurs between the codons for Phe-42 and Asp-43. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.</text>
    </comment>
    <dbReference type="RefSeq" id="NP_001367574.1">
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        <property type="gene ID" value="WBGene00022748"/>
        <property type="gene designation" value="oaz-1"/>
    </dbReference>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="10775274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="ZK484.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK484.1b"/>
        </source>
    </evidence>
    <sequence length="42" mass="4411" checksum="4DB26582E28B113D" modified="2000-10-01" version="1">MSSILSSNFTNKSNQLVNESAVDSSLTASPCSTQPGDVGWCF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-11-16" modified="2026-01-28" version="167" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XUK7-2</accession>
    <name>NHR85_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Nuclear hormone receptor family member nhr-85</fullName>
        </recommendedName>
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    <gene>
        <name type="primary">nhr-85</name>
        <name type="ORF">W05B5.3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="J. Mol. Evol." volume="60" first="577" last="586">
            <title>Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes.</title>
            <authorList>
                <person name="Robinson-Rechavi M."/>
                <person name="Maina C.V."/>
                <person name="Gissendanner C.R."/>
                <person name="Laudet V."/>
                <person name="Sluder A."/>
            </authorList>
            <dbReference type="PubMed" id="15983867"/>
            <dbReference type="DOI" id="10.1007/s00239-004-0175-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9XUK7-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9XUK7-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_007340"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021668.1">
        <property type="nucleotide sequence ID" value="NM_001026497.4"/>
    </dbReference>
    <dbReference type="WormBase" id="W05B5.3b">
        <property type="protein sequence ID" value="CE20150"/>
        <property type="gene ID" value="WBGene00003675"/>
        <property type="gene designation" value="nhr-85"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="336" mass="36980" checksum="FEF5FD8164B741D1" modified="2001-03-01" version="2">MSRDAVRFGRVPKREKARMFEEMQKTNVQSQRDQIAIQYENLTEVMHKINQAFGTLQATLEKCTGPIYTDRCPITSNFIVIPLKAAIDFANSIPAFLSITQTQRVHLLQNSVFDVMLLASASASTSQHFPPGGLTYDQSSANPIIPQAIQSISARIRQLPPQTVPILTAIAVCQADLLPESQQPMLLAERLWCVLGKLGGIQSLATAPSLLADVRTLRQWHSDRLRQMSQISQHFSQNLLIAPVAAAAPVLLPPAFLSPPASATSTSSSSVKSEFIERHPSIASLLERPRRISSSGAQEPLNLSLPHVRHQVKRDVDSDEQLEEMKVSPVPTTLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXE0</accession>
    <name>Q9XXE0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Brinker DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y44A6D.3</name>
        <name evidence="2 4" type="ORF">Y44A6D.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA19517.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T26896">
        <property type="entry name" value="T26896"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256953.1">
        <property type="nucleotide sequence ID" value="NM_001270024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XXE0"/>
    <dbReference type="SMR" id="Q9XXE0"/>
    <dbReference type="GeneID" id="189900"/>
    <dbReference type="KEGG" id="cel:CELE_Y44A6D.3"/>
    <dbReference type="UCSC" id="Y44A6D.3">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012854"/>
    <dbReference type="CTD" id="189900"/>
    <dbReference type="WormBase" id="Y44A6D.3a">
        <property type="protein sequence ID" value="CE31858"/>
        <property type="gene ID" value="WBGene00012854"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6502958at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012854">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XXE0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19517.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y44A6D.3a"/>
        </source>
    </evidence>
    <sequence length="229" mass="25224" checksum="A8029345026464A6" modified="2003-03-01" version="2">MSSDVRKALDPGTPYSRTLKYSIDEKLAIISHAKNHGNRAAGREFNVAESSIREWRKNENKLIHNRDAAAARLNAQSSHSSGPARLNNMNNNNNNNHNHSKNNNIQYTQTVFPRRTPDDIVKHIQIAQITQLAMMKMDFTSLARIAPFLQAHQHQQQAQAKPDSISTASSVVGTPSSISSSSSTPPPSTSPVPTSSGSGRRKPRCPMKIVVAESNNPVNIEEIQENIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXF6</accession>
    <name>Q9XXF6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">egl-23</name>
        <name evidence="12" type="ORF">CELE_Y37A1B.11</name>
        <name evidence="14" type="ORF">Y37A1B.11</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
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        <property type="entry name" value="T26616"/>
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        <property type="gene ID" value="WBGene00001190"/>
        <property type="gene designation" value="egl-23"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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            <end position="387"/>
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            <begin position="71"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="598"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="9">
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            <begin position="537"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023303"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="CAA19494.2"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
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    </evidence>
    <sequence length="691" mass="77123" checksum="719252E46564B283" modified="2003-03-01" version="2"> </sequence>
</entry>
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        <location>
            <begin position="475"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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</entry>
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        <submittedName>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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    <dbReference type="WormBase" id="F25H5.1g">
        <property type="protein sequence ID" value="CE50381"/>
        <property type="gene ID" value="WBGene00006407"/>
        <property type="gene designation" value="lim-9"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274660at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006407">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AQP4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09430">
        <property type="entry name" value="LIM5_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09432">
        <property type="entry name" value="LIM6_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000013">
        <property type="entry name" value="Four and a half LIM domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000070">
        <property type="entry name" value="Four and a half LIM domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF4">
        <property type="entry name" value="PROTEIN ESPINAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CTQ86359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F25H5.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AQP4"/>
        </source>
    </evidence>
    <sequence length="174" mass="19497" checksum="99F55D62550F1CEA" modified="2015-11-11" version="1">MKKMEYKGKQWHDKCFCCAHCKLAIGTKSFIPKNDDVFCGPCYEEKFATRCSKCKKVITAGGVTYKNEPWHRECFCCTNCNSSLAGQRFTSKDEKPYCANCYGDLFAKRCNACTKPITGIGGAKFISFEDRHWHNDCFICAQCTTSLVGKGFITDGHEILCPECAKARLMAANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AQP8</accession>
    <name>A0A0K3AQP8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_K07A12.5</name>
        <name evidence="1 3" type="ORF">K07A12.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300425.1">
        <property type="nucleotide sequence ID" value="NM_001313496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AQP8"/>
    <dbReference type="GeneID" id="187086"/>
    <dbReference type="AGR" id="WB:WBGene00010623"/>
    <dbReference type="CTD" id="187086"/>
    <dbReference type="WormBase" id="K07A12.5d">
        <property type="protein sequence ID" value="CE50403"/>
        <property type="gene ID" value="WBGene00010623"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5798077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010623">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AQP8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CTQ86364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="K07A12.5d"/>
        </source>
    </evidence>
    <sequence length="228" mass="25617" checksum="7F5CB91A414F519C" modified="2015-11-11" version="1">MKSLYAAPVDPKQTKVETMEQKEVLEPTAPMEKFVVNTTDDKRALFPASWYQQPISRSQLKKGKMIYWMAKDEEEDMTLDDDPEGKYTVTAEKLIETMTAGGKVKHAGITEPPSNTANTIMSESLASINARYKKSCERNAVFMNTLHGTIEFNKKQVSVDKTLSTSSISQDDATDAPNQIIFAPTITSHVFKGRSLKRQYAVKNKALETFEEDRKDYTREAGEETSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AQQ6</accession>
    <name>A0A0K3AQQ6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flocculation protein FLO11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_M05B5.3</name>
        <name evidence="2 4" type="ORF">M05B5.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300430.1">
        <property type="nucleotide sequence ID" value="NM_001313501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AQQ6"/>
    <dbReference type="GeneID" id="266840"/>
    <dbReference type="KEGG" id="cel:CELE_M05B5.3"/>
    <dbReference type="AGR" id="WB:WBGene00010871"/>
    <dbReference type="CTD" id="266840"/>
    <dbReference type="WormBase" id="M05B5.3a">
        <property type="protein sequence ID" value="CE50567"/>
        <property type="gene ID" value="WBGene00010871"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RWNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865339at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010871">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AQQ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="M05B5.3a"/>
        </source>
    </evidence>
    <sequence length="417" mass="45792" checksum="889915237F03C75F" modified="2015-11-11" version="1">MINAYKDEENKRKEMEFNIKRQELEPPERKRRSSSRKNKNIHIIAKPCNHVIEKNSKEVIVRQVNEVPNDEVGCSPIPRPLSQPVQPINHVQQAPPPPQQILNLQQHYQTQYVLVPVEMLRNKKIRRTRSTDVDPDTPTPQLIQQPQKLIVESVSTQTSDRSLNAGSELQKKTSEDWLSGFDDRDGERIDLDEETDEVDSDKVMKRRREFEEKKSCKRGNDHEQASSETRVSIESDAPPNPAPPPSTTPETSSTTPSTVTSSTSDPNAPTASDAASGTGTGTESSDTPASSAPPTSAASGPPAPKSNDKDSTGDKIYVKSEYCGAPGEKVTTISSNVSSQQPKSKAPAPRPSIFPYFVEPKAPSSDVSTSKASSKMTNPDPGNSGSSFALYREKQKKMATDSAKVYNGPTKKEKDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AQU4</accession>
    <name>A0A0K3AQU4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">fog-1</name>
        <name evidence="2" type="ORF">CELE_Y54E10A.4</name>
        <name evidence="4" type="ORF">Y54E10A.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300470.1">
        <property type="nucleotide sequence ID" value="NM_001313541.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AQU4"/>
    <dbReference type="SMR" id="A0A0K3AQU4"/>
    <dbReference type="GeneID" id="171895"/>
    <dbReference type="AGR" id="WB:WBGene00001481"/>
    <dbReference type="CTD" id="171895"/>
    <dbReference type="WormBase" id="Y54E10A.4d">
        <property type="protein sequence ID" value="CE50219"/>
        <property type="gene ID" value="WBGene00001481"/>
        <property type="gene designation" value="fog-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033548at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001481">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AQU4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y54E10A.4d"/>
        </source>
    </evidence>
    <sequence length="75" mass="8747" checksum="263DE314FCB3C1D0" modified="2015-11-11" version="1">MNPEAKLQQFLRMKRTNVYSNKSAYCKEAPCRQYYCPSCSNKLHSGPNQHTLLPAGKPERRPRKDKNMYLVNMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AQU9</accession>
    <name>A0A0K3AQU9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Talin central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tln-1</name>
        <name evidence="5" type="ORF">CELE_Y71G12B.11</name>
        <name evidence="7" type="ORF">Y71G12B.11</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368504.1">
        <property type="nucleotide sequence ID" value="NM_001381251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AQU9"/>
    <dbReference type="SMR" id="A0A0K3AQU9"/>
    <dbReference type="PeptideAtlas" id="A0A0K3AQU9"/>
    <dbReference type="GeneID" id="171736"/>
    <dbReference type="AGR" id="WB:WBGene00006771"/>
    <dbReference type="CTD" id="171736"/>
    <dbReference type="WormBase" id="Y71G12B.11f">
        <property type="protein sequence ID" value="CE50422"/>
        <property type="gene ID" value="WBGene00006771"/>
        <property type="gene designation" value="tln-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006771">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AQU9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10569">
        <property type="entry name" value="FERM_C_Talin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000030">
        <property type="entry name" value="TaLiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015224">
        <property type="entry name" value="Talin_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036476">
        <property type="entry name" value="Talin_cent_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054082">
        <property type="entry name" value="Talin_IBS2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049108">
        <property type="entry name" value="Talin_R4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21896">
        <property type="entry name" value="Talin_IBS2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09141">
        <property type="entry name" value="Talin_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21692">
        <property type="entry name" value="Talin_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109880">
        <property type="entry name" value="A middle domain of Talin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Talin central" evidence="2">
        <location>
            <begin position="160"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Talin IBS2B" evidence="4">
        <location>
            <begin position="331"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Talin R4" evidence="3">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CTQ86414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y71G12B.11f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AQU9"/>
        </source>
    </evidence>
    <sequence length="631" mass="70526" checksum="59DC2A0969D82B07" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR01</accession>
    <name>A0A0K3AR01_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">clh-3</name>
        <name evidence="13" type="ORF">CELE_E04F6.11</name>
        <name evidence="15" type="ORF">E04F6.11</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300530.1">
        <property type="nucleotide sequence ID" value="NM_001313601.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR01"/>
    <dbReference type="SMR" id="A0A0K3AR01"/>
    <dbReference type="GeneID" id="174187"/>
    <dbReference type="AGR" id="WB:WBGene00000530"/>
    <dbReference type="CTD" id="174187"/>
    <dbReference type="WormBase" id="E04F6.11d">
        <property type="protein sequence ID" value="CE50783"/>
        <property type="gene ID" value="WBGene00000530"/>
        <property type="gene designation" value="clh-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000530">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR01">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03683">
        <property type="entry name" value="ClC_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000048">
        <property type="entry name" value="Chloride channel 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000022">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000064">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF10">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8 10" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="622"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="696"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CTQ86469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="E04F6.11d"/>
        </source>
    </evidence>
    <sequence length="1063" mass="117945" checksum="22BC0F0FF79928D3" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR06</accession>
    <name>A0A0K3AR06_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">clh-3</name>
        <name evidence="13" type="ORF">CELE_E04F6.11</name>
        <name evidence="15" type="ORF">E04F6.11</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300535.1">
        <property type="nucleotide sequence ID" value="NM_001313606.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR06"/>
    <dbReference type="SMR" id="A0A0K3AR06"/>
    <dbReference type="GeneID" id="174187"/>
    <dbReference type="AGR" id="WB:WBGene00000530"/>
    <dbReference type="CTD" id="174187"/>
    <dbReference type="WormBase" id="E04F6.11i">
        <property type="protein sequence ID" value="CE50810"/>
        <property type="gene ID" value="WBGene00000530"/>
        <property type="gene designation" value="clh-3"/>
    </dbReference>
    <dbReference type="OMA" id="ACFMFNN"/>
    <dbReference type="OrthoDB" id="4564at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000530">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR06">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03683">
        <property type="entry name" value="ClC_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chloride channel 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000022">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000064">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF10">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0129">CBS domain</keyword>
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    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="634"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="708"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CTQ86474.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="E04F6.11i"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121097" checksum="5A2A756B18DA1746" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR10</accession>
    <name>A0A0K3AR10_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DDT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">nurf-1</name>
        <name evidence="15" type="ORF">CELE_F26H11.2</name>
        <name evidence="17" type="ORF">F26H11.2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300540.1">
        <property type="nucleotide sequence ID" value="NM_001313611.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0K3AR10"/>
    <dbReference type="GeneID" id="175098"/>
    <dbReference type="AGR" id="WB:WBGene00009180"/>
    <dbReference type="CTD" id="175098"/>
    <dbReference type="WormBase" id="F26H11.2n">
        <property type="protein sequence ID" value="CE51014"/>
        <property type="gene ID" value="WBGene00009180"/>
        <property type="gene designation" value="nurf-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009180">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
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    <dbReference type="SUPFAM" id="SSF47370">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DDT" evidence="14">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="1901"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="1961"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="2049"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1093"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1160"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1415"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1659"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1836"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1160"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1667"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1854"/>
            <end position="1863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CTQ86479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="F26H11.2n"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AR10"/>
        </source>
    </evidence>
    <sequence length="2196" mass="252424" checksum="B1193BF7471DFA7E" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR16</accession>
    <name>A0A0K3AR16_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">chs-2</name>
        <name evidence="16" type="ORF">CELE_F48A11.1</name>
        <name evidence="18" type="ORF">F48A11.1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 19">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300545.1">
        <property type="nucleotide sequence ID" value="NM_001313616.3"/>
    </dbReference>
    <dbReference type="GeneID" id="173405"/>
    <dbReference type="AGR" id="WB:WBGene00000497"/>
    <dbReference type="CTD" id="173405"/>
    <dbReference type="WormBase" id="F48A11.1c">
        <property type="protein sequence ID" value="CE50769"/>
        <property type="gene ID" value="WBGene00000497"/>
        <property type="gene designation" value="chs-2"/>
    </dbReference>
    <dbReference type="OMA" id="SMANQRC"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000497">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR16">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000139">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055120">
        <property type="entry name" value="Chs-1/2_IV_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF42">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23000">
        <property type="entry name" value="ChitinSynthase_IV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1070"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1107"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1134"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1168"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1197"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1410"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1473"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase chs-1/2 N-terminal putative transporter" evidence="15">
        <location>
            <begin position="142"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1224"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1657"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1660"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1679"/>
            <end position="1693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CTQ86484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="F48A11.1c"/>
        </source>
    </evidence>
    <sequence length="1700" mass="194500" checksum="103612CA382ED254" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR32</accession>
    <name>A0A0K3AR32_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">gskl-1</name>
        <name evidence="2" type="ORF">CELE_R03D7.5</name>
        <name evidence="4" type="ORF">R03D7.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300575.1">
        <property type="nucleotide sequence ID" value="NM_001313646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR32"/>
    <dbReference type="SMR" id="A0A0K3AR32"/>
    <dbReference type="GeneID" id="187536"/>
    <dbReference type="AGR" id="WB:WBGene00010991"/>
    <dbReference type="CTD" id="187536"/>
    <dbReference type="WormBase" id="R03D7.5b">
        <property type="protein sequence ID" value="CE50374"/>
        <property type="gene ID" value="WBGene00010991"/>
        <property type="gene designation" value="gskl-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5792074at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010991">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR32">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R03D7.5b"/>
        </source>
    </evidence>
    <sequence length="92" mass="10597" checksum="61FCB1E2C2239CFE" modified="2015-11-11" version="1">MLDSEIYDFMKATLKIDPKKRKSAIDVLKMPLFDILRSSPPKKRSNGVEMPNLASYTEMHHKREPETEVVADIQTTEKAEKESDSTNEELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR37</accession>
    <name>A0A0K3AR37_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">etr-1</name>
        <name evidence="5" type="ORF">CELE_T01D1.2</name>
        <name evidence="7" type="ORF">T01D1.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368525.1">
        <property type="nucleotide sequence ID" value="NM_001381299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR37"/>
    <dbReference type="SMR" id="A0A0K3AR37"/>
    <dbReference type="PeptideAtlas" id="A0A0K3AR37"/>
    <dbReference type="GeneID" id="173401"/>
    <dbReference type="AGR" id="WB:WBGene00001340"/>
    <dbReference type="CTD" id="173401"/>
    <dbReference type="WormBase" id="T01D1.2p">
        <property type="protein sequence ID" value="CE50615"/>
        <property type="gene ID" value="WBGene00001340"/>
        <property type="gene designation" value="etr-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001340">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR37">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12362">
        <property type="entry name" value="RRM3_CELF1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000569">
        <property type="entry name" value="ELAV-Type RNA binding-protein family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="337"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CTQ86519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="T01D1.2p"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AR37"/>
        </source>
    </evidence>
    <sequence length="422" mass="44444" checksum="BCF908C8AB02BFE3" modified="2015-11-11" version="1">MNENFSSASSARSTTRRICVRFLPNSAILKIVVCFVIRTEKVEGCSAPLVVKFADTQKDKDVKTKSMITGSGAGSPKGGAASLLQNLNPALLQQLGGGQNYQAVASLLSLINGQQGQQQQHQQQQNVLGILGTGNPLLGNPAMAAQNQFDAITMAQIAHQQQMLALQGFAVQQGAPSQQQQGLFLAHQYSTNYSTGSPDSASNATDSSSDDNNVMNNRLTPTSKMAQYGYGPLIPRHPAQLYLQQRFPATAAAYVPGLAGGMAGAKTTSPVAASLANHQQIALTPFAGGAAALDHFQAMQQYALLANLQATGGVGVQATTSAAQMVGNGDVKGPDGANLFIYHLPQDFGDSDLINTFAPFGGILSAKVFIDKVTNLSKCFGFVSYENAQSATNAISAMNGFQIGSKRLKVQLKVDRGNPYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR60</accession>
    <name>A0A0K3AR60_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CELE_Y43H11AL.1</name>
        <name evidence="12 14" type="ORF">Y43H11AL.1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300600.1">
        <property type="nucleotide sequence ID" value="NM_001313671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR60"/>
    <dbReference type="SMR" id="A0A0K3AR60"/>
    <dbReference type="GeneID" id="173408"/>
    <dbReference type="AGR" id="WB:WBGene00021545"/>
    <dbReference type="CTD" id="173408"/>
    <dbReference type="WormBase" id="Y43H11AL.1c">
        <property type="protein sequence ID" value="CE50855"/>
        <property type="gene ID" value="WBGene00021545"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021545">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR60">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001057">
        <property type="entry name" value="Protein CBG07029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF79">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="424"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CTQ86539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="Y43H11AL.1c"/>
        </source>
    </evidence>
    <sequence length="476" mass="54566" checksum="F386D28F1510DF39" modified="2015-11-11" version="1">MEGMNEEMTKRLARVTKWDEQIDVDSAEAQKFEKIMFDTQKSEKERVEAGRKLADLKCRIRELAEKKTLLAERNHRTVQAVYTKLNELAYHCKCELETDNPGSTEQRERVFYQTLDKNYRGEYQSSIPNVRTTNSGRQRTREYSVMTDDDRASTSSGTLFTKREKSSLKKGPGRPRNAFKMAHFDRFPVDSNASSARSSMEPSECGGSQNTKKLSKYMKKKNEKMRKEEQKLSKFDVKREVDTGDYESFALNQWNNDDDMGMTSSKMMNGSSLMELCEEEEAELLDCFAGLPSPPRGMMDVLDVTESDVCGMDLYPKDHKSENYDDFRHPGASAMSSQSFTHKRANNAARAPPAVATAAAVSSFSDSTIIRYEKQRSHTPPQRNTLFGSISDTSFSGRPRKLTDRVTEMIISNRERTKKYREQEEWCICNGMNINSGMMVECENKNCPIKWFHFECVGLLAAPLDEWYCTDCNPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR63</accession>
    <name>A0A0K3AR63_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Forkhead box protein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">daf-16</name>
        <name evidence="15" type="ORF">CELE_R13H8.1</name>
        <name evidence="17" type="ORF">R13H8.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368499.1">
        <property type="nucleotide sequence ID" value="NM_001381207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR63"/>
    <dbReference type="SMR" id="A0A0K3AR63"/>
    <dbReference type="GeneID" id="172981"/>
    <dbReference type="AGR" id="WB:WBGene00000912"/>
    <dbReference type="CTD" id="172981"/>
    <dbReference type="WormBase" id="R13H8.1k">
        <property type="protein sequence ID" value="CE50782"/>
        <property type="gene ID" value="WBGene00000912"/>
        <property type="gene designation" value="daf-16"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
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        <property type="expression patterns" value="Expressed in larva and 5 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="InterPro" id="IPR036388">
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    <dbReference type="InterPro" id="IPR036390">
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    <dbReference type="PANTHER" id="PTHR45767">
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    </dbReference>
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        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="FORK_HEAD_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="14">
        <location>
            <begin position="119"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="12">
        <location>
            <begin position="119"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="64"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CTQ86342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="R13H8.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AR63"/>
        </source>
    </evidence>
    <sequence length="485" mass="53229" checksum="4EB8976735094B2A" modified="2015-11-11" version="1">MSFSTDFDDDFFNLDLHQQERSASFGGVTQYSQQFLREKCSFSPYFHTSLETVDSGRTSLYGSNEQCGQLGGASSNGSTAMLHTPDGSNSHQTSFPSEMSESPDDTVSGKKTTTRRNAWGNMSYAELITTAIMASPEKRLTLAQVYEWMVQNVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFMRIQNEGAGKSSWWVINPDAKPGRNPRRTRERSNTIETTTKAQLEKSRRGAKKRIKERALMGSLHSTLNGNSIAGSIQTISHDLYDDDSMQGAFDNVPSSFRPRTQSNLSIPGSSSRVSPAIGSDIYDDLEFPSWVGESVPAIPSDIVDRTDQMRIDATTHIGGVQIKQESKPIKTEPIAPPPSYHELNSVRGSCAQNPLLRNPIVPSTNFKPMPLPGAYGNYQNGGITPINWLSTSNSSPLPGIQSCGIVAAQHTVASSSALPIDLENLTLPDQPLMDTMDVDALIRHELSQAGGQHIHFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR68</accession>
    <name>A0A0K3AR68_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">unc-75</name>
        <name evidence="8" type="ORF">C17D12.2</name>
        <name evidence="6" type="ORF">CELE_C17D12.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300408.1">
        <property type="nucleotide sequence ID" value="NM_001313479.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR68"/>
    <dbReference type="GeneID" id="182722"/>
    <dbReference type="AGR" id="WB:WBGene00006807"/>
    <dbReference type="CTD" id="182722"/>
    <dbReference type="WormBase" id="C17D12.2c">
        <property type="protein sequence ID" value="CE50818"/>
        <property type="gene ID" value="WBGene00006807"/>
        <property type="gene designation" value="unc-75"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006807">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR68">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12635">
        <property type="entry name" value="RRM2_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12639">
        <property type="entry name" value="RRM3_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUGBP Elav-like family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001495">
        <property type="entry name" value="Protein CBR-UNC-75"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="331"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CTQ86347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="C17D12.2c"/>
        </source>
    </evidence>
    <sequence length="416" mass="44837" checksum="2B087845AECA3489" modified="2015-11-11" version="1">MNRAMQVKPADTDSRPASPKDKMDDKKLFIGMLSKQQSEDEVRALFATFGELDEVTVLRGADGASKGCAFVKYKHGLDAHMAISALHGSQTMPGASSSLVVKYADTEKERQNRRMQQMAAQMGMLNPMLVNQVGMQYNAYQQVLQQQSLAAQTNAMASAAYLPLLQQQTTDPLHVLQLQAAAAAAQAAANPVLSQQTQQQQQQQQQLAAQLQLQSAAAQNPHYALAAQALAQQQAAQQAQAVVAHSHAQVHQHQTAQVTSTASHAQTENPAASSYGSLAAAAAAANYSSLLSGMESQHNAAAALQLAQIQQQAAAALPMVTPREVLGPDGCNLFIYHLPQEFGDAELIQMFAPFGHIVSAKVFVDRATNQSKCFGFVSYDNIHSSQAAITAMNGFQIGMKRLKVQLKRPRNESRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR72</accession>
    <name>A0A0K3AR72_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FH1/FH2 domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fhod-1</name>
        <name evidence="8" type="ORF">C46H11.11</name>
        <name evidence="6" type="ORF">CELE_C46H11.11</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300413.1">
        <property type="nucleotide sequence ID" value="NM_001313484.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR72"/>
    <dbReference type="SMR" id="A0A0K3AR72"/>
    <dbReference type="GeneID" id="172133"/>
    <dbReference type="KEGG" id="cel:CELE_C46H11.11"/>
    <dbReference type="AGR" id="WB:WBGene00016735"/>
    <dbReference type="CTD" id="172133"/>
    <dbReference type="WormBase" id="C46H11.11b">
        <property type="protein sequence ID" value="CE50953"/>
        <property type="gene ID" value="WBGene00016735"/>
        <property type="gene designation" value="fhod-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9806920at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016735">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR72">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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            <authorList>
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                <person name="Downs W.D."/>
                <person name="Lin R."/>
                <person name="Wittmann C."/>
                <person name="Bei Y."/>
                <person name="Cha Y.-H."/>
                <person name="Ali M."/>
                <person name="Priess J.R."/>
                <person name="Mello C.C."/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
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        <citation type="journal article" date="2003" name="Development" volume="130" first="3547" last="3556">
            <title>Establishment of POP-1 asymmetry in early C. elegans embryos.</title>
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                <person name="Priess J.R."/>
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            <dbReference type="DOI" id="10.1242/dev.00563"/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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        <citation type="journal article" date="2005" name="Dev. Biol." volume="284" first="246" last="259">
            <title>MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions.</title>
            <authorList>
                <person name="Hawkins N.C."/>
                <person name="Ellis G.C."/>
                <person name="Bowerman B."/>
                <person name="Garriga G."/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="2" key="7">
        <citation type="journal article" date="2005" name="Dev. Biol." volume="285" first="447" last="461">
            <title>The C. elegans Frizzled CFZ-2 is required for cell migration and interacts with multiple Wnt signaling pathways.</title>
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                <person name="Zinovyeva A.Y."/>
                <person name="Forrester W.C."/>
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            <dbReference type="PubMed" id="16109397"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2005.07.014"/>
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        <scope>FUNCTION</scope>
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    <reference evidence="2" key="8">
        <citation type="journal article" date="2006" name="Dev. Biol." volume="298" first="442" last="457">
            <title>Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development.</title>
            <authorList>
                <person name="Gleason J.E."/>
                <person name="Szyleyko E.A."/>
                <person name="Eisenmann D.M."/>
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            <dbReference type="DOI" id="10.1016/j.ydbio.2006.06.050"/>
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        <scope>FUNCTION</scope>
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    <reference evidence="2" key="9">
        <citation type="journal article" date="2006" name="Dev. Cell" volume="10" first="367" last="377">
            <title>Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Pan C.L."/>
                <person name="Howell J.E."/>
                <person name="Clark S.G."/>
                <person name="Hilliard M."/>
                <person name="Cordes S."/>
                <person name="Bargmann C.I."/>
                <person name="Garriga G."/>
            </authorList>
            <dbReference type="PubMed" id="16516839"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2006.02.010"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="10">
        <citation type="journal article" date="2010" name="PLoS Biol." volume="8" first="E1000297" last="E1000297">
            <title>The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.</title>
            <authorList>
                <person name="Cabello J."/>
                <person name="Neukomm L.J."/>
                <person name="Guenesdogan U."/>
                <person name="Burkart K."/>
                <person name="Charette S.J."/>
                <person name="Lochnit G."/>
                <person name="Hengartner M.O."/>
                <person name="Schnabel R."/>
            </authorList>
            <dbReference type="PubMed" id="20126385"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.1000297"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="11">
        <citation type="journal article" date="2011" name="PLoS Genet." volume="7" first="E1002308" last="E1002308">
            <title>Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells.</title>
            <authorList>
                <person name="Yamamoto Y."/>
                <person name="Takeshita H."/>
                <person name="Sawa H."/>
            </authorList>
            <dbReference type="PubMed" id="22022276"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002308"/>
        </citation>
        <scope>FUNCTION</scope>
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    <reference evidence="2" key="12">
        <citation type="journal article" date="2013" name="Mol. Syst. Biol." volume="9" first="631" last="631">
            <title>Deconvolving the roles of Wnt ligands and receptors in sensing and amplification.</title>
            <authorList>
                <person name="Tan R.Z."/>
                <person name="Ji N."/>
                <person name="Mentink R.A."/>
                <person name="Korswagen H.C."/>
                <person name="van Oudenaarden A."/>
            </authorList>
            <dbReference type="PubMed" id="23295860"/>
            <dbReference type="DOI" id="10.1038/msb.2012.64"/>
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        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="2" key="13">
        <citation type="journal article" date="2014" name="Dev. Cell" volume="31" first="188" last="201">
            <title>Cell intrinsic modulation of Wnt signaling controls neuroblast migration in C. elegans.</title>
            <authorList>
                <person name="Mentink R.A."/>
                <person name="Middelkoop T.C."/>
                <person name="Rella L."/>
                <person name="Ji N."/>
                <person name="Tang C.Y."/>
                <person name="Betist M.C."/>
                <person name="van Oudenaarden A."/>
                <person name="Korswagen H.C."/>
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            <dbReference type="PubMed" id="25373777"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2014.08.008"/>
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        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
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    <reference evidence="2" key="14">
        <citation type="journal article" date="2014" name="Development" volume="141" first="617" last="628">
            <title>The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.</title>
            <authorList>
                <person name="Moffat L.L."/>
                <person name="Robinson R.E."/>
                <person name="Bakoulis A."/>
                <person name="Clark S.G."/>
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            <dbReference type="PubMed" id="24401370"/>
            <dbReference type="DOI" id="10.1242/dev.101600"/>
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        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF LYS-343; LYS-430; LYS-442; LYS-445; LYS-541 AND LYS-548</scope>
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    <reference evidence="2" key="15">
        <citation type="journal article" date="2015" name="Dev. Biol." volume="404" first="55" last="65">
            <title>Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1.</title>
            <authorList>
                <person name="Chien S.C."/>
                <person name="Gurling M."/>
                <person name="Kim C."/>
                <person name="Craft T."/>
                <person name="Forrester W."/>
                <person name="Garriga G."/>
            </authorList>
            <dbReference type="PubMed" id="25917219"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2015.04.015"/>
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        <scope>FUNCTION</scope>
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    <reference evidence="2" key="16">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005446" last="E1005446">
            <title>The Wnt frizzled receptor MOM-5 regulates the UNC-5 Netrin receptor through small GTPase-dependent signaling to determine the polarity of migrating cells.</title>
            <authorList>
                <person name="Levy-Strumpf N."/>
                <person name="Krizus M."/>
                <person name="Zheng H."/>
                <person name="Brown L."/>
                <person name="Culotti J.G."/>
            </authorList>
            <dbReference type="PubMed" id="26292279"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005446"/>
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        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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            <dbReference type="EMBL" id="AAC47750.1"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000561">
        <property type="entry name" value="Protein CBG19271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="19"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SOF58845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F36D4.4b"/>
        </source>
    </evidence>
    <sequence length="454" mass="51851" checksum="4B57C10ACE2EF24D" modified="2017-12-20" version="1">MATTAVFLCGHLGALSVILNLFVIIALLRHRRRVLSNVFYVIVLHCAVLDVARGVCLILYGLPYFANSFYNINLDIHTRIHLFQLSRFALVILRVCNLLTIFNLLVFTTNEYIVIRYPLHYRRYFRRKFVLIILAICWTMSIMMALGILYSSSKSQTEWLPPEERGIDFATITMVLISSLCFVTLGTVVICYISILRTIRKFKDEGCLNNDESHRIHNRSLHRPINGQGSNCSNGSSLRGSKWRSVQAMSRHKYIYVIGSVLIVDLLFLCPYSGIQMVSFLHINNFLQITHGSTLIRWWLQVLIGVHSVCQPLCYFRMTEFRRLACCNPRRPWNRTKSFSQMNKSFANTRSNVREDENGNNTAEIEVTPNEPLLRNGENGGTPSRRSPTIAWTRGESVRFRTYGNEIGHHIPTKKNESKEPQCEIEMIPISTGSASPSDDSAVQIPIIDDSPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3C9</accession>
    <name>A0A2C9C3C9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein Rab-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">unc-108</name>
        <name evidence="3" type="ORF">CELE_F53F10.4</name>
        <name evidence="5" type="ORF">F53F10.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SOF58717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343726.1">
        <property type="nucleotide sequence ID" value="NM_001356805.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3C9"/>
    <dbReference type="SMR" id="A0A2C9C3C9"/>
    <dbReference type="GeneID" id="171956"/>
    <dbReference type="AGR" id="WB:WBGene00006833"/>
    <dbReference type="CTD" id="171956"/>
    <dbReference type="WormBase" id="F53F10.4c">
        <property type="protein sequence ID" value="CE52077"/>
        <property type="gene ID" value="WBGene00006833"/>
        <property type="gene designation" value="unc-108"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006833">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3C9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002360">
        <property type="entry name" value="Ras-related protein Rab-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SOF58717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F53F10.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3C9"/>
        </source>
    </evidence>
    <sequence length="168" mass="18396" checksum="A4ECEB6EF233D80F" modified="2017-12-20" version="1">MVTIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTSWLEDARQHSNSNMVIMLIGNKSDLEARREVKREEGEAFAREHGLVFMETSAKTAANVEEAFIDTAKEIYRKIQEGVFDINNEANGIKLGPQHSPSSPNSPGGNATGGLGGGSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3E0</accession>
    <name>A0A2C9C3E0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serpentine Receptor, class D (Delta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">srd-8</name>
        <name evidence="9" type="ORF">B0547.4</name>
        <name evidence="7" type="ORF">CELE_B0547.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode receptor-like protein srd family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="SOF58797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343801.1">
        <property type="nucleotide sequence ID" value="NM_001356923.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3E0"/>
    <dbReference type="SMR" id="A0A2C9C3E0"/>
    <dbReference type="GeneID" id="191798"/>
    <dbReference type="KEGG" id="cel:CELE_B0547.4"/>
    <dbReference type="AGR" id="WB:WBGene00005086"/>
    <dbReference type="CTD" id="191798"/>
    <dbReference type="WormBase" id="B0547.4b">
        <property type="protein sequence ID" value="CE52074"/>
        <property type="gene ID" value="WBGene00005086"/>
        <property type="gene designation" value="srd-8"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5793097at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3E0">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019421">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050920">
        <property type="entry name" value="Nematode_rcpt-like_delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22945:SF21">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS D (DELTA)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22945">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS D DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10317">
        <property type="entry name" value="7TM_GPCR_Srd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SOF58797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="B0547.4b"/>
        </source>
    </evidence>
    <sequence length="173" mass="19804" checksum="F86B4EB1E0DBD934" modified="2017-12-20" version="1">MLFQKMDLDEVETALKDRFPQFNFTGLAVTGAIDIIGFATLYTLIHMTIISIPLAIGIQILRRKIINLLVLKGVDLTTKSRNLHAQLLRTLTFQATVPLIYFLDVFFFFLTHIWNNPILEFSIIIPSLIVPILIPISSLIYVTPYRNYVLRFFSLRPGLQAVNSQSIIPVIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3E1</accession>
    <name>A0A2C9C3E1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_M03F8.6</name>
        <name evidence="2 4" type="ORF">M03F8.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3E1"/>
    <dbReference type="SMR" id="A0A2C9C3E1"/>
    <dbReference type="AGR" id="WB:WBGene00019765"/>
    <dbReference type="WormBase" id="M03F8.6b">
        <property type="protein sequence ID" value="CE52344"/>
        <property type="gene ID" value="WBGene00019765"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5861496at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019765">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3E1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013379173" evidence="1">
        <location>
            <begin position="17"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="M03F8.6b"/>
        </source>
    </evidence>
    <sequence length="226" mass="26586" checksum="402A971A3A595451" modified="2017-12-20" version="1">MIFFYTILCLLPSLSASAIDEDLIIERRPHHVDWEDLFMEYNKYSAPDRSRQEVNLTLEIIDISFHRVLFELVQTWRDERLRFVGSVRVPVPSHIQPWYPDTYIRNGWDVIVEQKSLELNYDGTFSLRQKYQATLDLDEKNKLDLTLVISSFNNYGTERINYNLISSKSEVKNYEHISLHKVSRKSDNIYFDDLHIGIHYSPVISQPTTTQKYESSTLAQSNNSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3E2</accession>
    <name>A0A2C9C3E2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD Repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">wdr-62</name>
        <name evidence="2" type="ORF">CELE_H24G06.1</name>
        <name evidence="4" type="ORF">H24G06.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343852.1">
        <property type="nucleotide sequence ID" value="NM_001356733.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3E2"/>
    <dbReference type="SMR" id="A0A2C9C3E2"/>
    <dbReference type="GeneID" id="179326"/>
    <dbReference type="AGR" id="WB:WBGene00019237"/>
    <dbReference type="CTD" id="179326"/>
    <dbReference type="WormBase" id="H24G06.1g">
        <property type="protein sequence ID" value="CE52263"/>
        <property type="gene ID" value="WBGene00019237"/>
        <property type="gene designation" value="wdr-62"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6154712at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019237">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3E2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="H24G06.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3E2"/>
        </source>
    </evidence>
    <sequence length="594" mass="65283" checksum="6E2ACDEBCC4EE1EF" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3E6</accession>
    <name>A0A2C9C3E6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4150 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_K02E11.4</name>
        <name evidence="1 3" type="ORF">K02E11.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3E6"/>
    <dbReference type="AGR" id="WB:WBGene00010513"/>
    <dbReference type="WormBase" id="K02E11.4e">
        <property type="protein sequence ID" value="CE52251"/>
        <property type="gene ID" value="WBGene00010513"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5781203at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010513">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3E6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35182">
        <property type="entry name" value="PROTEIN CBG13762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35182:SF4">
        <property type="entry name" value="SCP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SOF58859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="K02E11.4e"/>
        </source>
    </evidence>
    <sequence length="69" mass="7701" checksum="9D8927C7F66E2487" modified="2017-12-20" version="1">MPGGGGMMYGKVNATVTISLPNKKKVPSGVTTYNKNKKALIIKKMRLEDFGDYMTGNKKTKLFVMNQTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3E7</accession>
    <name>A0A2C9C3E7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">jun-1</name>
        <name evidence="7" type="ORF">CELE_T24H10.7</name>
        <name evidence="9" type="ORF">T24H10.7</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Jun subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343786.1">
        <property type="nucleotide sequence ID" value="NM_001356881.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3E7"/>
    <dbReference type="SMR" id="A0A2C9C3E7"/>
    <dbReference type="GeneID" id="174452"/>
    <dbReference type="AGR" id="WB:WBGene00012005"/>
    <dbReference type="CTD" id="174452"/>
    <dbReference type="WormBase" id="T24H10.7g">
        <property type="protein sequence ID" value="CE52210"/>
        <property type="gene ID" value="WBGene00012005"/>
        <property type="gene designation" value="jun-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2187714at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012005">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3E7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14696">
        <property type="entry name" value="bZIP_Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SOF58778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="T24H10.7g"/>
        </source>
    </evidence>
    <sequence length="175" mass="19355" checksum="ECC16C8480497691" modified="2017-12-20" version="1">MKILASSAIPGPPIISSSNSPDSSTTAVTTSQITAFQPLLNNFVSSTTASTSRPDKLNLTPPQQSAEIYAFNGVNSDDSDGGLDSRSASRCGMALDDQEKKKLERKRARNRQAATKCRQKKMDRIKELEEQVLHEKHRGQRLDAELLELNRALEHFRRTVEHHSGNGCPNNSIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3F1</accession>
    <name>A0A2C9C3F1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Ryanodine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">unc-68</name>
        <name evidence="20" type="ORF">CELE_K11C4.5</name>
        <name evidence="22" type="ORF">K11C4.5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343810.1">
        <property type="nucleotide sequence ID" value="NM_001356678.4"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2C9C3F1"/>
    <dbReference type="GeneID" id="179080"/>
    <dbReference type="AGR" id="WB:WBGene00006801"/>
    <dbReference type="CTD" id="179080"/>
    <dbReference type="WormBase" id="K11C4.5g">
        <property type="protein sequence ID" value="CE52299"/>
        <property type="gene ID" value="WBGene00006801"/>
        <property type="gene designation" value="unc-68"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300855at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006801">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3F1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23278">
        <property type="entry name" value="beta-trefoil_MIR_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12877">
        <property type="entry name" value="SPRY1_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12878">
        <property type="entry name" value="SPRY2_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBN-UNC-68 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein CBR-LIPL-6"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ryanodine receptor 44F"/>
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    </dbReference>
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        <property type="entry name" value="ryanodine receptor isoform X2"/>
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        <property type="entry name" value="ryanodine receptor isoform X2"/>
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        <property type="entry name" value="ryanodine receptor isoform X2"/>
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    </dbReference>
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        <property type="entry name" value="Ryanodine receptor, isoform E"/>
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        <property type="entry name" value="Ryanodine receptor, isoform E"/>
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    </dbReference>
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        <property type="entry name" value="Ryanodine receptor, isoform F"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="3"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035761">
        <property type="entry name" value="SPRY1_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035764">
        <property type="entry name" value="SPRY2_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035762">
        <property type="entry name" value="SPRY3_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4553"/>
            <end position="4576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4739"/>
            <end position="4756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4802"/>
            <end position="4824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4940"/>
            <end position="4962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4982"/>
            <end position="5007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="5067"/>
            <end position="5086"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="19">
        <location>
            <begin position="104"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="582"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="1006"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="1477"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="4299"/>
            <end position="4334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1328"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3599"/>
            <end position="3618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="4643"/>
            <end position="4685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1345"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1364"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1395"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1430"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1459"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="3599"/>
            <end position="3610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="4649"/>
            <end position="4666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SOF58808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="K11C4.5g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3F1"/>
        </source>
    </evidence>
    <sequence length="5188" mass="589093" checksum="9C945720A4BB492B" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3F6</accession>
    <name>A0A2C9C3F6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M16 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ucr-1</name>
        <name evidence="4" type="ORF">CELE_F56D2.1</name>
        <name evidence="6" type="ORF">F56D2.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SOF58790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368667.1">
        <property type="nucleotide sequence ID" value="NM_001379716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3F6"/>
    <dbReference type="SMR" id="A0A2C9C3F6"/>
    <dbReference type="GeneID" id="175772"/>
    <dbReference type="AGR" id="WB:WBGene00018963"/>
    <dbReference type="CTD" id="175772"/>
    <dbReference type="WormBase" id="F56D2.1d">
        <property type="protein sequence ID" value="CE52277"/>
        <property type="gene ID" value="WBGene00018963"/>
        <property type="gene designation" value="ucr-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018963">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3F6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF143">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="25"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SOF58790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F56D2.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3F6"/>
        </source>
    </evidence>
    <sequence length="298" mass="33115" checksum="52FEB14D6D1AD6BD" modified="2017-12-20" version="1">MLHAAGFQGTPLALSVLGTSESIPNISAQQLKEWQEDHYRPVRMVLSAVGGGVSNVSSLADKYFGDLSNEYPRKVPQVDGTRFTGSEYRYRNDNVPHMYAAFAVEGVGYAHKDALALQIANQFIVLGQWDVTHATSRTAASRLVQKIGHDHGVHNLQHFNINYKDTGLFGIYFVADAHDLNDTSGIMKSVAHEWKHLASAATEEEVAMAKNQFRTNLYQNLETNTQKAGFNAKELLYTGNLRQLSELEAQIQKVDAGAVREAISRHVYDRDLAAVGVGRTEAFPNYALTRAGMSWWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3G0</accession>
    <name>A0A2C9C3G0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">vhp-1</name>
        <name evidence="8" type="ORF">CELE_F08B1.1</name>
        <name evidence="10" type="ORF">F08B1.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001427168.1">
        <property type="nucleotide sequence ID" value="NM_001440237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3G0"/>
    <dbReference type="SMR" id="A0A2C9C3G0"/>
    <dbReference type="GeneID" id="173904"/>
    <dbReference type="AGR" id="WB:WBGene00006923"/>
    <dbReference type="CTD" id="173904"/>
    <dbReference type="WormBase" id="F08B1.1g">
        <property type="protein sequence ID" value="CE52069"/>
        <property type="gene ID" value="WBGene00006923"/>
        <property type="gene designation" value="vhp-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006923">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3G0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF533">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE VHP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="157"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SOF58747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F08B1.1g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3G0"/>
        </source>
    </evidence>
    <sequence length="448" mass="47587" checksum="AB96F390AAEE5309" modified="2017-12-20" version="1">MTCPKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIKDHVLDYNQASRPHRHMDYYGPSDLCPPKVPKSASSNCVFPGSTHDESSPSSPSVSEGSAASEPETSSSAASSSSTASAPPSMPSTSEQGTSSGTVNVNGKRNMTMDLGLPHRPKALGLPSRIGTSVAELPSPSTELSRLSFNGPEAIAPSTPILNFTNPCFNSPIIPVASSSREVILTLPTPAASSSSSTSSEPSFDFSSFESSSSSSIVVENPFFASTEVPAGSSSISTPSGSQSTPASASSSAASRCRMKGFFKVFSKKAPASTSTPASSTPGTSRAARPECLRSSGIIISAPVLAITEEEDAESPESGFNEPEVGEEDDDSVSICSTSSLEIPCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3G1</accession>
    <name>A0A2C9C3G1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Ryanodine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">unc-68</name>
        <name evidence="20" type="ORF">CELE_K11C4.5</name>
        <name evidence="22" type="ORF">K11C4.5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="WormBase" id="K11C4.5o"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3G1"/>
        </source>
    </evidence>
    <sequence length="5186" mass="589073" checksum="9F58358E430F9C1D" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3G3</accession>
    <name>A0A2C9C3G3_CAEEL</name>
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        <submittedName>
            <fullName evidence="12">Neprilysin-2</fullName>
        </submittedName>
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    <gene>
        <name evidence="12 14" type="primary">nep-21</name>
        <name evidence="12" type="ORF">CELE_T16A9.4</name>
        <name evidence="14" type="ORF">T16A9.4</name>
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    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
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    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343820.1">
        <property type="nucleotide sequence ID" value="NM_001356755.4"/>
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    <dbReference type="AGR" id="WB:WBGene00011794"/>
    <dbReference type="CTD" id="179925"/>
    <dbReference type="WormBase" id="T16A9.4c">
        <property type="protein sequence ID" value="CE52240"/>
        <property type="gene ID" value="WBGene00011794"/>
        <property type="gene designation" value="nep-21"/>
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    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011794">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3G3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
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        <property type="entry name" value="Peptidase_M13_C"/>
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    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
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    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF192">
        <property type="entry name" value="NEPRILYSIN-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="195"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="648"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SOF58818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T16A9.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3G3"/>
        </source>
    </evidence>
    <sequence length="856" mass="98052" checksum="55862B7E80A6C20B" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3H3</accession>
    <name>A0A2C9C3H3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">egl-44</name>
        <name evidence="11" type="ORF">CELE_F28B12.2</name>
        <name evidence="13" type="ORF">F28B12.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001356848.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3H3"/>
    <dbReference type="SMR" id="A0A2C9C3H3"/>
    <dbReference type="GeneID" id="174005"/>
    <dbReference type="AGR" id="WB:WBGene00001208"/>
    <dbReference type="CTD" id="174005"/>
    <dbReference type="WormBase" id="F28B12.2g">
        <property type="protein sequence ID" value="CE52405"/>
        <property type="gene ID" value="WBGene00001208"/>
        <property type="gene designation" value="egl-44"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001208">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3H3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="10">
        <location>
            <begin position="87"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="8">
        <location>
            <begin position="87"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SOF58757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F28B12.2g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3H3"/>
        </source>
    </evidence>
    <sequence length="492" mass="54428" checksum="BE3DC6D3BFAC5882" modified="2017-12-20" version="1">MSSIFPNLLPFQLFMSEDVAVTAQTILNGTPPHNHFRKEWLAGAAGTTTPTTTSGGQMMTLSPPAGDGPGSAGSMAPESTSSLSDLSGDAEGVWSIDIDQAFQEALAIYPPCGRRKIIISDEGKMYGRNELIARYIKLRCGKTRTRKQVSSHIQVLARKKLRDEQAKKKVPFHLNTGDIPSLLQQASPPGGVKSPSAVVFPPVSAAVAAITEISPQSSYSSIVPKVETDQISQQLFKSLPLWSFQQTPGLPIGMDLSQLVFQQSSPDKTVSPVKSEVVEETKPIASSQLTLHSFSAYVKCNKTSLRTELVKIENTLEKDDIDISVFYEKYPKLLRELFEKSEKKDVFFLAKCWANINVSDDVQNCQYAVDSFYSSREKFQLKVSTMACSFGNQAVEKIEQYFPIEFDGSYSFILNNSPMCDYMVKFIAELKKLNVIETMNNVLENFTVLQIVTNSETDELLMVLCFVFEVSQEPEPSCSVYRLIDGGGDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3J8</accession>
    <name>A0A2C9C3J8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C18C4.7</name>
        <name evidence="2" type="ORF">CELE_C18C4.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343823.1">
        <property type="nucleotide sequence ID" value="NM_001356645.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3J8"/>
    <dbReference type="SMR" id="A0A2C9C3J8"/>
    <dbReference type="GeneID" id="178941"/>
    <dbReference type="AGR" id="WB:WBGene00015968"/>
    <dbReference type="CTD" id="178941"/>
    <dbReference type="WormBase" id="C18C4.7c">
        <property type="protein sequence ID" value="CE52304"/>
        <property type="gene ID" value="WBGene00015968"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5832686at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015968">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3J8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="898"/>
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        </location>
    </feature>
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        <location>
            <begin position="909"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="SOF58821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C18C4.7c"/>
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    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
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            <fullName evidence="1">Isoform b of Zinc finger protein syd-9</fullName>
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        <name evidence="7" type="primary">syd-9</name>
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            <taxon>Ecdysozoa</taxon>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="10450" last="10455">
            <title>The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission.</title>
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                <person name="Wang Y."/>
                <person name="Gracheva E.O."/>
                <person name="Richmond J."/>
                <person name="Kawano T."/>
                <person name="Couto J.M."/>
                <person name="Calarco J.A."/>
                <person name="Vijayaratnam V."/>
                <person name="Jin Y."/>
                <person name="Zhen M."/>
            </authorList>
            <dbReference type="PubMed" id="16803962"/>
            <dbReference type="DOI" id="10.1073/pnas.0602073103"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A5E4M3Q4-3</id>
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            <sequence type="described" ref="VSP_061150"/>
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    </dbReference>
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    <evidence type="ECO:0000312" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK867.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK867.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZK867.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="ZK867.1f"/>
        </source>
    </evidence>
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<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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    <gene>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="10450" last="10455">
            <title>The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission.</title>
            <authorList>
                <person name="Wang Y."/>
                <person name="Gracheva E.O."/>
                <person name="Richmond J."/>
                <person name="Kawano T."/>
                <person name="Couto J.M."/>
                <person name="Calarco J.A."/>
                <person name="Vijayaratnam V."/>
                <person name="Jin Y."/>
                <person name="Zhen M."/>
            </authorList>
            <dbReference type="PubMed" id="16803962"/>
            <dbReference type="DOI" id="10.1073/pnas.0602073103"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A5E4M3Q4-3</id>
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        <isoform>
            <id>A0A5E4M3Q4-2</id>
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            <sequence type="described" ref="VSP_061149 VSP_061151"/>
        </isoform>
        <isoform>
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        </isoform>
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            <sequence type="described" ref="VSP_061151"/>
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    </comment>
    <dbReference type="RefSeq" id="NP_509214.2">
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    </dbReference>
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        <property type="gene ID" value="WBGene00044068"/>
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    </dbReference>
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    <evidence type="ECO:0000312" key="2">
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            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000312" key="5">
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="ZK867.1f"/>
        </source>
    </evidence>
    <sequence length="537" mass="58440" checksum="C6F91F01D37C4B77" modified="2019-11-13" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5E4M3Q4-4</accession>
    <name>SYD9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform d of Zinc finger protein syd-9</fullName>
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            <fullName evidence="7">Synapse defective protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">syd-9</name>
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        <name evidence="7" type="synonym">ztf-10</name>
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    <organism>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="10450" last="10455">
            <title>The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission.</title>
            <authorList>
                <person name="Wang Y."/>
                <person name="Gracheva E.O."/>
                <person name="Richmond J."/>
                <person name="Kawano T."/>
                <person name="Couto J.M."/>
                <person name="Calarco J.A."/>
                <person name="Vijayaratnam V."/>
                <person name="Jin Y."/>
                <person name="Zhen M."/>
            </authorList>
            <dbReference type="PubMed" id="16803962"/>
            <dbReference type="DOI" id="10.1073/pnas.0602073103"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
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        <isoform>
            <id>A0A5E4M3Q4-1</id>
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            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A5E4M3Q4-4</id>
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            <sequence type="described" ref="VSP_061151"/>
        </isoform>
        <isoform>
            <id>A0A5E4M3Q4-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_061149 VSP_061151"/>
        </isoform>
        <isoform>
            <id>A0A5E4M3Q4-5</id>
            <name evidence="6">e</name>
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        </isoform>
        <isoform>
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            <sequence type="described" ref="VSP_061150"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_509213.1">
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    </dbReference>
    <dbReference type="WormBase" id="ZK867.1d">
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        <property type="gene ID" value="WBGene00044068"/>
        <property type="gene designation" value="syd-9"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK867.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK867.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK867.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZK867.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="ZK867.1f"/>
        </source>
    </evidence>
    <sequence length="452" mass="48611" checksum="65C722EC87DB3ADC" modified="2019-11-13" version="1">MSVCVSPLVQATILMTEESLTCPQCPKSFSSTKLLQQHQQMFHTDKSVLLSLKSTDAPVGMDRAFICETCGKAFRFRSNLAEHRSVHTALKPYVCKFCGKSSRLKGNLTKHILKHHKKEQNEAIAKDDIIVKKAPKIVTKDNGPTTNGSTPTTSTATPSVITVSSALASSNGHNNNNNNHAVNNNLRTIKMELEDPDYNLIAKSAPTPVVSKIVATHTVTPRSRPTPKDIKEILETIAPSVGVSETPEEMCLLPKDASSESDRSVLISLGFDFGSTLSLNHQQLQQVVRELKGELSISPDTVQSDHSDDFEQDSPPPMAIANISTVGGEATLAAMIVAATNASGQRGDGTPDSTDTQKGCSPQRELSPESDPSTSSGDSCPSPPKMLHCKECGTLVRKSSHLPIHMTMSHGYPPPLVAAPVEEKPAPEQPVNASSLHNELRVISNAICTNVY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5E4M3Q4-5</accession>
    <name>SYD9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform e of Zinc finger protein syd-9</fullName>
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        <alternativeName>
            <fullName evidence="7">Synapse defective protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">syd-9</name>
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        <name evidence="7" type="synonym">ztf-10</name>
        <name evidence="7" type="ORF">ZK867.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="10450" last="10455">
            <title>The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission.</title>
            <authorList>
                <person name="Wang Y."/>
                <person name="Gracheva E.O."/>
                <person name="Richmond J."/>
                <person name="Kawano T."/>
                <person name="Couto J.M."/>
                <person name="Calarco J.A."/>
                <person name="Vijayaratnam V."/>
                <person name="Jin Y."/>
                <person name="Zhen M."/>
            </authorList>
            <dbReference type="PubMed" id="16803962"/>
            <dbReference type="DOI" id="10.1073/pnas.0602073103"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A5E4M3Q4-5</id>
            <name evidence="6">e</name>
            <sequence type="described" ref="VSP_061151 VSP_061150"/>
        </isoform>
        <isoform>
            <id>A0A5E4M3Q4-4</id>
            <name evidence="5">d</name>
            <sequence type="described" ref="VSP_061151"/>
        </isoform>
        <isoform>
            <id>A0A5E4M3Q4-1</id>
            <name evidence="7">f</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A5E4M3Q4-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_061151 VSP_061149"/>
        </isoform>
        <isoform>
            <id>A0A5E4M3Q4-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_061150"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001362161.1">
        <property type="nucleotide sequence ID" value="NM_001375061.2"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK867.1e">
        <property type="protein sequence ID" value="CE28199"/>
        <property type="gene ID" value="WBGene00044068"/>
        <property type="gene designation" value="syd-9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK867.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK867.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="ZK867.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="ZK867.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="ZK867.1f"/>
        </source>
    </evidence>
    <sequence length="435" mass="46840" checksum="07B7BB9E6C5714C4" modified="2019-11-13" version="1">MSVCVSPLVQATILMTEESLTCPQCPKSFSSTKLLQQHQQMFHTDKAFICETCGKAFRFRSNLAEHRSVHTALKPYVCKFCGKSSRLKGNLTKHILKHHKKEQNEAIAKDDIIVKKAPKIVTKDNGPTTNGSTPTTSTATPSVITVSSALASSNGHNNNNNNHAVNNNLRTIKMELEDPDYNLIAKSAPTPVVSKIVATHTVTPRSRPTPKDIKEILETIAPSVGVSETPEEMCLLPKDASSESDRSVLISLGFDFGSTLSLNHQQLQQVVRELKGELSISPDTVQSDHSDDFEQDSPPPMAIANISTVGGEATLAAMIVAATNASGQRGDGTPDSTDTQKGCSPQRELSPESDPSTSSGDSCPSPPKMLHCKECGTLVRKSSHLPIHMTMSHGYPPPLVAAPVEEKPAPEQPVNASSLHNELRVISNAICTNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7R9XNE4</accession>
    <name>A0A7R9XNE4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sulfite oxidase</fullName>
            <ecNumber evidence="6">1.8.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">suox-1</name>
        <name evidence="15" type="ORF">CELE_H13N06.4</name>
        <name evidence="17" type="ORF">H13N06.4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Energy metabolism; sulfur metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.1" evidence="6"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAD8145109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379385.1">
        <property type="nucleotide sequence ID" value="NM_001392900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7R9XNE4"/>
    <dbReference type="SMR" id="A0A7R9XNE4"/>
    <dbReference type="GeneID" id="181638"/>
    <dbReference type="AGR" id="WB:WBGene00010397"/>
    <dbReference type="CTD" id="181638"/>
    <dbReference type="WormBase" id="H13N06.4c">
        <property type="protein sequence ID" value="CE54309"/>
        <property type="gene ID" value="WBGene00010397"/>
        <property type="gene designation" value="suox-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="UniPathway" id="UPA00096"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02111">
        <property type="entry name" value="eukary_SO_Moco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000006">
        <property type="entry name" value="SUlfite OXidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 13" id="KW-0349">Heme</keyword>
    <keyword evidence="11 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAD8145109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="H13N06.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="A0A7R9XNE4"/>
        </source>
    </evidence>
    <sequence length="495" mass="55813" checksum="CAE2B5B5CAC62C83" modified="2021-06-02" version="1">MLGRGTSFNRFFRHRRQFNKLSGATSEHQRTNENHSYYKYAYIGGAATAGVLGFKHFVKTAKLDHAKDETMSEKKLENLQIYKQEEVKKHGKDADRIWVTYKDGVYDVTDFIAMHPGGDKILLAAGAAVDPFWALYSQHKTKEVLEILEGYRIGKLDVKDVPKIDFEDLSNIKTENHRLTVETIKGKTVDLSVEELKKKYKSYTIGSVIQCAGNRRADMNQYKKVQGLMWEGTAISNAEWTGVRLRDLLADAGIDVFDDKIKHVHFEGADVDPTGTPYGASIPIEKARGDEVIVAYHMNGVDIPRDHGAPLRVIVPGNVGARQVKWLRKIIVSEKESDSHWQQKDYRAFSPAVNIGDELKWNTVPSIQEYPVQCAICSPAPNTKVDRGDETVDISGYAWSGGGRGIIRIEVSVDGGETWNSVEMEQEEKQDQEHMYAWTLFKAEVKIPPGVKEFNIIAKAVDRAYNTQPETASGIWNVRGLIHNAWHRVPIIVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I609</accession>
    <name>A0A8D9I609_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitoferrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">mfn-1</name>
        <name evidence="17" type="ORF">CELE_W02B12.9</name>
        <name evidence="19" type="ORF">W02B12.9</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAG8860241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001391079.1">
        <property type="nucleotide sequence ID" value="NM_001404239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9I609"/>
    <dbReference type="SMR" id="A0A8D9I609"/>
    <dbReference type="GeneID" id="174752"/>
    <dbReference type="AGR" id="WB:WBGene00012204"/>
    <dbReference type="CTD" id="174752"/>
    <dbReference type="WormBase" id="W02B12.9b">
        <property type="protein sequence ID" value="CE54348"/>
        <property type="gene ID" value="WBGene00012204"/>
        <property type="gene designation" value="mfn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000127">
        <property type="entry name" value="MC family mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000054">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF20">
        <property type="entry name" value="MITOFERRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="112"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="203"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG8860241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="W02B12.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8D9I609"/>
        </source>
    </evidence>
    <sequence length="316" mass="34578" checksum="26E058AD0A8CEE8F" modified="2022-01-19" version="1">MGGGGEDEYESLPTHSVPVHLTAGALAGAVEHCVMFPFDSVKTRMQSLCPCPETKCPTPVHSLMSIVKREGWLRPLRGVNAVAAGSMPAHALYFTVYEKMKGYLTGNSAGHSNTLAYGASGVVATLIHDAIMNPAEVVKQRMQMAFSPYGSSLECARCVYNREGVAAFYRSYTTQLAMNVPFQAIHFMSYEFWQHVLNPEHKYDPKSHLIAGGLAGGLAAALTTPMDCVKTVLNTQQAAEADPANRRIFLQNELQARYRYRGISDAVRTIYSQRGLSGFSCGLQARVIFQVPATALSWSVYELFKFMLSFEGGHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I610</accession>
    <name>A0A8D9I610_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitoferrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">mfn-1</name>
        <name evidence="17" type="ORF">CELE_W02B12.9</name>
        <name evidence="19" type="ORF">W02B12.9</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAG8860242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001391080.1">
        <property type="nucleotide sequence ID" value="NM_001404240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9I610"/>
    <dbReference type="SMR" id="A0A8D9I610"/>
    <dbReference type="GeneID" id="174752"/>
    <dbReference type="AGR" id="WB:WBGene00012204"/>
    <dbReference type="CTD" id="174752"/>
    <dbReference type="WormBase" id="W02B12.9c">
        <property type="protein sequence ID" value="CE54388"/>
        <property type="gene ID" value="WBGene00012204"/>
        <property type="gene designation" value="mfn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000127">
        <property type="entry name" value="MC family mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000054">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF20">
        <property type="entry name" value="MITOFERRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="114"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="205"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG8860242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="W02B12.9c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8D9I610"/>
        </source>
    </evidence>
    <sequence length="314" mass="34334" checksum="CE420C499AEC7914" modified="2022-01-19" version="1">MGGGGEDEYESLPTHSVPIQVHLTAGALAGAVEHCVMFPFDSVKTRMQSLCPCPETKCPTPVHSLMSIVKREGWLRPLRGVNAVAAGSMPAHALYFTVYEKMKGYLTGNSAGHSNTLAYGASGVVATLIHDAIMNPAEVVKQRMQMAFSPYGSSLECARCVYNREGVAAFYRSYTTQLAMNVPFQAIHFMSYEFWQHVLNPEHKYDPKSHLIAGGLAGGLAAALTTPMDCVKTVLNTQQAAEADPANRRIFLQARYRYRGISDAVRTIYSQRGLSGFSCGLQARVIFQVPATALSWSVYELFKFMLSFEGGHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I618</accession>
    <name>A0A8D9I618_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DSPc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_W09H1.1</name>
        <name evidence="3 5" type="ORF">W09H1.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAG8860244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9I618"/>
    <dbReference type="SMR" id="A0A8D9I618"/>
    <dbReference type="AGR" id="WB:WBGene00012372"/>
    <dbReference type="WormBase" id="W09H1.1c">
        <property type="protein sequence ID" value="CE54355"/>
        <property type="gene ID" value="WBGene00012372"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF529">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG8860244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W09H1.1c"/>
        </source>
    </evidence>
    <sequence length="378" mass="42043" checksum="91A293AB7D776C8E" modified="2022-01-19" version="1">MKGSSKSATYQSPNAKPLTVRARAGSTPGLDSKQIHSLINKNNTFNRILCKNADTVDSPTPTPSLTASRSSSVISIASTVSTETVVSSGRLIKVAPAKQDTFSILSDECDVTETPRTPVSLSNVEIFDSDNDYPGTGLSPKSPPFSEGSEDVFERVKTAKVPTTPVKASVTNPFRSLYIDEVVWQIDDVVFASAIDAVNNNSLMCRLNIEFICEIADETADHVQEARRQNRGFECPCFCNRSSSHFRYYLSYSLPETEQRCMMLTEDTKLNDMFDGFLDLVQRARRAKRNVLVCSTRGRNRAPAFASAYLMSKEQIPRQAAVAKVRTAMGTMRPPVNISDFMQRKLMRYQQHLGIDLSNAYDPTHTLPLFHVKRSAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I620</accession>
    <name>A0A8D9I620_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T26A5.2</name>
        <name evidence="2 4" type="ORF">T26A5.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAG8860256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9I620"/>
    <dbReference type="AGR" id="WB:WBGene00020819"/>
    <dbReference type="WormBase" id="T26A5.2h">
        <property type="protein sequence ID" value="CE54358"/>
        <property type="gene ID" value="WBGene00020819"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5833282at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG8860256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T26A5.2h"/>
        </source>
    </evidence>
    <sequence length="841" mass="96658" checksum="32363E0514C3D50E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I621</accession>
    <name>A0A8D9I621_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ligand-Gated ion Channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">acc-4</name>
        <name evidence="17" type="ORF">CELE_T27E9.9</name>
        <name evidence="19" type="ORF">T27E9.9</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAG8860257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001407497.1">
        <property type="nucleotide sequence ID" value="NM_001420560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8D9I621"/>
    <dbReference type="SMR" id="A0A8D9I621"/>
    <dbReference type="GeneID" id="176778"/>
    <dbReference type="AGR" id="WB:WBGene00012099"/>
    <dbReference type="CTD" id="176778"/>
    <dbReference type="WormBase" id="T27E9.9b">
        <property type="protein sequence ID" value="CE54378"/>
        <property type="gene ID" value="WBGene00012099"/>
        <property type="gene designation" value="acc-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000035">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034461258" evidence="14">
        <location>
            <begin position="18"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="54"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="268"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG8860257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="T27E9.9b"/>
        </source>
    </evidence>
    <sequence length="409" mass="46438" checksum="AA51A2C61B34A470" modified="2022-01-19" version="1">MRLIILVISILISNAGSLLRSLEDDSNECMFNCPKRARNVSVPHTEKTCMGDDAIIAQILDGYNKLDLPGGGHVVVSIEIWVQEVSKIIEITSEFELDIYVTERWTDPSLAYSHLNPCKSNMSVDGATILNKIWNPHACFVNSKLANIHESPFKNIFLQIYSNGSIWHNYRIKLTGPCSSTLRTFPIDQQRCMLFYESFTHNTDQVKMEWITTVPPITILKGNITLPDYVLVDFSSSSELRLYPPGIFNELIATFTFQRLYGFYILQVYVPAYISVFISWVSFTLGAEQIPSRTTVGVNSLLALTFQFGAVVNNLPKTSDVKAIDVWILSSMAFIFASLIELAVVGYLSRDGQHGSIKCRCSWLCMNCKDWTALKIDQMSSIVFPVSFLAFNIWYWFIFLGKVTRMNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-10-02" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A7UQ07</accession>
    <name>A7UQ07_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">best-22</name>
        <name evidence="8" type="ORF">CELE_ZC518.1</name>
        <name evidence="10" type="ORF">ZC518.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAO94909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122833.1">
        <property type="nucleotide sequence ID" value="NM_001129361.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7UQ07"/>
    <dbReference type="SMR" id="A7UQ07"/>
    <dbReference type="PeptideAtlas" id="A7UQ07"/>
    <dbReference type="GeneID" id="191197"/>
    <dbReference type="UCSC" id="ZC518.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013921"/>
    <dbReference type="CTD" id="191197"/>
    <dbReference type="WormBase" id="ZC518.1c">
        <property type="protein sequence ID" value="CE41529"/>
        <property type="gene ID" value="WBGene00013921"/>
        <property type="gene designation" value="best-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013921">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A7UQ07">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF20">
        <property type="entry name" value="BESTROPHIN HOMOLOG 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAO94909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="ZC518.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A7UQ07"/>
        </source>
    </evidence>
    <sequence length="483" mass="55306" checksum="61A9AA79993308BE" modified="2007-10-02" version="1">MTISYTLDVSQTNLQSFFSLLLRWRGSVWKAVFGQLAVWTAVFLLISCIYRYMLSPSQQDVFEQLIRYFDNKLDANIPLTFLLGFFVSFVVARWGSILNGIGWIDDASLLFATYIRGADEETRVIRRNLVRYLVLSQALVLRDISMQVRKRFPTMDTLAASGLMTHEEMDILDHIKDPYSRYWTSIQWSLNLVYECQKKGKVDSYYLMNKIVDEIGKFRHGLASLLKYDWVPVPLVYPQVIFLAVRIYFMICLIGRQFIVTGPNPSGIDLWLPITTMVQFLVYMGWMKVAEALLNPLGEDDDDLECNYIIDKNLITGLSIVDTMWKHDDTGYSMVEEHMAKTPAQKKDEFWGIDKIAPLYSMESAERSVHPLVGSASKINLVKNKKEIVMTPHKNKLSELDPSEQKTYLRRVNVSDHNAKHAKQRGLERANSPDKCLSKMRSRSNGKFRTSANGSQNGVDLWTRADSPDDSSHDSCSHSGSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-10-02" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>A7UQ08</accession>
    <name>A7UQ08_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">kvs-2</name>
        <name evidence="17" type="ORF">C32C4.1</name>
        <name evidence="15" type="ORF">CELE_C32C4.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAO94906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122871.1">
        <property type="nucleotide sequence ID" value="NM_001129399.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7UQ08"/>
    <dbReference type="SMR" id="A7UQ08"/>
    <dbReference type="GeneID" id="183120"/>
    <dbReference type="KEGG" id="cel:CELE_C32C4.1"/>
    <dbReference type="UCSC" id="C32C4.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007862"/>
    <dbReference type="CTD" id="183120"/>
    <dbReference type="WormBase" id="C32C4.1b">
        <property type="protein sequence ID" value="CE41505"/>
        <property type="gene ID" value="WBGene00007862"/>
        <property type="gene designation" value="kvs-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="PhylomeDB" id="A7UQ08"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007862">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A7UQ08">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000088">
        <property type="entry name" value="Protein CBG09661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000176">
        <property type="entry name" value="Protein CBG09661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF121">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="63"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAO94906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C32C4.1b"/>
        </source>
    </evidence>
    <sequence length="538" mass="61084" checksum="9C48B46A9F8830D6" modified="2007-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-10-02" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>A7UQ09</accession>
    <name>A7UQ09_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neurexin-3-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nrx-1</name>
        <name evidence="15" type="ORF">C29A12.4</name>
        <name evidence="13" type="ORF">CELE_C29A12.4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAO94905.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122868.2">
        <property type="nucleotide sequence ID" value="NM_001129396.5"/>
    </dbReference>
    <dbReference type="SMR" id="A7UQ09"/>
    <dbReference type="IntAct" id="A7UQ09">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="179503"/>
    <dbReference type="KEGG" id="cel:CELE_C29A12.4"/>
    <dbReference type="UCSC" id="C29A12.4">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007799"/>
    <dbReference type="CTD" id="42646"/>
    <dbReference type="WormBase" id="C29A12.4b">
        <property type="protein sequence ID" value="CE46888"/>
        <property type="gene ID" value="WBGene00007799"/>
        <property type="gene designation" value="nrx-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275838at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007799">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A7UQ09">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000015">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF89">
        <property type="entry name" value="NEUREXIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1600"/>
            <end position="1621"/>
        </location>
    </feature>
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        <location>
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        <location>
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        <source>
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            <dbReference type="PROSITE" id="PS50026"/>
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            <dbReference type="EMBL" id="CAO94905.2"/>
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        <source>
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        <source>
            <dbReference type="WormBase" id="C29A12.4b"/>
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    <sequence length="1716" mass="191720" checksum="A2FF2A0A6E43AB11" modified="2012-03-21" version="2"> </sequence>
</entry>
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    <accession>A7UQ11</accession>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="C36F7.4c"/>
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</entry>
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    <accession>A9D218</accession>
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            <fullName evidence="2">(Na+)-NQR maturation NqrM</fullName>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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    </feature>
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            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD73494.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y65B4BL.6b"/>
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    </evidence>
    <sequence length="42" mass="4056" checksum="0F83CE1A4502C606" modified="2008-02-05" version="1">MVVCFVLLAISTGESLACLGGSGGGCCMTSGCPNPCAGFGRK</sequence>
</entry>
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    <name>A9Z1J6_CAEEL</name>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        <text evidence="5">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily.</text>
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    <dbReference type="SMR" id="A9Z1J6"/>
    <dbReference type="PeptideAtlas" id="A9Z1J6"/>
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        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019301"/>
    <dbReference type="WormBase" id="K02D10.1c">
        <property type="protein sequence ID" value="CE42008"/>
        <property type="gene ID" value="WBGene00019301"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_0_1_1"/>
    <dbReference type="OMA" id="CETDIKF"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019301">
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        <property type="entry name" value="FI11325P-RELATED"/>
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        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PGP-type_phosphatase"/>
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        <property type="entry name" value="HAD-like"/>
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    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="21"/>
        </location>
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        <location>
            <position position="23"/>
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        <location>
            <position position="21"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        <location>
            <position position="23"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD71831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="K02D10.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A9Z1J6"/>
        </source>
    </evidence>
    <sequence length="299" mass="32865" checksum="88D770CC63EBECF6" modified="2008-02-05" version="1">MSINRISKNELLANYDTFLFDADGVLWTGDIPVPGAIEWINLLLEDPSKKVFVLTNNSTKTLEQYMKKIEKLGFGHLGRNNVISPAIVLADYLKSNADKFSGEYVYLIGTENLKATLENDGGVKCFGTGPDSIRDHTDGDFIHKVDMSIAPKAVVCSYDAHFSYPKIMKASNYLQDPSVEYLVTNQDYTFPGPVPGVVIPGSGATSAAVTAVTGRDPKVFGKPHKPMADFLLRRAHVDPKRTVMFGDRLDTDIMFGNANGFSSVWMPTGVHTIVDIHNAKEKGQLDRIPTFTHCFATGD</sequence>
</entry>
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        <name evidence="5 7" type="ORF">B0303.7</name>
        <name evidence="5" type="ORF">CELE_B0303.7</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
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    <reference key="2">
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                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="P67PHOX"/>
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            <end position="226"/>
        </location>
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            <end position="144"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD61717.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="B0303.7b"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A9Z1J8"/>
        </source>
    </evidence>
    <sequence length="467" mass="49859" checksum="E8C3A551DE05462A" modified="2008-02-05" version="1">MSKDTSTFSVSAAKALFESAKRPEVRNAAIAAAKNPFVRQTAKNVAQDEKARGAVLNAVKDPSGGNKISAAFAVADANRKSDSVPPPPPHRGGTSPGKLSGSHSAIRSQLENMHIGGSVMSSNSSTATPSYQSNSTSSYSSSAPVAPPPVPRHTQSIPSYSAPAISTPYGIAKFDYAPTQSDEMGLRIGDTVLISKKVDAEWFYGENQNQRTFGIVPSSYLDIKIPLKEAFTALPPRPAAPSGSSSGTYATAIYDYNSNEAGDLNFAVGSQIMVTARVNEEWLEGECFGRSGIFPSQFVDCPNLYQVPMKQSAPSSAPSYSHPITNNSGPKQTVTVSYDYDSGVASDLRLFEGDVITALEDIDAQWLLAECRGQQGMVPKTFLGPPYGSPKKAPSKGIAEIACAFSPKKAVATGDYHSEDPKHLYVTRGDHLLIVEDVDDYYYKGKLEAFKTLPAGILPKNIVKLEN</sequence>
</entry>
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    <accession>A9Z1K0</accession>
    <name>A9Z1K0_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
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        <name evidence="3 5" type="primary">rgs-5</name>
        <name evidence="5" type="ORF">B0336.4</name>
        <name evidence="3" type="ORF">CELE_B0336.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122672.1">
        <property type="nucleotide sequence ID" value="NM_001129200.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9Z1K0"/>
    <dbReference type="SMR" id="A9Z1K0"/>
    <dbReference type="PeptideAtlas" id="A9Z1K0"/>
    <dbReference type="GeneID" id="175794"/>
    <dbReference type="UCSC" id="B0336.4b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004348"/>
    <dbReference type="CTD" id="175794"/>
    <dbReference type="WormBase" id="B0336.4b">
        <property type="protein sequence ID" value="CE41974"/>
        <property type="gene ID" value="WBGene00004348"/>
        <property type="gene designation" value="rgs-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022662_1_0_1"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004348">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A9Z1K0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000041">
        <property type="entry name" value="Regulator of G-protein signaling rgs-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
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    </dbReference>
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        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="81"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="181"/>
            <end position="304"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
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        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD61535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="B0336.4b"/>
        </source>
    </evidence>
    <sequence length="459" mass="52280" checksum="65D46EDC3E90F8A5" modified="2008-02-05" version="1">MSSFLGRLRRKKDKEQNGHTATSSDGAYQNGNAHRDSLVNDHICIPAQRNSLTVAQQSADIGSGSDHEGIIVKQKPQLAFSLDRLLIDSSALSYFIQYLDSTDKLNLIKFWMHVEGFKSSFSEQIQAAQEYKLSASPLQKSCFDEAQDFVKSLFEYRYFDEFQNSVYYKKHELEVLSDGCSLADILKVQPLLLSFLEFIKEKEDHDTIQFLLGCDSFEANLDLMEDSEALGDAMALYEKYFSMQATNMIDLGSAIRAEMESLICEESGRPNRKAFRTAKTACFFRLHDKYLSDFLKTSYYHNYLGELQSFIDFTVELPRKVRNRAASSSDVASSTDSLTHAFSRHLEVLEKKMNDKDESTQTPTGSPSSSKRSTPRTPRSSRLAEVDEMGRYHALYDDSHSQTPQKPMRIKSTLRKYLDKNTLREEEIAEEVARTIIRDMQEMVASSAESPTSPTFRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-02-05" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>A9Z1K4</accession>
    <name>A9Z1K4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CYCLIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_T12C9.7</name>
        <name evidence="6 8" type="ORF">T12C9.7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD73614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122637.1">
        <property type="nucleotide sequence ID" value="NM_001129165.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A9Z1K4"/>
    <dbReference type="SMR" id="A9Z1K4"/>
    <dbReference type="GeneID" id="173782"/>
    <dbReference type="UCSC" id="T12C9.7b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020461"/>
    <dbReference type="CTD" id="173782"/>
    <dbReference type="WormBase" id="T12C9.7b">
        <property type="protein sequence ID" value="CE41931"/>
        <property type="gene ID" value="WBGene00020461"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020461">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A9Z1K4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000252">
        <property type="entry name" value="Protein CBG20098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000280">
        <property type="entry name" value="Protein CBG20098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="163"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="5">
        <location>
            <begin position="258"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD73614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="T12C9.7b"/>
        </source>
    </evidence>
    <sequence length="399" mass="45363" checksum="25236654DC9E917A" modified="2008-02-05" version="1">MLRRKSVNLKKEQSTETVLSNSQSPSFVDFKRITRSKKYSAAQKNAPDEKKQCTKKRQLPSLAPACEELQPKKSKVTEETVASQKTHGLSNLDDYCLEMPDFEKQMLSIWQSNIDITEMYRALCKSASLIPAPHTLFCVYEIPESPNKTQQFCPSSIEDRQRVLLNIFSRRFQLKVSSEALHLGAALLDKCLDMMSVNKASLDELAAVTLVIASKLEDVNCLTIENIIGVELIEKSAAQMAALERFVLTSLSFKITIPTPLHFSTYMLVYLSASPAKIHLTYYLLELSILYVHNRRFPSDVVANAATCLAFAIDSEPSVDQTPSTVLRETELRLRDFTGKNVKDEWDREREVMLTLIDLFLAGDENHDIYREYCTSRRNYVALRQSVPELLETLRKDST</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-07-05" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B7FAS0-2</accession>
    <name>MCD1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform b of Modifier of cell death</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mcd-1</name>
        <name evidence="3" type="ORF">Y51H1A.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2007" name="Genetics" volume="175" first="1719" last="1733">
            <title>DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Reddien P.W."/>
                <person name="Andersen E.C."/>
                <person name="Huang M.C."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="17237514"/>
            <dbReference type="DOI" id="10.1534/genetics.106.068148"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF HIS-277</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>B7FAS0-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_059021"/>
        </isoform>
        <isoform>
            <id>B7FAS0-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001254413.1">
        <property type="nucleotide sequence ID" value="NM_001267484.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y51H1A.6b">
        <property type="protein sequence ID" value="CE43386"/>
        <property type="gene ID" value="WBGene00013096"/>
        <property type="gene designation" value="mcd-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y51H1A.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y51H1A.6b"/>
        </source>
    </evidence>
    <sequence length="259" mass="29287" checksum="04348B1EA2DF2C21" modified="2009-02-10" version="1">MASYVVELVCQIDAEVKVRRNPALRIDDVKRDMIAGIAMQERVHQPERRPRRSAAPASPAKPQYRPQPPARSHEEYTQRIMNKVKEYMPRRRPDAYDLQQGQQQSRLQMLREQTLLRAPLEEEKPPVATMAPVPDEHKAIPWTRPGRKRAMGPGEAATAPAKRRGRPTKKEEAAEAAAKLIQAENEMVVEEEEVEEPPVVEQEQVPKEKEVEVAEAEKLPEQVKTEPSVTPSSAPPTPATTATKTRTGRVVKPKKWDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>D3KFU4</accession>
    <name>D3KFU4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sideroflexin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">sfxn-1.4</name>
        <name evidence="12" type="ORF">C47D12.3</name>
        <name evidence="10" type="ORF">CELE_C47D12.3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CBJ25063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379510.1">
        <property type="nucleotide sequence ID" value="NM_001393201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3KFU4"/>
    <dbReference type="GeneID" id="183547"/>
    <dbReference type="AGR" id="WB:WBGene00008137"/>
    <dbReference type="CTD" id="183547"/>
    <dbReference type="WormBase" id="C47D12.3b">
        <property type="protein sequence ID" value="CE44447"/>
        <property type="gene ID" value="WBGene00008137"/>
        <property type="gene designation" value="sfxn-1.4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039425_1_0_1"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008137">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3KFU4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF35">
        <property type="entry name" value="SIDOREFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBJ25063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C47D12.3b"/>
        </source>
    </evidence>
    <sequence length="156" mass="16963" checksum="1CA02BDBF6AAF670" modified="2010-03-23" version="1">MLKKWKNAPPILARLVPFAAIAFANAINIPMMRNKEFTNGIPVEDGEGRTMGFSTVAPGHAIPQVVLSRVGMAVPNMVLGPVILEQLSKTAWYTPGMAAPLQTLLCGFMLAFSTPICCALFPQKSSIQVDKLELSLQDHINKLANPPKVVYYNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D3KFV0</accession>
    <name>D3KFV0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_K08D8.12</name>
        <name evidence="3 5" type="ORF">K08D8.12</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBJ25087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255681.1">
        <property type="nucleotide sequence ID" value="NM_001268752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3KFV0"/>
    <dbReference type="SMR" id="D3KFV0"/>
    <dbReference type="GeneID" id="13198723"/>
    <dbReference type="KEGG" id="cel:CELE_K08D8.12"/>
    <dbReference type="AGR" id="WB:WBGene00194926"/>
    <dbReference type="CTD" id="13198723"/>
    <dbReference type="WormBase" id="K08D8.12b">
        <property type="protein sequence ID" value="CE44451"/>
        <property type="gene ID" value="WBGene00194926"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2499945_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00194926">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3KFV0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBJ25087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K08D8.12b"/>
        </source>
    </evidence>
    <sequence length="86" mass="9529" checksum="024CFB2C56308AC6" modified="2010-03-23" version="1">MEPQAPNTYQYPTTSHFEAPPAYSDSTNNVYPPTQVAGEPAVIVVVPQNQFPQPRVHCFQRCIVLTVIMIIILGSVGTTLYLLLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D3KFV4</accession>
    <name>D3KFV4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_M04B2.7</name>
        <name evidence="2 4" type="ORF">M04B2.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBJ25092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3KFV4"/>
    <dbReference type="AGR" id="WB:WBGene00010849"/>
    <dbReference type="WormBase" id="M04B2.7b">
        <property type="protein sequence ID" value="CE44537"/>
        <property type="gene ID" value="WBGene00010849"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1497567_0_0_1"/>
    <dbReference type="OrthoDB" id="5788478at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010849">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3KFV4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBJ25092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="M04B2.7b"/>
        </source>
    </evidence>
    <sequence length="180" mass="20656" checksum="5D4C223DC378FA75" modified="2010-03-23" version="1">MAFTYQNSLISQLPIRPAPNSFRDPSSYNTDHQFSTHIYDYSLIALLPVILVGLLITTIFCVYRFRRWKHNKKQLAELNAFYEIVESSPCLASGKPYLIQHCKDVEKSECDRITRAVCVPTQSSIFFQPIPPKAKSVRCNSDVLKAVNASEVLFHFAQLPTIEKINNNNNKKSLHFIHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D3KFV5</accession>
    <name>D3KFV5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_M04B2.7</name>
        <name evidence="2 4" type="ORF">M04B2.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBJ25093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255565.1">
        <property type="nucleotide sequence ID" value="NM_001268636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3KFV5"/>
    <dbReference type="GeneID" id="3565562"/>
    <dbReference type="AGR" id="WB:WBGene00010849"/>
    <dbReference type="CTD" id="3565562"/>
    <dbReference type="WormBase" id="M04B2.7c">
        <property type="protein sequence ID" value="CE34943"/>
        <property type="gene ID" value="WBGene00010849"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115550_0_0_1"/>
    <dbReference type="OrthoDB" id="5788478at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010849">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3KFV5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBJ25093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="M04B2.7c"/>
        </source>
    </evidence>
    <sequence length="168" mass="19349" checksum="99C17FFF45B26172" modified="2010-03-23" version="1">MDFFDVRKFQSSHRDFVVNDGRLHVVSDYSLIALLPVILVGLLITTIFCVYRFRRWKHNKKQLAELNAFYEIVESSPCLASGKPYLIQHCKDVEKSECDRITRAVCVPTQSSIFFQPIPPKAKSVRCNSDVLKAVNASEVLFHFAQLPTIEKINNNNNKKSLHFIHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>D3KFV9</accession>
    <name>D3KFV9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">clec-199</name>
        <name evidence="9" type="ORF">C30H6.1</name>
        <name evidence="7" type="ORF">CELE_C30H6.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBJ25058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255943.1">
        <property type="nucleotide sequence ID" value="NM_001269014.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3KFV9"/>
    <dbReference type="SMR" id="D3KFV9"/>
    <dbReference type="GeneID" id="183064"/>
    <dbReference type="AGR" id="WB:WBGene00007820"/>
    <dbReference type="CTD" id="183064"/>
    <dbReference type="WormBase" id="C30H6.1d">
        <property type="protein sequence ID" value="CE44510"/>
        <property type="gene ID" value="WBGene00007820"/>
        <property type="gene designation" value="clec-199"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863877at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007820">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3KFV9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052309">
        <property type="entry name" value="C-type_Lectin_Domain_Fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490:SF6">
        <property type="entry name" value="ASIALOGLYCOPROTEIN RECEPTOR 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003047170" evidence="5">
        <location>
            <begin position="21"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="108"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBJ25058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C30H6.1d"/>
        </source>
    </evidence>
    <sequence length="653" mass="70400" checksum="3FDA50FFD5EB1D38" modified="2010-03-23" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D3KFW2</accession>
    <name>D3KFW2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_M02G9.4</name>
        <name evidence="1 3" type="ORF">M02G9.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CBJ25090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254243.1">
        <property type="nucleotide sequence ID" value="NM_001267314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3KFW2"/>
    <dbReference type="GeneID" id="13186765"/>
    <dbReference type="AGR" id="WB:WBGene00194935"/>
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        <property type="gene ID" value="WBGene00194935"/>
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        <property type="component" value="Chromosome II"/>
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</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <strain evidence="16 17">Bristol N2</strain>
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            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
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            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
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    <dbReference type="AGR" id="WB:WBGene00002192"/>
    <dbReference type="CTD" id="178068"/>
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        <property type="protein sequence ID" value="CE44446"/>
        <property type="gene ID" value="WBGene00002192"/>
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    <dbReference type="PANTHER" id="PTHR24356:SF414">
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    </dbReference>
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    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
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            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="88"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
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    <feature type="region of interest" description="Disordered" evidence="13">
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    <feature type="region of interest" description="Disordered" evidence="13">
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    <feature type="region of interest" description="Disordered" evidence="13">
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="1346"/>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="73"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <end position="158"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <sequence length="1382" mass="150626" checksum="7750AFF1E36E5C42" modified="2010-03-23" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D3KFX1</accession>
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        <name evidence="2 4" type="ORF">Y65A5A.2</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
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    <dbReference type="SMR" id="D3KFX1"/>
    <dbReference type="PeptideAtlas" id="D3KFX1"/>
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    <dbReference type="AGR" id="WB:WBGene00013419"/>
    <dbReference type="CTD" id="190478"/>
    <dbReference type="WormBase" id="Y65A5A.2b">
        <property type="protein sequence ID" value="CE44464"/>
        <property type="gene ID" value="WBGene00013419"/>
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    <dbReference type="HOGENOM" id="CLU_687420_0_0_1"/>
    <dbReference type="OrthoDB" id="5877695at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
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    <dbReference type="Bgee" id="WBGene00013419">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3KFX1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBJ25114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y65A5A.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="D3KFX1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12904" checksum="CB6AD32C40F1D5F1" modified="2010-03-23" version="1">MPTPLTHWSRWMQTASRFVDEYPNFSVLVISVLFAMLLFLICLVIAECVKSRRHHHRSVPRHHIPKSVTADLYNTSNCSHFYTKPTILLNQQEVTMQLITSDITVDCSSETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>G3DRG2</accession>
    <accession>H2KMM1</accession>
    <name>G3DRG2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIR domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Y71A12B.17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">gadr-5</name>
        <name evidence="3" type="ORF">CELE_Y71A12B.17</name>
        <name evidence="5" type="ORF">Y71A12B.17</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2011" name="PLoS Biol." volume="9" first="E1001115" last="E1001115">
            <title>A Novel Sperm-Delivered Toxin Causes Late-Stage Embryo Lethality and Transmission Ratio Distortion in C. elegans.</title>
            <authorList>
                <person name="Seidel H.S."/>
                <person name="Ailion M."/>
                <person name="Li J."/>
                <person name="van Oudenaarden A."/>
                <person name="Rockman M.V."/>
                <person name="Kruglyak L."/>
            </authorList>
            <dbReference type="PubMed" id="21814493"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.1001115"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HQ291557">
        <property type="protein sequence ID" value="AEN71566.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCE71291.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001252264.2">
        <property type="nucleotide sequence ID" value="NM_001265335.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3DRG2"/>
    <dbReference type="SMR" id="G3DRG2"/>
    <dbReference type="STRING" id="6239.Y71A12B.17b.1"/>
    <dbReference type="PaxDb" id="6239-Y71A12B.17b"/>
    <dbReference type="GeneID" id="4927064"/>
    <dbReference type="KEGG" id="cel:CELE_Y71A12B.17"/>
    <dbReference type="AGR" id="WB:WBGene00045058"/>
    <dbReference type="CTD" id="4927064"/>
    <dbReference type="WormBase" id="Y71A12B.17b">
        <property type="protein sequence ID" value="CE48003"/>
        <property type="gene ID" value="WBGene00045058"/>
        <property type="gene designation" value="gadr-5"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5838776at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00045058">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G3DRG2">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001202">
        <property type="entry name" value="Gastrulation-defective protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF28">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEN71566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCE71291.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y71A12B.17b"/>
        </source>
    </evidence>
    <sequence length="915" mass="104201" checksum="6E4871AD30B4AA4F" modified="2011-11-16" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-09-16" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>G5EBZ8-2</accession>
    <name>ARK1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Ack-related non-receptor tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ras-regulating kinase ark-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ark-1</name>
        <name evidence="6" type="ORF">C01C7.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2000" name="Mol. Cell" volume="6" first="65" last="75">
            <title>ARK-1 inhibits EGFR signaling in C. elegans.</title>
            <authorList>
                <person name="Hopper N.A."/>
                <person name="Lee J."/>
                <person name="Sternberg P.W."/>
            </authorList>
            <dbReference type="PubMed" id="10949028"/>
            <dbReference type="DOI" id="10.1016/S1097-2765(00)00008-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2003" name="Science" volume="302" first="1779" last="1782">
            <title>Redox regulation of germline and vulval development in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Shibata Y."/>
                <person name="Branicky R."/>
                <person name="Landaverde I.O."/>
                <person name="Hekimi S."/>
            </authorList>
            <dbReference type="PubMed" id="14657502"/>
            <dbReference type="DOI" id="10.1126/science.1087167"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EBZ8-1</id>
            <name evidence="6">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EBZ8-2</id>
            <name evidence="7">b</name>
            <sequence type="described" ref="VSP_057849"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001255653.1">
        <property type="nucleotide sequence ID" value="NM_001268724.2"/>
    </dbReference>
    <dbReference type="WormBase" id="C01C7.1b">
        <property type="protein sequence ID" value="CE43742"/>
        <property type="gene ID" value="WBGene00000186"/>
        <property type="gene designation" value="ark-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q07912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="10949028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAB65957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C01C7.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C01C7.1b"/>
        </source>
    </evidence>
    <sequence length="1039" mass="114876" checksum="3CBA24D55567BE39" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-10-16" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>G5ECT0-2</accession>
    <name>PBO5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform a of Proton-gated ion channel subunit pbo-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PBoc defective protein pbo-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">pbo-5</name>
        <name evidence="5" type="synonym">lgc-2</name>
        <name type="ORF">Y44A6E.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2008" name="Cell" volume="132" first="149" last="160">
            <title>Protons act as a transmitter for muscle contraction in C. elegans.</title>
            <authorList>
                <person name="Beg A.A."/>
                <person name="Ernstrom G.G."/>
                <person name="Nix P."/>
                <person name="Davis M.W."/>
                <person name="Jorgensen E.M."/>
            </authorList>
            <dbReference type="PubMed" id="18191228"/>
            <dbReference type="DOI" id="10.1016/j.cell.2007.10.058"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-186; HIS-189; THR-309; LEU-321; PRO-330 AND MET-347</scope>
        <source>
            <strain evidence="1">Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="PLoS ONE" volume="10" first="E0124515" last="E0124515">
            <title>Aberrant fat metabolism in Caenorhabditis elegans mutants with defects in the defecation motor program.</title>
            <authorList>
                <person name="Sheng M."/>
                <person name="Hosseinzadeh A."/>
                <person name="Muralidharan S.V."/>
                <person name="Gaur R."/>
                <person name="Selstam E."/>
                <person name="Tuck S."/>
            </authorList>
            <dbReference type="PubMed" id="25849533"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0124515"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5ECT0-2</id>
            <name evidence="1 2">a</name>
            <sequence type="described" ref="VSP_053336"/>
        </isoform>
        <isoform>
            <id>G5ECT0-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024239.1">
        <property type="nucleotide sequence ID" value="NM_001029068.5"/>
    </dbReference>
    <dbReference type="WormBase" id="Y44A6E.1a">
        <property type="protein sequence ID" value="CE32021"/>
        <property type="gene ID" value="WBGene00012857"/>
        <property type="gene designation" value="pbo-5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18191228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="18191228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="CAH19091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y44A6E.1b"/>
        </source>
    </evidence>
    <sequence length="504" mass="57857" checksum="3C9FD10E5465D5DA" modified="2011-12-14" version="1" precursor="true">MTRLSILQHLLTFLILSKINATSTTESYFDSSEEAPNVLLNHLNNESEGEELTQINDTQPAFVPGSSKRLTEYLLSRHNLNAPPDGLLYVEYELELVHILGIDELKQTMTVLIYVDEHWVDPSLTWDPALFGGITKTWIPLDKIWVPDIIVFNMLAHEDLLSAVRAPARIHYNGTIVASHPAVHTVSCEINIRHFPLDDQRCAIEIASWAYGQEKIRLHAHTDHSLEHYKRNEEWHLLNLNVSEEKYEHEGVEVSEVKFEISLKRRPLFYMVTLTFPSYIMCAISVVGLFARFSTTGEREERFTLGVTAILTMAVLSLVVSEKVPHSSTHVPLLVAYFLFNMVIVSIAAMTTGIVMKVHRLGRYGDEPSDFWMRCFLLKPVFRTSNRRKYRMNPEEPTQVILVSEAKNGEVLTKKSTELNGTVVKEIMLSSRLEALEEYIRKMVNRCETIKWELDEIDAAENIELVRRRSTNGYVRISERLDILFMFLFLSTVTIPVAVLFYLT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>P34623-2</accession>
    <name>DDRGK_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of DDRGK domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ufm-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ufbp-1</name>
        <name evidence="3" type="ORF">ZK1236.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34623-2</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_057668"/>
        </isoform>
        <isoform>
            <id>P34623-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001254959.1">
        <property type="nucleotide sequence ID" value="NM_001268030.4"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK1236.7a">
        <property type="protein sequence ID" value="CE29628"/>
        <property type="gene ID" value="WBGene00022865"/>
        <property type="gene designation" value="ufbp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="ZK1236.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK1236.7b"/>
        </source>
    </evidence>
    <sequence length="324" mass="37446" checksum="AED779E03804435D" modified="2010-03-02" version="3">MDNNQEKSTDSPYSFGGTKDDGMDPLLLGSVGVLVLAVTLIIWRLLKLQWDEKAARQRTDMLLAMNEGAGGSDERRGANVAGGMRRNARRRVNRDEQEDGFVNHMMNDGEDVEDLDGGAEQFEYDEDGKKIGKRKAAKLQAKEEKRQMREYEVREREERKRREEEREKKRDEERAKEEADEKAEEERLRKEREEKERKEHEEYLAMKASFAIEEEGTDAIEGEEAENLIRDFVDYVKTNKVVNIDELSSHFGLKSEDAVNRLQHFIEEGLVQGVMDDRGKFIYISDEEFAAVAKFINQRGRVSIHEIAEQSNRLIRLETPSAAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q09550-7</accession>
    <name>YQU3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Uncharacterized protein F26C11.3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">F26C11.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09550-10</id>
            <name evidence="5">f</name>
            <sequence type="described" ref="VSP_062614"/>
        </isoform>
        <isoform>
            <id>Q09550-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09550-9</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_062613"/>
        </isoform>
        <isoform>
            <id>Q09550-7</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_062612"/>
        </isoform>
        <isoform>
            <id>Q09550-8</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_062615"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="F26C11.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F26C11.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F26C11.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F26C11.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F26C11.3f"/>
        </source>
    </evidence>
    <sequence length="1249" mass="132828" checksum="25C3517F2A39993E" modified="2026-01-28" version="5" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q09550-8</accession>
    <name>YQU3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Uncharacterized protein F26C11.3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">F26C11.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09550-10</id>
            <name evidence="5">f</name>
            <sequence type="described" ref="VSP_062614"/>
        </isoform>
        <isoform>
            <id>Q09550-7</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_062612"/>
        </isoform>
        <isoform>
            <id>Q09550-9</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_062613"/>
        </isoform>
        <isoform>
            <id>Q09550-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09550-8</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_062615"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="F26C11.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F26C11.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F26C11.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F26C11.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F26C11.3f"/>
        </source>
    </evidence>
    <sequence length="1279" mass="136329" checksum="AD60BB728FADA06E" modified="2026-01-28" version="5" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q09550-9</accession>
    <name>YQU3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform d of Uncharacterized protein F26C11.3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">F26C11.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09550-8</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_062615"/>
        </isoform>
        <isoform>
            <id>Q09550-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09550-10</id>
            <name evidence="5">f</name>
            <sequence type="described" ref="VSP_062614"/>
        </isoform>
        <isoform>
            <id>Q09550-7</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_062612"/>
        </isoform>
        <isoform>
            <id>Q09550-9</id>
            <name evidence="4">d</name>
            <sequence type="described" ref="VSP_062613"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="F26C11.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F26C11.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F26C11.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F26C11.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F26C11.3f"/>
        </source>
    </evidence>
    <sequence length="1278" mass="135990" checksum="A93D08F23CFEF50A" modified="2026-01-28" version="5" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-02" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>Q10572-2</accession>
    <name>FOX1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Sex determination protein fox-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Feminizing locus on X protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fox-1</name>
        <name evidence="3" type="ORF">T07D1.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Development" volume="120" first="3681" last="3689">
            <title>Identification of a candidate primary sex determination locus, fox-1, on the X chromosome of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hodgkin J."/>
                <person name="Zellan J.D."/>
                <person name="Albertson D.G."/>
            </authorList>
            <dbReference type="PubMed" id="7821230"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>CB1489</strain>
            <tissue>Embryo</tissue>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Nature" volume="388" first="200" last="204">
            <title>X-chromosome-counting mechanisms that determine nematode sex.</title>
            <authorList>
                <person name="Nicoll M."/>
                <person name="Akerib C.C."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="9217163"/>
            <dbReference type="DOI" id="10.1038/40645"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1999" name="Genetics" volume="151" first="617" last="631">
            <title>Genetic and molecular analysis of fox-1, a numerator element involved in Caenorhabditis elegans primary sex determination.</title>
            <authorList>
                <person name="Skipper M."/>
                <person name="Milne C.A."/>
                <person name="Hodgkin J."/>
            </authorList>
            <dbReference type="PubMed" id="9927456"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="J. Mol. Neurosci." volume="15" first="231" last="241">
            <title>The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans.</title>
            <authorList>
                <person name="Kiehl T.R."/>
                <person name="Shibata H."/>
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            <dbReference type="DOI" id="10.1385/JMN:15:3:231"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Dev. Cell" volume="9" first="339" last="349">
            <title>The T-box transcription factor SEA-1 is an autosomal element of the X:A signal that determines C. elegans sex.</title>
            <authorList>
                <person name="Powell J.R."/>
                <person name="Jow M.M."/>
                <person name="Meyer B.J."/>
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            <dbReference type="DOI" id="10.1016/j.devcel.2005.06.009"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2006" name="Nat. Methods" volume="3" first="909" last="915">
            <title>Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo.</title>
            <authorList>
                <person name="Kuroyanagi H."/>
                <person name="Kobayashi T."/>
                <person name="Mitani S."/>
                <person name="Hagiwara M."/>
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            <dbReference type="PubMed" id="17060915"/>
            <dbReference type="DOI" id="10.1038/nmeth944"/>
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        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2007" name="Genetics" volume="177" first="1621" last="1637">
            <title>A ONECUT homeodomain protein communicates X chromosome dose to specify Caenorhabditis elegans sexual fate by repressing a sex switch gene.</title>
            <authorList>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="17720939"/>
            <dbReference type="DOI" id="10.1534/genetics.106.061812"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2007" name="Mol. Cell. Biol." volume="27" first="8612" last="8621">
            <title>The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo.</title>
            <authorList>
                <person name="Kuroyanagi H."/>
                <person name="Ohno G."/>
                <person name="Mitani S."/>
                <person name="Hagiwara M."/>
            </authorList>
            <dbReference type="PubMed" id="17923701"/>
            <dbReference type="DOI" id="10.1128/MCB.01508-07"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SUP-12</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="1159" last="1178">
            <title>Molecular antagonism between X-chromosome and autosome signals determines nematode sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Nix P."/>
                <person name="Jow M.M."/>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="23666922"/>
            <dbReference type="DOI" id="10.1101/gad.217026.113"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="e1003337" last="e1003337">
            <title>CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kuroyanagi H."/>
                <person name="Watanabe Y."/>
                <person name="Hagiwara M."/>
            </authorList>
            <dbReference type="PubMed" id="23468662"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003337"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF 423-LEU--TYR-429</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determine C. elegans sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Novak C.S."/>
                <person name="Nicoll M."/>
                <person name="Quiogue A."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="33372658"/>
            <dbReference type="DOI" id="10.7554/elife.62963"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q10572-3</id>
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        <recommendedName>
            <fullName>Isoform b of Sex determination protein fox-1</fullName>
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            <fullName>Feminizing locus on X protein 1</fullName>
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    <reference key="1">
        <citation type="journal article" date="1994" name="Development" volume="120" first="3681" last="3689">
            <title>Identification of a candidate primary sex determination locus, fox-1, on the X chromosome of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hodgkin J."/>
                <person name="Zellan J.D."/>
                <person name="Albertson D.G."/>
            </authorList>
            <dbReference type="PubMed" id="7821230"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>CB1489</strain>
            <tissue>Embryo</tissue>
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    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Nature" volume="388" first="200" last="204">
            <title>X-chromosome-counting mechanisms that determine nematode sex.</title>
            <authorList>
                <person name="Nicoll M."/>
                <person name="Akerib C.C."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="9217163"/>
            <dbReference type="DOI" id="10.1038/40645"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1999" name="Genetics" volume="151" first="617" last="631">
            <title>Genetic and molecular analysis of fox-1, a numerator element involved in Caenorhabditis elegans primary sex determination.</title>
            <authorList>
                <person name="Skipper M."/>
                <person name="Milne C.A."/>
                <person name="Hodgkin J."/>
            </authorList>
            <dbReference type="PubMed" id="9927456"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="J. Mol. Neurosci." volume="15" first="231" last="241">
            <title>The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans.</title>
            <authorList>
                <person name="Kiehl T.R."/>
                <person name="Shibata H."/>
                <person name="Pulst S.M."/>
            </authorList>
            <dbReference type="PubMed" id="11303786"/>
            <dbReference type="DOI" id="10.1385/JMN:15:3:231"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Dev. Cell" volume="9" first="339" last="349">
            <title>The T-box transcription factor SEA-1 is an autosomal element of the X:A signal that determines C. elegans sex.</title>
            <authorList>
                <person name="Powell J.R."/>
                <person name="Jow M.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="16139225"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2005.06.009"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2006" name="Nat. Methods" volume="3" first="909" last="915">
            <title>Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo.</title>
            <authorList>
                <person name="Kuroyanagi H."/>
                <person name="Kobayashi T."/>
                <person name="Mitani S."/>
                <person name="Hagiwara M."/>
            </authorList>
            <dbReference type="PubMed" id="17060915"/>
            <dbReference type="DOI" id="10.1038/nmeth944"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2007" name="Genetics" volume="177" first="1621" last="1637">
            <title>A ONECUT homeodomain protein communicates X chromosome dose to specify Caenorhabditis elegans sexual fate by repressing a sex switch gene.</title>
            <authorList>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="17720939"/>
            <dbReference type="DOI" id="10.1534/genetics.106.061812"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2007" name="Mol. Cell. Biol." volume="27" first="8612" last="8621">
            <title>The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo.</title>
            <authorList>
                <person name="Kuroyanagi H."/>
                <person name="Ohno G."/>
                <person name="Mitani S."/>
                <person name="Hagiwara M."/>
            </authorList>
            <dbReference type="PubMed" id="17923701"/>
            <dbReference type="DOI" id="10.1128/MCB.01508-07"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SUP-12</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="1159" last="1178">
            <title>Molecular antagonism between X-chromosome and autosome signals determines nematode sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Nix P."/>
                <person name="Jow M.M."/>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="23666922"/>
            <dbReference type="DOI" id="10.1101/gad.217026.113"/>
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        <scope>FUNCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="e1003337" last="e1003337">
            <title>CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kuroyanagi H."/>
                <person name="Watanabe Y."/>
                <person name="Hagiwara M."/>
            </authorList>
            <dbReference type="PubMed" id="23468662"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003337"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF 423-LEU--TYR-429</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determine C. elegans sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Novak C.S."/>
                <person name="Nicoll M."/>
                <person name="Quiogue A."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="33372658"/>
            <dbReference type="DOI" id="10.7554/elife.62963"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q10572-2</id>
            <name evidence="1">a</name>
            <sequence type="described" ref="VSP_060630"/>
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        <isoform>
            <id>Q10572-3</id>
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            <sequence type="described" ref="VSP_060629"/>
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    <accession>Q17802-2</accession>
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            <fullName>Isoform b of Chondroitin proteoglycan 1</fullName>
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            <fullName>Cytokinesis protein cej-1</fullName>
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    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Mol. Cell" volume="6" first="605" last="616">
            <title>A global profile of germline gene expression in C. elegans.</title>
            <authorList>
                <person name="Reinke V."/>
                <person name="Smith H.E."/>
                <person name="Nance J."/>
                <person name="Wang J."/>
                <person name="Van Doren C."/>
                <person name="Begley R."/>
                <person name="Jones S.J.M."/>
                <person name="Davis E.B."/>
                <person name="Scherer S."/>
                <person name="Ward S."/>
                <person name="Kim S.K."/>
            </authorList>
            <dbReference type="PubMed" id="11030340"/>
            <dbReference type="DOI" id="10.1016/S1097-2765(00)00059-9"/>
        </citation>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2001" name="Genes Dev." volume="15" first="2408" last="2420">
            <title>Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development.</title>
            <authorList>
                <person name="Lee M.-H."/>
                <person name="Schedl T."/>
            </authorList>
            <dbReference type="PubMed" id="11562350"/>
            <dbReference type="DOI" id="10.1101/gad.915901"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="BMC Biol." volume="4" first="35" last="35">
            <title>The eggshell is required for meiotic fidelity, polar-body extrusion and polarization of the C. elegans embryo.</title>
            <authorList>
                <person name="Johnston W.L."/>
                <person name="Krizus A."/>
                <person name="Dennis J.W."/>
            </authorList>
            <dbReference type="PubMed" id="17042944"/>
            <dbReference type="DOI" id="10.1186/1741-7007-4-35"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="J. Cell Biol." volume="173" first="985" last="994">
            <title>Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2.</title>
            <authorList>
                <person name="Olson S.K."/>
                <person name="Bishop J.R."/>
                <person name="Yates J.R."/>
                <person name="Oegema K."/>
                <person name="Esko J.D."/>
            </authorList>
            <dbReference type="PubMed" id="16785326"/>
            <dbReference type="DOI" id="10.1083/jcb.200603003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>GLYCOSYLATION AT SER-50</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="Development" volume="134" first="3837" last="3848">
            <title>Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase.</title>
            <authorList>
                <person name="Bembenek J.N."/>
                <person name="Richie C.T."/>
                <person name="Squirrell J.M."/>
                <person name="Campbell J.M."/>
                <person name="Eliceiri K.W."/>
                <person name="Poteryaev D."/>
                <person name="Spang A."/>
                <person name="Golden A."/>
                <person name="White J.G."/>
            </authorList>
            <dbReference type="PubMed" id="17913784"/>
            <dbReference type="DOI" id="10.1242/dev.011361"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
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        <event type="alternative splicing"/>
        <isoform>
            <id>Q17802-2</id>
            <name evidence="1">b</name>
            <sequence type="described" ref="VSP_050569"/>
        </isoform>
        <isoform>
            <id>Q17802-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
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    <dbReference type="RefSeq" id="NP_001021160.1">
        <property type="nucleotide sequence ID" value="NM_001025989.5"/>
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    <dbReference type="WormBase" id="C07G2.1b">
        <property type="protein sequence ID" value="CE33971"/>
        <property type="gene ID" value="WBGene00000465"/>
        <property type="gene designation" value="cpg-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="160" mass="16897" checksum="0C6F93A63073925C" modified="1996-11-01" version="1" precursor="true">MTLKPVLLAFLVASAYAQYGVAGMYENLPLETTTLDGSGDGSGADNGFVSGADAVAIDTDCSTKEDGLYAIGGCSPQFLTCSGGISRIMDCPADLIYDPRIVACEYSYNVPQCGGVPQDVTSTQEAIFICENGLFFSPEQARCAPADQIAECHQTTVQYY</sequence>
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    <accession>Q6A582</accession>
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            <taxon>Rhabditina</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">Bristol N2</strain>
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    <dbReference type="AlphaFoldDB" id="Q6A582"/>
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    <dbReference type="CTD" id="175595"/>
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        <property type="gene ID" value="WBGene00010908"/>
        <property type="gene designation" value="imph-1"/>
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    <dbReference type="OrthoDB" id="752362at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
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    <dbReference type="Bgee" id="WBGene00010908">
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    <dbReference type="ExpressionAtlas" id="Q6A582">
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    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
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    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
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            <end position="261"/>
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    <feature type="domain" description="K Homology" evidence="4">
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            <begin position="1"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SMART" id="SM00322"/>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH10787.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="M88.5b"/>
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    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q6A582"/>
        </source>
    </evidence>
    <sequence length="704" mass="78335" checksum="339B2B3D610952C3" modified="2004-09-13" version="1"> </sequence>
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    <accession>Q6A583</accession>
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        <recommendedName>
            <fullName evidence="3">Solute carrier family 12 member 9</fullName>
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    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the SLC12A transporter family.</text>
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    <dbReference type="SMR" id="Q6A583"/>
    <dbReference type="GeneID" id="173453"/>
    <dbReference type="UCSC" id="T04B8.5b">
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    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020207"/>
    <dbReference type="CTD" id="173453"/>
    <dbReference type="WormBase" id="T04B8.5b">
        <property type="protein sequence ID" value="CE37041"/>
        <property type="gene ID" value="WBGene00020207"/>
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    <dbReference type="OrthoDB" id="2020542at2759"/>
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    </dbReference>
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    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
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            <end position="91"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="129"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="169"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="481"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="512"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="575"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF03522"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD72774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T04B8.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q6A583"/>
        </source>
    </evidence>
    <sequence length="939" mass="103519" checksum="765E8ED6539825F0" modified="2004-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6A585</accession>
    <name>Q6A585_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2 4" type="primary">bath-28</name>
        <name evidence="2" type="ORF">CELE_F14D2.13</name>
        <name evidence="4" type="ORF">F14D2.13</name>
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    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_871999.2">
        <property type="nucleotide sequence ID" value="NM_182199.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6A585"/>
    <dbReference type="GeneID" id="259426"/>
    <dbReference type="UCSC" id="F14D2.13b">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00017461"/>
    <dbReference type="CTD" id="259426"/>
    <dbReference type="WormBase" id="F14D2.13a">
        <property type="protein sequence ID" value="CE36998"/>
        <property type="gene ID" value="WBGene00017461"/>
        <property type="gene designation" value="bath-28"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030831_3_0_1"/>
    <dbReference type="OrthoDB" id="5911064at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017461">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6A585">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="CDD" id="cd22150">
        <property type="entry name" value="F-box_CeFBXA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002900">
        <property type="entry name" value="DUF38/FTH_CAE_spp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040161">
        <property type="entry name" value="FB224"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23015:SF4">
        <property type="entry name" value="DUF38 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23015">
        <property type="entry name" value="UNCHARACTERIZED C.ELEGANS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01827">
        <property type="entry name" value="FTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD69487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F14D2.13a"/>
        </source>
    </evidence>
    <sequence length="249" mass="28115" checksum="B9789C0C3A5B977B" modified="2004-09-13" version="1">MADKLANVLDSIKISSAPTLIPDNLDPINSSDDSSLSDLSMETAPETFFSEPPTLSDMSMEVLGKIVENLDPFNRLSVRKVCRKLRDAIDSTDPGFKTVEVRVTDDMCLLWANSQSSFYSMTVSGGIIKGTKRSEKSEFTSLNGLLDELAVVLKNPRLQLDKLVIYATMEQGNIVKWFEASNPIHTKMLKLSGFELSDFIFLLSRFKPGVLEEIDISWYLHLANTPFTRNYRLTDLFEMEQWKQAKSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2025-10-08" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6A592</accession>
    <name>Q6A592_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">slc-17.8</name>
        <name evidence="8" type="ORF">CELE_F25G6.7</name>
        <name evidence="10" type="ORF">F25G6.7</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD64108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023849.1">
        <property type="nucleotide sequence ID" value="NM_001028678.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6A592"/>
    <dbReference type="SMR" id="Q6A592"/>
    <dbReference type="GeneID" id="179234"/>
    <dbReference type="UCSC" id="F25G6.7b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017798"/>
    <dbReference type="CTD" id="179234"/>
    <dbReference type="WormBase" id="F25G6.7b">
        <property type="protein sequence ID" value="CE37007"/>
        <property type="gene ID" value="WBGene00017798"/>
        <property type="gene designation" value="slc-17.8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_0_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017798">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6A592">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000673">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF331">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD64108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F25G6.7b"/>
        </source>
    </evidence>
    <sequence length="513" mass="56796" checksum="4E8B0BD2A0844518" modified="2004-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2025-10-08" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6A593</accession>
    <name>Q6A593_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">alh-6</name>
        <name evidence="4" type="ORF">CELE_F56D12.1</name>
        <name evidence="6" type="ORF">F56D12.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD64343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022212.1">
        <property type="nucleotide sequence ID" value="NM_001027041.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6A593"/>
    <dbReference type="SMR" id="Q6A593"/>
    <dbReference type="PeptideAtlas" id="Q6A593"/>
    <dbReference type="GeneID" id="173510"/>
    <dbReference type="KEGG" id="cel:CELE_F56D12.1"/>
    <dbReference type="UCSC" id="F56D12.1c.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000112"/>
    <dbReference type="CTD" id="173510"/>
    <dbReference type="WormBase" id="F56D12.1c">
        <property type="protein sequence ID" value="CE37118"/>
        <property type="gene ID" value="WBGene00000112"/>
        <property type="gene designation" value="alh-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049328_0_0_1"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000112">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6A593">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000095">
        <property type="entry name" value="ALdehyde deHydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
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        <property type="entry name" value="Ald_DH_C"/>
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        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD64343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F56D12.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q6A593"/>
        </source>
    </evidence>
    <sequence length="394" mass="43528" checksum="9D301D0EC89F2D58" modified="2004-09-13" version="1">MLSFAARRSLITQKCAASTYSGLTSADFLKKKTNEPILEYRKGSKERQDLEAALAFYSKNITEVPLRIGDKKITNKLEQKQVIPSDHRSTLAKYTYATGEQIQEAIDVALQARGAWERKPLKERAEILLRAADLAAGKYRMKLNASTMLGQGKNIIQAEIDAACELIDFFRFNAVFAMELEHYEPISTKITKNTMQFRGMEGFVAAIAPFNFTAIGGNLPTAPALMGNVSLWKPSNTAVLSNYIIYELLEEAGMPPGILSFLPSDGPVFGDVITASPHLSAVNFTGSVPTFKTIWRKVAENLDNYVTFPKLIGECGGKNFHFVHPSAHVDAVAAGTARSAWEYSGQKCSACSRMYAPKSIWPKILEKISAIHKEIKLGDFTGSRWIRLSVGCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6A598</accession>
    <name>Q6A598_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Insulin-degrading enzyme</fullName>
            <ecNumber evidence="8">3.4.24.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Insulin protease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Insulysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CELE_F44E7.4</name>
        <name evidence="16 18" type="ORF">F44E7.4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Degradation of insulin, glucagon and other polypeptides. No action on proteins.</text>
            <dbReference type="EC" id="3.4.24.56"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.56" evidence="8"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD67863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023928.1">
        <property type="nucleotide sequence ID" value="NM_001028757.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6A598"/>
    <dbReference type="SMR" id="Q6A598"/>
    <dbReference type="MEROPS" id="M16.A09"/>
    <dbReference type="PeptideAtlas" id="Q6A598"/>
    <dbReference type="GeneID" id="178966"/>
    <dbReference type="KEGG" id="cel:CELE_F44E7.4"/>
    <dbReference type="UCSC" id="F44E7.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018426"/>
    <dbReference type="CTD" id="178966"/>
    <dbReference type="WormBase" id="F44E7.4d">
        <property type="protein sequence ID" value="CE37110"/>
        <property type="gene ID" value="WBGene00018426"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004639_1_1_1"/>
    <dbReference type="OrthoDB" id="7784541at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018426">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6A598">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000066">
        <property type="entry name" value="Putative zinc protease mug138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="13">
        <location>
            <begin position="95"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="14">
        <location>
            <begin position="259"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="15">
        <location>
            <begin position="444"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="15">
        <location>
            <begin position="667"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="14">
        <location>
            <begin position="747"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD67863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="F44E7.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="Q6A598"/>
        </source>
    </evidence>
    <sequence length="984" mass="112502" checksum="D39CA3702BB758C4" modified="2004-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6AW10</accession>
    <name>Q6AW10_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar phosphate transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_Y47G6A.7</name>
        <name evidence="8 10" type="ORF">Y47G6A.7</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD72552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021770.1">
        <property type="nucleotide sequence ID" value="NM_001026599.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6AW10"/>
    <dbReference type="SMR" id="Q6AW10"/>
    <dbReference type="GeneID" id="171918"/>
    <dbReference type="UCSC" id="Y47G6A.7b.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021637"/>
    <dbReference type="CTD" id="171918"/>
    <dbReference type="WormBase" id="Y47G6A.7b">
        <property type="protein sequence ID" value="CE37067"/>
        <property type="gene ID" value="WBGene00021637"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022332_1_3_1"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021637">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6AW10">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="79"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD72552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y47G6A.7b"/>
        </source>
    </evidence>
    <sequence length="401" mass="45414" checksum="BD9DDA97ECE27F4A" modified="2004-09-13" version="1">MRFPSTFSSSTHHLLESSPIDDDPGPSESIALQTRVPTATTAEKLVAEISDESDEEDEDLHFRSVNETTNQTYSEMVLRIALIAMIYYPLSIGLTFYQKWFIKNYKLPLLVVSGHYVLKYLFAITIRFIYECLRTRRTRVSFRDQLRWLAPIGICASMDIGLSNWALEYVTVSLYTMAKSSSILFIVAFSLLLRLERWRNSLGFETGLIAAGLFLFTWKSSQLDLTGLMLVELAAACTGIRWTVSQMVMQRDDSAVRHPLDMVAHVQPWMMIPIIPMIWLFEGAEINWNSVFSFKGHYDPWLVMGLIAGGGLLAFCMEMSEYLLLVNTSGITLNIFGIVKEVATLLLAHIVNKDTLTELNICGLVLCLSGMLLHGMNKRHQRLSRISADTDHQYSLLSKTV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I7F8-2</accession>
    <name>ODR4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Odorant response abnormal protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">odr-4</name>
        <name type="ORF">Y102E9.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Cell" volume="74" first="515" last="527">
            <title>Odorant-selective genes and neurons mediate olfaction in C. elegans.</title>
            <authorList>
                <person name="Bargmann C.I."/>
                <person name="Hartwieg E."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="8348618"/>
            <dbReference type="DOI" id="10.1016/0092-8674(93)80053-H"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Cell" volume="93" first="455" last="466">
            <title>Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein.</title>
            <authorList>
                <person name="Dwyer N.D."/>
                <person name="Troemel E.R."/>
                <person name="Sengupta P."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="9590179"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(00)81173-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Curr. Biol." volume="16" first="649" last="659">
            <title>Behavioral motifs and neural pathways coordinating O2 responses and aggregation in C. elegans.</title>
            <authorList>
                <person name="Rogers C."/>
                <person name="Persson A."/>
                <person name="Cheung B."/>
                <person name="de Bono M."/>
            </authorList>
            <dbReference type="PubMed" id="16581509"/>
            <dbReference type="DOI" id="10.1016/j.cub.2006.03.023"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="PLoS Genet." volume="10" first="E1004082" last="E1004082">
            <title>An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism.</title>
            <authorList>
                <person name="Chen C."/>
                <person name="Itakura E."/>
                <person name="Weber K.P."/>
                <person name="Hegde R.S."/>
                <person name="de Bono M."/>
            </authorList>
            <dbReference type="PubMed" id="24603482"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004082"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ODR-8 AND ODR-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q8I7F8-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q8I7F8-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_028104"/>
        </isoform>
        <isoform>
            <id>Q8I7F8-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_038346 VSP_038345"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001370710.1">
        <property type="nucleotide sequence ID" value="NM_001382900.2"/>
    </dbReference>
    <dbReference type="WormBase" id="Y102E9.1a">
        <property type="protein sequence ID" value="CE28101"/>
        <property type="gene ID" value="WBGene00003851"/>
        <property type="gene designation" value="odr-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="445" mass="50217" checksum="5FD6AA6558794A27" modified="2003-03-01" version="1">MILFDVQLQEWVTKSAKNHEFVLSDKGIPASAYFLLGSFCSDGDIHVAYASKCPVHSSALEENATESSKMLEDEWMSDHAERLLRMLPGGIHVVGIAWFSDKKTFSDRKSHIHKTLGRIQKMNNQITTANVDDSISDNMITVFFETPSTTPIGAIIDVTNRGNDSAQKVQFQKLEWISLVTNASARIVHNVPVDTGRPTDFYSDLVVATKNFVNNLFQCEFTLLDGEIRDDKEPLIKDIKKNKKTTIEAQLFLNPLFLDNRELGAIDDIASNMHEVLFDIEVRAAVPIRSTVKDAIRAIKHHLVRNLFARVELHYESMEVVEEERSPKTGITVHQLPRPATTVLYTHPAILINDFLFEADNVEDAQKNFDDMMDLQTSIEHVDEGWERALTPEEMEAVRTPIEDLHFVDFDGSSDSWCTTKTILITIALIIGLLASIIYFTVAHS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I7F8-3</accession>
    <name>ODR4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Odorant response abnormal protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">odr-4</name>
        <name type="ORF">Y102E9.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Cell" volume="74" first="515" last="527">
            <title>Odorant-selective genes and neurons mediate olfaction in C. elegans.</title>
            <authorList>
                <person name="Bargmann C.I."/>
                <person name="Hartwieg E."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="8348618"/>
            <dbReference type="DOI" id="10.1016/0092-8674(93)80053-H"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Cell" volume="93" first="455" last="466">
            <title>Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein.</title>
            <authorList>
                <person name="Dwyer N.D."/>
                <person name="Troemel E.R."/>
                <person name="Sengupta P."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="9590179"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(00)81173-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Curr. Biol." volume="16" first="649" last="659">
            <title>Behavioral motifs and neural pathways coordinating O2 responses and aggregation in C. elegans.</title>
            <authorList>
                <person name="Rogers C."/>
                <person name="Persson A."/>
                <person name="Cheung B."/>
                <person name="de Bono M."/>
            </authorList>
            <dbReference type="PubMed" id="16581509"/>
            <dbReference type="DOI" id="10.1016/j.cub.2006.03.023"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="PLoS Genet." volume="10" first="E1004082" last="E1004082">
            <title>An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism.</title>
            <authorList>
                <person name="Chen C."/>
                <person name="Itakura E."/>
                <person name="Weber K.P."/>
                <person name="Hegde R.S."/>
                <person name="de Bono M."/>
            </authorList>
            <dbReference type="PubMed" id="24603482"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004082"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ODR-8 AND ODR-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q8I7F8-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_038345 VSP_038346"/>
        </isoform>
        <isoform>
            <id>Q8I7F8-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q8I7F8-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_028104"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022815.1">
        <property type="nucleotide sequence ID" value="NM_001027644.9"/>
    </dbReference>
    <dbReference type="WormBase" id="Y102E9.1c">
        <property type="protein sequence ID" value="CE32954"/>
        <property type="gene ID" value="WBGene00003851"/>
        <property type="gene designation" value="odr-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="473" mass="53497" checksum="354778778580DB70" modified="2003-03-01" version="1">MTRNRRKSKTTATSHPELHLEKVDPMKTESMILFDVQLQEWVTKSAKNHEFVLSDKGIPASAYFLLGSFCSDGDIHVAYASKCPVHSSALEENATESSKMLEDEWMSDHAERLLRMLPGGIHVVGIAWFSDKKTFSDRKSHIHKTLGRIQKMNNQITTANVDDSISDNMITVFFETPSTTPIGAIIDVTNRGNDSAQKVQFQKLEWISLVTNASARIVHNVPVDTGRPTDFYSDLVVATKNFVNNLFQCEFTLLDGEIRDDKEPLIKDIKKNKKTTIEAQLFLNPLYNRELGAIDDIASNMHEVLFDIEVRAAVPIRSTVKDAIRAIKHHLVRNLFARVELHYESMEVVEEERSPKTGITVHQLPRPATTVLYTHPAILINDFLFEADNVEDAQKNFDDMMDLQTSIEHVDEGWERALTPEEMEAVRTPIEDLHFVDFDGSSDSWCTTKTILITIALIIGLLASIIYFTVAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IA69</accession>
    <name>Q8IA69_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein PXR1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C45H4.14</name>
        <name evidence="2" type="ORF">CELE_C45H4.14</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD67424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_872168.1">
        <property type="nucleotide sequence ID" value="NM_182368.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IA69"/>
    <dbReference type="SMR" id="Q8IA69"/>
    <dbReference type="GeneID" id="178694"/>
    <dbReference type="UCSC" id="C45H4.14a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016695"/>
    <dbReference type="CTD" id="178694"/>
    <dbReference type="WormBase" id="C45H4.14b">
        <property type="protein sequence ID" value="CE32829"/>
        <property type="gene ID" value="WBGene00016695"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129474_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016695">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IA69">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD67424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C45H4.14b"/>
        </source>
    </evidence>
    <sequence length="131" mass="15245" checksum="43004BFD2985FFCF" modified="2003-03-01" version="1">MDGLDPYDEMEISCKSILKKLDEKKKTEEKHRAKQERQAQKKGAKEQAKKEKAELKKEAKELLKKEKAEERKKESLKRKLSEKSEPAAKKAKASEDQENRGATKKKITPPNRKHTALFKKCMAMRVKNFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2025-10-08" version="182" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IA76</accession>
    <name>Q8IA76_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="4">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">pll-1</name>
        <name evidence="8" type="ORF">CELE_K10F12.3</name>
        <name evidence="10" type="ORF">K10F12.3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 4">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="4"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD72879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741067.1">
        <property type="nucleotide sequence ID" value="NM_171059.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IA76"/>
    <dbReference type="SMR" id="Q8IA76"/>
    <dbReference type="GeneID" id="187273"/>
    <dbReference type="KEGG" id="cel:CELE_K10F12.3"/>
    <dbReference type="UCSC" id="K10F12.3b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004045"/>
    <dbReference type="CTD" id="187273"/>
    <dbReference type="WormBase" id="K10F12.3b">
        <property type="protein sequence ID" value="CE31037"/>
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        <property type="gene designation" value="pll-1"/>
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    </dbReference>
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        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="7">
        <location>
            <begin position="545"/>
            <end position="666"/>
        </location>
    </feature>
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        <location>
            <begin position="664"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD72879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="K10F12.3b"/>
        </source>
    </evidence>
    <sequence length="1068" mass="120043" checksum="9BF7CFCFFD7EC221" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IAA4</accession>
    <name>Q8IAA4_CAEEL</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">phf-15</name>
        <name evidence="8" type="ORF">CELE_Y53G8AR.2</name>
        <name evidence="10" type="ORF">Y53G8AR.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_871639.1">
        <property type="nucleotide sequence ID" value="NM_181910.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IAA4"/>
    <dbReference type="SMR" id="Q8IAA4"/>
    <dbReference type="PeptideAtlas" id="Q8IAA4"/>
    <dbReference type="GeneID" id="175435"/>
    <dbReference type="UCSC" id="Y53G8AR.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021810"/>
    <dbReference type="CTD" id="175435"/>
    <dbReference type="WormBase" id="Y53G8AR.2b">
        <property type="protein sequence ID" value="CE33233"/>
        <property type="gene ID" value="WBGene00021810"/>
        <property type="gene designation" value="phf-15"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_364566_0_0_1"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021810">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IAA4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF143">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="237"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="293"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="635"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD73812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y53G8AR.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q8IAA4"/>
        </source>
    </evidence>
    <sequence length="700" mass="79721" checksum="BD4A88E5DA1F1D5B" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="177" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IAA6</accession>
    <name>Q8IAA6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="14">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CELE_Y47G6A.5</name>
        <name evidence="19 21" type="ORF">Y47G6A.5</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
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    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD72549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_871806.1">
        <property type="nucleotide sequence ID" value="NM_182006.3"/>
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    <dbReference type="AlphaFoldDB" id="Q8IAA6"/>
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        <property type="interactions" value="2"/>
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    <dbReference type="PeptideAtlas" id="Q8IAA6"/>
    <dbReference type="GeneID" id="189992"/>
    <dbReference type="UCSC" id="Y47G6A.5a">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00021635"/>
    <dbReference type="CTD" id="189992"/>
    <dbReference type="WormBase" id="Y47G6A.5b">
        <property type="protein sequence ID" value="CE33228"/>
        <property type="gene ID" value="WBGene00021635"/>
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    <dbReference type="HOGENOM" id="CLU_000288_7_2_1"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
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    <dbReference type="Bgee" id="WBGene00021635">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:axon development"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0048680">
        <property type="term" value="P:positive regulation of axon regeneration"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd00192">
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        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd00173">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000180">
        <property type="entry name" value="serine/threonine-protein kinase STY46-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000397">
        <property type="entry name" value="Tyrosine-protein kinase"/>
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        <property type="entry name" value="SH3 Domains"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TYRKINASE"/>
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    <dbReference type="SMART" id="SM00252">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="94"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="159"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="284"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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        <source>
            <dbReference type="RuleBase" id="RU362096"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCD72549.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PeptideAtlas" id="Q8IAA6"/>
        </source>
    </evidence>
    <sequence length="574" mass="64972" checksum="87F26FCF51766ECC" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IAA7</accession>
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        <submittedName>
            <fullName evidence="3">ING domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">CELE_Y43H11AL.1</name>
        <name evidence="3 5" type="ORF">Y43H11AL.1</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="CE32968"/>
        <property type="gene ID" value="WBGene00021545"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5411773at2759"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="226"/>
        </location>
    </feature>
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        <location>
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            <end position="367"/>
        </location>
    </feature>
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            <begin position="60"/>
            <end position="87"/>
        </location>
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        <location>
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            <end position="151"/>
        </location>
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        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD71488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y43H11AL.1a"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IAB0</accession>
    <name>Q8IAB0_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y71F9B.13</name>
        <name evidence="2 4" type="ORF">Y71F9B.13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD70421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IAB0"/>
    <dbReference type="SMR" id="Q8IAB0"/>
    <dbReference type="UCSC" id="Y71F9B.13c">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022131"/>
    <dbReference type="WormBase" id="Y71F9B.13c">
        <property type="protein sequence ID" value="CE33244"/>
        <property type="gene ID" value="WBGene00022131"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1257072_0_0_1"/>
    <dbReference type="OrthoDB" id="5828367at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022131">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IAB0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD70421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y71F9B.13c"/>
        </source>
    </evidence>
    <sequence length="95" mass="11432" checksum="2C7AC0D57DA86A25" modified="2003-03-01" version="1">MAQLENDYKFAKGGHYPYNRADNIVNIGLQQTYLPTCLHDLFYCVRASNGQRPQAYLNYKEYRRDRDQAAEQMAQRDQDIKTLRRHRTRHHEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IAB4</accession>
    <name>Q8IAB4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luc7-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y119D3B.12</name>
        <name evidence="3 5" type="ORF">Y119D3B.12</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD73922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IAB4"/>
    <dbReference type="SMR" id="Q8IAB4"/>
    <dbReference type="PeptideAtlas" id="Q8IAB4"/>
    <dbReference type="UCSC" id="Y119D3B.12b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022489"/>
    <dbReference type="WormBase" id="Y119D3B.12b">
        <property type="protein sequence ID" value="CE27239"/>
        <property type="gene ID" value="WBGene00022489"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030397_0_0_1"/>
    <dbReference type="OrthoDB" id="10266921at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022489">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IAB4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="87"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD73922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y119D3B.12b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q8IAB4"/>
        </source>
    </evidence>
    <sequence length="224" mass="26233" checksum="6F7812F816E18CA9" modified="2003-03-01" version="1">MTDYMAQMLNELMGSQRDANPGERREIRYDDPNVCTDFLVGFCTHDIFRNTKNDLGFCKYTTHDENLKNSYKNSDKKWRMGFEKRFLERIRRIHEDVRRKIQKHEDRLAVTQGESKSAEETFGQKILEIEQRREQLTKKMEDLMDEAALEGEKGNVDAAQTAVDRADKAKVEVEELTQEAEKLKSEKERAINMEENVTAAPLDRRRRRRAGTQNSPNFCTIFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IAB5</accession>
    <name>Q8IAB5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y110A7A.15</name>
        <name evidence="2 4" type="ORF">Y110A7A.15</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD66207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IAB5"/>
    <dbReference type="PeptideAtlas" id="Q8IAB5"/>
    <dbReference type="UCSC" id="Y110A7A.15a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022462"/>
    <dbReference type="WormBase" id="Y110A7A.15b">
        <property type="protein sequence ID" value="CE33206"/>
        <property type="gene ID" value="WBGene00022462"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030909_0_0_1"/>
    <dbReference type="OrthoDB" id="5870165at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022462">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IAB5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40326">
        <property type="entry name" value="PROTEIN CBG10816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40326:SF1">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD66207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y110A7A.15b"/>
        </source>
    </evidence>
    <sequence length="65" mass="7688" checksum="E2E6679F85819868" modified="2003-03-01" version="1">MSSFHVNSKGQVIILDVNAEQKLHWVKMESIDEIQKWLPPKAERRPTQGFYQANARRGEFKRSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IAB6</accession>
    <name>Q8IAB6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">acdh-1</name>
        <name evidence="12" type="ORF">C55B7.4</name>
        <name evidence="10" type="ORF">CELE_C55B7.4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD68092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367696.1">
        <property type="nucleotide sequence ID" value="NM_001380557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IAB6"/>
    <dbReference type="SMR" id="Q8IAB6"/>
    <dbReference type="IntAct" id="Q8IAB6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q8IAB6"/>
    <dbReference type="GeneID" id="172358"/>
    <dbReference type="KEGG" id="cel:CELE_C55B7.4"/>
    <dbReference type="UCSC" id="C55B7.4b.4">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016943"/>
    <dbReference type="CTD" id="172358"/>
    <dbReference type="WormBase" id="C55B7.4b">
        <property type="protein sequence ID" value="CE32840"/>
        <property type="gene ID" value="WBGene00016943"/>
        <property type="gene designation" value="acdh-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_7_2_1"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016943">
        <property type="expression patterns" value="Expressed in adult organism and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IAB6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000086">
        <property type="entry name" value="Acyl CoA DeHydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000026">
        <property type="entry name" value="Acyl-CoA dehydrogenase medium chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF5">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="71"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="178"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD68092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C55B7.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="Q8IAB6"/>
        </source>
    </evidence>
    <sequence length="252" mass="27562" checksum="F50D17889CB8C22F" modified="2003-03-01" version="1">MGVHVPEEYGGSGSSFFNAMIVIEELAKTDPSVSAMVGIHNTLPVSMIIDYGTEEQKLKYLPRLCSDSLASFCISESGAGSDAFALKTIAKRDGDHFLISGTKMWITNSGEAQVFVVFANADPSQKYKGITCFIVERSADGLTVDKEEDKLGIRASSTCQVHFDNVRVHKSAILGEYGKGYKYAIECLNAGRIAIGAQMIGLAQGCFDQTIPYLQQREQFGQRLIDFQVIFEIGFEFLIHKCSGFTTSDCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IAB7</accession>
    <name>Q8IAB7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAM69 protein-kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C53D5.1</name>
        <name evidence="3" type="ORF">CELE_C53D5.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD67932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367686.1">
        <property type="nucleotide sequence ID" value="NM_001381482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IAB7"/>
    <dbReference type="GeneID" id="171618"/>
    <dbReference type="UCSC" id="C53D5.1c.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016902"/>
    <dbReference type="CTD" id="171618"/>
    <dbReference type="WormBase" id="C53D5.1c">
        <property type="protein sequence ID" value="CE23609"/>
        <property type="gene ID" value="WBGene00016902"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654222_0_0_1"/>
    <dbReference type="OrthoDB" id="8543887at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016902">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IAB7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093:SF2">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004308260" evidence="1">
        <location>
            <begin position="19"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="FAM69 protein-kinase" evidence="2">
        <location>
            <begin position="160"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD67932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C53D5.1c"/>
        </source>
    </evidence>
    <sequence length="355" mass="40796" checksum="07375F6315B4E77A" modified="2003-03-01" version="1">MSIIVLYLIISALTPSESTHKTDLNEPRPGINLTRANQVLTGLCDAYERGDVSGDSCNRLCYDRNWLVTDFYEGHKTVVIVKDGGQIAVYKSTKPFMDQFDEPKDHLTDAEFSDRVVDMVNDELRLGWPKHYRRHLMETVWPTLLRTKGEAMSKADRRSLWALLKQPEFILFRVLPLTRVTPKLIGTCGHMYQTESLVAFKMKGYYTNLKAKILVHVMGTLKLLYEFLDEPLQWCDVRFDNLGLSADYPKRFALMDGDMVYTKSKLDSLLKGRPCESDNDCKIGDCEARCTSNMVCSSRSNGNLEVFCDKLVNKLFANQWSKNNKYLVACRDTGRNITTRLNELRLTWSWNLPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2025-10-08" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IAB8</accession>
    <name>Q8IAB8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="ORF">C09E7.8</name>
        <name evidence="7" type="ORF">CELE_C09E7.8</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63917.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_871695.2">
        <property type="nucleotide sequence ID" value="NM_181966.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IAB8"/>
    <dbReference type="SMR" id="Q8IAB8"/>
    <dbReference type="GeneID" id="175931"/>
    <dbReference type="UCSC" id="C09E7.8a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00015642"/>
    <dbReference type="CTD" id="175931"/>
    <dbReference type="WormBase" id="C09E7.8b">
        <property type="protein sequence ID" value="CE50020"/>
        <property type="gene ID" value="WBGene00015642"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005728_0_0_1"/>
    <dbReference type="OrthoDB" id="5908457at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015642">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IAB8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21447:SF11">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21447">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="755"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="675"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="314"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="419"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD63917.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C09E7.8b"/>
        </source>
    </evidence>
    <sequence length="809" mass="93462" checksum="1B384026FDBB3171" modified="2014-10-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QV6</accession>
    <name>Q95QV6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tiar-1</name>
        <name evidence="5" type="ORF">C18A3.5</name>
        <name evidence="3" type="ORF">CELE_C18A3.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD65017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359874.1">
        <property type="nucleotide sequence ID" value="NM_001373724.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q95QV6"/>
    <dbReference type="PeptideAtlas" id="Q95QV6"/>
    <dbReference type="GeneID" id="173967"/>
    <dbReference type="UCSC" id="C18A3.5f.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00015943"/>
    <dbReference type="CTD" id="173967"/>
    <dbReference type="WormBase" id="C18A3.5c">
        <property type="protein sequence ID" value="CE27710"/>
        <property type="gene ID" value="WBGene00015943"/>
        <property type="gene designation" value="tiar-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2266136_0_0_1"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015943">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q95QV6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:002295">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD65017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C18A3.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q95QV6"/>
        </source>
    </evidence>
    <sequence length="103" mass="11420" checksum="6D3A1877857E5E64" modified="2001-12-01" version="1">MSFFNPPANSNHGYNDDVNTGYNARMHSKLAEREGFHLGNGSDEPRTLYVGNLDSTVTEDFIATLFNQIGSVTKTKVIFDELGYLATNAQGGNQSTPTLRQWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2026-01-28" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QV7</accession>
    <name>Q95QV7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">tiar-1</name>
        <name evidence="6" type="ORF">C18A3.5</name>
        <name evidence="4" type="ORF">CELE_C18A3.5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD65016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_495120.1">
        <property type="nucleotide sequence ID" value="NM_062719.8"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q95QV7"/>
    <dbReference type="SMR" id="Q95QV7"/>
    <dbReference type="PeptideAtlas" id="Q95QV7"/>
    <dbReference type="GeneID" id="173967"/>
    <dbReference type="UCSC" id="C18A3.5f.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00015943"/>
    <dbReference type="CTD" id="173967"/>
    <dbReference type="WormBase" id="C18A3.5b">
        <property type="protein sequence ID" value="CE27709"/>
        <property type="gene ID" value="WBGene00015943"/>
        <property type="gene designation" value="tiar-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015943">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q95QV7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12353">
        <property type="entry name" value="RRM2_TIA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12354">
        <property type="entry name" value="RRM3_TIA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:002295">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000419">
        <property type="entry name" value="CLUMA_CG006354, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000765">
        <property type="entry name" value="RNA-binding protein TIA-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="103"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="209"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD65016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C18A3.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q95QV7"/>
        </source>
    </evidence>
    <sequence length="376" mass="41595" checksum="D717253C85B6818D" modified="2001-12-01" version="1">MSFFNPPANSNHGYNDDVNTGYNARMHSKLAEREGFHLGNGSDEPRTLYVGNLDSTVTEDFIATLFNQIGSVTKTKVIFDEMKVNWAVEPGQQQSKIDTTRHFHVFVGDLSSEVDNQKLREAFQPFGDVSDAKVIRDTNTTKSKGYGFVSYPKREEAERAIEQMNGQWLGRRTIRTNWATRKPGDQEKPSHYNEKSYDEIYNQTSGDNTSVYVGNIASLTEDEIRQGFASFGRITEVRIFKMQGYAFVKFDNKDAAAKAIVQMNNQDVGGQLVRCSWGKTGDTGKTPGGSYGYGYGNSSSGGNSQPYSGYGGGGAYGGGQGGGGHGGPGQQQSNANSQYWQYYAQYYNNPQLMQQWSNYWQQQGGAPQQQNSGGHQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="182" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N2Z7-2</accession>
    <name>WWP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Isoform b of E3 ubiquitin-protein ligase wwp-1</fullName>
            <ecNumber evidence="1">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">wwp-1</name>
        <name evidence="4" type="ORF">Y65B4BR.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Nature" volume="460" first="396" last="399">
            <title>A conserved ubiquitination pathway determines longevity in response to diet restriction.</title>
            <authorList>
                <person name="Carrano A.C."/>
                <person name="Liu Z."/>
                <person name="Dillin A."/>
                <person name="Hunter T."/>
            </authorList>
            <dbReference type="PubMed" id="19553937"/>
            <dbReference type="DOI" id="10.1038/nature08130"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
        <scope>INTERACTION WITH UBC-18</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-762</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2010" name="PLoS ONE" volume="5" first="e9494" last="e9494">
            <title>WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chen C.S."/>
                <person name="Bellier A."/>
                <person name="Kao C.Y."/>
                <person name="Yang Y.L."/>
                <person name="Chen H.D."/>
                <person name="Los F.C."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="20209166"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0009494"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3772" last="3772">
            <title>A Krueppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Carrano A.C."/>
                <person name="Dillin A."/>
                <person name="Hunter T."/>
            </authorList>
            <dbReference type="PubMed" id="24805825"/>
            <dbReference type="DOI" id="10.1038/ncomms4772"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH KLF-1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-762</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9N2Z7-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_061030 VSP_061029"/>
        </isoform>
        <isoform>
            <id>Q9N2Z7-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_061029"/>
        </isoform>
        <isoform>
            <id>Q9N2Z7-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061030"/>
        </isoform>
        <isoform>
            <id>Q9N2Z7-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="1"/>
    <dbReference type="RefSeq" id="NP_740776.1">
        <property type="nucleotide sequence ID" value="NM_171831.4"/>
    </dbReference>
    <dbReference type="WormBase" id="Y65B4BR.4b">
        <property type="protein sequence ID" value="CE31385"/>
        <property type="gene ID" value="WBGene00007009"/>
        <property type="gene designation" value="wwp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.4d"/>
        </source>
    </evidence>
    <sequence length="792" mass="90619" checksum="D28EEDF864BAE1AC" modified="2003-03-01" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="182" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N2Z7-3</accession>
    <name>WWP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Isoform c of E3 ubiquitin-protein ligase wwp-1</fullName>
            <ecNumber evidence="1">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">wwp-1</name>
        <name evidence="4" type="ORF">Y65B4BR.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Nature" volume="460" first="396" last="399">
            <title>A conserved ubiquitination pathway determines longevity in response to diet restriction.</title>
            <authorList>
                <person name="Carrano A.C."/>
                <person name="Liu Z."/>
                <person name="Dillin A."/>
                <person name="Hunter T."/>
            </authorList>
            <dbReference type="PubMed" id="19553937"/>
            <dbReference type="DOI" id="10.1038/nature08130"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
        <scope>INTERACTION WITH UBC-18</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-762</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2010" name="PLoS ONE" volume="5" first="e9494" last="e9494">
            <title>WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chen C.S."/>
                <person name="Bellier A."/>
                <person name="Kao C.Y."/>
                <person name="Yang Y.L."/>
                <person name="Chen H.D."/>
                <person name="Los F.C."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="20209166"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0009494"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3772" last="3772">
            <title>A Krueppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Carrano A.C."/>
                <person name="Dillin A."/>
                <person name="Hunter T."/>
            </authorList>
            <dbReference type="PubMed" id="24805825"/>
            <dbReference type="DOI" id="10.1038/ncomms4772"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH KLF-1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-762</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9N2Z7-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9N2Z7-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061030"/>
        </isoform>
        <isoform>
            <id>Q9N2Z7-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_061030 VSP_061029"/>
        </isoform>
        <isoform>
            <id>Q9N2Z7-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_061029"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001293271.1">
        <property type="nucleotide sequence ID" value="NM_001306342.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y65B4BR.4c">
        <property type="protein sequence ID" value="CE49230"/>
        <property type="gene ID" value="WBGene00007009"/>
        <property type="gene designation" value="wwp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.4d"/>
        </source>
    </evidence>
    <sequence length="507" mass="59928" checksum="2BA7AD6A84050E79" modified="2003-03-01" version="2">MLEAHEQWQSGRDQAMLQWEQRFLLQQNNFSADDPLGPLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGFRGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDPRTGKPVGPLGVVGVQMAMEKSFRWKIAQFRYLCLSNSVPNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPASFVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRHYAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGFGNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-06-02" modified="2026-01-28" version="182" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N2Z7-4</accession>
    <name>WWP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Isoform d of E3 ubiquitin-protein ligase wwp-1</fullName>
            <ecNumber evidence="1">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">wwp-1</name>
        <name evidence="4" type="ORF">Y65B4BR.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Nature" volume="460" first="396" last="399">
            <title>A conserved ubiquitination pathway determines longevity in response to diet restriction.</title>
            <authorList>
                <person name="Carrano A.C."/>
                <person name="Liu Z."/>
                <person name="Dillin A."/>
                <person name="Hunter T."/>
            </authorList>
            <dbReference type="PubMed" id="19553937"/>
            <dbReference type="DOI" id="10.1038/nature08130"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
        <scope>INTERACTION WITH UBC-18</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-762</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2010" name="PLoS ONE" volume="5" first="e9494" last="e9494">
            <title>WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chen C.S."/>
                <person name="Bellier A."/>
                <person name="Kao C.Y."/>
                <person name="Yang Y.L."/>
                <person name="Chen H.D."/>
                <person name="Los F.C."/>
                <person name="Aroian R.V."/>
            </authorList>
            <dbReference type="PubMed" id="20209166"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0009494"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3772" last="3772">
            <title>A Krueppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Carrano A.C."/>
                <person name="Dillin A."/>
                <person name="Hunter T."/>
            </authorList>
            <dbReference type="PubMed" id="24805825"/>
            <dbReference type="DOI" id="10.1038/ncomms4772"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH KLF-1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-762</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9N2Z7-4</id>
            <name evidence="7">d</name>
            <sequence type="described" ref="VSP_061030 VSP_061029"/>
        </isoform>
        <isoform>
            <id>Q9N2Z7-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061030"/>
        </isoform>
        <isoform>
            <id>Q9N2Z7-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9N2Z7-3</id>
            <name evidence="6">c</name>
            <sequence type="described" ref="VSP_061029"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001293272.1">
        <property type="nucleotide sequence ID" value="NM_001306343.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y65B4BR.4d">
        <property type="protein sequence ID" value="CE49306"/>
        <property type="gene ID" value="WBGene00007009"/>
        <property type="gene designation" value="wwp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y65B4BR.4d"/>
        </source>
    </evidence>
    <sequence length="505" mass="59625" checksum="6C9E9D9E6126EDE0" modified="2003-03-01" version="2">MLEAHEQWQSGRDQAMLQWEQRFLLQQNNFSADDPLGPLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDPRTGKPVGPLGVVGVQMAMEKSFRWKIAQFRYLCLSNSVPNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPASFVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRHYAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGFGNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N4G4-2</accession>
    <name>MED1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Mediator of RNA polymerase II transcription subunit 1.1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 1.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Suppressor of pal-1 protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sop-3</name>
        <name type="synonym">mdt-1.1</name>
        <name type="ORF">Y71F9B.10</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Development" volume="128" first="767" last="777">
            <title>The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression.</title>
            <authorList>
                <person name="Zhang H."/>
                <person name="Emmons S.W."/>
            </authorList>
            <dbReference type="PubMed" id="11171401"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9N4G4-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_027909 VSP_027908"/>
        </isoform>
        <isoform>
            <id>Q9N4G4-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="WormBase" id="Y71F9B.10b">
        <property type="protein sequence ID" value="CE29912"/>
        <property type="gene ID" value="WBGene00004946"/>
        <property type="gene designation" value="sop-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="544" mass="61840" checksum="478ADA6030DDA18D" modified="2001-10-01" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2026-01-28" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XTG1-2</accession>
    <name>NLGN1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Neuroligin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nlg-1</name>
        <name type="ORF">C40C9.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="667" last="672">
            <title>Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Saito H."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Hirabayashi J."/>
                <person name="Kasai K."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="12754521"/>
            <dbReference type="DOI" id="10.1038/nbt829"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-315</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-315</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2015" name="Neuron" volume="86" first="1407" last="1419">
            <title>C. elegans Punctin Clusters GABA(A) Receptors via Neuroligin Binding and UNC-40/DCC Recruitment.</title>
            <authorList>
                <person name="Tu H."/>
                <person name="Pinan-Lucarre B."/>
                <person name="Ji T."/>
                <person name="Jospin M."/>
                <person name="Bessereau J.L."/>
            </authorList>
            <dbReference type="PubMed" id="26028575"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2015.05.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MADD-4 AND UNC-49</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF 786-THR--VAL-798</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2015" name="Neuron" volume="86" first="1420" last="1432">
            <title>MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin.</title>
            <authorList>
                <person name="Maro G.S."/>
                <person name="Gao S."/>
                <person name="Olechwier A.M."/>
                <person name="Hung W.L."/>
                <person name="Liu M."/>
                <person name="Oezkan E."/>
                <person name="Zhen M."/>
                <person name="Shen K."/>
            </authorList>
            <dbReference type="PubMed" id="26028574"/>
            <dbReference type="DOI" id="10.1016/j.neuron.2015.05.015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MADD-4</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF 796-ILE--VAL-798</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9XTG1-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020296"/>
        </isoform>
        <isoform>
            <id>Q9XTG1-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_872254.1">
        <property type="nucleotide sequence ID" value="NM_182454.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C40C9.5b">
        <property type="protein sequence ID" value="CE32604"/>
        <property type="gene ID" value="WBGene00006412"/>
        <property type="gene designation" value="nlg-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="795" mass="88760" checksum="1F934CE623B0E14E" modified="1999-11-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXC7</accession>
    <name>Q9XXC7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein lilliputian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">spat-2</name>
        <name evidence="2" type="ORF">CELE_Y48A6B.13</name>
        <name evidence="4" type="ORF">Y48A6B.13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAA19534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T26987">
        <property type="entry name" value="T26987"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001366652.1">
        <property type="nucleotide sequence ID" value="NM_001379926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XXC7"/>
    <dbReference type="SMR" id="Q9XXC7"/>
    <dbReference type="PeptideAtlas" id="Q9XXC7"/>
    <dbReference type="GeneID" id="3564779"/>
    <dbReference type="UCSC" id="Y48A6B.13.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012973"/>
    <dbReference type="CTD" id="3564779"/>
    <dbReference type="WormBase" id="Y48A6B.13c">
        <property type="protein sequence ID" value="CE19195"/>
        <property type="gene ID" value="WBGene00012973"/>
        <property type="gene designation" value="spat-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038412_0_0_1"/>
    <dbReference type="OrthoDB" id="5845256at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012973">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XXC7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y48A6B.13c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XXC7"/>
        </source>
    </evidence>
    <sequence length="396" mass="42616" checksum="0013594F5F03ADBF" modified="1999-11-01" version="1">MDEVAVAASITKRSSSGAAQQSEEDDDQSYVSAQENLGGSNSRLSTPPTEFADARQSRDEAIENVMADPNNYRDDDDVETLAKQLQQEEDEFITVGKNRKKNKKQSSVQDNGSSSSSASSSASPSNRRNTLPDARASSAIGYASSSSTATPATPQSQQQQHFQRNRPAAHSTTLADFIDSTKKETHKNVKHKKISAGAGAHHKKHESMEEPVFLDAPETISVNTAPGFSYADAAKKTSGENSPEMSPIPPPPPASTASAEPIVEKKPLREGSSGGAVQLPPSTLAASDISFGYEETPEDKRKRLQKESKSVTSPPPPTQKAPPPPPTRMNGDDLLRSFTTQDGNGGNRLAGLQEMPKTWSSESNVLGTEILANWKPQWEKFMNTGAKPITFVPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="179" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXH4</accession>
    <name>Q9XXH4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ash-2</name>
        <name evidence="8" type="ORF">CELE_Y17G7B.2</name>
        <name evidence="10" type="ORF">Y17G7B.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAA19468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T26514">
        <property type="entry name" value="T26514"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359515.1">
        <property type="nucleotide sequence ID" value="NM_001373799.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XXH4"/>
    <dbReference type="SMR" id="Q9XXH4"/>
    <dbReference type="IntAct" id="Q9XXH4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="174838"/>
    <dbReference type="UCSC" id="Y17G7B.2b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012458"/>
    <dbReference type="CTD" id="174838"/>
    <dbReference type="WormBase" id="Y17G7B.2b">
        <property type="protein sequence ID" value="CE20199"/>
        <property type="gene ID" value="WBGene00012458"/>
        <property type="gene designation" value="ash-2"/>
    </dbReference>
    <dbReference type="OMA" id="CATCSRW"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="PhylomeDB" id="Q9XXH4"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012458">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XXH4">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060290">
        <property type="term" value="P:transdifferentiation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd15583">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049455">
        <property type="entry name" value="ASH2-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053835">
        <property type="entry name" value="ASH2L-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21198">
        <property type="entry name" value="ASH2L-like_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21257">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="272"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA19468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y17G7B.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XXH4"/>
        </source>
    </evidence>
    <sequence length="572" mass="64773" checksum="D4EDA58F588BE934" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AQM5</accession>
    <name>A0A0K3AQM5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pre-mRNA-splicing factor SLU7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_K07A12.5</name>
        <name evidence="1 3" type="ORF">K07A12.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300400.1">
        <property type="nucleotide sequence ID" value="NM_001313471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AQM5"/>
    <dbReference type="SMR" id="A0A0K3AQM5"/>
    <dbReference type="GeneID" id="187086"/>
    <dbReference type="AGR" id="WB:WBGene00010623"/>
    <dbReference type="CTD" id="187086"/>
    <dbReference type="WormBase" id="K07A12.5c">
        <property type="protein sequence ID" value="CE25934"/>
        <property type="gene ID" value="WBGene00010623"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5798077at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010623">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AQM5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CTQ86339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="K07A12.5c"/>
        </source>
    </evidence>
    <sequence length="307" mass="34935" checksum="7D1925CBF8892445" modified="2015-11-11" version="1">MQRANTVVNRQGVKVDVEFGRLKEYYLSTLAPQKKFVSIRDHAAREKELDALRKKQKISLEQRKDKQDNIKKSQAEYDQMKSLYAAPVDPKQTKVETMEQKEVLEPTAPMEKFVVNTTDDKRALFPASWYQQPISRSQLKKGKMIYWMAKDEEEDMTLDDDPEGKYTVTAEKLIETMTAGGKVKHAGITEPPSNTANTIMSESLASINARYKKSCERNAVFMNTLHGTIEFNKKQVSVDKTLSTSSISQDDATDAPNQIIFAPTITSHVFKGRSLKRQYAVKNKALETFEEDRKDYTREAGEETSGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AXH1-2</accession>
    <name>ARID1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform a of AT-rich interactive domain-containing protein arid-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arid-1</name>
        <name evidence="4" type="ORF">Y108G3AL.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2018" name="Genetics" volume="210" first="1329" last="1337">
            <title>Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tillman E.J."/>
                <person name="Richardson C.E."/>
                <person name="Cattie D.J."/>
                <person name="Reddy K.C."/>
                <person name="Lehrbach N.J."/>
                <person name="Droste R."/>
                <person name="Ruvkun G."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30287474"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301450"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A0K3AXH1-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_061277"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_061281 VSP_061278"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_061280 VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_061278"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_061279"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-6</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_061279 VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_061280"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001041181.2">
        <property type="nucleotide sequence ID" value="NM_001047716.4"/>
    </dbReference>
    <dbReference type="WormBase" id="Y108G3AL.7a">
        <property type="protein sequence ID" value="CE45961"/>
        <property type="gene ID" value="WBGene00044689"/>
        <property type="gene designation" value="arid-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
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    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7g"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="Y108G3AL.7h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7i"/>
        </source>
    </evidence>
    <sequence length="1645" mass="185194" checksum="9768A133C8386E01" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AXH1-3</accession>
    <name>ARID1_CAEEL</name>
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        <recommendedName>
            <fullName evidence="4">Isoform c of AT-rich interactive domain-containing protein arid-1</fullName>
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    <gene>
        <name evidence="4" type="primary">arid-1</name>
        <name evidence="4" type="ORF">Y108G3AL.7</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2018" name="Genetics" volume="210" first="1329" last="1337">
            <title>Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tillman E.J."/>
                <person name="Richardson C.E."/>
                <person name="Cattie D.J."/>
                <person name="Reddy K.C."/>
                <person name="Lehrbach N.J."/>
                <person name="Droste R."/>
                <person name="Ruvkun G."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30287474"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301450"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A0K3AXH1-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_061281 VSP_061278"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_061278"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_061280 VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-6</id>
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            <sequence type="described" ref="VSP_061279 VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_061277"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-5</id>
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        </isoform>
        <isoform>
            <id>A0A0K3AXH1-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_061280"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001300005.1">
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    </dbReference>
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        <property type="gene ID" value="WBGene00044689"/>
        <property type="gene designation" value="arid-1"/>
    </dbReference>
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        <property type="component" value="Chromosome V"/>
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    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7f"/>
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    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7h"/>
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    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7i"/>
        </source>
    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AXH1-4</accession>
    <name>ARID1_CAEEL</name>
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        <recommendedName>
            <fullName evidence="4">Isoform d of AT-rich interactive domain-containing protein arid-1</fullName>
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    <gene>
        <name evidence="4" type="primary">arid-1</name>
        <name evidence="4" type="ORF">Y108G3AL.7</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2018" name="Genetics" volume="210" first="1329" last="1337">
            <title>Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tillman E.J."/>
                <person name="Richardson C.E."/>
                <person name="Cattie D.J."/>
                <person name="Reddy K.C."/>
                <person name="Lehrbach N.J."/>
                <person name="Droste R."/>
                <person name="Ruvkun G."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30287474"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301450"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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            <id>A0A0K3AXH1-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_061281 VSP_061278"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-6</id>
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            <sequence type="described" ref="VSP_061281 VSP_061279"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-5</id>
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            <sequence type="described" ref="VSP_061279"/>
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            <id>A0A0K3AXH1-7</id>
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        </isoform>
        <isoform>
            <id>A0A0K3AXH1-4</id>
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    </comment>
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    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7c"/>
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    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7d"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="Y108G3AL.7h"/>
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    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7i"/>
        </source>
    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AXH1-5</accession>
    <name>ARID1_CAEEL</name>
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        <recommendedName>
            <fullName evidence="4">Isoform e of AT-rich interactive domain-containing protein arid-1</fullName>
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        <name evidence="4" type="primary">arid-1</name>
        <name evidence="4" type="ORF">Y108G3AL.7</name>
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    <organism>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
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    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2018" name="Genetics" volume="210" first="1329" last="1337">
            <title>Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.</title>
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                <person name="Richardson C.E."/>
                <person name="Cattie D.J."/>
                <person name="Reddy K.C."/>
                <person name="Lehrbach N.J."/>
                <person name="Droste R."/>
                <person name="Ruvkun G."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30287474"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301450"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
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        <event type="alternative splicing"/>
        <isoform>
            <id>A0A0K3AXH1-7</id>
            <name evidence="9">g</name>
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        </isoform>
        <isoform>
            <id>A0A0K3AXH1-6</id>
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            <sequence type="described" ref="VSP_061279 VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-5</id>
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        </isoform>
        <isoform>
            <id>A0A0K3AXH1-1</id>
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            <id>A0A0K3AXH1-9</id>
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        </isoform>
        <isoform>
            <id>A0A0K3AXH1-8</id>
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            <id>A0A0K3AXH1-3</id>
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        <isoform>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
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    <evidence type="ECO:0000312" key="4">
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    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7h"/>
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    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7i"/>
        </source>
    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AXH1-6</accession>
    <name>ARID1_CAEEL</name>
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        <recommendedName>
            <fullName evidence="4">Isoform f of AT-rich interactive domain-containing protein arid-1</fullName>
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        <name evidence="4" type="primary">arid-1</name>
        <name evidence="4" type="ORF">Y108G3AL.7</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2018" name="Genetics" volume="210" first="1329" last="1337">
            <title>Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tillman E.J."/>
                <person name="Richardson C.E."/>
                <person name="Cattie D.J."/>
                <person name="Reddy K.C."/>
                <person name="Lehrbach N.J."/>
                <person name="Droste R."/>
                <person name="Ruvkun G."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30287474"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301450"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A0K3AXH1-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_061278"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_061280"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_061280 VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_061277"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_061279"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_061278 VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-6</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_061281 VSP_061279"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001300008.1">
        <property type="nucleotide sequence ID" value="NM_001313079.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y108G3AL.7f">
        <property type="protein sequence ID" value="CE50718"/>
        <property type="gene ID" value="WBGene00044689"/>
        <property type="gene designation" value="arid-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7i"/>
        </source>
    </evidence>
    <sequence length="982" mass="107899" checksum="42919BE339BCF31E" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AXH1-7</accession>
    <name>ARID1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform g of AT-rich interactive domain-containing protein arid-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arid-1</name>
        <name evidence="4" type="ORF">Y108G3AL.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2018" name="Genetics" volume="210" first="1329" last="1337">
            <title>Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tillman E.J."/>
                <person name="Richardson C.E."/>
                <person name="Cattie D.J."/>
                <person name="Reddy K.C."/>
                <person name="Lehrbach N.J."/>
                <person name="Droste R."/>
                <person name="Ruvkun G."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30287474"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301450"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A0K3AXH1-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_061280 VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_061280"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_061278"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_061281 VSP_061278"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-6</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_061281 VSP_061279"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_061279"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_061277"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001300009.1">
        <property type="nucleotide sequence ID" value="NM_001313080.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y108G3AL.7g">
        <property type="protein sequence ID" value="CE50883"/>
        <property type="gene ID" value="WBGene00044689"/>
        <property type="gene designation" value="arid-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7i"/>
        </source>
    </evidence>
    <sequence length="410" mass="44277" checksum="016D831A4CFD1BF6" modified="2015-11-11" version="1">MASPMFSPNSDLSLSGPLTLPRSGPLTMANIRQSPTPDEVVGSLRKRLSQTSESSESSELPPPPSAASKSKRIRRASERSIDSASEHHRMMRSPRILTTQHSSGALIFDISTTQPTDTSGPIEALSVRKPGRRKTVFAASPTLLTSGPLTLSSSAPPPPPASPAPPQHAQKTLGRPRKTPSTSSRKPEEEDEAEQIPTTVVGVTEEASVADSSAKEDLTSEDGSATPQDEKDDSESTTTTDTITPKSIRGGKRRRGGGRFGGSYPVKPAKPGRKPKDPHAEEGADEKDPEDQTPTTMTTSTPTRADSFQTQKNRMAKLMEGKPHDYSFLDLPDFDKIIEEAPKEDINILMEERTYELREIFAQCKADLSALEKRYRQQNEAKRKAEFAAKTASSAAAAQASSSTCSTPRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AXH1-8</accession>
    <name>ARID1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform h of AT-rich interactive domain-containing protein arid-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arid-1</name>
        <name evidence="4" type="ORF">Y108G3AL.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2018" name="Genetics" volume="210" first="1329" last="1337">
            <title>Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tillman E.J."/>
                <person name="Richardson C.E."/>
                <person name="Cattie D.J."/>
                <person name="Reddy K.C."/>
                <person name="Lehrbach N.J."/>
                <person name="Droste R."/>
                <person name="Ruvkun G."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30287474"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301450"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A0K3AXH1-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-6</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_061279 VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_061280"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_061278 VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_061277"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_061278"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_061281 VSP_061280"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_061279"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001300010.1">
        <property type="nucleotide sequence ID" value="NM_001313081.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y108G3AL.7h">
        <property type="protein sequence ID" value="CE50807"/>
        <property type="gene ID" value="WBGene00044689"/>
        <property type="gene designation" value="arid-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7i"/>
        </source>
    </evidence>
    <sequence length="407" mass="43960" checksum="1A0157E7481F70F6" modified="2015-11-11" version="1">MASPMFSPNSDLSLSGPLTLPRSGPLTMANIRQSPTPDEVVGSLRKRLSQTSESSESSELPPPPSAASKSKRIRRASERSIDSASEHHRMMRSPRILTTQHSSGALIFDISTTQPTDTSGPIEALSVRKPGRRKTASPTLLTSGPLTLSSSAPPPPPASPAPPQHAQKTLGRPRKTPSTSSRKPEEEDEAEQIPTTVVGVTEEASVADSSAKEDLTSEDGSATPQDEKDDSESTTTTDTITPKSIRGGKRRRGGGRFGGSYPVKPAKPGRKPKDPHAEEGADEKDPEDQTPTTMTTSTPTRADSFQTQKNRMAKLMEGKPHDYSFLDLPDFDKIIEEAPKEDINILMEERTYELREIFAQCKADLSALEKRYRQQNEAKRKAEFAAKTASSAAAAQASSSTCSTPRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AXH1-9</accession>
    <name>ARID1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform i of AT-rich interactive domain-containing protein arid-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arid-1</name>
        <name evidence="4" type="ORF">Y108G3AL.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2018" name="Genetics" volume="210" first="1329" last="1337">
            <title>Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Tillman E.J."/>
                <person name="Richardson C.E."/>
                <person name="Cattie D.J."/>
                <person name="Reddy K.C."/>
                <person name="Lehrbach N.J."/>
                <person name="Droste R."/>
                <person name="Ruvkun G."/>
                <person name="Kim D.H."/>
            </authorList>
            <dbReference type="PubMed" id="30287474"/>
            <dbReference type="DOI" id="10.1534/genetics.118.301450"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A0K3AXH1-3</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_061280"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-6</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_061279 VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-4</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_061280 VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-7</id>
            <name evidence="9">g</name>
            <sequence type="described" ref="VSP_061278"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061281"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_061277"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-5</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_061279"/>
        </isoform>
        <isoform>
            <id>A0A0K3AXH1-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_061281 VSP_061278"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001300218.1">
        <property type="nucleotide sequence ID" value="NM_001313289.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y108G3AL.7i">
        <property type="protein sequence ID" value="CE35266"/>
        <property type="gene ID" value="WBGene00044689"/>
        <property type="gene designation" value="arid-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="Y108G3AL.7i"/>
        </source>
    </evidence>
    <sequence length="114" mass="12895" checksum="FC31FB13701FB1EC" modified="2015-11-11" version="1">MTTSTPTRADSFQTQKNRMAKLMEGKPHDYSFLDLPDFDKIIEEAPKEDINILMEERTYELREIFAQCKADLSALEKRYRQQNEAKRKAEFAAKTASSAAAAQASSSTCSTPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-02-17" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0U1RML6</accession>
    <name>A0A0U1RML6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">sago-2</name>
        <name evidence="6" type="ORF">CELE_F56A6.1</name>
        <name evidence="8" type="ORF">F56A6.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD71916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379987.1">
        <property type="nucleotide sequence ID" value="NM_001392310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0U1RML6"/>
    <dbReference type="SMR" id="A0A0U1RML6"/>
    <dbReference type="GeneID" id="171653"/>
    <dbReference type="KEGG" id="cel:CELE_F56A6.1"/>
    <dbReference type="AGR" id="WB:WBGene00018921"/>
    <dbReference type="CTD" id="171653"/>
    <dbReference type="WormBase" id="F56A6.1b">
        <property type="protein sequence ID" value="CE33401"/>
        <property type="gene ID" value="WBGene00018921"/>
        <property type="gene designation" value="sago-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9981668at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018921">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0U1RML6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02826">
        <property type="entry name" value="Piwi-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057272">
        <property type="entry name" value="Piwi_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="4">
        <location>
            <begin position="273"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="5">
        <location>
            <begin position="549"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD71916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F56A6.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0U1RML6"/>
        </source>
    </evidence>
    <sequence length="856" mass="96129" checksum="37A126D9398C4CFD" modified="2016-02-17" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H5N7</accession>
    <name>A0A168H5N7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear Hormone Receptor family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nhr-188</name>
        <name evidence="13" type="ORF">CELE_F47C10.7</name>
        <name evidence="15" type="ORF">F47C10.7</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317819.1">
        <property type="nucleotide sequence ID" value="NM_001330816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H5N7"/>
    <dbReference type="SMR" id="A0A168H5N7"/>
    <dbReference type="GeneID" id="185912"/>
    <dbReference type="KEGG" id="cel:CELE_F47C10.7"/>
    <dbReference type="AGR" id="WB:WBGene00018544"/>
    <dbReference type="CTD" id="185912"/>
    <dbReference type="WormBase" id="F47C10.7b">
        <property type="protein sequence ID" value="CE51570"/>
        <property type="gene ID" value="WBGene00018544"/>
        <property type="gene designation" value="nhr-188"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018779at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018544">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A168H5N7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45886:SF16">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45886">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="110"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SAP35579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F47C10.7b"/>
        </source>
    </evidence>
    <sequence length="312" mass="35780" checksum="E73642B4584EE9F4" modified="2016-07-06" version="1">MKVFKTLLSMDRSTLKCLICGRNASCHNYGVLTCNACKMFFRRVVIEQITYQCRNWKKCLENADQFKPRCKACRFEKCVRLGMKLGPIAMEKLYKTKPMSHPDFATNALIQEVLYLNYTKRYKLCNFYTSENPTLEEMVQTTFWSGMKRKTEKQEISVAEWSFQATYIAVETFLSLEFMNLIENDEKVVLLRNFSSKSIVLDSAMRALNAKVDRVTTPDGEDIYSDIILSMFSAGFLNSIQCGLVSRVAELKVTELEHAMLSVLLFCNPDLLSISHVINKTSEDANSLTTLCQLYFPKSKLKHLLIDTCINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H5R9</accession>
    <name>A0A168H5R9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srt-20</name>
        <name evidence="2" type="ORF">CELE_F47D2.7</name>
        <name evidence="4" type="ORF">F47D2.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317820.1">
        <property type="nucleotide sequence ID" value="NM_001330847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H5R9"/>
    <dbReference type="SMR" id="A0A168H5R9"/>
    <dbReference type="GeneID" id="185928"/>
    <dbReference type="KEGG" id="cel:CELE_F47D2.7"/>
    <dbReference type="AGR" id="WB:WBGene00018558"/>
    <dbReference type="CTD" id="185928"/>
    <dbReference type="WormBase" id="F47D2.7b">
        <property type="protein sequence ID" value="CE51559"/>
        <property type="gene ID" value="WBGene00018558"/>
        <property type="gene designation" value="srt-20"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5791147at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF16">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SAP35580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F47D2.7b"/>
        </source>
    </evidence>
    <sequence length="334" mass="37655" checksum="A69EA674D0A7F174" modified="2016-07-06" version="1">MVLDKIIPDFNLTLTNMVLNGLELDPNYYGCPEEIHKRPPSVPRPYWGMWFLGSGIVMLMLYIPCFFAIVTSPLLKSPAYKTMLVLAIYDISSIFIHSISTGILGFFGVPFCDYPRLIATLGGVALGSWMGCCIASMTLAVIRICDLSMQMNIKKCFAGNKIYFFLFSFFVYGVGAGILTKPVIFTPTHMSWFFDPMVGKNPEFYVNLPHTYNNIIMAICTIVFYGFLSYLAFRTADPNAQRSSSRKILLQSFFFCIFHTIASVLYAYMQFIAAPPFLILVSQIAWQISSGSVCIVYLTLNKTIRTSVMKMVCPKSYLYGRRISIMLSMNSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A168H612</accession>
    <name>A0A168H612_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF7153 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_H10D18.5</name>
        <name evidence="3 5" type="ORF">H10D18.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SAP35585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317825.1">
        <property type="nucleotide sequence ID" value="NM_001330814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H612"/>
    <dbReference type="GeneID" id="186716"/>
    <dbReference type="AGR" id="WB:WBGene00019180"/>
    <dbReference type="CTD" id="186716"/>
    <dbReference type="WormBase" id="H10D18.5c">
        <property type="protein sequence ID" value="CE51673"/>
        <property type="gene ID" value="WBGene00019180"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6060890at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019180">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A168H612">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055577">
        <property type="entry name" value="DUF7153"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22198">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22198:SF1">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23672">
        <property type="entry name" value="DUF7153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7153" evidence="2">
        <location>
            <begin position="84"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SAP35585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="H10D18.5c"/>
        </source>
    </evidence>
    <sequence length="351" mass="40252" checksum="202D8CF31BC450EA" modified="2016-07-06" version="1">MNMVRNHVAYHRTSLRSPTTINSYSVKSEEVIDVSEGEMSEVSSLIGFVGGPRDPGCSYGFAQEDPAYEKAVSECHVIQEKKDFAEAVLLKCIDNKPLFPYMHFAQFRNVDYTHRVKQISDLARECSPTHGSLYGCYDEVYSIQKTASVGEYRLPAHRHSGYIVIGFKLLEDAGKQGNLEKTWLQWSGAREIYKHSPRSWNLRRISLMRCPTHHKNGVAQRPFAYILMCEYGSILHPSNTIQALDICERLRVRNCGHIALYQVHSAYTSPGPRTSAHNSPSRQASAFAQSAATKRAQMLRGFSQDVEPQPIQESSTLRRNRMLRTRERSFQYPDEYYHAYQPHQFDTQEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSR3</accession>
    <name>A0A1C3NSR3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Inward rectifier potassium channel irk-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">irk-2</name>
        <name evidence="16" type="ORF">CELE_M02A10.2</name>
        <name evidence="18" type="ORF">M02A10.2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="SBV53400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317907.1">
        <property type="nucleotide sequence ID" value="NM_001330888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSR3"/>
    <dbReference type="SMR" id="A0A1C3NSR3"/>
    <dbReference type="GeneID" id="191695"/>
    <dbReference type="AGR" id="WB:WBGene00002150"/>
    <dbReference type="CTD" id="191695"/>
    <dbReference type="WormBase" id="M02A10.2f">
        <property type="protein sequence ID" value="CE51721"/>
        <property type="gene ID" value="WBGene00002150"/>
        <property type="gene designation" value="irk-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002150">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSR3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000230">
        <property type="entry name" value="Inward Rectifying K (Potassium) channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="66"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="213"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SBV53400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="M02A10.2f"/>
        </source>
    </evidence>
    <sequence length="494" mass="56837" checksum="B0A6C0961188BD3C" modified="2016-11-02" version="1">MPQNFVERVERLALANGRLPGRSLLLDREQAQRMLDIEEPLVKNKKYPFFKTPRLGGSRRIRNRLVQKQGLCNISLKNVPKQRRKYFSDIFTTVIEMKWRWCLLYFSLSFMISWSFFATVYFLIAKQHGDIEQIANATWTPCIVNVHNELNAFLFSFTTQTTIGYGFRYPTDACPLTIVTMCFQFMWGVMTQTLMAGIIFSKLARPIKRAATLIFSKNAVICLRDGKLCLLFRVGDMRKSSLAEAHVRLQMIKRCVTYEGELLPFHQFDMDVGYDQGLDRVFVIWPITICHEIDERSPLWEIGADDLKSAKFEIIAILEGVVESVGSTTQARTSYLPSEILWGHRFEKLVHYKKENGQYNIDFGKFHNVYSVNTPTCSAAEIERLRSEGIFNESEYQMYPPSDNKLNLLDNDEMSPVRDSIDLNQIQILRRDSDEDPDAGEESMELVDLGIHHKCSIRSQSPIINSTSHLLQPMHKNSCSVRRGSSTLNVSLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSR4</accession>
    <name>A0A1C3NSR4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">IRK_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">irk-3</name>
        <name evidence="15" type="ORF">CELE_K04G11.5</name>
        <name evidence="17" type="ORF">K04G11.5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="SBV53386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317893.1">
        <property type="nucleotide sequence ID" value="NM_001330918.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSR4"/>
    <dbReference type="SMR" id="A0A1C3NSR4"/>
    <dbReference type="GeneID" id="191696"/>
    <dbReference type="KEGG" id="cel:CELE_K04G11.5"/>
    <dbReference type="AGR" id="WB:WBGene00002151"/>
    <dbReference type="CTD" id="191696"/>
    <dbReference type="WormBase" id="K04G11.5b">
        <property type="protein sequence ID" value="CE51706"/>
        <property type="gene ID" value="WBGene00002151"/>
        <property type="gene designation" value="irk-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002151">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSR4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000007">
        <property type="entry name" value="Inward Rectifying K (Potassium) channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF61">
        <property type="entry name" value="IRK_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="13">
        <location>
            <begin position="50"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="14">
        <location>
            <begin position="191"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SBV53386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="K04G11.5b"/>
        </source>
    </evidence>
    <sequence length="379" mass="43682" checksum="EC03BC6ADC03CE9B" modified="2016-11-02" version="1">MCMMKTVTTSMSLAEELERLSGENGAKKELNGWRLSSSAPELGVQRARLVSKDGKTLLNNIQIPERFRQAYKNWFHLIIECNWRTICILFLLGFIVSWTIFAVIYYVISRLKTVKKDESCIANVDTLISAFLFSMESQHTIGYGLRYMTDLCPPAYLTLCVQCVVGVFLQTILAGIVIAKILRPKKRRQEMRFSRMAVIGPLDEHDKRPTLMIRLADIQEKLFLAESHVRLYMACSKINSRGDRELIGVKDMNVGYDSGWDRVLLLWPIIVRHVINEDSPLYGMSRENIVKADFELIMTVEGIVEATGMTFQARTSFLPDEILWGYKFKPMVLMNEKLSKYEVHYSFFDQTERVCDFDAQTIETEETEDEHHHNASGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C3NSS7</accession>
    <name>A0A1C3NSS7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">IRK_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">irk-3</name>
        <name evidence="15" type="ORF">CELE_K04G11.5</name>
        <name evidence="17" type="ORF">K04G11.5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="SBV53396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001317903.1">
        <property type="nucleotide sequence ID" value="NM_001330920.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C3NSS7"/>
    <dbReference type="SMR" id="A0A1C3NSS7"/>
    <dbReference type="GeneID" id="191696"/>
    <dbReference type="AGR" id="WB:WBGene00002151"/>
    <dbReference type="CTD" id="191696"/>
    <dbReference type="WormBase" id="K04G11.5d">
        <property type="protein sequence ID" value="CE51731"/>
        <property type="gene ID" value="WBGene00002151"/>
        <property type="gene designation" value="irk-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002151">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A1C3NSS7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000007">
        <property type="entry name" value="Inward Rectifying K (Potassium) channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF61">
        <property type="entry name" value="IRK_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="13">
        <location>
            <begin position="40"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="14">
        <location>
            <begin position="181"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SBV53396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="K04G11.5d"/>
        </source>
    </evidence>
    <sequence length="369" mass="42567" checksum="E7439F57369E594A" modified="2016-11-02" version="1">MSLAEELERLSGENGAKKELNGWRLSSSAPELGVQRARLVSKDGKTLLNNIQIPERFRQAYKNWFHLIIECNWRTICILFLLGFIVSWTIFAVIYYVISRLKTVKKDESCIANVDTLISAFLFSMESQHTIGYGLRYMTDLCPPAYLTLCVQCVVGVFLQTILAGIVIAKILRPKKRRQEMRFSRMAVIGPLDEHDKRPTLMIRLADIQEKLFLAESHVRLYMACSKINSRGDRELIGVKDMNVGYDSGWDRVLLLWPIIVRHVINEDSPLYGMSRENIVKADFELIMTVEGIVEATGMTFQARTSFLPDEILWGYKFKPMVLMNEKLSKYEVHYSFFDQTERVCDFDAQTIETEETEDEHHHNASGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3I4</accession>
    <name>A0A2C9C3I4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Ryanodine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">unc-68</name>
        <name evidence="20" type="ORF">CELE_K11C4.5</name>
        <name evidence="22" type="ORF">K11C4.5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343813.1">
        <property type="nucleotide sequence ID" value="NM_001356683.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2C9C3I4"/>
    <dbReference type="GeneID" id="179080"/>
    <dbReference type="AGR" id="WB:WBGene00006801"/>
    <dbReference type="CTD" id="179080"/>
    <dbReference type="WormBase" id="K11C4.5j">
        <property type="protein sequence ID" value="CE52247"/>
        <property type="gene ID" value="WBGene00006801"/>
        <property type="gene designation" value="unc-68"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300855at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006801">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3I4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23278">
        <property type="entry name" value="beta-trefoil_MIR_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12877">
        <property type="entry name" value="SPRY1_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12878">
        <property type="entry name" value="SPRY2_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBN-UNC-68 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000006">
        <property type="entry name" value="Protein CBR-LIPL-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000132">
        <property type="entry name" value="Ryanodine receptor 44F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ryanodine receptor isoform X2"/>
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        <property type="entry name" value="ryanodine receptor isoform X2"/>
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    </dbReference>
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        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ryanodine receptor, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="3"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035761">
        <property type="entry name" value="SPRY1_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035764">
        <property type="entry name" value="SPRY2_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035762">
        <property type="entry name" value="SPRY3_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4448"/>
            <end position="4471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4634"/>
            <end position="4651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4697"/>
            <end position="4719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4835"/>
            <end position="4857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4877"/>
            <end position="4902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4962"/>
            <end position="4981"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="19">
        <location>
            <begin position="102"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="580"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="1004"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="1475"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="4194"/>
            <end position="4229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1326"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3481"/>
            <end position="3501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="4538"/>
            <end position="4580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1343"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1362"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1393"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1428"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1457"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="3481"/>
            <end position="3492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="4544"/>
            <end position="4561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="SOF58811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="K11C4.5j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3I4"/>
        </source>
    </evidence>
    <sequence length="5083" mass="578050" checksum="B9B9D9EE8FA4AD6F" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3J1</accession>
    <name>A0A2C9C3J1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_F09G2.1</name>
        <name evidence="4 6" type="ORF">F09G2.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3J1"/>
    <dbReference type="SMR" id="A0A2C9C3J1"/>
    <dbReference type="AGR" id="WB:WBGene00017310"/>
    <dbReference type="WormBase" id="F09G2.1b">
        <property type="protein sequence ID" value="CE52192"/>
        <property type="gene ID" value="WBGene00017310"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017310">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3J1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000960">
        <property type="entry name" value="Protein CBG19102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000575">
        <property type="entry name" value="Protein KINase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF488">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="510"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SOF58836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F09G2.1b"/>
        </source>
    </evidence>
    <sequence length="952" mass="107831" checksum="B4BFF31C696CA37A" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3K0</accession>
    <name>A0A2C9C3K0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">jun-1</name>
        <name evidence="7" type="ORF">CELE_T24H10.7</name>
        <name evidence="9" type="ORF">T24H10.7</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Jun subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343785.1">
        <property type="nucleotide sequence ID" value="NM_001356878.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3K0"/>
    <dbReference type="SMR" id="A0A2C9C3K0"/>
    <dbReference type="GeneID" id="174452"/>
    <dbReference type="AGR" id="WB:WBGene00012005"/>
    <dbReference type="CTD" id="174452"/>
    <dbReference type="WormBase" id="T24H10.7f">
        <property type="protein sequence ID" value="CE52112"/>
        <property type="gene ID" value="WBGene00012005"/>
        <property type="gene designation" value="jun-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2187714at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012005">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3K0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14696">
        <property type="entry name" value="bZIP_Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="192"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SOF58777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="T24H10.7f"/>
        </source>
    </evidence>
    <sequence length="267" mass="28801" checksum="242EDB7F27769A4D" modified="2017-12-20" version="1">MIFSSSTLIDALRVMQTTNKYEFTGGAVSSPVLPVLQTAAFSPITPASASDMHTIVMSLLGNTPITSGPSIAPLSSPTLLPLVTSGDLDDLSMKILASSAIPGPPIISSSNSPDSSTTAVTTSQITAFQPLLNNFVSSTTASTSRPDKLNLTPPQQSAEIYAFNGVNSDDSDGGLDSRSASRCGMALDDQEKKKLERKRARNRQAATKCRQKKMDRIKELEEQVLHEKHRGQRLDAELLELNRALEHFRRTVEHHSGNGCPNNSIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3K3</accession>
    <name>A0A2C9C3K3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CELE_F36D4.4</name>
        <name evidence="13 15" type="ORF">F36D4.4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3K3"/>
    <dbReference type="SMR" id="A0A2C9C3K3"/>
    <dbReference type="AGR" id="WB:WBGene00018089"/>
    <dbReference type="WormBase" id="F36D4.4c">
        <property type="protein sequence ID" value="CE52327"/>
        <property type="gene ID" value="WBGene00018089"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839342at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018089">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3K3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000561">
        <property type="entry name" value="Protein CBG19271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="21"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SOF58846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F36D4.4c"/>
        </source>
    </evidence>
    <sequence length="456" mass="52070" checksum="EB9862D5FE72C535" modified="2017-12-20" version="1">MSMATTAVFLCGHLGALSVILNLFVIIALLRHRRRVLSNVFYVIVLHCAVLDVARGVCLILYGLPYFANSFYNINLDIHTRIHLFQLSRFALVILRVCNLLTIFNLLVFTTNEYIVIRYPLHYRRYFRRKFVLIILAICWTMSIMMALGILYSSSKSQTEWLPPEERGIDFATITMVLISSLCFVTLGTVVICYISILRTIRKFKDEGCLNNDESHRIHNRSLHRPINGQGSNCSNGSSLRGSKWRSVQAMSRHKYIYVIGSVLIVDLLFLCPYSGIQMVSFLHINNFLQITHGSTLIRWWLQVLIGVHSVCQPLCYFRMTEFRRLACCNPRRPWNRTKSFSQMNKSFANTRSNVREDENGNNTAEIEVTPNEPLLRNGENGGTPSRRSPTIAWTRGESVRFRTYGNEIGHHIPTKKNESKEPQCEIEMIPISTGSASPSDDSAVQIPIIDDSPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3L5</accession>
    <name>A0A2C9C3L5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome b-c1 complex subunit 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ucr-1</name>
        <name evidence="6" type="ORF">CELE_F56D2.1</name>
        <name evidence="8" type="ORF">F56D2.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SOF58789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343795.1">
        <property type="nucleotide sequence ID" value="NM_001356762.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3L5"/>
    <dbReference type="SMR" id="A0A2C9C3L5"/>
    <dbReference type="GeneID" id="175772"/>
    <dbReference type="AGR" id="WB:WBGene00018963"/>
    <dbReference type="CTD" id="175772"/>
    <dbReference type="WormBase" id="F56D2.1c">
        <property type="protein sequence ID" value="CE52122"/>
        <property type="gene ID" value="WBGene00018963"/>
        <property type="gene designation" value="ucr-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018963">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3L5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000008">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF143">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="4">
        <location>
            <begin position="48"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="5">
        <location>
            <begin position="200"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SOF58789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F56D2.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3L5"/>
        </source>
    </evidence>
    <sequence length="473" mass="51948" checksum="D260D2BBD6E85549" modified="2017-12-20" version="1">MALRLAVSSALRPALNSQVRNASSAVSVKDVLASAPQAEVTTLKNGFRVVTEDNGSATATVGVWIETGSRFENEKNNGVAHFLERLIHKGTGKRASAALESELNAIGAKLNSFTERDQTAVFVQAGAQDVEKVVDILADVLRNSKLEASTIDTERVNLLKELEASDDYHQLVLFDMLHAAGFQGTPLALSVLGTSESIPNISAQQLKEWQEDHYRPVRMVLSAVGGGVSNVSSLADKYFGDLSNEYPRKVPQVDGTRFTGSEYRYRNDNVPHMYAAFAVEGVGYAHKDALALQIANQFIVLGQWDVTHATSRTAASRLVQKIGHDHGVHNLQHFNINYKDTGLFGIYFVADAHDLNDTSGIMKSVAHEWKHLASAATEEEVAMAKNQFRTNLYQNLETNTQKAGFNAKELLYTGNLRQLSELEAQIQKVDAGAVREAISRHVYDRDLAAVGVGRTEAFPNYALTRAGMSWWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3L6</accession>
    <name>A0A2C9C3L6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TransThyretin-Related family domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_K02E11.4</name>
        <name evidence="2 4" type="ORF">K02E11.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3L6"/>
    <dbReference type="AGR" id="WB:WBGene00010513"/>
    <dbReference type="WormBase" id="K02E11.4b">
        <property type="protein sequence ID" value="CE11650"/>
        <property type="gene ID" value="WBGene00010513"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5781203at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010513">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3L6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35182">
        <property type="entry name" value="PROTEIN CBG13762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35182:SF4">
        <property type="entry name" value="SCP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012587137" evidence="1">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K02E11.4b"/>
        </source>
    </evidence>
    <sequence length="103" mass="11247" checksum="A706FC695E7C1EC2" modified="2017-12-20" version="1">MVRTCILAIFSLLVIGTNSQPGGGGMPGGGGMMYGKVNATVTISLPVSANYRRLVNKKKVPSGVTTYNKNKKALIIKKMRLEDFGDYMTGNKKTKLFVMNQTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3L8</accession>
    <name>A0A2C9C3L8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_K02E11.4</name>
        <name evidence="1 3" type="ORF">K02E11.4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3L8"/>
    <dbReference type="SMR" id="A0A2C9C3L8"/>
    <dbReference type="AGR" id="WB:WBGene00010513"/>
    <dbReference type="WormBase" id="K02E11.4d">
        <property type="protein sequence ID" value="CE52333"/>
        <property type="gene ID" value="WBGene00010513"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5781203at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010513">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3L8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35182">
        <property type="entry name" value="PROTEIN CBG13762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35182:SF4">
        <property type="entry name" value="SCP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SOF58858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="K02E11.4d"/>
        </source>
    </evidence>
    <sequence length="78" mass="8760" checksum="AFDED54B3C214CF6" modified="2017-12-20" version="1">MPGGGGMMYGKVNATVTISLPVSANYRRLVNKKKVPSGVTTYNKNKKALIIKKMRLEDFGDYMTGNKKTKLFVMNQTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3M8</accession>
    <name>A0A2C9C3M8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mics-1</name>
        <name evidence="6" type="ORF">CELE_T21C9.1</name>
        <name evidence="8" type="ORF">T21C9.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343863.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3M8"/>
    <dbReference type="SMR" id="A0A2C9C3M8"/>
    <dbReference type="GeneID" id="179475"/>
    <dbReference type="AGR" id="WB:WBGene00011890"/>
    <dbReference type="CTD" id="179475"/>
    <dbReference type="WormBase" id="T21C9.1b">
        <property type="protein sequence ID" value="CE06471"/>
        <property type="gene ID" value="WBGene00011890"/>
        <property type="gene designation" value="mics-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123971at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011890">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3M8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="73"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SOF58868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="T21C9.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C3M8"/>
        </source>
    </evidence>
    <sequence length="293" mass="32336" checksum="2D0011DAC33FE806" modified="2017-12-20" version="1">MMVSPPQEDTVFNTDSDPVYEHHAALVSSPFHADEDHTFDISFAAEATDDMTFNDTTTDGNGQESVPLEALTVVEIEKTSKGFGFNIVGGTDNPHFVGDIGIYVSSVNSESKSYGVVRTGDKILSFDGIDMTYKTHDEAVEVFRSVKIGHVAKMLIDREYLHLQEDRTQTPTASVSITPQVTPQTRSTQNNTDTPKSMSHSESKSRLTSHGLSAVIERIRGKVYEEEDAQSVTSYAPSTHSIIDDVPRTPRKPLSLLDPRNNSWLTEALYVSIGLGALTISGYLAYRFIRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3N2</accession>
    <name>A0A2C9C3N2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ceh-22</name>
        <name evidence="11" type="ORF">CELE_F29F11.5</name>
        <name evidence="13" type="ORF">F29F11.5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343841.1">
        <property type="nucleotide sequence ID" value="NM_001356738.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3N2"/>
    <dbReference type="SMR" id="A0A2C9C3N2"/>
    <dbReference type="GeneID" id="179485"/>
    <dbReference type="AGR" id="WB:WBGene00000445"/>
    <dbReference type="CTD" id="179485"/>
    <dbReference type="WormBase" id="F29F11.5d">
        <property type="protein sequence ID" value="CE52111"/>
        <property type="gene ID" value="WBGene00000445"/>
        <property type="gene designation" value="ceh-22"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3137333at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000445">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3N2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000101">
        <property type="entry name" value="NK2 homeobox 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF82">
        <property type="entry name" value="HOMEOBOX PROTEIN VND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="222"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SOF58841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F29F11.5d"/>
        </source>
    </evidence>
    <sequence length="379" mass="41390" checksum="66A262188B7A35F5" modified="2017-12-20" version="1">MFNVSALAAATPSIASVSSVASPSEQHGLSTSVGVGVNDTTSRTGDGGAASSASSASAAPQQQSQSALHNKTFHFYIHNFSIRVIHFYSIISKKFFGENSKSLEAKWDTLLPTDTNLQCSTWPDSIPLLAVSGYSATPTFSFDPCTYGSYDPSAYFASNGIAGSMYTLPDQFPRSENDMLDNSNTSNGNKSDKDGIKLEDEDEILEDEENDEEDDGTGKRKKRKRRVLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTDKPINAALLTTMPNAFSSQSTAASFPTRAMPIPMLVRDSSARSSDISSTSPYTVAFGSANSGYLPTPSAYLPATSGYFSNGPSAASSYMTNTQWWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P6P940</accession>
    <name>A0A3P6P940_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">tag-296</name>
        <name evidence="2" type="ORF">CELE_F49D11.9</name>
        <name evidence="4" type="ORF">F49D11.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="VDJ62021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001355496.1">
        <property type="nucleotide sequence ID" value="NM_001368568.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P6P940"/>
    <dbReference type="SMR" id="A0A3P6P940"/>
    <dbReference type="GeneID" id="172997"/>
    <dbReference type="KEGG" id="cel:CELE_F49D11.9"/>
    <dbReference type="AGR" id="WB:WBGene00018632"/>
    <dbReference type="CTD" id="172997"/>
    <dbReference type="WormBase" id="F49D11.9a">
        <property type="protein sequence ID" value="CE52927"/>
        <property type="gene ID" value="WBGene00018632"/>
        <property type="gene designation" value="tag-296"/>
    </dbReference>
    <dbReference type="OrthoDB" id="116883at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3P6P940">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120013">
        <property type="term" value="F:lipid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF43">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="1">
        <location>
            <begin position="44"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDJ62021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F49D11.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A3P6P940"/>
        </source>
    </evidence>
    <sequence length="225" mass="25373" checksum="5E495E593752E4E2" modified="2019-02-13" version="1">MTEDTASPFCIKLVATQMKKLSTDVIIVEKSDVENCPEVTPDDVELLTFVEVYEELCKFIGMLGKIFEFVEKDVREKIDLLKELHTANPEGYKTVVALVHSEKPMEKNGKESGAVAILHLNRALEFIVEFMYAAVAATNDDSIPKICKECYDGTLAKHHPWIIRTAVKVAVYTLPTREKMLDYLKGSVTDESLIRVLIDDVVSHGKIVHSRINTIYTVHELHKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7R9XNC6</accession>
    <name>A0A7R9XNC6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FIP (Fungus-Induced Protein) Related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y48G8AL.16</name>
        <name evidence="2 4" type="ORF">Y48G8AL.16</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAD8108835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7R9XNC6"/>
    <dbReference type="AGR" id="WB:WBGene00195068"/>
    <dbReference type="WormBase" id="Y48G8AL.16b">
        <property type="protein sequence ID" value="CE54288"/>
        <property type="gene ID" value="WBGene00195068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031538178" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD8108835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y48G8AL.16b"/>
        </source>
    </evidence>
    <sequence length="35" mass="3574" checksum="C9A10D4A81A47398" modified="2021-06-02" version="1">MRFFILFTSMIAASSAFLFPSAGGGGGGCGCRISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7R9XND1</accession>
    <name>A0A7R9XND1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cyh-1</name>
        <name evidence="8" type="ORF">CELE_Y49F6B.1</name>
        <name evidence="10" type="ORF">Y49F6B.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAD8118635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379356.1">
        <property type="nucleotide sequence ID" value="NM_001393043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7R9XND1"/>
    <dbReference type="SMR" id="A0A7R9XND1"/>
    <dbReference type="GeneID" id="190078"/>
    <dbReference type="AGR" id="WB:WBGene00021714"/>
    <dbReference type="CTD" id="190078"/>
    <dbReference type="WormBase" id="Y49F6B.1f">
        <property type="protein sequence ID" value="CE54266"/>
        <property type="gene ID" value="WBGene00021714"/>
        <property type="gene designation" value="cyh-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000029">
        <property type="entry name" value="Cyclin h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000393">
        <property type="entry name" value="CYclin H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="161"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD8118635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y49F6B.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A7R9XND1"/>
        </source>
    </evidence>
    <sequence length="334" mass="39287" checksum="3CF210E6BE50E5D9" modified="2021-06-02" version="1">MYATSTQKREWTYTPEKLAAMRLEINIKFRQKYESVMQPDELELFVTPEEELRMQRSIEDAALKFADKFRPHIWPSVKWTALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEFYITIEDFVKNMNYSVGEPRQNAERILKLEPELMKILDYNLTVHCPYRPYEGHLMDMKTRMLLLNFDLESIRRDSMRFFQNALQTDVLLLYPPSQIALAAINFGLHAQGKSDEILREFLRKLIGIEEDSWAHRDARPEDLEKLEKTVTRVNQIMREVDRNFVAVTEQERENHKSQLARIQALIPALDERRKEQWLAGGGVGLMPGELAEQPVDSDDEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7R9XND6</accession>
    <name>A0A7R9XND6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hpc2-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">pqn-80</name>
        <name evidence="3" type="ORF">CELE_Y111B2A.14</name>
        <name evidence="5" type="ORF">Y111B2A.14</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAD8126150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001382699.1">
        <property type="nucleotide sequence ID" value="NM_001395775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7R9XND6"/>
    <dbReference type="SMR" id="A0A7R9XND6"/>
    <dbReference type="GeneID" id="176683"/>
    <dbReference type="AGR" id="WB:WBGene00004161"/>
    <dbReference type="CTD" id="176683"/>
    <dbReference type="WormBase" id="Y111B2A.14t">
        <property type="protein sequence ID" value="CE54314"/>
        <property type="gene ID" value="WBGene00004161"/>
        <property type="gene designation" value="pqn-80"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68076at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
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        <location>
            <begin position="232"/>
            <end position="248"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
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    </feature>
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        <location>
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            <end position="300"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="743"/>
            <end position="783"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        <source>
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            <dbReference type="PeptideAtlas" id="A0A7R9XND6"/>
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    </evidence>
    <sequence length="815" mass="90598" checksum="A2E2D4668DF2E59F" modified="2021-06-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>C1P634</accession>
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        <submittedName>
            <fullName evidence="5">Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2</fullName>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
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    <dbReference type="EMBL" id="BX284604">
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        <property type="nucleotide sequence ID" value="NM_001268650.4"/>
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    <dbReference type="AlphaFoldDB" id="C1P634"/>
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        <property type="protein sequence ID" value="CE43603"/>
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        <property type="gene designation" value="magi-1"/>
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        <property type="component" value="Chromosome IV"/>
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    <dbReference type="Bgee" id="WBGene00010444">
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    </dbReference>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="603"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="178"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAX65064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="K01A6.2b"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="C1P634"/>
        </source>
    </evidence>
    <sequence length="855" mass="93352" checksum="0430786F8CCF5B80" modified="2009-05-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-26" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>C1P635</accession>
    <name>C1P635_CAEEL</name>
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        <recommendedName>
            <fullName evidence="6">Guanylate kinase</fullName>
            <ecNumber evidence="5">2.7.4.8</ecNumber>
        </recommendedName>
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            <fullName evidence="14">GMP kinase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="20 22" type="primary">magi-1</name>
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        <name evidence="22" type="ORF">K01A6.2</name>
    </gene>
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        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GMP + ATP = GDP + ADP</text>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="interaction">
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            <id>C1P635</id>
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        <interactant intactId="EBI-314262">
            <id>Q9TZ84</id>
            <label>CELE_F54D10.7</label>
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        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-2917046">
            <id>C1P635</id>
        </interactant>
        <interactant intactId="EBI-328477">
            <id>O45952</id>
            <label>csc-1</label>
        </interactant>
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        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-2917046">
            <id>C1P635</id>
        </interactant>
        <interactant intactId="EBI-316187">
            <id>Q18426</id>
            <label>prx-5</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the guanylate kinase family.</text>
    </comment>
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        <property type="gene ID" value="WBGene00010444"/>
        <property type="gene designation" value="magi-1"/>
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    <dbReference type="Bgee" id="WBGene00010444">
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
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        <property type="evidence" value="ECO:0000314"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:glutamate receptor binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:long-term memory"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd06731">
        <property type="entry name" value="PDZ1_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06732">
        <property type="entry name" value="PDZ2_MAGI-1_3-like"/>
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    </dbReference>
    <dbReference type="CDD" id="cd06733">
        <property type="entry name" value="PDZ3_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ4_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000005">
        <property type="entry name" value="Guanylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000252">
        <property type="entry name" value="MAGI (Membrane Associated Guanylate kinase Inverted) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000005">
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        <property type="entry name" value="Membrane associated guanylate kinase, WW and PDZ domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000001">
        <property type="entry name" value="Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000034">
        <property type="entry name" value="syntaxin-binding protein 4 isoform X1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
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        <property type="entry name" value="Guanylate_kin-like_dom"/>
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    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_sf"/>
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    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
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        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316:SF40">
        <property type="entry name" value="LD27118P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316">
        <property type="entry name" value="MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="18">
        <location>
            <begin position="152"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="17">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="17">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="424"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="537"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="719"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="823"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="337"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="613"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAX65065.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="K01A6.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="C1P635"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110025" checksum="471DC8425F735C62" modified="2012-01-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-26" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>C1P636</accession>
    <name>C1P636_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">E1 ubiquitin-activating enzyme</fullName>
            <ecNumber evidence="5">6.2.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-activating enzyme E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">uba-1</name>
        <name evidence="17" type="ORF">C47E12.5</name>
        <name evidence="15" type="ORF">CELE_C47E12.5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="5"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAX65051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367213.1">
        <property type="nucleotide sequence ID" value="NM_001380424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C1P636"/>
    <dbReference type="SMR" id="C1P636"/>
    <dbReference type="PeptideAtlas" id="C1P636"/>
    <dbReference type="GeneID" id="177855"/>
    <dbReference type="AGR" id="WB:WBGene00006699"/>
    <dbReference type="CTD" id="177855"/>
    <dbReference type="WormBase" id="C47E12.5c">
        <property type="protein sequence ID" value="CE43638"/>
        <property type="gene ID" value="WBGene00006699"/>
        <property type="gene designation" value="uba-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006699">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C1P636">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045138">
        <property type="term" value="P:nematode male tail tip morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050905">
        <property type="term" value="P:neuromuscular process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010623">
        <property type="term" value="P:programmed cell death involved in cell development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative ubiquitin-activating enzyme e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="14">
        <location>
            <begin position="982"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAX65051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C47E12.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="C1P636"/>
        </source>
    </evidence>
    <sequence length="1112" mass="123956" checksum="D50B058D5BA2BB57" modified="2009-05-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-26" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>C1P639</accession>
    <name>C1P639_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Globin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">glb-19</name>
        <name evidence="6" type="ORF">CELE_F56C4.3</name>
        <name evidence="8" type="ORF">F56C4.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAX65060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255497.1">
        <property type="nucleotide sequence ID" value="NM_001268568.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C1P639"/>
    <dbReference type="SMR" id="C1P639"/>
    <dbReference type="GeneID" id="3565034"/>
    <dbReference type="AGR" id="WB:WBGene00010146"/>
    <dbReference type="CTD" id="3565034"/>
    <dbReference type="WormBase" id="F56C4.3b">
        <property type="protein sequence ID" value="CE43654"/>
        <property type="gene ID" value="WBGene00010146"/>
        <property type="gene designation" value="glb-19"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070675_0_0_1"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010146">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C1P639">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF22">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="10"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAX65060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F56C4.3b"/>
        </source>
    </evidence>
    <sequence length="206" mass="24045" checksum="6D1DA26B8017895D" modified="2009-05-26" version="1">MAPAAISWYSFTQEEKNDLEHSWNLVEGKKNHIACDIYEMIFNQCPEARRLFPKLKFVGSKPDRKNNEFAFQAMRFMQVIEGAVKALDHLTSLDVILDNLGRRHGKLEVNGKFRSYYWSVFLECSIYCLRHAFSKRMNDKEVDHVIILWRYLLRDVMKKIKAGTTADIAHRLHQMSLDDSRKYSLPAIQHKESNASSANTDFDDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>C1P640</accession>
    <name>C1P640_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Laminin-like protein epi-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">epi-1</name>
        <name evidence="19" type="ORF">CELE_K08C7.3</name>
        <name evidence="21" type="ORF">K08C7.3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAX65067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255500.1">
        <property type="nucleotide sequence ID" value="NM_001268571.3"/>
    </dbReference>
    <dbReference type="SMR" id="C1P640"/>
    <dbReference type="PeptideAtlas" id="C1P640"/>
    <dbReference type="GeneID" id="177956"/>
    <dbReference type="AGR" id="WB:WBGene00001328"/>
    <dbReference type="CTD" id="177956"/>
    <dbReference type="WormBase" id="K08C7.3c">
        <property type="protein sequence ID" value="CE43544"/>
        <property type="gene ID" value="WBGene00001328"/>
        <property type="gene designation" value="epi-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011303at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001328">
        <property type="expression patterns" value="Expressed in embryo and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C1P640">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007414">
        <property type="term" value="P:axonal defasciculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071711">
        <property type="term" value="P:basement membrane organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051788">
        <property type="term" value="P:response to misfolded protein"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000083">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000388">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000082">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000189">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000017">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000034">
        <property type="entry name" value="Laminin subunit alpha 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000407">
        <property type="entry name" value="Laminin subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000160">
        <property type="entry name" value="Laminin subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000711">
        <property type="entry name" value="Laminin-like protein epi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000726">
        <property type="entry name" value="Laminin-like protein epi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000222">
        <property type="entry name" value="Laminin-like protein epi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000264">
        <property type="entry name" value="Laminin-like protein epi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000272">
        <property type="entry name" value="Laminin-like protein epi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000306">
        <property type="entry name" value="Laminin-like protein epi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010307">
        <property type="entry name" value="Laminin_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06009">
        <property type="entry name" value="Laminin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002912422" evidence="14">
        <location>
            <begin position="28"/>
            <end position="3683"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="18">
        <location>
            <begin position="26"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="427"/>
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        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="472"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="519"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="564"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="610"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="656"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="701"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="756"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1426"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1472"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1517"/>
            <end position="1564"/>
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    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1565"/>
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        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="17">
        <location>
            <begin position="1627"/>
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    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1841"/>
            <end position="1890"/>
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    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1891"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1948"/>
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        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="2001"/>
            <end position="2044"/>
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    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="2048"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="2095"/>
            <end position="2142"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2704"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2907"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="3083"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="3321"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="3499"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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        <location>
            <begin position="2318"/>
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    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="2489"/>
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    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="2547"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="3282"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="447"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="472"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="474"/>
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    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="493"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="519"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="521"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="540"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="564"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="566"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="585"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="612"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="631"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="676"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="726"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="779"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1426"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1428"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1447"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1489"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1540"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1565"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1567"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1586"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1860"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1918"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1984"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2020"/>
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    <feature type="disulfide bond" evidence="11">
        <location>
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    <feature type="disulfide bond" evidence="11">
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    <feature type="disulfide bond" evidence="11">
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    <feature type="disulfide bond" evidence="11">
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            <begin position="2116"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004302"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
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    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
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    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAX65067.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WormBase" id="K08C7.3c"/>
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    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PeptideAtlas" id="C1P640"/>
        </source>
    </evidence>
    <sequence length="3683" mass="405634" checksum="47FEF937235C14D5" modified="2009-05-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>C1P641</accession>
    <name>C1P641_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Laminin-like protein epi-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">epi-1</name>
        <name evidence="19" type="ORF">CELE_K08C7.3</name>
        <name evidence="21" type="ORF">K08C7.3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAX65068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255501.1">
        <property type="nucleotide sequence ID" value="NM_001268572.3"/>
    </dbReference>
    <dbReference type="SMR" id="C1P641"/>
    <dbReference type="GeneID" id="177956"/>
    <dbReference type="AGR" id="WB:WBGene00001328"/>
    <dbReference type="CTD" id="177956"/>
    <dbReference type="WormBase" id="K08C7.3d">
        <property type="protein sequence ID" value="CE43590"/>
        <property type="gene ID" value="WBGene00001328"/>
        <property type="gene designation" value="epi-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000301_1_0_1"/>
    <dbReference type="OrthoDB" id="10011303at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001328">
        <property type="expression patterns" value="Expressed in embryo and 12 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C1P641">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007414">
        <property type="term" value="P:axonal defasciculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071711">
        <property type="term" value="P:basement membrane organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051788">
        <property type="term" value="P:response to misfolded protein"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000083">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000388">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000082">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000189">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000017">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000034">
        <property type="entry name" value="Laminin subunit alpha 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000407">
        <property type="entry name" value="Laminin subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000160">
        <property type="entry name" value="Laminin subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000711">
        <property type="entry name" value="Laminin-like protein epi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000726">
        <property type="entry name" value="Laminin-like protein epi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000222">
        <property type="entry name" value="Laminin-like protein epi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000264">
        <property type="entry name" value="Laminin-like protein epi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000272">
        <property type="entry name" value="Laminin-like protein epi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000306">
        <property type="entry name" value="Laminin-like protein epi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010307">
        <property type="entry name" value="Laminin_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06009">
        <property type="entry name" value="Laminin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002912406" evidence="14">
        <location>
            <begin position="28"/>
            <end position="3663"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="18">
        <location>
            <begin position="26"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="427"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="472"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="519"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="564"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="610"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="656"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="701"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="756"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1406"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1452"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1497"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1545"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="17">
        <location>
            <begin position="1607"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1821"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1871"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1928"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1981"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="2028"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="2075"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2684"/>
            <end position="2875"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2887"/>
            <end position="3057"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="3063"/>
            <end position="3226"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="3301"/>
            <end position="3473"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="3479"/>
            <end position="3660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="3227"/>
            <end position="3285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="2298"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="2469"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="2527"/>
            <end position="2614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="3262"/>
            <end position="3271"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="564"/>
            <end position="576"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAX65058.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="C1P648"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-05-26" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>C1P655</accession>
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        <recommendedName>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.2" evidence="3"/>
    <dbReference type="EMBL" id="BX284604">
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    </dbReference>
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    </dbReference>
    <dbReference type="SMR" id="C1P655"/>
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    <dbReference type="GeneID" id="178510"/>
    <dbReference type="AGR" id="WB:WBGene00012131"/>
    <dbReference type="CTD" id="178510"/>
    <dbReference type="WormBase" id="T28F3.5b">
        <property type="protein sequence ID" value="CE43661"/>
        <property type="gene ID" value="WBGene00012131"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
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            <end position="515"/>
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        <location>
            <begin position="169"/>
            <end position="375"/>
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        <location>
            <begin position="641"/>
            <end position="719"/>
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        <location>
            <begin position="1020"/>
            <end position="1349"/>
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        <location>
            <begin position="1351"/>
            <end position="1522"/>
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        <location>
            <begin position="1563"/>
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            <begin position="1582"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023267"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50968"/>
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    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50980"/>
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    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
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    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAX65073.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="T28F3.5b"/>
        </source>
    </evidence>
    <sequence length="1593" mass="178665" checksum="00404B232F399867" modified="2009-05-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-05-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>C1P658</accession>
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        <submittedName>
            <fullName evidence="9">Papilin</fullName>
        </submittedName>
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        <name evidence="9 11" type="primary">mlt-11</name>
        <name evidence="9" type="ORF">CELE_W01F3.3</name>
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    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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</entry>
<entry dataset="TrEMBL" created="2009-05-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>C1P659</accession>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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</entry>
<entry dataset="TrEMBL" created="2009-05-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1474"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1484"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1955"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1987"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAX65076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="W01F3.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="C1P660"/>
        </source>
    </evidence>
    <sequence length="2603" mass="282810" checksum="8FEC83E0F1F9AEBC" modified="2009-05-26" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>D0Z5N4-2</accession>
    <name>E2AKB_CAEEL</name>
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        <recommendedName>
            <fullName evidence="3">Isoform a of Eukaryotic translation initiation factor 2-alpha kinase gcn-2</fullName>
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        <alternativeName>
            <fullName evidence="6">General control nonderepressible kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gcn-2</name>
        <name evidence="6" type="ORF">Y81G3A.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="Mol. Cell. Biol." volume="30" first="5033" last="5042">
            <title>Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery.</title>
            <authorList>
                <person name="Mao X.R."/>
                <person name="Crowder C.M."/>
            </authorList>
            <dbReference type="PubMed" id="20733002"/>
            <dbReference type="DOI" id="10.1128/MCB.00922-10"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
            <authorList>
                <person name="Lee E.C."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1002760" last="E1002760">
            <title>Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2.</title>
            <authorList>
                <person name="Baker B.M."/>
                <person name="Nargund A.M."/>
                <person name="Sun T."/>
                <person name="Haynes C.M."/>
            </authorList>
            <dbReference type="PubMed" id="22719267"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002760"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2013" name="Aging Cell" volume="12" first="742" last="751">
            <title>The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Rousakis A."/>
                <person name="Vlassis A."/>
                <person name="Vlanti A."/>
                <person name="Patera S."/>
                <person name="Thireos G."/>
                <person name="Syntichaki P."/>
            </authorList>
            <dbReference type="PubMed" id="23692540"/>
            <dbReference type="DOI" id="10.1111/acel.12101"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>D0Z5N4-1</id>
            <name evidence="6">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>D0Z5N4-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_057682"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001366669.1">
        <property type="nucleotide sequence ID" value="NM_001381637.2"/>
    </dbReference>
    <dbReference type="WormBase" id="Y81G3A.3a">
        <property type="protein sequence ID" value="CE47938"/>
        <property type="gene ID" value="WBGene00013591"/>
        <property type="gene designation" value="gcn-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q19192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="22719267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y81G3A.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y81G3A.3b"/>
        </source>
    </evidence>
    <sequence length="1696" mass="190854" checksum="C3DC9E3C6E6DE9A4" modified="2013-02-06" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFN0</accession>
    <name>D7SFN0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">vps-54</name>
        <name evidence="10" type="ORF">CELE_T21C9.2</name>
        <name evidence="12" type="ORF">T21C9.2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBM41226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256227.1">
        <property type="nucleotide sequence ID" value="NM_001269298.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFN0"/>
    <dbReference type="SMR" id="D7SFN0"/>
    <dbReference type="PeptideAtlas" id="D7SFN0"/>
    <dbReference type="GeneID" id="179473"/>
    <dbReference type="AGR" id="WB:WBGene00006934"/>
    <dbReference type="CTD" id="179473"/>
    <dbReference type="WormBase" id="T21C9.2b">
        <property type="protein sequence ID" value="CE45051"/>
        <property type="gene ID" value="WBGene00006934"/>
        <property type="gene designation" value="vps-54"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005185_1_0_1"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006934">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFN0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="509"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBM41226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="T21C9.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="D7SFN0"/>
        </source>
    </evidence>
    <sequence length="749" mass="84773" checksum="02061386214550CB" modified="2010-08-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFN1</accession>
    <name>D7SFN1_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C12D8.21</name>
        <name evidence="2" type="ORF">CELE_C12D8.21</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBM41190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256200.1">
        <property type="nucleotide sequence ID" value="NM_001269271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFN1"/>
    <dbReference type="GeneID" id="13214696"/>
    <dbReference type="AGR" id="WB:WBGene00195157"/>
    <dbReference type="CTD" id="13214696"/>
    <dbReference type="WormBase" id="C12D8.21b">
        <property type="protein sequence ID" value="CE45049"/>
        <property type="gene ID" value="WBGene00195157"/>
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    <dbReference type="HOGENOM" id="CLU_2560378_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00195157">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFN1">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBM41190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C12D8.21b"/>
        </source>
    </evidence>
    <sequence length="25" mass="2835" checksum="EA4D53D3812E590B" modified="2010-08-10" version="1">MGMNLEPKQQRIPKKDAPTVQPKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFN2</accession>
    <name>D7SFN2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3501 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C12D8.9</name>
        <name evidence="1" type="ORF">CELE_C12D8.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBM41188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256202.1">
        <property type="nucleotide sequence ID" value="NM_001269273.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFN2"/>
    <dbReference type="GeneID" id="182543"/>
    <dbReference type="AGR" id="WB:WBGene00007538"/>
    <dbReference type="CTD" id="182543"/>
    <dbReference type="WormBase" id="C12D8.9b">
        <property type="protein sequence ID" value="CE45079"/>
        <property type="gene ID" value="WBGene00007538"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157471_0_0_1"/>
    <dbReference type="OrthoDB" id="5777742at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007538">
        <property type="expression patterns" value="Expressed in material anatomical entity and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFN2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBM41188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C12D8.9b"/>
        </source>
    </evidence>
    <sequence length="65" mass="7599" checksum="078F5295F5EE250F" modified="2010-08-10" version="1">MHRASQIRIKQRYNCAEQEVTQMRAPFLGFSVFVRFQSRARAHTIKIINEDEVEQMLASSPVPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFN6</accession>
    <name>D7SFN6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">micu-3</name>
        <name evidence="12" type="ORF">C56A3.6</name>
        <name evidence="10" type="ORF">CELE_C56A3.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBM41197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256519.1">
        <property type="nucleotide sequence ID" value="NM_001269590.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFN6"/>
    <dbReference type="SMR" id="D7SFN6"/>
    <dbReference type="PeptideAtlas" id="D7SFN6"/>
    <dbReference type="GeneID" id="179837"/>
    <dbReference type="KEGG" id="cel:CELE_C56A3.6"/>
    <dbReference type="AGR" id="WB:WBGene00008345"/>
    <dbReference type="CTD" id="179837"/>
    <dbReference type="WormBase" id="C56A3.6b">
        <property type="protein sequence ID" value="CE45077"/>
        <property type="gene ID" value="WBGene00008345"/>
        <property type="gene designation" value="micu-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027103_0_1_1"/>
    <dbReference type="OrthoDB" id="5859791at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFN6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15900">
        <property type="entry name" value="EFh_MICU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF13">
        <property type="entry name" value="MITOCHONDRIAL CALCIUM UPTAKE 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBM41197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C56A3.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="D7SFN6"/>
        </source>
    </evidence>
    <sequence length="398" mass="46123" checksum="7674B36F4117161B" modified="2010-08-10" version="1">MKRVLSRFWGFSTKHRQHILNQRIVERTSARNVAVLTAAGIGTSIGAYQLIDTARAGILDGSDDASRHNVTTDHKLTKRELRFLQFASVEYDDVIYMSPMDFIDSLTLDAPRERVYRRVLKEKDIQRILKKTPPFRSGGKHFFRTMDQSGIISYSEYIFLLTLLTKSKAAFRIAFLMFDEDDNGNIDRDEFMLKSEEEVRKQDTTLLLHLFGLRGNATLSFDEFQQFYENLQEELMEIEFYEFARGKTAISPVDFARLILRYSIVNFDDYHKYLQRVQEKSDDDEPGISLSQWATFSRFLNNLAEFQSAVRLYVNSNVPVSEPEFARAVGCTIGKELDPVVVSMIFRIFDENNDGTLSYPEFLAVMSDRLHRGLRGRLEKPWGWKPFKNCVISEVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFP1</accession>
    <name>D7SFP1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F28F8.9</name>
        <name evidence="1 3" type="ORF">F28F8.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBM41202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256677.1">
        <property type="nucleotide sequence ID" value="NM_001269748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFP1"/>
    <dbReference type="SMR" id="D7SFP1"/>
    <dbReference type="GeneID" id="3896822"/>
    <dbReference type="AGR" id="WB:WBGene00044188"/>
    <dbReference type="CTD" id="3896822"/>
    <dbReference type="WormBase" id="F28F8.9c">
        <property type="protein sequence ID" value="CE45039"/>
        <property type="gene ID" value="WBGene00044188"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2401638_0_0_1"/>
    <dbReference type="OrthoDB" id="5866729at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044188">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFP1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBM41202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F28F8.9c"/>
        </source>
    </evidence>
    <sequence length="93" mass="11134" checksum="B8E15A028AA1782B" modified="2010-08-10" version="1">MEIDEFSCQLLKKMARYLLGATMYVEDVLRRDDWSLEETENVKKYFKNVKSFKIPKIEKRKAEEFDEPCRKRSICSAESRRRSSKMICRLASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFP2</accession>
    <name>D7SFP2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">avr-15</name>
        <name evidence="3" type="ORF">CELE_R11G10.1</name>
        <name evidence="5" type="ORF">R11G10.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBM41221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256513.1">
        <property type="nucleotide sequence ID" value="NM_001269584.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFP2"/>
    <dbReference type="SMR" id="D7SFP2"/>
    <dbReference type="GeneID" id="179834"/>
    <dbReference type="AGR" id="WB:WBGene00000233"/>
    <dbReference type="CTD" id="179834"/>
    <dbReference type="WormBase" id="R11G10.1c">
        <property type="protein sequence ID" value="CE45109"/>
        <property type="gene ID" value="WBGene00000233"/>
        <property type="gene designation" value="avr-15"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010920_1_4_1"/>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000233">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFP2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031987">
        <property type="term" value="P:locomotion involved in locomotory behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043051">
        <property type="term" value="P:regulation of nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd19062">
        <property type="entry name" value="LGIC_TM_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044721">
        <property type="entry name" value="GluCl_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBM41221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="R11G10.1c"/>
        </source>
    </evidence>
    <sequence length="179" mass="20783" checksum="CE144D31DEBDBE1E" modified="2010-08-10" version="1">MLVIVSWVSFWIDRTAVPARVTLGVTTLLTMTTQSSGINAKLPPVAYIKAIDVWIGACMTFIFCALLEFAWVTYIANKQDANKRARTEREKAELPFLQNSHNDVWVPREVAEQEREVMTVRMNRRQTNSVWKWIKTKTEWNDKSKRADLISRVMFPVLFLTFNISYWTHYGQYGVAIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFP4</accession>
    <name>D7SFP4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">pri-2</name>
        <name evidence="12" type="ORF">CELE_W02D9.1</name>
        <name evidence="14" type="ORF">W02D9.1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CBM41229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001251923.1">
        <property type="nucleotide sequence ID" value="NM_001264994.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFP4"/>
    <dbReference type="SMR" id="D7SFP4"/>
    <dbReference type="PeptideAtlas" id="D7SFP4"/>
    <dbReference type="GeneID" id="173122"/>
    <dbReference type="AGR" id="WB:WBGene00004181"/>
    <dbReference type="CTD" id="173122"/>
    <dbReference type="WormBase" id="W02D9.1b">
        <property type="protein sequence ID" value="CE45071"/>
        <property type="gene ID" value="WBGene00004181"/>
        <property type="gene designation" value="pri-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026253_2_0_1"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004181">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFP4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110039">
        <property type="term" value="P:positive regulation of nematode male tail tip morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="118"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBM41229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="W02D9.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="D7SFP4"/>
        </source>
    </evidence>
    <sequence length="322" mass="37044" checksum="C6270151669AC7AD" modified="2010-08-10" version="1">MIEDLEAACQFNLFEAPNKTFYKVDFIDAIELIRRGSVHLKKGFAYFPFDDLVTILVTKMKNNMMAAMARSFKHLAILEEEGRLLPRLSLLSNNAYSGKDYNGEQPDGSIIVTRHMIDKLSRRSFAPCMKQMHNHLRVNHHLKYGARRQYGLFLKGIGLSLDEAIAMMRDEFTKKITSDKFDKEYGYNIRYMYGKEGRRVAQTAMSCATIILRNPPSAVDCHGCPFRHSEKQVLKQKLGSDAILKKEQIERIAELAELNQYDKACTRYFEFMHNLEEGGLGQLITHPNQFYEESQKIVAERIAAKQESQEAPAPKIEKMDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFP5</accession>
    <name>D7SFP5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CELE_W02D9.2</name>
        <name evidence="9 11" type="ORF">W02D9.2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CBM41230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001251926.1">
        <property type="nucleotide sequence ID" value="NM_001264997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFP5"/>
    <dbReference type="GeneID" id="173123"/>
    <dbReference type="AGR" id="WB:WBGene00012208"/>
    <dbReference type="CTD" id="173123"/>
    <dbReference type="WormBase" id="W02D9.2c">
        <property type="protein sequence ID" value="CE45108"/>
        <property type="gene ID" value="WBGene00012208"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059592_3_0_1"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012208">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFP5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="72"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBM41230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="W02D9.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="D7SFP5"/>
        </source>
    </evidence>
    <sequence length="215" mass="23678" checksum="7417EBC1C7BD453A" modified="2010-08-10" version="1">MAAEQTANLSGNIAGMSAPKSSSNRRGPMQEVDLDAEFDTLEEPVWDTVKRDVLTVGAKFTHVVLPHGDKQQLLRDWDLWGPLFICVGLALLLQHNGGTESAPQFTQVFTITFFGSVIVTANIKLLGGNISFFQSLCVIGYCLLPPFVAAVLCSLFLHGIAFPLRLLITSIGFVWSTYASMGFLAGCQPDKKRLLVIYPVFLFYFVVSWMIISHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFP9</accession>
    <name>D7SFP9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C40H5.2</name>
        <name evidence="2" type="ORF">CELE_C40H5.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CBM41193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257167.1">
        <property type="nucleotide sequence ID" value="NM_001270238.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFP9"/>
    <dbReference type="SMR" id="D7SFP9"/>
    <dbReference type="GeneID" id="183369"/>
    <dbReference type="AGR" id="WB:WBGene00008045"/>
    <dbReference type="CTD" id="183369"/>
    <dbReference type="WormBase" id="C40H5.2b">
        <property type="protein sequence ID" value="CE45112"/>
        <property type="gene ID" value="WBGene00008045"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118746_0_0_1"/>
    <dbReference type="OrthoDB" id="5772665at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008045">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFP9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBM41193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C40H5.2b"/>
        </source>
    </evidence>
    <sequence length="115" mass="13086" checksum="24CC13296B8F8AE4" modified="2010-08-10" version="1">MCPPTFHGPFCQFDVNATNYSWSALEIALLFFVVFMIAFAIFIVCCASSNKMGFYISVPNKHYNRWAEEDDMFDDLPTENGEQLMAMADIRKGIVVSKTRETVLEDLEDSAILQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFR0</accession>
    <name>D7SFR0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srh-167</name>
        <name evidence="2" type="ORF">CELE_F57G8.3</name>
        <name evidence="4" type="ORF">F57G8.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBM41210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256704.1">
        <property type="nucleotide sequence ID" value="NM_001269775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFR0"/>
    <dbReference type="GeneID" id="186466"/>
    <dbReference type="AGR" id="WB:WBGene00005383"/>
    <dbReference type="CTD" id="186466"/>
    <dbReference type="WormBase" id="F57G8.3b">
        <property type="protein sequence ID" value="CE45053"/>
        <property type="gene ID" value="WBGene00005383"/>
        <property type="gene designation" value="srh-167"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042960_1_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005383">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFR0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019422">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10318">
        <property type="entry name" value="7TM_GPCR_Srh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003105904" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBM41210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F57G8.3b"/>
        </source>
    </evidence>
    <sequence length="53" mass="5976" checksum="B843271BDEECD39E" modified="2010-08-10" version="1">MSSIAVHGILLTITMLIVHAPYRQAVLEIICNRSKMATINNPQIWKTVNETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFR1</accession>
    <name>D7SFR1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">unc-101</name>
        <name evidence="6" type="ORF">CELE_K11D2.3</name>
        <name evidence="8" type="ORF">K11D2.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CBM41211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001251914.1">
        <property type="nucleotide sequence ID" value="NM_001264985.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFR1"/>
    <dbReference type="SMR" id="D7SFR1"/>
    <dbReference type="PeptideAtlas" id="D7SFR1"/>
    <dbReference type="GeneID" id="173121"/>
    <dbReference type="AGR" id="WB:WBGene00006829"/>
    <dbReference type="CTD" id="173121"/>
    <dbReference type="WormBase" id="K11D2.3c">
        <property type="protein sequence ID" value="CE45092"/>
        <property type="gene ID" value="WBGene00006829"/>
        <property type="gene designation" value="unc-101"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_0_0_1"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006829">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFR1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09258">
        <property type="entry name" value="AP-1_Mu1A_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="5">
        <location>
            <begin position="18"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBM41211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="K11D2.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="D7SFR1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31015" checksum="DCAE84217030BED7" modified="2010-08-10" version="1">MAVTNAVSWRSEGIKYRKNEVFLDVIESVNMLASANGTVLQSEIVGSVKMRVYLTGMPELRLGLNDKVLFEGSGRGKSKSVELEDVKFHQCVRLSRFDTDRTISFIPPDGAFELMSYRLTTVVKPLIWIETSIERHSHSRVSFIIKAKSQFKRRSTANNVEIIIPVPSDADSPKFKTSIGSVKYTPEQSAFVWTIKNFPGGKEYLLTAHLSLPSVMSEESEGRPPIKVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGEYEMRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHB1</accession>
    <name>E0AHB1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C34E11.2</name>
        <name evidence="3" type="ORF">CELE_C34E11.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CBW44363.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359750.1">
        <property type="nucleotide sequence ID" value="NM_001373516.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHB1"/>
    <dbReference type="SMR" id="E0AHB1"/>
    <dbReference type="STRING" id="6239.C34E11.2a.1"/>
    <dbReference type="PaxDb" id="6239-C34E11.2a"/>
    <dbReference type="GeneID" id="181359"/>
    <dbReference type="AGR" id="WB:WBGene00007935"/>
    <dbReference type="CTD" id="181359"/>
    <dbReference type="WormBase" id="C34E11.2a">
        <property type="protein sequence ID" value="CE53314"/>
        <property type="gene ID" value="WBGene00007935"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S19I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5973987at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007935">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHB1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000006">
        <property type="entry name" value="Expansion, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
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        </source>
    </evidence>
    <sequence length="240" mass="27365" checksum="B8FEA97FF229A457" modified="2010-10-05" version="1">MNFEPYSVVLESDNPDCPIIKIPHYANGNENGNGNGIMKTPQRETVVSLGFTEDPIPPNSYCCNSCHIQKACRAVAVFAFLGFIINLVLYFMGISKLGLNGYLEAFLLIFDCISLLTLFCGVSKQRSGLLKPYLFYNVIWNFGMIILFLVFVYHMLKGTSDVSRNILDNLKALRSNPDEYHFRSRESVTTAILVTLGVMAAMSFVIVINCIFLHVVYRTFQFFAYQEDKKREEMDKKERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHB6</accession>
    <name>E0AHB6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class U</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">sru-36</name>
        <name evidence="2" type="ORF">CELE_R07B5.6</name>
        <name evidence="4" type="ORF">R07B5.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256144.1">
        <property type="nucleotide sequence ID" value="NM_001269215.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHB6"/>
    <dbReference type="GeneID" id="187653"/>
    <dbReference type="AGR" id="WB:WBGene00005699"/>
    <dbReference type="CTD" id="187653"/>
    <dbReference type="WormBase" id="R07B5.6b">
        <property type="protein sequence ID" value="CE45284"/>
        <property type="gene ID" value="WBGene00005699"/>
        <property type="gene designation" value="sru-36"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5844399at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHB6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003839">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sru"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46045:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46045">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS U-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10322">
        <property type="entry name" value="7TM_GPCR_Sru"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBW44389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R07B5.6b"/>
        </source>
    </evidence>
    <sequence length="258" mass="30103" checksum="494B28AEA20A2D07" modified="2010-10-05" version="1">MEESIHGMQEYQSFQYKFTFSTTQAVFQLTYMTPTIVVMLKIFMSFRGPSHWNSAHTMNHHIYVIIMLYFLFICSKIMIISLPLLFLIPLCCTSFMIPALGYCRQMGSPLNYGATYIYYSGGWDGWRNSYIHLVMSIVMCSLTILCSVVMLFKLRQSVFSNSSARTKEQSKRAESSLSFTMISFIIPFINNTMLTIVYLTFPGWVYHMMIFRPFGNDCETVMMPWILYMTHPMFRRKRTISQSTAVTTIPRMNSPIMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHB9</accession>
    <name>E0AHB9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_F14D7.6</name>
        <name evidence="8 10" type="ORF">F14D7.6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHB9"/>
    <dbReference type="SMR" id="E0AHB9"/>
    <dbReference type="AGR" id="WB:WBGene00008793"/>
    <dbReference type="WormBase" id="F14D7.6b">
        <property type="protein sequence ID" value="CE45282"/>
        <property type="gene ID" value="WBGene00008793"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1373337_0_0_1"/>
    <dbReference type="OrthoDB" id="370281at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008793">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHB9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBW44369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F14D7.6b"/>
        </source>
    </evidence>
    <sequence length="199" mass="22394" checksum="6693773F852DA63C" modified="2010-10-05" version="1">MVRVSFTSRSGTMTLDENENEKNEVSASDLLDERQTDWRSMWISIFLQFVVGIQVSVYYMSMWPYLQKLDKTADVDFLGWIVASCNIGSTISNPIYGYWNQKTMSVKMPVIIGFMIAALAQTWYGLLSIFPHAKWFMLSARVLTGFGVGNIAALRIYAATASTPRDRMKAISYGTGGHFSHRLGRMVGSLDLFLLICSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHC0</accession>
    <name>E0AHC0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_F14D7.6</name>
        <name evidence="6 8" type="ORF">F14D7.6</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256577.1">
        <property type="nucleotide sequence ID" value="NM_001269648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHC0"/>
    <dbReference type="SMR" id="E0AHC0"/>
    <dbReference type="GeneID" id="184466"/>
    <dbReference type="AGR" id="WB:WBGene00008793"/>
    <dbReference type="CTD" id="184466"/>
    <dbReference type="WormBase" id="F14D7.6c">
        <property type="protein sequence ID" value="CE45258"/>
        <property type="gene ID" value="WBGene00008793"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027024_3_0_1"/>
    <dbReference type="OrthoDB" id="370281at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008793">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHC0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBW44370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F14D7.6c"/>
        </source>
    </evidence>
    <sequence length="157" mass="17425" checksum="6A84B2BCA397F9BD" modified="2010-10-05" version="1">MLIGLGFFLLYQVFMYPWGFYSGPLDYLPDGKDTDVAGGCYQSYKWCQWTTRVPLPVYLICFIVFFGIAFPFVESPSAALYSEILGPRKQGNMQGLFSLGGSLAPVIGSLSSTALFQASGFRYVMVYQAVVLVIGALLIGVFYKRLVPLKLKSIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHC1</accession>
    <name>E0AHC1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">nmr-2</name>
        <name evidence="19" type="ORF">CELE_T01C3.10</name>
        <name evidence="21" type="ORF">T01C3.10</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256641.1">
        <property type="nucleotide sequence ID" value="NM_001269712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHC1"/>
    <dbReference type="SMR" id="E0AHC1"/>
    <dbReference type="GeneID" id="180002"/>
    <dbReference type="AGR" id="WB:WBGene00003775"/>
    <dbReference type="CTD" id="180002"/>
    <dbReference type="WormBase" id="T01C3.10b">
        <property type="protein sequence ID" value="CE45268"/>
        <property type="gene ID" value="WBGene00003775"/>
        <property type="gene designation" value="nmr-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002039_3_0_1"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003775">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHC1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000199">
        <property type="entry name" value="Glutamate receptor ionotropic, NMDA 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000155">
        <property type="entry name" value="Glutamate receptor ionotropic, NMDA 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="18">
        <location>
            <begin position="60"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="382"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="14">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="14">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="244"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBW44390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WormBase" id="T01C3.10b"/>
        </source>
    </evidence>
    <sequence length="429" mass="48863" checksum="708E02BA2D75D02C" modified="2010-10-05" version="1">MHNKADMCVTSLKLNSERARDIDFSLPFLDTGISIIVKIRSGVLSPTAFLEPFEYSTWVIILFVCIHVAAISIFLFEWVSPYSFNMQKYPPPEHKFSLFRSYWLVWATLFSASVSTDVPKSTVSRLMALVWAAFGLTFLAVYTANLAAFMITRVQYYDLSGIHDPMLNFPHDQKPPFRFGTVDGGNTHETMKRNWHKMHEYVKHNKYFRMNISAGIEAVKNEELDAFIYDAVVLDYWAGKDANCALMTVGKWASMTGYGIGFPKNSPHTSLVNHYMLQYQQKGDLERLQNFWLTGACTPDSHSQTQSAPLGIENFLSAFVLLAGGIIVSVIVLGFEHIYCMHLRKPLQKIDPNGWCGIISMAMGKSLTFTEAVDRVQEWRSRTQSLASTNSPQLKRRRSANLRPTEEPFNQDLNPPRRSPRFLQVETNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHC2</accession>
    <name>E0AHC2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">svh-5</name>
        <name evidence="9" type="synonym">tag-97</name>
        <name evidence="9" type="ORF">C33A11.4</name>
        <name evidence="7" type="ORF">CELE_C33A11.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CBW44362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379521.1">
        <property type="nucleotide sequence ID" value="NM_001392898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHC2"/>
    <dbReference type="SMR" id="E0AHC2"/>
    <dbReference type="GeneID" id="181627"/>
    <dbReference type="AGR" id="WB:WBGene00006462"/>
    <dbReference type="CTD" id="181627"/>
    <dbReference type="WormBase" id="C33A11.4b">
        <property type="protein sequence ID" value="CE45227"/>
        <property type="gene ID" value="WBGene00006462"/>
        <property type="gene designation" value="svh-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553467_0_0_1"/>
    <dbReference type="OrthoDB" id="8196042at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006462">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHC2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08757">
        <property type="entry name" value="SAM_PNT_ESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000784">
        <property type="entry name" value="Protein CBR-TAG-97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000118">
        <property type="entry name" value="Protein CBR-TAG-97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF190">
        <property type="entry name" value="ETS-DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="6">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="302"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBW44362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C33A11.4b"/>
        </source>
    </evidence>
    <sequence length="401" mass="45306" checksum="1E73CE8F1F1AA006" modified="2010-10-05" version="1">MCIPKLLQEISNNKVLRTRMNNTAYKPIPNNEKVDLARFRVKDPNEWLVDDVVAWMLDVAKRHNIPFEEMNMHKFAMLSGQEMLTMSERCFIERDPVFGNLIFNEFRKTLENSEDTTLDTVIGPFVDDEIATTSAPPTIVDMTSLGLQPMISSITCTIQPPLQHPTPHLAPLPVMQHQLNNLSSLTQVLSQQTFNTTILTPQQTANAVQSLNQSLASSIAAGLTSSLSPLGVNYQLSSRLNPASPLLSAPIQPKLSPMLKYSCTINTEYEVPEERSAESSDLKIKKNKDGKPRKRSQHTKGNKLWEFIRDALKDPSTCPSVVRWEDPIEGVFRIVESEKLARLWGARKNNEKMTYEKLSRAMRTYYEKQILVPVPKTGLYPKKLVYKFGPGAHGWENVKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHC3</accession>
    <name>E0AHC3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UNC-76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">unc-76</name>
        <name evidence="7" type="ORF">C01G10.11</name>
        <name evidence="5" type="ORF">CELE_C01G10.11</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zygin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256646.1">
        <property type="nucleotide sequence ID" value="NM_001269717.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHC3"/>
    <dbReference type="SMR" id="E0AHC3"/>
    <dbReference type="PeptideAtlas" id="E0AHC3"/>
    <dbReference type="GeneID" id="180014"/>
    <dbReference type="AGR" id="WB:WBGene00006808"/>
    <dbReference type="CTD" id="31179"/>
    <dbReference type="WormBase" id="C01G10.11c">
        <property type="protein sequence ID" value="CE45264"/>
        <property type="gene ID" value="WBGene00006808"/>
        <property type="gene designation" value="unc-76"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041596_2_0_1"/>
    <dbReference type="OrthoDB" id="7959977at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006808">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHC3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099641">
        <property type="term" value="P:anterograde axonal protein transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="SynGO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007413">
        <property type="term" value="P:axonal fasciculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030516">
        <property type="term" value="P:regulation of axon extension"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050807">
        <property type="term" value="P:regulation of synapse organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011680">
        <property type="entry name" value="FEZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394:SF12">
        <property type="entry name" value="LD08195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394">
        <property type="entry name" value="ZYGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07763">
        <property type="entry name" value="FEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBW44355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C01G10.11c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="E0AHC3"/>
        </source>
    </evidence>
    <sequence length="287" mass="32247" checksum="810CF3375EEAFEFE" modified="2010-10-05" version="1">MNESQTWWTLTGNFGNIQPLDFGTSSICKKMAAALDSDSLKDDASTRRSMTNSDDEDLLRQQMDVHQMIGHHHGSTDTGGETPPQTADQVIEEIDEMLQSCDFTGSMMTDRTMESVDSMYSSMRSPFPSSIQSSDADIKLRSAQALVSNPDNLQELSYSKLVTLCAEMEQLIRVYNESLVDELAHRDELDYEKEMKNSFISLLLAIQNKRRVYANDRKRKVGKASDASQLPQYLTATIPYNDHQHIDNASIASLIKILRAIHDDNTTVPTLLTDYILTHVCPKNISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHC4</accession>
    <name>E0AHC4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UNC-76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">unc-76</name>
        <name evidence="6" type="ORF">C01G10.11</name>
        <name evidence="4" type="ORF">CELE_C01G10.11</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zygin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256647.1">
        <property type="nucleotide sequence ID" value="NM_001269718.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHC4"/>
    <dbReference type="SMR" id="E0AHC4"/>
    <dbReference type="PeptideAtlas" id="E0AHC4"/>
    <dbReference type="GeneID" id="180014"/>
    <dbReference type="AGR" id="WB:WBGene00006808"/>
    <dbReference type="CTD" id="31179"/>
    <dbReference type="WormBase" id="C01G10.11d">
        <property type="protein sequence ID" value="CE45251"/>
        <property type="gene ID" value="WBGene00006808"/>
        <property type="gene designation" value="unc-76"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041596_2_0_1"/>
    <dbReference type="OrthoDB" id="7959977at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006808">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHC4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099641">
        <property type="term" value="P:anterograde axonal protein transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="SynGO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007413">
        <property type="term" value="P:axonal fasciculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030516">
        <property type="term" value="P:regulation of axon extension"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050807">
        <property type="term" value="P:regulation of synapse organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011680">
        <property type="entry name" value="FEZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394:SF12">
        <property type="entry name" value="LD08195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394">
        <property type="entry name" value="ZYGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07763">
        <property type="entry name" value="FEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBW44356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C01G10.11d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="E0AHC4"/>
        </source>
    </evidence>
    <sequence length="238" mass="26868" checksum="17FBE22AF9E0D68C" modified="2010-10-05" version="1">MTNSDDEDLLRQQMDVHQMIGHHHGSTDTGGETPPQTADQVIEEIDEMLQSCDFTGSMMTDRTMESVDSMYSSMRSPFPSSIQSSDADIKLRSAQALVSNPDNLQELSYSKLVTLCAEMEQLIRVYNESLVDELAHRDELDYEKEMKNSFISLLLAIQNKRRVYANDRKRKVGKASDASQLPQYLTATIPYNDHQHIDNASIASLIKILRAIHDDNTTVPTLLTDYILTHVCPKNISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHC5</accession>
    <name>E0AHC5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MitMem_reg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">unc-76</name>
        <name evidence="6" type="ORF">C01G10.11</name>
        <name evidence="4" type="ORF">CELE_C01G10.11</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zygin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256648.1">
        <property type="nucleotide sequence ID" value="NM_001269719.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHC5"/>
    <dbReference type="SMR" id="E0AHC5"/>
    <dbReference type="PeptideAtlas" id="E0AHC5"/>
    <dbReference type="GeneID" id="180014"/>
    <dbReference type="AGR" id="WB:WBGene00006808"/>
    <dbReference type="CTD" id="31179"/>
    <dbReference type="WormBase" id="C01G10.11e">
        <property type="protein sequence ID" value="CE45280"/>
        <property type="gene ID" value="WBGene00006808"/>
        <property type="gene designation" value="unc-76"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041596_2_0_1"/>
    <dbReference type="OrthoDB" id="7959977at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006808">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHC5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099641">
        <property type="term" value="P:anterograde axonal protein transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="SynGO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007413">
        <property type="term" value="P:axonal fasciculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030516">
        <property type="term" value="P:regulation of axon extension"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050807">
        <property type="term" value="P:regulation of synapse organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011680">
        <property type="entry name" value="FEZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394:SF12">
        <property type="entry name" value="LD08195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394">
        <property type="entry name" value="ZYGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07763">
        <property type="entry name" value="FEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBW44357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C01G10.11e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="E0AHC5"/>
        </source>
    </evidence>
    <sequence length="120" mass="13810" checksum="EEED439C809403D7" modified="2010-10-05" version="1">MEQLIRVYNESLVDELAHRDELDYEKEMKNSFISLLLAIQNKRRVYANDRKRKVGKASDASQLPQYLTATIPYNDHQHIDNASIASLIKILRAIHDDNTTVPTLLTDYILTHVCPKNISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHC7</accession>
    <name>E0AHC7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuronal small secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nssp-71</name>
        <name evidence="4" type="ORF">C25D7.15</name>
        <name evidence="2" type="ORF">CELE_C25D7.15</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256644.1">
        <property type="nucleotide sequence ID" value="NM_001269715.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHC7"/>
    <dbReference type="SMR" id="E0AHC7"/>
    <dbReference type="GeneID" id="3565209"/>
    <dbReference type="AGR" id="WB:WBGene00007722"/>
    <dbReference type="CTD" id="3565209"/>
    <dbReference type="WormBase" id="C25D7.15b">
        <property type="protein sequence ID" value="CE45287"/>
        <property type="gene ID" value="WBGene00007722"/>
        <property type="gene designation" value="nssp-71"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2040237_0_0_1"/>
    <dbReference type="OrthoDB" id="5809871at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007722">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHC7">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBW44361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C25D7.15b"/>
        </source>
    </evidence>
    <sequence length="78" mass="8484" checksum="12A0E7CE2AEC4EE3" modified="2010-10-05" version="1">MKFDCKVNNPKKFRQTTKGCNDPGNALVACTQLMTQCQAQGGTGQCYTCNGDYCNSSPTSFSILISIVVPAISYFLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHC8</accession>
    <name>E0AHC8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_D2023.3</name>
        <name evidence="3 5" type="ORF">D2023.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256375.1">
        <property type="nucleotide sequence ID" value="NM_001269446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHC8"/>
    <dbReference type="SMR" id="E0AHC8"/>
    <dbReference type="PeptideAtlas" id="E0AHC8"/>
    <dbReference type="GeneID" id="183945"/>
    <dbReference type="AGR" id="WB:WBGene00008407"/>
    <dbReference type="CTD" id="183945"/>
    <dbReference type="WormBase" id="D2023.3b">
        <property type="protein sequence ID" value="CE45232"/>
        <property type="gene ID" value="WBGene00008407"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108631_0_0_1"/>
    <dbReference type="OrthoDB" id="5978493at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008407">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHC8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043541">
        <property type="entry name" value="SYT14/14L/16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129:SF2">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBW44366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="D2023.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="E0AHC8"/>
        </source>
    </evidence>
    <sequence length="173" mass="19087" checksum="3892801F37BC2D72" modified="2010-10-05" version="1">MHSNGISRGHNGDSRRSSMVDATGRFCSQPMSGSPEILVGLCYDDKHEVVSVCIEKASSLGSDTAHPPDSFIRIIGLDEFSTELSRHKTDTVKHSTQPVYSHHCTMRFSKDKVETSTVRVEVWTVTGILRRKVQIGSISIGFASSTPDANEHWQQMMQGAGITVSKWHAIQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHD4</accession>
    <name>E0AHD4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">amx-3</name>
        <name evidence="2" type="ORF">CELE_F25C8.2</name>
        <name evidence="4" type="ORF">F25C8.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256964.1">
        <property type="nucleotide sequence ID" value="NM_001270035.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHD4"/>
    <dbReference type="SMR" id="E0AHD4"/>
    <dbReference type="GeneID" id="184919"/>
    <dbReference type="KEGG" id="cel:CELE_F25C8.2"/>
    <dbReference type="AGR" id="WB:WBGene00000139"/>
    <dbReference type="CTD" id="184919"/>
    <dbReference type="WormBase" id="F25C8.2b">
        <property type="protein sequence ID" value="CE45241"/>
        <property type="gene ID" value="WBGene00000139"/>
        <property type="gene designation" value="amx-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_2_3_1"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000139">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHD4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF407">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBW44374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F25C8.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="E0AHD4"/>
        </source>
    </evidence>
    <sequence length="365" mass="41925" checksum="D01B58726C8C2087" modified="2010-10-05" version="1">MLDQDNSITLVNGHLVPKKILDKFNDYIRYLNVALYEKSIKINQLSVENEINNQFIEFLRDVPENDHEIYESLINVYKNYFQTEWSSPVGELSLSNLSIWDDGTEEEDSAVLNKQGFYEILKDFRSKIPAGNIRLNCEVINVKEEENIMVTLKNGEVLHFDACIVTCSLGYLKKHHKTLFTPQLTSVKQDAINRMGFGNNLKVFLEYSDSWWNSLNTILILTHGENEDFMVFQPSSWAENILLCWIAGSGPKKICDKTDFELKILLDTHLHDQLKNYLDVKASVKIYRKNWINDEFTLGSYSYLTPGQIVGEDICILAQPVLKDNNPVICFAGEHTDSTMYQTTVGAVRSGLREASRISEHTFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHD5</accession>
    <name>E0AHD5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F26F2.10</name>
        <name evidence="2 4" type="ORF">F26F2.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256930.1">
        <property type="nucleotide sequence ID" value="NM_001270001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHD5"/>
    <dbReference type="GeneID" id="13218867"/>
    <dbReference type="AGR" id="WB:WBGene00138719"/>
    <dbReference type="CTD" id="13218867"/>
    <dbReference type="WormBase" id="F26F2.10b">
        <property type="protein sequence ID" value="CE45252"/>
        <property type="gene ID" value="WBGene00138719"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2063610_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00138719">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHD5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002601">
        <property type="entry name" value="C6_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01681">
        <property type="entry name" value="C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C6" evidence="1">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBW44375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F26F2.10b"/>
        </source>
    </evidence>
    <sequence length="72" mass="7610" checksum="94D22E2C727857CA" modified="2010-10-05" version="1">MGTNADGCSTSKITCKQEQGQTCTLSIMGQPLTEKSSINLQCNNDGTWSDIGDEALNNVNHVSCTCTPEPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHD6</accession>
    <name>E0AHD6_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">CUB_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">cld-9</name>
        <name evidence="1" type="ORF">CELE_F35E12.8</name>
        <name evidence="3" type="ORF">F35E12.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256544.1">
        <property type="nucleotide sequence ID" value="NM_001269615.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHD6"/>
    <dbReference type="GeneID" id="179869"/>
    <dbReference type="AGR" id="WB:WBGene00009432"/>
    <dbReference type="CTD" id="179869"/>
    <dbReference type="WormBase" id="F35E12.8b">
        <property type="protein sequence ID" value="CE45259"/>
        <property type="gene ID" value="WBGene00009432"/>
        <property type="gene designation" value="cld-9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022349_3_0_1"/>
    <dbReference type="OrthoDB" id="5847896at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009432">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHD6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21447:SF5">
        <property type="entry name" value="CUB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21447">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBW44376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F35E12.8b"/>
        </source>
    </evidence>
    <sequence length="183" mass="19617" checksum="5F323C296A54F49C" modified="2010-10-05" version="1">MPQMIPAKLFSMVTLGPELSLTLSSTADNWLTPYNGRKGSIFSSSLWTPEATSGYNHTFVSTNVMTFTFNIKKAIIHQAGEQMHVQVGLPGFKPSSLTFTNSVSDQSRLANGTYLMIEYIGDSTSSSSIVTFEMANANGEQGTSYLPSKSTSSSIQSTTKSGLKNTFGIASGISLLIALFLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>E0AHD7</accession>
    <name>E0AHD7_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">CUB_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F35E12.9</name>
        <name evidence="1 3" type="ORF">F35E12.9</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBW44377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256542.1">
        <property type="nucleotide sequence ID" value="NM_001269613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E0AHD7"/>
    <dbReference type="GeneID" id="179867"/>
    <dbReference type="AGR" id="WB:WBGene00009433"/>
    <dbReference type="CTD" id="179867"/>
    <dbReference type="WormBase" id="F35E12.9c">
        <property type="protein sequence ID" value="CE45223"/>
        <property type="gene ID" value="WBGene00009433"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022349_2_0_1"/>
    <dbReference type="OrthoDB" id="5791243at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009433">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E0AHD7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21447:SF7">
        <property type="entry name" value="CUB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21447">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBW44377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F35E12.9c"/>
        </source>
    </evidence>
    <sequence length="352" mass="39302" checksum="52C434F5AE79E81E" modified="2010-10-05" version="1">MYIIHTGNITNVELYVSPTIARVNVVGVSGKSSFMLTYLYKSLEAYKQTIKKTGEYFPLSLVTGISYYTITSDNPNEKVVLSYAMRVGVNEDKLLAYYYVYDGDNINNATMIGNLDTIGGKITVSSGRSVTIVNFYGGTKSNSYALGNDASTVQGYDKYTVLMTSKGTTASGNMTSLATNGGLYTFICVDCSTFYYTQLRFDSMTPVSNRAYVTFQGMTPTHKKEKLIKYDMMTVTDKYFPQMMPSNIITLNVYLARVGFMFNNVNDDTQWKKAYDGRKGMIFSPNLWMSTPNSFSYEIRDDSQMYNFAVTINKMSFPASSDKMTLIIGPTTGNPTLNNMYPRDQSSTGKVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-04-07" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>G5EEM0-2</accession>
    <name>NH114_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform d of Nuclear hormone receptor 114</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nhr-114</name>
        <name evidence="5" type="ORF">Y45G5AM.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2003" name="Comp. Funct. Genomics" volume="4" first="479" last="491">
            <title>Proteins interacting with Caenorhabditis elegans Galpha subunits.</title>
            <authorList>
                <person name="Cuppen E."/>
                <person name="van der Linden A.M."/>
                <person name="Jansen G."/>
                <person name="Plasterk R.H."/>
            </authorList>
            <dbReference type="PubMed" id="18629017"/>
            <dbReference type="DOI" id="10.1002/cfg.318"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2005" name="J. Mol. Evol." volume="60" first="577" last="586">
            <title>Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes.</title>
            <authorList>
                <person name="Robinson-Rechavi M."/>
                <person name="Maina C.V."/>
                <person name="Gissendanner C.R."/>
                <person name="Laudet V."/>
                <person name="Sluder A."/>
            </authorList>
            <dbReference type="PubMed" id="15983867"/>
            <dbReference type="DOI" id="10.1007/s00239-004-0175-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2013" name="Curr. Biol." volume="23" first="607" last="613">
            <title>Fertility and germline stem cell maintenance under different diets requires nhr-114/HNF4 in C. elegans.</title>
            <authorList>
                <person name="Gracida X."/>
                <person name="Eckmann C.R."/>
            </authorList>
            <dbReference type="PubMed" id="23499532"/>
            <dbReference type="DOI" id="10.1016/j.cub.2013.02.034"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2020" name="Elife" volume="9" first="0" last="0">
            <title>C. elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor.</title>
            <authorList>
                <person name="Giese G.E."/>
                <person name="Walker M.D."/>
                <person name="Ponomarova O."/>
                <person name="Zhang H."/>
                <person name="Li X."/>
                <person name="Minevich G."/>
                <person name="Walhout A.J."/>
            </authorList>
            <dbReference type="PubMed" id="33016879"/>
            <dbReference type="DOI" id="10.7554/elife.60259"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EEM0-2</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060919"/>
        </isoform>
        <isoform>
            <id>G5EEM0-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001317845.1">
        <property type="nucleotide sequence ID" value="NM_001330839.3"/>
    </dbReference>
    <dbReference type="WormBase" id="Y45G5AM.1d">
        <property type="protein sequence ID" value="CE51628"/>
        <property type="gene ID" value="WBGene00003704"/>
        <property type="gene designation" value="nhr-114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAO27833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAO39202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="Y45G5AM.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="Y45G5AM.1d"/>
        </source>
    </evidence>
    <sequence length="143" mass="16148" checksum="B727D3DE1C2F4AE7" modified="2011-12-14" version="1">MVPTSIVLQSQPAGLNRKKYQMLDLVLKPFRDLQLDATEFAAFKAVTFLNPDADISLPARKLVNNERVRITKQLYGYMAMKDDVDTAIERFARLVLMGTSMSKMACESKEAVWIADFFENIGFSAFARQLFFGDTTSVVAHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-07-01" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>O01760</accession>
    <name>O01760_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1691 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F55A12.2</name>
        <name evidence="2 4" type="ORF">F55A12.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD65433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T15194">
        <property type="entry name" value="T15194"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_740851.1">
        <property type="nucleotide sequence ID" value="NM_170864.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O01760"/>
    <dbReference type="PeptideAtlas" id="O01760"/>
    <dbReference type="GeneID" id="172185"/>
    <dbReference type="UCSC" id="F55A12.2d">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018863"/>
    <dbReference type="CTD" id="172185"/>
    <dbReference type="WormBase" id="F55A12.2a">
        <property type="protein sequence ID" value="CE29396"/>
        <property type="gene ID" value="WBGene00018863"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1533948_0_0_1"/>
    <dbReference type="OrthoDB" id="6234762at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018863">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O01760">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057591">
        <property type="entry name" value="TMEM126-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23408">
        <property type="entry name" value="TMEM126_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F55A12.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="O01760"/>
        </source>
    </evidence>
    <sequence length="175" mass="19251" checksum="443B9949EEF2897B" modified="2001-12-01" version="2">MSSADQAHLMSRLSSTWPFRDERRALTWPVHAGLVANCVTSSLIATRINSEMFLYDAKAKFFESIRKCPKSPFVFGVYSSGVTYFMLHQVLVTPKVYNELTPCPSCLVINSIAIGLLTGIALPMLATPYLAHYVLINREANTGGSSRAMPVVNNLLEFLTLGWEGISNAPNPLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-07-01" modified="2025-10-08" version="175" xmlns="https://uniprot.org/uniprot">
    <accession>O01776</accession>
    <name>O01776_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_ZC581.9</name>
        <name evidence="4 6" type="ORF">ZC581.9</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD64902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29772">
        <property type="entry name" value="T29772"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_491915.2">
        <property type="nucleotide sequence ID" value="NM_059514.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O01776"/>
    <dbReference type="SMR" id="O01776"/>
    <dbReference type="PaxDb" id="6239-ZC581.9"/>
    <dbReference type="GeneID" id="172385"/>
    <dbReference type="UCSC" id="ZC581.9">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022635"/>
    <dbReference type="CTD" id="172385"/>
    <dbReference type="WormBase" id="ZC581.9a">
        <property type="protein sequence ID" value="CE36351"/>
        <property type="gene ID" value="WBGene00022635"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020833_0_0_1"/>
    <dbReference type="OMA" id="FKQRNAR"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="PhylomeDB" id="O01776"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022635">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O01776">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF16">
        <property type="entry name" value="BLACK MATCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="758"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD64902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="ZC581.9a"/>
        </source>
    </evidence>
    <sequence length="827" mass="92975" checksum="19E783AE38117602" modified="2004-03-01" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>P34420-2</accession>
    <name>ESS2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Splicing factor ESS-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>ES2 similar protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ess-2</name>
        <name type="ORF">F42H10.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="Mamm. Genome" volume="7" first="639" last="643">
            <title>Cloning and comparative mapping of a gene from the commonly deleted region of DiGeorge and Velocardiofacial syndromes conserved in C. elegans.</title>
            <authorList>
                <person name="Rizzu P."/>
                <person name="Lindsay E.A."/>
                <person name="Taylor C."/>
                <person name="O'Donnell H."/>
                <person name="Levy A."/>
                <person name="Scambler P.J."/>
                <person name="Baldini A."/>
            </authorList>
            <dbReference type="PubMed" id="8703114"/>
            <dbReference type="DOI" id="10.1007/s003359900197"/>
        </citation>
        <scope>SIMILARITY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2014" name="Genetics" volume="198" first="1101" last="1115">
            <title>Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA splicing in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Noma K."/>
                <person name="Goncharov A."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="25194163"/>
            <dbReference type="DOI" id="10.1534/genetics.114.167841"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34420-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_015951"/>
        </isoform>
        <isoform>
            <id>P34420-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022580.1">
        <property type="nucleotide sequence ID" value="NM_001027409.6"/>
    </dbReference>
    <dbReference type="WormBase" id="F42H10.7a">
        <property type="protein sequence ID" value="CE00169"/>
        <property type="gene ID" value="WBGene00018371"/>
        <property type="gene designation" value="ess-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="25194163"/>
        </source>
    </evidence>
    <sequence length="529" mass="58285" checksum="BBBBF2C479BFE253" modified="2005-10-25" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-09-05" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q0PDJ7</accession>
    <name>Q0PDJ7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ntl-3</name>
        <name evidence="5" type="ORF">CELE_Y56A3A.1</name>
        <name evidence="7" type="ORF">Y56A3A.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAB07318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T19385">
        <property type="entry name" value="T19385"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001076653.1">
        <property type="nucleotide sequence ID" value="NM_001083184.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q0PDJ7"/>
    <dbReference type="SMR" id="Q0PDJ7"/>
    <dbReference type="PeptideAtlas" id="Q0PDJ7"/>
    <dbReference type="GeneID" id="176614"/>
    <dbReference type="UCSC" id="Y56A3A.1b.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003826"/>
    <dbReference type="CTD" id="176614"/>
    <dbReference type="WormBase" id="Y56A3A.1b">
        <property type="protein sequence ID" value="CE18516"/>
        <property type="gene ID" value="WBGene00003826"/>
        <property type="gene designation" value="ntl-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102322_0_0_1"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003826">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q0PDJ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000016">
        <property type="entry name" value="NOT-Like (Yeast CCR4/NOT complex component)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="4">
        <location>
            <begin position="72"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB07318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y56A3A.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q0PDJ7"/>
        </source>
    </evidence>
    <sequence length="198" mass="22681" checksum="FFFABB061369CDC7" modified="2006-09-05" version="1">MLGGMMSTDDPAAALQAALNMAAASQQAVATGPKRAHIPAWLGASPLGRTSMTQEFDGQLAALELACAKATFPLDSEKPRNYLSKVSFPVPSWYGQTAPNTSDSLEYYLRLAPDTLFFIFYYMEGTRAQLLAAKALKKLSWRFHTKYLTWFQRHEEPKQITDDYEQGTYVYFDFEKWSQRKKESFTFEYKFLEDKEFD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>Q17828-2</accession>
    <name>SUV3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of ATP-dependent RNA helicase SUV3 homolog, mitochondrial</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C08F8.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q17828-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q17828-2</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_060781"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001255542.1">
        <property type="nucleotide sequence ID" value="NM_001268613.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C08F8.2c">
        <property type="protein sequence ID" value="CE45714"/>
        <property type="gene ID" value="WBGene00007444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q8IYB8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C08F8.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C08F8.2c"/>
        </source>
    </evidence>
    <sequence length="438" mass="49136" checksum="86994882B98BBD7D" modified="2020-12-02" version="3" precursor="true">MLRDEQRGWAWTRALLGAAADEIHLCGEPAAIDIVKKLLEPIGETVEVRYYERKSPLAIADKAIESYSNIEPGDCIVCFSKRSIFFNSKKLEENGIKPAVIYGDLPPGTKLAQAAKFNDPDDECNVLVATDAIGMGLNLNIRRVIFNSCTRQTELLPTYAALQIAGRAGRFGTAYANGVATTMRKEDLGTLKAILSEKIEPIANVGIAPTYDQIETFSFHLPQASFVRLLDLFVSVCSVSDHFFICTVYDMRELAVLIDQIPLPLKVRYTFCTSPLNTEDKRTSAVFVKMARRFSTGQALTYEWLIDMLEWPPKPATTLNELSLLEQNYEILDQYMWLSMRFPDMLPDEPRVREASKHLDSMIQEGVESFMSLLSVGATESKAAGSSKSSEGKRENPSKSEREKPNKRSSILEALLKRADISEDDLEQLREELNKNKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>Q19564-2</accession>
    <name>OXDD2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of D-aspartate oxidase 2</fullName>
            <shortName>DASOX 2</shortName>
            <shortName evidence="3">DASPO 2</shortName>
            <shortName>DDO-2</shortName>
            <ecNumber evidence="1 2">1.4.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ddo-2</name>
        <name type="ORF">F18E3.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="FEBS J." volume="274" first="137" last="149">
            <title>Caenorhabditis elegans has two genes encoding functional D-aspartate oxidases.</title>
            <authorList>
                <person name="Katane M."/>
                <person name="Seida Y."/>
                <person name="Sekine M."/>
                <person name="Furuchi T."/>
                <person name="Homma H."/>
            </authorList>
            <dbReference type="PubMed" id="17140416"/>
            <dbReference type="DOI" id="10.1111/j.1742-4658.2006.05571.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Biochimie" volume="92" first="1371" last="1378">
            <title>Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment.</title>
            <authorList>
                <person name="Katane M."/>
                <person name="Saitoh Y."/>
                <person name="Hanai T."/>
                <person name="Sekine M."/>
                <person name="Furuchi T."/>
                <person name="Koyama N."/>
                <person name="Nakagome I."/>
                <person name="Tomoda H."/>
                <person name="Hirono S."/>
                <person name="Homma H."/>
            </authorList>
            <dbReference type="PubMed" id="20603179"/>
            <dbReference type="DOI" id="10.1016/j.biochi.2010.06.021"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="Chem. Biodivers." volume="7" first="1424" last="1434">
            <title>Comparative characterization of three D-aspartate oxidases and one D-amino acid oxidase from Caenorhabditis elegans.</title>
            <authorList>
                <person name="Katane M."/>
                <person name="Saitoh Y."/>
                <person name="Seida Y."/>
                <person name="Sekine M."/>
                <person name="Furuchi T."/>
                <person name="Homma H."/>
            </authorList>
            <dbReference type="PubMed" id="20564561"/>
            <dbReference type="DOI" id="10.1002/cbdv.200900294"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
        <scope>STEREOSPECIFICITY</scope>
        <scope>COFACTOR</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Mol. Cell. Biol." volume="32" first="1967" last="1983">
            <title>Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Saitoh Y."/>
                <person name="Katane M."/>
                <person name="Kawata T."/>
                <person name="Maeda K."/>
                <person name="Sekine M."/>
                <person name="Furuchi T."/>
                <person name="Kobuna H."/>
                <person name="Sakamoto T."/>
                <person name="Inoue T."/>
                <person name="Arai H."/>
                <person name="Nakagawa Y."/>
                <person name="Homma H."/>
            </authorList>
            <dbReference type="PubMed" id="22393259"/>
            <dbReference type="DOI" id="10.1128/MCB.06513-11"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19564-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q19564-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_014357 VSP_014359 VSP_014358 VSP_014356"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="1.4.3.1" evidence="1 2"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="20564561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="20603179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="51" mass="6137" checksum="5DADC95508918047" modified="1996-11-01" version="1">MCQIFREHSVVVGSTKQDNRWDLEITDEDRNDILKRYIALHPGMRVRISFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-05-02" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q1WBU8</accession>
    <name>Q1WBU8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein O-GlcNAcase</fullName>
            <ecNumber evidence="6">3.2.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">oga-1</name>
        <name evidence="10" type="ORF">CELE_T20B5.3</name>
        <name evidence="12" type="ORF">T20B5.3</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="11952" last="11957">
            <title>Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer.</title>
            <authorList>
                <person name="Forsythe M.E."/>
                <person name="Love D.C."/>
                <person name="Lazarus B.D."/>
                <person name="Kim E.J."/>
                <person name="Prinz W.A."/>
                <person name="Ashwell G."/>
                <person name="Krause M.W."/>
                <person name="Hanover J.A."/>
            </authorList>
            <dbReference type="PubMed" id="16882729"/>
            <dbReference type="DOI" id="10.1073/pnas.0601931103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = N-acetyl-D-glucosamine + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:48876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:48892"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.169" evidence="6"/>
    <dbReference type="EMBL" id="DQ407522">
        <property type="protein sequence ID" value="ABD85014.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD68586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123183.1">
        <property type="nucleotide sequence ID" value="NM_001129711.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1WBU8"/>
    <dbReference type="SMR" id="Q1WBU8"/>
    <dbReference type="GeneID" id="181164"/>
    <dbReference type="KEGG" id="cel:CELE_T20B5.3"/>
    <dbReference type="UCSC" id="T20B5.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020596"/>
    <dbReference type="CTD" id="181164"/>
    <dbReference type="WormBase" id="T20B5.3a">
        <property type="protein sequence ID" value="CE41843"/>
        <property type="gene ID" value="WBGene00020596"/>
        <property type="gene designation" value="oga-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009837_0_0_1"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020596">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q1WBU8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102571">
        <property type="term" value="F:[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015929">
        <property type="term" value="F:hexosaminidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040024">
        <property type="term" value="P:dauer larval development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010561">
        <property type="term" value="P:negative regulation of glycoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.240:FF:000004">
        <property type="entry name" value="O-GlcNAc selective N-Acetyl-beta-D-glucosaminidase (O-GlcNAcase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000009">
        <property type="entry name" value="O-GlcNAcase BT_4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.240">
        <property type="entry name" value="STAT, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051822">
        <property type="entry name" value="Glycosyl_Hydrolase_84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="O-GlcNAcase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170">
        <property type="entry name" value="O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170:SF16">
        <property type="entry name" value="PROTEIN O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52009">
        <property type="entry name" value="GH84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH84" evidence="8">
        <location>
            <begin position="18"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABD85014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD68586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="T20B5.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="Q1WBU8"/>
        </source>
    </evidence>
    <sequence length="854" mass="97827" checksum="F6B7136F00D59B5D" modified="2006-05-02" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q22544-2</accession>
    <name>TSCT1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Protein tsct-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tsct-1</name>
        <name evidence="2" type="synonym">txt-21</name>
        <name evidence="2" type="ORF">T18D3.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q22544-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_061798"/>
        </isoform>
        <isoform>
            <id>Q22544-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_061797"/>
        </isoform>
        <isoform>
            <id>Q22544-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001368132.1">
        <property type="nucleotide sequence ID" value="NM_001381118.1"/>
    </dbReference>
    <dbReference type="WormBase" id="T18D3.7b">
        <property type="protein sequence ID" value="CE47596"/>
        <property type="gene ID" value="WBGene00011824"/>
        <property type="gene designation" value="tsct-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T18D3.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T18D3.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T18D3.7c"/>
        </source>
    </evidence>
    <sequence length="255" mass="27887" checksum="84B5FFBDDE3CB869" modified="2023-02-22" version="3">MSTTSNEASVIEVVPPNANCDKPKKKFQVVPVPGEFTRGRWKVIDTRFGSAMGEFGNYPPEDEYKMIVTSKNNVITVRKKFPRPTTVTSAPILGAEEADSIRVLQKSQPRFEQVPVTNQIKILIMDPETAVVTAGNTGSTASEVGTDFALTNDMTSSPSSVALLSGDPTKMEDSAKLATATSNTVVAIDNKIVQAMDLVKTHLTFAVREEVETLRTTITDLEARLNALREENRLLRENVSPEVLAFITANKQLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2026-01-28" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>Q6A4Q6</accession>
    <name>Q6A4Q6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_W02B12.12</name>
        <name evidence="10 12" type="ORF">W02B12.12</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAH10788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022386.1">
        <property type="nucleotide sequence ID" value="NM_001027215.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6A4Q6"/>
    <dbReference type="SMR" id="Q6A4Q6"/>
    <dbReference type="GeneID" id="174755"/>
    <dbReference type="UCSC" id="W02B12.12b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012207"/>
    <dbReference type="CTD" id="174755"/>
    <dbReference type="WormBase" id="W02B12.12b">
        <property type="protein sequence ID" value="CE37051"/>
        <property type="gene ID" value="WBGene00012207"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012207">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6A4Q6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001919">
        <property type="entry name" value="Protein CBR-TWK-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="94"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH10788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="W02B12.12b"/>
        </source>
    </evidence>
    <sequence length="359" mass="41235" checksum="BCF4F4DFEE72E5E3" modified="2004-09-13" version="1">MTSEEPTRAQWSSREDRENQPPMPGSMYTKHSTYSTSKHPTTHTRTSYMPSKSSQHHHPASSSHHNHHRKRSDATKRYAIEDFRQAFARKGMDLDTSNKLGRGKYSKVYKAFDRNNNRVVAVKAIDTQELTTDVKMKFLPRELSCWRKLKNPFVVGLHAQYEAQSMIFLTMEYGSQGDLLRYVQEHGGIHEQKAGLFMSQLIRGLQFMHSINIAHRDIKLENIILFDNCVKLSDFGFVRKMDESALSSTFCGSKSYSAPELLRGIVYNPFLSDVWSLGVVGFVMVTNRMPFDEKKPNNVIVELQRNRQYVIPHSVFLSTSCISSFESMMAFDTRNRPTSTDCLALPWITPHIVMDRHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q6AW03</accession>
    <name>Q6AW03_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dimethylglycine dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_Y37E3.17</name>
        <name evidence="6 8" type="ORF">Y37E3.17</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD73438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021746.1">
        <property type="nucleotide sequence ID" value="NM_001026575.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6AW03"/>
    <dbReference type="SMR" id="Q6AW03"/>
    <dbReference type="STRING" id="6239.Y37E3.17b.1"/>
    <dbReference type="PaxDb" id="6239-Y37E3.17b"/>
    <dbReference type="PeptideAtlas" id="Q6AW03"/>
    <dbReference type="GeneID" id="171775"/>
    <dbReference type="UCSC" id="Y37E3.17b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021355"/>
    <dbReference type="CTD" id="171775"/>
    <dbReference type="WormBase" id="Y37E3.17b">
        <property type="protein sequence ID" value="CE37062"/>
        <property type="gene ID" value="WBGene00021355"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NGWERPN"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="PhylomeDB" id="Q6AW03"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021355">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6AW03">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="402"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="458"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="761"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD73438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y37E3.17b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q6AW03"/>
        </source>
    </evidence>
    <sequence length="837" mass="92550" checksum="7099A846DFDBBA12" modified="2004-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q6AW09</accession>
    <name>Q6AW09_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc carboxypeptidase A 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CELE_Y47G6A.19</name>
        <name evidence="15 17" type="ORF">Y47G6A.19</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD72563.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6AW09"/>
    <dbReference type="SMR" id="Q6AW09"/>
    <dbReference type="MEROPS" id="M14.A23"/>
    <dbReference type="PeptideAtlas" id="Q6AW09"/>
    <dbReference type="UCSC" id="Y47G6A.19b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021645"/>
    <dbReference type="WormBase" id="Y47G6A.19b">
        <property type="protein sequence ID" value="CE48428"/>
        <property type="gene ID" value="WBGene00021645"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021645">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6AW09">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000002">
        <property type="entry name" value="Carboxypeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000056">
        <property type="entry name" value="Zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF131">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004271731" description="Zinc carboxypeptidase A 1" evidence="13">
        <location>
            <begin position="18"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="133"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD72563.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="Y47G6A.19b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="Q6AW09"/>
        </source>
    </evidence>
    <sequence length="476" mass="54627" checksum="5D9CF019A30ADDDE" modified="2013-10-16" version="2">MILRVILALLIAVHSSCQEHGAFKVFRVLPTTNQQLLQMIRLFETADTDRADFWHAPSVVNGTVDIMVAPEHTDQFRQYLEKHGYTFQVAIDDLHKLLIEKEGNLSTHSNDDAFFLKRLHDDVGFHSRLRMGEYYSYSVLSTWLERIAENMPDIAKLIKVGTTIEGRDILGLKFGKDTPDKKIVVIDAGIHAREWAAIHTASYFINLIVNGREEDPQIQNYLDNIVLYIIPVLNPDGYEYTRTDKTNPRARMWRKSRSPKACAFDGVRNSCCMGVDLNRNFDFRFSEIGASRYPCSEIYHGPSAFSEPESKAYSQFLTSLKGRLEAYITLHSYSQLWIYSYSHRKFTYAPDIEETRRVAAKAVQELGRMYGTKYRHGTGPEIIYAFSGGSTDWAKETLKIKYSYTIELRPGYEEWNGFVLDKNQLIPTAKETWAGVTVVLDEVTNQWKSSRAIRRRNRKIVSGQTATLSRKSGRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-09-13" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q6AW19</accession>
    <name>Q6AW19_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y110A7A.9</name>
        <name evidence="3 5" type="ORF">Y110A7A.9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD66200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6AW19"/>
    <dbReference type="SMR" id="Q6AW19"/>
    <dbReference type="UCSC" id="Y110A7A.9b.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022459"/>
    <dbReference type="WormBase" id="Y110A7A.9b">
        <property type="protein sequence ID" value="CE37057"/>
        <property type="gene ID" value="WBGene00022459"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318149_0_0_1"/>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022459">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6AW19">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002398">
        <property type="entry name" value="Protein CBG10826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003670">
        <property type="entry name" value="Protein CBG10826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057853">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23752">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR11 second beta-propeller" evidence="2">
        <location>
            <begin position="270"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD66200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y110A7A.9b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q6AW19"/>
        </source>
    </evidence>
    <sequence length="908" mass="101861" checksum="0232AFF2384E7118" modified="2004-09-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2025-10-08" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I093</accession>
    <name>Q8I093_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F07C6.4</name>
        <name evidence="2 4" type="ORF">F07C6.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA93487.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T20549">
        <property type="entry name" value="T20549"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_502441.2">
        <property type="nucleotide sequence ID" value="NM_070040.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I093"/>
    <dbReference type="SMR" id="Q8I093"/>
    <dbReference type="DIP" id="DIP-26063N"/>
    <dbReference type="GeneID" id="178235"/>
    <dbReference type="UCSC" id="F07C6.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00008555"/>
    <dbReference type="CTD" id="178235"/>
    <dbReference type="WormBase" id="F07C6.4a">
        <property type="protein sequence ID" value="CE40408"/>
        <property type="gene ID" value="WBGene00008555"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_772175_0_0_1"/>
    <dbReference type="OrthoDB" id="10063592at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008555">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8I093">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047176">
        <property type="entry name" value="FRMD4A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079:SF2">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="1">
        <location>
            <begin position="14"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA93487.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F07C6.4a"/>
        </source>
    </evidence>
    <sequence length="396" mass="46120" checksum="94E24C746BB6655F" modified="2006-10-17" version="2">MDDPNRIVSASRRPKALIRLLDSQQIEVVLHSRLSVEDVLRLVAEKVDLSFPDSQYFCLGFSDNLNNFHWLDGSVILYDLVASTSNPKGTLTLSHHVRFFVDTIYEVQCASTAKLFFFDIHNQLARHELLVTSEDYFELVAILVSVFVPDCQEHTTAEAISRIMPMSHPPYILLKTDQSEVERRVFEKFRYYRRLPVGTGMISFIKLAEKSESYGYRMYEALNENNDKCILSIGYKGIYIYRRSRHQNLITPYLAYPWRVIDNLYYRDKKFSIEIREPKKNESSENVSDDVILINDRQLSEAFSHPTTQVSCGRRRSNNQQPRVLLFPFTCQTPLVCRTVWMSAIAQHRFFLERKELKKVSGDLLFFLPFLFRQSVLLLVFQSPFRPGGAHFAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IA55</accession>
    <name>Q8IA55_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine-rich glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F25E5.8</name>
        <name evidence="2 4" type="ORF">F25E5.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD65094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IA55"/>
    <dbReference type="PeptideAtlas" id="Q8IA55"/>
    <dbReference type="UCSC" id="F25E5.8b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017789"/>
    <dbReference type="WormBase" id="F25E5.8b">
        <property type="protein sequence ID" value="CE32876"/>
        <property type="gene ID" value="WBGene00017789"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1526550_0_0_1"/>
    <dbReference type="OrthoDB" id="5853970at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017789">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IA55">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37440">
        <property type="entry name" value="PROTEIN CBG17852-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37440:SF4">
        <property type="entry name" value="S39A8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD65094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F25E5.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q8IA55"/>
        </source>
    </evidence>
    <sequence length="176" mass="19560" checksum="BA8099F459C5595D" modified="2003-03-01" version="1">MKVPHVIAELVSEFSGFQHTPDFKASRSTGNFEEGSEEGTSGSHKPEEHHHKEHHGHSLYFGKHSGKKHLPPVVENDGDTHSNHSDVSGSGSSLKEKKHHGLTAHFKDLFHIGHHHHHHGEHPHSKQNSGASTPARKNSTGSECPCSKQEQCHKHSINITVGAVSYLFLFKLFFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="154" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IA64</accession>
    <name>Q8IA64_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC-type antigen peptide transporter</fullName>
            <ecNumber evidence="7">7.4.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">haf-9</name>
        <name evidence="11" type="ORF">CELE_ZK484.2</name>
        <name evidence="13" type="ORF">ZK484.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65972"/>
            <dbReference type="Rhea" id="RHEA-COMP:16941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:166823"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.4.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:65973"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.14" evidence="7"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD65799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_871810.1">
        <property type="nucleotide sequence ID" value="NM_182010.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IA64"/>
    <dbReference type="SMR" id="Q8IA64"/>
    <dbReference type="PeptideAtlas" id="Q8IA64"/>
    <dbReference type="GeneID" id="172288"/>
    <dbReference type="UCSC" id="ZK484.2b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001819"/>
    <dbReference type="CTD" id="172288"/>
    <dbReference type="WormBase" id="ZK484.2b">
        <property type="protein sequence ID" value="CE33261"/>
        <property type="gene ID" value="WBGene00001819"/>
        <property type="gene designation" value="haf-9"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001819">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IA64">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015433">
        <property type="term" value="F:ABC-type peptide antigen transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd18572">
        <property type="entry name" value="ABC_6TM_TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000271">
        <property type="entry name" value="HAlF transporter (PGP related)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002694">
        <property type="entry name" value="HAlF transporter (PGP related)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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        <property type="entry name" value="ABC_Tap-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00958">
        <property type="entry name" value="3a01208"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01896">
        <property type="entry name" value="TAP1PROTEIN"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="348"/>
            <end position="368"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="208"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD65799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="ZK484.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q8IA64"/>
        </source>
    </evidence>
    <sequence length="674" mass="75495" checksum="53762E3FAF526FF2" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IA74</accession>
    <name>Q8IA74_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">GST N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">gsto-3</name>
        <name evidence="3" type="ORF">CELE_K10F12.4</name>
        <name evidence="5" type="ORF">K10F12.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD72881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380016.1">
        <property type="nucleotide sequence ID" value="NM_001393255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IA74"/>
    <dbReference type="GeneID" id="175196"/>
    <dbReference type="KEGG" id="cel:CELE_K10F12.4"/>
    <dbReference type="UCSC" id="K10F12.4b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019636"/>
    <dbReference type="CTD" id="175196"/>
    <dbReference type="WormBase" id="K10F12.4b">
        <property type="protein sequence ID" value="CE31038"/>
        <property type="gene ID" value="WBGene00019636"/>
        <property type="gene designation" value="gsto-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164245_0_0_1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019636">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IA74">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000724">
        <property type="entry name" value="Glutathione S-Transferase, Omega class"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD72881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K10F12.4b"/>
        </source>
    </evidence>
    <sequence length="123" mass="13372" checksum="89328DD912813529" modified="2003-03-01" version="1">MVLPGNCSTSAALCMQFLTQLASVAIDQAYQPPQQPAYNPHEKLFVSYRSVPPPGSSPSSAAVPIRFSSYSSVGSNIRGLNSPTLHPGSIEPPLTPGNYRLYSMRFCPYAQRVLIYLAKKNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q8TA50</accession>
    <name>Q8TA50_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">lgc-27</name>
        <name evidence="4" type="ORF">CELE_Y74E4A.1</name>
        <name evidence="6" type="ORF">Y74E4A.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD70545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_740978.1">
        <property type="nucleotide sequence ID" value="NM_171848.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8TA50"/>
    <dbReference type="SMR" id="Q8TA50"/>
    <dbReference type="GeneID" id="173802"/>
    <dbReference type="UCSC" id="Y74E4A.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022283"/>
    <dbReference type="CTD" id="173802"/>
    <dbReference type="WormBase" id="Y74E4A.1a">
        <property type="protein sequence ID" value="CE30327"/>
        <property type="gene ID" value="WBGene00022283"/>
        <property type="gene designation" value="lgc-27"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053205_0_0_1"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022283">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8TA50">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000094">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000056">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004315130" evidence="2">
        <location>
            <begin position="20"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="3">
        <location>
            <begin position="94"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD70545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y74E4A.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q8TA50"/>
        </source>
    </evidence>
    <sequence length="425" mass="48846" checksum="D29E0275712DAF3D" modified="2002-06-01" version="1">MVEARWISLLLSLVTLSVAAYDIDCKWKSNITDIEDVAHHKYQVLEECLFYKLTSDADRMQDKSNALMMLPPTVAAGETLEVQVLDGSITEMWMNEVFKEMNINGFLKLSWKDRRLRWNPEEWKTEVLRLKSMGRLWSPDINSDKLQTGSQSTDFVNYHDIQSNYNGNVTARLEFRMKAQCQIDYTEYPNDRKHCCFNLQSNLYKRYVRFIMEHEGAHEMLNTKNTKTNWHIDPMYTWISKMNQENDNRAERLEVCVGVVRKSSTLAVELTLPVLISALILLLAPFFGKFNQQIYVKMFALLLQFLSFQFLAEKTPQLGFGDNIPKIYVFYAFTIGMTVLSLIATVMISAMSRVKRKVPPAHRYTLLASLLNANLCCGSEEEPTTDGTSSKDATSDWLQVHSALNNLSSILLIFIYIIGAIVIAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-04-22" modified="2026-01-28" version="163" xmlns="https://uniprot.org/uniprot">
    <accession>Q94252-2</accession>
    <name>LIPL4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Lipase lipl-4</fullName>
            <ecNumber evidence="4 5">3.1.1.-</ecNumber>
            <ecNumber evidence="3 5">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lipase-like 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lipl-4</name>
        <name evidence="7" type="ORF">K04A8.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2011" name="Curr. Biol." volume="21" first="1507" last="1514">
            <title>Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans.</title>
            <authorList>
                <person name="Lapierre L.R."/>
                <person name="Gelino S."/>
                <person name="Melendez A."/>
                <person name="Hansen M."/>
            </authorList>
            <dbReference type="PubMed" id="21906946"/>
            <dbReference type="DOI" id="10.1016/j.cub.2011.07.042"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="429" last="440">
            <title>omega-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.</title>
            <authorList>
                <person name="O'Rourke E.J."/>
                <person name="Kuballa P."/>
                <person name="Xavier R."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="23392608"/>
            <dbReference type="DOI" id="10.1101/gad.205294.112"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2013" name="Nat. Cell Biol." volume="15" first="668" last="676">
            <title>MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.</title>
            <authorList>
                <person name="O'Rourke E.J."/>
                <person name="Ruvkun G."/>
            </authorList>
            <dbReference type="PubMed" id="23604316"/>
            <dbReference type="DOI" id="10.1038/ncb2741"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2015" name="Science" volume="347" first="83" last="86">
            <title>Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Folick A."/>
                <person name="Oakley H.D."/>
                <person name="Yu Y."/>
                <person name="Armstrong E.H."/>
                <person name="Kumari M."/>
                <person name="Sanor L."/>
                <person name="Moore D.D."/>
                <person name="Ortlund E.A."/>
                <person name="Zechner R."/>
                <person name="Wang M.C."/>
            </authorList>
            <dbReference type="PubMed" id="25554789"/>
            <dbReference type="DOI" id="10.1126/science.1258857"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2017" name="Front. Mol. Neurosci." volume="10" first="101" last="101">
            <title>Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases.</title>
            <authorList>
                <person name="Shemesh N."/>
                <person name="Shai N."/>
                <person name="Meshnik L."/>
                <person name="Katalan R."/>
                <person name="Ben-Zvi A."/>
            </authorList>
            <dbReference type="PubMed" id="28503130"/>
            <dbReference type="DOI" id="10.3389/fnmol.2017.00101"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="2" key="7">
        <citation type="journal article" date="2019" name="Dev. Cell" volume="48" first="685" last="696">
            <title>Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity.</title>
            <authorList>
                <person name="Ramachandran P.V."/>
                <person name="Savini M."/>
                <person name="Folick A.K."/>
                <person name="Hu K."/>
                <person name="Masand R."/>
                <person name="Graham B.H."/>
                <person name="Wang M.C."/>
            </authorList>
            <dbReference type="PubMed" id="30713071"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2018.12.022"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94252-2</id>
            <name evidence="8">b</name>
            <sequence type="described" ref="VSP_060544"/>
        </isoform>
        <isoform>
            <id>Q94252-1</id>
            <name evidence="7">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4 5"/>
    <dbReference type="EC" id="3.1.1.3" evidence="3 5"/>
    <dbReference type="RefSeq" id="NP_001300136.1">
        <property type="nucleotide sequence ID" value="NM_001313207.3"/>
    </dbReference>
    <dbReference type="WormBase" id="K04A8.5b">
        <property type="protein sequence ID" value="CE50646"/>
        <property type="gene ID" value="WBGene00019376"/>
        <property type="gene designation" value="lipl-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="21906946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="23392608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="25554789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K04A8.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="K04A8.5b"/>
        </source>
    </evidence>
    <sequence length="254" mass="28699" checksum="8C2840C2039671BD" modified="1997-02-01" version="1" precursor="true">MIGKALEISGQESLYYTGFSLGTLTMFAKLSTDPKFSRKIKKYFALAPIGSIKHAHGVFLFLGRHFGKDYEEYVKKHGSDELFGSSLLFKKIVKYTCGLFDTLEEFCSDITLLFIGTANENWNQTRIPVYLAHTPAGSSSNVMAHLDQMFSYGGVPTFDMGEEKNLKAYGQKLPPQYNFTGIADVPIYLFWSDDDWLSTKQDLEETLFAQLNSQVVQGSFRIENYNHLHFIWGTNAASQVYNVITGIILQDDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QU3</accession>
    <name>Q95QU3_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Zc3h12a-like Ribonuclease NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">eri-9</name>
        <name evidence="5" type="ORF">C26E6.7</name>
        <name evidence="3" type="ORF">CELE_C26E6.7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD65731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B88445">
        <property type="entry name" value="B88445"/>
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    <dbReference type="RefSeq" id="NP_001379722.1">
        <property type="nucleotide sequence ID" value="NM_001392083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q95QU3"/>
    <dbReference type="SMR" id="Q95QU3"/>
    <dbReference type="IntAct" id="Q95QU3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="175665"/>
    <dbReference type="UCSC" id="C26E6.7a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00016143"/>
    <dbReference type="CTD" id="175665"/>
    <dbReference type="WormBase" id="C26E6.7a">
        <property type="protein sequence ID" value="CE01165"/>
        <property type="gene ID" value="WBGene00016143"/>
        <property type="gene designation" value="eri-9"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875795at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016143">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q95QU3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028079">
        <property type="entry name" value="RNase_Zc3h12a_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14626">
        <property type="entry name" value="RNase_Zc3h12a_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zc3h12a-like Ribonuclease NYN" evidence="2">
        <location>
            <begin position="335"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD65731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C26E6.7a"/>
        </source>
    </evidence>
    <sequence length="633" mass="73230" checksum="CEFD0D7D9F5F8A91" modified="2003-03-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2025-10-08" version="160" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QV3</accession>
    <name>Q95QV3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein Rab-3</fullName>
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    <gene>
        <name evidence="11 13" type="primary">rab-3</name>
        <name evidence="13" type="ORF">C18A3.6</name>
        <name evidence="11" type="ORF">CELE_C18A3.6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD65020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021973.1">
        <property type="nucleotide sequence ID" value="NM_001026802.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q95QV3"/>
    <dbReference type="SMR" id="Q95QV3"/>
    <dbReference type="GeneID" id="173971"/>
    <dbReference type="KEGG" id="cel:CELE_C18A3.6"/>
    <dbReference type="UCSC" id="C18A3.6a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004267"/>
    <dbReference type="CTD" id="173971"/>
    <dbReference type="WormBase" id="C18A3.6a">
        <property type="protein sequence ID" value="CE23555"/>
        <property type="gene ID" value="WBGene00004267"/>
        <property type="gene designation" value="rab-3"/>
    </dbReference>
    <dbReference type="OMA" id="PSSQCNC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="PhylomeDB" id="Q95QV3"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004267">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q95QV3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007617">
        <property type="term" value="P:mating behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040012">
        <property type="term" value="P:regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043051">
        <property type="term" value="P:regulation of nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd01865">
        <property type="entry name" value="Rab3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000206">
        <property type="entry name" value="Ras-related protein Rab-3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037872">
        <property type="entry name" value="Rab3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD65020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C18A3.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q95QV3"/>
        </source>
    </evidence>
    <sequence length="233" mass="26260" checksum="56E3A6BF883C6588" modified="2001-12-01" version="1">MNNQQAAIASARSRMAAGGQPQGATPGQPDQNFDYMFKLLIIGNSSVGKTSFLFRYCDDSFTSAFVSTVGIDFKVKTVFRGDKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNSVQDWCTQIKTYSWENAQVVLVGNKCDMDSERVVSMDRGRQLADQLGLEFFETSAKENINVKAVFEKLVEIICDKMAESLDKDPQQQPKGQKLEANPTQKPAQQQCNC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="185" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XTR1-2</accession>
    <name>CDK4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform a of Cyclin-dependent kinase 4 homolog</fullName>
            <shortName evidence="2">CDK4/6</shortName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cell division protein kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cdk-4</name>
        <name evidence="7" type="ORF">F18H3.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="1999" name="Development" volume="126" first="4849" last="4860">
            <title>Regulation of postembryonic G(1) cell cycle progression in Caenorhabditis elegans by a cyclin D/CDK-like complex.</title>
            <authorList>
                <person name="Park M."/>
                <person name="Krause M.W."/>
            </authorList>
            <dbReference type="PubMed" id="10518501"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CYD-1</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2001" name="Development" volume="128" first="4349" last="4359">
            <title>lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans.</title>
            <authorList>
                <person name="Boxem M."/>
                <person name="van den Heuvel S."/>
            </authorList>
            <dbReference type="PubMed" id="11684669"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-149</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2005" name="Dev. Cell" volume="9" first="489" last="499">
            <title>Cyclin D regulation of a sexually dimorphic asymmetric cell division.</title>
            <authorList>
                <person name="Tilmann C."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="16198291"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2005.09.004"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="5906" last="5906">
            <title>Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells.</title>
            <authorList>
                <person name="The I."/>
                <person name="Ruijtenberg S."/>
                <person name="Bouchet B.P."/>
                <person name="Cristobal A."/>
                <person name="Prinsen M.B."/>
                <person name="van Mourik T."/>
                <person name="Koreth J."/>
                <person name="Xu H."/>
                <person name="Heck A.J."/>
                <person name="Akhmanova A."/>
                <person name="Cuppen E."/>
                <person name="Boxem M."/>
                <person name="Munoz J."/>
                <person name="van den Heuvel S."/>
            </authorList>
            <dbReference type="PubMed" id="25562820"/>
            <dbReference type="DOI" id="10.1038/ncomms6906"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ASP-191</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9XTR1-1</id>
            <name evidence="7">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9XTR1-2</id>
            <name evidence="6">a</name>
            <sequence type="described" ref="VSP_057762"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="RefSeq" id="NP_510256.1">
        <property type="nucleotide sequence ID" value="NM_077855.8"/>
    </dbReference>
    <dbReference type="WormBase" id="F18H3.5a">
        <property type="protein sequence ID" value="CE18608"/>
        <property type="gene ID" value="WBGene00000406"/>
        <property type="gene designation" value="cdk-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="25562820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="10518501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAD48898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F18H3.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F18H3.5b"/>
        </source>
    </evidence>
    <sequence length="342" mass="39408" checksum="C07B7953AA8B43B5" modified="2001-12-01" version="2">MCENLYGEEYKMEILRLQKMMNNMTCGQMAKPLTMKDFQIHQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSVLREITVMKHLARKAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFLRNIPRGVPEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYSNTTAFTTLVVTLWYRSPEVLLQSYYNSTVDMWALGCIVSEIYCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESVIARDSFPQYRPTNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALSHPFLKPAVATKSRVLKQINFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XWX5</accession>
    <name>Q9XWX5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y43F8B.3</name>
        <name evidence="4 6" type="ORF">Y43F8B.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA21511.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001123046.2">
        <property type="nucleotide sequence ID" value="NM_001129574.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XWX5"/>
    <dbReference type="SMR" id="Q9XWX5"/>
    <dbReference type="MEROPS" id="I02.955"/>
    <dbReference type="GeneID" id="180277"/>
    <dbReference type="KEGG" id="cel:CELE_Y43F8B.3"/>
    <dbReference type="UCSC" id="Y43F8B.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012814"/>
    <dbReference type="CTD" id="180277"/>
    <dbReference type="WormBase" id="Y43F8B.3a">
        <property type="protein sequence ID" value="CE46772"/>
        <property type="gene ID" value="WBGene00012814"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008651_0_0_1"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012814">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XWX5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF1">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004336810" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="131"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="232"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="336"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="440"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="546"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="651"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="754"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="856"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="962"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA21511.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y43F8B.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XWX5"/>
        </source>
    </evidence>
    <sequence length="1178" mass="128480" checksum="AD261EA31604D374" modified="2012-01-25" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XWX6</accession>
    <name>Q9XWX6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GSKIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y43F8B.2</name>
        <name evidence="4 6" type="ORF">Y43F8B.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSKIP family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA21510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T26858">
        <property type="entry name" value="T26858"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XWX6"/>
    <dbReference type="SMR" id="Q9XWX6"/>
    <dbReference type="PeptideAtlas" id="Q9XWX6"/>
    <dbReference type="UCSC" id="Y43F8B.2b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012813"/>
    <dbReference type="WormBase" id="Y43F8B.2b">
        <property type="protein sequence ID" value="CE21887"/>
        <property type="gene ID" value="WBGene00012813"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012813">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XWX6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000004">
        <property type="entry name" value="Protein CBG05668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037395">
        <property type="entry name" value="GSKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490:SF5">
        <property type="entry name" value="GSKIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="3">
        <location>
            <begin position="84"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA21510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y43F8B.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XWX6"/>
        </source>
    </evidence>
    <sequence length="244" mass="26491" checksum="00B3FEF428151FDE" modified="1999-11-01" version="1">MTSLPPRNRSASLFEGSPFAPSSTTSPPTSSLAKMLKSEPIPCLRCGNVGSPTGSVPMSLHKVSSINRSAGTNPASRGGESSLELEAIAAVHELSFAVQSISVSEMLPRTPDLIFVNVTTLEAQPYCLELTLKGWRITSLRSDCMVGDFTRLELFTKYYDSLYLLMDDISPGYRERFSEKLVQRLKLIEAGEEDQVAPCASLQSPSLSTDSSSKESQYSSTESLPIVTPVSTPAIDPDFKPKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XWX8</accession>
    <name>Q9XWX8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y43F8B.1</name>
        <name evidence="2 4" type="ORF">Y43F8B.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA21508.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T26856">
        <property type="entry name" value="T26856"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XWX8"/>
    <dbReference type="PeptideAtlas" id="Q9XWX8"/>
    <dbReference type="UCSC" id="Y43F8B.1a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012812"/>
    <dbReference type="WormBase" id="Y43F8B.1a">
        <property type="protein sequence ID" value="CE32015"/>
        <property type="gene ID" value="WBGene00012812"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077486_0_0_1"/>
    <dbReference type="OrthoDB" id="5875553at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012812">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XWX8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA21508.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y43F8B.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XWX8"/>
        </source>
    </evidence>
    <sequence length="309" mass="35403" checksum="B0E488C2D5C922F0" modified="2003-03-01" version="2">MSPIMARKPQIQAEQLAQKFVEKPEEQKDKQAVQKGQQLEGAKRWVADSELREQPVNSMQQVEHGPKAVILADDACWQTQRRVPAEIQLPQVGKISIPELSEKEIQRTIVAQPASYHKVQWNEFPEEPKYEIGAVPKTKTQDWVPVNNEQNELQRSIYKPARMSAVWPPPQDELVKDGHSPLVVKANEDTAWIQQDQNGVLKQAVWGKTSRINRVWPPPENESTLSDFGPQHMPVVQWPPPEAEAHEREQVEVLQKHIPTKKMERQWPPPPPQYQVVESSGEIETRYNPAEVDQQQQAVNSLRMGHIQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-07-05" modified="2026-01-28" version="172" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXD1-2</accession>
    <name>KVS4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Probable voltage-gated potassium channel subunit kvs-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">kvs-4</name>
        <name evidence="3" type="ORF">Y48A6B.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2016" name="FEBS Lett." volume="590" first="76" last="92">
            <title>A novel bipartite UNC-101/AP-1 mu1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Zhou X."/>
                <person name="Zeng J."/>
                <person name="Ouyang C."/>
                <person name="Luo Q."/>
                <person name="Yu M."/>
                <person name="Yang Z."/>
                <person name="Wang H."/>
                <person name="Shen K."/>
                <person name="Shi A."/>
            </authorList>
            <dbReference type="PubMed" id="26762178"/>
            <dbReference type="DOI" id="10.1002/1873-3468.12043"/>
        </citation>
        <scope>INTERACTION WITH UNC-101</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF 217-TRP--GLU-221; 217-TRP--ILE-219; ILE-219; 496-GLU--LEU-500 AND 497-GLN--MET-498</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9XXD1-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_059007 VSP_059008"/>
        </isoform>
        <isoform>
            <id>Q9XXD1-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="WormBase" id="Y48A6B.6b">
        <property type="protein sequence ID" value="CE32077"/>
        <property type="gene ID" value="WBGene00012967"/>
        <property type="gene designation" value="kvs-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y48A6B.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="Y48A6B.6b"/>
        </source>
    </evidence>
    <sequence length="512" mass="57965" checksum="FEA4D7F9F8548D79" modified="2004-09-13" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-05-11" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>U4PAZ9-2</accession>
    <name>PTRN1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoform a of Patronin (microtubule-binding protein) homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptrn-1</name>
        <name evidence="5" type="ORF">F35B3.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2014" name="Cell Rep." volume="9" first="874" last="883">
            <title>The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans.</title>
            <authorList>
                <person name="Chuang M."/>
                <person name="Goncharov A."/>
                <person name="Wang S."/>
                <person name="Oegema K."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="25437544"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2014.09.054"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2014" name="Elife" volume="3" first="E01498" last="E01498">
            <title>PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons.</title>
            <authorList>
                <person name="Richardson C.E."/>
                <person name="Spilker K.A."/>
                <person name="Cueva J.G."/>
                <person name="Perrino J."/>
                <person name="Goodman M.B."/>
                <person name="Shen K."/>
            </authorList>
            <dbReference type="PubMed" id="24569477"/>
            <dbReference type="DOI" id="10.7554/eLife.01498"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2014" name="Elife" volume="3" first="E01637" last="E01637">
            <title>The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites.</title>
            <authorList>
                <person name="Marcette J.D."/>
                <person name="Chen J.J."/>
                <person name="Nonet M.L."/>
            </authorList>
            <dbReference type="PubMed" id="24569480"/>
            <dbReference type="DOI" id="10.7554/eLife.01637"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2015" name="Elife" volume="4" first="E08649" last="E08649">
            <title>NOCA-1 Functions with gamma-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans.</title>
            <authorList>
                <person name="Wang S."/>
                <person name="Wu D."/>
                <person name="Quintin S."/>
                <person name="Green R.A."/>
                <person name="Cheerambathur D.K."/>
                <person name="Ochoa S.D."/>
                <person name="Desai A."/>
                <person name="Oegema K."/>
            </authorList>
            <dbReference type="PubMed" id="26371552"/>
            <dbReference type="DOI" id="10.7554/eLife.08649"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2016" name="Elife" volume="5" first="E15833" last="E15833">
            <title>DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair.</title>
            <authorList>
                <person name="Chuang M."/>
                <person name="Hsiao T.I."/>
                <person name="Tong A."/>
                <person name="Xu S."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="27661253"/>
            <dbReference type="DOI" id="10.7554/eLife.15833"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH DAPK-1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
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        <citation type="journal article" date="2014" name="Cell Rep." volume="9" first="874" last="883">
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            <authorList>
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                <person name="Goncharov A."/>
                <person name="Wang S."/>
                <person name="Oegema K."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
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            <dbReference type="DOI" id="10.1016/j.celrep.2014.09.054"/>
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        <citation type="journal article" date="2014" name="Elife" volume="3" first="E01498" last="E01498">
            <title>PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons.</title>
            <authorList>
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                <person name="Spilker K.A."/>
                <person name="Cueva J.G."/>
                <person name="Perrino J."/>
                <person name="Goodman M.B."/>
                <person name="Shen K."/>
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            <dbReference type="PubMed" id="24569477"/>
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        </citation>
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        <scope>TISSUE SPECIFICITY</scope>
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        <citation type="journal article" date="2014" name="Elife" volume="3" first="E01637" last="E01637">
            <title>The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites.</title>
            <authorList>
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                <person name="Chen J.J."/>
                <person name="Nonet M.L."/>
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        <scope>TISSUE SPECIFICITY</scope>
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    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2015" name="Elife" volume="4" first="E08649" last="E08649">
            <title>NOCA-1 Functions with gamma-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans.</title>
            <authorList>
                <person name="Wang S."/>
                <person name="Wu D."/>
                <person name="Quintin S."/>
                <person name="Green R.A."/>
                <person name="Cheerambathur D.K."/>
                <person name="Ochoa S.D."/>
                <person name="Desai A."/>
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        <scope>DEVELOPMENTAL STAGE</scope>
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    </reference>
    <reference key="6">
        <citation type="journal article" date="2016" name="Elife" volume="5" first="E15833" last="E15833">
            <title>DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair.</title>
            <authorList>
                <person name="Chuang M."/>
                <person name="Hsiao T.I."/>
                <person name="Tong A."/>
                <person name="Xu S."/>
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            <dbReference type="DOI" id="10.7554/eLife.15833"/>
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        <scope>SUBCELLULAR LOCATION</scope>
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        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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            <strain evidence="2 3">Bristol N2</strain>
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    <reference evidence="1" key="2">
        <citation type="journal article" date="2014" name="Cell Rep." volume="9" first="874" last="883">
            <title>The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans.</title>
            <authorList>
                <person name="Chuang M."/>
                <person name="Goncharov A."/>
                <person name="Wang S."/>
                <person name="Oegema K."/>
                <person name="Jin Y."/>
                <person name="Chisholm A.D."/>
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            <dbReference type="DOI" id="10.1016/j.celrep.2014.09.054"/>
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        <citation type="journal article" date="2014" name="Elife" volume="3" first="E01498" last="E01498">
            <title>PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons.</title>
            <authorList>
                <person name="Richardson C.E."/>
                <person name="Spilker K.A."/>
                <person name="Cueva J.G."/>
                <person name="Perrino J."/>
                <person name="Goodman M.B."/>
                <person name="Shen K."/>
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            <dbReference type="PubMed" id="24569477"/>
            <dbReference type="DOI" id="10.7554/eLife.01498"/>
        </citation>
        <scope>FUNCTION</scope>
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        <scope>TISSUE SPECIFICITY</scope>
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    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2014" name="Elife" volume="3" first="E01637" last="E01637">
            <title>The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites.</title>
            <authorList>
                <person name="Marcette J.D."/>
                <person name="Chen J.J."/>
                <person name="Nonet M.L."/>
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            <dbReference type="PubMed" id="24569480"/>
            <dbReference type="DOI" id="10.7554/eLife.01637"/>
        </citation>
        <scope>FUNCTION</scope>
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        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2015" name="Elife" volume="4" first="E08649" last="E08649">
            <title>NOCA-1 Functions with gamma-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans.</title>
            <authorList>
                <person name="Wang S."/>
                <person name="Wu D."/>
                <person name="Quintin S."/>
                <person name="Green R.A."/>
                <person name="Cheerambathur D.K."/>
                <person name="Ochoa S.D."/>
                <person name="Desai A."/>
                <person name="Oegema K."/>
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        <scope>DEVELOPMENTAL STAGE</scope>
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    <reference key="6">
        <citation type="journal article" date="2016" name="Elife" volume="5" first="E15833" last="E15833">
            <title>DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair.</title>
            <authorList>
                <person name="Chuang M."/>
                <person name="Hsiao T.I."/>
                <person name="Tong A."/>
                <person name="Xu S."/>
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            <strain evidence="16 17">Bristol N2</strain>
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</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
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        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
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    </dbReference>
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        <property type="entry name" value="PARP_ALPHA_HD"/>
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    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0013">ADP-ribosylation</keyword>
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    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="16">
        <location>
            <begin position="120"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CTQ86412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="Y71F9AL.18d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARD5"/>
        </source>
    </evidence>
    <sequence length="348" mass="39650" checksum="4A8C01AC540BA13C" modified="2015-11-11" version="1">MSIFDVENMKSALKSFEMDVNKMPLGRLSHNQINLAFEVLNDISDLLVKLPIDASRILDFSNKFYTIIPHNFGMRVPEPIDSFHKIKEKNNMLNALLDIKFAYDQISGGDVPASTSLGIDPVDINYQKLKCIMEPLQQGCDDWNMIHQYLKNTHGATHDLKVELIDILKLNRDNESSKFKRHIGNRRLLWHGSGKMNFAGILGQGLRIAPPEAPVSGYMFGKGVYFADMFSKSFFYCRANAKEEAYLLLCDVALGNVQQLMASKNVSRQTLPAGFQSVQGLGRQCPREIGSYNHPDGYTIPLGLTYMQLQGKQDVDYHLLYNEFIVYDVDQIQLKYLVRVKMHHARHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARE1</accession>
    <name>A0A0K3ARE1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">gld-2</name>
        <name evidence="17" type="ORF">CELE_ZC308.1</name>
        <name evidence="19" type="ORF">ZC308.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300478.1">
        <property type="nucleotide sequence ID" value="NM_001313549.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A0K3ARE1"/>
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        <property type="gene ID" value="WBGene00001596"/>
        <property type="gene designation" value="gld-2"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
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        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="12" id="KW-0464">Manganese</keyword>
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    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="16">
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            <begin position="190"/>
            <end position="328"/>
        </location>
    </feature>
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            <end position="456"/>
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    </feature>
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            <end position="154"/>
        </location>
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            <end position="495"/>
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            <begin position="607"/>
            <end position="754"/>
        </location>
    </feature>
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            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
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        <location>
            <begin position="636"/>
            <end position="676"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="685"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="710"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CTQ86417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="ZC308.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARE1"/>
        </source>
    </evidence>
    <sequence length="754" mass="84202" checksum="E1F55BB9718B0E1E" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARE2</accession>
    <name>A0A0K3ARE2_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y55B1BR.6</name>
        <name evidence="2 4" type="ORF">Y55B1BR.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299915.1">
        <property type="nucleotide sequence ID" value="NM_001312986.1"/>
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    <dbReference type="CTD" id="3565001"/>
    <dbReference type="WormBase" id="Y55B1BR.6f">
        <property type="protein sequence ID" value="CE50187"/>
        <property type="gene ID" value="WBGene00044401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5803449at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044401">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARE2">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y55B1BR.6f"/>
        </source>
    </evidence>
    <sequence length="130" mass="14583" checksum="2B7B95492E615466" modified="2015-11-11" version="1">MQRNQIHRNACEDAAAQFMEITANPPLKVTTKHRHSVHSGAVPHLQVRMTHRNSSSNGSSDRFELEPVEPTEGGPQRSTSSDYCKVDKKHSISGTTRLLKWLGISDKQSSESAQQINKKPISKRRMSTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARE8</accession>
    <name>A0A0K3ARE8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">daf-2</name>
        <name evidence="12" type="ORF">CELE_Y55D5A.5</name>
        <name evidence="14" type="ORF">Y55D5A.5</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299920.1">
        <property type="nucleotide sequence ID" value="NM_001312991.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARE8"/>
    <dbReference type="SMR" id="A0A0K3ARE8"/>
    <dbReference type="PeptideAtlas" id="A0A0K3ARE8"/>
    <dbReference type="GeneID" id="175410"/>
    <dbReference type="AGR" id="WB:WBGene00000898"/>
    <dbReference type="CTD" id="175410"/>
    <dbReference type="WormBase" id="Y55D5A.5g">
        <property type="protein sequence ID" value="CE50631"/>
        <property type="gene ID" value="WBGene00000898"/>
        <property type="gene designation" value="daf-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546826at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000898">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARE8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05032">
        <property type="entry name" value="PTKc_InsR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000987">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000940">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="72"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="595"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CTQ86620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="Y55D5A.5g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARE8"/>
        </source>
    </evidence>
    <sequence length="672" mass="75265" checksum="9AFC43C2D8A02D44" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-08-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AUE4-10</accession>
    <name>SEA2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isoform j of Signal element on autosome protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sea-2</name>
        <name evidence="9" type="ORF">K10G6.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>RNA-BINDING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 415-CYS--CYS-435; ALA-1398; 415-CYS--CYS-418; 1670-CYS--CYS-1690 AND 1670-CYS--CYS-1673</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="1159" last="1178">
            <title>Molecular antagonism between X-chromosome and autosome signals determines nematode sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Nix P."/>
                <person name="Jow M.M."/>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="23666922"/>
            <dbReference type="DOI" id="10.1101/gad.217026.113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A0K3AUE4-19</id>
            <name evidence="21">s</name>
            <sequence type="described" ref="VSP_060633"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-6</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060633 VSP_060640 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-12</id>
            <name evidence="14">l</name>
            <sequence type="described" ref="VSP_060637 VSP_060635 VSP_060638 VSP_060640"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_060640 VSP_060638 VSP_060636 VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060636"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-5</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060638 VSP_060640 VSP_060634"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-18</id>
            <name evidence="20">r</name>
            <sequence type="described" ref="VSP_060634"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_060638 VSP_060637 VSP_060640"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-16</id>
            <name evidence="18">p</name>
            <sequence type="described" ref="VSP_060632"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-7</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_060640 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-11</id>
            <name evidence="13">k</name>
            <sequence type="described" ref="VSP_060635 VSP_060640 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-13</id>
            <name evidence="15">m</name>
            <sequence type="described" ref="VSP_060634 VSP_060640 VSP_060637 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-4</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060636 VSP_060638 VSP_060640"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-17</id>
            <name evidence="19">q</name>
            <sequence type="described" ref="VSP_060637 VSP_060634"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-1</id>
            <name evidence="9">g</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060637 VSP_060636 VSP_060639"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-14</id>
            <name evidence="16">n</name>
            <sequence type="described" ref="VSP_060635"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-15</id>
            <name evidence="17">o</name>
            <sequence type="described" ref="VSP_060637 VSP_060635"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001368517.1">
        <property type="nucleotide sequence ID" value="NM_001381375.1"/>
    </dbReference>
    <dbReference type="WormBase" id="K10G6.3j">
        <property type="protein sequence ID" value="CE50480"/>
        <property type="gene ID" value="WBGene00004751"/>
        <property type="gene designation" value="sea-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="K10G6.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="K10G6.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="K10G6.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="K10G6.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K10G6.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="K10G6.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="K10G6.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="K10G6.3h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="K10G6.3i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="K10G6.3j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="K10G6.3k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="K10G6.3l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="K10G6.3m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="K10G6.3n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="K10G6.3o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="K10G6.3p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="K10G6.3q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
            <dbReference type="WormBase" id="K10G6.3r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
            <dbReference type="WormBase" id="K10G6.3s"/>
        </source>
    </evidence>
    <sequence length="1584" mass="172925" checksum="B6C6A6FFF2606F5E" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-08-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AUE4-11</accession>
    <name>SEA2_CAEEL</name>
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        <recommendedName>
            <fullName evidence="9">Isoform k of Signal element on autosome protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sea-2</name>
        <name evidence="9" type="ORF">K10G6.3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>RNA-BINDING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 415-CYS--CYS-435; ALA-1398; 415-CYS--CYS-418; 1670-CYS--CYS-1690 AND 1670-CYS--CYS-1673</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="1159" last="1178">
            <title>Molecular antagonism between X-chromosome and autosome signals determines nematode sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Nix P."/>
                <person name="Jow M.M."/>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="23666922"/>
            <dbReference type="DOI" id="10.1101/gad.217026.113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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        <event type="alternative splicing"/>
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            <id>A0A0K3AUE4-7</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_060638 VSP_060640"/>
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        <isoform>
            <id>A0A0K3AUE4-19</id>
            <name evidence="21">s</name>
            <sequence type="described" ref="VSP_060633"/>
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        <isoform>
            <id>A0A0K3AUE4-11</id>
            <name evidence="13">k</name>
            <sequence type="described" ref="VSP_060640 VSP_060638 VSP_060635"/>
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        <isoform>
            <id>A0A0K3AUE4-13</id>
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            <id>A0A0K3AUE4-15</id>
            <name evidence="17">o</name>
            <sequence type="described" ref="VSP_060635 VSP_060637"/>
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            <id>A0A0K3AUE4-1</id>
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        <isoform>
            <id>A0A0K3AUE4-8</id>
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            <sequence type="described" ref="VSP_060638 VSP_060640 VSP_060637"/>
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        <isoform>
            <id>A0A0K3AUE4-14</id>
            <name evidence="16">n</name>
            <sequence type="described" ref="VSP_060635"/>
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        <isoform>
            <id>A0A0K3AUE4-10</id>
            <name evidence="12">j</name>
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        <isoform>
            <id>A0A0K3AUE4-4</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060640 VSP_060638 VSP_060636"/>
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        <isoform>
            <id>A0A0K3AUE4-18</id>
            <name evidence="20">r</name>
            <sequence type="described" ref="VSP_060634"/>
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        <isoform>
            <id>A0A0K3AUE4-3</id>
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            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060636"/>
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            <id>A0A0K3AUE4-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-17</id>
            <name evidence="19">q</name>
            <sequence type="described" ref="VSP_060637 VSP_060634"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-12</id>
            <name evidence="14">l</name>
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        <isoform>
            <id>A0A0K3AUE4-6</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060640 VSP_060638 VSP_060633"/>
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        <isoform>
            <id>A0A0K3AUE4-16</id>
            <name evidence="18">p</name>
            <sequence type="described" ref="VSP_060632"/>
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    <dbReference type="RefSeq" id="NP_001368518.1">
        <property type="nucleotide sequence ID" value="NM_001381376.1"/>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000312" key="8">
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        <source>
            <dbReference type="WormBase" id="K10G6.3g"/>
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    </evidence>
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            <dbReference type="WormBase" id="K10G6.3i"/>
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    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="K10G6.3j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="K10G6.3k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="K10G6.3l"/>
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    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="K10G6.3m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="K10G6.3n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="K10G6.3o"/>
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    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="K10G6.3p"/>
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    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="K10G6.3q"/>
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        <source>
            <dbReference type="WormBase" id="K10G6.3r"/>
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    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
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    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2020-08-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AUE4-12</accession>
    <name>SEA2_CAEEL</name>
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        <recommendedName>
            <fullName evidence="9">Isoform l of Signal element on autosome protein 2</fullName>
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        <name evidence="9" type="primary">sea-2</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>RNA-BINDING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 415-CYS--CYS-435; ALA-1398; 415-CYS--CYS-418; 1670-CYS--CYS-1690 AND 1670-CYS--CYS-1673</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="1159" last="1178">
            <title>Molecular antagonism between X-chromosome and autosome signals determines nematode sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Nix P."/>
                <person name="Jow M.M."/>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="23666922"/>
            <dbReference type="DOI" id="10.1101/gad.217026.113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
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            <id>A0A0K3AUE4-2</id>
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            <sequence type="described" ref="VSP_060636"/>
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            <id>A0A0K3AUE4-18</id>
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            <sequence type="described" ref="VSP_060640 VSP_060638"/>
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        <isoform>
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            <id>A0A0K3AUE4-4</id>
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    <evidence type="ECO:0000312" key="21">
        <source>
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        </source>
    </evidence>
    <sequence length="1504" mass="164197" checksum="E850C8A38FE01810" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-08-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AUE4-13</accession>
    <name>SEA2_CAEEL</name>
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        <recommendedName>
            <fullName evidence="9">Isoform m of Signal element on autosome protein 2</fullName>
        </recommendedName>
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        <name evidence="9" type="primary">sea-2</name>
        <name evidence="9" type="ORF">K10G6.3</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>RNA-BINDING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 415-CYS--CYS-435; ALA-1398; 415-CYS--CYS-418; 1670-CYS--CYS-1690 AND 1670-CYS--CYS-1673</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="1159" last="1178">
            <title>Molecular antagonism between X-chromosome and autosome signals determines nematode sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Nix P."/>
                <person name="Jow M.M."/>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="23666922"/>
            <dbReference type="DOI" id="10.1101/gad.217026.113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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            <id>A0A0K3AUE4-10</id>
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            <sequence type="described" ref="VSP_060636 VSP_060637 VSP_060638 VSP_060640"/>
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        <isoform>
            <id>A0A0K3AUE4-16</id>
            <name evidence="18">p</name>
            <sequence type="described" ref="VSP_060632"/>
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        <isoform>
            <id>A0A0K3AUE4-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060637 VSP_060636 VSP_060639"/>
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            <id>A0A0K3AUE4-8</id>
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            <id>A0A0K3AUE4-18</id>
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            <sequence type="described" ref="VSP_060634"/>
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            <id>A0A0K3AUE4-11</id>
            <name evidence="13">k</name>
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            <id>A0A0K3AUE4-1</id>
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            <id>A0A0K3AUE4-2</id>
            <name evidence="3">a</name>
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            <id>A0A0K3AUE4-19</id>
            <name evidence="21">s</name>
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            <id>A0A0K3AUE4-14</id>
            <name evidence="16">n</name>
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            <id>A0A0K3AUE4-7</id>
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        <isoform>
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        <isoform>
            <id>A0A0K3AUE4-4</id>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000312" key="17">
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    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
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    </evidence>
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<entry dataset="Swiss-Prot" created="2020-08-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AUE4-14</accession>
    <name>SEA2_CAEEL</name>
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        <recommendedName>
            <fullName evidence="9">Isoform n of Signal element on autosome protein 2</fullName>
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        <name evidence="9" type="primary">sea-2</name>
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    <reference evidence="2" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>RNA-BINDING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 415-CYS--CYS-435; ALA-1398; 415-CYS--CYS-418; 1670-CYS--CYS-1690 AND 1670-CYS--CYS-1673</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="1159" last="1178">
            <title>Molecular antagonism between X-chromosome and autosome signals determines nematode sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Nix P."/>
                <person name="Jow M.M."/>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="23666922"/>
            <dbReference type="DOI" id="10.1101/gad.217026.113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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</entry>
<entry dataset="Swiss-Prot" created="2020-08-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AUE4-15</accession>
    <name>SEA2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isoform o of Signal element on autosome protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sea-2</name>
        <name evidence="9" type="ORF">K10G6.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>RNA-BINDING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 415-CYS--CYS-435; ALA-1398; 415-CYS--CYS-418; 1670-CYS--CYS-1690 AND 1670-CYS--CYS-1673</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="1159" last="1178">
            <title>Molecular antagonism between X-chromosome and autosome signals determines nematode sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Nix P."/>
                <person name="Jow M.M."/>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="23666922"/>
            <dbReference type="DOI" id="10.1101/gad.217026.113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A0K3AUE4-11</id>
            <name evidence="13">k</name>
            <sequence type="described" ref="VSP_060635 VSP_060638 VSP_060640"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-19</id>
            <name evidence="21">s</name>
            <sequence type="described" ref="VSP_060633"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060636 VSP_060637 VSP_060639"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-12</id>
            <name evidence="14">l</name>
            <sequence type="described" ref="VSP_060635 VSP_060640 VSP_060637 VSP_060638"/>
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        <isoform>
            <id>A0A0K3AUE4-1</id>
            <name evidence="9">g</name>
            <sequence type="displayed"/>
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        <isoform>
            <id>A0A0K3AUE4-6</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060640 VSP_060638 VSP_060633"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-4</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060636 VSP_060640 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060636"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-7</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_060640 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-14</id>
            <name evidence="16">n</name>
            <sequence type="described" ref="VSP_060635"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-17</id>
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            <sequence type="described" ref="VSP_060637 VSP_060634"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-15</id>
            <name evidence="17">o</name>
            <sequence type="described" ref="VSP_060637 VSP_060635"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-13</id>
            <name evidence="15">m</name>
            <sequence type="described" ref="VSP_060638 VSP_060634 VSP_060640 VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_060637 VSP_060638 VSP_060640"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-16</id>
            <name evidence="18">p</name>
            <sequence type="described" ref="VSP_060632"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-5</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060638 VSP_060634 VSP_060640"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_060638 VSP_060637 VSP_060640 VSP_060636"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-18</id>
            <name evidence="20">r</name>
            <sequence type="described" ref="VSP_060634"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001300569.1">
        <property type="nucleotide sequence ID" value="NM_001313640.3"/>
    </dbReference>
    <dbReference type="WormBase" id="K10G6.3o">
        <property type="protein sequence ID" value="CE50457"/>
        <property type="gene ID" value="WBGene00004751"/>
        <property type="gene designation" value="sea-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
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    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="K10G6.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="K10G6.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="K10G6.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="K10G6.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K10G6.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="K10G6.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="K10G6.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="K10G6.3h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="K10G6.3i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="K10G6.3j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="K10G6.3k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="K10G6.3l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="K10G6.3m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="K10G6.3n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="K10G6.3o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="K10G6.3p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="K10G6.3q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
            <dbReference type="WormBase" id="K10G6.3r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
            <dbReference type="WormBase" id="K10G6.3s"/>
        </source>
    </evidence>
    <sequence length="1647" mass="180791" checksum="BF11EE46443D946E" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-08-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AUE4-16</accession>
    <name>SEA2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isoform p of Signal element on autosome protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sea-2</name>
        <name evidence="9" type="ORF">K10G6.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>RNA-BINDING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 415-CYS--CYS-435; ALA-1398; 415-CYS--CYS-418; 1670-CYS--CYS-1690 AND 1670-CYS--CYS-1673</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="1159" last="1178">
            <title>Molecular antagonism between X-chromosome and autosome signals determines nematode sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Nix P."/>
                <person name="Jow M.M."/>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="23666922"/>
            <dbReference type="DOI" id="10.1101/gad.217026.113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A0K3AUE4-6</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060633 VSP_060640 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-13</id>
            <name evidence="15">m</name>
            <sequence type="described" ref="VSP_060640 VSP_060637 VSP_060634 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-1</id>
            <name evidence="9">g</name>
            <sequence type="displayed"/>
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        <isoform>
            <id>A0A0K3AUE4-7</id>
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            <sequence type="described" ref="VSP_060640 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-15</id>
            <name evidence="17">o</name>
            <sequence type="described" ref="VSP_060635 VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-4</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060638 VSP_060640 VSP_060636"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-19</id>
            <name evidence="21">s</name>
            <sequence type="described" ref="VSP_060633"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-17</id>
            <name evidence="19">q</name>
            <sequence type="described" ref="VSP_060637 VSP_060634"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060636"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-18</id>
            <name evidence="20">r</name>
            <sequence type="described" ref="VSP_060634"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-3</id>
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        <isoform>
            <id>A0A0K3AUE4-11</id>
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        </isoform>
        <isoform>
            <id>A0A0K3AUE4-8</id>
            <name evidence="10">h</name>
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        </isoform>
        <isoform>
            <id>A0A0K3AUE4-10</id>
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        </isoform>
        <isoform>
            <id>A0A0K3AUE4-12</id>
            <name evidence="14">l</name>
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        <isoform>
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            <sequence type="described" ref="VSP_060635"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-5</id>
            <name evidence="6">d</name>
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        </isoform>
        <isoform>
            <id>A0A0K3AUE4-16</id>
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        <property type="gene ID" value="WBGene00004751"/>
        <property type="gene designation" value="sea-2"/>
    </dbReference>
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    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2020-08-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AUE4-17</accession>
    <name>SEA2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isoform q of Signal element on autosome protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sea-2</name>
        <name evidence="9" type="ORF">K10G6.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>RNA-BINDING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 415-CYS--CYS-435; ALA-1398; 415-CYS--CYS-418; 1670-CYS--CYS-1690 AND 1670-CYS--CYS-1673</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="1159" last="1178">
            <title>Molecular antagonism between X-chromosome and autosome signals determines nematode sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Nix P."/>
                <person name="Jow M.M."/>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="23666922"/>
            <dbReference type="DOI" id="10.1101/gad.217026.113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A0K3AUE4-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_060636"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-7</id>
            <name evidence="8">f</name>
            <sequence type="described" ref="VSP_060640 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-13</id>
            <name evidence="15">m</name>
            <sequence type="described" ref="VSP_060640 VSP_060638 VSP_060634 VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-1</id>
            <name evidence="9">g</name>
            <sequence type="displayed"/>
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        <isoform>
            <id>A0A0K3AUE4-11</id>
            <name evidence="13">k</name>
            <sequence type="described" ref="VSP_060640 VSP_060635 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-15</id>
            <name evidence="17">o</name>
            <sequence type="described" ref="VSP_060635 VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-12</id>
            <name evidence="14">l</name>
            <sequence type="described" ref="VSP_060640 VSP_060635 VSP_060637 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_060636 VSP_060637 VSP_060638 VSP_060640"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-16</id>
            <name evidence="18">p</name>
            <sequence type="described" ref="VSP_060632"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-3</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_060636 VSP_060639 VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-5</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060638 VSP_060634 VSP_060640"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-4</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060638 VSP_060636 VSP_060640"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-6</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060633 VSP_060638 VSP_060640"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-18</id>
            <name evidence="20">r</name>
            <sequence type="described" ref="VSP_060634"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-17</id>
            <name evidence="19">q</name>
            <sequence type="described" ref="VSP_060637 VSP_060634"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-14</id>
            <name evidence="16">n</name>
            <sequence type="described" ref="VSP_060635"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-19</id>
            <name evidence="21">s</name>
            <sequence type="described" ref="VSP_060633"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-9</id>
            <name evidence="11">i</name>
            <sequence type="described" ref="VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_060638 VSP_060640 VSP_060637"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001300571.1">
        <property type="nucleotide sequence ID" value="NM_001313642.3"/>
    </dbReference>
    <dbReference type="WormBase" id="K10G6.3q">
        <property type="protein sequence ID" value="CE50395"/>
        <property type="gene ID" value="WBGene00004751"/>
        <property type="gene designation" value="sea-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="K10G6.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="K10G6.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="K10G6.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="K10G6.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="K10G6.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="WormBase" id="K10G6.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="WormBase" id="K10G6.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="WormBase" id="K10G6.3h"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="WormBase" id="K10G6.3i"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="K10G6.3j"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="WormBase" id="K10G6.3k"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="14">
        <source>
            <dbReference type="WormBase" id="K10G6.3l"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="15">
        <source>
            <dbReference type="WormBase" id="K10G6.3m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
            <dbReference type="WormBase" id="K10G6.3n"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="17">
        <source>
            <dbReference type="WormBase" id="K10G6.3o"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="18">
        <source>
            <dbReference type="WormBase" id="K10G6.3p"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="19">
        <source>
            <dbReference type="WormBase" id="K10G6.3q"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
            <dbReference type="WormBase" id="K10G6.3r"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
            <dbReference type="WormBase" id="K10G6.3s"/>
        </source>
    </evidence>
    <sequence length="1485" mass="163642" checksum="9BFD4E66423934D3" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-08-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AUE4-18</accession>
    <name>SEA2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isoform r of Signal element on autosome protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sea-2</name>
        <name evidence="9" type="ORF">K10G6.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>RNA-BINDING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 415-CYS--CYS-435; ALA-1398; 415-CYS--CYS-418; 1670-CYS--CYS-1690 AND 1670-CYS--CYS-1673</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="1159" last="1178">
            <title>Molecular antagonism between X-chromosome and autosome signals determines nematode sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Nix P."/>
                <person name="Jow M.M."/>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="23666922"/>
            <dbReference type="DOI" id="10.1101/gad.217026.113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A0A0K3AUE4-5</id>
            <name evidence="6">d</name>
            <sequence type="described" ref="VSP_060640 VSP_060638 VSP_060634"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-17</id>
            <name evidence="19">q</name>
            <sequence type="described" ref="VSP_060637 VSP_060634"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-14</id>
            <name evidence="16">n</name>
            <sequence type="described" ref="VSP_060635"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-1</id>
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            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-8</id>
            <name evidence="10">h</name>
            <sequence type="described" ref="VSP_060638 VSP_060640 VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-13</id>
            <name evidence="15">m</name>
            <sequence type="described" ref="VSP_060640 VSP_060634 VSP_060638 VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-4</id>
            <name evidence="5">c</name>
            <sequence type="described" ref="VSP_060636 VSP_060638 VSP_060640"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-10</id>
            <name evidence="12">j</name>
            <sequence type="described" ref="VSP_060638 VSP_060640 VSP_060637 VSP_060636"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-11</id>
            <name evidence="13">k</name>
            <sequence type="described" ref="VSP_060640 VSP_060638 VSP_060635"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-6</id>
            <name evidence="7">e</name>
            <sequence type="described" ref="VSP_060638 VSP_060640 VSP_060633"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-3</id>
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        <isoform>
            <id>A0A0K3AUE4-9</id>
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            <sequence type="described" ref="VSP_060637"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-12</id>
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        <isoform>
            <id>A0A0K3AUE4-2</id>
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        </isoform>
        <isoform>
            <id>A0A0K3AUE4-7</id>
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            <sequence type="described" ref="VSP_060640 VSP_060638"/>
        </isoform>
        <isoform>
            <id>A0A0K3AUE4-15</id>
            <name evidence="17">o</name>
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        </isoform>
        <isoform>
            <id>A0A0K3AUE4-19</id>
            <name evidence="21">s</name>
            <sequence type="described" ref="VSP_060633"/>
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        <isoform>
            <id>A0A0K3AUE4-16</id>
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        <isoform>
            <id>A0A0K3AUE4-18</id>
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            <sequence type="described" ref="VSP_060634"/>
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    </comment>
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        <property type="gene designation" value="sea-2"/>
    </dbReference>
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        <property type="component" value="Chromosome II"/>
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    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="K10G6.3a"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000312" key="14">
        <source>
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    </evidence>
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        <source>
            <dbReference type="WormBase" id="K10G6.3m"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="16">
        <source>
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        <source>
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    <evidence type="ECO:0000312" key="18">
        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000312" key="20">
        <source>
            <dbReference type="WormBase" id="K10G6.3r"/>
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    </evidence>
    <evidence type="ECO:0000312" key="21">
        <source>
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    </evidence>
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</entry>
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    <accession>A0A0K3AUE4-19</accession>
    <name>SEA2_CAEEL</name>
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        <recommendedName>
            <fullName evidence="9">Isoform s of Signal element on autosome protein 2</fullName>
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        <name evidence="9" type="primary">sea-2</name>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="Development" volume="138" first="2059" last="2068">
            <title>The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.</title>
            <authorList>
                <person name="Huang X."/>
                <person name="Zhang H."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="21471153"/>
            <dbReference type="DOI" id="10.1242/dev.057109"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>RNA-BINDING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF 415-CYS--CYS-435; ALA-1398; 415-CYS--CYS-418; 1670-CYS--CYS-1690 AND 1670-CYS--CYS-1673</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2013" name="Genes Dev." volume="27" first="1159" last="1178">
            <title>Molecular antagonism between X-chromosome and autosome signals determines nematode sex.</title>
            <authorList>
                <person name="Farboud B."/>
                <person name="Nix P."/>
                <person name="Jow M.M."/>
                <person name="Gladden J.M."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="23666922"/>
            <dbReference type="DOI" id="10.1101/gad.217026.113"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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        <isoform>
            <id>A0A0K3AUE4-14</id>
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            <id>A0A0K3AUE4-5</id>
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            <id>A0A0K3AUE4-17</id>
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    </evidence>
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    <organism>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2004" name="J. Mol. Biol." volume="338" first="745" last="755">
            <title>A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Isermann K."/>
                <person name="Liebau E."/>
                <person name="Roeder T."/>
                <person name="Bruchhaus I."/>
            </authorList>
            <dbReference type="PubMed" id="15099742"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2004.03.021"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="19839" last="19844">
            <title>A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.</title>
            <authorList>
                <person name="Olahova M."/>
                <person name="Taylor S.R."/>
                <person name="Khazaipoul S."/>
                <person name="Wang J."/>
                <person name="Morgan B.A."/>
                <person name="Matsumoto K."/>
                <person name="Blackwell T.K."/>
                <person name="Veal E.A."/>
            </authorList>
            <dbReference type="PubMed" id="19064914"/>
            <dbReference type="DOI" id="10.1073/pnas.0805507105"/>
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        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2011" name="Antioxid. Redox Signal." volume="14" first="725" last="730">
            <title>Is overoxidation of peroxiredoxin physiologically significant?</title>
            <authorList>
                <person name="Thamsen M."/>
                <person name="Kumsta C."/>
                <person name="Li F."/>
                <person name="Jakob U."/>
            </authorList>
            <dbReference type="PubMed" id="20964547"/>
            <dbReference type="DOI" id="10.1089/ars.2010.3717"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2011" name="Antioxid. Redox Signal." volume="14" first="1023" last="1037">
            <title>Effects of oxidative stress on behavior, physiology, and the redox thiol proteome of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kumsta C."/>
                <person name="Thamsen M."/>
                <person name="Jakob U."/>
            </authorList>
            <dbReference type="PubMed" id="20649472"/>
            <dbReference type="DOI" id="10.1089/ars.2010.3203"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="4" key="6">
        <citation type="journal article" date="2014" name="BMC Biol." volume="12" first="64" last="64">
            <title>Genome-wide screening identifies new genes required for stress-induced phase 2 detoxification gene expression in animals.</title>
            <authorList>
                <person name="Crook-McMahon H.M."/>
                <person name="Olahova M."/>
                <person name="Button E.L."/>
                <person name="Winter J.J."/>
                <person name="Veal E.A."/>
            </authorList>
            <dbReference type="PubMed" id="25204677"/>
            <dbReference type="DOI" id="10.1186/s12915-014-0064-6"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="4" key="7">
        <citation type="journal article" date="2014" name="Proc. Natl. Acad. Sci. U.S.A." volume="111" first="E2501" last="E2509">
            <title>Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.</title>
            <authorList>
                <person name="De Haes W."/>
                <person name="Frooninckx L."/>
                <person name="Van Assche R."/>
                <person name="Smolders A."/>
                <person name="Depuydt G."/>
                <person name="Billen J."/>
                <person name="Braeckman B.P."/>
                <person name="Schoofs L."/>
                <person name="Temmerman L."/>
            </authorList>
            <dbReference type="PubMed" id="24889636"/>
            <dbReference type="DOI" id="10.1073/pnas.1321776111"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="4" key="8">
        <citation type="journal article" date="2015" name="Aging Cell" volume="14" first="558" last="568">
            <title>A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity.</title>
            <authorList>
                <person name="Olahova M."/>
                <person name="Veal E.A."/>
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            <dbReference type="DOI" id="10.1111/acel.12321"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference evidence="4" key="9">
        <citation type="journal article" date="2015" name="Neuron" volume="85" first="804" last="818">
            <title>Light and hydrogen peroxide inhibit C. elegans Feeding through gustatory receptor orthologs and pharyngeal neurons.</title>
            <authorList>
                <person name="Bhatla N."/>
                <person name="Horvitz H.R."/>
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            <dbReference type="DOI" id="10.1016/j.neuron.2014.12.061"/>
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        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
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    <reference evidence="4" key="10">
        <citation type="journal article" date="2018" name="Redox Biol." volume="14" first="386" last="390">
            <title>Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin?</title>
            <authorList>
                <person name="Henderson D."/>
                <person name="Huebner C."/>
                <person name="Markowitz M."/>
                <person name="Taube N."/>
                <person name="Harvanek Z.M."/>
                <person name="Jakob U."/>
                <person name="Knoefler D."/>
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            <dbReference type="DOI" id="10.1016/j.redox.2017.10.003"/>
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        <scope>DEVELOPMENTAL STAGE</scope>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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        <citation type="journal article" date="2004" name="J. Mol. Biol." volume="338" first="745" last="755">
            <title>A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Isermann K."/>
                <person name="Liebau E."/>
                <person name="Roeder T."/>
                <person name="Bruchhaus I."/>
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        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="19839" last="19844">
            <title>A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.</title>
            <authorList>
                <person name="Olahova M."/>
                <person name="Taylor S.R."/>
                <person name="Khazaipoul S."/>
                <person name="Wang J."/>
                <person name="Morgan B.A."/>
                <person name="Matsumoto K."/>
                <person name="Blackwell T.K."/>
                <person name="Veal E.A."/>
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    <reference evidence="4" key="4">
        <citation type="journal article" date="2011" name="Antioxid. Redox Signal." volume="14" first="725" last="730">
            <title>Is overoxidation of peroxiredoxin physiologically significant?</title>
            <authorList>
                <person name="Thamsen M."/>
                <person name="Kumsta C."/>
                <person name="Li F."/>
                <person name="Jakob U."/>
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            <dbReference type="DOI" id="10.1089/ars.2010.3717"/>
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        <citation type="journal article" date="2011" name="Antioxid. Redox Signal." volume="14" first="1023" last="1037">
            <title>Effects of oxidative stress on behavior, physiology, and the redox thiol proteome of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kumsta C."/>
                <person name="Thamsen M."/>
                <person name="Jakob U."/>
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            <dbReference type="DOI" id="10.1089/ars.2010.3203"/>
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        <citation type="journal article" date="2014" name="BMC Biol." volume="12" first="64" last="64">
            <title>Genome-wide screening identifies new genes required for stress-induced phase 2 detoxification gene expression in animals.</title>
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                <person name="Crook-McMahon H.M."/>
                <person name="Olahova M."/>
                <person name="Button E.L."/>
                <person name="Winter J.J."/>
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        <citation type="journal article" date="2014" name="Proc. Natl. Acad. Sci. U.S.A." volume="111" first="E2501" last="E2509">
            <title>Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.</title>
            <authorList>
                <person name="De Haes W."/>
                <person name="Frooninckx L."/>
                <person name="Van Assche R."/>
                <person name="Smolders A."/>
                <person name="Depuydt G."/>
                <person name="Billen J."/>
                <person name="Braeckman B.P."/>
                <person name="Schoofs L."/>
                <person name="Temmerman L."/>
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            <dbReference type="DOI" id="10.1073/pnas.1321776111"/>
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        <citation type="journal article" date="2015" name="Aging Cell" volume="14" first="558" last="568">
            <title>A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity.</title>
            <authorList>
                <person name="Olahova M."/>
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            <dbReference type="DOI" id="10.1111/acel.12321"/>
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    <reference evidence="4" key="9">
        <citation type="journal article" date="2015" name="Neuron" volume="85" first="804" last="818">
            <title>Light and hydrogen peroxide inhibit C. elegans Feeding through gustatory receptor orthologs and pharyngeal neurons.</title>
            <authorList>
                <person name="Bhatla N."/>
                <person name="Horvitz H.R."/>
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            <dbReference type="DOI" id="10.1016/j.neuron.2014.12.061"/>
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        <scope>FUNCTION</scope>
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        <citation type="journal article" date="2018" name="Redox Biol." volume="14" first="386" last="390">
            <title>Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin?</title>
            <authorList>
                <person name="Henderson D."/>
                <person name="Huebner C."/>
                <person name="Markowitz M."/>
                <person name="Taube N."/>
                <person name="Harvanek Z.M."/>
                <person name="Jakob U."/>
                <person name="Knoefler D."/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TEA/ATTS_sf"/>
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        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
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        <property type="entry name" value="TEF_metazoa"/>
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        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
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        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="10">
        <location>
            <begin position="88"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="8">
        <location>
            <begin position="88"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SOF58759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F28B12.2i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C2P8"/>
        </source>
    </evidence>
    <sequence length="493" mass="54501" checksum="4E5095E66E01F714" modified="2017-12-20" version="1">MNSMFCSELQQALPQMSEDVAVTAQTILNGTPPHNHFRKEWLAGAAGTTTPTTTSGGQMMTLSPPAGDGPGSAGSMAPESTSSLSDLSGDAEGVWSIDIDQAFQEALAIYPPCGRRKIIISDEGKMYGRNELIARYIKLRCGKTRTRKQVSSHIQVLARKKLRDEQAKKKVPFHLNTGDIPSLLQQASPPGGVKSPSAVVFPPVSAAVAAITEISPQSSYSSIVPKVETDQISQQLFKSLPLWSFQQTPGLPIGMDLSQLVFQQSSPDKTVSPVKSEVVEETKPIASSQLTLHSFSAYVKCNKTSLRTELVKIENTLEKDDIDISVFYEKYPKLLRELFEKSEKKDVFFLAKCWANINVSDDVQNCQYAVDSFYSSREKFQLKVSTMACSFGNQAVEKIEQYFPIEFDGSYSFILNNSPMCDYMVKFIAELKKLNVIETMNNVLENFTVLQIVTNSETDELLMVLCFVFEVSQEPEPSCSVYRLIDGGGDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C301</accession>
    <name>A0A2C9C301_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F56D2.3</name>
        <name evidence="3 5" type="ORF">F56D2.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SOF58792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C301"/>
    <dbReference type="SMR" id="A0A2C9C301"/>
    <dbReference type="AGR" id="WB:WBGene00018965"/>
    <dbReference type="WormBase" id="F56D2.3b">
        <property type="protein sequence ID" value="CE52268"/>
        <property type="gene ID" value="WBGene00018965"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5810717at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018965">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C301">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SOF58792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F56D2.3b"/>
        </source>
    </evidence>
    <sequence length="195" mass="22396" checksum="9216C4EB311D7C72" modified="2017-12-20" version="1">MEKTDRERAMERAKPGFWRQNQRETMDRIKKIIGEQRMNMEQKQMHIRRVLANESDEIRSKFADIHKRLIMKNNKMTVSSPVPELSKQAKKLEKEAKKIMENKKMSVEKKQEKLDKLMLKAPENVKNELNAMNDSGSTPAPIQAPFPAPGQTEALNRANPSMASQVEVMTRNAPTQAVVEARQIRVSEDGKTVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C306</accession>
    <name>A0A2C9C306_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C23H3.9</name>
        <name evidence="2" type="ORF">CELE_C23H3.9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343749.1">
        <property type="nucleotide sequence ID" value="NM_001356827.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C306"/>
    <dbReference type="SMR" id="A0A2C9C306"/>
    <dbReference type="GeneID" id="173391"/>
    <dbReference type="AGR" id="WB:WBGene00016022"/>
    <dbReference type="CTD" id="173391"/>
    <dbReference type="WormBase" id="C23H3.9f">
        <property type="protein sequence ID" value="CE52152"/>
        <property type="gene ID" value="WBGene00016022"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016022">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C306">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200:SF49">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C23H3.9f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C306"/>
        </source>
    </evidence>
    <sequence length="196" mass="22278" checksum="B9F3FC9832A7F946" modified="2017-12-20" version="1">MDNAFYHQRQENSRWILQSHLLLLSNGLAKESVTLDQIDSVVITHASPGHMGNMNFFAQKPILYHSMEYIGRHVTPTELKERPYRKLSGNVEVWKTPGHTQHDLSVLVHNVAGYGTMAIVGDLIPSEHLLSEKRDVMIEEGVWDNAIKRQNANLIVCMADWIVPGHGQPFRVLPNYRQKAGCTRLLAQRHLLNQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C312</accession>
    <name>A0A2C9C312_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ceh-22</name>
        <name evidence="11" type="ORF">CELE_F29F11.5</name>
        <name evidence="13" type="ORF">F29F11.5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343842.1">
        <property type="nucleotide sequence ID" value="NM_001356739.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C312"/>
    <dbReference type="SMR" id="A0A2C9C312"/>
    <dbReference type="GeneID" id="179485"/>
    <dbReference type="AGR" id="WB:WBGene00000445"/>
    <dbReference type="CTD" id="179485"/>
    <dbReference type="WormBase" id="F29F11.5e">
        <property type="protein sequence ID" value="CE52381"/>
        <property type="gene ID" value="WBGene00000445"/>
        <property type="gene designation" value="ceh-22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000445">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C312">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000101">
        <property type="entry name" value="NK2 homeobox 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF82">
        <property type="entry name" value="HOMEOBOX PROTEIN VND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="101"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="103"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SOF58842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F29F11.5e"/>
        </source>
    </evidence>
    <sequence length="260" mass="28978" checksum="45C46D779660DE94" modified="2017-12-20" version="1">MQLASETRVFPVSGYSATPTFSFDPCTYGSYDPSAYFASNGIAGSMYTLPDQFPRSENDMLDNSNTSNGNKSDKDGIKLEDEDEILEDEENDEEDDGTGKRKKRKRRVLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTDKPINAALLTTMPNAFSSQSTAASFPTRAMPIPMLVRDSSARSSDISSTSPYTVAFGSANSGYLPTPSAYLPATSGYFSNGPSAASSYMTNTQWWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C313</accession>
    <name>A0A2C9C313_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CYtochrome P450 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cyp-31a5</name>
        <name evidence="6" type="synonym">cyp-31A5</name>
        <name evidence="6" type="ORF">CELE_Y62E10A.15</name>
        <name evidence="8" type="ORF">Y62E10A.15</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="SOF58802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343806.1">
        <property type="nucleotide sequence ID" value="NM_001356936.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C313"/>
    <dbReference type="SMR" id="A0A2C9C313"/>
    <dbReference type="GeneID" id="13198891"/>
    <dbReference type="AGR" id="WB:WBGene00013381"/>
    <dbReference type="WormBase" id="Y62E10A.15c">
        <property type="protein sequence ID" value="CE52285"/>
        <property type="gene ID" value="WBGene00013381"/>
        <property type="gene designation" value="cyp-31A5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013381">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C313">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF194">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SOF58802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y62E10A.15c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C313"/>
        </source>
    </evidence>
    <sequence length="293" mass="33764" checksum="7B4B9202E3AD3419" modified="2017-12-20" version="1">MGVIIPAVLLASATVIAWLIYKHLRMRQVLKHLNQPRSYPIVGHGLITKPDPEGFMNQVIGMGYLYPDPRMCLLWIGPFPCLMLYSADLVEPIFSSTKHLNKGFAYVLLEPWLGISILTSQKEQWRPKRKLLTPTFHYDILKDFLPIFNEQSKILIQKLCCLGVADEEVDVLSVITLCTLDIICETSMGKAIGAQLAENNEYVWAVHTINKLISKRTNNPLMWNSFIYNLTEDGRTHEKCLHILHDFTKKVIVERKEALQDSDYKMEGRLAFSRQICCTIRILRILCSRNRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C318</accession>
    <name>A0A2C9C318_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">vhp-1</name>
        <name evidence="8" type="ORF">CELE_F08B1.1</name>
        <name evidence="10" type="ORF">F08B1.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001427167.1">
        <property type="nucleotide sequence ID" value="NM_001440236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C318"/>
    <dbReference type="SMR" id="A0A2C9C318"/>
    <dbReference type="GeneID" id="173904"/>
    <dbReference type="AGR" id="WB:WBGene00006923"/>
    <dbReference type="CTD" id="173904"/>
    <dbReference type="WormBase" id="F08B1.1f">
        <property type="protein sequence ID" value="CE52123"/>
        <property type="gene ID" value="WBGene00006923"/>
        <property type="gene designation" value="vhp-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006923">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C318">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14568">
        <property type="entry name" value="DSP_MKP_classIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF533">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE VHP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="83"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SOF58746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F08B1.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C318"/>
        </source>
    </evidence>
    <sequence length="502" mass="53359" checksum="8C2D8418C02E26BE" modified="2017-12-20" version="1">MTRLPQSLSQPCLSQPTGDGITLITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIKDHVLDYNQASRPHRHMDYYGPSDLCPPKVPKSASSNCVFPGSTHDESSPSSPSVSEGSAASEPETSSSAASSSSTASAPPSMPSTSEQGTSSGTVNVNGKRNMTMDLGLPHRPKALGLPSRIGTSVAELPSPSTELSRLSFNGPEAIAPSTPILNFTNPCFNSPIIPVASSSREVILTLPTPAASSSSSTSSEPSFDFSSFESSSSSSIVVENPFFASTEVPAGSSSISTPSGSQSTPASASSSAASRCRMKGFFKVFSKKAPASTSTPASSTPGTSRAARPECLRSSGIIISAPVLAITEEEDAESPESGFNEPEVGEEDDDSVSICSTSSLEIPCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3M6</accession>
    <name>A0A2C9C3M6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srm-3</name>
        <name evidence="2" type="ORF">CELE_F58G6.2</name>
        <name evidence="4" type="ORF">F58G6.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="SOF58799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380225.1">
        <property type="nucleotide sequence ID" value="NM_001392372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3M6"/>
    <dbReference type="SMR" id="A0A2C9C3M6"/>
    <dbReference type="GeneID" id="186545"/>
    <dbReference type="AGR" id="WB:WBGene00010273"/>
    <dbReference type="CTD" id="186545"/>
    <dbReference type="WormBase" id="F58G6.2c">
        <property type="protein sequence ID" value="CE52128"/>
        <property type="gene ID" value="WBGene00010273"/>
        <property type="gene designation" value="srm-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5792363at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010273">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3M6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47758:SF2">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47758">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F58G6.2c"/>
        </source>
    </evidence>
    <sequence length="92" mass="10581" checksum="CF1A4E73954B51A2" modified="2017-12-20" version="1">MTLLLQFILPFVTIHVPFYIIVILPFFRIAGRVLSDHLLLLFCWCPAINPILVILMIKNVQDQLIPKKFSKTSTMSKLSQAQSKSIRVINLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3P4</accession>
    <name>A0A2C9C3P4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Seven TM Receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">str-118</name>
        <name evidence="2" type="ORF">CELE_F57A8.3</name>
        <name evidence="4" type="ORF">F57A8.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343849.1">
        <property type="nucleotide sequence ID" value="NM_001356735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C3P4"/>
    <dbReference type="GeneID" id="186429"/>
    <dbReference type="AGR" id="WB:WBGene00006169"/>
    <dbReference type="CTD" id="186429"/>
    <dbReference type="WormBase" id="F57A8.3c">
        <property type="protein sequence ID" value="CE52361"/>
        <property type="gene ID" value="WBGene00006169"/>
        <property type="gene designation" value="str-118"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5818029at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3P4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF26">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F57A8.3c"/>
        </source>
    </evidence>
    <sequence length="319" mass="36545" checksum="8CD093A1F2CEC666" modified="2017-12-20" version="1">MVYSTWSTVTHIFGWFSFFTAIWATITLFVLIEKKSRKEFGGYKNFLRVYCFYAFIFSTIDWVVQPYAVMDINGLGYVFYSENRLFDLGYSLSHLLQILYCGCFIASSSFLSLNFIYRYVSSCHSHYLHYIQDFGLILIIAYCILPFVIWSICVYYIFSPTSEKTEYINMSTMQIENFNISGNPYVGVICYYILTTPLHNYGDVDWWTMGALLGLIIFQAVVPLVSVYVPTAIMIGGGMVGIYMGEIGHFVVMSISIYPPLDSVVFLLSIRDFRNALFCNSKIDNRGDSSNIRPGTAKISDILTRRLNYQQPAIPTLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C3P6</accession>
    <name>A0A2C9C3P6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Ryanodine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">unc-68</name>
        <name evidence="20" type="ORF">CELE_K11C4.5</name>
        <name evidence="22" type="ORF">K11C4.5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343812.1">
        <property type="nucleotide sequence ID" value="NM_001356687.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2C9C3P6"/>
    <dbReference type="PaxDb" id="6239-K11C4.5c"/>
    <dbReference type="GeneID" id="179080"/>
    <dbReference type="AGR" id="WB:WBGene00006801"/>
    <dbReference type="CTD" id="179080"/>
    <dbReference type="WormBase" id="K11C4.5i">
        <property type="protein sequence ID" value="CE52127"/>
        <property type="gene ID" value="WBGene00006801"/>
        <property type="gene designation" value="unc-68"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300855at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006801">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C3P6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23278">
        <property type="entry name" value="beta-trefoil_MIR_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12877">
        <property type="entry name" value="SPRY1_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12878">
        <property type="entry name" value="SPRY2_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000052">
        <property type="entry name" value="CBN-UNC-68 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000006">
        <property type="entry name" value="Protein CBR-LIPL-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000132">
        <property type="entry name" value="Ryanodine receptor 44F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000017">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000003">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000003">
        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000022">
        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000021">
        <property type="entry name" value="Ryanodine receptor, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
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    <sequence length="5199" mass="590833" checksum="8F4258D299B89726" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P6P962</accession>
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        <submittedName>
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    <organism evidence="2 3">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
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    <reference key="2">
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            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
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    <dbReference type="WormBase" id="C01A2.2b">
        <property type="protein sequence ID" value="CE42735"/>
        <property type="gene ID" value="WBGene00007214"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1210974_0_0_1"/>
    <dbReference type="OrthoDB" id="5868674at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007214">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFW7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002800015" evidence="2">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAQ76454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C01A2.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="B3WFW7"/>
        </source>
    </evidence>
    <sequence length="83" mass="9517" checksum="9058025F2F13701F" modified="2008-09-02" version="1">MTNFILNCIFTILTLGAFAMDVHRRVFGNIRFDLGWTAFQICFTAAQGLAIYVVMRGRKYVAAKSFWMNKYNQRTGPDDIIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B3WFW8</accession>
    <name>B3WFW8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRKC apoptosis WT1 regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C17E4.10</name>
        <name evidence="2" type="ORF">CELE_C17E4.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAQ76457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129753.1">
        <property type="nucleotide sequence ID" value="NM_001136281.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3WFW8"/>
    <dbReference type="SMR" id="B3WFW8"/>
    <dbReference type="GeneID" id="172770"/>
    <dbReference type="KEGG" id="cel:CELE_C17E4.10"/>
    <dbReference type="AGR" id="WB:WBGene00007647"/>
    <dbReference type="CTD" id="172770"/>
    <dbReference type="WormBase" id="C17E4.10b">
        <property type="protein sequence ID" value="CE42778"/>
        <property type="gene ID" value="WBGene00007647"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052233_0_0_1"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007647">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFW8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAQ76457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C17E4.10b"/>
        </source>
    </evidence>
    <sequence length="142" mass="16341" checksum="87C3EC7D7BADA144" modified="2008-09-02" version="1">MVFGWNAKSNKEQLEKPTSLPLHYELEADCSTPRRAEFSMNPEDDYENQSEDATPATSSGEEGVLQQSLLQLQKQLRKTDVRCSRLEKICEFQQRDIDSLRFEVDWKDKRIEFLQKTLQEIETSTSQSDAPNTSRSTTTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>B3WFW9</accession>
    <name>B3WFW9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TspO/MBR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tspo-1</name>
        <name evidence="9" type="ORF">C41G7.9</name>
        <name evidence="7" type="ORF">CELE_C41G7.9</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAQ76462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001251117.1">
        <property type="nucleotide sequence ID" value="NM_001264188.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3WFW9"/>
    <dbReference type="SMR" id="B3WFW9"/>
    <dbReference type="PeptideAtlas" id="B3WFW9"/>
    <dbReference type="GeneID" id="7040157"/>
    <dbReference type="AGR" id="WB:WBGene00077771"/>
    <dbReference type="CTD" id="7040157"/>
    <dbReference type="WormBase" id="C41G7.9a">
        <property type="protein sequence ID" value="CE42828"/>
        <property type="gene ID" value="WBGene00077771"/>
        <property type="gene designation" value="tspo-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091805_1_0_1"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="PhylomeDB" id="B3WFW9"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00077771">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFW9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000003">
        <property type="entry name" value="Protein CBG24492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAQ76462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C41G7.9a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="B3WFW9"/>
        </source>
    </evidence>
    <sequence length="171" mass="18613" checksum="C5809BD9590A5E21" modified="2008-09-02" version="1">MPFWTTQDTRNAIISSLIPAGAAVAAFASFAKDQQVADWWAALKKPNWAPKDVRVYSAVDLLTLSPLGYASYLVYKNGGGFDYNDTKLALGLYGASVTLAVATIPIVKKKELGCLWKNTTVVSLTAAAASFAFYKIDKKAGLLVVPFAVWTAFYAYLAYSIKKENDPIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>B3WFX4</accession>
    <name>B3WFX4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein lin-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">lin-10</name>
        <name evidence="9" type="ORF">C09H6.2</name>
        <name evidence="7" type="ORF">CELE_C09H6.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAQ76455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129749.1">
        <property type="nucleotide sequence ID" value="NM_001136277.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3WFX4"/>
    <dbReference type="SMR" id="B3WFX4"/>
    <dbReference type="PeptideAtlas" id="B3WFX4"/>
    <dbReference type="GeneID" id="172597"/>
    <dbReference type="AGR" id="WB:WBGene00002999"/>
    <dbReference type="CTD" id="172597"/>
    <dbReference type="WormBase" id="C09H6.2c">
        <property type="protein sequence ID" value="CE42752"/>
        <property type="gene ID" value="WBGene00002999"/>
        <property type="gene designation" value="lin-10"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5987010at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002999">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFX4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd06720">
        <property type="entry name" value="PDZ1_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06793">
        <property type="entry name" value="PDZ2_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01208">
        <property type="entry name" value="PTB_X11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000007">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000207">
        <property type="entry name" value="Protein CBR-LIN-10, isoform a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF16">
        <property type="entry name" value="X11L, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
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    </dbReference>
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        <property type="entry name" value="PID"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
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            <end position="737"/>
        </location>
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        <location>
            <begin position="750"/>
            <end position="835"/>
        </location>
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    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="841"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAQ76455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C09H6.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="B3WFX4"/>
        </source>
    </evidence>
    <sequence length="931" mass="100497" checksum="4CE314664A028CB8" modified="2008-09-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>B3WFX6</accession>
    <name>B3WFX6_CAEEL</name>
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        <submittedName>
            <fullName evidence="8">RING finger and SPRY domain-containing protein 1</fullName>
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        <name evidence="8" type="ORF">CELE_F16A11.1</name>
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    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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    <dbReference type="RefSeq" id="NP_001129765.1">
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    <dbReference type="PeptideAtlas" id="B3WFX6"/>
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    <dbReference type="KEGG" id="cel:CELE_F16A11.1"/>
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    <dbReference type="CTD" id="172764"/>
    <dbReference type="WormBase" id="F16A11.1b">
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        <property type="gene ID" value="WBGene00008876"/>
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    <dbReference type="HOGENOM" id="CLU_026400_0_0_1"/>
    <dbReference type="OrthoDB" id="10017393at2759"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008876">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFX6">
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    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAQ76470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F16A11.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="B3WFX6"/>
        </source>
    </evidence>
    <sequence length="621" mass="70621" checksum="69656D9CB3789EB7" modified="2008-09-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B3WFX7</accession>
    <name>B3WFX7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F33H2.8</name>
        <name evidence="2 4" type="ORF">F33H2.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAQ76475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129770.1">
        <property type="nucleotide sequence ID" value="NM_001136298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3WFX7"/>
    <dbReference type="GeneID" id="185238"/>
    <dbReference type="KEGG" id="cel:CELE_F33H2.8"/>
    <dbReference type="AGR" id="WB:WBGene00009371"/>
    <dbReference type="CTD" id="185238"/>
    <dbReference type="WormBase" id="F33H2.8b">
        <property type="protein sequence ID" value="CE42781"/>
        <property type="gene ID" value="WBGene00009371"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_903780_0_0_1"/>
    <dbReference type="OrthoDB" id="5867030at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009371">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFX7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAQ76475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F33H2.8b"/>
        </source>
    </evidence>
    <sequence length="169" mass="18863" checksum="71107584392724C9" modified="2008-09-02" version="1">MIAPLAIAVSIAWLEPGQMEYTGVSLMSAFLLPISRALSFILLKNSMDCLGKGHINAFMLEYTRFVTILLFLPALVSYLLSSVEVTASWESIDYVLMSLSFIFMICNLYSHLWLTLSLSPSVYLVLENSRNLLASCAQWIIQNMAHPSLIAFGGKIVGFAAIFRIWTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B3WFX8</accession>
    <name>B3WFX8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Actin-binding Rho-activating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Striated muscle activator of Rho-dependent signaling</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CELE_F36F2.1</name>
        <name evidence="19 21" type="ORF">F36F2.1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Binds F-actin and ABLIM1, ABLIM2 and ABLIM3. Interaction with ABLIM2 and ABLIM3 enhances activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAQ76476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129772.1">
        <property type="nucleotide sequence ID" value="NM_001136300.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3WFX8"/>
    <dbReference type="SMR" id="B3WFX8"/>
    <dbReference type="PeptideAtlas" id="B3WFX8"/>
    <dbReference type="GeneID" id="172722"/>
    <dbReference type="KEGG" id="cel:CELE_F36F2.1"/>
    <dbReference type="AGR" id="WB:WBGene00009475"/>
    <dbReference type="CTD" id="172722"/>
    <dbReference type="WormBase" id="F36F2.1b">
        <property type="protein sequence ID" value="CE42715"/>
        <property type="gene ID" value="WBGene00009475"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062244_2_0_1"/>
    <dbReference type="OrthoDB" id="9871914at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009475">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFX8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1540:FF:000001">
        <property type="entry name" value="Actin-binding Rho-activating protein a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1540">
        <property type="entry name" value="Costar domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026111">
        <property type="entry name" value="Abra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027817">
        <property type="entry name" value="Costars_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038095">
        <property type="entry name" value="Costars_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22739:SF18">
        <property type="entry name" value="COSTARS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22739">
        <property type="entry name" value="STRIATED MUSCLE ACTIVATOR OF RHO-DEPENDENT SIGNALING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14705">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01283">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Costars" evidence="18">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAQ76476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WormBase" id="F36F2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PeptideAtlas" id="B3WFX8"/>
        </source>
    </evidence>
    <sequence length="145" mass="16507" checksum="76C17F8AD81CA868" modified="2008-09-02" version="1">MEQNVATQSKDDVYSKDFTQKKMDKSSSEYGRPKPGTLTEQRAKKAAAHVHREMLTLCEVVEDYGKQEKEGDPIRITFGRLFTIYVNISDKVVGTLLRARKHKMIDFEGEMLFQKRDDHVIITLLLSGAQLKEAIRAHAAANPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B3WFY3</accession>
    <name>B3WFY3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_W09G3.6</name>
        <name evidence="2 4" type="ORF">W09G3.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAQ76499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129796.1">
        <property type="nucleotide sequence ID" value="NM_001136324.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3WFY3"/>
    <dbReference type="PeptideAtlas" id="B3WFY3"/>
    <dbReference type="GeneID" id="173249"/>
    <dbReference type="KEGG" id="cel:CELE_W09G3.6"/>
    <dbReference type="AGR" id="WB:WBGene00012369"/>
    <dbReference type="CTD" id="173249"/>
    <dbReference type="WormBase" id="W09G3.6b">
        <property type="protein sequence ID" value="CE42763"/>
        <property type="gene ID" value="WBGene00012369"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004856_0_0_1"/>
    <dbReference type="OrthoDB" id="19493at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012369">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFY3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAQ76499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="W09G3.6b"/>
        </source>
    </evidence>
    <sequence length="66" mass="7020" checksum="9DEAB492745F8ADF" modified="2008-09-02" version="1">MVVGGADRGVISYFCGHVYHKICLTGRFNAGCVACRVRARRATRAGSSATSSPVASPIMSPRHQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>B3WFY7</accession>
    <name>B3WFY7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyroglutamyl-peptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CELE_M04C9.3</name>
        <name evidence="6 8" type="ORF">M04C9.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAQ76488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129785.1">
        <property type="nucleotide sequence ID" value="NM_001136313.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3WFY7"/>
    <dbReference type="SMR" id="B3WFY7"/>
    <dbReference type="MEROPS" id="C15.A04"/>
    <dbReference type="PeptideAtlas" id="B3WFY7"/>
    <dbReference type="GeneID" id="187440"/>
    <dbReference type="KEGG" id="cel:CELE_M04C9.3"/>
    <dbReference type="AGR" id="WB:WBGene00010858"/>
    <dbReference type="CTD" id="187440"/>
    <dbReference type="WormBase" id="M04C9.3b">
        <property type="protein sequence ID" value="CE42727"/>
        <property type="gene ID" value="WBGene00010858"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043960_2_0_1"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010858">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFY7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.20:FF:000007">
        <property type="entry name" value="Protein CBG22077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010381">
        <property type="entry name" value="PgaPase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06162">
        <property type="entry name" value="PgaPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAQ76488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="M04C9.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="B3WFY7"/>
        </source>
    </evidence>
    <sequence length="201" mass="22436" checksum="D809F6D1AD125483" modified="2008-09-02" version="1">MKKKVVVTGFGPFRGFEEENPSSIIIDELTKNGISGVDLELHKITVAYEDVSKKVPELWNEHKPDLVIHLGAHPVEKTIKFEQQAFSNGYCSNDVNGCTPADNKTSCSSEHETLVSCINCDFLVTKVTEKCALDGQKYSGLCVKKSEDPGRYLCGFSYFLSLHEDCSKSLFIHVPAFKEECTKEAVTEVIRETINTILFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-02-10" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>B7CED8</accession>
    <name>B7CED8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 23" type="primary">mca-3</name>
        <name evidence="21" type="ORF">CELE_Y67D8C.10</name>
        <name evidence="23" type="ORF">Y67D8C.10</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD74104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255244.1">
        <property type="nucleotide sequence ID" value="NM_001268315.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B7CED8"/>
    <dbReference type="SMR" id="B7CED8"/>
    <dbReference type="PeptideAtlas" id="B7CED8"/>
    <dbReference type="GeneID" id="177089"/>
    <dbReference type="KEGG" id="cel:CELE_Y67D8C.10"/>
    <dbReference type="AGR" id="WB:WBGene00003153"/>
    <dbReference type="CTD" id="177089"/>
    <dbReference type="WormBase" id="Y67D8C.10d">
        <property type="protein sequence ID" value="CE43364"/>
        <property type="gene ID" value="WBGene00003153"/>
        <property type="gene designation" value="mca-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_2_1"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003153">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B7CED8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051481">
        <property type="term" value="P:negative regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040010">
        <property type="term" value="P:positive regulation of growth rate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000013">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000060">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000007">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="887"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="971"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1009"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1041"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1074"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1150"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1157"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCD74104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WormBase" id="Y67D8C.10d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PeptideAtlas" id="B7CED8"/>
        </source>
    </evidence>
    <sequence length="1170" mass="128743" checksum="FB471A93DABBE643" modified="2009-02-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-02" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D2YW04</accession>
    <name>D2YW04_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_W02B12.13</name>
        <name evidence="3 5" type="ORF">W02B12.13</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="3 4" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="WBGene00043534"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBI83237.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W02B12.13b"/>
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</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="CBI83231.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F09A5.3b"/>
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    </evidence>
    <sequence length="236" mass="28051" checksum="C6037B7BD8BD744D" modified="2010-03-02" version="1">MKEVEVAFMEQDTISNVLRGGHGEWCEMFKDNANEMDAHMCFIKNSVFRAAVVMQFIYNCTMSVFRCCRNRMLHHFLIDPLGRIIPENGDYVHKIITNPRFHFARLLRSSLRILEHEIQRIEFTRECIHEFIQFLNLQLPQVGLTNKNLNQKVALEKRTDLEAIAKQHSFLWKNYKCWHNKNLNFLLTTERLMACNLCKIIRMRDMHVVVLNNWTDFSVIPAPLHPRNFESLFIKL</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="Bgee" id="WBGene00012306">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D2YW10">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="40"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
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            <begin position="337"/>
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        </location>
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        <location>
            <begin position="365"/>
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            <end position="489"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBI83238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W06F12.2d"/>
        </source>
    </evidence>
    <sequence length="566" mass="65720" checksum="8E513DCD2E67B1F3" modified="2010-03-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-07-13" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>D6R8W5</accession>
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        <submittedName>
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        <name evidence="10" type="ORF">C50F4.14</name>
        <name evidence="8" type="ORF">CELE_C50F4.14</name>
    </gene>
    <organism evidence="8 9">
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            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBL87050.1"/>
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    <dbReference type="SMR" id="D6R8W5"/>
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    <dbReference type="AGR" id="WB:WBGene00008237"/>
    <dbReference type="CTD" id="179342"/>
    <dbReference type="WormBase" id="C50F4.14b">
        <property type="protein sequence ID" value="CE44998"/>
        <property type="gene ID" value="WBGene00008237"/>
        <property type="gene designation" value="nstp-10"/>
    </dbReference>
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        <property type="component" value="Chromosome V"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
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    <proteinExistence type="evidence at protein level"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="159"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
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    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
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            <begin position="19"/>
            <end position="309"/>
        </location>
    </feature>
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        <location>
            <begin position="320"/>
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    </feature>
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        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBL87050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="C50F4.14b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="D6R8W5"/>
        </source>
    </evidence>
    <sequence length="349" mass="38746" checksum="432AD7565C1CE137" modified="2010-07-13" version="1">MRNRENPTKWESYKQVITAVSAYWVFSIGLVFLNKYLLSSVQLDAPLFITWYQCLVTVFLCLFLSKTSKAYGLFKFPSMPIDAKISREVLPLSVVFVAMISFNNLCLKYVGVSFYYVGRSLTTVFNVVCTYLILGQKTSGQAIGCCALIIFGFLLGVDQEGVTGTLSYTGVIFGVLASLSVALNAIYTRKVLSSVGDCLWRLTMYNNLNALVLFLPLMLFNGEFGAVFYFDKLFDTTFWILMTLGGVFGFMMGYVTGWQIQATSPLTHNISGTAKAAAQTVMAVVWYSELKTLLWWTSNFVVLFGSGMYTYVQKRVMDKKNSGASPASEAKSDKVKLLGRDGNAAEESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-07-13" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D6R8W6</accession>
    <name>D6R8W6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_K06A4.2</name>
        <name evidence="3 5" type="ORF">K06A4.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBL87055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256120.1">
        <property type="nucleotide sequence ID" value="NM_001269191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D6R8W6"/>
    <dbReference type="GeneID" id="187046"/>
    <dbReference type="AGR" id="WB:WBGene00010592"/>
    <dbReference type="CTD" id="187046"/>
    <dbReference type="WormBase" id="K06A4.2b">
        <property type="protein sequence ID" value="CE06106"/>
        <property type="gene ID" value="WBGene00010592"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060812_0_0_1"/>
    <dbReference type="OrthoDB" id="5804124at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010592">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D6R8W6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL87055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K06A4.2b"/>
        </source>
    </evidence>
    <sequence length="220" mass="25707" checksum="8AA29B4DA946F38B" modified="2010-07-13" version="1">MSNSPRVPRNLSVRTKDQQNVEANDDGNASRRGIDNTQTWPFFNPSTRFRLLKIIFVLMCLVDIMHWAYLLRDDTNENPNSWRFYKKFKSFDLYYLVARMFADIFTCVLGLGAAMWTRKPLLTLPCTTIQLLFLLIRAAVWSVRSYNRLLEKLHATNEDKVFVICEFALPAIWALLSFLIVHTTRRLRCYEQLHGYARPPIIVLTVKNDDNDESVQIEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-07-13" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D6R8W7</accession>
    <name>D6R8W7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MIF-like protein mif-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mif-2</name>
        <name evidence="4" type="ORF">C52E4.2</name>
        <name evidence="2" type="ORF">CELE_C52E4.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBL87051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256387.1">
        <property type="nucleotide sequence ID" value="NM_001269458.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D6R8W7"/>
    <dbReference type="SMR" id="D6R8W7"/>
    <dbReference type="PeptideAtlas" id="D6R8W7"/>
    <dbReference type="GeneID" id="179638"/>
    <dbReference type="KEGG" id="cel:CELE_C52E4.2"/>
    <dbReference type="AGR" id="WB:WBGene00003235"/>
    <dbReference type="CTD" id="179638"/>
    <dbReference type="WormBase" id="C52E4.2b">
        <property type="protein sequence ID" value="CE44888"/>
        <property type="gene ID" value="WBGene00003235"/>
        <property type="gene designation" value="mif-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129906_2_2_1"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003235">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D6R8W7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019829">
        <property type="entry name" value="Macrophage_inhib_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF37">
        <property type="entry name" value="MIF-LIKE PROTEIN MIF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01158">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBL87051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C52E4.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="D6R8W7"/>
        </source>
    </evidence>
    <sequence length="90" mass="9434" checksum="A7B5126670D14272" modified="2010-07-13" version="1">MGKPRERIAVEIAAGARLVHGATHDPVTVISIKSIGAVSAEDNIRNTAAITEFCGKELGLPKDKVVITFHDLPPATVGFNGTTVAEANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-07-13" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>D6R8W9</accession>
    <name>D6R8W9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rbc-1</name>
        <name evidence="4" type="ORF">CELE_F54E4.1</name>
        <name evidence="6" type="ORF">F54E4.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CBL87054.4"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379518.1">
        <property type="nucleotide sequence ID" value="NM_001392889.1"/>
    </dbReference>
    <dbReference type="SMR" id="D6R8W9"/>
    <dbReference type="PeptideAtlas" id="D6R8W9"/>
    <dbReference type="GeneID" id="181558"/>
    <dbReference type="AGR" id="WB:WBGene00004313"/>
    <dbReference type="CTD" id="181558"/>
    <dbReference type="WormBase" id="F54E4.1a">
        <property type="protein sequence ID" value="CE47867"/>
        <property type="gene ID" value="WBGene00004313"/>
        <property type="gene designation" value="rbc-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000267_0_0_1"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004313">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D6R8W9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002900">
        <property type="entry name" value="Protein CBR-RBC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="3">
        <location>
            <begin position="1219"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="3">
        <location>
            <begin position="1566"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="2728"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="2867"/>
            <end position="2908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1378"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1943"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2080"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2353"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2440"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2080"/>
            <end position="2093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2094"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2377"/>
            <end position="2387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2440"/>
            <end position="2467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBL87054.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F54E4.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="D6R8W9"/>
        </source>
    </evidence>
    <sequence length="3012" mass="337082" checksum="F159786A70D2490F" modified="2013-02-06" version="4"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-07-13" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>D6R8X0</accession>
    <name>D6R8X0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dipeptidyl peptidase family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">dpf-1</name>
        <name evidence="17" type="ORF">CELE_T23F1.7</name>
        <name evidence="19" type="ORF">T23F1.7</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Removes N-terminal dipeptides sequentially from polypeptides. Essential for control of distal tip cell migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family. DPPIV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBL87058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256667.1">
        <property type="nucleotide sequence ID" value="NM_001269738.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D6R8X0"/>
    <dbReference type="SMR" id="D6R8X0"/>
    <dbReference type="ESTHER" id="caeel-T23F1.7">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.A76"/>
    <dbReference type="PeptideAtlas" id="D6R8X0"/>
    <dbReference type="GeneID" id="180042"/>
    <dbReference type="AGR" id="WB:WBGene00001054"/>
    <dbReference type="CTD" id="180042"/>
    <dbReference type="WormBase" id="T23F1.7c">
        <property type="protein sequence ID" value="CE44934"/>
        <property type="gene ID" value="WBGene00001054"/>
        <property type="gene designation" value="dpf-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_4_0_1"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001054">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D6R8X0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012203836" evidence="14">
        <location>
            <begin position="16"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="16">
        <location>
            <begin position="106"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="15">
        <location>
            <begin position="549"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBL87058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="T23F1.7c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="D6R8X0"/>
        </source>
    </evidence>
    <sequence length="739" mass="84690" checksum="C463EC01A76A88CC" modified="2010-07-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-07-13" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D6R8X6</accession>
    <name>D6R8X6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF281 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F49C5.11</name>
        <name evidence="3 5" type="ORF">F49C5.11</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CBL87052.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254346.1">
        <property type="nucleotide sequence ID" value="NM_001267417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D6R8X6"/>
    <dbReference type="PeptideAtlas" id="D6R8X6"/>
    <dbReference type="GeneID" id="3565943"/>
    <dbReference type="AGR" id="WB:WBGene00044163"/>
    <dbReference type="CTD" id="3565943"/>
    <dbReference type="WormBase" id="F49C5.11b">
        <property type="protein sequence ID" value="CE47625"/>
        <property type="gene ID" value="WBGene00044163"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1556655_0_0_1"/>
    <dbReference type="OrthoDB" id="5906551at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044163">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D6R8X6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005098">
        <property type="entry name" value="DUF281"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36517:SF1">
        <property type="entry name" value="C6 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36517">
        <property type="entry name" value="PROTEIN CBG25732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03436">
        <property type="entry name" value="DUF281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087683" evidence="1">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DUF281" evidence="2">
        <location>
            <begin position="96"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL87052.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F49C5.11b"/>
        </source>
    </evidence>
    <sequence length="169" mass="18018" checksum="7D422D0FB8FB7A62" modified="2012-07-11" version="2">MYWPTLFLFICILLRPIESCMRMVPPDDVGFTTEEPALTTGLTEATTEPVTTATETESTTVAGDCRSCSIDEIKIPADDGGKKLISGDVPTDPTEDGCIQQKVVCQAPGGTLCESVTLVADTSTASVFIGPEDAFNSDATLTCNKDGTWSSGTTRDIEQIYCIFVEPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-07-13" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D6R8X7</accession>
    <name>D6R8X7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF281 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F49C5.11</name>
        <name evidence="3 5" type="ORF">F49C5.11</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CBL87053.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254347.1">
        <property type="nucleotide sequence ID" value="NM_001267418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D6R8X7"/>
    <dbReference type="GeneID" id="3565943"/>
    <dbReference type="AGR" id="WB:WBGene00044163"/>
    <dbReference type="CTD" id="3565943"/>
    <dbReference type="WormBase" id="F49C5.11a">
        <property type="protein sequence ID" value="CE47602"/>
        <property type="gene ID" value="WBGene00044163"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5906551at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044163">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D6R8X7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005098">
        <property type="entry name" value="DUF281"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36517:SF1">
        <property type="entry name" value="C6 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36517">
        <property type="entry name" value="PROTEIN CBG25732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03436">
        <property type="entry name" value="DUF281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087484" evidence="1">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="DUF281" evidence="2">
        <location>
            <begin position="93"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBL87053.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F49C5.11a"/>
        </source>
    </evidence>
    <sequence length="166" mass="17993" checksum="AE4F06DCE287575D" modified="2012-07-11" version="2">MYWPTLFLFICILLRPIESCMRMVPPDDVGFTTEEPALTTGLTEATTEPVTTATETESTTVAGDRAQLMKSRYQPMMEAKNLSQAIPTDPTEDGCIQQKVVCQAPGGTLCESVTLVADTSTASVFIGPEDAFNSDATLTCNKDGTWSSGTTRDIEQIYCIFVEPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFQ3</accession>
    <name>D7SFQ3_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_W04A8.6</name>
        <name evidence="3 5" type="ORF">W04A8.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CBM41235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFQ3"/>
    <dbReference type="SMR" id="D7SFQ3"/>
    <dbReference type="PeptideAtlas" id="D7SFQ3"/>
    <dbReference type="AGR" id="WB:WBGene00012241"/>
    <dbReference type="WormBase" id="W04A8.6b">
        <property type="protein sequence ID" value="CE45063"/>
        <property type="gene ID" value="WBGene00012241"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041200_0_0_1"/>
    <dbReference type="OrthoDB" id="5860225at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012241">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFQ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBM41235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W04A8.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D7SFQ3"/>
        </source>
    </evidence>
    <sequence length="307" mass="34284" checksum="CFF56800F331A234" modified="2010-08-10" version="1">MKTDVLKMLQEANERIEQLEKTRGNSHDDSSLLIPSYSLHDASSEGAGEALCYPDSGAAAQNPQNSMFMSIFSSNLVFSAQNSTQNAQNPMPKSLEDDLDAQDEVRVFRSSEDQEITDPEDFEEDETEELEISSSPFEVETSRSSSQQPGGEDSTIFEGNIRKIGGGRRHSDSDLFKGGPDTISLTPSDTVPVAPQNEYVRLQKYSRTNSWLKRNSINPDDDGGSSDSSEEERLSLIERQLKKKGGLVKYNPPRTKIHDKHYKRFGKNERSALAEFEYLQDMSTDVSGLQSSPELGQLMGQLQQQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFQ5</accession>
    <name>D7SFQ5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">dnj-25</name>
        <name evidence="3" type="ORF">CELE_W07A8.3</name>
        <name evidence="5" type="ORF">W07A8.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBM41237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256948.1">
        <property type="nucleotide sequence ID" value="NM_001270019.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFQ5"/>
    <dbReference type="SMR" id="D7SFQ5"/>
    <dbReference type="PeptideAtlas" id="D7SFQ5"/>
    <dbReference type="GeneID" id="180356"/>
    <dbReference type="AGR" id="WB:WBGene00001043"/>
    <dbReference type="CTD" id="180356"/>
    <dbReference type="WormBase" id="W07A8.3b">
        <property type="protein sequence ID" value="CE45060"/>
        <property type="gene ID" value="WBGene00001043"/>
        <property type="gene designation" value="dnj-25"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357622_0_0_1"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001043">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFQ5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="396"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
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        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBM41237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W07A8.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D7SFQ5"/>
        </source>
    </evidence>
    <sequence length="458" mass="50331" checksum="3637F339F3E6F53A" modified="2010-08-10" version="1">MDVSKMIASAMPVQDLRMIVNFATRRMPTLNTFQFDRYKLLCVRNDRELDGYQRSYGDVDSEDESPILRSARSKSGTKAAETSSSQGNFFDSLQFEDRQEPHHFREQRDSTLLDHHDDVTHHTADLLDGFTIGGTEKLSPANETPILSAPTPASSDYDSMTSSQNRRNPSPATAIDDLLGLGTETSAPAPAPSTHFNNSSSGANLVDFDLGAPIKPTSSASNLSTASPATSSWSNTDLLGGFSPMKPQTTSTPPNTRNPSASNSKPVSQVNSQADFEAFLSNYPEQRQAAPQNTQNVSQKTQQTRPQNTYKPAFGDAATGSAKVSMDAFSDLLNQGGFKPTQRENQKQSIGNMLKVEQSKNLTPEEIQIRDWTQGKERNIRALLGSLHNVLWEGADRWNQPSMGDLLTPDQIKKHYRKACLVVHPDKLTGSPHLSLAKMAFTELNDAYSKYQNDPAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFQ6</accession>
    <name>D7SFQ6_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">dnj-25</name>
        <name evidence="3" type="ORF">CELE_W07A8.3</name>
        <name evidence="5" type="ORF">W07A8.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBM41238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256949.1">
        <property type="nucleotide sequence ID" value="NM_001270020.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFQ6"/>
    <dbReference type="SMR" id="D7SFQ6"/>
    <dbReference type="PeptideAtlas" id="D7SFQ6"/>
    <dbReference type="GeneID" id="180356"/>
    <dbReference type="AGR" id="WB:WBGene00001043"/>
    <dbReference type="CTD" id="180356"/>
    <dbReference type="WormBase" id="W07A8.3c">
        <property type="protein sequence ID" value="CE45089"/>
        <property type="gene ID" value="WBGene00001043"/>
        <property type="gene designation" value="dnj-25"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357622_0_0_1"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001043">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFQ6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="439"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="134"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBM41238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W07A8.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D7SFQ6"/>
        </source>
    </evidence>
    <sequence length="441" mass="48456" checksum="27F8AB8D3BEFDEF2" modified="2010-08-10" version="1">MIVNFATRRMPTLNTFQFDRYKLLCVRNDRELDGYQRSYGDVDSEDESPILRSARSKSGTKAAETSSSQGNFFDSLQFEDRQEPHHFREQRDSTLLDHHDDVTHHTADLLDGFTIGGTEKLSPANETPILSAPTPASSDYDSMTSSQNRRNPSPATAIDDLLGLGTETSAPAPAPSTHFNNSSSGANLVDFDLGAPIKPTSSASNLSTASPATSSWSNTDLLGGFSPMKPQTTSTPPNTRNPSASNSKPVSQVNSQADFEAFLSNYPEQRQAAPQNTQNVSQKTQQTRPQNTYKPAFGDAATGSAKVSMDAFSDLLNQGGFKPTQRENQKQSIGNMLKVEQSKNLTPEEIQIRDWTQGKERNIRALLGSLHNVLWEGADRWNQPSMGDLLTPDQIKKHYRKACLVVHPDKLTGSPHLSLAKMAFTELNDAYSKYQNDPAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFQ9</accession>
    <name>D7SFQ9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F53H2.3</name>
        <name evidence="2 4" type="ORF">F53H2.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBM41207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256917.1">
        <property type="nucleotide sequence ID" value="NM_001269988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFQ9"/>
    <dbReference type="GeneID" id="180338"/>
    <dbReference type="AGR" id="WB:WBGene00010006"/>
    <dbReference type="CTD" id="180338"/>
    <dbReference type="WormBase" id="F53H2.3c">
        <property type="protein sequence ID" value="CE45104"/>
        <property type="gene ID" value="WBGene00010006"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031752_0_0_1"/>
    <dbReference type="OrthoDB" id="5855670at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010006">
        <property type="expression patterns" value="Expressed in embryo and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFQ9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBM41207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F53H2.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="D7SFQ9"/>
        </source>
    </evidence>
    <sequence length="395" mass="42132" checksum="33404D21450CF24B" modified="2010-08-10" version="1">MSESSEEGTAIISTALTSSGAPSCATPGISAATTTANGNNNEEYWFYDVATDGYYYEQNGAKGWRRRQPNQAVHKSAGKDSEVAHMNVNGPSKYNQLLAAQAAAAQAAFLQQAFQLQAQQQASQAPQGAHAPPPPQQQQQPTMRYYDANSDGFFYEMASVDGWKRRQPNKPVSASVPAGITRPYSQRPAAQQIPQEVAAPYHPSTAAPTSGASSYGAALARGQFPRNTVKHDEKCAQNAQQQQPRGDSTSSSQCGDTFAELFSSSDPVYIPRPSALNLEQKAVSPSENSTAALFDAVLADFGGFKATSANLNPLLPGISSSQSPMKGESWNSFRSCSLFSPIKPSKRAPLSSNGLQTQASAAAMEDFDDDSTMKMLIQDLDKLWANSPVSGLNQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-09-03" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>D9N129-2</accession>
    <name>WDR20_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of WD repeat-containing protein 20 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">wdr-20</name>
        <name type="ORF">C08B6.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2014" name="J. Biol. Chem." volume="289" first="3444" last="3456">
            <title>The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dahlberg C.L."/>
                <person name="Juo P."/>
            </authorList>
            <dbReference type="PubMed" id="24356955"/>
            <dbReference type="DOI" id="10.1074/jbc.M113.507541"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH USP-46</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>D9N129-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>D9N129-2</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_055505"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q8TBZ3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CBO21933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C08B6.7b"/>
        </source>
    </evidence>
    <sequence length="750" mass="81740" checksum="AF18BA10A15B1831" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G4S6S8</accession>
    <name>G4S6S8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">37S ribosomal protein S25, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C38C3.3</name>
        <name evidence="1" type="ORF">CELE_C38C3.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD67029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255999.1">
        <property type="nucleotide sequence ID" value="NM_001269070.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4S6S8"/>
    <dbReference type="SMR" id="G4S6S8"/>
    <dbReference type="GeneID" id="178642"/>
    <dbReference type="AGR" id="WB:WBGene00016512"/>
    <dbReference type="CTD" id="178642"/>
    <dbReference type="WormBase" id="C38C3.3a">
        <property type="protein sequence ID" value="CE40922"/>
        <property type="gene ID" value="WBGene00016512"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817427at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016512">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G4S6S8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD67029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C38C3.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="G4S6S8"/>
        </source>
    </evidence>
    <sequence length="256" mass="29772" checksum="46A13803222D026D" modified="2012-01-25" version="2">MPFLTTIYRQIPTGKPRVVEKPKKRDVYVTNWDRAAAEQPKALSTWIYQPFDKKKYNNRTASEAFDAYQHRLRLKKLPETKQKFTKTTKRHVTIIEAATEVVQDRCHPQPKSYQKIRIFNHRDDEVKIDNFSARRAPKLRDDDSDELNVDVPAEDDDDVELDDVIVAQNPAFYGTIEAEKCAERVAAHLSMACENMERLQFVSEAVYPQSADHLKKLQEIDDDVKDFNWQMRERRVKASNPAGTATKVAHFIIHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>G4S708</accession>
    <name>G4S708_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guided entry of tail-anchored proteins factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tail-anchored protein insertion receptor WRB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Tryptophan-rich basic protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">wrb-1</name>
        <name evidence="11" type="ORF">CELE_Y50D4A.2</name>
        <name evidence="13" type="ORF">Y50D4A.2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WRB/GET1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD67101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379795.1">
        <property type="nucleotide sequence ID" value="NM_001392472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G4S708"/>
    <dbReference type="SMR" id="G4S708"/>
    <dbReference type="PeptideAtlas" id="G4S708"/>
    <dbReference type="GeneID" id="178617"/>
    <dbReference type="AGR" id="WB:WBGene00021736"/>
    <dbReference type="CTD" id="178617"/>
    <dbReference type="WormBase" id="Y50D4A.2a">
        <property type="protein sequence ID" value="CE30026"/>
        <property type="gene ID" value="WBGene00021736"/>
        <property type="gene designation" value="wrb-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1373299_0_0_1"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021736">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G4S708">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD67101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="Y50D4A.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="G4S708"/>
        </source>
    </evidence>
    <sequence length="192" mass="21325" checksum="6FAC2742D15B897D" modified="2012-01-25" version="2">MDESKPVQISIFNVIAVICSATFAIYSSQIVSTISSTIKSLSKPKPSPKVVALKLKIADLKRELHGISPTAEFARYFKKDREMNKASEELAALEAASPSENSRNLKIDTVVKVFMQFSALFLLRHVSAITAYCIPDTIFWPFNVLVRFPAVFGNDSCPAEFAEVSGFALTFLMIHLLNLALKTFRKSDLKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>I7KSB9</accession>
    <name>I7KSB9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">ets-5</name>
        <name evidence="11" type="ORF">C42D8.4</name>
        <name evidence="9" type="ORF">CELE_C42D8.4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCJ09391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263956.1">
        <property type="nucleotide sequence ID" value="NM_001277027.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I7KSB9"/>
    <dbReference type="SMR" id="I7KSB9"/>
    <dbReference type="GeneID" id="180778"/>
    <dbReference type="KEGG" id="cel:CELE_C42D8.4"/>
    <dbReference type="AGR" id="WB:WBGene00016600"/>
    <dbReference type="CTD" id="180778"/>
    <dbReference type="WormBase" id="C42D8.4b">
        <property type="protein sequence ID" value="CE47699"/>
        <property type="gene ID" value="WBGene00016600"/>
        <property type="gene designation" value="ets-5"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045216_3_0_1"/>
    <dbReference type="OMA" id="VNAHCIA"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="PhylomeDB" id="I7KSB9"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016600">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="I7KSB9">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000392">
        <property type="entry name" value="FEV, ETS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF304">
        <property type="entry name" value="DNA-BINDING PROTEIN D-ETS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ETS" evidence="8">
        <location>
            <begin position="73"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCJ09391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C42D8.4b"/>
        </source>
    </evidence>
    <sequence length="246" mass="26839" checksum="4A37DA196E39F7E3" modified="2012-10-03" version="1">MYPATLNNYNNVCQTTSSTQWDTPLANNPDTTRLADGCMQYASALSRIPSSNSTSASKGPMAIALSATGTGQIQLWQFLLELLADAVNAHCIAWEGSNGEFKLVDPDEVARKWGERKSKPNMNYDKLSRALRYYYDKNIMTKVQGKRYAYKFDFQGLAQACQSAILTNGGNPNGDLSSTVHSLSPYTNQVLPIGVTSRLSTSMSSYHSILSSTSSTSSNQIIPPSTATYWSTPQSSLTYTGMPSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-04-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>L8EC32</accession>
    <name>L8EC32_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">dnc-1</name>
        <name evidence="17" type="ORF">CELE_ZK593.5</name>
        <name evidence="19" type="ORF">ZK593.5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCQ25671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263782.1">
        <property type="nucleotide sequence ID" value="NM_001276853.3"/>
    </dbReference>
    <dbReference type="SMR" id="L8EC32"/>
    <dbReference type="GeneID" id="177987"/>
    <dbReference type="AGR" id="WB:WBGene00001017"/>
    <dbReference type="CTD" id="177987"/>
    <dbReference type="WormBase" id="ZK593.5d">
        <property type="protein sequence ID" value="CE48197"/>
        <property type="gene ID" value="WBGene00001017"/>
        <property type="gene designation" value="dnc-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001017">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="L8EC32">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="16">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="73"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="975"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1074"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1161"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCQ25671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="ZK593.5d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="L8EC32"/>
        </source>
    </evidence>
    <sequence length="1323" mass="148203" checksum="78F2BCE84DF7CFB7" modified="2013-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-04-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>L8EC33</accession>
    <name>L8EC33_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">parg-1</name>
        <name evidence="11" type="synonym">pme-3</name>
        <name evidence="9" type="ORF">CELE_F20C5.1</name>
        <name evidence="11" type="ORF">F20C5.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCQ25676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263754.1">
        <property type="nucleotide sequence ID" value="NM_001276825.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L8EC33"/>
    <dbReference type="SMR" id="L8EC33"/>
    <dbReference type="PeptideAtlas" id="L8EC33"/>
    <dbReference type="GeneID" id="177683"/>
    <dbReference type="AGR" id="WB:WBGene00004051"/>
    <dbReference type="CTD" id="177683"/>
    <dbReference type="WormBase" id="F20C5.1f">
        <property type="protein sequence ID" value="CE48108"/>
        <property type="gene ID" value="WBGene00004051"/>
        <property type="gene designation" value="parg-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937899at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004051">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="L8EC33">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF15">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="7">
        <location>
            <begin position="507"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCQ25676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F20C5.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="L8EC33"/>
        </source>
    </evidence>
    <sequence length="782" mass="89360" checksum="2C79CFB7AAC1ECEC" modified="2013-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-04-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>L8EC34</accession>
    <name>L8EC34_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_ZK688.5</name>
        <name evidence="3 5" type="ORF">ZK688.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCQ25681.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="L8EC34"/>
    <dbReference type="PeptideAtlas" id="L8EC34"/>
    <dbReference type="AGR" id="WB:WBGene00022800"/>
    <dbReference type="WormBase" id="ZK688.5d">
        <property type="protein sequence ID" value="CE54085"/>
        <property type="gene ID" value="WBGene00022800"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1885901at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022800">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="L8EC34">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000470">
        <property type="entry name" value="Protein CBG12265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ25681.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="ZK688.5d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="L8EC34"/>
        </source>
    </evidence>
    <sequence length="1614" mass="181805" checksum="6D9F1892B30E34E3" modified="2020-06-17" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-04-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>L8EC35</accession>
    <name>L8EC35_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_R11D1.1</name>
        <name evidence="5 7" type="ORF">R11D1.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCQ25686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001263874.1">
        <property type="nucleotide sequence ID" value="NM_001276945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="L8EC35"/>
    <dbReference type="GeneID" id="179738"/>
    <dbReference type="KEGG" id="cel:CELE_R11D1.1"/>
    <dbReference type="AGR" id="WB:WBGene00011242"/>
    <dbReference type="CTD" id="179738"/>
    <dbReference type="WormBase" id="R11D1.1d">
        <property type="protein sequence ID" value="CE21120"/>
        <property type="gene ID" value="WBGene00011242"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025008_0_0_1"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011242">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="L8EC35">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF43">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
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            <begin position="461"/>
            <end position="502"/>
        </location>
    </feature>
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        <location>
            <begin position="547"/>
            <end position="619"/>
        </location>
    </feature>
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        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
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        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
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        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCQ25686.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="R11D1.1d"/>
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    </evidence>
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        </source>
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</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PeptideAtlas" id="L8EC36"/>
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    <dbReference type="AGR" id="WB:WBGene00013481"/>
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        <property type="protein sequence ID" value="CE48185"/>
        <property type="gene ID" value="WBGene00013481"/>
    </dbReference>
    <dbReference type="OrthoDB" id="152433at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013481">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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        <source>
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    </evidence>
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            <dbReference type="PeptideAtlas" id="L8EC36"/>
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</entry>
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        </lineage>
    </organism>
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            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="WBGene00009765"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="184"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
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        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ25696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F46B3.14d"/>
        </source>
    </evidence>
    <sequence length="184" mass="19168" checksum="A98BE745B027004B" modified="2013-04-03" version="1">MKYILCLLLAGGISARVAPIESIVGPGAPCIGEECGDNLSNPCSLIKCSNGSHCVPRGTTGRCVLDSNPCASIKCGRGYHCAVENGQGGCVPNVPSEVDLCSLVKCALGGHCENGNCVPDVPSEYDLCSQVKCAIGSRCKNGTASQSIHASLFSAPLDRNVYSATNLQPVFQMWPSLLVLHKSI</sequence>
</entry>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="WBGene00010686"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="L8EC39">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46073:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="77"/>
        </location>
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            <begin position="95"/>
            <end position="249"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ25706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K08F9.3c"/>
        </source>
    </evidence>
    <sequence length="258" mass="29479" checksum="2F7FFD17B2A9085C" modified="2013-04-03" version="1">MWYLFNPYDNTGRASPAYLPVPNHAVPFYDPTVIGNKTRRSYFSIQSCFVNFCSKIIMGCFVILFLFSLNFGIYSLVSHSDHAQSKTPDQCDKQLIGYYNGIEGRNILENQFHNLTHAVFTSEFVNENGSFENSHKEQEFLECRKKLGESNSTAKIMIAMGFNKGSCKIDCITSFIEKYQVDGVELHWNHNEHFLSQLETTRNLKNRLKKISNSKLLGVSASSNWSRVTELDQVLEVADFVNIELHDNLRSDNLHAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-07-01" modified="2025-10-08" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>O01731</accession>
    <name>O01731_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C09D4.4</name>
        <name evidence="3" type="ORF">CELE_C09D4.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
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    <dbReference type="WormBase" id="C09D4.4a">
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        <property type="gene ID" value="WBGene00015635"/>
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    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
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    <dbReference type="Bgee" id="WBGene00015635">
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000653">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
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    <dbReference type="PANTHER" id="PTHR12482:SF5">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="622"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD63889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C09D4.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="O01731"/>
        </source>
    </evidence>
    <sequence length="913" mass="103421" checksum="B08D5FB40A3C83AA" modified="2003-10-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1997-07-01" modified="2025-10-08" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>O01808</accession>
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        <submittedName>
            <fullName evidence="9">UBR-type domain-containing protein</fullName>
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        <name evidence="11" type="ORF">C44E4.1</name>
        <name evidence="9" type="ORF">CELE_C44E4.1</name>
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    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">Bristol N2</strain>
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        <text evidence="1 6">Belongs to the UBR4 family.</text>
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        <property type="entry name" value="T30950"/>
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    <dbReference type="PeptideAtlas" id="O01808"/>
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        <property type="component" value="Chromosome I"/>
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    <dbReference type="Bgee" id="WBGene00016650">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="O01808">
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    </dbReference>
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    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
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    <dbReference type="PANTHER" id="PTHR21725">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02916">
        <property type="entry name" value="DNA_PPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13764">
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    <dbReference type="Pfam" id="PF24079">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="8">
        <location>
            <begin position="1214"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="5">
        <location>
            <begin position="1214"/>
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    <feature type="region of interest" description="UBR4 E3 catalytic module" evidence="6">
        <location>
            <begin position="3800"/>
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    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1323"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2124"/>
            <end position="2151"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009970"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01388"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD67301.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C44E4.1a"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="O01808"/>
        </source>
    </evidence>
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</entry>
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    <reference key="1">
        <citation type="journal article" date="1997" name="Neuron" volume="18" first="613" last="622">
            <title>aex-3 encodes a novel regulator of presynaptic activity in C. elegans.</title>
            <authorList>
                <person name="Iwasaki K."/>
                <person name="Staunton J."/>
                <person name="Saifee O."/>
                <person name="Nonet M."/>
                <person name="Thomas J.H."/>
            </authorList>
            <dbReference type="PubMed" id="9136770"/>
            <dbReference type="DOI" id="10.1016/S0896-6273(00)80302-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="EMBO J." volume="19" first="4806" last="4816">
            <title>The rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission.</title>
            <authorList>
                <person name="Iwasaki K."/>
                <person name="Toyonaga R."/>
            </authorList>
            <dbReference type="PubMed" id="10970871"/>
            <dbReference type="DOI" id="10.1093/emboj/19.17.4806"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CAB-1</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="16350" last="16355">
            <title>Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mahoney T.R."/>
                <person name="Luo S."/>
                <person name="Round E.K."/>
                <person name="Brauner M."/>
                <person name="Gottschalk A."/>
                <person name="Thomas J.H."/>
                <person name="Nonet M.L."/>
            </authorList>
            <dbReference type="PubMed" id="18852466"/>
            <dbReference type="DOI" id="10.1073/pnas.0803617105"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2010" name="Cell" volume="143" first="430" last="441">
            <title>Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis.</title>
            <authorList>
                <person name="Bai J."/>
                <person name="Hu Z."/>
                <person name="Dittman J.S."/>
                <person name="Pym E.C."/>
                <person name="Kaplan J.M."/>
            </authorList>
            <dbReference type="PubMed" id="21029864"/>
            <dbReference type="DOI" id="10.1016/j.cell.2010.09.024"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="PLoS ONE" volume="10" first="E0124515" last="E0124515">
            <title>Aberrant fat metabolism in Caenorhabditis elegans mutants with defects in the defecation motor program.</title>
            <authorList>
                <person name="Sheng M."/>
                <person name="Hosseinzadeh A."/>
                <person name="Muralidharan S.V."/>
                <person name="Gaur R."/>
                <person name="Selstam E."/>
                <person name="Tuck S."/>
            </authorList>
            <dbReference type="PubMed" id="25849533"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0124515"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2016" name="Genetics" volume="203" first="1235" last="1247">
            <title>Pioneer Axon Navigation Is Controlled by AEX-3, a Guanine Nucleotide Exchange Factor for RAB-3 in Caenorhabditis elegans.</title>
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                <person name="Bhat J.M."/>
                <person name="Hutter H."/>
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            <dbReference type="PubMed" id="27116976"/>
            <dbReference type="DOI" id="10.1534/genetics.115.186064"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
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    <name>TOM22_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Mitochondrial import receptor subunit TOM22 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tomm-22</name>
        <name evidence="3" type="ORF">W10D9.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E14507" last="E14507">
            <title>Mitochondrial function is required for secretion of DAF-28/insulin in C. elegans.</title>
            <authorList>
                <person name="Billing O."/>
                <person name="Kao G."/>
                <person name="Naredi P."/>
            </authorList>
            <dbReference type="PubMed" id="21264209"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0014507"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O17287-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>O17287-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_058486"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001368584.1">
        <property type="nucleotide sequence ID" value="NM_001381316.1"/>
    </dbReference>
    <dbReference type="WormBase" id="W10D9.5b">
        <property type="protein sequence ID" value="CE51123"/>
        <property type="gene ID" value="WBGene00021133"/>
        <property type="gene designation" value="tomm-22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="W10D9.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="W10D9.5b"/>
        </source>
    </evidence>
    <sequence length="15" mass="1500" checksum="C882397A03E4F364" modified="1998-01-01" version="1">MLLGPSAAIQQAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="172" xmlns="https://uniprot.org/uniprot">
    <accession>O17395</accession>
    <name>O17395_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Large neutral amino acids transporter small subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">aat-3</name>
        <name evidence="10" type="ORF">CELE_F52H2.2</name>
        <name evidence="12" type="ORF">F52H2.2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD71657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T32479">
        <property type="entry name" value="T32479"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508461.1">
        <property type="nucleotide sequence ID" value="NM_076060.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O17395"/>
    <dbReference type="SMR" id="O17395"/>
    <dbReference type="PeptideAtlas" id="O17395"/>
    <dbReference type="GeneID" id="180557"/>
    <dbReference type="UCSC" id="F52H2.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000004"/>
    <dbReference type="CTD" id="180557"/>
    <dbReference type="WormBase" id="F52H2.2a">
        <property type="protein sequence ID" value="CE28440"/>
        <property type="gene ID" value="WBGene00000004"/>
        <property type="gene designation" value="aat-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_3_0_1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="PhylomeDB" id="O17395"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000004">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O17395">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990184">
        <property type="term" value="C:amino acid transport complex"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902475">
        <property type="term" value="P:L-alpha-amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF421">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD71657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F52H2.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="O17395"/>
        </source>
    </evidence>
    <sequence length="493" mass="53889" checksum="4C29D81C334F324C" modified="2001-10-01" version="2">MGKQEQSEPLNQEPSNEHHDEEVGDKGLEKTMTLFNGVSIIVGCIIGSGIFISPTGIQAQAGSVGLSLIVWVLSGLFAGIGAFCYAELGTLIRKSGGDYAYIMEAFGPFLAFLRLWIESIVVRPCTATIVALTFAIYMLKPFYPDCDSPPLSTELIAALLLVLLTAVNCISVKWASKVQDFFFVTKTAALVLIIFTGLWNMVSGKPEAFDSFENIFENTAKDLETASLAFYSGLFAYQGWNYLNFIVEELQNPKRNLPLSIAISCSLCTIIYTLTNVALYTSITPDEMLASPAVAVLFAEKNYGWFAFCMPIFVACSTIGSANGVILTSSRLFYCGAREGQMPNVLTMVNKTTKTPIPAVILTGLLSLLYLLLSNNIYSLINYIQVSYWIAIGGAILALFYFRKTMPDAPRAVKAPIVFPIIFFIGCVLLVLVPVLGNPKDTAIGILIMLSGVPVYLIFIAWKGKPKCIDSLTDSVTIFTQKLFMVVDANKEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-06-05" modified="2026-01-28" version="187" xmlns="https://uniprot.org/uniprot">
    <accession>O45734-2</accession>
    <name>CPL1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Cathepsin L-like</fullName>
            <ecNumber evidence="1">3.4.22.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">cpl-1</name>
        <name evidence="5" type="ORF">T03E6.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2002" name="J. Biol. Chem." volume="277" first="3477" last="3486">
            <title>Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hashmi S."/>
                <person name="Britton C."/>
                <person name="Liu J."/>
                <person name="Guiliano D.B."/>
                <person name="Oksov Y."/>
                <person name="Lustigman S."/>
            </authorList>
            <dbReference type="PubMed" id="11707440"/>
            <dbReference type="DOI" id="10.1074/jbc.M106117200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2004" name="J. Cell Sci." volume="117" first="5133" last="5143">
            <title>Cathepsin L protease (CPL-1) is essential for yolk processing during embryogenesis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Britton C."/>
                <person name="Murray L."/>
            </authorList>
            <dbReference type="PubMed" id="15456850"/>
            <dbReference type="DOI" id="10.1242/jcs.01387"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 120-VAL--LYS-268</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2006" name="J. Biol. Chem." volume="281" first="28415" last="28429">
            <title>The Caenorhabditis elegans CPI-2a cystatin-like inhibitor has an essential regulatory role during oogenesis and fertilization.</title>
            <authorList>
                <person name="Hashmi S."/>
                <person name="Zhang J."/>
                <person name="Oksov Y."/>
                <person name="Ji Q."/>
                <person name="Lustigman S."/>
            </authorList>
            <dbReference type="PubMed" id="16857685"/>
            <dbReference type="DOI" id="10.1074/jbc.M600254200"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E40145" last="E40145">
            <title>A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.</title>
            <authorList>
                <person name="Miedel M.T."/>
                <person name="Graf N.J."/>
                <person name="Stephen K.E."/>
                <person name="Long O.S."/>
                <person name="Pak S.C."/>
                <person name="Perlmutter D.H."/>
                <person name="Silverman G.A."/>
                <person name="Luke C.J."/>
            </authorList>
            <dbReference type="PubMed" id="22768338"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0040145"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF TRP-32 AND TYR-35</scope>
    </reference>
    <reference evidence="3" key="6">
        <citation type="journal article" date="2014" name="Mol. Biol. Cell" volume="25" first="2071" last="2083">
            <title>The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Xu M."/>
                <person name="Liu Y."/>
                <person name="Zhao L."/>
                <person name="Gan Q."/>
                <person name="Wang X."/>
                <person name="Yang C."/>
            </authorList>
            <dbReference type="PubMed" id="24829385"/>
            <dbReference type="DOI" id="10.1091/mbc.E14-01-0015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 1-MET--TYR-51; GLY-230 AND 120-VAL--LYS-268</scope>
    </reference>
    <reference evidence="3" key="7">
        <citation type="journal article" date="2016" name="Genetics" volume="202" first="1071" last="1083">
            <title>Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos.</title>
            <authorList>
                <person name="Schmoekel V."/>
                <person name="Memar N."/>
                <person name="Wiekenberg A."/>
                <person name="Trotzmueller M."/>
                <person name="Schnabel R."/>
                <person name="Doering F."/>
            </authorList>
            <dbReference type="PubMed" id="26773047"/>
            <dbReference type="DOI" id="10.1534/genetics.115.179127"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ALA-146 AND ARG-320</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O45734-2</id>
            <name evidence="6">b</name>
            <sequence type="described" ref="VSP_060182"/>
        </isoform>
        <isoform>
            <id>O45734-1</id>
            <name evidence="5">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.22.15" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001256719.1">
        <property type="nucleotide sequence ID" value="NM_001269790.3"/>
    </dbReference>
    <dbReference type="WormBase" id="T03E6.7b">
        <property type="protein sequence ID" value="CE47424"/>
        <property type="gene ID" value="WBGene00000776"/>
        <property type="gene designation" value="cpl-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P06797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="11707440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T03E6.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T03E6.7b"/>
        </source>
    </evidence>
    <sequence length="198" mass="21838" checksum="A202649FDBF10BA0" modified="1998-06-01" version="1" precursor="true">MCGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>P34566-2</accession>
    <name>YNV3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Uncharacterized protein T16H12.3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T16H12.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34566-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_060967 VSP_060965"/>
        </isoform>
        <isoform>
            <id>P34566-3</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_060966"/>
        </isoform>
        <isoform>
            <id>P34566-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367081.1">
        <property type="nucleotide sequence ID" value="NM_001379880.2"/>
    </dbReference>
    <dbReference type="WormBase" id="T16H12.3b">
        <property type="protein sequence ID" value="CE54154"/>
        <property type="gene ID" value="WBGene00011813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="T16H12.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T16H12.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T16H12.3c"/>
        </source>
    </evidence>
    <sequence length="326" mass="37651" checksum="5E8593915EFA72D3" modified="2021-04-07" version="3">MSDTTYFTDAWQPKEVLDPETETNANESIIQMVFYHKLACIYHIIMSNYTWKQADIQTLISFYETLGEEINPKVQKVQQNSEANSFSEKAKKFGLLDLPIYSKCVDSSQLIAESASRVYHDAKEYMNNGSATEAELYRFVSSILKEVLEPIFNPKEIRNVLKGLITSLVDSRSRDEEIGSDIEKNVKYEVVRFLPESPPNFPGFNDNVSRSITNFIGYFALHTIRHHCYVNFGVDGELKFYQRNMYKKAFDDLRVNKAKPTVSVKPEASLKREPKAETPTLTRVKPEIRNDSDEDFCCQEIQNSANIGKQCQRWKRIERFPGKIYA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>P34566-3</accession>
    <name>YNV3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Uncharacterized protein T16H12.3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T16H12.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34566-3</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_060966"/>
        </isoform>
        <isoform>
            <id>P34566-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34566-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_060967 VSP_060965"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001370945.1">
        <property type="nucleotide sequence ID" value="NM_001382974.2"/>
    </dbReference>
    <dbReference type="WormBase" id="T16H12.3c">
        <property type="protein sequence ID" value="CE50218"/>
        <property type="gene ID" value="WBGene00011813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="T16H12.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T16H12.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T16H12.3c"/>
        </source>
    </evidence>
    <sequence length="381" mass="44146" checksum="AC59D1339010461E" modified="2021-04-07" version="3">MSDTTYFTDAWQPKEVLDPETETNANESIIQMVFYHKLACIYHIIMSNYTWKQADIQTLISFYETLGEEINPKVQKVQQNSEANSFSEKAKKFGLLDLPIYSKCVDSSQLIAESASRVYHDAKEYMNNGSATEAELYRFVSSILKEVLEPIFNPKEIRNVLKGLITSLVDSRSRDEEIGSDIEKNVKYEVVRFLPESPPNFPGFNDNVSRSITNFIGYFALHTIRHHCYVNFGVDGELKFYQRNMYKKAFDDLRVNKAKPTVSVKPEASLKREPKAETPTLTRVKPEIRNDSDEDFCEIIEPAVKKSKTRQTSESNAKGGKELKDFPEKYMLEDLDKDDLPMNFKTKFRKLVEQNQMLRDEINDYKELIQLKIAEKKQRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-09-05" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q0PDK2</accession>
    <name>Q0PDK2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">unc-49</name>
        <name evidence="3" type="ORF">CELE_T21C12.1</name>
        <name evidence="5" type="ORF">T21C12.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAL22700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001076648.1">
        <property type="nucleotide sequence ID" value="NM_001083179.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q0PDK2"/>
    <dbReference type="SMR" id="Q0PDK2"/>
    <dbReference type="GeneID" id="176472"/>
    <dbReference type="UCSC" id="T21C12.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006784"/>
    <dbReference type="CTD" id="176472"/>
    <dbReference type="WormBase" id="T21C12.1i">
        <property type="protein sequence ID" value="CE40338"/>
        <property type="gene ID" value="WBGene00006784"/>
        <property type="gene designation" value="unc-49"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010920_3_1_1"/>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006784">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q0PDK2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043058">
        <property type="term" value="P:regulation of backward locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAL22700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T21C12.1i"/>
        </source>
    </evidence>
    <sequence length="157" mass="17952" checksum="CED83F1E5E2CA7F2" modified="2006-09-05" version="1">MTVLTETHLMTGTNRRLPPVAYVKAVDVFLGFCYLLVILALIEYACVAYSKKKNEDRRRREKKTEHKPAPPTPDILHDVRLAECTCNAAPTSIIAVIKQSNRFCVSHSHIDIVSRAAFPLVFILFNTLFWLILLYKSKRLPYISEHEGDRCDAPDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-09-05" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q0PDL1</accession>
    <name>Q0PDL1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear migration protein unc-83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">unc-83</name>
        <name evidence="3" type="ORF">CELE_W01A11.3</name>
        <name evidence="5" type="ORF">W01A11.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD74263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380084.1">
        <property type="nucleotide sequence ID" value="NM_001392532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q0PDL1"/>
    <dbReference type="SMR" id="Q0PDL1"/>
    <dbReference type="GeneID" id="179033"/>
    <dbReference type="UCSC" id="W01A11.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006815"/>
    <dbReference type="CTD" id="179033"/>
    <dbReference type="WormBase" id="W01A11.3b">
        <property type="protein sequence ID" value="CE40370"/>
        <property type="gene ID" value="WBGene00006815"/>
        <property type="gene designation" value="unc-83"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5805552at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006815">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q0PDL1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="project" value="WormBase"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
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            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD74263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W01A11.3b"/>
        </source>
    </evidence>
    <sequence length="975" mass="110397" checksum="3BDCED3F5A0CF462" modified="2006-09-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q18411-2</accession>
    <name>NTP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Nucleoside-triphosphatase ntp-1</fullName>
            <ecNumber>3.6.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ntp-1</name>
        <name evidence="2" type="ORF">C33H5.14</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="27390" last="27398">
            <title>ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans.</title>
            <authorList>
                <person name="Uccelletti D."/>
                <person name="O'Callaghan C."/>
                <person name="Berninsone P."/>
                <person name="Zemtseva I."/>
                <person name="Abeijon C."/>
                <person name="Hirschberg C.B."/>
            </authorList>
            <dbReference type="PubMed" id="15102851"/>
            <dbReference type="DOI" id="10.1074/jbc.M402624200"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q18411-1</id>
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            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q18411-2</id>
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        </isoform>
    </comment>
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    </dbReference>
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        <property type="gene ID" value="WBGene00016380"/>
        <property type="gene designation" value="ntp-1"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="C33H5.14a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C33H5.14b"/>
        </source>
    </evidence>
    <sequence length="509" mass="57067" checksum="5AE9DFE3C2E615F4" modified="2016-04-13" version="2">MRTYNVYGFLLTCTCLLLILTIIPMSGGSSERVQRSVRSVVETKNNIKYGVICDAGSSGTRLFVYTLKPLSGGLTNIDTLIHESEPVVKKVTPGLSSFGDKPEQVVEYLTPLLRFAEEHIPYEQLGETDLLIFATAGMRLLPEAQKDAIIKNLQNGLKSVTALRVSDSNIRIIDGAWEGIYSWIAVNYILGRFDKENDSKVGMIDMGGASVQIAFEIANEKESYNGGNVYEINLGSIETNEDYKYKIYSTTFLGYGANEGLKKYENSLVKSGNSNDSCSPRGLNRLIGEFTVNGTGEWDVCLAQVSSLIGDKAQPSCPNPTCFLRNVIAPSVNLSTVQLYGFSEYWYTTSNFGSGGEYHYQKFTDEVRKYCQKDWNDIQDGFKRNEFPNADIERLGTNCFKAAWVTSVLHDGFNVDKTKHLFQSVLKIAGEEMQWALGAMLYHSKDLKFNLLEQLEVAQSTQQISNFFSFFVILIIVLAVALYRQLQSESTYKKYNFLRTDSKPDFLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="186" xmlns="https://uniprot.org/uniprot">
    <accession>Q18930</accession>
    <name>Q18930_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">A kinase anchor protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">aka-1</name>
        <name evidence="7" type="synonym">kap-1</name>
        <name evidence="8" type="ORF">CELE_D1022.7</name>
        <name evidence="10" type="ORF">D1022.7</name>
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    <organism evidence="7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="14633" last="14643">
            <title>Molecular characterization of an anchor protein (AKAPCE) that binds the RI subunit (RCE) of type I protein kinase A from Caenorhabditis elegans.</title>
            <authorList>
                <person name="Angelo R."/>
                <person name="Rubin C.S."/>
            </authorList>
            <dbReference type="PubMed" id="9603981"/>
            <dbReference type="DOI" id="10.1074/jbc.273.23.14633"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF045926">
        <property type="protein sequence ID" value="AAC24507.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD68339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T42514">
        <property type="entry name" value="T42514"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022045.1">
        <property type="nucleotide sequence ID" value="NM_001026874.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q18930"/>
    <dbReference type="SMR" id="Q18930"/>
    <dbReference type="GeneID" id="174216"/>
    <dbReference type="KEGG" id="cel:CELE_D1022.7"/>
    <dbReference type="UCSC" id="D1022.7a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000101"/>
    <dbReference type="CTD" id="174216"/>
    <dbReference type="WormBase" id="D1022.7a">
        <property type="protein sequence ID" value="CE02581"/>
        <property type="gene ID" value="WBGene00000101"/>
        <property type="gene designation" value="aka-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006554_0_0_1"/>
    <dbReference type="OrthoDB" id="5872154at2759"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000101">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q18930">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0000250"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022557">
        <property type="entry name" value="SARA-like_C"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46319">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46319:SF3">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11979">
        <property type="entry name" value="SARA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01421">
        <property type="entry name" value="DUF3480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="538"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC24507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD68339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="D1022.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q18930"/>
        </source>
    </evidence>
    <sequence length="1280" mass="143532" checksum="11FC304D7374EFB6" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="182" xmlns="https://uniprot.org/uniprot">
    <accession>Q18937</accession>
    <name>Q18937_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">cfim-2</name>
        <name evidence="6" type="ORF">CELE_D1046.1</name>
        <name evidence="8" type="ORF">D1046.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA92294.2"/>
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        <property type="entry name" value="T20293"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="DIP" id="DIP-26579N"/>
    <dbReference type="IntAct" id="Q18937">
        <property type="interactions" value="8"/>
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    <dbReference type="UCSC" id="D1046.1.1">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00008362"/>
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    <dbReference type="WormBase" id="D1046.1a">
        <property type="protein sequence ID" value="CE03094"/>
        <property type="gene ID" value="WBGene00008362"/>
        <property type="gene designation" value="cfim-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025289_1_0_1"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="PhylomeDB" id="Q18937"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008362">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25524">
        <property type="entry name" value="RSLD_CPSF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSF6/7 RSLD" evidence="5">
        <location>
            <begin position="374"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA92294.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="D1046.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q18937"/>
        </source>
    </evidence>
    <sequence length="489" mass="53662" checksum="273BD586EAAF3E66" modified="2003-03-01" version="3">MAELDEAALLGDGNEQHDGPIDENALLDGKELKEEDIDDLYDEAIAPTNSTESAKPVSPTITTVTAPTAGIGAKPATSSEGRKYCCYVGNLLWYTTDADLLKALQSTGLARSQFADMKFFENRTNGQSKGYALLVLNSDAAVKQTMEILPTKTIHGQSPTVLSYNKTNQAKLEDAQAKNQTRPDVKKKGFEEGCVNMGTIRIGAGGQTGRTGTSVSGRSGPPPLMMQQVRPTPLMSQPTSLPSNLNQAPQMRLQINGQQVPLMNRAPVPQQTMLGNGPLGGMNQQIQQQPQMMMGQQVRPMMQTSMGIQPMMGMNAPPPMNNQFQNRPPQLGSMGVQPLMQMNTAMRPPINGLPPVHVNPQMFPGLQGTVLSDAEFEDVMTRNQTVSSSAIARAITDASVGDIKGASETILTAIQLIKNSRIGHDERCRQLVYGLEHTLKGLESKGYSSRSKSHRDRSRSRERDRKRRRRSRTRSRSYSRSPSPRRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="166" xmlns="https://uniprot.org/uniprot">
    <accession>Q22188</accession>
    <name>Q22188_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">npr-2</name>
        <name evidence="12" type="ORF">CELE_T05A1.1</name>
        <name evidence="14" type="ORF">T05A1.1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA92481.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T24487">
        <property type="entry name" value="T24487"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359554.1">
        <property type="nucleotide sequence ID" value="NM_001372906.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q22188"/>
    <dbReference type="SMR" id="Q22188"/>
    <dbReference type="GeneID" id="177790"/>
    <dbReference type="KEGG" id="cel:CELE_T05A1.1"/>
    <dbReference type="UCSC" id="T05A1.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003808"/>
    <dbReference type="CTD" id="177790"/>
    <dbReference type="WormBase" id="T05A1.1b">
        <property type="protein sequence ID" value="CE32925"/>
        <property type="gene ID" value="WBGene00003808"/>
        <property type="gene designation" value="npr-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_6_1_1"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003808">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q22188">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF9">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="43"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAA92481.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T05A1.1b"/>
        </source>
    </evidence>
    <sequence length="387" mass="44128" checksum="195C02A8A65772FE" modified="2003-03-01" version="2">MINETEETCDRYIDKHPDMTNEPTVLVTFSLLYLHIFLLGILGNSAVLYLTMKHRQLQTVQNIFILNLCASNVLMCLTSLPITFITNVYKQWFFSSPVCKLIPLVQGASIFVSTFSLSAIALDRYNLVVRPHKQKLSSRSAMMIALLIWVISVVVCMPYGWYMDVEKLNGLCGEYCSEHWPLAEVRKGYTFLVLITQFLFPFATMAFCYYNIFSRLRQRVETKLKKLSERSQLLENSTTCGTTNHIVSINAEAVQNGLENKQRLAVLAQQRRTTTILSCMVLLFAFTWLPHNVVTLMIEYDGFFFHSDETSATSTDHTYIVSMTAHLISMLTNVTNPFLYAWLNPMFKEMLIKTLRGGSKSPKPADIKQTSFIRMPNSGAPSQSSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q22198</accession>
    <name>Q22198_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cki-2</name>
        <name evidence="8" type="ORF">CELE_T05A6.2</name>
        <name evidence="10" type="ORF">T05A6.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDI family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAA90670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T24499">
        <property type="entry name" value="T24499"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_495642.3">
        <property type="nucleotide sequence ID" value="NM_063241.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q22198"/>
    <dbReference type="IntAct" id="Q22198">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="174261"/>
    <dbReference type="UCSC" id="T05A6.2a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000517"/>
    <dbReference type="CTD" id="174261"/>
    <dbReference type="WormBase" id="T05A6.2a">
        <property type="protein sequence ID" value="CE18928"/>
        <property type="gene ID" value="WBGene00000517"/>
        <property type="gene designation" value="cki-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6373236at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000517">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q22198">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902806">
        <property type="term" value="P:regulation of cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265:SF45">
        <property type="entry name" value="DACAPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 8" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="7">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA90670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="T05A6.2a"/>
        </source>
    </evidence>
    <sequence length="258" mass="28523" checksum="06A1AF2400BDE4D6" modified="1999-05-01" version="2">MAATTAGDGKRKAARCLFGKPDPEEVSRQLNSSLEEMYKKDSRKFNFDFSGGVPIVGSRGDYEFESISASEVPSFYREKIVRPRKIIARRNSTPVSDTVEMPSESPPVVESNETPLLIASTSTEVTVYEKPVTRSSAAKQSIEQQETYNLKQTKLTNYMPVRKRRSETCLVTAAVSMSRSVSIDSSMESCKEKRGSKIVHNNKGAPKRPLRFVASNVPKSAQSSTSDTVLVSSPRSPPAKKMTTSTRRSRRPIEAGDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q22544-3</accession>
    <name>TSCT1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Protein tsct-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tsct-1</name>
        <name evidence="2" type="synonym">txt-21</name>
        <name evidence="2" type="ORF">T18D3.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q22544-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_061797"/>
        </isoform>
        <isoform>
            <id>Q22544-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q22544-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_061798"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001366745.1">
        <property type="nucleotide sequence ID" value="NM_001381119.1"/>
    </dbReference>
    <dbReference type="WormBase" id="T18D3.7c">
        <property type="protein sequence ID" value="CE43264"/>
        <property type="gene ID" value="WBGene00011824"/>
        <property type="gene designation" value="tsct-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T18D3.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T18D3.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T18D3.7c"/>
        </source>
    </evidence>
    <sequence length="131" mass="14042" checksum="53C8C14BDFB6421C" modified="2023-02-22" version="3">MDPETAVVTAGNTGSTASEVGTDFALTNDMTSSPSSVALLSGDPTKMEDSAKLATATSNTVVAIDNKIVQAMDLVKTHLTFAVREEVETLRTTITDLEARLNALREENRLLRENVSPEVLAFITANKQLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q58AA4</accession>
    <name>Q58AA4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CABIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rde-2</name>
        <name evidence="2" type="ORF">CELE_F21C3.4</name>
        <name evidence="4" type="ORF">F21C3.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAI70415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021399.1">
        <property type="nucleotide sequence ID" value="NM_001026228.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q58AA4"/>
    <dbReference type="SMR" id="Q58AA4"/>
    <dbReference type="GeneID" id="172473"/>
    <dbReference type="UCSC" id="F21C3.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004324"/>
    <dbReference type="CTD" id="172473"/>
    <dbReference type="WormBase" id="F21C3.4b">
        <property type="protein sequence ID" value="CE38174"/>
        <property type="gene ID" value="WBGene00004324"/>
        <property type="gene designation" value="rde-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_471925_0_0_1"/>
    <dbReference type="OrthoDB" id="5826127at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004324">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q58AA4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016441">
        <property type="term" value="P:post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAI70415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F21C3.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q58AA4"/>
        </source>
    </evidence>
    <sequence length="570" mass="64958" checksum="F773B047BBE28A1C" modified="2005-04-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q58AA5</accession>
    <name>Q58AA5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rga-1</name>
        <name evidence="3" type="ORF">CELE_W02B12.8</name>
        <name evidence="5" type="ORF">W02B12.8</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAI70416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001022391.1">
        <property type="nucleotide sequence ID" value="NM_001027220.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q58AA5"/>
    <dbReference type="SMR" id="Q58AA5"/>
    <dbReference type="PeptideAtlas" id="Q58AA5"/>
    <dbReference type="GeneID" id="174751"/>
    <dbReference type="UCSC" id="W02B12.8a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012203"/>
    <dbReference type="CTD" id="174751"/>
    <dbReference type="WormBase" id="W02B12.8b">
        <property type="protein sequence ID" value="CE38231"/>
        <property type="gene ID" value="WBGene00012203"/>
        <property type="gene designation" value="rga-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015883_3_0_1"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012203">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q58AA5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000108">
        <property type="entry name" value="Rho GTPase Activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="50"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAI70416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W02B12.8b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q58AA5"/>
        </source>
    </evidence>
    <sequence length="245" mass="27661" checksum="11AFEDEF9D52A4BB" modified="2005-04-26" version="1">MCIDELENALSVARLNLPSPIRDHDKSFSTQSNRPETPPAQPLPTQQFGVPLEFILSHCGGNIPPIVDQLIEYLEAHALTMEGVFRKSANIGSIKRLQDRINKGEKIDFENDPEYKDNEYVASLHASVLLKTFFRSLGEPLTTNRLYPKLAALSEVSKTEKSAAVKEFVKLLPRENYILLKTVIKFLTRVAENSKVNLMTANNLSVVFGPNLTWPTDQEVPISQLNNLNNFCYKLIVDYDSVFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q58AA7</accession>
    <name>Q58AA7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sas10 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_T01B7.5</name>
        <name evidence="3 5" type="ORF">T01B7.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAI70408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q58AA7"/>
    <dbReference type="SMR" id="Q58AA7"/>
    <dbReference type="PeptideAtlas" id="Q58AA7"/>
    <dbReference type="UCSC" id="T01B7.5a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00011311"/>
    <dbReference type="WormBase" id="T01B7.5b">
        <property type="protein sequence ID" value="CE38216"/>
        <property type="gene ID" value="WBGene00011311"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676589_0_0_1"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011311">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q58AA7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAI70408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T01B7.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q58AA7"/>
        </source>
    </evidence>
    <sequence length="189" mass="21608" checksum="1897C2AADB46CB33" modified="2005-04-26" version="1">MNTAFLLNLRAKQFSNEKLDDPLVDIHPVVESLKRLEKKITECEDFLHSNSDHLDELKKWAESEPENMEELISKVGDVQLTKKNFGAIMNNNLSTITSSDNTSIHPHFTPMDADEKRKASDKVAKNREYAERRGKKKAKTSKTKNRRKVHAIEKRVKSQIGNVRREMQKYSGETSGIRASTIKSTKLIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q7JKY3-2</accession>
    <name>DPF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Dipeptidyl peptidase family member 1</fullName>
            <ecNumber>3.4.14.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dpf-1</name>
        <name type="ORF">T23F1.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="book" date="2005" name="Proceedings of the 15th international C. elegans meeting" first="402" last="402" publisher="Los Angeles">
            <title>Dipeptidyl peptidase IV-like protease family is essential for control of distal tip cell migration in C. elegans.</title>
            <authorList>
                <person name="Yoshina S."/>
                <person name="Gengyo-Ando K."/>
                <person name="Mitani S."/>
                <person name="Iino Y."/>
                <person name="Inoue H."/>
                <person name="Takahashi K."/>
            </authorList>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-512</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q7JKY3-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_020298"/>
        </isoform>
        <isoform>
            <id>Q7JKY3-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.14.-"/>
    <dbReference type="RefSeq" id="NP_506851.1">
        <property type="nucleotide sequence ID" value="NM_074450.7"/>
    </dbReference>
    <dbReference type="WormBase" id="T23F1.7a">
        <property type="protein sequence ID" value="CE21195"/>
        <property type="gene ID" value="WBGene00001054"/>
        <property type="gene designation" value="dpf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="779" mass="88980" checksum="40418EE0478FC3D7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IA78</accession>
    <name>Q8IA78_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">ugt-39</name>
        <name evidence="12" type="ORF">CELE_F10D2.2</name>
        <name evidence="14" type="ORF">F10D2.2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD69117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370646.1">
        <property type="nucleotide sequence ID" value="NM_001383331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IA78"/>
    <dbReference type="SMR" id="Q8IA78"/>
    <dbReference type="CAZy" id="GT1">
        <property type="family name" value="Glycosyltransferase Family 1"/>
    </dbReference>
    <dbReference type="GeneID" id="3564933"/>
    <dbReference type="KEGG" id="cel:CELE_F10D2.2"/>
    <dbReference type="UCSC" id="F10D2.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017329"/>
    <dbReference type="CTD" id="3564933"/>
    <dbReference type="WormBase" id="F10D2.2b">
        <property type="protein sequence ID" value="CE32861"/>
        <property type="gene ID" value="WBGene00017329"/>
        <property type="gene designation" value="ugt-39"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012949_1_4_1"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017329">
        <property type="expression patterns" value="Expressed in material anatomical entity and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IA78">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF42">
        <property type="entry name" value="GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD69117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F10D2.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q8IA78"/>
        </source>
    </evidence>
    <sequence length="370" mass="41854" checksum="B8D7AD560FF381EC" modified="2003-03-01" version="1">MDYLEIPTFIPSVSVAHDTSLAIEIGEPVMPSVVSDCLSPFGDKLSITERAFNAFMVPYFDFMIGYPTHRSFKPPYNPIDIRSIVPEASFVFLNSNPFVDFPRPTLTKTIQIGGISVDSNELRSQKLDETWSEILKLREKTMLVSFGSMLYSKDMPFKNKIALKNAMEKFKNVTFIWKYEDDSSDEFAKGIENIHFAKWVPQTALLADSRLSAFLTHAGLGSINELSYLGKPAILCPQLFDQMRNAKMLVRHNGSIELSKYDLGDSEKIVNAFQAILFDSSYAKNALKLAEQLENQPIKPKEMMVKHAEFAARFGRLPSLDPYSRKMTFIEYFLIDVAAISMVVLIAVVFVITKMFKILCNKTSVKGKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IA84</accession>
    <name>Q8IA84_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rap-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CELE_F53A10.2</name>
        <name evidence="5 7" type="ORF">F53A10.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD71457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IA84"/>
    <dbReference type="SMR" id="Q8IA84"/>
    <dbReference type="PeptideAtlas" id="Q8IA84"/>
    <dbReference type="UCSC" id="F53A10.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018734"/>
    <dbReference type="WormBase" id="F53A10.2b">
        <property type="protein sequence ID" value="CE32671"/>
        <property type="gene ID" value="WBGene00018734"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010739_1_0_1"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018734">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IA84">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF32">
        <property type="entry name" value="RAP GTPASE ACTIVATING PROTEIN 1, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="296"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD71457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F53A10.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q8IA84"/>
        </source>
    </evidence>
    <sequence length="376" mass="41879" checksum="A52EE980B06D9827" modified="2003-03-01" version="1">MFHVSTMLPYTIGDAQQLQRKRHIGNDIVAIIFQEANTPFAPDMIASNFLHAYVVVQPIDALTDRVRYRVSVAARDDVPFFGPTLPTPSIFKRGQDFRNFLLTKLINAENAAYKSSKFAKLAERTRSSLLDGLHATLRERAEFYATPLLESTSSGGESAATTSSSSNSYGGGILSSVKKAFIGRSRSVSQEASHVPHRAATINVTSRPKKSISSTSSSTSARTHSPIRDEEVVKPYRKEWEISSQESPDNEHDSDTGMESMSSTEMSGQTRASSCTFCVDDFHVAANHQSSDAKRLETLCVDVTRLQNEKHDLLRQNVSCKTDIKKLKDRQSVLSEELERANDEISRLRRMLKKPSNSDMAPVHQHFERSYSDVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IA87</accession>
    <name>Q8IA87_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F44E7.5</name>
        <name evidence="1 3" type="ORF">F44E7.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD67865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_872177.1">
        <property type="nucleotide sequence ID" value="NM_182377.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IA87"/>
    <dbReference type="GeneID" id="178967"/>
    <dbReference type="UCSC" id="F44E7.5b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018427"/>
    <dbReference type="CTD" id="178967"/>
    <dbReference type="WormBase" id="F44E7.5b">
        <property type="protein sequence ID" value="CE33094"/>
        <property type="gene ID" value="WBGene00018427"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1205712_0_0_1"/>
    <dbReference type="OrthoDB" id="5807103at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018427">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IA87">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD67865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F44E7.5b"/>
        </source>
    </evidence>
    <sequence length="230" mass="26465" checksum="BC5C3570C0FC75FB" modified="2003-03-01" version="1">MELSTDLWEKISYSLADHPPSLCLLSKSSSKLRELVQFVIGHYEAHLHITLPKDECCDEEKCSKEKVQFEMILNRKGSYRRGRAHFHSIFTCLTDKIDLAVNDLLELFAKELITLRFNNFPENSDVFTVFNKHSLPKCEDICFNGSLPVHNGVSDMFHSCHNMKRLVISNPNTDTDFSQFWPKLKGSKVETLDLMGHRVIPPHFHERVQASIKLETTFLLSKARSQVQAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IA89</accession>
    <name>Q8IA89_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Insulin-degrading enzyme</fullName>
            <ecNumber evidence="8">3.4.24.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Insulin protease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Insulysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CELE_F44E7.4</name>
        <name evidence="16 18" type="ORF">F44E7.4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Degradation of insulin, glucagon and other polypeptides. No action on proteins.</text>
            <dbReference type="EC" id="3.4.24.56"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.56" evidence="8"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD67862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_504514.2">
        <property type="nucleotide sequence ID" value="NM_072113.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IA89"/>
    <dbReference type="SMR" id="Q8IA89"/>
    <dbReference type="MEROPS" id="M16.A09"/>
    <dbReference type="PeptideAtlas" id="Q8IA89"/>
    <dbReference type="GeneID" id="178966"/>
    <dbReference type="UCSC" id="F44E7.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018426"/>
    <dbReference type="CTD" id="178966"/>
    <dbReference type="WormBase" id="F44E7.4c">
        <property type="protein sequence ID" value="CE33092"/>
        <property type="gene ID" value="WBGene00018426"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7784541at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018426">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 5 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IA89">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000066">
        <property type="entry name" value="Putative zinc protease mug138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="14">
        <location>
            <begin position="200"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="15">
        <location>
            <begin position="385"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="15">
        <location>
            <begin position="608"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="14">
        <location>
            <begin position="688"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD67862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="F44E7.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="Q8IA89"/>
        </source>
    </evidence>
    <sequence length="1008" mass="115416" checksum="30F8436FABF51B7E" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IA98</accession>
    <accession>Q9BL01</accession>
    <name>CASP_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ceh-44</name>
        <name type="ORF">Y54F10AM.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Int. J. Dev. Biol." volume="46" first="115" last="123">
            <title>Loss and gain of domains during evolution of cut superclass homeobox genes.</title>
            <authorList>
                <person name="Buerglin T.R."/>
                <person name="Cassata G."/>
            </authorList>
            <dbReference type="PubMed" id="11902672"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Mol. Biol. Cell" volume="13" first="3761" last="3774">
            <title>CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin.</title>
            <authorList>
                <person name="Gillingham A.K."/>
                <person name="Pfeifer A.C."/>
                <person name="Munro S."/>
            </authorList>
            <dbReference type="PubMed" id="12429822"/>
            <dbReference type="DOI" id="10.1091/mbc.E02-06-0349"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in intra-Golgi retrograde transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q8IA98-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q8IA98-2</id>
            <name>c</name>
            <sequence type="described" ref="VSP_017009"/>
        </isoform>
        <isoform>
            <id>Q9BL02-1</id>
            <name>a</name>
            <sequence type="external"/>
        </isoform>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="FO081806">
        <property type="protein sequence ID" value="CCD73823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FO081806">
        <property type="protein sequence ID" value="CCD73824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_497575.2">
        <molecule id="Q8IA98-2"/>
        <property type="nucleotide sequence ID" value="NM_065174.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_497577.2">
        <molecule id="Q8IA98-1"/>
        <property type="nucleotide sequence ID" value="NM_065176.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8IA98"/>
    <dbReference type="SMR" id="Q8IA98"/>
    <dbReference type="BioGRID" id="40620">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q8IA98"/>
    <dbReference type="EnsemblMetazoa" id="Y54F10AM.4b.1">
        <property type="protein sequence ID" value="Y54F10AM.4b.1"/>
        <property type="gene ID" value="WBGene00000464"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="Y54F10AM.4c.1">
        <property type="protein sequence ID" value="Y54F10AM.4c.1"/>
        <property type="gene ID" value="WBGene00000464"/>
    </dbReference>
    <dbReference type="KEGG" id="cel:CELE_Y54F10AM.16"/>
    <dbReference type="UCSC" id="Y54F10AM.4c">
        <molecule id="Q8IA98-1"/>
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00306126"/>
    <dbReference type="WormBase" id="Y54F10AM.4b">
        <molecule id="Q8IA98-2"/>
        <property type="protein sequence ID" value="CE32987"/>
        <property type="gene ID" value="WBGene00000464"/>
        <property type="gene designation" value="ceh-44"/>
    </dbReference>
    <dbReference type="WormBase" id="Y54F10AM.4c">
        <molecule id="Q8IA98-1"/>
        <property type="protein sequence ID" value="CE32988"/>
        <property type="gene ID" value="WBGene00000464"/>
        <property type="gene designation" value="ceh-44"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_441623_0_0_1"/>
    <dbReference type="OMA" id="WQQEGFN"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000464">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8IA98">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0025">Alternative splicing</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000071793" description="Protein CASP">
        <location>
            <begin position="1"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Anchor for type IV membrane protein" evidence="2">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="101"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="473"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="splice variant" id="VSP_017009" description="In isoform c." evidence="3">
        <original>DFR</original>
        <variation>E</variation>
        <location>
            <begin position="541"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="621" mass="70952" checksum="F75BF5E889583BCB" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q8IA98-2</accession>
    <name>CASP_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ceh-44</name>
        <name type="ORF">Y54F10AM.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Int. J. Dev. Biol." volume="46" first="115" last="123">
            <title>Loss and gain of domains during evolution of cut superclass homeobox genes.</title>
            <authorList>
                <person name="Buerglin T.R."/>
                <person name="Cassata G."/>
            </authorList>
            <dbReference type="PubMed" id="11902672"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Mol. Biol. Cell" volume="13" first="3761" last="3774">
            <title>CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin.</title>
            <authorList>
                <person name="Gillingham A.K."/>
                <person name="Pfeifer A.C."/>
                <person name="Munro S."/>
            </authorList>
            <dbReference type="PubMed" id="12429822"/>
            <dbReference type="DOI" id="10.1091/mbc.E02-06-0349"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9BL02-1</id>
            <name>a</name>
            <sequence type="external"/>
        </isoform>
        <isoform>
            <id>Q8IA98-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q8IA98-2</id>
            <name>c</name>
            <sequence type="described" ref="VSP_017009"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_497575.2">
        <property type="nucleotide sequence ID" value="NM_065174.5"/>
    </dbReference>
    <dbReference type="WormBase" id="Y54F10AM.4b">
        <property type="protein sequence ID" value="CE32987"/>
        <property type="gene ID" value="WBGene00000464"/>
        <property type="gene designation" value="ceh-44"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="619" mass="70663" checksum="96D9438ED7F7E790" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-05-09" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MPX3-2</accession>
    <name>DNJ20_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of DnaJ homolog dnj-20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>DnaJ domain protein 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnj-20</name>
        <name evidence="1" type="ORF">T15H9.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q8MPX3-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_036008"/>
        </isoform>
        <isoform>
            <id>Q8MPX3-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_496072.2">
        <property type="nucleotide sequence ID" value="NM_063671.5"/>
    </dbReference>
    <dbReference type="WormBase" id="T15H9.7b">
        <property type="protein sequence ID" value="CE30689"/>
        <property type="gene ID" value="WBGene00001038"/>
        <property type="gene designation" value="dnj-20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="T15H9.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T15H9.7b"/>
        </source>
    </evidence>
    <sequence length="82" mass="9417" checksum="7A6C31DA1BE0FD77" modified="2008-12-16" version="2" precursor="true">MEIQHLDGHIVKVQRDKVTWPGARLRKKDEGMPSLEDNNKKGMLVVTFDVEFPKTELSDEQKAQIIEILQQNTVKPKAYNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QX9</accession>
    <name>Q95QX9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuropeptide-Like Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C04H5.7</name>
        <name evidence="2" type="ORF">CELE_C04H5.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAC42248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001366983.1">
        <property type="nucleotide sequence ID" value="NM_001381662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q95QX9"/>
    <dbReference type="PeptideAtlas" id="Q95QX9"/>
    <dbReference type="GeneID" id="175115"/>
    <dbReference type="UCSC" id="C04H5.7b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007315"/>
    <dbReference type="CTD" id="175115"/>
    <dbReference type="WormBase" id="C04H5.7b">
        <property type="protein sequence ID" value="CE27793"/>
        <property type="gene ID" value="WBGene00007315"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3160439_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007315">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q95QX9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004321644" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC42248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C04H5.7b"/>
        </source>
    </evidence>
    <sequence length="48" mass="5668" checksum="0A8165FD6D3BEEC6" modified="2001-12-01" version="1">MKLFIFVLLFLLTINVLAESHESHENSGRVSVMSSEKLWTGRIWIFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QZ3</accession>
    <name>Q95QZ3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ntl-2</name>
        <name evidence="8" type="ORF">B0286.4</name>
        <name evidence="6" type="ORF">CELE_B0286.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379564.1">
        <property type="nucleotide sequence ID" value="NM_001393050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q95QZ3"/>
    <dbReference type="SMR" id="Q95QZ3"/>
    <dbReference type="PeptideAtlas" id="Q95QZ3"/>
    <dbReference type="GeneID" id="173773"/>
    <dbReference type="UCSC" id="B0286.4a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003825"/>
    <dbReference type="CTD" id="173773"/>
    <dbReference type="WormBase" id="B0286.4c">
        <property type="protein sequence ID" value="CE29538"/>
        <property type="gene ID" value="WBGene00003825"/>
        <property type="gene designation" value="ntl-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033275_2_0_1"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003825">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q95QZ3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000005">
        <property type="entry name" value="Regena, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="100"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD61666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="B0286.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q95QZ3"/>
        </source>
    </evidence>
    <sequence length="317" mass="34734" checksum="63043956E47ABAD9" modified="2001-12-01" version="1">MLADDHQVDFAGPLGDCDPSRLSGISRNSQEGPMHGIITHPDGEVTNIPASMLDDQFGMAGLVTYLRTVDNPSIVSLALGYDLTTLGLNLNLSERKLYMNFGGPWADSPIRAHELDVKVPEEYMTHNHIRDKLPPLRLNKVSEDVLFYLFYNCPNEIYQVAAACELYAREWRFHKSEQVWLTRSQYGGVKEQTGNYEKGHYNVFDQMQWRKIPKELKLEYKELEDRPKMPQSVSGQPTPYKYFFQGPQFPSGPETGLMLQMHNLTLGTGGGGGGQITPPAPAGLNGVMGGGGVGAAGIGGINVQPGAVPSAARATPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2025-10-08" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QZ4</accession>
    <name>Q95QZ4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ntl-2</name>
        <name evidence="8" type="ORF">B0286.4</name>
        <name evidence="6" type="ORF">CELE_B0286.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD61665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_494773.1">
        <property type="nucleotide sequence ID" value="NM_062372.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q95QZ4"/>
    <dbReference type="SMR" id="Q95QZ4"/>
    <dbReference type="PeptideAtlas" id="Q95QZ4"/>
    <dbReference type="GeneID" id="173773"/>
    <dbReference type="UCSC" id="B0286.4a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003825"/>
    <dbReference type="CTD" id="173773"/>
    <dbReference type="WormBase" id="B0286.4b">
        <property type="protein sequence ID" value="CE29537"/>
        <property type="gene ID" value="WBGene00003825"/>
        <property type="gene designation" value="ntl-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003825">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q95QZ4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000005">
        <property type="entry name" value="Regena, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="150"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD61665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="B0286.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="Q95QZ4"/>
        </source>
    </evidence>
    <sequence length="367" mass="40139" checksum="782D2BEE35BBCA26" modified="2001-12-01" version="1">MLATSFPNLMRSDPSLTNPEFQIQNEDFPALPGVGSGQTQRSMLGDQLANMLADDHQVDFAGPLGDCDPSRLSGISRNSQEGPMHGIITHPDGEVTNIPASMLDDQFGMAGLVTYLRTVDNPSIVSLALGYDLTTLGLNLNLSERKLYMNFGGPWADSPIRAHELDVKVPEEYMTHNHIRDKLPPLRLNKVSEDVLFYLFYNCPNEIYQVAAACELYAREWRFHKSEQVWLTRSQYGGVKEQTGNYEKGHYNVFDQMQWRKIPKELKLEYKELEDRPKMPQSVSGQPTPYKYFFQGPQFPSGPETGLMLQMHNLTLGTGGGGGGQITPPAPAGLNGVMGGGGVGAAGIGGINVQPGAVPSAARATPN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-13" modified="2026-01-28" version="165" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XTY6-3</accession>
    <name>NUMB1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Numb-related protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>CKA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Protein kinase C adapter 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">num-1</name>
        <name type="synonym">cka-1</name>
        <name type="ORF">T03D8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="10463" last="10475">
            <title>A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3.</title>
            <authorList>
                <person name="Zhang L."/>
                <person name="Wu S.-L."/>
                <person name="Rubin C.S."/>
            </authorList>
            <dbReference type="PubMed" id="11134024"/>
            <dbReference type="DOI" id="10.1074/jbc.M008990200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND C)</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PKC-3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF PHE-175 AND PHE-221</scope>
        <source>
            <strain evidence="1">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="10476" last="10484">
            <title>Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery.</title>
            <authorList>
                <person name="Zhang L."/>
                <person name="Wu S.-L."/>
                <person name="Rubin C.S."/>
            </authorList>
            <dbReference type="PubMed" id="11134025"/>
            <dbReference type="DOI" id="10.1074/jbc.M008991200"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH PKC-3</scope>
        <scope>PHOSPHORYLATION AT SER-17 AND SER-65</scope>
        <scope>MUTAGENESIS OF SER-17 AND SER-65</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <event type="alternative initiation"/>
        <isoform>
            <id>Q9XTY6-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_051599 VSP_051598"/>
        </isoform>
        <isoform>
            <id>Q9XTY6-1</id>
            <name evidence="1">a</name>
            <name evidence="2">cka1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9XTY6-4</id>
            <name>c</name>
            <sequence type="described" ref="VSP_018786"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Produced by alternative splicing.</text>
    </comment>
    <dbReference type="RefSeq" id="NP_001024097.1">
        <property type="nucleotide sequence ID" value="NM_001028926.5"/>
    </dbReference>
    <dbReference type="WormBase" id="T03D8.1b">
        <property type="protein sequence ID" value="CE18919"/>
        <property type="gene ID" value="WBGene00003830"/>
        <property type="gene designation" value="num-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="11134024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="11134024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAK28740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T03D8.1c"/>
        </source>
    </evidence>
    <sequence length="401" mass="44265" checksum="FDCFB67BD4F91E2A" modified="1999-11-01" version="1">MVLIDTEYVRAVVHNVGHRARCGVASKVRALKLAHSQARLRSYSQACERASYIDGRCEYYPSLDVASSSRNSEMLNSGFFDGYSWNTPNIQSQSSSDVTAKTELRRLMTETSEDPIHKEDSETLRRLIMWQEFRDAGVDVNTTQPGYGYGIEAKVEPFPQKLQNYESIHLETRRSSCPSFGTQLYNEPIYEGDEDPLGLGITPPVVTKTSGSLSNNGLDGINLNWKSIPAPVHQMQQHNANGDFVAAWPQNTIEKPTVGPLDKLQKQFEDIKLISISSGENTPTTRSKADEWLDDVLRVSMSMSPTSPSSDPPSTSSYSVLPKSGPPPAHAPPPLPVRQAVSNGSPSIYQQQLQQANSTRNSPAGINWNSSPNPMKISQPPAKPVDPFDVQWSRLAVNNTH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-13" modified="2026-01-28" version="165" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XTY6-4</accession>
    <name>NUMB1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Numb-related protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>CKA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Protein kinase C adapter 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">num-1</name>
        <name type="synonym">cka-1</name>
        <name type="ORF">T03D8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="10463" last="10475">
            <title>A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3.</title>
            <authorList>
                <person name="Zhang L."/>
                <person name="Wu S.-L."/>
                <person name="Rubin C.S."/>
            </authorList>
            <dbReference type="PubMed" id="11134024"/>
            <dbReference type="DOI" id="10.1074/jbc.M008990200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND C)</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH PKC-3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF PHE-175 AND PHE-221</scope>
        <source>
            <strain evidence="1">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="10476" last="10484">
            <title>Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery.</title>
            <authorList>
                <person name="Zhang L."/>
                <person name="Wu S.-L."/>
                <person name="Rubin C.S."/>
            </authorList>
            <dbReference type="PubMed" id="11134025"/>
            <dbReference type="DOI" id="10.1074/jbc.M008991200"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH PKC-3</scope>
        <scope>PHOSPHORYLATION AT SER-17 AND SER-65</scope>
        <scope>MUTAGENESIS OF SER-17 AND SER-65</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <event type="alternative initiation"/>
        <isoform>
            <id>Q9XTY6-1</id>
            <name evidence="1">a</name>
            <name evidence="2">cka1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9XTY6-4</id>
            <name>c</name>
            <sequence type="described" ref="VSP_018786"/>
        </isoform>
        <isoform>
            <id>Q9XTY6-3</id>
            <name>b</name>
            <sequence type="described" ref="VSP_051599 VSP_051598"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Produced by alternative initiation at Met-45 of isoform a.</text>
    </comment>
    <dbReference type="RefSeq" id="NP_001024098.1">
        <property type="nucleotide sequence ID" value="NM_001028927.3"/>
    </dbReference>
    <dbReference type="WormBase" id="T03D8.1c">
        <property type="protein sequence ID" value="CE30563"/>
        <property type="gene ID" value="WBGene00003830"/>
        <property type="gene designation" value="num-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="11134024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="11134024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAK28740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T03D8.1c"/>
        </source>
    </evidence>
    <sequence length="549" mass="60679" checksum="A126F40585F20FF5" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-24" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XUE6-2</accession>
    <name>PMM_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Probable phosphomannomutase</fullName>
            <shortName>PMM</shortName>
            <ecNumber>5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">F52B11.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9XUE6-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_041635"/>
        </isoform>
        <isoform>
            <id>Q9XUE6-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="5.4.2.8"/>
    <dbReference type="RefSeq" id="NP_001255787.1">
        <property type="nucleotide sequence ID" value="NM_001268858.3"/>
    </dbReference>
    <dbReference type="WormBase" id="F52B11.2b">
        <property type="protein sequence ID" value="CE36163"/>
        <property type="gene ID" value="WBGene00009925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="225" mass="25777" checksum="A0F807E15A4DCD45" modified="2011-07-27" version="2">MREFLIEARKRVPLAIVGGSDFKKITEQLADHDKDLLLSLFDYTFSENGLYGFKGTEPYPVQSIQKAIGDAKLQELINFALRYMSDIQLPVKRGNFVEFRNGMINLSPIGRSCSQEERMQFVEFDKKHGIRQKFTEQLREKFGQYGLQFAIGGQISVDVFPTGWDKTFCLQYLVPDFDTIHFFGDKTAPGGNDHEIFADERTVGHTVEGPEDTRKHVENVLKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXU0</accession>
    <name>Q9XXU0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y9C2UA.1</name>
        <name evidence="2 4" type="ORF">Y9C2UA.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAA15517.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T27485">
        <property type="entry name" value="T27485"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XXU0"/>
    <dbReference type="UCSC" id="Y9C2UA.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012421"/>
    <dbReference type="WormBase" id="Y9C2UA.1a">
        <property type="protein sequence ID" value="CE33005"/>
        <property type="gene ID" value="WBGene00012421"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802220_0_0_1"/>
    <dbReference type="OrthoDB" id="5848162at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012421">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XXU0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA15517.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y9C2UA.1a"/>
        </source>
    </evidence>
    <sequence length="343" mass="38606" checksum="C64C3F1743E09376" modified="2003-03-01" version="2">MGNSASAKQVADQVAYGVISCITVGVLIVMLYMSVFGQRVRATAVRWHVLNCSLWGILHLISYASFAEKAPWPNYITNQNWRDTARQVECFTRSVFPAGMVFVYLEQIILTIAPKLANSIVFNAIFFILLIPFLNGLMIFLYYAHFMDIVWWYEPIDLFNLATYLIFTTFTFIYFLFCLFGTCLCCATMTSKKPSSRTTGTFADMWLLFPYGLIPSIMYGPSFGMTSVSFAMQHLLTWVLESGLLTGGGGSSSGGSFIDMNLLMQVATNAILAMPWFVLLFPLVQSILALVCLRMFREQFFFMISCGRIFEGKRAKIGMTEWNVTSIGPPPLYPNSPSEKQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKS9</accession>
    <name>A0A061AKS9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pqn-74</name>
        <name evidence="2" type="ORF">CELE_W02A2.3</name>
        <name evidence="4" type="ORF">W02A2.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380173.1">
        <property type="nucleotide sequence ID" value="NM_001392428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AKS9"/>
    <dbReference type="SMR" id="A0A061AKS9"/>
    <dbReference type="GeneID" id="178294"/>
    <dbReference type="KEGG" id="cel:CELE_W02A2.3"/>
    <dbReference type="AGR" id="WB:WBGene00004156"/>
    <dbReference type="CTD" id="178294"/>
    <dbReference type="WormBase" id="W02A2.3b">
        <property type="protein sequence ID" value="CE49768"/>
        <property type="gene ID" value="WBGene00004156"/>
        <property type="gene designation" value="pqn-74"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056625_0_0_1"/>
    <dbReference type="OrthoDB" id="5829832at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004156">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AKS9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR32691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="W02A2.3b"/>
        </source>
    </evidence>
    <sequence length="277" mass="30540" checksum="FCDE3F46881E13AA" modified="2014-09-03" version="1">MQFLVEETREAPRQCACPNGEQNCVCPSPEILEPISAVKKVRRSAQQQPLRFSQYPSCPCPQNQPACTCSTNNQQNEQILVSISCCQQQETTTQAPVQMQPCQCTPTQIQQNCQTTTTQQQYCPQQSAPVVQPQPCPLVQGSGVQNAQYQGICSWMIDPLATDPQSRTHYLQCQPAPNNLFCGRWQRMPCAPGTVFDVQSQVCVWDTNSQPGTLPTPAPYVSTQAPQNAQCGCTGGVQIGSCNQNYQCPGQSVCQVGQNAGQQCMVCCYFRKKARRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKU6</accession>
    <name>A0A061AKU6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Enoyl-CoA Hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ech-9</name>
        <name evidence="7" type="ORF">CELE_F01G10.3</name>
        <name evidence="9" type="ORF">F01G10.3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368477.1">
        <property type="nucleotide sequence ID" value="NM_001380437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AKU6"/>
    <dbReference type="SMR" id="A0A061AKU6"/>
    <dbReference type="GeneID" id="184065"/>
    <dbReference type="KEGG" id="cel:CELE_F01G10.3"/>
    <dbReference type="AGR" id="WB:WBGene00001158"/>
    <dbReference type="CTD" id="184065"/>
    <dbReference type="WormBase" id="F01G10.3b">
        <property type="protein sequence ID" value="CE49962"/>
        <property type="gene ID" value="WBGene00001158"/>
        <property type="gene designation" value="ech-9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_1"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001158">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AKU6">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000796">
        <property type="entry name" value="Enoyl-CoA Hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.50:FF:000006">
        <property type="entry name" value="Peroxisomal bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23309">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23309:SF16">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="6">
        <location>
            <begin position="29"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="208"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR32706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F01G10.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AKU6"/>
        </source>
    </evidence>
    <sequence length="422" mass="47895" checksum="6FBA677E8F1866BF" modified="2014-09-03" version="1">MEAHSLAGQWSLPNDRGDHTNSEAYDVNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQRCKQELEVMYAREKSFKRLNDKRIEKINANLKITSDFHKLSNCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSSQAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEYGYLPHQIDKIITNFGFLMGPMTVADMNGFDVMEKLKKENGLEPNPIEKEMWRLKRYGRKTNKGFYKYDDKTQRKENDTEMEQIIRRVSQNAKSNIQIINDQDVINFMLYPTVNEGYRCIEEGVISNESLIDIMFILGFGWPIHSGGPMRFGKTEGLDKIANMLVHWSSLEPKESAYIVADALKTANNKLMSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKV6</accession>
    <name>A0A061AKV6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GB1/RHD3-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">atln-2</name>
        <name evidence="6" type="ORF">CELE_Y41E3.3</name>
        <name evidence="8" type="ORF">Y41E3.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368480.1">
        <property type="nucleotide sequence ID" value="NM_001380543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AKV6"/>
    <dbReference type="SMR" id="A0A061AKV6"/>
    <dbReference type="GeneID" id="189829"/>
    <dbReference type="AGR" id="WB:WBGene00012763"/>
    <dbReference type="CTD" id="189829"/>
    <dbReference type="WormBase" id="Y41E3.3d">
        <property type="protein sequence ID" value="CE49857"/>
        <property type="gene ID" value="WBGene00012763"/>
        <property type="gene designation" value="atln-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021447_0_1_1"/>
    <dbReference type="OrthoDB" id="7788754at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012763">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AKV6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.420:FF:000003">
        <property type="entry name" value="ATLastiN (Endoplasmic reticulum GTPase) related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003207">
        <property type="entry name" value="ATLastiN (Endoplasmic reticulum GTPase) related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDR32717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y41E3.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AKV6"/>
        </source>
    </evidence>
    <sequence length="315" mass="36491" checksum="F7E6DE8DACCB2F99" modified="2014-09-03" version="1">MIESVTGEMFAVVLMDTQGTFDNNSTYQQCMTVFALSTIVSSVQIYNVVDNIQEDALQHLSLFVEYGRIAMEQPHNFGKPFQQLVFCVRDFKNQEEYEFGENGGTDFLDNVLQTNPEQPEEIKQVRELLREYFEDIQCYLLPHPGYKVAERQSFRGHVKDLRPLFREELKKMVPNLLGPHILKPKIVNGKTVTCRKMIQYFKEYAASFDGETLPQPQSILNANAKLICIEAAHEAKVNYSRGMDRSTYGTRMMSEKKLLEAHIKHGITALNIFDKCPRIGAKEVRNLLLEKLQEDINVGFWETFFDFKAEYLWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKW2</accession>
    <name>A0A061AKW2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">afmd-2</name>
        <name evidence="1" type="ORF">CELE_Y45F10A.3</name>
        <name evidence="3" type="ORF">Y45F10A.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293953.1">
        <property type="nucleotide sequence ID" value="NM_001307024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AKW2"/>
    <dbReference type="SMR" id="A0A061AKW2"/>
    <dbReference type="PeptideAtlas" id="A0A061AKW2"/>
    <dbReference type="GeneID" id="189911"/>
    <dbReference type="AGR" id="WB:WBGene00012866"/>
    <dbReference type="CTD" id="189911"/>
    <dbReference type="WormBase" id="Y45F10A.3c">
        <property type="protein sequence ID" value="CE49803"/>
        <property type="gene ID" value="WBGene00012866"/>
        <property type="gene designation" value="afmd-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_7_1"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012866">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AKW2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR32722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y45F10A.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AKW2"/>
        </source>
    </evidence>
    <sequence length="69" mass="8288" checksum="300CA0AAD2F11388" modified="2014-09-03" version="1">MKHVRFPVLIACCRRESPKLYQQNQDFSSQVANAQYKEYENEDHFTILTELTKEESIVYADFFNFLYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKW6</accession>
    <name>A0A061AKW6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BMERB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F08G5.3</name>
        <name evidence="3 5" type="ORF">F08G5.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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    <dbReference type="CTD" id="184204"/>
    <dbReference type="WormBase" id="F08G5.3d">
        <property type="protein sequence ID" value="CE49775"/>
        <property type="gene ID" value="WBGene00008582"/>
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    <dbReference type="Proteomes" id="UP000001940">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
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        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR32727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F08G5.3d"/>
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    </evidence>
    <sequence length="132" mass="15594" checksum="74AB89715F73A44C" modified="2014-09-03" version="1">MPEFQERLTYLDKRYDHLRKMTHSLRKKVNELEDIMRLDNDEENMDTIQKLLDEIKREKQLMRDEAHIIKGELSKTMYNEDLRRRLAGEWKKIDADRKSSAAESEASSSMIGDDDTPSTSSDGHKPYRETSM</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="WormBase" id="F12F6.3b"/>
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    </evidence>
    <sequence length="51" mass="6199" checksum="44D558EC1AAE22B1" modified="2014-09-03" version="1">MSTSRRRVKELRESARNVYDAYLRSIQVISDHVLRIIFKRIDNKIELEDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <reference evidence="3 4" key="1">
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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        <property type="nucleotide sequence ID" value="NM_001307043.3"/>
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        <property type="gene designation" value="spp-18"/>
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    <dbReference type="HOGENOM" id="CLU_162209_0_0_1"/>
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AKY5">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAP_B"/>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saposin B-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR32742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F27C8.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AKY5"/>
        </source>
    </evidence>
    <sequence length="92" mass="10272" checksum="D665E6A41F3B30D5" modified="2014-09-03" version="1">MAKRYVPSQNSDATCEICLDLVLIAETYAECDEAIVQHHMDAYCVEHVKNHASQALCKLLIDDIAHAVIEDTDQNPTGVCQKVIHKTCPYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AL62</accession>
    <name>A0A061AL62_CAEEL</name>
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        <submittedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">egl-23</name>
        <name evidence="12" type="ORF">CELE_Y37A1B.11</name>
        <name evidence="14" type="ORF">Y37A1B.11</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDR32782.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="NP_001293999.1">
        <property type="nucleotide sequence ID" value="NM_001307070.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AL62"/>
    <dbReference type="SMR" id="A0A061AL62"/>
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    <dbReference type="AGR" id="WB:WBGene00001190"/>
    <dbReference type="CTD" id="178358"/>
    <dbReference type="WormBase" id="Y37A1B.11c">
        <property type="protein sequence ID" value="CE49787"/>
        <property type="gene ID" value="WBGene00001190"/>
        <property type="gene designation" value="egl-23"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF317">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="172"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="306"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="603"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDR32782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="Y37A1B.11c"/>
        </source>
    </evidence>
    <sequence length="684" mass="76254" checksum="F938B6B08A255ED5" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AL65</accession>
    <name>A0A061AL65_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cpt-2</name>
        <name evidence="3" type="ORF">CELE_R07H5.2</name>
        <name evidence="5" type="ORF">R07H5.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294004.1">
        <property type="nucleotide sequence ID" value="NM_001307075.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AL65"/>
    <dbReference type="SMR" id="A0A061AL65"/>
    <dbReference type="GeneID" id="178025"/>
    <dbReference type="AGR" id="WB:WBGene00011122"/>
    <dbReference type="CTD" id="178025"/>
    <dbReference type="WormBase" id="R07H5.2c">
        <property type="protein sequence ID" value="CE49980"/>
        <property type="gene ID" value="WBGene00011122"/>
        <property type="gene designation" value="cpt-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_4_2_1"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011122">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AL65">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000202">
        <property type="entry name" value="Carnitine Palmitoyl Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR32787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="R07H5.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AL65"/>
        </source>
    </evidence>
    <sequence length="109" mass="11802" checksum="487C8D80BF2C1A58" modified="2014-09-03" version="1">MGQGYDRHLLGLKITAQRLSQPTPDFFQDPGYTRMGHFVLSTSTLSTDTIVFGGFGPVVQDGFGIGYNVVPNKLGAVISSNKSKRDAAAFSNALYKSLDILRGHLLDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AL70</accession>
    <name>A0A061AL70_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">sru-20</name>
        <name evidence="2" type="ORF">CELE_T04A11.7</name>
        <name evidence="4" type="ORF">T04A11.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32792.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343704.1">
        <property type="nucleotide sequence ID" value="NM_001356934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AL70"/>
    <dbReference type="GeneID" id="188045"/>
    <dbReference type="AGR" id="WB:WBGene00005683"/>
    <dbReference type="CTD" id="188045"/>
    <dbReference type="WormBase" id="T04A11.7c">
        <property type="protein sequence ID" value="CE52141"/>
        <property type="gene ID" value="WBGene00005683"/>
        <property type="gene designation" value="sru-20"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049496_0_1_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005683">
        <property type="expression patterns" value="Expressed in embryo"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AL70">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003839">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sru"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46045:SF8">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46045">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS U-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10322">
        <property type="entry name" value="7TM_GPCR_Sru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR32792.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T04A11.7c"/>
        </source>
    </evidence>
    <sequence length="222" mass="26119" checksum="A107E84B715FEE80" modified="2017-12-20" version="2">MIYPVLLIVVRITPIQYPQSHREINSKILAYSIPFIHIYPIFFILHMIPALGVCRQLWKPYPFGCAFIHFYGSWHDLKNSPFEVINSVLWLIIFLICNFKLYQKIQNLKGTSRGNSNVNQSSRYRRAEISLTLTSGSMILTYIVNFIFQASLNQPKIWNLPFFQGTFIINFTLMTYSSFFRPYGYDLETCVVPWMLYLTHPAFQKRKESITVTPSLQRERIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AL74</accession>
    <name>A0A061AL74_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F32B5.6</name>
        <name evidence="2 4" type="ORF">F32B5.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDR32797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293310.1">
        <property type="nucleotide sequence ID" value="NM_001306381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AL74"/>
    <dbReference type="GeneID" id="171827"/>
    <dbReference type="AGR" id="WB:WBGene00017979"/>
    <dbReference type="CTD" id="171827"/>
    <dbReference type="WormBase" id="F32B5.6i">
        <property type="protein sequence ID" value="CE30524"/>
        <property type="gene ID" value="WBGene00017979"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5785718at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017979">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AL74">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR32797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F32B5.6i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AL74"/>
        </source>
    </evidence>
    <sequence length="430" mass="48887" checksum="69A88C4F0A89CB40" modified="2014-09-03" version="1">MDDIAVPIASTSGEDSVISFQHPWTLKVCQRQIEDETILLNVSRPFSTSYKHVQFTWALRLTDEYVLSNNAAVDSNRHVLLHLYYKEGPCPEVAVEEVRAQILDPVTNETLFAGLALSPTEFSRGSGWPIHMEKERRAEFTELVHKKVDSNLLVVVEIKMKESLFEPLNYLPDVETAFRSQRIEKAVNKFVDDVINGKIRIPDLEHVDEKQADKFSVHRLIFIYGVDSVSREISDNEQQSEICEQLVRNTFAHIYFERVLSREITYFDDFVTLVEGLTFAHLPALRKEVERFICQKVIEADMDPSFAKKLLLVSEKYNLEILKMVINGFLVDQIIGNSNPPKELVNITHELQQMAHEIRENENIENLVGAVVTDLQELTRRVRRVSLSHSPSQSSHSSSPLATPTNGSGSPSVPAPFDSPTSRFKRVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AL77</accession>
    <name>A0A061AL77_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F23C8.13</name>
        <name evidence="2 4" type="ORF">F23C8.13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDR32802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293314.1">
        <property type="nucleotide sequence ID" value="NM_001306385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AL77"/>
    <dbReference type="GeneID" id="171799"/>
    <dbReference type="KEGG" id="cel:CELE_F23C8.13"/>
    <dbReference type="AGR" id="WB:WBGene00017741"/>
    <dbReference type="CTD" id="171799"/>
    <dbReference type="WormBase" id="F23C8.13b">
        <property type="protein sequence ID" value="CE30514"/>
        <property type="gene ID" value="WBGene00017741"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1138889_0_0_1"/>
    <dbReference type="OrthoDB" id="6022242at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017741">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AL77">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000403">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR32802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F23C8.13b"/>
        </source>
    </evidence>
    <sequence length="183" mass="21180" checksum="705264B8381E56EC" modified="2014-09-03" version="1">MAFRMVGSRSRGIFVDYIHPDSPQSTHLREGDRLLRCNKISLRAVSVDQAASIFRFWMSRSDSLTLLIERRSDGESVMMRRRRQARLSMCNEQREQTRHVVSGRATLRMTSSRSAEVFRCGDSTSFRMKSPKYESFNTSSPSKSICPQCNSQTRMIYLHQFSHGFVNNAFRFLIVSRSSYSLL</sequence>
</entry>
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    <accession>A0A061AL82</accession>
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        </submittedName>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32807.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="NP_001294013.1">
        <property type="nucleotide sequence ID" value="NM_001307084.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AL82"/>
    <dbReference type="GeneID" id="178263"/>
    <dbReference type="KEGG" id="cel:CELE_B0564.7"/>
    <dbReference type="AGR" id="WB:WBGene00007207"/>
    <dbReference type="CTD" id="178263"/>
    <dbReference type="WormBase" id="B0564.7b">
        <property type="protein sequence ID" value="CE49869"/>
        <property type="gene ID" value="WBGene00007207"/>
        <property type="gene designation" value="fask-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452163_0_0_1"/>
    <dbReference type="OrthoDB" id="5877528at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007207">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AL82">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR32807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="B0564.7b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AL82"/>
        </source>
    </evidence>
    <sequence length="179" mass="20382" checksum="DBA7F97865C23B1E" modified="2014-09-03" version="1">MTLLMISSAAKVDMQGKYEGPTVNKETFARFGINFDAKTIRNARQLKYSSNHSECDRYFLKSLFKLAPQDTHCQLPNVEDCGAFVDAYVMPDPNSNLLVNTSQWGSKKPRPLFFYGWLQTKQNTETSGEINTVGQEQLGLRLMRSAGFDPVVVFKTELDYCSTEIDQVNLLRDKIHKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AL87</accession>
    <name>A0A061AL87_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">KAP NTPase domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7 9" type="primary">kdin-1</name>
        <name evidence="7" type="ORF">CELE_F36H1.2</name>
        <name evidence="9" type="ORF">F36H1.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
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            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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    </dbReference>
    <dbReference type="SMR" id="A0A061AL87"/>
    <dbReference type="GeneID" id="178000"/>
    <dbReference type="AGR" id="WB:WBGene00006490"/>
    <dbReference type="CTD" id="178000"/>
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        <property type="protein sequence ID" value="CE49829"/>
        <property type="gene ID" value="WBGene00006490"/>
        <property type="gene designation" value="kdin-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001438_1_1_1"/>
    <dbReference type="OrthoDB" id="6084525at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006490">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KAP_P-loop"/>
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    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
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        <property type="entry name" value="SAM_KIDINS220"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23307">
        <property type="entry name" value="SAM_KIDINS220"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="514"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="5">
        <location>
            <begin position="464"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Kinase D-interacting substrate of 220 kDa-like SAM" evidence="6">
        <location>
            <begin position="1125"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1328"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1340"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1379"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDR32812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F36H1.2i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AL87"/>
        </source>
    </evidence>
    <sequence length="1436" mass="160110" checksum="1EEAC635030AA269" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AL89</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="8" type="ORF">CELE_R11A8.7</name>
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    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="gene ID" value="WBGene00011240"/>
        <property type="gene designation" value="mask-1"/>
    </dbReference>
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        <property type="component" value="Chromosome IV"/>
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    <dbReference type="Bgee" id="WBGene00011240">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        </location>
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        <source>
            <dbReference type="EMBL" id="CTQ86625.1"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARF3"/>
        </source>
    </evidence>
    <sequence length="967" mass="104181" checksum="E5FAF7998F142970" modified="2015-11-11" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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                <person name="Waterston R."/>
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        </source>
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        <property type="gene ID" value="WBGene00015409"/>
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            <dbReference type="EMBL" id="CTQ86432.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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            <dbReference type="WormBase" id="C03H5.7b"/>
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    <sequence length="269" mass="30934" checksum="118CBB5BDF5E1F33" modified="2015-11-11" version="1">MNFHISIHLVFSGLHALLVPIIAVEKNVMYIFTAVQFIPTNILQVLLAVYCGVFATTIVMRLVAGFYRWDNNLHPTLYYFESYLTFVYWITFALLVGIVCGWTVSYKMAQNSYVDSIIQAPIAKTFKLNLQNVTYVALFYTTEDGWNETGIKIGFTSLAVIVGSMLASYIFSFDIWAHYVQNIQERAPPAYDRGMFNNLISQIFISSMFSYLPVLTALLLPIFQLEGHVLYSQFSIFLASYSVISPISVIWNNRFYLYPVCTHLYRLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        </source>
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        </subcellularLocation>
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        <property type="gene ID" value="WBGene00001194"/>
        <property type="gene designation" value="egl-27"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="53"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
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        <location>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51156"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51293"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CTQ86442.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="C04A2.3n"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">Bristol N2</strain>
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        <property type="component" value="Chromosome IV"/>
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    </dbReference>
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    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Chromosome V"/>
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        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">Bristol N2</strain>
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        <source>
            <dbReference type="EMBL" id="SAP35577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C2S8</accession>
    <name>A0A2C9C2S8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Muscle M-line assembly protein unc-89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">unc-89</name>
        <name evidence="19" type="ORF">C09D1.1</name>
        <name evidence="17" type="ORF">CELE_C09D1.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Myofibril</location>
            <location evidence="8">Sarcomere</location>
            <location evidence="8">M line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SOF58704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343714.1">
        <property type="nucleotide sequence ID" value="NM_001356809.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2C9C2S8"/>
    <dbReference type="GeneID" id="171990"/>
    <dbReference type="AGR" id="WB:WBGene00006820"/>
    <dbReference type="CTD" id="171990"/>
    <dbReference type="WormBase" id="C09D1.1k">
        <property type="protein sequence ID" value="CE52154"/>
        <property type="gene ID" value="WBGene00006820"/>
        <property type="gene designation" value="unc-89"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006820">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C2S8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd20973">
        <property type="entry name" value="IgI_telokin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13325">
        <property type="entry name" value="PH_unc89"/>
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    </dbReference>
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        <property type="entry name" value="PK_Unc-89_rpt1"/>
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    </dbReference>
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        <property type="entry name" value="RhoGEF"/>
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        <property type="entry name" value="SH3 Domains"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="178"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SOF58779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="T24H10.7h"/>
        </source>
    </evidence>
    <sequence length="253" mass="27267" checksum="2E5161DA111955C3" modified="2017-12-20" version="1">MQTTNKYEFTGGAVSSPVLPVLQTAAFSPITPASASDMHTIVMSLLGNTPITSGPSIAPLSSPTLLPLVTSGDLDDLSMKILASSAIPGPPIISSSNSPDSSTTAVTTSQITAFQPLLNNFVSSTTASTSRPDKLNLTPPQQSAEIYAFNGVNSDDSDGGLDSRSASRCGMALDDQEKKKLERKRARNRQAATKCRQKKMDRIKELEEQVLHEKHRGQRLDAELLELNRALEHFRRTVEHHSGNGCPNNSIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C2W1</accession>
    <name>A0A2C9C2W1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">egl-44</name>
        <name evidence="10" type="ORF">CELE_F28B12.2</name>
        <name evidence="12" type="ORF">F28B12.2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343768.1">
        <property type="nucleotide sequence ID" value="NM_001356852.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C2W1"/>
    <dbReference type="SMR" id="A0A2C9C2W1"/>
    <dbReference type="GeneID" id="174005"/>
    <dbReference type="AGR" id="WB:WBGene00001208"/>
    <dbReference type="CTD" id="174005"/>
    <dbReference type="WormBase" id="F28B12.2j">
        <property type="protein sequence ID" value="CE52132"/>
        <property type="gene ID" value="WBGene00001208"/>
        <property type="gene designation" value="egl-44"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001208">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C2W1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.80:FF:000005">
        <property type="entry name" value="Transcription enhancer factor-like protein egl-44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016361">
        <property type="entry name" value="TEF_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002603">
        <property type="entry name" value="TEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="9">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="8">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SOF58760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="F28B12.2j"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C2W1"/>
        </source>
    </evidence>
    <sequence length="418" mass="46842" checksum="51DB19432A31B5BF" modified="2017-12-20" version="1">MAPESTSSLSDLSGDAEGVWSIDIDQAFQEALAIYPPCGRRKIIISDEGKMYGRNELIARYIKLRCGKTRTRKQVSSHIQVLARKKLRDEQAKKKVPFHLNTGDIPSLLQQASPPGGVKSPSAVVFPPVSAAVAAITEISPQSSYSSIVPKVETDQISQQLFKSLPLWSFQQTPGLPIGMDLSQLVFQQSSPDKTVSPVKSEVVEETKPIASSQLTLHSFSAYVKCNKTSLRTELVKIENTLEKDDIDISVFYEKYPKLLRELFEKSEKKDVFFLAKCWANINVSDDVQNCQYAVDSFYSSREKFQLKVSTMACSFGNQAVEKIEQYFPIEFDGSYSFILNNSPMCDYMVKFIAELKKLNVIETMNNVLENFTVLQIVTNSETDELLMVLCFVFEVSQEPEPSCSVYRLIDGGGDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C320</accession>
    <name>A0A2C9C320_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">ldh-1</name>
        <name evidence="12" type="ORF">CELE_F13D12.2</name>
        <name evidence="14" type="ORF">F13D12.2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 9"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343759.1">
        <property type="nucleotide sequence ID" value="NM_001356894.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C320"/>
    <dbReference type="SMR" id="A0A2C9C320"/>
    <dbReference type="GeneID" id="174798"/>
    <dbReference type="AGR" id="WB:WBGene00002262"/>
    <dbReference type="CTD" id="174798"/>
    <dbReference type="WormBase" id="F13D12.2b">
        <property type="protein sequence ID" value="CE52349"/>
        <property type="gene ID" value="WBGene00002262"/>
        <property type="gene designation" value="ldh-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5405561at2759"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002262">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C320">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05293">
        <property type="entry name" value="LDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000018">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000824">
        <property type="entry name" value="PRK00066.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
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        <location>
            <begin position="166"/>
            <end position="330"/>
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    <feature type="active site" description="Proton acceptor" evidence="7">
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            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="30"/>
            <end position="35"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
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            <position position="116"/>
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            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    <feature type="binding site" evidence="8">
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            <begin position="139"/>
            <end position="141"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00049258"/>
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            <dbReference type="Pfam" id="PF02866"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
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            <dbReference type="EMBL" id="SOF58751.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F13D12.2b"/>
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    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C320"/>
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    </evidence>
    <sequence length="336" mass="36385" checksum="0C70AF3C15DC7FFE" modified="2017-12-20" version="1">MTSMASTIKEVFAEIAAPVENSHGKVTVVGVGQVGMACAYSILQQNLANELCLVDVVADKLKGEMMDLQHGLAFTRHCTVKADTDYSITAGSKLCVVTAGARQREGETRLSLVQRNVEIFKGIIPQLVKYSPDTCILVVSNPVDVLTYVTWKLSGLPRERVFGSGTNLDSARFRFLLSEKLNIAPSSCHGWIIGEHGDSSVAVWSGVNVAGVTLHEIKPDIGEKTDNEHWEAEIHKKVVDSAYEIIKLKGYTSWAIGLSVAKIAQGIFSNSRNVFALSTNVKGFHGINDDVYLSLPVVLGSAGLTHVVKQQLTEAEVQKLHNSAKALLEVQNGIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C325</accession>
    <name>A0A2C9C325_CAEEL</name>
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        <submittedName>
            <fullName evidence="20">Ryanodine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">unc-68</name>
        <name evidence="20" type="ORF">CELE_K11C4.5</name>
        <name evidence="22" type="ORF">K11C4.5</name>
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    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="WBGene00006801"/>
        <property type="gene designation" value="unc-68"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300855at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
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        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
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    <dbReference type="GO" id="GO:0033017">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
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    <dbReference type="GO" id="GO:0006874">
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        <property type="entry name" value="Protein CBR-LIPL-6"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
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        <property type="entry name" value="Ins145_P3_rcpt"/>
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        <property type="entry name" value="Ion_trans_dom"/>
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        <property type="entry name" value="MIR_motif"/>
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        <property type="entry name" value="RIH_dom"/>
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    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
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    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
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    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
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    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
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    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
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        <property type="entry name" value="SPRY1_RyR"/>
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    <dbReference type="PANTHER" id="PTHR46399">
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    </dbReference>
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        <property type="entry name" value="RR_TM4-6"/>
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        <property type="entry name" value="RYANODINER"/>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4434"/>
            <end position="4457"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4620"/>
            <end position="4637"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4683"/>
            <end position="4705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4821"/>
            <end position="4843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4863"/>
            <end position="4888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4948"/>
            <end position="4967"/>
        </location>
    </feature>
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        <location>
            <begin position="102"/>
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        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="580"/>
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        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="1004"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="1475"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="4180"/>
            <end position="4215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
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            <dbReference type="PROSITE" id="PS50188"/>
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            <dbReference type="PROSITE" id="PS50222"/>
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            <dbReference type="PROSITE" id="PS50919"/>
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            <dbReference type="EMBL" id="SOF58813.1"/>
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            <dbReference type="PeptideAtlas" id="A0A2C9C325"/>
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    <sequence length="5069" mass="576299" checksum="972A1E597B574BA2" modified="2017-12-20" version="1"> </sequence>
</entry>
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    <accession>A0A2C9C326</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="SOF58852.1"/>
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        <source>
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            <dbReference type="PeptideAtlas" id="A0A2C9C326"/>
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    </evidence>
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</entry>
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    <accession>A0A2C9C327</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
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    <dbReference type="PANTHER" id="PTHR37972:SF2">
        <property type="entry name" value="PRION-LIKE-(Q_N-RICH)-DOMAIN-BEARING PROTEIN-RELATED"/>
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    </dbReference>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="160" mass="18922" checksum="EC0E76EBD0EAD665" modified="2017-12-20" version="1">MDFGGRPPPPMDDTYFPSLLKKDIWSQIENNTINFPADIRGWLKKLTDEKDLIDNYSLEKQPAINQWFAETDFVIRTLRCVNLPELVEHYEDQLTAQKIYLEKIDHRSGILKYLIERLEMAVAEEENKIDKQVDIEKEETTIVMQIQHSKKNKKKSKNKK</sequence>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="SOF58761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F28B12.2k"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C333"/>
        </source>
    </evidence>
    <sequence length="428" mass="47548" checksum="7854694FD3E3F35D" modified="2017-12-20" version="1">MMTLSPPAGDGPGSAGSMAPESTSSLSDLSGDAEGVWSIDIDQAFQEALAIYPPCGRRKIIISDEGKMYGRNELIARYIKLRCGKTRTRKQVSSHIQVLARKKLRDEQAKKKGDIPSLLQQASPPGGVKSPSAVVFPPVSAAVAAITEISPQSSYSSIVPKVETDQISQQLFKSLPLWSFQQTPGLPIGMDLSQLVFQQSSPDKTVSPVKSEVVEETKPIASSQLTLHSFSAYVKCNKTSLRTELVKIENTLEKDDIDISVFYEKYPKLLRELFEKSEKKDVFFLAKCWANINVSDDVQNCQYAVDSFYSSREKFQLKVSTMACSFGNQAVEKIEQYFPIEFDGSYSFILNNSPMCDYMVKFIAELKKLNVIETMNNVLENFTVLQIVTNSETDELLMVLCFVFEVSQEPEPSCSVYRLIDGGGDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C336</accession>
    <name>A0A2C9C336_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Glycoprotein</fullName>
        </submittedName>
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        <name evidence="3 5" type="ORF">C35A11.3</name>
        <name evidence="3" type="ORF">CELE_C35A11.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343825.1">
        <property type="nucleotide sequence ID" value="NM_001356641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C336"/>
    <dbReference type="GeneID" id="183228"/>
    <dbReference type="AGR" id="WB:WBGene00016430"/>
    <dbReference type="CTD" id="183228"/>
    <dbReference type="WormBase" id="C35A11.3b">
        <property type="protein sequence ID" value="CE52397"/>
        <property type="gene ID" value="WBGene00016430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016430">
        <property type="expression patterns" value="Expressed in adult organism"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013401755" evidence="2">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SOF58823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C35A11.3b"/>
        </source>
    </evidence>
    <sequence length="247" mass="27382" checksum="D2875BD0504B3677" modified="2017-12-20" version="1">MTSIHLLLLLTMCTPVAETNYQPSDPAPFDTFCTRETSTTTATESTTVSTPTTATSSTPELSSSNSPSTETTTCASPTTSTNGHLTSTTDGAATSPIKTETPKHQICFTPNQATFSRNSTLIQGTCITKPFTGYAMAIRRQDDLEERDYSKILTFKPIVFYEKANETGPHLYLENHRGLNVIFVFYNNKKNVVILDASQKNNCANDKADCLPFEYRDINAFIYHICWDRDTHADGNFIDALLEKMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C338</accession>
    <name>A0A2C9C338_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_EGAP1.5</name>
        <name evidence="1 3" type="ORF">EGAP1.5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SOF58786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C338"/>
    <dbReference type="AGR" id="WB:WBGene00271775"/>
    <dbReference type="WormBase" id="EGAP1.5a">
        <property type="protein sequence ID" value="CE52379"/>
        <property type="gene ID" value="WBGene00271775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00271775">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C338">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SOF58786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="EGAP1.5a"/>
        </source>
    </evidence>
    <sequence length="99" mass="11723" checksum="5F3099798AAD5C0D" modified="2017-12-20" version="1">MDVKSDGTYFLRVFDCTVVLKEIRLVKRRAQLTDDLPHQDVHISVFPSFVLFFHQVHPFLLIQPFFACFSMRLIMIRSLTDYLHLSSSHIFEGIWSETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C343</accession>
    <name>A0A2C9C343_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_H43E16.1</name>
        <name evidence="3 5" type="ORF">H43E16.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C343"/>
    <dbReference type="SMR" id="A0A2C9C343"/>
    <dbReference type="AGR" id="WB:WBGene00019273"/>
    <dbReference type="WormBase" id="H43E16.1b">
        <property type="protein sequence ID" value="CE52232"/>
        <property type="gene ID" value="WBGene00019273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019273">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C343">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37972:SF2">
        <property type="entry name" value="PRION-LIKE-(Q_N-RICH)-DOMAIN-BEARING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37972">
        <property type="entry name" value="PROTEIN CBG25533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SOF58766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="H43E16.1b"/>
        </source>
    </evidence>
    <sequence length="929" mass="93856" checksum="5837B643D0888678" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C344</accession>
    <name>A0A2C9C344_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T05B9.2</name>
        <name evidence="2 4" type="ORF">T05B9.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C344"/>
    <dbReference type="SMR" id="A0A2C9C344"/>
    <dbReference type="AGR" id="WB:WBGene00011465"/>
    <dbReference type="WormBase" id="T05B9.2d">
        <property type="protein sequence ID" value="CE52373"/>
        <property type="gene ID" value="WBGene00011465"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5782698at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011465">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C344">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T05B9.2d"/>
        </source>
    </evidence>
    <sequence length="176" mass="20527" checksum="C15FD7CAED5396AF" modified="2017-12-20" version="1">MSIEGGNYRRIRNFVDRECAKECIEDFSCFGYEWNSEEKICYLKSRSTSGKLIAKPNTMVGFCQDDDEVRYRLQDHVIVGPIVMEADDVPDGEECKENCRKVGALYYSWRPNSDNQRSNVVPVEEEEDDEEQEVLGHCECISTMNELRLEYDAFSGFIPIPKHKHRRSILLRPFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C345</accession>
    <name>A0A2C9C345_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T05C12.11</name>
        <name evidence="2 4" type="ORF">T05C12.11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C345"/>
    <dbReference type="AGR" id="WB:WBGene00011473"/>
    <dbReference type="WormBase" id="T05C12.11a">
        <property type="protein sequence ID" value="CE52317"/>
        <property type="gene ID" value="WBGene00011473"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799308at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011473">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C345">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T05C12.11a"/>
        </source>
    </evidence>
    <sequence length="287" mass="32431" checksum="057D20284F8D773F" modified="2017-12-20" version="1">MIILILLLFNVVLSKLIRVNEWHDIPVKGTEDEDALIDFHLFATCEKFSVLFMTEPNESTRFEFSYYDVTLKKIDVQSIGNAVQVPVSPKMLGTCRENNRKILRIKIRTSNDTITFKVDDQIIRRPFDSTQNNIKILIPQKVACCLIRALFLNNSDLDAYTSVSTRFFTSSKSSYKRILEVFGSTSSSLVLTTTPSTSTSRTTTKNDTNKWSKFTLGKNPTVSSSTSEPKMESSWTHAVNKEWSITFVLCSVIVCTIMLFLAVFGTFTVFYLMTKPRGGKSPFAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C346</accession>
    <name>A0A2C9C346_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-CAP/cofactor C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C54G6.2</name>
        <name evidence="3" type="ORF">CELE_C54G6.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SOF58713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343722.1">
        <property type="nucleotide sequence ID" value="NM_001356796.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C346"/>
    <dbReference type="SMR" id="A0A2C9C346"/>
    <dbReference type="GeneID" id="183814"/>
    <dbReference type="KEGG" id="cel:CELE_C54G6.2"/>
    <dbReference type="AGR" id="WB:WBGene00016931"/>
    <dbReference type="CTD" id="183814"/>
    <dbReference type="WormBase" id="C54G6.2b">
        <property type="protein sequence ID" value="CE52148"/>
        <property type="gene ID" value="WBGene00016931"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016931">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C346">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039589">
        <property type="entry name" value="TBCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052:SF0">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SOF58713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C54G6.2b"/>
        </source>
    </evidence>
    <sequence length="178" mass="20371" checksum="09B5864172BEB36E" modified="2017-12-20" version="1">MYTKWIVLGAVRGIVIVKNCQSTRISVSCDQLIVLDSKNIEIYAMSPKKPIIFNSSAVTFAPFNTIYEGQMEFLEENGHGLEHNLVLKEPINFGDGSWKLMETSRFVCQHTPLHTSDKQFEMLLNSLPEEYRVAHHRNAQDAQKMISLDPEKCRLTDVTSNFDLLFLKSKIEKIHVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C351</accession>
    <name>A0A2C9C351_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_E02A10.3</name>
        <name evidence="7 9" type="ORF">E02A10.3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the troponin C family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C351"/>
    <dbReference type="SMR" id="A0A2C9C351"/>
    <dbReference type="AGR" id="WB:WBGene00008453"/>
    <dbReference type="WormBase" id="E02A10.3f">
        <property type="protein sequence ID" value="CE52076"/>
        <property type="gene ID" value="WBGene00008453"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008453">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C351">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000336">
        <property type="entry name" value="HLH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000355">
        <property type="entry name" value="Uncharacterized calcium-binding protein B0563.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF46">
        <property type="entry name" value="TROPONIN C-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SOF58833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="E02A10.3f"/>
        </source>
    </evidence>
    <sequence length="195" mass="22568" checksum="CFE6064F72F4EE20" modified="2017-12-20" version="1">MHVFMLSIRDSTKLLKLHSDRGDGNSPHGIADPLLSQHLLEGYSEEELQEYRQVFNMFDADRSGAIAIDELEAAIKNLGLEQTRDELDKIIDEVDQRGNHQIDFDEFCVVMRRLTMKKSNWNEVVKECFTVFDRSENGGISKKDFRFILRELGDITDNQIIDEIFNEADVDGNGVIDYDEFTYMVKNYMTDDDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C352</accession>
    <name>A0A2C9C352_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dynamin-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">rme-1</name>
        <name evidence="15" type="ORF">CELE_W06H8.1</name>
        <name evidence="17" type="ORF">W06H8.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343867.1">
        <property type="nucleotide sequence ID" value="NM_001356659.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C352"/>
    <dbReference type="SMR" id="A0A2C9C352"/>
    <dbReference type="GeneID" id="179010"/>
    <dbReference type="AGR" id="WB:WBGene00004373"/>
    <dbReference type="CTD" id="179010"/>
    <dbReference type="WormBase" id="W06H8.1i">
        <property type="protein sequence ID" value="CE52305"/>
        <property type="gene ID" value="WBGene00004373"/>
        <property type="gene designation" value="rme-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004373">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C352">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="55"/>
            <end position="286"/>
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        <location>
            <begin position="490"/>
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            <begin position="401"/>
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            <begin position="534"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C352"/>
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    <sequence length="560" mass="63346" checksum="EE05C6906624CE7F" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C354</accession>
    <name>A0A2C9C354_CAEEL</name>
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        <submittedName>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="20 21">Bristol N2</strain>
        </source>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
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    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <end position="155"/>
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            <end position="423"/>
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        <location>
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            <end position="601"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SOF58745.1"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C380"/>
        </source>
    </evidence>
    <sequence length="661" mass="71489" checksum="A92A2FAEC52CF39C" modified="2017-12-20" version="1"> </sequence>
</entry>
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    <accession>A0A5E4LWD8</accession>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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            <strain evidence="4 5">Bristol N2</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VVC12346.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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            <dbReference type="PeptideAtlas" id="A0A5E4LWD8"/>
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    </evidence>
    <sequence length="498" mass="57551" checksum="E64A6DE22BF66973" modified="2019-11-13" version="1">METLGRVWNRLSIRRPTLATPEPVEEEDDMTPEKTKEVFQMFKGAPTRRKSENAHSHRVVLNQLQNHPPRNATQSPQRQPRTSESSMDFPRSALRRNSTDTHVFANRTHNHRDINVPACSSEEDRVSTARRNSLFVKRGSVTMEPIKKVDLEEVYTVNKQLGTGRFGFIKLAEHKQSKQRIAIKFFPRPQTKQADFVREYNYSFFLSPHQNIIDTYEGMFQSSDDTAYFFVQEFCPRASLREAVEATNQAGIGEANTKKVFAAVLSAIEFMHDENLVHRNLKAENILIFDANDYSKVKVTDFGLTRKVDTTVKYLEYVNNYHAAELCDTVVNEKLVVNKSTDIWALGIIFFYCMKGKFPWQKASIMCKPYWEWEQWLKRKNPALPKKFNPFSEKALKLFKKSLTPRFKDRWTAKDMRKCLAKEKLLKSVKRPEEDYYVMIDTASKSRQTATSSSGEPQDPSAPAAEQRKQKSTLQQWISTTLTAMAEISEQVVSARDD</sequence>
</entry>
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    <accession>A0A5E4LWF5</accession>
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        <name evidence="2 4" type="ORF">H11E01.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VVC12356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A5E4LWF5"/>
    <dbReference type="AGR" id="WB:WBGene00019188"/>
    <dbReference type="WormBase" id="H11E01.3b">
        <property type="protein sequence ID" value="CE53634"/>
        <property type="gene ID" value="WBGene00019188"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5838632at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A5E4LWF5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027962">
        <property type="entry name" value="ERICH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23034">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23034:SF2">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="293"/>
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    </feature>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">Bristol N2</strain>
        </source>
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        <reaction evidence="7">
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
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        </reaction>
    </comment>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000021">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF10">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YrdC-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAN86632.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y48C3A.18b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="A5HWA9"/>
        </source>
    </evidence>
    <sequence length="143" mass="15311" checksum="CD56831AD82EE408" modified="2009-02-10" version="2">MKLVSRQTISDELANCLLPGPVTLMFERLPCLPAEFNPGVVNVACRVPDCPIVSTICKKLGQPLAQTSANVSGSSLNPTSIDHFRDLHPNIDLILDAGSIISSGEGSTIVDLTVESGFRIVRSGCAEKETMQKLKSFGLTKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-06-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A5HWB0</accession>
    <name>A5HWB0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PXA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">snx-13</name>
        <name evidence="3" type="ORF">CELE_Y116A8C.26</name>
        <name evidence="5" type="ORF">Y116A8C.26</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAN86917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359711.1">
        <property type="nucleotide sequence ID" value="NM_001372974.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A5HWB0"/>
    <dbReference type="SMR" id="A5HWB0"/>
    <dbReference type="GeneID" id="178482"/>
    <dbReference type="UCSC" id="Y116A8C.26a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013803"/>
    <dbReference type="CTD" id="178482"/>
    <dbReference type="WormBase" id="Y116A8C.26b">
        <property type="protein sequence ID" value="CE41041"/>
        <property type="gene ID" value="WBGene00013803"/>
        <property type="gene designation" value="snx-13"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124216_0_0_1"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013803">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A5HWB0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="2">
        <location>
            <begin position="94"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAN86917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y116A8C.26b"/>
        </source>
    </evidence>
    <sequence length="148" mass="16697" checksum="505EE2EB76575989" modified="2007-06-26" version="1">MSNRLYILLAVVLFLATFGSTGLIVLPASILCFVAGFLYIFYQTGHEKHDEIAGILSENLQKGKLSAGIEALLKNGKRLKEQNQYVEVHSMCNSPQLDLVLEQILGNITRDYVGFWYKTLSNDNIFEQSLKRTSRRSIASLTQWCVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-06-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A5HWB1</accession>
    <name>A5HWB1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">ntl-11</name>
        <name evidence="2" type="ORF">CELE_Y73F8A.25</name>
        <name evidence="4" type="ORF">Y73F8A.25</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAN86919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001122830.1">
        <property type="nucleotide sequence ID" value="NM_001129358.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A5HWB1"/>
    <dbReference type="PeptideAtlas" id="A5HWB1"/>
    <dbReference type="GeneID" id="178432"/>
    <dbReference type="KEGG" id="cel:CELE_Y73F8A.25"/>
    <dbReference type="UCSC" id="Y73F8A.25b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013530"/>
    <dbReference type="CTD" id="178432"/>
    <dbReference type="WormBase" id="Y73F8A.25c">
        <property type="protein sequence ID" value="CE41081"/>
        <property type="gene ID" value="WBGene00013530"/>
        <property type="gene designation" value="ntl-11"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3052347_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013530">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A5HWB1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAN86919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y73F8A.25c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A5HWB1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7467" checksum="144F41386A9CCEEF" modified="2007-06-26" version="1">MTKKKAKKNQKTGAAAAPPHESQKKEKENDFEMLEDIKRDEDLFFSETDISNISKYFFLLRISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>B3WFU2</accession>
    <name>B3WFU2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nhr-137</name>
        <name evidence="8" type="ORF">C56E10.4</name>
        <name evidence="6" type="ORF">CELE_C56E10.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD65639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041235.1">
        <property type="nucleotide sequence ID" value="NM_001047770.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3WFU2"/>
    <dbReference type="SMR" id="B3WFU2"/>
    <dbReference type="GeneID" id="183865"/>
    <dbReference type="AGR" id="WB:WBGene00003727"/>
    <dbReference type="CTD" id="183865"/>
    <dbReference type="WormBase" id="C56E10.4c">
        <property type="protein sequence ID" value="CE39711"/>
        <property type="gene ID" value="WBGene00003727"/>
        <property type="gene designation" value="nhr-137"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052085_0_0_1"/>
    <dbReference type="OrthoDB" id="5828275at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003727">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFU2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000114">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45886:SF14">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45886">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="65"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD65639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="C56E10.4c"/>
        </source>
    </evidence>
    <sequence length="296" mass="33498" checksum="80BE55ADA1061545" modified="2008-09-02" version="1">MRKEAVTSGIVGNEEKVAPQTAYLASISLPSTSTAIPKVTETASCLRQTLRLITKFRKCNIIVEKIDLHISALLTMPSFLDNLNNYQEETDFKRDLPEWCTIDLLCAIEFAKKLPDLSKFSDSDKEELIRNSCFTIAIAIEAIESYFDKKKTVVMPDGTDVMQSLANSGSVIHAVFTQMFVCILDPLHRESFTIDELVLTLQLLFFTIAAPENLTPEGKEQLEKSVKSSMHCLMVLLITQNTTNFSARYGSLIALNETFIKTAHAHKQKMKEAEHSRQKFRDFLIEQCVFDYRPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>B3WFV4</accession>
    <name>B3WFV4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">lars-2</name>
        <name evidence="10" type="ORF">CELE_ZK524.3</name>
        <name evidence="12" type="ORF">ZK524.3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAQ76503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129803.1">
        <property type="nucleotide sequence ID" value="NM_001136331.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3WFV4"/>
    <dbReference type="SMR" id="B3WFV4"/>
    <dbReference type="PeptideAtlas" id="B3WFV4"/>
    <dbReference type="GeneID" id="172499"/>
    <dbReference type="AGR" id="WB:WBGene00003074"/>
    <dbReference type="CTD" id="172499"/>
    <dbReference type="WormBase" id="ZK524.3c">
        <property type="protein sequence ID" value="CE42742"/>
        <property type="gene ID" value="WBGene00003074"/>
        <property type="gene designation" value="lars-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_1"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003074">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFV4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="9">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAQ76503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="ZK524.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="B3WFV4"/>
        </source>
    </evidence>
    <sequence length="455" mass="51389" checksum="ACD57982EDB89B90" modified="2008-09-02" version="1">MIQTKDGKRVAVQLNKLPVLGSDRGQEVDKERFGESGVFDTDTLDTFFDSAWYYLRYLDNKNKSELISKGAMKNMPVDVYVGGIEHAAVHMFFARFVAYFLKDINVIQTAEPFTDLIPQGIVRGKTFIEKETGKYLGSEDVQQSGDKLTLKNDSSVEVDAVYEKMSKSKNNGVDLAAILDSEGVDMTRLRLLEAAAPRAPINWGETDLKGIKKLLDRIAAINSQIVDARDNGKPIELKKEIDGSIKETYNFFVRNVGMCLEVLHLHNTALMRIQGFTNALKKVDPIYLAHSPEGQRAVKSLIIMLQVFCPHVASEMWSALANDGSLVSDQKWPEVDKDADIEFLLMIDGVSGGRPSLDRRIIEEMSMDQLWERATFYEHADILRMMKEDGMKLKNSSYISRKGFHVTLSCSLEGDKEENRKKIGKILDRIQAEKRKLEIGKKGGKRKKEKKIVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>B3WFZ4</accession>
    <name>B3WFZ4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BAAT/Acyl-CoA thioester hydrolase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="ORF">C31H5.6</name>
        <name evidence="5" type="ORF">CELE_C31H5.6</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAQ76461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129757.1">
        <property type="nucleotide sequence ID" value="NM_001136285.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3WFZ4"/>
    <dbReference type="SMR" id="B3WFZ4"/>
    <dbReference type="ESTHER" id="caeel-C31H5.6">
        <property type="family name" value="Acyl-CoA_Thioesterase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.B10"/>
    <dbReference type="PeptideAtlas" id="B3WFZ4"/>
    <dbReference type="GeneID" id="172725"/>
    <dbReference type="KEGG" id="cel:CELE_C31H5.6"/>
    <dbReference type="AGR" id="WB:WBGene00007857"/>
    <dbReference type="CTD" id="172725"/>
    <dbReference type="WormBase" id="C31H5.6b">
        <property type="protein sequence ID" value="CE42779"/>
        <property type="gene ID" value="WBGene00007857"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029849_4_0_1"/>
    <dbReference type="OrthoDB" id="6347013at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007857">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFZ4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000739">
        <property type="entry name" value="Protein CBG14567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006862">
        <property type="entry name" value="Thio_Ohase/aa_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF11">
        <property type="entry name" value="BAAT_ACYL-COA THIOESTER HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04775">
        <property type="entry name" value="Bile_Hydr_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="4">
        <location>
            <begin position="124"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR016521-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAQ76461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C31H5.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="B3WFZ4"/>
        </source>
    </evidence>
    <sequence length="358" mass="40436" checksum="9867716F239D056F" modified="2008-09-02" version="1">MGLFLSMTPSEDFAYGGYLRCTPPIPFFYLLQLSDDSGTKLDEMYIKKHWMHPLLTRTEIEYDGFCGTLFKPPGDGPFPCVMDISGTGGGLHEHKGAMLASEGFVVICVAFFQFKDLPYKLEDVDVEYFLKPIEFVLGLSYTTNMLGIQGVSFGATIVDLLSTRYPQIKAVVSINGPHAQCSYSLLKEHGKQMIVPELDDSKLYFLNTILVTAPCFKTLTPILTEENSIPWHWIPKETAFRLIGSVDDLCAPSIHSNLHIQKKLQETGHYVELELVNGGHIMEPPYFPHHDIVYAKFQGFYCGYGGEIVLHAKSQERTWANTINFFKRKLGSPPPMPDWTRLFIVNAPLKPIENRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFI4</accession>
    <name>D7SFI4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nas-4</name>
        <name evidence="15" type="ORF">C05D11.6</name>
        <name evidence="13" type="ORF">CELE_C05D11.6</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370381.1">
        <property type="nucleotide sequence ID" value="NM_001382895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFI4"/>
    <dbReference type="SMR" id="D7SFI4"/>
    <dbReference type="MEROPS" id="M12.A19"/>
    <dbReference type="GeneID" id="182259"/>
    <dbReference type="AGR" id="WB:WBGene00003523"/>
    <dbReference type="CTD" id="182259"/>
    <dbReference type="WormBase" id="C05D11.6c">
        <property type="protein sequence ID" value="CE44965"/>
        <property type="gene ID" value="WBGene00003523"/>
        <property type="gene designation" value="nas-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003523">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFI4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF818">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005127038" description="Metalloendopeptidase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="95"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD63206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="C05D11.6c"/>
        </source>
    </evidence>
    <sequence length="352" mass="40286" checksum="8376C63181738418" modified="2010-08-10" version="1">MMTIQRYSLVFCAIFATCWTASVVNNKQVIDTSVPQTETTLNDADFHSDLHQRYDLQTLGIKVKDDPTIGNYSEGDILLESPKKFVEENNKLGRNAIKQIYRRWPNNEIPYTLSSQYGSYARSVIANAMNEYHTKTCVKFVARDPSKHHDYLWIHPDEGCYSLVGKTGGKQPVSLDSGCIQVGTIVHELMHAVGFFHEQSRQDRDSYIDVVWQNVMNGADDQFEKYNLNVISHLDEPYDYASIMHYGPYAFSGSGKKTLVPKKSGSERMGQRVKFSDIDVRKINKLYNCPGVSGNNNNNNNNQINSNSIVNHPQTEPCEDLTWRCRFWSLFSYCQRREVRAIICRKSCSVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFI5</accession>
    <name>D7SFI5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nas-4</name>
        <name evidence="15" type="ORF">C05D11.6</name>
        <name evidence="13" type="ORF">CELE_C05D11.6</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD63205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254938.1">
        <property type="nucleotide sequence ID" value="NM_001268009.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFI5"/>
    <dbReference type="SMR" id="D7SFI5"/>
    <dbReference type="MEROPS" id="M12.A19"/>
    <dbReference type="GeneID" id="182259"/>
    <dbReference type="AGR" id="WB:WBGene00003523"/>
    <dbReference type="CTD" id="182259"/>
    <dbReference type="WormBase" id="C05D11.6b">
        <property type="protein sequence ID" value="CE44904"/>
        <property type="gene ID" value="WBGene00003523"/>
        <property type="gene designation" value="nas-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017286_0_0_1"/>
    <dbReference type="OMA" id="VERCEDF"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="PhylomeDB" id="D7SFI5"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003523">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFI5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF818">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005127057" description="Metalloendopeptidase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="95"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD63205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="C05D11.6b"/>
        </source>
    </evidence>
    <sequence length="365" mass="41662" checksum="9265ECA4045D86E8" modified="2010-08-10" version="1">MMTIQRYSLVFCAIFATCWTASVVNNKQVIDTSVPQTETTLNDADFHSDLHQRYDLQTLGIKVKDDPTIGNYSEGDILLESPKKFVEENNKLGRNAIKQIYRRWPNNEIPYTLSSQYGSYARSVIANAMNEYHTKTCVKFVARDPSKHHDYLWIHPDEGCYSLVGKTGGKQPVSLDSGCIQVGTIVHELMHAVGFFHEQSRQDRDSYIDVVWQNVMNGADDQFEKYNLNVISHLDEPYDYASIMHYGPYAFSGSGKKTLVPKKSGSERMGQRVKFSDIDVRKINKLYNCPGVSGNNNNNNNNQINSNSIVNHPQSRYAGLPLSTSNQTEPCEDLTWRCRFWSLFSYCQRREVRAIICRKSCSVCK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>G5EGN8-2</accession>
    <name>NHR27_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Nuclear hormone receptor family member nhr-27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nhr-27</name>
        <name evidence="4" type="ORF">F16H9.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2013" name="Aging (Albany NY)" volume="5" first="741" last="758">
            <title>TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants.</title>
            <authorList>
                <person name="Khan M.H."/>
                <person name="Ligon M."/>
                <person name="Hussey L.R."/>
                <person name="Hufnal B."/>
                <person name="Farber R. II"/>
                <person name="Munkacsy E."/>
                <person name="Rodriguez A."/>
                <person name="Dillow A."/>
                <person name="Kahlig E."/>
                <person name="Rea S.L."/>
            </authorList>
            <dbReference type="PubMed" id="24107417"/>
            <dbReference type="DOI" id="10.18632/aging.100604"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G5EGN8-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G5EGN8-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_061416"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001366722.1">
        <property type="nucleotide sequence ID" value="NM_001381126.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F16H9.2a">
        <property type="protein sequence ID" value="CE05645"/>
        <property type="gene ID" value="WBGene00008901"/>
        <property type="gene designation" value="nhr-27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F16H9.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F16H9.2b"/>
        </source>
    </evidence>
    <sequence length="334" mass="38706" checksum="BEA6C710B6DF5B4B" modified="2011-12-14" version="1">MSTYVSNCVVCGRLTSLFNYGAHSCSACGSFLRRTLASSKFLDDCKYSGNCFENFKRAIHFECKFCRLHKCVQKGMLDLSRYTHLERLICELSEFDSKRETLFLTMTVSNGFKAEELMWQSSVSLVKKPPHLVFNSHDWGFMNQVTIIDFLKKLEFSKFLSSQDLRSFLKCTHFTQVILKSAVISYNANQNYMSFPNKIDIFPETVTEGTSISVNLQNRIRCRLVNRLIELKVTHEEMLLLCAIAFSNPAIPELSENGRTLLNSYQNVYRSALFQYCSTAYQRNGPSRFNDLLFLLHVVTKTHDDIKKYFTLFQFFQPTEQPSQVHQDVIEFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>I7KSC2</accession>
    <name>I7KSC2_CAEEL</name>
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        <submittedName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor subunit 6</fullName>
        </submittedName>
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    <gene>
        <name evidence="6 8" type="primary">cfim-2</name>
        <name evidence="6" type="ORF">CELE_D1046.1</name>
        <name evidence="8" type="ORF">D1046.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCJ09398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368144.1">
        <property type="nucleotide sequence ID" value="NM_001380392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I7KSC2"/>
    <dbReference type="SMR" id="I7KSC2"/>
    <dbReference type="PeptideAtlas" id="I7KSC2"/>
    <dbReference type="GeneID" id="177710"/>
    <dbReference type="AGR" id="WB:WBGene00008362"/>
    <dbReference type="CTD" id="177710"/>
    <dbReference type="WormBase" id="D1046.1e">
        <property type="protein sequence ID" value="CE47724"/>
        <property type="gene ID" value="WBGene00008362"/>
        <property type="gene designation" value="cfim-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025289_1_0_1"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008362">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="I7KSC2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057951">
        <property type="entry name" value="CPSF6/7_RSLD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25524">
        <property type="entry name" value="RSLD_CPSF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSF6/7 RSLD" evidence="5">
        <location>
            <begin position="178"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCJ09398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="D1046.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="I7KSC2"/>
        </source>
    </evidence>
    <sequence length="293" mass="32505" checksum="552BB0F61BBA169B" modified="2012-10-03" version="1">MGTIRIGAGGQTGRTGTSVSGRSGPPPLMMQQVRPTPLMSQPTSLPSNLNQAPQMRLQINGQQVPLMNRAPVPQQTMLGNGPLGGMNQQIQQQPQMMMGQQVRPMMQTSMGIQPMMGMNAPPPMNNQFQNRPPQLGSMGVQPLMQMNTAMRPPINGLPPVHVNPQMFPGLQGTVLSDAEFEDVMTRNQTVSSSAIARAITDASVGDIKGASETILTAIQLIKNSRIGHDERCRQLVYGLEHTLKGLESKGYSSRSKSHRDRSRSRERDRKRRRRSRTRSRSYSRSPSPRRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>O17350</accession>
    <name>O17350_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gag-pol polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F52D1.2</name>
        <name evidence="2 4" type="ORF">F52D1.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD70825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T32447">
        <property type="entry name" value="T32447"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508103.2">
        <property type="nucleotide sequence ID" value="NM_075702.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O17350"/>
    <dbReference type="GeneID" id="186101"/>
    <dbReference type="UCSC" id="F52D1.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00018683"/>
    <dbReference type="CTD" id="186101"/>
    <dbReference type="WormBase" id="F52D1.2a">
        <property type="protein sequence ID" value="CE35717"/>
        <property type="gene ID" value="WBGene00018683"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1604228_0_0_1"/>
    <dbReference type="OrthoDB" id="10414678at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018683">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O17350">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD70825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F52D1.2a"/>
        </source>
    </evidence>
    <sequence length="166" mass="18929" checksum="C77792C78BC826F4" modified="2004-03-01" version="2">MTNSGKMPKKKTMFKKIGSFLKMRQNEEDRFSGKSLFSIENENHIEYASVSNEDYDMNPAMDLIHEDLARASLLTDFNTKIDEFEHGFVNLGYVEKMNNTTKSKNLSGDFQRPRLSRQNAVVQERDSNSAMEKIKTKSCDTETSPVAKSPSSNMSSAKEERIIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2025-10-08" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>O17351</accession>
    <name>O17351_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activated in Blocked Unfolded protein response</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">abu-12</name>
        <name evidence="3" type="ORF">CELE_F52D1.3</name>
        <name evidence="5" type="ORF">F52D1.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD70826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T32448">
        <property type="entry name" value="T32448"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508104.2">
        <property type="nucleotide sequence ID" value="NM_075703.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O17351"/>
    <dbReference type="SMR" id="O17351"/>
    <dbReference type="PaxDb" id="6239-F52D1.3"/>
    <dbReference type="PeptideAtlas" id="O17351"/>
    <dbReference type="GeneID" id="180399"/>
    <dbReference type="UCSC" id="F52D1.3">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004127"/>
    <dbReference type="CTD" id="180399"/>
    <dbReference type="WormBase" id="F52D1.3a">
        <property type="protein sequence ID" value="CE37115"/>
        <property type="gene ID" value="WBGene00004127"/>
        <property type="gene designation" value="abu-12"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SBB1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_341710_0_0_1"/>
    <dbReference type="OMA" id="PRQIRIQ"/>
    <dbReference type="OrthoDB" id="5868029at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004127">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O17351">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004157374" evidence="2">
        <location>
            <begin position="20"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD70826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F52D1.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="O17351"/>
        </source>
    </evidence>
    <sequence length="774" mass="84811" checksum="C62BE175B2634E62" modified="2004-09-13" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>O17363</accession>
    <name>O17363_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Seven TM Receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">str-20</name>
        <name evidence="4" type="ORF">C05E4.2</name>
        <name evidence="2" type="ORF">CELE_C05E4.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD63234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B88940">
        <property type="entry name" value="B88940"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_503316.1">
        <property type="nucleotide sequence ID" value="NM_070915.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O17363"/>
    <dbReference type="SMR" id="O17363"/>
    <dbReference type="PaxDb" id="6239-C05E4.2"/>
    <dbReference type="GeneID" id="191970"/>
    <dbReference type="UCSC" id="C05E4.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006087"/>
    <dbReference type="CTD" id="191970"/>
    <dbReference type="WormBase" id="C05E4.2a">
        <property type="protein sequence ID" value="CE25757"/>
        <property type="gene ID" value="WBGene00006087"/>
        <property type="gene designation" value="str-20"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TGGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036335_4_1_1"/>
    <dbReference type="OrthoDB" id="5819992at2759"/>
    <dbReference type="PhylomeDB" id="O17363"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O17363">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46000:SF11">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46000">
        <property type="entry name" value="SEVEN TM RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD63234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C05E4.2a"/>
        </source>
    </evidence>
    <sequence length="351" mass="40529" checksum="157DD48FF28E5D94" modified="2001-10-01" version="2">MNISNQTFPYENYIVVSKRISHLGFCSTSFFCTILIIIIVKFSNKNVGSYKYLMIIFSVLGTLFSIVEGILCPNEHSYTASWLLFITERPFGLSPDSLTLFLVLYAVLYAATICMLSVQFVYRYCAIFHQFGLKYFEGWRMLSIAVYCSGCGILWGGSMYLFSQVDDYAKAYLRGEMSIKYGINIDNLVAFTLVAYDKDGHFRWWNSIANFILCIIMFAQYAIMMFCAVVMYRKMEENMKMMSESLRRVHRQFFRTLVIQIIAPSIFLFSPLTFILYHPFLNYAISFPSGMFLCAISLFPAIDAIVILTIVREYRNAVKKIFRYACCRRKQNEVKTSITYASTTLTTSTAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-19" modified="2026-01-28" version="199" xmlns="https://uniprot.org/uniprot">
    <accession>O61460-2</accession>
    <name>VAB1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Ephrin receptor 1</fullName>
            <ecNumber evidence="1">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Tyrosine-protein kinase Eph receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Variable abnormal protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">vab-1</name>
        <name evidence="3" type="ORF">M03A1.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Cell" volume="92" first="633" last="643">
            <title>The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans.</title>
            <authorList>
                <person name="George S.E."/>
                <person name="Simokat K."/>
                <person name="Hardin J."/>
                <person name="Chisholm A.D."/>
            </authorList>
            <dbReference type="PubMed" id="9506518"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(00)81131-9"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>MUTAGENESIS OF GLU-62; THR-63; GLU-195; GLY-917 AND CYS-966</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Genes Dev." volume="17" first="187" last="200">
            <title>An Eph receptor sperm-sensing control mechanism for oocyte meiotic maturation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Miller M.A."/>
                <person name="Ruest P.J."/>
                <person name="Kosinski M."/>
                <person name="Hanks S.K."/>
                <person name="Greenstein D."/>
            </authorList>
            <dbReference type="PubMed" id="12533508"/>
            <dbReference type="DOI" id="10.1101/gad.1028303"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-62; THR-63 AND GLY-917</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="2100" last="2109">
            <title>Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.</title>
            <authorList>
                <person name="Kaji H."/>
                <person name="Kamiie J."/>
                <person name="Kawakami H."/>
                <person name="Kido K."/>
                <person name="Yamauchi Y."/>
                <person name="Shinkawa T."/>
                <person name="Taoka M."/>
                <person name="Takahashi N."/>
                <person name="Isobe T."/>
            </authorList>
            <dbReference type="PubMed" id="17761667"/>
            <dbReference type="DOI" id="10.1074/mcp.M600392-MCP200"/>
        </citation>
        <scope>GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-238</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2009" name="Dev. Cell" volume="17" first="459" last="469">
            <title>A role for C. elegans Eph RTK signaling in PTEN regulation.</title>
            <authorList>
                <person name="Brisbin S."/>
                <person name="Liu J."/>
                <person name="Boudreau J."/>
                <person name="Peng J."/>
                <person name="Evangelista M."/>
                <person name="Chin-Sang I."/>
            </authorList>
            <dbReference type="PubMed" id="19853560"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2009.08.009"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>INTERACTION WITH DAF-18</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>PHOSPHORYLATION</scope>
        <scope>MUTAGENESIS OF GLY-917</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="Dev. Dyn." volume="244" first="417" last="430">
            <title>The C. elegans NR4A nuclear receptor gene nhr-6 promotes cell cycle progression in the spermatheca lineage.</title>
            <authorList>
                <person name="Praslicka B."/>
                <person name="Gissendanner C.R."/>
            </authorList>
            <dbReference type="PubMed" id="25529479"/>
            <dbReference type="DOI" id="10.1002/dvdy.24244"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF THR-63 AND GLY-917</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2016" name="Development" volume="143" first="1182" last="1191">
            <title>EFN-4 functions in LAD-2-mediated axon guidance in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dong B."/>
                <person name="Moseley-Alldredge M."/>
                <person name="Schwieterman A.A."/>
                <person name="Donelson C.J."/>
                <person name="McMurry J.L."/>
                <person name="Hudson M.L."/>
                <person name="Chen L."/>
            </authorList>
            <dbReference type="PubMed" id="26903502"/>
            <dbReference type="DOI" id="10.1242/dev.128934"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O61460-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_050207"/>
        </isoform>
        <isoform>
            <id>O61460-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_494807.1">
        <property type="nucleotide sequence ID" value="NM_062406.7"/>
    </dbReference>
    <dbReference type="WormBase" id="M03A1.1a">
        <property type="protein sequence ID" value="CE25060"/>
        <property type="gene ID" value="WBGene00006868"/>
        <property type="gene designation" value="vab-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="19853560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="M03A1.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="M03A1.1b"/>
        </source>
    </evidence>
    <sequence length="1117" mass="124661" checksum="6251E5DDB60E7F55" modified="1998-08-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="168" xmlns="https://uniprot.org/uniprot">
    <accession>P34183-2</accession>
    <name>SYH_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Histidine--tRNA ligase</fullName>
            <ecNumber>6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Histidyl-tRNA synthetase</fullName>
            <shortName>HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hars-1</name>
        <name evidence="3" type="synonym">hrs-1</name>
        <name evidence="1" type="synonym">syh-1</name>
        <name evidence="3" type="ORF">T11G6.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Nucleic Acids Res." volume="21" first="4344" last="4347">
            <title>Cloning and characterization of the C. elegans histidyl-tRNA synthetase gene.</title>
            <authorList>
                <person name="Amaar Y.G."/>
                <person name="Baillie D.L."/>
            </authorList>
            <dbReference type="PubMed" id="8414990"/>
            <dbReference type="DOI" id="10.1093/nar/21.18.4344"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM A)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Nucleic Acids Res." volume="21" first="6050" last="6051">
            <authorList>
                <person name="Amaar Y.G."/>
                <person name="Baillie D.L."/>
            </authorList>
            <dbReference type="PubMed" id="8290371"/>
        </citation>
        <scope>ERRATUM OF PUBMED:8414990</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="1996-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Amaar Y.G."/>
                <person name="Baillie D.L."/>
            </authorList>
        </citation>
        <scope>SEQUENCE REVISION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="6543" last="6548">
            <title>Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome.</title>
            <authorList>
                <person name="Pierce S.B."/>
                <person name="Chisholm K.M."/>
                <person name="Lynch E.D."/>
                <person name="Lee M.K."/>
                <person name="Walsh T."/>
                <person name="Opitz J.M."/>
                <person name="Li W."/>
                <person name="Klevit R.E."/>
                <person name="King M.C."/>
            </authorList>
            <dbReference type="PubMed" id="21464306"/>
            <dbReference type="DOI" id="10.1073/pnas.1103471108"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="Am. J. Physiol." volume="303" first="C1269" last="1277">
            <title>GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.</title>
            <authorList>
                <person name="Lee E.C."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23076791"/>
            <dbReference type="DOI" id="10.1152/ajpcell.00294.2012"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34183-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34183-2</id>
            <name evidence="2">a</name>
            <sequence type="described" ref="VSP_011853"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="6.1.1.21"/>
    <dbReference type="RefSeq" id="NP_001023373.2">
        <property type="nucleotide sequence ID" value="NM_001028202.5"/>
    </dbReference>
    <dbReference type="WormBase" id="T11G6.1a">
        <property type="protein sequence ID" value="CE47289"/>
        <property type="gene ID" value="WBGene00002001"/>
        <property type="gene designation" value="hars-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="8414990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="T11G6.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="T11G6.1b"/>
        </source>
    </evidence>
    <sequence length="524" mass="58709" checksum="00FF466209995893" modified="2004-11-09" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="194" xmlns="https://uniprot.org/uniprot">
    <accession>P34708-2</accession>
    <name>TRA1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Sex-determining transformer protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Hermaphrodization of XO animals protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tra-1</name>
        <name evidence="2" type="synonym">her-2</name>
        <name evidence="2" type="ORF">Y47D3A.6</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Cell" volume="70" first="237" last="249">
            <title>Molecular analysis of the C. elegans sex-determining gene tra-1: a gene encoding two zinc finger proteins.</title>
            <authorList>
                <person name="Zarkower D."/>
                <person name="Hodgkin J."/>
            </authorList>
            <dbReference type="PubMed" id="1339311"/>
            <dbReference type="DOI" id="10.1016/0092-8674(92)90099-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Nucleic Acids Res." volume="21" first="3691" last="3698">
            <title>Zinc fingers in sex determination: only one of the two C. elegans Tra-1 proteins binds DNA in vitro.</title>
            <authorList>
                <person name="Zarkower D."/>
                <person name="Hodgkin J."/>
            </authorList>
            <dbReference type="PubMed" id="8367286"/>
            <dbReference type="DOI" id="10.1093/nar/21.16.3691"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2000" name="Genes Dev." volume="14" first="3153" last="3165">
            <title>Direct protein-protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans.</title>
            <authorList>
                <person name="Lum D.H."/>
                <person name="Kuwabara P.E."/>
                <person name="Zarkower D."/>
                <person name="Spence A.M."/>
            </authorList>
            <dbReference type="PubMed" id="11124807"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH TRA-2</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2001" name="Dev. Cell" volume="1" first="539" last="551">
            <title>RNA-Regulated TRA-1 nuclear export controls sexual fate.</title>
            <authorList>
                <person name="Segal S.P."/>
                <person name="Graves L.E."/>
                <person name="Verheyden J."/>
                <person name="Goodwin E.B."/>
            </authorList>
            <dbReference type="PubMed" id="11703944"/>
            <dbReference type="DOI" id="10.1016/S1534-5807(01)00068-5"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2001" name="EMBO J." volume="20" first="1363" last="1372">
            <title>The TRA-1 transcription factor binds TRA-2 to regulate sexual fates in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Wang S."/>
                <person name="Kimble J."/>
            </authorList>
            <dbReference type="PubMed" id="11250902"/>
            <dbReference type="DOI" id="10.1093/emboj/20.6.1363"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH TRA-2</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Genes Dev." volume="21" first="3181" last="3194">
            <title>The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9.</title>
            <authorList>
                <person name="Schwartz H.T."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="18056428"/>
            <dbReference type="DOI" id="10.1101/gad.1607007"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2008" name="Development" volume="135" first="2373" last="2382">
            <title>dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans.</title>
            <authorList>
                <person name="Mason D.A."/>
                <person name="Rabinowitz J.S."/>
                <person name="Portman D.S."/>
            </authorList>
            <dbReference type="PubMed" id="18550714"/>
            <dbReference type="DOI" id="10.1242/dev.017046"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="5567" last="5581">
            <title>A role for WDR5 in TRA-1/Gli mediated transcriptional control of the sperm/oocyte switch in C. elegans.</title>
            <authorList>
                <person name="Li T."/>
                <person name="Kelly W.G."/>
            </authorList>
            <dbReference type="PubMed" id="24682813"/>
            <dbReference type="DOI" id="10.1093/nar/gku221"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="199" last="209">
            <title>Sexually Dimorphic Differentiation of a C. elegans Hub Neuron Is Cell Autonomously Controlled by a Conserved Transcription Factor.</title>
            <authorList>
                <person name="Serrano-Saiz E."/>
                <person name="Oren-Suissa M."/>
                <person name="Bayer E.A."/>
                <person name="Hobert O."/>
            </authorList>
            <dbReference type="PubMed" id="28065609"/>
            <dbReference type="DOI" id="10.1016/j.cub.2016.11.045"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34708-1</id>
            <name evidence="2">a</name>
            <name evidence="1">Tra-1L</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34708-2</id>
            <name evidence="3">b</name>
            <name evidence="1">Tra-1S</name>
            <sequence type="described" ref="VSP_006822 VSP_006821"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022881.2">
        <property type="nucleotide sequence ID" value="NM_001027710.6"/>
    </dbReference>
    <dbReference type="WormBase" id="Y47D3A.6b">
        <property type="protein sequence ID" value="CE52664"/>
        <property type="gene ID" value="WBGene00006604"/>
        <property type="gene designation" value="tra-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="8367286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="Y47D3A.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="Y47D3A.6b"/>
        </source>
    </evidence>
    <sequence length="288" mass="30905" checksum="E3790E446DCE0B42" modified="1994-02-01" version="1">MMAPSTEDPDTVVEAQRRGSFSKKKNANGWNKVELVDQCAKQMGSEDKQPGGGDVKTENDPSKNGLGSATSNFIQSSVPPSHQTLSNPLQLSPPAEASVAQQSGASQVFPTFQAALGASSDELLQPNATSSSTSSSASTSSIVPVVKFTNQTAPNGSTVATSVGQNVRLTINGKRVGRPPGTFKRPQNNAANSSNSGNDSDMMGDHDLTCRWKSCNSSFQTLKALVDHVQESHVQSTEQEHHAWRCEWEGCDRNETFKALYMLIVHVRRHTGEKPNKCEVGFGGDNEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-10-01" modified="2026-01-28" version="159" xmlns="https://uniprot.org/uniprot">
    <accession>P37165-2</accession>
    <name>RS27A_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName>Ubiquitin-like protein 1</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Small ribosomal subunit protein eS31</fullName>
            </recommendedName>
            <alternativeName>
                <fullName>40S ribosomal protein S27a</fullName>
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        </component>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps-27A</name>
        <name evidence="2" type="synonym">ubl-1</name>
        <name evidence="2" type="ORF">H06I04.4</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="J. Biol. Chem." volume="268" first="19545" last="19551">
            <title>Novel ubiquitin-like ribosomal protein fusion genes from the nematodes Caenorhabditis elegans and Caenorhabditis briggsae.</title>
            <authorList>
                <person name="Jones D."/>
                <person name="Candido E.P.M."/>
            </authorList>
            <dbReference type="PubMed" id="7690036"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P37165-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_038215 VSP_038216"/>
        </isoform>
        <isoform>
            <id>P37165-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022637.1">
        <property type="nucleotide sequence ID" value="NM_001027466.5"/>
    </dbReference>
    <dbReference type="WormBase" id="H06I04.4b">
        <property type="protein sequence ID" value="CE31022"/>
        <property type="gene ID" value="WBGene00006725"/>
        <property type="gene designation" value="rps-27A"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="H06I04.4a"/>
        </source>
    </evidence>
    <sequence length="47" mass="5260" checksum="92E90EA587A4F576" modified="2010-10-05" version="2">MVFVKTLHRTLFLEVAANEDVLSIKQKIEAAEGIPAEEQRLCYAARG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q09502-2</accession>
    <name>NPR18_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform c of Neuropeptide receptor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">npr-18</name>
        <name evidence="2" type="ORF">C43C3.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="EMBO J." volume="31" first="667" last="678">
            <title>Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mills H."/>
                <person name="Wragg R."/>
                <person name="Hapiak V."/>
                <person name="Castelletto M."/>
                <person name="Zahratka J."/>
                <person name="Harris G."/>
                <person name="Summers P."/>
                <person name="Korchnak A."/>
                <person name="Law W."/>
                <person name="Bamber B."/>
                <person name="Komuniecki R."/>
            </authorList>
            <dbReference type="PubMed" id="22124329"/>
            <dbReference type="DOI" id="10.1038/emboj.2011.422"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="J. Neurosci." volume="34" first="9389" last="9403">
            <title>Dissecting the signaling mechanisms underlying recognition and preference of food odors.</title>
            <authorList>
                <person name="Harris G."/>
                <person name="Shen Y."/>
                <person name="Ha H."/>
                <person name="Donato A."/>
                <person name="Wallis S."/>
                <person name="Zhang X."/>
                <person name="Zhang Y."/>
            </authorList>
            <dbReference type="PubMed" id="25009271"/>
            <dbReference type="DOI" id="10.1523/JNEUROSCI.0012-14.2014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09502-4</id>
            <name evidence="5">g</name>
            <sequence type="described" ref="VSP_061792"/>
        </isoform>
        <isoform>
            <id>Q09502-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09502-3</id>
            <name evidence="4">e</name>
            <sequence type="described" ref="VSP_061790"/>
        </isoform>
        <isoform>
            <id>Q09502-2</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_061791"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001368133.1">
        <property type="nucleotide sequence ID" value="NM_001381071.2"/>
    </dbReference>
    <dbReference type="WormBase" id="C43C3.2c">
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        <property type="gene ID" value="WBGene00008065"/>
        <property type="gene designation" value="npr-18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
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    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C43C3.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C43C3.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C43C3.2e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C43C3.2g"/>
        </source>
    </evidence>
    <sequence length="447" mass="51207" checksum="B6EF7E6A65BB8F23" modified="2023-02-22" version="2">MQQSDAFKGTFYENFTLVYALPLSNHDNSSLMLIAGFYALLFMFGTCGNAAILAVVHHVKGQDPRSRHNTTLTYICILSIVDFLSMLPIPMTIIDQILGFWMFDTFACKLFRLLEHIGKIFSTFILVAFSIDRYCAVCHPLQVRVRNQRTVFVFLGIMFFVTCVMLSPILLYAHSKELVMHEKVDLDQEVITRMHLYKCVDDLGRELFVVFTLYSFVLAYLMPLLFMIYFYYEMLIRLFKQANVIKQTLVGRRSGGEEKKLTIPVGHIAIYTLAICSFHFICWTPYWISILYSLYEELYQDTKSTASPPTYAFIYFMYGVHALPYINSASNFILYGLLNRQLHNAPERKYTRNGVGGRQMSHALTTNTRPEYSELIAIPSSSCRPDSRVSAMIHNNNNNTESLPLAQNISNMTNKDSATIVPMPMSANVDGNEIYNWITPDTESVIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q09502-3</accession>
    <name>NPR18_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform e of Neuropeptide receptor 18</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="primary">npr-18</name>
        <name evidence="2" type="ORF">C43C3.2</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="EMBO J." volume="31" first="667" last="678">
            <title>Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mills H."/>
                <person name="Wragg R."/>
                <person name="Hapiak V."/>
                <person name="Castelletto M."/>
                <person name="Zahratka J."/>
                <person name="Harris G."/>
                <person name="Summers P."/>
                <person name="Korchnak A."/>
                <person name="Law W."/>
                <person name="Bamber B."/>
                <person name="Komuniecki R."/>
            </authorList>
            <dbReference type="PubMed" id="22124329"/>
            <dbReference type="DOI" id="10.1038/emboj.2011.422"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="J. Neurosci." volume="34" first="9389" last="9403">
            <title>Dissecting the signaling mechanisms underlying recognition and preference of food odors.</title>
            <authorList>
                <person name="Harris G."/>
                <person name="Shen Y."/>
                <person name="Ha H."/>
                <person name="Donato A."/>
                <person name="Wallis S."/>
                <person name="Zhang X."/>
                <person name="Zhang Y."/>
            </authorList>
            <dbReference type="PubMed" id="25009271"/>
            <dbReference type="DOI" id="10.1523/JNEUROSCI.0012-14.2014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09502-2</id>
            <name evidence="3">c</name>
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        <isoform>
            <id>Q09502-4</id>
            <name evidence="5">g</name>
            <sequence type="described" ref="VSP_061792"/>
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        <isoform>
            <id>Q09502-1</id>
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        </isoform>
        <isoform>
            <id>Q09502-3</id>
            <name evidence="4">e</name>
            <sequence type="described" ref="VSP_061790"/>
        </isoform>
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    <dbReference type="RefSeq" id="NP_001257088.1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C43C3.2g"/>
        </source>
    </evidence>
    <sequence length="476" mass="54759" checksum="97BA87C434B189E3" modified="2023-02-22" version="2">MEKTPKIPDMQLFLEQSFKKLHIEQSTPARENLPNREIYQIFQFTLVYALPLSNHDNSSLMLIAGFYALLFMFGTCGNAAILAVVHHVKGQDPRSRHNTTLTYICILSIVDFLSMLPIPMTIIDQILGFWMFDTFACKLFRLLEHIGKIFSTFILVAFSIDRYCAVCHPLQVRVRNQRTVFVFLGIMFFVTCVMLSPILLYAHSKELVMHEKVDLDQEVITRMHLYKCVDDLGRELFVVFTLYSFVLAYLMPLLFMIYFYYEMLIRLFKQANVIKQTLVGRRSGGEEKKLTIPVGHIAIYTLAICSFHFICWTPYWISILYSLYEELYQDTKSTASPPTYAFIYFMYGVHALPYINSASNFILYGLLNRQLHNAPERKYTRNGVGGRQMSHALTTNTRPEYSELIAIPSSSCRPDSRVSAMIHNNNNNTESLPLAQNISNMTNKDSATIVPMPMSANVDGNEIYNWITPDTESVIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q09502-4</accession>
    <name>NPR18_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform g of Neuropeptide receptor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">npr-18</name>
        <name evidence="2" type="ORF">C43C3.2</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="EMBO J." volume="31" first="667" last="678">
            <title>Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Mills H."/>
                <person name="Wragg R."/>
                <person name="Hapiak V."/>
                <person name="Castelletto M."/>
                <person name="Zahratka J."/>
                <person name="Harris G."/>
                <person name="Summers P."/>
                <person name="Korchnak A."/>
                <person name="Law W."/>
                <person name="Bamber B."/>
                <person name="Komuniecki R."/>
            </authorList>
            <dbReference type="PubMed" id="22124329"/>
            <dbReference type="DOI" id="10.1038/emboj.2011.422"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="J. Neurosci." volume="34" first="9389" last="9403">
            <title>Dissecting the signaling mechanisms underlying recognition and preference of food odors.</title>
            <authorList>
                <person name="Harris G."/>
                <person name="Shen Y."/>
                <person name="Ha H."/>
                <person name="Donato A."/>
                <person name="Wallis S."/>
                <person name="Zhang X."/>
                <person name="Zhang Y."/>
            </authorList>
            <dbReference type="PubMed" id="25009271"/>
            <dbReference type="DOI" id="10.1523/JNEUROSCI.0012-14.2014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q09502-1</id>
            <name evidence="2">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q09502-4</id>
            <name evidence="5">g</name>
            <sequence type="described" ref="VSP_061792"/>
        </isoform>
        <isoform>
            <id>Q09502-3</id>
            <name evidence="4">e</name>
            <sequence type="described" ref="VSP_061790"/>
        </isoform>
        <isoform>
            <id>Q09502-2</id>
            <name evidence="3">c</name>
            <sequence type="described" ref="VSP_061791"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001257083.1">
        <property type="nucleotide sequence ID" value="NM_001270154.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C43C3.2g">
        <property type="protein sequence ID" value="CE47570"/>
        <property type="gene ID" value="WBGene00008065"/>
        <property type="gene designation" value="npr-18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="C43C3.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C43C3.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C43C3.2e"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C43C3.2g"/>
        </source>
    </evidence>
    <sequence length="463" mass="53069" checksum="E4E4766FBA1FC23E" modified="2023-02-22" version="2">MEINLRIDTYAVGRKTMQQSDAFKGTFYENFTLVYALPLSNHDNSSLMLIAGFYALLFMFGTCGNAAILAVVHHVKGQDPRSRHNTTLTYICILSIVDFLSMLPIPMTIIDQILGFWMFDTFACKLFRLLEHIGKIFSTFILVAFSIDRYCAVCHPLQVRVRNQRTVFVFLGIMFFVTCVMLSPILLYAHSKELVMHEKVDLDQEVITRMHLYKCVDDLGRELFVVFTLYSFVLAYLMPLLFMIYFYYEMLIRLFKQANVIKQTLVGRRSGGEEKKLTIPVGHIAIYTLAICSFHFICWTPYWISILYSLYEELYQDTKSTASPPTYAFIYFMYGVHALPYINSASNFILYGLLNRQLHNAPERKYTRNGVGGRQMSHALTTNTRPEYSELIAIPSSSCRPDSRVSAMIHNNNNNTESLPLAQNISNMTNKDSATIVPMPMSANVDGNEIYNWITPDTESVIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="206" xmlns="https://uniprot.org/uniprot">
    <accession>Q10656-2</accession>
    <name>EGL15_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Myoblast growth factor receptor egl-15</fullName>
            <ecNumber>2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Egg-laying defective protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">egl-15</name>
        <name type="ORF">F58A3.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Cell" volume="83" first="611" last="620">
            <title>An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites.</title>
            <authorList>
                <person name="Devore D.L."/>
                <person name="Horvitz H.R."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="7585964"/>
            <dbReference type="DOI" id="10.1016/0092-8674(95)90101-9"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-680 AND PRO-714</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Genes Dev." volume="12" first="1425" last="1437">
            <title>clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kokel M."/>
                <person name="Borland C.Z."/>
                <person name="DeLong L."/>
                <person name="Horvitz H.R."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="9585503"/>
        </citation>
        <scope>DEPHOSPHORYLATION BY CLR-1</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Cell. Biol." volume="21" first="8104" last="8116">
            <title>The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.</title>
            <authorList>
                <person name="Schutzman J.L."/>
                <person name="Borland C.Z."/>
                <person name="Newman J.C."/>
                <person name="Robinson M.K."/>
                <person name="Kokel M."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="11689700"/>
            <dbReference type="DOI" id="10.1128/MCB.21.23.8104-8116.2001"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Development" volume="130" first="3757" last="3766">
            <title>Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity.</title>
            <authorList>
                <person name="Goodman S.J."/>
                <person name="Branda C.S."/>
                <person name="Robinson M.K."/>
                <person name="Burdine R.D."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="12835392"/>
            <dbReference type="DOI" id="10.1242/dev.00604"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 932-1040 (ISOFORMS A; C; D AND E)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="EMBO J." volume="22" first="5058" last="5067">
            <title>Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Szewczyk N.J."/>
                <person name="Jacobson L.A."/>
            </authorList>
            <dbReference type="PubMed" id="14517244"/>
            <dbReference type="DOI" id="10.1093/emboj/cdg472"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="EMBO J." volume="24" first="2566" last="2578">
            <title>Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gottschalk A."/>
                <person name="Almedom R.B."/>
                <person name="Schedletzky T."/>
                <person name="Anderson S.D."/>
                <person name="Yates J.R. III"/>
                <person name="Schafer W.R."/>
            </authorList>
            <dbReference type="PubMed" id="15990870"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600741"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2006" name="Development" volume="133" first="1263" last="1275">
            <title>FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dixon S.J."/>
                <person name="Alexander M."/>
                <person name="Fernandes R."/>
                <person name="Ricker N."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="16495308"/>
            <dbReference type="DOI" id="10.1242/dev.02300"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-714</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Affects the maintenance of axon position without affecting axon growth. Interaction with egl-17 is required for the guidance of sex myoblast migration during gonad development.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q10656-2</id>
            <name>b</name>
            <name>EGL-15(5A)</name>
            <sequence type="described" ref="VSP_019861"/>
        </isoform>
        <isoform>
            <id>Q10656-3</id>
            <name>c</name>
            <sequence type="described" ref="VSP_002991 VSP_002992 VSP_002994"/>
        </isoform>
        <isoform>
            <id>Q10656-4</id>
            <name>d</name>
            <sequence type="described" ref="VSP_002991 VSP_019862 VSP_002992"/>
        </isoform>
        <isoform>
            <id>Q10656-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q10656-5</id>
            <name>e</name>
            <sequence type="described" ref="VSP_002992 VSP_002991 VSP_019863"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.10.1"/>
    <dbReference type="RefSeq" id="NP_001367004.1">
        <property type="nucleotide sequence ID" value="NM_001381098.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F58A3.2b">
        <property type="protein sequence ID" value="CE35726"/>
        <property type="gene ID" value="WBGene00001184"/>
        <property type="gene designation" value="egl-15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="12835392"/>
        </source>
    </evidence>
    <sequence length="988" mass="113327" checksum="A7365D218C082E49" modified="1997-11-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="206" xmlns="https://uniprot.org/uniprot">
    <accession>Q10656-3</accession>
    <name>EGL15_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Myoblast growth factor receptor egl-15</fullName>
            <ecNumber>2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Egg-laying defective protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">egl-15</name>
        <name type="ORF">F58A3.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Cell" volume="83" first="611" last="620">
            <title>An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites.</title>
            <authorList>
                <person name="Devore D.L."/>
                <person name="Horvitz H.R."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="7585964"/>
            <dbReference type="DOI" id="10.1016/0092-8674(95)90101-9"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-680 AND PRO-714</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Genes Dev." volume="12" first="1425" last="1437">
            <title>clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kokel M."/>
                <person name="Borland C.Z."/>
                <person name="DeLong L."/>
                <person name="Horvitz H.R."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="9585503"/>
        </citation>
        <scope>DEPHOSPHORYLATION BY CLR-1</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Cell. Biol." volume="21" first="8104" last="8116">
            <title>The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.</title>
            <authorList>
                <person name="Schutzman J.L."/>
                <person name="Borland C.Z."/>
                <person name="Newman J.C."/>
                <person name="Robinson M.K."/>
                <person name="Kokel M."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="11689700"/>
            <dbReference type="DOI" id="10.1128/MCB.21.23.8104-8116.2001"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Development" volume="130" first="3757" last="3766">
            <title>Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity.</title>
            <authorList>
                <person name="Goodman S.J."/>
                <person name="Branda C.S."/>
                <person name="Robinson M.K."/>
                <person name="Burdine R.D."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="12835392"/>
            <dbReference type="DOI" id="10.1242/dev.00604"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 932-1040 (ISOFORMS A; C; D AND E)</scope>
        <scope>FUNCTION</scope>
    </reference>
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        <citation type="journal article" date="2003" name="EMBO J." volume="22" first="5058" last="5067">
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                <person name="Gottschalk A."/>
                <person name="Almedom R.B."/>
                <person name="Schedletzky T."/>
                <person name="Anderson S.D."/>
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        <citation type="journal article" date="2006" name="Development" volume="133" first="1263" last="1275">
            <title>FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dixon S.J."/>
                <person name="Alexander M."/>
                <person name="Fernandes R."/>
                <person name="Ricker N."/>
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        <citation type="journal article" date="1995" name="Cell" volume="83" first="611" last="620">
            <title>An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites.</title>
            <authorList>
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                <person name="Horvitz H.R."/>
                <person name="Stern M.J."/>
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        <scope>DISRUPTION PHENOTYPE</scope>
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    <reference key="2">
        <citation type="journal article" date="1998" name="Genes Dev." volume="12" first="1425" last="1437">
            <title>clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans.</title>
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                <person name="Kokel M."/>
                <person name="Borland C.Z."/>
                <person name="DeLong L."/>
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            <dbReference type="PubMed" id="9585503"/>
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    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Cell. Biol." volume="21" first="8104" last="8116">
            <title>The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.</title>
            <authorList>
                <person name="Schutzman J.L."/>
                <person name="Borland C.Z."/>
                <person name="Newman J.C."/>
                <person name="Robinson M.K."/>
                <person name="Kokel M."/>
                <person name="Stern M.J."/>
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            <dbReference type="DOI" id="10.1128/MCB.21.23.8104-8116.2001"/>
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    <reference key="5">
        <citation type="journal article" date="2003" name="Development" volume="130" first="3757" last="3766">
            <title>Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity.</title>
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                <person name="Goodman S.J."/>
                <person name="Branda C.S."/>
                <person name="Robinson M.K."/>
                <person name="Burdine R.D."/>
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            <dbReference type="DOI" id="10.1242/dev.00604"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 932-1040 (ISOFORMS A; C; D AND E)</scope>
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    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="EMBO J." volume="22" first="5058" last="5067">
            <title>Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Szewczyk N.J."/>
                <person name="Jacobson L.A."/>
            </authorList>
            <dbReference type="PubMed" id="14517244"/>
            <dbReference type="DOI" id="10.1093/emboj/cdg472"/>
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        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="EMBO J." volume="24" first="2566" last="2578">
            <title>Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gottschalk A."/>
                <person name="Almedom R.B."/>
                <person name="Schedletzky T."/>
                <person name="Anderson S.D."/>
                <person name="Yates J.R. III"/>
                <person name="Schafer W.R."/>
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            <dbReference type="PubMed" id="15990870"/>
            <dbReference type="DOI" id="10.1038/sj.emboj.7600741"/>
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        <scope>FUNCTION</scope>
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        <citation type="journal article" date="2006" name="Development" volume="133" first="1263" last="1275">
            <title>FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dixon S.J."/>
                <person name="Alexander M."/>
                <person name="Fernandes R."/>
                <person name="Ricker N."/>
                <person name="Roy P.J."/>
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        <scope>MUTAGENESIS OF PRO-714</scope>
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        <citation type="journal article" date="1995" name="Cell" volume="83" first="611" last="620">
            <title>An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites.</title>
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                <person name="Horvitz H.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
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        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF GLU-680 AND PRO-714</scope>
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            <strain>Bristol N2</strain>
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    <reference key="2">
        <citation type="journal article" date="1998" name="Genes Dev." volume="12" first="1425" last="1437">
            <title>clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Kokel M."/>
                <person name="Borland C.Z."/>
                <person name="DeLong L."/>
                <person name="Horvitz H.R."/>
                <person name="Stern M.J."/>
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            <dbReference type="PubMed" id="9585503"/>
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    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Cell. Biol." volume="21" first="8104" last="8116">
            <title>The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.</title>
            <authorList>
                <person name="Schutzman J.L."/>
                <person name="Borland C.Z."/>
                <person name="Newman J.C."/>
                <person name="Robinson M.K."/>
                <person name="Kokel M."/>
                <person name="Stern M.J."/>
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            <dbReference type="PubMed" id="11689700"/>
            <dbReference type="DOI" id="10.1128/MCB.21.23.8104-8116.2001"/>
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        <scope>FUNCTION</scope>
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    <reference key="5">
        <citation type="journal article" date="2003" name="Development" volume="130" first="3757" last="3766">
            <title>Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity.</title>
            <authorList>
                <person name="Goodman S.J."/>
                <person name="Branda C.S."/>
                <person name="Robinson M.K."/>
                <person name="Burdine R.D."/>
                <person name="Stern M.J."/>
            </authorList>
            <dbReference type="PubMed" id="12835392"/>
            <dbReference type="DOI" id="10.1242/dev.00604"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 932-1040 (ISOFORMS A; C; D AND E)</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="EMBO J." volume="22" first="5058" last="5067">
            <title>Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Szewczyk N.J."/>
                <person name="Jacobson L.A."/>
            </authorList>
            <dbReference type="PubMed" id="14517244"/>
            <dbReference type="DOI" id="10.1093/emboj/cdg472"/>
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        <scope>FUNCTION</scope>
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    <reference key="7">
        <citation type="journal article" date="2005" name="EMBO J." volume="24" first="2566" last="2578">
            <title>Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gottschalk A."/>
                <person name="Almedom R.B."/>
                <person name="Schedletzky T."/>
                <person name="Anderson S.D."/>
                <person name="Yates J.R. III"/>
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            <dbReference type="DOI" id="10.1038/sj.emboj.7600741"/>
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        <scope>FUNCTION</scope>
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        <citation type="journal article" date="2006" name="Development" volume="133" first="1263" last="1275">
            <title>FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Dixon S.J."/>
                <person name="Alexander M."/>
                <person name="Fernandes R."/>
                <person name="Ricker N."/>
                <person name="Roy P.J."/>
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            <dbReference type="DOI" id="10.1242/dev.02300"/>
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                <person name="Lim L."/>
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    <reference evidence="3 5" key="2">
        <citation type="journal article" date="1998" name="Biochem. Biophys. Res. Commun." volume="245" first="177" last="184">
            <title>Expression pattern of the C. elegans p21-activated protein kinase, CePAK.</title>
            <authorList>
                <person name="Iino Y."/>
                <person name="Yamamoto M."/>
            </authorList>
            <dbReference type="PubMed" id="9535804"/>
            <dbReference type="DOI" id="10.1006/bbrc.1998.8380"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
            <tissue>Embryo</tissue>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Development" volume="133" first="4549" last="4559">
            <title>The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance.</title>
            <authorList>
                <person name="Lucanic M."/>
                <person name="Kiley M."/>
                <person name="Ashcroft N."/>
                <person name="L'Etoile N."/>
                <person name="Cheng H.J."/>
            </authorList>
            <dbReference type="PubMed" id="17050621"/>
            <dbReference type="DOI" id="10.1242/dev.02648"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2008" name="Curr. Biol." volume="18" first="808" last="813">
            <title>CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.</title>
            <authorList>
                <person name="Quinn C.C."/>
                <person name="Pfeil D.S."/>
                <person name="Wadsworth W.G."/>
            </authorList>
            <dbReference type="PubMed" id="18499456"/>
            <dbReference type="DOI" id="10.1016/j.cub.2008.04.050"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000269" last="E1000269">
            <title>A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.</title>
            <authorList>
                <person name="Lucanic M."/>
                <person name="Cheng H.J."/>
            </authorList>
            <dbReference type="PubMed" id="19023419"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000269"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF SER-68</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2009" name="Development" volume="136" first="3109" last="3119">
            <title>Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles.</title>
            <authorList>
                <person name="Gally C."/>
                <person name="Wissler F."/>
                <person name="Zahreddine H."/>
                <person name="Quintin S."/>
                <person name="Landmann F."/>
                <person name="Labouesse M."/>
            </authorList>
            <dbReference type="PubMed" id="19675126"/>
            <dbReference type="DOI" id="10.1242/dev.039412"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2009" name="Genetics" volume="183" first="1357" last="1372">
            <title>Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.</title>
            <authorList>
                <person name="Locke C.J."/>
                <person name="Kautu B.B."/>
                <person name="Berry K.P."/>
                <person name="Lee S.K."/>
                <person name="Caldwell K.A."/>
                <person name="Caldwell G.A."/>
            </authorList>
            <dbReference type="PubMed" id="19797046"/>
            <dbReference type="DOI" id="10.1534/genetics.109.106880"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 234-ARG-PRO-235 AND LYS-324</scope>
    </reference>
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            <id>Q17850-1</id>
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        <isoform>
            <id>Q17850-2</id>
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            <sequence type="described" ref="VSP_051596 VSP_042128"/>
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    <evidence type="ECO:0000269" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAC47308.1"/>
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    <reference evidence="3 4" key="1">
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                <person name="Chen W."/>
                <person name="Chen S."/>
                <person name="Yap S.F."/>
                <person name="Lim L."/>
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            <dbReference type="PubMed" id="8824291"/>
            <dbReference type="DOI" id="10.1074/jbc.271.42.26362"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>INTERACTION WITH CDC-42 AND CED-10</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
            <tissue evidence="1">Embryo</tissue>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="1998" name="Biochem. Biophys. Res. Commun." volume="245" first="177" last="184">
            <title>Expression pattern of the C. elegans p21-activated protein kinase, CePAK.</title>
            <authorList>
                <person name="Iino Y."/>
                <person name="Yamamoto M."/>
            </authorList>
            <dbReference type="PubMed" id="9535804"/>
            <dbReference type="DOI" id="10.1006/bbrc.1998.8380"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
            <tissue>Embryo</tissue>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Development" volume="133" first="4549" last="4559">
            <title>The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance.</title>
            <authorList>
                <person name="Lucanic M."/>
                <person name="Kiley M."/>
                <person name="Ashcroft N."/>
                <person name="L'Etoile N."/>
                <person name="Cheng H.J."/>
            </authorList>
            <dbReference type="PubMed" id="17050621"/>
            <dbReference type="DOI" id="10.1242/dev.02648"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2008" name="Curr. Biol." volume="18" first="808" last="813">
            <title>CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.</title>
            <authorList>
                <person name="Quinn C.C."/>
                <person name="Pfeil D.S."/>
                <person name="Wadsworth W.G."/>
            </authorList>
            <dbReference type="PubMed" id="18499456"/>
            <dbReference type="DOI" id="10.1016/j.cub.2008.04.050"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000269" last="E1000269">
            <title>A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.</title>
            <authorList>
                <person name="Lucanic M."/>
                <person name="Cheng H.J."/>
            </authorList>
            <dbReference type="PubMed" id="19023419"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000269"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF SER-68</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2009" name="Development" volume="136" first="3109" last="3119">
            <title>Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles.</title>
            <authorList>
                <person name="Gally C."/>
                <person name="Wissler F."/>
                <person name="Zahreddine H."/>
                <person name="Quintin S."/>
                <person name="Landmann F."/>
                <person name="Labouesse M."/>
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            <dbReference type="PubMed" id="19675126"/>
            <dbReference type="DOI" id="10.1242/dev.039412"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2009" name="Genetics" volume="183" first="1357" last="1372">
            <title>Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.</title>
            <authorList>
                <person name="Locke C.J."/>
                <person name="Kautu B.B."/>
                <person name="Berry K.P."/>
                <person name="Lee S.K."/>
                <person name="Caldwell K.A."/>
                <person name="Caldwell G.A."/>
            </authorList>
            <dbReference type="PubMed" id="19797046"/>
            <dbReference type="DOI" id="10.1534/genetics.109.106880"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 234-ARG-PRO-235 AND LYS-324</scope>
    </reference>
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            <id>Q17850-3</id>
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        <isoform>
            <id>Q17850-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_051596 VSP_042128"/>
        </isoform>
        <isoform>
            <id>Q17850-1</id>
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        <source>
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    </evidence>
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    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAC47308.1"/>
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        <source>
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    </evidence>
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<entry dataset="TrEMBL" created="1996-11-01" modified="2025-10-08" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q18951</accession>
    <name>Q18951_CAEEL</name>
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        <submittedName>
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    <reference evidence="3 4" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
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            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2011" name="Nat. Cell Biol." volume="13" first="1189" last="1201">
            <title>Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis.</title>
            <authorList>
                <person name="Zhang H."/>
                <person name="Abraham N."/>
                <person name="Khan L.A."/>
                <person name="Hall D.H."/>
                <person name="Fleming J.T."/>
                <person name="Gobel V."/>
            </authorList>
            <dbReference type="PubMed" id="21926990"/>
            <dbReference type="DOI" id="10.1038/ncb2328"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q20375-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q20375-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_045379"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.3.1.50"/>
    <dbReference type="RefSeq" id="NP_505064.1">
        <property type="nucleotide sequence ID" value="NM_072663.7"/>
    </dbReference>
    <dbReference type="WormBase" id="F43H9.2b">
        <property type="protein sequence ID" value="CE27380"/>
        <property type="gene ID" value="WBGene00018398"/>
        <property type="gene designation" value="sptl-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="586" mass="66014" checksum="9878E62F8E434CE7" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-01-24" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q2PJ75</accession>
    <name>Q2PJ75_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ERAP1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C14C10.2</name>
        <name evidence="1" type="ORF">CELE_C14C10.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAJ55251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041083.1">
        <property type="nucleotide sequence ID" value="NM_001047618.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2PJ75"/>
    <dbReference type="SMR" id="Q2PJ75"/>
    <dbReference type="GeneID" id="179723"/>
    <dbReference type="UCSC" id="C14C10.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00007585"/>
    <dbReference type="CTD" id="179723"/>
    <dbReference type="WormBase" id="C14C10.2b">
        <property type="protein sequence ID" value="CE39471"/>
        <property type="gene ID" value="WBGene00007585"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_807085_0_0_1"/>
    <dbReference type="OrthoDB" id="5844176at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007585">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2PJ75">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ55251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C14C10.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="Q2PJ75"/>
        </source>
    </evidence>
    <sequence length="318" mass="37199" checksum="53D2D7A6FBA11073" modified="2006-01-24" version="1">MVARIAKQSFESAAERKNTITSIQNIIRCSLTEFEKGAEDYRIFRETRDTPDWGVVRMSSIAMSHQRSEQAELFLKQQMEEYGGSARRQARNVDVSDDQICAAIQRVLNKDKTGNSAFQFFEFLKKYKFCSNRDVFARVLIEFTVKKFGWKAGLERLNELVHKDQRTKSMTMSVFFILEDAWNAKEFEQAEILLSKTKFIKPSTLRSLQLFIRFNEMPRLEIADYCKPMPLIRLLEIHQFIQIPTSTFFSIFDELIKLAGKSGKTENLEELMWKVKANREVSDNQKSILYGKIRHFYKCLNVKAPEKLYILINCTDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-01-24" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q2PJ78</accession>
    <name>Q2PJ78_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C05D12.3</name>
        <name evidence="3" type="ORF">CELE_C05D12.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAJ55249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367135.1">
        <property type="nucleotide sequence ID" value="NM_001381605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2PJ78"/>
    <dbReference type="SMR" id="Q2PJ78"/>
    <dbReference type="PeptideAtlas" id="Q2PJ78"/>
    <dbReference type="GeneID" id="174742"/>
    <dbReference type="KEGG" id="cel:CELE_C05D12.3"/>
    <dbReference type="UCSC" id="C05D12.3c.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00014666"/>
    <dbReference type="CTD" id="174742"/>
    <dbReference type="WormBase" id="C05D12.3c">
        <property type="protein sequence ID" value="CE39469"/>
        <property type="gene ID" value="WBGene00014666"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299616_0_0_1"/>
    <dbReference type="OrthoDB" id="5851513at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014666">
        <property type="expression patterns" value="Expressed in material anatomical entity and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2PJ78">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053295">
        <property type="entry name" value="Innate_immunity_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324">
        <property type="entry name" value="PROTEIN IRG-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004213637" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAJ55249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C05D12.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q2PJ78"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112655" checksum="F21551A4707EA0C3" modified="2006-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q58AU1</accession>
    <name>Q58AU1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">tkr-3</name>
        <name evidence="14" type="ORF">AC7.1</name>
        <name evidence="12" type="ORF">CELE_AC7.1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD61150.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343604.1">
        <property type="nucleotide sequence ID" value="NM_001356921.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q58AU1"/>
    <dbReference type="SMR" id="Q58AU1"/>
    <dbReference type="GeneID" id="177285"/>
    <dbReference type="KEGG" id="cel:CELE_AC7.1"/>
    <dbReference type="UCSC" id="AC7.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00006428"/>
    <dbReference type="CTD" id="177285"/>
    <dbReference type="WormBase" id="AC7.1b">
        <property type="protein sequence ID" value="CE52241"/>
        <property type="gene ID" value="WBGene00006428"/>
        <property type="gene designation" value="tkr-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_6_1_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006428">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q58AU1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF57">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="63"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD61150.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="AC7.1b"/>
        </source>
    </evidence>
    <sequence length="385" mass="44332" checksum="B28E4707E3C43B27" modified="2017-12-20" version="2">MNFSATDSILASTITTVIGGAGVLAEAGEAELSGDDDFYELTPVELIIWCMLYAIIAFMAVVGNLLVLYITLFRLRVRSITTYFILNLGFADLFTGIFAIPFKFQAALFQEWFLPRSLCRIVPYVETVALTVSVFTLVTSAVHEFRTMFFSKCSQMSPRSAKRCVLLIWIMAVLVSLPHGLFHNTYEFPDDNNTSIVQCLPVYPDAGWWKTYNVYLVIIQYFVPMIILDTAYTMIAVKIWSLSQSRVELDETKMATQKLMRTLIIVVACFSLCWFPLETYLLLNELKPEINGWKYINLVFFFSHWLAMSNSCLNPIIYGLYNTKYNEEYRRLFRQIGCIWQRQKSLDDSMKPERRWNSSNDCQDQQEIDQIVDIPPVISTNNLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>Q58AU4</accession>
    <name>Q58AU4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Diacylglycerol kinase</fullName>
            <shortName evidence="13">DAG kinase</shortName>
            <ecNumber evidence="13">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">dgk-1</name>
        <name evidence="20" type="ORF">C09E10.2</name>
        <name evidence="18" type="ORF">CELE_C09E10.2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="13"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD63968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367484.1">
        <property type="nucleotide sequence ID" value="NM_001380904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q58AU4"/>
    <dbReference type="PeptideAtlas" id="Q58AU4"/>
    <dbReference type="GeneID" id="180452"/>
    <dbReference type="UCSC" id="C09E10.2e">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000958"/>
    <dbReference type="CTD" id="180452"/>
    <dbReference type="WormBase" id="C09E10.2e">
        <property type="protein sequence ID" value="CE38270"/>
        <property type="gene ID" value="WBGene00000958"/>
        <property type="gene designation" value="dgk-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000958">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q58AU4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007212">
        <property type="term" value="P:G protein-coupled dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046834">
        <property type="term" value="P:lipid phosphorylation"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040013">
        <property type="term" value="P:negative regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046662">
        <property type="term" value="P:regulation of egg-laying behavior"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040012">
        <property type="term" value="P:regulation of locomotion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032094">
        <property type="term" value="P:response to food"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007210">
        <property type="term" value="P:serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd20803">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20804">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20854">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17111">
        <property type="entry name" value="RA1_DAGK-theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000004">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000324">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000053">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000011">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056392">
        <property type="entry name" value="DGKtheta_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24099">
        <property type="entry name" value="RBD_DGKtheta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="149"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="17">
        <location>
            <begin position="249"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="17">
        <location>
            <begin position="322"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="16">
        <location>
            <begin position="511"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="857"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCD63968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="C09E10.2e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PeptideAtlas" id="Q58AU4"/>
        </source>
    </evidence>
    <sequence length="919" mass="103171" checksum="436CF04A681946D0" modified="2005-04-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q58AU5</accession>
    <name>Q58AU5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Diacylglycerol kinase</fullName>
            <shortName evidence="13">DAG kinase</shortName>
            <ecNumber evidence="13">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">dgk-1</name>
        <name evidence="19" type="ORF">C09E10.2</name>
        <name evidence="17" type="ORF">CELE_C09E10.2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCD63967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001367483.1">
        <property type="nucleotide sequence ID" value="NM_001380902.1"/>
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    <dbReference type="AlphaFoldDB" id="Q58AU5"/>
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    <dbReference type="UCSC" id="C09E10.2e">
        <property type="organism name" value="c. elegans"/>
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    <dbReference type="AGR" id="WB:WBGene00000958"/>
    <dbReference type="CTD" id="180452"/>
    <dbReference type="WormBase" id="C09E10.2d">
        <property type="protein sequence ID" value="CE38269"/>
        <property type="gene ID" value="WBGene00000958"/>
        <property type="gene designation" value="dgk-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000958">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q58AU5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
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        <property type="term" value="C:cell body"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="GOC"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
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        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0000353"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007212">
        <property type="term" value="P:G protein-coupled dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="P:lipid phosphorylation"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007210">
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd20803">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20804">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20854">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000004">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000002">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000053">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000011">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056392">
        <property type="entry name" value="DGKtheta_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00781">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF24099">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="149"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="16">
        <location>
            <begin position="388"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="734"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCD63967.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
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    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="Q58AU5"/>
        </source>
    </evidence>
    <sequence length="796" mass="88750" checksum="43F4CA2E8FC6EDEB" modified="2005-04-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q58AU6</accession>
    <name>Q58AU6_CAEEL</name>
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        <recommendedName>
            <fullName evidence="13">Diacylglycerol kinase</fullName>
            <shortName evidence="13">DAG kinase</shortName>
            <ecNumber evidence="13">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="17 19" type="primary">dgk-1</name>
        <name evidence="19" type="ORF">C09E10.2</name>
        <name evidence="17" type="ORF">CELE_C09E10.2</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="13"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="WBGene00000958"/>
        <property type="gene designation" value="dgk-1"/>
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    <sequence length="794" mass="88479" checksum="B1102C5714E69F3A" modified="2005-04-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2025-10-08" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I111</accession>
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        <recommendedName>
            <fullName evidence="9">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
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    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
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            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
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    <dbReference type="EC" id="1.2.4.1" evidence="9"/>
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        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7 9 11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="77"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD59156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="T05H10.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="Q8I111"/>
        </source>
    </evidence>
    <sequence length="414" mass="45806" checksum="BA46AA022B9E1D1F" modified="2003-03-01" version="1">MTKFLSLVHLERIWSTAMSLFARQLQSLTASGIRTQQVRLASTEVSFHTKPCKLHKLDNGPNTSVTLNREDALKYYRDMQVIRRMESAAGNLYKEKKIRGFCHLYSGQEACAVGMKAAMTEGDAVITAYRCHGWTWLLGATVTEVLAELTGRVAGNVHGKGGSMHMYTKNFYGGNGIVGAQQPLGAGVALAMKYREQKNVCVTLYGDGAANQGQLFEATNMAKLWDLPVLFVCENNGFGMGTTAERSSASTEYYTRGDYVPGIWVDGMDILAVREATKWAKEYCDSGKGPLMMEMATYRYHGHSMSDPGTSYRTREEIQEVRKTRDPITGFKDRIITSSLATEEELKAIDKEVRKEVDEALKIATSDGVLPPEALYADIYHNTPAQEIRGATIDETIVQPFKTSADVLKSIGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2025-10-08" version="170" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I120</accession>
    <name>Q8I120_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">ptp-3</name>
        <name evidence="14" type="ORF">C09D8.1</name>
        <name evidence="12" type="ORF">CELE_C09D8.1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAD59171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001021944.1">
        <property type="nucleotide sequence ID" value="NM_001026773.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I120"/>
    <dbReference type="SMR" id="Q8I120"/>
    <dbReference type="GeneID" id="174685"/>
    <dbReference type="AGR" id="WB:WBGene00004215"/>
    <dbReference type="CTD" id="174685"/>
    <dbReference type="WormBase" id="C09D8.1c">
        <property type="protein sequence ID" value="CE32793"/>
        <property type="gene ID" value="WBGene00004215"/>
        <property type="gene designation" value="ptp-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004215">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8I120">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005001">
        <property type="term" value="F:transmembrane receptor protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010172">
        <property type="term" value="P:embryonic body morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008544">
        <property type="term" value="P:epidermis development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007369">
        <property type="term" value="P:gastrulation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035418">
        <property type="term" value="P:protein localization to synapse"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14553">
        <property type="entry name" value="R-PTPc-LAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002339">
        <property type="entry name" value="Protein-tyrosine-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000147">
        <property type="entry name" value="Protein-tyrosine-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF531">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE LAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="94"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="197"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="663"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="838"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="949"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="1123"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD59171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="C09D8.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="Q8I120"/>
        </source>
    </evidence>
    <sequence length="1216" mass="137834" checksum="C3381A2FD6E96E1E" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I132</accession>
    <name>Q8I132_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chloride channel CLIC-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">ooc-3</name>
        <name evidence="12" type="ORF">B0334.11</name>
        <name evidence="10" type="ORF">CELE_B0334.11</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel MCLC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAD59139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_871910.1">
        <property type="nucleotide sequence ID" value="NM_182110.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I132"/>
    <dbReference type="TCDB" id="1.A.36.2.1">
        <property type="family name" value="the intracellular chloride channel (icc) family"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q8I132"/>
    <dbReference type="GeneID" id="174759"/>
    <dbReference type="AGR" id="WB:WBGene00003868"/>
    <dbReference type="CTD" id="174759"/>
    <dbReference type="WormBase" id="B0334.11b">
        <property type="protein sequence ID" value="CE32788"/>
        <property type="gene ID" value="WBGene00003868"/>
        <property type="gene designation" value="ooc-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5837276at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003868">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8I132">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="WormBase"/>
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        <property type="project" value="WormBase"/>
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    <keyword evidence="9" id="KW-0732">Signal</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004309791" description="Chloride channel CLIC-like protein 1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAD59139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="B0334.11b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="Q8I132"/>
        </source>
    </evidence>
    <sequence length="446" mass="50743" checksum="8B5C107DE5A24992" modified="2003-03-01" version="1">MKIIWVTLLLLVPQLFATQDIDEEFTHENVWKDPNDPTSGESPPASKRLLSVRNQVQKPDQSLRLILRQLLHETKIDYHLEGSIKKDVQIKISRHSMSVLSKYLKNDEADLAEEREAVRSALSNIFSVKPPAPDRTWQDTFVTLQPFIFTLNIFILPAAAFVVLRSIVRPRNFWILVLSTALLVSMYSGYSKKYQEAESRRFAQFQEHAHDSCATEGLLSRMVEILASPFQYRQKSKCLKYIESQTISIFHEISIIEVFSETISGGFFAFFSGSAKHFNLFFRNLYDGAPLIAQIVMTIFLVLMLGAIRTPFFSYEPIWLNFCSSSIGKIAGWLDGEPPQQPAPQLLITAKEMKRLEQARNKKPEMISYPTSEREDVVSGSENGNEKKSDNEREESMKMEEDSAPVESSLEDDLSLLGESSEDEDEEKVNESPAKIDSTTLSESSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-12" modified="2026-01-28" version="154" xmlns="https://uniprot.org/uniprot">
    <accession>Q93380-2</accession>
    <name>UNC93_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Putative potassium channel regulatory protein unc-93</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Uncoordinated protein 93</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">unc-93</name>
        <name type="ORF">C46F11.1</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1992" name="J. Cell Biol." volume="117" first="143" last="155">
            <title>The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction.</title>
            <authorList>
                <person name="Levin J.Z."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="1313436"/>
            <dbReference type="DOI" id="10.1083/jcb.117.1.143"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ALA-49; GLY-388 AND GLY-562</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2003" name="J. Neurosci." volume="23" first="9133" last="9145">
            <title>sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.</title>
            <authorList>
                <person name="de la Cruz I.P."/>
                <person name="Levin J.Z."/>
                <person name="Cummins C."/>
                <person name="Anderson P."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="14534247"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="PLoS Genet." volume="12" first="E1006010" last="E1006010">
            <title>The MADD-3 LAMMER kinase interacts with a p38 MAP kinase pathway to regulate the display of the EVA-1 guidance receptor in Caenorhabditis elegans.</title>
            <authorList>
                <person name="D'Souza S.A."/>
                <person name="Rajendran L."/>
                <person name="Bagg R."/>
                <person name="Barbier L."/>
                <person name="van Pel D.M."/>
                <person name="Moshiri H."/>
                <person name="Roy P.J."/>
            </authorList>
            <dbReference type="PubMed" id="27123983"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1006010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative initiation"/>
        <isoform>
            <id>Q93380-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_018911"/>
        </isoform>
        <isoform>
            <id>Q93380-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001366876.1">
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    </dbReference>
    <dbReference type="WormBase" id="C46F11.1b">
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        <property type="gene ID" value="WBGene00006822"/>
        <property type="gene designation" value="unc-93"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
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    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="CAA45760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="CAB03760.3"/>
        </source>
    </evidence>
    <sequence length="700" mass="79689" checksum="8289FE53ED43E8E4" modified="2005-04-12" version="4"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N5D6-2</accession>
    <name>UNC62_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Homeobox protein unc-62</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Uncoordinated protein 62</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">unc-62</name>
        <name type="ORF">T28F12.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2002" name="Development" volume="129" first="5255" last="5268">
            <title>Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis.</title>
            <authorList>
                <person name="Van Auken K."/>
                <person name="Weaver D."/>
                <person name="Robertson B."/>
                <person name="Sundaram M."/>
                <person name="Saldi T."/>
                <person name="Edgar L."/>
                <person name="Elling U."/>
                <person name="Lee M."/>
                <person name="Boese Q."/>
                <person name="Wood W.B."/>
            </authorList>
            <dbReference type="PubMed" id="12399316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; E AND F)</scope>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2005" name="Development" volume="132" first="1413" last="1428">
            <title>The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development.</title>
            <authorList>
                <person name="Yang L."/>
                <person name="Sym M."/>
                <person name="Kenyon C."/>
            </authorList>
            <dbReference type="PubMed" id="15750187"/>
            <dbReference type="DOI" id="10.1242/dev.01569"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2019" name="Dev. Cell" volume="49" first="235" last="250.e7">
            <title>CEH-60/PBX and UNC-62/MEIS Coordinate a Metabolic Switch that Supports Reproduction in C. elegans.</title>
            <authorList>
                <person name="Dowen R.H."/>
            </authorList>
            <dbReference type="PubMed" id="30956009"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2019.03.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CEH-60</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2019" name="PLoS Biol." volume="17" first="e3000499" last="e3000499">
            <title>CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Van de Walle P."/>
                <person name="Geens E."/>
                <person name="Baggerman G."/>
                <person name="Jose Naranjo-Galindo F."/>
                <person name="Askjaer P."/>
                <person name="Schoofs L."/>
                <person name="Temmerman L."/>
            </authorList>
            <dbReference type="PubMed" id="31675356"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.3000499"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CEH-60</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9N5D6-7</id>
            <name evidence="2">g</name>
            <sequence type="described" ref="VSP_052828"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-5</id>
            <name evidence="1">e</name>
            <name evidence="1">1b-7a</name>
            <sequence type="described" ref="VSP_052829 VSP_052832"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-6</id>
            <name evidence="1">f</name>
            <name evidence="1">1a-7a</name>
            <sequence type="described" ref="VSP_052832"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-1</id>
            <name evidence="1">a</name>
            <name evidence="1">1a-7b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-4</id>
            <name evidence="2">d</name>
            <sequence type="described" ref="VSP_052827"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-2</id>
            <name evidence="1">b</name>
            <name evidence="1">1b-7b</name>
            <sequence type="described" ref="VSP_052829"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-3</id>
            <name evidence="2">c</name>
            <sequence type="described" ref="VSP_052831 VSP_052830"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024170.1">
        <property type="nucleotide sequence ID" value="NM_001028999.5"/>
    </dbReference>
    <dbReference type="WormBase" id="T28F12.2b">
        <property type="protein sequence ID" value="CE21220"/>
        <property type="gene ID" value="WBGene00006796"/>
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    </dbReference>
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        <property type="component" value="Chromosome V"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="12399316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAL65143.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="56785" checksum="49390A493D81DA85" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N5D6-3</accession>
    <name>UNC62_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Homeobox protein unc-62</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Uncoordinated protein 62</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">unc-62</name>
        <name type="ORF">T28F12.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2002" name="Development" volume="129" first="5255" last="5268">
            <title>Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis.</title>
            <authorList>
                <person name="Van Auken K."/>
                <person name="Weaver D."/>
                <person name="Robertson B."/>
                <person name="Sundaram M."/>
                <person name="Saldi T."/>
                <person name="Edgar L."/>
                <person name="Elling U."/>
                <person name="Lee M."/>
                <person name="Boese Q."/>
                <person name="Wood W.B."/>
            </authorList>
            <dbReference type="PubMed" id="12399316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; E AND F)</scope>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2005" name="Development" volume="132" first="1413" last="1428">
            <title>The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development.</title>
            <authorList>
                <person name="Yang L."/>
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                <person name="Sundaram M."/>
                <person name="Saldi T."/>
                <person name="Edgar L."/>
                <person name="Elling U."/>
                <person name="Lee M."/>
                <person name="Boese Q."/>
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                <person name="Sym M."/>
                <person name="Kenyon C."/>
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        <citation type="journal article" date="2019" name="PLoS Biol." volume="17" first="e3000499" last="e3000499">
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                <person name="Geens E."/>
                <person name="Baggerman G."/>
                <person name="Jose Naranjo-Galindo F."/>
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                <person name="Schoofs L."/>
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                <person name="Sundaram M."/>
                <person name="Saldi T."/>
                <person name="Edgar L."/>
                <person name="Elling U."/>
                <person name="Lee M."/>
                <person name="Boese Q."/>
                <person name="Wood W.B."/>
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                <person name="Kenyon C."/>
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                <person name="Geens E."/>
                <person name="Baggerman G."/>
                <person name="Jose Naranjo-Galindo F."/>
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                <person name="Schoofs L."/>
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                <person name="Van Auken K."/>
                <person name="Weaver D."/>
                <person name="Robertson B."/>
                <person name="Sundaram M."/>
                <person name="Saldi T."/>
                <person name="Edgar L."/>
                <person name="Elling U."/>
                <person name="Lee M."/>
                <person name="Boese Q."/>
                <person name="Wood W.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; E AND F)</scope>
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        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2005" name="Development" volume="132" first="1413" last="1428">
            <title>The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development.</title>
            <authorList>
                <person name="Yang L."/>
                <person name="Sym M."/>
                <person name="Kenyon C."/>
            </authorList>
            <dbReference type="PubMed" id="15750187"/>
            <dbReference type="DOI" id="10.1242/dev.01569"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2019" name="Dev. Cell" volume="49" first="235" last="250.e7">
            <title>CEH-60/PBX and UNC-62/MEIS Coordinate a Metabolic Switch that Supports Reproduction in C. elegans.</title>
            <authorList>
                <person name="Dowen R.H."/>
            </authorList>
            <dbReference type="PubMed" id="30956009"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2019.03.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CEH-60</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2019" name="PLoS Biol." volume="17" first="e3000499" last="e3000499">
            <title>CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Van de Walle P."/>
                <person name="Geens E."/>
                <person name="Baggerman G."/>
                <person name="Jose Naranjo-Galindo F."/>
                <person name="Askjaer P."/>
                <person name="Schoofs L."/>
                <person name="Temmerman L."/>
            </authorList>
            <dbReference type="PubMed" id="31675356"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.3000499"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CEH-60</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9N5D6-3</id>
            <name evidence="2">c</name>
            <sequence type="described" ref="VSP_052831 VSP_052830"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-7</id>
            <name evidence="2">g</name>
            <sequence type="described" ref="VSP_052828"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-5</id>
            <name evidence="1">e</name>
            <name evidence="1">1b-7a</name>
            <sequence type="described" ref="VSP_052829 VSP_052832"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-6</id>
            <name evidence="1">f</name>
            <name evidence="1">1a-7a</name>
            <sequence type="described" ref="VSP_052832"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-1</id>
            <name evidence="1">a</name>
            <name evidence="1">1a-7b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-4</id>
            <name evidence="2">d</name>
            <sequence type="described" ref="VSP_052827"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-2</id>
            <name evidence="1">b</name>
            <name evidence="1">1b-7b</name>
            <sequence type="described" ref="VSP_052829"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367924.1">
        <property type="nucleotide sequence ID" value="NM_001380634.1"/>
    </dbReference>
    <dbReference type="WormBase" id="T28F12.2f">
        <property type="protein sequence ID" value="CE33585"/>
        <property type="gene ID" value="WBGene00006796"/>
        <property type="gene designation" value="unc-62"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="12399316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAL65143.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="60331" checksum="067C84F274B9CBEE" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N5D6-7</accession>
    <name>UNC62_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform g of Homeobox protein unc-62</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Uncoordinated protein 62</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">unc-62</name>
        <name type="ORF">T28F12.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2002" name="Development" volume="129" first="5255" last="5268">
            <title>Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis.</title>
            <authorList>
                <person name="Van Auken K."/>
                <person name="Weaver D."/>
                <person name="Robertson B."/>
                <person name="Sundaram M."/>
                <person name="Saldi T."/>
                <person name="Edgar L."/>
                <person name="Elling U."/>
                <person name="Lee M."/>
                <person name="Boese Q."/>
                <person name="Wood W.B."/>
            </authorList>
            <dbReference type="PubMed" id="12399316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; E AND F)</scope>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2005" name="Development" volume="132" first="1413" last="1428">
            <title>The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development.</title>
            <authorList>
                <person name="Yang L."/>
                <person name="Sym M."/>
                <person name="Kenyon C."/>
            </authorList>
            <dbReference type="PubMed" id="15750187"/>
            <dbReference type="DOI" id="10.1242/dev.01569"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2019" name="Dev. Cell" volume="49" first="235" last="250.e7">
            <title>CEH-60/PBX and UNC-62/MEIS Coordinate a Metabolic Switch that Supports Reproduction in C. elegans.</title>
            <authorList>
                <person name="Dowen R.H."/>
            </authorList>
            <dbReference type="PubMed" id="30956009"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2019.03.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CEH-60</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2019" name="PLoS Biol." volume="17" first="e3000499" last="e3000499">
            <title>CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Van de Walle P."/>
                <person name="Geens E."/>
                <person name="Baggerman G."/>
                <person name="Jose Naranjo-Galindo F."/>
                <person name="Askjaer P."/>
                <person name="Schoofs L."/>
                <person name="Temmerman L."/>
            </authorList>
            <dbReference type="PubMed" id="31675356"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.3000499"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CEH-60</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9N5D6-3</id>
            <name evidence="2">c</name>
            <sequence type="described" ref="VSP_052830 VSP_052831"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-6</id>
            <name evidence="1">f</name>
            <name evidence="1">1a-7a</name>
            <sequence type="described" ref="VSP_052832"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-5</id>
            <name evidence="1">e</name>
            <name evidence="1">1b-7a</name>
            <sequence type="described" ref="VSP_052832 VSP_052829"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-7</id>
            <name evidence="2">g</name>
            <sequence type="described" ref="VSP_052828"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-1</id>
            <name evidence="1">a</name>
            <name evidence="1">1a-7b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-4</id>
            <name evidence="2">d</name>
            <sequence type="described" ref="VSP_052827"/>
        </isoform>
        <isoform>
            <id>Q9N5D6-2</id>
            <name evidence="1">b</name>
            <name evidence="1">1b-7b</name>
            <sequence type="described" ref="VSP_052829"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001024175.1">
        <property type="nucleotide sequence ID" value="NM_001029004.5"/>
    </dbReference>
    <dbReference type="WormBase" id="T28F12.2g">
        <property type="protein sequence ID" value="CE37795"/>
        <property type="gene ID" value="WBGene00006796"/>
        <property type="gene designation" value="unc-62"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="12399316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="9851916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AAL65143.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="52864" checksum="D49161AD4AE797EF" modified="2000-10-01" version="1">MGGAPTSTPMMHHEMGEAMKRDKESIYAHPLYPLLVLLFEKCELATSTPRDTSRDGSTSSDVCSSASFKDDLNEFVRHTQENADKQYYVPNPQLDQIMLQSIQMLRFHLLELEKVHELCDNFCNRYVVCLKGKMPLDIVGDERASSSQPPMSPGSMGHLGHSSSPSMAGGATPMHYPPPYEPQSVPLPENAGVMGGHPMEGSSMAYSMAGMAAAAASSSSSSNQAGDHPLANGGTLHSTAGASQTLLPIAVSSPSTCSSGGLRQDSTPLSGETPMGHANGNSMDSISEAGDEFSVCGSNDDGRDSVLSDSANGSQNGKRKVPKVFSKEAITKFRAWLFHNLTHPYPSEEQKKQLAKETGLTILQVNNWFINARRRIVQPMIDQNNRAGRSGQMNVCKNRRRNRSEQSPGPSPDSGSDSGANYSPDPSSLAASTAMPYPAEFYMQRTMPYGGFPSFTNPAMPFMNPMMGFQVAPTVDALSQQWVDLSAPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXR6</accession>
    <name>Q9XXR6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLD phosphodiesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_Y51A2D.13</name>
        <name evidence="4 6" type="ORF">Y51A2D.13</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA16397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T27069">
        <property type="entry name" value="T27069"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_507632.1">
        <property type="nucleotide sequence ID" value="NM_075231.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XXR6"/>
    <dbReference type="SMR" id="Q9XXR6"/>
    <dbReference type="DIP" id="DIP-25272N"/>
    <dbReference type="GeneID" id="180213"/>
    <dbReference type="KEGG" id="cel:CELE_Y51A2D.13"/>
    <dbReference type="UCSC" id="Y51A2D.13a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013080"/>
    <dbReference type="CTD" id="180213"/>
    <dbReference type="WormBase" id="Y51A2D.13a">
        <property type="protein sequence ID" value="CE19209"/>
        <property type="gene ID" value="WBGene00013080"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027021_0_0_1"/>
    <dbReference type="OrthoDB" id="1923775at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013080">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XXR6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09106">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09107">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF25">
        <property type="entry name" value="PLD PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA16397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="Y51A2D.13a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XXR6"/>
        </source>
    </evidence>
    <sequence length="487" mass="55153" checksum="9431DDB2B79731CC" modified="1999-11-01" version="1">MTMAQESNELKYKFTISGFVILLIPFLTIGLITKLPEKPEIQLVRDRQCFNTCKLRIVETIPANISFGEDTVFPLSTFRAWKSLISNAQEELYVAAYKSSLQGKHVLGDSAKYYSVEGDSIYNTLMAVGKSRKVAVRMVENYPPKDKGDNADGVILENFGAVTRKSIDISEYMGRGKMHSKFLVADRKSFYLGSANLDWRSLNQKMELGVLVEDCECLGEDMHNIFHVLWDLKNKGIESNGALKVKAAYNKEYPLEMQVQGAKAQVYIATSPKELNNPRRTWDLDAIVSEIDAAKKFIDIHVMDYFPLFIYRNPRVHFSNIDDAIRRAVVRGVKIRFLAAALHYPDIGTRFLRSLESLNGFHANGTMEVKIFKVPRTNIESIVINRERRTHNKFMVTESAGIIGTSNWSGDYFMGGTTGAAIVIRQTGEKRPFVDELKDIFTRDWESAYSHPLDEYFEKCVTSNTGDFCEGTKDPRLFATPVTANSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-11-09" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>Q9Y048-2</accession>
    <name>DTN1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Dystrobrevin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dyb-1</name>
        <name type="ORF">F47G6.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="1999" name="FEBS Lett." volume="461" first="59" last="62">
            <title>In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin.</title>
            <authorList>
                <person name="Gieseler K."/>
                <person name="Abdel-Dayem M."/>
                <person name="Segalat L."/>
            </authorList>
            <dbReference type="PubMed" id="10561496"/>
            <dbReference type="DOI" id="10.1016/S0014-5793(99)01421-0"/>
        </citation>
        <scope>INTERACTION WITH STN-1 AND DYS-1</scope>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="1999" name="Neurogenetics" volume="2" first="87" last="90">
            <title>Dystrobrevin- and dystrophin-like mutants display similar phenotypes in the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gieseler K."/>
                <person name="Bessou C."/>
                <person name="Segalat L."/>
            </authorList>
            <dbReference type="PubMed" id="10369883"/>
            <dbReference type="DOI" id="10.1007/s100480050057"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="1">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2001" name="J. Mol. Biol." volume="307" first="107" last="117">
            <title>Molecular, genetic and physiological characterisation of dystrobrevin-like (dyb-1) mutants of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gieseler K."/>
                <person name="Mariol M.-C."/>
                <person name="Bessou C."/>
                <person name="Migaud M."/>
                <person name="Franks C.J."/>
                <person name="Holden-Dye L."/>
                <person name="Segalat L."/>
            </authorList>
            <dbReference type="PubMed" id="11243807"/>
            <dbReference type="DOI" id="10.1006/jmbi.2000.4480"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2002" name="Eur. J. Biochem." volume="269" first="1607" last="1612">
            <title>Dystrobrevin requires a dystrophin-binding domain to function in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Grisoni K."/>
                <person name="Gieseler K."/>
                <person name="Segalat L."/>
            </authorList>
            <dbReference type="PubMed" id="11895430"/>
            <dbReference type="DOI" id="10.1046/j.1432-1327.2002.02780.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH DYS-1</scope>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2002" name="Neuromuscul. Disord." volume="12" first="371" last="377">
            <title>Overexpression of dystrobrevin delays locomotion defects and muscle degeneration in a dystrophin-deficient Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gieseler K."/>
                <person name="Grisoni K."/>
                <person name="Mariol M.-C."/>
                <person name="Segalat L."/>
            </authorList>
            <dbReference type="PubMed" id="12062255"/>
            <dbReference type="DOI" id="10.1016/S0960-8966(01)00330-3"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="2" key="7">
        <citation type="journal article" date="2003" name="J. Mol. Biol." volume="332" first="1037" last="1046">
            <title>The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin.</title>
            <authorList>
                <person name="Grisoni K."/>
                <person name="Gieseler K."/>
                <person name="Mariol M.-C."/>
                <person name="Martin E."/>
                <person name="Carre-Pierrat M."/>
                <person name="Moulder G."/>
                <person name="Barstead R."/>
                <person name="Segalat L."/>
            </authorList>
            <dbReference type="PubMed" id="14499607"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2003.08.021"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH STN-1</scope>
    </reference>
    <reference evidence="2" key="8">
        <citation type="journal article" date="2012" name="J. Biol. Chem." volume="287" first="21717" last="21728">
            <title>Interaction of alpha-catulin with dystrobrevin contributes to integrity of dystrophin complex in muscle.</title>
            <authorList>
                <person name="Oh H.J."/>
                <person name="Abraham L.S."/>
                <person name="van Hengel J."/>
                <person name="Stove C."/>
                <person name="Proszynski T.J."/>
                <person name="Gevaert K."/>
                <person name="DiMario J.X."/>
                <person name="Sanes J.R."/>
                <person name="van Roy F."/>
                <person name="Kim H."/>
            </authorList>
            <dbReference type="PubMed" id="22577143"/>
            <dbReference type="DOI" id="10.1074/jbc.m112.369496"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CTN-1</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF 38-GLN--PHE-590</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9Y048-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_062387"/>
        </isoform>
        <isoform>
            <id>Q9Y048-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001420389.1">
        <property type="nucleotide sequence ID" value="NM_001433452.1"/>
    </dbReference>
    <dbReference type="WormBase" id="F47G6.1b">
        <property type="protein sequence ID" value="CE49501"/>
        <property type="gene ID" value="WBGene00001115"/>
        <property type="gene designation" value="dyb-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="10369883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F47G6.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F47G6.1b"/>
        </source>
    </evidence>
    <sequence length="512" mass="56542" checksum="90FB074844E4ACAB" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKM4</accession>
    <name>A0A061AKM4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_F59B8.1</name>
        <name evidence="1 3" type="ORF">F59B8.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293889.1">
        <property type="nucleotide sequence ID" value="NM_001306960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AKM4"/>
    <dbReference type="SMR" id="A0A061AKM4"/>
    <dbReference type="GeneID" id="177774"/>
    <dbReference type="AGR" id="WB:WBGene00010316"/>
    <dbReference type="CTD" id="177774"/>
    <dbReference type="WormBase" id="F59B8.1c">
        <property type="protein sequence ID" value="CE49875"/>
        <property type="gene ID" value="WBGene00010316"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10052054at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010316">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AKM4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21010">
        <property type="entry name" value="AGAP001581-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21010:SF3">
        <property type="entry name" value="DAXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR32645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F59B8.1c"/>
        </source>
    </evidence>
    <sequence length="234" mass="26972" checksum="0470F7FDE59ACC60" modified="2014-09-03" version="1">MDVMLNILMSMTKEGASDGPQFVAPAKTSRDTLITTAYRLHRTRWRILEPYRRLKNALKKLQEDYLKSKEANALMRYVKLGQSVREVAMLEKQYWKLLNIPAQEGTEDANCYVVKIIELLEDTPTQLPPTRGIGALLQSTIGKPAEANVDTVLHDSLKARKSEDLVKECEGLYAQLYRLTKKYLGLRRLIKELHDKYEATRMFPIVPRYAMLKKMIKATLRAPEFADICHEQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKP8</accession>
    <name>A0A061AKP8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calcium-dependent secretion activator</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Uncoordinated protein 31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">unc-31</name>
        <name evidence="18" type="ORF">CELE_ZK897.1</name>
        <name evidence="20" type="ORF">ZK897.1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001293901.1">
        <property type="nucleotide sequence ID" value="NM_001306972.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A061AKP8"/>
    <dbReference type="GeneID" id="178233"/>
    <dbReference type="AGR" id="WB:WBGene00006767"/>
    <dbReference type="CTD" id="178233"/>
    <dbReference type="WormBase" id="ZK897.1j">
        <property type="protein sequence ID" value="CE49911"/>
        <property type="gene ID" value="WBGene00006767"/>
        <property type="gene designation" value="unc-31"/>
    </dbReference>
    <dbReference type="OMA" id="FAFCATH"/>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006767">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AKP8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0098793">
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        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="SynGO"/>
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    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd01234">
        <property type="entry name" value="PH_CADPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000343">
        <property type="entry name" value="Calcium-dependent secretion activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000239">
        <property type="entry name" value="Calcium-dependent secretion activator"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
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    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057457">
        <property type="entry name" value="CAPS_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25341">
        <property type="entry name" value="C2_CAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="449"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="588"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="17">
        <location>
            <begin position="987"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="106"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR32666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="ZK897.1j"/>
        </source>
    </evidence>
    <sequence length="1401" mass="158851" checksum="0ECEF10E25FF01E7" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKQ5</accession>
    <name>A0A061AKQ5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calcium-dependent secretion activator</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Uncoordinated protein 31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">unc-31</name>
        <name evidence="18" type="ORF">CELE_ZK897.1</name>
        <name evidence="20" type="ORF">ZK897.1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293906.1">
        <property type="nucleotide sequence ID" value="NM_001306977.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A061AKQ5"/>
    <dbReference type="GeneID" id="178233"/>
    <dbReference type="AGR" id="WB:WBGene00006767"/>
    <dbReference type="CTD" id="178233"/>
    <dbReference type="WormBase" id="ZK897.1o">
        <property type="protein sequence ID" value="CE49924"/>
        <property type="gene ID" value="WBGene00006767"/>
        <property type="gene designation" value="unc-31"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006767">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AKQ5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="SynGO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01234">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000343">
        <property type="entry name" value="Calcium-dependent secretion activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000239">
        <property type="entry name" value="Calcium-dependent secretion activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057457">
        <property type="entry name" value="CAPS_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25341">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="430"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="569"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="17">
        <location>
            <begin position="964"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="106"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDR32671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="ZK897.1o"/>
        </source>
    </evidence>
    <sequence length="1378" mass="156177" checksum="8A811EF5F6E3051D" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKR6</accession>
    <name>A0A061AKR6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2</fullName>
            <ecNumber evidence="3">2.7.12.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Dual specificity Yak1-related kinase mbk-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Minibrain Kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">mbk-2</name>
        <name evidence="20" type="ORF">CELE_F49E11.1</name>
        <name evidence="22" type="ORF">F49E11.1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis. Through phosphorylation of P granule components including meg-1, promotes the disassembly of zygotic P granules in the anterior cytoplasm during zygote polarization, and thus plays a role in P granule distribution and segregation in early stage embryos following meiosis. Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos. Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="3"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_001293916.1">
        <property type="nucleotide sequence ID" value="NM_001306987.4"/>
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    <dbReference type="AlphaFoldDB" id="A0A061AKR6"/>
    <dbReference type="SMR" id="A0A061AKR6"/>
    <dbReference type="GeneID" id="178250"/>
    <dbReference type="AGR" id="WB:WBGene00003150"/>
    <dbReference type="CTD" id="178250"/>
    <dbReference type="WormBase" id="F49E11.1k">
        <property type="protein sequence ID" value="CE49822"/>
        <property type="gene ID" value="WBGene00003150"/>
        <property type="gene designation" value="mbk-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018023_0_0_1"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003150">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AKR6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14224">
        <property type="entry name" value="PKc_DYRK2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000127">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF112">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="444"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="70"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="284"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070595"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDR32681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="F49E11.1k"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AKR6"/>
        </source>
    </evidence>
    <sequence length="779" mass="85576" checksum="847866443602A01D" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKS3</accession>
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        <submittedName>
            <fullName evidence="1">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
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        <name evidence="1 3" type="primary">nhr-38</name>
        <name evidence="1" type="ORF">CELE_K01H12.3</name>
        <name evidence="3" type="ORF">K01H12.3</name>
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    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
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    <dbReference type="EMBL" id="BX284604">
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    <dbReference type="RefSeq" id="NP_001293921.1">
        <property type="nucleotide sequence ID" value="NM_001306992.3"/>
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        <property type="gene ID" value="WBGene00003629"/>
        <property type="gene designation" value="nhr-38"/>
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        <property type="component" value="Chromosome IV"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR32686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="K01H12.3b"/>
        </source>
    </evidence>
    <sequence length="184" mass="21072" checksum="DD17D5C4B94C4B9B" modified="2014-09-03" version="1">MRRISTGSPLIMQVIEHFYAHFGSLDNNFMSDPLGDIFLLVFVFEACVLTATKGGIQLDRLFLPNMVHIDLSEQPFLEFMECEQHVNLNPYRNILNSFSFLVQLVSRSFQSCNFDEPLLSILFYKCITEAVPINFRHCFADVNRDSLLTDLNRVDPVSFEQIQNTSAQIHQGTRAFKDAISSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKT4</accession>
    <name>A0A061AKT4_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="3 5" type="primary">eps-8</name>
        <name evidence="3" type="ORF">CELE_Y57G11C.24</name>
        <name evidence="5" type="ORF">Y57G11C.24</name>
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    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001307002.3"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A061AKT4"/>
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    <dbReference type="AGR" id="WB:WBGene00001330"/>
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    <dbReference type="WormBase" id="Y57G11C.24m">
        <property type="protein sequence ID" value="CE49955"/>
        <property type="gene ID" value="WBGene00001330"/>
        <property type="gene designation" value="eps-8"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014510_1_1_1"/>
    <dbReference type="OrthoDB" id="4680325at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001330">
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EPS8-like"/>
    </dbReference>
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        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDR32696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="179" mass="20483" checksum="572A8FE7499C6109" modified="2014-09-03" version="1">MEELLRMQQQQQQKQRKPPVEEPVYQPQPAQRAGLEIWRRNQNPQLIQEVTETVGQHSGDILRPAMQRATRVAINEKSSPEDVTRWLQEKGFSPRVIDLLDGQDGANLFSLSKLHLQQACGRDEGGYLYSQLLVQKKRSGFRTHTGDELKAILNHRRTHVELSNEAAADEPVFTINPIL</sequence>
</entry>
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    <accession>A0A061AKU0</accession>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
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        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="term" value="P:endocytosis"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
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        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
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        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
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        <property type="entry name" value="Vitamin K-dependent protein S"/>
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    </dbReference>
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        <property type="match status" value="7"/>
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        <property type="match status" value="12"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="chain" id="PRO_5001593995" evidence="16">
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        <location>
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    </feature>
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        <location>
            <begin position="812"/>
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        <location>
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    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="989"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1075"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1247"/>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1290"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1418"/>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1508"/>
            <end position="1538"/>
        </location>
    </feature>
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            <begin position="143"/>
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        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
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        <location>
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        </location>
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    <feature type="disulfide bond" evidence="15">
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
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    <feature type="disulfide bond" evidence="15">
        <location>
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        </location>
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    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1528"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDR32701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WormBase" id="Y64G10A.7e"/>
        </source>
    </evidence>
    <sequence length="1563" mass="168107" checksum="07028E7C9E0EB244" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AL29</accession>
    <name>A0A061AL29_CAEEL</name>
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        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
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        <name evidence="8" type="ORF">CELE_ZC518.1</name>
        <name evidence="10" type="ORF">ZC518.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
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</entry>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0804">Transcription</keyword>
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            <end position="134"/>
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            <end position="134"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
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            <end position="157"/>
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            <end position="16"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CTQ86372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="R13H8.1l"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
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            <dbReference type="PeptideAtlas" id="A0A0K3AR95"/>
        </source>
    </evidence>
    <sequence length="407" mass="44727" checksum="4E5CA10AF689DBEF" modified="2015-11-11" version="1">MLHTPDGSNSHQTSFPSDFRMSESPDDTVSGKKTTTRRNAWGNMSYAELITTAIMASPEKRLTLAQVYEWMVQNVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFMRIQNEGAGKSSWWVINPDAKPGRNPRRTRERSNTIETTTKAQLEKSRRGAKKRIKERALMGSLHSTLNGNSIAGSIQTISHDLYDDDSMQGAFDNVPSSFRPRTQSNLSIPGSSSRVSPAIGSDIYDDLEFPSWVGESVPAIPSDIVDRTDQMRIDATTHIGGVQIKQESKPIKTEPIAPPPSYHELNSVRGSCAQNPLLRNPIVPSTNFKPMPLPGAYGNYQNGGITPINWLSTSNSSPLPGIQSCGIVAAQHTVASSSALPIDLENLTLPDQPLMDTMDVDALIRHELSQAGGQHIHFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR97</accession>
    <name>A0A0K3AR97_CAEEL</name>
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            <fullName evidence="2">CEntrosomal Protein</fullName>
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        <name evidence="2 4" type="primary">ccep-135</name>
        <name evidence="2" type="ORF">CELE_H06I04.1</name>
        <name evidence="4" type="ORF">H06I04.1</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001377917.2"/>
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        <property type="protein sequence ID" value="CE20943"/>
        <property type="gene ID" value="WBGene00019167"/>
        <property type="gene designation" value="ccep-135"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5850475at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019167">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR97">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="H06I04.1e"/>
        </source>
    </evidence>
    <sequence length="259" mass="30085" checksum="CA965AF78CBCE7CE" modified="2015-11-11" version="1">MSREMDILLREKLEMQRNSQELEKKYKKAKFASRELAKILENDLCGTPTTSNLKNFESDDEFFEEKSLFEKSRALSRQQIPNDLLEKTRKIDFSEAKNAKNQDLIDKLIDENENLQISLNREQKMTSSLQDDLEKSRRMVIDRDEHIEELKMKLGKAETKASQCESDLTQTSSDLAMERLRCEVLTGELHEIDGIFRNTQSTIQAYADDNDRLEDQCRQAQRTILTLNSKLEAQGIDLVTTKRTLRALRETNEARSGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARB1</accession>
    <name>A0A0K3ARB1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rhgf-3</name>
        <name evidence="8" type="ORF">CELE_Y105E8A.25</name>
        <name evidence="10" type="ORF">Y105E8A.25</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300448.1">
        <property type="nucleotide sequence ID" value="NM_001313519.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARB1"/>
    <dbReference type="SMR" id="A0A0K3ARB1"/>
    <dbReference type="PeptideAtlas" id="A0A0K3ARB1"/>
    <dbReference type="GeneID" id="3564893"/>
    <dbReference type="AGR" id="WB:WBGene00013682"/>
    <dbReference type="CTD" id="3564893"/>
    <dbReference type="WormBase" id="Y105E8A.25c">
        <property type="protein sequence ID" value="CE50141"/>
        <property type="gene ID" value="WBGene00013682"/>
        <property type="gene designation" value="rhgf-3"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3520">
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    </dbReference>
    <dbReference type="OrthoDB" id="28045at2759"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013682">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARB1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF21">
        <property type="entry name" value="CYSTS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="7">
        <location>
            <begin position="280"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="774"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1080"/>
        </location>
    </feature>
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        <location>
            <begin position="959"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1017"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1055"/>
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        <location>
            <begin position="655"/>
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        <location>
            <begin position="824"/>
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        <location>
            <begin position="852"/>
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            <begin position="882"/>
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        </location>
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        <location>
            <begin position="893"/>
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            <end position="957"/>
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            <begin position="969"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CTQ86595.1"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="WormBase" id="Y111B2A.14k"/>
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            <dbReference type="PeptideAtlas" id="A0A0K3ARB9"/>
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    <sequence length="1063" mass="121379" checksum="DEEB3BC7F061C8B9" modified="2015-11-11" version="1"> </sequence>
</entry>
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                <person name="WormBase"/>
            </authorList>
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</entry>
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    <reference evidence="2 3" key="1">
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
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        <property type="component" value="Chromosome III"/>
    </dbReference>
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            <end position="172"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="66"/>
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    </feature>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
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    <dbReference type="AGR" id="WB:WBGene00021547"/>
    <dbReference type="CTD" id="189904"/>
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        <property type="gene ID" value="WBGene00021547"/>
    </dbReference>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021547">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CTQ86402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y44E3A.1d"/>
        </source>
    </evidence>
    <sequence length="39" mass="4589" checksum="9D2126EDC2E1D731" modified="2015-11-11" version="1">MAQREYEIRKLEGINAIIISTRNMILSCEKKNECKLFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C2U3</accession>
    <name>A0A2C9C2U3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F13D12.10</name>
        <name evidence="2 4" type="ORF">F13D12.10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C2U3"/>
    <dbReference type="AGR" id="WB:WBGene00008744"/>
    <dbReference type="WormBase" id="F13D12.10b">
        <property type="protein sequence ID" value="CE52402"/>
        <property type="gene ID" value="WBGene00008744"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5819967at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008744">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C2U3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F13D12.10b"/>
        </source>
    </evidence>
    <sequence length="155" mass="17873" checksum="04AF5A416A3DF97B" modified="2017-12-20" version="1">MSEVSLAIFEYIHCRVDGNPLSAVFAAIFTFHSLFTTFYIIGAFRLVECLMVPWLTLQLIFLTTFAMFVVVWWIATLLSIFNLVQYYHTPSDQGLTNAEFFVLTGIVLTLVLFLCMKLSHILYKGFVSVRTQNMTRYRITESVQRTDSVLKPSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C2U6</accession>
    <name>A0A2C9C2U6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C-CAP/cofactor C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C54G6.2</name>
        <name evidence="1" type="ORF">CELE_C54G6.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SOF58714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343723.1">
        <property type="nucleotide sequence ID" value="NM_001356797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C2U6"/>
    <dbReference type="GeneID" id="183814"/>
    <dbReference type="AGR" id="WB:WBGene00016931"/>
    <dbReference type="CTD" id="183814"/>
    <dbReference type="WormBase" id="C54G6.2c">
        <property type="protein sequence ID" value="CE52086"/>
        <property type="gene ID" value="WBGene00016931"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016931">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C2U6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SOF58714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C54G6.2c"/>
        </source>
    </evidence>
    <sequence length="78" mass="9141" checksum="9B066F1BE23156F5" modified="2017-12-20" version="1">METSRFVCQHTPLHTSDKQFEMLLNSLPEEYRVAHHRNAQDAQKMISLDPEKCRLTDVTSNFDLLFLKSKIEKIHVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C2V3</accession>
    <name>A0A2C9C2V3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Muscle M-line assembly protein unc-89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">unc-89</name>
        <name evidence="15" type="ORF">C09D1.1</name>
        <name evidence="13" type="ORF">CELE_C09D1.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Myofibril</location>
            <location evidence="8">Sarcomere</location>
            <location evidence="8">M line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SOF58701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343711.1">
        <property type="nucleotide sequence ID" value="NM_001356814.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2C9C2V3"/>
    <dbReference type="GeneID" id="171990"/>
    <dbReference type="AGR" id="WB:WBGene00006820"/>
    <dbReference type="CTD" id="171990"/>
    <dbReference type="WormBase" id="C09D1.1h">
        <property type="protein sequence ID" value="CE52068"/>
        <property type="gene ID" value="WBGene00006820"/>
        <property type="gene designation" value="unc-89"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006820">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C2V3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd20973">
        <property type="entry name" value="IgI_telokin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14109">
        <property type="entry name" value="PK_Unc-89_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14112">
        <property type="entry name" value="STKc_Unc-89_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000902">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000344">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000345">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000507">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000519">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001409">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001436">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002188">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002248">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002469">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000080">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="50"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007850">
        <property type="entry name" value="RCSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF3">
        <property type="entry name" value="STRIATED MUSCLE PREFERENTIALLY EXPRESSED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="46"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05177">
        <property type="entry name" value="RCSD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="46"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="40"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="48"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="44"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="95"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="175"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="275"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SOF58711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343721.1">
        <property type="nucleotide sequence ID" value="NM_001356801.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C2W7"/>
    <dbReference type="SMR" id="A0A2C9C2W7"/>
    <dbReference type="GeneID" id="171884"/>
    <dbReference type="AGR" id="WB:WBGene00003654"/>
    <dbReference type="CTD" id="171884"/>
    <dbReference type="WormBase" id="C45E1.1c">
        <property type="protein sequence ID" value="CE52156"/>
        <property type="gene ID" value="WBGene00003654"/>
        <property type="gene designation" value="nhr-64"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003654">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C2W7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000026">
        <property type="entry name" value="Hepatocyte nuclear factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="126"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SOF58711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="C45E1.1c"/>
        </source>
    </evidence>
    <sequence length="375" mass="42545" checksum="C98554B4494BE8CE" modified="2017-12-20" version="1">MSETEEMTLEEKEEVSTSTSQSPQSSSFENVFCAICGDRATGKHYGAMSCDGCKGFFRRTIRKRHSYVCRFGEKCQVDKAKRNSCRKCRFDVCLRKGMRRDAVQTERDRIRPANPLSNGSNGGIVPDDPLLDTLIRAEASTRGLRTTVITKTAEARKQATTNDVTDSMNQQLTLMVEWAKVLEGFQRVDNITQVALLRHFSAQHLVMCAAFRSIHLSDAVWLTNETCLHKDSPKIPDMNRVAERIIDQVTNPMRSLHMNEIEYIALKAIAFFDPLAKGITSESYSDVEEMRQRILESFERHVRYVSPYKDMPLRFANLLLLLPPMLAISRDLVEDVQLAKLFGLASIDNLMLELMLPNEGKNTTDKTSPPIMCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C2W9</accession>
    <name>A0A2C9C2W9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Muscle M-line assembly protein unc-89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">unc-89</name>
        <name evidence="19" type="ORF">C09D1.1</name>
        <name evidence="17" type="ORF">CELE_C09D1.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Myofibril</location>
            <location evidence="8">Sarcomere</location>
            <location evidence="8">M line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SOF58706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343716.1">
        <property type="nucleotide sequence ID" value="NM_001356808.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2C9C2W9"/>
    <dbReference type="GeneID" id="171990"/>
    <dbReference type="AGR" id="WB:WBGene00006820"/>
    <dbReference type="CTD" id="171990"/>
    <dbReference type="WormBase" id="C09D1.1m">
        <property type="protein sequence ID" value="CE52124"/>
        <property type="gene ID" value="WBGene00006820"/>
        <property type="gene designation" value="unc-89"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006820">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C2W9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd20973">
        <property type="entry name" value="IgI_telokin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13325">
        <property type="entry name" value="PH_unc89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14112">
        <property type="entry name" value="STKc_Unc-89_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000902">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000064">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000344">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000345">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000507">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000519">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001409">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001436">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002188">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002248">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002469">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000080">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="50"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
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    <dbReference type="InterPro" id="IPR013106">
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</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001360428.1">
        <property type="nucleotide sequence ID" value="NM_001373716.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C2X1"/>
    <dbReference type="SMR" id="A0A2C9C2X1"/>
    <dbReference type="GeneID" id="173940"/>
    <dbReference type="AGR" id="WB:WBGene00015894"/>
    <dbReference type="CTD" id="173940"/>
    <dbReference type="WormBase" id="C17C3.12e">
        <property type="protein sequence ID" value="CE52058"/>
        <property type="gene ID" value="WBGene00015894"/>
        <property type="gene designation" value="acdh-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015894">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C2X1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000043">
        <property type="entry name" value="Acyl CoA DeHydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000026">
        <property type="entry name" value="Acyl-CoA dehydrogenase medium chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF6">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="6">
        <location>
            <begin position="38"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="5">
        <location>
            <begin position="152"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SOF58734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C17C3.12e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C2X1"/>
        </source>
    </evidence>
    <sequence length="273" mass="29878" checksum="1D29B2EB1BBB2650" modified="2017-12-20" version="1">MFKVPRKLPISAISTFSTTGSISAQQQPRVFPLQHLNENEKKLVEKVKNFAQSSVKPLVREMDRDARINKQLLKKAFDLKLMGLKIDPKYGGSGVSFFELVLAVEELSKIDPAIALIMHLQNALVAPLIEEFGNEELKEKYLKKLCKDSVGAFALSEVVSGSDAFAMQTVAKKDGDHFILNGSKWGISNAPIADFFLVLANADPEKGYRGVTCFIVDRDHEGVVLGEQDDNLGMRAGTIAQVHLNSVRVPKTSIVGEYGKGSSTPNCKNSNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C2X2</accession>
    <name>A0A2C9C2X2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Ryanodine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">unc-68</name>
        <name evidence="20" type="ORF">CELE_K11C4.5</name>
        <name evidence="22" type="ORF">K11C4.5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343814.1">
        <property type="nucleotide sequence ID" value="NM_001356685.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2C9C2X2"/>
    <dbReference type="GeneID" id="179080"/>
    <dbReference type="AGR" id="WB:WBGene00006801"/>
    <dbReference type="CTD" id="179080"/>
    <dbReference type="WormBase" id="K11C4.5k">
        <property type="protein sequence ID" value="CE52322"/>
        <property type="gene ID" value="WBGene00006801"/>
        <property type="gene designation" value="unc-68"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300855at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006801">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C2X2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23278">
        <property type="entry name" value="beta-trefoil_MIR_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12877">
        <property type="entry name" value="SPRY1_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12878">
        <property type="entry name" value="SPRY2_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000052">
        <property type="entry name" value="CBN-UNC-68 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000006">
        <property type="entry name" value="Protein CBR-LIPL-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000132">
        <property type="entry name" value="Ryanodine receptor 44F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000017">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000003">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000003">
        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000022">
        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000021">
        <property type="entry name" value="Ryanodine receptor, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035761">
        <property type="entry name" value="SPRY1_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035764">
        <property type="entry name" value="SPRY2_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035762">
        <property type="entry name" value="SPRY3_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
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        <location>
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            <begin position="4937"/>
            <end position="4959"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="4979"/>
            <end position="5004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="5064"/>
            <end position="5083"/>
        </location>
    </feature>
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        <location>
            <begin position="102"/>
            <end position="156"/>
        </location>
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            <begin position="580"/>
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        <location>
            <begin position="1004"/>
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        </location>
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        <location>
            <begin position="1475"/>
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        <location>
            <begin position="4296"/>
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        </location>
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            <begin position="1326"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="4646"/>
            <end position="4663"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SOF58812.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="K11C4.5k"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C2X2"/>
        </source>
    </evidence>
    <sequence length="5185" mass="589082" checksum="3B25D98FDF5DD9F1" modified="2017-12-20" version="1"> </sequence>
</entry>
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    <reference evidence="2 3" key="1">
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            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PAN"/>
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    </dbReference>
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        </location>
    </feature>
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            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SOF58770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T05B9.2c"/>
        </source>
    </evidence>
    <sequence length="246" mass="28170" checksum="2DDF1325B80D805A" modified="2017-12-20" version="1">MCHEPSTSAEQSTDCLETVFLPVETVPDTVSFLFDSAFRIGTRSQCIILLLMALFIPCSAKGKCFNTQIGMSIEGGNYRRIRNFVDRECAKECIEDFSCFGYEWNSEEKICYLKSRSTSGKLIAKPNTMVGFCQDDDEVRYRLQDHVIVGPIVMEADDVPDGEECKENCRKVGALYYSWRPNSDNQRSNVVPVEEEEDDEEQEVLGHCECISTMNELRLEYDAFSGFIPIPKHKHRRSILLRPFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C2Y3</accession>
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        <submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Peloderinae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="W01B11.2b"/>
        </source>
    </evidence>
    <sequence length="106" mass="11433" checksum="DE82398A858A8197" modified="2017-12-20" version="1">MFVSVSDAVDQAELEQRHKTETVQTTAAPKATVVPPVAKSVGQKSVPITEPVLVPIQSSASLVTGIDFSMKENTAKGGKFPNPTRKLRVPSKLSLMEELEKTDKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C2Y5</accession>
    <name>A0A2C9C2Y5_CAEEL</name>
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        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
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    <gene>
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        <name evidence="9" type="ORF">CELE_F08B1.1</name>
        <name evidence="11" type="ORF">F08B1.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
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    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001434913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C2Y5"/>
    <dbReference type="SMR" id="A0A2C9C2Y5"/>
    <dbReference type="GeneID" id="173904"/>
    <dbReference type="AGR" id="WB:WBGene00006923"/>
    <dbReference type="CTD" id="173904"/>
    <dbReference type="WormBase" id="F08B1.1d">
        <property type="protein sequence ID" value="CE52228"/>
        <property type="gene ID" value="WBGene00006923"/>
        <property type="gene designation" value="vhp-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006923">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C2Y5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14568">
        <property type="entry name" value="DSP_MKP_classIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
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        <property type="entry name" value="Tyr_Pase_dom"/>
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        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
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        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF533">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE VHP-1"/>
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        <property type="entry name" value="DSPc"/>
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        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
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        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
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        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
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    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="104"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="167"/>
            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="282"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="586"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="295"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SOF58744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F08B1.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C2Y5"/>
        </source>
    </evidence>
    <sequence length="586" mass="62879" checksum="55850D2DA14C6AED" modified="2017-12-20" version="1"> </sequence>
</entry>
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    <accession>A0A2C9C2Y8</accession>
    <name>A0A2C9C2Y8_CAEEL</name>
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        <submittedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7 9" type="primary">jun-1</name>
        <name evidence="7" type="ORF">CELE_T24H10.7</name>
        <name evidence="9" type="ORF">T24H10.7</name>
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    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the bZIP family. Jun subfamily.</text>
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    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58780.1"/>
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    <dbReference type="CTD" id="174452"/>
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        <property type="protein sequence ID" value="CE52056"/>
        <property type="gene ID" value="WBGene00012005"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AP-1_TF_bZIP"/>
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        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
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        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BZIP_BASIC"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
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        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006882"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SOF58780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="T24H10.7i"/>
        </source>
    </evidence>
    <sequence length="216" mass="23499" checksum="775FB8E8BE43C8DD" modified="2017-12-20" version="1">MHTIVMSLLGNTPITSGPSIAPLSSPTLLPLVTSGDLDDLSMKILASSAIPGPPIISSSNSPDSSTTAVTTSQITAFQPLLNNFVSSTTASTSRPDKLNLTPPQQSAEIYAFNGVNSDDSDGGLDSRSASRCGMALDDQEKKKLERKRARNRQAATKCRQKKMDRIKELEEQVLHEKHRGQRLDAELLELNRALEHFRRTVEHHSGNGCPNNSIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C2Z1</accession>
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        <submittedName>
            <fullName evidence="11">KASH domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="11 13" type="primary">anc-1</name>
        <name evidence="11" type="ORF">CELE_ZK973.6</name>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nesprin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SOF58726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001356818.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2C9C2Z1"/>
    <dbReference type="GeneID" id="172034"/>
    <dbReference type="AGR" id="WB:WBGene00000140"/>
    <dbReference type="CTD" id="172034"/>
    <dbReference type="WormBase" id="ZK973.6b">
        <property type="protein sequence ID" value="CE52283"/>
        <property type="gene ID" value="WBGene00000140"/>
        <property type="gene designation" value="anc-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000140">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C2Z1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ANC1_spectrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012315">
        <property type="entry name" value="KASH"/>
    </dbReference>
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        <property type="entry name" value="Spectrin_Anc-1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057134">
        <property type="entry name" value="Spectrin_Anc-1_3"/>
    </dbReference>
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        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24531">
        <property type="entry name" value="ANC1_spectrin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10541">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24611">
        <property type="entry name" value="Spectrin_Anc-1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24615">
        <property type="entry name" value="Spectrin_Anc-1_2"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="BAG"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="7489"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="7">
        <location>
            <begin position="7511"/>
            <end position="7540"/>
        </location>
    </feature>
    <feature type="domain" description="KASH" evidence="10">
        <location>
            <begin position="7481"/>
            <end position="7540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2005"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2908"/>
            <end position="2931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3367"/>
            <end position="3390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3862"/>
            <end position="3885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4765"/>
            <end position="4788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="5668"/>
            <end position="5691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="6571"/>
            <end position="6594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="7386"/>
            <end position="7413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SOF58832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="E02A10.3e"/>
        </source>
    </evidence>
    <sequence length="184" mass="21265" checksum="70F15798ED0B8FA1" modified="2017-12-20" version="1">MPKLKLHSDRGDGNSPHGIADPLLSQHLLEGYSEEELQEYRQVFNMFDADRSGAIAIDELEAAIKNLGLEQTRDELDKIIDEVDQRGNHQIDFDEFCVVMRRLTMKKSNWNEVVKECFTVFDRSENGGISKKDFRFILRELGDITDNQIIDEIFNEADVDGNGVIDYDEFTYMVKNYMTDDDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C362</accession>
    <name>A0A2C9C362_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CELE_F31F7.2</name>
        <name evidence="4 6" type="ORF">F31F7.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C362"/>
    <dbReference type="SMR" id="A0A2C9C362"/>
    <dbReference type="AGR" id="WB:WBGene00017965"/>
    <dbReference type="WormBase" id="F31F7.2b">
        <property type="protein sequence ID" value="CE52407"/>
        <property type="gene ID" value="WBGene00017965"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256829at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017965">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C362">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052229">
        <property type="entry name" value="Collagen-VI/PIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588:SF14">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="254"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SOF58843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F31F7.2b"/>
        </source>
    </evidence>
    <sequence length="459" mass="53050" checksum="167D87436AAAD439" modified="2017-12-20" version="1">MSKIIADVSWWNFLNWNSTSCHRQNAEQTVFWTVPCSSSTRFGPLCWIIIASILFFAIILTALLAYAIYSYHEENRRLRHRVTESERQLRKQNEYFTSQLHTEMQKQITYGEKHAEEMKKQQDMMQAQFDRQLDMAYQQGSKIQILPPFNQNPHFHDHSEHTGKERGRGKEHRRDSGIASPRTPRDVEIQVTPIPSPVHNGSDGKDDATSSGTPESIESSGSDVTETTEDDLEELNRRTHLPRDHPARKLLPIDLMFLVDTSSSIGINNFDIQKNFICEILKDVDIAPGRSRIAMIQYSQDPSVVFGFDQYYSYESVRRGVMRLSYTGGATMLSKALAFAGGIMYHEQNLKKTTKKHQYLPTPKHDRLQVLCLVSDGYSDDNADKESVNLHDHLHVKIFAVVTRSFNKDKLAPITRFDGSVFTVHQRESVAIWLWRQQRIWAEHYSAFIEKEKKRGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C364</accession>
    <name>A0A2C9C364_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein HIRA-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">hira-1</name>
        <name evidence="8" type="ORF">CELE_K10D2.1</name>
        <name evidence="10" type="ORF">K10D2.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SOF58793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343798.1">
        <property type="nucleotide sequence ID" value="NM_001356742.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C364"/>
    <dbReference type="SMR" id="A0A2C9C364"/>
    <dbReference type="GeneID" id="175709"/>
    <dbReference type="AGR" id="WB:WBGene00019627"/>
    <dbReference type="CTD" id="175709"/>
    <dbReference type="WormBase" id="K10D2.1c">
        <property type="protein sequence ID" value="CE52272"/>
        <property type="gene ID" value="WBGene00019627"/>
        <property type="gene designation" value="hira-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019627">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C364">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="7">
        <location>
            <begin position="256"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SOF58793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="K10D2.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C364"/>
        </source>
    </evidence>
    <sequence length="496" mass="54532" checksum="CF0C230386AB528A" modified="2017-12-20" version="1">MEDNSKENESKNSEKTMMEERNKQIDVRKDGKRRIQPVFCGTTTADPMTSLSSEGKKTVAPPPAKRKALAPAVPAKKGEVDLEDSSDSDDDDEEEEEDMEISDIESVRNKKRKVPATTSQPMLALDLKKPALRPMEPKSLKTQEGTVLMEAPEQQPKLSQHVVDRKGMFVEIDNRWKHGGVETTQIKLIKKKQQTAENEDDMMDGERRVNHECLWMAVLGSPVIIVAANKHNVVLGCGDKCLRVYRTFCGTHIVSLRLDSLPVLIGVTEHAAYALTENGRLSTWNLKLGKAVVTRQPLFDCVEASTDNSLISADVSETGVPLIVFSNGSIFTFNVSLSCWIQAITTNVLGRLTSPISDAQLSCSNGTTNSAGPLVRLLKRMRKQATAPGVAPQVVKAVKESQLEQLLHCAEQLGNPQDYQTMLMLYVETLCEGGSEKKLKNILNDLSRSGAPMQVCGLRRSALYDDVTRMIKLKQPAIAARIVAGVAASTTTKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C365</accession>
    <name>A0A2C9C365_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Muscle M-line assembly protein unc-89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">unc-89</name>
        <name evidence="18" type="ORF">C09D1.1</name>
        <name evidence="16" type="ORF">CELE_C09D1.1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">A band</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SOF58708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343718.1">
        <property type="nucleotide sequence ID" value="NM_001356810.3"/>
    </dbReference>
    <dbReference type="GeneID" id="171990"/>
    <dbReference type="AGR" id="WB:WBGene00006820"/>
    <dbReference type="CTD" id="171990"/>
    <dbReference type="WormBase" id="C09D1.1o">
        <property type="protein sequence ID" value="CE52289"/>
        <property type="gene ID" value="WBGene00006820"/>
        <property type="gene designation" value="unc-89"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006820">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C365">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SOF58708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="C09D1.1o"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C365"/>
        </source>
    </evidence>
    <sequence length="5912" mass="652858" checksum="3B5FDBF2248E989C" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C366</accession>
    <name>A0A2C9C366_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M16 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ucr-1</name>
        <name evidence="4" type="ORF">CELE_F56D2.1</name>
        <name evidence="6" type="ORF">F56D2.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="SOF58788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368666.1">
        <property type="nucleotide sequence ID" value="NM_001379717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C366"/>
    <dbReference type="SMR" id="A0A2C9C366"/>
    <dbReference type="GeneID" id="175772"/>
    <dbReference type="AGR" id="WB:WBGene00018963"/>
    <dbReference type="CTD" id="175772"/>
    <dbReference type="WormBase" id="F56D2.1b">
        <property type="protein sequence ID" value="CE52091"/>
        <property type="gene ID" value="WBGene00018963"/>
        <property type="gene designation" value="ucr-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018963">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C366">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF143">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="25"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SOF58788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F56D2.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C366"/>
        </source>
    </evidence>
    <sequence length="296" mass="32903" checksum="1A2D839C56C54A7F" modified="2017-12-20" version="1">MLHAAGFQGTPLALSVLGTSESIPNISAQQLKEWQEDHYRPVRMVLSAVGGGVSNVSSLADKYFGDLSNEYPRKVPQVDGTRFTGSEYRYRNDNVPHMYAAFAVEGVGYAHKDALALQIANQFIGQWDVTHATSRTAASRLVQKIGHDHGVHNLQHFNINYKDTGLFGIYFVADAHDLNDTSGIMKSVAHEWKHLASAATEEEVAMAKNQFRTNLYQNLETNTQKAGFNAKELLYTGNLRQLSELEAQIQKVDAGAVREAISRHVYDRDLAAVGVGRTEAFPNYALTRAGMSWWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C368</accession>
    <name>A0A2C9C368_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_H04M03.12</name>
        <name evidence="2 4" type="ORF">H04M03.12</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="SOF58794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C368"/>
    <dbReference type="PaxDb" id="6239-H04M03.12"/>
    <dbReference type="AGR" id="WB:WBGene00019156"/>
    <dbReference type="WormBase" id="H04M03.12b">
        <property type="protein sequence ID" value="CE52288"/>
        <property type="gene ID" value="WBGene00019156"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SXQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5856034at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019156">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C368">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="H04M03.12b"/>
        </source>
    </evidence>
    <sequence length="238" mass="27471" checksum="4A178092738BAA2F" modified="2017-12-20" version="1">MPDLMDRRATSASIPTNSKSSVKPLPIPKLSEGGTPIESALKSKRFSLVHMPSKQERRVTIRPYESFRERKEDKKDSITFGYAALSTNEDESRRDLEMEDGRPVSPSPSIFSIYGDEPGPSTICEQPVGAQADVFIASLGEKKLNQIKKYLDSTPREEHMYFLWVKDTECNKITVISIKTLENHLKNDSRVRRVKWRHLSSERVSIYRYSLPAITYEMSFIKFIIQEISKLQRFFNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C369</accession>
    <name>A0A2C9C369_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">acdh-2</name>
        <name evidence="8" type="ORF">C17C3.12</name>
        <name evidence="6" type="ORF">CELE_C17C3.12</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="SOF58733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380222.1">
        <property type="nucleotide sequence ID" value="NM_001393074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C369"/>
    <dbReference type="SMR" id="A0A2C9C369"/>
    <dbReference type="GeneID" id="173940"/>
    <dbReference type="AGR" id="WB:WBGene00015894"/>
    <dbReference type="CTD" id="173940"/>
    <dbReference type="WormBase" id="C17C3.12d">
        <property type="protein sequence ID" value="CE52312"/>
        <property type="gene ID" value="WBGene00015894"/>
        <property type="gene designation" value="acdh-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015894">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C369">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000026">
        <property type="entry name" value="Acyl-CoA dehydrogenase medium chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF6">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SOF58733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="C17C3.12d"/>
        </source>
    </evidence>
    <sequence length="171" mass="19612" checksum="5112C3DAFED3119A" modified="2017-12-20" version="1">MFKVPRKLPISAISTFSTTGSISAQQQPRVFPLQHLNENEKKLVEKVKNFAQSSVKPLVREMDRDARINKQLLKKAFDLKLMGLKIDPKYGGSGVSFFELVLAVEELSKIDPAIALIMHLQNALVAPLIEEFGWRLRTFGSCIWIRCIRNANSRQKRWRPLHSQRIKMGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C370</accession>
    <name>A0A2C9C370_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Ryanodine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">unc-68</name>
        <name evidence="20" type="ORF">CELE_K11C4.5</name>
        <name evidence="22" type="ORF">K11C4.5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="WBGene00006801"/>
        <property type="gene designation" value="unc-68"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300855at2759"/>
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    </dbReference>
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        <property type="entry name" value="Ryan_recept"/>
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        <property type="entry name" value="Ryanodine_IP3_receptor"/>
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        <property type="entry name" value="Ryanrecept_TM4-6"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <sequence length="5070" mass="576290" checksum="EA243A4995AB968F" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C375</accession>
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        <submittedName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase 1</fullName>
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        <name evidence="8 10" type="ORF">H14N18.4</name>
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    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C375"/>
    <dbReference type="SMR" id="A0A2C9C375"/>
    <dbReference type="AGR" id="WB:WBGene00019204"/>
    <dbReference type="WormBase" id="H14N18.4d">
        <property type="protein sequence ID" value="CE52224"/>
        <property type="gene ID" value="WBGene00019204"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019204">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C375">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000005">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000006">
        <property type="entry name" value="Protein CBG05566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF46">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="492"/>
            <end position="493"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SOF58853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="H14N18.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C375"/>
        </source>
    </evidence>
    <sequence length="614" mass="67231" checksum="F4DE75F56D762722" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C376</accession>
    <name>A0A2C9C376_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein kinase par-1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">par-1</name>
        <name evidence="17" type="ORF">CELE_H39E23.1</name>
        <name evidence="19" type="ORF">H39E23.1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="SOF58805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380226.1">
        <property type="nucleotide sequence ID" value="NM_001392649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C376"/>
    <dbReference type="SMR" id="A0A2C9C376"/>
    <dbReference type="GeneID" id="179912"/>
    <dbReference type="AGR" id="WB:WBGene00003916"/>
    <dbReference type="CTD" id="2768852"/>
    <dbReference type="WormBase" id="H39E23.1m">
        <property type="protein sequence ID" value="CE52350"/>
        <property type="gene ID" value="WBGene00003916"/>
        <property type="gene designation" value="par-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003916">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C376">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14072">
        <property type="entry name" value="STKc_MARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14337">
        <property type="entry name" value="UBA_MARK_Par1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001032">
        <property type="entry name" value="KP78b, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049508">
        <property type="entry name" value="MARK1-4_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="269"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="539"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="29"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="657"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="747"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="826"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="947"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1101"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="205"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="624"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="657"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1118"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="SOF58805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="H39E23.1m"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C376"/>
        </source>
    </evidence>
    <sequence length="1129" mass="121664" checksum="E10CEEB8D350CA8C" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C378</accession>
    <name>A0A2C9C378_CAEEL</name>
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        <recommendedName>
            <fullName evidence="10">Mechanosensory protein 3</fullName>
        </recommendedName>
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        <name evidence="16 18" type="primary">mec-3</name>
        <name evidence="16" type="ORF">CELE_F01D4.6</name>
        <name evidence="18" type="ORF">F01D4.6</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="SOF58798.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="NP_001343802.1">
        <property type="nucleotide sequence ID" value="NM_001356932.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C378"/>
    <dbReference type="SMR" id="A0A2C9C378"/>
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    <dbReference type="AGR" id="WB:WBGene00003167"/>
    <dbReference type="CTD" id="177938"/>
    <dbReference type="WormBase" id="F01D4.6d">
        <property type="protein sequence ID" value="CE52302"/>
        <property type="gene ID" value="WBGene00003167"/>
        <property type="gene designation" value="mec-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
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    </dbReference>
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    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="70"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="198"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
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            <begin position="200"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="SOF58798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="F01D4.6d"/>
        </source>
    </evidence>
    <sequence length="304" mass="34907" checksum="2641759BFCABBDA4" modified="2017-12-20" version="1">MEMLESKPLSAISMVIDSIGVDHENQMDNRSYHENCVKCTICESPLAEKCFWKNGRIYCSQHYYKDHSIHRCAGCKKGVSPTDMVYKLKAGLVFHVECHCCSLCGRHLSPGEQILVDDTMMTVSCMSHYPPQMDDNAPGAIGSAVDIPSCSTENPIAPYPIDESFSSAFQVKKEVDAYGYNFEHYSFSDFCDDDSRMLKRRGPRTTIKQNQLDVLNEMFSNTPKPSKHARAKLALETGLSMRVIQVWFQNRRSKERRLKHLCNYLRHYEQRGLIPPPIHFRNEEMDTTDFNAFCGNFEEEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C379</accession>
    <name>A0A2C9C379_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-related protein Rab-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">unc-108</name>
        <name evidence="2" type="ORF">CELE_F53F10.4</name>
        <name evidence="4" type="ORF">F53F10.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="SOF58718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001343727.1">
        <property type="nucleotide sequence ID" value="NM_001356806.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2C9C379"/>
    <dbReference type="SMR" id="A0A2C9C379"/>
    <dbReference type="GeneID" id="171956"/>
    <dbReference type="AGR" id="WB:WBGene00006833"/>
    <dbReference type="CTD" id="171956"/>
    <dbReference type="WormBase" id="F53F10.4d">
        <property type="protein sequence ID" value="CE52173"/>
        <property type="gene ID" value="WBGene00006833"/>
        <property type="gene designation" value="unc-108"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006833">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A2C9C379">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SOF58718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F53F10.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C379"/>
        </source>
    </evidence>
    <sequence length="69" mass="6996" checksum="329EA42F666AD64C" modified="2017-12-20" version="1">METSAKTAANVEEAFIDTAKEIYRKIQEGVFDINNEANGIKLGPQHSPSSPNSPGGNATGGLGGGSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C384</accession>
    <name>A0A2C9C384_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Ryanodine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">unc-68</name>
        <name evidence="20" type="ORF">CELE_K11C4.5</name>
        <name evidence="22" type="ORF">K11C4.5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C384"/>
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    </evidence>
    <sequence length="5200" mass="590824" checksum="34FC520F1E497953" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C388</accession>
    <name>A0A2C9C388_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Ryanodine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">unc-68</name>
        <name evidence="20" type="ORF">CELE_K11C4.5</name>
        <name evidence="22" type="ORF">K11C4.5</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
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        <location>
            <begin position="4449"/>
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        <location>
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        <location>
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        <location>
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        <location>
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    </feature>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50919"/>
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        <source>
            <dbReference type="EMBL" id="SOF58815.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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        <source>
            <dbReference type="WormBase" id="K11C4.5n"/>
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    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="A0A2C9C388"/>
        </source>
    </evidence>
    <sequence length="5084" mass="578041" checksum="54FAA98E225F6569" modified="2017-12-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C389</accession>
    <name>A0A2C9C389_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_W07A12.4</name>
        <name evidence="2 4" type="ORF">W07A12.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
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            <begin position="45"/>
            <end position="113"/>
        </location>
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    <sequence length="448" mass="52496" checksum="A3361016410CF4BE" modified="2017-12-20" version="1">MKLSSFEFISIENRKISDHKGSDWFGDDRETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDELCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFAQSEILPVIDLKELFSVWFSYATKAYHPSLIKSCMQAIALEFETLLTEEWEKDWQELHRDQMIEILKCNNLKVASEFKLWEALQKWIQAPNHSERRGNTAGPLLAFLLPLIRFPFMNGDELNEVEKSAISEMHPKLFQPPLLLSYKFNALPLSSRMSCKDFTKKQFLLRQYEDNRWNQRMTVAKTLLAYPCVDHAFTFTSRSSTVPMTEWKWTLKLTGLTFPNPTKVDVLRIILIAEGIDQYRSIEYMLQIVDEKKVLLSMSGKKTFTKTRYYAELEMEKQISFDELLHDDSTFSCNGEFIFQLFLRVIE</sequence>
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<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2C9C390</accession>
    <name>A0A2C9C390_CAEEL</name>
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        <submittedName>
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    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="entry name" value="RYANODINER"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4437"/>
            <end position="4460"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4623"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4686"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4824"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4866"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4951"/>
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        <location>
            <begin position="104"/>
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        <location>
            <begin position="582"/>
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        <location>
            <begin position="1006"/>
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        <location>
            <begin position="1477"/>
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        <location>
            <begin position="4183"/>
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        <location>
            <begin position="1328"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="VDJ65108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P6P9A6"/>
    <dbReference type="AGR" id="WB:WBGene00009172"/>
    <dbReference type="WormBase" id="F26F2.7d">
        <property type="protein sequence ID" value="CE52844"/>
        <property type="gene ID" value="WBGene00009172"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3P6P9A6">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDJ65108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F26F2.7d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A3P6P9A6"/>
        </source>
    </evidence>
    <sequence length="368" mass="41685" checksum="7E3DEEA53F4CD89E" modified="2019-02-13" version="1">MMSNNFVELKGSVFKKFAKANLFQMACSDVRERFHIFALLFVVMIRNMTAVNWNIDSFTEMIPDIIMVVGCEYFVDWLKHAFITKFNEINAEVYKDFTITIAFDVIRSRDQSAFSDYSDQVSRRMGFIPIPLSIMIIRVLSQTFTLDNWGSCIIFGIGWLLVFAVKICNGVVMLGQACHHVKRFRDIQARAEFELFRKRMVEKKSKSAPNSPRMSLIDFTDVLHQPAAGKGFTVSDMLSQWEELQPSLLSSEIRRSTDRETAVSHLTARSDERTPRRAVSMAHIPRRDRSEPPPAPSMDQDPQLDTEDPVVTENNTNSNSEQASPVKKKTTAAPVTSSASTNTNATSSDELADVTAYKMPEQGVQRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P6P9B9</accession>
    <name>A0A3P6P9B9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SANT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">swsn-1</name>
        <name evidence="7" type="ORF">CELE_Y113G7B.23</name>
        <name evidence="9" type="ORF">Y113G7B.23</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="VDJ65118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380243.1">
        <property type="nucleotide sequence ID" value="NM_001392706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P6P9B9"/>
    <dbReference type="SMR" id="A0A3P6P9B9"/>
    <dbReference type="GeneID" id="180324"/>
    <dbReference type="AGR" id="WB:WBGene00004203"/>
    <dbReference type="CTD" id="180324"/>
    <dbReference type="WormBase" id="Y113G7B.23e">
        <property type="protein sequence ID" value="CE52923"/>
        <property type="gene ID" value="WBGene00004203"/>
        <property type="gene designation" value="swsn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A3P6P9B9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032448">
        <property type="entry name" value="SWIRM-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16498">
        <property type="entry name" value="SWIRM-assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SANT" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDJ65118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y113G7B.23e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="A0A3P6P9B9"/>
        </source>
    </evidence>
    <sequence length="519" mass="55554" checksum="40F556FD72795C31" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5E4LWH4</accession>
    <name>A0A5E4LWH4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rab-3-interacting molecule unc-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">unc-10</name>
        <name evidence="13" type="ORF">CELE_T10A3.1</name>
        <name evidence="15" type="ORF">T10A3.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VVC12381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001362126.1">
        <property type="nucleotide sequence ID" value="NM_001375065.2"/>
    </dbReference>
    <dbReference type="SMR" id="A0A5E4LWH4"/>
    <dbReference type="GeneID" id="180990"/>
    <dbReference type="AGR" id="WB:WBGene00006750"/>
    <dbReference type="CTD" id="180990"/>
    <dbReference type="WormBase" id="T10A3.1d">
        <property type="protein sequence ID" value="CE53668"/>
        <property type="gene ID" value="WBGene00006750"/>
        <property type="gene designation" value="unc-10"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420032at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A5E4LWH4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04031">
        <property type="entry name" value="C2A_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04028">
        <property type="entry name" value="C2B_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06714">
        <property type="entry name" value="PDZ_RIM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000324">
        <property type="entry name" value="Rab-3-interacting molecule unc-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000780">
        <property type="entry name" value="Rab-3-interacting molecule unc-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000228">
        <property type="entry name" value="Rab3 interacting molecule, isoform R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000001">
        <property type="entry name" value="Regulating synaptic membrane exocytosis 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054386">
        <property type="entry name" value="RIM_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF21">
        <property type="entry name" value="RAB3 INTERACTING MOLECULE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
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        <source>
            <dbReference type="WormBase" id="T10E10.3c"/>
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    <sequence length="381" mass="43633" checksum="43E2847EEF32EF0F" modified="2019-11-13" version="1">MFPFLAILGVFGNSITLFVLLSRSMRNSTNEMLAAAAFSDILYIICMVPNQLSRWPSMVLSDCPDNPERKCASEYHMWFAVHKHHLAFLANWFSAASTWFIVTVSFDRLYAIKAPFSARLQTICPRHNLVAIPLILFFTGASCFHMNFKLLDDHAGSGNFTNSTMENIEDNRITLIQVMTVFMFIFHILIPMILLISFHTCLLYYLRNRFRHFFPARTRSARNSTRSDDVPAPLLSNVTDRSEVVRHHSSNSGVWNRHVNKAERHVTYTVIAIVTCYIVSHIPSACLYVYINLFHNVLYSTRWMYTSVQVSTTVVTCSKVANFILFCMSSKHFRKEMKKKLCFLSCKYKDGISGKDSANQPRTRSLPLNIIGDSSNNCSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8D9I637</accession>
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        <submittedName>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">Bristol N2</strain>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG8860239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T27D12.2f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="A0A8D9I637"/>
        </source>
    </evidence>
    <sequence length="850" mass="95154" checksum="36A1E689F46CF0E8" modified="2022-01-19" version="1"> </sequence>
</entry>
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    <accession>A5HW96</accession>
    <name>A5HW96_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">CELE_Y43F8B.3</name>
        <name evidence="4 6" type="ORF">Y43F8B.3</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAN86638.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001129575.2"/>
    </dbReference>
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    <dbReference type="MEROPS" id="I02.955"/>
    <dbReference type="PeptideAtlas" id="A5HW96"/>
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    <dbReference type="UCSC" id="Y43F8B.3a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
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    <dbReference type="CTD" id="180277"/>
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        <property type="protein sequence ID" value="CE46723"/>
        <property type="gene ID" value="WBGene00012814"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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                <person name="Zhang P."/>
                <person name="Chen Y."/>
                <person name="Zhu X."/>
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                <person name="Zhang P."/>
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                <person name="Zhu X."/>
                <person name="Liu Y."/>
                <person name="Liu Y."/>
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                <person name="Xu N."/>
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                <person name="Mak H.Y."/>
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        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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        </isoform>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_001122510.1">
        <property type="nucleotide sequence ID" value="NM_001129038.4"/>
    </dbReference>
    <dbReference type="WormBase" id="T02E1.5c">
        <property type="protein sequence ID" value="CE41006"/>
        <property type="gene ID" value="WBGene00000967"/>
        <property type="gene designation" value="dhs-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="T02E1.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="T02E1.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="T02E1.5c"/>
        </source>
    </evidence>
    <sequence length="168" mass="18269" checksum="5F07388C6B4D8EF3" modified="2007-06-26" version="1">MVKTVSVNTNALFFTTKNFLPGMLESNKGHIVTIASMAGKCGVAGLVDYCASKHGAVGFNDSLASELYALKKDVKTTVVCPIYINTGMFDGIATKWPTLLPILSPEYVVDCIMEAVLTDRAFLAIPKFSYIFIALAGLLPTEVLNLYGDHFGITHSMDHFKGRQSRQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>B2MZD0-2</accession>
    <name>VPP4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform a of V-type proton ATPase 116 kDa subunit a 4</fullName>
            <shortName evidence="2">V-ATPase 116 kDa isoform a 4</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 6" type="primary">vha-7</name>
        <name evidence="6" type="ORF">C26H9A.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="33079" last="33085">
            <title>Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase. Cell-specific expression during development.</title>
            <authorList>
                <person name="Oka T."/>
                <person name="Toyomura T."/>
                <person name="Honjo K."/>
                <person name="Wada Y."/>
                <person name="Futai M."/>
            </authorList>
            <dbReference type="PubMed" id="11441002"/>
            <dbReference type="DOI" id="10.1074/jbc.M101652200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>B2MZD0-1</id>
            <name evidence="6">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>B2MZD0-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_061243"/>
        </isoform>
        <isoform>
            <id>B2MZD0-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_061244 VSP_061245"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001379242.1">
        <property type="nucleotide sequence ID" value="NM_001392419.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C26H9A.1a">
        <property type="protein sequence ID" value="CE30882"/>
        <property type="gene ID" value="WBGene00006916"/>
        <property type="gene designation" value="vha-7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="11441002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="BAB62293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C26H9A.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C26H9A.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C26H9A.1c"/>
        </source>
    </evidence>
    <sequence length="966" mass="110585" checksum="60E4E20FB4A12289" modified="2009-05-26" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>B2MZD0-3</accession>
    <name>VPP4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform c of V-type proton ATPase 116 kDa subunit a 4</fullName>
            <shortName evidence="2">V-ATPase 116 kDa isoform a 4</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 6" type="primary">vha-7</name>
        <name evidence="6" type="ORF">C26H9A.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="33079" last="33085">
            <title>Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase. Cell-specific expression during development.</title>
            <authorList>
                <person name="Oka T."/>
                <person name="Toyomura T."/>
                <person name="Honjo K."/>
                <person name="Wada Y."/>
                <person name="Futai M."/>
            </authorList>
            <dbReference type="PubMed" id="11441002"/>
            <dbReference type="DOI" id="10.1074/jbc.M101652200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>B2MZD0-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_061243"/>
        </isoform>
        <isoform>
            <id>B2MZD0-1</id>
            <name evidence="6">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>B2MZD0-3</id>
            <name evidence="7">c</name>
            <sequence type="described" ref="VSP_061244 VSP_061245"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001299937.1">
        <property type="nucleotide sequence ID" value="NM_001313008.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C26H9A.1c">
        <property type="protein sequence ID" value="CE50146"/>
        <property type="gene ID" value="WBGene00006916"/>
        <property type="gene designation" value="vha-7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="11441002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="BAB62293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C26H9A.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="C26H9A.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="C26H9A.1c"/>
        </source>
    </evidence>
    <sequence length="336" mass="38226" checksum="4F73FD333BC9AE61" modified="2009-05-26" version="2">MSSFSNVGFVPHDGENEEDAINLAPKSSESFPAEDSIFADGSPRHRTLFDSKKRFKLRPPLLASTPRVICRFQQASSGSSAPYFTREPTFQPIQEFIEMSEHFHDITENSQGYRFLNTKEPFSRHHSALHHPRLSFDVLPKVIDFSRRWIGRARDTLYRLSVAYSGQEELGIERARDELDDRREHINLSEIFGGSHSQENSCSSGGVFNLNFDKSIEDRQLSFENIDLDSTSPQSTNDVIWLRDMTTVSTISEPILHPSSKISFTSSSPSPQRNPKNEAQKNSSSKREETSMFRSDPMKLYQMILVKEAAFECVAEIGKHGNVQFVDVEFITGFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-02" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B3WFV0</accession>
    <name>B3WFV0_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CELE_F13G3.3</name>
        <name evidence="9 11" type="ORF">F13G3.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAQ76468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001129764.1">
        <property type="nucleotide sequence ID" value="NM_001136292.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B3WFV0"/>
    <dbReference type="PeptideAtlas" id="B3WFV0"/>
    <dbReference type="GeneID" id="172475"/>
    <dbReference type="AGR" id="WB:WBGene00008763"/>
    <dbReference type="CTD" id="172475"/>
    <dbReference type="WormBase" id="F13G3.3b">
        <property type="protein sequence ID" value="CE42750"/>
        <property type="gene ID" value="WBGene00008763"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028496_1_0_1"/>
    <dbReference type="OrthoDB" id="5809216at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008763">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="B3WFV0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052012">
        <property type="entry name" value="GTase_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN F13G3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAQ76468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F13G3.3b"/>
        </source>
    </evidence>
    <sequence length="404" mass="46519" checksum="1566A4B96ED6A4FB" modified="2008-09-02" version="1">MTSAELERVTIHDACKWIAMTATAKIVLNPSLLLVSLGGNHAPIPFEVVSSEPKPVVMCISPLFAAENWHNLLVSLHVYKIFGAHMHLYIRSIVSPMLEILRVYEQEGYATLKPWNRINLLNRDEQDFNPNLNVEFRSQAAAQTDCLLRYKESSEFVAFVDLDDLIIPRVADNYASEFRYLASEHPTVAYFTYSKENTRIKAYKRANVFSIEHVLRNIKHEQQTETGKMIAIPSKINNTWIHWPQKNLKKLAVKPEFNSITHLKHIELLDGLKSKNEEEPKYNPSTGLDNDKPLISNKNIKMIEKDFNRMSWKSSVRRHLRNLPINMTYSKLISDCYKQSYYAFHSANENHGMLCPGPERCDISNHKTRCWISVGEYHSTRDGKLINVHFAENADFALNDGCQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D3KFS3</accession>
    <name>D3KFS3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sarcospan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F44G4.6</name>
        <name evidence="2 4" type="ORF">F44G4.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CBJ25075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254190.1">
        <property type="nucleotide sequence ID" value="NM_001267261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3KFS3"/>
    <dbReference type="SMR" id="D3KFS3"/>
    <dbReference type="GeneID" id="185762"/>
    <dbReference type="KEGG" id="cel:CELE_F44G4.6"/>
    <dbReference type="AGR" id="WB:WBGene00009715"/>
    <dbReference type="CTD" id="185762"/>
    <dbReference type="WormBase" id="F44G4.6b">
        <property type="protein sequence ID" value="CE44477"/>
        <property type="gene ID" value="WBGene00009715"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5774298at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009715">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3KFS3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBJ25075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F44G4.6b"/>
        </source>
    </evidence>
    <sequence length="154" mass="17421" checksum="404D67727988C049" modified="2010-03-23" version="1">MQEGYSNLGRCLSIIHFLCGFFILMSGVGSNYLSHDPFSMSFAFIYILVSLICCVTTRNYDPLCLRMCAFLSFVMTVASAYLVYQHASQTEQVCLRKCVRTEDYFHTQLAIICGIQVLNCVISIVYSCLCLKKSPKNQAYDCVKMEPEELPVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>D3KFS6</accession>
    <name>D3KFS6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">p-GlycoProtein related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">pgp-4</name>
        <name evidence="15" type="ORF">CELE_F42E11.1</name>
        <name evidence="17" type="ORF">F42E11.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CBJ25073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257143.1">
        <property type="nucleotide sequence ID" value="NM_001270214.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3KFS6"/>
    <dbReference type="SMR" id="D3KFS6"/>
    <dbReference type="PeptideAtlas" id="D3KFS6"/>
    <dbReference type="GeneID" id="181327"/>
    <dbReference type="AGR" id="WB:WBGene00003998"/>
    <dbReference type="CTD" id="181327"/>
    <dbReference type="WormBase" id="F42E11.1b">
        <property type="protein sequence ID" value="CE03308"/>
        <property type="gene ID" value="WBGene00003998"/>
        <property type="gene designation" value="pgp-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003998">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3KFS6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000916">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001797">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000087">
        <property type="entry name" value="p-GlycoProtein related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000090">
        <property type="entry name" value="p-GlycoProtein related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="829"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="928"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="965"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="45"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="374"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="707"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBJ25073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="F42E11.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="D3KFS6"/>
        </source>
    </evidence>
    <sequence length="1266" mass="139907" checksum="0853FC2345ACC453" modified="2010-03-23" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>D3KFS9</accession>
    <name>D3KFS9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Girdin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">mtcl-1</name>
        <name evidence="5" type="synonym">tag-241</name>
        <name evidence="5" type="ORF">C34E11.3</name>
        <name evidence="3" type="ORF">CELE_C34E11.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CBJ25076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379512.1">
        <property type="nucleotide sequence ID" value="NM_001392852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3KFS9"/>
    <dbReference type="SMR" id="D3KFS9"/>
    <dbReference type="PeptideAtlas" id="D3KFS9"/>
    <dbReference type="GeneID" id="181360"/>
    <dbReference type="AGR" id="WB:WBGene00044079"/>
    <dbReference type="CTD" id="181360"/>
    <dbReference type="WormBase" id="C34E11.3c">
        <property type="protein sequence ID" value="CE44513"/>
        <property type="gene ID" value="WBGene00044079"/>
        <property type="gene designation" value="mtcl-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10036174at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044079">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3KFS9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049885">
        <property type="entry name" value="MTCL1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15742">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15742:SF5">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBJ25076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C34E11.3c"/>
        </source>
    </evidence>
    <sequence length="456" mass="51525" checksum="9C5D79416C35B6EA" modified="2010-03-23" version="1">MDRLNDKITEITAEKNRQKNEAQKTIRVLSEQIKVLEIEQKNLSQNKDSQQVVKEMIESERERLQQIVHLNELQKLTRKYRLSSIIDQLAYVSEATRKTSREAEPDGIRYIINQLTVLRDDEAANNLNPDERAGSVLGEKASNGYAPSISECGEGTYDNISQSSFSIRSVNSAPLRHAYRHANLPIPTTTASVSTTISETEPYYSKPEKLNIISNYTTKRSFSTESSNGFDKYGRPMRRGLYHEPSSSNNLSVPGRKTSNDEYSMSRAASFDNRSQFSEDEVTEDGRSSRPNSTGANILYRVRREELARGGQPSVKLMAKAFEAIDEPRTDKRGFFGIRKSRSVETTQNGKHSKFEEAANSALMHSLGQVEEGVSSNYATLPRGGRNPFKNMGSRLVERVRRSLSRSSRQSRDSDREDEIEVQVYKKPEKPISSPKKTKKKSAESKARKNSSNIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D3KFT0</accession>
    <name>D3KFT0_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Girdin</fullName>
        </submittedName>
    </protein>
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        <name evidence="3 5" type="primary">mtcl-1</name>
        <name evidence="5" type="synonym">tag-241</name>
        <name evidence="5" type="ORF">C34E11.3</name>
        <name evidence="3" type="ORF">CELE_C34E11.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CBJ25077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379513.1">
        <property type="nucleotide sequence ID" value="NM_001392853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3KFT0"/>
    <dbReference type="SMR" id="D3KFT0"/>
    <dbReference type="GeneID" id="181360"/>
    <dbReference type="AGR" id="WB:WBGene00044079"/>
    <dbReference type="CTD" id="181360"/>
    <dbReference type="WormBase" id="C34E11.3d">
        <property type="protein sequence ID" value="CE44490"/>
        <property type="gene ID" value="WBGene00044079"/>
        <property type="gene designation" value="mtcl-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002689_0_0_1"/>
    <dbReference type="OrthoDB" id="10036174at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044079">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3KFT0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049885">
        <property type="entry name" value="MTCL1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15742">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15742:SF5">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBJ25077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C34E11.3d"/>
        </source>
    </evidence>
    <sequence length="413" mass="46685" checksum="1EAEAB0CFACF54D1" modified="2010-03-23" version="1">MDRLNDKITEITAEKNRQKNEAQKTIRVLSEQIKVLEIEQKNLSQNKDSQQVVKEMIESERERLQQIVHLNELQKLTRKYRLSSIIDQLAYVSEATRKTSREAEPDGIRYIINQLTVLRDDEAANNLNPDERAGSVLGEKASNGYAPSISECGEGTYDNISQSSFSIRSVNSAPLRHAYSTESSNGFDKYGRPMRRGLYHEPSSSNNLSVPGRKTSNDEYSMSRAASFDNRSQFSEDEVTEDGRSSRPNSTGANILYRVRREELARGGQPSVKLMAKAFEAIDEPRTDKRGFFGIRKSRSVETTQNGKHSKFEEAANSALMHSLGQVEEGVSSNYATLPRGGRNPFKNMGSRLVERVRRSLSRSSRQSRDSDREDEIEVQVYKKPEKPISSPKKTKKKSAESKARKNSSNIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFK4</accession>
    <name>D7SFK4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">lgx-1</name>
        <name evidence="6" type="ORF">C54G7.3</name>
        <name evidence="4" type="ORF">CELE_C54G7.3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_741796.2">
        <property type="nucleotide sequence ID" value="NM_171690.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFK4"/>
    <dbReference type="PeptideAtlas" id="D7SFK4"/>
    <dbReference type="GeneID" id="180825"/>
    <dbReference type="AGR" id="WB:WBGene00002983"/>
    <dbReference type="CTD" id="180825"/>
    <dbReference type="WormBase" id="C54G7.3b">
        <property type="protein sequence ID" value="CE44845"/>
        <property type="gene ID" value="WBGene00002983"/>
        <property type="gene designation" value="lgx-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_267664_0_0_1"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002983">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFK4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF11">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003105901" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="541"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="586"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="634"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="725"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="827"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="936"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1084"/>
        </location>
    </feature>
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        <location>
            <begin position="152"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1187"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD67047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="C54G7.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="D7SFK4"/>
        </source>
    </evidence>
    <sequence length="1231" mass="131170" checksum="FC304D406EA171EC" modified="2010-08-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFK5</accession>
    <name>D7SFK5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flocculation protein FLO11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_F28E10.1</name>
        <name evidence="3 5" type="ORF">F28E10.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD69727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023152.2">
        <property type="nucleotide sequence ID" value="NM_001027981.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7SFK5"/>
    <dbReference type="SMR" id="D7SFK5"/>
    <dbReference type="GeneID" id="177223"/>
    <dbReference type="KEGG" id="cel:CELE_F28E10.1"/>
    <dbReference type="AGR" id="WB:WBGene00017900"/>
    <dbReference type="CTD" id="177223"/>
    <dbReference type="WormBase" id="F28E10.1a">
        <property type="protein sequence ID" value="CE44822"/>
        <property type="gene ID" value="WBGene00017900"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864201at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017900">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFK5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="949"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    </feature>
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        <location>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="WBGene00017900"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262834_0_0_1"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017900">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D7SFK7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1046"/>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1056"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="532"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD69729.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="F28E10.1b"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>D7SFL2</accession>
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        <name evidence="11 13" type="primary">ampd-1</name>
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    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AMP + H2O + H(+) = IMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="9"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_062572.5"/>
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    <dbReference type="AGR" id="WB:WBGene00016415"/>
    <dbReference type="CTD" id="173891"/>
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        <property type="protein sequence ID" value="CE44883"/>
        <property type="gene ID" value="WBGene00016415"/>
        <property type="gene designation" value="ampd-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1723809at2759"/>
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        <property type="reaction ID" value="UER00663"/>
    </dbReference>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016415">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
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    </dbReference>
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        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
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    </dbReference>
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        <property type="entry name" value="Metallo-dependent hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="A_DEAMINASE"/>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="1"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD65831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C34F11.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="D7SFL2"/>
        </source>
    </evidence>
    <sequence length="822" mass="94350" checksum="4BB3124EF147B0C8" modified="2010-08-10" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-09-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYU6-2</accession>
    <name>NPL41_CAEEL</name>
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        <recommendedName>
            <fullName evidence="4">Isoform a of Nuclear protein localization protein 4 homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">npl-4.1</name>
        <name evidence="3" type="ORF">F59E12.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2006" name="J. Struct. Biol." volume="156" first="41" last="49">
            <title>A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation.</title>
            <authorList>
                <person name="Mouysset J."/>
                <person name="Kaehler C."/>
                <person name="Hoppe T."/>
            </authorList>
            <dbReference type="PubMed" id="16647269"/>
            <dbReference type="DOI" id="10.1016/j.jsb.2006.02.015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH UFD-1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="12879" last="12884">
            <title>Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication.</title>
            <authorList>
                <person name="Mouysset J."/>
                <person name="Deichsel A."/>
                <person name="Moser S."/>
                <person name="Hoege C."/>
                <person name="Hyman A.A."/>
                <person name="Gartner A."/>
                <person name="Hoppe T."/>
            </authorList>
            <dbReference type="PubMed" id="18728180"/>
            <dbReference type="DOI" id="10.1073/pnas.0805944105"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2009" name="J. Cell Sci." volume="122" first="3663" last="3672">
            <title>Caenorhabditis elegans p97 controls germline-specific sex determination by controlling the TRA-1 level in a CUL-2-dependent manner.</title>
            <authorList>
                <person name="Sasagawa Y."/>
                <person name="Otani M."/>
                <person name="Higashitani N."/>
                <person name="Higashitani A."/>
                <person name="Sato K."/>
                <person name="Ogura T."/>
                <person name="Yamanaka K."/>
            </authorList>
            <dbReference type="PubMed" id="19773360"/>
            <dbReference type="DOI" id="10.1242/jcs.052415"/>
        </citation>
        <scope>INTERACTION WITH ELC-1</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2010" name="Genes Cells" volume="15" first="1201" last="1215">
            <title>Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis.</title>
            <authorList>
                <person name="Sasagawa Y."/>
                <person name="Yamanaka K."/>
                <person name="Saito-Sasagawa Y."/>
                <person name="Ogura T."/>
            </authorList>
            <dbReference type="PubMed" id="20977550"/>
            <dbReference type="DOI" id="10.1111/j.1365-2443.2010.01454.x"/>
        </citation>
        <scope>IDENTIFICATION IN A COMPLEX WITH UBXN-3; UFD-1 AND CDC-48.1</scope>
        <scope>INTERACTION WITH UBXN-3 AND UFD-1</scope>
    </reference>
    <reference evidence="1" key="6">
        <citation type="journal article" date="2011" name="Mol. Cell" volume="44" first="85" last="96">
            <title>CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.</title>
            <authorList>
                <person name="Franz A."/>
                <person name="Orth M."/>
                <person name="Pirson P.A."/>
                <person name="Sonneville R."/>
                <person name="Blow J.J."/>
                <person name="Gartner A."/>
                <person name="Stemmann O."/>
                <person name="Hoppe T."/>
            </authorList>
            <dbReference type="PubMed" id="21981920"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2011.08.028"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="7">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E40145" last="E40145">
            <title>A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.</title>
            <authorList>
                <person name="Miedel M.T."/>
                <person name="Graf N.J."/>
                <person name="Stephen K.E."/>
                <person name="Long O.S."/>
                <person name="Pak S.C."/>
                <person name="Perlmutter D.H."/>
                <person name="Silverman G.A."/>
                <person name="Luke C.J."/>
            </authorList>
            <dbReference type="PubMed" id="22768338"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0040145"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="8">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="10612" last="10612">
            <title>Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.</title>
            <authorList>
                <person name="Franz A."/>
                <person name="Pirson P.A."/>
                <person name="Pilger D."/>
                <person name="Halder S."/>
                <person name="Achuthankutty D."/>
                <person name="Kashkar H."/>
                <person name="Ramadan K."/>
                <person name="Hoppe T."/>
            </authorList>
            <dbReference type="PubMed" id="26842564"/>
            <dbReference type="DOI" id="10.1038/ncomms10612"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="9">
        <citation type="journal article" date="2017" name="Nat. Cell Biol." volume="19" first="468" last="479">
            <title>CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.</title>
            <authorList>
                <person name="Sonneville R."/>
                <person name="Moreno S.P."/>
                <person name="Knebel A."/>
                <person name="Johnson C."/>
                <person name="Hastie C.J."/>
                <person name="Gartner A."/>
                <person name="Gambus A."/>
                <person name="Labib K."/>
            </authorList>
            <dbReference type="PubMed" id="28368371"/>
            <dbReference type="DOI" id="10.1038/ncb3500"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KYU6-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_059819"/>
        </isoform>
        <isoform>
            <id>H2KYU6-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001370453.1">
        <property type="nucleotide sequence ID" value="NM_001383846.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F59E12.4a">
        <property type="protein sequence ID" value="CE28572"/>
        <property type="gene ID" value="WBGene00019120"/>
        <property type="gene designation" value="npl-4.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F59E12.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F59E12.4b"/>
        </source>
    </evidence>
    <sequence length="527" mass="59393" checksum="5B0B95B0B80FB61F" modified="2012-03-21" version="1"> </sequence>
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<entry dataset="Swiss-Prot" created="2019-09-18" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>H2KZM9-2</accession>
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        <recommendedName>
            <fullName evidence="2">Isoform a of Tubulin polyglutamylase ttll-11</fullName>
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        <alternativeName>
            <fullName evidence="7">Tubulin--tyrosine ligase-like protein 11</fullName>
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    <gene>
        <name evidence="7" type="primary">ttll-11</name>
        <name evidence="7" type="ORF">H23L24.3</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2010" name="J. Biol. Chem." volume="285" first="22936" last="22941">
            <title>Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs).</title>
            <authorList>
                <person name="Kimura Y."/>
                <person name="Kurabe N."/>
                <person name="Ikegami K."/>
                <person name="Tsutsumi K."/>
                <person name="Konishi Y."/>
                <person name="Kaplan O.I."/>
                <person name="Kunitomo H."/>
                <person name="Iino Y."/>
                <person name="Blacque O.E."/>
                <person name="Setou M."/>
            </authorList>
            <dbReference type="PubMed" id="20519502"/>
            <dbReference type="DOI" id="10.1074/jbc.C110.128280"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2016" name="Biol. Open" volume="5" first="1290" last="1298">
            <title>Caenorhabditis elegans glutamylating enzymes function redundantly in male mating.</title>
            <authorList>
                <person name="Chawla D.G."/>
                <person name="Shah R.V."/>
                <person name="Barth Z.K."/>
                <person name="Lee J.D."/>
                <person name="Badecker K.E."/>
                <person name="Naik A."/>
                <person name="Brewster M.M."/>
                <person name="Salmon T.P."/>
                <person name="Peel N."/>
            </authorList>
            <dbReference type="PubMed" id="27635036"/>
            <dbReference type="DOI" id="10.1242/bio.017442"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 191-THR--LEU-707</scope>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="3430" last="3441.E6">
            <title>Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia.</title>
            <authorList>
                <person name="O'Hagan R."/>
                <person name="Silva M."/>
                <person name="Nguyen K.C.Q."/>
                <person name="Zhang W."/>
                <person name="Bellotti S."/>
                <person name="Ramadan Y.H."/>
                <person name="Hall D.H."/>
                <person name="Barr M.M."/>
            </authorList>
            <dbReference type="PubMed" id="29129530"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.09.066"/>
        </citation>
        <scope>FUNCTION (ISOFORMS A AND B)</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY (ISOFORMS A AND B)</scope>
        <scope>MUTAGENESIS OF 191-THR--LEU-707</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically promotes tubulin glutamylation in a subset of ciliated neurons including amphid, phasmid, CEP and RnA neurons.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KZM9-2</id>
            <name evidence="6">a</name>
            <sequence type="described" ref="VSP_060273"/>
        </isoform>
        <isoform>
            <id>H2KZM9-1</id>
            <name evidence="7">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="6.-.-.-" evidence="3 4"/>
    <dbReference type="RefSeq" id="NP_001367737.1">
        <property type="nucleotide sequence ID" value="NM_001380378.1"/>
    </dbReference>
    <dbReference type="WormBase" id="H23L24.3a">
        <property type="protein sequence ID" value="CE31706"/>
        <property type="gene ID" value="WBGene00019230"/>
        <property type="gene designation" value="ttll-11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="29129530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="27635036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="29129530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="H23L24.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="H23L24.3b"/>
        </source>
    </evidence>
    <sequence length="607" mass="69786" checksum="F32AC5CA7B91555A" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>O17322</accession>
    <name>O17322_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_D1079.1</name>
        <name evidence="2 4" type="ORF">D1079.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD68408.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_508758.2">
        <property type="nucleotide sequence ID" value="NM_076357.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O17322"/>
    <dbReference type="SMR" id="O17322"/>
    <dbReference type="PaxDb" id="6239-D1079.1"/>
    <dbReference type="GeneID" id="183926"/>
    <dbReference type="UCSC" id="D1079.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017040"/>
    <dbReference type="CTD" id="183926"/>
    <dbReference type="WormBase" id="D1079.1a">
        <property type="protein sequence ID" value="CE47131"/>
        <property type="gene ID" value="WBGene00017040"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TFUV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091468_0_0_1"/>
    <dbReference type="OMA" id="WIHFENV"/>
    <dbReference type="OrthoDB" id="5870289at2759"/>
    <dbReference type="PhylomeDB" id="O17322"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017040">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="O17322">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF15">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD68408.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="D1079.1a"/>
        </source>
    </evidence>
    <sequence length="266" mass="30378" checksum="46F9C165F415B0DE" modified="2012-05-16" version="2">MESDSSNYTLCDDTSQVRIAFFSIGTCLSALGCVFNGVLLYIFLGKTQRSYPFQTFLAFLDFMLCALYIHCFGLLSISVEYKIAFLYNFVMDSNVVTLVMSRIVQLSIPYTLIANSAEKLTMILGIDCESQFSLRLRIGVILLLLGTATSLRINGLYLYFIDEDENCDFYHRKWLSSHQEEQAKWIHFENVLTFFHTFVSFVLLCALNIVVVAKLRVQHRKTRRQSTSPAQLFSVYFRNFLGSKSITVLTPVGNTTTQTLETRVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2026-01-28" version="187" xmlns="https://uniprot.org/uniprot">
    <accession>O18688</accession>
    <name>O18688_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">tba-1</name>
        <name evidence="15" type="ORF">CELE_F26E4.8</name>
        <name evidence="17" type="ORF">F26E4.8</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAB03001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21415">
        <property type="entry name" value="T21415"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379189.1">
        <property type="nucleotide sequence ID" value="NM_001392888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O18688"/>
    <dbReference type="SMR" id="O18688"/>
    <dbReference type="DIP" id="DIP-25114N"/>
    <dbReference type="IntAct" id="O18688">
        <property type="interactions" value="1"/>
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        <property type="entry name" value="TUBULIN"/>
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    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
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            <end position="391"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="O18688"/>
        </source>
    </evidence>
    <sequence length="449" mass="50009" checksum="991D292EDC04BDB2" modified="1998-01-01" version="1">MREVISIHVGQAGVQIGNACWELYCLEHGIQPDGTMPSDQQADGESFTTFFSDTGNGRYVPRSIFVDLEPTVVDEIRTGTYKKLFHPEQMITGKEDAANNYARGHYTVGKELIDTVLDRIRRLADNCSGLQGFFVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLSVDRPSYTNLNRIISQVVSSITASLRFDGALNVDLNEFQTNLVPYPRIHFPLAAYTPLISADKAYHEALSVNDITNSCFEPANQMVKCDPRHGKYMAVCLLYRGDVVPKDVNTAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVPRAVCMLSNTTAIAEAWSRLDYKFDLMYAKRAFVHWYVGEGMEEGEFTEAREDLAALEKDYEEVGADSNEGGNEEEGEEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>P34481-2</accession>
    <name>PS11B_CAEEL</name>
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        <recommendedName>
            <fullName>Isoform b of Probable 26S proteasome regulatory subunit rpn-6.2</fullName>
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    <gene>
        <name type="primary">rpn-6.2</name>
        <name type="ORF">F59B2.5</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34481-1</id>
            <name>a</name>
            <sequence type="displayed"/>
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        <isoform>
            <id>P34481-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_039826"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001254973.1">
        <property type="nucleotide sequence ID" value="NM_001268044.3"/>
    </dbReference>
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        <property type="protein sequence ID" value="CE43486"/>
        <property type="gene ID" value="WBGene00010309"/>
        <property type="gene designation" value="rpn-6.2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="213" mass="24224" checksum="5AFB8F341A92D4B4" modified="2010-10-05" version="3">MQSGVLYSAEERDYKTSFSYFYEAFEGFASIGDKINATSALKYMILCKIMLNETEQLAGLLAAKEIVAYQKSPRIIAIRSMADAFRKRSLKDFVKALAEHKIELVEDKVVAVHSQNLERNMLEKEISRVIEPYSEIELSYIARVIGMTVPPVERAIARMILDKKLMGSIDQHGDTVVVYPKADAANQFTRSLKTIRELTKTVDVSYSRTKHFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>P90755-2</accession>
    <name>ENPP2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">C27A7.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P90755-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_020300"/>
        </isoform>
        <isoform>
            <id>P90755-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
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        <property type="nucleotide sequence ID" value="NM_001047623.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C27A7.3b">
        <property type="protein sequence ID" value="CE40021"/>
        <property type="gene ID" value="WBGene00007755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="713" mass="80981" checksum="14ED15F1CFAE7D06" modified="2006-01-24" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q10033-2</accession>
    <name>YSI1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Uncharacterized protein F15G9.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">F15G9.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q10033-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_002445"/>
        </isoform>
        <isoform>
            <id>Q10033-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001370065.1">
        <property type="nucleotide sequence ID" value="NM_001383628.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F15G9.1b">
        <property type="protein sequence ID" value="CE23660"/>
        <property type="gene ID" value="WBGene00008865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="205" mass="22337" checksum="C69183FD85698BE5" modified="1997-11-01" version="1">MDDYSAAPIAKDEIEELSYDAKTPTTPTEETVDAPREVLQESQISDFVEEDDDQQTEVEEVKLTLASEPEESEEEEDDEDVRKAQELLAASTQIRESSPVSSPVKEVSSAASLFANDNGNETENRTPSPTVLNAKKLGGIPWPPKSSDVKKEGGDAEALPKKRVSDLIARFNTGVVEESKKTDDAYKNEYGAGTNVGKVSTHNFA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>Q19706-2</accession>
    <name>EIF3G_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="1">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="1">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eif-3.G</name>
        <name evidence="2" type="ORF">F22B5.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Nature" volume="421" first="231" last="237">
            <title>Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.</title>
            <authorList>
                <person name="Kamath R.S."/>
                <person name="Fraser A.G."/>
                <person name="Dong Y."/>
                <person name="Poulin G."/>
                <person name="Durbin R."/>
                <person name="Gotta M."/>
                <person name="Kanapin A."/>
                <person name="Le Bot N."/>
                <person name="Moreno S."/>
                <person name="Sohrmann M."/>
                <person name="Welchman D.P."/>
                <person name="Zipperlen P."/>
                <person name="Ahringer J."/>
            </authorList>
            <dbReference type="PubMed" id="12529635"/>
            <dbReference type="DOI" id="10.1038/nature01278"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="Elife" volume="10" first="0" last="0">
            <title>Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.</title>
            <authorList>
                <person name="Blazie S.M."/>
                <person name="Takayanagi-Kiya S."/>
                <person name="McCulloch K.A."/>
                <person name="Jin Y."/>
            </authorList>
            <dbReference type="PubMed" id="34323215"/>
            <dbReference type="DOI" id="10.7554/elife.68336"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF CYS-127 AND CYS-130</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19706-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q19706-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_056763"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_495778.1">
        <property type="nucleotide sequence ID" value="NM_063377.5"/>
    </dbReference>
    <dbReference type="WormBase" id="F22B5.2b">
        <property type="protein sequence ID" value="CE02197"/>
        <property type="gene ID" value="WBGene00001230"/>
        <property type="gene designation" value="eif-3.G"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F22B5.2a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F22B5.2b"/>
        </source>
    </evidence>
    <sequence length="256" mass="29289" checksum="BEED1E4ADED2F33B" modified="2014-10-01" version="2">MAPAPEVVSWAEAVEQDNAPHIQEGADGTRTETAFTEVDGVRWKVVTQFKVINKRVPKVVADRKKWVKFGSCKGEPAGPQVATTYVAEEVDMQFTRNRAGEQILDVQEDKQTAKTTSREHCRHCKGNDHWSTHCPYKVMYQLDEEADADKDTEKDRMAMGMRPDGRQIDRNRSDENTCRVTNLPQEMNEDELRDLFGKIGRVIRIFIARDKVTGLPKGFAFVTFESRDDAARAIAELNDIRMYHMVLKVEWTRPSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-28" modified="2026-01-28" version="175" xmlns="https://uniprot.org/uniprot">
    <accession>Q20745-2</accession>
    <name>UNC84_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Nuclear migration and anchoring protein unc-84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Uncoordinated protein 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">unc-84</name>
        <name evidence="3" type="ORF">F54B11.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1999" name="Development" volume="126" first="3171" last="3181">
            <title>UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development.</title>
            <authorList>
                <person name="Malone C.J."/>
                <person name="Fixsen W.D."/>
                <person name="Horvitz H.R."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="10375507"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF 1-MET--ARG-208; 40-LEU--LYS-161; PRO-91; ASP-932; ARG-984; SER-988; CYS-994 AND GLY-1002</scope>
        <source>
            <strain>Bristol N2</strain>
            <tissue>Embryo</tissue>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Development" volume="128" first="5039" last="5050">
            <title>unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration.</title>
            <authorList>
                <person name="Starr D.A."/>
                <person name="Hermann G.J."/>
                <person name="Malone C.J."/>
                <person name="Fixsen W."/>
                <person name="Priess J.R."/>
                <person name="Horvitz H.R."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="11748140"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH UNC-83</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF 1-MET--ARG-208; PRO-91; ASP-932; ARG-984; SER-988 AND GLY-1002</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="J. Cell Sci." volume="115" first="923" last="929">
            <title>The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans.</title>
            <authorList>
                <person name="Gruenbaum Y."/>
                <person name="Lee K.K."/>
                <person name="Liu J."/>
                <person name="Cohen M."/>
                <person name="Wilson K.L."/>
            </authorList>
            <dbReference type="PubMed" id="11870211"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2002" name="Mol. Biol. Cell" volume="13" first="892" last="901">
            <title>Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Lee K.K."/>
                <person name="Starr D.A."/>
                <person name="Cohen M."/>
                <person name="Liu J."/>
                <person name="Han M."/>
                <person name="Wilson K.L."/>
                <person name="Gruenbaum Y."/>
            </authorList>
            <dbReference type="PubMed" id="11907270"/>
            <dbReference type="DOI" id="10.1091/mbc.01-06-0294"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF ASP-932; ARG-984; SER-988 AND GLY-1002</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2002" name="Science" volume="298" first="406" last="409">
            <title>Role of ANC-1 in tethering nuclei to the actin cytoskeleton.</title>
            <authorList>
                <person name="Starr D.A."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="12169658"/>
            <dbReference type="DOI" id="10.1126/science.1075119"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ANC-1</scope>
        <scope>MUTAGENESIS OF PRO-91 AND GLY-1002</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2006" name="Mol. Biol. Cell" volume="17" first="1790" last="1801">
            <title>UNC-83 IS a KASH protein required for nuclear migration and is recruited to the outer nuclear membrane by a physical interaction with the SUN protein UNC-84.</title>
            <authorList>
                <person name="McGee M.D."/>
                <person name="Rillo R."/>
                <person name="Anderson A.S."/>
                <person name="Starr D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481402"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-09-0894"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH UNC-83</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>TOPOLOGY</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2010" name="J. Cell Biol." volume="191" first="115" last="128">
            <title>Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei.</title>
            <authorList>
                <person name="Fridolfsson H.N."/>
                <person name="Starr D.A."/>
            </authorList>
            <dbReference type="PubMed" id="20921138"/>
            <dbReference type="DOI" id="10.1083/jcb.201004118"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2011" name="Dev. Biol." volume="357" first="356" last="369">
            <title>The branched actin nucleator Arp2/3 promotes nuclear migrations and cell polarity in the C. elegans zygote.</title>
            <authorList>
                <person name="Xiong H."/>
                <person name="Mohler W.A."/>
                <person name="Soto M.C."/>
            </authorList>
            <dbReference type="PubMed" id="21798253"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2011.07.008"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF CYS-994</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Mol. Biol. Cell" volume="22" first="1739" last="1752">
            <title>Multiple mechanisms actively target the SUN protein UNC-84 to the inner nuclear membrane.</title>
            <authorList>
                <person name="Tapley E.C."/>
                <person name="Ly N."/>
                <person name="Starr D.A."/>
            </authorList>
            <dbReference type="PubMed" id="21411627"/>
            <dbReference type="DOI" id="10.1091/mbc.E10-08-0733"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF 1-MET--ARG-208 AND 118-TYR--LEU-244</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2013" name="Genetics" volume="193" first="187" last="200">
            <title>toca-1 is in a novel pathway that functions in parallel with a SUN-KASH nuclear envelope bridge to move nuclei in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Chang Y.T."/>
                <person name="Dranow D."/>
                <person name="Kuhn J."/>
                <person name="Meyerzon M."/>
                <person name="Ngo M."/>
                <person name="Ratner D."/>
                <person name="Warltier K."/>
                <person name="Starr D.A."/>
            </authorList>
            <dbReference type="PubMed" id="23150597"/>
            <dbReference type="DOI" id="10.1534/genetics.112.146589"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2014" name="J. Cell Biol." volume="206" first="163" last="172">
            <title>The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architecture.</title>
            <authorList>
                <person name="Cain N.E."/>
                <person name="Tapley E.C."/>
                <person name="McDonald K.L."/>
                <person name="Cain B.M."/>
                <person name="Starr D.A."/>
            </authorList>
            <dbReference type="PubMed" id="25023515"/>
            <dbReference type="DOI" id="10.1083/jcb.201405081"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2014" name="Mol. Biol. Cell" volume="25" first="2853" last="2865">
            <title>The Caenorhabditis elegans SUN protein UNC-84 interacts with lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migration.</title>
            <authorList>
                <person name="Bone C.R."/>
                <person name="Tapley E.C."/>
                <person name="Gorjanacz M."/>
                <person name="Starr D.A."/>
            </authorList>
            <dbReference type="PubMed" id="25057012"/>
            <dbReference type="DOI" id="10.1091/mbc.E14-05-0971"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH LMN-1</scope>
        <scope>MUTAGENESIS OF 1-MET--ARG-208; 40-LEU--LYS-161 AND PRO-91</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2016" name="J. Cell Biol." volume="215" first="801" last="821">
            <title>LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining.</title>
            <authorList>
                <person name="Lawrence K.S."/>
                <person name="Tapley E.C."/>
                <person name="Cruz V.E."/>
                <person name="Li Q."/>
                <person name="Aung K."/>
                <person name="Hart K.C."/>
                <person name="Schwartz T.U."/>
                <person name="Starr D.A."/>
                <person name="Engebrecht J."/>
            </authorList>
            <dbReference type="PubMed" id="27956467"/>
            <dbReference type="DOI" id="10.1083/jcb.201604112"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ZYG-12</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF PRO-91; CYS-994 AND GLY-1002</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q20745-1</id>
            <name evidence="2">a</name>
            <name evidence="1">L</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q20745-2</id>
            <name evidence="3">b</name>
            <name evidence="1">S</name>
            <sequence type="described" ref="VSP_007081 VSP_007082"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001366990.1">
        <property type="nucleotide sequence ID" value="NM_001381134.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F54B11.3b">
        <property type="protein sequence ID" value="CE27761"/>
        <property type="gene ID" value="WBGene00006816"/>
        <property type="gene designation" value="unc-84"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="11907270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F54B11.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F54B11.3b"/>
        </source>
    </evidence>
    <sequence length="879" mass="99017" checksum="6EC7CDD6EA96C546" modified="2001-10-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q22133</accession>
    <name>Q22133_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Costars domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tag-243</name>
        <name evidence="3" type="ORF">CELE_T04A8.4</name>
        <name evidence="5" type="ORF">T04A8.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAA84722.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T24421">
        <property type="entry name" value="T24421"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379060.1">
        <property type="nucleotide sequence ID" value="NM_001393324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q22133"/>
    <dbReference type="SMR" id="Q22133"/>
    <dbReference type="PaxDb" id="6239-T04A8.4"/>
    <dbReference type="PeptideAtlas" id="Q22133"/>
    <dbReference type="GeneID" id="188039"/>
    <dbReference type="UCSC" id="T04A8.4">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Bristol N2</strain>
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    <reference evidence="1" key="2">
        <citation type="journal article" date="2003" name="Science" volume="301" first="1387" last="1391">
            <title>Autophagy genes are essential for dauer development and life-span extension in C. elegans.</title>
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            </authorList>
            <dbReference type="PubMed" id="12958363"/>
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        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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            <title>Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans.</title>
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                <person name="Takacs-Vellai K."/>
                <person name="Vellai T."/>
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            </authorList>
            <dbReference type="PubMed" id="16111945"/>
            <dbReference type="DOI" id="10.1016/j.cub.2005.07.035"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CED-9 AND VPS-34</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
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            <authorList>
                <person name="Hars E.S."/>
                <person name="Qi H."/>
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            <dbReference type="PubMed" id="17204841"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2007" name="Genetics" volume="177" first="655" last="660">
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                <person name="Aladzsity I."/>
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            <dbReference type="PubMed" id="17890369"/>
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        </citation>
        <scope>FUNCTION</scope>
    </reference>
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                <person name="Toth M.L."/>
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            </authorList>
            <dbReference type="PubMed" id="17327275"/>
            <dbReference type="DOI" id="10.1242/jcs.03401"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="7">
        <citation type="journal article" date="2009" name="Proc. Natl. Acad. Sci. U.S.A." volume="106" first="14564" last="14569">
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                <person name="Jia K."/>
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            <dbReference type="PubMed" id="19667176"/>
            <dbReference type="DOI" id="10.1073/pnas.0813319106"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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            <title>The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans.</title>
            <authorList>
                <person name="Ruck A."/>
                <person name="Attonito J."/>
                <person name="Garces K.T."/>
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            <dbReference type="PubMed" id="21183797"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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            <title>Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.</title>
            <authorList>
                <person name="Liu K."/>
                <person name="Jian Y."/>
                <person name="Sun X."/>
                <person name="Yang C."/>
                <person name="Gao Z."/>
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            <dbReference type="PubMed" id="26783301"/>
            <dbReference type="DOI" id="10.1083/jcb.201506081"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH VPS-34; SORF-1 AND SORF-2</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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            <title>Correction: Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.</title>
            <authorList>
                <person name="Liu K."/>
                <person name="Jian Y."/>
                <person name="Sun X."/>
                <person name="Yang C."/>
                <person name="Gao Z."/>
                <person name="Zhang Z."/>
                <person name="Liu X."/>
                <person name="Li Y."/>
                <person name="Xu J."/>
                <person name="Jing Y."/>
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                <person name="He S."/>
                <person name="Yang C."/>
            </authorList>
            <dbReference type="PubMed" id="26975852"/>
            <dbReference type="DOI" id="10.1083/jcb.20150608103012016c"/>
        </citation>
        <scope>ERRATUM OF PUBMED:26783301</scope>
    </reference>
    <reference key="11">
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            <title>A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development.</title>
            <authorList>
                <person name="Ames K."/>
                <person name="Da Cunha D.S."/>
                <person name="Gonzalez B."/>
                <person name="Konta M."/>
                <person name="Lin F."/>
                <person name="Shechter G."/>
                <person name="Starikov L."/>
                <person name="Wong S."/>
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                <person name="Melendez A."/>
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            <dbReference type="PubMed" id="28285998"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.02.015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
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        <event type="alternative splicing"/>
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            <id>Q22592-2</id>
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            <id>Q22592-1</id>
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    <sequence length="118" mass="13219" checksum="3EE6A8FC1BD899EA" modified="2001-10-01" version="2">MPVAMGSHSYIKLRRNGIDMETYALYGQGTPLSGSSGIDPGIRRFLQLLEFLLKELKDRNKNFKPPYQIHADSLVDNGVKYNAVMTLNTDVRWTRAMALMLTDLKAACAQCDALRSPI</sequence>
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    <accession>Q23229-3</accession>
    <name>XOL1_CAEEL</name>
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        <recommendedName>
            <fullName>Isoform c of XO lethal protein 1</fullName>
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    <reference key="1">
        <citation type="journal article" date="1988" name="Cell" volume="55" first="167" last="183">
            <title>xol-1: a gene that controls the male modes of both sex determination and X chromosome dosage compensation in C. elegans.</title>
            <authorList>
                <person name="Miller L.M."/>
                <person name="Plenefisch J.D."/>
                <person name="Casson L.P."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="3167975"/>
            <dbReference type="DOI" id="10.1016/0092-8674(88)90019-0"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1994" name="Development" volume="120" first="3681" last="3689">
            <title>Identification of a candidate primary sex determination locus, fox-1, on the X chromosome of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hodgkin J."/>
                <person name="Zellan J.D."/>
                <person name="Albertson D.G."/>
            </authorList>
            <dbReference type="PubMed" id="7821230"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1995" name="Cell" volume="80" first="71" last="82">
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            <authorList>
                <person name="Rhind N.R."/>
                <person name="Miller L.M."/>
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                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="7813020"/>
            <dbReference type="DOI" id="10.1016/0092-8674(95)90452-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS B AND C)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="4">
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            <title>X-chromosome-counting mechanisms that determine nematode sex.</title>
            <authorList>
                <person name="Nicoll M."/>
                <person name="Akerib C.C."/>
                <person name="Meyer B.J."/>
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            <dbReference type="PubMed" id="9217163"/>
            <dbReference type="DOI" id="10.1038/40645"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
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            <title>The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex.</title>
            <authorList>
                <person name="Carmi I."/>
                <person name="Kopczynski J.B."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="9823896"/>
            <dbReference type="DOI" id="10.1038/24164"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
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            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="7">
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                <person name="Skipper M."/>
                <person name="Milne C.A."/>
                <person name="Hodgkin J."/>
            </authorList>
            <dbReference type="PubMed" id="9927456"/>
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        <scope>INDUCTION</scope>
    </reference>
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            <authorList>
                <person name="Luz J.G."/>
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            <dbReference type="PubMed" id="12672694"/>
            <dbReference type="DOI" id="10.1101/gad.1082303"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS)</scope>
        <scope>LACK OF ATP-BINDING</scope>
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            <authorList>
                <person name="Farboud B."/>
                <person name="Novak C.S."/>
                <person name="Nicoll M."/>
                <person name="Quiogue A."/>
                <person name="Meyer B.J."/>
            </authorList>
            <dbReference type="PubMed" id="33372658"/>
            <dbReference type="DOI" id="10.7554/elife.62963"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q23229-1</id>
            <name evidence="3">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q23229-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_016414"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1 2">Inactive isoform (PubMed:33372658, PubMed:7813020). Produced by alternative splicing of intron 6 which results in the retention of intron 6 and deletion of exon 7 coding sequences (PubMed:33372658). An in-frame UAA stop codon within intron 6 prematurely terminates translation (PubMed:7813020). Intron 6 retention and exon 7 deletion can also be due to use of an alternative 3' splice acceptor site in the 3'UTR resulting in trans-splicing to the transcripts of unrelated genes (PubMed:33372658).</text>
    </comment>
    <dbReference type="RefSeq" id="NP_001024419.1">
        <property type="nucleotide sequence ID" value="NM_001029248.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C18A11.5c">
        <property type="protein sequence ID" value="CE24807"/>
        <property type="gene ID" value="WBGene00006962"/>
        <property type="gene designation" value="xol-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="33372658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="7813020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C18A11.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C18A11.5c"/>
        </source>
    </evidence>
    <sequence length="426" mass="48423" checksum="90CC20EF32512EC0" modified="1996-11-01" version="1">MQVEANSERRVKILGIDRSENSPVLTYMETEDDPNFRNSKLAAAPHTVHMMDSGFLAINRQCLVKGKAILAREPKSSNEHMIDDLPKHAHDQHTLSILRDFIDQLKLHNVYEINFYDPLDSSGKLAVIPMLIALWKCMLASETDICDQEVLKSIMNSVIAKFELQIPCKNAVIDATLSGSREEVHIIAEDGSLENSNGTTEHFNKKHDLVFVKTDLHPEDFTPQMFPSQAKAKLLRDAFNNEEDEDTFPDILVPAYMTAHSKNRVRQEDYTCLEVEFDSQVALEKLMNEHEQVEGFEVQQGGILVALKKDSFFDDELIEKIAYSAQYYLSMTHFSNRISIPLFSSLVFLTVSIVINAMCHKSIFCKRVISRLPFPHCQILKLSHFSTGRTFLSYLSIIAKCTPISHINQSNILPAQNKIFAIKQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I100</accession>
    <name>Q8I100_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab5 GDP/GTP exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rabx-5</name>
        <name evidence="7" type="ORF">CELE_Y39A1A.5</name>
        <name evidence="9" type="ORF">Y39A1A.5</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-2655296">
            <id>Q8I100</id>
        </interactant>
        <interactant intactId="EBI-2655330">
            <id>P91857</id>
            <label>rab-5</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-2655296">
            <id>Q8I100</id>
        </interactant>
        <interactant intactId="EBI-328112">
            <id>Q9BI89</id>
            <label>sand-1</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAD56609.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379324.1">
        <property type="nucleotide sequence ID" value="NM_001392197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I100"/>
    <dbReference type="SMR" id="Q8I100"/>
    <dbReference type="IntAct" id="Q8I100">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="6239.Y39A1A.5.1"/>
    <dbReference type="PaxDb" id="6239-Y39A1A.5"/>
    <dbReference type="PeptideAtlas" id="Q8I100"/>
    <dbReference type="GeneID" id="176481"/>
    <dbReference type="UCSC" id="Y39A1A.5">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012644"/>
    <dbReference type="CTD" id="176481"/>
    <dbReference type="WormBase" id="Y39A1A.5a">
        <property type="protein sequence ID" value="CE44298"/>
        <property type="gene ID" value="WBGene00012644"/>
        <property type="gene designation" value="rabx-5"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018416_1_0_1"/>
    <dbReference type="OMA" id="QFVQNMN"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="PhylomeDB" id="Q8I100"/>
    <dbReference type="PRO" id="PR:Q8I100"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012644">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8I100">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF122">
        <property type="entry name" value="RABAPTIN-5-ASSOCIATED EXCHANGE FACTOR FOR RAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="6">
        <location>
            <begin position="220"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD56609.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y39A1A.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q8I100"/>
        </source>
    </evidence>
    <sequence length="517" mass="58029" checksum="B884B6A67CD06CED" modified="2010-01-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I102</accession>
    <name>Q8I102_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">bca-2</name>
        <name evidence="3" type="ORF">CELE_Y116A8C.28</name>
        <name evidence="5" type="ORF">Y116A8C.28</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAD56250.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001379318.1">
        <property type="nucleotide sequence ID" value="NM_001392454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I102"/>
    <dbReference type="PeptideAtlas" id="Q8I102"/>
    <dbReference type="GeneID" id="178484"/>
    <dbReference type="UCSC" id="Y116A8C.28b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013805"/>
    <dbReference type="CTD" id="178484"/>
    <dbReference type="WormBase" id="Y116A8C.28b">
        <property type="protein sequence ID" value="CE50670"/>
        <property type="gene ID" value="WBGene00013805"/>
        <property type="gene designation" value="bca-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2401634_0_0_1"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013805">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8I102">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF69">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD56250.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y116A8C.28b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q8I102"/>
        </source>
    </evidence>
    <sequence length="139" mass="16250" checksum="FFD47DE456C6DF7C" modified="2015-11-11" version="2">MPGLERILNGVIRFRQTVRKDLVKQFERIRDNPHPTAVFFTCMDSRMLPARFSAVIDPEDKLNVEDKLSQINTLQQLENVASHGFLKEFLVSQTVDLHAMWFDIYTGEMHMFSKPNKQFVLVDESNVEELIDEVEKHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I104</accession>
    <name>Q8I104_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_W09D6.1</name>
        <name evidence="3 5" type="ORF">W09D6.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAD54160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_871636.1">
        <property type="nucleotide sequence ID" value="NM_181907.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8I104"/>
    <dbReference type="SMR" id="Q8I104"/>
    <dbReference type="GeneID" id="176537"/>
    <dbReference type="UCSC" id="W09D6.1b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012356"/>
    <dbReference type="CTD" id="176537"/>
    <dbReference type="WormBase" id="W09D6.1b">
        <property type="protein sequence ID" value="CE31856"/>
        <property type="gene ID" value="WBGene00012356"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="PhylomeDB" id="Q8I104"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012356">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q8I104">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd17654">
        <property type="entry name" value="A_NRPS_acs4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048005">
        <property type="entry name" value="AASDH_AMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052091">
        <property type="entry name" value="Beta-ala_Activ/Resist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394:SF1">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrrolo-quinoline quinone repeat" evidence="2">
        <location>
            <begin position="533"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD54160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="W09D6.1b"/>
        </source>
    </evidence>
    <sequence length="714" mass="78546" checksum="95D67D4A2E59BD09" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-01-18" modified="2026-01-28" version="170" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I113-2</accession>
    <name>MNK_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform a of MAP kinase-interacting serine/threonine-protein kinase mnk-1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">MAP kinase integrating kinase-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnk-1</name>
        <name evidence="6" type="ORF">R166.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2007" name="Nature" volume="445" first="922" last="926">
            <title>eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Syntichaki P."/>
                <person name="Troulinaki K."/>
                <person name="Tavernarakis N."/>
            </authorList>
            <dbReference type="PubMed" id="17277769"/>
            <dbReference type="DOI" id="10.1038/nature05603"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2009" name="Genetics" volume="182" first="1035" last="1049">
            <title>Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1.</title>
            <authorList>
                <person name="Dorfman M."/>
                <person name="Gomes J.E."/>
                <person name="O'Rourke S."/>
                <person name="Bowerman B."/>
            </authorList>
            <dbReference type="PubMed" id="19528325"/>
            <dbReference type="DOI" id="10.1534/genetics.109.104885"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2015" name="Mol. Biol. Cell" volume="26" first="2096" last="2111">
            <title>Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.</title>
            <authorList>
                <person name="Matsunaga Y."/>
                <person name="Qadota H."/>
                <person name="Furukawa M."/>
                <person name="Choe H.H."/>
                <person name="Benian G.M."/>
            </authorList>
            <dbReference type="PubMed" id="25851606"/>
            <dbReference type="DOI" id="10.1091/mbc.E14-05-1009"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q8I113-2</id>
            <name evidence="5">a</name>
            <sequence type="described" ref="VSP_058707"/>
        </isoform>
        <isoform>
            <id>Q8I113-1</id>
            <name evidence="6">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="NP_496272.2">
        <property type="nucleotide sequence ID" value="NM_063871.6"/>
    </dbReference>
    <dbReference type="WormBase" id="R166.5a">
        <property type="protein sequence ID" value="CE40867"/>
        <property type="gene ID" value="WBGene00011304"/>
        <property type="gene designation" value="mnk-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9BUB5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="17277769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="R166.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="R166.5b"/>
        </source>
    </evidence>
    <sequence length="705" mass="78778" checksum="970600971546EEAE" modified="2007-05-15" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q8I7J4-2</accession>
    <name>COQ2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform e of 4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="1">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="1">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="1">PHB:PPT</shortName>
            <shortName evidence="1">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">coq-2</name>
        <name type="ORF">F57B9.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q8I7J4-2</id>
            <name>e</name>
            <sequence type="described" ref="VSP_017679 VSP_017680"/>
        </isoform>
        <isoform>
            <id>Q8I7J4-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="1"/>
    <dbReference type="RefSeq" id="NP_871684.1">
        <property type="nucleotide sequence ID" value="NM_181955.5"/>
    </dbReference>
    <dbReference type="WormBase" id="F57B9.4e">
        <property type="protein sequence ID" value="CE32446"/>
        <property type="gene ID" value="WBGene00000762"/>
        <property type="gene designation" value="coq-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <sequence length="370" mass="40477" checksum="822E452C42342C4E" modified="2006-03-21" version="2" precursor="true">MITRSIGIARRSNSINCIVGSNTSTSYSLDESTKRWISTSTKQPMSLIPTASSLVASSPPNLKPYLQLMRVDKPIGTWLLYWPCTWSIAMATPAGQLPSIYMLSLFGAGAFLMRSAGCVINDLWDKDFDKKVERTKLRPLACGSLTEKQAIGLLAGLLSSSLAILLQLNWYSVAVGASSMALVVGYPLAKRFTYWPQFVLGATLNWSVLIAWAELGHFNDFGIFLPLYTATILHTVIYDTIYSHQDKADDIMIGVKSTALRLGADTKKWLSAFGVGTVASLTACGIASDQTWPYYVALAATTAQLGWQVGTVDIDNGSDCWDKFKSNSWMGIILFSGIVASTLLKEDEKTKESRKNIGDENFDDVLVTTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-11-22" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q9GZE9-2</accession>
    <name>LDP1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform b of Lipid droplet localized protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ldp-1</name>
        <name evidence="3" type="ORF">F22F7.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2015" name="Biochim. Biophys. Acta" volume="1851" first="1337" last="1345">
            <title>Lipidomic and proteomic analysis of Caenorhabditis elegans lipid droplets and identification of ACS-4 as a lipid droplet-associated protein.</title>
            <authorList>
                <person name="Vrablik T.L."/>
                <person name="Petyuk V.A."/>
                <person name="Larson E.M."/>
                <person name="Smith R.D."/>
                <person name="Watts J.L."/>
            </authorList>
            <dbReference type="PubMed" id="26121959"/>
            <dbReference type="DOI" id="10.1016/j.bbalip.2015.06.004"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2015" name="Biochim. Biophys. Acta" volume="1853" first="2481" last="2491">
            <title>Identification of lipid droplet structure-like/resident proteins in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Na H."/>
                <person name="Zhang P."/>
                <person name="Chen Y."/>
                <person name="Zhu X."/>
                <person name="Liu Y."/>
                <person name="Liu Y."/>
                <person name="Xie K."/>
                <person name="Xu N."/>
                <person name="Yang F."/>
                <person name="Yu Y."/>
                <person name="Cichello S."/>
                <person name="Mak H.Y."/>
                <person name="Wang M.C."/>
                <person name="Zhang H."/>
                <person name="Liu P."/>
            </authorList>
            <dbReference type="PubMed" id="26025681"/>
            <dbReference type="DOI" id="10.1016/j.bbamcr.2015.05.020"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9GZE9-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_059216"/>
        </isoform>
        <isoform>
            <id>Q9GZE9-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_872194.2">
        <property type="nucleotide sequence ID" value="NM_182394.7"/>
    </dbReference>
    <dbReference type="WormBase" id="F22F7.1b">
        <property type="protein sequence ID" value="CE51032"/>
        <property type="gene ID" value="WBGene00017719"/>
        <property type="gene designation" value="ldp-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F22F7.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F22F7.1b"/>
        </source>
    </evidence>
    <sequence length="304" mass="34155" checksum="251432DE4CF6B03F" modified="2001-03-01" version="1">MQQKYSKQAKEQGVYVVSACGWDSIPADLGVNFLKKNFHGDLNHVESFVQLLTGPSGYSFNAGTYQTLILGLSGAATDKLGAVRKEIMPEKIVRGAVKLPKRPTLWEIKEKELNGVAVPFPGADKSIINRSQYYDATSRQVRPIHMETYIRLSSQFYGYLIGLWIMFLSIFVKYPFTRRILQQYPDQCSFYMFKNSGPSARQMAEASFVYWFFGYGYKETLPLDQQHEGKINRKVLATCKGPDAGYIATSGCVLSAALTLIRDKDNLPKDGGVYTTAAAFGNSKIYDYLASFGITYQLESEYDL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-11-25" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N4Y9-2</accession>
    <name>ZFPL1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Zinc finger protein-like 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">Y45G12B.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9N4Y9-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9N4Y9-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_035880"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="246" mass="27463" checksum="CBEF536A113A2050" modified="2000-10-01" version="1">MNTPEGRGDLLHWKCFDEWAANFPATTAPAGYRCPCCSQEVFPPINEVSPLIEKLREQLKQSNWARAALGLPTLPELNRPVPSPAPPQLKNAPVMHKEVPVHNNRSSTPATHLEMEDTASYSVSNNDVTFARKKNYGAESSSDTRPLLQLRDADNEENKYKRRPTMDWMRGLWRAKHGGSGVPQERASAKKIALFVIFLAVLALITIIMVMKRAGYSGEHSSDPLFDPMANPNIRVAVEDSRLPHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="175" xmlns="https://uniprot.org/uniprot">
    <accession>Q9TVL3-2</accession>
    <name>CDK9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Probable cyclin-dependent kinase 9</fullName>
            <ecNumber>2.7.11.22</ecNumber>
            <ecNumber>2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cell division protein kinase 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">cdk-9</name>
        <name type="ORF">H25P06.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Genes Dev." volume="16" first="2135" last="2146">
            <title>CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo.</title>
            <authorList>
                <person name="Shim E.Y."/>
                <person name="Walker A.K."/>
                <person name="Shi Y."/>
                <person name="Blackwell T.K."/>
            </authorList>
            <dbReference type="PubMed" id="12183367"/>
            <dbReference type="DOI" id="10.1101/gad.999002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9TVL3-1</id>
            <name>b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q9TVL3-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_016291 VSP_016292"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.7.11.22"/>
    <dbReference type="EC" id="2.7.11.23"/>
    <dbReference type="RefSeq" id="NP_492907.2">
        <property type="nucleotide sequence ID" value="NM_060506.5"/>
    </dbReference>
    <dbReference type="WormBase" id="H25P06.2a">
        <property type="protein sequence ID" value="CE37838"/>
        <property type="gene ID" value="WBGene00000410"/>
        <property type="gene designation" value="cdk-9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="445" mass="50130" checksum="2EB98637B821C984" modified="2005-03-01" version="2">MSAQNYHAGLHQSSTQRPPKRPNTEHAQEPPKRALIGGQTTPSSSGGGQTPNGTNYELEVKQQLSNYQKLFDQATYPFIRDVSTYEKLNKIGQGTFGEVFKARCKNTGRMVALKKILMENEKEGFPITALREVKMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLVMALCAHDLAGLLSNPKIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRPLYTNRVVTLWYRPPELLLGDRQYGTKIDVWGAGCIMAEMWTRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPLWSAMSSEPNSALPQGKYRILPNKMKNLMKFDAPDSKTDPFGKNVKQHDSATDDDALHLLEILLAIDPDKRPTSDEAEDDIWFFKDPVPMANVQDLMDTIPVRKFEAKWLKKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXI6</accession>
    <name>Q9XXI6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD kinase 2, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD kinase domain-containing protein 1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">nadk-2</name>
        <name evidence="7" type="ORF">CELE_Y17G7B.10</name>
        <name evidence="9" type="ORF">Y17G7B.10</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>NAD(+) + ATP = ADP + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="6"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAA19455.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T26501">
        <property type="entry name" value="T26501"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_496565.2">
        <property type="nucleotide sequence ID" value="NM_064164.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XXI6"/>
    <dbReference type="SMR" id="Q9XXI6"/>
    <dbReference type="GeneID" id="174846"/>
    <dbReference type="KEGG" id="cel:CELE_Y17G7B.10"/>
    <dbReference type="UCSC" id="Y17G7B.10a.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012463"/>
    <dbReference type="CTD" id="174846"/>
    <dbReference type="WormBase" id="Y17G7B.10a">
        <property type="protein sequence ID" value="CE37855"/>
        <property type="gene ID" value="WBGene00012463"/>
        <property type="gene designation" value="nadk-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039559_0_0_1"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012463">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XXI6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012355">
        <property type="entry name" value="NADK2_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158:SF5">
        <property type="entry name" value="NAD KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017565">
        <property type="entry name" value="Kin_ATP-NAD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA19455.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y17G7B.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XXI6"/>
        </source>
    </evidence>
    <sequence length="431" mass="48640" checksum="75A0CE3238D6C166" modified="2005-03-01" version="2">MRLPRSLAAALYQTQNTQSKRSIGNMEKPSFTPKKVLILSKLTRYEFEKRVNKGCSDEQLATLLKKRGSDYGRLLSKHKIHHSYLNTLQRELENAGIESRLVRRFGYTQEAVDWADAVFSAGGDGTFLMASSRVRTKHKPVIGINTDPQGSEGYMCLMRKLPEENLAGALKKLFSGNFEWLNRQRIRITVTGDDGISDAIELHDQQLNRDPATTRWTDNPRSPAREIEECMSLSPPVKKRMISEAVEIPEVEKETVELPVLALNEVFIGESLSSRVSYYEIGINDAQMLKQKSSGITICTGTGSTSWNFNINKLTEQCVQDLMKIVAEHCNLPQIPHGDKNAVSEICTKFNQQLIFDPDRKQLAFSVRDPIFNATFPPTDPRGFADKICIKSRGYDAHLVIDGGISYRFNDGSEAVMEVRDEDTLRTVVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="176" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXM9</accession>
    <name>Q9XXM9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">uig-1</name>
        <name evidence="6" type="ORF">CELE_F32F2.1</name>
        <name evidence="8" type="ORF">F32F2.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAA18349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T21663">
        <property type="entry name" value="T21663"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001366647.1">
        <property type="nucleotide sequence ID" value="NM_001380798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XXM9"/>
    <dbReference type="SMR" id="Q9XXM9"/>
    <dbReference type="GeneID" id="179808"/>
    <dbReference type="UCSC" id="F32F2.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00009337"/>
    <dbReference type="CTD" id="179808"/>
    <dbReference type="WormBase" id="F32F2.1a">
        <property type="protein sequence ID" value="CE18658"/>
        <property type="gene ID" value="WBGene00009337"/>
        <property type="gene designation" value="uig-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308213_0_0_1"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009337">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XXM9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DH_2"/>
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    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="223"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="435"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="578"/>
            <end position="619"/>
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        <location>
            <begin position="688"/>
            <end position="727"/>
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        <location>
            <begin position="886"/>
            <end position="906"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="889"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAA18349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="F32F2.1a"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="Q9XXM9"/>
        </source>
    </evidence>
    <sequence length="919" mass="104321" checksum="1F7223273A30A55A" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AJF0</accession>
    <name>A0A061AJF0_CAEEL</name>
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        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8 10" type="primary">best-22</name>
        <name evidence="8" type="ORF">CELE_ZC518.1</name>
        <name evidence="10" type="ORF">ZC518.1</name>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CDR32761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001307059.3"/>
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    <dbReference type="AGR" id="WB:WBGene00013921"/>
    <dbReference type="CTD" id="191197"/>
    <dbReference type="WormBase" id="ZC518.1e">
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        <property type="gene ID" value="WBGene00013921"/>
        <property type="gene designation" value="best-22"/>
    </dbReference>
    <dbReference type="OMA" id="ANSPDKC"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
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        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF20">
        <property type="entry name" value="BESTROPHIN HOMOLOG 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
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            <end position="441"/>
        </location>
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        </location>
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            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDR32761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="ZC518.1e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AJF0"/>
        </source>
    </evidence>
    <sequence length="510" mass="58659" checksum="E221288A8513F678" modified="2014-09-03" version="1">MTISYTLDVSQTNLQSFFSLLLRWRGSVWKAVFGQLAVWTAVFLLISCIYRYMLSPSQQDVFEQLIRYFDNKLDANIPLTFLLGFFVSFVVARWGSILNGIGWIDDASLLFATYIRGADEETRVIRRNLVRYLVLSQALVLRDISMQVRKRFPTMDTLAASGLMTHEEMDILDHIKDPYSRYWTSIQWSLNLVYECQKKGKVDSYYLMNKIVDEIGKFRHGLASLLKYDWVPVPLVYPQVIFLAVRIYFMICLIGRQFIVTGPNPSGIDLWLPITTMVQFLVYMGWMKVAEALLNPLGEDDDDLECNYIIDKNLITGLSIVDTMWKHDDTGYSMVEEHMAKTPAQKKDEFWGIDKIAPLYSMESAERSVHPLVGSASKINLVKNKKEIVMTPHKNKLSELDPSEQKTYLRRVNVSDHNAKHAKQRGLERANSPDKCLSKMRSRSKSELQYIQFYENGKFRTSANGSQNGVDLWTRAGDIEMNVATSNPNQVHPHSIAVFPPEEQQTTSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AJG8</accession>
    <name>A0A061AJG8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">dip-2</name>
        <name evidence="4" type="ORF">CELE_F28B3.4</name>
        <name evidence="6" type="ORF">F28B3.4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDR32766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293299.1">
        <property type="nucleotide sequence ID" value="NM_001306370.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A061AJG8"/>
    <dbReference type="GeneID" id="3565539"/>
    <dbReference type="AGR" id="WB:WBGene00017885"/>
    <dbReference type="CTD" id="3565539"/>
    <dbReference type="WormBase" id="F28B3.4c">
        <property type="protein sequence ID" value="CE49967"/>
        <property type="gene ID" value="WBGene00017885"/>
        <property type="gene designation" value="dip-2"/>
    </dbReference>
    <dbReference type="OMA" id="LVWTYWT"/>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017885">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AJG8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="292"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="945"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="1430"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR32766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F28B3.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AJG8"/>
        </source>
    </evidence>
    <sequence length="1541" mass="168415" checksum="DF4F1E31FDA128A6" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AJH3</accession>
    <name>A0A061AJH3_CAEEL</name>
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        <submittedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4 6" type="primary">dip-2</name>
        <name evidence="4" type="ORF">CELE_F28B3.4</name>
        <name evidence="6" type="ORF">F28B3.4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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    </dbReference>
    <dbReference type="RefSeq" id="NP_001293304.1">
        <property type="nucleotide sequence ID" value="NM_001306375.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A061AJH3"/>
    <dbReference type="GeneID" id="3565539"/>
    <dbReference type="AGR" id="WB:WBGene00017885"/>
    <dbReference type="CTD" id="3565539"/>
    <dbReference type="WormBase" id="F28B3.4i">
        <property type="protein sequence ID" value="CE49786"/>
        <property type="gene ID" value="WBGene00017885"/>
        <property type="gene designation" value="dip-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017885">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AJH3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="406"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="1544"/>
            <end position="1647"/>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDR32771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F28B3.4i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AJH3"/>
        </source>
    </evidence>
    <sequence length="1655" mass="179245" checksum="64F666A5AF452E3F" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AJH7</accession>
    <name>A0A061AJH7_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
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        <name evidence="1 3" type="primary">abtm-1</name>
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    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293306.1">
        <property type="nucleotide sequence ID" value="NM_001306377.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AJH7"/>
    <dbReference type="SMR" id="A0A061AJH7"/>
    <dbReference type="PeptideAtlas" id="A0A061AJH7"/>
    <dbReference type="GeneID" id="171807"/>
    <dbReference type="AGR" id="WB:WBGene00022281"/>
    <dbReference type="CTD" id="171807"/>
    <dbReference type="WormBase" id="Y74C10AR.3b">
        <property type="protein sequence ID" value="CE49984"/>
        <property type="gene ID" value="WBGene00022281"/>
        <property type="gene designation" value="abtm-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2388198_0_0_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022281">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HAlF transporter (PGP related)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR32776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y74C10AR.3b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AJH7"/>
        </source>
    </evidence>
    <sequence length="94" mass="10377" checksum="A9D56FF64BD0C925" modified="2014-09-03" version="1">MKALKGAVEKRTSLFIAHRLATIVDADIIYVLQDGKVAEKGSHFDLLAVDGLYAQLWKSQNIHGVAPKKSKEEDDDLMLELDLDKCCGSSSCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKK5</accession>
    <name>A0A061AKK5_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C48D1.5</name>
        <name evidence="2" type="ORF">CELE_C48D1.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293874.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AKK5"/>
    <dbReference type="GeneID" id="3564995"/>
    <dbReference type="AGR" id="WB:WBGene00008178"/>
    <dbReference type="CTD" id="3564995"/>
    <dbReference type="WormBase" id="C48D1.5f">
        <property type="protein sequence ID" value="CE49951"/>
        <property type="gene ID" value="WBGene00008178"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1070529_0_0_1"/>
    <dbReference type="OrthoDB" id="5870039at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008178">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AKK5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR32629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C48D1.5f"/>
        </source>
    </evidence>
    <sequence length="216" mass="24666" checksum="3C6F3C390B5DD9C5" modified="2014-09-03" version="1">MRAGHVYDPLIDHLLEDGCRYPVRQTFLEREFIEVVYGNVTGYVSGRIQTIVEDGFLDWDNFKQRHLEIPYEFPEVNGYIFVEDLSPICSKNGILFLRICFSKNPTRKFGTPDVGIFGRCKAKSTAMIFLNGNILKISSSSSPIILYSSWTLFGVIGFIIISFFLILLVVLSCIRIRKNTGIHKNRENVPNLIPDKLSLSHPNIPFIDEDSIIFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKL1</accession>
    <name>A0A061AKL1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Fibulin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">fbl-1</name>
        <name evidence="16" type="ORF">CELE_F56H11.1</name>
        <name evidence="18" type="ORF">F56H11.1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Homomultimerizes and interacts with various extracellular matrix components.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
            <location evidence="1 12">Extracellular space</location>
            <location evidence="1 12">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="CDR32634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001306950.3"/>
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        <property type="protein sequence ID" value="CE49885"/>
        <property type="gene ID" value="WBGene00001403"/>
        <property type="gene designation" value="fbl-1"/>
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    <dbReference type="Proteomes" id="UP000001940">
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        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
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        <property type="entry name" value="Nephronectin_domain"/>
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        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
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        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
        <property type="entry name" value="UROMODULIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cEGF"/>
        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="match status" value="6"/>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
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    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 12" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001598667" description="Fibulin-1" evidence="14">
        <location>
            <begin position="18"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="390"/>
            <end position="430"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDR32634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="F56H11.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="A0A061AKL1"/>
        </source>
    </evidence>
    <sequence length="667" mass="72525" checksum="53426A0737048F3D" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKL8</accession>
    <name>A0A061AKL8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C28D4.10</name>
        <name evidence="1" type="ORF">CELE_C28D4.10</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293884.1">
        <property type="nucleotide sequence ID" value="NM_001306955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AKL8"/>
    <dbReference type="GeneID" id="3565422"/>
    <dbReference type="AGR" id="WB:WBGene00007796"/>
    <dbReference type="CTD" id="3565422"/>
    <dbReference type="WormBase" id="C28D4.10b">
        <property type="protein sequence ID" value="CE49915"/>
        <property type="gene ID" value="WBGene00007796"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2006017_0_0_1"/>
    <dbReference type="OrthoDB" id="5808566at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007796">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDR32639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C28D4.10b"/>
        </source>
    </evidence>
    <sequence length="69" mass="7977" checksum="03CDDED38E8B2AAE" modified="2014-09-03" version="1">MLVKEIDVSGHILRLYFEGQELWIPDRTLASYRVRPGDTVDIYLENIAEQLAIKFGNQDKSPDGKLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AKN1</accession>
    <name>A0A061AKN1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CELE_Y62E10A.13</name>
        <name evidence="14 16" type="ORF">Y62E10A.13</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293892.1">
        <property type="nucleotide sequence ID" value="NM_001306963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AKN1"/>
    <dbReference type="SMR" id="A0A061AKN1"/>
    <dbReference type="GeneID" id="178304"/>
    <dbReference type="AGR" id="WB:WBGene00013379"/>
    <dbReference type="CTD" id="178304"/>
    <dbReference type="WormBase" id="Y62E10A.13e">
        <property type="protein sequence ID" value="CE49767"/>
        <property type="gene ID" value="WBGene00013379"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013379">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AKN1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.210:FF:000003">
        <property type="entry name" value="Phosphoserine phosphatase SerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000077">
        <property type="entry name" value="Phosphoserine phosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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        <location>
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        </location>
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            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CTQ86434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="C04A2.3f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AQW8"/>
        </source>
    </evidence>
    <sequence length="1126" mass="128031" checksum="04B01F06D7762D41" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AQY8</accession>
    <name>A0A0K3AQY8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="ORF">C24H12.4</name>
        <name evidence="10" type="ORF">CELE_C24H12.4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001427163.1">
        <property type="nucleotide sequence ID" value="NM_001440235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AQY8"/>
    <dbReference type="SMR" id="A0A0K3AQY8"/>
    <dbReference type="GeneID" id="173432"/>
    <dbReference type="AGR" id="WB:WBGene00016073"/>
    <dbReference type="CTD" id="173432"/>
    <dbReference type="WormBase" id="C24H12.4c">
        <property type="protein sequence ID" value="CE51004"/>
        <property type="gene ID" value="WBGene00016073"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016073">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AQY8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CTQ86454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C24H12.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AQY8"/>
        </source>
    </evidence>
    <sequence length="362" mass="41161" checksum="B52B58786318FB97" modified="2015-11-11" version="1">MTSATLKDDMTTLKKLFMTGPVITIKLTEGDLPNSDQLTQYQLTCGSDEERFAILVAMFKLKLIVGRSILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIVIASDVSDADGSKLKEEIAGKSDEKPEKDEKKGKKASKLDKESGVSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARGFNKGTALSFCIPSERAHLEQIQEEINQQMGRKVLQPYEFRIKELDTFLLRTREALSKCTKGVIKKARLKEIRQELMRSANLQTFFAKNEREKLLMQTDCHPVMLKINSPAIADVTSYMVPEALRGMDFSAPGAKNRRYNMGQKHRQKLKHKFQKKGKDPLKTFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AQZ1</accession>
    <name>A0A0K3AQZ1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DiSHevelled related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">dsh-1</name>
        <name evidence="13" type="ORF">C34F11.9</name>
        <name evidence="11" type="ORF">CELE_C34F11.9</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSH family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300520.1">
        <property type="nucleotide sequence ID" value="NM_001313591.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AQZ1"/>
    <dbReference type="SMR" id="A0A0K3AQZ1"/>
    <dbReference type="GeneID" id="173894"/>
    <dbReference type="KEGG" id="cel:CELE_C34F11.9"/>
    <dbReference type="AGR" id="WB:WBGene00001101"/>
    <dbReference type="CTD" id="173894"/>
    <dbReference type="WormBase" id="C34F11.9d">
        <property type="protein sequence ID" value="CE50407"/>
        <property type="gene ID" value="WBGene00001101"/>
        <property type="gene designation" value="dsh-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031689at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001101">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AQZ1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048730">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06717">
        <property type="entry name" value="PDZ_Dishevelled-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000400">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000203">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008339">
        <property type="entry name" value="Dishevelled_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003351">
        <property type="entry name" value="Dishevelled_protein_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF25">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02377">
        <property type="entry name" value="Dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01760">
        <property type="entry name" value="DISHEVELLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="107"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="10">
        <location>
            <begin position="294"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="435"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CTQ86459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="C34F11.9d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AQZ1"/>
        </source>
    </evidence>
    <sequence length="506" mass="55246" checksum="BC3616F93C1500EE" modified="2015-11-11" version="1">MSTDSESMISAAIPGYLKSAAYNRRFPQHYLGHRRHLEESTIGSESDARVFSDDDDRGSTTTDFTSVSRQHEKMAKKKKNKRNFRKPSRASSFSSITESSMSLDVITVNLNMDTVNFLGISIVGQTSNCGDNGIYVANIMKGGAVALDGRIEAGDMILQVNETSFENFTNDQAVDVLREAVSRRGPIKLTVAKSFENGQSCFTIPRNSREEPVRPIDTQAWIQHTNAMRGMPSIVEESAPTPIPGEWPHGRPPSSSTVTSNGSNGQNTVVGGGAHIILDIHTDKKKVVEIMAMPGSGLDIKNRTWLKIPIPMSFLGSDLVEWLLDHVEGLRERKTARNFAADLLKLKYIAHVVNKVTFTEQCYYVLGDECSDYARFRNEDGGPKYQWTIGMNGMSAGNGSSVMLPPPHLPGGMAGPPGAFKGMAPSMVSGYASMPASPFPPAQLQQQRREGSTTSGSSGGGIRKQRVVVLPRKPSSSANVPFDDSSTIYEESNNSFLMATGQRYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AQZ6</accession>
    <name>A0A0K3AQZ6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CPG4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C50D2.6</name>
        <name evidence="1" type="ORF">CELE_C50D2.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300525.1">
        <property type="nucleotide sequence ID" value="NM_001313596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AQZ6"/>
    <dbReference type="GeneID" id="3565416"/>
    <dbReference type="AGR" id="WB:WBGene00016809"/>
    <dbReference type="CTD" id="3565416"/>
    <dbReference type="WormBase" id="C50D2.6c">
        <property type="protein sequence ID" value="CE50571"/>
        <property type="gene ID" value="WBGene00016809"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5845707at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016809">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AQZ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944:SF4">
        <property type="entry name" value="CPG4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944">
        <property type="entry name" value="PROTEIN CBG02791-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CTQ86464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C50D2.6c"/>
        </source>
    </evidence>
    <sequence length="107" mass="11909" checksum="BF40252D7D91AF62" modified="2015-11-11" version="1">MLCKKLGSMIECVEPVTRAGCGDQAAKMMLRFITVGFSSFEQLYSQLGISDQLPAACKSLLSLQKRTVLPERRHYVLPQASSEYSVFSSTSSTPHIPIILFSYLILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR82</accession>
    <name>A0A0K3AR82_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase FkbM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">BE0003N10.6</name>
        <name evidence="2" type="ORF">CELE_BE0003N10.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299860.1">
        <property type="nucleotide sequence ID" value="NM_001312931.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR82"/>
    <dbReference type="GeneID" id="25502968"/>
    <dbReference type="AGR" id="WB:WBGene00255598"/>
    <dbReference type="CTD" id="25502968"/>
    <dbReference type="WormBase" id="BE0003N10.6b">
        <property type="protein sequence ID" value="CE50136"/>
        <property type="gene ID" value="WBGene00255598"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863008at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00255598">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR82">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989:SF6">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989">
        <property type="entry name" value="UNCHARACTERIZED DUF13 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="37"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="BE0003N10.6b"/>
        </source>
    </evidence>
    <sequence length="254" mass="29801" checksum="7F6B5B7A9837B694" modified="2015-11-11" version="1">MESVKKQFSECITPIVNQWKGRAKEMNLEWVSKASICDKLPIFEDLKVIPFNNQHETKWAVMPKCKEENILVTLGVGHDTTAEERLNRTIPNTKFYGADPIIEPNRQMYSAFGKFFPFAIGKEPGFTKFRVLPNQSQKTRKYVYQDVTTIPFVYFLHDILKLQKIDFAWIDIEGGEFEFLEKIHNDVQFCQFNIEVHSRFAPAGAQVFHDFIFRVLEEQKYVFLQSMHTGGGVHRMFFLNVQDKECLAKYFNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR87</accession>
    <name>A0A0K3AR87_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ELMO domain-containing protein C56G7.3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">elmd-1</name>
        <name evidence="3" type="ORF">C56G7.3</name>
        <name evidence="1" type="ORF">CELE_C56G7.3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299865.1">
        <property type="nucleotide sequence ID" value="NM_001312936.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR87"/>
    <dbReference type="SMR" id="A0A0K3AR87"/>
    <dbReference type="GeneID" id="175439"/>
    <dbReference type="AGR" id="WB:WBGene00008348"/>
    <dbReference type="CTD" id="175439"/>
    <dbReference type="WormBase" id="C56G7.3c">
        <property type="protein sequence ID" value="CE50345"/>
        <property type="gene ID" value="WBGene00008348"/>
        <property type="gene designation" value="elmd-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266227at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR87">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CTQ86565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C56G7.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AR87"/>
        </source>
    </evidence>
    <sequence length="52" mass="5979" checksum="51041DB0CD8A6672" modified="2015-11-11" version="1">MCRFCSIYKSQKCTLANTQTIFSEITRQLEKSPLSLIMLLNPTNDELINTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AR90</accession>
    <name>A0A0K3AR90_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lethal giant larvae homologue 2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tom-1</name>
        <name evidence="7" type="ORF">CELE_M01A10.2</name>
        <name evidence="9" type="ORF">M01A10.2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CTQ86367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300428.1">
        <property type="nucleotide sequence ID" value="NM_001313499.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AR90"/>
    <dbReference type="SMR" id="A0A0K3AR90"/>
    <dbReference type="PaxDb" id="6239-M01A10.2c"/>
    <dbReference type="GeneID" id="172209"/>
    <dbReference type="AGR" id="WB:WBGene00006594"/>
    <dbReference type="CTD" id="172209"/>
    <dbReference type="WormBase" id="M01A10.2h">
        <property type="protein sequence ID" value="CE50232"/>
        <property type="gene ID" value="WBGene00006594"/>
        <property type="gene designation" value="tom-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006594">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AR90">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098981">
        <property type="term" value="C:cholinergic synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="SynGO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098674">
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</entry>
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            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CTQ86573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F48E8.8c"/>
        </source>
    </evidence>
    <sequence length="27" mass="3343" checksum="C4FC851F3F4A8F75" modified="2015-11-11" version="1">MIANEEQIVQHRPNNFKFNRMIQDIQK</sequence>
</entry>
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    <accession>A0A0K3ARU7</accession>
    <name>A0A0K3ARU7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">str-134</name>
        <name evidence="4" type="ORF">C05E4.6</name>
        <name evidence="2" type="ORF">CELE_C05E4.6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
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    </dbReference>
    <dbReference type="RefSeq" id="NP_001300052.1">
        <property type="nucleotide sequence ID" value="NM_001313123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARU7"/>
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    <dbReference type="KEGG" id="cel:CELE_C05E4.6"/>
    <dbReference type="AGR" id="WB:WBGene00006182"/>
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        <property type="protein sequence ID" value="CE50866"/>
        <property type="gene ID" value="WBGene00006182"/>
        <property type="gene designation" value="str-134"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10373245at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
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        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
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    </dbReference>
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        <property type="entry name" value="SEVEN TM RECEPTOR"/>
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    </dbReference>
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        <property type="entry name" value="7TM_GPCR_Str"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="24"/>
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        <location>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="153" mass="16856" checksum="6A6ED20E5183366D" modified="2015-11-11" version="1">MFAAGQYWIFGANGEKIWCLRDCFATLGLVGLMGICCFVIIFCGLKTFRKMIEVQGSMSKQTAALNKQLFLTLTLQTLLPFILMYGPVGLIFFAPLFEWNLQLFVSSAGATTAIYPAFEPLIVIFCISLFRNAVFPCTRSKVTTSSGAFSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARU9</accession>
    <name>A0A0K3ARU9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_R01H2.4</name>
        <name evidence="2 4" type="ORF">R01H2.4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299878.1">
        <property type="nucleotide sequence ID" value="NM_001312949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARU9"/>
    <dbReference type="GeneID" id="187511"/>
    <dbReference type="AGR" id="WB:WBGene00019812"/>
    <dbReference type="CTD" id="187511"/>
    <dbReference type="WormBase" id="R01H2.4b">
        <property type="protein sequence ID" value="CE50656"/>
        <property type="gene ID" value="WBGene00019812"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5787578at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019812">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARU9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R01H2.4b"/>
        </source>
    </evidence>
    <sequence length="388" mass="44241" checksum="AED71C6E2EB7D828" modified="2015-11-11" version="1">MFNAGGLVPRILFGGAPLRNSLTNLTEFAKSQKVLSMWSRDLSHLDRMKQQKIVDELSSKAQSSGNCRKQKKDEACQTGNNKASASLIPVLSSPVPKHGINYKDPNEDEKKAPILVWINHAVVEMPDEYFDGEHVYTWNHLEYVRVHGSVAEPIKIHRGKFEFNTVMVPAQNRQLLMLVFYGYKSGLCSLEVMRKFVSNYYDSSCPCIVRKANDNNTSPKMSIYLPHWKTKDFPSSRISQHLVATMNLNSLFVAGGFGDLAVEDAVPSATGDPKKVSHLQHFGLLSFRNSPKKTYLRTPEEKTLLGKKSRQSRNKKQKRTNKPVKIPMNEKNANQVELVQYPICVVLWDRQHEIPVYMGKVTGEKTEQEIEEMKLKETEKRQKNWVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARV6</accession>
    <name>A0A0K3ARV6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_R151.1</name>
        <name evidence="2 4" type="ORF">R151.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299883.1">
        <property type="nucleotide sequence ID" value="NM_001312954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARV6"/>
    <dbReference type="SMR" id="A0A0K3ARV6"/>
    <dbReference type="GeneID" id="187907"/>
    <dbReference type="AGR" id="WB:WBGene00020106"/>
    <dbReference type="CTD" id="187907"/>
    <dbReference type="WormBase" id="R151.1d">
        <property type="protein sequence ID" value="CE50488"/>
        <property type="gene ID" value="WBGene00020106"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020106">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARV6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000677">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF594">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="R151.1d"/>
        </source>
    </evidence>
    <sequence length="215" mass="24169" checksum="9E636867DDA3BC61" modified="2015-11-11" version="1">MYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEKDSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSRPGVYIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKIEQIANVDADAPPSDPPAKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARW0</accession>
    <name>A0A0K3ARW0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class BC (Class B-like)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srbc-20</name>
        <name evidence="4" type="ORF">C45H4.11</name>
        <name evidence="2" type="ORF">CELE_C45H4.11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300062.1">
        <property type="nucleotide sequence ID" value="NM_001313133.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARW0"/>
    <dbReference type="SMR" id="A0A0K3ARW0"/>
    <dbReference type="GeneID" id="183492"/>
    <dbReference type="KEGG" id="cel:CELE_C45H4.11"/>
    <dbReference type="AGR" id="WB:WBGene00016693"/>
    <dbReference type="CTD" id="183492"/>
    <dbReference type="WormBase" id="C45H4.11b">
        <property type="protein sequence ID" value="CE50909"/>
        <property type="gene ID" value="WBGene00016693"/>
        <property type="gene designation" value="srbc-20"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868788at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016693">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARW0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019420">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srbc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10664:SF2">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS BC (CLASS B-LIKE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10664">
        <property type="entry name" value="SERPENTINE RECEPTOR-C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10316">
        <property type="entry name" value="7TM_GPCR_Srbc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C45H4.11b"/>
        </source>
    </evidence>
    <sequence length="258" mass="29753" checksum="96965F017471AA75" modified="2015-11-11" version="1">MTLFYFRFLLDVILSVLVAAFLTSDIIYFTFSEKMDSQLIVVIFYIPLLASNVAAVRSIVILFISVERVVASYFPIFFHNHRKFRFKVFIMILAVFYGLTEDIVLYVFCDFQLKLVPNCVAFGCTINACYHQYWITHRMTVFALMFLFSIFLASKLFMLRKSKNVGKNEQFRMNRLALIDIGNVTLFEFFPIFLANQLSKYFNFKSLGPYGISIKMLGCAVEAVLMLYILKGKKRRGSERSNSKIASGKTNCILVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARW1</accession>
    <name>A0A0K3ARW1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hpc2-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">pqn-80</name>
        <name evidence="3" type="ORF">CELE_Y111B2A.14</name>
        <name evidence="5" type="ORF">Y111B2A.14</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299888.1">
        <property type="nucleotide sequence ID" value="NM_001312959.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0K3ARW1"/>
    <dbReference type="GeneID" id="176683"/>
    <dbReference type="AGR" id="WB:WBGene00004161"/>
    <dbReference type="CTD" id="176683"/>
    <dbReference type="WormBase" id="Y111B2A.14d">
        <property type="protein sequence ID" value="CE50491"/>
        <property type="gene ID" value="WBGene00004161"/>
        <property type="gene designation" value="pqn-80"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68076at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004161">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARW1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053109">
        <property type="entry name" value="Ser/Thr-Kinase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31534">
        <property type="entry name" value="ATAXIN 7, ISOFORM A"/>
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</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS61</accession>
    <name>A0A0K3AS61_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2428 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_H24K24.2</name>
        <name evidence="1 3" type="ORF">H24K24.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300127.1">
        <property type="nucleotide sequence ID" value="NM_001313198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS61"/>
    <dbReference type="GeneID" id="186774"/>
    <dbReference type="AGR" id="WB:WBGene00019239"/>
    <dbReference type="CTD" id="186774"/>
    <dbReference type="WormBase" id="H24K24.2d">
        <property type="protein sequence ID" value="CE50696"/>
        <property type="gene ID" value="WBGene00019239"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5909998at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019239">
        <property type="expression patterns" value="Expressed in embryo and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS61">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CTQ86826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="H24K24.2d"/>
        </source>
    </evidence>
    <sequence length="196" mass="22689" checksum="81CE4522609700CB" modified="2015-11-11" version="1">MYRKISCDLKNFSKCGTRIFYCTSIESLFRSLIDFTNLKNELATCRCLEELHRQLNASRSTENLHYSSLLKLVIQTMNMFTSRSTLINGLQCLIWIINHKMDQIGPVNMFFTLKKLLSLADLLPETYSNAEIIRSNRLYWDAIVKLTNSENTNFDEICWTAMNMMSKVTYAAGSGMRSKAGIQNERTLFSQFLPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS63</accession>
    <name>A0A0K3AS63_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fmo-5</name>
        <name evidence="6" type="ORF">CELE_H24K24.5</name>
        <name evidence="8" type="ORF">H24K24.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300132.1">
        <property type="nucleotide sequence ID" value="NM_001313203.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS63"/>
    <dbReference type="SMR" id="A0A0K3AS63"/>
    <dbReference type="GeneID" id="178596"/>
    <dbReference type="KEGG" id="cel:CELE_H24K24.5"/>
    <dbReference type="AGR" id="WB:WBGene00001480"/>
    <dbReference type="CTD" id="178596"/>
    <dbReference type="WormBase" id="H24K24.5b">
        <property type="protein sequence ID" value="CE50750"/>
        <property type="gene ID" value="WBGene00001480"/>
        <property type="gene designation" value="fmo-5"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001480">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS63">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000608">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CTQ86831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="H24K24.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AS63"/>
        </source>
    </evidence>
    <sequence length="180" mass="20627" checksum="8CA4D71BEC0697FB" modified="2015-11-11" version="1">MIEGGKLIEVDENKSDIYKYVFPLATADHNTLAVIGLIQPLGSIMPISEMQARVYMESFANGMKLPSKDQMLTDIAEKREIMSARYVASRRHTIQVDYASYMHELGEIIGCNPDMRSLWMWKPLTAWKVYFGPCVPYVFRLNGPNKWEGAEAAIWDVDYRSERATNSKIARKSLEGKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS68</accession>
    <name>A0A0K3AS68_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">dre-1</name>
        <name evidence="13" type="ORF">CELE_K04A8.6</name>
        <name evidence="15" type="ORF">K04A8.6</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368566.1">
        <property type="nucleotide sequence ID" value="NM_001380672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS68"/>
    <dbReference type="SMR" id="A0A0K3AS68"/>
    <dbReference type="GeneID" id="179045"/>
    <dbReference type="KEGG" id="cel:CELE_K04A8.6"/>
    <dbReference type="AGR" id="WB:WBGene00001089"/>
    <dbReference type="CTD" id="179045"/>
    <dbReference type="WormBase" id="K04A8.6b">
        <property type="protein sequence ID" value="CE50130"/>
        <property type="gene ID" value="WBGene00001089"/>
        <property type="gene designation" value="dre-1"/>
    </dbReference>
    <dbReference type="OMA" id="KESFHQL"/>
    <dbReference type="OrthoDB" id="427974at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001089">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS68">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19676">
        <property type="entry name" value="UBR-box_UBR6_FBXO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000005">
        <property type="entry name" value="F-box only protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000006">
        <property type="entry name" value="F-box only protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000100">
        <property type="entry name" value="F-box protein dre-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047504">
        <property type="entry name" value="FBXO11_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF20">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="245"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="929"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="929"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CTQ86836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="K04A8.6b"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114359" checksum="D7E84D3378774BDA" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS71</accession>
    <name>A0A0K3AS71_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2 11">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">egl-8</name>
        <name evidence="17" type="ORF">B0348.4</name>
        <name evidence="15" type="ORF">CELE_B0348.4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2 11"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368552.1">
        <property type="nucleotide sequence ID" value="NM_001380576.2"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0K3AS71"/>
    <dbReference type="GeneID" id="178537"/>
    <dbReference type="AGR" id="WB:WBGene00001177"/>
    <dbReference type="CTD" id="178537"/>
    <dbReference type="WormBase" id="B0348.4e">
        <property type="protein sequence ID" value="CE50648"/>
        <property type="gene ID" value="WBGene00001177"/>
        <property type="gene designation" value="egl-8"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001177">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS71">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16200">
        <property type="entry name" value="EFh_PI-PLCbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1230.10:FF:000006">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000047">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000093">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_dom"/>
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    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="14">
        <location>
            <begin position="839"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="958"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="510"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="632"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="727"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1153"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1232"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="572"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="733"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1155"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1232"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1249"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1273"/>
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        </location>
    </feature>
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        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="387"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CTQ86714.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="B0348.4e"/>
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    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AS71"/>
        </source>
    </evidence>
    <sequence length="1500" mass="168218" checksum="F89C93924087D23E" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS73</accession>
    <name>A0A0K3AS73_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 23" type="primary">mrck-1</name>
        <name evidence="21" type="ORF">CELE_K08B12.5</name>
        <name evidence="23" type="ORF">K08B12.5</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300142.1">
        <property type="nucleotide sequence ID" value="NM_001313213.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0K3AS73"/>
    <dbReference type="GeneID" id="179013"/>
    <dbReference type="AGR" id="WB:WBGene00006437"/>
    <dbReference type="CTD" id="179013"/>
    <dbReference type="WormBase" id="K08B12.5c">
        <property type="protein sequence ID" value="CE50453"/>
        <property type="gene ID" value="WBGene00006437"/>
        <property type="gene designation" value="mrck-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2156623at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006437">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS73">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20809">
        <property type="entry name" value="C1_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01243">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF66">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GENGHIS KHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 21" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="20">
        <location>
            <begin position="72"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
        <location>
            <begin position="675"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="744"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="19">
        <location>
            <begin position="899"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="1262"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="172"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="532"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CTQ86841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WormBase" id="K08B12.5c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AS73"/>
        </source>
    </evidence>
    <sequence length="1310" mass="148582" checksum="6EC1F85A760F9CEE" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS74</accession>
    <name>A0A0K3AS74_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">egl-8</name>
        <name evidence="15" type="ORF">B0348.4</name>
        <name evidence="13" type="ORF">CELE_B0348.4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="6"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300020.1">
        <property type="nucleotide sequence ID" value="NM_001313091.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0K3AS74"/>
    <dbReference type="GeneID" id="178537"/>
    <dbReference type="AGR" id="WB:WBGene00001177"/>
    <dbReference type="CTD" id="178537"/>
    <dbReference type="WormBase" id="B0348.4j">
        <property type="protein sequence ID" value="CE50563"/>
        <property type="gene ID" value="WBGene00001177"/>
        <property type="gene designation" value="egl-8"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001177">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS74">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16200">
        <property type="entry name" value="EFh_PI-PLCbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
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    </dbReference>
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        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.20.1230.10:FF:000006">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
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        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.20.20.190:FF:000052">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.20.20.190:FF:000047">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
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    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
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    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
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    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="12">
        <location>
            <begin position="673"/>
            <end position="789"/>
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    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="792"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="510"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="561"/>
            <end position="622"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="987"/>
            <end position="1034"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1091"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1103"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="989"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1119"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="355"/>
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    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="385"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="387"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CTQ86719.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="B0348.4j"/>
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    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AS74"/>
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    </evidence>
    <sequence length="1346" mass="152896" checksum="773F2B80C0832269" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS80</accession>
    <name>A0A0K3AS80_CAEEL</name>
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        <recommendedName>
            <fullName evidence="2 11">Phosphoinositide phospholipase C</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="15 17" type="primary">egl-8</name>
        <name evidence="17" type="ORF">B0348.4</name>
        <name evidence="15" type="ORF">CELE_B0348.4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2 11"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001380580.2"/>
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        <property type="gene ID" value="WBGene00001177"/>
        <property type="gene designation" value="egl-8"/>
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        <property type="component" value="Chromosome V"/>
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    <dbReference type="Bgee" id="WBGene00001177">
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        <property type="expression patterns" value="baseline and differential"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
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    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PI-PLC_fam"/>
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    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
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        <property type="entry name" value="PLC-beta_C"/>
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    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
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    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
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    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
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    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
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    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
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        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PLC-beta_C"/>
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        <property type="entry name" value="C-terminal domain of PLC-beta"/>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
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        <location>
            <begin position="811"/>
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        <location>
            <begin position="930"/>
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            <begin position="482"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="1204"/>
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            <begin position="515"/>
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            <begin position="705"/>
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            <begin position="1127"/>
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        <ligand>
            <name>Ca(2+)</name>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <sequence length="1472" mass="164787" checksum="266A0F8715A9F077" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS90</accession>
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            <fullName evidence="8">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
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    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
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        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
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            <name>Ca(2+)</name>
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        </cofactor>
        <text evidence="10">Binds 1 Ca(2+) ion per subunit.</text>
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        <ligand>
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            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="1225" mass="139333" checksum="DF3BB8CFB1A8DC4F" modified="2015-11-11" version="1"> </sequence>
</entry>
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            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
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</entry>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C05E4.13b"/>
        </source>
    </evidence>
    <sequence length="269" mass="30419" checksum="59E1CC72C16A6AA4" modified="2015-11-11" version="1">MSCLMDLLFVGFFGTSMSILALHFIYRFFSVTNSRYLKIFDSWLIIPIFTVPLINGVLYMITGGIILSADAETDRFMRENYLKVIKNQTNLEDLYYMGPFFWPKLENSITETYFSWKGAEGSLIVMGSIGLSSSIMIFFGIKGYISMNNLLAITSNSEQFQNIQKQLFQALCIQTIIPVVLMHIPASAIYITIFFEKSSVIVGETLSLTIAMYPAMNPLPTIYIVQSYRKAVKDYFISIKNTLLKKPTVIPVSHTVQVIPVSSIFTTTS</sequence>
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        <submittedName>
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    </gene>
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            <taxon>Rhabditomorpha</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001330879.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A168H5A5"/>
    <dbReference type="SMR" id="A0A168H5A5"/>
    <dbReference type="GeneID" id="179321"/>
    <dbReference type="AGR" id="WB:WBGene00002036"/>
    <dbReference type="CTD" id="179321"/>
    <dbReference type="WormBase" id="F36D4.3i">
        <property type="protein sequence ID" value="CE51553"/>
        <property type="gene ID" value="WBGene00002036"/>
        <property type="gene designation" value="hum-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002036">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
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    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VVC12395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T23E7.2i"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="A0A5E4LX00"/>
        </source>
    </evidence>
    <sequence length="868" mass="95449" checksum="A8F35B40E9F4835A" modified="2019-11-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-11-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5E4LX31</accession>
    <name>A0A5E4LX31_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nhr-48</name>
        <name evidence="13" type="ORF">CELE_ZK662.3</name>
        <name evidence="15" type="ORF">ZK662.3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="VVC12415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001362160.1">
        <property type="nucleotide sequence ID" value="NM_001375187.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5E4LX31"/>
    <dbReference type="SMR" id="A0A5E4LX31"/>
    <dbReference type="GeneID" id="181661"/>
    <dbReference type="AGR" id="WB:WBGene00003638"/>
    <dbReference type="CTD" id="181661"/>
    <dbReference type="WormBase" id="ZK662.3d">
        <property type="protein sequence ID" value="CE53571"/>
        <property type="gene ID" value="WBGene00003638"/>
        <property type="gene designation" value="nhr-48"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6355676at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A5E4LX31">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06966">
        <property type="entry name" value="NR_DBD_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000042">
        <property type="entry name" value="Nuclear hormone receptor HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF508">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="107"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VVC12415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="ZK662.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="A0A5E4LX31"/>
        </source>
    </evidence>
    <sequence length="822" mass="91331" checksum="A840E2A2C1A7A2FA" modified="2019-11-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5S9MQ08</accession>
    <name>A0A5S9MQ08_CAEEL</name>
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        <submittedName>
            <fullName evidence="15">DDT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">nurf-1</name>
        <name evidence="15" type="ORF">CELE_F26H11.2</name>
        <name evidence="17" type="ORF">F26H11.2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAA0059157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001364539.1">
        <property type="nucleotide sequence ID" value="NM_001377899.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A5S9MQ08"/>
    <dbReference type="GeneID" id="175098"/>
    <dbReference type="AGR" id="WB:WBGene00009180"/>
    <dbReference type="CTD" id="175098"/>
    <dbReference type="WormBase" id="F26H11.2s">
        <property type="protein sequence ID" value="CE53890"/>
        <property type="gene ID" value="WBGene00009180"/>
        <property type="gene designation" value="nurf-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A5S9MQ08">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975:SF2">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
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    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DDT" evidence="14">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="1904"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="1964"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="2052"/>
            <end position="2122"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CAA0059157.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="F26H11.2s"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="A0A5S9MQ08"/>
        </source>
    </evidence>
    <sequence length="2199" mass="252781" checksum="8176F6AA5DA89444" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5S9MQ27</accession>
    <name>A0A5S9MQ27_CAEEL</name>
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        <submittedName>
            <fullName evidence="9">JNK-interacting protein 1</fullName>
        </submittedName>
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        <name evidence="11" type="ORF">F56D12.4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JIP scaffold family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="gene ID" value="WBGene00002176"/>
        <property type="gene designation" value="jip-1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAA0059167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F56D12.4e"/>
        </source>
    </evidence>
    <sequence length="527" mass="58865" checksum="03F7CCB8ACCC702D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-10-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8S4SK97</accession>
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        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7 9" type="primary">par-2</name>
        <name evidence="7" type="ORF">CELE_F58B6.3</name>
        <name evidence="9" type="ORF">F58B6.3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CAH2662236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001407526.1">
        <property type="nucleotide sequence ID" value="NM_001420607.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A8S4SK97"/>
    <dbReference type="GeneID" id="175275"/>
    <dbReference type="AGR" id="WB:WBGene00003917"/>
    <dbReference type="CTD" id="175275"/>
    <dbReference type="WormBase" id="F58B6.3d">
        <property type="protein sequence ID" value="CE54548"/>
        <property type="gene ID" value="WBGene00003917"/>
        <property type="gene designation" value="par-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16513">
        <property type="entry name" value="RING-HC_LONFs_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH2662236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F58B6.3d"/>
        </source>
    </evidence>
    <sequence length="581" mass="64535" checksum="667847E925CF080E" modified="2022-10-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>D3DEL7</accession>
    <name>D3DEL7_CAEEL</name>
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        <submittedName>
            <fullName evidence="9">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">jac-1</name>
        <name evidence="9" type="ORF">CELE_Y105C5B.21</name>
        <name evidence="11" type="ORF">Y105C5B.21</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBJ25105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255881.1">
        <property type="nucleotide sequence ID" value="NM_001268952.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3DEL7"/>
    <dbReference type="SMR" id="D3DEL7"/>
    <dbReference type="PeptideAtlas" id="D3DEL7"/>
    <dbReference type="GeneID" id="178451"/>
    <dbReference type="AGR" id="WB:WBGene00002175"/>
    <dbReference type="CTD" id="178451"/>
    <dbReference type="WormBase" id="Y105C5B.21c">
        <property type="protein sequence ID" value="CE24071"/>
        <property type="gene ID" value="WBGene00002175"/>
        <property type="gene designation" value="jac-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002175">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3DEL7">
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
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        <property type="term" value="P:cell-cell adhesion"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
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    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
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    </dbReference>
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        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0000316"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADHERENS JUNCTION PROTEIN P120"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="134"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="242"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="355"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="457"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="660"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="943"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="361"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="847"/>
            <end position="887"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1086"/>
            <end position="1181"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1093"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBJ25105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y105C5B.21c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="D3DEL7"/>
        </source>
    </evidence>
    <sequence length="1181" mass="130133" checksum="4C7E23F08D34358C" modified="2010-03-23" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-03-23" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>D3DEL8</accession>
    <name>D3DEL8_CAEEL</name>
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        <submittedName>
            <fullName evidence="9">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9 11" type="primary">jac-1</name>
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        <name evidence="11" type="ORF">Y105C5B.21</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CE44459"/>
        <property type="gene ID" value="WBGene00002175"/>
        <property type="gene designation" value="jac-1"/>
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    <dbReference type="OrthoDB" id="3245100at2759"/>
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    <dbReference type="GO" id="GO:0045296">
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
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    <dbReference type="InterPro" id="IPR028435">
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10372">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00041">
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="72"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="185"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="287"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="773"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="916"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="923"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBJ25106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y105C5B.21d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="D3DEL8"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111737" checksum="2E2373952396E5BD" modified="2010-03-23" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT08</accession>
    <name>D3YT08_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Inward rectifier potassium channel irk-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">irk-2</name>
        <name evidence="16" type="ORF">CELE_M02A10.2</name>
        <name evidence="18" type="ORF">M02A10.2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD62725.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256976.2">
        <property type="nucleotide sequence ID" value="NM_001270047.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT08"/>
    <dbReference type="SMR" id="D3YT08"/>
    <dbReference type="GeneID" id="191695"/>
    <dbReference type="KEGG" id="cel:CELE_M02A10.2"/>
    <dbReference type="AGR" id="WB:WBGene00002150"/>
    <dbReference type="CTD" id="191695"/>
    <dbReference type="WormBase" id="M02A10.2b">
        <property type="protein sequence ID" value="CE49104"/>
        <property type="gene ID" value="WBGene00002150"/>
        <property type="gene designation" value="irk-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002150">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT08">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000230">
        <property type="entry name" value="Inward Rectifying K (Potassium) channel family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="33"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="180"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD62725.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="M02A10.2b"/>
        </source>
    </evidence>
    <sequence length="461" mass="53020" checksum="FB61545C69800410" modified="2013-12-11" version="2">MLDIEEPLVKNKKYPFFKTPRLGGSRRIRNRLVQKQGLCNISLKNVPKQRRKYFSDIFTTVIEMKWRWCLLYFSLSFMISWSFFATVYFLIAKQHGDIEQIANATWTPCIVNVHNELNAFLFSFTTQTTIGYGFRYPTDACPLTIVTMCFQFMWGVMTQTLMAGIIFSKLARPIKRAATLIFSKNAVICLRDGKLCLLFRVGDMRKSSLAEAHVRLQMIKRCVTYEGELLPFHQFDMDVGYDQGLDRVFVIWPITICHEIDERSPLWEIGADDLKSAKFEIIAILEGVVESVGSTTQARTSYLPSEILWGHRFEKLVHYKKENGQYNIDFGKFHNVYSVNTPTCSAAEIERLRSEGIFNESEYQMYPPSDNKLNLLDNDEMSPVRDSIDLNQIQILRRDSDEDPDAGEESMELVDLGIHHKCSIRSQSPIINSTSHLLQPMHKNSCSVRRGSSTLNVSLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT09</accession>
    <name>D3YT09_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_ZK180.8</name>
        <name evidence="1 3" type="ORF">ZK180.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD73080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255263.1">
        <property type="nucleotide sequence ID" value="NM_001268334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT09"/>
    <dbReference type="GeneID" id="13192946"/>
    <dbReference type="KEGG" id="cel:CELE_ZK180.8"/>
    <dbReference type="AGR" id="WB:WBGene00195011"/>
    <dbReference type="CTD" id="13192946"/>
    <dbReference type="WormBase" id="ZK180.8a">
        <property type="protein sequence ID" value="CE44677"/>
        <property type="gene ID" value="WBGene00195011"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3415359_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00195011">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT09">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD73080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="ZK180.8a"/>
        </source>
    </evidence>
    <sequence length="27" mass="3466" checksum="8417A439DE69409F" modified="2010-04-20" version="1">MVKHSIMWFVFQVVKRTHFYFRRTFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT10</accession>
    <name>D3YT10_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C09G9.5</name>
        <name evidence="2" type="ORF">CELE_C09G9.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255351.1">
        <property type="nucleotide sequence ID" value="NM_001268422.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT10"/>
    <dbReference type="SMR" id="D3YT10"/>
    <dbReference type="GeneID" id="182465"/>
    <dbReference type="AGR" id="WB:WBGene00007495"/>
    <dbReference type="CTD" id="182465"/>
    <dbReference type="WormBase" id="C09G9.5b">
        <property type="protein sequence ID" value="CE44616"/>
        <property type="gene ID" value="WBGene00007495"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1373365_0_0_1"/>
    <dbReference type="OrthoDB" id="5799023at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007495">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT10">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C09G9.5b"/>
        </source>
    </evidence>
    <sequence length="181" mass="21024" checksum="33A3E91AC940423A" modified="2010-04-20" version="1">MSTISDKLSTDQNYFSMPTAPKPTKLCGYFGVHKIAIFGISFNAIFLFAFYVYGLIRLIQKTPKNYVEFIVICSILITMILTFSLMFIMAVFRARPKFLLPYMVLNTILFFAYAGAVIGSTITVPDEIREEVNGQDRSYKIVDIILLRVALLVFGAFEIFFIYSYIWTYIDVRRLYLFNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT11</accession>
    <name>D3YT11_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal_L30_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T11B7.2</name>
        <name evidence="2 4" type="ORF">T11B7.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255342.1">
        <property type="nucleotide sequence ID" value="NM_001268413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT11"/>
    <dbReference type="SMR" id="D3YT11"/>
    <dbReference type="GeneID" id="188408"/>
    <dbReference type="KEGG" id="cel:CELE_T11B7.2"/>
    <dbReference type="AGR" id="WB:WBGene00011707"/>
    <dbReference type="CTD" id="188408"/>
    <dbReference type="WormBase" id="T11B7.2b">
        <property type="protein sequence ID" value="CE44676"/>
        <property type="gene ID" value="WBGene00011707"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2499944_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011707">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT11">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T11B7.2b"/>
        </source>
    </evidence>
    <sequence length="86" mass="9895" checksum="A11BFF8E629C34AB" modified="2010-04-20" version="1">MVSEKCGDAESKRAPYPPPLRLARRVCYPQYTQKSLDMRAQEKLVGRKRDMKMARFLAKQAKESKEMVKKAAKETTEKTTKNDSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT12</accession>
    <name>D3YT12_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">50S ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_T11B7.2</name>
        <name evidence="2 4" type="ORF">T11B7.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255343.1">
        <property type="nucleotide sequence ID" value="NM_001268414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT12"/>
    <dbReference type="SMR" id="D3YT12"/>
    <dbReference type="GeneID" id="188408"/>
    <dbReference type="AGR" id="WB:WBGene00011707"/>
    <dbReference type="CTD" id="188408"/>
    <dbReference type="WormBase" id="T11B7.2c">
        <property type="protein sequence ID" value="CE44542"/>
        <property type="gene ID" value="WBGene00011707"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2499944_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011707">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT12">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T11B7.2c"/>
        </source>
    </evidence>
    <sequence length="49" mass="5658" checksum="E756F8B1A8D642CC" modified="2010-04-20" version="1">MRAQEKLVGRKRDMKMARFLAKQAKESKEMVKKAAKETTEKTTKNDSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-30" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>E1NZ06</accession>
    <name>E1NZ06_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Activin_recp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y17G7B.23</name>
        <name evidence="1 3" type="ORF">Y17G7B.23</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CBX25203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254330.1">
        <property type="nucleotide sequence ID" value="NM_001267401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1NZ06"/>
    <dbReference type="GeneID" id="3565812"/>
    <dbReference type="AGR" id="WB:WBGene00044030"/>
    <dbReference type="CTD" id="3565812"/>
    <dbReference type="WormBase" id="Y17G7B.23b">
        <property type="protein sequence ID" value="CE45398"/>
        <property type="gene ID" value="WBGene00044030"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1918933_0_0_1"/>
    <dbReference type="OrthoDB" id="5817023at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044030">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1NZ06">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBX25203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y17G7B.23b"/>
        </source>
    </evidence>
    <sequence length="132" mass="14162" checksum="473225631B00ED29" modified="2010-11-30" version="1">MTKRTNLDAMHTCKSCSEFDGNGDCSASTTGTCKGVYCTKTAGKMNGKSYETRGCSLVNPIGSNVCSWTDQTFNISMGIDQSAAARKKRGVSLPFRANQCYCQGELCNSSPPSQLASTLLLSIFSTSILIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-30" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>E1NZ08</accession>
    <name>E1NZ08_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Globin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">glb-29</name>
        <name evidence="7" type="ORF">CELE_Y17G7B.6</name>
        <name evidence="9" type="ORF">Y17G7B.6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CBX25205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254332.1">
        <property type="nucleotide sequence ID" value="NM_001267403.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1NZ08"/>
    <dbReference type="SMR" id="E1NZ08"/>
    <dbReference type="GeneID" id="189454"/>
    <dbReference type="AGR" id="WB:WBGene00012461"/>
    <dbReference type="CTD" id="189454"/>
    <dbReference type="WormBase" id="Y17G7B.6b">
        <property type="protein sequence ID" value="CE45391"/>
        <property type="gene ID" value="WBGene00012461"/>
        <property type="gene designation" value="glb-29"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5786609at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012461">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1NZ08">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF12">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="6">
        <location>
            <begin position="150"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBX25205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y17G7B.6b"/>
        </source>
    </evidence>
    <sequence length="301" mass="33877" checksum="E376E6E830A43535" modified="2010-11-30" version="1">MSLTNAECLTVHQQIPPQQQQQLYPNSMVPPSDRFTRSASSSPRRGGANGGGAVVVGPDGQLRRRESVLQMLNRIWKSDECTRRPSVQKSNALDVPTEPLSRQLSLSDTNVTPQISRCAKLNLSVKQKKLLRQSFNAMNSGGTFLKLMEKIFRRLETKCPDMRSIFLTTAFVNSLSRERQTPPLVKTEYDHCKCMVGIFERLIENLENINEQLTMIRHYGEKHAQMAESGFTGAMIEQFGEISVFVIGSQDVVKFNHETVKAWRLLLACVTDEMKVGFDRMSRINGRRNSCNPPSTVPSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-30" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>E1NZ09</accession>
    <name>E1NZ09_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Globin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">glb-29</name>
        <name evidence="6" type="ORF">CELE_Y17G7B.6</name>
        <name evidence="8" type="ORF">Y17G7B.6</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CBX25206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254333.1">
        <property type="nucleotide sequence ID" value="NM_001267404.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1NZ09"/>
    <dbReference type="SMR" id="E1NZ09"/>
    <dbReference type="GeneID" id="189454"/>
    <dbReference type="AGR" id="WB:WBGene00012461"/>
    <dbReference type="CTD" id="189454"/>
    <dbReference type="WormBase" id="Y17G7B.6c">
        <property type="protein sequence ID" value="CE45397"/>
        <property type="gene ID" value="WBGene00012461"/>
        <property type="gene designation" value="glb-29"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080529_0_0_1"/>
    <dbReference type="OrthoDB" id="5786609at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012461">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1NZ09">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF12">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="80"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBX25206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y17G7B.6c"/>
        </source>
    </evidence>
    <sequence length="231" mass="26349" checksum="CC65E788811E3902" modified="2010-11-30" version="1">MLNRIWKSDECTRRPSVQKSNALDVPTEPLSRQLSLSDTNVTPQISRCAKLNLSVKQKKLLRQSFNAMNSGGTFLKLMEKIFRRLETKCPDMRSIFLTTAFVNSLSRERQTPPLVKTEYDHCKCMVGIFERLIENLENINEQLTMIRHYGEKHAQMAESGFTGAMIEQFGEISVFVIGSQDVVKFNHETVKAWRLLLACVTDEMKVGFDRMSRINGRRNSCNPPSTVPSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-30" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>E1NZ10</accession>
    <name>E1NZ10_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">cdkl-1</name>
        <name evidence="14" type="ORF">CELE_Y42A5A.4</name>
        <name evidence="16" type="ORF">Y42A5A.4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBX25208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256289.1">
        <property type="nucleotide sequence ID" value="NM_001269360.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1NZ10"/>
    <dbReference type="SMR" id="E1NZ10"/>
    <dbReference type="GeneID" id="189841"/>
    <dbReference type="AGR" id="WB:WBGene00012779"/>
    <dbReference type="CTD" id="189841"/>
    <dbReference type="WormBase" id="Y42A5A.4b">
        <property type="protein sequence ID" value="CE45389"/>
        <property type="gene ID" value="WBGene00012779"/>
        <property type="gene designation" value="cdkl-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_24_1"/>
    <dbReference type="OMA" id="RRCDAMD"/>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="PhylomeDB" id="E1NZ10"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012779">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1NZ10">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07847">
        <property type="entry name" value="STKc_CDKL1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF222">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="135"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBX25208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="Y42A5A.4b"/>
        </source>
    </evidence>
    <sequence length="484" mass="55299" checksum="E6786D9CCCEE3177" modified="2010-11-30" version="1">MTPEEATKRAKGSSRTALSFLTAVKLETNTEKKSKDIRVNEPLSKLELLRIETSDTLCSSKENSLLLTSSDISRDPSKSPLNSLNRKKLSAPRLEKTKSDDMVFAEIEALTVMENNLFCSLRNSSKRRCEAMDKYDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRTVLHELEKNPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNASSAQLDFLQKCFEMSPDRRFSCSELMLHGIFSNWILRIRQDESTPTGLTSKRSPNYLPLLNGNSNNLVSKNFSLQGGNHGNNNNNGNGINRNFLPTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-30" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>E1NZ11</accession>
    <name>E1NZ11_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">cdkl-1</name>
        <name evidence="14" type="ORF">CELE_Y42A5A.4</name>
        <name evidence="16" type="ORF">Y42A5A.4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBX25209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001256290.1">
        <property type="nucleotide sequence ID" value="NM_001269361.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1NZ11"/>
    <dbReference type="SMR" id="E1NZ11"/>
    <dbReference type="GeneID" id="189841"/>
    <dbReference type="AGR" id="WB:WBGene00012779"/>
    <dbReference type="CTD" id="189841"/>
    <dbReference type="WormBase" id="Y42A5A.4c">
        <property type="protein sequence ID" value="CE45413"/>
        <property type="gene ID" value="WBGene00012779"/>
        <property type="gene designation" value="cdkl-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_24_1"/>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012779">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1NZ11">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07847">
        <property type="entry name" value="STKc_CDKL1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF222">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="34"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBX25209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="Y42A5A.4c"/>
        </source>
    </evidence>
    <sequence length="383" mass="44111" checksum="16A8BAB12948BAE9" modified="2010-11-30" version="1">MVFAEIEALTVMENNLFCSLRNSSKRRCEAMDKYDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRTVLHELEKNPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNASSAQLDFLQKCFEMSPDRRFSCSELMLHGIFSNWILRIRQDESTPTGLTSKRSPNYLPLLNGNSNNLVSKNFSLQGGNHGNNNNNGNGINRNFLPTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-30" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>E1NZ12</accession>
    <name>E1NZ12_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">wac-1.1</name>
        <name evidence="6" type="ORF">CELE_Y40B1A.3</name>
        <name evidence="8" type="ORF">Y40B1A.3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CBX25207.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001364671.1">
        <property type="nucleotide sequence ID" value="NM_001377669.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E1NZ12"/>
    <dbReference type="SMR" id="E1NZ12"/>
    <dbReference type="GeneID" id="189782"/>
    <dbReference type="AGR" id="WB:WBGene00012734"/>
    <dbReference type="CTD" id="189782"/>
    <dbReference type="WormBase" id="Y40B1A.3c">
        <property type="protein sequence ID" value="CE53974"/>
        <property type="gene ID" value="WBGene00012734"/>
        <property type="gene designation" value="wac-1.1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877333at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012734">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="E1NZ12">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038867">
        <property type="entry name" value="WAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911:SF6">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBX25207.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y40B1A.3c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="E1NZ12"/>
        </source>
    </evidence>
    <sequence length="515" mass="55694" checksum="B8A32D3D40F512BB" modified="2020-04-22" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G5EGR4</accession>
    <name>G5EGR4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Girdin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">mtcl-1</name>
        <name evidence="5" type="synonym">tag-241</name>
        <name evidence="5" type="ORF">C34E11.3</name>
        <name evidence="3" type="ORF">CELE_C34E11.3</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Bristol N2</strain>
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        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="G5EGR4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="entry name" value="MTCL1-3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15742:SF5">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
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            <end position="972"/>
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            <end position="1475"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1580"/>
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            <begin position="106"/>
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            <end position="485"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="518"/>
            <end position="642"/>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="751"/>
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            <begin position="1096"/>
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            <begin position="1181"/>
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    </feature>
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            <begin position="944"/>
            <end position="953"/>
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    </feature>
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            <begin position="954"/>
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    </feature>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CBJ25060.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="10">
        <location>
            <begin position="371"/>
            <end position="491"/>
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    </feature>
    <feature type="domain" description="Piwi" evidence="11">
        <location>
            <begin position="660"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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            <begin position="29"/>
            <end position="64"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070769"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50821"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAA93496.2"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
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        <citation type="journal article" date="2007" name="J. Biol. Chem." volume="282" first="31273" last="31288">
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            <authorList>
                <person name="Feng H."/>
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                <person name="Chen L."/>
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            <dbReference type="DOI" id="10.1074/jbc.M701532200"/>
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        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
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        <scope>MUTAGENESIS OF PRO-332; PRO-484; LYS-643; SER-925 AND SER-929</scope>
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        <citation type="journal article" date="2007" name="J. Biol. Chem." volume="282" first="31273" last="31288">
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        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-332; PRO-484; LYS-643; SER-925 AND SER-929</scope>
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        <citation type="journal article" date="2009" name="Immunity" volume="30" first="521" last="532">
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                <person name="Fu Y."/>
                <person name="Land M."/>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2007" name="J. Biol. Chem." volume="282" first="31273" last="31288">
            <title>Properties, regulation, and in vivo functions of a novel protein kinase D: Caenorhabditis elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and life span.</title>
            <authorList>
                <person name="Feng H."/>
                <person name="Ren M."/>
                <person name="Chen L."/>
                <person name="Rubin C.S."/>
            </authorList>
            <dbReference type="PubMed" id="17728253"/>
            <dbReference type="DOI" id="10.1074/jbc.M701532200"/>
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        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-332; PRO-484; LYS-643; SER-925 AND SER-929</scope>
        <scope>PHOSPHORYLATION AT SER-925 AND SER-929</scope>
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    <reference evidence="3" key="3">
        <citation type="journal article" date="2009" name="Immunity" volume="30" first="521" last="532">
            <title>Protein kinase D is an essential regulator of C. elegans innate immunity.</title>
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                <person name="Ren M."/>
                <person name="Feng H."/>
                <person name="Fu Y."/>
                <person name="Land M."/>
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        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2007" name="J. Biol. Chem." volume="282" first="31273" last="31288">
            <title>Properties, regulation, and in vivo functions of a novel protein kinase D: Caenorhabditis elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and life span.</title>
            <authorList>
                <person name="Feng H."/>
                <person name="Ren M."/>
                <person name="Chen L."/>
                <person name="Rubin C.S."/>
            </authorList>
            <dbReference type="PubMed" id="17728253"/>
            <dbReference type="DOI" id="10.1074/jbc.M701532200"/>
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        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF PRO-332; PRO-484; LYS-643; SER-925 AND SER-929</scope>
        <scope>PHOSPHORYLATION AT SER-925 AND SER-929</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2009" name="Immunity" volume="30" first="521" last="532">
            <title>Protein kinase D is an essential regulator of C. elegans innate immunity.</title>
            <authorList>
                <person name="Ren M."/>
                <person name="Feng H."/>
                <person name="Fu Y."/>
                <person name="Land M."/>
                <person name="Rubin C.S."/>
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            <dbReference type="DOI" id="10.1016/j.immuni.2009.03.007"/>
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        <scope>ACTIVITY REGULATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF SER-925 AND SER-929</scope>
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    <comment type="alternative products">
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        <citation type="journal article" date="1988" name="Cell" volume="54" first="5" last="16">
            <title>mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans.</title>
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                <person name="Chalfie M."/>
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            <dbReference type="DOI" id="10.1016/0092-8674(88)90174-2"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
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    <reference key="2">
        <citation type="journal article" date="1992" name="EMBO J." volume="11" first="4969" last="4979">
            <title>Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3.</title>
            <authorList>
                <person name="Xue D."/>
                <person name="Finney M."/>
                <person name="Ruvkun G."/>
                <person name="Chalfie M."/>
            </authorList>
            <dbReference type="PubMed" id="1361171"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SEQUENCE REVISION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
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    </reference>
    <reference key="4">
        <citation type="journal article" date="2000" name="EMBO J." volume="19" first="3694" last="3703">
            <title>Protein interaction surface of the POU transcription factor UNC-86 selectively used in touch neurons.</title>
            <authorList>
                <person name="Rohrig S."/>
                <person name="Rockelein I."/>
                <person name="Donhauser R."/>
                <person name="Baumeister R."/>
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            <dbReference type="DOI" id="10.1093/emboj/19.14.3694"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH UNC-86</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
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        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="4063" last="4068">
            <title>Caenorhabditis elegans aristaless/Arx gene alr-1 restricts variable gene expression.</title>
            <authorList>
                <person name="Topalidou I."/>
                <person name="van Oudenaarden A."/>
                <person name="Chalfie M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1101329108"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 69-TRP--ASP-321</scope>
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    <reference key="6">
        <citation type="journal article" date="2015" name="Dev. Cell" volume="34" first="206" last="219">
            <title>A competition mechanism for a homeotic neuron identity transformation in C. elegans.</title>
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                <person name="Gordon P.M."/>
                <person name="Hobert O."/>
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            <dbReference type="DOI" id="10.1016/j.devcel.2015.04.023"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 69-TRP--ASP-321</scope>
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    <reference key="7">
        <citation type="journal article" date="2017" name="Dev. Biol." volume="432" first="248" last="257">
            <title>Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron.</title>
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                <person name="Palumbos S.D."/>
                <person name="Novakovic M."/>
                <person name="Shang X."/>
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                <person name="Miller D.M. III"/>
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            <dbReference type="DOI" id="10.1016/j.ydbio.2017.10.009"/>
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        <scope>MUTAGENESIS OF 69-TRP--ASP-321</scope>
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    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="F01D4.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="F01D4.6c"/>
        </source>
    </evidence>
    <sequence length="278" mass="32051" checksum="ACB8AF1608E1BF8E" modified="1994-02-01" version="2">MDNRSYHENCVKCTICESPLAEKCFWKNGRIYCSQHYYKDHSIHRCAGCKKGVSPTDMVYKLKAGLVFHVECHCCSLCGRHLSPGEQILVDDTMMTVSCMSHYPPQMDDNAPGAIGSAVDIPSCSTENPIAPYPIDESFSSAFQVKKEVDAYGYNFEHYSFSDFCDDDSRMLKRRGPRTTIKQNQLDVLNEMFSNTPKPSKHARAKLALETGLSMRVIQVWFQNRRSKERRLKHLCNYLRHYEQRGLIPPPIHFRNEEMDTTDFNAFCGNFEEEDDED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>P34504-1</accession>
    <name>CHTB1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Chitin binding domain (ChtBD2) containing chtb-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">chtb-1</name>
        <name evidence="1" type="ORF">K04H4.2</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34504-1</id>
            <name>b</name>
            <sequence type="described" ref="VSP_012168 VSP_026511 VSP_026510 VSP_012169"/>
        </isoform>
        <isoform>
            <id>P34504-3</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P34504-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_012168 VSP_012169 VSP_026511 VSP_002449 VSP_026510"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001369839.1">
        <property type="nucleotide sequence ID" value="NM_001382960.1"/>
    </dbReference>
    <dbReference type="UCSC" id="K04H4.2a.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="WormBase" id="K04H4.2b">
        <property type="protein sequence ID" value="CE36653"/>
        <property type="gene ID" value="WBGene00010573"/>
        <property type="gene designation" value="chtb-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="K04H4.2c"/>
        </source>
    </evidence>
    <sequence length="788" mass="80380" checksum="C0D85035108B37C1" modified="2013-09-18" version="8" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>P34504-2</accession>
    <name>CHTB1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform a of Chitin binding domain (ChtBD2) containing chtb-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">chtb-1</name>
        <name evidence="1" type="ORF">K04H4.2</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P34504-2</id>
            <name>a</name>
            <sequence type="described" ref="VSP_026510 VSP_012168 VSP_002449 VSP_026511 VSP_012169"/>
        </isoform>
        <isoform>
            <id>P34504-1</id>
            <name>b</name>
            <sequence type="described" ref="VSP_026510 VSP_012169 VSP_026511 VSP_012168"/>
        </isoform>
        <isoform>
            <id>P34504-3</id>
            <name>c</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001369838.1">
        <property type="nucleotide sequence ID" value="NM_001382959.2"/>
    </dbReference>
    <dbReference type="WormBase" id="K04H4.2a">
        <property type="protein sequence ID" value="CE32463"/>
        <property type="gene ID" value="WBGene00010573"/>
        <property type="gene designation" value="chtb-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="K04H4.2c"/>
        </source>
    </evidence>
    <sequence length="628" mass="64137" checksum="15A4A67BF8383E9B" modified="2013-09-18" version="8" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1997-05-01" modified="2026-01-28" version="181" xmlns="https://uniprot.org/uniprot">
    <accession>P90973</accession>
    <name>P90973_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">ptl-1</name>
        <name evidence="9" type="ORF">CELE_F42G9.9</name>
        <name evidence="11" type="ORF">F42G9.9</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="1996" name="J. Cell Sci." volume="109" first="2661" last="2672">
            <title>PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans.</title>
            <authorList>
                <person name="Goedert M."/>
                <person name="Baur C.P."/>
                <person name="Ahringer J."/>
                <person name="Jakes R."/>
                <person name="Hasegawa M."/>
                <person name="Spillantini M.G."/>
                <person name="Smith M.J."/>
                <person name="Hill F."/>
            </authorList>
            <dbReference type="PubMed" id="8937984"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="U67967">
        <property type="protein sequence ID" value="AAC47829.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD61894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367354.1">
        <property type="nucleotide sequence ID" value="NM_001381708.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P90973"/>
    <dbReference type="GeneID" id="175230"/>
    <dbReference type="UCSC" id="F42G9.9c.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00004212"/>
    <dbReference type="CTD" id="175230"/>
    <dbReference type="WormBase" id="F42G9.9c">
        <property type="protein sequence ID" value="CE28322"/>
        <property type="gene ID" value="WBGene00004212"/>
        <property type="gene designation" value="ptl-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9378527at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004212">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="P90973">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF18">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC47829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD61894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="F42G9.9c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="P90973"/>
        </source>
    </evidence>
    <sequence length="413" mass="44873" checksum="ABCC293845BAE32B" modified="1997-05-01" version="1">MSTPQSEPGSEPGSPGENENSMETQYSQGSFPEVAVEPEPEPEPEPEPEPEPEPEPEPEPEPKPKPEVEPVPQPEPEPEYQPEPEPEPEVEPEPEPEPVPEPEPEPEPEPEPVVEKEEEVVVESPPREQEPEKSGKSKPSSPIPDAPTMEDIAPRELESLNFSETSGTSDQQADRIMQNNENERVEEKKQMSPTPSQPQHKTPQRSGIRPPTAILRQPKPIPASLPRPATATPSSQRAISTPRQTASTAPSPRPISKMSRERSDVQKSTSTRSIDNVGRMTPKVNAKFVNVKSKVGSVTNHKAGGGNVEIFSEKRLYNAQSKVGSLKNATHVAGGGNVQIENRKLDFSAASPKVGSKTNYQPAKSDVKIVSEKLTWQAKSKVGSMDNAAHKPAGGNVQRSGSKSTKNDDGHNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>P91082-2</accession>
    <name>EGL26_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoform b of Egg-laying defective protein 26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Putative acyltransferase egl-26</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">egl-26</name>
        <name evidence="4" type="synonym">cog-4</name>
        <name evidence="4" type="synonym">egl-48</name>
        <name evidence="4" type="ORF">C23H3.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2002" name="Dev. Biol." volume="241" first="247" last="258">
            <title>The Caenorhabditis elegans EGL-26 protein mediates vulval cell morphogenesis.</title>
            <authorList>
                <person name="Hanna-Rose W."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="11784109"/>
            <dbReference type="DOI" id="10.1006/dbio.2001.0514"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>MUTAGENESIS OF GLY-150; GLY-168 AND SER-275</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2007" name="Dev. Biol." volume="308" first="196" last="205">
            <title>Membrane localization of the NlpC/P60 family protein EGL-26 correlates with regulation of vulval cell morphogenesis in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Estes K.A."/>
                <person name="Kalamegham R."/>
                <person name="Hanna-Rose W."/>
            </authorList>
            <dbReference type="PubMed" id="17560977"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.05.020"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF HIS-166; GLY-168; HIS-178; CYS-261 AND SER-275</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P91082-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P91082-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061110"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="RefSeq" id="NP_001300512.1">
        <property type="nucleotide sequence ID" value="NM_001313583.2"/>
    </dbReference>
    <dbReference type="WormBase" id="C23H3.1b">
        <property type="protein sequence ID" value="CE50533"/>
        <property type="gene ID" value="WBGene00001193"/>
        <property type="gene designation" value="egl-26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="11784109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C23H3.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C23H3.1b"/>
        </source>
    </evidence>
    <sequence length="316" mass="35035" checksum="5CF2D620098189D7" modified="1997-05-01" version="1">MLTCIQPSSSSIGGFGKADDNVRILLMASVRNEFGDTSIFSRLGVTALGQHYVLVTKKKMFGGYTTHMITANMRNRPFISIPFKVSSGAQSIEESRDLISRLTTVLGRPGMFSFDDPPIGSQFPVGKELIQLDEVPVGVHDRQDKYLEKGDEVFCEVNVSGVKFYHSGIYAGDGMCYHFVCDAQSESFADALAVFSGASAHVVYDTWFEFVYALVEVSDVPPKIFRASHPLICRSGEQVVKYAEHLQRELENYDIRRCNCQHFSSECSTGVPFSYDMTSNFKYLACTVLKPTSTVVNAMTRPNRDRSSFASSSTSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>P91917-2</accession>
    <name>OLA1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ola-1</name>
        <name evidence="2" type="synonym">tag-210</name>
        <name evidence="2" type="ORF">W08E3.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2022" name="PLoS Genet." volume="18" first="e1010219" last="e1010219">
            <title>OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans.</title>
            <authorList>
                <person name="Aoki I."/>
                <person name="Jurado P."/>
                <person name="Nawa K."/>
                <person name="Kondo R."/>
                <person name="Yamashiro R."/>
                <person name="Matsuyama H.J."/>
                <person name="Ferrer I."/>
                <person name="Nakano S."/>
                <person name="Mori I."/>
            </authorList>
            <dbReference type="PubMed" id="35675262"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1010219"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P91917-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P91917-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_061661"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001252138.1">
        <property type="nucleotide sequence ID" value="NM_001265209.3"/>
    </dbReference>
    <dbReference type="WormBase" id="W08E3.3b">
        <property type="protein sequence ID" value="CE45385"/>
        <property type="gene ID" value="WBGene00012344"/>
        <property type="gene designation" value="ola-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="W08E3.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="W08E3.3b"/>
        </source>
    </evidence>
    <sequence length="125" mass="13951" checksum="999003688654A0A8" modified="1997-05-01" version="1">MPEDERQKYLKEQGVTSNLDKIVHTGYKALQLEYFFTSGEDEVKAWTIQVGTPAPKAAGRIHTDFEKGFIMAEVMKVADLIELGDEAKCKAGGKYRQQGKTYIVQDGDVIFFKFNAGAGLQAKKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q10669-2</accession>
    <name>MED23_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Mediator of RNA polymerase II transcription subunit 23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 23</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Mediator complex subunit sur-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sur-2</name>
        <name type="synonym">mdt-23</name>
        <name type="ORF">F39B2.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Genes Dev." volume="9" first="2251" last="2265">
            <title>sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.</title>
            <authorList>
                <person name="Singh N."/>
                <person name="Han M."/>
            </authorList>
            <dbReference type="PubMed" id="7557379"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>Bristol N2</strain>
            <tissue>Embryo</tissue>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Genes Dev." volume="16" first="1815" last="1827">
            <title>C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component.</title>
            <authorList>
                <person name="Howard R.M."/>
                <person name="Sundaram M.V."/>
            </authorList>
            <dbReference type="PubMed" id="12130541"/>
            <dbReference type="DOI" id="10.1101/gad.998402"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Curr. Biol." volume="14" first="1256" last="1261">
            <title>The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans.</title>
            <authorList>
                <person name="Nicholas H.R."/>
                <person name="Hodgkin J."/>
            </authorList>
            <dbReference type="PubMed" id="15268855"/>
            <dbReference type="DOI" id="10.1016/j.cub.2004.07.022"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-1347</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Development" volume="132" first="1885" last="1893">
            <title>Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans.</title>
            <authorList>
                <person name="Yoda A."/>
                <person name="Kouike H."/>
                <person name="Okano H."/>
                <person name="Sawa H."/>
            </authorList>
            <dbReference type="PubMed" id="15790964"/>
            <dbReference type="DOI" id="10.1242/dev.01776"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH LET-19</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Genes Dev." volume="19" first="1328" last="1340">
            <title>The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.</title>
            <authorList>
                <person name="Berset T.A."/>
                <person name="Hoier E.F."/>
                <person name="Hajnal A."/>
            </authorList>
            <dbReference type="PubMed" id="15901674"/>
            <dbReference type="DOI" id="10.1101/gad.333505"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q10669-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q10669-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_004435"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021463.1">
        <property type="nucleotide sequence ID" value="NM_001026292.5"/>
    </dbReference>
    <dbReference type="WormBase" id="F39B2.4b">
        <property type="protein sequence ID" value="CE28024"/>
        <property type="gene ID" value="WBGene00006349"/>
        <property type="gene designation" value="sur-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="1589" mass="184119" checksum="CAB44479C2812914" modified="1997-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q17827-2</accession>
    <name>PFD1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Probable prefoldin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">pfd-1</name>
        <name type="ORF">C08F8.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Dev. Biol." volume="313" first="320" last="334">
            <title>Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans.</title>
            <authorList>
                <person name="Lundin V.F."/>
                <person name="Srayko M."/>
                <person name="Hyman A.A."/>
                <person name="Leroux M.R."/>
            </authorList>
            <dbReference type="PubMed" id="18062952"/>
            <dbReference type="DOI" id="10.1016/j.ydbio.2007.10.022"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>VC1013</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q17827-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q17827-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_044042"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255541.1">
        <property type="nucleotide sequence ID" value="NM_001268612.4"/>
    </dbReference>
    <dbReference type="WormBase" id="C08F8.1b">
        <property type="protein sequence ID" value="CE45776"/>
        <property type="gene ID" value="WBGene00007443"/>
        <property type="gene designation" value="pfd-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <sequence length="80" mass="9440" checksum="946E0C551C429163" modified="1996-11-01" version="1">MRISESTKKNLVDLDENLKYYRSVGRMFLLTDKPAEISRHEAEAKQSKEKIEAIEKQKDYLEKGLVEAETNLRELIQSRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="179" xmlns="https://uniprot.org/uniprot">
    <accession>Q21774-2</accession>
    <name>PUR8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Adenylosuccinate lyase</fullName>
            <shortName>ASL</shortName>
            <ecNumber>4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Adenylosuccinase</fullName>
            <shortName>ASase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">adsl-1</name>
        <name evidence="1" type="ORF">R06C7.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2005-02" db="PDB data bank">
            <title>Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase.</title>
            <authorList>
                <consortium name="Southeast collaboratory for structural genomics (SECSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS)</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q21774-2</id>
            <name evidence="2">b</name>
            <sequence type="described" ref="VSP_016396 VSP_016397"/>
        </isoform>
        <isoform>
            <id>Q21774-1</id>
            <name evidence="1">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="4.3.2.2"/>
    <dbReference type="RefSeq" id="NP_001367034.1">
        <property type="nucleotide sequence ID" value="NM_001380665.2"/>
    </dbReference>
    <dbReference type="WormBase" id="R06C7.5b">
        <property type="protein sequence ID" value="CE32476"/>
        <property type="gene ID" value="WBGene00011064"/>
        <property type="gene designation" value="adsl-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="R06C7.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="R06C7.5b"/>
        </source>
    </evidence>
    <sequence length="370" mass="41496" checksum="C803E93C6C048BA1" modified="1996-11-01" version="1">MASEDKFESVLSTRYCKNSPLVSILSETNKATLWRQLWIWLAEAEKELGLKQVTQDAIDEMKSNRDVFDWPFIRSEERKLKHDVMAHNHAFGKLCPTAAGIIHLGATSCFVQDNADLIAYRDSIDHILKRFATVIDRLAAFSLKNKEVVTVGRTHYQTASLVTVGKRGVLWAQELLMAFQSLSEFRDKMRFRGIKGATGTQDSFLTLFAGDESKVEALDELVTKKANFSNRFLITGQTYSRQQDSQLVFSLSLLGAAAKKVCTDIRVLQAFGELLEPFEKDQIGSSAMPYKKNPMKSERCCALSRKLINAPQEALTILADQGLERTLDDSAGRRMLIPDVLLTAEALLTTLQVSVLKITSSKDLVYKQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-08" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q3HKB6</accession>
    <name>Q3HKB6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_T01D1.8</name>
        <name evidence="3 5" type="ORF">T01D1.8</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD71498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q3HKB6"/>
    <dbReference type="SMR" id="Q3HKB6"/>
    <dbReference type="UCSC" id="T01D1.8">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00044641"/>
    <dbReference type="WormBase" id="T01D1.8a">
        <property type="protein sequence ID" value="CE39175"/>
        <property type="gene ID" value="WBGene00044641"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154073_0_0_1"/>
    <dbReference type="OrthoDB" id="5919011at2759"/>
    <dbReference type="PhylomeDB" id="Q3HKB6"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044641">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q3HKB6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF34">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD71498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T01D1.8a"/>
        </source>
    </evidence>
    <sequence length="94" mass="10636" checksum="515B117AB8A289B0" modified="2005-11-08" version="1">MVNNCTISDSGEEEIGTRKIQIIDENGCSVFPNILPDISYQGDLSAGIKVHAFALDVDTTAVHFTCNIKMLFKDHEQCQRPRCGNQRRFSRYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-10" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q6A3Q2</accession>
    <name>Q6A3Q2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA-capping enzyme</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">mRNA 5'-triphosphate monophosphatase</fullName>
                <ecNumber evidence="12">3.6.1.74</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">mRNA 5'-phosphatase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">mRNA guanylyltransferase</fullName>
                <ecNumber evidence="12">2.7.7.50</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">GTP--RNA guanylyltransferase</fullName>
                <shortName evidence="12">GTase</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">cel-1</name>
        <name evidence="21" type="ORF">C03D6.3</name>
        <name evidence="19" type="ORF">CELE_C03D6.3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="12"/>
    <dbReference type="EC" id="2.7.7.50" evidence="12"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAH10769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001020980.1">
        <property type="nucleotide sequence ID" value="NM_001025809.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6A3Q2"/>
    <dbReference type="SMR" id="Q6A3Q2"/>
    <dbReference type="GeneID" id="172814"/>
    <dbReference type="AGR" id="WB:WBGene00000466"/>
    <dbReference type="CTD" id="172814"/>
    <dbReference type="WormBase" id="C03D6.3b">
        <property type="protein sequence ID" value="CE05197"/>
        <property type="gene ID" value="WBGene00000466"/>
        <property type="gene designation" value="cel-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021710_3_0_1"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000466">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6A3Q2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17664">
        <property type="entry name" value="Mce1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000291">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000047">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017074">
        <property type="entry name" value="mRNA_cap_enz_bifunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036958">
        <property type="entry name" value="mRNA_capping_HCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 12 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
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            <position position="304"/>
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            <name>GTP</name>
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            <begin position="345"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <begin position="465"/>
            <end position="467"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
            <begin position="541"/>
            <end position="546"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023134"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
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            <dbReference type="PIRSR" id="PIRSR036958-3"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
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            <dbReference type="PROSITE" id="PS50056"/>
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        <source>
            <dbReference type="EMBL" id="CAH10769.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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            <dbReference type="WormBase" id="C03D6.3b"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="WormBase" id="C23H3.9d"/>
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        <source>
            <dbReference type="PeptideAtlas" id="Q6A5A0"/>
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    </evidence>
    <sequence length="432" mass="47449" checksum="FC5CC4A4E6C03AD7" modified="2004-09-13" version="1">MKLFFIATVLLISGTHGATTEQLRQWILNNRESLNGQNDLAGSILRLFGWGSDKTTEATTTETTPEAPTTSEPRSHSRDARPTQRLPLTWSTVTPTAAPSQPIPTATSRKAPWYIKDRTAWPTYNRISAEKALQKTSTTQETTTSTTAQPTTTTTATTTTTTTPLPTTTTTQPTTTTTEPTTTTTTTEPTTTTPKVNSWAKLWTSTAEPKSYVNVTVLQAGSVRPLRDGQVEAVGAITLVNDNGYIVLIDTGASSDTERLLHSLAKESVTLDQIDSVVITHASPGHMGNMNFFAQKPILYHSMEYIGRHVTPTELKERPYRKLSGNVEVWKTPGHTQHDLSVLVHNVAGYGTMAIVGDLIPSEHLLSEKRDVMIEEGVWDNAIKRQNANLIVCMADWIVPGHGQPFRVLPNYRQKAGCTRLLAQRHLLNQAV</sequence>
</entry>
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            <fullName evidence="3">Serine or cysteine protease inhibitor</fullName>
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        <name evidence="4 6" type="primary">srp-7</name>
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    <organism evidence="3">
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        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="15448" last="15459">
            <title>SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins.</title>
            <authorList>
                <person name="Pak S.C."/>
                <person name="Kumar V."/>
                <person name="Tsu C."/>
                <person name="Luke C.J."/>
                <person name="Askew Y.S."/>
                <person name="Askew D.J."/>
                <person name="Mills D.R."/>
                <person name="Bromme D."/>
                <person name="Silverman G.A."/>
            </authorList>
            <dbReference type="PubMed" id="14739286"/>
            <dbReference type="DOI" id="10.1074/jbc.M400261200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS13533.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CCD68323.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="NP_001023824.1">
        <property type="nucleotide sequence ID" value="NM_001028653.5"/>
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        <property type="gene designation" value="srp-7"/>
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        <property type="component" value="Chromosome V"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
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        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
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        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
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        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="2">
        <location>
            <begin position="13"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD68323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F20D6.4c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q6QUQ5"/>
        </source>
    </evidence>
    <sequence length="365" mass="40513" checksum="0CE66D47BE680956" modified="2004-07-05" version="1">MALLLQSETDFGLGLLRQQNISESLAFSPLSIALALSLVHVAAKGETRDQIREALVKGSTDEQLEQHFANISAALLAAERGTEVKLANHVFTRAGFKIKQSYLDDVKKLYNAGASSLDFDNKEATAEAINNFVRENTGDHIKKIIGSDSINSDLVAVLTNALYFKADWQNKFKKDSTFKSEFFSSADSKREIDFLHASSVSRDYAENDQFQVLSLPYKDNTFALTIFLPKTRFGLTESLKTLDSATIQHLLSNVSSTSVNVQIPKWKIETKLGLEEALQSLGIKKAFDNDADLGNMADGLYVSKVTHKALIEVDEDGTVAVAATRCSIERCRKKMKENIEFHAEHPFFFILHHGTSYIFLGVFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="173" xmlns="https://uniprot.org/uniprot">
    <accession>Q6QUQ6</accession>
    <name>Q6QUQ6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine or cysteine protease inhibitor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">srp-7</name>
        <name evidence="4" type="ORF">CELE_F20D6.4</name>
        <name evidence="6" type="ORF">F20D6.4</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2003-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="15448" last="15459">
            <title>SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins.</title>
            <authorList>
                <person name="Pak S.C."/>
                <person name="Kumar V."/>
                <person name="Tsu C."/>
                <person name="Luke C.J."/>
                <person name="Askew Y.S."/>
                <person name="Askew D.J."/>
                <person name="Mills D.R."/>
                <person name="Bromme D."/>
                <person name="Silverman G.A."/>
            </authorList>
            <dbReference type="PubMed" id="14739286"/>
            <dbReference type="DOI" id="10.1074/jbc.M400261200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="AY525084">
        <property type="protein sequence ID" value="AAS13532.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD68322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023823.1">
        <property type="nucleotide sequence ID" value="NM_001028652.8"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6QUQ6"/>
    <dbReference type="SMR" id="Q6QUQ6"/>
    <dbReference type="MEROPS" id="I04.081"/>
    <dbReference type="GeneID" id="179195"/>
    <dbReference type="KEGG" id="cel:CELE_F20D6.4"/>
    <dbReference type="UCSC" id="F20D6.4d">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00005648"/>
    <dbReference type="CTD" id="179195"/>
    <dbReference type="WormBase" id="F20D6.4b">
        <property type="protein sequence ID" value="CE37003"/>
        <property type="gene ID" value="WBGene00005648"/>
        <property type="gene designation" value="srp-7"/>
    </dbReference>
    <dbReference type="OMA" id="MNEYDEH"/>
    <dbReference type="OrthoDB" id="9518664at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005648">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q6QUQ6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19581">
        <property type="entry name" value="serpinL_nematode"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF299">
        <property type="entry name" value="SERINE OR CYSTEINE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="2">
        <location>
            <begin position="13"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD68322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="F20D6.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="Q6QUQ6"/>
        </source>
    </evidence>
    <sequence length="366" mass="40363" checksum="6FEF5EDCD1E42CCD" modified="2004-07-05" version="1">MALLLQSETDFGLGLLRQQNISESLAFSPLSIALALSLVHVAAKGETRDQIREALVKGSTDEQLEQHFANISAALLAAERGTEVKLANHVFTRAGFKIKQSYLDDVKKLYNAGASSLDFDNKEATAEAINNFVRENTGDHIKKIIGSDSINSDLVAVLTNALYFKADWQNKFKKDSTFKSEFFSSADSKREIDFLHASSVSRDYAENDQFQVLSLPYKDNTFALTIFLPKTRFGLTESLKTLDSATIQHLLSNVSSTSVNVQIPKWKIETKLGLEEALQSLGIKKAFDNDADLGNMADGLYVSKVTHKALIEVDEEGTTAAAATVVSFVRKSARPSAIKPIVFQADHPFLFMLTQTNHPIFLGIHQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MQA7-2</accession>
    <name>ELT4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Probable transcription factor elt-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GATA-type domain-containing protein elt-4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">elt-4</name>
        <name evidence="3" type="ORF">C39B10.6</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2003" name="Genetics" volume="165" first="575" last="588">
            <title>The evolutionary duplication and probable demise of an endodermal GATA factor in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Fukushige T."/>
                <person name="Goszczynski B."/>
                <person name="Tian H."/>
                <person name="McGhee J.D."/>
            </authorList>
            <dbReference type="PubMed" id="14573471"/>
            <dbReference type="DOI" id="10.1093/genetics/165.2.575"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2010" name="J. Biol. Chem." volume="285" first="39536" last="39543">
            <title>A novel heme-responsive element mediates transcriptional regulation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Sinclair J."/>
                <person name="Hamza I."/>
            </authorList>
            <dbReference type="PubMed" id="20938051"/>
            <dbReference type="DOI" id="10.1074/jbc.m110.167619"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="1" key="4">
        <citation type="journal article" date="2014" name="Longev. Healthspan" volume="3" first="5" last="5">
            <title>Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan.</title>
            <authorList>
                <person name="Bansal A."/>
                <person name="Kwon E.S."/>
                <person name="Conte D. Jr."/>
                <person name="Liu H."/>
                <person name="Gilchrist M.J."/>
                <person name="MacNeil L.T."/>
                <person name="Tissenbaum H.A."/>
            </authorList>
            <dbReference type="PubMed" id="24834345"/>
            <dbReference type="DOI" id="10.1186/2046-2395-3-5"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative initiation"/>
        <isoform>
            <id>Q8MQA7-2</id>
            <name evidence="4">b</name>
            <sequence type="described" ref="VSP_061352 VSP_061353"/>
        </isoform>
        <isoform>
            <id>Q8MQA7-1</id>
            <name evidence="3">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367223.1">
        <property type="nucleotide sequence ID" value="NM_001381084.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C39B10.6b">
        <property type="protein sequence ID" value="CE51998"/>
        <property type="gene ID" value="WBGene00001252"/>
        <property type="gene designation" value="elt-4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="C39B10.6a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C39B10.6b"/>
        </source>
    </evidence>
    <sequence length="48" mass="5239" checksum="37F3194008023D7B" modified="2002-10-01" version="1">MLLIGNGLYAPIAMVRTQLSGEEKLKEIQSAMLVDYISSFITLPAPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q9GUN8</accession>
    <name>Q9GUN8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inappropriate Vulval cell Proliferation Homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">ivph-3</name>
        <name evidence="2" type="ORF">CELE_Y67D8C.3</name>
        <name evidence="4" type="ORF">Y67D8C.3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD74092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001023557.1">
        <property type="nucleotide sequence ID" value="NM_001028386.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9GUN8"/>
    <dbReference type="SMR" id="Q9GUN8"/>
    <dbReference type="GeneID" id="177086"/>
    <dbReference type="KEGG" id="cel:CELE_Y67D8C.3"/>
    <dbReference type="UCSC" id="Y67D8C.3b.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022067"/>
    <dbReference type="CTD" id="177086"/>
    <dbReference type="WormBase" id="Y67D8C.3a">
        <property type="protein sequence ID" value="CE29902"/>
        <property type="gene ID" value="WBGene00022067"/>
        <property type="gene designation" value="ivph-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020701_0_0_1"/>
    <dbReference type="OrthoDB" id="5784093at2759"/>
    <dbReference type="PhylomeDB" id="Q9GUN8"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022067">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9GUN8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040027">
        <property type="term" value="P:negative regulation of vulval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040129">
        <property type="entry name" value="Lin-15B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22716">
        <property type="entry name" value="ETS CLASS TRANSCRIPTION FACTOR-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22716:SF5">
        <property type="entry name" value="INAPPROPRIATE VULVAL CELL PROLIFERATION HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD74092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y67D8C.3a"/>
        </source>
    </evidence>
    <sequence length="662" mass="75539" checksum="9D52903BF230AED1" modified="2001-12-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2025-10-08" version="182" xmlns="https://uniprot.org/uniprot">
    <accession>Q9GUP2</accession>
    <name>Q9GUP2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">eel-1</name>
        <name evidence="16" type="ORF">CELE_Y67D8C.5</name>
        <name evidence="18" type="ORF">Y67D8C.5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD74094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_500284.2">
        <property type="nucleotide sequence ID" value="NM_067883.4"/>
    </dbReference>
    <dbReference type="SMR" id="Q9GUP2"/>
    <dbReference type="PeptideAtlas" id="Q9GUP2"/>
    <dbReference type="GeneID" id="177084"/>
    <dbReference type="UCSC" id="Y67D8C.5">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022069"/>
    <dbReference type="CTD" id="177084"/>
    <dbReference type="WormBase" id="Y67D8C.5a">
        <property type="protein sequence ID" value="CE31665"/>
        <property type="gene ID" value="WBGene00022069"/>
        <property type="gene designation" value="eel-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="PhylomeDB" id="Q9GUP2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022069">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 6 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9GUP2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045167">
        <property type="term" value="P:asymmetric protein localization involved in cell fate determination"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031581">
        <property type="term" value="P:hemidesmosome assembly"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042770">
        <property type="term" value="P:signal transduction in response to DNA damage"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14306">
        <property type="entry name" value="UBA_VP13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000126">
        <property type="entry name" value="Enhancer of EfL-1 mutant phenotype"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041969">
        <property type="entry name" value="VP13D_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="14">
        <location>
            <begin position="1434"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="3841"/>
            <end position="4177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="491"/>
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        <location>
            <begin position="808"/>
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        <location>
            <begin position="1118"/>
            <end position="1139"/>
        </location>
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            <begin position="2032"/>
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        <location>
            <begin position="2371"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2797"/>
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        <location>
            <begin position="3001"/>
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        </location>
    </feature>
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        <location>
            <begin position="3592"/>
            <end position="3660"/>
        </location>
    </feature>
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        <location>
            <begin position="2177"/>
            <end position="2216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="530"/>
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            <begin position="544"/>
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        <location>
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        <location>
            <begin position="2458"/>
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        <location>
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        <location>
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        <location>
            <begin position="2835"/>
            <end position="2851"/>
        </location>
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        <location>
            <begin position="2852"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2889"/>
            <end position="2899"/>
        </location>
    </feature>
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        <location>
            <begin position="2900"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2923"/>
            <end position="2934"/>
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        <location>
            <begin position="3010"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="3600"/>
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        <location>
            <begin position="3613"/>
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    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="4144"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
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        <source>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
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    <evidence type="ECO:0000256" key="12">
        <source>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD74094.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="Y67D8C.5a"/>
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    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="Q9GUP2"/>
        </source>
    </evidence>
    <sequence length="4177" mass="465411" checksum="9C32EF90AB87FD58" modified="2002-10-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XWE8</accession>
    <name>Q9XWE8_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Putative inositol monophosphatase 3</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inositol-1(or 4)-monophosphatase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Myo-inositol monophosphatase A3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">gpap-1</name>
        <name evidence="18" type="ORF">CELE_Y6B3B.5</name>
        <name evidence="20" type="ORF">Y6B3B.5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CAA21725.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T27326">
        <property type="entry name" value="T27326"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001359521.1">
        <property type="nucleotide sequence ID" value="NM_001373655.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XWE8"/>
    <dbReference type="SMR" id="Q9XWE8"/>
    <dbReference type="GeneID" id="173241"/>
    <dbReference type="UCSC" id="Y6B3B.5b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012390"/>
    <dbReference type="CTD" id="173241"/>
    <dbReference type="WormBase" id="Y6B3B.5a">
        <property type="protein sequence ID" value="CE37581"/>
        <property type="gene ID" value="WBGene00012390"/>
        <property type="gene designation" value="gpap-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034742_1_0_1"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012390">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XWE8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052834">
        <property type="term" value="F:inositol monophosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01640">
        <property type="entry name" value="IPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000012">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000007">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF4">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAA21725.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WormBase" id="Y6B3B.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XWE8"/>
        </source>
    </evidence>
    <sequence length="339" mass="37889" checksum="8C15ED569A0412FF" modified="2004-11-23" version="3">MQVKLHPKNTFTIIMVVGFLYLAYLIFFESGDGMPEIDVDLKDVISYAVLAIEMGGHAVMKVNEEKNLNAAAKGLTDEGKEELLTRADLISNHLILDILQRFPQLQIVSEEKKSEFSEREIEPYRLDNYAVWQSVKEILDKIPSRRLQLSDVRVFVDPLDATQEFTEGLTEYVTVMACIVLDAEPIFGAIYRPFFNETIFGLQGFGVITSDGVRLNPIEDSKTAKKVVVSRSHAGKVKEIVEKVYGDKMNIEPAGGSGYKTLRLVNGTAELYLHTTAIKKWDTCAGDAILRTMGGAMLDLEGQPLRYSSADPLLNKKGLLATVRNPYSYLNKFQGIQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXI2</accession>
    <name>Q9XXI2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Globin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">glb-29</name>
        <name evidence="6" type="ORF">CELE_Y17G7B.6</name>
        <name evidence="8" type="ORF">Y17G7B.6</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAA19459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T26505">
        <property type="entry name" value="T26505"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254334.1">
        <property type="nucleotide sequence ID" value="NM_001267405.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XXI2"/>
    <dbReference type="SMR" id="Q9XXI2"/>
    <dbReference type="GeneID" id="189454"/>
    <dbReference type="UCSC" id="Y17G7B.6">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012461"/>
    <dbReference type="CTD" id="189454"/>
    <dbReference type="WormBase" id="Y17G7B.6d">
        <property type="protein sequence ID" value="CE19039"/>
        <property type="gene ID" value="WBGene00012461"/>
        <property type="gene designation" value="glb-29"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5786609at2759"/>
    <dbReference type="PhylomeDB" id="Q9XXI2"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012461">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XXI2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF12">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="65"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA19459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y17G7B.6d"/>
        </source>
    </evidence>
    <sequence length="216" mass="24604" checksum="0A1396EA24ECEA34" modified="1999-11-01" version="1">MLTLLGKIAHFREPLSRQLSLSDTNVTPQISRCAKLNLSVKQKKLLRQSFNAMNSGGTFLKLMEKIFRRLETKCPDMRSIFLTTAFVNSLSRERQTPPLVKTEYDHCKCMVGIFERLIENLENINEQLTMIRHYGEKHAQMAESGFTGAMIEQFGEISVFVIGSQDVVKFNHETVKAWRLLLACVTDEMKVGFDRMSRINGRRNSCNPPSTVPSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXJ5</accession>
    <name>Q9XXJ5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="5 6">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
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            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T26339"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001269798.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XXJ5"/>
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    <dbReference type="GeneID" id="190827"/>
    <dbReference type="KEGG" id="cel:CELE_Y102A5B.2"/>
    <dbReference type="UCSC" id="Y102A5B.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013608"/>
    <dbReference type="CTD" id="190827"/>
    <dbReference type="WormBase" id="Y102A5B.2a">
        <property type="protein sequence ID" value="CE35641"/>
        <property type="gene ID" value="WBGene00013608"/>
        <property type="gene designation" value="clec-35"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037161_1_0_1"/>
    <dbReference type="OrthoDB" id="5779307at2759"/>
    <dbReference type="PhylomeDB" id="Q9XXJ5"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013608">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XXJ5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050976">
        <property type="entry name" value="Snaclec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22991:SF44">
        <property type="entry name" value="C-TYPE LECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22991">
        <property type="entry name" value="PROTEIN CBG13490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="101"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="236"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA19438.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y102A5B.2a"/>
        </source>
    </evidence>
    <sequence length="355" mass="39432" checksum="40457BC405F94627" modified="2004-07-05" version="2">MMFEKLHRFLQLHWKIILFGVIFEILITIGAVRLTYILSKPFCETDTITSSAIQTSTVSSFATTSTGSDTSSNSTTTRPLSTSTEPAPPFTLDCTIGFTHINGKCWFLIPIRRTREDADAVCMGYGGSTLFSIRNEQENTAALDYLSNAGVNYVWTGLICAGNTSSSCTWDMKSGSAADYDNFANGFPNETNTSCVYFITSGPDAGQWKSGSCNQTMGFMCELPPTIHDGSCDYNYNNQCYLRYNTPHNIPDAQEICKTRCANLVSISSANENRFIRSLFTTQGYVLLGAAVIYYDDIYWLDGSPAVYNYIERYQHGACLLLNVNWVYITDGAWYTERCTTPGKFLCKRPAGTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXK5</accession>
    <name>Q9XXK5_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Suppressor of Constitutive Dauer formation</fullName>
        </submittedName>
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    <gene>
        <name evidence="3 5" type="primary">scd-1</name>
        <name evidence="3" type="ORF">CELE_H20J18.1</name>
        <name evidence="5" type="ORF">H20J18.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAA18898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T23107">
        <property type="entry name" value="T23107"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_171974.8"/>
    </dbReference>
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    <dbReference type="DIP" id="DIP-26999N"/>
    <dbReference type="PeptideAtlas" id="Q9XXK5"/>
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    <dbReference type="AGR" id="WB:WBGene00004739"/>
    <dbReference type="CTD" id="181408"/>
    <dbReference type="WormBase" id="H20J18.1a">
        <property type="protein sequence ID" value="CE18818"/>
        <property type="gene ID" value="WBGene00004739"/>
        <property type="gene designation" value="scd-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ST63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NCMSHAK"/>
    <dbReference type="OrthoDB" id="10017659at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004739">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XXK5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="864"/>
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        </location>
    </feature>
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            <end position="202"/>
        </location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <end position="358"/>
        </location>
    </feature>
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        <location>
            <begin position="650"/>
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        </location>
    </feature>
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        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
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        <location>
            <begin position="688"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAA18898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="H20J18.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XXK5"/>
        </source>
    </evidence>
    <sequence length="947" mass="101560" checksum="B14CE674DEE5E9D8" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XXL9</accession>
    <name>Q9XXL9_CAEEL</name>
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        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CELE_ZK1025.4</name>
        <name evidence="7 9" type="ORF">ZK1025.4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
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        <property type="protein sequence ID" value="CAA18367.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T27653"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001047253.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XXL9"/>
    <dbReference type="GeneID" id="191493"/>
    <dbReference type="KEGG" id="cel:CELE_ZK1025.4"/>
    <dbReference type="UCSC" id="ZK1025.4a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00014184"/>
    <dbReference type="CTD" id="191493"/>
    <dbReference type="WormBase" id="ZK1025.4a">
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        <property type="gene ID" value="WBGene00014184"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048942_0_0_1"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014184">
        <property type="expression patterns" value="Expressed in larva"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XXL9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47024">
        <property type="entry name" value="BIOFILM ABSENT ON HEAD (AFTER YERSINIA EXPOSURE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47024:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAA18367.2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="ZK1025.4a"/>
        </source>
    </evidence>
    <sequence length="402" mass="46365" checksum="A533E42669E09C95" modified="2005-10-11" version="2">MKFSFDFLPVCLYFTIFYVYPRFQNQSLLKNQINASFPITFYHKVYVDYRTSPPRLRIFSLNPCIKASNYLLVHVYYNGTITKLKLNGYSFGFYEGNCPPVYGPARNCFYVPHHFYGVLPENGVVQKVSIQLGHREAFLSEIVEIGKSYEKGLTVCLQIVYYYSQWQNVILYIEAWRAQGATRFIVYFHSATQDTKKVLDYYEKLGLIELRPWPNVGALSSYIAPYHPKIDDSVFIIASHIALQVCSLEIRTELGIVADFDEVMVPGDGSVLEYAELVMAGKNIGALLFENTHVGLEPNIYTNDFSGMKTLTFINIFAPPKYIFNTSLIDICETHSPGKFLHNSTTTLFSNGTVLHFRFNIKEIKANVVEKPYRFFPNSTEGHIWNMHDTVRTVWNFLFFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>S6FCW6</accession>
    <name>S6FCW6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">pde-4</name>
        <name evidence="10" type="ORF">CELE_R153.1</name>
        <name evidence="12" type="ORF">R153.1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CDG24082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293472.1">
        <property type="nucleotide sequence ID" value="NM_001306543.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6FCW6"/>
    <dbReference type="SMR" id="S6FCW6"/>
    <dbReference type="GeneID" id="174235"/>
    <dbReference type="AGR" id="WB:WBGene00020114"/>
    <dbReference type="CTD" id="174235"/>
    <dbReference type="WormBase" id="R153.1h">
        <property type="protein sequence ID" value="CE48488"/>
        <property type="gene ID" value="WBGene00020114"/>
        <property type="gene designation" value="pde-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020114">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6FCW6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000001">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040844">
        <property type="entry name" value="PDE4_UCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18100">
        <property type="entry name" value="PDE4_UCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0114">cAMP</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="278"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="357"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDG24082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="R153.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="S6FCW6"/>
        </source>
    </evidence>
    <sequence length="624" mass="70887" checksum="9A2070ACDAF2D69E" modified="2013-10-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>S6FD44</accession>
    <name>S6FD44_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Calcitonin receptor-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">pdfr-1</name>
        <name evidence="17" type="ORF">C13B9.4</name>
        <name evidence="15" type="ORF">CELE_C13B9.4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDG24148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293621.1">
        <property type="nucleotide sequence ID" value="NM_001306692.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6FD44"/>
    <dbReference type="SMR" id="S6FD44"/>
    <dbReference type="GeneID" id="175942"/>
    <dbReference type="AGR" id="WB:WBGene00015735"/>
    <dbReference type="CTD" id="175942"/>
    <dbReference type="WormBase" id="C13B9.4e">
        <property type="protein sequence ID" value="CE48427"/>
        <property type="gene ID" value="WBGene00015735"/>
        <property type="gene designation" value="pdfr-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002753_4_2_1"/>
    <dbReference type="OrthoDB" id="5967113at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015735">
        <property type="expression patterns" value="Expressed in larva and 14 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6FD44">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15261">
        <property type="entry name" value="7tmB1_PDFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000029">
        <property type="entry name" value="PDF receptor isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF17">
        <property type="entry name" value="PDF RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="51"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="157"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="462"/>
            <end position="497"/>
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</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
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</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <property type="entry name" value="KCMF1/Dystrophin"/>
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        <property type="entry name" value="Spectrin/alpha-actinin"/>
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    <dbReference type="InterPro" id="IPR056503">
        <property type="entry name" value="Spectrin_Dys-1"/>
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    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="Znf_ZZ"/>
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        <property type="entry name" value="Znf_ZZ_sf"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
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    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="1877"/>
            <end position="1911"/>
        </location>
    </feature>
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            <begin position="509"/>
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    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1430"/>
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        <location>
            <begin position="1714"/>
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            <begin position="1221"/>
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            <begin position="2398"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
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        <source>
            <dbReference type="PROSITE" id="PS50135"/>
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        <source>
            <dbReference type="EMBL" id="CDK13555.1"/>
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    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WormBase" id="F15D3.1j"/>
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    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PeptideAtlas" id="V6CJE3"/>
        </source>
    </evidence>
    <sequence length="2504" mass="284608" checksum="00E47452AF8290F5" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>V6CJE7</accession>
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        <submittedName>
            <fullName evidence="13">Fork-head domain-containing protein</fullName>
        </submittedName>
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        <name evidence="13 15" type="primary">fkh-7</name>
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    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">Bristol N2</strain>
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        <subcellularLocation>
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        <property type="gene ID" value="WBGene00001439"/>
        <property type="gene designation" value="fkh-7"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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        <location>
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    </feature>
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        <location>
            <begin position="644"/>
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        <location>
            <begin position="17"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="491"/>
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        <location>
            <begin position="514"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50039"/>
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    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDK13560.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="V6CJE7"/>
        </source>
    </evidence>
    <sequence length="745" mass="81418" checksum="B5A390790EA4E545" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>V6CJF0</accession>
    <name>V6CJF0_CAEEL</name>
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        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">eif-4a3</name>
        <name evidence="10" type="synonym">eif-4A3</name>
        <name evidence="10" type="ORF">CELE_Y65B4A.6</name>
        <name evidence="12" type="ORF">Y65B4A.6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293247.1">
        <property type="nucleotide sequence ID" value="NM_001306318.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CJF0"/>
    <dbReference type="SMR" id="V6CJF0"/>
    <dbReference type="PeptideAtlas" id="V6CJF0"/>
    <dbReference type="GeneID" id="190485"/>
    <dbReference type="KEGG" id="cel:CELE_Y65B4A.6"/>
    <dbReference type="AGR" id="WB:WBGene00022029"/>
    <dbReference type="CTD" id="190485"/>
    <dbReference type="WormBase" id="Y65B4A.6b">
        <property type="protein sequence ID" value="CE49411"/>
        <property type="gene ID" value="WBGene00022029"/>
        <property type="gene designation" value="eif-4A3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022029">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CJF0">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="135"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDK13565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y65B4A.6b"/>
        </source>
    </evidence>
    <sequence length="279" mass="32382" checksum="DCA5CC69D7BA583F" modified="2014-02-19" version="1">MNVQCHACIGGTNLGEDIRKLDYGQHVVSGTPGRVFDMIRRRNLRTRAIKLLVLDEADEMLNKGFKEQLYDIYRYLPPGAQVVLLSATLPHEILEMTSKFMTDPIRILVKRDELTLEGIKQFFVAVDREEWKFDTLIDLYDTLTITQAVLFCNTRRKVDWLTDKMKEANFTVSSMHGDMEQKDRDEVMKEFRAGTTRVLISTDVWARGLDVPQVSLVINYDLPNNRELYIHRIGRSGRFGRKGVAINFVKQDDVRILRDIEQYYSTQIDEMPMNIADII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>V6CJF5</accession>
    <name>V6CJF5_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">unc-77</name>
        <name evidence="27" type="ORF">C11D2.6</name>
        <name evidence="25" type="ORF">CELE_C11D2.6</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293818.1">
        <property type="nucleotide sequence ID" value="NM_001306889.3"/>
    </dbReference>
    <dbReference type="SMR" id="V6CJF5"/>
    <dbReference type="GeneID" id="177379"/>
    <dbReference type="KEGG" id="cel:CELE_C11D2.6"/>
    <dbReference type="AGR" id="WB:WBGene00006809"/>
    <dbReference type="CTD" id="177379"/>
    <dbReference type="WormBase" id="C11D2.6g">
        <property type="protein sequence ID" value="CE49437"/>
        <property type="gene ID" value="WBGene00006809"/>
        <property type="gene designation" value="unc-77"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006809">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CJF5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000089">
        <property type="entry name" value="Four domain-type voltage-gated ion channel alpha-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000080">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000060">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000061">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000066">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000030">
        <property type="entry name" value="sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000032">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000034">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF2">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="924"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1004"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1066"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1180"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1261"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1293"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1333"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1367"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1405"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1490"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="81"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="429"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="930"/>
            <end position="1210"/>
        </location>
    </feature>
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            <begin position="1259"/>
            <end position="1527"/>
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        <location>
            <begin position="825"/>
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        </location>
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            <begin position="1693"/>
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        <location>
            <begin position="1702"/>
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            <begin position="1718"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00061650"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Pfam" id="PF00520"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDK13570.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="C11D2.6g"/>
        </source>
    </evidence>
    <sequence length="1832" mass="211811" checksum="DBA97458890BB4A1" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>V6CJF9</accession>
    <name>V6CJF9_CAEEL</name>
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        <recommendedName>
            <fullName evidence="19">Sodium leak channel NALCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sodium leak channel non-selective protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage gated channel-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">unc-77</name>
        <name evidence="27" type="ORF">C11D2.6</name>
        <name evidence="25" type="ORF">CELE_C11D2.6</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the NALCN family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293823.1">
        <property type="nucleotide sequence ID" value="NM_001306894.3"/>
    </dbReference>
    <dbReference type="SMR" id="V6CJF9"/>
    <dbReference type="GeneID" id="177379"/>
    <dbReference type="AGR" id="WB:WBGene00006809"/>
    <dbReference type="CTD" id="177379"/>
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        <property type="protein sequence ID" value="CE49197"/>
        <property type="gene ID" value="WBGene00006809"/>
        <property type="gene designation" value="unc-77"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069766at2759"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006809">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CJF9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000089">
        <property type="entry name" value="Four domain-type voltage-gated ion channel alpha-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sodium leak channel non-selective protein"/>
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    </dbReference>
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        <property type="entry name" value="Sodium leak channel non-selective protein"/>
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        <property type="entry name" value="Sodium leak channel non-selective protein"/>
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        <property type="entry name" value="Sodium leak channel non-selective protein"/>
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        <property type="match status" value="4"/>
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    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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    </dbReference>
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        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="1054"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061650"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074738"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081688"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082498"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDK13575.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WormBase" id="C11D2.6l"/>
        </source>
    </evidence>
    <sequence length="1820" mass="210274" checksum="CBDD9768FFBDB12B" modified="2014-02-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-09-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A061AJC4</accession>
    <name>A0A061AJC4_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">zim-3</name>
        <name evidence="2" type="ORF">CELE_T07G12.11</name>
        <name evidence="4" type="ORF">T07G12.11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDR32756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293985.1">
        <property type="nucleotide sequence ID" value="NM_001307056.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A061AJC4"/>
    <dbReference type="SMR" id="A0A061AJC4"/>
    <dbReference type="GeneID" id="188246"/>
    <dbReference type="KEGG" id="cel:CELE_T07G12.11"/>
    <dbReference type="AGR" id="WB:WBGene00011601"/>
    <dbReference type="CTD" id="188246"/>
    <dbReference type="WormBase" id="T07G12.11b">
        <property type="protein sequence ID" value="CE21166"/>
        <property type="gene ID" value="WBGene00011601"/>
        <property type="gene designation" value="zim-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007005_0_0_1"/>
    <dbReference type="OrthoDB" id="5816341at2759"/>
    <dbReference type="PhylomeDB" id="A0A061AJC4"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011601">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A061AJC4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053360">
        <property type="entry name" value="Zinc_finger_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36945:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36945">
        <property type="entry name" value="HIGH INCIDENCE OF MALES (INCREASED X CHROMOSOME LOSS)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDR32756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="T07G12.11b"/>
        </source>
    </evidence>
    <sequence length="575" mass="65235" checksum="63C02089322CCB48" modified="2014-09-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARQ0</accession>
    <name>A0A0K3ARQ0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">etr-1</name>
        <name evidence="4" type="ORF">CELE_T01D1.2</name>
        <name evidence="6" type="ORF">T01D1.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368533.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARQ0"/>
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    <dbReference type="GeneID" id="173401"/>
    <dbReference type="AGR" id="WB:WBGene00001340"/>
    <dbReference type="CTD" id="173401"/>
    <dbReference type="WormBase" id="T01D1.2x">
        <property type="protein sequence ID" value="CE50653"/>
        <property type="gene ID" value="WBGene00001340"/>
        <property type="gene designation" value="etr-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001340">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARQ0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12362">
        <property type="entry name" value="RRM3_CELF1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000569">
        <property type="entry name" value="ELAV-Type RNA binding-protein family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="120"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CTQ86527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="T01D1.2x"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARQ0"/>
        </source>
    </evidence>
    <sequence length="205" mass="21407" checksum="97270DD6AF55AEAA" modified="2015-11-11" version="1">MAAQNQFDAITMAQIAHQQQMLALQGFAVQQGAPSQQQQGLAGGMAGAKTTSPVAASLANHQQIALTPFAGGAAALDHFQAMQQYALLANLQATGGVGVQATTSAAQMVGNGDVKGPDGANLFIYHLPQDFGDSDLINTFAPFGGILSAKVFIDKVTNLSKCFGFVSYENAQSATNAISAMNGFQIGSKRLKVQLKVDRGNPYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARQ7</accession>
    <name>A0A0K3ARQ7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">egl-8</name>
        <name evidence="17" type="ORF">B0348.4</name>
        <name evidence="15" type="ORF">CELE_B0348.4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="8"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368553.1">
        <property type="nucleotide sequence ID" value="NM_001380577.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0K3ARQ7"/>
    <dbReference type="GeneID" id="178537"/>
    <dbReference type="AGR" id="WB:WBGene00001177"/>
    <dbReference type="CTD" id="178537"/>
    <dbReference type="WormBase" id="B0348.4g">
        <property type="protein sequence ID" value="CE50641"/>
        <property type="gene ID" value="WBGene00001177"/>
        <property type="gene designation" value="egl-8"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001177">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARQ7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16200">
        <property type="entry name" value="EFh_PI-PLCbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1230.10:FF:000006">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000047">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000093">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLC-beta_C"/>
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        <ligand>
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        <source>
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        <source>
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    </evidence>
    <sequence length="1394" mass="157178" checksum="06DA1CB1AC4576CD" modified="2015-11-11" version="1"> </sequence>
</entry>
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    <accession>A0A0K3ARQ9</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="T25D3.4c"/>
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    </evidence>
    <sequence length="440" mass="47760" checksum="8ACDA4B85DD42F6D" modified="2015-11-11" version="1">MNGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPIPCLKISPWWYFSLFSLSGLFSVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPESLPSRRNTGSVSQITPNEVFNWQSADPFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLKLVVGFSPEAVAMYIGLVGILSVVAQTGFLHCLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMSSITYPSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVFYLFDVDLEDEKSTGGALSLVAPRKIPEKILAPTRNESSWIQQQVDRAAAFDWQFIPGPPFLIGAMMVLFALLINSTLPHTPTPSKYFRRSSPSLSRQSSDTARLLSSSDSSPHC</sequence>
</entry>
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    <accession>A0A0K3ARR2</accession>
    <name>A0A0K3ARR2_CAEEL</name>
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        <recommendedName>
            <fullName evidence="6">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
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    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:58456"/>
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        </cofactor>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-0106">Calcium</keyword>
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    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0807">Transducer</keyword>
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            <begin position="711"/>
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            <begin position="1022"/>
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            <end position="947"/>
        </location>
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            <end position="996"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="10">
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            <end position="1034"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1038"/>
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        <location>
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            <position position="403"/>
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        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
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        <ligand>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
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        <source>
            <dbReference type="PROSITE" id="PS50008"/>
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        <source>
            <dbReference type="EMBL" id="CTQ86721.1"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
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        <source>
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    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARR2"/>
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    </evidence>
    <sequence length="1265" mass="144173" checksum="3D0788A0F752A154" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARR4</accession>
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        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="179"/>
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        <source>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CTQ86542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y43H11AL.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARR4"/>
        </source>
    </evidence>
    <sequence length="223" mass="25035" checksum="F1D7E456CC0CECC5" modified="2015-11-11" version="1">MLGAILTNQQPIQKIIGVYYIIQDLVLWTQYGYYLKIYNRPTTSSARSNTIVVPVLALASVGSFFVFESALPPVGDHRVKRSFLESLNHQEGLPLEGILKMWPIFTSYTDMLGYIIGSMAAVCYFGGRIPQIIKNYRHSSCEGLSLTMFYIIVAANFTYGISVLLATTSWLYLLRHLPWLAGSLGCCCFDAVIISQYYLYRPKTPLAEDTERAGLLNSQDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARR7</accession>
    <name>A0A0K3ARR7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">egl-8</name>
        <name evidence="17" type="ORF">B0348.4</name>
        <name evidence="15" type="ORF">CELE_B0348.4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="8"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368557.1">
        <property type="nucleotide sequence ID" value="NM_001380581.2"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0K3ARR7"/>
    <dbReference type="GeneID" id="178537"/>
    <dbReference type="AGR" id="WB:WBGene00001177"/>
    <dbReference type="CTD" id="178537"/>
    <dbReference type="WormBase" id="B0348.4q">
        <property type="protein sequence ID" value="CE50603"/>
        <property type="gene ID" value="WBGene00001177"/>
        <property type="gene designation" value="egl-8"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001177">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARR7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16200">
        <property type="entry name" value="EFh_PI-PLCbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1230.10:FF:000006">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000052">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000047">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="14">
        <location>
            <begin position="730"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="849"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="604"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1044"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1123"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1046"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1123"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1140"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1164"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CTQ86726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="B0348.4q"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARR7"/>
        </source>
    </evidence>
    <sequence length="1391" mass="156065" checksum="58568946B4C9AD1F" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARR9</accession>
    <name>A0A0K3ARR9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">sym-2</name>
        <name evidence="5" type="ORF">CELE_ZK1067.6</name>
        <name evidence="7" type="ORF">ZK1067.6</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300608.1">
        <property type="nucleotide sequence ID" value="NM_001313679.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARR9"/>
    <dbReference type="SMR" id="A0A0K3ARR9"/>
    <dbReference type="GeneID" id="174461"/>
    <dbReference type="AGR" id="WB:WBGene00006367"/>
    <dbReference type="CTD" id="174461"/>
    <dbReference type="WormBase" id="ZK1067.6b">
        <property type="protein sequence ID" value="CE03707"/>
        <property type="gene ID" value="WBGene00006367"/>
        <property type="gene designation" value="sym-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431068at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006367">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARR9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="RRM2_ESRPs_Fusilli"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
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            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CTQ86547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="ZK1067.6b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARR9"/>
        </source>
    </evidence>
    <sequence length="346" mass="38436" checksum="DA6B3CCDB4106079" modified="2015-11-11" version="1">MEFVSANAIIVRMRGLPYDCTDAQIRTFFEPLKLTDKILFITRTDGRPTGDAFVQFETEEDAQQGLLKHRQVIGQRYIELFKSTAAEVQQVVKRCNLINSSPAVANAVEAPEEKKKDCVRLRGLPYEATVQHIVTFLGDFATMVKFQGVHMVYNNQGHPSGEAFIQMINEQAASACAAGVHNNFMSVGKKKRYIEVFQASAEELNLHHLVGQQHQVPPPAPLGFMGQLPPQAPQPQQFWSSYPSPPISPIVPGQVTQLIIYGIHMSIGVPELVANFTTPEHTVDNVLFTRWPTHLCPGEAILTLRNRGAPPPQTSPLSQISQLSAPNFAAYSHHPQNFPLQPILME</sequence>
</entry>
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    <accession>A0A0K3ART4</accession>
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        <submittedName>
            <fullName evidence="1">Methyltransf_21 domain-containing protein</fullName>
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    <gene>
        <name evidence="1 3" type="ORF">BE0003N10.6</name>
        <name evidence="1" type="ORF">CELE_BE0003N10.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299863.1">
        <property type="nucleotide sequence ID" value="NM_001312934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ART4"/>
    <dbReference type="GeneID" id="25502968"/>
    <dbReference type="AGR" id="WB:WBGene00255598"/>
    <dbReference type="CTD" id="25502968"/>
    <dbReference type="WormBase" id="BE0003N10.6e">
        <property type="protein sequence ID" value="CE50225"/>
        <property type="gene ID" value="WBGene00255598"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863008at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00255598">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ART4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CTQ86563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="BE0003N10.6e"/>
        </source>
    </evidence>
    <sequence length="28" mass="3321" checksum="EDA96A9A4251ACF0" modified="2015-11-11" version="1">MHTGGGVHRMFFLNVQDKECLAKYFNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ART9</accession>
    <name>A0A0K3ART9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sterile alpha and TIR motif-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">tir-1</name>
        <name evidence="8" type="ORF">CELE_F13B10.1</name>
        <name evidence="10" type="ORF">F13B10.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299868.1">
        <property type="nucleotide sequence ID" value="NM_001312939.3"/>
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    <dbReference type="GeneID" id="175502"/>
    <dbReference type="AGR" id="WB:WBGene00006575"/>
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    <dbReference type="WormBase" id="F13B10.1h">
        <property type="protein sequence ID" value="CE50820"/>
        <property type="gene ID" value="WBGene00006575"/>
        <property type="gene designation" value="tir-1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001940">
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    </dbReference>
    <dbReference type="Bgee" id="WBGene00006575">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of MyD88-independent toll-like receptor signaling pathway"/>
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    </dbReference>
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        <property type="term" value="P:response to axon injury"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SAM_SARM1-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sterile alpha and TIR motif-containing protein tir-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000023">
        <property type="entry name" value="Sterile alpha and TIR motif-containing protein tir-1"/>
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    </dbReference>
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        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TIR_dom"/>
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    <dbReference type="InterPro" id="IPR035897">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="6">
        <location>
            <begin position="122"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="F13B10.1h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ART9"/>
        </source>
    </evidence>
    <sequence length="346" mass="39310" checksum="F720E13205946EF1" modified="2015-11-11" version="1">MVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAADYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHPDDVEVAMLSKQIDVFISYRRSTGNQLASLIKVLLQLRGYRVFIDVDKLYAGKFDSSLLKNIQAAKHFILVLTPNSLDRLLNDDNCEDWVHKELKCAFEHQKNIIPIFDTAFEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGELNRTTPTTKEMPSISRKTTQQRWQTTNTVSRTGPSRSIGGPRMEPPTPTFFSVTPTGSQERATSTRRKIQPSASTTSDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARW5</accession>
    <name>A0A0K3ARW5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">pqn-80</name>
        <name evidence="2" type="ORF">CELE_Y111B2A.14</name>
        <name evidence="4" type="ORF">Y111B2A.14</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        <location>
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            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="69"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CTQ86659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="T02D1.6b"/>
        </source>
    </evidence>
    <sequence length="425" mass="47754" checksum="FBD70B1F78AB9D08" modified="2015-11-11" version="1">MPASDSSRVMASINATMCQEQPDGILYCPNHTGGPVWVRNVYPPIQELQPKVLIVVVVFVLCFIVGVCGNSSIITIIRGVVEDRRKRMKRHGDNAILYIGALCVCDFVMSLSLPPAILDSVIGFWIFGTTMCKVHHVFGSVGRIASTFLITAMSFDRYVAVCYPHHHRLRSRTFVISTIACLSSIAFVLLLPMLTYASAKEMVLHELKAHESANITRVRVFKCSDMMPGPIFYWFTSTTFILGYVVPLILIVYFNLKLINKLYAHKRVLPRSAIPVRRVVVYTVLIAAVYFVCWTPYWFSVLYAIIMSLLGKPTTNSEWVLFAIYCVHLLPYFGSSSNWILYGLLNTQLQMKNDIGDDGQSIMTTNGVQDLPRRSTSRLICDAGATSSRSIPTNNTPLWQNDSTLTRGNSDTSMVFYQDTEQTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS26</accession>
    <name>A0A0K3AS26_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ion transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">ocr-2</name>
        <name evidence="10" type="ORF">CELE_T09A12.3</name>
        <name evidence="12" type="ORF">T09A12.3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CTQ86664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299963.1">
        <property type="nucleotide sequence ID" value="NM_001313034.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS26"/>
    <dbReference type="GeneID" id="188314"/>
    <dbReference type="KEGG" id="cel:CELE_T09A12.3"/>
    <dbReference type="AGR" id="WB:WBGene00003839"/>
    <dbReference type="CTD" id="188314"/>
    <dbReference type="WormBase" id="T09A12.3b">
        <property type="protein sequence ID" value="CE50531"/>
        <property type="gene ID" value="WBGene00003839"/>
        <property type="gene designation" value="ocr-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="533508at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003839">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS26">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF30">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="9">
        <location>
            <begin position="93"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CTQ86664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="T09A12.3b"/>
        </source>
    </evidence>
    <sequence length="476" mass="54892" checksum="109EA7B0FA43118B" modified="2015-11-11" version="1">MIVSFTAFTLYYICFVTAFTLRPIGFSTEMLTEGWINRYSEPFPGRYGKNSTLQQVKPVINATSRGLVEWSEPLSQCHLRNYWDPDIPFANSYIRLVFELFVVIGICVQVFLDFRDIKRIGRKKWWNVLTAFPAKITFKLTYFLVLAMIPTRLACDLSPVLLVVDNVLITVTMIFTTVHYLYYCRVIRFVGPFVLMVYTIIATDIFRFMLIYGIFLMGFSQSFSLIFLSCEREANVIKKLITDQSEASEGSDNKFNLTRQISAYDTAIVKNAEVFENVMQSPIEAFVRTFILTIGEFTVLYRNLALCPANTMVWIGKVVFILFELFVSIMQFNMLIAMMTRTYETIFQTQLEYKRQRAQVILMLELSLSPKERHQYLLKYSRPTGTNKKTRSLVVSKKSAFSRDSKKGQKVLEEKMKKMIEEKKAVLKRKMKDMEIKEGIRPVTGYSRTPRPHTQYMNRGAGGGANGVQNGNGAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS30</accession>
    <name>A0A0K3AS30_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S54 rhomboid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">rom-4</name>
        <name evidence="10" type="ORF">CELE_Y116A8C.16</name>
        <name evidence="12" type="ORF">Y116A8C.16</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CTQ86669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368545.1">
        <property type="nucleotide sequence ID" value="NM_001380565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS30"/>
    <dbReference type="SMR" id="A0A0K3AS30"/>
    <dbReference type="GeneID" id="3565076"/>
    <dbReference type="AGR" id="WB:WBGene00004403"/>
    <dbReference type="CTD" id="3565076"/>
    <dbReference type="WormBase" id="Y116A8C.16f">
        <property type="protein sequence ID" value="CE50657"/>
        <property type="gene ID" value="WBGene00004403"/>
        <property type="gene designation" value="rom-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004403">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS30">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000025">
        <property type="entry name" value="Putative rhomboid family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF3">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="329"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CTQ86669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y116A8C.16f"/>
        </source>
    </evidence>
    <sequence length="606" mass="68760" checksum="24E3A896831D4F24" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS33</accession>
    <name>A0A0K3AS33_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y116A8C.25</name>
        <name evidence="3 5" type="ORF">Y116A8C.25</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CTQ86674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS33"/>
    <dbReference type="SMR" id="A0A0K3AS33"/>
    <dbReference type="AGR" id="WB:WBGene00013802"/>
    <dbReference type="WormBase" id="Y116A8C.25f">
        <property type="protein sequence ID" value="CE50582"/>
        <property type="gene ID" value="WBGene00013802"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013802">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS33">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CTQ86674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y116A8C.25f"/>
        </source>
    </evidence>
    <sequence length="187" mass="21388" checksum="28CADE045C71A77C" modified="2015-11-11" version="1">MHAKNGEQLAQNARRTRFVSVNSGMSDISKSEEGEQIGTENFGFHVTTCCGRLGQENDWTETWEEFFIRHRLKPQIDRLIETHNDRQLFELSEILYTKTAKLLKCRENVLPSLVHGDLWGGNWSMTTADGAPEPIIFDPSSSYSDPEFEFGIMKMFEIQKADKPVSGIQISWQIDSDRRQSISELGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS51</accession>
    <name>A0A0K3AS51_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y2H9A.4</name>
        <name evidence="3 5" type="ORF">Y2H9A.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300000.1">
        <property type="nucleotide sequence ID" value="NM_001313071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS51"/>
    <dbReference type="SMR" id="A0A0K3AS51"/>
    <dbReference type="GeneID" id="189352"/>
    <dbReference type="AGR" id="WB:WBGene00012381"/>
    <dbReference type="CTD" id="189352"/>
    <dbReference type="WormBase" id="Y2H9A.4d">
        <property type="protein sequence ID" value="CE50324"/>
        <property type="gene ID" value="WBGene00012381"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877453at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012381">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS51">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007883">
        <property type="entry name" value="DUF713"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21566">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251-LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21566:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05218">
        <property type="entry name" value="DUF713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CTQ86699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y2H9A.4d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AS51"/>
        </source>
    </evidence>
    <sequence length="597" mass="69093" checksum="D86806437C23BF87" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS53</accession>
    <name>A0A0K3AS53_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein containing ALS2cr12 (ALS2CR12) signature</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F53H2.1</name>
        <name evidence="2 4" type="ORF">F53H2.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300117.1">
        <property type="nucleotide sequence ID" value="NM_001313188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS53"/>
    <dbReference type="SMR" id="A0A0K3AS53"/>
    <dbReference type="GeneID" id="186191"/>
    <dbReference type="KEGG" id="cel:CELE_F53H2.1"/>
    <dbReference type="AGR" id="WB:WBGene00010004"/>
    <dbReference type="CTD" id="186191"/>
    <dbReference type="WormBase" id="F53H2.1b">
        <property type="protein sequence ID" value="CE50728"/>
        <property type="gene ID" value="WBGene00010004"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5889702at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010004">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS53">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007883">
        <property type="entry name" value="DUF713"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21566:SF2">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21566">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251-LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05218">
        <property type="entry name" value="DUF713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F53H2.1b"/>
        </source>
    </evidence>
    <sequence length="756" mass="87922" checksum="99F01A271B224CC4" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS85</accession>
    <name>A0A0K3AS85_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">egl-8</name>
        <name evidence="15" type="ORF">B0348.4</name>
        <name evidence="13" type="ORF">CELE_B0348.4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Sulson J.E."/>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="6"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300030.1">
        <property type="nucleotide sequence ID" value="NM_001313101.3"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0K3AS85"/>
    <dbReference type="GeneID" id="178537"/>
    <dbReference type="AGR" id="WB:WBGene00001177"/>
    <dbReference type="CTD" id="178537"/>
    <dbReference type="WormBase" id="B0348.4t">
        <property type="protein sequence ID" value="CE50660"/>
        <property type="gene ID" value="WBGene00001177"/>
        <property type="gene designation" value="egl-8"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001177">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS85">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="match status" value="6"/>
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        <location>
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            <end position="545"/>
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        <location>
            <begin position="710"/>
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        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PeptideAtlas" id="A0A131MDF3"/>
        </source>
    </evidence>
    <sequence length="749" mass="83645" checksum="CFA9429B7D477011" modified="2016-05-11" version="1"> </sequence>
</entry>
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            <taxon>Metazoa</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="VVC12365.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="K09F5.1b"/>
        </source>
    </evidence>
    <sequence length="358" mass="41030" checksum="D7DBE77133729B98" modified="2019-11-13" version="1">MGTELKIDEKKFDRYIEYLTAGYKLTKALKWFSMQTAHMDLVQKENLLNYANHYVQSNMEEVRKYSMRILINHDAQRVEDIINTNAEESQKYDAIELVEDSRKNKLQDFVSGDLPADLNRMLPNYDSFQSLPILSGGGVVNSSSHCQQNNDLEDMLKRKRTNCMIYAGKAKSQPTKILVQTIDKSFEVANVNSSLVFGNNRFEKLDSKLNNLSFYELRFHIDSNPQFANTADELFKKFVFKEFLNKLRGKPVNKKWRVYLEELKDEENKKAIKLNMLTKRIGGKMEKSVVKKAIQLETPVSSAAKRNFGNLGAPNPRVGKIKSVTPPIFKISKHTGSLKSLKKATPLLAKCKKMCGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5S9MPT0</accession>
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    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
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    <dbReference type="AGR" id="WB:WBGene00022473"/>
    <dbReference type="CTD" id="172054"/>
    <dbReference type="WormBase" id="Y119C1B.8h">
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        <property type="gene ID" value="WBGene00022473"/>
        <property type="gene designation" value="bet-1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A5S9MPT0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05497">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043508">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 3" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Bromo" evidence="6">
        <location>
            <begin position="56"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="6">
        <location>
            <begin position="277"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="7">
        <location>
            <begin position="516"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
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        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="712"/>
            <end position="740"/>
        </location>
    </feature>
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        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA0059117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y119C1B.8h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="A0A5S9MPT0"/>
        </source>
    </evidence>
    <sequence length="857" mass="94445" checksum="7F10DAB212BCFEF1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-03-20" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A2VA01</accession>
    <name>A2VA01_CAEEL</name>
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        <submittedName>
            <fullName evidence="2">Uma2 domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CELE_Y62H9A.15</name>
        <name evidence="2 4" type="ORF">Y62H9A.15</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAM33499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257179.1">
        <property type="nucleotide sequence ID" value="NM_001270250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A2VA01"/>
    <dbReference type="SMR" id="A2VA01"/>
    <dbReference type="GeneID" id="6418872"/>
    <dbReference type="UCSC" id="Y62H9A.15">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00045252"/>
    <dbReference type="CTD" id="6418872"/>
    <dbReference type="WormBase" id="Y62H9A.15a">
        <property type="protein sequence ID" value="CE40727"/>
        <property type="gene ID" value="WBGene00045252"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152760_0_0_1"/>
    <dbReference type="OrthoDB" id="5845637at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00045252">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A2VA01">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAM33499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y62H9A.15a"/>
        </source>
    </evidence>
    <sequence length="107" mass="12283" checksum="7D7100BC49BE75B3" modified="2007-03-20" version="1">MSQNDEAFLMSSEVEDGLVVEEELDENEPHPSTSTNILNQDDVESEMNRILSTPWYELNQDQTDVIQRLVSISENNQIDHADLRNSIENALIELATIRWRNAQIAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT13</accession>
    <name>D3YT13_CAEEL</name>
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        <submittedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">hum-4</name>
        <name evidence="12" type="ORF">CELE_F46C3.3</name>
        <name evidence="14" type="ORF">F46C3.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
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        <property type="protein sequence ID" value="CBK19448.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257158.1">
        <property type="nucleotide sequence ID" value="NM_001270229.4"/>
    </dbReference>
    <dbReference type="SMR" id="D3YT13"/>
    <dbReference type="PeptideAtlas" id="D3YT13"/>
    <dbReference type="GeneID" id="181335"/>
    <dbReference type="KEGG" id="cel:CELE_F46C3.3"/>
    <dbReference type="AGR" id="WB:WBGene00002037"/>
    <dbReference type="CTD" id="181335"/>
    <dbReference type="WormBase" id="F46C3.3d">
        <property type="protein sequence ID" value="CE45025"/>
        <property type="gene ID" value="WBGene00002037"/>
        <property type="gene designation" value="hum-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007045_0_0_1"/>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
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        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT13">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.530:FF:000012">
        <property type="entry name" value="Heavy chain, Unconventional Myosin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059004">
        <property type="entry name" value="MYO15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26570">
        <property type="entry name" value="MYO15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="768"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="11">
        <location>
            <begin position="898"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBK19448.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F46C3.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT13"/>
        </source>
    </evidence>
    <sequence length="1375" mass="158291" checksum="043833E9227B5CDA" modified="2010-07-13" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT14</accession>
    <name>D3YT14_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">hum-4</name>
        <name evidence="12" type="ORF">CELE_F46C3.3</name>
        <name evidence="14" type="ORF">F46C3.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CBK19449.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001257159.1">
        <property type="nucleotide sequence ID" value="NM_001270230.4"/>
    </dbReference>
    <dbReference type="SMR" id="D3YT14"/>
    <dbReference type="GeneID" id="181335"/>
    <dbReference type="AGR" id="WB:WBGene00002037"/>
    <dbReference type="CTD" id="181335"/>
    <dbReference type="WormBase" id="F46C3.3e">
        <property type="protein sequence ID" value="CE44960"/>
        <property type="gene ID" value="WBGene00002037"/>
        <property type="gene designation" value="hum-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007045_0_0_1"/>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002037">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT14">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.530:FF:000012">
        <property type="entry name" value="Heavy chain, Unconventional Myosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059004">
        <property type="entry name" value="MYO15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26570">
        <property type="entry name" value="MYO15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="679"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="11">
        <location>
            <begin position="809"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="10">
        <location>
            <begin position="970"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBK19449.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F46C3.3e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT14"/>
        </source>
    </evidence>
    <sequence length="1286" mass="148106" checksum="064407B95C603499" modified="2010-07-13" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT20</accession>
    <name>D3YT20_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DPH-type MB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">dph-3</name>
        <name evidence="4" type="ORF">CELE_K01H12.1</name>
        <name evidence="6" type="ORF">K01H12.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255420.1">
        <property type="nucleotide sequence ID" value="NM_001268491.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT20"/>
    <dbReference type="SMR" id="D3YT20"/>
    <dbReference type="GeneID" id="186854"/>
    <dbReference type="AGR" id="WB:WBGene00010484"/>
    <dbReference type="CTD" id="186854"/>
    <dbReference type="WormBase" id="K01H12.1b">
        <property type="protein sequence ID" value="CE44584"/>
        <property type="gene ID" value="WBGene00010484"/>
        <property type="gene designation" value="dph-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155991_3_0_1"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010484">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT20">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBK19458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="K01H12.1b"/>
        </source>
    </evidence>
    <sequence length="43" mass="4769" checksum="6309EC8652655D7B" modified="2010-04-20" version="1">MLEMGEDVAQCPSCSLLIRVIYDPEDFVKLETISTSKPIAEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT21</accession>
    <name>D3YT21_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DEgenerin Like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">del-2</name>
        <name evidence="1" type="ORF">CELE_F58G6.6</name>
        <name evidence="3" type="ORF">F58G6.6</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001367239.1">
        <property type="nucleotide sequence ID" value="NM_001380416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT21"/>
    <dbReference type="SMR" id="D3YT21"/>
    <dbReference type="GeneID" id="177796"/>
    <dbReference type="AGR" id="WB:WBGene00000953"/>
    <dbReference type="CTD" id="177796"/>
    <dbReference type="WormBase" id="F58G6.6b">
        <property type="protein sequence ID" value="CE44598"/>
        <property type="gene ID" value="WBGene00000953"/>
        <property type="gene designation" value="del-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034498_0_0_1"/>
    <dbReference type="OrthoDB" id="5831400at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000953">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT21">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F58G6.6b"/>
        </source>
    </evidence>
    <sequence length="451" mass="51508" checksum="7350BD9854967BA0" modified="2010-04-20" version="1">MKGHTDFDAAIEFLDNKMPSTLSLTDSDNSHSSNDITSSQAKEISYEDEMRLFIEKTGHLVTNVFADPFDSDERKSRTEMWVEASTENLAEGGTTSDDVPTEKELELDMENNDILAESVVGTGTGELNDEKDEETVPVGLIPPVARQSTEDSILSSNVTVNSLLKSKLTINLKEASEALSEIDIADVDRFWDYLYEKDDIQKFSDELIYPIKMEIPSTSSSERSIGIALSPIKLDFAGIHVQKTGKIEKHIKMNSNEEKDRELDEPLEITDQTVETRFFELETTKNLEKINRGTTTSEHGNILIKTTASQTPVSQEVVQLVNYEPINFTKAQSDRNFDEKENMIRAFSFKLSESFYKDLKILVVERDRAKEAMDILPAKTMKELSEECNYYQTRYRVRIEQNKEKLDRRIEEVWKKLLKMPIESQEVIDFISVAHSELLTLNARRNLPDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT22</accession>
    <name>D3YT22_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">mans-4</name>
        <name evidence="11" type="ORF">CELE_ZC410.3</name>
        <name evidence="13" type="ORF">ZC410.3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255362.1">
        <property type="nucleotide sequence ID" value="NM_001268433.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT22"/>
    <dbReference type="SMR" id="D3YT22"/>
    <dbReference type="PeptideAtlas" id="D3YT22"/>
    <dbReference type="GeneID" id="177726"/>
    <dbReference type="AGR" id="WB:WBGene00013881"/>
    <dbReference type="CTD" id="177726"/>
    <dbReference type="WormBase" id="ZC410.3b">
        <property type="protein sequence ID" value="CE44716"/>
        <property type="gene ID" value="WBGene00013881"/>
        <property type="gene designation" value="mans-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_3_3_1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013881">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT22">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000088">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF100">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003052913" description="alpha-1,2-Mannosidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBK19517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="ZC410.3b"/>
        </source>
    </evidence>
    <sequence length="514" mass="58615" checksum="D705A3BA4022C7F3" modified="2010-04-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT23</accession>
    <name>D3YT23_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">msa-1</name>
        <name evidence="2" type="ORF">CELE_ZC410.5</name>
        <name evidence="4" type="ORF">ZC410.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255363.1">
        <property type="nucleotide sequence ID" value="NM_001268434.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT23"/>
    <dbReference type="PeptideAtlas" id="D3YT23"/>
    <dbReference type="GeneID" id="177728"/>
    <dbReference type="AGR" id="WB:WBGene00013882"/>
    <dbReference type="CTD" id="177728"/>
    <dbReference type="WormBase" id="ZC410.5c">
        <property type="protein sequence ID" value="CE44715"/>
        <property type="gene ID" value="WBGene00013882"/>
        <property type="gene designation" value="msa-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136972_0_0_1"/>
    <dbReference type="OrthoDB" id="5813557at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013882">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT23">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="ZC410.5c"/>
        </source>
    </evidence>
    <sequence length="43" mass="4758" checksum="2A07B2387884938A" modified="2010-04-20" version="1">MVTEMFDKSGLNNVLKLVGMQNSAPSAFISAAFAPIFYMIFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT28</accession>
    <name>D3YT28_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F13H10.8</name>
        <name evidence="2 4" type="ORF">F13H10.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255527.1">
        <property type="nucleotide sequence ID" value="NM_001268598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT28"/>
    <dbReference type="GeneID" id="4363079"/>
    <dbReference type="AGR" id="WB:WBGene00044784"/>
    <dbReference type="CTD" id="4363079"/>
    <dbReference type="WormBase" id="F13H10.8b">
        <property type="protein sequence ID" value="CE44591"/>
        <property type="gene ID" value="WBGene00044784"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2673440_0_0_1"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044784">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT28">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F13H10.8b"/>
        </source>
    </evidence>
    <sequence length="30" mass="3703" checksum="F4AD4CD939DEF5DB" modified="2010-04-20" version="1">MLEPWEQRLFNWVIIFVLTTFISLITFFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT29</accession>
    <name>D3YT29_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">magi-1</name>
        <name evidence="3" type="ORF">CELE_K01A6.2</name>
        <name evidence="5" type="ORF">K01A6.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255581.1">
        <property type="nucleotide sequence ID" value="NM_001268652.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT29"/>
    <dbReference type="SMR" id="D3YT29"/>
    <dbReference type="GeneID" id="178107"/>
    <dbReference type="AGR" id="WB:WBGene00010444"/>
    <dbReference type="CTD" id="178107"/>
    <dbReference type="WormBase" id="K01A6.2e">
        <property type="protein sequence ID" value="CE44609"/>
        <property type="gene ID" value="WBGene00010444"/>
        <property type="gene designation" value="magi-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010444">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT29">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035254">
        <property type="term" value="F:glutamate receptor binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046959">
        <property type="term" value="P:habituation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
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        <property type="term" value="P:long-term memory"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
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        <property type="term" value="P:regulation of protein localization"/>
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        <property type="project" value="WormBase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PDZ4_MAGI-1_3-like"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="5"/>
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        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316:SF40">
        <property type="entry name" value="LD27118P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316">
        <property type="entry name" value="MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="199"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="312"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="494"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="598"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="745"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBK19457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="K01A6.2e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT29"/>
        </source>
    </evidence>
    <sequence length="829" mass="89621" checksum="51336566E9AEAA46" modified="2010-04-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT31</accession>
    <name>D3YT31_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_T12G3.2</name>
        <name evidence="3 5" type="ORF">T12G3.2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255611.1">
        <property type="nucleotide sequence ID" value="NM_001268682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT31"/>
    <dbReference type="GeneID" id="178140"/>
    <dbReference type="KEGG" id="cel:CELE_T12G3.2"/>
    <dbReference type="AGR" id="WB:WBGene00011738"/>
    <dbReference type="CTD" id="178140"/>
    <dbReference type="WormBase" id="T12G3.2e">
        <property type="protein sequence ID" value="CE44551"/>
        <property type="gene ID" value="WBGene00011738"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5827301at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011738">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT31">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09919">
        <property type="entry name" value="SH2_STAT_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBK19475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="T12G3.2e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT31"/>
        </source>
    </evidence>
    <sequence length="852" mass="97008" checksum="641FDB0A29BE8785" modified="2010-04-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT32</accession>
    <name>D3YT32_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme transporter hrg-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">hrg-6</name>
        <name evidence="1" type="ORF">CELE_F36H1.10</name>
        <name evidence="3" type="ORF">F36H1.10</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255530.1">
        <property type="nucleotide sequence ID" value="NM_001268601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT32"/>
    <dbReference type="GeneID" id="3565935"/>
    <dbReference type="AGR" id="WB:WBGene00009495"/>
    <dbReference type="CTD" id="3565935"/>
    <dbReference type="WormBase" id="F36H1.10c">
        <property type="protein sequence ID" value="CE44682"/>
        <property type="gene ID" value="WBGene00009495"/>
        <property type="gene designation" value="hrg-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3351582_0_0_1"/>
    <dbReference type="OrthoDB" id="5814279at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00009495">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT32">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="F36H1.10c"/>
        </source>
    </evidence>
    <sequence length="37" mass="4512" checksum="82E41BE7426E1D87" modified="2010-04-20" version="1">MLKWTWQNAFIARYYGKLLTKSIIHPEEPDDPSTWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT33</accession>
    <name>D3YT33_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">dur-1</name>
        <name evidence="2" type="ORF">CELE_F25H8.5</name>
        <name evidence="4" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255439.1">
        <property type="nucleotide sequence ID" value="NM_001268510.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT33"/>
    <dbReference type="PeptideAtlas" id="D3YT33"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5e">
        <property type="protein sequence ID" value="CE44571"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019234_0_0_1"/>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT33">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F25H8.5e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT33"/>
        </source>
    </evidence>
    <sequence length="381" mass="35649" checksum="AD9368F0208E180A" modified="2010-04-20" version="1">MYDAAAEGASNMAQSMHEAGKSTGDALSEGAEAGYDAVKDGGRWVGENVAHGAGKVADGAKYVKDSAAEGAKDAVHGAHEGMRMVGENVAHGAGKVADGAKAAGNYAVDSANTAGEAIVDGAKTVGQTASDGMRMIGENVAHGAGVVVEGAKSAGEQTVEGAKSGARWVGENVAHGAGKVADGAKSAGQSIADGAVAAKDAAVEGATTAGNKTVEGMRFVGENVAHGAGKVADGAKAAGDTVVEGGKAAAEKTESGIAFVGQKIAEGAGAVAGGAKAAGGAVVDGVAAAGGAVVGGAKAVGSGIADGAKFVGENVAYGAGAVAGGAKAAGGAVVDGAAAAGGAVVDGAKAVGGFVSDTFSSARDETGEALKTAGSKVKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT34</accession>
    <name>D3YT34_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dauer Up-Regulated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">dur-1</name>
        <name evidence="2" type="ORF">CELE_F25H8.5</name>
        <name evidence="4" type="ORF">F25H8.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255443.1">
        <property type="nucleotide sequence ID" value="NM_001268514.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT34"/>
    <dbReference type="PeptideAtlas" id="D3YT34"/>
    <dbReference type="GeneID" id="177846"/>
    <dbReference type="AGR" id="WB:WBGene00001113"/>
    <dbReference type="CTD" id="177846"/>
    <dbReference type="WormBase" id="F25H8.5f">
        <property type="protein sequence ID" value="CE44641"/>
        <property type="gene ID" value="WBGene00001113"/>
        <property type="gene designation" value="dur-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019234_0_0_1"/>
    <dbReference type="OrthoDB" id="5877852at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001113">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT34">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F25H8.5f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT34"/>
        </source>
    </evidence>
    <sequence length="300" mass="27646" checksum="D59CFEB9CDC8EB99" modified="2010-04-20" version="1">MRMVGENVAHGAGKVADGAKAAGNYAVDSANTAGEAIVDGAKTVGQTASDGMRMIGENVAHGAGVVVEGAKSAGEQTVEGAKSGARWVGENVAHGAGKVADGAKSAGQSIADGAVAAKDAAVEGATTAGNKTVEGMRFVGENVAHGAGKVADGAKAAGDTVVEGGKAAAEKTESGIAFVGQKIAEGAGAVAGGAKAAGGAVVDGVAAAGGAVVGGAKAVGSGIADGAKFVGENVAYGAGAVAGGAKAAGGAVVDGAAAAGGAVVDGAKAVGGFVSDTFSSARDETGEALKTAGSKVKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT35</accession>
    <name>D3YT35_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_ZK593.2</name>
        <name evidence="1 3" type="ORF">ZK593.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255519.1">
        <property type="nucleotide sequence ID" value="NM_001268590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT35"/>
    <dbReference type="PeptideAtlas" id="D3YT35"/>
    <dbReference type="GeneID" id="191354"/>
    <dbReference type="AGR" id="WB:WBGene00014002"/>
    <dbReference type="CTD" id="191354"/>
    <dbReference type="WormBase" id="ZK593.2b">
        <property type="protein sequence ID" value="CE44566"/>
        <property type="gene ID" value="WBGene00014002"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1723977_0_0_1"/>
    <dbReference type="OrthoDB" id="5818853at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014002">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT35">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="ZK593.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT35"/>
        </source>
    </evidence>
    <sequence length="123" mass="13982" checksum="AB7DE1A2ED736870" modified="2010-04-20" version="1">MYTAARLTDEYKHILDGKIKLAESHIFTDDVTVDDCGKGGNFDYLSDKLDSLIPTLSEINVSVKFAYPVPFTNNTIEFSIDEILTLHDGNVQQGEKAFFARTDEKDDKYRIYDIRAVPCYSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT36</accession>
    <name>D3YT36_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pyruvate kinase</fullName>
            <ecNumber evidence="17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">pyk-2</name>
        <name evidence="20" type="ORF">CELE_ZK593.1</name>
        <name evidence="22" type="ORF">ZK593.1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:18159"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="17"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255516.1">
        <property type="nucleotide sequence ID" value="NM_001268587.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT36"/>
    <dbReference type="SMR" id="D3YT36"/>
    <dbReference type="PeptideAtlas" id="D3YT36"/>
    <dbReference type="GeneID" id="177984"/>
    <dbReference type="AGR" id="WB:WBGene00014001"/>
    <dbReference type="CTD" id="177984"/>
    <dbReference type="WormBase" id="ZK593.1b">
        <property type="protein sequence ID" value="CE06622"/>
        <property type="gene ID" value="WBGene00014001"/>
        <property type="gene designation" value="pyk-2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014001">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT36">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14 20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="32"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="393"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CBK19520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="ZK593.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT36"/>
        </source>
    </evidence>
    <sequence length="513" mass="55841" checksum="CDCF1F241305FCAD" modified="2010-04-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT37</accession>
    <name>D3YT37_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pyruvate kinase</fullName>
            <ecNumber evidence="17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 22" type="primary">pyk-2</name>
        <name evidence="20" type="ORF">CELE_ZK593.1</name>
        <name evidence="22" type="ORF">ZK593.1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:18159"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="17"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255517.1">
        <property type="nucleotide sequence ID" value="NM_001268588.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT37"/>
    <dbReference type="SMR" id="D3YT37"/>
    <dbReference type="PeptideAtlas" id="D3YT37"/>
    <dbReference type="GeneID" id="177984"/>
    <dbReference type="AGR" id="WB:WBGene00014001"/>
    <dbReference type="CTD" id="177984"/>
    <dbReference type="WormBase" id="ZK593.1c">
        <property type="protein sequence ID" value="CE44718"/>
        <property type="gene ID" value="WBGene00014001"/>
        <property type="gene designation" value="pyk-2"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_1"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00014001">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT37">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007005"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="23" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14 20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="341"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CBK19521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WormBase" id="ZK593.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT37"/>
        </source>
    </evidence>
    <sequence length="461" mass="50234" checksum="ED8A4E7012D7D865" modified="2010-04-20" version="1">MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNMKEVQLENGKSVRVSTDPSMEFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVYYPKGRIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIVVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT38</accession>
    <name>D3YT38_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F19B6.1</name>
        <name evidence="2 4" type="ORF">F19B6.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255641.1">
        <property type="nucleotide sequence ID" value="NM_001268712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT38"/>
    <dbReference type="SMR" id="D3YT38"/>
    <dbReference type="PeptideAtlas" id="D3YT38"/>
    <dbReference type="GeneID" id="178181"/>
    <dbReference type="KEGG" id="cel:CELE_F19B6.1"/>
    <dbReference type="AGR" id="WB:WBGene00008948"/>
    <dbReference type="CTD" id="178181"/>
    <dbReference type="WormBase" id="F19B6.1c">
        <property type="protein sequence ID" value="CE44568"/>
        <property type="gene ID" value="WBGene00008948"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_0_1_1"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008948">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT38">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000124">
        <property type="entry name" value="Uridine cytidine kinase I, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBK19440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F19B6.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT38"/>
        </source>
    </evidence>
    <sequence length="145" mass="16278" checksum="4B0030D338272FC6" modified="2010-04-20" version="1">MRAGECMETALRSIVKDCVIGKILIQTNETTFDPELHYIRLPPHITRYKVIIMDATVTTGSAAMMAIRVLLDHDVKEEDIFVASLLMGQQGAHALAYAFPKVKLITTAMDHQMTENCYLIPGMGNFGDRYYGTGLEQDMDEPFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT44</accession>
    <name>D3YT44_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cation-transporting ATPase 13A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">catp-6</name>
        <name evidence="15" type="ORF">CELE_W08D2.5</name>
        <name evidence="17" type="ORF">W08D2.5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255432.1">
        <property type="nucleotide sequence ID" value="NM_001268503.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT44"/>
    <dbReference type="SMR" id="D3YT44"/>
    <dbReference type="PeptideAtlas" id="D3YT44"/>
    <dbReference type="GeneID" id="177822"/>
    <dbReference type="AGR" id="WB:WBGene00012341"/>
    <dbReference type="CTD" id="177822"/>
    <dbReference type="WormBase" id="W08D2.5b">
        <property type="protein sequence ID" value="CE44722"/>
        <property type="gene ID" value="WBGene00012341"/>
        <property type="gene designation" value="catp-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_0_4_1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012341">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT44">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000130">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="759"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="869"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBK19479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WormBase" id="W08D2.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT44"/>
        </source>
    </evidence>
    <sequence length="893" mass="99183" checksum="BB84418AF690B15F" modified="2010-04-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT45</accession>
    <name>D3YT45_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C39E9.8</name>
        <name evidence="1" type="ORF">CELE_C39E9.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255696.1">
        <property type="nucleotide sequence ID" value="NM_001268767.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT45"/>
    <dbReference type="SMR" id="D3YT45"/>
    <dbReference type="PeptideAtlas" id="D3YT45"/>
    <dbReference type="GeneID" id="178255"/>
    <dbReference type="AGR" id="WB:WBGene00008032"/>
    <dbReference type="CTD" id="178255"/>
    <dbReference type="WormBase" id="C39E9.8d">
        <property type="protein sequence ID" value="CE44665"/>
        <property type="gene ID" value="WBGene00008032"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5774418at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008032">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT45">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401:SF6">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401">
        <property type="entry name" value="PROTEIN CBG12388-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C39E9.8d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT45"/>
        </source>
    </evidence>
    <sequence length="187" mass="21539" checksum="F103CE77E63B496F" modified="2010-04-20" version="1">MKLQAKDCTVPCFQKFSSITSRPNDLKKCFDEKDNILEDFLTCFENRVEACVNDQHGPQIQKTDIRGIFKVTEKSIATQTNTFQTMIKPIKHILDATGDFALCVKDCFLEKNKSGFCFDRKGCQPLVAETKARQSFRACTKKMHWKREAGELCECSVQAGVDSRELRQYCAMFKLMRRRAPMRKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT46</accession>
    <name>D3YT46_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C39E9.8</name>
        <name evidence="1" type="ORF">CELE_C39E9.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255697.1">
        <property type="nucleotide sequence ID" value="NM_001268768.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT46"/>
    <dbReference type="SMR" id="D3YT46"/>
    <dbReference type="PeptideAtlas" id="D3YT46"/>
    <dbReference type="GeneID" id="178255"/>
    <dbReference type="AGR" id="WB:WBGene00008032"/>
    <dbReference type="CTD" id="178255"/>
    <dbReference type="WormBase" id="C39E9.8e">
        <property type="protein sequence ID" value="CE44688"/>
        <property type="gene ID" value="WBGene00008032"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098768_0_0_1"/>
    <dbReference type="OrthoDB" id="5774418at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008032">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT46">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401:SF6">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401">
        <property type="entry name" value="PROTEIN CBG12388-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C39E9.8e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT46"/>
        </source>
    </evidence>
    <sequence length="185" mass="21310" checksum="297BE02CAE31D52E" modified="2010-04-20" version="1">MKLQAKDCTVPCFQKFSSITSRPNDLKKCFDEKDNILEDFLTCFENRVEACVNDQHGPQIQKTDIRGIFKVTEKSIATQTNTFQTMIKPIKHILDATGDFALCVKDCFLEKNKSGFCFDRKGCQPLVAETKARQSFRACTKKMHWKREAGELCECSVQAGVEELRQYCAMFKLMRRRAPMRKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT47</accession>
    <name>D3YT47_CAEEL</name>
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        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C39E9.8</name>
        <name evidence="1" type="ORF">CELE_C39E9.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255699.1">
        <property type="nucleotide sequence ID" value="NM_001268770.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT47"/>
    <dbReference type="SMR" id="D3YT47"/>
    <dbReference type="IntAct" id="D3YT47">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="D3YT47"/>
    <dbReference type="GeneID" id="178255"/>
    <dbReference type="AGR" id="WB:WBGene00008032"/>
    <dbReference type="CTD" id="178255"/>
    <dbReference type="WormBase" id="C39E9.8f">
        <property type="protein sequence ID" value="CE44572"/>
        <property type="gene ID" value="WBGene00008032"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098768_0_0_1"/>
    <dbReference type="OrthoDB" id="5774418at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008032">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT47">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C39E9.8f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT47"/>
        </source>
    </evidence>
    <sequence length="43" mass="5130" checksum="54AA5F25C8B2DC88" modified="2010-04-20" version="1">MHWKREAGELCECSVQAGVEELRQYCAMFKLMRRRAPMRKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT48</accession>
    <name>D3YT48_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 3" type="ORF">C39E9.8</name>
        <name evidence="1" type="ORF">CELE_C39E9.8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255698.1">
        <property type="nucleotide sequence ID" value="NM_001268769.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT48"/>
    <dbReference type="PeptideAtlas" id="D3YT48"/>
    <dbReference type="GeneID" id="178255"/>
    <dbReference type="AGR" id="WB:WBGene00008032"/>
    <dbReference type="CTD" id="178255"/>
    <dbReference type="WormBase" id="C39E9.8g">
        <property type="protein sequence ID" value="CE44642"/>
        <property type="gene ID" value="WBGene00008032"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3242671_0_0_1"/>
    <dbReference type="OrthoDB" id="5774418at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00008032">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT48">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="C39E9.8g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT48"/>
        </source>
    </evidence>
    <sequence length="45" mass="5359" checksum="FDD813A659322FEC" modified="2010-04-20" version="1">MHWKREAGELCECSVQAGVDSRELRQYCAMFKLMRRRAPMRKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT49</accession>
    <name>D3YT49_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_R102.11</name>
        <name evidence="1 3" type="ORF">R102.11</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255505.1">
        <property type="nucleotide sequence ID" value="NM_001268576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT49"/>
    <dbReference type="GeneID" id="7040123"/>
    <dbReference type="AGR" id="WB:WBGene00077714"/>
    <dbReference type="CTD" id="7040123"/>
    <dbReference type="WormBase" id="R102.11b">
        <property type="protein sequence ID" value="CE44681"/>
        <property type="gene ID" value="WBGene00077714"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164960_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00077714">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT49">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBK19466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="R102.11b"/>
        </source>
    </evidence>
    <sequence length="88" mass="8921" checksum="7FE35BF1A3338282" modified="2010-04-20" version="1">MGCSCLPPPPSPVCMPPPPPPCPMPIPCPPPPPACSCPPPVTMYQPCMVPQYVPRCSGGCGGCGGGYGGGYGGGCGRRRRAINNQTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>F1LIL5</accession>
    <name>F1LIL5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="ORF">C30B5.6</name>
        <name evidence="3" type="ORF">CELE_C30B5.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CCD66132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001254110.1">
        <property type="nucleotide sequence ID" value="NM_001267181.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F1LIL5"/>
    <dbReference type="PeptideAtlas" id="F1LIL5"/>
    <dbReference type="GeneID" id="183042"/>
    <dbReference type="AGR" id="WB:WBGene00016247"/>
    <dbReference type="CTD" id="183042"/>
    <dbReference type="WormBase" id="C30B5.6a">
        <property type="protein sequence ID" value="CE45836"/>
        <property type="gene ID" value="WBGene00016247"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1099351_0_0_1"/>
    <dbReference type="OrthoDB" id="5818640at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016247">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F1LIL5">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003266888" evidence="2">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD66132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C30B5.6a"/>
        </source>
    </evidence>
    <sequence length="253" mass="27856" checksum="F324AA7E860A3BA0" modified="2011-05-03" version="1">MSVSTAFLLLLWSSIAGSLPLAPASPDFKADFSKLLKEAHQTDLMPVVEEDELQSLRHNGFQEQLHHLRQKTVGRNSATITEEMARIRNSIEDISEFSLDSNEVDEAINDITVPYGTKMKKSSKFAELSEIHNTDSSNKALPPFAFSEDQQESVDVVEKVEAVPPTTTTTKLTTLPSTTQSTTTRTTTQPSTIVSTRQKYVNVDGDIYVPGKTVISVSSTPIVDRTGTTTPVSIEISTTTLPPMTEIFTTKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>F1LIM5</accession>
    <name>F1LIM5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZZ-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">sqst-1</name>
        <name evidence="9" type="ORF">CELE_T12G3.1</name>
        <name evidence="11" type="ORF">T12G3.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBZ42130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255609.1">
        <property type="nucleotide sequence ID" value="NM_001268680.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F1LIM5"/>
    <dbReference type="SMR" id="F1LIM5"/>
    <dbReference type="PeptideAtlas" id="F1LIM5"/>
    <dbReference type="GeneID" id="178139"/>
    <dbReference type="AGR" id="WB:WBGene00011737"/>
    <dbReference type="CTD" id="178139"/>
    <dbReference type="WormBase" id="T12G3.1b">
        <property type="protein sequence ID" value="CE45860"/>
        <property type="gene ID" value="WBGene00011737"/>
        <property type="gene designation" value="sqst-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400222_0_0_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="8">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="582"/>
            <end position="621"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="350"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ42130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="T12G3.1b"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PeptideAtlas" id="F1LIM5"/>
        </source>
    </evidence>
    <sequence length="621" mass="68415" checksum="80FE16B796205181" modified="2011-05-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>F1LIM6</accession>
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        </recommendedName>
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        <name evidence="7 9" type="primary">fkb-1</name>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
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            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="BX284604">
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    </dbReference>
    <dbReference type="RefSeq" id="NP_001255532.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="F1LIM6"/>
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    <dbReference type="PeptideAtlas" id="F1LIM6"/>
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    <dbReference type="AGR" id="WB:WBGene00001426"/>
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    <dbReference type="WormBase" id="F36H1.1b">
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        <property type="gene ID" value="WBGene00001426"/>
        <property type="gene designation" value="fkb-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_8_2_1"/>
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    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F1LIM6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
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        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ42124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="F36H1.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="F1LIM6"/>
        </source>
    </evidence>
    <sequence length="90" mass="10080" checksum="307E9D3F75221137" modified="2011-05-03" version="1">MHYTGTLLDGTEFDSSRTRNEEFTFTLGQGNVIKGWDQGLLNMCVGERRILTIPPHLGYGERGAPPKIPGNSVLKFDVELMKIDRDGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>F1LIM7</accession>
    <name>F1LIM7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Calpain catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">clp-9</name>
        <name evidence="13" type="ORF">CELE_T11A5.6</name>
        <name evidence="15" type="ORF">T11A5.6</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CBZ42128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001370282.1">
        <property type="nucleotide sequence ID" value="NM_001383377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F1LIM7"/>
    <dbReference type="SMR" id="F1LIM7"/>
    <dbReference type="MEROPS" id="C02.A02"/>
    <dbReference type="GeneID" id="266916"/>
    <dbReference type="AGR" id="WB:WBGene00011705"/>
    <dbReference type="CTD" id="266916"/>
    <dbReference type="WormBase" id="T11A5.6c">
        <property type="protein sequence ID" value="CE06412"/>
        <property type="gene ID" value="WBGene00011705"/>
        <property type="gene designation" value="clp-9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003001_1_0_1"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00011705">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="F1LIM7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000010">
        <property type="entry name" value="Calpain 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF382">
        <property type="entry name" value="CALPAIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="12">
        <location>
            <begin position="34"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
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        </location>
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        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBZ42128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="T11A5.6c"/>
        </source>
    </evidence>
    <sequence length="616" mass="69616" checksum="32E3C4E35810C066" modified="2011-05-03" version="1"> </sequence>
</entry>
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    <accession>G5EGT0</accession>
    <name>G5EGT0_CAEEL</name>
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        <submittedName>
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        <name evidence="10 12" type="primary">mel-11</name>
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    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRARP family.</text>
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        <property type="protein sequence ID" value="CAD57685.1"/>
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    <dbReference type="CTD" id="174484"/>
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        <property type="protein sequence ID" value="CE32566"/>
        <property type="gene ID" value="WBGene00003196"/>
        <property type="gene designation" value="mel-11"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19014at2759"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003196">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="G5EGT0">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005856">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
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        <property type="project" value="WormBase"/>
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        <property type="project" value="WormBase"/>
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        <property type="entry name" value="Myosin binding subunit, isoform P"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
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    <feature type="repeat" description="ANK" evidence="6">
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    <feature type="repeat" description="ANK" evidence="6">
        <location>
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            <end position="278"/>
        </location>
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            <end position="1018"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="821"/>
            <end position="898"/>
        </location>
    </feature>
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        <location>
            <begin position="904"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="969"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="479"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="570"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="830"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="860"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD57685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="C06C3.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PeptideAtlas" id="G5EGT0"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111049" checksum="FDABE33ED2F92589" modified="2011-12-14" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-07-24" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>H2KYZ5-2</accession>
    <name>TBCEL_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform b of Tubulin-specific chaperone cofactor E-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">coel-1</name>
        <name evidence="4" type="ORF">C52B9.3</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS A AND B)</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="e1003804" last="e1003804">
            <title>Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis.</title>
            <authorList>
                <person name="Frederic M.Y."/>
                <person name="Lundin V.F."/>
                <person name="Whiteside M.D."/>
                <person name="Cueva J.G."/>
                <person name="Tu D.K."/>
                <person name="Kang S.Y."/>
                <person name="Singh H."/>
                <person name="Baillie D.L."/>
                <person name="Hutter H."/>
                <person name="Goodman M.B."/>
                <person name="Brinkman F.S."/>
                <person name="Leroux M.R."/>
            </authorList>
            <dbReference type="PubMed" id="24098140"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003804"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2014" name="Cell Rep." volume="6" first="93" last="103">
            <title>Loss of MEC-17 leads to microtubule instability and axonal degeneration.</title>
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                <person name="Neumann B."/>
                <person name="Hilliard M.A."/>
            </authorList>
            <dbReference type="PubMed" id="24373971"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2013.12.004"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H2KYZ5-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_062364"/>
        </isoform>
        <isoform>
            <id>H2KYZ5-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_741765.1">
        <property type="nucleotide sequence ID" value="NM_171947.7"/>
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        <property type="protein sequence ID" value="CE30912"/>
        <property type="gene ID" value="WBGene00016866"/>
        <property type="gene designation" value="coel-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
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    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0000305" key="2">
        <source>
            <dbReference type="PubMed" id="24098140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="C52B9.3a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="C52B9.3b"/>
        </source>
    </evidence>
    <sequence length="418" mass="47978" checksum="32A88B1B7C940150" modified="2012-03-21" version="1">MEEGCSTLVRSLEQKYLDDDEDIVQDIIFTGFTGCSPCKMASQRALELLVLNNMNIDTIGDSEKLATLASHVSEADLGWNQISKWSDIACILKNLPHLRVLNIGHNPLNPVIDHELPVSTLHTIILNVLPKVTELHMSDNQFNDDDDCDEPISTTVRTVHLNRCGFLKWSSVMNVVKRFPNVCSVFVCENPLKDVTHCKHFEQLPFWNFLNLAKTSIDSWDSLDQLNRMTSISDLRVPNIPLLDALTNEERLHLIIGRLHHLRVLNGSKISSEQREQSERFFIRYYQEQKEKPLQYKTLIDKHGNLEKLVTIDLTPKKEAVVKILCEEKEVNQEITISLEPTVLDFMKILDPKVGVKFTRMKLFLLREDGRTDDFSSSDYNMPLHYFKIEDGDSFLVQEKIIVTRRRRPPSSTSSSSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-10-25" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H9G301-2</accession>
    <name>MDT28_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform a of Coiled-coil domain-containing protein mdt-28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">mdt-28</name>
        <name evidence="5" type="ORF">F28F8.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2017" name="PeerJ" volume="5" first="E3390" last="E3390">
            <title>The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development.</title>
            <authorList>
                <person name="Kostrouchova M."/>
                <person name="Kostrouch D."/>
                <person name="Chughtai A.A."/>
                <person name="Kassak F."/>
                <person name="Novotny J.P."/>
                <person name="Kostrouchova V."/>
                <person name="Benda A."/>
                <person name="Krause M.W."/>
                <person name="Saudek V."/>
                <person name="Kostrouchova M."/>
                <person name="Kostrouch Z."/>
            </authorList>
            <dbReference type="PubMed" id="28603670"/>
            <dbReference type="DOI" id="10.7717/peerj.3390"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MDT-6 AND MDT-30</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>H9G301-2</id>
            <name evidence="4">a</name>
            <sequence type="described" ref="VSP_059205"/>
        </isoform>
        <isoform>
            <id>H9G301-1</id>
            <name evidence="5">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001256673.1">
        <property type="nucleotide sequence ID" value="NM_001269744.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F28F8.5a">
        <property type="protein sequence ID" value="CE09759"/>
        <property type="gene ID" value="WBGene00009223"/>
        <property type="gene designation" value="mdt-28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="28603670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F28F8.5a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F28F8.5b"/>
        </source>
    </evidence>
    <sequence length="200" mass="22305" checksum="8A875BF3D00A4099" modified="2012-05-16" version="1">MFEELDAEDGGEEQEMPMNEFGGGGEDIDDILGDAPDLPDDEYSNSVPQGAADGSIENDERRMRNDGAGSTNEDDEEPIEPTYLGDAIDSLMMHWCQLLTNVSVKAPVPPPSTLNHVKEVAEVCSKHFRDASVDVNNEFTRLGVQWEMEQPYSQYAIEEENLDEAIERQETIIAAAREMLNSRIQIYNEAHPNAGKHFTT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>O16000-2</accession>
    <name>STX1A_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform a of Syntaxin-1A homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Uncoordinated protein 64</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">unc-64</name>
        <name evidence="7" type="ORF">F56A8.7</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1991" name="Neurosci. Lett." volume="128" first="243" last="244">
            <title>Additional genes which result in an elevation of acetylcholine levels by mutations in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hosono R."/>
                <person name="Kamiya Y."/>
            </authorList>
            <dbReference type="PubMed" id="1945043"/>
            <dbReference type="DOI" id="10.1016/0304-3940(91)90270-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="Neurochem. Int." volume="29" first="553" last="563">
            <title>Expression, purification and characterization of recombinant C. Elegans UNC-18.</title>
            <authorList>
                <person name="Ogawa H."/>
                <person name="Hayashi N."/>
                <person name="Hori I."/>
                <person name="Kobayashi T."/>
                <person name="Hosono R."/>
            </authorList>
            <dbReference type="PubMed" id="8939465"/>
            <dbReference type="DOI" id="10.1016/0197-0186(95)00012-7"/>
        </citation>
        <scope>INTERACTION WITH UNC-18</scope>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="2192" last="2198">
            <title>Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin.</title>
            <authorList>
                <person name="Ogawa H."/>
                <person name="Harada S."/>
                <person name="Sassa T."/>
                <person name="Yamamoto H."/>
                <person name="Hosono R."/>
            </authorList>
            <dbReference type="PubMed" id="9442061"/>
            <dbReference type="DOI" id="10.1074/jbc.273.4.2192"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH UNC-18</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="2 3" key="4">
        <citation type="journal article" date="1998" name="Mol. Biol. Cell" volume="9" first="1235" last="1252">
            <title>The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin.</title>
            <authorList>
                <person name="Saifee O."/>
                <person name="Wei L."/>
                <person name="Nonet M.L."/>
            </authorList>
            <dbReference type="PubMed" id="9614171"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 265-291 (ISOFORM A)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Bristol N2</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1999" name="J. Neurosci." volume="19" first="4772" last="4777">
            <title>Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13.</title>
            <authorList>
                <person name="Sassa T."/>
                <person name="Harada S."/>
                <person name="Ogawa H."/>
                <person name="Rand J.B."/>
                <person name="Maruyama I.N."/>
                <person name="Hosono R."/>
            </authorList>
            <dbReference type="PubMed" id="10366611"/>
            <dbReference type="DOI" id="10.1523/jneurosci.19-12-04772.1999"/>
        </citation>
        <scope>INTERACTION WITH UNC-18</scope>
    </reference>
    <reference evidence="2" key="7">
        <citation type="journal article" date="1999" name="Proc. Natl. Acad. Sci. U.S.A." volume="96" first="7394" last="7397">
            <title>Neurosecretory control of aging in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Ailion M."/>
                <person name="Inoue T."/>
                <person name="Weaver C.I."/>
                <person name="Holdcraft R.W."/>
                <person name="Thomas J.H."/>
            </authorList>
            <dbReference type="PubMed" id="10377425"/>
            <dbReference type="DOI" id="10.1073/pnas.96.13.7394"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ALA-248</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2003" name="Nat. Neurosci." volume="6" first="1023" last="1030">
            <title>Defects in synaptic vesicle docking in unc-18 mutants.</title>
            <authorList>
                <person name="Weimer R.M."/>
                <person name="Richmond J.E."/>
                <person name="Davis W.S."/>
                <person name="Hadwiger G."/>
                <person name="Nonet M.L."/>
                <person name="Jorgensen E.M."/>
            </authorList>
            <dbReference type="PubMed" id="12973353"/>
            <dbReference type="DOI" id="10.1038/nn1118"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2007" name="Nat. Neurosci." volume="10" first="1300" last="1307">
            <title>Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Van Buskirk C."/>
                <person name="Sternberg P.W."/>
            </authorList>
            <dbReference type="PubMed" id="17891142"/>
            <dbReference type="DOI" id="10.1038/nn1981"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ALA-248</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="3836" last="3846">
            <title>UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.</title>
            <authorList>
                <person name="McEwen J.M."/>
                <person name="Kaplan J.M."/>
            </authorList>
            <dbReference type="PubMed" id="18596236"/>
            <dbReference type="DOI" id="10.1091/mbc.e08-02-0160"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>INTERACTION WITH UNC-18</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF LEU-9</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2009" name="Biochem. J." volume="418" first="73" last="80">
            <title>Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Johnson J.R."/>
                <person name="Ferdek P."/>
                <person name="Lian L.Y."/>
                <person name="Barclay J.W."/>
                <person name="Burgoyne R.D."/>
                <person name="Morgan A."/>
            </authorList>
            <dbReference type="PubMed" id="19032153"/>
            <dbReference type="DOI" id="10.1042/bj20081956"/>
        </citation>
        <scope>INTERACTION WITH UNC-18</scope>
        <scope>MUTAGENESIS OF 1-MET--ASP-21; LEU-9 AND ILE-234</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2010" name="Front. Synaptic Neurosci." volume="2" first="141" last="141">
            <title>Differential Regulation of Synaptic Vesicle Tethering and Docking by UNC-18 and TOM-1.</title>
            <authorList>
                <person name="Gracheva E.O."/>
                <person name="Maryon E.B."/>
                <person name="Berthelot-Grosjean M."/>
                <person name="Richmond J.E."/>
            </authorList>
            <dbReference type="PubMed" id="21423527"/>
            <dbReference type="DOI" id="10.3389/fnsyn.2010.00141"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>INTERACTION WITH UNC-18</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>O16000-2</id>
            <name evidence="6">a</name>
            <name evidence="1">syn1a</name>
            <sequence type="described" ref="VSP_052630"/>
        </isoform>
        <isoform>
            <id>O16000-1</id>
            <name evidence="7">b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001022614.1">
        <property type="nucleotide sequence ID" value="NM_001027443.6"/>
    </dbReference>
    <dbReference type="WormBase" id="F56A8.7a">
        <property type="protein sequence ID" value="CE16127"/>
        <property type="gene ID" value="WBGene00006798"/>
        <property type="gene designation" value="unc-64"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="9442061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="EMBL" id="AAD10538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="BAA23584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="CAB05747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="WormBase" id="F56A8.7a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="WormBase" id="F56A8.7b"/>
        </source>
    </evidence>
    <sequence length="291" mass="33314" checksum="A23E47EA538B6E69" modified="1998-01-01" version="1">MTKDRLSALKAAQSEDEQDDDMHMDTGNAQYMEEFFEQVEEIRGSVDIIANNVEEVKKKHSAILSNPVNDQKTKEELDELMAVIKRAANKVRGKLKLIENAIDHDEQGAGNADLRIRKTQHSTLSRRFVEVMTDYNKTQTDYRERCKGRIQRQLDIAGKQVGDEDLEEMIESGNPGVFTQGIITDTQQAKQTLADIEARHNDIMKLESSIRELHDMFMDMAMLVESQGEMVDRIEYNVEHAKEFVDRAVADTKKAVQYQSKARRKKIIILIVVTILIGFVSLWLIQYIPGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2026-01-28" version="189" xmlns="https://uniprot.org/uniprot">
    <accession>P30429-1</accession>
    <name>CED4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Cell death protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ced-4</name>
        <name type="ORF">C35D10.9</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1986" name="Cell" volume="44" first="817" last="829">
            <title>Genetic control of programmed cell death in the nematode C. elegans.</title>
            <authorList>
                <person name="Ellis H.M."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="3955651"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="Development" volume="116" first="309" last="320">
            <title>The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death.</title>
            <authorList>
                <person name="Yuan J."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="1286611"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1996" name="Cell" volume="86" first="201" last="208">
            <title>An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor.</title>
            <authorList>
                <person name="Shaham S."/>
                <person name="Horvitz H.R."/>
            </authorList>
            <dbReference type="PubMed" id="8706125"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(00)80092-6"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1997" name="Science" volume="275" first="1126" last="1129">
            <title>Interaction and regulation of subcellular localization of CED-4 by CED-9.</title>
            <authorList>
                <person name="Wu D."/>
                <person name="Wallen H.D."/>
                <person name="Nunez G."/>
            </authorList>
            <dbReference type="PubMed" id="9027313"/>
            <dbReference type="DOI" id="10.1126/science.275.5303.1126"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INTERACTION WITH CED-9</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1999" name="Development" volume="126" first="1011" last="1022">
            <title>Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.</title>
            <authorList>
                <person name="Gumienny T.L."/>
                <person name="Lambie E."/>
                <person name="Hartwieg E."/>
                <person name="Horvitz H.R."/>
                <person name="Hengartner M.O."/>
            </authorList>
            <dbReference type="PubMed" id="9927601"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1999" name="Development" volume="126" first="2021" last="2031">
            <title>C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death.</title>
            <authorList>
                <person name="Wu D."/>
                <person name="Chen P.J."/>
                <person name="Chen S."/>
                <person name="Hu Y."/>
                <person name="Nunez G."/>
                <person name="Ellis R.E."/>
            </authorList>
            <dbReference type="PubMed" id="10101135"/>
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        <scope>INTERACTION WITH MAC-1</scope>
        <scope>MUTAGENESIS OF ILE-258</scope>
    </reference>
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        <scope>FUNCTION</scope>
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        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
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        <scope>MUTAGENESIS OF 80-GLN--CYS-549</scope>
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            <dbReference type="PubMed" id="15383288"/>
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        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CED-9</scope>
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        <scope>X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF ISOFORM A IN COMPLEX WITH CED-9; ATP AND MAGNESIUM</scope>
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        <scope>MUTAGENESIS OF VAL-230; ARG-233; MET-234 AND 250-ASP-ASP-251</scope>
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        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS) OF ISOFORM A IN COMPLEX WITH CED-3 MUTANT ALA-358</scope>
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            <id>P30429-2</id>
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    <reference key="1">
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        <scope>ALTERNATIVE SPLICING</scope>
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            <strain>Bristol N2</strain>
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                <person name="Raices M."/>
                <person name="Verdun R.E."/>
                <person name="Compton S.A."/>
                <person name="Haggblom C.I."/>
                <person name="Griffith J.D."/>
                <person name="Dillin A."/>
                <person name="Karlseder J."/>
            </authorList>
            <dbReference type="PubMed" id="18329362"/>
            <dbReference type="DOI" id="10.1016/j.cell.2007.12.039"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="7805" last="7810">
            <title>Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths.</title>
            <authorList>
                <person name="Cheng C."/>
                <person name="Shtessel L."/>
                <person name="Brady M.M."/>
                <person name="Ahmed S."/>
            </authorList>
            <dbReference type="PubMed" id="22547822"/>
            <dbReference type="DOI" id="10.1073/pnas.1119191109"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="G3 (Bethesda)" volume="3" first="305" last="313">
            <title>Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways.</title>
            <authorList>
                <person name="Shtessel L."/>
                <person name="Lowden M.R."/>
                <person name="Cheng C."/>
                <person name="Simon M."/>
                <person name="Wang K."/>
                <person name="Ahmed S."/>
            </authorList>
            <dbReference type="PubMed" id="23390606"/>
            <dbReference type="DOI" id="10.1534/g3.112.004440"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="J. Cell Biol." volume="203" first="727" last="735">
            <title>The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery.</title>
            <authorList>
                <person name="Ferreira H.C."/>
                <person name="Towbin B.D."/>
                <person name="Jegou T."/>
                <person name="Gasser S.M."/>
            </authorList>
            <dbReference type="PubMed" id="24297748"/>
            <dbReference type="DOI" id="10.1083/jcb.201307181"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P42001-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_060413"/>
        </isoform>
        <isoform>
            <id>P42001-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P42001-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_060412"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001348725.1">
        <property type="nucleotide sequence ID" value="NM_001361732.2"/>
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        <property type="protein sequence ID" value="CE52643"/>
        <property type="gene ID" value="WBGene00015105"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
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    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="18329362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="B0280.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="B0280.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="B0280.10c"/>
        </source>
    </evidence>
    <sequence length="153" mass="17611" checksum="F9273756265EE7D0" modified="2019-11-13" version="3">MESFHAAFRIRISIETYGVFLTIPLELIKTELDICEDWDSESNIVEEEEKVTRFKKNIQEKVRDASIVHIKGISSLLLIIMLNINSISLVNNITENKRILLQKSNVPSSLQLKILITPFVIVVVRFFGITWIYSGSSCIEEVLNLIDNCSRRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>P42001-3</accession>
    <name>POT1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform c of Protection of telomeres homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pot-1</name>
        <name evidence="1" type="synonym">CeOB2</name>
        <name evidence="2" type="ORF">B0280.10</name>
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    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Cell" volume="132" first="745" last="757">
            <title>C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins.</title>
            <authorList>
                <person name="Raices M."/>
                <person name="Verdun R.E."/>
                <person name="Compton S.A."/>
                <person name="Haggblom C.I."/>
                <person name="Griffith J.D."/>
                <person name="Dillin A."/>
                <person name="Karlseder J."/>
            </authorList>
            <dbReference type="PubMed" id="18329362"/>
            <dbReference type="DOI" id="10.1016/j.cell.2007.12.039"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="7805" last="7810">
            <title>Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths.</title>
            <authorList>
                <person name="Cheng C."/>
                <person name="Shtessel L."/>
                <person name="Brady M.M."/>
                <person name="Ahmed S."/>
            </authorList>
            <dbReference type="PubMed" id="22547822"/>
            <dbReference type="DOI" id="10.1073/pnas.1119191109"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="G3 (Bethesda)" volume="3" first="305" last="313">
            <title>Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways.</title>
            <authorList>
                <person name="Shtessel L."/>
                <person name="Lowden M.R."/>
                <person name="Cheng C."/>
                <person name="Simon M."/>
                <person name="Wang K."/>
                <person name="Ahmed S."/>
            </authorList>
            <dbReference type="PubMed" id="23390606"/>
            <dbReference type="DOI" id="10.1534/g3.112.004440"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="J. Cell Biol." volume="203" first="727" last="735">
            <title>The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery.</title>
            <authorList>
                <person name="Ferreira H.C."/>
                <person name="Towbin B.D."/>
                <person name="Jegou T."/>
                <person name="Gasser S.M."/>
            </authorList>
            <dbReference type="PubMed" id="24297748"/>
            <dbReference type="DOI" id="10.1083/jcb.201307181"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P42001-3</id>
            <name evidence="4">c</name>
            <sequence type="described" ref="VSP_060413"/>
        </isoform>
        <isoform>
            <id>P42001-1</id>
            <name evidence="2">a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P42001-2</id>
            <name evidence="3">b</name>
            <sequence type="described" ref="VSP_060412"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001348726.1">
        <property type="nucleotide sequence ID" value="NM_001361730.1"/>
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    <dbReference type="WormBase" id="B0280.10c">
        <property type="protein sequence ID" value="CE52474"/>
        <property type="gene ID" value="WBGene00015105"/>
        <property type="gene designation" value="pot-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="18329362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="WormBase" id="B0280.10a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="B0280.10b"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="B0280.10c"/>
        </source>
    </evidence>
    <sequence length="379" mass="43929" checksum="B69749F8CDDD7FBA" modified="2019-11-13" version="3">MQYTYQHIQDLVPGPTPQNFYGKIIFIKKKINQIVVLIKLRQVVRVHRCKIQSILNSKEGIAQIGLFGCHLIAWSQSGKVDNPVIISSRSWTKSDEDSERLQTLRKLGKSRRKSGRKTSVDTMANKLIERREAMFADTFIKSLFNKIALSRKEHLSRNARELFYHRPGDIVETQNLLEIDDSWFNDENSEQFVQYVLNCTTCHVEYNHVEYAQNNIPTNCRFCQEAMESFHAAFRIRISIETYGVFLTIPLELIKTELDICEDWDSESNIVEEEEKVTRFKKNIQEKVRDASIVHIKGISSLLLIIMLNINSISLVNNITENKRILLQKSNVPSSLQLKILITPFVIVVVRFFGITWIYSGSSCIEEVLNLIDNCSRRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q02331-2</accession>
    <name>PLPL7_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform a of Patatin-like phospholipase domain-containing protein ZK370.4</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZK370.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Nature" volume="368" first="32" last="38">
            <title>2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.</title>
            <authorList>
                <person name="Wilson R."/>
                <person name="Ainscough R."/>
                <person name="Anderson K."/>
                <person name="Baynes C."/>
                <person name="Berks M."/>
                <person name="Bonfield J."/>
                <person name="Burton J."/>
                <person name="Connell M."/>
                <person name="Copsey T."/>
                <person name="Cooper J."/>
                <person name="Coulson A."/>
                <person name="Craxton M."/>
                <person name="Dear S."/>
                <person name="Du Z."/>
                <person name="Durbin R."/>
                <person name="Favello A."/>
                <person name="Fraser A."/>
                <person name="Fulton L."/>
                <person name="Gardner A."/>
                <person name="Green P."/>
                <person name="Hawkins T."/>
                <person name="Hillier L."/>
                <person name="Jier M."/>
                <person name="Johnston L."/>
                <person name="Jones M."/>
                <person name="Kershaw J."/>
                <person name="Kirsten J."/>
                <person name="Laisster N."/>
                <person name="Latreille P."/>
                <person name="Lightning J."/>
                <person name="Lloyd C."/>
                <person name="Mortimore B."/>
                <person name="O'Callaghan M."/>
                <person name="Parsons J."/>
                <person name="Percy C."/>
                <person name="Rifken L."/>
                <person name="Roopra A."/>
                <person name="Saunders D."/>
                <person name="Shownkeen R."/>
                <person name="Sims M."/>
                <person name="Smaldon N."/>
                <person name="Smith A."/>
                <person name="Smith M."/>
                <person name="Sonnhammer E."/>
                <person name="Staden R."/>
                <person name="Sulston J."/>
                <person name="Thierry-Mieg J."/>
                <person name="Thomas K."/>
                <person name="Vaudin M."/>
                <person name="Vaughan K."/>
                <person name="Waterston R."/>
                <person name="Watson A."/>
                <person name="Weinstock L."/>
                <person name="Wilkinson-Sproat J."/>
                <person name="Wohldman P."/>
            </authorList>
            <dbReference type="PubMed" id="7906398"/>
            <dbReference type="DOI" id="10.1038/368032a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q02331-1</id>
            <name evidence="4">b</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q02331-2</id>
            <name evidence="3">a</name>
            <sequence type="described" ref="VSP_006718"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="RefSeq" id="NP_498926.2">
        <property type="nucleotide sequence ID" value="NM_066525.3"/>
    </dbReference>
    <dbReference type="WormBase" id="ZK370.4a">
        <property type="protein sequence ID" value="CE34454"/>
        <property type="gene ID" value="WBGene00022718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A2AJ88"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="WormBase" id="ZK370.4a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="ZK370.4b"/>
        </source>
    </evidence>
    <sequence length="1342" mass="151081" checksum="34F63B3498AF605C" modified="2005-04-26" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q19338-2</accession>
    <name>MON2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform b of Monensin-resistant homolog 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mon-2</name>
        <name type="ORF">F11A10.4</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="J. Cell Sci." volume="118" first="4751" last="4764">
            <title>Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis.</title>
            <authorList>
                <person name="Efe J.A."/>
                <person name="Plattner F."/>
                <person name="Hulo N."/>
                <person name="Kressler D."/>
                <person name="Emr S.D."/>
                <person name="Deloche O."/>
            </authorList>
            <dbReference type="PubMed" id="16219684"/>
            <dbReference type="DOI" id="10.1242/jcs.02599"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="EMBO J." volume="27" first="1647" last="1657">
            <title>Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions.</title>
            <authorList>
                <person name="Kanamori T."/>
                <person name="Inoue T."/>
                <person name="Sakamoto T."/>
                <person name="Gengyo-Ando K."/>
                <person name="Tsujimoto M."/>
                <person name="Mitani S."/>
                <person name="Sawa H."/>
                <person name="Aoki J."/>
                <person name="Arai H."/>
            </authorList>
            <dbReference type="PubMed" id="18497747"/>
            <dbReference type="DOI" id="10.1038/emboj.2008.102"/>
        </citation>
        <scope>POSSIBLE FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q19338-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_043941"/>
        </isoform>
        <isoform>
            <id>Q19338-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001255623.1">
        <property type="nucleotide sequence ID" value="NM_001268694.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F11A10.4b">
        <property type="protein sequence ID" value="CE46488"/>
        <property type="gene ID" value="WBGene00008685"/>
        <property type="gene designation" value="mon-2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="1648" mass="181704" checksum="0783B742AF5FEABB" modified="1998-11-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HQK0</accession>
    <name>Q2HQK0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kelch domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_Y67H2A.2</name>
        <name evidence="1 3" type="ORF">Y67H2A.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041057.1">
        <property type="nucleotide sequence ID" value="NM_001047592.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HQK0"/>
    <dbReference type="SMR" id="Q2HQK0"/>
    <dbReference type="GeneID" id="178286"/>
    <dbReference type="UCSC" id="Y67H2A.2b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013461"/>
    <dbReference type="CTD" id="178286"/>
    <dbReference type="WormBase" id="Y67H2A.2b">
        <property type="protein sequence ID" value="CE39875"/>
        <property type="gene ID" value="WBGene00013461"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3108410_0_0_1"/>
    <dbReference type="OrthoDB" id="7676067at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013461">
        <property type="expression patterns" value="Expressed in adult organism and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2HQK0">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAJ76969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="Y67H2A.2b"/>
        </source>
    </evidence>
    <sequence length="51" mass="6013" checksum="991D4AB52E90B18F" modified="2006-03-21" version="1">MKAPSEMKKKKKSIVEMMILERKLIVKMMMMIEDDLAQLSNNFKLPGTTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HQK2</accession>
    <name>Q2HQK2_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">agt-1</name>
        <name evidence="13" type="ORF">CELE_Y62E10A.5</name>
        <name evidence="15" type="ORF">Y62E10A.5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041055.1">
        <property type="nucleotide sequence ID" value="NM_001047590.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HQK2"/>
    <dbReference type="SMR" id="Q2HQK2"/>
    <dbReference type="PeptideAtlas" id="Q2HQK2"/>
    <dbReference type="GeneID" id="190454"/>
    <dbReference type="UCSC" id="Y62E10A.5a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00000093"/>
    <dbReference type="CTD" id="190454"/>
    <dbReference type="WormBase" id="Y62E10A.5b">
        <property type="protein sequence ID" value="CE39872"/>
        <property type="gene ID" value="WBGene00000093"/>
        <property type="gene designation" value="agt-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_1"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000093">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2HQK2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000410">
        <property type="entry name" value="ADA regulatory protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="12">
        <location>
            <begin position="47"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAJ76952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="Y62E10A.5b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="Q2HQK2"/>
        </source>
    </evidence>
    <sequence length="133" mass="14420" checksum="1CF6C35563E55E01" modified="2006-03-21" version="1">MEELHDAYPTVNFIPGKPTQSSGIVQALNTLDSTIKVNAVHKGDTAFGMQVYSAIQKIPKGETRSYSDIAREIGNPSAVRAVASACARNNLAYIVPCHRVIGSTGNLSGYRWGIAKKRRLLQAEGAELRFSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HQK5</accession>
    <name>Q2HQK5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ariadne domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">ari-1.4</name>
        <name evidence="2" type="ORF">CELE_Y73F8A.34</name>
        <name evidence="4" type="ORF">Y73F8A.34</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041061.1">
        <property type="nucleotide sequence ID" value="NM_001047596.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HQK5"/>
    <dbReference type="SMR" id="Q2HQK5"/>
    <dbReference type="GeneID" id="178437"/>
    <dbReference type="UCSC" id="Y73F8A.34b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00013538"/>
    <dbReference type="CTD" id="178437"/>
    <dbReference type="WormBase" id="Y73F8A.34b">
        <property type="protein sequence ID" value="CE39877"/>
        <property type="gene ID" value="WBGene00013538"/>
        <property type="gene designation" value="ari-1.4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009823_4_2_1"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00013538">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2HQK5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ariadne" evidence="1">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ76955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y73F8A.34b"/>
        </source>
    </evidence>
    <sequence length="135" mass="15866" checksum="2AA819DF18BDA609" modified="2006-03-21" version="1">MAHQNSMKLEGKLYAKVEVKMDLMQALSMSWIEVQFLRRAVDALCECRRTLKYAYAFAYYLEANNMTTLFETNQSDLELATEQLSGMLEGDLEDNDLAELKRKVQDKYRYVELRRKKMLDHCAEGVELDSWVFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HQL3</accession>
    <name>Q2HQL3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">srv-15</name>
        <name evidence="7" type="ORF">CELE_Y105C5B.6</name>
        <name evidence="9" type="ORF">Y105C5B.6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041012.1">
        <property type="nucleotide sequence ID" value="NM_001047547.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HQL3"/>
    <dbReference type="SMR" id="Q2HQL3"/>
    <dbReference type="GeneID" id="190889"/>
    <dbReference type="UCSC" id="Y105C5B.6a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00005726"/>
    <dbReference type="CTD" id="190889"/>
    <dbReference type="WormBase" id="Y105C5B.6b">
        <property type="protein sequence ID" value="CE39808"/>
        <property type="gene ID" value="WBGene00005726"/>
        <property type="gene designation" value="srv-15"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065657_0_0_1"/>
    <dbReference type="OrthoDB" id="5798218at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00005726">
        <property type="expression patterns" value="Expressed in larva and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2HQL3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31748:SF11">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31748">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAJ76967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="Y105C5B.6b"/>
        </source>
    </evidence>
    <sequence length="213" mass="24515" checksum="984911B2A4B3B545" modified="2006-03-21" version="1">MCVSLMATNRVSAILFPNRHSRIWSSTRLRIAIAVQFLPGLLAGLATFFNETQLYRNTKNGLIPRFKSENFIAVLFVIAGGFLATVCIYLIIAYCYLIFMLRKSSNAIKNTQFHKSRAVIKKKEVKLFFMSSITVAIQISILCLVIVYATSLLNFPLDKFYLFYNAISDLYAGINPYLLWIFSDSLRKHIWHRIGWRRTWKIPTSSVVTVNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HQL4</accession>
    <name>Q2HQL4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamine synthetase</fullName>
            <ecNumber evidence="3 10">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">gln-3</name>
        <name evidence="13" type="ORF">CELE_Y105C5B.28</name>
        <name evidence="15" type="ORF">Y105C5B.28</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 10"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAB54376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041010.1">
        <property type="nucleotide sequence ID" value="NM_001047545.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HQL4"/>
    <dbReference type="SMR" id="Q2HQL4"/>
    <dbReference type="PeptideAtlas" id="Q2HQL4"/>
    <dbReference type="GeneID" id="178452"/>
    <dbReference type="UCSC" id="Y105C5B.28a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00001604"/>
    <dbReference type="CTD" id="178452"/>
    <dbReference type="WormBase" id="Y105C5B.28b">
        <property type="protein sequence ID" value="CE39807"/>
        <property type="gene ID" value="WBGene00001604"/>
        <property type="gene designation" value="gln-3"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_1"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001604">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2HQL4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="11">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="12">
        <location>
            <begin position="115"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAB54376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="Y105C5B.28b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="Q2HQL4"/>
        </source>
    </evidence>
    <sequence length="385" mass="43254" checksum="5EC46BD1DE91CEF4" modified="2006-03-21" version="1">MAQSLRSQFATDKQVLQKFLNLDQKGMYQALYIWIDGSGENIRAKTRTFDFEPTDPEKLPIWNFDGSSTGQAEGADSDVYLKPVAIYPDPFRQGKNKLVMCETYDNKKKPTATNYRQRCKEVMEKAADQHPWFGMEQEYTLLDIDGHPFGWPKNGFPGPQGPYYCGVGANKVYGRDIVEAHYRACLYAGIQISGTNAEVMPGQWEFQVGPCEGIQMGDQLWVARYLLQRVAEEFGVIASFDCKPIKGDWNGAGCHTNFSTDKMRNPGGIDEIMSAINKLSLVHPQHIAYYDPHGGKDNERRLTGLHETASIDKFSYGVASRASSIRIPRSTDDDGYGYFEDRRPSSNCDPYTVTGALVRTVCLEGAERKLSMMYVPSQAPNITKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HQL8</accession>
    <name>Q2HQL8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y43F8B.1</name>
        <name evidence="2 4" type="ORF">Y43F8B.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CAJ76975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041192.1">
        <property type="nucleotide sequence ID" value="NM_001047727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HQL8"/>
    <dbReference type="SMR" id="Q2HQL8"/>
    <dbReference type="PeptideAtlas" id="Q2HQL8"/>
    <dbReference type="GeneID" id="180279"/>
    <dbReference type="KEGG" id="cel:CELE_Y43F8B.1"/>
    <dbReference type="UCSC" id="Y43F8B.1a.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012812"/>
    <dbReference type="CTD" id="180279"/>
    <dbReference type="WormBase" id="Y43F8B.1c">
        <property type="protein sequence ID" value="CE39834"/>
        <property type="gene ID" value="WBGene00012812"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875553at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012812">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2HQL8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ76975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y43F8B.1c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q2HQL8"/>
        </source>
    </evidence>
    <sequence length="260" mass="29908" checksum="0FFD1D059E988452" modified="2006-03-21" version="1">MLAHQQAPFVNTADFNRKSHQPMDDACWQTQRRVPAEIQLPQVGKISIPELSEKEIQRTIVAQPASYHKVQWNEFPEEPKYEIGAVPKTKTQDWVPVNNEQNELQRSIYKPARMSAVWPPPQDELVKDGHSPLVVKANEDTAWIQQDQNGVLKQAVWGKTSRINRVWPPPENESTLSDFGPQHMPVVQWPPPEAEAHEREQVEVLQKHIPTKKMERQWPPPPPQYQVVESSGEIETRYNPAEVDQQQQAVNSLRMGHIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HQL9</accession>
    <name>Q2HQL9_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metalloendopeptidase</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">nas-6</name>
        <name evidence="10" type="ORF">4R79.1</name>
        <name evidence="8" type="ORF">CELE_4R79.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001040903.1">
        <property type="nucleotide sequence ID" value="NM_001047438.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HQL9"/>
    <dbReference type="SMR" id="Q2HQL9"/>
    <dbReference type="MEROPS" id="M12.A38"/>
    <dbReference type="GeneID" id="181796"/>
    <dbReference type="UCSC" id="4R79.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00003525"/>
    <dbReference type="CTD" id="181796"/>
    <dbReference type="WormBase" id="4R79.1b">
        <property type="protein sequence ID" value="CE39659"/>
        <property type="gene ID" value="WBGene00003525"/>
        <property type="gene designation" value="nas-6"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017286_0_0_1"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003525">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2HQL9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160094">
        <property type="term" value="P:nematode pharynx development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1940:FF:000002">
        <property type="entry name" value="PHAryngeal gland Toxin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF829">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="6">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAJ76926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="4R79.1b"/>
        </source>
    </evidence>
    <sequence length="180" mass="20611" checksum="97501ADE44B936B5" modified="2006-03-21" version="1">MHSVGFWHEHSRADRDDHIKINWDNILPGMKSQFDKISAVLQDLQGENYDYKSIMHYDSTAFSRNGRNTIETVENGFTQVIGTAMDLSPLDIVKINKLYSCKTKKKEKVKPATTEEPHQLIPQVVDKNSVDSGEKCVDHFADCPHFAQYCTRASFFFVMKSYCPFTCKHCPGDRKLKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HQM1</accession>
    <name>Q2HQM1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">lact-9</name>
        <name evidence="2" type="ORF">CELE_Y45F10D.11</name>
        <name evidence="4" type="ORF">Y45F10D.11</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041034.1">
        <property type="nucleotide sequence ID" value="NM_001047569.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HQM1"/>
    <dbReference type="SMR" id="Q2HQM1"/>
    <dbReference type="MEROPS" id="S12.A16"/>
    <dbReference type="PeptideAtlas" id="Q2HQM1"/>
    <dbReference type="GeneID" id="189927"/>
    <dbReference type="UCSC" id="Y45F10D.11a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012890"/>
    <dbReference type="CTD" id="189927"/>
    <dbReference type="WormBase" id="Y45F10D.11b">
        <property type="protein sequence ID" value="CE39840"/>
        <property type="gene ID" value="WBGene00012890"/>
        <property type="gene designation" value="lact-9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_6_0_1"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012890">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2HQM1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052794">
        <property type="entry name" value="Mito_Ser_Protease_LACTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46520">
        <property type="entry name" value="SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46520:SF1">
        <property type="entry name" value="SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ76948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y45F10D.11b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="Q2HQM1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18108" checksum="9BCDF4FCE45C1200" modified="2006-03-21" version="1">MRNTQLDTKEKIVPGRASYYQRNSKNILENCPEVDCSNKFAGGGIISNTTDLLIIANAILHSILSDSKNCLLQRETIRKFLEKQVPVDSKTSTGLGWFLVDGKDLKSIDGNISNSSFFYHTGAAVGASSVLLVNTSSGVCVAILCNLQNTTVLKLGRDIGDLFHGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-21" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q2HQM3</accession>
    <name>Q2HQM3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y38H8A.2</name>
        <name evidence="2 4" type="ORF">Y38H8A.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAJ76968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001041023.1">
        <property type="nucleotide sequence ID" value="NM_001047558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2HQM3"/>
    <dbReference type="GeneID" id="189703"/>
    <dbReference type="UCSC" id="Y38H8A.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012636"/>
    <dbReference type="CTD" id="189703"/>
    <dbReference type="WormBase" id="Y38H8A.2b">
        <property type="protein sequence ID" value="CE39825"/>
        <property type="gene ID" value="WBGene00012636"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1195818_0_0_1"/>
    <dbReference type="OrthoDB" id="5849472at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012636">
        <property type="expression patterns" value="Expressed in material anatomical entity and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q2HQM3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAJ76968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y38H8A.2b"/>
        </source>
    </evidence>
    <sequence length="87" mass="9688" checksum="63E6D331DF82E4EF" modified="2006-03-21" version="1">MLLNIDLKTNMILIHLPHSYNGADVNYFMKADDSLTNGPYEKDTKLSHLRHPKIAALSLEVTEKKTPSSETPSKENPKSPGPLDSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-08" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q3HKC3</accession>
    <name>Q3HKC3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RAB6-interacting golgin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CELE_K05B2.2</name>
        <name evidence="1 3" type="ORF">K05B2.2</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD72665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q3HKC3"/>
    <dbReference type="SMR" id="Q3HKC3"/>
    <dbReference type="PeptideAtlas" id="Q3HKC3"/>
    <dbReference type="UCSC" id="K05B2.2b.1">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00019403"/>
    <dbReference type="WormBase" id="K05B2.2b">
        <property type="protein sequence ID" value="CE39166"/>
        <property type="gene ID" value="WBGene00019403"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_872201_0_0_1"/>
    <dbReference type="OrthoDB" id="10051571at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019403">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q3HKC3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD72665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WormBase" id="K05B2.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PeptideAtlas" id="Q3HKC3"/>
        </source>
    </evidence>
    <sequence length="156" mass="17778" checksum="7F92579914723C8C" modified="2005-11-08" version="1">MSVMEKKNITMGAATIPQKDDFDCFKRADVKKLSETMNQQEVAEYLVQEEELRQLLKQQKNLRAILKPMIAANWPQQYQLELKKSHKLKASLAATKEAINKTRSDILRVEETEKDLMKKLAEFKKQDENGDENSEVLETSFDLGCSGTSTPLTVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-08" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q3HKC4</accession>
    <name>Q3HKC4_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">pcyt-1</name>
        <name evidence="13" type="ORF">CELE_F08C6.2</name>
        <name evidence="15" type="ORF">F08C6.2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="10"/>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CCD67345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001033540.1">
        <property type="nucleotide sequence ID" value="NM_001038451.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q3HKC4"/>
    <dbReference type="SMR" id="Q3HKC4"/>
    <dbReference type="GeneID" id="181021"/>
    <dbReference type="UCSC" id="F08C6.2a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00017241"/>
    <dbReference type="CTD" id="181021"/>
    <dbReference type="WormBase" id="F08C6.2b">
        <property type="protein sequence ID" value="CE39144"/>
        <property type="gene ID" value="WBGene00017241"/>
        <property type="gene designation" value="pcyt-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_4_1_1"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="BRENDA" id="2.7.7.15">
        <property type="organism ID" value="1045"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00753">
        <property type="reaction ID" value="UER00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00017241">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q3HKC4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="76"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="288"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD67345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WormBase" id="F08C6.2b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PeptideAtlas" id="Q3HKC4"/>
        </source>
    </evidence>
    <sequence length="354" mass="40727" checksum="65E2B7CE29C15B3C" modified="2005-11-08" version="1">MPQRKRTMDSPQEEDVEVKKKATEVEYVVRSLASDEPAPFSDEALAITTREAVDYSKKITLAMAEANEAGRPVRIYADGIYDLFHHGHANQLRQVKKMFPNVYLIVGVCGDRDTHKYKGRTVTSEEERYDGVRHCRYVDEVYREAPWFCTVEFLKNLKVDFIAHDAIPYVAPGEEDLYEKFRREGMFLETERTEGVSTSDVVCRIIRDYDKYVRRNLQRGYSPKELNVGFLAASKYQIQNKVDSLKSKGIELLSTWKSKSDDIIRDFIDTFHKDGGLNAFGGRLKGIMSMSRSPSPSPHEGSPTGIEHHLETQDEEEEEEALEEEKVVEQKIVEKKEVVKKRSSRNKAKTPLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-08" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q3LFN1</accession>
    <name>Q3LFN1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytosolic fatty-acid binding proteins domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lbp-9</name>
        <name evidence="5" type="ORF">CELE_Y40B10A.1</name>
        <name evidence="7" type="ORF">Y40B10A.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD70630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001033512.1">
        <property type="nucleotide sequence ID" value="NM_001038423.6"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q3LFN1"/>
    <dbReference type="SMR" id="Q3LFN1"/>
    <dbReference type="PeptideAtlas" id="Q3LFN1"/>
    <dbReference type="GeneID" id="178686"/>
    <dbReference type="UCSC" id="Y40B10A.1a">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00021486"/>
    <dbReference type="CTD" id="178686"/>
    <dbReference type="WormBase" id="Y40B10A.1b">
        <property type="protein sequence ID" value="CE39188"/>
        <property type="gene ID" value="WBGene00021486"/>
        <property type="gene designation" value="lbp-9"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113772_0_0_1"/>
    <dbReference type="OrthoDB" id="412780at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00021486">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q3LFN1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="4">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD70630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y40B10A.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="Q3LFN1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15263" checksum="81A4B6C189FAA6F1" modified="2005-11-08" version="1">MPIQTDLVGKWNFVSSENFDEYLKEVGVGWAIRTIATKTKPALEFAVNGDEWTMNSNSTFKNYTLKWKLGTASDEKTADGRDVSSVFSIENDHLVQIETGKGGGKDSRIERYIENGKLVIVCTCNGVKCTRVYEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q4R160</accession>
    <name>Q4R160_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BLVR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y54G2A.49</name>
        <name evidence="2 4" type="ORF">Y54G2A.49</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CCD83534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4R160"/>
    <dbReference type="SMR" id="Q4R160"/>
    <dbReference type="PeptideAtlas" id="Q4R160"/>
    <dbReference type="UCSC" id="Y54G2A.49">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00044492"/>
    <dbReference type="WormBase" id="Y54G2A.49a">
        <property type="protein sequence ID" value="CE38901"/>
        <property type="gene ID" value="WBGene00044492"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159522_0_0_1"/>
    <dbReference type="OrthoDB" id="5786233at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044492">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q4R160">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD83534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y54G2A.49a"/>
        </source>
    </evidence>
    <sequence length="103" mass="12071" checksum="DC6E6B12D91D943B" modified="2005-07-19" version="1">MDQVMKSKAMEAELLKLIEELSDSEKKTKMKKKKRRKTKKHRKRRKKKPSRGSRKRREEDGPVDAPRKIPLDEKEQQIAKGLKVASAAYPTLDENVKSDWDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-07-19" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q4R170</accession>
    <name>Q4R170_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">lgc-29</name>
        <name evidence="8" type="ORF">CELE_Y45G5AL.2</name>
        <name evidence="10" type="ORF">Y45G5AL.2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CCD74318.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001033513.2">
        <property type="nucleotide sequence ID" value="NM_001038424.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4R170"/>
    <dbReference type="SMR" id="Q4R170"/>
    <dbReference type="PaxDb" id="6239-Y45G5AL.2"/>
    <dbReference type="GeneID" id="3896858"/>
    <dbReference type="KEGG" id="cel:CELE_Y45G5AL.2"/>
    <dbReference type="UCSC" id="Y45G5AL.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00044528"/>
    <dbReference type="CTD" id="3896858"/>
    <dbReference type="WormBase" id="Y45G5AL.2a">
        <property type="protein sequence ID" value="CE47378"/>
        <property type="gene ID" value="WBGene00044528"/>
        <property type="gene designation" value="lgc-29"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054847_1_0_1"/>
    <dbReference type="OMA" id="FPMDTHT"/>
    <dbReference type="OrthoDB" id="5866477at2759"/>
    <dbReference type="PhylomeDB" id="Q4R170"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q4R170">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000027">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000124">
        <property type="entry name" value="Protein CBG26995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022265127" evidence="5">
        <location>
            <begin position="21"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="39"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="261"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD74318.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WormBase" id="Y45G5AL.2a"/>
        </source>
    </evidence>
    <sequence length="396" mass="45952" checksum="820B193902C58E0E" modified="2012-05-16" version="2">MSRIYSLLFYLMVPLWSTDSQSMTSEQMANYKRFLGHQDRLFEKLFKSYDPGINAIYTLHSVPETNGTVHPPRFEITIQLSMMKLVEVVEPEEKATFLFDYRADWYDTRLSWDPEDYGGINHIYVPRSKVWIPETTIVDCSEIKVFDNEYTRYAWLHSNGSIGMYIASVTSVVCQMDVYKFPMDTHTCSVNFLFMTYQLEEFTIVGKTGTLPRPVEQLGNGEWQMKSIQIAFEPVVDNLTYLTKFEATFSRNPGFYIVLVMIPAYFINVLSIVALFMDINNRSEKFTVGMTNIMSMSFILVILAEDLPKTKNLPILAIYTVTSLAIMLCSLTAVVALPKLKAYYANRSLARGEKIPKNDEVPRTFWERIKFYFKVEYVFMLVFQIANFVNFIIIFT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-01" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6I6D4-2</accession>
    <name>CLUA1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform 2 of Clusterin-associated protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dyf-3</name>
        <name evidence="1" type="ORF">C04C3.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="J. Mol. Biol." volume="346" first="677" last="687">
            <title>The dyf-3 gene encodes a novel protein required for sensory cilium formation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Murayama T."/>
                <person name="Toh Y."/>
                <person name="Ohshima Y."/>
                <person name="Koga M."/>
            </authorList>
            <dbReference type="PubMed" id="15713455"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2004.12.005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="1448" last="1461">
            <title>Dynein-driven retrograde intraflagellar transport is triphasic in C. elegans sensory cilia.</title>
            <authorList>
                <person name="Yi P."/>
                <person name="Li W.J."/>
                <person name="Dong M.Q."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="28479320"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.04.015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN IFT COMPLEX B</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q6I6D4-3</id>
            <name>3</name>
            <name>dyf-3c</name>
            <sequence type="described" ref="VSP_046489"/>
        </isoform>
        <isoform>
            <id>Q6I6D4-1</id>
            <name>1</name>
            <name>dyf-3a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q6I6D4-2</id>
            <name>2</name>
            <name>dyf-3b</name>
            <sequence type="described" ref="VSP_046490"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001021296.1">
        <property type="nucleotide sequence ID" value="NM_001026125.3"/>
    </dbReference>
    <dbReference type="WormBase" id="C04C3.5c">
        <property type="protein sequence ID" value="CE38265"/>
        <property type="gene ID" value="WBGene00001119"/>
        <property type="gene designation" value="dyf-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="C04C3.5a"/>
        </source>
    </evidence>
    <sequence length="393" mass="45864" checksum="8C83A15EC5ED197B" modified="2013-05-01" version="2">MTRSLRYPRLMSIENFRTPNFQLVAELLEWIVKKFEPESNLDAHEVQTEADRVAFIKNAVLLMLQNSRIKMNPKKLYQADGHAVQELLPAMKILYQAKAEDPNTDNSPKWTQVKNKLSSKMQEVRITRQLSSQLPETGALLSELLSRQEFISQQHERAASRAVPLAEAEKVLQATVQNIAQETEQLSNKLNNVASDEAELDEKIERKKREYEQLQKRFAKLQSFRPQYMDEYERFEERLKKLYEVYVLNFRNLSYLRKVHDDLARSERQRQEELEKAMRMAVEKMRLEQEKKDAIGLHDDDGSDAPLVDRRQSVRKVYGNMMGGDASDDDEDDEDDEDDEIIRMDDNVAQHHKRELHRQEEDEERSEADYMVGITTAHVADDAKSDLSSGDDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-01" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6I6D4-3</accession>
    <name>CLUA1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName>Isoform 3 of Clusterin-associated protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dyf-3</name>
        <name evidence="1" type="ORF">C04C3.5</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3)</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="J. Mol. Biol." volume="346" first="677" last="687">
            <title>The dyf-3 gene encodes a novel protein required for sensory cilium formation in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Murayama T."/>
                <person name="Toh Y."/>
                <person name="Ohshima Y."/>
                <person name="Koga M."/>
            </authorList>
            <dbReference type="PubMed" id="15713455"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2004.12.005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3)</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="1448" last="1461">
            <title>Dynein-driven retrograde intraflagellar transport is triphasic in C. elegans sensory cilia.</title>
            <authorList>
                <person name="Yi P."/>
                <person name="Li W.J."/>
                <person name="Dong M.Q."/>
                <person name="Ou G."/>
            </authorList>
            <dbReference type="PubMed" id="28479320"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.04.015"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN IFT COMPLEX B</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q6I6D4-3</id>
            <name>3</name>
            <name>dyf-3c</name>
            <sequence type="described" ref="VSP_046489"/>
        </isoform>
        <isoform>
            <id>Q6I6D4-2</id>
            <name>2</name>
            <name>dyf-3b</name>
            <sequence type="described" ref="VSP_046490"/>
        </isoform>
        <isoform>
            <id>Q6I6D4-1</id>
            <name>1</name>
            <name>dyf-3a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001367377.1">
        <property type="nucleotide sequence ID" value="NM_001380145.1"/>
    </dbReference>
    <dbReference type="WormBase" id="C04C3.5a">
        <property type="protein sequence ID" value="CE16811"/>
        <property type="gene ID" value="WBGene00001119"/>
        <property type="gene designation" value="dyf-3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000312" key="1">
        <source>
            <dbReference type="WormBase" id="C04C3.5a"/>
        </source>
    </evidence>
    <sequence length="331" mass="38563" checksum="8F1DFE7326355485" modified="2013-05-01" version="2">MLQNSRIKMNPKKLYQADGHAVQELLPAMKILYQAKAEDPNTDNSPKWTQVKNKLSSKMQEVRITRQLSSQLPETGALLSELLSRQEFISQQHERAASRAVPLAEAEKVLQATVQNIAQETEQLSNKLNNVASDEAELDEKIERKKREYEQLQKRFAKLQSFRPQYMDEYERFEERLKKLYEVYVLNFRNLSYLRKVHDDLARSERQRQEELEKAMRMAVEKMRLEQEKKDAIGLHDDDGSDAPLVDRRQSVRKVYGNMMGGDASDDDEDDEDDEDDEIIRMDDNVAQHHKRELHRQEEDEERSEADYMVGITTAHVADDAKSDLSSGDDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="175" xmlns="https://uniprot.org/uniprot">
    <accession>Q93727-2</accession>
    <name>SPTF1_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Specificity protein transcription factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sptf-1</name>
        <name evidence="4" type="ORF">F45H11.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2015" name="Genetics" volume="200" first="123" last="134">
            <title>Cis- and trans-regulatory mechanisms of gene expression in the ASJ sensory neuron of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Gonzalez-Barrios M."/>
                <person name="Fierro-Gonzalez J.C."/>
                <person name="Krpelanova E."/>
                <person name="Mora-Lorca J.A."/>
                <person name="Pedrajas J.R."/>
                <person name="Penate X."/>
                <person name="Chavez S."/>
                <person name="Swoboda P."/>
                <person name="Jansen G."/>
                <person name="Miranda-Vizuete A."/>
            </authorList>
            <dbReference type="PubMed" id="25769980"/>
            <dbReference type="DOI" id="10.1534/genetics.115.176172"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q93727-2</id>
            <name evidence="5">b</name>
            <sequence type="described" ref="VSP_061148"/>
        </isoform>
        <isoform>
            <id>Q93727-1</id>
            <name evidence="4">a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="RefSeq" id="NP_001359696.1">
        <property type="nucleotide sequence ID" value="NM_001373640.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F45H11.1b">
        <property type="protein sequence ID" value="CE38353"/>
        <property type="gene ID" value="WBGene00009743"/>
        <property type="gene designation" value="sptf-1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="25769980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000312" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F45H11.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="WormBase" id="F45H11.1b"/>
        </source>
    </evidence>
    <sequence length="295" mass="31456" checksum="FFE2B252061B9E94" modified="1998-06-01" version="2">MGGASSPRIPSRRSAPYFTSLAFFGSSYIKVKNNRNKMLNPTDAASVALSFSVPFQMSGENPLSKLVEHCNKFVPGADIKMKAEPAKPESLLLPTDMNAYSPYLATPNWWVDQTGWPQLYPTVTTASSVDVYQNYLASSQLGGLLSSSVSAVASQLPAGINAQSALNITSQQRTIAKSFQHTKPMASSSSIPSVLTASNSSANSLVSSGSESVSARGTSGSGGTGKYPSSRTANKCECPNCHEIEKFGPNAIAARKRGVHNCHIAGCGKVYNKSSHLKAHLRWHSGERQMVRKPV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q94218-2</accession>
    <name>UFSP_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform b of Ufm1-specific protease</fullName>
            <shortName evidence="1">UfSP</shortName>
            <ecNumber evidence="2">3.4.22.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Odorant response abnormal protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">odr-8</name>
        <name evidence="4" type="synonym">ufsp-2</name>
        <name evidence="4" type="ORF">F38A5.1</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Cell" volume="93" first="455" last="466">
            <title>Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein.</title>
            <authorList>
                <person name="Dwyer N.D."/>
                <person name="Troemel E.R."/>
                <person name="Sengupta P."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="9590179"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(00)81173-3"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <source>
            <strain>Bristol N2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Nature" volume="419" first="899" last="903">
            <title>Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli.</title>
            <authorList>
                <person name="de Bono M."/>
                <person name="Tobin D.M."/>
                <person name="Davis M.W."/>
                <person name="Avery L."/>
                <person name="Bargmann C.I."/>
            </authorList>
            <dbReference type="PubMed" id="12410303"/>
            <dbReference type="DOI" id="10.1038/nature01169"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="J. Biol. Chem." volume="288" first="10661" last="10671">
            <title>The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans.</title>
            <authorList>
                <person name="Hertel P."/>
                <person name="Daniel J."/>
                <person name="Stegehake D."/>
                <person name="Vaupel H."/>
                <person name="Kailayangiri S."/>
                <person name="Gruel C."/>
                <person name="Woltersdorf C."/>
                <person name="Liebau E."/>
            </authorList>
            <dbReference type="PubMed" id="23449979"/>
            <dbReference type="DOI" id="10.1074/jbc.M113.458000"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="PLoS Genet." volume="10" first="E1004082" last="E1004082">
            <title>An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism.</title>
            <authorList>
                <person name="Chen C."/>
                <person name="Itakura E."/>
                <person name="Weber K.P."/>
                <person name="Hegde R.S."/>
                <person name="de Bono M."/>
            </authorList>
            <dbReference type="PubMed" id="24603482"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1004082"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH ODR-4</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF CYS-421 AND HIS-547</scope>
    </reference>
    <reference evidence="5" key="6">
        <citation type="journal article" date="2018" name="FEBS Lett." volume="592" first="263" last="273">
            <title>Structural basis for Ufm1 recognition by UfSP.</title>
            <authorList>
                <person name="Kim K.H."/>
                <person name="Ha B.H."/>
                <person name="Kim E.E."/>
            </authorList>
            <dbReference type="PubMed" id="29251776"/>
            <dbReference type="DOI" id="10.1002/1873-3468.12951"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.29 ANGSTROMS) OF 25-589 IN COMPLEX WITH UFM-1</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>MUTAGENESIS OF TYR-409; CYS-421; ASP-458; TRP-469; ARG-488; HIS-547 AND ASN-578</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q94218-1</id>
            <name>a</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q94218-2</id>
            <name>b</name>
            <sequence type="described" ref="VSP_023644"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="2"/>
    <dbReference type="RefSeq" id="NP_001023189.1">
        <property type="nucleotide sequence ID" value="NM_001028018.2"/>
    </dbReference>
    <dbReference type="WormBase" id="F38A5.1b">
        <property type="protein sequence ID" value="CE33641"/>
        <property type="gene ID" value="WBGene00018160"/>
        <property type="gene designation" value="odr-8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="DisProt" id="DP03322"/>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9NUQ7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="29251776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="9590179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="WormBase" id="F38A5.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="5">
        <source>
            <dbReference type="PDB" id="5XDA"/>
        </source>
    </evidence>
    <sequence length="575" mass="65123" checksum="C45693C8CC4095D9" modified="1997-02-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2026-01-28" version="172" xmlns="https://uniprot.org/uniprot">
    <accession>Q95QB6</accession>
    <name>Q95QB6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">prps-1</name>
        <name evidence="14" type="ORF">CELE_R151.2</name>
        <name evidence="16" type="ORF">R151.2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. The active form is probably a hexamer composed of 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CCD70753.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_498587.2">
        <property type="nucleotide sequence ID" value="NM_066186.7"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q95QB6"/>
    <dbReference type="SMR" id="Q95QB6"/>
    <dbReference type="PeptideAtlas" id="Q95QB6"/>
    <dbReference type="GeneID" id="176016"/>
    <dbReference type="UCSC" id="R151.2d.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00020107"/>
    <dbReference type="CTD" id="176016"/>
    <dbReference type="WormBase" id="R151.2c">
        <property type="protein sequence ID" value="CE47835"/>
        <property type="gene ID" value="WBGene00020107"/>
        <property type="gene designation" value="prps-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020107">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q95QB6">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000011">
        <property type="entry name" value="Putative ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD70753.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="R151.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PeptideAtlas" id="Q95QB6"/>
        </source>
    </evidence>
    <sequence length="318" mass="34606" checksum="DC5E676DD9913742" modified="2013-02-06" version="2">MSPTVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIASSCRVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNWQTSVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADKVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDENMKKCSKIQCIDISMILAEAIRRTHNGESVSYLFSHVPIC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>Q9BMK9-2</accession>
    <name>CLH3_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isoform b of Chloride channel protein clh-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">clh-3</name>
        <name evidence="12" type="synonym">clc-3</name>
        <name evidence="12" type="ORF">E04F6.11</name>
    </gene>
    <organism>
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="1999" name="J. Biol. Chem." volume="274" first="34238" last="34244">
            <title>CLC chloride channels in Caenorhabditis elegans.</title>
            <authorList>
                <person name="Schriever A.M."/>
                <person name="Friedrich T."/>
                <person name="Pusch M."/>
                <person name="Jentsch T.J."/>
            </authorList>
            <dbReference type="PubMed" id="10567397"/>
            <dbReference type="DOI" id="10.1074/jbc.274.48.34238"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain evidence="10">Bristol N2</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2000" name="Am. J. Physiol." volume="279" first="C2052" last="2066">
            <title>Into ion channel and transporter function. Caenorhabditis elegans ClC-type chloride channels: novel variants and functional expression.</title>
            <authorList>
                <person name="Nehrke K."/>
                <person name="Begenisich T."/>
                <person name="Pilato J."/>
                <person name="Melvin J.E."/>
            </authorList>
            <dbReference type="PubMed" id="11078724"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2001" name="Curr. Biol." volume="11" first="161" last="170">
            <title>CLH-3, a ClC-2 anion channel ortholog activated during meiotic maturation in C. elegans oocytes.</title>
            <authorList>
                <person name="Rutledge E."/>
                <person name="Bianchi L."/>
                <person name="Christensen M."/>
                <person name="Boehmer C."/>
                <person name="Morrison R."/>
                <person name="Broslat A."/>
                <person name="Beld A.M."/>
                <person name="George A.L."/>
                <person name="Greenstein D."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="11231150"/>
            <dbReference type="DOI" id="10.1016/S0960-9822(01)00051-3"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="9" key="5">
        <citation type="journal article" date="2002" name="J. Cell Biol." volume="158" first="435" last="444">
            <title>Cell cycle- and swelling-induced activation of a Caenorhabditis elegans ClC channel is mediated by CeGLC-7alpha/beta phosphatases.</title>
            <authorList>
                <person name="Rutledge E."/>
                <person name="Denton J."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="12163466"/>
            <dbReference type="DOI" id="10.1083/jcb.200204142"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEPHOSPHORYLATION BY GSP-1/2</scope>
    </reference>
    <reference evidence="9" key="6">
        <citation type="journal article" date="2004" name="J. Physiol. (Lond.)" volume="555" first="97" last="114">
            <title>Alternative splicing of N- and C-termini of a C. elegans ClC channel alters gating and sensitivity to external Cl- and H+.</title>
            <authorList>
                <person name="Denton J."/>
                <person name="Nehrke K."/>
                <person name="Rutledge E."/>
                <person name="Morrison R."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="14565992"/>
            <dbReference type="DOI" id="10.1113/jphysiol.2003.053165"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVATION MECHANISM</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="9" key="7">
        <citation type="journal article" date="2005" name="J. Gen. Physiol." volume="125" first="113" last="125">
            <title>GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel.</title>
            <authorList>
                <person name="Denton J."/>
                <person name="Nehrke K."/>
                <person name="Yin X."/>
                <person name="Morrison R."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="15684092"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH GCK-3</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="9" key="8">
        <citation type="journal article" date="2006" name="Biophys. J." volume="90" first="3570" last="3581">
            <title>Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity.</title>
            <authorList>
                <person name="He L."/>
                <person name="Denton J."/>
                <person name="Nehrke K."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="16500974"/>
            <dbReference type="DOI" id="10.1529/biophysj.105.078295"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVATION MECHANISM</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF GLU-167</scope>
    </reference>
    <reference evidence="9" key="9">
        <citation type="journal article" date="2008" name="EMBO Rep." volume="9" first="70" last="75">
            <title>Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.</title>
            <authorList>
                <person name="Hisamoto N."/>
                <person name="Moriguchi T."/>
                <person name="Urushiyama S."/>
                <person name="Mitani S."/>
                <person name="Shibuya H."/>
                <person name="Matsumoto K."/>
            </authorList>
            <dbReference type="PubMed" id="18049475"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7401128"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="9" key="10">
        <citation type="journal article" date="2009" name="J. Gen. Physiol." volume="133" first="29" last="42">
            <title>Identification of regulatory phosphorylation sites in a cell volume- and Ste20 kinase-dependent ClC anion channel.</title>
            <authorList>
                <person name="Falin R.A."/>
                <person name="Morrison R."/>
                <person name="Ham A.J."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="19088383"/>
            <dbReference type="DOI" id="10.1085/jgp.200810080"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>PHOSPHORYLATION AT SER-742 AND SER-747</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>MUTAGENESIS OF SER-742; THR-744 AND SER-747</scope>
    </reference>
    <reference evidence="9" key="11">
        <citation type="journal article" date="2010" name="Channels" volume="4" first="289" last="301">
            <title>Unique gating properties of C. elegans ClC anion channel splice variants are determined by altered CBS domain conformation and the R-helix linker.</title>
            <authorList>
                <person name="Dave S."/>
                <person name="Sheehan J.H."/>
                <person name="Meiler J."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="20581474"/>
            <dbReference type="DOI" id="10.4161/chan.4.4.12445"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF GLU-167; PHE-559; LEU-833; ALA-836 AND ILE-837</scope>
    </reference>
    <reference evidence="9" key="12">
        <citation type="journal article" date="2012" name="Biophys. J." volume="103" first="1706" last="1718">
            <title>CLC anion channel regulatory phosphorylation and conserved signal transduction domains.</title>
            <authorList>
                <person name="Miyazaki H."/>
                <person name="Yamada T."/>
                <person name="Parton A."/>
                <person name="Morrison R."/>
                <person name="Kim S."/>
                <person name="Beth A.H."/>
                <person name="Strange K."/>
            </authorList>
            <dbReference type="PubMed" id="23083714"/>
            <dbReference type="DOI" id="10.1016/j.bpj.2012.09.001"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF TYR-232; SER-742; SER-747 AND HIS-805</scope>
    </reference>
    <reference evidence="9" key="13">
        <citation type="journal article" date="2014" name="J. Neurosci." volume="34" first="764" last="775">
            <title>The voltage-gated anion channels encoded by clh-3 regulate egg laying in C. elegans by modulating motor neuron excitability.</title>
            <authorList>
                <person name="Branicky R."/>
                <person name="Miyazaki H."/>
                <person name="Strange K."/>
                <person name="Schafer W.R."/>
            </authorList>
            <dbReference type="PubMed" id="24431435"/>
            <dbReference type="DOI" id="10.1523/JNEUROSCI.3112-13.2014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF VAL-495</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 3 4 5">Voltage-gated chloride channel (PubMed:10567397, PubMed:11078724, PubMed:11231150). Sensitive to depolarizing conditioning voltages, requires stronger voltages for activation and activation is slower, is inhibited by low concentrations of chloride and is activated by low pH. Channel gating properties are conferred by the cytoplasmic C-terminus (PubMed:14565992, PubMed:16500974).</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q9BMK9-2</id>
            <name evidence="10">b</name>
            <name evidence="8">clh-3a</name>
            <sequence type="described" ref="VSP_057744 VSP_057741 VSP_057742 VSP_057743"/>
        </isoform>
        <isoform>
            <id>Q9BMK9-1</id>
            <name evidence="12">a</name>
            <name evidence="7">clh-3b</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <feature type="mutagenesis site" description="Constitutive activation, loss of pH sensitivity, loss of sensitivity to chloride levels and conditioning depolarizing voltages; in isoform b." evidence="5">
        <original>E</original>
        <variation>A</variation>
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Increased sensitivity to MTSET-mediated inhibition; in isoform a and isoform b. Inhibition is slower; in isoform a. Reduced sensitivity to MTSET-mediated inhibition; when associated with D-559; in isoform a." evidence="5 6">
        <original>E</original>
        <variation>C</variation>
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="10567397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="11078724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="11231150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="14565992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16500974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="19088383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="10567397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="14565992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="EMBL" id="AAF13165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="WormBase" id="E04F6.11a"/>
        </source>
    </evidence>
    <sequence length="811" mass="90214" checksum="BF7AF7A7F531549A" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q9GUM8</accession>
    <name>Q9GUM8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 35 member F1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CELE_Y73E7A.3</name>
        <name evidence="10 12" type="ORF">Y73E7A.3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative solute transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CCD73534.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9GUM8"/>
    <dbReference type="UCSC" id="Y73E7A.3">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00022270"/>
    <dbReference type="WormBase" id="Y73E7A.3b">
        <property type="protein sequence ID" value="CE46767"/>
        <property type="gene ID" value="WBGene00022270"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022270">
        <property type="expression patterns" value="Expressed in larva and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9GUM8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD73534.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="Y73E7A.3b"/>
        </source>
    </evidence>
    <sequence length="339" mass="37101" checksum="BD2E11BF2F6AC17E" modified="2012-01-25" version="4">MGGERAYSFSYHRSVYDEHAGERRPLVEDRRRTAAPPSHLTAKRFPRQYGNYGMTNCGAESTSAPPQANGHLRPPGIQPHRNPFTPPPLPSPDEFDDAINCSPCCDDPNVSRTFKALILGQILSLCLCGTGVSSQLLVNQNVNAPAAQAFSNYFLLCFVYCISLACKNDENGLVVVLRKRGWRYLILAIIDVEANYMIVKAYQYTNLTSVQLLDCATIPTVLFLSWLFLSVRYLASHILGVTICIIGIACVIWADALGDKGALDGGSNKVLGDILCLAAAVMYAICNVAEEFLVKQHSRTEYLGMLGLFGCIVSGVQTGPSMTFVLWNLIGQKSVIVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2025-10-08" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XWA1</accession>
    <name>Q9XWA1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_Y40H7A.2</name>
        <name evidence="2 4" type="ORF">Y40H7A.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA22065.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_502829.2">
        <property type="nucleotide sequence ID" value="NM_070428.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XWA1"/>
    <dbReference type="PaxDb" id="6239-Y40H7A.2"/>
    <dbReference type="GeneID" id="189801"/>
    <dbReference type="UCSC" id="Y40H7A.2">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012742"/>
    <dbReference type="CTD" id="189801"/>
    <dbReference type="WormBase" id="Y40H7A.2a">
        <property type="protein sequence ID" value="CE42820"/>
        <property type="gene ID" value="WBGene00012742"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S02V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074434_0_0_1"/>
    <dbReference type="OMA" id="ETEGHCT"/>
    <dbReference type="OrthoDB" id="5815019at2759"/>
    <dbReference type="PhylomeDB" id="Q9XWA1"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012742">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF9">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22065.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="Y40H7A.2a"/>
        </source>
    </evidence>
    <sequence length="220" mass="25353" checksum="D2F000BE9C8EF0EB" modified="2008-09-02" version="2">MPTVDKIRESILEMSKQNESHKFYETLRPEAFCPLKLKIGGDGDSGKVTCDPKRARNDCTMMSLGLNDQIQFDEEIQSITDYRCNIIGADMARQNATTQEKYAKMKGQLFVGNVPDTLKLYRMMIDSESKEVEILKIDIESSEHAALEPFLKNYFVCQILIEIHGLPAKQLEMLRKISRLGFRMFNFERNPSCTICCEYSFINEMCMSRYQVIPMVSLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XWA5</accession>
    <name>Q9XWA5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase FkbM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y40H7A.4</name>
        <name evidence="3 5" type="ORF">Y40H7A.4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAA22061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T26791">
        <property type="entry name" value="T26791"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001076727.1">
        <property type="nucleotide sequence ID" value="NM_001083258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XWA5"/>
    <dbReference type="PaxDb" id="6239-Y40H7A.4a"/>
    <dbReference type="GeneID" id="189803"/>
    <dbReference type="KEGG" id="cel:CELE_Y40H7A.4"/>
    <dbReference type="UCSC" id="Y40H7A.4b">
        <property type="organism name" value="c. elegans"/>
    </dbReference>
    <dbReference type="AGR" id="WB:WBGene00012744"/>
    <dbReference type="CTD" id="189803"/>
    <dbReference type="WormBase" id="Y40H7A.4a">
        <property type="protein sequence ID" value="CE21815"/>
        <property type="gene ID" value="WBGene00012744"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S02V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074434_0_1_1"/>
    <dbReference type="OMA" id="AHIMEVE"/>
    <dbReference type="OrthoDB" id="5815019at2759"/>
    <dbReference type="PhylomeDB" id="Q9XWA5"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00012744">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="Q9XWA5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF5">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="95"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y40H7A.4a"/>
        </source>
    </evidence>
    <sequence length="291" mass="33231" checksum="065ADC31806E026D" modified="1999-11-01" version="1">MVAHFVSSKCAGYFLILVIFILFIANYYRLVILLETIEKLPPDTNYPNHQLLDSDSPIRELRRAALLSADQVQREIIENAVGEDNKNFYQKLRPEAFCPLKIKIGGKGDGGKIVCNPKAIKDDCTLMSLGLNNQVDYEQEIYNITGGNCLLLAADKDPQNMNTLRIFSTLKSHVYVGMIPDNLTIAHIMHSEYKTEVEILKIDIEGGEHTGLEQFLRDFFVCQILIEIHGWPPEHLDMLQKISRYGFRIFNIEPNRLCTRCAEYSFINELCMSQYSVLPLANMIPRNLTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2026-01-28" version="171" xmlns="https://uniprot.org/uniprot">
    <accession>Q9XWF1</accession>
    <name>Q9XWF1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome-b5 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CELE_Y52B11A.3</name>
        <name evidence="8 10" type="ORF">Y52B11A.3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAA21721.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T27107"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="entry name" value="Cyt-b5"/>
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        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B5_1"/>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0349">Heme</keyword>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="134"/>
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        <location>
            <begin position="285"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAA21721.3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WormBase" id="Y52B11A.3a"/>
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    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PeptideAtlas" id="Q9XWF1"/>
        </source>
    </evidence>
    <sequence length="538" mass="60596" checksum="5112C398FC766ED6" modified="2021-06-02" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>S6FD08</accession>
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        <submittedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">CELE_R11E3.5</name>
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    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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    <dbReference type="RefSeq" id="NP_001293849.1">
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    <dbReference type="AGR" id="WB:WBGene00003694"/>
    <dbReference type="CTD" id="177248"/>
    <dbReference type="WormBase" id="R11E3.5d">
        <property type="protein sequence ID" value="CE48438"/>
        <property type="gene ID" value="WBGene00003694"/>
        <property type="gene designation" value="nhr-104"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830034at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003694">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6FD08">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011:SF13">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hormone_recep"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="50"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDG24118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="R11E3.5d"/>
        </source>
    </evidence>
    <sequence length="325" mass="37909" checksum="7FFF5A4308EECD00" modified="2013-10-16" version="1">MKKESIQKHRDIYGRRNPENRALIISPSTSQLQVTIPITLLSSVKRNYAELENVREIVHRMDGFSMFLKPAPRGQTYKETYRLLLREFYLVSDWVSNCFPLFKELPNSQKDILLRNFYLTFYNLEAGFFACQHNKIDVWFLPNGNFIDCQNLEAFYYDPHNQQPMTSADAARLFKGTCTECKRNVLEPMLRENVTQFEFLALAALLLFDTGLEDQSDDCMDLCRNVRTLIQREMIQYYSNKHLDEYPLRMADVISLIPRVQKAAQKMQSDMEIGHLFNTYAAEKSFFENCMGKETSNEHNPSPRGGKFENEKENSVFLIIGTIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>S6FD15</accession>
    <name>S6FD15_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">pqn-21</name>
        <name evidence="5" type="ORF">C37A2.5</name>
        <name evidence="3" type="ORF">CELE_C37A2.5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDG24123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293281.1">
        <property type="nucleotide sequence ID" value="NM_001306352.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6FD15"/>
    <dbReference type="PeptideAtlas" id="S6FD15"/>
    <dbReference type="GeneID" id="172398"/>
    <dbReference type="AGR" id="WB:WBGene00004111"/>
    <dbReference type="CTD" id="172398"/>
    <dbReference type="WormBase" id="C37A2.5d">
        <property type="protein sequence ID" value="CE48475"/>
        <property type="gene ID" value="WBGene00004111"/>
        <property type="gene designation" value="pqn-21"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356117_0_0_1"/>
    <dbReference type="OrthoDB" id="5877875at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004111">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6FD15">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDG24123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="C37A2.5d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="S6FD15"/>
        </source>
    </evidence>
    <sequence length="500" mass="54429" checksum="E0DCE5BE3DABBF13" modified="2013-10-16" version="1">MDTPPGSQMTLEVTVMYRTKNSLAFRVKGCDLIGFIGDGLPPMASSLTNNIASSMGNNNNKKKTASSSGNEEGKDGRSSSASSNGRGARGGSVLKDGKEDENQNNEQYGSKKCELVEVDVAQLHDCHYDGCEKRFQKTTDLEYHISKNHKRRVMMYESICTQTSISSLETQNNSTQIDDDLPPMPQMPILKKEVPIKTPIGNVYEDLSDDDSETKPTDLVLKTPSSSASSAVATLMGIAQVSSSTTSATTSVVPPVGAQRSTPATPVSAKIGINPSMVANALAEKNKQQQQQQQKLNQLQPPHNPSLSTAPSSSSAQPPTMIQAHPMAGVFIPPPFHPAMMNPQMAAMMDQQRIAVAMSQQQQMSRTPSRQTISVSDSHKIHELAKSRENQQRQQSATPKTPSESVSTTGVVTPQRQFLPPQMMQPGTPQSILLQQQQQQQQQQQQAAAQHQIIQQMQMQMQRGMAPQMANQELLMMMMGMPHMVQGVPGFPGVPQLPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>S6FD20</accession>
    <name>S6FD20_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">hum-4</name>
        <name evidence="12" type="ORF">CELE_F46C3.3</name>
        <name evidence="14" type="ORF">F46C3.3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CDG24128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294791.1">
        <property type="nucleotide sequence ID" value="NM_001307862.4"/>
    </dbReference>
    <dbReference type="SMR" id="S6FD20"/>
    <dbReference type="GeneID" id="181335"/>
    <dbReference type="AGR" id="WB:WBGene00002037"/>
    <dbReference type="CTD" id="181335"/>
    <dbReference type="WormBase" id="F46C3.3g">
        <property type="protein sequence ID" value="CE48421"/>
        <property type="gene ID" value="WBGene00002037"/>
        <property type="gene designation" value="hum-4"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_14_0_1"/>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00002037">
        <property type="expression patterns" value="Expressed in embryo and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6FD20">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.530:FF:000012">
        <property type="entry name" value="Heavy chain, Unconventional Myosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059004">
        <property type="entry name" value="MYO15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26570">
        <property type="entry name" value="MYO15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="731"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="11">
        <location>
            <begin position="861"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="10">
        <location>
            <begin position="1022"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDG24128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F46C3.3g"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="S6FD20"/>
        </source>
    </evidence>
    <sequence length="1338" mass="154302" checksum="E5C83EB02CE10E5A" modified="2013-10-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>S6FD39</accession>
    <name>S6FD39_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">daf-15</name>
        <name evidence="7" type="ORF">C10C5.6</name>
        <name evidence="5" type="ORF">CELE_C10C5.6</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDG24143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293858.1">
        <property type="nucleotide sequence ID" value="NM_001306929.3"/>
    </dbReference>
    <dbReference type="SMR" id="S6FD39"/>
    <dbReference type="GeneID" id="177770"/>
    <dbReference type="AGR" id="WB:WBGene00000911"/>
    <dbReference type="CTD" id="177770"/>
    <dbReference type="WormBase" id="C10C5.6e">
        <property type="protein sequence ID" value="CE48450"/>
        <property type="gene ID" value="WBGene00000911"/>
        <property type="gene designation" value="daf-15"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00000911">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="S6FD39">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="4">
        <location>
            <begin position="67"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1306"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1306"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDG24143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C10C5.6e"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="S6FD39"/>
        </source>
    </evidence>
    <sequence length="1785" mass="203224" checksum="889161869128952A" modified="2013-10-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>U4PRA0</accession>
    <name>U4PRA0_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fln-1</name>
        <name evidence="6" type="ORF">CELE_Y66H1B.2</name>
        <name evidence="8" type="ORF">Y66H1B.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294371.1">
        <property type="nucleotide sequence ID" value="NM_001307442.3"/>
    </dbReference>
    <dbReference type="SMR" id="U4PRA0"/>
    <dbReference type="GeneID" id="176855"/>
    <dbReference type="AGR" id="WB:WBGene00022048"/>
    <dbReference type="CTD" id="176855"/>
    <dbReference type="WormBase" id="Y66H1B.2s">
        <property type="protein sequence ID" value="CE48659"/>
        <property type="gene ID" value="WBGene00022048"/>
        <property type="gene designation" value="fln-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022048">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PRA0">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21230">
        <property type="entry name" value="CH_FLN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000140">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001719">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001876">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001886">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002032">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000096">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="120"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="235"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="409"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="504"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="601"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="789"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1290"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1379"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1471"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1588"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1664"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1778"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1855"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1980"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDH93099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="Y66H1B.2s"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="U4PRA0"/>
        </source>
    </evidence>
    <sequence length="2074" mass="225568" checksum="572928A6F8FAA5FA" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>U4PRA9</accession>
    <name>U4PRA9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reelin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ORF">C23H5.8</name>
        <name evidence="2" type="ORF">CELE_C23H5.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294379.1">
        <property type="nucleotide sequence ID" value="NM_001307450.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U4PRA9"/>
    <dbReference type="GeneID" id="177007"/>
    <dbReference type="AGR" id="WB:WBGene00016027"/>
    <dbReference type="CTD" id="177007"/>
    <dbReference type="WormBase" id="C23H5.8d">
        <property type="protein sequence ID" value="CE48997"/>
        <property type="gene ID" value="WBGene00016027"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5824843at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016027">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PRA9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004653568" evidence="1">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDH93110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C23H5.8d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PeptideAtlas" id="U4PRA9"/>
        </source>
    </evidence>
    <sequence length="200" mass="21822" checksum="6B91CC1EC45AB6B5" modified="2013-12-11" version="1">MANFAYLRLYLTIILSFAVQTSGNIGKCVLSSAPPSWLSTNGTGILEYATAGHPTNGTSFCIEGNHDQKTAHVAYHIDLGSEVLAPESVEHSFSENLGSQNGCVNNNTGVVYCFAICLNETLQNMVIESALKSNQPSVVAQDIQKTTQLDWAITVDYNDPNTHLNASVFLVEDAWCSVYVGIRPKLGFDWLYEIQLGKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>U4PRB3</accession>
    <name>U4PRB3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DENN domain type RAB GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">denn-4</name>
        <name evidence="6" type="ORF">CELE_F52C12.4</name>
        <name evidence="8" type="ORF">F52C12.4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDH93115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001294384.1">
        <property type="nucleotide sequence ID" value="NM_001307455.3"/>
    </dbReference>
    <dbReference type="SMR" id="U4PRB3"/>
    <dbReference type="GeneID" id="186100"/>
    <dbReference type="KEGG" id="cel:CELE_F52C12.4"/>
    <dbReference type="AGR" id="WB:WBGene00018681"/>
    <dbReference type="CTD" id="186100"/>
    <dbReference type="WormBase" id="F52C12.4a">
        <property type="protein sequence ID" value="CE48580"/>
        <property type="gene ID" value="WBGene00018681"/>
        <property type="gene designation" value="denn-4"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75250at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018681">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PRB3">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
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            <end position="206"/>
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        <location>
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            <end position="661"/>
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            <dbReference type="EMBL" id="CDH93115.1"/>
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    <sequence length="1533" mass="173091" checksum="4C0F0A223EEF9ED7" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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    </dbReference>
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        <location>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDH93120.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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    </evidence>
    <sequence length="1533" mass="173146" checksum="A544B9B6E8C66B18" modified="2013-12-11" version="1"> </sequence>
</entry>
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        <submittedName>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
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        <property type="protein sequence ID" value="CDH93125.1"/>
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        <property type="nucleotide sequence ID" value="NM_001380071.1"/>
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    <dbReference type="AGR" id="WB:WBGene00018678"/>
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    <dbReference type="WormBase" id="F52C12.1b">
        <property type="protein sequence ID" value="CE48525"/>
        <property type="gene ID" value="WBGene00018678"/>
        <property type="gene designation" value="tdpo-1"/>
    </dbReference>
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        <property type="component" value="Chromosome IV"/>
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PRC2">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Phospholipase D/nuclease"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="223"/>
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        <location>
            <position position="225"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="246"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDH93125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WormBase" id="F52C12.1b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PeptideAtlas" id="U4PRC2"/>
        </source>
    </evidence>
    <sequence length="318" mass="36547" checksum="5D4618BB1BC54CCC" modified="2013-12-11" version="1">MSILEDEDGRFHVIVSTANLVPDDWEFKTQQFYYNFGVKIASGTVPRSDFQDDLLEYLSMYRNQLDTWKQLLQKVDFSQISDRLIFSTPGYHTDPPTQRPGHPRLFRILSEKFPFDASYEHTERCTFVAQCSSIGSLGSAPINWFRGQFLQSLEGANPSPKQKPAKMYLVFPSVEDVRTSCQGYAGGCSVPYRNSVHARQKWLQGNMCKWRSNAKRRTNAVPHCKTYVKYDKKVAIWQLLTSANLSKAAWGEVSFNKSKNVEQLMIRSWEMGVLITDPSRFNIPFDYPLVPYSATDEPFVTDKKHEKPDILGCIWTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>U4PRC7</accession>
    <name>U4PRC7_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase-activating protein pac-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">pac-1</name>
        <name evidence="7" type="ORF">C04D8.1</name>
        <name evidence="5" type="ORF">CELE_C04D8.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CDH93130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001293657.1">
        <property type="nucleotide sequence ID" value="NM_001306728.4"/>
    </dbReference>
    <dbReference type="SMR" id="U4PRC7"/>
    <dbReference type="PeptideAtlas" id="U4PRC7"/>
    <dbReference type="GeneID" id="176201"/>
    <dbReference type="AGR" id="WB:WBGene00015418"/>
    <dbReference type="CTD" id="176201"/>
    <dbReference type="WormBase" id="C04D8.1f">
        <property type="protein sequence ID" value="CE48596"/>
        <property type="gene ID" value="WBGene00015418"/>
        <property type="gene designation" value="pac-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015418">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="U4PRC7">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01253">
        <property type="entry name" value="PH_ARHGAP21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04395">
        <property type="entry name" value="RhoGAP_ARHGAP21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000058">
        <property type="entry name" value="GTPase-activating protein pac-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF133">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN PAC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="598"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="947"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1276"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1441"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1243"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1277"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1460"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1479"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1499"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1524"/>
            <end position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDH93130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="C04D8.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="U4PRC7"/>
        </source>
    </evidence>
    <sequence length="1563" mass="168668" checksum="E1C77EBB77262C3D" modified="2013-12-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>V6CJA4</accession>
    <name>V6CJA4_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OOcyte Partner of Spe-11 (Oops-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">oops-1</name>
        <name evidence="4" type="ORF">C31H1.8</name>
        <name evidence="2" type="ORF">CELE_C31H1.8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CDK13515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368411.1">
        <property type="nucleotide sequence ID" value="NM_001380244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CJA4"/>
    <dbReference type="SMR" id="V6CJA4"/>
    <dbReference type="GeneID" id="177351"/>
    <dbReference type="AGR" id="WB:WBGene00016291"/>
    <dbReference type="CTD" id="177351"/>
    <dbReference type="WormBase" id="C31H1.8b">
        <property type="protein sequence ID" value="CE49400"/>
        <property type="gene ID" value="WBGene00016291"/>
        <property type="gene designation" value="oops-1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034967_0_0_1"/>
    <dbReference type="OrthoDB" id="5806466at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00016291">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="V6CJA4">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDK13515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="C31H1.8b"/>
        </source>
    </evidence>
    <sequence length="431" mass="49108" checksum="B87E4944A0013FA3" modified="2014-02-19" version="1">MRRLSSGDLNVIRRMTEEIDFDLKFQNIIYDGNEITGETDADNGNDRACFKPGPDYPIDQQMLFLKQCIKKIDTRPPNMYYLTNGWSVDNFEALFKYMIRSGEDCSRDTLLRVEFRDCVVSLKSLYDFIEEYATFKGVKMHSDYVYAIVHSRNEKLERRLRGAIDSFMEIESKIRQARISYVSSFTINSPHTPNVSIIVKFCCLKPCNSDAKTKMRQISVQVDHVTGRSRMSLPDVRQHEGLVCECLGDFSLIRHRPTSVPVTKILDEHPPLIVDEEVRLKSSYQFNPVTGEPIPDDEQQQEQTEIEASIEDPLEINDFVEMFPLILVLLEKAGIQELEDGDAPEKSVSKYPKKRSIVDGASSETCEDTQSVGSSESSEPRSPEFTEYSESEDTAADSETSDSESSSEDEKENMKSSIKELELIKDAPEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>V6CJA9</accession>
    <name>V6CJA9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">zfh-2</name>
        <name evidence="17" type="ORF">CELE_ZC123.3</name>
        <name evidence="19" type="ORF">ZC123.3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDK13520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368413.1">
        <property type="nucleotide sequence ID" value="NM_001380621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V6CJA9"/>
    <dbReference type="SMR" id="V6CJA9"/>
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</entry>
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        <submittedName>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">Bristol N2</strain>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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        <property type="gene ID" value="WBGene00006771"/>
        <property type="gene designation" value="tln-1"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="TaLiN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Talin"/>
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        <property type="entry name" value="Talin 2"/>
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        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
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        <property type="entry name" value="Talin_IBS2B"/>
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    <dbReference type="InterPro" id="IPR054060">
        <property type="entry name" value="TLN1-like_RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015009">
        <property type="entry name" value="Vinculin-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VBS"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
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        <property type="match status" value="3"/>
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    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="I/LWEQ" evidence="4">
        <location>
            <begin position="1269"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1475"/>
            <end position="1502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM63579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y71G12B.11d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="W6SBK6"/>
        </source>
    </evidence>
    <sequence length="1511" mass="162044" checksum="A9A91834B3809253" modified="2014-04-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W6SBL5</accession>
    <name>W6SBL5_CAEEL</name>
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        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CELE_Y71G12B.30</name>
        <name evidence="3 5" type="ORF">Y71G12B.30</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="BX284601">
        <property type="protein sequence ID" value="CDM63589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001306520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6SBL5"/>
    <dbReference type="SMR" id="W6SBL5"/>
    <dbReference type="GeneID" id="3565302"/>
    <dbReference type="AGR" id="WB:WBGene00044347"/>
    <dbReference type="CTD" id="3565302"/>
    <dbReference type="WormBase" id="Y71G12B.30c">
        <property type="protein sequence ID" value="CE49533"/>
        <property type="gene ID" value="WBGene00044347"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_1"/>
    <dbReference type="OrthoDB" id="5774282at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00044347">
        <property type="expression patterns" value="Expressed in adult organism and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="W6SBL5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF506">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="4"/>
            <end position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM63589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="Y71G12B.30c"/>
        </source>
    </evidence>
    <sequence length="204" mass="22584" checksum="C71707DF1D073B3A" modified="2014-04-16" version="1">MFLLRGNHESRPVNMQYGFYNECKRRYSVTLYETFQWAFYCMPLCAIVGGRIMCMHGGIPFGLLSLEQIDEFQRPTDIADVGIPSDLCWADPVSGVVGFQDSPRGAGHVFGEATVKEFNEKFKLDLIVRAHQVVMDGYEFFADKKLVTIFSAPCYCGHFDNLGAVLQVATNMECTINTFGHDLSAAPIKKAPAPAQVAAAPVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARL5</accession>
    <name>A0A0K3ARL5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">itsn-1</name>
        <name evidence="9" type="ORF">CELE_Y116A8C.36</name>
        <name evidence="11" type="ORF">Y116A8C.36</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CTQ86681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299980.1">
        <property type="nucleotide sequence ID" value="NM_001313051.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARL5"/>
    <dbReference type="SMR" id="A0A0K3ARL5"/>
    <dbReference type="PeptideAtlas" id="A0A0K3ARL5"/>
    <dbReference type="GeneID" id="178491"/>
    <dbReference type="AGR" id="WB:WBGene00006405"/>
    <dbReference type="CTD" id="178491"/>
    <dbReference type="WormBase" id="Y116A8C.36f">
        <property type="protein sequence ID" value="CE50630"/>
        <property type="gene ID" value="WBGene00006405"/>
        <property type="gene designation" value="itsn-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00006405">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARL5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd11836">
        <property type="entry name" value="SH3_Intersectin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11837">
        <property type="entry name" value="SH3_Intersectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11839">
        <property type="entry name" value="SH3_Intersectin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000379">
        <property type="entry name" value="ITSN (Intersectin) family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="210"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="329"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="431"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="508"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="574"/>
            <end position="634"/>
        </location>
    </feature>
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        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
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        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CTQ86681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y116A8C.36f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARL5"/>
        </source>
    </evidence>
    <sequence length="634" mass="68943" checksum="025E0B396018DE94" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARM0</accession>
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        <submittedName>
            <fullName evidence="2">DUF2231 domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CELE_K01A2.4</name>
        <name evidence="2 4" type="ORF">K01A2.4</name>
    </gene>
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        <name type="scientific">Caenorhabditis elegans</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="WormBase Consortium"/>
                <person name="WormBase"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A0K3ARM0"/>
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    <dbReference type="WormBase" id="K01A2.4b">
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        <property type="gene ID" value="WBGene00019279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019279">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K01A2.4b"/>
        </source>
    </evidence>
    <sequence length="148" mass="16717" checksum="FCD51082719FE45A" modified="2015-11-11" version="1">MQYNLPPDVKDKKKKLLIGHGISFLIHVIMTYTLFLEWYNAIDPKITVVGAIILMVFVLCLLLLAFGGFVWMLHGKYKNEKAETEFFISLPLFNIACATIYQFVVQLLASQLSIKVPNLASSIAASISVATHMILHTFALFWKSPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <organism evidence="5 6">
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        <lineage>
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            <taxon>Metazoa</taxon>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ELL/occludin family.</text>
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    </dbReference>
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        <property type="gene designation" value="ell-1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="174"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CTQ86686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="Y24D9A.1c"/>
        </source>
    </evidence>
    <sequence length="298" mass="33216" checksum="3EFF1B7AED94CF8A" modified="2015-11-11" version="1">MERITASSKTEKDKVKEKLEEAAKIPSPPKDQKSLPSIVEEDDYYTAPPEPANKRRAHNLAPPPPPPVQVVTPQTTSSQTETGPLPPKRTKRPESSSPQLERSSQPASKLNPIKLAATIAMQPIPKCDPPPPPPSRDTYHHNVASVAVNGGGSTASSRVSSPASSLSSPSQPSCNWEKQFGDIKTLSEAEAYFKQFHKEYPLYMECHEMLTKVSSEFRGLEVKLLTAVALSKTSPSPQNMQNVKQIEKNIQNRYAHFEKDPEFMKARQRHTDLRSKLNVLKTRIGSWEKMRRQSSTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARM6</accession>
    <name>A0A0K3ARM6_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">lin-23</name>
        <name evidence="7" type="ORF">CELE_K10B2.1</name>
        <name evidence="9" type="ORF">K10B2.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300563.1">
        <property type="nucleotide sequence ID" value="NM_001313634.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARM6"/>
    <dbReference type="SMR" id="A0A0K3ARM6"/>
    <dbReference type="GeneID" id="174058"/>
    <dbReference type="AGR" id="WB:WBGene00003009"/>
    <dbReference type="CTD" id="174058"/>
    <dbReference type="WormBase" id="K10B2.1d">
        <property type="protein sequence ID" value="CE50396"/>
        <property type="gene ID" value="WBGene00003009"/>
        <property type="gene designation" value="lin-23"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003009">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARM6">
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    </dbReference>
    <dbReference type="GO" id="GO:0046983">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000004">
        <property type="entry name" value="F-box/WD repeat-containing protein 11 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000117">
        <property type="entry name" value="F-box/WD repeat-containing protein lin-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021977">
        <property type="entry name" value="Beta-TrCP_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01028">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="243"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="286"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CTQ86502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="K10B2.1d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARM6"/>
        </source>
    </evidence>
    <sequence length="610" mass="69701" checksum="208AE85F41ADD536" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARM8</accession>
    <name>A0A0K3ARM8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Secreted frizzled-related protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">sfrp-1</name>
        <name evidence="9" type="ORF">CELE_Y73B6BL.21</name>
        <name evidence="11" type="ORF">Y73B6BL.21</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the secreted frizzled-related protein (sFRP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CTQ86691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299990.1">
        <property type="nucleotide sequence ID" value="NM_001313061.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARM8"/>
    <dbReference type="SMR" id="A0A0K3ARM8"/>
    <dbReference type="GeneID" id="177401"/>
    <dbReference type="AGR" id="WB:WBGene00022242"/>
    <dbReference type="CTD" id="177401"/>
    <dbReference type="WormBase" id="Y73B6BL.21d">
        <property type="protein sequence ID" value="CE26281"/>
        <property type="gene ID" value="WBGene00022242"/>
        <property type="gene designation" value="sfrp-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022242">
        <property type="expression patterns" value="Expressed in embryo and 10 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARM8">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.120:FF:000027">
        <property type="entry name" value="Secreted Frizzled-Related Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF148">
        <property type="entry name" value="SECRETED FRIZZLED-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="FZ" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="8">
        <location>
            <begin position="111"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CTQ86691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y73B6BL.21d"/>
        </source>
    </evidence>
    <sequence length="260" mass="30020" checksum="E30013469EE9750A" modified="2015-11-11" version="1">MRLPNILEHETVSEAIHASKDWESLLRLNCHPDTQRFLCSLFAPVCLMQMDRLILPCKSLCMAVKQGCENRMANYGFPWPEMLSCEKFEDDDMCIKPMQPAKPPAGSSTTCTACSQVATYENLVDQFCRSHLVLKAKVIRDSPTHIRVRNGRSLKKGERRRGVSDVEIRLSSESDGSCPCNIPVKNQNEKLLVMASRQPDGKYLANLVLPWQKEKNFKRAIHQFQRLNCQSLGREIRESASRRPHYYEMRRHNTGRYQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARN3</accession>
    <name>A0A0K3ARN3_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cilia- and flagella-associated protein 251-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_K02E2.7</name>
        <name evidence="2 4" type="ORF">K02E2.7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299997.1">
        <property type="nucleotide sequence ID" value="NM_001313068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARN3"/>
    <dbReference type="SMR" id="A0A0K3ARN3"/>
    <dbReference type="GeneID" id="186882"/>
    <dbReference type="AGR" id="WB:WBGene00010508"/>
    <dbReference type="CTD" id="186882"/>
    <dbReference type="WormBase" id="K02E2.7c">
        <property type="protein sequence ID" value="CE50700"/>
        <property type="gene ID" value="WBGene00010508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00010508">
        <property type="expression patterns" value="Expressed in adult organism and 1 other cell type or tissue"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARN3">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007883">
        <property type="entry name" value="DUF713"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21566:SF2">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21566">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251-LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="K02E2.7c"/>
        </source>
    </evidence>
    <sequence length="347" mass="41325" checksum="E9A2972CECBA849A" modified="2015-11-11" version="1">MEIPSFHITPDMRNLFSECVKEGSYKLFYDLYKSEFEDLAVHLKTVRLPEDTVLHYCVSNFMECVEYLIHTGRGYNYYGHVFSFYRDVDWAILNGDWSRFYWKFRDSVDYVIKKAREQRKIQIYVVEGSARYSSFRSRDRKNPKENSPETRDFEKKSQERENRRRELEEELRKLDLEEKEQLAMISNFKSPEPELQPISPPPSIHDDLINDMDGGMFGSEKTDDSSLEDLQLHVQEMDKNTMLTENFDQDQEELKLFVQELEQNAAETINNSSHQLENALKAEENIETEISEEEASDDEEEDNFHTMLQEQAARHKEEMEKVMKKRAEQKKKLEELNRKVNAIVFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARP1</accession>
    <name>A0A0K3ARP1_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">etr-1</name>
        <name evidence="6" type="ORF">CELE_T01D1.2</name>
        <name evidence="8" type="ORF">T01D1.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368523.1">
        <property type="nucleotide sequence ID" value="NM_001381297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARP1"/>
    <dbReference type="SMR" id="A0A0K3ARP1"/>
    <dbReference type="PeptideAtlas" id="A0A0K3ARP1"/>
    <dbReference type="GeneID" id="173401"/>
    <dbReference type="AGR" id="WB:WBGene00001340"/>
    <dbReference type="CTD" id="173401"/>
    <dbReference type="WormBase" id="T01D1.2n">
        <property type="protein sequence ID" value="CE50589"/>
        <property type="gene ID" value="WBGene00001340"/>
        <property type="gene designation" value="etr-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001340">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARP1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12636">
        <property type="entry name" value="RRM2_Bruno_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12362">
        <property type="entry name" value="RRM3_CELF1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000569">
        <property type="entry name" value="ELAV-Type RNA binding-protein family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000641">
        <property type="entry name" value="ELAV-Type RNA binding-protein family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="377"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CTQ86517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="T01D1.2n"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARP1"/>
        </source>
    </evidence>
    <sequence length="462" mass="49201" checksum="6CDF3AAA7E97D5C5" modified="2015-11-11" version="1">MHHPVQMKPADTENRNERKLFIGQLSKKHNEENLREIFAKFGHIEDCSVLRDQDGKSRGCAFVTFTNRSCAVVATKEMHHSQTMEGCSAPLVVKFADTQKDKDVKTKSMITGSGAGSPKGGAASLLQNLNPALLQQLGGGQNYQAVASLLSLINGQQGQQQQHQQQQNVLGILGTGNPLLGNPAMAAQNQFDAITMAQIAHQQQMLALQGFAVQQGAPSQQQQGLFLAHQYSTNYSTGSPDSASNATDSSSDDNNVMNNRLTPTSKMAQYGYGPLIPRHPAQLYLQQRFPATAAAYGLAGGMAGAKTTSPVAASLANHQQIALTPFAGGAAALDHFQAMQQYALLANLQATGGVGVQATTSAAQMVGNGDVKGPDGANLFIYHLPQDFGDSDLINTFAPFGGILSAKVFIDKVTNLSKCFGFVSYENAQSATNAISAMNGFQIGSKRLKVQLKVDRGNPYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARP5</accession>
    <name>A0A0K3ARP5_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">etr-1</name>
        <name evidence="5" type="ORF">CELE_T01D1.2</name>
        <name evidence="7" type="ORF">T01D1.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CTQ86522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001368528.1">
        <property type="nucleotide sequence ID" value="NM_001381303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARP5"/>
    <dbReference type="SMR" id="A0A0K3ARP5"/>
    <dbReference type="GeneID" id="173401"/>
    <dbReference type="AGR" id="WB:WBGene00001340"/>
    <dbReference type="CTD" id="173401"/>
    <dbReference type="WormBase" id="T01D1.2s">
        <property type="protein sequence ID" value="CE50607"/>
        <property type="gene ID" value="WBGene00001340"/>
        <property type="gene designation" value="etr-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00001340">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARP5">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12362">
        <property type="entry name" value="RRM3_CELF1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000569">
        <property type="entry name" value="ELAV-Type RNA binding-protein family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="271"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CTQ86522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="T01D1.2s"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3ARP5"/>
        </source>
    </evidence>
    <sequence length="356" mass="37140" checksum="F88445AE65F5526D" modified="2015-11-11" version="1">MITGSGAGSPKGGAASLLQNLNPALLQQLGGGQNYQAVASLLSLINGQQGQQQQHQQQQNVLGILGTGNPLLGNPAMAAQNQFDAITMAQIAHQQQMLALQGFAVQQGAPSQQQQGLFLAHQYSTNYSTGSPDSASNATDSSSDDNNVMNNRLTPTSKMAQYGYGPLIPRHPAQLYLQQRFPATAAAYVPGLAGGMAGAKTTSPVAASLANHQQIALTPFAGGAAALDHFQAMQQYALLANLQATGGVGVQATTSAAQMVGNGDVKGPDGANLFIYHLPQDFGDSDLINTFAPFGGILSAKVFIDKVTNLSKCFGFVSYENAQSATNAISAMNGFQIGSKRLKVQLKVDRGNPYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARS2</accession>
    <name>A0A0K3ARS2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RING-type E3 ubiquitin transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">ncl-1</name>
        <name evidence="12" type="ORF">CELE_ZK112.2</name>
        <name evidence="14" type="ORF">ZK112.2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299853.1">
        <property type="nucleotide sequence ID" value="NM_001312924.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARS2"/>
    <dbReference type="SMR" id="A0A0K3ARS2"/>
    <dbReference type="GeneID" id="176084"/>
    <dbReference type="AGR" id="WB:WBGene00003559"/>
    <dbReference type="CTD" id="176084"/>
    <dbReference type="WormBase" id="ZK112.2b">
        <property type="protein sequence ID" value="CE50327"/>
        <property type="gene ID" value="WBGene00003559"/>
        <property type="gene designation" value="ncl-1"/>
    </dbReference>
    <dbReference type="OMA" id="LHDCAHI"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003559">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARS2">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19813">
        <property type="entry name" value="Bbox1_BRAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19798">
        <property type="entry name" value="Bbox2_BRAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20482">
        <property type="entry name" value="CC_brat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14959">
        <property type="entry name" value="NHL_brat_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002782">
        <property type="entry name" value="B-box type zinc finger protein ncl-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000107">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="349"/>
            <end position="392"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0007829" key="15">
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            <dbReference type="PeptideAtlas" id="A0A0K3ARS2"/>
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    <sequence length="982" mass="106083" checksum="9DEC04A9A4E4ED35" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3ARS4</accession>
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            <fullName evidence="6">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
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        <name evidence="13 15" type="primary">egl-8</name>
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    <organism evidence="13 14">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">Bristol N2</strain>
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        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <name>Ca(2+)</name>
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        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
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    <dbReference type="SUPFAM" id="SSF51695">
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    <keyword evidence="8" id="KW-0106">Calcium</keyword>
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    <keyword evidence="3 6 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0807">Transducer</keyword>
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            <position position="328"/>
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        <source>
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    </evidence>
    <sequence length="1318" mass="149465" checksum="1D1C080E84008E73" modified="2015-11-11" version="1"> </sequence>
</entry>
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    <accession>A0A0K3ARS9</accession>
    <name>A0A0K3ARS9_CAEEL</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="10 12" type="primary">fbxo-11.2</name>
        <name evidence="12" type="ORF">BE0003N10.3</name>
        <name evidence="10" type="ORF">CELE_BE0003N10.3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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                <consortium name="The C. elegans sequencing consortium"/>
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                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Bristol N2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001381723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3ARS9"/>
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    <dbReference type="PeptideAtlas" id="A0A0K3ARS9"/>
    <dbReference type="GeneID" id="182047"/>
    <dbReference type="KEGG" id="cel:CELE_BE0003N10.3"/>
    <dbReference type="AGR" id="WB:WBGene00015268"/>
    <dbReference type="CTD" id="182047"/>
    <dbReference type="WormBase" id="BE0003N10.3b">
        <property type="protein sequence ID" value="CE50245"/>
        <property type="gene ID" value="WBGene00015268"/>
        <property type="gene designation" value="fbxo-11.2"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427974at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00015268">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3ARS9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
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        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
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        <property type="entry name" value="PbH1"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF22">
        <property type="entry name" value="UBR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="586"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="7">
        <location>
            <begin position="586"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CTQ86558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WormBase" id="BE0003N10.3b"/>
        </source>
    </evidence>
    <sequence length="657" mass="72198" checksum="6EA4DBD67A794F89" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS00</accession>
    <name>A0A0K3AS00_CAEEL</name>
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        <submittedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">phf-10</name>
        <name evidence="11" type="ORF">CELE_F33E11.6</name>
        <name evidence="13" type="ORF">F33E11.6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300097.1">
        <property type="nucleotide sequence ID" value="NM_001313168.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS00"/>
    <dbReference type="SMR" id="A0A0K3AS00"/>
    <dbReference type="GeneID" id="3565141"/>
    <dbReference type="AGR" id="WB:WBGene00018013"/>
    <dbReference type="CTD" id="3565141"/>
    <dbReference type="WormBase" id="F33E11.6c">
        <property type="protein sequence ID" value="CE28295"/>
        <property type="gene ID" value="WBGene00018013"/>
        <property type="gene designation" value="phf-10"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018013">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS00">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001593">
        <property type="entry name" value="PHd Finger family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF4">
        <property type="entry name" value="PHD FINGER PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CTQ86796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WormBase" id="F33E11.6c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AS00"/>
        </source>
    </evidence>
    <sequence length="103" mass="11727" checksum="77F10D78BC6C4252" modified="2015-11-11" version="1">MICCATCKIAYHPQCIEMPERMAALVKTYEWSCVDCRLCSICNKPEKEDEIVFCDRCDRGFHTYCVGLKKLPQGTWICDTYCAIENMKFNRRASAAAVGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS01</accession>
    <name>A0A0K3AS01_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B box-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ncl-1</name>
        <name evidence="6" type="ORF">CELE_ZK112.2</name>
        <name evidence="8" type="ORF">ZK112.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299928.1">
        <property type="nucleotide sequence ID" value="NM_001312999.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS01"/>
    <dbReference type="SMR" id="A0A0K3AS01"/>
    <dbReference type="PeptideAtlas" id="A0A0K3AS01"/>
    <dbReference type="GeneID" id="176084"/>
    <dbReference type="AGR" id="WB:WBGene00003559"/>
    <dbReference type="CTD" id="176084"/>
    <dbReference type="WormBase" id="ZK112.2h">
        <property type="protein sequence ID" value="CE50238"/>
        <property type="gene ID" value="WBGene00003559"/>
        <property type="gene designation" value="ncl-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003559">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS01">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19813">
        <property type="entry name" value="Bbox1_BRAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19798">
        <property type="entry name" value="Bbox2_BRAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20482">
        <property type="entry name" value="CC_brat-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="B-box type zinc finger protein ncl-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000107">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
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        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
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        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF41">
        <property type="entry name" value="BRAIN TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="4"/>
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    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="3">
        <location>
            <begin position="576"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="3">
        <location>
            <begin position="623"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="3">
        <location>
            <begin position="669"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="3">
        <location>
            <begin position="711"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="3">
        <location>
            <begin position="754"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CTQ86628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WormBase" id="ZK112.2h"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AS01"/>
        </source>
    </evidence>
    <sequence length="854" mass="92324" checksum="18C7C66827375CDA" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS04</accession>
    <name>A0A0K3AS04_CAEEL</name>
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        <submittedName>
            <fullName evidence="3">Drought induced 19 protein type zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3 5" type="primary">kcmf-1</name>
        <name evidence="3" type="ORF">CELE_ZK652.6</name>
        <name evidence="5" type="ORF">ZK652.6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284603">
        <property type="protein sequence ID" value="CTQ86633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299933.1">
        <property type="nucleotide sequence ID" value="NM_001313004.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS04"/>
    <dbReference type="GeneID" id="176095"/>
    <dbReference type="AGR" id="WB:WBGene00022785"/>
    <dbReference type="CTD" id="176095"/>
    <dbReference type="WormBase" id="ZK652.6c">
        <property type="protein sequence ID" value="CE50416"/>
        <property type="gene ID" value="WBGene00022785"/>
        <property type="gene designation" value="kcmf-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7873042at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00022785">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS04">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CTQ86633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WormBase" id="ZK652.6c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AS04"/>
        </source>
    </evidence>
    <sequence length="488" mass="54614" checksum="AF93E665F01F31C3" modified="2015-11-11" version="1">MQLILSSVDFDLVYQGDPTRHYDERKIVSFTCPYCNITGLTERQFGTHVLSQHPEAPGYSVICPLCIGNTEMEHIQSKETENLSVHWTEIHLHTMENLFRSTEPITTRPVQRRPMLARRGNRAGVSRTAAQGRPLQDEIEMMTVPLLPGIRSSQRLMTSTGDRPTVVVESAVTHQDPNVQQVIRPLATIPIYPPTSDESGDETPQPAADSADESEDDNDIQELDDMQPIVEDEALKKDEFWKTLKTRISEEDVDLILETMKSTAKVKEDIDDKMPVWTQRPLKRLANAAQVTTTSDSEGDPGWLPLSFETTPIRSTGCGGYWSDKRFLRPRKMQREQSVASSNAEIMEKAEIALALIRASCLHEPVFTDPTKPDIALKEALQHLRLGEKPAKMMEYQAAEELVNMPERDPITTGEMEVEIPDFTARGYGQIVDGNIPLGVVPEADEAITNSEDEEIVGGETSGDDEDEQEDDENDSQDSSVPEEINID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS05</accession>
    <name>A0A0K3AS05_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF7622 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CELE_F36H9.2</name>
        <name evidence="2 4" type="ORF">F36H9.2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300102.1">
        <property type="nucleotide sequence ID" value="NM_001313173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS05"/>
    <dbReference type="SMR" id="A0A0K3AS05"/>
    <dbReference type="GeneID" id="185389"/>
    <dbReference type="KEGG" id="cel:CELE_F36H9.2"/>
    <dbReference type="AGR" id="WB:WBGene00018111"/>
    <dbReference type="CTD" id="185389"/>
    <dbReference type="WormBase" id="F36H9.2b">
        <property type="protein sequence ID" value="CE50960"/>
        <property type="gene ID" value="WBGene00018111"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5774917at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018111">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS05">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056039">
        <property type="entry name" value="DUF7622"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37433:SF19">
        <property type="entry name" value="ACTIVIN_RECP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37433">
        <property type="entry name" value="PROTEIN CBG25136-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24602">
        <property type="entry name" value="DUF7622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7622" evidence="1">
        <location>
            <begin position="146"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CTQ86801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F36H9.2b"/>
        </source>
    </evidence>
    <sequence length="235" mass="26281" checksum="211E4B395B25ED55" modified="2015-11-11" version="1">MTSWVSINGQITAQDCLTTRTDLSDRQCQTNRKGLVSCVCSTDMCNVDTFSIPTDIVLTAPPTIKCYNKFVDDDNFCFGQFCRYSRQLVPNDFGDVQISSFFPERGCSDLEYNHDLASMNVCYTNDEMIVCQCNTEFCNKDQPFDVPMGNLLCYYNSNGKPGNIPGMKYCRGHLCYVHTNYDIISRGCINVSDGGPEELKKKGGYLLYRFCDEDLCNGEITADPVVNVEGSGNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS08</accession>
    <name>A0A0K3AS08_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">clec-199</name>
        <name evidence="9" type="ORF">C30H6.1</name>
        <name evidence="7" type="ORF">CELE_C30H6.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CTQ86639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299938.1">
        <property type="nucleotide sequence ID" value="NM_001313009.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS08"/>
    <dbReference type="SMR" id="A0A0K3AS08"/>
    <dbReference type="GeneID" id="183064"/>
    <dbReference type="AGR" id="WB:WBGene00007820"/>
    <dbReference type="CTD" id="183064"/>
    <dbReference type="WormBase" id="C30H6.1g">
        <property type="protein sequence ID" value="CE50545"/>
        <property type="gene ID" value="WBGene00007820"/>
        <property type="gene designation" value="clec-199"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863877at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007820">
        <property type="expression patterns" value="Expressed in larva and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS08">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
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        <property type="entry name" value="C-type_Lectin_Domain_Fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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        <location>
            <begin position="21"/>
            <end position="656"/>
        </location>
    </feature>
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        <location>
            <begin position="108"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CTQ86639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C30H6.1g"/>
        </source>
    </evidence>
    <sequence length="656" mass="70671" checksum="18AAB4BE2B12C8E2" modified="2015-11-11" version="1"> </sequence>
</entry>
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    <accession>A0A0K3AS09</accession>
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        <name evidence="5 7" type="primary">nhr-190</name>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
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    <dbReference type="WormBase" id="F48G7.11b">
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        <property type="gene ID" value="WBGene00018622"/>
        <property type="gene designation" value="nhr-190"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841316at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018622">
        <property type="expression patterns" value="Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051152">
        <property type="entry name" value="C.elegans_Orphan_NR"/>
    </dbReference>
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        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45680:SF9">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CTQ86806.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F48G7.11b"/>
        </source>
    </evidence>
    <sequence length="366" mass="42602" checksum="4DC8DF2A056901A2" modified="2015-11-11" version="1">MRSAKSQDMVCERESCSLKDRIQCCKICRLKMCYDAGMDPNKFQTGRDLISSSSRSSNLSSVGSPQSLANFLGRPELILFCSPDRASSSKMIVDVSYLFEEMMKVYETPSCLPSPCQFENSLERMTFEMEDLNSKREIPNLQFQTSFDKNSFTRFWENSFLKTAQWFSTFAEFRELDTKIKTDILKSAGGLWIRLERMSETSVQRRKQNFGTNVMMCGEGKCVNVNEFDMDLSFCTHHSMDQLKPFLLAGISSWDAIVDALNLLIPTNVELNYMFIQLCLKPMLRKVEGHDLEIIEKILQVQADNLHNYYMKTLRTTHYSDRLTKMMRIIQLLEAYIRELKEKAHIAKVFDVFSIEFSHPEMFEYF</sequence>
</entry>
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        <submittedName>
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    <gene>
        <name evidence="7 9" type="primary">clec-199</name>
        <name evidence="9" type="ORF">C30H6.1</name>
        <name evidence="7" type="ORF">CELE_C30H6.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001313014.3"/>
    </dbReference>
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    <dbReference type="AGR" id="WB:WBGene00007820"/>
    <dbReference type="CTD" id="183064"/>
    <dbReference type="WormBase" id="C30H6.1l">
        <property type="protein sequence ID" value="CE50608"/>
        <property type="gene ID" value="WBGene00007820"/>
        <property type="gene designation" value="clec-199"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863877at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00007820">
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    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS12">
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    </dbReference>
    <dbReference type="GO" id="GO:0030246">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052309">
        <property type="entry name" value="C-type_Lectin_Domain_Fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490:SF6">
        <property type="entry name" value="ASIALOGLYCOPROTEIN RECEPTOR 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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        <location>
            <begin position="21"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="108"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CTQ86644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C30H6.1l"/>
        </source>
    </evidence>
    <sequence length="646" mass="69634" checksum="D1CC80F87E2086C0" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS13</accession>
    <name>A0A0K3AS13_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpentine Receptor, class T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">srt-17</name>
        <name evidence="2" type="ORF">CELE_F48G7.6</name>
        <name evidence="4" type="ORF">F48G7.6</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001300112.1">
        <property type="nucleotide sequence ID" value="NM_001313183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS13"/>
    <dbReference type="SMR" id="A0A0K3AS13"/>
    <dbReference type="GeneID" id="185994"/>
    <dbReference type="AGR" id="WB:WBGene00018617"/>
    <dbReference type="CTD" id="185994"/>
    <dbReference type="WormBase" id="F48G7.6d">
        <property type="protein sequence ID" value="CE50772"/>
        <property type="gene ID" value="WBGene00018617"/>
        <property type="gene designation" value="srt-17"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852380at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS13">
        <property type="expression patterns" value="differential"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
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            <begin position="35"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="170"/>
            <end position="191"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CTQ86811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WormBase" id="F48G7.6d"/>
        </source>
    </evidence>
    <sequence length="251" mass="28065" checksum="7C976A8C1007570E" modified="2015-11-11" version="1">MIFLGICDICSTFVHSITTGIFGIMGVVYCDFPLVIFILGSLGLGSWMGCCVSSIVLAVIRAGDVDSNRWIMRIFDGLKIYIVLGICLAYFLITIFLVKPVVFNENYSSWFTDPGLGHDPALYKNSLIAFNNFAVAICTIVFYGYISYVYLKKSKSGNSSTKLTKSQLSILLQTFFFCFFHAVTSLIYVYMDIFQVYDMLIFIAHFGWQCSSGAVCVVYLTLNNSIRQTVKKLFCTPPVSTVPSNMFTVVI</sequence>
</entry>
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        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
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            <taxon>Metazoa</taxon>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">Bristol N2</strain>
        </source>
    </reference>
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        <property type="gene designation" value="clec-199"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
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    </dbReference>
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        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052309">
        <property type="entry name" value="C-type_Lectin_Domain_Fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490:SF6">
        <property type="entry name" value="ASIALOGLYCOPROTEIN RECEPTOR 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="619"/>
        </location>
    </feature>
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        <location>
            <begin position="108"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="489"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CTQ86649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WormBase" id="C30H6.1q"/>
        </source>
    </evidence>
    <sequence length="619" mass="66920" checksum="FB58014C16A062B8" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS42</accession>
    <name>A0A0K3AS42_CAEEL</name>
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        <submittedName>
            <fullName evidence="9">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="9 10">
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="9851916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CTQ86689.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K3AS42"/>
    <dbReference type="SMR" id="A0A0K3AS42"/>
    <dbReference type="GeneID" id="177327"/>
    <dbReference type="AGR" id="WB:WBGene00021152"/>
    <dbReference type="CTD" id="177327"/>
    <dbReference type="WormBase" id="Y4C6A.2g">
        <property type="protein sequence ID" value="CE50445"/>
        <property type="gene ID" value="WBGene00021152"/>
        <property type="gene designation" value="mgl-3"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
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            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
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            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CTQ86689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="Y4C6A.2g"/>
        </source>
    </evidence>
    <sequence length="400" mass="44651" checksum="14AEE074877BA2EA" modified="2015-11-11" version="1">MASGRELCYCMMSGIGMCYTLTFFLVSQPTVITCSMTRILMGLSMSAIYAAIITKTNRLARVFKPDSAQRPRFITPKAQVGICMGIVSVQLIGTFVWILFDPPGTMIVFPTRTEAVLTCKATTSHLLISLLYNILLIVACTVYAFKTRKIPENFNETRHIGFTMYSTCILWLAFGPIYFATQSDFRIQITSLCMCISLSGTVALICFFAPKVYIVLFQPYKNVRTRQSAVGRLVNQQMRFMSQLTYNPDGCNSYQPMSSNQSYKPSISAEESSHTSNAQVQQPTRAIPPHVIEQLAASLPISDKNDLVKKLSLQDKFFNNNNNNENSEEIRRRRPSSVHTVGAVTNGSSVAHIPPRSYTDEPKSSMIRQDTAKSRTSLAESHQVDLILEEIAADTNSTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K3AS47</accession>
    <name>A0A0K3AS47_CAEEL</name>
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        <submittedName>
            <fullName evidence="5">Pry-1 Interacting and CABIN1 Domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">picd-1</name>
        <name evidence="5" type="ORF">CELE_F56E10.1</name>
        <name evidence="7" type="ORF">F56E10.1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CTQ86694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001299995.1">
        <property type="nucleotide sequence ID" value="NM_001313066.2"/>
    </dbReference>
    <dbReference type="GeneID" id="186391"/>
    <dbReference type="KEGG" id="cel:CELE_F56E10.1"/>
    <dbReference type="AGR" id="WB:WBGene00018975"/>
    <dbReference type="CTD" id="186391"/>
    <dbReference type="WormBase" id="F56E10.1a">
        <property type="protein sequence ID" value="CE50598"/>
        <property type="gene ID" value="WBGene00018975"/>
        <property type="gene designation" value="picd-1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S3K2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00018975">
        <property type="expression patterns" value="Expressed in germ line (C elegans) and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A0K3AS47">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1476"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1558"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1623"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1673"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1924"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1802"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1476"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1629"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1722"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1944"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1977"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2001"/>
            <end position="2021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CTQ86694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WormBase" id="F56E10.1a"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PeptideAtlas" id="A0A0K3AS47"/>
        </source>
    </evidence>
    <sequence length="2052" mass="232892" checksum="69A43AAE7D14C17F" modified="2015-11-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MDC6</accession>
    <name>A0A131MDC6_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="8">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">pygl-1</name>
        <name evidence="9" type="ORF">CELE_T22F3.3</name>
        <name evidence="11" type="ORF">T22F3.3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="8"/>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001309657.1">
        <property type="nucleotide sequence ID" value="NM_001322539.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MDC6"/>
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    <dbReference type="KEGG" id="cel:CELE_T22F3.3"/>
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    <dbReference type="CTD" id="178777"/>
    <dbReference type="WormBase" id="T22F3.3d">
        <property type="protein sequence ID" value="CE51362"/>
        <property type="gene ID" value="WBGene00020696"/>
        <property type="gene designation" value="pygl-1"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00020696">
        <property type="expression patterns" value="Expressed in adult organism and 4 other cell types or tissues"/>
    </dbReference>
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        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000197">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CZR14582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="T22F3.3d"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="A0A131MDC6"/>
        </source>
    </evidence>
    <sequence length="247" mass="27706" checksum="C3489CADD4C83083" modified="2016-05-11" version="1">MVKRTVLYGGKAAPGYHMAKQIIRLITAVAEQVNNDAIVGDRLKVIFLENYRVSMAEKIIPASDLSEQISTAGTEASGTGNMKFMLNGALTIGTLDGANVEMAEEMGDENIFIFGMNVEEVEALTKRGYSSQEFIDKSPMLKQIIEQIEGGMFTPEDPDQLKDLSNMLRYHDRFMVCADFDAFIEAQDKVSATFRDQEKWSRMALYNIASTGKFSTDRTITEYAREIWGIDQFESSLPAPYENEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A131MDD8</accession>
    <name>A0A131MDD8_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear Hormone Receptor family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">nhr-93</name>
        <name evidence="12" type="ORF">CELE_T24A6.9</name>
        <name evidence="14" type="ORF">T24A6.9</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284605">
        <property type="protein sequence ID" value="CZR14592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001380193.1">
        <property type="nucleotide sequence ID" value="NM_001392494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A131MDD8"/>
    <dbReference type="SMR" id="A0A131MDD8"/>
    <dbReference type="GeneID" id="13212318"/>
    <dbReference type="AGR" id="WB:WBGene00003683"/>
    <dbReference type="CTD" id="13212318"/>
    <dbReference type="WormBase" id="T24A6.9c">
        <property type="protein sequence ID" value="CE51392"/>
        <property type="gene ID" value="WBGene00003683"/>
        <property type="gene designation" value="nhr-93"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984314at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00003683">
        <property type="expression patterns" value="Expressed in embryo and 2 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A131MDD8">
        <property type="expression patterns" value="baseline"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000070">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="PROSITE" id="PS51843"/>
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            <dbReference type="EMBL" id="CZR14592.1"/>
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            <dbReference type="Proteomes" id="UP000001940"/>
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    </evidence>
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            <dbReference type="WormBase" id="T24A6.9c"/>
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        <name type="scientific">Caenorhabditis elegans</name>
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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            <dbReference type="PubMed" id="9851916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">Bristol N2</strain>
        </source>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="87"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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</entry>
<entry dataset="TrEMBL" created="2017-12-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
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        <subcellularLocation>
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    </comment>
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        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
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        <property type="gene designation" value="unc-89"/>
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<entry dataset="TrEMBL" created="2017-12-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
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    <accession>A0A5E4LWY0</accession>
    <name>A0A5E4LWY0_CAEEL</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <strain evidence="4 5">Bristol N2</strain>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2663"/>
            <end position="2683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2700"/>
            <end position="2715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2751"/>
            <end position="2764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2768"/>
            <end position="2785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2786"/>
            <end position="2795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2810"/>
            <end position="2825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2826"/>
            <end position="2850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2853"/>
            <end position="2869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2875"/>
            <end position="2890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2910"/>
            <end position="2936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2937"/>
            <end position="2949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="3034"/>
            <end position="3043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3059"/>
            <end position="3077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA0059127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="T06D8.1f"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PeptideAtlas" id="A0A5S9MPU7"/>
        </source>
    </evidence>
    <sequence length="3443" mass="354331" checksum="887C5612511698DE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5S9MPX1</accession>
    <name>A0A5S9MPX1_CAEEL</name>
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        <submittedName>
            <fullName evidence="9">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="ORF">C05C10.2</name>
        <name evidence="9" type="ORF">CELE_C05C10.2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Bristol N2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284602">
        <property type="protein sequence ID" value="CAA0059137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001364520.1">
        <property type="nucleotide sequence ID" value="NM_001377847.2"/>
    </dbReference>
    <dbReference type="SMR" id="A0A5S9MPX1"/>
    <dbReference type="GeneID" id="174546"/>
    <dbReference type="AGR" id="WB:WBGene00007329"/>
    <dbReference type="CTD" id="174546"/>
    <dbReference type="WormBase" id="C05C10.2c">
        <property type="protein sequence ID" value="CE53842"/>
        <property type="gene ID" value="WBGene00007329"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5856787at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="A0A5S9MPX1">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002131">
        <property type="entry name" value="Uncharacterized ATP-dependent helicase C05C10.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF16">
        <property type="entry name" value="HELICASE WITH ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="7">
        <location>
            <begin position="850"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="8">
        <location>
            <begin position="1112"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1343"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1343"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1364"/>
            <end position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAA0059137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WormBase" id="C05C10.2c"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PeptideAtlas" id="A0A5S9MPX1"/>
        </source>
    </evidence>
    <sequence length="1404" mass="159104" checksum="0731D1B2174FB6FE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6V7QZA2</accession>
    <name>A0A6V7QZA2_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear hormone receptor HR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">daf-12</name>
        <name evidence="14" type="ORF">CELE_F11A1.3</name>
        <name evidence="16" type="ORF">F11A1.3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Bristol N2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX284606">
        <property type="protein sequence ID" value="CAD1857025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001407484.1">
        <property type="nucleotide sequence ID" value="NM_001420577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6V7QZA2"/>
    <dbReference type="SMR" id="A0A6V7QZA2"/>
    <dbReference type="GeneID" id="181263"/>
    <dbReference type="AGR" id="WB:WBGene00000908"/>
    <dbReference type="CTD" id="181263"/>
    <dbReference type="WormBase" id="F11A1.3e">
        <property type="protein sequence ID" value="CE54230"/>
        <property type="gene ID" value="WBGene00000908"/>
        <property type="gene designation" value="daf-12"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6352325at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06966">
        <property type="entry name" value="NR_DBD_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06929">
        <property type="entry name" value="NR_LBD_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000042">
        <property type="entry name" value="Nuclear hormone receptor HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF494">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER DAF-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="56"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="441"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="207"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAD1857025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WormBase" id="F11A1.3e"/>
        </source>
    </evidence>
    <sequence length="678" mass="75716" checksum="6D91F6A7F30AF9AF" modified="2020-12-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-09-01" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C6ELT9</accession>
    <name>C6ELT9_CAEEL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">oac-57</name>
        <name evidence="4" type="ORF">CELE_K09E10.1</name>
        <name evidence="6" type="ORF">K09E10.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Bristol N2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CAZ65510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255638.1">
        <property type="nucleotide sequence ID" value="NM_001268709.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C6ELT9"/>
    <dbReference type="GeneID" id="187224"/>
    <dbReference type="KEGG" id="cel:CELE_K09E10.1"/>
    <dbReference type="AGR" id="WB:WBGene00019579"/>
    <dbReference type="CTD" id="187224"/>
    <dbReference type="WormBase" id="K09E10.1b">
        <property type="protein sequence ID" value="CE43940"/>
        <property type="gene ID" value="WBGene00019579"/>
        <property type="gene designation" value="oac-57"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_12_1_1"/>
    <dbReference type="OrthoDB" id="5825384at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00019579">
        <property type="expression patterns" value="Expressed in larva and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="C6ELT9">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF118">
        <property type="entry name" value="ACYL_TRANSF_3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="9"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="3">
        <location>
            <begin position="348"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAZ65510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WormBase" id="K09E10.1b"/>
        </source>
    </evidence>
    <sequence length="532" mass="61578" checksum="4643FE6A0E9C8E7F" modified="2009-09-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-04-20" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>D3YT50</accession>
    <name>D3YT50_CAEEL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NAD-dependent protein deacetylase sir-2.1</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein sir-2.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Regulatory protein SIR2 homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">sir-2.1</name>
        <name evidence="16" type="ORF">CELE_R11A8.4</name>
        <name evidence="18" type="ORF">R11A8.4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caenorhabditis elegans</name>
        <dbReference type="NCBI Taxonomy" id="6239"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Rhabditoidea</taxon>
            <taxon>Rhabditidae</taxon>
            <taxon>Peloderinae</taxon>
            <taxon>Caenorhabditis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="1998" name="Science" volume="282" first="2012" last="2018">
            <title>Genome sequence of the nematode C. elegans: a platform for investigating biology.</title>
            <authorList>
                <consortium name="The C. elegans sequencing consortium"/>
                <person name="Sulson J.E."/>
                <person name="Waterston R."/>
            </authorList>
            <dbReference type="PubMed" id="9851916"/>
            <dbReference type="DOI" id="10.1126/science.282.5396.2012"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Bristol N2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-4480509">
            <id>D3YT50</id>
        </interactant>
        <interactant intactId="EBI-4480523">
            <id>G5EC23</id>
            <label>hcf-1</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="BX284604">
        <property type="protein sequence ID" value="CBK19468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001255485.1">
        <property type="nucleotide sequence ID" value="NM_001268556.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D3YT50"/>
    <dbReference type="SMR" id="D3YT50"/>
    <dbReference type="IntAct" id="D3YT50">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="D3YT50"/>
    <dbReference type="GeneID" id="177924"/>
    <dbReference type="AGR" id="WB:WBGene00004800"/>
    <dbReference type="CTD" id="177924"/>
    <dbReference type="WormBase" id="R11A8.4b">
        <property type="protein sequence ID" value="CE44629"/>
        <property type="gene ID" value="WBGene00004800"/>
        <property type="gene designation" value="sir-2.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016587_1_0_1"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000001940">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Bgee" id="WBGene00004800">
        <property type="expression patterns" value="Expressed in embryo and 4 other cell types or tissues"/>
    </dbReference>
    <dbReference type="ExpressionAtlas" id="D3YT50">
        <property type="expression patterns" value="baseline and differential"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein lysine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040024">
        <property type="term" value="P:dauer larval development"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="WormBase"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1600.10:FF:000013">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1267">Proteomics identification</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="15">
        <location>
            <begin position="98"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBK19468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WormBase" id="R11A8.4b"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PeptideAtlas" id="D3YT50"/>
        </source>
    </evidence>
    <sequence length="577" mass